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Home Neurology New Drug Targets for Childhood Cancer Neuroblastoma Identified
New Drug Targets for Childhood Cancer Neuroblastoma Identified
Summary: Researchers discovered all neuroblastomas arise from a single type of embryonic cell called sympathoblasts. The findings could lead to new avenues of treatment for the aggressive childhood cancer.
Source: Wellcome Trust Sanger Institute
The largest single cell study to date of the childhood cancer, neuroblastoma, has answered important questions about the genesis of the disease. The researchers from the Wellcome Sanger Institute, Great Ormond Street Hospital (GOSH) and the Princess Máxima Center for Pediatric Oncology, discovered that all neuroblastomas arise from a single type of embryonic cell called sympathoblasts.
The study, published today (5 February 2021) in Science Advances, sought to understand why neuroblastomas range in severity, with some easy to treat and others having relatively low five-year survival rates. The fact that all neuroblastomas arise from sympathoblasts makes them an attractive drug target, because these cells exist only in the tumour after the child is born.
Neuroblastoma is a rare cancer that generally affects children under five years old. It begins in the abdomen, usually in the adrenal glands – hormone-producing glands above the kidneys. Neuroblastoma is remarkable in that its severity can vary greatly between individuals. In some children the cancer will disappear without treatment, whereas in others the cancer is relentless. The five-year survival rate for neuroblastoma is one of the lowest of all childhood cancers.
This varied outlook prompted the researchers to ask whether the range of severity could be caused by neuroblastomas arising from different cell types at different stages of the child's development in the womb. This was made possible by the advent of single cell mRNA sequencing, a high-resolution technology that can identify different cell types present in a tissue according to the genes expressed by individual cells.
In this study, gene expression of 19,723 cancer cells was analysed and compared to a reference of 57,972 developmental adrenal cells in the hope of identifying the cell types from which neuroblastomas arise and to find novel treatment targets.
Dr Jan Molenaar, a senior author of the study from the Princess Máxima Center for Pediatric Oncology in the Netherlands, said: "What is most striking about our findings is that despite the great diversity of clinical behaviour of neuroblastoma, there is an overarching neuroblastoma cell type that is found in all patients. The identification of sympathoblasts as the root of all neuroblastoma is an important step towards understanding how the disease develops and, hopefully, how we can treat it."
Currently, many cancer treatments cause serious side effects for the patient. But in recent years, technological advances have sped up drug development by allowing researchers to identify differences between the biological processes, such as the expression of a particular gene, within healthy human cells and those within cancerous ones. These differences can be exploited to attack cancer cells without affecting the patient's healthy cells.
Neuroblastoma is a rare cancer that generally affects children under five years old. Image is in the public domain
The presence of sympathoblasts, a developmental cell type not normally found in children after they are born, makes it a promising drug target for the treatment of neuroblastoma.
Dr Karin Straathof, a senior author of the study from Great Ormond Street Hospital, said: "Neuroblastoma is an unusual cancer in that some tumours resolve without intervention, yet the disease still has one of the lowest five-year survival rates of any childhood cancer. This study fills important gaps in our knowledge of what neuroblastoma cells are and revealed novel treatment targets. My hope is that new, less intrusive therapies can be developed by targeting sympathoblasts, a developmental cell type that exists only in neuroblastoma tumours after a child is born."
As well as facilitating the discovery of sympathoblasts as the root of neuroblastoma, the single-cell reference map of the developmental adrenal gland will also contribute to the Human Cell Atlas project**. The project aims to create comprehensive reference maps of all types of human cells – the fundamental units of life – as a basis for understanding human health and diagnosing, monitoring, and treating disease.
Dr Sam Behjati, a senior author of the study from the Wellcome Sanger Institute and Cambridge University Hospitals, said: "Our study shows the power of looking at individual childhood cancer cells in revealing not just one, but a plethora of novel treatment ideas. This raises the exciting prospect that a single cell atlas of all types of paediatric tumours may transform our understanding of childhood cancer."
About this cancer research news
Contact: Matthew Midgley – Wellcome Trust Sanger Institute
Original Research: The study will appear in Science Advances
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Home » POLITICS » BAYELSA 2019: APC CANDID ATE, LYON, PROMISES TO PROTECT BAYELSA CRUDE OIL WEALTH FOR DEVELOPMENT
BAYELSA 2019: APC CANDID ATE, LYON, PROMISES TO PROTECT BAYELSA CRUDE OIL WEALTH FOR DEVELOPMENT
Photo Caption: Candidate of the APC, Chief David Lyon (middle); Senator Biobarakuma Degi-Eremienyo (Left), Deputy Governorship Candidate and Hon. Jothan Amos (Right), State Chairman of APC Bayelsa in Ekeremor Town on Saturday during the APC Governorship Campaign Rally
The governorship candidate of the All Progressives Congress (APC), Chief David Lyon, has called for stronger collaboration between government, security agencies and local communities to protect and judiciously use the crude oil wealth for the growth and development of the people.
According to Lyon who is contesting to succeed the incumbent governor, Hon. Henry Seriake Dickson, in the forthcoming November 16 governorship election, the tripod collaboration would help foster speedy development of the oil-rich Niger Delta state.
Addressing a mammoth crowd that received him at Egbemo-Angalabiri Community in Ekeremor Local Government Council, Lyon said Bayelsans still live in penury because the Dickson-led administration failed to protect and invest the common wealth of the people on profit generating projects, thereby causing the people to live from hand to mouth.
He observed that the level of development in the communities does not reflect the true nature of the contributions they put into the wealth and growth of Nigeria as oil producing areas.
He promised that when elected into office, protecting the crude oil wealth of the state from activities of pipeline vandals and crude oil thieves, a phenomenon he said has exposed the Bayelsa State to severe environmental degradation would top the list of his priorities.
Explaining further when his campaign team visited Peretorugbene and Toru-Ndoro Communities, Lyon promised to ensure that all local communities are captured in the Global Memorandum of Understanding (GMoU) of multinational oil corporations operating in the area.
He said whilst he served as youth leader of his community, Olugbobiri in Southern Ijaw LGA, in 1995, he was the first youth leader to sign a GMoU with a multinational oil corporation to secure contracts and jobs for young people, saying leadership of youth groups across the state can take a queue from him.
He declared that only when job opportunities are created to ensure that young people are self reliant that the crude oil resources of Nigeria can be safe. Lyon said this had become more imperative in order to sustain peace and stability of the state, and above all prepare a better and prosperous future of generation of Bayelsans yet unborn.
He revealed that while he is traversing communities to seek the support of the electorate in a responsible manner, his main aim is to also use the opportunity to meet and find out the teething challenges of the people ahead of the governorship poll.
Reiterating his commitment to develop the state when elected as governor, Lyon said he was not only overwhelmed by the love Ekeremor people have demonstrated towards him and the APC, but that he is also marveled by the level of preparedness of the people of the area to exercise and protect their franchise for the APC.
Interacting with the chiefs and people of the various communities, the APC candidate thanked them for their show of courage as flood continues to ravage many communities in Ekeremor, adding that he has no doubt that the people would give his party bloc votes with same courage come 16 November.
While assuring them of his readiness to impact more on their lives, immediately after being sworn in as governor, Lyon promised to complete the Sagbama-Ekeremor Road and commence work at the abandoned Agge Seaport project which he said has the capacity to provide employment for thousands of Bayelsans.
He further said, "as an oil producing communities, you deserve more than the hardship the state government has exposed you to. I understand your condition because my community suffers the same fate. In other words, I am on the same page with you in this struggle.
"If we live in a state where only the right people are elected into office, communities like yours should be enjoying better roads, schools, health facilities and potable water. This time I expect you to do the right thing by voting for the APC to ensure that we change the narrative.
"When I become governor, I would create more jobs for your people, I would lin
k your communities with the outside world through roads, I would build befitting hospitals for you, I would provide better and sustainable educational system for your children. The time to protect and spend our crude oil wealth judiciously has come."
Receiving 150 defectors from the Peoples Democratic Party (PDP) into the APC at Ekeremor Town, the chairman of APC in the state, Hon. Jothan Amos, said that the mood in the state shows that the people are fed up with the PDP-led government.
In all the communities visited, the people lauded him for employing thousands of youths through his oil and gas surveillance contract, and assured him of their preparedness to work for the victory of APC in the forthcoming election.
People from communities in the area endorsed the APC as the campaign tour climaxed with a mega rally in Aleibiri community, home town of former speaker and deputy governor, Rt. Hon. Peremobowei Ebebi, where a humongous crowd gathered to cheer and receive the campaign team despite the rains.
Speaking at the rally, Ebebi said David Lyon has given youths of the area employment opportunities and that he is confident that when Lyon becomes governor the rate of unemployment in the area would drop.
"I know David Lyon very well. He is a proven leader that has empowered and employed our youths with his position as pipeline surveillance contractor. A man with that kind of track record, I am sure would do far better if he becomes governor of the state.
"For the last seven and half years we supported the PDP-led government, what did we gain? They said they are constructing road to Ekeremor, that road is still far from complete, and in five months they would be leaving office. What then can we say is our benefit?
The campaign team visited Egbemo-Angalabiri, Peretorugbene, Isampou,Toru-Ndoro, Aleibiri and Ekeremor where monarchs and chiefs gave the APC campaign team their blessings and support.

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Guelqwen[iS] (#4) defeated ilyich[as] (#5) on "Garden of War" at 20:06:00 on 04/02/2019.
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Guelqwen[iS] (#5 → #4) defeated ilyich[as] (#4 → #5) on "Garden of War" at 19:36:50 on 04/02/2019.
ilyich[as] (#4) defeated Guelqwen[iS] (#5) on "Garden of War" at 19:24:20 on 04/02/2019.
Guelqwen[iS] (#6 → #5) defeated ilyich[as] (#4) on "Garden of War" at 18:25:42 on 04/02/2019.
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Amazon's 7-inch Coyote tablet coming October?
Amazon's rumoured 7-inch tablet, the so-called Coyote is due to start shipping in October this year. According to a report by Digitimes, Quanta Computer which handles production of the BlackBerry Playbook, is rolling the Amazon tablet out of the forges with the first lot due in about a month's time.
The bigger 10.1-inch tablet, called Hollywood, will be handled by Foxconn, who produced the iPad 2 and also produces the Kindle e-book reader for the shopping giant. Production for the bigger tablet is slated to begin early next year.
Little else is known about the tablets, other than it's an almost dead cert that they'll run on Android.
Amazon has launched its own Kindle, MP3 and Shopping apps for Android and even it's own Appstore. The currently US-only Amazon Appstore sells Android apps, sometimes for cheaper than what they're priced at in the Android Market. Amazon has also nabbed Android exclusives, as it did with Angry Birds Rio.
Amazon competes with Apple on pretty much every front – ebooks, music, apps – and so selling a range of devices tying all these services together seems like a logical step.
Its rumoured that the 7-inch Coyote will be powered by Nvidia's Tegra 2 dual core chip, while the next-gen Hollywood will feature the quad-core Tegra 3/Kal-El CPU. We've asked Amazon for a comment and we're waiting to hear back.
Source: Digitimes


The alternative finance provider Platform Black has appointed Caroline Langron as its new Managing Director.
The platform, which allows businesses to auction their outstanding invoices online to raise funds, has advanced more than £80 million to British SMEs since its launch in 2012.
Ms Langron, who was a Managing Director at Bibby Financial Services for 10 years and has three decades of experience in invoice finance, has been brought in to lead the consolidation of Platform Black's extraordinary early growth.
"Platform Black's invoice trading model has made it hugely popular both with businesses seeking flexible finance and investors seeking strong returns.
"The business has evolved from a technology-led alternative finance platform to become a significant source of working capital for British businesses. In its first month of operation in 2012 it advanced just £65,000 – it now provides several million a month.
Ms Langron takes the Platform Black reins from Colin Levins, who has stepped down as CEO but remains a shareholder in the company. His co-founder Louise Beaumont has also taken a step back, to join GLI Finance – the AIM-listed finance provider that is a major shareholder in Platform Black. Platform Black's Chairman remains David Robertson.


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Pharrell Williams Announces His First Foray Into Real Estate
The megaproducer and entrepreneur collaborated with two Toronto-based developers on a residential project set to open in 2020
Pharrell Williams announced the news at a press conference in Toronto's Yonge-Dundas Square on November 5. Photo: Steven Ferdman/Getty Images
Pharrell Williams is a multihyphenate who knows no bounds. Over the past year, the Grammy Award winner worked with Reserve Properties and Westdale Properties, two top developers in Toronto, to dream up untitled, a residential property that is set to launch in early 2020. The project will take the form of two residential towers with a joint podium, boasting 750 housing units and 30,000 square feet of amenity space.
The concept? Creating a new style of residential living that pays particular attention to what makes a space universal. "The thinking and philosophy that ended up governing the whole process was less about adding items and instead focusing on reducing and stripping away to get us to the essential core elements of the design," Shane Fenton, chief operating officer of Reserve Properties, said in a press release. "Instead of dictating a lifestyle onto our purchasers and residents, we aimed to create harmonious spaces that could serve as the backdrop to their lives. That lens was applied throughout the entire building until we ended up with something that felt both timeless and singular."
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Williams's involvement in the project included offering input on the overall vision, the materials used for the buildings, the interior layout, and even the furnishing choices. The "Happy" singer commended the team he worked with for its "collective willingness to be open, to be pushed, to be prodded and poked, to get to that uncomfortable place of question mark, and to find out what was on the other side."
On Tuesday, Williams announced the project by sharing a video on his Instagram account (above) that was simultaneously broadcast on big screens at Toronto's Yonge-Dundas Square. The clip shows him standing before an all-white backdrop, pontificating about the freedom that comes from living without the restrictions of a name.
"To live your life untitled means not having to live up to something or perform beyond a standard," Williams said in a release. "For the standard to literally just be this beautiful matrix that allows people to create their own world. How could we as designers ensure the essentials were really thought out and expertly crafted, but delivered in a way that left everything else up to the imagination of the person occupying the space?"
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What is a Grimoire? In its simplest form, it's a notebook full of magic spells.
It's where a wizard keeps his most precious knowledge: spells he's learned and gathered over the years; snippets, incantations, assorted poems and sketches. It's where he goes when he's trying to solve a problem, brush up on an old technique, or document his attempts to learn something new.
"If you have the name of a spirit, you have power over it".


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Opinion | America has 51 states
Photo courtesy of Ann Loikow/Wikimedia Commons
People advocating for the statehood of Washington D.C. during an Independence Parade on July 4, 2011. Assistant Opinions Editor Talia Duffy argues that the District of Columbia should be considered the 51st state with how much they have contributed to the government.
By Talia Duffy, Assistant Opinions Editor
In the 1760s, when British rule dominated the streets of the American colonies, prospective revolutionaries yearned for "no taxation without representation." It became a rallying cry during the revolutionary war, and eventually, it was cemented into the curriculum of fifth grade history classes across the country.
But each time that phrase is repeated, it is a lie.
Today, there are over 700,000 American citizens who are deprived of representation in Congress. They are the residents of Washington, D.C. They've been fighting for statehood for over 200 years — and yes, they still pay taxes. In fact, the district meets nearly every quality and requirement of a U.S. state, but it is deprived of many essential privileges.
In 2020, the district contributed $125.8 trillion to the nation's GDP. That's more than 16 states, including Mississippi and West Virginia. But these contributions are not reciprocated; Washington's status as a federal district means its residents have no control over their own local budget or funding.
This unbalanced relationship extends beyond money. The residents of Washington fulfill the obligations of jury duty and military service like all other Americans, yet they have little power in the federal government.
As of 1961, Washington residents can vote for president. But they have no senators, and their sole representative, Eleanor Holmes Norton, can hardly be called a representative at all: She has no vote.
Further, any law passed by the Council — Washington's version of a state legislature — is reviewed by Congress before it is enacted. And with a power that seems like something straight out of a young adult dystopian novel, Congress can choose to absolve Washington's entire local government on a whim.
This kind of tight control over local government is completely un-American. Washington's residents must rely on Congress to make decisions for them; they are forced to succumb to federal sovereignty in a way no other American citizen has to.
Most people who are uneducated on the subject balk at the idea of a fifty-first state. "Fifty is a nice number," they say. Maybe so, but equality is nicer. "Washington is too tiny to be a state," they say. But actually, it's not — more people live in the district than in Vermont and Wyoming.
Any real investigation in the matter will result only in confusion as to why the American flag is missing its fifty-first star. And this year, that star was almost added. Almost.
Recently, an act to convert the district into the fifty-first state passed in the House of Representatives. However the vote fell completely along party lines — all in favor were Democrats, and all against were Republicans — so the possibility of the bill making it to the Senate is very unlikely.
So what's the real reason for this great divide? The answer isn't that complicated. In fact, it boils down to one of the only constants in American society: racism. Not surprising, right?
If Washington became a state, it would be the only one with a black plurality at 46.31%. To give the district voting power in Congress — especially in the Senate, where party control often teeters on the edge of one or two votes — would be to give over 300,000 Black Americans a voice.
And since Black voters — and Washington residents in general — typically support the Democratic party, Republicans will do everything in their power to stop that from happening, all the while spewing excuses about defending the constitution or respecting the intentions of the Founding Fathers.
In reality, they just can't stand the thought of losing their occasional hold on the political system. But that's the thing about voting: You can't pick and choose who gets to do it. If the 700,000 majority white Republicans in Montana have two senate votes and a real representative, then the 700,000 majority black Democrats in Washington should, too.
Ironically, the Founding Fathers that Republicans so valiantly defend by blocking Washington's statehood once had something to say on the topic:
"That to secure these rights, Governments are instituted among Men, deriving their just powers from the consent of the governed …"
Without the 51st state, our democratic government does not truly operate with the consent of the governed.
So we can hardly call ourselves a democracy at all.
Talia is a freshman in Media.


The Altos de Chavón School of Design offers several options of financial aid thanks to alliances with different Dominican entities which provide funding support, as well as a scholarship program supported by the Altos de Chavón Cultural Center Foundation.
FUNDAPEC offers student loans that promote and aid the access to Chavón's different programs of study. Candidates must request information and fulfil the necessary steps during their admissions process at the school.
Banco Ademi offers student loans for applicants to the two-year college level program in Visual Communications. It grants the total or partial amount of tuition and seeks to facilitate a candidate's admission, permanence and culmination of his/her studies in the country.
The Banco del Progreso offers the service of "Crédito Diferido" as a method of funding the Two-Year College Level Program and Special Programs. This credit line grants customers a payment plan of up to 48 instalments.
The Altos de Chavón Cultural Center Foundation offers scholarships for candidates of the Two-Year College Level Program that do not have the resources to fund their program. All applicants for admission to the two-year college level program may submit an application for a scholarship. The Office of Financial Aid awards scholarships to new students according to their artistic abilities and economic need. For students already enrolled, they are granted according to academic achievement and participation in class.
Applicants for financial aid must complete, sign, and complete and submit the Application for a Scholarship from the Altos de Chavón Cultural Center Foundation. They must present certification from the Dominican Dirección General de Impuestos Internos (or, for foreign applicants, the income tax office statement issued by their government) documents that verify their family's income and provide evidence as to whether they and/or their parents are presenting a sworn declaration of income.
Applications are reviewed by the Office of Financial Aid according to criteria that determine applicants' need and their eligibility for the types of aid provided by The School of Design. Students will be notified before the beginning of the semester. Unless otherwise specified, scholarships are bestowed upon for one year, and a new application must be submitted for each academic year. Applicants who do not receive aid for their first year of study may request it for the second year. First-year students must maintain a satisfactory academic average in order to be considered for financial aid the second year.


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Turkish pianist tells government not to fear artists
"Dont be afraid of art and artists. We are not a military force. We are just musicians, actors, dancers, humans, ordinary people," said pianist Fazl Say in his open letter. (File Photo: AFP)
The culture ministry rejected the censorship claims and dismissed the musicians letter as a "publicity stunt"
AFP, Istanbul
Published: 23 October ,2014: 12:00 AM GST Updated: 20 May ,2020: 02:54 PM GST
World-renowned Turkish pianist Fazil Say appealed to the government on Thursday not to be "afraid" of artists after he claimed that his works were removed from a state-funded orchestras repertoire.
The 44-year-old virtuoso, who has had many run-ins with the authorities, wrote an open letter to the government in which he denounced a "crackdown" on artists.
Say, a strong opponent of the Islamic-rooted government, said his works had been removed from the Presidential Symphony Orchestra programme for the upcoming season.
"Change your oppressive attitude that sparks outrage and confusion in the whole world," Say said in the letter published in the local media.
"The world condemns this oppression... Stop being destructive." he added.
"Dont be afraid of art and artists. We are not a military force. We are just musicians, actors, dancers, humans, ordinary people."
The culture ministry rejected the censorship claims and dismissed the musicians letter as a "publicity stunt".
"We are following with worry the reports and statements aimed at creating an impression that there is censorship on art in our country and blowing the whistle on Turkey to other countries," the ministry said in a statement.
"There is no censorship of the musician or his works at all. His musical pieces have not been removed," it said, adding that one of the musicians works had been included in the repertoire.
"These statements should be dismissed as a publicity stunt and attempts to mislead the public."
Say, an atheist, has often criticized the ruling Justice and Development Party (AKP), accusing it of having a secret agenda to promote conservative values in Turkey.
The pianist, who has played with the philharmonic orchestras of Berlin, New York, Tokyo and Israel, was handed a 10-month suspended jail term last year over Twitter posts deemed religiously offensive.
fazil say
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A 'UK Local Information Pack' will be introduced on the 5 June 2019 to support the set-up of NHS / HSC research in the UK.
The 'UK Local Information Pack' is the set of documents that NHS / HSC organisations use to formally start preparing to deliver the study. You can find more information here, including what comprises the pack. All researchers wishing to set-up their study at an NHS/HSC site from 5 June, will need to be aware of this change.
Researchers and research teams may be aware of a document called the 'Statement of Activities' – this is essentially a document that allows the sponsor to make clear to the research site, what activities will be undertaken locally. The document can also act as the agreement between the sponsor and site. Researchers setting up their study before 5 June should continue to use this document.
From 5 June the Statement of Activities will be replaced by a document called the 'Organisation Information Document'. For non-commercially sponsored studies, that are not clinical trials or clinical investigations, the 'Organisation Information Document' should be used as the agreement between sponsor and participating NHS / HSC organisation.
Another feature of the UK Local Information Pack is the inclusion of a delegation log template, which is intended to be used at participating NHS / HSC organisations. This will allow NHS/HSC organisations to locally record who will be working on the study and who is authorised to undertake study tasks.
For non-commercially sponsored studies studies an IRAS Schedule of Events or a SoECAT will be a part of the IRAS Form submission and is used in the UK Local Information Pack as a way of providing clarity to participating NHS / HSC organisations on the cost attributions associated with a study.
Guidance on the use of the UK Local Information Pack has now been published in the Site Specific page of IRAS Help to help applicants get ready for the change.
If you are making an IRAS Form submission or planning to set up research in an NHS / HSC organisation from 5 June 2019 please read the transition guidance so that you prepare the correct materials.
If you have any queries regarding any of the information provided above, or would like some guidance with regard to implementing your research in a healthcare setting – please get in touch with BU's Research Ethics team.
You can also take a look at the Clinical Governance blog for documents, links and training opportunities.
Involving patients and/or the public in your clinical research is a great way to ensure that your study is designed and set-up in a way that will be attractive to participants. By carrying out PPI (patient and public involvement) you can also ensure that your research will be of benefit, not only to individuals but also the wider population and healthcare in general.
In 2018 the Health Research Authority (HRA) released guidance to help applicants better identify where they have involved the public in their research applications, and the difference that it made to their studies.
In addition, in January of this year two HRA blog posts were advertised, following the journey of a Research Fellow at the University of Surrey, who conducted PPI for her research project. The first and second posts can be found on the HRA website alongside other news items.
The HRA have just released the third blog post in which they talk to one of the lay Research Ethics Committee (REC) members who sat on the panel that reviewed the fellow's study. The post explores the Committee member's views on how public involvement benefited the research application. You can find it here.
Remember that support is on offer at BU if you are thinking of introducing your research ideas into the NHS, social care or healthcare institutions – email the Research Ethics mailbox, and take a look at the Clinical Governance blog.


Must you carry your licence at all times when driving?
As the holder of any class of driver licence, are you required to carry your licence at all times when driving? As the holder of any class of driver licence, are you required to carry your licence at all times when driving?
You must carry your licence at all times when driving, regardless of the type of licence.
What is the fine for not carrying your driver licence?
You must carry your driving licence at all times with your when you are driving.
According to government documents the current fine is $55, although you are more likely to be asked to visit a police station within 72 hours to prove that you are a licenced driver.
Fines are set out in the document Land Transport (Offences and Penalties) Regulations 1999.
As your licence is a valid form of photo identification it's not advisable to leave it unattended in your vehicle. If someone breaks in and steals it then not only will you have to pay for a replacement licence, but there's a risk that someone might fraudulently use the licence, or use information on the licence to identify you in other ways.
Carry your licence on you rather than leaving it.


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Lucius Varius Ambibulus (full name: Quintus Planius Sardus Lucius Varius Ambibulus), was a Roman senator of the 2nd century AD who occupied a number of offices in the imperial service, as well as serving as suffect consul in either 132 or 133.

His cognomen "Ambibulus" was described by Ronald Syme as "peculiar and uncommon"; he could only count five examples of its use in inscriptions found at Rome, and one more in North Africa. Based on the evidence that his father's name was also L. Varius Ambibulus, his sister's name is Varia, and his freedmen were Varii, Olli Salomies argues his original name was Lucius Varius Ambibulus, and the terms of a testamentary adoption one Quintus Planius Sardus directed Ambibulus to add his name to Ambibulus' in return for a share of the latter's estate. However, Werner Eck and Margaret Roxan present another possibility, based on a military diploma owned by Martin Schøyen, that mentions an equestrian "Q. Planius Sardus", the commander of ala I Ulpia contrariorum milliaria. Noting the nomen gentile "is otherwise rare in the senatorial and equestrian classes", they argue that Ambibulus is related to this equestrian, adding the "Quintus Planius Sardus" element in his name from his mother's side.

Career
The career of Ambibulus up to his consulate can be reconstructed from a damaged inscription erected in Cuicul in Numidia; it was erected by order of the civic government to honor him as their patron. In this inscription, all of his posts are listed in chronological order, except oddly for the first in the list, a hitch as military tribune in a legion whose name is mostly missing. In the order Ambibulus held these offices, he began his career in his teenage years as one of the decemviri stlitibus iudicandis, which was one of the four boards comprising the vigintiviri. The traditional Republican magistracies followed: quaestor, plebeian tribune, and praetor.

After stepping down as praetor, Ambibulus served as praefectus frumentus dandi ex senatus, then was selected by the sortition to be proconsular governor of Macedonia in 124/125. This was followed by two commissions as legatus legionis or commander of legions: Legio I Italica in Moesia, and Legio III Augusta in Numidia; we know from other sources he commanded a Legio III in 132. Subsequently, Ambibulus was suffect consul; his career after his consulship is unknown.

References

2nd-century Romans
Roman governors of Macedonia
Suffect consuls of Imperial Rome
Ambibulus, Lucius
Ancient Roman adoptees

redpajama_set_name: RedPajamaWikipedia


We sell 2nd hand vinyl, 45s, 12 inch singles and LPs. We also have a limited selection of 2nd hand books about music and occasionally have a record player or two to sell.
All LPs are $4 each or 3 for $10.
We are upstairs in Crown Chambers. Take the steel stairway next to Hideaway Cafe on Church Street to the first floor. Near where the old guys play giant chess in the mall.


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S. Aureus was identified by Sir Alexander Ogston in 1880. Since then it is carried by approximately 30% of the population, and can be found as a normal inhabitant of the skin flora viz. in the nostrils and reproductive tract of women. S. Aureus is non-motile and anaerobic, while being viewed as a "grape-cluster berry" under the microscope. Reproducing asexually by means of binary fission. Its non motility characteristic, causes it to be spread through human to human contact, or by contact of contaminated surfaces and foodsii. Similarly, MRSA is spread mostly by human to human contact through the hands and infrequently through the cough of patient infected with MRSA pneumonia iii.
S. Aureus is the foremost cause of infective endocarditis, bacteremia, skin infections, and device related infections.
In developed nations, the S. Aureus incidence ranges between 10 to 30 per 100 000 population, with hospital acquired infections being the key contributor. It was suggested that the bacteria is carried via healthcare workers from pets, to working environments. Due to S. Aureus being found as inhabitants of domestic pets. Additionally, it can be transferred from infected patients to non infected patients, through healthcare workers. Studies show that S. Aureus can survive for up to three months on polyester fabric, i.e. hospital privacy curtains. Simarlarly, MRSA can survive on surfaces and fabrics.
MRSA infection incidence rate has fluctuated, increasing from 0 to 7.4 per 100 000 population in Quebec, Canada. Since 2005, there has been reduced incidence of MRSA, possibly due to improved infection control procedures. Incidence of S. Aureus is highest in infants and rising with advancing age (above 70 years of age). Those individuals with HIV/AIDS have a significantly higher incident rate viz. 494 per 100 000 population and 1960 per 100 000 population according to two separate studies.
S. Aureus is diagnosed through laboratory testing of appropriate specimen samples. The bacteria is identified by utilising a biochemical or an enzyme based test. Whereas, MRSA is diagnosed through quantitative PCR procedures, broth microdultion tests, cefoxitin disk screen test, and the latex agglutination test in order to promptly identify strains.
MRSA can be reduced / prevented by using ethanol as a surface sanitising agent, as well as quaternary ammonium. Other measures are screening patients for MRSA (using nasal cultures) prior to hospital admissions, in order to prevent cohabitation of MRSA. Those infected with MRSA, should be decolonized and / or isolated from non infected patients. These clinical areas need to be subjected to terminal cleaning methods.
S. Aureus clinical infections are likely to persist, due to its increasing antimicrobial resistance and evolution. In the last 20 years there has been an increase in nosocomial infections, especially prosthetic device infections and infective endocarditis, not to mention the epidemic of community associated skin and soft tissue infections. At this stage the old adage prevails i.e. prevention is better than cure.
Prishani Reddy. "Difference Between Methicillin-Resistant Staphylococcus Aureus (MRSA) and Staphylococcus Aureus." DifferenceBetween.net. August 1, 2017 < http://www.differencebetween.net/science/health/difference-between-methicillin-resistant-staphylococcus-aureus-and-staphylococcus-aureus/ >.
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Impact of Symbolic Gesturing on Early Language Development, Journal of Nonverbal Behavior, 24, 81-103 (2000). Link to paper 2. Linda P. Acredolo, and Susan W. Goodwyn, The Longterm Impact of Symbolic Gesturing During Infancy on IQ at Age 8, International Conference on Infant Studies (July 18, 2000: Brighton, UK).
Baby Sign Language: Hindering or Enhancing Communication in Infants and Toddlers? by. Mellisa J. Cesafsky. A Research Paper. Submitted in Partial Fulfillment of the. Requirements for the. Master of Science Degree. In. Education. Approved: 2 Semester Credits bt. The Graduate School. University of Wisconsin-Stout.


text:
Nick Nolte Joins Fox Event Series 'Gracepoint' as Series Regular
The Academy Award nominee joins previously announced cast members Anna Gunn, Jacki Weaver and Michael Pena
Tony Maglio | December 23, 2013 @ 8:32 AM	Last Updated: July 10, 2014 @ 7:38 PM
Nick Nolte is joining Fox's event series, "Gracepoint," in the series regular role of Jack Reinhold.
Reinhold is described as a stubborn, unmarried, willful man, who has lived in titular town Gracepoint for 20 years. He runs the kayak rental on the beach as well as the local wildlife observation program, where the murdered boy at the center of the plot was one of his volunteers.
Nolte is a three-time Academy Award nominee, most recently for Best Supporting Actor for his role in "Warrior", and a Golden Globe winner. He joins previously announced cast members David Tennant ("Det. Emmett Carver"), Anna Gunn ("Ellie Miller"), Jacki Weaver ("Susan Wright"), Michael Peña ("Gangster Squad"), Kevin Rankin ("Paul Coates"), Virginia Kull ("Beth Lasseter") and Kevin Zegers ("Transamerica").
See video: Adam Levine Thanks America, Ryan Gosling – and Nick Nolte – For Sexiest Man Alive Honor
Nolte most recently starred in "Gangster Squad," "Parker," and "The Company You Keep." His upcoming feature film projects include "Return to Sender," directed by Fouad Mikati, and the film adaptation of bestselling novel, "A Walk in the Woods," in which he will be co-starring with Robert Redford. Nolte is represented by CAA.
Also read: 'Breaking Bad's' Anna Gunn, 'Silver Linings Playbook's' Jacki Weaver Cast in Fox Crime Series 'Gracepoint'
Produced by Shine America in association with Kudos and Imaginary Friends, "Gracepoint" is scheduled to begin filming in January, for broadcast during the 2014-2015 season. The crime series will be executive-produced by the original series' creator, Chris Chibnall ("Dr. Who," "Camelot"), with Shine America's Carolyn Bernstein ("The Bridge"), Kudos' Jane Featherstone ("The Hour," "Utopia"), Dan Futterman ("Capote," "In Treatment") and Anya Epstein ("In Treatment," "Homicide"). Futterman and Epstein will serve as showrunners. Chibnall will write the premiere episode and James Strong ("Broadchurch," "Downton Abbey") is signed on to direct. The series will be distributed by Shine International.
"Gracepoint" is a 13-episode adaptation of British hit "Broadchurch."
Hollywood's Best & Worst Casting News of 2013 – From 'Batman vs. Superman' to 'Fifty Shades'
By Jeff Sneider | December 20, 2013 @ 11:41 AM
Adam Sandler to Guest as Himself in Post-Super Bowl 'Brooklyn Nine-Nine'
By Tony Maglio | December 12, 2013 @ 5:32 PM
'Breaking Bad's' Anna Gunn, 'Silver Linings Playbook's' Jacki Weaver Cast in Fox Crime Series 'Gracepoint'
By Tony Maglio | November 18, 2013 @ 10:00 AM


text:
Divoký anděl (ve španělském originále Muñeca brava) je argentinský televizní seriál, romantická telenovela s komediálními prvky. Premiérově byl vysílán v letech 1998–1999 na stanici Telefe, v původní podobě čítal 285 dílů, mezinárodní verze obsahuje 270 epizod. Ústřední dvojici ztvárnili Natalia Oreiro a Facundo Arana, pro něž to byl díky celosvětovému úspěchu této telenovely počátek mezinárodní kariéry. Většina seriálu byla natočena v Buenos Aires a okolí, některé díly ale byly filmovány také v Itálii a ve Španělsku.

Příběh
Milagros vyrůstala v Buenos Aires od svého narození s dalšími dětmi v klášteře, jehož sestry se starají o sirotky. Její matka totiž zemřela při porodu a otce nikdy nepoznala. Velkým koníčkem dívky je fotbal, který hraje s dalšími dětmi z ulice. Díky tomu má přezdívku Cholito, podle argentinského fotbalisty Diega Simeoneho, zvaného Cholo. Po dovršení 18 let se Milagros dostane jako služka do zámožné rodiny Di Carlových. Ve vile La Soledad, kde žijí, pozná nové přátele, ale i zákeřné a intrikářské osoby, a to jak mezi ostatním personálem, tak mezi členy rodiny. Její hlavou je otec Federico, který sice vede rodinnou stavební firmu, ale zároveň většinou svého příbuzenstva pohrdá. Jeho syn, sukničkářský playboy Ivo, má vztah s otcovou ambiciózní a všehoschopnou sekretářkou Andreou, ale zároveň si užívá i s dalšími děvčaty. Dobrosrdečná a upřímná Milagros, kterou do problémů mnohdy přivede její prořízlá pusa, se stane služebnou Federicovy matky Angéliky, která téměř nevychází z domu a truchlí pro své ztracené vnouče. Dívka se navíc zamiluje do pánova syna Iva, který její city opětuje, jenže jejich případnému vztahu není ze strany rodiny přáno.

Obsazení

Ústřední dvojice
 Natalia Oreiro (český dabing: Ivana Andrlová) jako Milagros "Mili" Esposito, zvaná Cholito
 Facundo Arana (český dabing: Ivan Jiřík) jako Ivo Di Carlo

Hlavní role
 Fernanda Mistral (český dabing: Hana Maciuchová) jako Luisa Di Carlo, Ivova matka
 Verónica Vieyra (český dabing: Olga Želenská) jako Victoria "Vicky" Di Carlo, Ivova sestra
 Lydia Lamaison (český dabing: Růžena Merunková) jako Angélica Di Carlo, zvaná Madam (v originále Doña), Federicova matka
 Victoria Onetto (český dabing: Eva Spoustová) jako Adelina "Lina", zvaná Motýlek (v originále Mariposa), služebná u Di Carlových
 Norberto Díaz (český dabing: Oldřich Vlach) jako Damián Rapallo, Luisin bratr
 Mariana Arias (český dabing: Mahulena Bočanová [do 119. dílu, vyjma 14.–17. dílu], Zuzana Skalická [14.–17. díl, od 120. dílu]) jako Andrea Ramosová, sekretářka v podniku
 Silvia Baylé (český dabing: Jana Drbohlavová) jako Amparo Rodríguezová / Socorro Rodríguezová, kuchařka u Di Carlových
 Segundo Cernadas (český dabing: Vladislav Beneš) jako Pablo Rapallo, Damiánův syn
 Osvaldo Guidi (český dabing: Libor Terš) jako Bernardo Avelleyra, majordomus u Di Carlových
 Valeria Lorca (český dabing: Veronika Jeníková) jako Martha Rodriguezová, zvaná Martička (v originále Martita), dcera Socorro, služebná u Di Carlových
 Gabriela Sari (český dabing: Kateřina Lojdová) jako Gloria Esposito, kamarádka Milagros z kláštera, služebná u Di Carlových
 Pablo Novak (český dabing: Michal Michálek) jako Alfredo "Bobby" de Solo, Ivův kamarád
 Gino Renni (český dabing: Radovan Vaculík) jako Ramón García Parapuchino, zahradník u Di Carlových
 Marcelo Mazzarello (český dabing: Tomáš Juřička) jako Morgan "Rocky", řidič u Di Carlových
 Arturo Maly (český dabing: Vladimír Brabec [do 233. dílu], Jiří Prager [od 234. dílu]) jako Federico Di Carlo, Luisin manžel

Produkce
Přímým předchůdcem Divokého anděla byla komediální telenovela Casablanca, v níž měli ústřední dvojici ztvárnit Natalia Oreiro a Leonardo Sbaraglia. Seriál měl pojednávat o mladé chudé dívce z venkova jménem Rosa (Oreiro), která přijde do Buenos Aires, kde začne pracovat v restauraci, kde se zamiluje do intelektuálního kuchaře Diega (Sbaraglia). Režisérem byl Rodolfo Ledo, jenž psal i scénář. Natáčení bylo zahájeno počátkem května 1998, produkce byla ovšem v červenci zastavena. Hlavním problémem byl Ledo, který doslova ze dne na den ze studia zmizel a v dopise oznámil, že měl tvůrčí spory s vedením televizní společnosti Telefe a že se kvůli zdravotním problémům odjel léčit na jih Argentiny. V té době bylo zfilmováno 22 dílů, tedy asi třetina z konečného počtu epizod objednaných Telefe, kterých mělo být 60. V důsledku odchodu Leda opustil pořad i představitel hlavní role Sbaraglia. Producent Raúl Lecouna najal dalšího režiséra a scenáristy, aby seriál dokončili. Použitelných (po úpravě a střihu) však bylo pouze prvních deset dílů, zbytek by musel být s jiným hercem natočen znovu. Vynechány by taky byly různé scény a zápletky, které obsahovaly velmi specifický Ledův humor. Společnost Telefe nakonec počátkem srpna 1998 projekt zrušila, i když do něj investovala asi 2 miliony dolarů.

Úspěšný telenovelový tvůrce Enrique Torres následně začal pro Telefe rychle pracovat scénáři k novému seriálu, který měl Casablancu nahradit, a který z ní přejal některé prvky. Do připravovaného projektu přešla řada herců, kteří často získali obdobné role, jako měli ztvárnit ve zrušené telenovele, včetně hlavní představitelky Natalie Oreiro, jež nově měla být chudým sirotkem a služkou v zámožné rodině. Do páru byl k ní nakonec vybrán Facundo Arana, který v té době působil v dětské muzikálové telenovele Chiquititas. Produkce Divokého anděla byla zahájena počátkem října 1998, natáčelo se ve studiích Sonotex v Martínezu, kde původně vznikala i Casablanca. Pro exteriéry byla použita především vila v San Isidru, která představovala vilu La Soledad, a areál Instituto Carlos Pellegrini v Pilaru, jenž byl zobrazen jako klášter. Štáb však pro jednotlivé díly využil i vzdálenější lokace: Luján, Zelayu, vodopády Iguazú, lyžařské středisko Bariloche v Andách či město Carmelo v Uruguayi. Natáčelo se ale i v Evropě, ve Florencii, v Římě a na Ibize.

V seriálu byla využita hudba z debutového eponymního alba Natalie Oreiro, které bylo natočeno v první polovině roku 1998 a které vyšlo v létě 1998. Pro znělku posloužila píseň "Cambio dolor", k níž byl nově natočen videoklip, rovněž použitý ve znělce. Balada "Me muero de amor" byla využita jako milostný hudební motiv hlavních představitelů, jako podkres při establishing shotech zní úryvky z dalších písní této desky. Jako jednorázoví hosté se v Divokém andělovi objevili Claudia Maradonová, manželka Diega Maradony, či fotbalista Gabriel Batistuta (oba ztvárnil sami sebe). Závěrečný díl byl natočen koncem listopadu 1999, poslední svatební scéna byla filmována v areálu Instituto Carlos Pellegrini.

České znění
České znění vyrobila v letech 1999 a 2000 společnost CET 21 ve společnosti Produkce pod režijním vedením Jany Michajlové a v překladu Nikoly Brudera, Petra Klímy, Aleny Křížkové a Jindřišky Mendozové. Natalii Oreiro poprvé nadabovala Ivana Andrlová.

Vysílání
Seriál byl vysílán ve všední dny po 13. hodině. Úvodní díl byl na obrazovkách uveden 16. listopadu 1998, poslední epizodu diváci zhlédli 17. prosince 1999. Celkem vzniklo 285 dílů, přičemž mezinárodní verze Divokého anděla obsahuje 270 epizod, které jsou částečně odlišně sestříhány.

V Česku byl seriál premiérově vysílán na TV Nova od 22. května 1999 do 10. října 2000. Uváděn byl zprvu o víkendu, nejprve v podvečer před 18. hodinou, posléze dopoledne kolem 11. hodiny. Od září 1999 se na obrazovkách objevoval po celý týden v podvečerním čase (kolem 18. nebo 19. hodiny), což bylo na konci roku 1999 zredukováno pouze na pracovní dny.

Přijetí
V Argentině se Divoký anděl dočkal diváckého úspěchu, pravidelně dosahoval prvních příček v žebříčcích sledovanosti. V letech 1998 a 1999 získal cenu Martína Fierra v kategorii telenovel, na dalších sedm byl v jiných kategoriích nominován. Seriál byl úspěšně prodán i do zahraničí, populární se stal například v Izraeli, kde v roce 2000 získal čtyři ceny Viva, nebo v Rusku.

I v Česku byl seriál z diváckého hlediska úspěšný. Průměrně jej (ve skupině 15–54 let) sledovalo 623 tisíc diváků, Rating dosáhl hodnoty 10,3 % a share 58,9 %, takže se po Esmeraldě jednalo o druhou nejsledovanější telenovelu.

Díky úspěchu seriálu začaly být, jak je v žánru telenovel zvykem, natáčeny remaky Divokého anděla. Jako první to byl portugalský seriál Anjo Selvagem (2001–2003), v latinskoamerickém prostoru se pak jednalo o mexickou telenovelu Al diablo con los guapos (2007–2008) a o peruánskou La Tayson, corazón rebelde (2012). Adaptace se však objevily i v Indii v podobě seriálu Miilee (2005–2006) a v Indonésii jako seriál Hafizah (2009–2010).

Odkazy

Reference

Externí odkazy

  Muñeca brava na oficiálním YouTube kanálu televize Telefe

Argentinské telenovely
Argentinské dramatické televizní seriály
Argentinské komediální televizní seriály
Argentinské romantické televizní seriály
Televizní seriály vysílané od roku 1998
Televizní seriály vysílané do roku 1999


The only error I have a slight hint on why it's not working is the "No such file or directory" because I don't have the file '.unicorn.sh' in my rails app for some reason. I would greatly appreciate help!
I just tried to use it and spent several hours already to make it deployable via Capistrano. Encoutered several problems already. Did you managed to set it up properly?
When will the Ruby on Rails one-click App be updated?


Free Version of the Marketplace was Launched!
Our promising journey started on 08 February 2013 by Kawshar Ahmed, the CEO and Founder of the marketplace. At that time, the marketplace was branded as ShapeBootstrap.
It was so inspiring! In August 2014, the marketplace received the 200th free theme. We always prioritize quality over quantity.
In February 2015, the marketplace crossed the 2 million download mark. The sellers and the community members are awesome!
We promised to offer a fantastic experience to both the theme developers and users. The users asked more quality products and developers wanted to help them. That's why we started to accepting premium themes.
The community is our life. Thanks to all for being with us! And It was February 2016 when we crossed 150,000 member registrations.
We always work to improve the visitors' experience with the marketplace. In May 2016, we launched our brand new site design.
The Marketplace Gets a Fresh New Look!
We added Payoneer as a payment withdrawal method to the marketplace. Anyone with an account on our site can add Payoneer to their profile on this marketplace.
In September 2017, our journey to the next big thing started with ThemeHunt. The marketplace gets a new look, new branding and an overhauled UX. The future is here!
Journey to the Future Begins with ThemeHunt!


text:
"Intezar" by Mustafii will give you strength to fight when the whole world is against you and you need patience.
The track "Intezaar" defines as "Patience" and "Hustle" of an Artist to accomplish his/her dreams in life. The rapper speaks about his hustle when he started this artistry (Music) as a hobby and how it made him go all serious into this tantrum acts of the society and people in his daily life. He questions the god on "why we humans were created in such a way that any of the relations we make with others get broken up and we carry the pain on our hearts".
First of all, the track "Intezaar" defines as "Patience" and "Hustle" of an Artist to accomplish his/her dreams in life. The rapper speaks about his hustle when he started this artistry (Music) as a hobby and how it made him go all serious into this tantrum acts of the society and people in his daily life. The rapper tells to his listeners on how he never used to give up on his Dreams and how the world now has become an "emo" and thinks only about "sensualising their partner" at times of doing something productive and how he used to do the same in his initial times as a teenager. He questions the god on "why we humans were created in such a way that any of the relations we make with others get broken up and we carry the pain on our hearts and vice versa – Do the same with others…". The track was been made in a mood where the artist was going through his mental illness and was reminding himself that how he got stronger with every step he took in his past life to get in a place where he feels capable of doing almost everything in such a age and feels one of the rare ones right now. In the end the rapper makes people to believe in themselves and learn on the mistakes they make through in life. After all you just need to keep "Patience".
The inspiration behind this track came from my own hustle.
It took 3 Perfect days to compose,record, mix and master the track.
The meaning of the lyrics of the track is to keep Patience and have Faith on yourself.
Another next banger.
Previous: "Kahan Mai Hoon" by Revoic is a song about the seeking of the inner world and wanting to know the source of all the possibilities of the mind.
Next: Panvi Podder's single "Story to tell" breaks the myth of marriages ending in "Happily ever after".


text:
Bat Facts
Bats Are Mammals: Like humans, bats are mammals. They have hair and give birth to living young, feeding them on milk from mammary glands.
Bats Live a Long Time: Bats can live as long as 30 years in group colonies, but can't live without them.
Bat Babies: Bats typically only have one baby (called a pup) each year.
Bat Swarm: is nocturnal, and is never found aboveground in daylight. Their built-in sonar allows bats to accurately fly with great speed through total darkness, avoiding objects larger than themselves, including humans.
Bats Are Bug Catchers: Most bats feed on insect pests such as mosquitoes, moths and beetles. One bat can eat as many as 1,000 insects in just one hour.
Bats Are Night Owls: They are nocturnal, flying and foraging for their food at night.
Bats Are Helpful: Bats found in tropical areas feed on fruit and nectar. These bats serve an important ecological role as seed dispersers and pollinators and many plant species depend almost entirely on bats for pollination.
Dwarf Epauletted Fruit Bat (Micropteropus pusillus): This type of bat is native to countries in the central and southern parts of Africa. It feeds mostly on juice it extracts from small fruits, drinking 2.5 times its body weight in a single night. Bats are transporters of many viruses that do not affect them due to their unusually high immune system efficiency. Micropteropus pusillus bats have been known to carry antibodies specific to Ebola.
Bats Are Diverse: There are more than 900 bat species worldwide.
Bats Are Precise: Each bat has its own, individual "voice" with which it can judge the size and distance of an object as fine as a human hair.
Where to Find Bats: Bats can be found living in trees, on cliff faces or in rock crevices; but, the vast majority of bats live in caves.
Fruit Bat (suborder Megachiroptera, family Pteropodidae): The fruit bat's diet consists of fruit, as its name suggests. It is a relatively large bat, known as a Megabat, and does not navigate by echolocation. It relies on its keen senses of sight and smell to locate food. Fruit bats can be found in tropical locations throughout the world.
Bats Are One of a Kind: They are the only mammals that can fly.
Bats Have Hands: The bones in a bat's wing are the same as the bones of the human arm and hand. The bat's fingers are elongated and connected by a double membrane of skin, which forms the wings.
Indiana Bat: Live in our very own Squire Boone Caverns. The ideal shelter for bats is caves, caves provide comfortable safety from predators. Some of the most successful species of bats live in large cave colonies that number in the millions!
Bats Have Great Hearing: A bat's sense of hearing is so sensitive it can hear the footsteps of a walking insect.
Bats Have Sonar: Echolocation is the mechanism bats used to find food and avoid flying into obstacles. They are able to emit and hear noises too high for the human ear to distinguish. The sound waves bounce off objects and back to the bat's keen ears, enabling it to locate, identify and capture moving prey in the dark.
Lyle's Flying Fox (Pteropus lylei): A type of fruit bat, these flying foxes are found in Cambodia, Thailand, and Vietnam. They are a very social species and form large colonies high up in trees.
Bat Myths
Bats Are Blind: Most bats can see as well as humans. Many bats have eyesight that is adapted to low-light conditions, much like cats.
Bats Get Tangled In People's Hair: Their built-in sonar allows bats to accurately fly with great speed through total darkness, avoiding objects larger than themselves, including humans. If a bat swoops toward you, it's probably after a mosquito hovering just above you.
Bats are Just Flying Mice: Bats are not flying mice; they are not even remotely related to rodents. Bats are such unique animals that scientists have placed them in a group all their own, called Chiroptera, which means "hand-wing." Bats are grouped with primates and lemurs in a grand order called Archonta.
Lesser False Vampire Bat (Megaderma spasma): Found in South Asia and Southeast Asia from India in the west to the Philippines in the east. They live in caves and tree hollows, and eat only insects
Bats Suck Your Blood: Undoubtedly, the most famous bats are vampire bats, which are found in Latin American countries. These small bats feed on the blood of warm-blooded animals such as birds, horses and cattle, but they do not attack humans and they do not suck blood.
They obtain their meal by making a small incision in the skin of an animal with their razor-sharp teeth, then lapping up the blood that flows from the wound. The bat's saliva contains a substance that actually helps numb the animal's skin, so it's likely the cut is hardly felt at all. Because vampire bats need only about two tablespoons of blood per day, the loss of blood to a prey animal is minimal.
Lesser Horseshoe Bat (Rhinolophus hipposideros): A type of European bat that gets its name from its distinctive horseshoe-shaped nose. It is one of the world's smallest bats, weighing less than an ounce, with a body length of about 1.5 inches. It is quick and agile, flies very close to the ground when hunting for food, and can see well in spite of its small eyes.
Bats Carry Rabies: Bats do not "carry" the rabies virus, though they can contract the disease just like any other mammal. Less than one-half of one percent of all bats are infected with rabies, however, and rabid bats are seldom aggressive.
Death as a result of contact with a bat is extremely rare. That doesn't mean it's safe to touch or try to hold bats, as they might become frightened and bite in self-defense. Grounded bats are more likely to be sick, and should be approached only by professionals trained to handle them.
Bats Are Ugly and Dirty: Most bats have very cute faces, and some even resemble deer, rabbits, and little Chihuahuas. Like cats, bats spend an enormous amount of time grooming their fur, keeping it soft and silky.
Common Vampire Bat (Desmodus rotundus): Found in the tropics of Mexico, Central America, and South America, this is the only mammal that feeds entirely on blood, mostly from cattle and horses.
Click here to learn more about bats!


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text:
J Tru Soldier4Christ Releases Epic new album titled One 29 Twelve, which is the date his life was radically transformed. Listen to the hope from the perspective of a individual living a hopeless life
J Tru Soldier4Christ August 23, 2019
Denver, Colorado — Friday, August 23rd, 2019 — One 29 Twelve is not only an Album but a testimony of a young man living a life of hopelessness, with the intent to inquire street credibility as a way of survival. To become a young man of faith, and now living a life for others to follow.
Jose Trujillo artist name J Tru Soldier4Christ has worked closely with another artist on this album of mutual purpose, such names as R Swift, Bryann Trejo, Sean Be, and many others. In an attempt to reach a wider range of listeners that may have once walked in the very footsteps he walked. His full intention for the album isn't to reach a position of stardom, but more in the intent of bringing the very ministry that was brought to him. To the ears of many others who may not be able to hear it physically but yet the opportunity to hear it digitally, with hopes to make a change and decision that could affect there lives in a positive way forever. Sometimes in a world that's dying one song can bring life.
J Tru Soldier4Christ isn't asking for much but mainly support to help get the album into the right hands so not only himself but many others can be benefited through it.
With the correct backing, production and skill level that J Tru Soldier4Christ has it's almost a guarantee that the world can be impacted in the right way.
Quote: "If you can't reach them on the street, reach them on a beat" J Tru Soldier4Christ
One 29 Twelve is not just an album for the listener to listen to but more of the approach to change someone's life through the lyrics that are presented from it.
If you don't believe me take a listen for yourself.
https://distrokid.com/hyperfollow/jtrusoldier4christ/one-29-twelve-3
https://www.youtube.com/channel/UCfllOAYvhTBXKtGHgvbVU4A/playlists
J Tru Soldier4Christ real name is Jose Trujillo was born in Albuquerque NM where he got himself involved with the wrong crowd from the beginning and from then on continued to live his life based on gang violence, drugs, alcohol, Etc. At the age of 26 years, old Jose found himself at the lost point of his life and, had to make a change for the better. Therefore Jose moved out to Denver Colorado attended the ministry of Victory Outreach and surrendered his life to Christ. Since then Jose has been making music that glorifies Jesus in any way possible in an attempt to reach the world with the message of hope.
Throughout the course of his musical career, J Tru Soldier4Christ has won over the hearts of music lovers from all walks of life. Performing at a variety of venues, making dozens of appearances, all the while recording new singles, J Tru Soldier4Christ has earned the admiration and affection of countless fans, serving as both inspiration and role model due to his faith in Jesus Christ.
J Tru Soldier4Christ
« Army Veteran Motor Mouth Takes Things To The 'Next Level' With New LP » Dell Feddi Presents His 2019 Release 'Game On Wax'


text:
Q: Не работает добавление текста из Input при нажатии на кнопку "add item" Переношу логику и данные из компонента во VUEX. При вводе текста в input в консоле пишет ошибку ** this.saveCats is not a function**. Так же текст из input не добавляется и кнопка удаления не работает. Как должно работать: при нажатии на кнопку ADDD SOME ITEM идёт проверка введено ли что-то в поле input и если да ,то после этого на страницу добавляется введённый в input текст и кнопка для его удаления DELET CAT, так же он сохраняется в localstorage и оттуда возвращается при новом открытии страницы.
Помогите пожалуйста поправить код, что бы все нормально заработало во VUEX.
Как это работает сейчас

Вот наглядно как должно работать

Код в компоненте
 <f7-block strong>
    <f7-block-title>Some items</f7-block-title>
      <f7-block v-for="(cat, n) in compCats">
          <span>{{ cat }}</span>
          <f7-button fill color="red" @click="removeCat(n)">Delete Cat</f7-button>
      </f7-block>

        <f7-list form>
            <f7-list-input
              :value="compNewCats"
              @input="newCatOnInput"
              type="text"
              placeholder="Заметка"
            ></f7-list-input>
            <f7-button fill color="blue" @click="addCat">Add some item</f7-button>
        </f7-list>
  </f7-block>

<script>
export default {
computed:{
    compCats() {
        return this.$store.getters.cats;
    },
    compNewCats(){
        return this.$store.getters.newCat;
    }
},

mounted() {
  if (localStorage.getItem('cats')) {
    try {
      this.cats = JSON.parse(localStorage.getItem('cats'));
    } catch(e) {
      localStorage.removeItem('cats');
    }
  }
},
methods: {
    addCat(e) {
    this.$store.commit('addNewCat');
    },
  newCatOnInput(e){
      this.$store.commit('newCatInput',  e.target.value);
  },
  removeCat(n){
      this.$store.comit('removeSomeCat');
  }

}
}
</script>

Код во VUEX
export default new Vuex.Store({
    state: {
      cats:[],
      newCat: null
    },
    getters:{
        cats(state){
            return state.cats;
        },
        newCat(state){
            return state.newCat;
        }
    },
    mutations: {
     addNewCat(state) {
       // убедиться, что было что-либо введено
       if (!this.newCat) {
         return;
       }
       this.state.cats.push(this.state.newCat);
       this.state.newCat = '';
       localStorage.setItem('cats', JSON.stringify(this.state.cats));
     },
      removeSomeCat(x) {
          this.state.cats.splice(x, 1);
          const parsed = JSON.stringify(this.state.cats);
          localStorage.setItem('cats', parsed);
      },
      saveCats(state) {
        const parsed = JSON.stringify(this.state.cats);
        localStorage.setItem('cats', parsed);
        },
      newCatInput(payload) {  //передаём событие из input и записываем в новую переменную
          this.newCat = payload;
        },
    }
});

A: Ты не можешь вызывать одну мутацию внутри другой. Да и непонятно зачем это делать. Я вижу такой вариант:
addNewCat(state) {
  // убедиться, что было что-либо введено
  if (!this.newCat) {
    return;
  }
  this.state.cats.push(this.state.newCat);
  this.state.newCat = '';
  localStorage.setItem('cats', JSON.stringify(this.state.cats));
}

То есть не нужно в сторе вот этим заниматься. Мутация принимает 2 значения, одно из которых обязательно state. А другое - нагрузка, т.е. та инфа, которую передать надо. В твоём варианте ты вызываешь saveCats() без аргументов, хотя функция предполагает наличие как минимум одного - state. Если есть большое желание, то вынеси функцию saveCats() за пределы export default, и вызывай просто как функцию, а не как метод вьюекса.

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