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Insulin receptor signaling in the development of neuronal structure
Category: Cholecystokinin2 Receptors
Data Availability StatementThe data used to support the findings of the study can be found in the corresponding writer upon demand
Cholecystokinin2 Receptors	by	insulinreceptor
Data Availability StatementThe data used to support the findings of the study can be found in the corresponding writer upon demand. group and sham-operated group, ST portion in the model group elevated in II considerably, III and aVF. 3.2. XBTYF Inhibited Morphological Adjustments in Cardiomyocyte From Amount 2, we noticed which the myocardial cells in the control and sham-operated rats had been neatly organized and even, without crimson ischemic adjustments. Myocardial cells in the model rats had been organized with ambiguous disorder, followed by inflammatory cell infiltration, huge fiber deposition region, and vascular fibrocyte proliferation. When XBTYF was implemented on the high dosages (3.2?g/kg), just a small amount of Cefodizime sodium inflammatory cells were infiltrated and arteries proliferated slightly. The result of low-dose XBTYF (0.8?g/kg) was the poorest due to the current presence of inflammatory cell infiltration, huge fiber deposition region, and vascular fibrocyte hyperplasia. Open up in another window Amount 2 Myocardial morphology was observed by HE staining (level pub?=?50?> 0.05), and results showed that it was significantly downregulated by XBTYF whatsoever doses (3.2, 1.6, and 0.8?g/kg) (< 0.05), with high dose showing the greatest effect. Open in a separate window Number 3 Characterization of mitochondria in cardiomyocytes. (a) Mitochondrial morphology was observed by TEM (level pub?=?5?< 0.05 vs. model. 3.4. XBTYF Reduced Cardiomyocyte Apoptosis To examine whether XBTYF exerts an effect on cell apoptosis, we performed TUNEL staining to MSN measure cell apoptosis and western blot to detect the manifestation of Bax, Bcl2, caspase 3, and caspase 9. All data are normally distributed (> 0.05), and we perform statistical analysis using one-way ANOVA. The results in Figure 4(a) exposed that degree of cell apoptosis in the model rats was higher than that in XBTYF-treated rats (< 0.05). With the increase in XBTYF concentration, cell apoptosis decreased gradually. The levels of Bax, caspase 3, and caspase 9 in the model group were much higher compared to those in the control, sham-operated, high-, medium-, and low-dose XBTYF organizations, whereas Bcl2 manifestation was decreased (Number 4(b)). Open in a separate window Number 4 Evaluation of cardiomyocyte apoptosis after XBTYF treatment. (a) Cardiomyocyte apoptosis was recognized by TUNEL assay (level pub?=?50?< 0.05 vs. model. (b) Manifestation of apoptosis-related proteins Bax, Bcl2, caspase 3, and caspase 9 was assessed by western blot, and the manifestation of Bax, caspase 3, and caspase 9 was significantly decreased, while Bcl2 manifestation was increased compared to the model. Ideals represent the average of three replicates, < 0.05 vs. model. 3.5. XBTYF Promoted Angiogenesis via VEGF-Notch1/Dll4 Pathway We measured the manifestation of VEGF-A, Notch1, and Dll4 to evaluate whether XBTYF promotes angiogenesis through the VEGF-Notch1/Dll4 pathway. The manifestation data of VEGF-A, Notch1, and Dll4 were normally distributed (> 0.05). From Number 5, we observed that compared with the model group, the manifestation of Notch1 and Dll4 was significantly decreased by XBTYF whatsoever doses, whereas that of VEGF was improved. High-dose XBTYF (3.2?g/kg) had the greatest effect among all XBTYF organizations. Open in a separate window Number 5 Protein manifestation of VEGF, Notch1, and Dll4 was measured by western blot. Compared with the model group, the manifestation of Notch1 and Dll4 was significantly decreased by XBTYF whatsoever doses (3.2, 1.6, and 0.8?g/kg), whereas that of VEGF was increased. Ideals represent the average of three replicates, < 0.05 vs. model. 4. Conversation Myocardial ischemia refers to a decrease in blood perfusion in the heart, resulting in conditions Cefodizime sodium such as hypoxia and irregular energy rate of metabolism [15, 16]. CHD is the main cause of myocardial ischemia. With the improvement of living requirements, the prevalence of myocardial ischemia in China is definitely increasing yearly and it has become a frequently happening disease in elderly people. In recent years, studies on the pathological mechanisms of myocardial ischemic injury have been highlighted in myocardial ischemia research [17C20]. Treatments based on traditional Chinese medicine have Cefodizime sodium shown potential applications in myocardial ischemia treatment, and this has been reported in Cefodizime sodium many studies. Ji [21] found that supplementing qi and activating blood circulation clearly improved the clinical symptoms of myocardial ischemia. Wu and Liu [22] observed that Danggui Buxue Tang protected rats against myocardial ischemia by reducing the expression of inflammatory factors. Chen et al. [23] indicated that Shuangshen Tongmai Granules reduced the expression of oxidative stress-related factors and the apoptotic rate of cardiomyocyte. XBTFY is a well-known traditional Chinese medical formulation that has been widely used in clinical settings [24]. Our previous experiments revealed that XBTYF protected the heart of rats with myocardial ischemia by promoting angiogenesis [12, 13], but the underlying mechanism of action involved therein remains unclear. Wang et al. [25] found that crocetin.
Background/Aims It really is now recognised that gastric dysrhythmias are best characterised by their spatial propagation pattern
Background/Aims It really is now recognised that gastric dysrhythmias are best characterised by their spatial propagation pattern. waves propagated symmetrically and antegrade. The blood glucose levels were improved by an average of 112% compared to the baseline by the end of the recordings. All subjects demonstrated elevated incidence of sluggish wave dysrhythmias following injection compared to the baseline (48 23% vs 6 4%, 0.05). Dysrhythmias arose simultaneously or individually on anterior and posterior serosa. Spatial dysrhythmias occurred before and persisted after the onset and disappearance of temporal dysrhythmias. Conclusions Infusion of glucagon induced gastric sluggish wave dysrhythmias, which occurred across a heterogeneous range of patterns and frequencies. The spatial dysrhythmias of gastric slow waves were shown to be more prevalent and persisted over a longer period of time compared to the temporal dysrhythmias. test was used to test statistical differences occurring during baseline and infusion of glucagon (significance threshold 0.05). Mean values with standard deviation are reported as appropriate. Results Slow wave recordings with adequate coverage for mapping propagation were obtained from all subjects prior and following injection of glucagon. Direct HR mapping exhibited regular slow waves from both anterior and posterior surfaces of the stomach, the normal propagation pattern was comparable to previous HR mapping studies in canine subjects.8,19 The baseline recording was on average 21 8 minutes. Gastric slow waves were recorded over an average duration of 59 15 minutes following the induction of hyperglycemia. A total of 512 cycles of slow waves, on average 128 62 cycles per subject, were analyzed following infusion of glucagon. Sophocarpine Overall, the effects of hyperglycemia were significantly different compared to the baseline activity (Table). Over all analyzed cycles, on average, 48 23% of cycles showed dysrhythmias on spatiotemporal analysis, which was elevated compared to the baseline (6 4% with abnormal propagation characteristics; 0.05). Table Definitions of Spatial Gastric Slow Wave Dysrhythmias 0.0001). Glucagon also increased the velocity between 0.1C0.8 mm/sec compared to baseline ( 0.09). However, periods of both tachygastria and bradygastria were observed in all subjects (Fig. 2). A notable feature was that dysrhythmia was evident as spatial propagation abnormalities as early as 7 minutes following injection of glucagon, and remained active until the end of the recording period (Fig. 2B), despite the amplitude, velocity, and frequency all returning to baseline. Frequencies in the tachygastria range were especially evident during a period of fluctuation from a slight depression at a rate of -42 mg/dL/5 min Sophocarpine to recovery at a rate of 32 mg/dL/5 min of the BL measures between 15 to 30 minutes (Fig. 2A). The frequency of slow waves was elevated and exhibited larger fluctuations during this period compared to the slow waves outside this period (CI [3.9, 4.5] vs CI [2.5, 2.8] cpm; 0.001). In general, the dysrhythmias were highly dynamic, often transitioning from one type into another within a short interval. For example, a sustained re-entry accompanied with tachygastria of up to 30 seconds could be determined before regressing back to regular propagation carrying out a amount of quiescence (Fig. 3), which occurred in two-fourths topics. Furthermore, the sluggish waves in the posterior surface area were also discovered to propagate in the retrograde path through the re-entry period in the anterior surface area. The antegrade propagation that happened following a amount of quiescence was similar towards the baseline data in Shape 1, although frequency was decreased towards the bradygastria array significantly. Open in another window Shape 3 A dysrhythmic and tachygastria bout of gastric sluggish waves during hyperglycemia. (A) Activation maps of the beginning, post and mid dysrhythmia are shown. The 1st and third (waves 1 and 3) cycles both demonstrate the standard path of propagation (Fig. Rabbit polyclonal to PPP1R10 1A), whereas the next wave (influx 2) illustrates an bout of figure-of-8 re-entry. (B) The chosen electrograms proven that tachygastria (up to 12 cpm) was from the amount of re-entry (up to 30 mere seconds), accompanied by a 63 mere seconds of quiescence, before recovery back again to the normal path of propagation, apart from the dual potentials in a few Sophocarpine from the posterior stations (p4Cp7). Sophocarpine Dysrhythmias caused by ectopic distal pacemaker happened in three-fourths topics. Occasionally (Fig. 4), repeated distal ectopic pacemaker had not been in a position to invoke retrograde propagation atlanta divorce attorneys cycle, because of conduction blocks. With this example, the common interval of.
Lower respiratory an infection caused by human being pathogens such as influenza and respiratory syncytial disease (RSV) is a significant healthcare burden that must be addressed
Lower respiratory an infection caused by human being pathogens such as influenza and respiratory syncytial disease (RSV) is a significant healthcare burden that must be addressed. address these difficulties. Lu AF21934 The finding of influenza and RSV peptidic fusion inhibitors will become discussed and compared to small molecules in view of escape mutations. The importance of constraining peptides into macrocycles to improve both their inhibitory activity and pharmacological properties will become highlighted. study to engineer and display for the best preF antigens in animals, prior to their software to human being (14). Currently, 18 RSV vaccine tests and 21 preclinical development programs are under development (16). Probably the most encouraging candidate is an RSV F nanoparticle-based vaccine of Novavax. This vaccine is definitely under development against young infants, pregnant women, and the elderly. The maternal immunization phase 3 medical trial is the most advanced (17, 18). The vaccine is definitely a prefusogenic F protein encapsidated into a nanoparticle Lu AF21934 and complemented with an aluminium adjuvant to boost immunization. The primary endpoints of the phase 3 clinical trial have been met and the scholarly study will be unblinded shortly; the info are promising and claim that the first RSV vaccine could be approved by the U.S. Medication and Meals Administration shortly. It will be precious to find out, in case there is achievement, if the adjuvant is normally well tolerated with the fetus (and, by expansion, by the youthful newborns), and if the immunization of the vaccine can prolong beyond 1C2 a few months. Persistence of maternal antibodies in the neonate Lu AF21934 could be as well short to attain reliable security unless an extremely high titer of neutralizing antibodies is normally reached. Additionally, the timing of immunization can impact on degree of transplacental antibody transfer in the mother towards the fetus. Since no vaccines can be found to eliminate the seasonal flu currently, antiviral substances are had a need to deal with the infected sufferers. The current regular of treatment against flu goals two proteins, the matrix-2 (M2), a proton-selective ion route proteins, or the neuraminidase (NA) proteins. M2 allows the migration of H+ ions in to the interior of trojan particles, an activity that occurs upon endosome acidification and is necessary for trojan uncoating that occurs. NA cleaves the sialic acidity that is utilized by the trojan to bind towards the web host receptor, thereby enabling the release from the trojan from the contaminated Lu AF21934 cell and further distributing in the sponsor (19). The licensed drugs focusing on M2 are amantadine (Symmetrel) and rimantadine (Flumadine), belonging to the class of adamantane derivatives, and the ones focusing on NA are oseltamivir (Tamiflu), zanamivir (Relenza), and peramivir (Rapivab). In basic principle, these antivirals are common and can be used against all strains of influenza disease. However, resistance strains have emerged in the last two decades and have become a severe issue. The use of the adamantane derivatives resulted in the appearance of several escape mutants in viruses isolated from man and avian in the transmembrane region of the M2 protein (20, 21). In particular, the S31N was shown to be present in all H3N2 and 15.5% of the H1N1 influenza A viruses worldwide by 2006 (22, 23). Resistance improved dramatically in the United States in a period of 10 years, starting from only 2% prevalence in 1999, to 15% in 2005, and finally 96.4% in 2006. In some Asian countries such as China, adamantane resistance was already recognized in 70% of all disease isolates in 2004. On the other hand, the H274Y NA mutant resistant to oseltamivir and peramivir offers naturally appeared in 2007 and is now present in virtually all H1N1 Rabbit Polyclonal to RFWD2 disease isolates (24). This still leaves the option of using the adamantanes to treat the infections due to H1N1 and oseltamivir to treat the infections due to H3N2. Even in the case that a disease resistant to both adamantanes and oseltamivir would appear to become predominant (25), zanamivir could still be used. However, because zanamivir is an inhalable drug, Lu AF21934 which requires the use of an unfriendly device to administer the compound, this option cannot be used to treat the pediatric human population, the elderly, and individuals with chronic airway disease such as asthma or chronic obstructive pulmonary disease (COPD) (26). In addition to this, a diagnostic tool must be available to determine quickly the subtype of the influenza disease for a quick clinical decision. Recently, a peptide-based.
Dental care implant diseases, peri-implantitis (PI) and peri-implant mucositis (PIM), have shown wide prevalence in recent studies
Dental care implant diseases, peri-implantitis (PI) and peri-implant mucositis (PIM), have shown wide prevalence in recent studies. validity (level of sensitivity and specificity). A number of encouraging diagnostic techniques were recognized. Commercially available chair-side checks for MMP-8 to diagnose periodontal disease and PID activity are now available. Long term directions include proteomics and metabolomics for accurate, site-specific diagnosis and prediction of Clorprenaline HCl PID progression. Although more research is needed, this review concludes that the assessment of proinflammatory cytokines (IL-1, TNF, MMP-8) in the PICF may Clorprenaline HCl be of value to diagnose PI and PIM but current research remains insufficient to indicate whether biomarkers predict peri-implant disease progression. and [4]. When compared to periodontitis in natural teeth, PI was more frequently linked with opportunistic pathogens of bacterial, fungal and viral origins which points to a heterogenous infection [4]. Some individuals are believed to be more susceptible to peri-implantitis. Current evidence indicates a potential influence of various gene polymorphisms in the pathogenesis of peri-implantitis; however, prospective clinical studies Clorprenaline HCl with sufficient sample size are currently lacking [4]. Gram-negative bacterias will be the most significant bacterias isolated through the periodontal wallets of organic tooth regularly, such as for example: [12]. Nevertheless, a recent organized review described the need for new pathogens, such as for example Desulfobulbus spp., Filifactor alocis and TM7 spp., in periodontal disease [12]. Though Notably, periodontal disease around organic tooth isn't triggered by the current presence of particular bacterias most likely, but by adjustments in the known degrees of the human population from the species in the oral microbiome. The traditional medical solution to assess implant wellness carries a periodontal probe to gauge the pocket depths also to notice blood loss upon probing. Sadly, this simple device has restrictions. The lack of a periodontal ligament around implants as well as the prosthetic style may make evaluation of pocket probing depth measurements challenging to execute and interpret. Additionally, the implant mucosal seal may have much less resistance to probing in comparison to natural teeth. This may result in induced bleeding when probing around healthy implants mechanically. However, the curing from the epithelial connection appears to be full five days after clinical probing, hence, does not seem to jeopardize the longevity of implants according to an animal study [13]. Radiographs should be standardized and compared to reference radiographs taken at the time the implant was placed in function. Furthermore, there is no practical model to predict the progression of PI [1]. Predicting disease progression is an essential component to form a prognosis. Treatment protocols cannot be easily compared without a valid prognosis. Non-surgical therapy of PI is often ineffective, and the treatment of choice is a surgical approach [11]. Surgical techniques may include open flap debridement with removal of the inflammatory tissue and mechanical and chemical decontamination of the exposed implant surface. Recontouring of the bony smoothing and architecture of the implant surface may improve disease control. Regenerative procedures utilizing a membrane and bone tissue graft substitutes wanting to partly fill up the bony problems due to peri-implantitis could be effective [14]. Therapy of peri-implantitis accompanied by regular supportive treatment resulted in beneficial medical improvements and steady peri-implant bone tissue levels in nearly all patients relating to a organized review [15]. Early analysis of PID and its own rate of development certainly are a great concern. Evaluation of biomarkers may assist in early recognition of PI. Biomarkers might help both in staging and grading of periodontitis in the entire case description program of periodontitis [16]. Peri-implant crevicular liquid (PICF), also referred to as peri-implant sulcular liquid (PISF), may consist of biomarkers to diagnose and forecast potential disease which supports choosing a particular treatment protocol. A biomarker can be a parameter that's assessed and examined as an sign of regular natural objectively, pathogenic procedures, or Clorprenaline HCl reactions to a restorative intervention [17]. Substances in the gingival crevicular liquid (GCF) gathered from organic teeth have already been thoroughly studied. Substances such as for example lactate dehydrogenase and myeloperoxidase have already been looked into to determine Nefl if indeed they could be utilized as markers for periodontal pathology and in the achievement of treatment modalities [18]. Another strategy was referred to in a recently available report which discovered that calculating glycosylated hemoglobin in gingival crevicular was effectively used to display for diabetes control inside a dental office placing [19]. The.
Supplementary MaterialsSupplementary Desk?1 mmc1
Toll-like receptors (TLRs) play an important role in immune system reactions to pathogens by transducing indicators in innate immune system cells in response to microbial items
Supplementary Components1
nonviral vectors, such as for example lipid-based nanoparticles (liposome-protamine-DNA complex [LPD]), could be used to deliver a functional gene to the retina to correct visual function and treat blindness
5- Receptors
Annexin
ATPase
AXOR12 Receptor
Ca2+ Ionophore
Cannabinoid (GPR55) Receptors
CCK Receptors
Corticotropin-Releasing Factor1 Receptors
DHCR
DMTases
DNA Methyltransferases
Endothelin Receptors
EP1-4 Receptors
Exocytosis & Endocytosis
Glutamate (Kainate) Receptors
Glutamate (Metabotropic) Group III Receptors
Glutamate (NMDA) Receptors
Glutamate Carboxypeptidase II
Glycogen Phosphorylase
Glycosyltransferase
GnRH Receptors
Imidazoline Receptors
IMPase
Inositol Phosphatases
Kisspeptin Receptor
LTA4 Hydrolase
M1 Receptors
Matrixins
Melastatin Receptors
mGlu Group III Receptors
Motilin Receptor
Neutrophil Elastase
Nicotinic (??4??2) Receptors
NKCC Cotransporter
NMU Receptors
Nociceptin Receptors
Non-selective 5-HT
Opioid, ??-
Orexin2 Receptors
Other Transcription Factors
PPAR
PPAR??
Proteasome
PTH Receptors
Serotonin (5-HT2B) Receptors
Serotonin Transporters


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Home › Commands & Colors Tricorne: The American Revolution
Commands & Colors Tricorne: The American Revolution
For 2 players, playing time around 60-90 minutes.
Commands & Colors Tricorne - The American Revolution is not overly complex. The game is based on the highly successful Commands & Colors game system, where the Command cards drive movement while creating a "fog of war" and the battle dice resolve combat quickly and efficiently. Commands & Colors Tricorne - The American Revolution, however, introduces many new game concepts, which will add historical depth and provide even the most veteran Commands & Colors player many new play experiences and challenges.

redpajama_set_name: RedPajamaCommonCrawl


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THE ORDINARYS "I Wanna Be An Ordinary"
The Ordinarys should have been massive - an appearance on hit TV show "New Faces" and a fan in the legend that is Mickie Most should have got the band the recognition their talent deserved. But some reasons unknown they never released anything.... until now!
Love Child Records are more than happy to put out this long-lost piece of '78 New Wave / early Mod Revival lushness.


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San Diego Resident Sponsors First-Generation College Students
By Sam Guin | October 20, 2018 | 0
Abhishek Sharma teamed-up with Education First to sponsor the organization's annual scholarships given to local low-income students who want a college degree. Awards are given to high school seniors who are often the first in their families to attend college.
Abhishek immigrated to the US when he was 15 and remembers his parents taking factory and retail jobs to make ends meet. Their first accommodations were in a basement with no hot water.
For Abhishek, he remembers the countess scholarships and mentors who helped him throughout his education. He graduated from Bowdoin College and recently earned his MBA at the Haas School of Business at UC Berkeley. He now works as a Senior Product Manager at Dexcom, a manufacturer of continuous glucose monitoring devices which help patients and healthcare professionals better manage diabetes.
Abhishek is committed to "paying it forward" to students who aspire to go to college in order to fulfill their career goals. Here he is seen with winners Marco Tamez and Islam Ahmed from Crawford High School.
Marco is headed to San Diego State University to study business while Islam plans to earn a degree in aviation from Harris-Stowe State University.
In addition to their respective scholarships to assist with tuition, access to a professional college coach is also provided by Education First though a strategic partnership with College Forward.
Abhishek says, "College can be full of unpredictable obstacles – this way they have more than just a paper check, but the needed support to be successful in school."
Join Abhishek and donate to Education First
Education First Awards Multiple Scholars From One Family
Denver Students' College Dreams Realized
Windermere Does it Again in Seattle!
Former Scholar Joins Education First as Volunteer While Pursuing her Master's Degree
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Prior to the Bahrain Grand Prix world champion and Sebastian Vettel were being written off by m simply were not the dominant force of a year ea appeared that the Adrian Newey penned RB8 w successor to the very handy RB7 of last year. Well all the downfall theories went to shred bounced back to secure a hard fought for, but t deserved victory in the Sakhir desert. With th took command of the points standings, while rivals at McLaren, Ferrari and Mercedes faltered Thus the F1 circus heads to Europe with fou winners out of four races, and the closest cont to enthrall fans. It was also great to see Kimi Raikkonen an Grosjeanon on the podium for Lotus - we now teams (if you count Ferrari and their F2012) lin the grid as potential winners on any given Sun In this issue we take a look back on an intri controversial Bahrain weekend. Enjoy!


There's something percolating in Seattle besides coffee. It's a robust, piquant, blend of jazz that's as characteristic of the region as its scenery. Harder-edged than the laid back California brew south of it, but not as off the wall as some of the new music coming out of Vancouver, B.C. to the north, UNDULATIONS is a perfect definition of what you can expect there.
Spearheaded by bassist Michael Bisio, this CD shows off the talents of accomplished musicians able to go their own way outside the usual jazz media spotlight. We shouldn't make too much of the Northwest singularity, through. Bisio is actually a native of Troy, N.Y., who in Seattle, has worked with such present and past East Coasters as saxophonists Joe McPhee and Charles Gayle and trumpeter Barbara Donald.
A fine composer, who wrote four of the seven tunes here, the bassist is an amiable sort, who is just as happy to "walk" as solo. No showoff, he cultivates a deep, woody tone that makes it quite clear he's playing a doublebass, as he demonstrates at the beginning of Blakeslee's "Give Up the Chair". That Portland, Ore.-based brassman has also been associated with another West Coast iconoclast Vinny Golia. Veteran Nell specializes in half florid/half modal solos — think of McCoy Tyner meeting Sergey Rachmaninoff —, while Pias prefers offbeat patterns to a steady pulse ignoring cymbal hisses and snare hits. Finally Nolet, a frequent Bisio duo partner, plays as if combos featured a viola are an everyday occurrence, letting the fiddle serve the unison frontline function a saxophone would have in a hard bop quintet.
Ear training could be facilitated with this CD. So much is going on at one time that when you start concentrating on any soloist — say Blakeslee's variations in the middle of "Grimes, Henry Grimes", you often get aurally seduced by, for example, the non-standards inventions Pias is coaxing from his hands and feet. And wait, isn't that Randy Weston's "Hi Fly" sneaking on the bass and horns?
No foot tapper, instead the first track, as the title says, undulates. Alive as it is with hearty bass plucks, curving piano explorations, airy flugelhorn lifts, violin scratches and considered drum rolls, the tune manages to be non-standard without falling into the trap of self-conscious experimentation.
A fresh breath of air from the Northwest, this CD shows how musicians outside major jazz centres are subtly extending the tradition, no matter how static certain generational spokesmen want it to remain.


The Social Confidence 6 Set CD Kit – Guide To Social Confidence is backed with a 60 Day No Questions Asked Money Back Guarantee. If within the first 60 days of receipt you are not satisfied with Wake Up Lean™, you can request a refund by sending an email to the address given inside the product and we will immediately refund your entire purchase price, with no questions asked.
The People's Coach Guide to Social Confidence is a 6 part audio programme and a 50 page accompanying manual. The audio programme is downloaded on MP3 file to your computer for your convenience and the manual is received on pdf. The audio programme is professionally recorded and contains both exercises and powerful eyes closed processes that will help you make the changes rapidly from the inside out.
CD2: Let Go of Social FearsLearn how to take control of your own brain and use it to re-program and let go of unnecessary Social Fears.
CD3: Supreme Social ConfidenceInfluence the feelings and physical sensations in your body and develop states of confidence and certainty.
CD4: Achieving Deep Natural ConnectionConnect deeply with people conversationally, behaviourally and from the inside out in a way that is natural, honest and authentic.
CD5: The Power of SexualityManage your sexual energy to become more attractive to people in general and effortlessly move a relationship to a more sexual level.
CD6: The Social skills AcceleratorRapidly improve your level of social skills and the way you interact with people.
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Each Audio recording contains information, techniques and a powerful eyes closed process at the end. The eyes closed processes make use of the latest psychological change tools, NLP (Neuro linguistic Programming) and some hypnosis. When you listen and actively imagine, participate and experience the things you are asked to, during these processes, you will find yourself making rapid, positive changes for the long term in your levels of confidence, social skill and general attractiveness.
You sure do! When you purchase your People's Coach Guide to Social Confidence… you will receive two high quality bonuses specifically designed to help you become more confident, socially skilled and attractive.
If you are either looking for a partner or just looking to exponentially raise your levels of attractiveness in general and be blissfully happy with just being yourself, then this report will help you do that.
Peta (known as the original 'flirt coach') has trained with some of the world's top personal development mentors including Richard Bandler, Joseph Riggio, John LaValle and Tony Robbins. She is a licensed trainer of Neuro Linguistic Programming [NLP] and one of only a few licensed Mythoself-tm facilitators in the world. She will show you how to attract the right person for you and she does this in a way that you will find easy, fun and enjoyable.
Described as the "Wild Woman of NLP" by John la Valle (Richard Bandlers co-trainer) Peta runs weekend courses in Europe and the USA helping both sexes access their very best and learn how to flirt your way to success. She has appeared on numerous television and radio programmes including GMTV, Richard and Judy, Big Brother, Pop Stars the Rivals, This Morning, Open House, Kilroy, Trisha, and over 40 other shows in the last five years. Channel 4 also made a documentary about the Flirting Academy in 1999. Over the last 10 years. She is the author of 4 bestselling books and has personally helped thousands of people in her workshops and individual consultations to find the life they want.
Owen Fitzpatrick is co-author of "Conversations" with Dr Richard Bandler. He is one of Europe's top Motivational Speakers, Personal Development Trainers and the youngest ever Licensed NLP Master Trainer in the world (of which there are only a handful).
Owen is a qualified Psychologist, Hypnotherapist and Psychotherapist. He has a Masters in Psychology, he has trained people in Ireland, Britain, Europe, Mexico, India and the United States of America and has his own T.V programme in Ireland called 'Not enough hours'.
Since becoming the youngest ever qualified Hypnotherapist at 17, Owen has worked continuously with those suffering from depression, fears, phobias, panic attacks, shyness and relationship problems helping them to own their brains and change their lives. He's now worked individually with thousands of people in these areas and countless more in his trainings. He is recommended by and has co-trained with Dr Richard Bandler (co-founder of NLP and best selling author).
Owen has also trained extensively with some of the best NLP trainers in the world such as John Le Valle, Tony Robbins, Judith Delozier, Eric Robbie, Michael Breen and Paul McKenna. Owens sharp sense of humour, his amazing ability to teach complex subjects in simple ways and his powerful inspirational energy in teaching and training are some of the reasons why he is regarded, by many in the field, as one of the best NLP trainers in the World.
We know you'll be happy with the Guide to Social Confidence. So much so that we offer an unconditional 60 day money back guarantee. If, for any reason, you feel that the programme has not met your expectations then get in touch by email at info@thepeoplescoach.co.uk and we will process your refund, no questions asked.
Purchasing your People's Coach Guide to Social Confidence couldn't be easier. Simply click on the box below and it will take you through the payment procedure. Once your payment has been successful you will be directed straight to the download page. If you have any additonals questions about the guide please feel free to get in touch by email at info@thepeoplescoach.co.uk and we'll be happy to answer any questions you have.


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Entrepreneurs seize pandemic opportunities to start or grow businesses
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LAURIE WELCH, and COLIN TIERNAN
Employee Rosa Gutierrez cuts meats while co-owner Jennifer Anderson is reflected in the window helping a customer Wednesday at Burly Meats in Burley.
DREW NASH, TIMES-NEWS
Stocking filled with goodies hang on the mantle Thursday, Dec. 10, 2020, at Perrine Man Press in downtown Twin Falls.
Cory Paulson, owner, rings up items Thursday, Dec. 10, 2020, at Perrine Man Press in downtown Twin Falls.
BURLEY — When the COVID-19 pandemic cleared meat from the store shelves in April and May, the owners of Burly Meats found their small butcher shop, opened in 2019 — flooded with orders, prompting an expansion to a much larger store.
Owners Jennifer and Jeremy Anderson and their partner Cameron Smith, doubled the employees at the shop to 10 and recently expanded from a 250-square-foot shop on Railroad Avenue in Burley to a 3,300-square-foot location, 655 N. Overland Ave., near Interstate 84 exit 208. They also own a feed yard north of Paul, where they raise cattle and a processing plant on U.S. Highway 30, west of Burley.
"We opened the butcher shop because we had people who kept coming into the processing plant asking for meat," Jennifer Anderson said.
Many Magic Valley business owners who are not afraid to take risks and make changes to meet their customers' needs are opening new businesses — or expanding during the pandemic.
Co-owner Jennifer Anderson chats with a customer Wednesday, Dec. 9, 2020, at Burly Meats in Burley.
Some of the factors that make it a good time to open a business include low-cost loans and grants, a displaced workforce and affordable rental space.
"All of those things kind of come together in a recession," Twin Falls Economic Development Director Nathan Murray said.
There is also an emotional component.
"Sometimes people are just at their wits' end," Murray said.
They feel like things can't get any worse, so they think they might as well take the leap and start a business.
There are many examples of people starting businesses in recessions — Uber in 2009 for instance. There are many major companies that were born out of recessions — for good reason.
"There's a good history of companies that are kind of forged in fire, took risks when a lot of negative things were going on around them," Murray said.
For Jennifer Anderson, her husband, and their partner, expanding right now just made sense.
The larger shop allows them to sell grills, along with aprons and other cooking accessories, and they are working on a deal to provide grass-fed and finished beef to their customers. They also have fresh tortillas.
"A lot of bigger businesses like the national chains went out of business but a lot of us pulled up our bootstraps and went to work," Anderson said.
Burley Economic Development Director Doug Manning said construction permit values in the city were down a bit in 2019 but they came back strong in 2020.
In Burley, the valuation of building permits in 2020 through November totaled $33.32 million compared to the same period in 2019 of $9.16 million, according to city reports.
"What we're seeing is business expansion and new businesses taking advantage of opportunities," Manning said. "The pandemic hasn't affected what we're doing here. We're as busy as we've ever been."
Manning said available housing is still lagging behind, which can hamper growth slightly.
"If we had another 100 new houses on the market they'd be sold within 30 days," he said.
"From my perspective, we're thriving and I don't see it slowing down," Manning said.
The year 2021 promises to be "pretty exciting," he said.
"We will have to have something more chaotic than what we've seen with the pandemic to slow it down," Manning said.
National brands fold, making way for the new
For some larger chains and national brands that were struggling pre-pandemic, the pandemic brought insurmountable financial challenges and they went under.
New businesses might not be as financially extended as major corporations and they can be more flexible, Murray said.
"We are definitely in a unique time with COVID-19," Region IV Development Association President and CEO Jeff McCurdy said.
Employee Emma Rogers presses fresh hoodies Thursday at Perrine Man Press in downtown Twin Falls.
McCurdy said the Magic Valley's economic climate has done better than some areas of the country partly because it was in a strong growth phase prior to the virus outbreak.
"It's certainly slowed some businesses down, but others have seized the opportunities," he said.
Region IV helps companies with small business development, lending and servicing business loans, municipal project development and grant writing.
"I think the Magic Valley is doing so well because Idaho is still open for business, while other states are shutting down," College of Southern Idaho Professor of Economics Mike Pohanka said.
Homes are being built and all sizes of businesses are opening or expanding, he said.
"They feed off of each other," he said.
Lower tax rates and a "substantially less cost of living," he said, certainly play a role in enticing new business to the area, along with the available workforce.
While the region's unemployment rates have not completely bounced back to pre-coronavirus rates, they have recovered somewhat from a peak of nearly 12% in April, McCurdy said.
That shows there are still workers out there waiting to be hired.
According to the Idaho Department of Labor, the state's unemployment rate at the end of October was 5.5 % compared to a rate in October 2019 of 2.9%. Twin Falls' October rate was 5.3% compared to 2.7% in 2019, Cassia County was 4.0 % compared to 2.4 in 2019 and Jerome County was 4.4% compared to 2.4% in 2019.
Housing interest rates also remain low and that industry is exploding across the Magic Valley, he said.
One challenge that remains for residential or commercial construction is shortages of building materials, McCurdy said.
"Construction costs have gone up and if someone started building during this they've seen costs increase," McCurdy said.
But the business opportunities are plentiful for those willing to take a bit of a risk, said McCurdy.
"Probably all businesses have been affected to some degree," he said. "But there are a lot of programs helping business owners."
Many companies have been able to make adjustments, like restaurants that before April did not have carryout service, and have now put in drive-thru windows or are offering Door Dash or curbside service, he said.
Many businesses were able to make modifications because of increased funding options provided by the Cares Act and other sources, he said.
Previously, grants for mom and pop businesses were unheard of, he said, now there are some available.
Businesses willing to adapt and modify their traditional business processes, he said, can not only survive during this time, but flourish.
McCurdy said the Magic Valley may have lost some business opportunities during the last nine months, but it has remained in better shape than other parts of the country.
In some places, he said, development organizations are struggling to find businesses willing to take the risks to build or expand right now, and they can't get the relief funding available out to them.
How the economic climate changes over the long haul will be interesting, he said.
More people now work remotely for companies, and they may decide to relocate to more rural areas like the Magic Valley.
Murray said it appears that Californians and people from other states are migrating to Idaho because they don't like the lockdowns in their states.
"People vote with their feet," he said.
Other reasons they are migrating to Idaho include fewer regulations and a good sense of place, he said.
"I would rather live in the area that has higher population growth than higher job growth even, because I think that it's a signal that you have a good quality of life," Murray said.
Optimism spurring growth
All business in the Magic Valley remains somewhat "buffered by the ag industry," Pohanka said, although the Southern Idaho economy is "somewhat diversifying."
That buffering may also have played a role in how well businesses have weathered the pandemic.
The stock markets have also continued to perform well, he said, which inspires confidence in business owners.
Twin Falls Area Chamber of Commerce CEO Shawn Barigar said optimism plays a major role in business and good business people don't let a good crisis pass them by.
During challenges like a recession or a pandemic, intuitive business people figure out a way to take advantage of that as opposed to being beaten down from it. It brings out an entrepreneurial spirit in people.
"It's an opportunity as opposed to an impediment," Barigar said, who is not surprised by the numbers of new businesses springing up in Twin Falls.
The growth has occurred throughout the city and new businesses have outweighed the closures.
Optimism, he said, plays a huge role in business.
Burly Meats grows
Employee Rosa Gutierrez prices meat while Jennifer Anderson helps customers in the background Wednesday, Dec. 9, 2020, at Burly Meats in Burley.
Perrine Man Press(es) on amid pandemic
Employee Emma Rogers works Thursday, Dec. 10, 2020, at Perrine Man Press in downtown Twin Falls.
Customers shop for meat Wednesday, Dec. 9, 2020, at Burly Meats in Burley.
Cory Paulson, owner, helps customers Thursday, Dec. 10, 2020, at Perrine Man Press in downtown Twin Falls.
A screen used to stamp clothes is seen Thursday, Dec. 10, 2020, at Perrine Man Press in downtown Twin Falls.
Red meat seen in the freezer Wednesday, Dec. 9, 2020, at Burly Meats in Burley.
A variety of hats are for sale Thursday, Dec. 10, 2020, at Perrine Man Press in downtown Twin Falls.
Employee Rosa Gutierrez cuts carne asada on Wednesday, Dec. 9, 2020, at Burly Meats in Burley.
WATCH NOW: Christmas tree cutting adventure
Burly Meats
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Idaho health leaders OK crisis health care rationing rule
Idaho's top public health leaders on Friday cleared the way for state officials to impose crisis standards of care if the number of COVID-19 patients increases so much that the state's already strained hospitals wind up completely overwhelmed.
Twin Falls schools opting for additional in-person days following winter break
Under this new schedule, which begins on Jan. 4, students in every grade will attend class in person on Tuesday through Friday, leaving Monday as a distance learning day.
Mini-cassia
Police: Burley man accidentally shoots himself in the leg
A Burley man accidentally shot himself in the leg Sunday while showing his new gun to people.
COVID-19 infections way down in Magic Valley, but not in Idaho
Magic Valley COVID-19 cases are down significantly, unlike the statewide numbers.
No room at the shelter: Valley House homeless housing full, nonprofit looks for help
The housing is completely full, but it expects to break ground on a new 15 unit complex at the end of February or early March.
County fairs across the Magic Valley saw losses during COVID-19 pandemic
Preliminary reports show the Cassia County Fair & Rodeo will have a $10,000 net loss after it receives an $18,000 CARES ACT reimbursement for the fair and rodeo held in August.
Minidoka County Fair & Rodeo also saw a loss this year of $7,745 and Twin Falls County Fair reported a 40% drop.
Watch Now: MC veterans group delivers gifts, salute to fellow veterans at nursing homes
A handful of veterans gathered at Highland Estates' front lobby to receive a salute from their fellow brothers in arms along with a box of gifts and a Christmas stocking teeming with goodies.
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Business is good despite the pandemic at a locally-owned restaurant in Hollister.
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I have finally got this into the site after finishing the Summer edition of Photoworld - up till 3 in the morning for several days on that! Now I can finally pay the bills which have been buried for three weeks, the red reminders always come before I have even had time to look at the originals - that's what magazine deadlines are like.
Re: Which Sony Alpha kit lens?
This has been a very helpful article, but it is ultimately very Sony-centric. Could we ever expect a review/comparison including third party offerings? For instance, "Fast" standard zooms for APS-C, Sony 16-80 vs Sigma 17-70 vs Tamron 17-50. Of course, "super-zooms" becomes a much smaller party.
I only included those lenses you can buy as a kit. The Tamron and Sigma are not as far as I know being bundled with Sony cameras as kits, even by independent dealers. But I may have time to do that - or maybe someone else has got all three lenses that you mention.
The third-party kit lens business is a strange one. I know a company which is desperate to get rid of hundreds of 18-50mms because a camera maker just updated their own 18-55mm to be IS, and now no-one wants third party, non-stabilised kit lenses! You can probably guess who.
I wasn't aware that the 16-80 and 18-250 were packaged in kits...must be a Europe or UK only thing. The kits we were offered on these shores were 18-70, 16-105, and 18-200.
I managed to find a retailer offering the 18-70 as a no-cost upgrade over the a700 body only, and nobody around had the 16-105 kit.
The difficult one to get here has been the 16-105mm in a kit. All of the lenses have been packaged in kits one way or another, but not with every body. The least common is the 18-250mm as they had lots of 18-200mms to get rid of.


Ski Racing includes several different types of Downhill Skiing. Popular types of Ski Racing are Alpine Skiing and Speed Skiing, which is one of the fastest land based, non motorised sports. Ski Racing often involves speeding down a snowy slope while slaloming through flagged poles. This is arguably the most well-known type of Ski Racing, it is an Olympic sport and is included in many ski events and competitions around the world.
Please select Ski Racing (Other Than Ski School).
The policies with our Adventure policy only covers Single Trip for anyone aged 18 years or younger. If you require a quote for an Annual policy, you will need to call us and we can provide you with a quote through a different provider.
Here are some example quotes based on a 25 year old travelling to Europe for 5 days for Ski Racing.
With the introduction of greater safety measures and precautions, including crash pads, safety nets and more clearly marked courses, Ski Racing is safer now then it once was.
However, as an extreme Winter Sport, the precedent for sustaining an injury whilst partaking in Ski Racing is still high.


if you have enjoyed the above story and would like to start from the beginning please check out the archives.
Welcome to the Adventures of Gar.
Created from the insane mind of Jason F. Talbert, using LEGO to tell the tales of Gar and his crazy life in Bricksville, USA.
This is the next generation of Gar's Space on the web. We will be using LEGO as the medium for our stories and explorations into the realm of silliness.
Because we here at The Adventures of Gar believe in 99% silly and 1% seriousness in the stories we tell.
authorize or endorse this web site.


text:
Diphtheria is a serious bacterial disease that causes severe inflammation of the nose, throat and windpipe (trachea).
Diphtheria is extremely rare in developed nations including Australia because of the widespread use of the diphtheria vaccine.
Symptoms of diphtheria
Diphtheria and skin infection
Complications of diphtheria
How diphtheria is spread
Diphtheria – high-risk groups
Diagnosis of diphtheria
Treatment for diphtheria
Prevention of diphtheria
Immunisation against diphtheria
Diphtheria is a serious communicable bacterial disease that causes severe inflammation of the nose, throat and windpipe (trachea). It is caused by the bacterium Corynebacterium diphtheriae. The bacteria produce toxins that cause an abnormal membrane to grow in the throat, which can lead to suffocation.
Other dangerous complications include paralysis and heart failure if the toxins spread throughout the body. Around 10 per cent of people exposed to diphtheria die from the disease.
Diphtheria is extremely rare in most developed countries, including Australia, because of the widespread use of the diphtheria vaccine. However, it is important to continue vaccinating children against diphtheria because there is a risk that the infection can be brought in by people who have travelled to or come from developing nations.
Symptoms of diphtheria may include:
severe sore throat
generally feeling unwell (malaise)
swollen lymph nodes in the throat
a furry grey or black coating on the throat membranes, which is made up of bacteria and dead cells
swallowing problems.
Sometimes, diphtheria causes a skin infection. The wound is sore, inflamed and full of pus and may be surrounded by greyish skin patches. This condition is known as cutaneous diphtheria. It is quite rare in developed countries.
Without treatment, the extremely serious and potentially lethal complications of diphtheria can include:
suffocation, as the abnormal throat membrane obstructs breathing
heart damage, including inflammation (myocarditis) or congestive heart failure
kidney damage
nerve damage, with health problems depending on which nerves are affected.
Diphtheria is most commonly spread when someone ingests (swallows) or inhales the cough or sneeze droplets from an infected person. Symptoms occur between two and 10 days following infection.
Sometimes, a person has such a mild case of diphtheria that they don't realise they are sick. However, they are still contagious for about six weeks and may infect a lot of other people. An apparently healthy person who spreads an infectious disease is called a 'carrier'.
Diphtheria is very rare in Australia. People at increased risk of diphtheria include:
unimmunised or incompletely immunised people exposed to a person infected with diphtheria
people who have immune system problems
people living in unhygienic and crowded conditions
travellers to particular areas known to harbour diphtheria such as South-East Asia, Russia and surrounding countries, Baltic countries and Eastern European countries.
Tests used to diagnose diphtheria may include:
medical history including immunisation status
travel history
swabs of the throat (or wound) for laboratory testing.
If diphtheria is suspected, treatment begins before the test results are back from the laboratory. Treatment may include:
isolation to prevent the spread of infection
antibiotics, such as penicillin, to destroy the bacteria
diphtheria antitoxin given
other medicines to reduce the risk of adverse reactions to the vaccine, for example corticosteroids, adrenaline or antihistamines
surgery to remove the grey membrane in the throat, if necessary
treatment of complications, for example medications to treat myocarditis
bed rest for about six weeks or longer, depending on the severity of the illness.
The best prevention against diphtheria is immunisation.
People who are caring for someone with diphtheria should practise strict hygiene – for example, wash hands frequently, particularly before handling, preparing or eating food – and get a booster vaccination. All contacts should also receive a course of antibiotics.
In Victoria, the diphtheria vaccine is available in a combined vaccine that also contains protection against other serious and potentially fatal diseases.
The diphtheria vaccine contains a weakened form of the bacterial toxin, called a toxoid. It works by prompting the body to produce an 'antitoxin' – a specific antibody that neutralises diphtheria toxin. A number of doses are needed to offer good protection against diphtheria.
Different vaccines are available depending on the person's age group. A free combined vaccine that offers protection against diphtheria is available for all Victorian children when they are:
two, four and six months of age – in the form of a diphtheria, tetanus, whooping cough, hepatitis B, polio and Haemophilus influenzae type b (Hib) vaccine
eighteen months of age – a booster in the form of a diphtheria, tetanus, whooping cough vaccine
four years of age – a booster in the form of a diphtheria, tetanus, whooping cough and polio vaccine
adolescents in secondary school (or age equivalent) – adolescents receive a booster dose of diphtheria, tetanus and whooping cough vaccine. The dose can also be given by the doctor or at a council community immunisation session.
Catch-up immunisations are also available free-of-charge for all children and young people under 20 years of age
The immunisations you may need are decided by your health, age, lifestyle and occupation. Together, these factors are referred to as HALO. View the HALO infographic to find out more.
Adult booster immunisation against diphtheria
Immunity against diphtheria reduces with time and further booster shots may be needed. A course of diphtheria-containing vaccine is recommended for anyone who has never been vaccinated.
Three doses are given at monthly intervals and two further booster doses are given 10 years apart. A diphtheria, tetanus and whooping cough booster is recommended for adults from 50 years of age and requires a GP prescription to purchase the dose.
Before diphtheria immunisation
Before immunisation, make sure that you tell your doctor or nurse if you (or your child):
are unwell on the day of immunisation (temperature over 38.5°C)
have had a serious reaction to any vaccine in the past
have had a severe allergy to anything
are pregnant.
Side effects of the diphtheria vaccine
Immunisations containing protection against diphtheria, tetanus and whooping cough and other infectious diseases are effective and safe although all medications can have unwanted side effects.
Side effects from these combined vaccines are uncommon and usually mild, lasting one or two days, but may include:
localised pain, redness and swelling at the injection site
occasionally, an injection-site lump (nodule) that may last many weeks but treatment is not needed
low-grade temperature (fever)
children can be unsettled, irritable, tearful, generally unhappy, drowsy and tired.
If a combined immunisation also contains the vaccine against polio (the six-in-one and the four-in-one vaccine), muscle aches may also be experienced.
Managing fever after immunisation
Common adverse events following immunisation are usually mild and temporary (occurring in the first one to two days after vaccination). Specific treatment is not usually required.
There are a number of treatment options that can reduce the side effects of the vaccine including:
Give extra fluids to drink.
Do not overdress children or babies if they are hot.
Although routine use of paracetamol after vaccination is not recommended, if fever is present, paracetamol can be given. Check the label for the correct dose or speak with your pharmacist, especially when giving paracetamol to children.
Managing injection site discomfort
Many vaccine injections may result in soreness, redness, itching, swelling or burning at the injection site for one to two days. Paracetamol might be required to ease the discomfort.
Sometimes, a small, hard lump (nodule) at the injection site may persist for some weeks or months. This should not be of concern and requires no treatment.
Concerns about immunisation side effects
If an adverse event following immunisation is unexpected, persistent or severe, or if you are worried about yourself or your child's condition after immunisation, see your doctor or immunisation nurse as soon as possible, or go directly to a hospital. It is also important to seek medical advice if you (or your child) are unwell, as this may be due to other illness rather than because of the immunisation.
Adverse events that occur following immunisation may be reported to the Victorian Surveillance of Adverse Events Following Vaccination in the Community (SAEFVIC) Line. SAEFVIC is the central reporting service in Victoria for any significant adverse events following immunisations. You can discuss with your immunisation provider how to report adverse events in other states or territories.
Rare immunisation side effects
There is a very small risk of a serious allergic reaction (anaphylaxis) to any vaccine. This is why you are advised to stay at the clinic or medical surgery for at least 15 minutes following immunisation in case further treatment is required.
If any other reactions are severe and persistent, or if you are worried, contact your doctor for further information.
In an emergency, call triple zero (000)
The emergency department of your nearest hospital
Your local council immunisation service
NURSE-ON-CALL Tel. 1300 60 60 24 – for expert health information and advice (24 hours, 7 days)
Maternal and Child Health Line (24 hours, 7 days) Tel. 13 22 29
Immunise Australia Information Line Tel. 1800 671 811
SAEFVIC Tel. 1300 882 924 – the line is attended between 9 am and 4 pm and you can leave a message at all other times
'4.2 Diphtheria' in The Australian Immunisation Handbook 10th ed., 2017, Department of Health, Australian Government.
National Immunisation Program Schedule , Department of Health, Australian Government.
Vaccine side effects , Department of Health, Victorian Government.
Diphtheria , Mayo Clinic, USA.
Adult/adolescent diphtheria, tetanus and pertussis , Department of Health, Victorian Government.
Diphtheria and tetanus immunisation information , Department of Health, Victorian Government.
View all immunisation
Immunisation Unit, Department of Health Victoria
Immunise Australia Program, Australian Government Department of Health and Ageing


Back in May, as part of a settlement, Spotify agreed to pay more than $112 million to clean up some copyright problems. Even for a service with millions of users, that had to leave a mark. No one wants to be dragged into court all the time, not even bold, disruptive technology start-ups.
On October 11th, the President signed the Hatch-Goodlatte Music Modernization Act (the "Act", or "MMA"). The MMA goes back, legislatively, to at least 2013, when Chairman Goodlatte (R-VA) announced that, as Chairman of the House Judiciary Committee, he planned to conduct a "comprehensive" review of issues in US copyright law. Ranking Member Jerry Nadler (D-NY) was also deeply involved in this process, as were Senators Hatch (R-UT) Leahy (D-VT), and Wyden (D-OR). But this legislation didn't fall from the sky; far from it.
After many hearings, several "roadshow" panels around the country, and a couple of elections, in early 2018 Goodlatte announced his intent to move forward on addressing several looming issues in music copyright before his planned retirement from Congress at the end of his current term (January 2019). With that deadline in place, the push was on, and through the spring and summer, the House Judiciary Committee and their colleagues in the Senate worked to complete the text of the legislation and move it through to process. By late September, the House and Senate versions had been reconciled and the bill moved to the President's desk.
What's all this about streaming?
One part, by far the largest change in terms of money, provides that a new royalty regime be created for digital streaming of musical works, e.g. by services like Spotify and Apple Music. Pre-1972 recordings — and the creators involved in making them (including, for the first time, for audio engineers, studio mixers and record producers) — are also brought under this royalty umbrella.
These are significant, generally beneficial results for a piece of legislation. But to make this revenue bounty fully effective, a to-be-created licensing entity will have to be set up with the ability to first collect, and then distribute, the money. Think "ASCAP/BMI for streaming." This new non-profit will be the first such "collective licensing" copyright organization set up in the US in quite some time.
Collective Licensing: It's not "Money for Nothing", right?
You "Can't Buy Me Love", so who is all this going to benefit?
In theory, the listening public should be the primary beneficiary. More music available through digital streaming services means more exposure —and potentially more money —for recording artists. For students of music, the new database of recorded works and licenses will serve to clarify who is (or was) responsible for what. Another public benefit will be fewer actions on digital streaming issues clogging up the courts.
There's an interesting wrinkle in the Act providing for the otherwise authorized use of "orphaned" musical works such that these can now be played in library or archival (i.e. non-profit) contexts. "Orphan works" are those which may still protected under copyright, but for which the legitimate rights holders are unknown, and, sometimes, undiscoverable. This is the first implementation of orphan works authorization in US copyright law. Cultural services – like Open Culture – can look forward to being able to stream more musical works without incurring risk or hindrance (provided that the proper forms are filled out) and this implies that some great music is now more likely to find new audiences and thereby be preserved for posterity. Even the Electronic Frontier Foundation (EFF), generally no great fan of new copyright legislation, finds something to like in the Act.
For recordings first published before 1923, the additional time period ends on December 31, 2021.
For recordings created between 1923-1946, the additional time period is 5 years after the general 95-year term.
For recordings created between 1947-1956, the additional time period is 15 years after the general 95-year term.
For works first published between 1957-February 15, 1972 the additional time period ends on February 15, 2067.
For the digital music services themselves, this statutory or 'blanket' license arrangement should mean fewer infringement actions being brought; this might even help their prospects for investment and encourage new and more innovative services to come into the mix.
This new legislation, now the law of the land, extends the history of American copyright law in new and substantial ways. Its actual implementation is only now beginning. Although five years might seem like a lifetime in popular culture, in politics it amounts to several eons. And let's not lose sight of the fact that the industry got over its perceived short-term self-interests enough, this time, to agree to support something that Congress could pass. That's rare enough to take note of and applaud.
This law lacks perfection, as all laws do. The licensing regime it envisions will not satisfy everyone, but every constituent, every stakeholder, got something. From the perspective of right now, chances seem good that, a few years from now, the achievement of the Hatch-Goodlatte Music Modernization Act will be viewed as a net positive for creators of music, for the distributors of music, for scholars, fans of 'open culture', and for the listening public. In copyright, you can't do better than that.


text:
let mongoose = require('mongoose')

mongoose.Promise =  global.Promise

module.exports =  (config) => {
	mongoose.connect(config.db, { useMongoClient: true })

	let db = mongoose.connection

	db.once('open', err => {
		if(err) {
			console.log(err)
		}

		console.log('MongoDB ready !!!!')
	})

	db.on('error', err => console.log(err))

	require('../data/User').seedAdminUser()
}

redpajama_set_name: RedPajamaGithub


text:
Filters: Author is Espedal, Heidi [Clear All Filters]
Espedal, H. Detection of oil spill and natural film in the marine environment by spaceborne SAR. Doctoral Thesis No. 24 207 (1998).
Johannessen, O.M., et al. COASTWATCH 95: Using SAR imagery for monitoring coastal currents, surfactants and wind fields. Proceedings for the 27th International Symposium on Remote Sensing of Environment Information for Sustainabilty Tromsø, Norway, organized by International Symposia on Remote Sensing of Environment (ISRSE) and the Norwegian Space Centre 127-130 (1998).
Espedal, H. Oil spill and its look-alikes in ERS SAR imagery. Earth Observation and Remote Sensing 5, 94-102 (1998).
Espedal, H., et al. Development of a natural oil seepage detection system. Phase 1 report to A/S Norsk Shell. NERSC Special Report no. 56. Confidential (1998).
Espedal, H. An ERS SAR slick discrimination algorithm. NERSC Technical Report No. 149 (1998).
Jenkins, A., et al. Intercomparison and improvement of SAR ocean imaging interaction models. Final report. NERSC Technical report no. 132 (1998).
Jenkins, A., Pettersson, L.H., Hamre, T. & Espedal, H. Metocean and Coastal Zone monitoring in Harbour Regions using Satllite Radar - COASTMON. WP2: Development of improved EO data product. COASTMON report No 2. NERSC Technical Report no. 156 (1998).
Kotova, L.L.A., Espedal, H. & Johannessen, O.M. Oil spill detection using spaceborn SAR; a brief overview. Proceedings for the 27th International Symposium on Remote Sensing of Environment Information for Sustainabilty Tromsø, Norway, organized by International Symposia on Remote Sensing of Environment (ISRSE) and the Norwegian Space Centre (1998).
Bessant, M., Johannessen, O.M., Jenkins, A. & Espedal, H. 8-Bits Data Storage Electronic System for Sea-surface Measurements. NERSC Technical report no. 137 (1997).
Pettersson, L.H., Johannessen, O.M., Korsbakken, E. & Espedal, H. Applications of satellite earth observation data for mapping of the marine environment of the coastal zones. Extended Abstract in proceedings from the UNESCO Symposium - Teaching Integrated Coastal Zone Management - Russian Hydrometeorological Institute, St. Petersburg, May 29. - 30 (1997).
Johannessen, O.M., et al. COASTWATCH '95: Using SAR Imagery in an operational system for monitoring coastal currents, wind, surfactants and oil spills. In proceedings Third ERS Symposium on Space at the service of our Environment Florence, 14. - 21. March, 1997, ESA SP-414 2, 1041-1048 (1997).
Johannessen, O.M., et al. COASTWATCH: ERS-1/2 SAR Applications of Mesoscale Upper Ocean and Athmospheric Boundary Layer Processes of the Coast of Norway. Proceedings from IGARSS 97 - A Scientific Vision for Sustainable Development, IEEE no. 97CH36042, Singapore 1165-1167 (1997).
Johannessen, O.M., Korsbakken, E., Samuel, P., Jenkins, A. & Espedal, H. COASTWATCH: Using SAR imagery in an operational system for monitoring coastal currents, winds, surfactants and oil spills. Operational Oceanography. The challenge for European co-operation, proceedings of the First International Conference on EuroGOOS, 7. - 11. October, 1996 234-242 (1997).
Espedal, H., et al. ERS-1/2 SAR Detection of Natural Film on the Ocean Surface. In proceedings of Third ERS Symposium on Space at the Service of Our Environment, Florence, Italy, 14. - 21. March, ESA SP-414 3, 1361-1366 (1997).
Sandven, S., et al. Intercomparision and Improvement of SAR Ocean Imaging Interactions Models. (1997).
Hamre, T. & Espedal, H. Operational use of Wind Data for Slick Detection. In proceedings of Third ERS Symposium on Space at the Service of Our Environment, Florence, Italy, 14-21 March, ESA SP-414 3, 1417-1422 (1997).
Hamre, T., Espedal, H., Sandven, S. & Samuel, P. Operational Use of Wind Data for Slick Detection and Verification in the ERS SAR Images. NERSC Special Report no. 47. Final Report to Tromsø Satellite Station (1997).
Jenkins, A., Johannessen, O.M., Korsbakken, E., Samuel, P. & Espedal, H. Quantitative Estimation of Upper Ocean Air-Sea Interaction Processes using Tandem (ERS-1/2 SAR) and Synergetic Instrument Combinations. In proceedings Third ERS Symposium on Space at the service of our environment, Florence, March 1997 (www. version only) (1997).
Jenkins, A., et al. Remote Sensing Applied to Operational Models - North Sea. Proudman Oceanographic Laboratory, Birkenhead, UK. , Report No. 49 (1997).
Johannessen, O.M., et al. A review of the possible applications of satellite earth observation data within EuroGOOS. Operational Oceanography, The challenge for European co-operation, proceed. of the First Int. Conference on EuroGOOS 7. - 11. Oct. 1996,The Hague, The Netherlands. Elsevier Oceanogra 192-205 (1997).
Espedal, H., Hamre, T., Sandven, S. & Samuel, P. Surface Slick Signatures in Semi-Closed Sea Areas (The Baltic Sea). Final Report to Tromsø Satellite Station. NERSC Special Report no. 48 (1997).
Espedal, H., Johannessen, O.M. & Knulst, J.C. Satellite detection of natural films on the ocean surface. Geophysical Research Letters 23, 3151-3154 (1996). Abstract
Johannessen, O.M., et al. Coastwatch´95: ERS-1/2 SAR Applications of Mesoscale Upper Ocean and Athmospheric Boundary Layer Processes of the Coast of Norway. Proceeding of IGARSS 96, 27-31 May, Lincoln, Nebraska, USA (1996).
Hamre, T., Espedal, H., Sandven, S. & Samuel, P. Operator s Manual for Slick Analysis. NERSC Special Report no. 37 (1996).
Jenkins, A., Johannessen, O.M., Samuel, P., Espedal, H. & Korsbakken, E. Quantitative Estimation of Upper Ocean Air-Sea Interaction Processes using Tandem (ERS-1/2 SAR) and Synergetic Instrument Combinations. Proposal to ESA, response to Announcement of opportunity for the scientific exploitation of the ERS Tandem Mission (1996).


text:
<?php

class Google_Service_Vision_GoogleCloudVisionV1p2beta1TextAnnotationDetectedLanguage extends Google_Model
{
  public $confidence;
  public $languageCode;

  public function setConfidence($confidence)
  {
    $this->confidence = $confidence;
  }
  public function getConfidence()
  {
    return $this->confidence;
  }
  public function setLanguageCode($languageCode)
  {
    $this->languageCode = $languageCode;
  }
  public function getLanguageCode()
  {
    return $this->languageCode;
  }
}


text:
Q: Use method of class without injecting in startup? I have a service ITokenService that will generate token. I have configured this service in my startup like:
services.AddSingleton<ITokenService, TokenService>();

Now I am injecting another custom provider that requires this token for initialization
services.AddScoped<IManagementApiClient>(provider => new ManagementApiClient("token", "YOUR_AUTH0_DOMAIN"));

now I want to pass the token generated from ITokenService to the token used in ManagementApiClient initialization. Is there any way to do that by creating another custom provider or by doing something else.
I have followed this link https://github.com/auth0/auth0.net/issues/179 but didn't understand how can I do this. Any help?

A: You can resolve the ITokenService from the IServiceProvider in the implementation factory delegate:
services.AddScoped<IManagementApiClient>(provider =>
    new ManagementApiClient(provider.GetRequiredService<ITokenService>().GetToken(), "YOUR_AUTH0_DOMAIN"));

I wonder though, why do you need a specific ITokenService for that? Won't retrieving the values from configuration be sufficient? For example:
public class Startup
{
    public Startup(IConfiguration configuration)
    {
        Configuration = configuration;
    }

    private IConfiguration Configuration { get; }

    public void ConfigureServices(IServiceCollection services)
    {
        services.AddScoped<IManagementApiClient>(new ManagementApiClient(Configuration["Auth0:Token"], Configuration["Auth0:Domain"]);

        // ...
    }
}

You can specify theses settings in appsettings.json:
{
  "Auth0": {
    "Domain": "your.domain.auth0.com",
    "Token": "your token"
  }
}

redpajama_set_name: RedPajamaStackExchange


text:
Group I's Webpage
[1] The Roman Empire
The Roman Empire: The Fall of the Roman Republic
The Roman Empire: Augustus and the Principate Period
The Roman Empire: The Fall of Augustus
[2] Early Age of Tiberius
Early Age: Tiberius Claudius Nero
Tiberius's Contributions as General
[3] Tiberius Julius Caesar's Rule
Tyrannical Acts of Tiberius – Destroying Augustus's Principate
[4] The Fall of Tiberius
The Fall of Tiberius: Sejanus
The Fall of Tiberius: The Provinces Remain Strong
The Fall of Tiberius: The Fall of Tiberius Caesar
[5] Works Cited
In order for us to better understand Tiberius and the legacy he left behind, it is necessary to review his life from all facets and angles. This includes Tiberius at a young age, and as he was growing up. Tiberius Claudius Nero was born on 16 November 42 B.C. to Tiberius Claudius Nero and Livia Drusilla. The exact date that he was born can be attributed to the writing of the historian Suetonius. Due to such massive connections of his parents to wealthy and integrated Roman houses, from birth Tiberius was set on a political life. However when Tiberius was only two years old in the year of 39BC after the old republic system of Rome using the Senate and Magistrates was toppled by the ambitious Octavian (Augustus), and an autocratic rule was established. This led to his mother Livia divorcing his paternal father Tiberius Claudius Nero and marrying Augustus. This made Tiberius the stepson of the future ruler of Rome and the most powerful man around.
After this bit of action, Tiberius' childhood was relatively uneventful until the death of his paternal father in 32BC. At this point he made his first public appearance at the funeral of his father and read his eulogy for all to hear. After this is when Tiberius really started stepping into the limelight. In 31BC after the battle of Actium, Augustus had shown himself to be the ruler of the Roman Empire. This made Tiberius the son to the head of state. Therefore in 29BC he took part in Augustus' triumph for the Actium campaign and sat next to Augustus in his triumphal chariot. Two years after this Tiberius was considered a man and Augustus led him into the forum as he donned the gown of manhood. Three years after that, at the age of 17, he became a quaestor and was given the option of standing for a praetorship or consulship five years before legally allowed by the law. Now that he was in the political game, he was sent by Augustus east to the Parthians in 20BC. These were the same Parthians who had captured several of the Roman eagles, and Tiberius oversaw their journey back to Rome. Upon arriving in Rome from the East, he was granted praetorian rank and in 13 BC he was named consul. It was around this time also that we was happily married to Vipsania Agrippina the daughter of Augustus's right-hand man, Vipsanius Agrippa. With Vipsania, Tiberius produced a son named Drusus.
In 12BC Augustus's right hand man Agrippa died and Augustus forced an unwilling Tiberius to marry his widow Julia, and divorce his
current wife Vipsania. This marriage was not a happy one, for Tiberius' heart belonged to Vipsania and he was completely banned from seeing her. Never the less, Tiberius' life kept marching forward and so did his duties and place in the state. He became an important general for the state and was elected consul again in 7BC and was granted tribunician power in 6BC. In principle he was the new heir to the Augustian throne after Agrippa died. However without warning in 6BC he announced a complete withdrawal from public life and decided to self exile himself to Rhodes.
This came as a huge shock to Augustus and he did a complete about face against Tiberius. He no longer considered him the heir and instead turned to others below him. Eventually Tiberius realized the folly of this journey to Rhodes and requested passage back to Rome. Augustus denied this passage every time. When Tiberius' powers ran out in 1 BC they were not renewed. However in AD 2 a ship came to Rhodes with news for Tiberius. The next successor Lucius Caesar had passed away by an illness. Thus Tiberius returned to Rome as a back up option in the list of heirs.
Following this however the next heir in line Gaius Caesar died of a wound sustained at a siege. Augustus was devastated, as his perfectly laid out plan of succession was ruined. Henceforth he called Tiberius out of private life and adopted him fully as his son, with the stipulation that he adopt Germanicus, his nephew, as his son. This was another attempt by Augustus to have a new line of heirs in case of disaster, and one that would have his own blood flowing through them. Now with Tiberius as the clear successor, he also received grants of proconsular power and tribunician power, and in AD 13 his proconsular power was made co-extensive with Augustus. This made them in effect co-rulers so that when Augustus finally died on 19 August A.D. 14, no one could question Tiberius' ascension to sole ruler.
Tiberius © 2020. All Rights Reserved.


Jane's career spans over 25 years in the public, community and private sectors. Originally a social worker, Jane's focus has always been on service management and design for people who are socially and/or economically disadvantaged. Jane also has post graduate qualifications in Social Policy and currently oversees customer service reform for Legal Aid NSW - putting the client at the centre of everything they do.


Content by tag "T.K. Blue"
Saxophonist and flutist T.K Blue's tenth album A Warm Embrace is an enchanting and elegant work with richly textured harmonies and captivating melodies. Even though not all of the tracks are strictly speaking ballads there is a sublime sense of poetry that runs throughout the record and is its prevailing and cohesive motif.
At a time when Hispanics are the dominant minority in the United States, The National Academy of Recording Arts & Sciences has decided to eliminate the Latin Jazz category. This list is posted in solidarity with those who demand that the category be reinstated.


There are many artefacts and fascinating documents on display at Newhaven Fort, but we have a wealth of information and articles that are not on display. Our collection includes thousands of individual objects ranging from weapons, uniforms and trench art through to documents, photographs and maps. The Fort library and archive holds an extensive range of books and other documents such as the Fort census returns up to 1901.


NEW DELHI: The Supreme Court on Wednesday reserved its ruling on the validity of panchayat documents in the ongoing process to update the National Registrar of Citizens as it heard a set of 19 petitions relating to it.
A division bench of the country's top court comprising Justice Ranjan Gogoiand Justice F Nariman heared the petitions onthe validity and competency of the panchayat certificates as supportive documents to update NRC.
It further heard a few other petitions relating to NRC. But did not cleared any ruling. The court is expected to pass the judgment on Thursday.
The top court, further, is expected to hear the Centre's petition for extending the deadline to July 31,2018 instead of December 31,2018.

SC reserves ruling on NRC documents

NEW DELHI: The Supreme Court on Wednesday reserved its ruling on the validity of panchayat documents in the ongoing process to update the National Registrar of Citizens as it heard a set of 19 petitions relating to it.

A division bench of the country's top court comprising Justice Ranjan Gogoiand Justice F Nariman heared the petitions onthe validity and competency of the panchayat certificates as supportive documents to update NRC.

It further heard a few other petitions relating to NRC. But did not cleared any ruling. The court is expected to pass the judgment on Thursday.

The top court, further, is expected to hear the Centre's petition for extending the deadline to July 31,2018 instead of December 31,2018.

This post SC reserves ruling on NRC documents was originally published on Assam Times.


Doug Leighton, VISA SVP Head of Community Accounts, stopped by the Studio Lounge to discuss contactless payments impact on credit unions and members in 2019. Doug also touched on financial inclusion programs at Filene Research Institute and how they are impacting credit unions, as well. Good stuff here from Doug. Check it out and let us know your thoughts.


I am not usually sad when a month is over, and although I am happy when November ends, this year I am sad because it was the best month of this year. For so many years, this month was my most hated month weather wise, because it's the most depressive month of the year, however, things have changed this year or should I say I have changed. Furthermore, I didn't want to write about the topic of depression publicly, but my emotions and thoughts want to storm out of me.
Depression is not a sickness of some crazy people anymore, it is the sickness of most people. We cannot all be crazy, but we can all make mistakes or break down from the problems in our lives. As a woman who suffers from PCOS I always had to fight with depression since I was 17, but writing became my therapy. I managed the depression periods myself, by changing something in my life for the better. When I had to apply for a new job, I was asked why I changed my workplace so often, but it was difficult to answer. The reason was that I didn't like the jobs anymore and became bored because I had learned everything I needed to, in which there is nothing more worse for me than stagnancy! 4 years ago, I started in a totally new field than before, where you constantly need to learn new things, working in a lawyer's office that dealt with people's debts. I had to talk with the debtors and send them letters and found it great, because I could advise them with their problems. I had good and bad times in my company, but I still regarded it as my second home, although I didn't realize how much I allowed my work to control my life. We were trained to find ways to get better, as well as never trusting others, and I had the pressure of becoming better each day. I worked 8 or more hours a day, went home, prepared dinner for myself and continued to work for another 4 to 6 hours online. I had no free time for many years and the last holiday I had was in 2002. I was a workaholic and I was never happy with my work, but I tried to remain calm whilst continuing to try hard. Then one day in July 2015 my team leader misbehaved towards me, it was just a normal check-up they do, so I had nothing to worry about, but this time, she was in a very bad mood and she chose me as the person to let her anger out on. The check-up was taking about an hour, but it ruined my life, all that I had achieved for myself regarding self-confidence was destroyed by her, and in the following week, I couldn't go to work due to terrible stomach pains. That pain never really went away, it was just getting weaker, then in October 2015 it was getting more worse, but silly me I kept on working and doing things for the plus size community. I never received a thank you from my company, nor from the people within the plus size community for all my effort. I was an idealist, but since last year I became a realist because my work created too much negativity in my life and when I got confronted by the negative people within the movement, I was constantly getting angry. Up until today, I still don't understand why people fight each other over petty reasons; growth is not possible with jealousy and hate. Forgive each other, as I have forgiven everyone, or it will destroy you!
The stress at work caused me to collapse in November 2015, and I was not able to work since then. Furthermore, I was advised to never go back to this workplace because the effects of it on my soul might cause more terrible health problems for me. I gave too much importance to this job and ignored the down sides, but today I know this was my mistake. It was not my mistake to be the one who had to handle the verbal abuse of my team leader, that was her own fault and she must live with the consequence of her behaviour. It was too late for me to get out of this without any consequences, and I was in hospital several times, had tons of check-ups and was only surviving on painkillers in times of strong pain. I kept on fighting and doing my posts as usual, no matter how bad I felt; but I didn't realize what was not right with me until my doctor said I have a depression. Then this year my old page partner Norman Spee became a member of my team again, and a few months later I had another member named Justin J. White who writes the most amazing articles, plus things got better within time. Nevertheless, my own life was not working well, on some days I was not motivated, and on other days I could just walk around with a sad face, because I couldn't even cry anymore; on other days, I could at least go out for a short walk and then were the days where I was scared of leaving the bed, because there could be something out there. There was nothing even though I feared no single thing. I tried out psychopharmaceutical, but I gave it up after a few days since I couldn't handle them well, and today I am happy that I didn't take them again. The painkillers for all my pain were hard enough; it is safe to say that the year 2016 was horrible and I had to realize that this is not just one of the less harmless depressive moods I had before, this was a real problem that could have cost my life. Unexpectedly, my first bit of help came from books of a certain author. I don't want to mention him yet, because his books might not only help me but might also help my family. My second help was God! It's that simple! Well, it's not only God alone that changed it, it was also my understanding of the world and the humans. I see many things from a different perspective than before, I had to deal with people who let their anger out on me everyday. This didn't hurt me, because I know I am not responsible for their misery; but I lived a life that was ruled by mortification, people humiliated me for no reason and blamed me for their own problems. My team leader was the worse one out of all of them, because she was not happy with her life; the mortifications that I received and those that I gave to others caused me to live an unhappy and angry life. I learned that to receive love, you must give love and if the people try to hurt you then let them do that, because it will only affect them!
Interestingly, not only did I had to review everything, but the whole US nation did too. The win of the new president was meant to be an eye opener for millions as it was for me, and 2016 was not an easy year for all of us, but it is what we need. 2016 is God's way of testing us, it is his way of helping us to protect us from the future. I know today that having a sickness is a blessing and I thank God for this, because only through this I managed to become stronger, wiser and more sensitive than ever before. To achieve this, it is important to review your life, your actions, your thoughts, your reactions and your own behaviour. Look for patterns, look for the cause and effect and start to analyse your life and the lives of your family. I learned that the worst thing we can do is to hurt someone; it doesn't have to be me who got hurt, it could also be one of my parents who got hurt by a family member or by their partner. Unfortunately, this negativity stays in us and it is very difficult to find healing, unless you try to find it in God. I think that religions, no matter how much they seem to separate us, were given to us to help us, and you don't need to become the perfect Jew, Muslim or Christian, but you need to learn from your mistakes. You need to forgive yourself, because if God can forgive you then so will you. Accept your mistakes and learn to love yourself with all your failures, because you are a beautiful soul!
It was hard for me to understand, why he helped me to stay alive, it would have been easy for him to take my life, but he chose another path for me. Is it because of the help you get from me and my magazine? I don't know. I can only guess that I still need to achieve a few things for him. It might sound grotesque, but facing my own end was helping me the most, if I should have died, then he would have made sure it happened; but he would rather help me to survive and grow. I am not scared of dying anymore, because I know my soul will never die. I had my first good time this year in June and July, when I was in a rehabilitation facility; I couldn't believe how many people suffered from depression like me. Being there without any contact of the outer world helped me to rethink my life. I realised which mistakes I made and I understood the effect of the cause of my life! The effect is very individual and you need to rethink it all, but what you need to do the most is pray to God; I have never felt such a huge amount of peace and happiness after I realised that God still loves me. You may think that you cannot achieve anything in life because others told you that or because they also think low of themselves; but this is not true. You can achieve everything you want to, if God wants you too. This is not just a saying, this is my honest experience. You need to understand that suffering is part of life, our mind learns from mistakes, but our soul learns from suffering, and God is the one who allows the suffering in your life because he loves you. This might make some people angry, but his love is the reason for your suffering, and yes, some people suffer more than others. I can't change that, I can only try to understand that without the depression and the stomach pains I wouldn't exist today, because my soul changed for the worst. This problem is solved now, but it doesn't mean that it cannot happen again, we are as healthy and as happy as our thinking and behaviour; we need to understand that there is much more than a body and brain. The most precious thing about us is our soul and we don't protect it at all, the soul is the energy that runs through you and this energy creates your life situation. God knows that and therefore I am happy to realise that he loves me so much that I had to go through a whole year of suffering to improve my life!
Besides posting I tried to organise new articles during the year. I know I didn't answer many emails and I kept many articles back, but I will get back to those ideas when I feel better. It was very difficult to manage them before, it was difficult to keep on working on my first issue, which I started to work on last summer before the problems started. I couldn't write nor evaluate what kind of problem I exactly had. I always said I didn't see things clear because it's like looking out of a window with a curtain restricting your view. I was very proud of myself that I went to London last weekend, it was planned for many months in advance, but I wasn't sure if I would manage. It was not easy and I still had to rely on pain killers, but it was the second-best experience of this year. The best one is private and since family comes first for me, it was my best experience. Nevertheless, traveling to London and getting to know new people was not less amazing, it was like meeting a new family. I must say that the organiser of Ms Curvaceous UK contest and his family made sure I was all well, which is the most important thing for me. Traveling there and meeting new people was a difficult challenge for me, but I am happy that I dared to do this. This is how I was before, I embraced the challenges; achieved my goals and I was proud of myself, and for about 2 years prior, I didn't achieve any of my goals and whenever I tried to do something new it failed horribly. You should never give up, you should always keep on challenging yourself, there will be many failures and many people will hurt you, but you should never allow them to get too close to you; these people might have a whole bunch of problems, because people who speak and think negatively have a lot of unsolved issues within themselves. Therefore, it's better to stay away from them when you are not strong enough. I couldn't even speak to some of my oldest friends because I was not strong enough, things have changed since I managed my travel and jury challenge in London, and I am a lot more positive right now. I can plan, I can organise again, and I can cry as much as I can smile at the same time. I am re-connected with my soul and with mother earth!
When I was younger, we travelled back home to Romania during the summer holidays. On one of these trips I asked my Romanian grandmother 'what does God mean to you?' She answered 'Love and Hope.' I didn't understand back then what these simple words meant to her. We always regarded my grandmother as a crazy religious fanatic in some ways, because she would do everything for her Orthodox church, especially giving them more money although they already had tons of that. It made me angry back then, but today my perspective has changed. I finally understand her and I know what she went through, I also understand what God's love is and how amazing the feeling of hope he gives you is. My brother learned this at a very young age and even though I followed him to church I didn't realise it until I was live on the razor-edge. I will never forget the feeling of the needle in my arm whilst I was in the hospital feeling helpless knowing that only God could help me. With his help I also survived the most difficult year of my life!
You must really believe that if other people want to do you wrong, then it will only be them who suffer the most – not you!
You must think, speak, behave and suffer in a positive way!


The Reading Rangers were responsible for organising a 'Book Cafe' for each Key Stage to be held on different mornings. We invited parents and carers to join us in with a whole class read and related activities. We had so much fun.
Please click on the links below to see your Key Stage.