text:
Synthesis and Immunological Properties Tumor Associated Carbohydrate Antigens based Anticancer Vaccines
Mono-TACA vaccines based on protein-carriers
Clustered mono-TACA vaccines based on protein-carriers
Hetero-TACA vaccines based on protein-carriers
Problems associated with protein carriers
Alternatives to protein-carrier delivery
Two-component (TACA-CD4+), fully synthetic anti-cancer vaccines
Two-component (TACA-lipopeptide), fully synthetic anti-cancer vaccines
Multi-component, fully synthetic anticancer vaccines
Leclerc and co-workers paved the way for the fully-synthetic approach in TACA-based anticancer vaccines. In 1997, they prepared a glyco-dendrimer, namely multiple antigen glycopeptide (MAG), displaying the Tn antigen in its α-GalNAc-Ser form.Bay et al., 1997 Inspired by the multiple antigen peptide (MAP) described by Tam in 1988,Posnettz et al., 1988 the MAG construct (58, figure 8) is composed of a core scaffold featuring oligomeric branched lysines (in blue), which are functionalized with four peptide fragments from poliovirus (PV103-115 : KLFAVWKITYKDT, in green) as CD4+ epitopes, and four Tn antigen copies (in orange).Leclerc et al., 1991
Figure 8. Multiple antigen glycopeptide (MAG) by Leclerc and co-workers (58), and protected (Ser)Tn building block (59).
The synthetic strategy for assembling the MAG involved a conventional solid-phase peptide methodology which started with the attachment of the β-alanyl spacer on the Wang resin (Synthesis not shown). The subsequent coupling with two levels of Fmoc-Lys(Fmoc)-OH residues, afforded a dendrimer-like core scaffold with four amino groups, which were further elongated with protected AAs of the PV103-115 sequence. The protected building block 59 was ultimately conjugated to the PV's amino termini in a divergent manner, following cleavage from the resin and global deprotection, to afford fully synthetic vaccine prototype 58. It is noteworthy mentioning that the molecular weight of the entire construct corresponds to 8014 Da, allowing a precise characterization by mass spectrometry and analytical RP-HPLC. Moreover, the TACA (i.e. (Ser)Tn) ratio over the entire vaccine corresponds to 0.15 in terms of molecular weight. Performing the same operation on semi-synthetic vaccine prototype 30 (Scheme 4), knowing that n = 648 (conjugation ratio) and M.W. of KLH ranges between 6000-7500 kDa, the resulting ratio corresponds to 0.08, thus highlighting not only the superior precision of the MAG construct, but also its improved TACA ratio over the entire molecule.
Preliminary B-cell antigenicity studies showed the reactivity of construct 59 towards two well-characterized anti-Tn mAbs : 83 D4 (IgM) and MLS 128 (IgG). Interestingly, T-cell antigenicity trials showed that the presence of the Tn antigen in construct 58 dramatically increased the presentation of the PV peptide by MHC molecules, since the same construct devoid of the Tn moiety necessitated a 10000-fold increased concentration to stimulate T-cells to the same extent.Lo-Man et al., 1999 The authors suggested that such behavior could be the consequence of a specific GalNAc-mediated receptor cross-linking, which also causes the endocytosis of the construct by APCs. Immunization studies were carried out in three different strains of mice (i.e. BALB/c, DBA/2 and SJL/J) with 50 µg of 58 plus 1 mg of alum. Post-immunization sera from mice inoculated with construct 58, but not those treated with a negative control lacking the Tn moiety, produced high titers of anti-Tn IgG antibodies (mainly IgG1) with similar reactivity towards human tumor cell lines (i.e. human Jurkat T-cell lymphoma cell line and LS180 adenocarcinoma cell line), compared to mAb MLS 128.Numata et al., 1990Nakada et al., 1991. Moreover, immunization of DBA/1 mice, a strain which is not responsive towards PV peptide, did not develop any anti-Tn antibodies following immunization with 58, thus confirming the occurrence of a T-cell dependent immune response in the context of this anti-Tn antibody response. Finally, the immunotherapeutic effect of construct 58 was tested in BALB/c mice grafted with TA3/Ha to investigate the survival rate and the resistance to tumor challenge, showing statistically significant differences between treated mice and mocks.
Following the good results obtained with clustered carbohydrate antigens, the same group reported the immunological evaluation of a clustered version of the MAG compound 58. The structure of this second generation construct integrates a tri-Tn motif at the end of each PV sequence, where the α-GalNAc moiety is grafted onto a Ser-Thr-Thr (STT) sequence (60, figure 9).Lo-Man et al., 2001
Figure 9. Tn-clustered multiple antigen glycopeptide (MAG) by Leclerc and co-workers (60).
The study highlighted that the clustered STT glycosylated sequence was the most efficient for the induction of anti-Tn antibodies able to recognize a large variety of GalNAc glycosylated MUC-1 sequences, broadening the spectrum of recognition for native forms of Tn. The ability to induce anti-Tn IgG antibodies with a mild adjuvant like alum, compared to Tn-KLH conjugates which need a stronger adjuvantation (QS-21), and also in the frame of other adjuvant settings (e.g. CpG oligonucleotides, lipopeptide adjuvants), emphasizes the validity of this fully-synthetic approach. It is important to mention that no evidence of antibodies directed against the poly-lysine core scaffold has been reported, and no adverse reaction was observed in all experimental settings.Lo-Man et al., 2004
In 2015 compound 60 entered in a phase I clinical study, thanks to its promising pre-clinical results. This study involved patients with non-metastatic, HER2 negative, localized breast cancer at high-risk of relapse.Laubreton et al., 2016
In 2005, Dumy, Renaudet, and co-workers, inspired by the work of Leclerc's group, gave their first contribution to the fully-synthetic approach by exploring the utilization of the cyclic RAFT template as an innovative scaffold to present B- and T-cell epitopes in a multivalent and topologically separated fashion.Grigalevicius et al., 2005 Conceived by Mutter and co-workers, the RAFT (regioselectively addressable functionalized template) scaffold was initially designed as tool for directing covalently attached building blocks into characteristic folding topologies (introducing the concept of template-assembled synthetic proteins : TASP).Mutter et al., 1989 RAFTs are topological templates composed by a backbone-cyclized decapeptide which contain two Pro-Gly residues as β-turn inducers, able to stabilize their conformation in solution and to provide a quite rigid structure, where the side chains of lysine residues point in two distinct directions, defining an upper and lower domain (Figure 10).
Figure 10. RAFT scaffold by Mutter, Dumy, and co-workers. a) General structure representation. b) 3D model representation with four sugar residues in the upper domain and two peptide sequences in the lower domain.
These scaffolds have served for the construction of synthetic vaccines, and they have also demonstrated to be useful tools as vectors in cancer therapy, and for the study of G-quadruplex folding.Bonnat et al., 2017 The interesting features of RAFT scaffolds are not limited to their conformational stability and topology. Indeed, they represent attractive scaffolds for the construction of anticancer vaccines also thanks to other advantages : (i) they are easily synthesized via standard solid phase peptide synthesis, (ii) their in-vivo stability and compatibility, due to the cyclic structure and functionalized AA's side chain make them less prone to undergo protease-mediated hydrolysis ; (iii) the possibility to selectively functionalize the two distinct domains (i.e. upper and lower domains) of the scaffold, with reduced interference phenomena between different ligands (e.g. B-cell epitopes in the upper domain and T-cell epitopes in the lower domain) ; (iv) the ease to tailor other structural and spatial parameters, by increasing the cyclopeptide core size or by introducing other multivalent elements in both convergent and divergent manners.
The first generation of fully-synthetic anticancer vaccine prototypes conceived by Dumy, Renaudet and co-workers involved the clustered presentation of four Tn analogues, on the upper domain of the scaffold, and one (61) or two (62) PV103-115 peptide sequences on the lower domain (Figure 11).Grigalevicius et al., 2005
Figure 11. First generation of fully-synthetic Tn-based anticancer vaccine prototypes by Dumy and Renaudet.
A second aspect of this approach relies on the utilization of an iterative oxime ligation protocol, which has demonstrated to be efficient and chemoselectively compatible with a wide range of chemical functions, allowing the ligation between unprotected fragments without the need of coupling agents.Forget et al., 2001 Pifferi et al., 2017 Such a strategy requires the preparation of the different modules (e.g. B-cell epitopes, scaffold and T-cell epitopes) bearing aldehyde and aminooxy functional groups as counterparts for their condensation into the hydrolytically stable oxime bond. The aminooxylated αGalNAc 63 (Scheme 11) has been chosen as structurally simplified carbohydrate analog of the native Tn antigen (Ser/Thr-αGalNAc). This choice was supported by literature reports, where other carbohydrate-based Tn analogs showed similar antigenicity compared to the native form.Cipolla et al., 2002 Similarly, the RAFT scaffold 64 and aldehyde-bearing T-cell epitope 65 represents key building blocks for the construction of such vaccine prototypes (Scheme 11). Since this chemical strategy will be discussed more in detail in the following sections, in Scheme 11 we reported an essential synthetic scheme for the assembly of vaccine prototype.Grigalevicius et al., 2005
Scheme 11. Essential synthetic pathway for the construction of synthetic vaccine prototype 61. Conditions : [a] 65 (1.1 eq.), AcONa buffer (pH 4.0, 100 mM), r.t., 24 h, 78% ; [b] NaIO4, PBS (pH 7.3, 10 mM), r.t., 5 h, 86% ; [c] 63 (9.3 eq.), AcONa buffer (pH 4.0, 100 mM), r.t., 36 h, 66%.
Intermediate 64 (Scheme 11), bearing four serine residues in the upper domain and one aminooxy function in the lower domain, underwent oxime ligation with aldehyde-bearing CD4+ peptide 65 in acetate buffer at pH 4.0 for 24 hours at room temperature, to afford scaffold 66. The serine residue act as masked aldehyde function, indeed treatment of 66 with sodium periodate afforded four α-oxo-aldehydes (not shown),El-Mahdi & Melnyk, 2013 prone to react via oxime ligation with α-aminooxy-GalNAc 63. Fully-synthetic vaccine prototype 61 was obtained in good yields (44%, from intermediate 64), excellent purity and was easily characterized by mass spectrometry and analytical RP-HPLC.
B-cell antigenicity was assessed by ELISA using two Tn-specific mAbs 6E 11 (IgG3) and an 83 D4 (IgM) : compounds 61 and 62 both shown their binding abilities towards the two mAbs, but not control molecules lacking the sugar moiety or presenting a different saccharide (i.e. GlcNAc). The RAFT scaffold has proved effective for presenting the oxime-linked Tn-antigen's saccharide moiety (i.e. GalNAc), in a clustered manner, to mAbs which are reactive with the naturally occurring antigen. Therefore, the "unnatural" Tn derivative 63 represent a suitable model for humoral stimulation.
In-vitro T-cell antigenicity assays indicated an enhanced IL-2 production caused by prototypes 61 and 62 : they induced T-cell stimulation at a 10000-fold inferior concentration, compared to their unglycosylated analogs bearing the PV peptide but not the saccharide moiety. This result confirms previous observations regarding the enhanced T-cell stimulation induced by peptides bearing a GalNAc moiety, as the Tn antigen.Madsen, Pedersen & Wandall, 2013
Immunogenicity of compounds 61 and 62 was tested in BALB/c mice by administering 10 µg of the compound in alum. Collected post-immunization sera contained IgG antibodies which were able to recognize the glycosylated RAFT (containing four Tn residues) but not the naked RAFT scaffold, assessing the non-antigenicity of the cyclodecapeptide platform. The antibody response of compound 62, displaying two copies of the PV103-115 peptide did not result increased compared to its homolog 61, suggesting the relevance of the clustered B-cell epitope presentation for an effective humoral response. The obtained IgG antibodies were reactive towards the human Jurkat tumor cell line expressing the Tn antigen. These preliminary results opened interesting perspectives for the utilization of such a modular strategy for the synthesis of multicomponent vaccine constructs. Indeed, the following generations of therapeutic vaccines focalized their design on integrating new modules such as CD8+ epitopes and internal adjuvants.
Following the preliminary results obtained in one of their former studies,Keil, Claus, Dippold & Kunz, 2001 Kunz and co-workers reported the synthesis and immunological evaluation of a two-component fully-synthetic vaccine construct incorporating : (i) the STn antigen along with the MUC-1 sequence GVT•SAPDTRPAP (• = glycosylation site) as B-cell epitope, and (ii) the OVA323-339 sequence (ISQAVHAAHAEINEAGR) as CD4+ TH epitope (71, Scheme 12b).Dziadek, Kowalczyk & Kunz, 2005 The strategy adopted for the vaccine construct assembly started with a solid phase peptide synthesis (SPPS) protocol on resin 67, in which glycopeptide building block 15 (Scheme 3) was integrated. Subsequent cleavage from the solid support and purification by preparative RP-HPLC afforded protected intermediate 68 in 45% overall yield (Scheme 12a). The elongation of resin 69 proceeded to give the desired OVA323-339 sequence, and a triethylene glycol spacer was attached, following a similar procedure that previously described in Scheme 3, to give 70. The final steps involved the solid phase coupling of 68, activated with HATU/HOAt, to the polymer-bound sequence 70, following cleavage from the resin and subsequent global deprotection, to afford pure compound 71 in 19% overall yield (from 69) (Scheme 12b).
Scheme 12. a) Synthesis of protected glycopeptide 68. b) Synthesis of vaccine construct 71. Conditions : [a] 68 (1.05 eq.), HATU, HOAt, NMM in DMF, r.t., 16 h ; [b] TFA/TIS/H2O (15:0.9:0.9), r.t., 2 h, 42% over two steps ; [c] H2, Pd/C (10%), r.t., 21 h ; [d] NaOMe, MeOH, r.t., 16 h, 43% over two steps. SPPS : 1) Fmoc removal : 20% piperidine in NMP ; 2) AAs coupling : Fmoc-AA-OH, HBTU, HOBt, DIPEA in DMF : 3) capping : HOBt (cat.), Ac2O, DIPEA in NMP. Trt = triphenylmethyl ; Pmc = pentamethylchroman-6-ylsulfonyl.
Immunization studies were carried out on transgenic mice (DO11.10), whose T cells express a specific receptor which binds to the OVA323-339 epitope presented on MHC-II molecules. Compound 71 was administered to three mice at the dose of 10 µg, in the presence of complete Freund's adjuvant (CFA). Only one out of three mice exhibited a considerable concentration of MUC1-specific antibodies, while mocks generated only minor, unspecific reactions. The authors suggested that although DO11.10 mice are genetically identical, their individual immune response can differ, so the lower response of the other two immunized mice (comparable with mocks) was not uncommon. Nevertheless, the specificity of the produced IgG antibodies was assessed in a neutralization assay, in which neither a similar sialylated MUC-4 sequence, nor a MUC-4 peptide sequence, nor the naked GVTSAPDTRPAP sequence, were capable to interact with the antibody. Conversely, the MUC-1 sequence GVT(STn)SAPDTRPAP contained in vaccine 71 almost completely neutralized the serum. The strategy proposed by Kunz and co-workers represents another encouraging result for the development of efficient fully-synthetic anticancer vaccines based on TACAs.


text:
Locked down? Start home-based horticulture for good health
Sadiqur Rahman
29 April, 2020, 12:20 pm
Last modified: 30 April, 2020, 11:44 am
Terrarium Dhaka: Capturing the marvelous ways of nature
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Short of funds, a promising rooftop farming training program wilts
At a time when social life and economy have stopped due to lockdown, rooftop gardening to grow vegetables has emerged as sort of a necessity
Gardening on the rooftop or in the veranda is a fun and relaxing way to get rid of inertia. Photo: Noor-A-Alam
Motia Hossain, a retired government officer living at New Eskaton in Dhaka, found it difficult to source her preferred organic vegetables from different shops. Hence, she built a rooftop garden three years ago.
Sometimes, her two daughters taste the vegetables she grows. But now they are insisting that she expands the garden on her 2,000 sqft roof because they cannot buy vegetables as frequently as they could a month ago, because of the lockdown.
"My daughters – who are married – are now planning to build a rooftop garden," Motia said.
Gardening on the rooftop or in the veranda may be a fun and relaxing way to get rid of inertia. But at a time when social life and economy have stopped due to the lockdown, home-based horticulture has emerged as sort of a necessity.
To check the spread of the novel coronavirus, the government has imposed a nationwide shutdown. Every day, as new cases emerge, more areas in cities and villages are put on lockdown.
If farmers cannot go out for cultivation or fail to transport their produces to markets, or if consumers cannot go out for shopping, the demand and supply chain becomes disrupted. This severely impacts the market of perishable items, particularly vegetables.
"Urbanites have stocked up on rice, lentil and oil to handle emergencies. But doing so on perishable vegetables and keeping those fresh for long is impossible. If villages are locked down one after another, the supply of vegetables to cities will stop," Ahsan Rony, president of non-profit organisation Green Savers, warned.
So far, the government has not suspended transportation of agricultural produces. Hence, a sizable amount of vegetables still arrive at some wholesale markets in Dhaka.
Are these vegetables safe? Rony thinks the virus can be transmitted through those too.
"During any contagion, hygiene must be maintained. Hence, people having access to build gardens on the rooftop or in the veranda can utilise the space to grow their own vegetables," he said.
"Growing vegetables on the rooftop and in the veranda is the only option for urban cultivation in Dhaka – the mega city that is covered, nearly 80 percent, by concrete."
Summer fruit Syzygium Malaccense or locally known "Jamrul" can be cultivated in rooftop garden as well. Photo: Sharier Khan
For good health
Consumption of vegetables is crucial for good health. Doctors say vegetables boost the body's immune system.
Besides ensuring nutrition, practicing home horticulture can also help people keep fit.
"People are getting bored by sitting idle at home. Gardening will be a remedy for those affected by lockdown. Going up and down the stairs as well as irrigation and weeding are good forms of physical exercise," said Dr MA Sobhan, a botanist and the president of non-profit BeezBistar Foundation.
For the last 20 years, Sobhan, former chief scientist at Bangladesh Jute Research Institute, has been maintaining a 2,200 sqft rooftop garden in Mirpur. "I am still physically fit at 79."
He cultivates all kinds of seasonal vegetables and fruits. Currently, he is producing string beans, cucumber, papaya, sweet gourd, bitter gourd and spinach.
According to Sobhan, most of the local varieties of vegetables can be cultivated on the rooftop. Plastic-made drums, buckets, trays or earthen pots can be used as containers.
"Regular cultivation is enough to meet the vegetable demand for three families," Sobhan said, adding that his married children's family members also consume the vegetables he grows.
Green Savers President Rony said there are approximately 20,000 small- and medium-scale rooftop gardens in Dhaka.
"On average, each building has a 1,500 sqft roof. Proper management of the space and an organised horticulture can ensure the daily vegetable demand of at least 10 families."
Urban horticulture requires hybrid varieties of seeds. Hence, it mostly depends on nursery. Fortunately, nurseries in Dhaka are still open and those interested can arrange the necessary stuff to start gardening.
In the time of total shutdown, family members are staying at home. This togetherness can be a source of inspiration for doing something good.
As Rony said, "The younger members can learn gardening by seeing the elders doing it. This will also inspire the new generation to love the green."
gardening / lockdown
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redpajama_set_name: RedPajamaCommonCrawl


A year or so ago, I bought Mima Sinclair's Rainbow Bakes Book and it's definitely one of my favourite baking books! It always inspires me to be a creative baker and I do love that you can make a special cake which looks amazing but isn't actually that complicated. Take this cake, for example. Underneath all the icing, it's actually a simple and tasty red velvet cake. The 'tricky' part is the icing and decorating. The icing itself is a simple buttercream icing, and the only 'tricky' thing with it is that the shape of the cake can be a bit awkward so you just have to be patient. As for the decorating – there is a little precision required and a lot of patience to be exerted as you make a rainbow from individual skittles. However, believe me, it's worth it for the fantastic result you get at the end! Full recipe below, but the original recipe and more fantastic bakes available in Mima Sinclair's Rainbow Bakes book.
3 large packets (or around 800g) of Skittles, or other rainbow coloured sweets, separated by colour.
First, make the cake. Preheat the oven to 180C/160C fan/gas mark 4. Grease a 20cm x 9cm bundt tin or ring mould. Using an electric hand whisk, beat the butter and caster sugar together in a medium bowl until light and fluffy. Add the eggs, one at a time, beating well after each addition. In a small bowl, combine the cocoa, food colouring paste and vanilla extract to make a thick paste. Whisk this into the butter mixture.
Beat in half the buttermilk until smooth and combined. Sift over the flour, bicarbonate of soda and salt and fold through evenly with a large spoon. Gently beat in the remaining buttermilk with vinegar, then beat the whole mixture for 2 minutes.
Pour into the prepared bundt tin, spreading evenly. Bake for 40 minutes, or until a skewer inserted into the centre comes out clean. Leave to cool in the tin for 10 minutes, then turn out onto a wire rack and leave to cool completely.
For the cream cheese icing, beat the butter and icing sugar together in a bowl until light and fluffy. Gradually beat in the cream cheese, a spoonful at a time, then beat in the vanilla extract until smooth and combined.
Ready to be iced and decorated!
To decorate, once the cake is cold, use a serrated knife to trim the top so that it's completely flat, then cut it in half vertically so you have to crescents. Use some of the cream cheese icing to sandwich the flat sides of the trimmed base together and then 'stand' them up on a serving plate or board securing them with a little icing underneath so the cake is the shape of a rainbow.
Using a palette knife, cover the outside of the cake evenly with the remaining icing, then press the Skittles or sweets in a coloured rows over the cake to look like a rainbow.
Original recipe from Mima Sinclair's book Rainbow Bakes.
Just a note to say, the cake isn't hard to make but the decoration can be a wee bit fussy. The shape isn't the easiest to ice evenly and placing the skittles is a job for the patient ones! It takes a bit of precision and a lot of patience. However, it's definitely worth it at the end as the cake looks absolutely beautiful and it's just as delicious!


text:
package org.elasticsearch.xpack.unsignedlong;

import org.apache.lucene.index.DocValues;
import org.apache.lucene.index.NumericDocValues;
import org.apache.lucene.index.SortedNumericDocValues;
import org.elasticsearch.index.fielddata.FieldData;
import org.elasticsearch.index.fielddata.LeafNumericFieldData;
import org.elasticsearch.index.fielddata.NumericDoubleValues;
import org.elasticsearch.index.fielddata.ScriptDocValues;
import org.elasticsearch.index.fielddata.SortedBinaryDocValues;
import org.elasticsearch.index.fielddata.SortedNumericDoubleValues;

import java.io.IOException;

import static org.elasticsearch.xpack.unsignedlong.UnsignedLongFieldMapper.sortableSignedLongToUnsigned;

public class UnsignedLongLeafFieldData implements LeafNumericFieldData {
    private final LeafNumericFieldData signedLongFD;

    UnsignedLongLeafFieldData(LeafNumericFieldData signedLongFD) {
        this.signedLongFD = signedLongFD;
    }

    @Override
    public SortedNumericDocValues getLongValues() {
        return signedLongFD.getLongValues();
    }

    @Override
    public SortedNumericDoubleValues getDoubleValues() {
        final SortedNumericDocValues values = signedLongFD.getLongValues();
        final NumericDocValues singleValues = DocValues.unwrapSingleton(values);
        if (singleValues != null) {
            return FieldData.singleton(new NumericDoubleValues() {
                @Override
                public boolean advanceExact(int doc) throws IOException {
                    return singleValues.advanceExact(doc);
                }

                @Override
                public double doubleValue() throws IOException {
                    return convertUnsignedLongToDouble(singleValues.longValue());
                }
            });
        } else {
            return new SortedNumericDoubleValues() {

                @Override
                public boolean advanceExact(int target) throws IOException {
                    return values.advanceExact(target);
                }

                @Override
                public double nextValue() throws IOException {
                    return convertUnsignedLongToDouble(values.nextValue());
                }

                @Override
                public int docValueCount() {
                    return values.docValueCount();
                }
            };
        }
    }

    @Override
    public ScriptDocValues<?> getScriptValues() {
        return new UnsignedLongScriptDocValues(getLongValues());
    }

    @Override
    public SortedBinaryDocValues getBytesValues() {
        return FieldData.toString(getDoubleValues());
    }

    @Override
    public long ramBytesUsed() {
        return signedLongFD.ramBytesUsed();
    }

    @Override
    public void close() {
        signedLongFD.close();
    }

    private static double convertUnsignedLongToDouble(long value) {
        if (value < 0L) {
            return sortableSignedLongToUnsigned(value); // add 2 ^ 63
        } else {
            // add 2 ^ 63 as a double to make sure there is no overflow and final result is positive
            return 0x1.0p63 + value;
        }
    }
}

redpajama_set_name: RedPajamaGithub


Unlimited Water Processing also provides coffee products and coffee equipment solutions. We have all the equipment necessary for you to have coffee service setup in your office. Unlimited Water provides maintenance of all equipment supplied.


text:
Q: List items and iterators: do either push back or iterators create copies of original data? Though I've a lot of experience as C Embedded Programmer, I'm actually not so skilled in C++. I'm implementing a parser in which ItemsToBeFound are pushed within a list.
It happens that some of these items (let's say master items) carry more information, so that some other items (slave items) need to refer to master items to retrieve those info. This link is done at population phase, without iterators.
This is the sequence of the actions:

*

*I save the pointer to the master item, and push it to the list

*I set specific pointer field pReferenceItem of the slave item so that it points to the master item

*Later, I start the iteration through the list

*I save parsed information to master item

*When it comes to process slave item, I try accessing master item's field. But it is unchanged!

*The pointer to master item during iteration is different from the original one, so the pointer contained in slave item points to the original (unchanged) data

Any suggestion about some special qualifiers I could use in order to force the iteration through the original data? Any obvious mistake in the way I issue lists and/or iterators?
Please note that I'm sure about what asserted in step #6 above, because I've watched pointers values using the debugger.
Here's the simplified code showing the described issue:
#include <list>
#include <iostream>

std::list<ItemToBeFound> myList;

class ItemToBeFound
{
private:
public:
    /* ... */
    int specialDataToBeRetreived;
    ItemToBeFound *pReferenceItem;
    /* ... */

    ItemToBeFound( ItemToBeFound *ref )
    {
        pReferenceItem = ref;
        specialDataToBeRetreived = 777;
    }

    bool isMaster( void )
    {
        return ( pReferenceItem == NULL );
    }
}

void PopulateList( void )
{
    ItemToBeFound *masterItem = new ItemToBeFound( NULL /* no refItem */ );
    myList.push_back( *masterItem );

    ItemToBeFound *slaveItem = new ItemToBeFound( masterItem );
    myList.push_back( *slaveItem );
}

int main( void )
{
    // ...
    PopulateList();
    // ...

    /* Let's iterate and do something */
    std::list<ItemToBeFound>::iterator it = myList.begin();
    while( it != itemsList.end() )
    {
        if( it->isMaster() )
        {
            it->specialDataToBeRetreived = 42; /* In the real program I get the value after a parsing activity */
        }
        else /* it is a slave item */
        {
            it->specialDataToBeRetreived = it->referenceItem->specialDataToBeRetreived;

            /* But it doesn't work! */
            std::cout << "Updated special value: " << it->specialDataToBeRetreived << std::endl;
        }

        it++;
    }

    // ...

    return 0;
}

In the "slave" branch of the conditional, during iteration, I expect the specialDataToBeRetreived I set in reference object, but I keep obtaining 777 (the example value I set in the constructor):
Updated special value: 777

And the reason why I get this value is that, as shown by the debugger, the reference item in iteration phase has an address different from the original one, pointed by the slave item.

The questions

*

*Why did this change occur?

*I was expecting that the pointer to my object was just copied to the list, like in many list implementation I've seen in my life. Does the push_back method of the std::list template perform a copy of the pointed object?

A: Iterators do not copy anything. In C terms, they behave almost like pointers within array.
However, you do copy elements here:
void PopulateList( void )
{
  ItemToBeFound *masterItem = new ItemToBeFound( NULL /* no refItem */ );
  myList.push_back( *masterItem ); //copy of masterItem pointee

  ItemToBeFound *slaveItem = new ItemToBeFound( masterItem ); //initialized with masterItem, which does not point to the object stored in the list!
  myList.push_back( *slaveItem ); //copy of slaveItem pointee, also stores masterItem, but not object from the list

//slaveItem is leaked here, masterItem is only kept via slaveItem copy in the list
}

If you initialize objects like this, your slave objects never store pointers to objects in the list, but rather to the objects created with new.

Let's go step by step through the code (I'll be a rubber debugger here):
ItemToBeFound *masterItem = new ItemToBeFound( NULL /* no refItem */ );

You allocate an object on the heap (they don't have names, but let's call it m1) and a pointer on the stack called masterItem, so derefenced masterItem is exactly m1.
  myList.push_back( *masterItem );

std::list::push_back() creates a copy of the argument given to it (I ignore move semantics - they are not used here). Notice what is the argument - dereferenced masterItem or m1 as we called it before.
The copy of the object m1 created by push_back will be called m2
So now we have the following (with a->b meaning a points to b):
masterItem->m1
myList->m2

Next line:
  ItemToBeFound *slaveItem = new ItemToBeFound( masterItem );

Here, you initialize slaveItem with new object on the heap - s1.
masterItem->m1
myList->m2
slaveItem->s1->masterItem->m1 (s1 points to masterItem, which points to m1)

Last one:
myList.push_back( *slaveItem );

Again, push_back() creates a copy of its argument on the heap (this copy will be called s2)
masterItem->m1
slaveItem->s1->masterItem->m1
myList->m2
myList->s2->masterItem->m1

Eventually, you have:

*

*4 objects on the heap: m1, m2, s1 and s2 (all of type ItemToBeFound)

*2 objects on the stack: masterItem and slaveItem (both of pointer type)

*one object in the global area: myList (can be treated as stack object here)

*m2 and s2 are stored in myList and can be iterated over

*Both s1 and s2 have pointers to m1

*No slave object points to m2
Later on, when you run mainFunction(), object m2 gets filled with data, but object s2 is trying to retrieve data from m1, which wasn't filled with any valueable data.

It's hard to propose any solution without more info. One I'd use if I couldn't reorganize class structure would be to use std::list<std::shared_ptr<ItemToBeFound>> instead, which will keep your pointers safe, and only store std::weak_ptr<ItemToBeFound> referenceItem in slave objects (to avoid any circular dependecies and declare ownership clearly).
You could have std::list<ItemToBeFound*> and manage memory manually, but that's against modern C++ spirit and should be used with great care - flow can take more branches in C++ than in C and it's more difficult to track all of them to delete everything.
You could technically store in slave objects pointers to objects stored in the list (or even iterators to those), but that feels like a weird solution. You don't control those objects and you don't own them, so you shouldn't keep pointers to those.

redpajama_set_name: RedPajamaStackExchange


Vaporetto Pro 85_Flexi is a powerful steam cleaner ideal for several different surfaces thanks to its range of accessories. The continuous refill system lets you add water at any time and the powerful high-pressure steam from the pressurised boiler makes it the perfect ally for deep cleaning.
Note: This hose on this appliance is not detachable. The Vaporetto Pro 95_Turbo Flexi has a detachable hose and can be used with Polti ironing accessories.
Vaporetto Pro 85_Flexi was designed in Italy and is also made there in the Polti factory in Como province. We believe this guarantees a quality product, with attention paid at every step.
The effective sanitising power of steam is confirmed by tests performed by an independent laboratory, which found that Vaporetto products can eliminate up to 99.99% of bacteria, fungi and mould.
Vaporetto Pro 85_Flexi has been awarded the prestigious British Allergy Foundation seal of approval for its effectiveness in eliminating dust mites.
The new brush designed by Polti guarantees optimal steam delivery and distribution on the entire surface of the cloth, for faster and even more effective cleaning.
WHICH FLOOR AM I CLEANING TODAY?
No matter what surfaces are in your home, with the new Vaporflexi brush you can steam clean them all: tiles, gres, parquet, marble... And with the accessory frame, even carpets and rugs.
The new Vaporflexi brush makes Vaporetto 85_Flexi more manageable and free to move all around, letting it reach and clean even the most narrow corners.
The continuous refill system lets you fill the tank that sends water to the boiler at any time, to keep cleaning with no interruptions.
The convenient storage case on the front of the Vaporetto holds the various included accessories, both keeping them tidy and making them easily available during cleaning.
To effectively clean tile grouting and remove the dirt that gets stuck in these tiny spaces, use the steam concentrator combined with the small coloured brushes. Choose a colour for each type of surface or a given room to ensure the best hygiene.
The steam concentrator can be used, with or without the small nylon brushes, to combine the abrasive power of bristles with the effectiveness of steam and eliminate even the most stubborn dirt.
A sockette is provided to collect the dirt that is dissolved during steam cleaning. Use with the small brush.
Ideal to remove caked dirt, the brush combines the abrasive power of the bristles with the power of steam for a deeper cleaning. It is also ideal on delicate surfaces and the red colour allows you to keep it separate for different rooms, such as the kitchen or bathroom.


text:
Republicans see political necessity in health care effort
Sen. Lindsey Graham, R-S.C., joined by, from left, Sen. John Barrasso, R-Wyo., Majority Whip John Cornyn, R-Texas, Sen. Bill Cassidy, R-La., Sen. John Thune, R-S.D., and Senate Majority Leader Mitch McConnell, R-Ky., speaks to reporters as he pushes a last-ditch ... more >
By ALAN FRAM - Associated Press - Thursday, September 21, 2017
WASHINGTON (AP) - It's divisive and difficult, but the Republican drive to erase the Obama health care overhaul has gotten a huge boost from one of Washington's perennial incentives: Political necessity.
In the two months since Senate Republicans lost their initial attempt to scuttle President Barack Obama's statute, there's fresh evidence GOP voters are adamant that the party achieve its long-promised goal of dismantling that law. This includes conservative firebrand Roy Moore forcing a GOP primary runoff against Sen. Luther Strange, R-Ala., who's backed by President Donald Trump, and lots of money, plus credible primary challenges facing Republican Sens. Jeff Flake of Arizona and Nevada's Dean Heller.
"Republicans campaigned on this so often that we have a responsibility to carry out what you said in the campaign. And that's as pretty much as much of a reason as the substance of the bill" to support it, Sen. Charles Grassley, R-Iowa, told Iowa reporters in a conference call Wednesday.
"That base is so insistent. You made this promise, stick to it, and you'll be penalized if you don't," said Bill Hoagland, a former top Senate GOP aide and health policy expert.
GOP Sens. Bill Cassidy of Louisiana and South Carolina's Lindsey Graham have spent weeks concocting and selling the party's new approach to scrapping Obama's law. They say their proposal, shifting money and decision-making from Washington to the states, nearly has the votes it would need in a showdown expected next week, a deadline that's focused the party on making a final run at the issue.
Graham and Cassidy would end Obama's requirement that most people buy health coverage and larger employers offer it to workers. It would let insurers charge higher premiums to seriously ill customers and cut Medicaid, the health insurance program for the poor, over time. Money from the law's Medicaid expansion and cost-reductions it provides lower-earning people would be folded into block grants dispersed to states -totaling $1.2 trillion over seven years - with few federal strings attached.
The new package has clear appeal to most Republicans. It would wed the party's oft-repeated goals of uprooting Obama's law and shipping more power and plenty of money back home.
"We have ONE LAST CHANCE to repeal and replace the most intrusive, overbearing health care law in the history of our country," Cassidy emailed supporters Wednesday.
Republicans commanding the Senate by a 52-48 margin must stage the vote before Sept. 30, when special protections expire that have shielded the measure from needing 60 votes to pass. Three GOP defections would sink the measure because of solid Democratic opposition.
So far, conservative Sen. Rand Paul, R-Ky., has said he'll oppose the bill because it doesn't abolish enough of Obama's 2010 law. Sen. Susan Collins, R-Maine, has cited concerns including the measure's Medicaid cuts and seems a likely no, while noncommittal senators include Lisa Murkowski of Alaska and Arizona's John McCain.
That's not good enough for many conservatives. In a fundraising email, tea party leader Jenny Beth Martin said some party moderates "have betrayed their promises and utterly failed to fully repeal Obamacare. This is not acceptable."
More agonizingly for Republicans, Trump is back on the Twitter warpath. He tweeted Wednesday that he hopes Republicans will "fulfill their promise to Repeal & Replace Obamacare" and took special aim at Paul, a rival for last year's GOP presidential nomination.
"Rand Paul is a friend of mine but he is such a negative force when it comes to fixing healthcare," Trump wrote.
Trump used the platform to repeatedly savage Senate Majority Leader Mitch McConnell, R-Ky., after the effort's July collapse. With nearly 39 million followers, plenty of Republicans would rather not be his next target.
"They're scared to death of a promise they may not keep to the Republican primary base," said Sen. Chris Murphy, D-Conn.
Some Republicans have juxtaposed the new bill with last week's unveiling by Sen. Bernie Sanders, I-Vt., of a measure embodying a liberal dream of government-run health insurance, a dramatic reshaping of the country's health care system. Graham says the contrast - "socialism versus federalism" - has helped him fire up conservatives.
"It was a marriage of a desire for the base not to quit fighting and a new proposal that makes us want to fight more," Graham said in an interview. "The timing, I couldn't have scripted this."
Taking it one step further, Sen. John Kennedy, R-La., said he plans to propose an amendment that would bar states from using their block grants to set up state-run insurance systems. Analysts from both parties say such a threat is implausible because the GOP bill wouldn't give states enough money to do that.
"I've heard the argument that it's impossible. So what's the harm in putting it in," Kennedy said to reporters.
Others discount the impact of using Sanders' bill to drum up support for the Republican legislation. Wavering senators are likelier to base their decision on their views of how the bill will affect home-state constituents and its reception from local GOP officials and voters.
AP reporter Scott McFetridge in Des Moines, Iowa, contributed.


Happy New Year from all of us at Midwest Pinball!
We hope that 2018 is a great year for everyone. For those considering a game for their home or business, we wanted to let you know that, even after the holiday rush, we still have fantastic games for sale.
In the last blog, we highlighted three games and one of them, Bally's Silverball Mania, was purchased. For this blog, we will highlight another set of three, fun-to-play games: Stern's Meteor, Gottlieb's Shaq Attaq, and Gottlieb's Rack-A-Ball.
Stern's Meteor pinball game was produced in conjunction with the movie Meteor by American International Pictures. The game came out as a promo for the movie which starred Sean Connery and Natalie Wood.
The game features three flippers, one pop bumper, two passive bumpers, two slingshots, three star rollovers, three 3-banks of drop targets, one spinning target and one standup target. Meteor also features one 6-bank of memory drop targets. These special drop targets are held in memory and restored prior to each player's next ball. The bank then increases the bonus multiplier and activates other features.
This fun-to-play game was designed by Steve Kirk. Artists Leslie Kaip and Jorge Obregon drew their inspiration for the backglass and flyer from one of the movie's advertising posters.
This 4-player game has been configured for free play.
Gottlieb's Shaq Attaq gives players a real feel for basketball by sending the ball, through the air, toward a moving basket. With this ramp jump challenge, players must shoot a ramp with proper timing to launch their pinballs and sink point-scoring baskets.
The player plays as Shaquille in Events includeing: the Tip-Off, HORSE, the Alley-Oop, the Shot Clock, and Shatter the Backboard.
Shaq Attack is a fun game of pinball, complete with a Shaq Attaq Multiball and Hidden Features. The game has five "Hidden Features," each of which is awarded after performing a certain feat in the game. An end-of-game bonus is given for the number of Hidden Features found; getting all five awards an extra one billion points.
This solid state game was designed by Jon Norris and features art by Constantino Mitchell and Jeanine Mitchell. The game has been configured for free play.
Gottlieb's Rack-a-Ball is a classic 1960's pinball machine. It features 4 pop bumpers, 2 slingshots, 3 standup targets, 5 ball play, 2 bells and a knocker for sound and five lanes at the top of the playfield. The game also features nice animation in the backbox – pool balls rack up in a window as the player completes the numbered targets on the playfield.
This game features the great, clean artwork of Roy Parker. As the game is played, the lighting behind the glass highlights different characters. The back glass depicts characters playing a game of pool.
Rack-a-Ball is replay game. Each game starts with five balls, but the players have an opportunity to earn free games throughout the game.
This is a one-player game suitable for all ages. The game has been configured for free play.


text:
Q: Authenticated requests with a rails api, backbone.js and devise I have a rails api setup using devise for auth and backbone.js for the front end. I am able to get users to sign up and sign in, but I am having trouble making subsequent requests to the api. I need to append an auth token and an email address to every request after the sign in order to make further requests but I am not sure how to do that.
The flow of my app is like so

*

*send get request to /sign_in to set csrf header using custom backbone.sync

*send post request to /sign_in with credentials and get auth token back

*send token and email with every subsequent request

Sending the token and email with every request is the issue I'm having. How can I append it to the request in backbone?
Should I just add it to the http header like I am doing with the csrf token?
Here is my set up so far.
Api Controller with filters
class ApiController < ApplicationController
  respond_to :json
  before_filter :authenticate_user_from_token!
  # This is Devise's authentication
  before_filter :authenticate_api_v1_user!

  private

  def authenticate_user_from_token!
    user_email = params[:email].presence
    user = user_email && User.find_by_email(user_email)

    if user && Devise.secure_compare(user.authentication_token, params[:token])
      sign_in user, store: false
    end
  end
end

Session Controller
module Api
  module V1
    class SessionsController < Devise::SessionsController

  skip_before_filter :authenticate_user!, only: :create
  after_action :set_csrf_header, only: [:new, :create, :destroy]

  def new
    render nothing: true
  end

  def create
    user = User.find_for_database_authentication(:email => params[:email])

    if user && user.valid_password?(params[:password])
      user.ensure_authentication_token  # make sure the user has a token generated
      render :json => { :user => user }, :status => :created
    else
      return invalid_login_attempt
    end
  end

  def destroy
    # expire auth token
    user = User.where(:authentication_token => params[:authentication_token]).first
    user.reset_authentication_token!
    render :json => { :message => ["Session deleted."] },  :success => true, :status => :ok
  end

  private

  def invalid_login_attempt
    warden.custom_failure!
    render :json => { :errors => ["Invalid email or password."] },  :success => false, :status => :unauthorized
  end

  def set_csrf_header
    response.headers['X-CSRF-Token'] = form_authenticity_token
  end

  def form_authenticity_token
    session[:_csrf_token] ||= SecureRandom.base64(32)
  end

end
end
end

Override backbone.sync in order to set csrf headers
require([
'backbone',
'router',
'app',
'jquery.mobile',
'google',
'models/session_model'
], function(Backbone, Router, AppView, JQMobile, google) {
    window.Droppin = window.Droppin || {};

// overide backbone.sync
Backbone._sync = Backbone.sync;

Backbone.sync = function(method, model, options) {
  if (!options.noCSRF) {
    var beforeSend = options.beforeSend;

    // Set X-CSRF-Token HTTP header
    options.beforeSend = function(xhr) {
      var token = Droppin.csrfToken;
      if (token) xhr.setRequestHeader('X-CSRF-Token', token);

      // this will include session information in the requests
      xhr.withCredentials = true;

      if (beforeSend) return beforeSend.apply(this, arguments);
    };
  }

  var complete = options.complete;
  options.complete = function(jqXHR, textStatus) {

     // If response includes CSRF token we need to remember it
     var token = jqXHR.getResponseHeader('X-CSRF-Token')
     if (token) Droppin.csrfToken = token;

     model.trigger('sync:end');
     if (complete) complete(jqXHR, textStatus);
  };

  // Serialize data, optionally using paramRoot
  if (options.data == null && model && (method === 'create' || method === 'update' || method === 'patch')) {
    options.contentType = 'application/json';
    data = JSON.stringify(options.attrs || model.toJSON(options));
    if (model.paramRoot) {
      data = {};
      data[model.paramRoot] = model.toJSON(options);
    } else {
      data = model.toJSON();
    }
    options.data = JSON.stringify(data);
  }

  return Backbone._sync(method, model, options);
};

Backbone.history.start();
new AppView();
new Router();
});

A: you can overwrite globally all the jquery ajax requests to include something in the header.


text:
Q: jquery select link by name i can reference link with specific id with following code
 $(document).ready(function(){
       $("a#example_link_id").click(function(event){
         var url = $(this).attr("href");
          get_uid(url);
         //event.preventDefault();

       });
  });

is it possible to use $("a#example_link_id") this by link name

A: you might be looking for this:
var $link = $("a[name=some_name]");

where some_name is the value of the name attribute of the link

A: Your selector(s) can include specific attributes as well. For example:
$("a[name='foo']");

Which would select
Foo

For more information, http://api.jquery.com/category/selectors/


text:
Scarlett Chidgey (Kinawataka Women Initiatives - KIWOI): Following an undergraduate degree in Journalism from Boston University, Scarlett worked as a communications manager for a science communications firm in Berkeley, CA. She then left to volunteer in Mongolia. Scarlett then served for five years as the Program and Communications Manager at the Alliance for International Women's Rights (AIWR), an organization that supports women leaders and future leaders in developing countries. Prior to graduate school, Scarlett ran her own business as a communications and web consultant, managing projects and developing websites. Scarlett graduated from University of Denver's Josef Korbel School of International Studies with an M.A. in International Studies and concentration on Gender, Human Rights, and Development. After her fellowship Scarlett wrote: "The [fellowship]… enriched my perspective by giving me solid experience and examples to further support my human rights and development philosophy. It also enhanced my understanding of how grassroots organizations can operate and the struggles they face."
A Training in Making Straw Products
Since Benedicta Nanyonga and Kinawataka Women Initiatives invented the plastic straw products a few years
Safari in Murchison Falls National Park
In northwest Uganda, about 300 kilometers and a five-hour drive away from Kampala, is Murchison
The Children of KIWOI
Uganda is a country about the size of Oregon, with a population of nearly 33
A Brief Tour of Kinawataka
At least five days a week (sometimes six), I leave my comfortable home at the
The Straw Story
One day about eight years ago, Executive Director Benedicta Nanyonga and some other women from
Kinawataka Straw Fashions Head to America
The day after I arrived in Kampala, Benedicta told me that she had been invited
I Have Arrived
The journey from Rome to Entebbe was long and I was exhausted after a series
The Adventure Is About to Begin
Since I was young, I have longed to travel to Africa. I imagined climbing Mount


text:
Udoka Azubuike
COVID-19 Updates: White, Green, McLaughlin, Roby, Azubuike
January 16th, 2022 at 1:48pm CST by Alex Kirschenbaum
Spurs guard Derrick White exited the NBA's COVID-19 health and safety protocols last night, per Jeff McDonald of the San Antonio Express-News (Twitter link). White suited up for San Antonio and logged 25 minutes off the bench in an eventual 101-94 victory over the Clippers on Saturday.
The 6'4″ combo guard out of Colorado shot 7-of-11 from the field and 2-of-4 from the free-throw line for a total of 19 points in the victory. He also chipped in four assists, four rebounds, a steal and three blocks. White is currently averaging 14.6 PPG, 5.4 APG and 3.5 RPG during his sixth NBA season with the 16-27 Spurs.
Here are more COVID-19 updates from around the NBA:
Nuggets reserve power forward JaMychal Green has entered the league's COVID-19 protocols, per Shams Charania of The Athletic (Twitter link). The 31-year-old veteran is averaging 5.7 PPG and 3.7 RPG across 35 contests with the Jazz during the 2021/22 NBA season.
Timberwolves reserve point guard Jordan McLaughlin has entered the league's coronavirus protocols and will be unavailable for Minnesota ahead of today's contest against the Warriors, according to Minnesota's PR team (Twitter link).
Thunder power forward Isaiah Roby has exited the NBA's health and safety protocols, according to Joe Mussatto of the Oklahoman (via Twitter). The 6'8″ big man was available to play in yesterday's 107-102 loss to the Cavaliers, though he was ultimately a DNP – CD.
Jazz center Udoka Azubuike has cleared the protocols, tweets Ryan Miller of KSL.com. The 22-year-old seven-footer has appeared sparingly for Utah thus far this season, suiting up for just six games.
Derrick White
Isaiah Roby
Northwest Notes: DSJ, Zeller, Nuggets, Beverley, Azubuike, Kalaitzakis
January 7th, 2022 at 2:24pm CST by Luke Adams
The Trail Blazers will keep Dennis Smith Jr. on their roster through the salary guarantee date, ensuring that he receives his full salary for 2021/22, sources tell Adrian Wojnarowski of ESPN (Twitter link).
Smith won a training camp battle to earn a regular season roster spot and has averaged 5.4 PPG and 3.3 APG in 19 games (17.2 MPG). While his shooting numbers (.396 FG%, .273 3PT%) are below his mediocre career rates, Smith has apparently made enough of an impress on the Trail Blazers to stick around as the team's 14th man. He'll earn a $1,789,256 salary ($1,669,178 cap hit) for the season.
Wojnarowski also provides another updates on the Trail Blazers, tweeting that center Cody Zeller is expected to be available vs. Cleveland on Friday night. Zeller, who hasn't played since December 6, missed time due to a knee injury and a stint in the health and safety protocols, but it appears he's been cleared to return on both fronts.
Here's more from around the Northwest:
Nuggets forwards Jeff Green and Zeke Nnaji are no longer in the health and safety protocols, but two-way rookie Petr Cornelie has entered them, tweets Mike Singer of The Denver Post. Because the team still has one player in the COVID-19 protocols, hardship signee Davon Reed can remain active.
The Patrick Beverley trade has been a major coup for the Timberwolves, according to Jim Souhan of The Star Tribune, who says the veteran guard has been an "ideal leader" for the young team. Minnesota gave up Jarrett Culver and Juan Hernangomez to land Beverley.
Udoka Azubuike hasn't played much for the Jazz since being selected with the 27th pick in the 2020 draft, but he logged a career-high 16 minutes in his first ever start on Wednesday in Denver, holding his own against Nikola Jokic. Tony Jones of The Athletic has the story on the young center's unexpected showcase, which came with Rudy Gobert and Hassan Whiteside unavailable. "I'm not going to lie to you, I was a little nervous," Azubuike said. "I just came back from (an ankle) injury, and I'm playing against the MVP? That was a lot to process."
Georgios Kalaitzakis, the 60th overall pick in the 2021 draft who was waived by Milwaukee earlier this season, has signed an NBA G League contract, as our JD Shaw recently reported (via Twitter). The 23-year-old Greek forward joined the Oklahoma City Blue and appeared in his first game with the Thunder's affiliate on Thursday.
Cody Zeller
Dennis Smith Jr.
Georgios Kalaitzakis
Petr Cornelie
Zeke Nnaji
Northwest Notes: Billups, Thunder, SGA, Azubuike
December 3rd, 2021 at 9:03am CST by Arthur Hill
Trail Blazers head coach Chauncey Billups was unhappy with his team's effort after Thursday's 31-point loss to the Spurs, writes Aaron Fentress of The Oregonian. It may have been the most frustrating defeat of the season for an 11-12 Portland team that is trying to gain traction in the Western Conference playoff race. The Blazers were missing star guard Damian Lillard, who is sidelined with an abdominal injury, and Nassir Little, who is nursing a sore ankle, but Billups doesn't see their absences as an excuse for the blowout.
"My biggest concern I think at the moment is, I want us to compete harder," he said. "I want us to compete in every game. And I don't feel like every game we do that. I really don't. I don't feel like we do that every night. And that concerns me."
Billups was particularly upset that his team didn't execute the game plan against San Antonio, allowing the league's worst three-point shooting team to hit 14-of-36 from beyond the arc. He also hinted that he will experiment with rotation changes based on competitive spirit.
"I'm willing to lose games that way," Billups said. "I've ended games with lineups that people probably scratched their head at. But if I find guys that's gonna compete, and have this winning spirit about them, I love it."
There's more from the Northwest Division:
The Thunder made some unwanted NBA history Thursday night with the most lopsided loss since the league was formed, notes Joe Mussatto of The Oklahoman. Oklahoma City coach Mark Daigneault said the 152-79 defeat against Memphis isn't an accurate way to judge his team, which was on the second night of a back-to-back and played without Shai Gilgeous-Alexander, Josh Giddey and several other players. "This isn't indicative of who our team is, how we've competed all season from training camp all the way through the games," Daigneault said. "It's important I think to keep that in mind internally for us."
Gilgeous-Alexander was placed in concussion protocol after being fouled twice on layups in the fourth quarter of Wednesday's game, Mussatto adds. He had a headache on the Thunder's flight to Memphis Wednesday night, then felt worse after waking up from a nap Thursday afternoon. Daigneault said he would have kept Gilgeous-Alexander at home if he realized he had suffered a concussion.
Jazz center Udoka Azubuike won't need surgery on the dislocated right ankle he suffered last week, according to Sarah Todd of The Deseret News. Sources tell Todd that Azubuike will begin rehabbing the ankle, but the process may take most of the season.
Chauncey Billups
Shai Gilgeous-Alexander
Jazz Center Udoka Azubuike Injures Ankle In G League Game
November 27th, 2021 at 4:27pm CST by Arthur Hill
Udoka Azubuike suffered a partially dislocated right ankle while playing for Utah's G League affiliate Friday night, the Jazz announced (via Twitter).
The team's medical staff determined that the second-year center has a subluxation in his right ankle, but initial X-rays didn't show a fracture. Doctors will continue to review the MRI results to set a timetable for Azubuike's recovery (Twitter link).
Azubuike was hurt in the first quarter of the Salt Lake City Stars' game when he landed awkwardly after attempting to block a shot, according to Kyle Ireland of KSL Sports. Teammates had to help him off the court and into the locker room.
The Jazz made Azubuike the 27th overall pick in 2020, but he hasn't seen much action at the NBA level. He played just 15 games as a rookie and has appeared in four so far this season, averaging 0.5 points and 1.0 rebounds in eight total minutes.
The 20-year-old also suffered a severe ankle sprain while playing in the G League bubble in February, Ireland notes. He didn't recover until after the abbreviated G League season has ended. In six games with the Stars this season, he's averaging 7.7 points, 11.0 rebounds and 1.7 blocks per night.
Jazz Notes: Gobert, Ingles, Mitchell, Whiteside, Butler, Wade
November 12th, 2021 at 11:45am CST by Luke Adams
Jazz center Rudy Gobert and Pacers center Myles Turner engaged in a skirmish during Thursday's game in Utah, briefly wrestling with one another after getting tangled up following a Gobert drive (video link).
As Andy Larsen of The Salt Lake Tribune details, the incident resulted in ejections for Gobert and Turner, as well as for Joe Ingles and Donovan Mitchell. Ingles was ejected for shoving referee Ed Malloy while trying to break up the fight; Mitchell was said to be "acting as an instigator and escalating the situation." It's unclear if any players will face suspensions as a result of the incident, but fines, at least, seem likely.
After the game, Mitchell and Gobert were focused more on the way the game was being officiated than concerns about forthcoming penalties. Gobert said referees are "allowing guys to do way too much s–t" this season and Mitchell agreed.
"It's really at a point now, especially tonight, where the referees are allowing things to get out of hand," Mitchell said, per Sarah Todd of The Deseret News. "Both teams, we're competitors and we'll play through contact and talk s–t and do whatever. But at some point it's continuing to build and you can sense that."
Here's more out of Utah:
Hassan Whiteside has been a great fit so far as the Jazz's second-string center, Todd writes for The Deseret News. According to Todd, the veteran big man – who has been accused in the past of looking to pad his own stats – has embraced the team-first philosophy in Utah. "It's so cool how close this team is, I haven't been on a team that's this close," Whiteside said. "A lot of people say, 'Hey we're close team, hey we do this together.' Nah. This is really like a close-knit group. It's great. I love it."
Rookie guard Jared Butler can expect to bounce back and forth between the NBA and the G League this season, as Todd outlines in a separate story for The Deseret News. The veteran-heavy Jazz won't be making it a top priority to develop their young prospects at the NBA level, so Butler, Udoka Azubuike, and Elijah Hughes could all see reps for the Salt Lake City Stars when they're not part of Utah's rotation, says general manager Justin Zanik.
Dwyane Wade's position as a part-owner of the Jazz hasn't diminished his Heat fandom, writes Ira Winderman of The South Florida Sun Sentinel. Wade said he still "loves" his old team and would be rooting for them to win a championship if the Jazz don't. "Miami, from a personal standpoint, I would love to see them win it all," he said. "But I also would love to see us win it all. So, for me, it's a win-win."
Elijah Hughes
Jared Butler
Northwest Notes: Whiteside, Azubuike, Olshey, Wolves
November 6th, 2021 at 9:04pm CST by Arthur Hill
Hassan Whiteside's time with the Heat was often stormy, but he doesn't hold any grudges against his former team, writes Anthony Chiang of The Miami Herald. Whiteside, who signed with the Jazz during the offseason, said he remains in contact with some of his ex-teammates.
"(Udonis Haslem), Bam (Adebayo), I still talk to them guys," Whiteside said. "I even talk to (coach Eric Spoelstra). I told him, 'Happy Father's Day.' I still talk to them guys. There are no hard feelings. We broke up. We were in a relationship and we broke up. I don't hate nobody."
Whiteside revived his career with Miami in 2014/15 after two years out of the league. He was the team's starting center for five seasons, although he sometimes clashed with Spoelstra about playing time and his role on the team. He was traded to Portland in 2019 and is on his third team since that deal. In Utah, Whiteside has reunited with former teammate Dwyane Wade, who is a part owner of the Jazz.
"It's a special feeling. Having D-Wade, seeing a familiar face like that," Whiteside said. "He was a part of me even wanting to come to the Jazz. I don't know what I would have been without D-Wade. D-Wade, I don't think he knows how much he means to me."
The Jazz picked up their third-year option last week on Udoka Azubuike, which shows they still have confidence in the first-round pick from 2020, per Sarah Todd of The Deseret News. General manager Justin Zanik admits Azubuike has been placed in a difficult situation. "Last year we drafted him, and four days later he shows up to camp and we're asking of him, one; you're not going to get any reps in the regular season because of the goals that we have as the veteran team, and two; nobody in college plays like us," Zanik said. "The only way you can learn that is reps, but last year he had a major injury. He only played in one game."
The "bully act" by Trail Blazers president of basketball operations Neil Olshey has been allowed to continue for too long, contends John Canzano of The Oregonian. The team has opened an investigation into Olshey amid accusations of a toxic work environment. Canzano states that Jody Allen deserves some of the blame for not controlling Olshey's behavior during the three years she has owned the team.
Jon Krawczynski of The Athletic examines the issues that have caused the Timberwolves to go into a four-game tailspin after a 3-1 start. Krawczynski notes that teams have discovered Minnesota doesn't have enough shooters to make them pay for doubling Karl-Anthony Towns, while Anthony Edwards and Jaden McDaniels have hit rough spots after strong rookie seasons.
Neil Olshey
Northwest Notes: Simons, Conley, Azubuike, Z. Wade
October 31st, 2021 at 1:57pm CST by Alex Kirschenbaum
Trail Blazers forward Anfernee Simons has really started to blossom during his fourth year, writes Jason Quick of The Athletic.
A lot of Simons' improvement appears to be a credit to his commitment to offseason workouts with longtime trainer Phil Beckner. One of Portland's many undersized guards, Simons is averaging career highs of 12.6 PPG, 3.0 RPG, 2.4 APG and 22.8 MPG through his first five games during the 2021/22 season.
"Usually, he would train with me here and there," Beckner said. "And at the start of the summer he wanted to know where I was going to be. I told him either Phoenix or Portland. So I asked him where he was going to be. His answer: 'Wherever you are at."'
"Everybody kept telling me, 'My time is coming. My time is coming …' and I wanted to be prepared," Simons said. "New coach, new opportunity, and I wanted to be prepared as much as possible to show I'm ready for it. So that was my whole thing this summer: follow Phil around and get better each day."
There's more out of the Northwest Division:
34-year-old veteran Jazz point guard Mike Conley sat out his first game of the season yesterday, a 107-99 loss to the Bulls in which the Jazz desperately could have used Conley's leadership, in a conscientious load management decision from head coach Quin Snyder. Eric Walden of the Salt Lake Tribune details Utah's thinking. "It's more of a holistic decision, and one that we think is the best for our team and for Mike," Snyder said. "I think, given the choice, he'd try to play every back-to-back. But I'm not gonna let him do that." Conley is set to return tonight against the Bucks, per Jazz.com.
Newly-installed Jazz general manager Justin Zanik addressed the decision to pick up the team's 2022/23 option on intriguing second-year center Udoka Azubuike, writes Eric Walden of the Salt Lake Tribune. "I was very happy with him in the summer and the work that he's done," Zanik said. "It's just really hard to be in game-type shape when you're not playing games." Azubuike appeared in just 15 contests as a rookie.
19-year-old rookie guard Zaire Wade, selected with the tenth pick in the NBA G League draft by the Salt Lake City Stars, G League affiliate to the Jazz, acknowledged grappling with detractors in his entrance to the pro ranks, writes Andy Larsen of the Salt Lake Tribune. His father, future Hall-of-Famer Dwyane Wade, is a part-owner of the Jazz. "I think a lot of people think that I'm not a hard-working kid and things get handed to me," Zaire said. "Nothing's handed to me. Coach said he noticed after the first day I stepped here, I'm just working hard trying to earn everything myself. I'm trying to make a name for myself."
Anfernee Simons
Justin Zanik
Phil Beckner
Zaire Wade
Jazz Exercise 2022/23 Option On Udoka Azubuike
October 29th, 2021 at 6:53pm CST by Rory Maher
The Jazz have picked up their 2022/23 third-year option on Udoka Azubuike, the team announced in a press release.
The Jazz selected Azubuike with their first-round pick (27th overall) in the 2020 draft. As a second-year former first round pick, his salary is fully guaranteed this season. Exercising the team option means his salary for next season will be guaranteed as well. Azuibuike will earn $2,174,880 in '22/23.
Azubuike, a hulking center with a massive 7'7″ wingspan, appeared in just 15 games as a rookie last season, averaging 1.1 points and 0.9 rebounds in 3.8 minutes per game.
He most recently saw action during 2021 Summer League, averaging 13.7 points, 10.7 rebounds and 2.7 blocks per game in three games in Salt Lake City, and 13.8 points, 8.8 boards and 2.5 blocks in four contests in Las Vegas.
Azubuike figures to see a lot of time in the G League this season, as the Jazz have three-time Defensive Player of the Year winner Rudy Gobert at starting center, with Hassan Whiteside as backup.
All decisions on rookie scale options for 2022/23 are due by Monday, Nov. 1. We're tracking them right here.
Western Notes: Azubuike, Jackson, Wright, Green
August 13th, 2021 at 9:59pm CST by Dana Gauruder
Jazz 2020 first-round selection, big man Udoka Azubuike, was hampered by a severe ankle sprain in his rookie campaign, Sarah Todd of the Deseret News writes. Azubuike suffered the injury during the Salt Lake City Stars' first game in the G League bubble last season. "It was tough, it was really tough for me going through that injury, that process," Azubuike said. "Not being out on the court practicing or learning, doing what a regular rookie like me would do." He'll likely compete for backup center minutes this season with veteran acquisition Hassan Whiteside.
We have more from the Western Conference:
The King's young players are not the only ones going through a learning process during summer league action. Bobby Jackson, the team's summer league coach, is also gaining valuable experience, Jason Jones of The Athletic writes. "I can get better in late-game situations, understanding who to have on the floor, the substitutions, all the stuff that comes with it," Jackson said. "But me and my stuff, just like the players have to do a better job, we've got to do a better job of making sure we have the right personnel on the floor. But it's a growing experience for me, I love it." Jackson was also recently named the head coach of the G League's Stockton Kings.
McKinley Wright IV received a two-way deal from the Timberwolves last week. The former Colorado standout grew up in Minnesota and is thrilled to play in his home state, according to Chris Hine of the Minneapolis Star Tribune. "I didn't know that I was going to be coming home," Wright said. "I didn't know that Minnesota was this interested in me. … I told my family, 'We didn't hear my name called how we initially planned, but this is better for me, going undrafted, betting on myself, and I continue to look forward to proving people wrong."
Jeff Green's versatile offensive game, which is built around 3-point shooting and elite finishing around the rim, should be a major boost for the Nuggets' second unit, Eric Spyropoulos of the team's website writes. The veteran big man signed a two-year deal with Denver in free agency.
Bobby Jackson
McKinley Wright
Jazz Rumors: Lindsey, Snyder, Azubuike, Wade, Ainge, Battier
Dennis Lindsey's transition from his executive VP of basketball operations position with the Jazz into an advisory role was framed as Lindsey's call, but it was more of an ownership decision, according to Andy Larsen and Eric Walden of The Salt Lake Tribune.
As Larsen and Walden explain in an in-depth story, new Jazz owner Ryan Smith is making some changes to the front office — director of pro player personnel David Fredman was also told this week that his contract isn't being renewed.
One factor in the decision to reassign Lindsey was a "long-running disconnect" between the executive and head coach Quin Snyder, per the Tribune's report. According to Larsen and Walden, Lindsey and Snyder had numerous disagreements both on and off the court, including not seeing eye to eye on rotation and roster decisions. Snyder – along with many members of the front office – were frustrated by the selection of Udoka Azubuike in the first round of the 2020 draft, per Larsen and Walden.
Given Utah's success during the 2020/21 season, Lindsey and Snyder were on better terms during the last year, but several people in the organization still felt that this week's announcement reflected a feud being settled. "Quin won," one source told The Tribune.
Here's more on the Jazz's front office shakeup:
While Lindsey is now an advisor in the Jazz's front office, there's an expectation that he'll seek a job with another team, according to Larsen and Walden.
Dwyane Wade has "added his voice" to front office discussions, but isn't taking a day-to-day role in basketball and roster decisions, per Larsen and Walden.
If former Celtics executive Danny Ainge joins the Jazz, it will likely be in an advisory role, says Tony Jones of The Athletic.
Jones, Larsen, and Walden all say more front office additions are expected. Multiple reporters, including Jones, ESPN's Brian Windhorst, and Barry Jackson of The Miami Herald suggest that Wade's former teammate Shane Battier is one candidate to join the basketball operations department. Battier worked in the Heat's front office from 2017-21, but recently left that position and is now just a consultant for Miami.
Dennis Lindsey
Shane Battier


Sharing the weight and speaking your thoughts can be energy releasing and transformative. I work to bring about positive change in people's lives – change in their emotional outlook, change in their relationships; both social and intimate - so they can move beyond blocks and dilemmas towards well-being and fulfilment.
As a fully qualified Counsellor and NLP Practitioner I provide a service which is designed in partnership with each client to ensure varying needs are met. Pace, style and frequency of sessions are considered and adapted to suit the unique circumstances to each person. I provide a professional and confidential service at all times. My experience also includes couples counselling for those wishing to work through issues together.
I have several years of experience in assisting people to gain insight into matters relating to psychological, sexual and financial abuse, work concerns, stress management, bereavement, relationship difficulties, low self-esteem, low mood and apprehensions. I practice in both short and long term therapy; and will negotiate the input needed with each individual according to your needs.
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Salem es la capital del estado estadounidense de Oregón y del condado de Marion. Está ubicada en el valle Willamette, a lo largo del río Willamette, que atraviesa la ciudad en dirección norte. El nombre de la ciudad deriva de la palabra hebrea "shalom", que significa "paz". Salem ha sido la capital de Oregón desde 1851, con la excepción de unos meses en 1855, cuando se trasladó a Corvallis. La población de Salem era de 154637 habitantes en 2010. La mayor fuente de empleo en Salem es la administración del Estado, pero también es un destacado centro de procesamiento de alimentos agrícolas.

Geografía
Salem se encuentra ubicada en las coordenadas .

Demografía
Según la Oficina del Censo, en 2000 los ingresos medios por hogar en la localidad eran de $38 881, y los ingresos medios por familia eran de $46 409. Los hombres tenían unos ingresos medios de $34 746 frente a los $26 789 de las mujeres. La renta per cápita en la localidad era de $19 141. Alrededor del 15.0 % de la población estaba por debajo del umbral de pobreza.

Ciudades hermanadas

Salem está hermanada con las siguientes ciudades:

  Gimhae, Gyeongsang del Sur, Corea del Sur.
  Ibarra, Imbabura, Ecuador.
  Kawagoe, Saitama, Japón.
  /   Simferópol
  Salem, Comunidad Valenciana, España.

Educación
El Distrito Escolar de Salem-Keizer gestiona las escuelas públicas de la ciudad.

Referencias

Enlaces externos

En inglés
 City of Salem Official Government Website, sitio oficial de la ciudad
 Salem Oregon Community Guide, sitio no comercial de la ciudad
 Salem Oregon History in Brief, una corta historia de Salem

En español
 Salem (Oregon) Historia en Línea, una corta historia de Salem

redpajama_set_name: RedPajamaWikipedia


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Les Assions est une commune française, située dans le département de l'Ardèche en région Auvergne-Rhône-Alpes.

La commune des Assions regroupe plusieurs hameaux de la région tels les Ravels, les Bourrels ou Champetier bas.

Les habitants sont appelés les Assionais et les Assionaises ; ils portent également le surnom de « Picourets ».

Géographie

Lieux-dits, hameaux et écarts
 le Bosc
 le Bourel
 Chadol
 Champetier (Haut et Bas)
 Peyreflore
 la Ribeyre
 Théraube

Communes limitrophes

Géologie et relief

Climat

Urbanisme

Typologie
Les Assions est une commune rurale. Elle fait en effet partie des communes peu ou très peu denses, au sens de la grille communale de densité de l'Insee.
Elle appartient à l'unité urbaine des Vans, une agglomération intra-départementale regroupant  et  en , dont elle est une commune de la banlieue.
La commune est en outre hors attraction des villes.

Occupation des sols

L'occupation des sols de la commune, telle qu'elle ressort de la base de données européenne d'occupation biophysique des sols Corine Land Cover (CLC), est marquée par l'importance des forêts et milieux semi-naturels (67,2 % en 2018), une proportion sensiblement équivalente à celle de 1990 (65,7 %). La répartition détaillée en 2018 est la suivante :
milieux à végétation arbustive et/ou herbacée (41,2 %), forêts (26 %), zones agricoles hétérogènes (19,5 %), zones urbanisées (10,6 %), cultures permanentes (2,7 %).

L'IGN met par ailleurs à disposition un outil en ligne permettant de comparer l'évolution dans le temps de l'occupation des sols de la commune (ou de territoires à des échelles différentes). Plusieurs époques sont accessibles sous forme de cartes ou photos aériennes : la carte de Cassini (), la carte d'état-major (1820-1866) et la période actuelle (1950 à aujourd'hui).

Histoire

Politique et administration

Tendances politiques et résultats

Administration municipale

Liste des maires

Population et société

Démographie

Évolution démographique

Pyramide des âges
La population de la commune est relativement âgée.
En 2018, le taux de personnes d'un âge inférieur à  s'élève à 25 %, soit en dessous de la moyenne départementale (30,3 %). À l'inverse, le taux de personnes d'âge supérieur à  est de 39,5 % la même année, alors qu'il est de 31,8 % au niveau départemental.

En 2018, la commune comptait  pour , soit un taux de 51,6 % de femmes, légèrement supérieur au taux départemental (51,19 %).

Les pyramides des âges de la commune et du département s'établissent comme suit.

Culture locale et patrimoine

Lieux et monuments
 Chapelle Sainte-Apollonie  au sommet du Puech.
 Église Saint-Apollinaire, reconstruite aux  sur une église romane détruite.
 Village abandonné du Cornilhon.
 Les capitelles du plateau des Gras.

Personnalités liées à la commune

 Jules Froment, prêtre et poète, a grandi aux Assions.

Annexes

Articles connexes
 Liste des communes de l'Ardèche
 Plateau des Gras

Liens externes

 Les Assions sur le site de l'Institut géographique national (archive)

Notes et références

Notes

Références

Commune en Ardèche
Commune dans l'arrondissement de Largentière
Commune membre du parc naturel régional des Monts d'Ardèche
Unité urbaine des Vans


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@Component({
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})
export class SidenavComponent {
}


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Vigário Geral és un barri de la Zona de la Leopoldina, en la Zona Nord del municipi de Rio de Janeiro, en l'estat de Rio de Janeiro, al Brasil. Limita amb els barris de Jardim América, Irajá i Parada de Lucas, i amb el municipi de Duque de Caxias. El seu índex de desenvolupament humà, l'any 2000, era de 0,763, el 107 entre 126 regions analitzades en el municipi de Rio. És un dels barris més antics de la Zona de la Leopoldina.

Història

El barri de Vigário Geral va tenir origen quan la implantació de la línia de tren. Conta la història que el Vicari general de la freguesia d'Irajá anava en tren des del Centre de la ciutat fins a l'estació del Velho Engenho (actual Vigário Geral) i, des d'allà, seguia a cavall fins a la seu, que se situava en l'església construïda en la primera meitat del  i que es localitza actualment al costat del cementiri d'Irajá. El camí que recorria es coneixia com a Estrada do Vigário Geral, la qual tallava el barri. Amb el temps, la carretera va acabar per donar el seu nom al barri. L'Avinguda Brasil, quan es va construir la dècada de 1940, va tallar l'Estrada do Vigário Geral.

Les primeres construccions en el barri es van fer a finals de la dècada de 1930 a través de la Companhia Territorial do Rio de Janeiro. A final de la dècada de 1940, el barri va cedir el seu nom a la favela que s'aixeca en el terreny al costat de la línia fèrria de la Leopoldina.

El 1950, una part de l'antiga Hisenda Botafogo, adjacent al barri, va ser urbanitzada, creant-se l'antic sub-barri i actual barri anomenat Jardim América.

El 1966, el Conjunto Habitacional Pare José de Anchieta, finançat per l'extint Banco Nacional da Habitação, va ser inaugurat amb la presència del llavors president de la república, el general Humberto d'Alencar Castelo Branco. Posteriorment, ja en la dècada de 1970, va ser inaugurat el Conjunto Habitacional Vigário Geral.

Aquella època, el barri, eminentment residencial, va tenir diverses industries instal·lades, com la Paskin Cia. Ltda. i la Freitas Leitão Ind. i Com., les quals, per pressió de les associacions de veïns, van ser, per fi, tancades a causa de la contaminació que causaven.

Actualment, Vigário Geral es un pol de comerç de productes importats de la Xina, com vaixelles, plàstics, vidre i material escolar al detall i a l'engròs.

Referències

Bibliografia

Barris de la zona nord de Rio de Janeiro


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10 nov 2020 mk2 films boards sales on Mounia Akl's COSTA BRAVA LEBANON
Paris-based mk2 films have boarded sales on Lebanese director Mounia Akl's dark comedy COSTA BRAVA LEBANON about a family whose seemingly idyllic lifestyle in the mountains is threatened by the construction of a landfill site on their doorstep.
The production has recently signed Lebanese filmmaker and actress Nadine Labaki (Capernaum, Where Do We Go From Here?) to co-star opposite Palestinian actor Saleh Bakri, who is best known internationally for his performances in The Band's Visit and Wajib.
The pair play a couple who remove their family from the toxic pollution and rubbish-strewn streets of their home city of Beirut and attempt to build a utopian existence in a pristine home in the mountains.
This dream life is shattered when a landfill is built right outside its fence, bringing the garbage and corruption they hoped to leave behind to its door. As the trash rises, so do the tensions in their perfect home.
COSTA BRAVA LEBANON is the debut feature of Akl, a Screen Arab Star of Tomorrow in 2016, who originally broke out internationally with her short film Submarine in 2015 and then picked up credits on the Jude Law-produced series Do Not Disturb.
CHARLES CHAPLIN'S A WOMAN OF PARIS IN OFFICIAL SELECTION AT BERLINALE CLASSICS
mk2 films is proud to announce that A WOMAN OF PARIS by Charles Chaplin is premiering...
3 FILMS SHORTLISTED AT THE OSCARS 2023
We are delighted to announce that 3 of our films have been shortlisted at the Oscars 2023: CORSAGE by Marie KREUTZER for International...
THE POD GENERATION WILL PREMIERE AT SUNDANCE 2023
THE POD GENERATION by Sophie Barthes is heading to Sundance in the Premieres section of the 2023 edition! Starring...
MK2 FILMS BOARDS IRISH COMEDY 'FOUR MOTHERS'
Paris-based mk2 films will be launching sales on Four Mothers at this year's American Film Market. Directed by...


text:
Home » TERMINAL PACÍFICO SUR VALPARAÍSO GOES LIVE WITH N4 TERMINAL OPERATING SYSTEM
TERMINAL PACÍFICO SUR VALPARAÍSO GOES LIVE WITH N4 TERMINAL OPERATING SYSTEM
Navis, a part of Cargotec Corporation, and provider of operational technologies and services that unlock greater performance and efficiency for the world's leading terminal operators, today announced that Terminal Pacffíco Sur Valparaíso (TPSV), part of the Ultramar Group, has successfully gone live with the Navis N4 terminal operating system (TOS). Upgrading to N4 from a legacy, in-house TOS will help the terminal achieve key operational goals, such as improving the safety of yard workers and increasing terminal productivity by managing resources in a more efficient way.
Terminal Pacffíco Sur Valparaíso, located on the south pacific coast of Chile, is a major container terminal in Chile and Latin America, and is one of the most efficient terminals in the region. TPSV operates in an area of over 14 hectares composed of five berths, handling an average of 1,000,000 TEUs. Nearly 90 percent of cargo coming through Valparaíso is processed through TPSV which amounts to over 10.3 million tons per year.
"The implementation of Navis N4 TOS has been a major milestone for our terminal in the last year," said TPSV Operations Manager Gabriel Tumani. "With the goal of expanding our throughput capacity, we looked for best-in-class technologies that would enable us to use our yard as efficiently as possible. We found that Navis offers the latest technology with proven results at more than 130 maritime terminals worldwide," continued Tumani. "I can happily say that the transition to N4 was the best move for us because not only has it allowed us to optimize the productivity of our equipment and people, but it has also made our shipyard safer for our employees."
Optimization of the operation was key to TPSV and by utilizing Prime Route via a global pooling concept of terminal tractors following the N4 go-live; TPSV has been able to reduce the average terminal tractors from 5.5 to 4.5 per gang. TPSV is anticipating 15% growth over the next five years and is looking forward to the flexibility of N4 helping them to manage that growth.
"N4 is continuing to gain market share and is becoming the de-facto TOS industry standard amongst terminals in Latin America, and via the first go-live in Chile and joint partnership with TPSV validates Navis as the most trusted TOS provider for some of Latin America's most strategic ports," said Chuck Schneider, Regional General Manager for Navis. "We share TPSV's goal of maintaining a very high standard of terminal productivity through maximizing terminal efficiency, and are proud to be working together to go above and beyond those high standards."
More Info: http://navis.com/news/press/terminal-pacifico-sur-valparaíso-goes-live-n4-terminal-operating-system
BASRA GATEWAY TERMINAL GOES LIVE WITH N4 TERMINAL OPERATING SYSTEM
BALTIC CONTAINER TERMINAL GOES LIVE WITH N4 TERMINAL OPERATING SYSTEM
Termont Goes Live with N4 Terminal Operating System


The University of Waterloo today announced that global life science company, PerkinElmer, has relocated its Canadian demonstration lab to Velocity Garage.
The move will give startups, entrepreneurs, and scientists in the incubator early access to PerkinElmer's life science lab instruments and software, as well as experts. The relocation is set to be completed sometime in April and will also give the US-based company a place to host customers and demo products.
"Access to scientific instruments and solutions for startups is often difficult because early-stage companies don't yet have the capital to purchase them," said Adrien Côté, Velocity's science lead and business advisor.
Côté, who also supports and advises many of Velocity's deep tech and deep science companies, noted that entrepreneurs will now be able to use those technologies to help accelerate products and with business development.
The Velocity incubator is home to a number of deep tech companies that often work, and rely on, sciences surrounding biology, chemistry, or physics. The University of Waterloo stated that this partnership will not only provide early access to the instruments needed for these projects, but also help it become more attractive to future or potential clients.
"Putting our Canadian customer lab into a leading incubator like Velocity is a natural fit. We look forward to bringing our passion for science to the community there, and to connecting with Velocity entrepreneurs as they help shape the future of work and life," said Tim Freeman, Canadian regional sales manager of PerkinElmer.
"PerkinElmer is all about innovating to create a better world, be that in maternal and infant health, rare disease study, pharmaceutical advancement, food safety and quality, or environmental testing and more," he noted.
This is PerkinElmer's second move into the Waterloo region community. In 2016, the company launched its software innovation lab in Kitchener's Communitech Hub. The LeanLab, as it is called, was the company's first innovation lab outside of its hometown, Cambridge, Mass.
Jay Shah, director of Velocity, noted that this new partnership will expand "the breadth and depth" of the product development capabilities of Velocity's startups.
"The use and popularity of our existing product development labs, testing, and fabrication equipment at Velocity is already nothing short of astounding in terms of what it allows early-stage startups to accomplish," Shah stated, noting, however, that Velocity's entrepreneurs will have greater leverage with state-of-art PerkinElmer tools to help build high-impact, globally competitive products, and companies.


Dawlish is a fascinating Regency resort town nestled attractively between steep surrounding hills. The railway sweeps along the entire seafront and beach. Character cottages, impressive villas, narrow streets, bustling shops, famous Black Swans and welcoming tea rooms is just a taste of what Dawlish has to offer.
A range of excellent facilities whatever your needs including schooling, shopping, leisure facilities and transportation links to nearby Exeter and Newton Abbot. Dawlish Warren is one of South Devon's favourite holiday destinations offering an award winning beach and 500 acre Nature Reserve which includes the Exe Estuary. Dawlish is the perfect place to work, live or visit.
The Manor House is used for Council Meetings, the Town Clerk's Office, and generally as a community building with rooms available for hire for weddings, functions and activities. The people of Dawlish and visitors are still free to walk and sit in the Manor grounds.


The first case of Ebola Virus Disease (Ebola) diagnosed in the United States was reported to CDC by Dallas County Health and Human Services on September 28, 2014, and laboratory-confirmed by CDC and the Texas Laboratory Response Network (LRN) laboratory on September 30. The patient departed Monrovia, Liberia, on September 19, and arrived in Dallas, Texas, on September 20. The patient was asymptomatic during travel and upon his arrival in the United States; he fell ill on September 24 and sought medical care at Texas Health Presbyterian Hospital of Dallas on September 26. He was treated and released. On September 28, he returned to the same hospital, and was admitted for treatment.
(3) immediately notify the local/state health department.
Please disseminate this information to infectious disease specialists, intensive care physicians, primary care physicians, and infection control specialists, as well as to emergency departments, urgent care centers, and microbiology laboratories.?


text:
Davis wins again in Vegas hot rod event
Posted by Dave Maxwell | Apr 4, 2015 | News, Sports, Top Stories | 0
Lincoln County Deputy Sheriff Captain Gary Davis won again in his Sheriff's style drag racer.
For the second year in a row, Davis said he recently won his class at the National Hot Rod Association sanctioned Las Vegas Shootout race at the Las Vegas Motor Speedway. He said over the three days of the competition, they had time trials, and the final eliminations. This is the eighth annual, he said, "and we have won three of the eight, the last two back to back."
Also involved was an appearance at the Sunrise Children's Hospital. The drag racer, a specially rebuilt and modified black and white Ford S-10 pickup truck, has all the markings of a Lincoln County Sheriff's vehicle, including the flashing red and blue lights on the top. Davis said he gets many comments just on how the vehicle looks. "It's pretty popular."
And it is also fast, covering the quarter-mile track in 8.97 seconds, at 153 miles per hour. The car's best time has been 8.92. "In racing," he said, "hundredths of a second can make all the difference."
The Davis family owns the car and all the family is the pit crew, he said. "The County just allows us to put their markings on it, along with some other logos from some of our sponsors."
Davis occasionally takes the vehicle around to the various schools in the county and shows the kids. It used to be painted green and white, "but when the department went to black and white last year," he said, "we changed the colors."
This week, Davis took the car to the Legacy Ranch at Hiko to show the students there. He also answered questions and told them of his own background and involvement in racing. He fired up the engine and at one point, even laid some rubber on a flat cement surface, just to show what it looks like as a drag racer gets ready to launch at the start.
The boys at Legacy ranch were the most interested at first, but when Davis said it has been shown that girl's reaction times are faster than men's, "then the girls started to take a closer interest."
A couple of years ago, Davis was featured on the popular BBC-TV program Top Gear, and blew away the British challenger.
The group to which Davis, and several other racers in Southern Nevada belong is called Nevada Heat, Racing to Educate Sponsors. His sponsor list includes NYE Community Coalition, Windmill Ridge, A Cowboy's Dream, Fischer Auto Body, Thomas Petroleum, VP Racing Fuel, Cannon Ranch, M.M. Heizer, Goff Motorsports, Bruce Haddrill, Narconon, Richard Haddrill, Davis Racing, American Shooters, Shelby Enterprises Inc., Goodyear Racing, Royal Purple Racing Oil, and Silver State Classic Challenge.
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