text:
Q: HQL return java.lang.NoSuchMethodError I am trying to set parameter in HQL this way:
 Query query = session.createQuery("from Device d " +
                    "left join fetch d.tradeInOldDevice " +
                    "left join fetch d.tradeInNewDevice " +
                    "left join fetch d.warranty "  +
                    "where d.owningCompany.customerRefId =:customerId ");

              query.setString("customerId", "someHardCodeCustomerId");

            Set<Device> customerDevices= (Set<Device>) query.list();

I am gettig that error:
ספט 24, 2013
2:36:02 PM org.apache.catalina.core.StandardWrapperValve invoke
SEVERE: Servlet.service() for servlet [ServicesServlet] in context with path [] threw exception [Servlet execution threw an exception] with root cause
java.lang.NoSuchMethodError: antlr.collections.AST.getLine()I
    at org.hibernate.hql.ast.HqlSqlWalker.generateNamedParameter(HqlSqlWalker.java:945)

Hibernate dependcies:
 <dependency>
            <groupId>org.hibernate</groupId>
            <artifactId>hibernate-validator</artifactId>
            <version>5.0.1.Final</version>
        </dependency>

<!-- Hibernate -->
        <dependency>
            <groupId>org.hibernate</groupId>
            <artifactId>hibernate-c3p0</artifactId>
            <version>3.6.10.Final</version>
        </dependency>

I am running hibernate on tomcat inside Spring container.
I checked maven dependencies in My project I have Maven: antlr:antlr:2.7.2.
What could be wrong here?
thanks.

A: Library conflict. I think you have another version of antlrXXX.jar loaded in web-inf/lib. This is loaded before the one on which hibernate depends on.
Pleasse complete the question with the used hibernate version so that I can reply putting the correct dependency for completness.
Update:
After the comments the conflicting version is 2.7.2.
Check who is importing 2.7.2 using mvn dependency:tree and exclude that transitive dependency in the pom.

A: This is because the antlr-2.7.2.jar struts2 and Hibernate antlr-2.7.7.jar conflict, as long as the antlr-2.7.2.jar struts2 file can either remove this problem does not occur. You can try.
If such an error is reported: Then you go to your tomcat application under this WEB WEB-INF Under the lib antlr-2.7.2.jar will be deleted. .

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Nobody Wants The Flu! Here Is How You Can Help Prevent It!
The time is here. Everyone is getting sick. You don't have time to get sick. Who does? Here are some ways you can keep it away.
The obvious one that helps is getting the flu shot or mist. It does not guarantee the flu stays away because there are way too many strands out there to know which one will be prevalent but if you do get it....the flu will not last as long.
Wash your hands! Oh and I mean a lot. Flu germs are spread easily by the germs on your hands. So wash them to keep from spreading germs. Oh and just as important is to avoid touching your face. Germs tend to transfer from your hands to your mouth or nose. So avoid touching at all cost.
It helps you out a lot if you get plenty of sleep and eat healthy. The more you can boost your immune system the better your chance to avoid getting sick. Your diet and sleep habits are really important to your well being. Vitamins are important too so up your intake of Vitamin C. Vitamin C helps the body keep you strong and healthy.
You also need to get outside as much as you can. We tend to share germs and sickness because we are cooped up inside.So get out and breath the fresh (albeit cold) air.
Here is to a healthy end of 2018 and continue it into 2019!


text:
THE SOURCE MAGAZINE APRIL 1996 ISSUE-79 ICE T BUSTA RHYMES LIL KIM FOXY BROWN
The SOURCE Magazine #79 April 1996 Ice-T Busta Rhymes Lil Kim Foxy Brown RARE
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Details about The SOURCE Magazine #79 April 1996 Ice-T Busta Rhymes Lil Kim Foxy Brown RARE
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On Friday 6th May Nicola Winters from Green Sod visited the school. Nicola gave a really interactive presentation to 1st year science and 5th year Agricultural Science classes. Students learned more about the area of biodiversity, it's importance, how we can help with biodiversity and sustainability as consumers and how we can take a more proactive approach to nature and the world around us. This linked in with our Green Schools Biodiversity theme which we are currently focusing on and our development education module in school.
Out in our polytunnel students learned how to make their own compostable potting plants using newspaper and got to plant some lettuce and parsley in them which will be used in Home Economics cookery classes.


The purpose of this essay was to investigate the problems of secondary schools administration with reference to supervision of instruction and discipline as affected both the effectiveness and efficiency of teaching and learning processes in Remo-North Local Government Area of Ogun State.
For the purpose of the study, questionnaire was designed and administered for the teachers (respondents) drawn from the sampled schools.
i. Principals have little or no time to do effective supervision in schools.
iii. Poor quality of teaching and learning is a bye-product of ineffective supervision.
iv. Indisciplinary problems abound in schools.
Above all, suggestions were made on the ways of solving the identified problems of supervision of instruction and discipline in schools, so that the school system is improved upon for good quality.
The pride of every educational system depends mostly on the good quality of its products (Erinle, 2003). The quality however depends on the standard of administration (supervision and discipline) which both the teachers and students enjoy. Therefore, if this statement is acceptable to us in education enterprise, it could be said that, the present standard of our educational system and the products which it produces could be said to be the bye-products of its system.
"primary schools have virtually decayed secondary schools are congested, both Colleges of Education and Polytechnics exist under their old shadows, while Universities and research centres are the worst".
Hence the above contention actually describes the prevailing conditions and situations in our educational institutions.
However, many factors have been identified as being responsible for the above circumstances in our schools today in which both supervision of instructions and effective discipline are taking the lead other factors are either poor or inadequate funding, absence of better learning conditions, inadequate supply of both qualified and experienced teachers as well as over population of students in classes.
Therefore, if both supervision of instruction and discipline are regarded as an important integral part of school administration, which the secondary school administrator (i.e. the principal) should undertake, then, the supervision of instruction and discipline towards raising both the standard /quality of learning and upgrade the tone of the school should however be greatly improved upon by giving adequate attention.
It is necessary to state it clearly from the onset that no matter the level and professional capability of a school administrator is, if such school could not produce useful and responsible citizens to the society, such school is bound to face negative criticisms and attacks from all angles. It then follows that, before any school could be said to receive the blessings and support of the society, the quality of what the students receive in such schools should be good-enough to prove its worth.
Finally, it is therefore to belief of this researcher to make sure that, problems of supervision of instructions and effective enforcement of better discipline as it affects secondary schools in Remo North Local Government will be the main focus of her research works.
Specifically, this work is intended mainly to investigate the problems of supervision of instructions and effective enforcement of discipline in secondary schools in Remo North Local Government Area of Ogun State which arises as a result of the inability of the agencies saddled with the responsibility of administering the schools.
Further to this, the type of supervision, problems which would be looked into will include the inability of the principals of the secondary schools to supervise instructions effectively and the factors militating against their functions. Also, the role of the individual teacher in the process of supervision of instructions is generally low and inadequate, thus not – encouraging and why this is so?
However, since it is only in the atmosphere of peace and orderliness that effective supervision of instructions could take place, the study will therefore include other disciplinary problems of the schools which include students disregard to the school authorities as well as students disregard to the school rules and regulations.
The main purpose of this research work is to critically examine the problems of secondary school administration in Remo North Local Government of Ogun State specifically; the problems shall include adequate supervision of instruction and effective enforcement of good discipline in the entire school system.
Apart from the above, the extent to which the school administrators (i.e. the principals and staff) conceive and perceive these administrative problems will be fully examined. Also, the efforts of both the teachers and principals in solving the highlighted administrative problems will be reforce be the major focus of the study.
i. That, the more the problem of supervision of instruction exist in secondary schools, the less the achievement of the school goals will be.
ii. That, the more the problem of indiscipline in secondary schools persists, the more difficult, it is to produce responsible citizens towards realizing the aspiration of the schools.
iii. That, the more, the problem of indiscipline persists in our secondary schools, the less the tone of the school will be.
The main aim of this research work is to investigate into the various factors militating against effective secondary schools administration in Remo-North Local Government Area of Ogun State with the sole aim of finding necessary solutions to the problems in attempt to improve the quality of service delivery.
(a) To find out factors responsible for ineffective supervision of instructions.
(b) To find out what actually contribute to the problems of effective discipline in secondary schools.
(c) To find out the contributions of both the teachers and non-teaching staff to the administrative problems in secondary schools.
(d) To find out solutions to such problems through recommendations or suggestions towards better service delivery in secondary schools.
i. There would be no significant differences between effective supervision and administration of the school.
ii. There would be no significant differences between adequate school discipline and administration of the school.
i. Does the principal have time to supervise his/her teachers regularly?
ii. Does the principal make use of his/her teachers during supervision of instruction processes?
iii. What is the attitude of the teachers towards effective supervision of instructions?
iv. Do the principal and teachers cooperate in all issues relating to the effective discipline in the schools?
v. What is the general effect of the absence of effective discipline on the process of supervision of instruction in the secondary schools investigated?
As the individual, the government, the general public and indeed, all the education practitioners and stakeholders are aware of the various difficulties militating against the effective development of education at all levels especially at the secondary school level.
Therefore, the area of the concentration of this researcher is to carefully investigate the various problems of secondary school administration in Remo North Local Government Area of Ogun State with the aim of finding necessary and required remedies to them for effective service delivery.
Also, the area of study is located in the Northern part of the present day Remo division of Ogun State. On the area's socio-economic characteristics, the people in the area of study share common languages, food, dressing, values, attitudes and traditions. They practice agriculture while some of its people also involve themselves in small scale business.
Secondary School: The second stage/level in any formal education which comes up after primary education and before tertiary education in the current Nigeria educational system. This educational level is run for six years.
Administration: To govern, to direct, to control, or to coordinate.
Supervision: Watching over something to see that, it is done well or to monitor programme or activity to ensure that it is carried out as expected.
Instruction: Teaching a course of study.
Discipline: Orderliness or doing the right thing at the right time without being force to it or an atmosphere of peace and order.


Clean, rounded lines define this easy to carry satchel. It comes with scratch-resistant Saffiano leather, a great, smart and stylish choice for everyday finished.
The Mophie Juice Pack Battery Case extends the battery life of your iPhone 5s/5 for hours with up to 80% more power so you can keep talking, surfing and sending. My Mophie Juice Pack Case has saved me more times than I can count!!!
The stretchy ties come in a variety of colors so you can choose which best complements the day's outfit.
If you follow the Dave Ramsey plan like I do, a cute cash envelopes system is a must. I had a friend make mine for me, but this one is another great option!
Our family would be lost without our essential oil products. We love Thieves spray! It freshens breath, helps with sore throats, and also serves as a handy dandy on-the-go sanitizer!
If you've ever had a wardrobe malfunction, you know how embarrassing it can be. This mini sewing kit will allow you to sew a button back on, use a safety pin to keep things together and you can even stitch up that seam that ripped in an inopportune place!
Hempz Lips Moisturizing Lip Balm is my go-to lip balm for dry lips. It's smooth and creamy and feels absolutely heavenly on dry chapped lips! I love that I can use it over or under my lipstick.
I hate it when my hands are dry! This Aveda Hand Relief creme keeps my skin feeling soft and supple! And I LOVE the way it smells!
This model fits easily in your pocket or purse. It also features glow-in-dark locking safety cap that makes it easier to find and use in the dark.
These toothwipes are perfect for when you're in a pinch and you can't brush your teeth. They're flouride free and can be used by kids or adults!
When I kicked off Project 36, I had no doubt in my mind that I would and could accomplish everything on my list. I knew some of the items on my list would be a stretch, but I needed a good challenge. I had no idea that our life was going to drastically change this year and that my time, my efforts, and most of my energy would be spent on the 2 new additions to our family. It seems like everything has fallen to the wayside since we added the twins to our family and now that life is moving along at a less chaotic pace (and also now that we're only 37 days away from my 37th birthday), I thought I'd check in to see how I'm doing with Project 36.
1. Make my bed 36 days in a row.
10. Do T-Tapp Basic Workout Plus 36 times.
As I looked through the list, I was shocked to see that I've only completed 4 of the 36 items. I think that if I really go after it for the next 37 days, I can accomplish 21 more of these goals. While I had hoped for a 36 out of 36 (A+), it looks like I'll end up with 25 out of 36 (69% D).
Taken 108 good pictures of people in my family plus taken 36 pictures of myself.
So here's to the next 37 days! I'm going to be a busy girl, but I'm looking forward to being able to say that I accomplished these things!
Last year, after lots of hard work and discipline, I looked like this.
This year, I look like this…and this is after losing 20 pounds.
As you can see, I weigh a ton more in this picture. While I'm tempted to hide this picture, I'm not going to. It is what it is.
For the record, after getting home from that weekend, I decided to get super strict about my eating and exercising. I've been gluten-free and sugar-free for 13 days and I've been exercising 4-5 days every week since I've been home! I'm thrilled to report that I've lost 11.2 pounds since being home….which puts me less than 5 pounds away from my first 36 pound goal.
I also found out over the weekend that my brother is getting married in 11 weeks so I really need to step up my game! 🙂 I'll definitely keep you posted. I'm hoping that I'll have amazing results over the next 11 weeks and that by the first weekend in January, I'll be able to post a picture of me in my wedding finery alongside my picture from October 4 and see a complete transformation.
In the meantime, I've decided that I WILL NOT let the way I feel about the way I look keep me from making an effort to look cute every single day.
So those are my goals for the next 11 weeks… What are yours?


P920 M50 (40 x 50 mm): Oval, 920 Series, Polarized Clip on sunglasses.
Height of each lens(Frame included)= 40 mm or 1.550 inches.
Max= 72 mm or 2.850 inches.
1) P925 M40x50 (40x50 mm): Oval Polarized Clip ons.
2) N920 L (40x50 mm): Oval Night Driving, Computer and Shooting Clip ons.
3) CM925 L (40x52 mm): Oval Clip ons, with Color Mirror lens.
Notify me of updates to P920 M50 (40x50 mm): Oval, Polarized Clip ons.


Making a joyful noise from down under is Rach Brennan & The Pines, a five-piece band from Geelong, Australia that is bringing a sunnier side to the singer-songwriter's table. The band has a distinctive close-knit vocal style; sparkling clean guitars, and a feel-good pop/rock beat. With song subjects dealing with friendship, innocence and the unabashed naivety of falling in and out of love. Rach Brennan & The Pines are releasing a new single called "I Wanna See You," The second single from Rach Brennan & The Pines debut album. Sporting a catchy melody and creative vocal harmonies and backgrounds, the track has a vintage vibe with smart musical development and song form. That's the short of it!
Rach Brennan and the Pines are a well-oiled five-piece group that offers smartly woven harmony's, timeless lyrics and a musicality to their sound that lingers long past the listen. All of the elements one looks for in a hit tune.
This group has a winning recipe for success. Accessible tunes that offer memorable melodies and catchy hooks to stick to your bones. With each listen clear subtleties reveal themselves, making for an enjoyable repeat play. Their feel good sound is infectious and one I hope that carries them far along their journey of success.


The World Water Week — 2017 kick-started on August 28 here with several senior political dignitaries attending the plenary session. The political leadership included Mayor of Stockholm, Karin Wanngard, the Swedish Minister of environment, Karolina Skog, the Dutch Minister of Infrastructure and the Environment, Melanie Schultz van Haegen and the Finance Minister of Ecuador, Carlos Torre.
The annual event is hosted by the Stockholm International Water Institute (SIWI) in the city of Stockholm and this year it is taking place continuously for the 27th time. World Water Week addresses the planet's water issues and related concerns of international development in concrete terms. The event had attracted 3000 participants from 130 countries last year.
Leaders and experts from the world's scientific, business, government and civil society will deliberate during the coming week the delicate matter of global water challenges. World Water Week is a yearly alert to the global citizens about the looming crisis of water that both the developed and the developing world are facing. Executive Director of SIWI, Torgny Holmgren, articulated the message of Water Week to the world: Respect and understand water.
Speaking in the plenary session, the Mayor of Stockholm, Karin Wanngard, described this year's theme, ''Water and Waste: Reduce and Reuse¨, as an important reminder of the fragility of water element.
The President of the United Nations General Assembly, Peter Thomson, said that the oceans of the world unite people of the world, and we should take care of them as they have always taken care of us. He added that among the Sustainable Development Goals (SDG) of United Nations, 17 goals have water in them.
Karolina Skog, Minister of Environment of Sweden, invited the audience of the plenary session to discuss the essence of water. She also pointed out the strong links water has with city-planning, industry, health and sustainable environment.
The SIWI World Water Week is not an oratorical competition on the theme of water. The event wants the world to become more water wise and draw attention to the sordid fact that more than 2 billion people in this world do not have access to clean water at this very moment.
During this entire week, the thematic scope of Water Week will address issues like the drivers, the water-waste cycle, health and biodiversity, water quality management and the industry and urban dimensions of water.
"As has also been amply demonstrated the cutting down of consumption, and of production for home consumption, of many other items besides food, and in all the developed countries, is rational and in our own interest. This is what the discussion of the 'quality of life' is all about. Our economic growth in a true sense, but it should be directed differently, and in a planned way, to serve our real interest in a better life."
Good to see people who can help make a difference once again deliberate upon an issue that affects the survival of the human kind. By now enough has been talked. Problems are well identified and solutions, too, known. Does the political leadership have the will power to confront industry's unquenchable thirst?


text:
Purpose of network sewage pumping stations
METALCHEM-WARSZAWA S.A. offers modern complete tank pumping stations for municipal and industrial sewage, rainwater, as well as for technological processes in sewage treatment plants and waste utilization and storage plants. Depending on the application and expected performance, we use one, two, three and multi-pump pumping stations. We can also divide them into municipal sewage pumping stations (with predictable and regular inflow), rainwater (large and irregular inflow) and process (controlled according to the client's special guidelines or with dosing systems).
Complete sewage pumping stations offered by Metalchem-Warszawa S.A .:
Complete sewage pumping station in the tank from PMB
Tank made of: KBZ (concrete), PMB (polymerconcrete), PEHD (high density polyethylene) i TWS (synthetic fibers reinforced with fiberglass),
Submersible pumps – with a range from 1.1kW to 22kW produced by METALCHEM-WARSZAWA S.A. or up to 50kW from other manufacturers,
Supply and control switchboard – produced by METALCHEM-WARSZAWA S.A..,
Medium level signaling unit – float set or hydrostatic probe (secured with two floats Suchobieg & Alarm),
Stop and return fittings – valves (ball, less often flap) and gate valves (wedge with rubber or knife),
Discharge pipelines int. tank – depending on the size and capacity of the pumps: Dn50, Dn65, Dn80, Dn100, Dn125, Dn150, Dn200, Dn250 or Dn300 made of stainless steel (304, 316 / 316L).
Support structures and ensuring safety
and ease of use – service platforms, top covers with manholes locked with a padlock or key, handrails, ladders to the bottom of the tank, ventilation chimneys, fittings supporting elements, flushing connectors, inflow deflectors, bringing knobs to ground level,
Equalizer connections ,
Assembly and delivery to the construction site – as agreed with the investor.
Free-standing sewage pumping stations
Free-standing pumping station
Service platforms – we use in all of our facilities over 3-3.3m high and above 1200mm in diameter. The tilting platforms used in pumping stations allow the user to operate the shut-off and return valves safely and, if necessary, go down the ladder to the bottom of the tank.
Pumps are pulled out after two widely spaced guides to the top , which facilitates their reinstallation even in the case of a completely flooded pumping station, and when lowering, the pump always settles properly on the coupling knee (without turning and special aiming of the catch ).
Pumping covers METALCHEM-WARSZAWA have an internal safety grille, enabling pumping ventilation at the same time protecting against falling in, directly after opening the hatch (loss of consciousness due to vapors from the tank) or by carrying out work around the tank cover.
Interior of sewage pumping station
Double gravitational ventilation ensures continuous circulation and air exchange. Ventilation chimneys (long and short) can be equipped with anti-odor filters with a BIOFILTR type insert or ACTIVE CARBON on customer's request.
Sealed cable entries in the switchgear eliminate the possibility of damage to the vapor control systems from the tank,
Support structures , pump chains and screw joints are made of stainless steel, thanks to which their durability in an aggressive sewage environment is many years,
Rinsing circuit – manual or automatic (MASP) for moving sediments and breaking the scum in the tank. This facilitates self-cleaning of the pumping station from accumulated sand, grease and all kinds of sludge.
Underroad sewage pumping stations
In the event that sewage pumping stations have to be built up along a communication route such as: street, maneuvering area or pavement, the tank cover is placed under the terrain and only the sewer manhole remains on a par with the ground surface. Such tanks have a reinforced structure to carry higher loads and better dampen vibrations caused e.g. by car traffic.
Pumping station built in the pavement
In underroad sewage pumping stations, access to pumps is difficult, so depending on the size of containers and pumps, we use one, two or more channel manholes with a diameter of min. 800 mm.
The METALCHEM-WARSZAWA pumping stations, thanks to their unique design, provide comfort to the user, the pumps are lowered along the guides pulled out under the manhole cover.
The manholes we use have a hinge and, optionally, a key or bolt lock, which prevents them from opening under the influence of vehicle traffic above them. The most commonly used hatches are round Ø800, square 800×800 and rectangular hatches 600×900. All hatches are of class D400.
Underroad pumping station
Shutter knobs are available from the level of the service platform as in free-standing pumping stations (see restrictions due to tank diameter and height). It is also possible to bring out the knob knobs so that they are accessible from ground level after removing the manhole or in separate street boxes next to the manhole.
The switchboard is placed at a safe distance from the tank, outside the vehicle exposure zone.
Slide knobs lead up
At the request of the customer in the switchboard and under the manhole it is possible to install a burglary sensor (facility opening).
With the appropriate height between the ground and the tank hidden underground, it is possible to build a portable crane foot in the street box, which greatly facilitates pulling out the pumps.


text:
Tokyo Mirage Sessions♯FE, connu sous le nom  au Japon et initialement nommé Shin Megami Tensei X Fire Emblem, est un jeu vidéo de rôle développé par Atlus et Intelligent Systems, mélangeant l'univers de Shin Megami Tensei et le système de jeu de Fire Emblem. Il est sorti sur Wii U en  au Japon et en  en Amérique du Nord et en Europe. Une version remasterisée du titre intitulée Tokyo Mirage Sessions♯FE Encore est sortie sur Nintendo Switch le  avec des sous-titres en français.

Univers

Histoire
L'histoire se déroule à Tokyo, au Japon. Le joueur suit les aventures d'un groupe d'adolescents rêvant de devenir des idoles de la chanson, du mannequinat et de la comédie. Tous font partie de l'agence Fortuna Entertainment, présidée par Maiko Shimazaki, une jeune femme d'affaires réputée. Elle forme également secrètement les jeunes Maîtres Mirage. En effet, les humains cohabitent avec les mirages venus d'un monde parallèle appelé Idolasphère. Ces créatures puissantes sont autant bienveillantes que destructrices..

Personnages
Le joueur est aux commandes d'un groupe d'adolescents, composé de sept membres. Chacun d'entre eux est en binôme avec un mirage provenant de l'univers de Fire Emblem. Le leader du groupe est Itsuki Aoi, que le joueur incarne tout au long du jeu. Il est soutenu par Chrom, le Lord héros de Fire Emblem: Awakening. Il est accompagné de Tsubasa Oribe, son amie d'enfance, et Touma Akagi, son meilleur ami, respectivement en duo avec Shiida, Chevalier Pégase, et Cain, Cavalier, tous deux issus de Fire Emblem: Shadow Dragon.

Tout au long de l'aventure, de nouveaux membres, tous issus de l'agence Fortuna Entertainment,  intègrent le groupe. Ainsi sont accueillies Kiria Kurono, une idole très populaire, et son mirage, Tharja, Mage Noir provenant de Fire Emblem: Awakening, mais aussi Eleonora Yumizuru, actrice internationale, en binôme avec l'Archer Virion de Fire Emblem: Awakening. De même, la jeune Mamori Minamoto, connue pour ses émissions de cuisine au micro-ondes, intègre le groupe aux côtés de Draug, Chevalier de Fire Emblem: Shadow Dragon. Enfin, après avoir été en rivalité avec Itsuki, Yashiro Tsurugi, un célèbre chanteur, rejoint l'équipe avec l'Épéiste Navarre, issu de Fire Emblem: Shadow Dragon.

D'autres personnages tiennent également un rôle dans l'agence Fortuna Entertainment, bien qu'ils ne combattent pas. Tiki, la jeune Manakete de Fire Emblem: Shadow Dragon, soutient les joueurs depuis un endroit nommé le Palais Fleuri en leur conférant des armes, des techniques et en les aidant à changer de classe. Elle est également connue comme idole virtuelle. Barry Goodman est un ancien Maître Mirage reconverti en coach pour Fortuna Entertainment. C'est lui qui apprend à Itsuki et son équipe les bases du métier d'idole. Enfin, Maiko Shimazaki, la directrice de l'agence, est une ancienne Maître Mirage et modèle photo. En plus de trouver des castings à Itsuki et ses amis, elle guide les Maîtres Mirage au sein de l' Idolasphère.

Système de jeu

Tokyo Mirage Sessions ♯FE est un jeu vidéo de rôle mélangeant l'univers et le système de combat de Shin Megami Tensei et le système de jeu de Fire Emblem. En combat, le triangle des armes de Fire Emblem et l'exploitation des faiblesses des ennemis de Shin Megami Tensei sont présents. Une option permet au joueur d'ajuster la difficulté du jeu.

Développement
Le jeu est annoncé lors du Nintendo Direct du  sous le titre Shin Megami Tensei X Fire Emblem. Concernant la durée de vie, les développeurs affirment qu'il faudrait trente heures pour terminer les quêtes principales et trente heures supplémentaires pour terminer les différentes quêtes annexes, histoires secondaires et autres contenus déblocables après avoir fini le jeu.

Accueil

Critiques

Le jeu a reçu des critiques globalement très positives. Les sites de compilations de critiques GameRankings et Metacritic lui accordent une moyenne de 82,59 et 81 %, calculées respectivement sur trente-huit et cinquante-neuf critiques.

Ventes
VG Chartz estime les ventes totales du jeu à  exemplaires.

Notes et références

Jeu vidéo de rôle
Jeu Wii U
Jeu Nintendo Switch
Jeu vidéo développé au Japon
Fire Emblem
Shin Megami Tensei
Jeu Atlus
Jeu Intelligent Systems
Jeu vidéo crossover
Jeu vidéo de fantasy
Jeu vidéo sorti en 2015

redpajama_set_name: RedPajamaWikipedia


text:
TMEP 1109.16(c): Requesting an Extension of Time to File a Statement of Use for the Purpose of Compliance with Statutory Filing Requirements
Chapter 1100: Intent-to-Use Applications and Requests to Divide
1109: Statement of Use Under §1(d) of the Trademark Act
1109.16: Correcting Defects in Statement of Use
Previous: §1109.16(b) | Next: §1109.16(d)
1109.16(c) Requesting an Extension of Time to File a Statement of Use for the Purpose of Compliance with Statutory Filing Requirements
In limited circumstances, an applicant may file a request for an extension of time to file a statement of use after filing a statement of use, in order to gain more time to comply with the statutory requirements for filing the statement of use (sometimes called an "insurance" extension request). An applicant may file an extension request after filing a statement of use only if: (1) there is time remaining in the existing six-month period in which the statement of use was filed; (2) no extension request was filed together with the statement of use; and (3) granting the extension would not extend the time for filing the statement of use more than thirty-six months beyond the issuance of the notice of allowance. 37 C.F.R. §2.89(e)(1). See TMEP §1108.03 regarding the time periods and requirements for filing an "insurance" extension request, and TMEP §1108.03(a) regarding the procedures for processing such a request.
The filing of an "insurance" extension request is not in itself a proper response to an Office action, and does not extend the six-month period for response to the Office action. See TMEP §1109.16(d).
Example: Assume that a notice of allowance issues July 3, 2009, the applicant files a statement of use on July 22, 2009, and the examining attorney issues an Office action requiring substitute specimens on August 6, 2009. The applicant may file an "insurance" extension request on or before January 3, 2010, which would give the applicant until July 3, 2010 to make proper use of the mark. However, the applicant must file a response to the Office action on or before February 6, 2010. See TMEP §1109.16(d) for information about responding to an Office action in this situation.


This web page has been prepared to help citizens of the City of Omro understand the basic policies and procedures for running our city government. It is intended to be used for reference purposes only. This section of our site is based on state and federal legislation, general local government reference works, other detailed municipal manuals and similar publications dealing with municipal governments that have been published by the League of Wisconsin Municipalities. Please click on a blue button to see the details each section.
The municipality of the City of Omro is organized as a 4th Class City under Chapter 62 of the Wisconsin State Statutes, which provides for the Mayoral / Council form of government. Under this organization, City government has a legislative branch, belonging exclusively to the City Council, an executive (or administrative) branch, under the direction of a City Administrator-Treasurer, who is hired by the City Council, and a judicial branch administered under the direction of the Municipal Court Judge.
The City Council meets on the first and third Tuesdays of each month at 7:00 PM. If needed, workshops are held at 6:00 PM, prior to the council meeting, for more in depth discussion.
The City Council has established a number of committees, commissions and boards to review city programs, projects and community issues. These groups provide greater community participation and can be a valuable source of information as they make recommendations to the City Council on specific areas. These bodies are all organized either through city ordinance or state statutes, which also prescribe their duties and authority. Unless provided for under state statutes, all meetings are open to the public.


text:
Against the Current by Robert Silverberg
Alice, the Cat Who Was Hounded by Jules Rosenthal
And Then What Happened Paul Revere? by Jean Fritz
Arizona by Clarence Budingham Kelland
Barnyard Dance by Sandra Boynton
Barren Lives by Gracilliano Ramos
Better Not Get Wet, Jesse Bear by Nancy White Carlstrom
Bleach Volume 2 by Tite Kubo
The Boy Who Wanted to be a Fish by Le Grand
Burning Chrome by William Gibson
Can't Wait to Get to Heaven by Fannie Flagg
Cereus Blooms at Night by Shani Mootoo
A Christmas Carol in Prose, Being a Ghost Story of Christmas by Charles Dickens
The Color Purple by Alice Walker
Diary of a Worm by Doreen Cronin and Harry Bliss
Dirk Gently's Holistic Detective Agency by Douglas Adams
The Ebb-Tide by Robert Louis Stevenson
The Eight by Katherine Neville Gag by Lovechild
The Halloween Tree by Ray Bradbury
Hide and Ghost Seek by Carol Thompson
The History of Love by Nicole Krauss
How to Deal with Difficult People by Andrew Costello
I Went to the Animal Fair by William Cole and Colette Rosselli The Key by Joe Vitale
The Long Valley by John Steinbeck
Memoirs of an Invisible Man by H. F. Saint
Motherhood, the Second Oldest Profession by Erma Bombeck
Mousekin's Family by Edna Miller
Mr. Blandings Builds His Dream House by Eric Hodgins
Plato and a Platypus Walk into a Bar by Thomas Cathcart and Daniel Klein
My Summer with George by Marilyn French
Sail Away by Donald Crews
Sailaway Home by Bruce Degen
The Secret River by Kate Grenville
Shooting Polaris by John Hales
Small Pig by Arnold Lobel
The Storm by Sarah Zimmerman
Strange Mr. Satie by M. T. Anderson and Petra Mathers
Turtle's Flying Lesson by Diane Redfield Massie
The Unfinished Revolution by Michael Dertouzos
The Velvet Rage by Alan Downs
Who Goes There? by Dorothy P. Lathrop
Mr. Blandings Builds His Dream House: 10/08/07
In the BookCrossing forums there is a long standing debate about film adaptations of books. With a well-read group of people, there is a lot of reluctance in the group at seeing the film adaptations as they are so often changed. I am firmly in the camp of film adaptation lovers. With so many books published every year it is impossible to read a significant cross section of them. Add up all the previous years and one is quickly faced with an avalanche of books! That's where the film adaptations come in; when I see a film has been inspired by a book I am almost certain to find a copy to read for myself. I've probably read hundreds of books "recommended" to me via the medium of film.
Mr. Blandings Builds His Dream House is one of these books. I saw the 1948 film starring Cary Grant and Myrna Loy on cable (back in the days when we could afford cable) and loved the film. It's actually my second brush with the book (having seen The Money Pit, the 1986 Spielberg version first). But it was the Cary Grant version that made me want to read the book. The next day I purchased a copy for myself.
So, does the book hold up to the movies? Yes. The 1948 versions is a very faithful adaptation in the setting, the plot and the characters. The book though is an even quirkier story than the film, being told in a number of ways: via an omniscient narrator who for the most part follows Mr. Blandings, letters between Blandings and the various workmen involved in the house, newspaper clippings and Mrs. Blandings's diary. The diary entries really caught my attention because they read so much like modern blog entries (minus the emoticons).
Besides the quirky narration, the book is illustrated by William Steig. Steig's cartoons pull out the funniest passages in the chapter and bring them to life with just a few lines.
Comment #1: Thursday, October, 18, 2007 at 10:07:15
I've added your review to the Book to Movie listing."


Horse-drawn carriages in New York City's Central Park New York Central Park Horse Carriage[/caption] date back to the 1880s, and have been a popular tourist attraction since at least World War II. But, that may soon be a thing of the past, if Mayor Bill de Blasio keeps his campaign promise to banish the Central Park carriage horses – he has delayed that action until the end of the year. The proposed ban would require the owners to give up their horses to rescue farms with the assurance that the horses would be permanently retired. And, speaking about being retired, did you know retired drivers pay less for auto insurance?
De Blasio wants to replace the horse-drawn carriages with a fleet of electric, vintage-replica, tourist-friendly vehicles, not just in Central Park, but all over the city. The vehicles would cost $150,000 to $175,000 each. Legislation is still under discussion by the city council; several members are against the ban, saying it will eliminate around 300-400 jobs. New York City has 68 carriages, over 200 horses and 360 drivers. The plan has created an emotionally-charged debate between animal rights groups and carriage owners.
When horse-drawn carriages are mixed with heavy city traffic involving cars, pedestrians, buses, bikes and emergency vehicles, it's an invitation to disaster. Most horses are not comfortable working near cars and trucks. Horses have a unique response to stress – they run.
Over the years, there have been many accidents where both horses and people have been seriously injured and some in which horses have died after they become "spooked" in traffic. In 2010, during the Heritage Days parade in Bellevue, Iowa, one person was killed and two dozen were injured when horses pulling a carriage charged into a crowd of people.
According to animal activists, carriage horses have no place in the city's congested streets. They also cite inhumane conditions endured by the carriage horses.
• Prone to respiratory damage because they are constantly nose-to-vehicles' tailpipes.
• Excessive walking and standing on hard streets results in lameness and hoof deterioration.
• In summer, horses suffering from dehydration or heatstroke can die in just a few hours.
• Many of the stables are firetraps with inadequate sprinkler systems and fire protective devices.
• Many horses have preexisting injuries or arthritis due to their previous lives on the racetrack or on Amish farms.
• When these horses are unable to work the city streets, they are "retired" – many go to auction where their fate is unknown.
• Horses in the field were not examined by a Department of Health and Mental Hygiene veterinarian for an entire year.
• Scheduled stables inspections by the veterinarian, including travel time, were limited to only 25 minutes per location.
• During hot weather, horses on the street did not have ready access to water or there was inadequate shade.
• Poor street drainage left horses standing in pools of dirty water.
It remains to be seen if this popular tourist attraction will still be part of the New York landscape.
In 1989, the City Council passed Local Law 89, which increased liability insurance for carriage owners. Does this cover damages to your car if a spooked horse tramples your fender, or will your car insurance cover it?
Do you think horse drawn carriages have no place being in the big city and should be banned? Feel free to share your thoughts in the comments section below.


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Q: Shortcut or button to toggle space or tab as subsequent indentation character in Notepad++? I would like to have either a keyboard shortcut or a toolbar button that toggles if I use tabs (ie tab for indentation) or make notepad++ use spaces instead.
It would be a nice extra if a toolbar button could be added to toggle showing whitespace characters on/off, but no new lines.
Is this possible?

A: When toggling space/tabs for indentation, would you like the change to only apply to future indentation or all indents, including already existing ones?
To Convert All Existing Spaces to Tabs and Vice Versa
Hotkey: Settings -> Shortcut Mapper -> Main Menu and set hotkeys for the TAB to Space and vice options
Toolbar Button: Install plugin "Customize Toolbar" from Plugins -> Plugin Manager. After installation, Plugins -> Customize Toolbar -> Customize will allow you to add the "Tab to Space" and "Space to Tab" buttons
Toggle indentation character (space or tab) for subsequent indents

*

*Install the Python Script plugin and from its menu, Create new script.

*Choose a file name and save in the given directory

*In the blank script file add: editor.setUseTabs(not editor.getUseTabs()) and save

From the Python Script -> Configuration menu:
Hotkey: Add a menu item and restart N++. From Shortcut Mapper -> Plugin Commands, set a shortcut for your toggle script.
Button: Add a button. Restart N++. If the toolbar button is not clickable, a conflict with the Customize Toolbar plugin is occuring, so you might have to remove that plugin. If there is a way to get  Customize Toolbar and  Python Script  to add buttons to the toolbar simultaneously, I haven't found it.
Toggling Whitespace Character Visibility
Hotkey: Shortcut Mapper -> Main Menu -> "Show Whitespace and Tab"
or
Set Hotkey and/or Toolbar Button for the following N++ Python Script:
# Toggle whitespace visibilty through the following modes
# 0: The normal display mode with white space displayed as an empty background colour
# 1: White space characters are drawn as dots and arrows
# 2: White space used for indentation is displayed normally but after the first visible character, it is shown as dots and arrows
#
# Mode descriptions from http://www.scintilla.org/ScintillaDoc.html#SCI_GETVIEWWS

editor.setViewWS( (editor.getViewWS()+1)%3 )


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HOME / NEWS / DOCTORAL FELLOWS /
Late registrations complicate the start of school for many Boston families
Boston Globe | Features research by Kelley Fong, PhD candidate in Sociology and Social Policy, and Sarah Faude of Northeastern University.
"Two researchers from Harvard and Northeastern universities raised alarms last year about inequities in Boston's school assignment system. After examining late registrations, the researchers concluded 'nearly half of black kindergartners miss the first registration deadline, a rate almost three times higher than their white peers, consigning them to the least preferred schools.'
"'We find that late registration is highly stratified, disproportionately experienced by black and Hispanic children as well as children living in lower-income neighborhoods," the authors, Kelley Fong and Sarah Faude, wrote."
scholar.harvard.edu/kfong ►
Stone PhD Scholars present research at 8th ECINEQ Meeting Paris 2019
Society for the Study of Economic Inequality (ECINEQ) | Stone PhD Scholars Alex Albright (Economics) , Nicholas Short (Government & Social Policy), and Oren Danieli PhD'19 (Business Economics) have been selected to present papers at the eighth meeting of Society for the Study of Economic Inequality (ECINEQ) at the Paris School of Economics, July 3-5, 2019.
Keynote speakers: Stefanie Stantcheva of Harvard University, Marianne Bertrand of University of Chicago, and Thomas Piketty of the Paris School of Economics.
... View program and papers ►
Harvard study shows the predictive power of punishing and toxic environments on children's outcomes
Coverage of new study by Robert Manduca, PhD candidate in Sociology & Social Policy, and Robert J. Sampson, the Henry Ford II Professor of the Social Sciences, now out in the Proceedings of the National Academy of Sciences. They find that neighborhood measures of lead exposure, violence, and incarceration have strong independent predictive power, on top of standard variables, for children's life outcomes.
After Florida's ex-felons won the right to vote, Republicans are taking it away
The Guardian | Michael Morse, PhD candidate in Government, talks with The Guardian about Amendment 4 in Florida. Michael recently completed his JD at Yale Law School and is completing his PhD dissertation on felon disenfranchisement and fines and fees.
Economics, Sexism, Data
NPR Planet Money | Featuring Stone PhD Scholar Alice Wu (Economics). Her research is forthcoming in The Review of Economics and Statistics.
Study finds gap between rich and poor growing regionally, too
Harvard Gazette | A new paper by Robert Manduca, PhD candidate in Sociology & Social Policy, now out in Social Forces.
"In 1980, only about 12 percent of the population lived in places that were especially rich or especially poor," Manduca said. "By 2013, it was over 30 percent. So what we're seeing is a polarization, where people are increasingly living in places that are either much richer or much poorer than the country overall."
While part of that shift is due to sorting — the notion that high-earning people and high-paying jobs have become more geographically concentrated — Manduca shows that the rise in national income inequality can account for more than half of the economic divergence across regions that we observe.
... View the research ▶
How the 1 Percent Is Pulling America's Cities and Regions Apart
CityLab | By Richard Florida.
The two gravest challenges facing America today, economic inequality and geographic divides, are increasingly intertwined. Economic inequality has surged with nearly all the growth being captured by the 1 percent, and the economic fortunes of coastal superstar cities and the rest of the nation have dramatically diverged.
These two trends are fundamental to a new study by Robert Manduca, a PhD candidate in Sociology and Social Policy at Harvard University. The study uses census microdata culled from 1980 to 2013, and finds that America's growing regional divide is largely a product of national economic inequality, in particular the outsized economic gains that have been captured by the 1 percent.
... Read more ▶


I have had the opportunity to serve as a mentor to the founders of GreekPull. GreekPull is an online fundraising platform that meets a lot of the needs of undergraduate chapters. Below is an interview I conducted of them that helps tell their story.
If you know of a product or service that is designed to help those in Greek Life, please send me an email and let me know about it.
GreekPull is an online platform that allows current or alumni members of fraternities, sororities and other on-campus fraternal groups to create and fund projects that support themselves or their local chapter. Whether it's a service project, an expansion project for the group's facility or a special event, GreekPull helps coordinate funding from a broad range of donors.
The process is simple and transparent – local chapter members and alumni are able to create campaigns on the site, and alumni, friends and others can use GreekPull to help fund the project. Incentives can be given for donations as well, and donors are able to track the progress of each campaign as it raises funds.
2) How can it benefit fraternity and sorority chapters?
GreekPull serves as a way to re-engage alumni who have stopped connecting with their Fraternity or Sorority. Our first campaign had a couple of donors give money who had never done so before, because they felt like GreekPull was a way for them to reconnect with other alumni and undergraduate members. It also helps fraternity and sorority chapters do events, fundraisers, and projects that they never thought they could do. It's amazing to see what Greek chapters can do when they no longer have to be constrained with finances.
3) What exactly does a chapter have to do as part of the program?
Create a short video and description about what their raising money for and how they will be using the money. We help promote the campaign by teaming up with national fraternities and sororities as well as using our media channels to promote their campaigns.
4) Why should chapter's choose GreekPull?
GreekPull is specially designed and built for Fraternities and Sororities. Barely any fundraising campaigns related to Greek Life get funded on Indiegogo and Kickstarter because those platforms don't specifically target Greek alumni. Because we first solve the problem of alumni re engagement and then tailor our platform to Greek chapters, we are able to have a much higher success rate for helping fraternities and sororities raise money compared to other tools available.
5) How does a chapter get started in the program?
Contact our head of sales and marketing Eghosa Aihie at eaihie@greekpull.com with your campaign idea, chapter, and University. We then will team up with you and make your campaign a success! Be sure you let them know that you found us on thefraternityadvisor.com.


JOHNSON CITY — The University High boys basketball team clinched the Watauga Valley Conference regular-season title on Thursday night inside Brooks Gym with a hard-fought 36-34 win over Sullivan North.
Marshall Fleenor hit a runner from the right side with 25.6 seconds left that put the Buccaneers up for good, but it was Jake Hubbard who secured a crucial jump ball with 6.2 seconds left that sealed it. On the ensuing inbounds, Hubbard was fouled and hit one of two free throws. North missed a half-court shot as time expired.
Kaleb Meredith — who was presented with a plaque commemorating his 1,000th point before the game — led the Bucs with 13 points and six rebounds. No one scored in double digits for Sullivan North, but Dale Potter and Evan Bishop each had eight points.
Potter hit a 3-pointer with 1:15 left that put the Golden Raiders up 34-33 and — at the rate the game was flowing — looked like it would've been enough for them to pull off a massive upset.
The biggest lead for either team was five points when UH had a 22-17 margin in the early stages of the third quarter.
The Lady Bucs jumped out to a 12-0 lead in the first quarter, and it was all University High in a dominant Watauga Valley Conference win.
The Lady Raiders did not get on the board until 42.6 seconds left in the first quarter, as the UH defense was smothering and North was hoisting up bad shots.
Calli Newberry led the Lady Bucs with 13 points while Sarah Fisher had 12 points and five steals and Gracie Crabtree netted 11. Courtney Hensley finished with 11 rebounds.
The Lady Raiders were led by Hannah Mullins with 11. She hit four of North's five made field goals on the night.
University High improves to 14-13 overall and 2-8 in the league while North drops to 9-13 and 0-10 in the conference. The official game time was one hour and 10 minutes.


text:
The (Old) Farmer's Almanack, 69-78. kiadás
szerző: Robert Bailey Thomas
FEBRUARY hath 29 days.
10 Mo. { rand, 1867.
When clouds frowned the darkest, and perils beset thee,
Till each prop of earth seemed to bend or to break,
Did e'er thy good angel turn off, and forget thee?
The mother her little one then may
forsake.
Aspects, Holidays, Events,
Farmer's Calendar. Weather, &c. 1 Sa. Low tides. Charleston sociocco A CLEAR, cold, bracing air 2 E. 4th Su. af. Èpiph. Purifica. sharpens the appetite. Nothing
like it. Cattle can therefore get 3 Mo. Spanish Inquisition abol- Pleasant
along and do well on a little 4 Tu.
Peter Nassau, colored, died at Pomfret,
Vt., said to be aged 110, 1867. poorer quality of feed now than 5 W. !6 C. (ru. high. but they can later in the season. I 6 Th. Very cold in New England, ther. 16 to mean store cattle, dry cows, and 7 Fr. C in Perigee. {Charles Dickens young stock. There is no econo
my in scrimping cows that are in 8 Sa. 39th. Mariner's compass invented
very milk, now or at any other time. 9 E. Septuagesima Sun. H. ti. If you have swale hay that must Great freshet in New Eng- cold. be consumed, now is the time to
feed it out. 11 Tu. Falling weather for
Didn't you ever 12 W. Oregon admitted, 1859. some days. makes a slice of poor bread go a
notice that a bit of good cheese 13 Th. Dr. Kane, the arctic explorer, died, aged
35, 1857, First Tot. Abst. Society, 1826. little better over the palate ? Just 14 Fr. Št. Val. day. {cars Cook killed, so a few roots make poor hay a 15 Sa. 8 in 8. Önc. L. tides.little more endurable, and the
stock will relish a basket of roots 16 E. Sexagesima Sunday.
now and then. It will be an 17 Mo. 6 84. { Pro. Cong? Search, 2.171, 67. agreeable change from the monot18 Tu. (r. 1. {Sapen. Doner, men med 107, History ony of swale hay and cornstalks, 19 W. & in Perihelion. ( in Ap. and I tell you it pays. Daniel 20 Th. gr. elong. E.
Webster used to say that an ani21 Fr.
mal would fatten on salt hay and may be expected about
turnips; and if it won't fatten on 22 Sa. 6 HC. [Sun. H. ti. swale hay and turnips, it will keep 23 E. Quinquagesima - Shrove in good condition on them, and it 24 Mo. 6 21(Oh O. St. Matt. is all you can expect of store cat25 Tu. 8 8 . Shrove Tuesday. store hogs in good condition on
tle this month. You may keep 26 W. 16 P V. 6! (. 69 C. raw mangolds alone, from Novem27 Th. stat. [Ash Wed. ber to March, with nothing else. 28 Fr. Deerfield, Mass., burned by this Now don't fail to lay in a good 29 Sa. Miss Iucy Aiken, the author- time. supply of them next fall, and try
Mix the muck and loam in with the manure under the barn, pile up the compost heaps, and keep out the surface water. Give poultry plenty of fish offal and scraps.
Indiang, 1704.
, died, 83,
Jit.
O's Declination.
Days of
Rises. 1 Sets. h.
MARCH, Third Month.
Astronomical Calculations.
Days. d. m. Days. d. m.Days. d. m. Days. d. m. Days. d.
7 S.17 7 4 58 13 2 37 19 OS 14 25 2 7 2 6 54 8 4 3+ 14 2 13 20 ON 9 26 2 31 3 6 31 9 4 11 15 1 49 21 0 33 27 2 54 6 8 10 3 47 16 1 26 22 0 57 28
18 5 44 11 3 24 17 1 2 23 1 20 29
41 5 21 12 3 0 18 0 38 24 1 44 30 4 4
First Quarter, 2d day, Oh. 5m., morning.
O Full Moon, 8th day, 3h. 38m.; evening.
(Last Quarter, 15th day, 10h. 45m., evening.
• New Moon, 24th day, 2h. 15m., morning.
) First Quarter, 31st day, 7h. 41m., morning.
9 Length
Day's O! Full Sea,
D's! D
of Days. Incre.
Morn Even
Souths. m. h. 1 SU.6 3515 51 11 16 2 12 12 71 4 41 arm 0 7
5 50 2 Mo.6 34 5 52 11 18 2 14 12 8 5 54 arm 1 12 6 46 3 Tu. 16 325 53 11 21 2 17 12 9 64 69 br. 2 15 7 44 4 W. 16 30 5 54 11 24 2 20112 10 71 8 br. 3 14 8 43 5 Th. 16 28 5 55 11 272 23 12 11 83 9 h'rt 4 8 9 43 6 Fr. 16.2715 57 11 30 2 26 1112 9110 h'rt 4 57 10 41 7 Sa. 16 25 5 58 11 332 29 11 13 10,5 11 bel. 5 40 11 37 8 SU. 6 24 5 59 11 35 2 31 110 111 112 bel. rises. morn. 9 Mo. 6 22 6 0 11 382 34 11 15
rei. 7 10 0 32 10 Tu. 6 2016 1 11 412 37 1016
3 rei. 8 21 1 24 11 W. 6 18 6 2 11 44 2 40 10 17 11 11 rei. 9 28 2 15 12 Th. 16 17 6 4 11 47 2 43 10 18 2 21 sec. 10 31 3 6 13 Fr. 6 15 6 511 502 46 919 23 sec. 11 31 3 55 14 Sa. 6 13 6 6 11 53 2 49 920 3,1 33 thi. morn. 4 44 15 SU.6 126 711 55 2 51. 921
43thi. 0 29 5 33 16 Mo. 6 106 8 11 58 2 54 9 22
50 kn.
1 23 6 21 17 Tu. 6 816 9 12 1 2 57 823
2 13 7 9 18W. 6 6 6 10 12 4 3 0 8 24 7 74 ko. 2 57 7 56 19 Th. 16 56 12 12 7 3 3 8 251 8 84 legs 3 37 8 43 20 Fr. 6 3 6 13 12 10 3 6 7 26 81 91 legs 4 13 9 29 21 Sa. 16 16 14 12 13 3 9 727 9 10 feet 4 46 10 14 22 SU.5 596 15 12 16 3 12 728 101 103 feet 5 17 10 59 23 Mo. 15 586 16 12 18 3 14 6 29 11 114 feet sets. 11 44 24 Tu. 15 566 17 12 21 3 17 6 0 114 h'd 6 50 0 29 25 W. 15 54 6 18 12 24 3 20 6 1
7 52 1 15 26 Th. 5 52 5 19 12 27 3 23 6 2
i n'k 8 56 2. 4 27 Fr. 5 51 6 20 12 29 3 25 5 3 11 1 n'k 10 1 2 54 28 Sa. 15 496 22 12 33 3 295 4 21 21 arm 11 5 3 46 29 SU.5 476 23 12 363 32 5 5 3 37 arm morn. 4 41 30 Mo. 15 45 6 24 12 39 3 35 4 6 38 41 br. 08 5 38
6. kn.
#h'd
time by the forelock, and lay out 3 Tu. 6 C. (ru. high. L. ti. 4 w. ist. Nebraska admitted Sudden driving upon you. Look out now
the work of spring before it comes 5 Th. 16 21. ŞPeace Convention at
for good men to hire. The best 6 Fr. (in Per. C. F. Brown, known as will be engaged if you put it off
"Artemus Ward, d., 1867. to the last minute.
7 Sa. 36th. Aurora Borealis first
Patch up the 8 D. 2d Su. in Lent. 6 8 0 Inf. shingles, and nails; stop the leaks
buildings and fences with hammer, 9 Mo. H. ti. Congridere
, and even friend here and there, fix up the doors and 10 Tu. 6 HÒ. States. letecinde Heme: shutters, and the posts that are 11 W. Wilmot, N. H., aged 100 yrs. 2 mos., 1867. loosened by the frost; overhaul 12 Th. the Monitor andan Mertinge in Very the roots in the cellar, and sort
them over; pick out the rotten 13 Fr.
Charles River, at Boston, crossed cool. ones, and clean up generally with
on ice by sleighs, 1856. 14 Sa. 6 h c. h stat. Mbati Firetrosces air and whitewash. A mixture of 15 D. 3d Sun. in Lent. the Alleghany coal-tar and mortar will stop any
rat holes; they're not apt to gnaw 16 Mo. stat. 6 $ . (r. low.
on it much. Open surface drains 17 Tu. St. Patrick. [Low ti. in your pastures and meadows to 18 W. (in Apogee. Rain, or let off any standing water. Can't 19 Th. {17hne Sand, atorm in New perhaps you lead that brook round on the 20 Fr. Oent. 90. Sp'ng beg. stat. slope of the hill
, and irrigate an
acre or two It has a wonderful 21 Sa. 1320th. Mass. Leg. ratifies Am't
snow. effect on the grass, and a few min22 D. 4th S.in L. 6 § (.68 (utes will often do a good deal. 23 Mo. 621 6. Expect fine Top dress your fields and pastures 24 Tu. 6oc. {Tremtredet mees, Japan and with plaster, or any of the well25 W. 8 in 88. Ånnunciatn. H. ti. known fertilizers you may prefer.
Now is the time. Sow clover on 26 Th. f in Per. { Printing introduced into
lands seeded down last fall. Do 27 Fr. 69(.{Frencacaidise nuania, de la re it if you can on a light snow. It 28 Sa. {Planera, solis- weather for a will guide the eye. The land is 29 D. Šth Sun. in Lent. On its way down. Plough as soon 30 Mo. 329th. Swedenborg died, few days. as the land is ready. Stock needs 31 Tu. HC. ( runs high.
to Constitution, 1867.
care now
APRIL, Fourth Month.
Days. d. m. Days. d. m. Days. d. m. Days. d. m. Days. d.
1 4751 7 7 7 13 9 20 19 11 27 25 13
2 5 14 8 7 30 14 9 41 20 11 47 26 13
9 7 52 15 10 3 21 12 7 27 14
5 6 22 11 8 36 17 10 45 23 12 47 29 14
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O Full Moon, 7th day, 2h. 33m., morning.
Last Quarter, 14th day, 5h. 51m., evening.
New Moon, 22d day, 3h. 36m., evening.
) First Quarter, 29th day, 1h. 34m., evening.
Weet.
Full Sea, e 'sl )
Morn| Even
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Sets. h. m.
8. m.
Souths.
h. m
Length Day's OD
S. A.
m. A. m. 1W. 15 426 26 12 44 3 40 41 81 6 64 br. 2 31 7 33 2 Th. 5 40 6 27 12 47 3 43 3 9 7 7h'rt 2 52 8 30 3 Fr. 5 39 6 28 12 49 3 45 | 310 878 h'rt 3 35 9 25 4 Sa. 15 376 30 12 53 3 49 311 91 91 bel. 4 14 10 19 5 SU.5 35 6 31 12 56 3 52 3 12 10 101 bel. 4 50 11 11 6 Mo. 5 336 32 12 59 3 55 2 1311 114 rei. 5 24 morn. 7 Tu. 5 326 33 13 1 3 57 20111 rei. rises. 02 8 W. 15 30 6 34 13 4 4 0 2 15
8 12 0 53 9 Th. 5 28 6 35 13 7 4 3 116
sec.) 9 15 1 43 10 Fr. 5 27 6 36 13 9 4 5 117 13 14 thi. 10 16 2 33 11 Sa. 15 256 37 13 12 4 8 118 24 25 thi. 11 13 | 3 23 12 SU. 5 23 6 38 13 15 4 11 119 31 thi. morn. 4 13 13 Mo. 5 22 6 40 13 18 4 14 0 20 31 47 kn. 0 6 5 2 14 Tu. 5 20 6 41 13 21 4 17 021 41 5 kn. 0 535 50 15 W. 5 19 6 42 13 23 4 19 F. 22 51 6 legs 1 35 6 37 16 Th. 5 17 6 43 13 26 4 22 0 23 61 7 legs 2 12 7 23 17 Fr. 5 15 6 44 13 29 4 25 1 24 74 74 legs 2 46 8 8 18 Sa. 5 14 6 45 13 31 4 27 1 25 81 8 feet 3 17 8 53 19 SU.5 12 6 46 13 34 4 30 1 26 9 94 feet 3 48 9 37 20 Mo. 5 11 6 47 13 36 4 32 127 91101 h'd 4 18 10 23 21 Tu. 15 9 6 48 13 394 35 128 101 11 h'd 4 47 11 9 22 W. 5 8 6 50 13 42 4 38 20 114 114 n'k sets.'|11 57 23 Th. 5 6 6 51 13 45 4 41 2 112 n'k 7 500 47 24 Fr. 5 56 52 13 47 4 43 2 2
8 57 1 40 25 Sa. 15 3 6 53 13 51 4 47 2 3 1 14 arm 10 2 2 35 26 SU. 5 2 6 54 13 52 4 48 24). 11 21 arm 11 3 3 33 27 Mo. 5 0 6 55 13 55 4 51 3 5 2 31 br. morn. 4 31 28 Tu. 4 59 | 6 56 13 57 4 53 3 6 31 4 br. 0 0 5 29 29 W. 4 58 6 57 13 59 4 55 3 7 457 hört 0 51 6 25


Put the glucose, sugar and water in a pan and heat until 115°C using a sugar thermometer (if you don't have one, the mixture will reach 115°C about 2 minutes after boiling). Let the mixture start to thicken a little but make sure the sugar does not colour.
Place the gelatine sheets in a flat dish, cover with cold water and leave until fully soft. Beat egg whites until stiff. With the sugar now at 115°C let the egg whites cool (5 to 5 minutes).
Add flavours to your taste.
Once the mixture can be worked by hand, use a piping bag to pipe out over a bowl of icing sugar. Cut off at desired length with scissors.
Coat each piece generously in icing sugar so they don't stick together.
See you sweet teeth again soon!


text:
Q: Error locating modules using perlbrew and cpanm I want to use perlbrew and cpanm on my machine. I installed perlbrew like this
curl -L http://install.perlbrew.pl | bash

and sourced ~/perl5/perlbrew/etc/bashrc in my .bashrc. Next I installed perl v5.21.5 and switched to this version.The which perl command points to my perlbrew installation. The same is true for cpanm.
But when I install a perl module like cpanm Mojo Neither the binaries are installed nor the includes can be located. But all tests pass. I looked under ~/perl5/ and could not find the sources. Does anyone had the same issue before? I may have used cpan on my Ubuntu 14.04 before. May this cause any problems? How can I figure out where cpanm put the module?
BTW: I'm using perlbrew version 0.71

A: I solved the problem by deleting everything perl-related in my home directory. The folder ~/.cpan had write-proteced files. Only the sudo user could delete them. I assume I used cpan as root in the past. In addition I deleted ~/.cpanm and ~/perl5. After reinstalling perlbrew, perl and mojolicious, everything worked out of the box.

A: In my case I was just trying to get some perl code running. Many thanks to the #perl channel on irc.freenode.net.
I first used local::lib but may not have fully cleaned up after using it. The modules I needed for the code I was trying to get running would not run with the system perl. It was just too old.
Then I tried perlbrew install perl-5.20.1 and perlbrew install-cpanm. It felt great to start fresh with a known quantity. Yet I found that modules were passing tests and said they were installing but not getting found and used. Dependencies were trying to be continuously reinstalled. Installing the dependencies one at a time didn't even work. It was baffling. Somewhere along the way I read to set PERL_MB_OPT and PERL_MM_OPT though I think I should have also set PERL5LIB with those.
So I started over with perlbrew after rm -rf ~/.cpan ~/.cpanm ~/perl5. Everything just works now. Hurray!

A: Are you running the cpanm command in a new terminal window by chance, if so it might not use the new perl you brewed.
"perlbrew use" only makes the current shell use the brewed perl whereas "perlbrew switch" makes all new shells of the current user use the selected perl.
You should provide the output of "perl -V" and "perlbrew info"
Here is a tip how you can find where cpanm installed a module:
1) install locate (sudo aptitude install locate)
2) run "sudo updatedb" (creates the index used by locate)
3) run "locate Mojo" to see where the files have been created.
Also interesting would be to know which cpanm binary you are using. "which cpanm"
You can install a perlbrew-wide cpanm with "perlbrew install-cpanm"

A: [ I'm going to assume you started a fresh shell (e.g. reopened your terminal or executed exec bash) or sourced ~/perl5/perlbrew/etc/bashrc in your current shell after installing perlbrew ]
Which Perl did you use to install cpanm? cpanm will install modules for the Perl that runs it, which will be the one mentioned on the first line of cpanm if you run it as cpanm ....
Options:

*

*Use cpan instead of cpanm.

*Install cpanm using your newly installed Perl.

*Use perl -S cpanm ... as a workaround.


text:
package net.sourceforge.plantuml.activitydiagram3.ftile;

import java.util.Collection;
import java.util.List;

import net.sourceforge.plantuml.ISkinParam;
import net.sourceforge.plantuml.Url;
import net.sourceforge.plantuml.activitydiagram3.Branch;
import net.sourceforge.plantuml.activitydiagram3.ForkStyle;
import net.sourceforge.plantuml.activitydiagram3.Instruction;
import net.sourceforge.plantuml.activitydiagram3.LinkRendering;
import net.sourceforge.plantuml.activitydiagram3.PositionedNote;
import net.sourceforge.plantuml.cucadiagram.Display;
import net.sourceforge.plantuml.cucadiagram.Stereotype;
import net.sourceforge.plantuml.graphic.StringBounder;
import net.sourceforge.plantuml.graphic.USymbol;
import net.sourceforge.plantuml.graphic.VerticalAlignment;
import net.sourceforge.plantuml.graphic.color.Colors;
import net.sourceforge.plantuml.style.Style;
import net.sourceforge.plantuml.ugraphic.color.HColor;

public interface FtileFactory {

	public StringBounder getStringBounder();

	public ISkinParam skinParam();

	public Ftile start(Swimlane swimlane);

	public Ftile stop(Swimlane swimlane);

	public Ftile end(Swimlane swimlane);

	public Ftile spot(Swimlane swimlane, String spot, HColor color);

	public Ftile activity(Display label, Swimlane swimlane, BoxStyle style, Colors colors, Stereotype stereotype);

	public Ftile addNote(Ftile ftile, Swimlane swimlane, Collection<PositionedNote> notes,
			VerticalAlignment verticalAlignment);

	public Ftile addUrl(Ftile ftile, Url url);

	public Ftile decorateIn(Ftile ftile, LinkRendering linkRendering);

	public Ftile decorateOut(Ftile ftile, LinkRendering linkRendering);

	public Ftile assembly(Ftile tile1, Ftile tile2);

	public Ftile repeat(BoxStyle boxStyleIn, Swimlane swimlane, Swimlane swimlaneOut, Display startLabel, Ftile repeat,
			Display test, Display yes, Display out, Colors colors, Ftile backward, boolean noOut,
			LinkRendering incoming1, LinkRendering incoming2);

	public Ftile createWhile(LinkRendering outColor, Swimlane swimlane, Ftile whileBlock, Display test, Display yes,
			HColor color, Instruction specialOut, Ftile backward, LinkRendering incoming1, LinkRendering incoming2);

	public Ftile createIf(Swimlane swimlane, List<Branch> thens, Branch elseBranch, LinkRendering outColor,
			LinkRendering topInlinkRendering, Url url);

	public Ftile createSwitch(Swimlane swimlane, List<Branch> branches, LinkRendering afterEndwhile,
			LinkRendering topInlinkRendering, Display labelTest);

	public Ftile createParallel(List<Ftile> all, ForkStyle style, String label, Swimlane in, Swimlane out);

	public Ftile createGroup(Ftile list, Display name, HColor backColor, PositionedNote note, USymbol type,
			Style style);

}

redpajama_set_name: RedPajamaGithub


Pen and brown ink with brown wash; ruled framing-lines in pen and brown ink.
Inscription Content: Inscribed verso, in graphite, upper right: '5'; lower right: '13 and 6 Sheet'; lower left: '50'.
In Hind as Jan Victors. See Hind for a discussion of the attribution.
The drawing stands at the centre of an attributional debate concerning a group of drawings all by the same hand. Mostly representing biblical subjects, the drawings are stylistically distinctive: in general they have loose, though competent outlines which are almost invariably followed up with liquid, heavily accented, corrective pen-strokes, which sometimes suggest shadows, but sometimes work against the logical fall of light. Considerable use is also made of the tip of the brush to accent and extend the outlines yet further, as well as of deft, confident and sensitively variegated applications of wash.
Of the more than 55 drawings in the group known, some of which are directly inspired by Rembrandt, only the present example is related to a finished work, a painting now in the Dordrechts Museum. Once accepted as a signed work by Nicolaes Maes, the painting is now believed possibly to be by another Dordrecht painter, Maes' stepson, Justus de Gelder (1650-after 1707?). This attribution is based on its stylistic similarity to the only signed painting by De Gelder, which was discovered in 1996. As a contender for the authorship of the painting of the 'Hurdy-Gurdy Man', he is consequently also regarded as the possible author of this and all the other drawings in the group. The signed painting, which represents 'Two Boys playing on a Bridge', is dated 1671, and it is possible that the British Museum drawing, and the related painting in Dordrecht, date from approximately the same time. Another possible terminus a quo results from the conjecture that Maes may himself have painted the figure of a woman looking out of a window in the Dordrecht painting. As Maes left Dordrecht for Amsterdam in 1674, the drawing and the related painting may date from c.1671-74. However, this surmise and the attribution are sufficiently conjectural to encourage reserve, and this and another drawing in the group, cat. nos.9 (1925,1114.1) and, more tentatively, cat. no.11 (1895,0915.1151), are here categorised as from the "School of Maes (Justus de Gelder?)". The reasons for this reserve are the scarcity of knowledge concerning other possible contenders, and the fact that the related painting in Dordrecht is not signed (only another that stylistically resembles it in general terms).
The character of the relationship between the drawing and the painting also undermines confidence in the attribution. The drawing, like most in the group, has a finished, pictorial quality that is at odds with a preparatory function. Many historical and biblical scenes of this type survive by Rembrandt and his pupils, but they are usually regarded as independent creations and are rarely connected with finished paintings. Furthermore, the relationship between the drawing and the painting is unusual, because every figure is changed; yet there are no pentimenti in the drawing, and in the painting the figures all become more rigid and static, as if a lively genre scene had been changed into a semi-formal family portrait with genre elements. The architectural features also underwent significant changes, and a seated boy was added in the right foreground of the painting. For these reasons, the drawing and the painting may be by different hands. One – perhaps the painting (which may well be by De Gelder) – may derive from the other, or both may derive from another source, now unknown. If the painting is by Justus de Gelder, it may be based on a painting or sketch by his stepfather, Nicolaes Maes.
The composition may reflect knowledge of the painting of 1608 by David Vinckboons, now in the Rijksmuseum, Amsterdam.
A copy of the drawing is in Edinburgh.
 Sumowski, 1979 etc., nos.1768 (the present work) and 1904x – 1956ax, describes 55 drawings. He mentions seven others that are lost.
 Sumowski, 'Gemälde', III, 1983, p.2019, no.1360, repr.; Krempel, 2000, no.E3, repr. fig.408.
 Krempel, 2000, p.364, under no.E 3, suggests that the figure at the window is a portrait, and that it was added by Maes.
 Inv.A2401. The comparison was made by Hellerstedt, 1981 (see Lit. below).
 See Edinburgh, 1985, I, p.49, no.D.1814, repr. II, fig.328.
Robinson, 1869/76, no.842 /867 (Victors); London, 1915, p.94, no.1, repr. pl.LXIII (Victors; traditional attribution, supported by analogies with his paintings); Van Dyke, 1927, p.125 (possibly Victors); Paris, 1933, p.54, under no.1281 (perhaps Victors); Hind, 1936, p.88 (attributes to Maes; relates to signed painting with Schaeffer [now Dordrecht Museum]); Amsterdam, 1942, p.49, under no.98; Bernt, 1957, II, no.636, repr. (Victors); Sumowski, 1963[I], p.98 (by Victors but connected with Maes painting in Dordrecht); Sumowski, 1964[II], p.198, n.43; Exh. Cambridge, 1966, under no.45, n.26 (as Sumowski, 1963[I]); Hellerstedt, 1981, pp.19-21, repr. fig.7 (Victors? compares for subject Benesch 750; relates to Maes painting, and hurdy-gurdy man to figure in Vinckboons painting in Rijksmuseum); Sumowski, 'Gemälde', III, 1983, p.2019, under no.1360 (c.1656-8; otherwise as Hind, 1936); Sumowski, 1979 etc., VIII, 1984, p.3980, no.1768, repr. (Maes, for Dordrecht painting); Edinburgh, 1985, I, p.49, under no.D.1814; Exh. New York-Fort Worth-Cleveland, 1990-91, under no.39 (as Sumowski, 1979 etc.); Exh. Dordrecht, 1992-3, p.244, repr. fig.1 (Maes; entry by Wieseman notes differences to Dordrecht painting); Robinson, 1996 diss., pp.99 and 140-1 (anon. pupil or close follower of Maes, also responsible for Dordrecht painting; unusual for a preparatory sketch by Maes to be so complete); Robinson, 1999, p.247 (as in 1996); Krempel, 2000, p.364, under no.E3, repr. fig.407 (not Maes; perhaps Justus de Gelder).
Sybouts (according to Leembruggen sale catalogue); Gérard Leembruggen; his sale, Amsterdam, Roos, Engelberts, Lamma and Roos, 5ff. March, 1866, lot 717 (as Victors), bt for Malcolm, who paid £2-17-3 (according to marked copy of Robinson, 1876, in the British Museum); John Malcolm of Poltalloch; purchased with the Malcolm collection, 1895.
1992, BM, Drawings by Rembrandt and his Circle (not in catalogue, as Maes).


Over the past century, the mouse has developed into the premier mammalian model system for genetic research. Scientists from a wide range of biomedical fields have gravitated to the mouse because of its close genetic and physiological similarities to humans, as well as the ease with which its genome can be manipulated and analyzed.
Although yeasts, worms and flies are excellent models for studying the cell cycle and many developmental processes, mice are far better tools for probing the immune, endocrine, nervous, cardiovascular, skeletal and other complex physiological systems that mammals share. Like humans and many other mammals, mice naturally develop diseases that affect these systems, including cancer, atherosclerosis, hypertension, diabetes, osteoporosis and glaucoma. In addition, certain diseases that afflict humans but normally do not strike mice, such as cystic fibrosis and Alzheimer's, can be induced by manipulating the mouse genome and environment. Adding to the mouse's appeal as a model for biomedical research is the animal's relatively low cost of maintenance and its ability to quickly multiply, reproducing as often as every nine weeks.
Mouse models currently available for genetic research include thousands of unique inbred strains and genetically engineered mutants. There are mice prone to different cancers, diabetes, obesity, blindness, Lou Gehrig's disease, Huntington's disease, anxiety, aggressive behavior, alcoholism and even drug addiction. Immunodeficient mice can also be used as hosts to grow both normal and diseased human tissue, a boon for cancer and AIDS research.
In the early days of biomedical research, scientists developed mouse models by selecting and breeding mice to produce offspring with the desired traits. Researchers also learned to produce useful, new models of genetic disease quickly and in large numbers by exposing mice to DNA-damaging chemicals, a process known as chemical mutagenesis.
In recent decades, researchers have utilized an array of innovative genetic technologies to produce custom-made mouse models for a wide array of specific diseases, as well as to study the function of targeted genes. One of the most important advances has been the ability to create transgenic mice, in which a new gene is inserted into the animal's germline. Even more powerful approaches, dependent on homologous recombination, have permitted the development of tools to "knock out" genes, which involves replacing existing genes with altered versions; or to "knock in" genes, which involves altering a mouse gene in its natural location. To preserve these extremely valuable strains of mice and to assist in the propagation of strains with poor reproduction, researchers have taken advantage of state-of-the-art reproductive technologies, including cryopreservation of embryos, in vitro fertilization and ovary transplantation.
The Jackson Laboratory, a publicly supported national repository for mouse models in Bar Harbor, Maine, has played a crucial role in the development of the mouse into the leading model for biomedical research. Established in 1929, the non-profit center pioneered the use of inbred laboratory mice to uncover the genetic basis of human development and disease. In fact, the famous "Black 6" or C57BL/6J mouse strain whose genome is the focus of the landmark sequencing effort was developed in the early 1920s by The Jackson Laboratory founder Clarence Cook Little.
Today, researchers at The Jackson Laboratory pursue projects in areas that include cancer, development and aging, immune system and blood disorders, neurological and sensory disorders, and metabolic diseases. Informatics researchers work with the public sequencing consortium to curate and integrate the sequenced mouse genome data with the wealth of biological knowledge collected in Jackson's Mouse Genome Informatics resource.
In addition, The Jackson Laboratory distributes 2,700 different strains and stocks as breeding mice, frozen embryos or DNA samples. In FY 2002 alone, the lab supplied approximately 2 million mice to the international scientific community.
Down Syndrome - One of the most common genetic birth defects in humans, occurring once in every 800 to 1,000 live births, Down syndrome results from an extra copy of chromosome 21, an abnormality known as trisomy. The Ts65Dn mouse, developed at The Jackson Laboratory, mimics trisomy 21 and exhibits many of the behavioral, learning, and physiological defects associated with the syndrome in humans, including mental deficits, small size, obesity, hydrocephalus and thymic defects. This model represents the latest and best improvement of Down syndrome models to facilitate research into the human condition.
Cystic Fibrosis (CF) - The Cftr knockout mouse has helped advance research into cystic fibrosis, the most common fatal genetic disease in the United States today, occurring in approximately one of every 3,300 live births. Scientists now know that CF is caused by a small defect in the gene that manufactures CFTR, a protein that regulates the passage of salts and water in and out of cells. Studies with the Cftr knockout have shown that the disease results from a failure to clear certain bacteria from the lung, which leads to mucus retention and subsequent lung disease. These mice have become models for developing new approaches to correct the CF defect and cure the disease.
Cancer - The p53 knockout mouse has a disabled Trp53 tumor suppressor gene that makes it highly susceptible to various cancers, including lymphomas and osteosarcomas. The mouse has emerged as an important model for human Li-Fraumeni syndrome, a form of familial breast cancer.
Glaucoma - The DBA/2J mouse exhibits many of the symptoms that are often associated with human glaucoma, including elevated intraocular pressure. Glaucoma is a debilitating eye disease that is the second leading cause of blindness in the United States.
Type 1 Diabetes - This autoimmune disease, also known as Juvenile Diabetes, or Insulin Dependent Diabetes Mellitus (IDDM), accounts for up to 10 percent of diabetes cases. Non-obese Diabetic (NOD) mice are enabling researchers to identify IDDM susceptibility genes and disease mechanisms.
Type 2 Diabetes - A metabolic disorder also called Non-Insulin Dependent Diabetes Mellitus (NIDDM), this is the most common form of diabetes and occurs primarily after age 40. The leading mouse models for NIDDM and obesity research were all developed at The Jackson Laboratory: Cpefat, Lepob, Leprdb and tub.
Epilepsy - The "slow-wave epilepsy," or swe, mouse is the only model to exhibit both of the two major forms of epilepsy: petit mal (absence) and grand mal (convulsive). It shows particular promise for research into absence seizures, which occur most often in children.
Heart Disease - Elevated blood cholesterol levels and plaque buildup in arteries within three months of birth (even on a low-fat diet) are characteristics of several experimental models for human atherosclerosis: the Apoe knockout mouse and C57BL/6J.
Muscular Dystrophy - The Dmd mdx mouse is a model for Duchenne Muscular Dystrophy, a rare neuromuscular disorder in young males that is inherited as an X-linked recessive trait and results in progressive muscle degeneration.
Ovarian Tumors - The SWR and SWXJ mouse models provide excellent research platforms for studying the genetic basis of ovarian granulosa cell tumors, a common and very serious form of malignant ovarian tumor in young girls and post-menopausal women.


The Concerts of Cushions is the new musical highlight in the Ludwigsburg Summer 2017. In the museum courtyard, DO THE DO presents national and international musicians of different genres, singers songwriters of folk, indie to electro pop. Guests receive a comfortable cushion at the entrance and are free to choose their own space in the courtyard. In the sea of pillows and fairy lights in a cosy atmosphere, the concerts of cushions to discover an array of new music.


text:
Nilasera opalina är en fjärilsart som beskrevs av Moore 1883. Nilasera opalina ingår i släktet Nilasera och familjen juvelvingar. Inga underarter finns listade i Catalogue of Life.

Källor

Juvelvingar
opalina


text:
Home > News > Deals & People > Two Sales Directors Join MassMutual Retirement Services
Deals & People August 3, 2011
Two Sales Directors Join MassMutual Retirement Services
MassMutual has hired Garrett Carlough and Andrew Hanlon as sales directors to its Retirement Services sales and client management organization.
Carlough and Hanlon will report to Jonathan Shuman, national sales leader for MassMutual's Retirement Services Division.
Carlough, based in New York City, will provide additional coverage for clients in Manhattan, Long Island, Westchester and Rockland counties and northern New Jersey. He comes to MassMutual from Principal Financial Group.
Hanlon is based in Boston, and will provide increased coverage for the eastern Massachusetts, Rhode Island, New Hampshire and Maine territories. He was most recently a key account manager in MassMutual's distribution support organization, and previously held positions in operations, implementation and sales at Putnam Investments.
"Our retirement services business is experiencing exceptional growth," said Hugh O'Toole, senior vice president of sales and client management for MassMutual's Retirement Services Division. "We will continue to grow our sales and relationship management organizations to ensure exceptional support in all the markets we serve."
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