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text:
Q: Trying to call the stored procedure from C# windows form but nothing happens I'm trying to call a stored procedure from a C# windows Form application. It gets executed but nothing happens up in the database i.e no records are added to the table.
Here's my C# code:
private void buttonAddData_Click(object sender, EventArgs e)
{
    string actionTaken = "Added";
    string changeDescription = "Added new Code";
    string updatedBy = "ICherry";
    string currentStatus = "In development";
    SqlConnection conDatabase = new SqlConnection(@"Data Source=(LocalDB)\v11.0;AttachDbFilename=|DataDirectory|\ConfigData.mdf;Integrated Security=True;");
    try
    {
        SqlCommand cmd = conDatabase.CreateCommand();
        cmd.CommandType = CommandType.StoredProcedure;
        cmd.CommandText = "spLogConfigChanges";
        cmd.Parameters.AddWithValue("@ActionTaken",actionTaken);
        cmd.Parameters.AddWithValue("@ChangeDescription", changeDescription);
        cmd.Parameters.AddWithValue("@UpdatedBy", updatedBy);
        cmd.Parameters.AddWithValue("@CurrentStatus", currentStatus);
        conDatabase.Open();
        MessageBox.Show("Connection opened");
        cmd.ExecuteNonQuery();
        MessageBox.Show("Command Executed");
        conDatabase.Close();
    }
    catch (Exception ex)
    {
        MessageBox.Show(ex.Message);
    }
}

And my SP when executed in Query analyser runs with no errors and I can see the records being created.

A: instead of using
        SqlCommand cmd = conDatabase.CreateCommand();
        cmd.CommandType = CommandType.StoredProcedure;
        cmd.CommandText = "spLogConfigChanges";
        cmd.Parameters.AddWithValue("@ActionTaken",actionTaken);
        cmd.Parameters.AddWithValue("@ChangeDescription", changeDescription);
        cmd.Parameters.AddWithValue("@UpdatedBy", updatedBy);
        cmd.Parameters.AddWithValue("@CurrentStatus", currentStatus);
        conDatabase.Open();
        MessageBox.Show("Connection opened");
        cmd.ExecuteNonQuery();
        MessageBox.Show("Command Executed");
        conDatabase.Close();

try this:
conDatabase.Open();
    SqlCommand cmd = new SqlCommand("spLogConfigChanges",conDatabase);
cmd.CommandType = CommandType.StoredProcedure;
cmd.Parameters.Add("@ActionTaken",SqlDbType.Varchar).Value = actionTaken;
cmd.Parameters.Add("@ChangeDescription",SqlDbType.VarChar).Value = changeDescription;
cmd.Parameters.Add("@UpdateBy",SqlDbType.VarChar).Value = updatedBy;
cmd.Parameters.Add("@CurrentStatus",SqlDbType.VarChar).Value=currentStatus);

cmd.ExecuteNonQuery();
MessageBox.Show("Command Executed");
conDatabase.Close();

if you encounter some errors please comment

A: I had the same issue when I was using stored procedure I solved it by
changing this
cmd.Parameters.AddWithValue("@param", "String Value")

to this
cmd.Parameters.Add("@param", OleDbType.VarChar).Value = "String Value";

redpajama_set_name: RedPajamaStackExchange


text:
Andrew Chats with CALMLY
CALMLY, formerly known as Childsaint, are a rock band from Perth, Australia. They feature Chloe McGrath and Jane Azzopardi on guitar and vocals, Rhian Todhunter on bass, and Ashlyn Koh on drums.They recently played their first northern hemisphere shows at SXSW, where they were one of the highlights of the famous "Aussie BBQ." They caught up with Andrew to talk about influences, disco dancing, and "country drone doom":
Andrew: So these are your first shows in the northern hemisphere! How does it feel?
Jane: It doesn't feel real. Like I know that we're in America at the moment, but we're just gonna go play and do our thing, so it doesn't even register…we're curious what the crowds here are like!
Andrew: It's different everywhere in the country…I'm used to New York crowds and Minneapolis crowds–NYC is are rowdy, but not always the friendliest. Minneapolis crowds can be friendly, but they're definitely afraid to get down and dance. Don't know about Austin, though, since this is my first time here too.
Rhian: I'm hoping that this might be our opportunity to get a mosh pit going in the crowd, even though our style of music doesn't necessarily suit a mosh pit…
Andrew: Maybe it could be a new style of moshing!
Jane: The "new trend" in moshing.
Chloe: I would like that claim to fame of a new style of mosh.
Ashlyn: I'll be into that–CALMmoshing.
Andrew: Amazing. So what's your origin story?
Jane: I think Chloe and I got really drunk together one night and I said, "we should start a band."
Chloe: We wanted to start a band, and no one else was really keen, so it was just Jane and I playing together…wekind of forced Ashlyn to be in the band–she didn't want to play with us at first!
Ashlyn: I hadn't really played drums before…I think I'd played once.
Rhian: So they started playing as a trio, and one night I went up to them and said, "hey guys, can I play banjo in the band?" and they said "how about you play bass instead?"
Andrew: Did you have banjo experience?
Rhian: Nope.
Andrew: So you just threw it out there?
Rhian: Yep.
(all laugh)
Andrew: Have you ever tried it in the studio?
Rhian: No. We did one gig with it once, but it's not something I think we're going to go back to.
Andrew: Are there any artists growing up getting into music where you thought, "I have to do this?"
Chloe: There's this Australian band called The Drones that were pretty big for me…now the things I spend the most time listening to and getting direction from is a combination or country music and drone or doom.
Jane: We're kind of similar to that, I'd say.
Andrew: Country Drone Doom. I like it. It sounds like something you'd put on at a really cool college party and smoke weed to.
Andrew: Are there any artists you listened to growing up who made you who you are?
Ashlyn: Yeah, there were heaps of bands. I listened to a lot of emo music growing up, so really anything sad.
Andrew: So My Chemical Romance?
Ashlyn: More like Neutral Milk Hotel. Kind of MCR when I was very young, but I wouldn't say they were too big an influence.
Andrew: Have you gotten the chance to see Jeff Mangum live before?
Ashlyn: Yeah, I went to Atlanta a couple years ago and I saw him at a festival.
Andrew: It's always amazing when you can finally see one of your heroes in person. Did you talk to them?
Ashlyn: No, which was fine with me.
Andrew: I get that. What about you, Jane?
Jane: As a teenager, Cat Power and Feist for sure.
Chloe: I've been inspired by a lot of disco as well.
Andrew: Any particular artists? I went through a disco phase when I was 11.
Chloe: It'll come back around.
Andrew: It never left.
Chloe: My mom used to smash the Bee Gees when I was younger. Chic…
Andrew; Very important question–can you do the hustle?
Chloe: No,
Jane: I think it's an american thing.
Chloe: We'll find out in the next few weeks
Andrew: It's the iconic disco dance!
Rhian: Want to each it to us later?
Andrew: I would love to do that. 2018: the year Calmly learns to hustle. (All laugh). So you guys recently went through a rebrand any particular reason?
Jane: Well. There's an American band that's called Child Saint–with a space–and they made it very clear to us that they would prefer us to change the name. Once we decided to come here, we decided to switch it and go with CALMLY. It's unfortunate, but it is what it is.
Andrew: It's happened to a lot of great bands. Like Suede went by The London Suede in the USA, The Beat went by The English Beat, etc. Where did CALMLY COME FROM?
Chloe: Basically we just locked ourself in Ashlyn's apartment and decided we weren't leaving until we came up with a new name.
Rhian: It wasn't about finding something that we liked, but rather finding something that we didn't hate. We had a list that we all hated.
Andrew: What were some of the names that ended up on the cutting room floor?
Rhian: Oooh I don't know, I feel kind of embarrassed now..
Jane: What if we said one and you liked it more?
Andrew: I promise I won't.
Ashlyn: It was between Hot Mirage and Half-Shade. I wasn't really keen on either, and I just didn't care anymore! CALMLY came up and we just said "yeah…" it started as Calmer, but there was another band with a similar name, and we were so scarred by the Childsaint incident that we changed it to CALMLY and that was that.
Andrew: I like the name CALMLY. It's unique and evocative. Everyone likes being calm. It's a state everyone can aspire to.
Chloe: The definition of "calmly" in the dictionary is "without agitation or emotion," which is not at all our music.
Andrew: So you're gonna drop and LP soon, right? When can we expect that?
Rhian: Well it's been in the works for really long time, about three years. It took a while getting into the studio, it was a lot of time and money. We just finished a month ago, tracking the last couple of things and all.
Andrew: Do you have a name for the LP yet, or…?
Ashlyn: We haven't gotten that far.
Chloe: It'll be good, whatever it is.
Andrew: If we're used to what's been out, what can we expect from the new material?
Jane: It's definitely built on those songs, it's a bit different, a bit more dynamic maybe, more poetic, but still heavy on the distortion pedal.
Andrew: Thanks so much for sitting down with me! Are you doing a US tour soon?
Jane: Hopefully!
Andrew: Well if they do, everyone make sure to catch it.
Keep an eye out for more info surrounding the release of CALMLY's record!
Open in Spotify
Dream Setlist: Belle and Sebastian
Larissa Reviews The Proper Ornaments' "Six Lenins"
The Hottest of the Hottest: The Best #100-1 in the History of Triple J's Hottest 100
RPM Presents: Tunesday, 5/14/19
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Willie Reviews Rima Kato's "Sing-Song"
Al Pash Reviews SOAK's "Grim Town"

redpajama_set_name: RedPajamaCommonCrawl


SAN PEDRO CITY – The police arrested a male protester who was among a group of activists that attempted to disrupt President Duterte's Independence Day speech in Kawit, Cavite.
"Right now we have one who we are taking to the (police) station. Others were not arrested because they were minors," said Chief Insp. Mark Jason Gatdula, Kawit police chief.
The police could not immediately give the name of the protester but members of the Bagong Alyansang Makabayan-Southern Tagalog identified him as a certain "IC," a member of the militant overseas workers alliance, Migrante.
It was not immediately clear what charges the police would file against him.
Anakbayan-Southern Tagalog chairperson Mackie Valenzuela said around 10 activists made it into the crowd early this morning just as Duterte was about to deliver his speech at the Aguinaldo Shrine.
Valenzuela said the protesters, mostly youth activists, were able to chant "Duterte trahidor" (traitor) just before policemen shoved them away from the audience.
"He (Duterte) is a traitor just like (Emilio) Aguinaldo. All he's been giving us were fake promises, fake economic reforms as we see with the TRAIN (Tax Reform for Acceleration and Inclusion) law and Martial Law (in Mindanao)," he said.
Valenzuela said about 75 other activists would continue with the protest, but several meters away from the Aguinaldo Shrine, until Tuesday noon.


Wealthier Ontario seniors may be tapped to pay some of the cost of publicly-provided home care, Health Minister Deb Matthews said Tuesday.
The idea was one of 169 recommendations contained in a report, Living Longer, Living Well presented to Matthews. It is designed in part to reduce the skyrocketing health care costs for seniors, who account for about 50 per cent of the what the province spends on health care.
The 198-page report by Dr. Samir Sinha, director of geriatrics at Mount Sinai and the University Health Network Hospitals, recommended the Health Ministry explore an income-based system for home care and community support services.
Starting in August 2014, for seniors 65 years and older with an income of more than $100,000, the deductible for drugs is $100 plus three per cent of net income over $100,000, while for senior couples with a combined income of more than $160,000, the deductible is $200 plus three per cent of their family net income over $160,000.
Matthews told the Star, for example, there already is a user fee for Meals on Wheels.
"We are not the first province to think about it. In fact we are one of the last provinces to think about it. It's a recommendations and I think it's one that merits some thinking. But the bottom line is it would only apply to people who had the means to afford it," she said.
The Sinha report was commissioned as part of the province's Seniors Strategy announced a year ago.
Matthews said of the many recommendations the province is keenest on matching every senior with a primary care provider, be it a doctor of nurse practitioner who see that they get the continuum of care they need.
"The question is how can we afford not to do it because it actually costs the system a lot more when people aren't attached to primary care providers," she said.
He said for example "we need to triple the number of long-term care beds in our province" over the next 20 years while emphasizing the need to keep seniors in their homes as long as possible through improved home care and wellness programs.
Susan Eng, of the senior advocacy group CARP, said all the recommendations hold promise and called on the province to get busy implementing them.
"The single greatest concern for our members has been health care and access to health care," Eng, vice-president of advocacy for CARP.


text:
Check my flight
Flight Compensation
Claim Calculator
Missed flight
New: claim your ticket costs back in case of a flight cancellation due to the coronavirus crisis. Claim refund
Flight cancelled due to coronavirus?
You are entitled to the full refund of the price of your ticket.
Claim my refund
Flight delayed, cancelled or overbooked?
You may be entitled to up to €600 in compensation!
TAP Portugal: flight delayed, cancelled or overbooked? Here is what you should do
TAP Air serves 85 destinations in 35 countries and in effect delays, cancellations and overbookings are bound to happen. If your flight with TAP Portugal is disrupted then you may be pleased to hear that your passenger rights are protected. This also means that you may be entitled to compensation, even if you have missed your connecting flight.
Your passenger rights are protected when flying with TAP Air Portugal
Few passengers are aware that they may be eligible for compensation if their flight has been delayed, cancelled or overbooked. Although different criteria apply for flight delays and cancellations, your rights are protected by Regulation EC No 261/2004, if your flight departed from an airport inside the European Union, in most cases you'll be able to claim if you've arrived at your final destination with a delay of more than 3 hours (2 for cancellations). And, as established by the previously mentioned regulation, you can claim your compensation, in the United Kingdom and Ireland, up to 6 years after the date of the flight.
Claiming compensation from an airline can be a bit of a hassle, so here are our recommendations to make it easier. If you want to learn more about the regulation, which conditions apply and when, please visit our dedicated pages for flight cancellations and flight delays.
TAP Air Portugal: When am I eligible for compensation?
The following factors determine whether you are eligible for compensation for a delayed, cancelled or overbooked TAP Air flight:
The flight route: The European regulation states that you can claim compensation when a flight is operated by a European airline or if the flight takes off from an EU airport. Therefore, TAP Air Portugal flights are covered
Circumstances: The regulations also state that in order to claim compensation for a flight delay, cancellation or incident of denied boarding, the disruption must not have been a result of extraordinary circumstances.
The deadline for claiming compensation: In the United Kingdom and Ireland, it is possible to claim compensation up to 6 years after the date of the flight. The timeframe varies depending on the European country.
The total time of your delay: In most cases, you will be able to claim if you've arrived at your final destination with a delay greater than 3 hours. When it comes to cancellations, it's 2 hours.
Other criteria may apply. If you want to know more about the conditions that qualify you to compensation in the UK, then click here!
How much money can I get if I claim compensation for my delayed, cancelled or overbooked TAP Air flight?
Set by the legislation, the total amount you may receive in compensation is defined by the flight schedule and the distance between the airport of departure and arrival. Connecting flights are taken into account when assessing your situation. In other words, your whole booking is covered by the regulation. Consequently, it's the distance between your initial airport of departure and your final destination what will determine the total amount of money that you may receive in compensation for your delayed, overbooked or cancelled flight. Connecting flights are covered as long as they have been booked under the same reference. Put differently, if they are part of the same ticket or schedule.
For all flights covering a distance of up to 1,500 kilometres, you will receive up to £220
For all flights covering a distance between 1,500 kilometres and 3,500 kilometres, you will receive up to £350
For flights covering a distance greater than 3,500 kilometres, you are entitled to up to £530
Please remember that if your flight travelled a distance greater than 3,500 kilometres and it was delayed more than 3 hours but fewer than 4, then the total amount of compensation is reduced by 50%. The regulation defines the total amounts in euros and they are €250, €400 and €600.
You are entitled to service and care if you experience a long delay to your TAP Portugal flight
The airline should provide you with proper care in the event of a long delay or flight cancellation. This may include the following:
Meals and refreshments
Two different occasions in which you are allowed to establish communication with an individual of your choice (calls, emails, etc.)
Hotel accommodation if necessary (one or more nights) and transport from the airport to the establishment.
If you have incurred additional costs because you did not receive the corresponding assistance and/or care, you have the right to be reimbursed. Remember to keep all your invoices and receipts. The request for reimbursement may also be attached to your claim for compensation.
What Flight-delayed recommends when claiming compensation for your TAP Air Portugal flight
Below is a collection of helpful recommendations if you wish to proceed to claim compensation for your delayed, cancelled or overbooked TAP flight:
Keep a copy of your travel documents
Flight documents (boarding pass, booking confirmation, e-ticket, delay statement, etc.)
Receipts for additional costs (e.g. taxi, food and accommodation)
Remember and record the information of your disrupted TAP Air Portugal flight
The flight schedule (arrival & departure hours)
Length of the delay (final departure and arrival time)
Find out the reason for the flight's delay or cancellation
Ask TAP Air Portugal staff and crew
Check if other flights are delayed or cancelled (arriving at or departing from the same airport)
Check your flight for free with our claim calculator and find out immediately if you can claim compensation!
Enter the date and flight number of your TAP Portugal flight in our claim calculator below to see if you can claim compensation for your delay or cancellation. You will also know the total amount of compensation you may be entitled to.
What to do if you missed a connecting flight with TAP
Missed connections are also covered by the regulation. Let us explain! If your TAP Portugal booking originated from Europe and a delay or cancellation in any of your flights has made you arrive at your final destination with a delay of 3 hours or more, you can claim compensation. The catch: all flights must be under the same booking. The distance used to determine how much money you could get in compensation will be that between your initial airport of departure and the airport at your final destination.
When are you NOT entitled to compensation for a flight delay or cancellation?
Regulation EC 261/2004 specifies that passengers may receive compensation if the delay, cancellation or denied boarding was caused by an incident under the responsibility of the airline. It means that the airline will have to pay compensation unless it can prove that the disruption was caused by an extraordinary circumstance. Examples of extraordinary circumstances include adverse weather conditions, natural disasters, political unrest, a threat to the safety of the flight or passengers, a passenger falling ill, etc.
To find out more about extraordinary circumstances, please visit our extraordinary circumstances page.
Claim your compensation for you disrupted TAP Air Portugal flight
Very often, airlines make the process of claiming as complicated as possible in order to simply avoid compensating their passengers. They also overuse the argument that the disruption was caused by an extraordinary circumstance. Therefore, and more often than not, one sees passengers lose hope and accept the airline's rejection as the truth.
Fortunately, we have the adequate tools and databases to ensure that your rights are enforced and to fact-check the airlines. We will even take them to court when necessary and all of the legal costs will be covered by our 25% win-fee. If you wish so, we can take care of everything and help you enforce your rights!
If you want to maximise the probability of being compensated for your TAP Air Portugal flight delay, cancellation or overbooking, you can let a specialised service, like Flight-Delayed, take care of the whole ordeal. We will gladly help you get what is yours, all under our no win, no fee agreement.
Have you filed a claim with TAP Air Portugal but they have rejected your claim? We can still help you!
If you're uncertain if your flight delay or cancellation qualifies for compensation, once you've submitted your claim our team of experts will analyse the circumstances and assess your situation. If your claim has already been rejected by TAP Portugal, you can still submit your claim and our team will verify and fact-check the airline's arguments. Very often, they assess the situation wrongly and reject perfectly valid claims; so don't give up that easily and don't worry, we're here to help you!
TAP Portugal: Network and Punctuality
The Portuguese airline founded in 1945, operates under 106 aircraft of which currently all are of the Airbus model. Mostly, it flies using the Airbus A330 and the A320 model. The airline serves 85 destinations in 35 countries, making it one of Portugal's top serving airlines. The company's on-time performance is at 53.6% (September 2019) amongst other global airlines, meaning just over half of the air carrier's flights are delayed, possibly making you eligible for compensation.
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text:
Home BlogWeekly News 10 Bits: the Data News Hotlist
by Joshua New May 4, 2018
This week's list of data news highlights covers April 28 – May 4, 2018, and includes articles about the full launch of the United States' precision medicine initiative and a virtual scavenger hunt that teaches AI common sense.
1. Opening the Vatican's Secret Archives
Scientists at Roma Tre University in Rome have launched a project called In Codice Ratio in partnership with the Vatican Secret Archives (VSA), which maintains one of the world's largest collections of historical handwritten texts, to use AI to digitize and share VSA's collection. The VSA houses 53 miles of shelving holding works dating back 12 centuries, but hardly any of it has been made available online, making it practically useless for scholars. The scientists will use an AI system they developed to augment existing character recognition software to allow it to interpret and transcribe handwritten texts.
2. Kicking Off Precision Medicine in the United States
The U.S. National Institutes of Health (NIH) is launching open enrollment for the All of Us precision medicine initiative, which aims to compile a database of comprehensive health data from 1 million Americans to advance medical research. NIH has been piloting the initiative since 2017 and has already enrolled 16,000 people to test how to best collect health and behavioral data, including genetic data and data from wearable fitness trackers.
3. AI Can Be Your Guide for the Royal Wedding
Sky News has partnered with Amazon Web Services to use AI to identify attendees in video coverage of the wedding of Prince Harry and Meghan Markle on May 19 in real time. Viewers using the Sky News app or watching online will be able to select famous guests during the livestream and the AI system will identify them and provide background information.
4. Keeping Bullies Off Instagram
Instagram has announced that it will implement an AI system called DeepText to analyze and filter user comments that contain toxic content such as bullying, sexual harassment, and racism. DeepText relies on deep learning to interpret language contextually, which enables it to understand words or phrases that are used literally, as well as identify content, such as slurs, even if users misspell them in an attempt to bypass the filter. DeepText can automatically hide these comments and flag users that are repeat offenders.
5. Data Sharing Could Make Autonomous Cars Safer
Autonomous vehicle company Oxbotica is piloting a system for sharing data from self-driving cars with other cars and third parties, including insurance company XL Catlin, to help improve navigation and reduce potentially risky behavior. As Oxbotica cars transmit data about speed, direction, and their surroundings in real time, they alert each other about road conditions, such as whether construction work is taking place on a particular stretch of road. By sharing this data with third parties, such as insurance companies, when a car encounters a difficult situation, such as large amounts of unexpected obstacles caused by kids leaving a school, a third party could review this data and recommend ways a car could reduce risk, such as by rerouting or reducing its speed.
6. Making Airports Smarter
Singapore's Changi airport is testing a variety of different technologies, including facial recognition and connected sensors, that could help reduce travel delays and better predict travel times. The airport is testing how facial recognition could help locate travelers late for their flights to reduce delays, as well as automate immigration and bag check. Additionally, Cangi is trialing the use of sensors that monitor when planes leave the gate and take off, which has helped reduce taxiing time by 90 seconds during peak hours. Another test involves using AI to analyze wind and weather data to accurately predict flight arrival times two hours out, whereas Changi could only predict arrival times 30 minutes out using traditional methods.
7. Building an AI Scavenger Hunt
Researchers at Georgia Tech and Facebook have developed a virtual scavenger hunt challenge designed to evaluate whether an AI system can successfully use rudimentary common sense. The challenge involves asking an AI-controlled agent questions about the location of objects in a simulated home, so that over time the AI can predict where it makes sense to look for certain objects, such as by learning that cars are usually found in a garage and that it can usually access a garage by going out the house's front or back door.
8. AI Could Help Prevent Childhood Blindness Better than Doctors
Researchers from Oregon Health and Science University have developed an AI system that can detect whether a patient has retinopathy of prematurity (ROP), which can cause blindness in premature babies, with 91 percent accuracy, whereas human experts can only do so with 82 percent accuracy. Diagnosing ROP involves evaluating whether blood vessels in the back of an eye are overly dilated or malformed and requires specialized training. This disease is difficult to diagnose and can cause blindness if doctors do not detect it early. The researcher's system could help alleviate the shortage of ophthalmologists trained to diagnose ROP.
9. Performing Background Checks in Real-Time
Israeli startup Intelligo has developed background check software, called Clarity, that uses AI to automatically conduct background checks with 90 percent accuracy. Background checks are crucial for a wide variety of business applications, but are typically manual processes that can be time consuming, expensive, and inaccurate. Clarity can analyze data from social media, legal records, and other sources typically used in background checks to automate this process and identify potential red flags about a person in real-time.
10. Turning Instagram into Training Data
Facebook has developed a method for training computer vision systems on public Instagram posts that relies on user-created hashtags to provide clues about the contents of each image. Developers typically have to manually label training data for an AI system to be able to learn to recognize different objects in images, but curating large training datasets can be resource intensive. By using hashtags instead, Facebook bypassed the need to manually label the contents of images. A computer vision system Facebook trained on this data performed two percent better on a benchmarking test than any other existing system.
Image: Nan-Cheng Tsai.
5 Q's for Tom Lee, Policy Lead at Mapbox
Visualizing Segregation in the United States


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text:
Do not claim this as yours
Starting to feel his senses coming back to him, Bugsy slowly opens his eyes, and feels himself moving fast on something. He is greeted by the voice of a teenage boy who is currently right in front of him, and the boy, who addresses him by the nickname 'bug net guy', is glad that the Azalea Gymleader has come around.
Bugsy recognizes with a start that it is Gold from New Bark Town, and realizes that the boy has saved him. He wonders what has happened exactly, and Gold points up towards a four-legged creature with a golden ring around its abdomen, which is hovering high up in the sky ahead of them. Gold explains that the being is a mirage Pokemon named Arceus, and it was responsible for blasting the Ecruteak Gym into rubbles. In fact, Arceus launched its attack right at the moment he was in the middle of obtaining the information he sought from Morty.
Bugsy is curious as to what Gold wanted to learn from Morty, and Gold explains that he wishes to know the whereabouts of a man by the name of Lance. Unfortunately, the Ecruteak Gymleader only handed him a drawing he sketched out of what he saw with his distant vision ability, and did not get the chance to interpret it before Arceus interrupted their session. Gold shows Bugsy the rough sketch, which depicts a number of symbol-like creatures surrounding several statues, and the Azalea Gymleader bolts with recognition that it is no other than the Ruins of Alph.
Gold is shocked that the drawing means something to Bugsy, and Bugsy explains that it is the place where he has spent years of research on, and he will not be mistaken about this ancient village where the Unowns flitter. Gold requests to know where the Ruins of Alph is in relation to their current location, and Bugsy spots the road sign of Route 36 in front of them. He takes another glance at Arceus who is advancing south from above, and states that the ruins are exactly in the direction where the mirage Pokemon is heading. Voicing out his encouragement to Explotaro, Gold tells the Typhlosion to speed up, and continues their chase after Arceus.
A few moments later, Gold and Bugsy have arrived at the Ruins of Alph. Standing amid the stone-made huts which are lined next to a small river, Gold looks around and wonders where Lance could be. Bugsy reads Morty's drawing again, and tries to figure out which chamber it is depicting. Just then, Dragonite's Pokeball stirs in Gold's pocket, and Gold realizes that it is gesturing towards one of the stone huts. Clearly, the dragon Pokemon has detected the presence of its trainer, and Gold quickly dashes into the stone hut which it points.
Yet, as soon as he steps into the chamber, something ambushes him, and Togetaro pops out from its Pokeball to push him out of the way. Gold sees that his attacker is a Tyranitar, and spots a red-haired man sitting against the wall, his body battered and his cape torn. The man orders Tyranitar to stop attacking, and Gold soon recognizes him as the guy he saw from the hologram at Prof Oak's Science Lab. He steps forward to greet Lance, and jokingly accuses him of being a no-show at their agreed meeting place at the Pokeathlon, which took him quite a hassle to reach. Lance rationalizes that Gold must be the trainer sent by Prof. Oak, and says his apologies for standing the boy up, but explains that he was unfortunately ambushed on his way to the Pokeathlon Dome, and some skillful disguise tricks from his attacker got the best of him.
Gold grins that it was exactly what Bruno postulated, and says he has brought along his injured Dragonite which they have calmed and healed. He reaches into pocket to dig out the dragon Pokemon's Pokeball, but accidentally drops the bundle of medals which he earned at the Pokeathlon. Lance is surprised to see all five medals in Gold's possession, and the boy brags with an arrogant tone that conquering the Pokeathlon wasn't such a dire task.
Lance pauses for a moment of thought, and states that Pokedex Holders recognized by Prof. Oak are truly remarkable trainers. However, even with such skills, it is still impossible for Gold to succeed, for it takes far more than that to open up the heart of Arceus, who has already lost all hope on mankind. With that, the man turns his head to one side with a sigh, and Gold gets infuriated by the discouraging remark. He tries to protest, but Lance points towards Togetaro, and says this Togepi which Gold failed to fully bond with is the best proof of his claim. The comment causes Togetaro to widen its eyes in shock, and Gold, who is unable to find a rebuttal to the accusation, simply grunts in frustration as he tries to think of an appropriate response.
At that moment, Bugsy rushes into the chamber, and warns that Arceus is about to land outside. Gold is annoyed that a new problem presents itself before he could solve the existing one, and tells Bugsy to look after Lance while he heads out to face the deity-like Pokemon with Togetaro. Right before Togetaro leaves the room, Lance stops it in its tracks, and gives it a Shiny Stone to hold. He relents that it probably may not find the chance to use it, but wants it to have the item anyway.
Outside, golden rings of energy radiate in circles around Arceus as it hovers high above the ruins. It soon descends to the ground with a loud thump, and towers over Gold as the boy looks up to it with Explotaro and Togetaro. He keeps his gaze on the mythical creature, and calls out Aitaro, Politaro, Sutaro and Suntaro from their Pokeballs. The giant white Pokemon's eyes twinkle with an eerie light, and an energy field suddenly starts to rise from the ground to form a globe around itself and Gold.
In no time, Gold and his Pokemon are completely enveloped in the energy field with Arceus, and after banging and kicking around, he discovers that the field's boundaries would not budge, and it seems to be an alternate dimension of some kind. Left with no choice, Gold spins his feet around on the worn-out stone tiles, and takes a wary step forward. He pulls out the version VI Pokedex from his bagpack to his aid, and feels frustrated at the current situation, wondering how things have come to this.
Before him, Arceus stands proud and stares down at him with malicious eyes. Its body exudes an overwhelming royalty, and threatens to distort even the air and space around it. Gold hesitates for a moment, and orders Explotaro to unleash a Blast Burn. The flames on the volcano Pokemon's back instantly erupt into a blinding blaze, and envelop the God-like quadruped's upper torso entirely. Gold pulls down the goggles from his cap to shield his eyes from the blinding fire, and formally introduces himself to Arceus as Gold from New Bark Town. He remarks that he has originally come to help the deity, and really doesn't understand why he has ended up fighting it instead.
Shaking itself clear of Typhlosion's flames, Arceus raises its head to let out a booming roar, and delivers a Hyper Voice attack which causes Gold's entire team to all tumble back and hold their ears in agony. Gold puts on a disgruntled look, and urges his Pokemon to hold on, at least until Silver comes to join them. Suddenly, Arceus rears its head backwards, and starts to glow with an intense light.
Meanwhile, the Radio Director arrives at what is supposed to be the Ecruteak Gym with his Dusknoir. His mouth gaps open wide as he stares at the rubbles in front of him. Recalling that it has only been a few hours since Gold left for this place, he cannot believe that the entire Gym is already gone, and exclaims that the boy is truly a troublemaker. He hollers that one is definitely putting his life at stake for trying to do coverage on the boy, but decides to keep following him anyway. Shouting for Dusknoir to hurry up, the man hops back onto his car to head off, and declares that he shall do a 2-hour special just for Gold.
Back at the Ruins of Alph, Arceus generates multiple energy globes around itself, and fires them towards the sky. The globes then plummet down like a meteor shower, and Gold lets out a cry as he and Pokemon try their best to dodge and evade the powerful attack. They soon hit themselves against the energy field's boundary however, and Gold grunts that there really isn't much room to run in this confined space. Turning to Arceus, he angrily demands to know what it is trying to do, and says it is certainly not cool to imprison someone like that.
Arceus respond with a swing of its head, and fires another powerful blast onto the ground, causing an explosion which throws the boy and his team off their feet. Gold rolls to a halt as he crashes against Explotaro, and catches a hint of sorrow in Arceus's gaze. In fact, it is a sentiment that he has already picked up when he first locked eyes with the deity-like Pokemon at Ecruteak City.
Gold somersaults away from Explotaro, and states that the sad look in Arceus's eyes makes him feel the need to help. However, it is clear that Arceus has no plans to volunteer its story, and Gold must use his own ways to find out the reason behind its sadness. As if to prove his point, Arceus thrusts its foreleg forward to strike at Gold, which the boy narrowly escapes. The deity-like creature then unleashes a burst of flame from the golden ring around its abdomen, and Gold grunts in frustration as he dashes back and forth to evade the attack. Taking out his Pokedex, Gold hopes to find out something about the alpha Pokemon, and reads that it is said to emerge from an egg before it shaped the world out of nothingness.
Back at the ruins chamber where Lance is, Bugsy looks out from the entrance of the stone hut, and sees that Arceus has created a special territory to surround itself and Gold. Lance ponders for a moment, and wants to know if Bugsy has visited the data museum at the basement of the Pokeathlon Dome. The Azalea Gymleader replies that he hasn't, and Lance explains that the museum actually houses the documentations on the Pokeathlon's origins.
Long ago, on an island in a distant region, a deadly epidemic has hit the residents and their Pokemon. At that time, a trainer and his team of Pokemon have set out to find a mirage Pokemon, whom they believe could teach them the way of remedy to cure the disease. Yet, in order to reach where this mirage Pokemon was, they must go through 10 different obstacles, which could not be overcome by man or Pokemon alone.
Fortunately, the trainer and his Pokemon worked together in close collaboration, and managed to conquer the first obstacle with their equally determined souls. They were subsequently able to beat the obstacles one by one, and eventually inherited the healing ways from the mirage Pokemon. This trainer and his Pokemon were later revered as heroes by his people. In order to let their descendants remember the heroic act, the island residents invented sports that resembled the 10 obstacles the trainer and his Pokemon went through, which as time went on, evolved into the 10 Pokeathlon events of the present day.
Lance states that he initially thought if he managed to find a trainer who together with his Pokemon matches the qualities of this ancient hero, they could perhaps dissolve the deep grudge and disappointment that Arceus holds towards humans. That is the reason why he has chosen the Pokeathlon Dome as the venue to meet one of Prof. Oak's Pokedex Holders. However, it seems that even though he has found a trainer who apparently possesses the skills of this hero, the trust between this trainer and his Pokemon is still lacking.
Bugsy feels intrigued by the mirage Pokemon spoken of in the story Lance just told him, and says compared with the ferocious Arceus, he is actually more interested in a creature like that who leads one to the path of healing. Lance ponders for a moment upon at that point, and relents that perhaps he has no choice but to visit a certain place.
Shaking off his injuries, the man straightens himself up, and Bugsy wants to know where he is going. The Azalea Gymleader is surprised that he does not plan to lend his assistance in solving the current crisis, but Lance states that lending his assistance is exactly what he is going to do. With that, he sends out Dragonite, whose health has been fully restored, and takes off into the skies on the dragon Pokemon…
Thanks To Coronis For Writing this for us
453: VS Arceus II


If you get hold of a BMW V8 manual gearbox then you'll also want the E34 V8 manual flywheel and clutch. Finding a complete manual 530/540i to take the engine & box from would be ideal.
The E34 530i used a 240mm clutch, and the E34 540i used a larger 265mm clutch. Later E39 540i models went back to using the smaller 240mm design.
I decided to use a Ford V6/Cosworth pattern 240mm clutch because i didn't have a manual BMW flywheel or clutch to begin with, so i chose a clutch pattern that was universally available and had upgraded parts available. Also it fitted with spline pattern on the Ford gearbox i used.
The paddle plate i'm using doesn't have a sprung centre, and i'd read that these will judder a lot for everyday driving. The only time i've noticed the judder is when you have to feather the clutch a lot, like pulling out of a tight parking space on a steep hill or creeping in slow traffic up a steep hill. Apart from these situations it drives like a normal clutch.
A new 32x15x9 ball-bearing was fitted in the back of the crank to take the Ford input shaft. The hole in the crank is far too big for the Ford input shaft so it needs the right sized bearing to stop the end of the input shaft floating around.


I discovered that B built and painted small ( HO scale) buildings very well.
never admit to any of this.
I can use them as a guide to size the surrounding trees and other greenery.
ideas from! Oh, the possibilities! A Forced Perspective…!
find on "perspective" was "a point of view." Well, that's a start.
view of the present with the help of a forced perspective of the distant past.
needs become more painfully evident, as do our evils and wickedness.
look how many times that scenario has repeated itself in that 500 years.
Don't they document these events? Don't they see what they're doing?
Can't they learn from it??
different light. Now if I could just like what I'm seeing… but alack and alas!
and…just so the forced perspective is not an unbalanced perspective,.don't forget to spend a little time dwelling on the truly wonderful things that have occurred in those five hundred years…and the millions of gifted, humble and giving people we have been blessed to have among us…the vast majority of whom have lived honorably, working to make a honest living, raising their families to have better lives than they….starting nary a conflict or war….and many of whom have spent the blood, sweat and tears of their lives creating spiritually uplifting music, art, literature…even political opportunities that benefited millions of people they didn't even know… i.e. the founding fathers of this country. five hundred years ago the population of the world is estimated to have been 400-500 million. that is a pretty big bell curve and the extremes are way out there…not as far as today with 7 billion…but still pretty far out there. it would be quite surprising if out of that 400-500 million (or today's 7 billion) there weren't some people with evil intent, focused on power and greed. good news does not sell…so i don't expect to the news to provide a balanced perspective…but that doesn't prevent me from looking for it.
Loving the photo in your trapper hat.
My first introduction to forced perspective was a tour at Disneyland and the explanation that Walt used it in designing his Main Street buildings. Much like a movie set.
And much more enjoyable to contemplate than our church vs state situation.
I have high hopes for the upcoming generation to help set things right.


text:
Sport Coopsol fue un club de fútbol del Perú, de la ciudad de Lima, en el Departamento de Lima. Fue fundado en el año 2000, participó cuatro temporadas en Segunda División hasta su desaparición en el 2004.

Historia

El Club Telefunken 20 era un equipo originario de Huaral, provincia de Lima; que fue una sensación en la Copa Perú del 1998 llegando a las semifinales de la etapa nacional. Aunque no logró campeonar fue mérito suficiente para ascender a la Segunda División de 1999.

En la Segunda División de 1999, desempeñó una campaña regular y buscando la manera de ganar simpatía de la gente de Huaral, usó un uniforme igual al de Unión Huaral. En el año 2000, el Grupo Cooperativa Solar (Coopsol) adquirió la categoría del Club Telefunken 20, que hasta ese momento participaba en la Segunda División. Con el apoyo económico de la empresa matriz, Coopsol debutó en el torneo de ascenso ubicándose en la octava posición.

Al año siguiente, Sport Coopsol se ubicó noveno entre 16 elencos participantes. En el 2002 estuvo a punto de descender, sin embargo se ubicó en el puesto trece por encima de los descendidos Guardia Republicana, Lawn Tennis y Bella Esperanza. El año 2003 el grupo patrocinador decidió hacer una mayor inversión y conformó un mejor plantel que le permitió obtener el título de Segunda División.
Luego de mantenerse en la Segunda División, Sport Coopsol, cuya sede principal era la ciudad de Lima, efectuó una gran campaña en el torneo de 2003 pues se ubicó en el primer lugar con 55 puntos producto de 18 triunfos, un empate y cinco derrotas. Entre sus principales figuras destacaban José Carlos Fernández, Manuel Tenchy Ugaz, Wilmer Carrillo, Eddie Carazas, Giancarlo Chichizola, el capitán Víctor Anchante, Paulo Zabárbulo, el exjugador de IMI de Talara y Melgar Luis Bello y el arquero Héctor Hernández. Era dirigido por Jorge Machuca, quien reemplazó al paraguayo César Cubilla en el transcurso del torneo.

Coopsol dio la vuelta olímpica en el estadio de la Universidad Nacional de Ingeniería un 19 de octubre de 2003, tras derrotar por la mínima diferencia a Sporting Cristal B. El cuadro celeste era su máximo perseguidor, pero igual no podía ascender al ser la filial del primer equipo cervecero. El tanto triunfal lo marcó Giancarlo Chichizola.

Cuando se esperaba que Sport Coopsol regresara a la Primera División (aunque, como se mencionó, en estricto este equipo era la filial del que descendió en 2002), el presidente del club Freddy Ames decidió vender la categoría a la Universidad de San Martín de Porres, que deseaba entrar al fútbol con un equipo propio. Finalmente el año 2004 Sport Coopsol, quien ascendió a la profesional siendo DT Jorge Machuca Velásquez. Coopsol decide venderle la categoría a la Universidad San Martín de Porres, que deseaba formar su equipo de fútbol, y desaparece del mundo futbolístico.

Uniforme
Uniforme titular: Camiseta roja, pantalón azul, medias blancas.
Uniforme alternativo: Camiseta blanca, pantalón blanco, medias blancas.

Telefunken 20, de 1980's

Telefunken 20, de 1990's

Telefunken 20, de 1999

Sport Coopsol, 2000/2001

Sport Coopsol, 2002

Sport Coopsol, 2003

Estadio

Jugadores

Relacionado

Sport Coopsol de Trujillo
Deportivo Coopsol

Palmarés

Torneos nacionales
Segunda División del Perú (1): 2003
Departamental de Lima (2): 1984 y 1998

Referencias
Historia Sport Coopsol
Sport Coopsol Campeón 2003
http://dechalaca.com/hemeroteca/el-once-ideal/once-ideal-machos-para-llamarse-asi
Telefunken 20
Galería Telefunken 20
Sport Coopsol Galería
http://es-es.facebook.com/media/set/?set=a.281571505192975.91820.156567064360087&type=3

Equipos de fútbol desaparecidos de Perú
Equipos de fútbol fundados en 2000

redpajama_set_name: RedPajamaWikipedia


text:
package org.spongepowered.common.data.manipulator.immutable.item;

import com.google.common.collect.ImmutableList;
import org.spongepowered.api.data.DataContainer;
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import org.spongepowered.api.data.manipulator.immutable.item.ImmutablePagedData;
import org.spongepowered.api.data.manipulator.immutable.item.ImmutablePlainPagedData;
import org.spongepowered.api.data.manipulator.mutable.item.PagedData;
import org.spongepowered.api.data.manipulator.mutable.item.PlainPagedData;
import org.spongepowered.api.text.Text;
import org.spongepowered.common.data.manipulator.immutable.common.AbstractImmutableListData;
import org.spongepowered.common.data.manipulator.mutable.item.SpongePagedData;
import org.spongepowered.common.data.manipulator.mutable.item.SpongePlainPagedData;
import org.spongepowered.common.text.SpongeTexts;

import java.util.List;

public class ImmutableSpongePlainPagedData extends AbstractImmutableListData<String, ImmutablePlainPagedData, PlainPagedData>
        implements ImmutablePlainPagedData {

    public ImmutableSpongePlainPagedData() {
        this(ImmutableList.of(""));
    }

    public ImmutableSpongePlainPagedData(List<String> pages) {
        super(ImmutablePlainPagedData.class, pages, Keys.PLAIN_BOOK_PAGES, SpongePlainPagedData.class);
    }

    @Override
    public DataContainer toContainer() {
        return super.toContainer().set(Keys.PLAIN_BOOK_PAGES.getQuery(), this.getValue());
    }
}

redpajama_set_name: RedPajamaGithub


Review: Jacek (Mateusz Kosciukiewicz) lives in rural Poland, working on the building site near his village where a very special statue is being built. It has taken many of the locals to be employed to construct what is to be the largest Jesus Christ in the world, beating even the one in Rio de Janeiro, but this does not make Jacek a pious follower of the Christian faith as he still loves his heavy metal music, which he plays in his little red car as he speeds along the country roads. He is a happy-go-lucky sort whose love for his girlfriend Dagmara (Malgorzata Gorol) improves his life no end, but what if something unexpected happened which changed that life drastically?
If you did not know the twist in Mug, or Twarz as it was known in its original Polish, then even so you would have a sense of an ominous atmosphere no matter how full of joie de vivre its protagonist was: everyone around him, well, almost everyone, is a negative character, dwelling on the petty, the prejudiced, the bitter and angry. Not like our Jacek: he may not have a grand plan for his next few decades, but he is going to enjoy himself no matter what, or at least he is if he stays healthy. But co-writer and director Malgorzata Szumowska had other things in mind, he was to be a symbol, as much as the gigantic Christ for the Catholics of Polish society is meant to be.
But Jacek is a living person, who should matter more than a towering rendition in stone, yet somehow he does not. There were critics of this film for its depiction of the ordinary Poles as basically a bunch of bigoted morons who cling to their superstitions like a life raft, yet that was overlooking the director did not view them all like that, for Jacek was assuredly not, despite growing up among these small-minded folks he is generous of spirit and genuinely likeable. He has a perspective on life, where he doesn't take it too seriously in the faces of those who take it far too seriously to the extent of being obsessed with bringing everyone else down their miserable level.
Jacek is having none of this, he has seen what, for instance, his sister (Agnieszka Podsiadlik) has been through in her marriage, chained to one of the biggest boors around who will never be mistaken for a ray of sunshine, seeing the worst in everyone and never more satisfied than when he has pointed that out. But Jacek has Dagmara, who affirms his force of positivity and has you certain he has a soulmate who will complete him, which sounds corny but applies here... so what about that ominous feeling that you have been noting throughout the first act? You would be well advised to pay attention to that, for it as if the Christ statue has been surveying the landscape for miles around and spotted someone who doesn't need his piety and is dead set on punishing him for blithely flaunting his freedom.
Here is where Jacek meets his potential doom, and all while working on the construction of a statue it was clear the film had feelings about that were at best ambivalent and may even have gone as far as thoroughly sickened by when there were so many worthier causes the money spent on this could have gone towards. The Catholic Church was in for a kicking in Mug, implying that its followers were content with being endlessly judged and belittled for a place in Heaven that may not even exist, all while well aware that a little film from Poland was not going to change any minds: there was a playing to the gallery about this, not seeking to let the scales fall from the eyes of billions, to use a Biblical analogy. With the superstition and superficiality abounding, and only lip service paid to charity, we can be glad Jacek at least gets through his difficulties, a changed man, but retaining his belief in himself and despite it all, finding the goodness in others that even the Church may not acknowledge. Music by Adam Walicki.
This review has been viewed 110 time(s).


So, which model of step lift should you choose? To provide a effective overview - stair lift models generally fall into two broad categories, straight and curved. Straight models are built for stairs with no bends or half-landings. They are usually better to install and cost less than curved variants. If your staircase has bends, corners or half-landings, you'll need a curved stairlift. Your stairlift rails will need to be custom-built to ensure a good in shape to your stairs. This level of customization means that curved types are more expensive to purchase. Reconditioned products can be a cheaper alternative to cutting edge stair lifts but may well not contain all the features of the modern versions. Re-conditioned models are fully refurbished used numbers and as a result may not be as feature-packed as totally new models. Only ask the manufacturer for a full feature list.
Stlfamilylife - Laminate flooring transition and trim quick. Quick step offers an array of transition and trim for your laminate floor project that are easy to install and help protect your floor from wear laminate provides a smooth transition from a quick o step � floor to a floor of a lower height, such as tile or a resiliant flooring. Quickostep� laminate flooring transition and trim. Quickostep�'s multifunctional floor molding and trim are easy to install and tie your flooring together with your room to look beautiful laminate hardwood creates a transition from quick o step � floor to carpet. Cutting laminate flooring trim, installing the transition. The next step is cutting laminate flooring trim so we can install it in the track we installed cutting laminate flooring trim to fit in the doorway when cutting the laminate flooring trim i want the transition to be as close to each side of the door jamb as possible. Flooring101 avoid these transition install mistakes. Flooring 101 home waterproof flooring tips avoid these transition install mistakes search transitions and trim complement the flooring and provide a safe durable way to create expansion contraction space between areas, and lead to other existing floors in the home. Laminate flooring transition and trim pinterest. Quick step offers an array of transition and trim for your laminate floor project that are easy to install and help protect your floor from wear laminate flooring flooring ideas hardwood floors quick step flooring kitchen and bath remodeling mudroom family room basement wood floors plus. Laminate flooring trim and transition installation. Quick guide; calculate area needed for the correct amount of laminate flooring calculating how much and what types of laminate flooring trim and transition molds you need floor preparation, not always the fun part but it has to be done how to measure for baseboard or quarter round; installing laminate at sliding glass doors. Quick step incizo 5 in 1 molding set best laminate. Carpet reducer transition profile creates a transition from quick step floor to carpet stair nose finishes quick step flooring on stairs this 5 in 1 cannot be used as a flush mount stair nose without the proper mounting bracket which is sold separately. Moldings guide floor molding and trim best laminate. Moldings guide floor molding and trim it's an accomplishment to finish a flooring installation, but there's one more step to completing a new floor the moldings and trim! the floor moldings provide coverage over expansion gaps and create a finished look around the edges of a room, both on the wall and transitioning to other rooms. Laminate moulding & trim laminate flooring the home depot. T molding is used to transition two floors of t molding is used to transition two floors of the same height typically installed between rooms or in entryways this molding will provide a seamless look when transitioning between flooring surfaces and in doorways. Transition strips laminate flooring the home depot. Shop our selection of transition strips, laminate flooring in the flooring department at the home depot.


text:
Candy Shell Life
No Good Excuse
Fighting FA
My Darling Disability
Little Victories
A Practical Guide to Life with FA
What is FA?
Living with FA
Inheritance of FA
Cardiomyopathy and FA
Dysarthria in FA
Dysphagia in FA
Diabetes in FA
CTI-1601
Equitasi
Actimmune (Interferon gamma)
CAT-4001
Epicatechin
EPI-743 (Vatiquinone)
RTA 408 (omaveloxolone)
TAT-Frataxin
Histone Deacetylase Inhibitors (HDACi)
Nicotinamide (Vitamin B3)
STS-E412 and STS-E424
VY-FXN01
RNA-based approach
Study Describes Rare Genetic Cases of Friedreich's Ataxia in Brazil
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Friedreich's ataxia caused by GAA repeat expansion and point mutations — a rare origin of the disease — is present in the Brazilian population and should be considered for diagnostic testing and genetic counseling in the country, a study shows.
The study, "Frequency and Genetic Profile of Compound Heterozygous Friedreich's Ataxia Patients-the Brazilian Experience" was published in the journal Cerebellum.
Friedreich's ataxia (FA) is caused by an abnormal DNA expansion within the FXN gene, which gives instructions for the production of frataxin protein.
In the FXN gene, there is a region where three nucleotides (the building blocks of DNA) termed GAA are normally repeated in healthy people anywhere from five to 33 times.
Most people with FA (96%) have an increased number of these repeats, ranging from 66 repeats to more than 1,000 repeats in both copies of the FXN gene — the one inherited from the father and the one inherited from the mother. This is called a homozygous GAA expansion.
The remaining patients have a GAA expansion in one copy and point mutation — a mutation affecting only one or very few nucleotides — in the other, a type of genetic profile known as compound heterozygous. Little is known about these patients, especially outside Europe and North America.
So in this study, researchers from the University of Campinas in Brazil sought to determine the frequency and genetic profile of these patients in their country.
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They recruited all patients with ataxia registered at three Brazilian national reference centers — a total of 143 patients from 128 unrelated families. From this group, they selected those who carried GAA expansion in at least one of the gene copies, who were subjected to further genetic testing.
Of the 143 patients examined, five had a single expanded copy, which translates into a frequency of 3.93%.
Researchers were able to identify point mutations in three of these five — two had the c.157delC variant, which was already described, whereas one had a novel variant termed c.482+1G>T.
"These results indicate that FXN point mutations are rare, but exist in Brazilian patients with [Friedreich's ataxia], " the researchers said.
"The proportion of possible or confirmed point/insertion/deletion mutations at GAA among the present Brazilian FRDA subjects (3.93%) was similar to the figures found elsewhere, of around 4% among FRDA subjects of European ancestry, " they added.
The researchers stress that the findings have "obvious implications for diagnostic testing and genetic counseling" in the country.
They also emphasize that larger studies will be important for investigating potential founder mutations — a mutation that appears in the DNA of one or more individuals who are ancestors of a certain population — or variants specific to certain ethnic groups, which would be important for proper counseling.
Tagged Brazil, compound heterozygous, GAA repeat expansion, inheritance, point mutation.
Previous: Living By the Book: I Can Pursue the Joy of Reading in a Wheelchair
Next:4 Solutions to Beat the Heat with FA Symptoms in Mind
The Bare Minimum: Don't Stop There
I Learned a Big Lesson from the Tiniest of People
Stand Against Negative Comments and Use Them to Build Your Strength
Natural DNA-Replication Mechanism May Help Fix Genetic Defect in FA, Study Suggests
The People We Surround Ourselves With Matter
Friedreich's Ataxia Can Emerge After Age 50, Case Study Shows
How I Realized I Was Ready to Transition to the Next Assistive Device
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Ruined reputation just a few clicks away
Joel Sherman
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ANAHEIM, Calif. — In this age, a stellar reputation built over years can turn to spit in a few clicks of a mouse.
It is the viral virus of our times; the swine flu of modern technology. Newspapers may be reeling, but there still is something to be said for the institutional cautiousness that has generally been part of their history. Multiple sources and a line of editors and actual deadlines might sound trite when "information" now travels as fast as you can type it. But a lot of mistakes have been prevented over the years with that system.
At some point yesterday morning, a video began circulating of Mariano Rivera spitting in the general direction of a baseball he was holding during Game 3 of the ALCS. Over the next few hours, Major League Baseball felt compelled to investigate the available video and still photos of the incident. By early in the afternoon, I was the first to reveal, on the Post's Web site, that the Commissioner's Office had "found no evidence that Rivera spit on the ball."
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In the few hours in between film clip posting and absolution by MLB, every save in Rivera's illustrious career was put in question. There was a lot of supposition on why Rivera has been able to stay elite with just a one-pitch repertoire.
Suddenly, we knew what the secret sauce was on the most fiendish cutter in baseball history. Now, I am not here to find Rivera not guilty. If the steroid phase of our life has taught us nothing else it is never to say never about anything.
But you could put me down on the list of those extremely doubtful Rivera cheated at that moment in Game 3, and pretty dubious if he has doctored balls throughout his career.
Think about it this way: How many hours has Rivera been on camera in his career? This guy is more a staple of October TV than the Columbus Day Parade. And it is now, 15 years into his career, that he is getting a Zapruder moment?
When there is even a hint that a guy is cheating there is buzz in the industry about it. Three pretty high-level pitchers of the past quarter century are constantly speculated about doctoring balls within the confines of the game. Yet I have never previously heard a peep on Rivera. Considering the brinksmanship between the Yankees and Red Sox, can you imagine how quickly the Red Sox would disseminate even dubious gossip on Rivera if there was some about him fiddling with the ball? Yet nothing.
"If you followed my career, it would mean that I would have had to have a lot of spit," Rivera said.
Rivera actually was cheery when discussing this with reporters. He insisted that if anyone in a group of about 15 found direct video evidence he spit on the ball during the questioned sequence in Game 3, then he would charter a plane and take the whole group to dinner anyplace in the world. But if further video from the incident from another angle showed that he simply spit — as he does constantly when he plays — then the group had to wine and dine him.
Johnny Damon thought the charge was nonsense and the cutter is all about genetics since "his son's ball cuts" when Damon plays catch with Jafet Rivera. Joe Girardi staked his reputation that a pitcher he has caught and managed does not cheat, and so did pretty much everyone who has played with or coached him. It sounds like a
pretty big conspiracy if everyone is in on this big lie. "Don't waste your time guys," Rivera said. "I don't do those things."
It would seem pretty dumb to start now, spitting from an arm's distance in full view of umpires, opponents and the nation. But that projectile launched several thousand video hits. And in this age, Rivera was guilty in a few clicks of the mouse.
We need to slow down.
joel.sherman@nypost.com
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