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South Shore voters get to polls ahead of Super Tuesday
Joe DiFazio The Patriot Ledger jldifazio
Between a selfie booth, extended hours and dozens of signs advertising early voting, town clerks are doing what they can to draw voters to the polls.
QUINCY — Doug Anderson headed to Quincy City Hall just after 10 a.m. on Tuesday to cast his vote, one week before the state's presidential primary. It was a mild day weather wise, and next week he said it looked like he had a lot on his plate.
"Next Tuesday looked like a busy day so I wanted to get it out of the way," Anderson said.
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Anderson was one of hundreds of voters on the South Shore who have already taken advantage of a week of early voting, the first time Massachusetts has had the option in a presidential primary. Most municipalities offer the chance to vote at town or city halls during business hours through Friday.
Massachusetts offered early voting ahead of the 2016 and 2018 November general elections, but the state is in new territory this week with five days designated for ballot-casting before the March 3 presidential primary.
In 2016, the last presidential cycle, about 1 million voters cast ballots statewide during a two-week early voting period before the general election — about one-third of all votes cast. Another two-week stretch ahead of the 2018 general midterm election attracted about 600,000 early voters, according to Massachusetts Secretary of State William Galvin.
On Monday, 323 voters cast ballots in Quincy, 267 did in Weymouth and 358 people voted in Braintree.
"I'm very excited," Quincy Town Clerk Nicole Crispo said. "We're happy to do it for the convenience of it for residents."
Voters can participate in Democratic, Republican, Libertarian or Green-Rainbow party primaries, depending on their registration. Un-enrolled voters can choose which party's primary to participate in when they go to vote.
Anderson, of Quincy, chose to cast a vote for Democrat Pete Buttigieg, the former mayor of South Bend, Indiana, in the basement of city hall.
Anderson said he liked Buttigieg's "whole presentation, whole demeanor," and appreciated that he was a gay man.
For Jan Thayer and George Hague who voted in Quincy City Hall on Tuesday where early voting signs are posted on the building and lawn, President Donald Trump was their choice.
"He saved America," Thayer said. "I don't like the things he says sometimes, but I don't have to hang out with him. I'm voting for the country, not the candidate."
Thayer said that voting early was "awesome," and that she appreciated there were no lines.
Trump is facing former Massachusetts Gov. Bill Weld and perennial candidate Roque "Rocky" De La Fuente in the Republican primary. Former Illinois congressman Joe Walsh, who is still on the Republican ballot, dropped out earlier this month.
In Weymouth, Donna Pizzi, was walking toward town hall just before 11 a.m. to cast her vote on Tuesday.
"My mother always said to do things before noon so there is no line," Pizzi said. "It's a few days early in this case."
Pizzi was one of a handful of voters streaming in and out of town hall to vote. She said she was voting for former Vice President Joe Biden, a Democrat.
"He's experienced and had put a lot of years in," Pizzi said. "He would be the best for international relations, an issue that's important to me . . . I don't want to hear someone scream at me for another four years whether it's Trump or Bernie."
Biden, Buttigieg and U.S. Sen. Bernie Sanders of Vermont will appear on a packed Democrat ticket that includes U.S. Sen. Elizabeth Warren of Massachusetts, U.S. Sen. Amy Kloubachar` of Minnesota, former New York City Mayor Michael Bloomberg, U.S. Rep. Tulsi Gabbard of Hawaii and billionaire Tom Steyer. The ballot will also have a number of candidates who have suspended their presidential campaigns, including former Massachusetts Gov. Deval Patrick.
Outside of Braintree Town Hall were four flags advertising early voting. Inside, Cahill Auditorium was transformed into a polling place with 48 voting stations, eight of which were handicap accessible, decorated in red, white and blue with "I voted" stickers available at the end for residents.
Braintree Town Clerk Jim Casey said his voting process is aimed at efficiency, said early voting this year will cost the town about $8,300 in labor, processing and other expenses.
"In my opinion, I wouldn't have it," Casey said. "I'm an old-timer. I like it on one day, which makes it feel like Christmas . . . but it's more convenient to my voters."
Casey said the last two times the state has had early voting, it hasn't increased turnout in his town.
Whitman Town Clerk Dawn Varley, who had 132 voters on Monday, also said that early voting hasn't appeared to boost turnout, but is trying something new this year to try and make voting more fun: a selfie booth.
"I try to do some fun and positive things," said Varley. "People get a kick out of it."
Trevette Campbell, of Weymouth, said that she liked voting early because she works at night. She said she was still weighing her options of who to vote for as she walked into town hall.
Weymouth Town Clerk Kathleen Deree was answering a phone call from a resident about early voting just after 11 a.m. She said that voting has been steady and that residents seemed very interested in the option. She said in 2016 that 9,000 out of almost 38,000 residents voted early in the presidential election in November, over a period of 11 days — more than twice the time allotted for early primary voting.
While voters making their ways to the polls early enjoy it, there are some down sides. Deree said some grants were available to help pay poll workers for the extra hours and early voting in the 2016 presidential election, but not for the primary this year.
"A little money would help. Anything would help," Deree said. "It's an unfunded mandate."
Material from State House News Service was used in this report. Reporter Joe Difazio can be reached at Jdifazio@patriotledger.com.


Two leaders in the CCTV, video analytics, biometrics and access control world have formalised their partnership.
Tensor plc has signed an agreement to become EyeLynx Limited's second official channel partner, under which EyeLynx has completed a bi-directional integration of Tensor's security and access control solutions into its iconic SharpView video recording and management software.
They formally unveiled their partnership at the Security & Counter Terror Expo (SCTX), where EyeLynx parent the Zaun Group, a PSSA member, and partners were exhibiting at SCTX for two days.
Tensor engineers have been trained to operate the SharpView system and give training to the end user. A further partner agreement is planned with Tensor Indonesia.


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CRAIG LANCASTER | Novelist. Essayist. Traveler in the World.
CRAIG LANCASTER | Home
Craig's Published Work
600 HOURS OF EDWARD
Craig's debut novel was originally published in 2009 by Riverbend Publishing of Helena, Montana. It was a Montana Honor Book and the 2010 High Plains Book Award winner for Best First Book. In 2012, a new edition was released by Lake Union Publishing of Seattle, and the book has gone on to be an international bestseller, with a translation in German.
Synopsis: A thirty-nine-year-old with Asperger's syndrome and obsessive-compulsive disorder, Edward Stanton lives alone on a rigid schedule in the Montana town where he grew up. His carefully constructed routine includes tracking his most common waking time (7:38 a.m.), refusing to start his therapy sessions even a minute before the appointed hour (10:00 a.m.), and watching one episode of the 1960s cop show Dragnet each night (10:00 p.m.).
But when a single mother and her nine-year-old son move in across the street, Edward's timetable comes undone. Over the course of a momentous 600 hours, he opens up to his new neighbors and confronts old grievances with his estranged parents. Exposed to both the joys and heartaches of friendship, Edward must ultimately decide whether to embrace the world outside his door or retreat to his solitary ways.
Heartfelt and hilarious, this moving novel will appeal to fans of Daniel Keyes's classic Flowers for Algernon and to any reader who loves an underdog.
Formats: Paperback, Kindle, audiobook
Click here to download a media kit, including book club questions
THE SUMMER SON
Craig's second novel was originally released in January 2011 by Lake Union Publishing. It was a fiction finalist in the Utah Book Awards. In 2017, Craig regained the publication rights and released a new edition of the novel under his own literary imprint, Missouri Breaks Press.
Synopsis: Mitch Quillen's marriage and career are failing, and his relationship with his father has been a disaster for decades. Approaching forty, Mitch doesn't want to become a middle-aged statistic. When his estranged father, Jim, suddenly calls, Mitch's wife urges him to respond. Mitch heads to Montana and a confrontation that will alter the course of his life. Amid a backdrop of rugged peaks and valleys, the story unfolds: violence that triggered the rift, thirty years of miscommunication, and the possibility of misplaced blame.
In The Summer Son, award-winning author Craig Lancaster delivers a powerful novel that invites readers into a family where conflict and secrets prevail, and where hope for healing and redemption abides.
Formats: Hardcover, paperback, Kindle, audiobook
THE ART OF DEPARTURE
Originally published in 2011 as Quantum Physics and the Art of Departure, Craig's collection of short stories was a High Plains Book Award finalist and a gold medal winner in the 2012 Independent Publisher Book Awards. In 2016, Craig released a new edition of the collection through Missouri Breaks Press, titling it The Art of Departure and including new short fiction.
Synopsis: A basketball coach gets caught between his team, his family, and the expectations of a town with a thirst for winning. A traveling salesman, stranded far from home, explores the dark corners of his life on a late-night bus ride. A prison inmate clings to his dignity and self-righteousness in a place where everything else is stripped away. A teenage runaway finds unexpected shelter. Mismatched lovers flail away from each other.
Craig Lancaster's debut collection of short fiction, originally released in 2011 to enthusiastic reviews, mined his home terrain of Montana and took on the notion of separation—from comfort, from ideas, from people, from security. Now updated with two new short stories and a selection of even shorter fiction, as well as a foreword from author David Abrams, this collection goes deep into farms, cities and suburbs, into love and despair, into what motivates us and what scares us, peeling back the layers of our humanity with every page.
Formats: Paperback, e-book*
*—e-book versions (MOBI, EPUB, PDF) can be downloaded for free by signing up for Craig's mailing list at the bottom of this page
EDWARD ADRIFT
The long-awaited follow-up to 600 Hours of Edward was published by Lake Union Publishing in 2013. It has been translated into German and Norwegian editions.
Synopsis: It's been a year of upheaval for Edward Stanton, a forty-two-year-old with Asperger's syndrome. He's lost his job. His trusted therapist has retired. His best friends have moved away. And even his nightly ritual of watching Dragnet reruns has been disrupted. All of this change has left Edward, who lives his life on a rigid schedule, completely flummoxed.
But when his friend Donna calls with news that her son Kyle is in trouble, Edward leaves his comfort zone in Billings, Montana, and drives to visit them in Boise, where he discovers Kyle has morphed from a sweet kid into a sullen adolescent. Inspired by dreams of the past, Edward goes against his routine and decides to drive to a small town in Colorado where he once spent a summer with his father—bringing Kyle along as his road trip companion. The two argue about football and music along the way, and amid their misadventures, they meet an eccentric motel owner who just might be the love of Edward's sheltered life—if only he can let her.
Endearing and laugh-out-loud funny, Edward Adrift is author Craig Lancaster's sequel to 600 Hours of Edward.
THE FALLOW SEASON OF HUGO HUNTER
Released in 2014 by Lake Union Publishing, The Fallow Season of Hugo Hunter was a Kindle First selection and has drawn praise for its gritty portrayal of the relationship between a boxer and the sportswriter who has covered him for his entire career.
Synopsis: From the bestselling author of 600 Hours of Edward comes the story of two small-town characters whose fates are inextricably linked.
Hugo Hunter, a would-be boxing champion, is thirty-seven, soft around the middle, and broke—his glory days long gone. Raised by his beloved grandmother, he is rough around the edges but has a kind heart. Watching Hugo ringside for nearly twenty years, sportswriter Mark Westerly has struggled to keep a professional distance while he's served alternately as Hugo's friend, mentor, and conscience. As Hugo lands on the ropes again, Mark steps in to try to save him and, along the way, gets an unexpected second chance of his own when he meets the gentle and lovely Lainie.
In this moving tale of human folly and kindness, can two people who've lived so long under the weight of their pasts finally find redemption?
Formats: Paperback, Kindle, audiobook
THIS IS WHAT I WANT
This Is What I Want, the story of an oilfield town struggling with change amid its annual old-timers' reunion, was published by Lake Union Publishing in 2015. It was a High Plains Book Award finalist.
Synopsis: In the sweltering heat of a Montana July, the small town of Grandview readies for its annual Jamboree. The event is meant to celebrate community, but this year tensions boil over, threatening to tear the town, and a family, apart.
Sam Kelvig, a third-generation resident, will do just about anything to protect Grandview from the influx of new oil money and the strangers chasing it. Meanwhile, his restless wife, Patricia, wearies of the constraints of marriage to a man who is so tied to his community; Sam's estranged son, Norby, has reluctantly returned home despite the family's struggle with accepting his sexuality; Henrik, Sam's volatile brother, is looking for any easy opportunity; and Blanche, the family matriarch, only wants a bit of peace before she dies. As Jamboree goes into full swing, the disputes and desires of the Kelvigs—and their friends and neighbors—collide, fueled by both longtime resentments and an irrepressible hope to preserve their family and hometown.
EDWARD UNSPOOLED
After a long wait, readers of Craig's series of books about Edward Stanton were rewarded in 2016 with the release of Edward Unspooled, the third installment. Published through Craig's Missouri Breaks Press, the book has met with wide acclaim. It was a finalist in the International Book Awards, a semifinalist in the Kindle Book Awards, and the overall winner for general fiction in the Best Book Awards.
Synopsis: Change keeps stalking Edward Stanton. He and his new wife, Sheila, have retreated to his small house in Montana after an unsuccessful attempt at operating a motel in Colorado. That failure has left wounds, especially for Sheila, and now they face a bigger challenge: pregnancy and impending parenthood.
Edward begins penning notes to the child (ever precise, he refers to the gestating being as "Cellular Stanton") as he navigates married life with Sheila, who is unhappy and unfulfilled in Montana; a work partnership with his friend Scott Shamwell, whose own life is teetering; and the emergence of a long-buried family secret and the effect of this revelation on his relationship with his overbearing mother.
Even as Edward's world expands, he must confront questions about whom to let in, how much to give, the very definition of family, the fragility of hope, and the expanses of love.
JULEP STREET
Released in 2017 by Missouri Breaks Press, Julep Street leaves the Montana of Craig's fiction and settles into Kentucky river country. It's a paean to the daily newspaper, where Craig plied his trade for many years. Hailed as a story that is at turns gentle and brutal, Julep Street was a finalist in the literary fiction category of the Best Book Awards.
Synopsis: Carson McCullough has given his career to a singular pursuit—putting out a small daily newspaper that keeps his employees engaged and his hometown informed. But as time and technology conspire against him, Carson's Argus-Dispatch is shuttered by a new owner with a different view of its future.
Stung by the abrupt end of his career and burdened by regret and grudges, Carson and his one true companion, a yellow Lab named Hector, set out on a road trip. As the miles pile up and Carson erratically drives into the residue of past decisions and the consequences of current actions, he confronts questions of love, faith, self-worth, and, perhaps most pressing, whether he can redefine himself after his identity is stripped away.
In his seventh novel, Craig Lancaster (600 Hours of Edward, The Fallow Season of Hugo Hunter) returns to the broad themes of his award-winning work and goes deeper yet, straight into the heart and mind of a good man who has lost his way and is struggling against himself to set things right..
Formats: Hardcover, paperback, e-book, audiobook
YOU, ME & MR. BLUE SKY
This novel, a romantic comedy co-written with Craig's wife, Elisa Lorello, came out January 27, 2019, under their Lancarello Enterprises imprint..
Synopsis: Jo-Jo Middlebury is done with love. Linus Travers wants one more shot at it. Mr. Blue Sky, their 1970s-loving guardian angel, offers perspective on both when he's not busy diving into reruns of "Happy Days" and "Barney Miller."
Linus can save Jo-Jo's business, but Jo-Jo makes it clear that she needs no one to rescue her, least of all him. Add to that an ex-fiancé with a change of heart, a single mom who wants a good time, and a married couple who've blurred the boundaries of their respective friendships with Linus and Jo-Jo.
All the while, Mr. Blue Sky observes, explains, and ever-so-gently interacts.
You, Me & Mr. Blue Sky is a warmhearted, humorous dive into the depths of love and the mysteries of how two people find their way to each other..
FIND CRAIG'S BOOKS AT A BOOKSTORE NEAR YOU
CHECK OUT CRAIG'S AMAZON PAGE
GET CRAIG'S WORK THROUGH AUDIBLE
Subscribe to Craig's mailing list

redpajama_set_name: RedPajamaCommonCrawl


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Q: Odd blank screen for Mail account login after unlocking keychain I have Mac OS X and I accidentally locked the keychain and after a while I unlocked it again but now the mail app is not signing in with my Gmail account. Why is that? When I enter my password it is stuck in this state.

A: I found the answer to my question which is as follows
I opened up the keychain preferences and deleted the mail keychain and typed the password for my mail then all set.

A: This happened to me after updating my password in a global environment, then this happened when i tried to update the login info for the mail app.
The Solution for me required deleting that entry in the accounts list and re-adding it.

redpajama_set_name: RedPajamaStackExchange


Stock up on a few safe, simple ingredients that can be used in most cleaning situations. Soap, water, baking soda, vinegar, lemon juice, borax, and a coarse scrubbing sponge can take care of most household cleaning needs. Of course, you can buy ready-made chemical and toxin free cleaning products, but be sure you know what you are looking for and that the manufacturing company is ethical and trustworthy. For general household cleaning, the following suggestions will save you money, reduce toxic chemicals in your home and prevent their flow-on effect in the broader environment.
- Normal washing powders cannot work as efficiently with hard water. In this formula vinegar and borax are used to soften the water.
A mixture of equal parts borax and sugar placed in jar lids under the cupboards and the refrigerator can help with keeping cockroach numbers down. Keep well away from children and pets.
Boil two-three inches of water in a shallow pan with 1 teaspoon of salt, 1 teaspoon of bi-carb soda and a sheet of aluminium foil. Totally submerge silver and boil for 2-3 minutes more. Remove silver from the pan and wipe away tarnish with a clean cotton cloth. Repeat if necessary.
This formula will safely clean painted walls and wallpaper (provided it is washable wallpaper).
The following sites list common chemicals found in household products that can damage your health.
130 m2 land saved p.a.
33 kg CO2 saved p.a.


Mining for coal? Not any more. The Indian government is currently looking to abolish the state run monopoly Coal India. Now this action is not just to increase the competition within the coal industry, but to also ensure that the Indian society , especially in the rural areas has access to coal derived power. The major causes for this disintegration are the fact that Coal India has to import expensive coal due to the scarcity of local coal,the coal mines are leased to companies in the cement and steel industries and that the government has to subsidise kerosene to areas with no power. By breaking up Coal India, the government is planning to reduce its trade deficit, increase innovation and efficiency amongst firms, lower power prices to customers, lower price inflation and ensure accessible reliable power to remote rural areas. Although it seems like this is a win win situation , let us remind ourselves that by breaking up a natural monopoly, the firms will face very high start up costs that can lead them becoming insolvent. Moreover, there seems to be a lot of corruption regarding the accessibility of power and the government has to take careful measures to ensure that rural power becomes a reality. Check out this interesting article and try to come up with your own evaluations.
This entry was posted in Theory of the Firm, Uncategorized and tagged Coal India. Bookmark the permalink.


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REVIEW: Tile Battle
Party GamePCQuit
by rgk22 May 20185 min readAdd comment
An approach to real-time strategy in local multi-player.
Type: Multi-player
Genre: Casual, Party, RTS, 4-Player
Developer: Masterstrike, LadrikDev
Publisher: Masterstrike
Release date: 4 Apr, 2018
In this local multi-player game, each player has waves of little soldiers swarming from their base. The aim? Destroy the enemy base, and then the enemy army! The twist? There is no direct control of the warrior, they can only be guided by marking directions on the map.
Tower Offense
Tile Battle marks an original entry in the dense word of local multi-player games. It reminds me a bit of a Tower Defense game, but instead of laying traps there are just spells and signposts to affect the various swarms. By that, I include other people's troops as well! This is quite an interesting idea. Let's say that you want your troops to assault the enemy fort. You place directions to make them turn and reach there. In the meantime, your adversary is doing the same. How about asking nicely for their army to lay down their weapons and let you slay them by the sword? Well, you can't actually do that, but you can nicely guide them out of your borders by placing the same markings as the one your own armies use. Basically, you constantly have indirect control of the flow of all the troops on the battlefield.
Lord of the Tiles
There are three factions to choose from, Orcs, Undead, and Humans. Each faction has different sorts of unique spells to choose before the battle, such as a boost to your troops or a trap. Always available is a lightning bolt to delete an enemy marking, and then there are power-ups to pick up on a map. There are many maps to choose from, each catered to the number of players entering the fray. Lack of content is certainly not one of this game's sins.
However, my biggest issue with this game is that everything takes place in real time. What's more, the previous commands disappear. Only four direction signposts per player exist at any given time, which means that it's very heavy on the micro-management side. Therefore, each player is constantly scrambling to make a path while the whole place is crawling like an ant colony. It is beyond chaotic.
Developer responded: I agree the game often feels too chaotic. I have plans to improve this with changes to the gameplay and additional options for game settings.
To make this system work, it would have been much better to segment the game into rounds, and during a round, the players have a few new permanent tiles to add to the map. That's how it goes in boardgames, and that's how Ultimate Chicken Horse and Trapper's Delight deal with the issue of affecting the layout of the level. Then there would be the satisfying feeling of making progress towards a Grand Conveyor Belt Army while sabotaging the enemy plans. But oh wait, next round the enemy corrected the trajectory with a new sign.
I don't know if my idea would have worked, but what I know for sure is that the current way the game works put several of us off. It was an exercise in frustration and a vertigo of control loss. When I was winning, I did not feel that I outsmarted my opponent, I just felt relief that somehow my mad button mashing had paid off, and relief that it was over and I could take a break. My friends instantly disliked the game, I have rarely heard them asking me to switch games so fast. Which is not a good sign for a party game.
One of the issues is that the game fails to communicate its controls and mechanics properly. Case in point, the buttons X Y A B are actually marking directions on a tile. This is fine once you get it, but the first minutes were painfully confusing when everyone was pressing A on the map, asking all the troops to go south. Buttons for spells (such as RT and LT) are displayed on the screen, which is good. It's just that we were expecting to be given the movement tiles rather than mashing the buttons like that.
Graphics are not particularly outstanding, but cute and readable. The game runs well, no crashes or bugs to report. The music had the appropriate fantasy tone and was much better than the usual party games. For those who care about that, there is no online component, it's just local multi-player.
Tile Battle has variety and a good idea of giving directions to waves of ants-lemmings-soldiers, however the execution is not quite there and the game is not satisfying to play. My friends and I are certainly not going to add it to our rotation, but still the developer made an encouraging first game and will hopefully use the experience to make something better next time.
Tagged as4-player, LadrikDev, Masterstrike, multi-player, party, rts, tile battle
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28 aprile – 30 giugno
Via della Spiga, 31 Milan
Starting on Wednesday 28 April, 2021, Lia Rumma Gallery is pleased to present "The Communicator" (2012), and "Ecstasy II"(2012), an installation of eight sculptures and a photographic work by Marina Abramović, at Via della Spiga 31, Milan.
The Serbian artist's works symbolise the transformation and revitalisation of empty spaces and places. In the wake of the Viavài project, and in parallel with the ATO Art Takes Over initiative, the owners of the empty storefronts of one of the main streets of the Fashion District host contemporary art exhibitions, visible every day and at any time, underlining Via della Spiga's eventful history and its link with the arts.
Abramović's works will thus dialogue with the installations by Monica Bonvicini and Ariel Schlesinger, presented by ATO Art Takes Over @art.takesover at number 48, and with Nathalie Du Pasquier's installation at Via della Spiga 52, presented by VIA Visiting Installation Art @via.exhibit
Life As Activity
The Hunter College Art Galleries are pleased to present 'Life as Activity: David Lamelas', an exhibition marking the artist's first solo show in New York in more than a decade. 'Life as Activity' focuses on Lamelas's experimentation with film and his examination of identity and narrative fiction in light of his ongoing insistence that his artistic practice has always, in one way or another, been grounded in his sense of himself as a sculptor.
Bertha & Karl Leubsdorf Gallery
3 novembre – 18 dicembre 2021
Ettore Spalletti 2019
The latest book by the Artist. Presented by Danilo Eccher.
Galleria Nazionale, Rome
Wednesday 15 December 2021, h 5.30 pm
"Waiting for Kentridge" at New Moroso space
This year's Piccolo Festival dell'Animazione will be opened by William Kentridge, the celebrated artist who opened the festival in virtual mode last year and is one of the leading figures on the international scene. Students and fans of cinematic animation will be able to see 12 of his films on video stations, monitors, computers and televisions placed around the new Moroso space, which has been renovated, in collaboration with Marco Viola Studio, in an industrial loft aesthetic of great relevance to contemporary ideas on visual presentation. The works are displayed unconventionally in a series of comfortable viewing lounges. William Kentridge will be present in person to open the festival and speak about his work and the exhibition at 18:00 on 19 November.
MOROSO DESIGN OUTLET
Via Nazionale 85, Tavagnacco (UD)
19 novembre – 10 dicembre 2021
Artissima
Hall White : Booth n.2 | Hall Black : Booth n.1
OVAL Lingotto Fiere
5 – 7 novembre 2021
Tobias Zielony | Verso - Safe House
Group show Curated by Irene Calderoni and Bernardo Follini
Fondazione Sandretto Re Rebaudengo
5 novembre 2021 – 30 gennaio 2022
Ottonella Mocellin - Nicola Pellegrini | The Wall Between Us
From 16 October 2021 to 9 January 2022, MA*GA in Gallarate (VA) hosts the exhibition The wall between us, the result of a lengthy research process that artists Ottonella Mocellin and Nicola Pellegrini carried out for years, and in 2020 won the eighth edition of the Italian Council, the program for the promotion of contemporary art worldwide by the Directorate General for Contemporary Creativity of the Ministry of Culture.
MAGA Museum
16 ottobre 2021 – 9 gennaio 2022


Core i3-7100T is a 64-bit dual-core low-end performance x86 desktop microprocessor introduced by Intel in early 2017. This chip, which is based on the Kaby Lake microarchitecture, is fabricated on Intel's improved 14 nm+ process. This processor, which has a base frequency of 3.4 GHz with a TDP of 35 Watts, supports up to 64 GiB of dual-channel DDR4-2400. The i3-7100T incorporates Intel's HD Graphics 630 IGP operating at 350 MHz with burst frequency of 1.1 GHz.
This model has a configurable TDP-down frequency of 2.40 GHz.
Facts about "Core i3-7100T - Intel"


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You are here: Home / Health / Medicine / Weather shuts down blood donor drives, increases need
Weather shuts down blood donor drives, increases need
January 15, 2014 By Matt Kelley
With last week's extremely cold weather, more than 300 blood drives across the region were canceled and the American Red Cross missed out on collecting some nine-thousand units of blood. April Oppliger, spokeswoman for the Red Cross chapter in Omaha/Council Bluffs, says an appeal is going out for donors across Iowa to come forward. "The Red Cross is encouraging platelet donors and especially O-negative, A-negative, B-negative and O-positive donors to come out and help us replenish the blood supply."
The weather phenomenon known as the polar vortex, which brought Iowa wind chill levels of 50-below zero last week, isn't the only culprit that's kept donors away. Oppliger says, "It's the time of year where people are afflicted with colds and flu so all of those things combined make it especially important that people come out and give blood right now."
She says winter is traditionally one of the slowest times for donations anyway, so the severe cold that forced blood drive cancellations has compounded the problem.
"Every single one of those blood donations that was missed are units that we had promised to our hospitals," she says. "That's why it's extremely important for people to come out and give blood and platelets now." To make an appointment anywhere in Iowa, call 800-Red-Cross.
Filed Under: Health / Medicine, News Tagged With: Red Cross
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Morningside and Grand View collide for NAIA crown
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text:
Dain Rauscher Reps to Get Web Pages
Dain Rauscher brokers will have personal Web pages in January, reps learned at the firm's Association of Women Brokers conference in Minneapolis in October. In development right now, each rep's page will include certain basics as well as some custom information.Attendees also got an update on the progress of Dain Rauscher Connect, the firm's online access service. About 10,000 clients have signed
Dain Rauscher brokers will have personal Web pages in January, reps learned at the firm's Association of Women Brokers conference in Minneapolis in October. In development right now, each rep's page will include certain basics as well as some custom information.
Attendees also got an update on the progress of Dain Rauscher Connect, the firm's online access service. About 10,000 clients have signed up for the free service since its debut in June, according to Marcia Hansen, manager of policy and administration for Dain's retail group. The goal is to have about 100,000 clients online by the end of next year, she said. Eventually, clients will access account information through their broker's Web page.
Dain Rauscher will also be offering online trading via a fee account, said Chris Crosby, vice president and director of Internet. The firm is still working on all the pieces of the project and has no time frame for a rollout, Crosby later confirmed to RR.
John Appel, vice chairman and CFO, reminded the audience that industry changes previously perceived as detrimental, such as deregulation and discounters, in fact brought industry growth. He predicted that online firms and their advertising efforts would do the same.
Dain itself debuted its first television commercials in late September. The 30-second spots are running in the firm's main markets of Minneapolis, Dallas, Denver and Seattle. The ads have the tagline, "What you need to know," which highlights common mistakes and misperceptions held by investors.--Janis Samaripa
TAGS: Archive


text:
e2pandas
A usergroup for people who like nerding over (or bitching about) linguistics, english usage, punctuation, and giving each other writing feedback. Named after "eats, shoots and leaves".
Venerable members of this group:
oakling, wordnerd, Wiccanpiper, Ira, isogolem, eliserh, TenMinJoe, skybluefusion, androjen, swankivy, Andrew Aguecheek, Tiefling, princess loulou, Tato, exceptinsects, gwenllian, QuantumBeep, Segnbora-t, RPGeek, Kit, The Lush, redbaker, fuzzy and blue, Noung$, Helen4Morrissey, themanwho, Myrkabah, Footprints, Darksied, jrn, Major General Panic, squeezie, Auron, Hyphenated, Serjeant's Muse, Dimview, libertas, KilroyWasHere, shaogo, loughes, OldMiner, lizardinlaw
This group of 42 members is led by oakling
Amateur side (thing) by dannye Thu Sep 26 2013 at 21:34
linked by gwenllian
When playing a round of golf, one of the quickest ways to win or lose is to make or miss a 3 foot putt. Several misses like this can cause even Tiger Woods to snap a putter in half or toss it in the lake.
The influence of break can have on a short putt is usually determined by the type of grass on which you are putting. In America there are three usual grasses used for greens: Bermuda, Poa annua and Bent grass. I live in the South where most courses went through a period of trying Bent Grass even when the climate did not suit such grass. The reason it was tried was because Bent grass putts so smoothly. It putts so smoothly that a spike mark can throw it off line. That is why you see so many golfers wearing "soft spikes" ( a rubber spider-looking things, compared to the metal spikes still worn by most pros). When it's happy, Bent grass makes for the perfect putting surface. To make it happy requires three things; a cool climate, a lot of mist, and a constant wind flow. There's not much we can do about the climate, at least that is my political position, it likes to be moist but not drenched, so even though it would be cheaper to put in a watering system around the green, that would result in drenching, so the greens keepers' minions were tasked each scorching day with using a hose to spray the greens with a gentle mist (usually referred to as "syringing"), and fans are often installed in protected areas in order to supply the wind flow needed. So when it came to a place like Florida where there are thousandsupon upon thousands of golf courses, two things happened.
New strains of Bermuda were invented and the Bent grass greens were removed and replaced.
These strains of Bermuda have come to be the choice for green coverings in most of the South.
The worst greens I ever putted on were Poa annua on a course overlooking San Francisco Bay. Missing 3-footers became the norm and I was pissing mad by the time the round was over. That's not fun. The joke down here is that the seeds of Poa annua will stick to your shoes and you'll ruin your nice zoysia lawn by infecting it with those seeds. It's a weed down here.
If the putt breaks from left to right and the low side of the whole is on the right your usual miss would be on the lower side, to the right. This would be called the "amateur side." If you miss it on the high side to the left, that would be called the "Pro" side.
These two appellations probably came about from what an old guy told me one day after I missed on the amateur side. He said, "Mathematicians say that 90% of those that don't get to the hole do not go in. It is quite true that if you're on the high side, and the putt is breaking left to right, there is a possibility that it could hit a spike mark or a wind gust that would cause it to fall in." When you hit a putt too lightly and if it doesn't get much more than halfway to the hole, you run the risk of your playing partners making a remark such as, "Does your husband play?" It's very embarrassing to lose a few bucks to strangers who fail to hit it out of their own shadow half the time.
don't waste punctuation (idea) by klamech Tue Sep 23 2008 at 2:58
linked by Danneeness
Actually, extra punctuation is a bit like swearing: if you do it too much people will get offended, and 'doing it more adds more emphasis' is only true up to a point, after which you just seem like a bit of a moron.
'No!' is the equivalent of 'No!'
'No!!' is the equivalent of 'No, bugger it, no!'
'No!!!' is, in the rare situations in which it's justified (bearing in mind you're talking to strangers), the equivalent of 'Fuck no!'
'No!!!!' is the equivalent of 'fuckety fuckety shit-wank no, yah cunt!'. In other words, it doesn't make you seem extra-emphatic, it just makes you seem silly.
further investigation of farther (thing) by shaogo Thu Dec 06 2007 at 2:19
There it was, glaring out from the middle of the page like the cadaver of a New York City cockroach lying legs-up in the middle of a bowl of freshly-whipped heavy cream. The writer had misused the word further:
The bowling ball with the teflon coating traveled further down the track than did the conventional ball.
Just to be certain, I clicked on Words and Expressions Commonly Misused, a chapter of the exquisitely informational yet sublimely brief The Elements of Style. Lo and behold, I Strunk out! "Further" wasn't there, neither was farther.
To worsen matters, Webster 1913 opined primarily, that the words "further" and "farther" were essentially interchangeable. For heaven's sake how long ago could it have been that I'd read a marvelous piece by William Safire in The New York Times Magazine which specifically pointed out that the word "further" was being misused more and more often. Had Safire been in my town at that time, I'd have literally ran miles just to visit his hotel room, shake his hand in thanks and hug him. Thank goodness Mr. Safire's location was at that time unknown to me. Suffice it to say he was farther away than I could drive to see him, much less run.
Oh, how often in business meetings do we hear "this project is just in the planning stages, the implementation phase is much further down the pike." No, no, no.
This project is just in the planning stages, the implementation phase is much farther down the pike. Further analysis of market research will be necessary before expenditures and efforts are made to take the campaign national.
Now, that's more like it.
The explanation for the difference between our beloved turn-of-the-century dictionary and modern usage was pointed out by www.hubpages.com:
Further relates to a metaphor for distance or depth. It's an unquantifiable time, degree or quantity. It also means "additional," or "more."
Further refinements to the site's code will be made as necessary.
Alicia and Marian were instructed by the Dean to give some further thought about again displaying their affection for one another in public places on campus.
Had there been any further harassment of his incredibly beautiful, large-busted employees, Brett was willing to scrap the project and cancel the contract.
Farther relates to a conceivably measurable distance, a point on a finite scale, or even a hypothetically exaggerated distance:
Sinatra topped the charts most often; Dean Martin and Sammy Davis, Jr. next, with Perry Como farther behind, a distant fourth with only six top-ten hits.
Cars of equal make, model and accessories traveled up to one mile farther on a gallon of gasoline containing the additive "Extrol."
Jeremy's peculiarly large penis made the other Abercrombie models jealous; if he didn't wear briefs, it would hang farther than the limits of even the most generously-sized shorts.
I found Mr. Safire's article, "Simpsonese" in the "On Language" column of The New York Times, September 18, 1994 here. I've reprinted the relevant portion below:
"The aim of NATO's future expansion," the Clinton Administration's National Security Council staff writes in its strategy statement, "will not be to draw a new line in Europe further east, but to expand stability, democracy," etc.
Quoting this line in a recent polemic, I put a [sic] — the Latin word for "so, thus" to mean "error in the original" — after further. That's because the word for distance is farther, and the word for degree or expressing a sense of "beyond" is further. Furthermore (only say "farthermore" in the Situation Room), you can use further to mean either degree or metaphoric distance, but you should use farther only for physical distance.
UPDATE 12/19/2007: I changed the example sentence at the beginning of this writeup to a more overt example of the improper use of "further" than my original, which I concede was confusing.
maxclimb wrote: " Fowler's Modern English Usage points out that futher is 'the comparative of fore' indicating 'more advanced' and that farther is a variant of further but that the perceived connection to far leads to the notion of 'more distant'. He points out that most people use one OR the other in all cases. He concludes by stating that as a verb, further wins hands down. One of my pet bits of usage trivia as well.
hapax insists, however, that the terms are interchangeable freely, and agrees with Webster 1913.
http://www.englishrules.com/writing/2005/farther-and-further.php
http://www.cjr.org/resources/lc/farther.php
http://journalism.about.com/od/proofreading/qt/furtherfarther.htm
Prosenoder's Cup 2007 (person) by everyone Thu Mar 08 2007 at 4:14
linked by libertas
Baroness Thatcher
She wasn't ready.
She looked up at him and a surge of warmth hit her in the throat. She looked down again and saw his bags, everything he treasured packed neatly inside, sitting on the floor on either side of him. He was clutching his ticket.
She'd known it was coming. She wasn't ready.
"I'll call you," he said. "As soon as I get there, I promise." She smiled, intending to nod but couldn't move.
A tear slid down her cheek. She wasn't ready.
"Don't cry, love," he whispered, smoothing her hair with the palm of his hand. "You know I hate to see my lady cry." He pulled her into his arms, knowing full well that she was wondering why he was leaving her, and he didn't have an answer. He'd been offered a job – a good job – out of town, of course, and it was she who urged him to follow his heart and take it.
But she wasn't ready.
He thought about all the other hard goodbyes that took place in that train station. Relocation. War. And those who, like him, were reluctantly breaking someone's heart.
He held her for a long time; she silently hoped he'd change his mind. Something about the final boarding call came over the loudspeaker and she felt the blood rush from her face. He repeated his promise to call and added a second to return. He picked up his bags and turned to go; she shut her eyes and turned sideways.
Don't turn around, she thought. The lady's not for turning. But she turned around anyway, just in time to see him slip through the door and out of sight.
She shrunk onto the floor, her back pressed against the pillar, and sobbed uncontrollably.
Comma Splices and Run-on Sentences (thing) by Rancid_Pickle Tue Oct 17 2000 at 16:38
linked by skybluefusion
A comma splice occurs when two independent sentences or clauses are spliced together with a comma.
Wharfinger just found thirty dollars, he wants to buy a bucket of soy.
Everything2 is a nifty website, posting here improves my writing skills.
There is a complete clause before the comma and after the comma. There are several ways to correct comma splices:
Separate the clauses and make them separate sentences.
Wharfinger just found thirty dollars. He wants to buy a bucket of soy.
Everything2 is a nifty website. Posting here improves my writing skills.
Link the two closely related clauses with a coordinating conjunction, such as and, but, or, nor, for, so or yet.
Wharfinger just found thirty dollars, so he wants to buy a bucket of soy.
Everything2 is a nifty website, and posting here improves my writing skills.
Link the closely related clauses with a semicolon.
Wharfinger just found thirty dollars; he wants to buy a bucket of soy.
Everything2 is a nifty website; posting here improves my writing skills.
Reword the sentence to create one independent clause.
Wharfinger wants to buy a bucket of soy with the money he found.
Posting on the nifty website Everything2 helps to improve my writing skills.
Run-on Sentences
The secret to writing well is to write concisely. Everyone is guilty of padding their writing with fluff and flowery language. Run-on sentences usually appear when you're trying to shove too much information into one sentence. A fellow Everything2 member named Lith pointed out that most run-on sentences are actually comma splices without the comma.
Every sentence must have a separate idea. A well crafted sentence has one main noun and an associated verb. Modifiers for the nouns and verbs will reveal your style of writing.
Examples of Run-On Sentences:
I enjoy reading her nodes she writes funny stuff.
I posted a node about trolls they really make me angry and when I find one under a bridge I will make him write a coherent node and then I will make him post it.
Use the same suggestions for separating comma splices. Break up these sentences into complete sentences, or use coordinating conjunctions.
I enjoy reading her nodes. She writes funny stuff.
I posted a node about trolls. They really make me angry. When I find one under a bridge I will make him write a coherent node. I will then make him post it.
Suggestions for modifying this node are welcome. Please /msg Rancid_Pickle in the chatterbox if you have any suggestions. Special thanks to Wharfinger for unknowingly volunteering to buy that bucket of soy.
older ->
dichotic gender paradigm
Never Forget the Ghosts


Radio is increasingly giving voice to various communities in India and evolving to remain significant.
There was a time when a radio was a must-have in every Indian house. A messenger to the masses, it gave us memorable moments and was the primary source of scoop. For some, listening to it was a morning ritual, and to some it was a companion. With the passage of time, it has, like many other mediums, undergone a sea change, and it continues to evolve in the digital age. But what remains unchanged is its essence.
It is a source of nostalgia for those who have grown old with it. "People think that radio is dead and that TV has taken over. I don't agree with them, for it is irreplaceable," said veteran All India Radio (AIR) broadcaster Jasdev Singh. "As long as you have a radio, you have the world in your pocket!" he added.
For Vijaya Laxmi Sinha, retired deputy director general of AIR, what radio meant to people back then is indescribable. "Radio, being the primary source of information for many, was listened to attentively, which in turn, put a lot more responsibility on part of broadcasters, as what was said would not go unnoticed," she said.
Over the years, advancement of radio technology and diversified programming have dramatically impacted the audience. What else has changed?
"The audience hasn't changed. It depends on how you present the content," said Neelesh Misra, presenter of the popular Yaadon Ka Idiot Box, who revived the story-telling format on radio. However, he agrees that there is a great immediacy now and the greater calm that used to be on radio at one point of time has gone.
In the younger lot of radio jockeys, there are also some who believe that change is not bad, provided we adapt to it. "Commercialisation is a product of privatisation and one can't avoid it," said Radio Jockey Suroshree Dutta of Hit 95 FM, whose love for music drove her to radio. "Nothing has changed. Like earlier, radio is still fulfilling its task of creating awareness among people, but in an informal and friendly way. Sometimes, we do it through music, other times we do it through discussions," she added.
"Transition expands the horizons. With the rapid emergence and increase in the number of community radio stations, it is empowering people even more," said Rajiv Tikku, Director and Editor-in-chief, OneWorld South Asia. "Programming has improved over the years and caters to a wider section of the society now," he added.
To celebrate World Radio Day, we look at some unique initiatives which cater to the needs of various communities across India.
In a bid to support queer culture, Anil Srivatsa, CEO and co-founder of the Radiowalla Network Pvt. Ltd, started a gay-centric community web radio channel called Q radio, a first-ever in India, giving voice to members of the LGBT community. The radio channel, which started operating from Bengaluru, went live in September last year.
With the intent of assimilating the gay community and society at large, the channel in its infancy, struggles to rope in the right team on place. "We hope people will embrace it and become part of our team to take it to the next level," he added. The channel has been partially funded by United Nations Development Program and Guild of Women Achievers, an NGO.
A platform for multiple radio channels, the group has so far been successful in setting up more than twenty channels, including one for the Armed Forces- Fauji Radio.
Mann Deshi is a micro-credit bank in Mhaswad village in Satara district of Maharashtra. An initiative of a foundation with the same name, it was set up with an objective of empowering local women by imparting entrepreneurial skills through its non-financial services. In a bid to reach out to women to make them aware about its programs, the organization, in 2009, came up with the idea of starting its own community radio station called Mann Deshi Tarang.
With a radius of 60 kilometer, the radio service is accessible to 110 villages and provides eight hours of local programming in Marathi everyday. "We help women expand their business by advertising their products, sharing inspirational success stories, and inform them about our vocational training programs and workshops," said farmer turned social entrepreneur Chetna Gala Sinha, founder, Mann Deshi Foundation.
"To keep them updated about our Mobile Business school, we announce the bus routes on radio, and also provide them with our phone numbers to enable them to share the community related problems with us," she added. To make it more accessible and participatory, a speaker has also been installed at the village's main bus stop, and in radio clubs in schools.
The radio team has been trained by CEMCA (Commonwealth Educational Media Centre for Asia) through its workshops on content development and technical training. "We have also been trained in generating programs on health related issues as well as engaging topics such as debate and quiz competitions, enabling us to serve and benefit the whole community," said Sinha.
With Jnan Tarang, the north-east of India got its first ever community radio service. Operational from the Krishna Kanta Handiqui State Open University in Guwahati since November 2010, it was the dream project of Dr. Ankuran Dutta (33), a former lecturer at the university.
The university got the first nod from the Ministry of Information and Broadcasting in 2009 for flagging off the radio service on an experimental basis for two days. Regular broadcasting started a year later in November. "Apart from educational issues, socio-cultural issues are also broadcasted to benefit the community too," said Dutta. The Jnan Tarang radio is accessible within 10 km of radius from the university campus.
Getting started proved challenging. "The licensing process is difficult since it involves many ministries. It took two years for our case," said Dutta.
According to him, services such as Jnan Tarang voice the opinion of the masses more efficiently as compared to government-run public broadcasting services and profit-oriented private FM channels. "As per the anthropological survey of India, the Seven Sister states of the north-east comprise of 375 ethnic groups. It is not possible for mainstream channels to cater to each of these. Hence, nothing can match the scale and wonder of community radio here."


The Dumbo Salt Works is 2000 square feet of raw loft space available to rent for photo shoots and film productions. The Salt Works has 14 foot ceilings, 5 enormous arched windows, wireless internet, and a freight elevator for your convenience.
Our location is not in a New York City Red Zone for filming (or photo shoots).


Spitfire Automotive provides Tire Rotation services to Oak Lawn, IL, Alsip, IL, Chicago, IL, and other surrounding areas.
Why Should You Have Tire Rotation Services Performed at Spitfire Automotive?
We proudly service the Tire Rotation needs of customers in Oak Lawn, IL, Alsip, IL, Chicago, IL, and surrounding areas.


Good practice exchange and awareness raising during the Stoffenmanager Users' Day - a Cosanta event part of the European Week for Safety and Health at Work.
5th Sympoisum on "Dangerous Substances - sampling - analysis - assessment"
Konferencja pn. "Wszystko co chcielibyście wiedzieć o chemii" / Conference "Everything you would like to know about chemistry"
The conference, organized as part of the European information campaign 2018-2019 "Manage dangerous substances", took place on October 23 at the Faculty of Chemistry, University of Lodz (Lodz, Poland).
How do companies practically manage dangerous substances ?


text:
@interface ChromeNavigation : CDVPlugin {
    NSURLRequest* _chromeAppRequest;
    NSTimer* _pageRefreshTimer;
}
@end

static NSString *stripFragment(NSString* url)
{
    NSRange r = [url rangeOfString:@"#"];
    if (r.location == NSNotFound) {
        return url;
    }
    return [url substringToIndex:r.location];
}

@implementation ChromeNavigation

// Taken from CDVWebViewDelegate.
- (BOOL)request:(NSURLRequest*)newRequest isFragmentIdentifierToRequest:(NSURLRequest*)originalRequest
{
    if (originalRequest.URL && newRequest.URL) {
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- (void)doReload {
    NSLog(@"location.reload() detected. Reloading via chromeapp.html");
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- (void)checkForDevToolsRefresh {
    NSString* gotToken = [self.webView stringByEvaluatingJavaScriptFromString:@"window.__ChromeNavigationLoadToken"];
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- (BOOL)shouldOverrideLoadWithRequest:(NSURLRequest*)request navigationType:(UIWebViewNavigationType)navigationType
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            [[UIApplication sharedApplication] openURL:url];
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redpajama_set_name: RedPajamaGithub


text:
TREM2-DAP12 prevents the degradation of IKB induced by PMA, suppresses p65 NFB phosphorylation induced by PMA and in addition prevents NFB transactivation induced by PMA teaching globally that TREM2-DAP12 antagonizes NFB activation induced by PMA. sets off TREM2 signaling. Specifically, we present that APOE4 stimulates spleen tyrosine kinase (SYK) activation even more potently than APOE2 within a TREM2 reliant manner. Oddly enough, TREM2 seems to antagonize NFB activation induced by phorbol ester but struggles to prevent TNF induction of NFB activation recommending that TREM2 antagonizes inflammatory occasions Anastrozole prompted downstream of PKC. TREM2 mutations significantly influence TREM2 phagocytosis aswell as its capability Anastrozole to antagonize NFB activation and notably avoid the activation from the PI3K/AKT pathway noticed with wild-type TREM2. Overall our data claim that TREM2 reliant phagocytosis needs an activation from the SYK/PI3K/AKT/PLC pathways as the suppression of NFB activation by TREM2 is normally unbiased of SYK, PI3K, and PLC actions. This style of ectopic TREM2-DAP12 co-expression shows up suitable to review TREM2 signaling as many biological features of TREM2 and TREM2 mutations which have been previously defined in myeloid and microglial cells had been also replicated within this model. allele, which represents the most powerful genetic risk aspect for late starting point Advertisement (Ulrich et al., 2017; Yeh et al., 2017; Carmona et al., 2018). The most frequent Advertisement TREM2 variant outcomes from an individual nucleotide polymorphism encoding an arginine to histidine missense substitution on the amino acidity 47 (R47H) (Guerreiro et al., 2013; Jonsson et al., 2013). Oddly enough, APOE is normally a known ligand for TREM2 and many AD-associated mutations in TREM2 impair APOE binding (Atagi et al., 2015; Yeh et al., 2016) recommending these two Advertisement risk genes could possibly be mechanistically connected. A oligomers are also shown to connect to TREM2 with high affinity also to stimulate NFAT (nuclear aspect of turned on T cell) GluA3 signaling while in TREM2 Advertisement variations, however the A affinity for TREM2 continues to be unchanged, NFAT signaling induced with a oligomers is normally reduced recommending a partial lack of TREM2 function (Lessard et al., 2018). TREM2 is normally involved with microglia phagocytosis and activation as TREM2 knockdown inhibits phagocytosis and stimulates the creation of inflammatory cytokines by microglia while TREM2 overexpression gets the contrary impact (Takahashi et al., 2005). BV2 microglial cells expressing Advertisement TREM2 variations present impaired phagocytic activity recommending TREM2 lack of function for these variations (Kleinberger et al., 2014). TREM2 indicators through its association with TYRO protein tyrosine kinase binding protein (TYROBP), also called DNAX-activating protein of 12 kDa (DAP12), which recruits the spleen tyrosine kinase (SYK) through its cytosolic immunoreceptor tyrosine-based activation motifs (ITAMs) (Peng et al., 2010). SYK continues to be therefore postulated to be always a key kinase necessary to transduce TREM2 signaling pathways. TREM2 signaling provides anti-inflammatory implications and provides been proven to antagonize Toll-like receptor (TLR-4) mediated irritation by modulating the JNK and NFB signaling pathways (Takahashi et al., 2005; Hamerman et al., 2006; Zhong et al., 2017a). A lot of the research on TREM2 signaling possess utilized anti-TREM2 antibodies to stimulate the TREM2 receptor marketing the connections between TREM2 and DAP12 as well as the recruitment of SYK (Varnum et al., 2017). Up to now, the only tries to review TREM2 signaling in response to receptor ligation with APOE have already been conducted through the use of indirect calcium-driven reporter Anastrozole systems without obviously delineating which signaling pathways are prompted or antagonized upstream from the reporter. Such useful analyses nevertheless have got, recommended that APOE can be an agonist of TREM2 (Jendresen et al., 2017) which several TREM2 Anastrozole variations associated with Advertisement impair TREM2 activation whereas various other variations opposingly boost TREM2 activation in response to phosphatidylcholine and various other lipid ligands (Melody et al., 2017) recommending that Advertisement TREM2 mutations aren't simply lack of function mutations as previously idea. Anastrozole To research the functional function of TREM2 on Advertisement pathology, several research have examined the influence of TREM2 insufficiency on A deposition and tau pathology using several transgenic mouse types of Advertisement as Advertisement linked TREM2 mutations had been assumed to derive from TREM2 loss-of-function phenotype (Cheng-Hathaway et al., 2018; Melody et.
Celina Fox January 19, 2022 Hydroxytryptamine, 5- Receptors Read more >
1b), a cellular protein that is localized to the endoplasmic reticulum and therefore excluded from exosomes15
1b), a cellular protein that is localized to the endoplasmic reticulum and therefore excluded from exosomes15. Functionally, we found that RMS-derived exosomes exerted a positive effect on cellular proliferation of recipient RMS cells and fibroblasts, induced cellular MG149 migration and invasion of fibroblasts, and advertised angiogenesis. These findings display that RMS-derived exosomes enhance invasive properties of recipient cells, and that exosome content material of fusion-positive RMS is different than that of fusion-negative RMS, probably contributing to the different metastatic propensity of the two subtypes. Rhabdomyosarcoma (RMS) is an aggressive childhood soft cells tumor thought to arise from primitive mesenchymal cells with evidence of myogenic differentiation (examined in ref. 1). RMS happens as two main histologic subtypes: alveolar (ARMS) and embryonal (ERMS) histologies. The alveolar subtype is definitely characterized, in the majority of cases, by a chromosomal translocation t(2;13) (q35;q14), resulting in the fusion of the gene encoding the DNA binding website of Paired Package 3 (PAX3) with the gene encoding the transcriptional activation website of Forkhead Package O1 (FOXO1, previously known as FKHR) on chromosome 13 (reviewed in ref. 1). An alternate chromosomal translocation t(1;13) (p36;q14) results in a fusion between PAX7 on chromosome 1 and FOXO1, SPTAN1 and occurs in a minor proportion of ARMS (reviewed in ref. 2). These ARMS-specific translocations result in an oncogenic PAX3-FOXO1 or PAX7-FOXO1 fusion protein, respectively, which contribute to the aggressive and metastatic behavior of ARMS (examined in ref. 2). Indeed, ARMS tumors are metastatic at analysis in approximately 80% of individuals, as compared to only 20% in ERMS, and are associated with poor end result despite current multimodality therapy. Recently, it has been suggested that fusion status may be a better stratification marker than histology, and classification of RMS into fusion-positive versus fusion-negative (rather than ARMS and ERMS, respectively) may be more useful in prognostication and medical allocation of therapy3. Better understanding of the mechanisms by which both subtypes of RMS develop metastatic properties are needed, for development of novel therapies and improvements in end result of individuals with advanced disease4. Exosomes are small secreted membrane-bound particles measuring 30 to 120?nm in diameter, that have been shown to play important tasks in cell-cell signaling and cellular communication, promoting secretion MG149 of growth factors, cytokines, and angiogenic factors by stromal cells, proliferation of endothelial cells, and metastasis (reviewed in ref. 5). Upon endocytosis, exosomes deliver their active parts, including proteins, RNA and miRNA directly into the cytoplasm of recipient cells, and can influence their biological processes6. Emerging evidence indicates that packaging of miRNA into exosomes is not random MG149 and may rely on sequence-specific and secondary structure7,8. Exosomes derived from malignancy cells have been demonstrated to promote angiogenesis, invasion, migration and proliferation in recipient cells to support tumor growth9. Some of the most persuasive studies for an important part of exosomes are in the highly metastatic tumor melanoma, where transfer of protein via exosomes was shown to be responsible for preparing the metastatic market in multiple organs, thus facilitating melanoma metastasis10. In pediatric cancers, few studies possess investigated the part of exosomes in tumor biology. Studies reported that Ewing sarcoma, medulloblastoma, and neuroblastoma cell lines secrete exosomes, with specific identifiable cargo11,12,13. RMS is definitely a particularly interesting tumor where paracrine signaling is likely important, specifically the fusion-positive subtype, which is known to become highly metastatic. We hypothesized that RMS-derived exosomes enhance invasiveness of RMS cells and connected fibroblasts via paracrine signaling, therefore contributing to the known metastatic behavior of this aggressive tumor. Results RMS cells secrete detectable amounts of exosomes We evaluated a panel of 5 well-characterized RMS cell lines for exosome secretion. All tested cell lines of both fusion-negative (and embryonal histology) RMS, namely the JR1, RD and Rh36 cell lines, and the fusion-positive (and alveolar histology) Rh30 and Rh41 cell lines, were found to secrete small vesicles visualized using scanning electron MG149 microscopy (Fig. 1a, top panel). Measurement of the isolated vesicles diameter confirmed a size range of 40C120?nm (Fig. 1a, lower panel), consistent with exosomes5. The identity of these vesicles as exosomes was confirmed by analysis of their protein cargo, as western blotting showed that they contained the exosome protein markers TSG101, HSC70 and.
Celina Fox June 23, 2021 Hydroxytryptamine, 5- Receptors Read more >
Data Availability StatementN/A
Data Availability StatementN/A. and hair follicle formation, body's temperature legislation, muscle fat burning capacity, and tumor advancement. Within this review, we will PROTAC FAK degrader 1 summarize the existing knowledge of the functions from the RANKL/RANK/OPG system in natural processes. receptor activator of NF-B ligand, receptor activator of NF-B, T helper 17 cell, periodontal ligament Hereditary bone tissue diseases Due to its essentiality in osteoclastogenesis, dysregulation of RANKL signaling leads to impaired or extreme bone tissue resorption, and certain healing interventions in such dysregulated signaling have already been been shown to be effective in the treating bone tissue illnesses [1]. Mutations in genes encoding RANKL, RANK, and OPG result in hereditary bone tissue diseases in individual, such as autosomal recessive osteopetrosis (ARO) [23, 24], familial form of early-onset Pagets disease of bone (PDB2) [25C27], familial expansile osteolysis (FEO) [26, 28C30], expansile skeletal hyperphosphatasia (ESH) [31], panostotic expansile bone disease (PEBD) [32], and the Juvenile Pagets disease (JPD, or idiopathic hyperphosphatasia, IH) [32C37]. Mutations found in these diseases are PROTAC FAK degrader 1 summarized in Table ?Table11. Table 1 Mutations of RANKL/RANK/OPG genes in hereditary bone diseases intervening sequence, deletion, duplication, insertion, framework shift Bone redesigning under the influence of mechanical loading Mechanical loading onto bone maintains its morphology, amount, and quality. In instances of being bed-ridden or undergoing spaceflight, the body endures reduced mechanical loading, resulting in improved osteoclastic bone resorption and fragility. It is reported that unloading-induced osteoclastic bone resorption is definitely mediated by osteocyte RANKL (Fig. ?(Fig.1b)1b) [21]. On the other hand, bone remodeling by additional mechanical loading has been used in orthodontic treatment for a long time. Orthodontic force applied to teeth induces alveolar bone remodeling so that the selected teeth move toward the targeted destination. During such alveolar bone remodeling, osteocytes function as the major source of RANKL [38]. Therefore, as explained above, both unloading and loading conditions can induce the osteoclastic bone resorption, which is definitely mediated from the increase of osteocyte RANKL. The mechanism of precisely how this cytokine is definitely induced in osteocytes requires further study. PROTAC FAK degrader 1 Osteoporosis Osteoporosis is definitely defined as a disease characterized by low bone mass and microarchitectural deterioration of bone tissue caused by an unbalancing of the resorption-formation toward resorption [39]. This imbalance is definitely induced by alterations in hormone manifestation, nutrition, mobility, and/or senescence. Diseases and medication used to treat them can result in osteoporosis as well. Studies have shown that B cell RANKL, as well as osteocyte RANKL, to some extent contributed to bone loss inside a mouse model of postmenopausal osteoporosis, whereas that of T cells did not (Fig. ?(Fig.1b)1b) [40, 41]. Recently, it had been reported that soluble RANKL insufficiency did not have an effect on the severe nature of bone tissue loss within this model, recommending a job for membrane-bound RANKL towards the pathology of osteoporosis [16, 17]. Because inhibition of RANKL can ameliorate extreme bone tissue resorption by suppressing osteoclastogenesis, a individual monoclonal IgG2 antibody against RANKL denosumab provides become employed for the treating osteoporosis during the last 10 years in lots of countries [42, 43]. Romosozumab, a monoclonal antibody against sclerostin, provides began to be employed for osteoporosis sufferers extremely [44] lately. Sclerostin is normally a well-known inhibitor of Wnt signaling, and its own neutralization network marketing leads to an elevated bone tissue formation. Furthermore, sclerostin was proven to induce RANKL appearance [45, 46], and romosozumab lower bone tissue resorption via its inhibition. Inflammatory bone tissue loss Arthritis rheumatoid (RA) is normally a osteo-arthritis seen as a chronic irritation from the synovium and erosion of cartilage and KSR2 antibody bone tissue [47]. Within this framework, RANKL that mediate osteoclastogenesis is normally made by the synovial fibroblasts under swelling, as well as T helper 17 (TH17) cells, especially those that with a history of Foxp3 manifestation (exFoxp3 TH17 cells) (Fig. ?(Fig.1c)1c) [48C50]. Denosumab offers been shown to be effective in inhibiting the progression of joint damage [51], but its medical use is definitely approved in only a limited quantity of countries. Because denosumab was effective in the prevention of bone damage but not joint swelling or cartilage damage, it is desired to use this drug in combination with others, such as methotrexate and biologics [52]. Periodontitis is the most common infectious disease and the major cause PROTAC FAK degrader 1 of tooth loss owing to the loss of tooth-supporting bone, alveolar bone [53]. Bacterial penetration from the dental epithelium leads for an immune system response in the periodontium, producing exFoxp3 TH17 cells [15]. These cells generate interleukin.
Celina Fox December 24, 2020 Hydroxytryptamine, 5- Receptors Read more >
SARS-CoV-2, a novel coronavirus referred to as COVID-19 has generated a worldwide pandemic mostly
SARS-CoV-2, a novel coronavirus referred to as COVID-19 has generated a worldwide pandemic mostly. not really mutating like Btk inhibitor 1 R enantiomer hydrochloride nucleotides often. A repeated neural network-based Longer Short Term Storage (LSTM) model continues to be applied to anticipate the near future mutation price of this computer virus. The LSTM model gives Btk inhibitor 1 R enantiomer hydrochloride Root Mean Square Error (RMSE) of 0.06 in screening and 0.04 in training, which is an optimized value. By using this train and screening process, the nucleotide mutation rate of 400th patient in future time has been predicted. About 0.1% increment in mutation rate is found for mutating of nucleotides from T to C and G, C to G and G to T. While a decrement of 0.1% is seen for mutating of T to A, and A to C. It is found that this model can be used to predict day basis mutation rates if more patient data is available in updated time. is the final output array, is the output array sized 4??4 containing raw values after applying the algorithm, is the length of a dataset which is 3068 for the full dataset, 40 for China, 918 for Australia and 1903 for the USA, is the length of reference gene sequence which is 29903 in this dataset. In this process, we have calculated the nucleotide mutation rate for the prepared dataset. The mutation rate for China has been shown in Fig.?4 (a). It shows that a huge percent of Thymine (T) are being mutated to other nucleotides however, not making the same quantity of T once again. Also, plenty of Adenine (A) is certainly mutated to various other nucleotides. Evaluating to A and T, Cytosine (C) and Guanine (G) weren't changed much. Open up in another screen Fig. 4 Nucleotide mutation price for (a) China, (b) Australia, (c) THE UNITED STATES, (d) Remaining World. From then on, the mutation price has been computed for Btk inhibitor 1 R enantiomer hydrochloride Australia and the united states, and proven in Fig.?4(b) and (c). That is clear that rates have got a common aspect of experiencing the high mutation price of T and A. But there's a significant upsurge in the mutation price in comparison Btk inhibitor 1 R enantiomer hydrochloride to China. This obviously indicates that virus is very much indeed energetic in changing its gene series. Finally, the nucleotide mutation for the entire dataset of 33 countries provides been proven in Fig.?4(d). It implies that C and G mutation prices are almost add up to the united states because there are even more data of USA than every other countries. However, many adjustments in T and A is seen for the dataset from all of those other World. These beliefs vary in the availability of the info from different countries. 3.2. Codon mutation The next processed and transformed dataset which were ready previously continues to be used right here to calculate the codon mutation price, and proven in Fig.?5 . Adjustments in nucleotide trigger adjustments in codon established, which affects the protein directly afterwards. We have utilized the same algorithm proven in Fig.?3 for detecting the codon mutation price. A small transformation has been manufactured in the getting array where array size was 4??4 for nucleotide but here the array size is 64??64 for codon mutation. After locating the codon mutations, Eq. (2) continues to be used to obtain the prices in percentage. may be the last Btk inhibitor 1 R enantiomer hydrochloride result array, may be the result array size 64??64 containing organic beliefs after applying the algorithm, may be the amount of dataset which is 3068, may be the amount of the guide gene series which is 9967 within this converted dataset. The codon mutation price for the entire Mouse monoclonal to INHA dataset has been proven in.
Celina Fox October 14, 2020 Hydroxytryptamine, 5- Receptors Read more >


text:
Architecture Quotes
Little do we find any Phoenician architecture or plastic art at all comparable even to those of Italy, to say nothing of the lands where art was native.
– Theodor Mommsen
My guilty pleasure is I like to watch a lot of HGTV. I really like watching design shows about houses, like extreme homes. Like buying a bridge and turning it into a house or something like that. I really am interested in home design or something like that… architecture.
– Taylor Schilling
A world of few choices, whether in jeans or mates, is a world in which individual differences become sources of alienation, unhappiness, even self-loathing. If no jeans fit, you'll feel uncomfortable or inferior. If no housing developments reflect your taste for unique architecture, you'll write screeds against philistine mass culture.
– Virginia Postrel
Good buildings come from good people, and all problems are solved by good design.
– Stephen Gardiner
I mean, certainly writing, painting, photography, dance, architecture, there is an aspect of almost every art form that is useful and that merges into film in some way.
– Sydney Pollack
I've always been interested in an architecture of resistance – architecture that has some power over the way we live. Working under adversarial conditions could be seen as a plus because you're offering alternatives. Still, there are situations that make you ask the questions: 'Do I want to be a part of this?'
– Thom Mayne
Let us together create the new building of the future, which will be everything in one form: architecture and sculpture and painting.
– Walter Gropius
Architecture has recorded the great ideas of the human race. Not only every religious symbol, but every human thought has its page in that vast book.
What's fascinating about D.C., the exteriors are these elaborate structures, this gorgeous architecture and beautiful stonework, and then you go inside and it's crap-looking – apart from the White House, which is beautiful.
– Tony Hale
Princeton University's campus environment presents unique challenges and opportunities for architecture to act as a social condenser.
– Steven Holl
Architecture is unnecessarily difficult. It's very tough.
– Zaha Hadid
Architecture is the beginning of something because it's – if you're not involved in first principles, if you're not involved in the absolute, the beginning of that generative process, it's cake decoration.
Without this spirit, Modernist architecture cannot fully exist. Since there is often a mismatch between the logic and the spirit of Modernism, I use architecture to reconcile the two.
– Tadao Ando
I got into this little habit of architecture and building. I designed a house in Colorado and one in Hawaii. The idea is supposed to be build and sell – but then I can never bring myself to sell them.
– Trey Parker
We shape our buildings; thereafter they shape us.
Of course I believe imaginative architecture can make a difference to people's lives, but I wish it was possible to divert some of the effort we put into ambitious museums and galleries into the basic architectural building blocks of society.
I feel I can handle the architecture of dance as well as anybody.
– Twyla Tharp
I've gone to school for business, for design, for architecture.
– Venus Williams
The Egyptian contribution to architecture was more concerned with remembering the dead than the living.
I have a strong sense that every project is an invention, which is not a word I hear being used in architecture courses.
– Thomas Heatherwick
Downtown Toronto is a very good place to talk about the neutrality of modernist architecture. I'm sure this kind of box-building was interesting in the Twenties, Thirties and Forties, but I think it's absolutely ridiculous to build like this in 2013.
– Stefan Sagmeister
The aesthetic of architecture has to be rooted in a broader idea about human activities like walking, relaxing and communicating. Architecture thinks about how these activities can be given added value.
Architecture is how the person places herself in the space. Fashion is about how you place the object on the person.
I think architecture, to be really intense and fulfilling, doesn't have to be large.
Frank Lloyd Wright made houses right up until the end. I think that's important because it gives you a direct connection to all the basic aspects of architecture – the spatial energy of the place, the construction, the materials, the site, the detail.
Victorian architecture in the United States was copied straight from England.
The English light is so very subtle, so very soft and misty, that the architecture responded with great delicacy of detail.
The ancient Romans built their greatest masterpieces of architecture, their amphitheaters, for wild beasts to fight in.
– Voltaire
The idea was that you could grow a system like the Internet one network at a time and then interconnect them. In some sense, the most important thing was the invention of the architecture protocols that enabled the Internet.
– Vint Cerf
Architecture is the story of how we see ourselves. It is the architect's job to service everyday life.


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The AquaNerd Blog is back with more fun aquarium stuff to talk about, and in usual fashion we're taking a quick peak back at last week's top reads before we proceed. From the week of August 10th through the 16th, we read about Jebao's new DC skimmer, Orphek's new feature rich LED pendant, a drool inducing favia coral, a rare deepwater Hawaiian anthias, and EcoTech's foray into the freshwater side of the hobby. We hope you enjoyed the articles, and as always, we'll have another week full of aquarium hobby coverage ahead of us, so stay tuned.


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You can help us save lives and share the kindness of Jesus with people in incredibly challenging territories — including a newly accessible war zone experiencing what the United Nations calls "the worst humanitarian crisis of the century."
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It took TWO YEARS to get access to this place — 24 months while people have been waiting, hoping, praying for help. Global Aid Network® (GAiN®) is the very first Christian organization to receive permission to ship aid into this country. We have partners on the ground ready to distribute the aid and ensure it gets to people in need.
Right now 10 HUGE shipping containers of food, blankets, water filters, and other critical necessities — enough to help approximately 265,000 suffering people — are available and ready to go into this newly accessible nation and other tough places.
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