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Professor Alexander Winchell, Geologist | Photograph | Wisconsin Historical Society
Professor Alexander Winchell, Geologist
Carte-de-visite portrait photograph of Alexander Winchell (1824-1891), former state geologist of Michigan and professor of Geology and Paleontology at the University of Michigan. Winchell made efforts to reconcile the conflict between evolution and religion in his writing and oratory. Shown here sitting in three-quarter profile. "1869, died 1890," has been handwritten at the bottom. Winchell has signed this card, "Yours truly, A. Winchell."
Creator Name:
Revenaugh & Co.
Lapham, Increase Allen, 1811-1875 : Increase A. Lapham papers, 1825-1930
Original Format Type:
Original Format Number:
PH 24
Original Dimensions:
Photography studio credit on the back reads, "Revenaugh & Co., (Successor to Geo. C. Gillett,). Photographie and Art Studio, Kelley's Block, East Huron St., Ann Arbor, Mich." From album of portrait photographs collected by Lapham depicting scientists and artists, ca. 1860-ca. 1875. Images include portraits of geologists, botanists, sculptors, and authors. First of two portraits depicting Winchell in Lapham's ablum. Refer to WHI Image ID: 47834 for the other.
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A mystery fever is stalking children in Bihar's Muzaffarpur district. As many as 47 children succumbed to the disease by June 29. Seventy-nine others, admitted in the two government hospitals in the district, were either undergoing treatment or had been discharged after treatment.
The disease has been around in Muzaffarpur and adjoining areas for a decade, but it is only now that the health authorities are making a serious effort to deal with it. All the patients suffered from inflammation in the brain, muscle stiffness and high fever that rendered them unconscious. "As the disease and the agent causing it remain unidentified, the children were given only symptomatic treatment," says Braj Mohan, head of paediatrics department at Sri Krishna Medical College and hospital in Muzaffarpur.
The disease that occurs in June and subsides during monsoon was for long thought to be Japanese encephalitis because the symptoms were the same.
This was ruled out when Patna's Rajendra Memorial Research Institute (RMRI) and Pune's National Institute of Virology (NIV) ran tests on samples of cerebral spinal fluid and blood collected from the patients. "The samples tested negative not only for Japanese encephalitis, but also for Chandipura encephalitis and Nipah encephalitis viruses," says Pradeep Das, director of RMRI. The institute forwarded the samples to NIV for further characterisation. But NIV made no headway and has now collected brain tissue and urine samples and rectal and throat swabs from the patients for further tests.
A Union health ministry team that visited Muzaffarpur in the last week of June had termed the disease encephalitis. I P Choudhary, associate professor at the paediatrics department of Safdarjung Hospital in Delhi, reportedly said that "every symptom of the disease is matching with encephalitis; only the form is not known". Details will be known after NIV releases its test reports.
Earlier studies by NIV were limited in scope. Tests conducted by it during a couple of earlier outbreaks did not find viral cause for the disease.
"Last year RMRI tested some samples of blood and cerebral spinal fluid. The tests were conducted only for Japanese encephalitis virus which was not found," says S K Aman, deputy chief malaria officer with the Patna health department. That year, 21 children died of the fever. The data for previous years is not available. "We did not compile any data," says A P Singh, civil surgeon, at the district hospital.
Vipin M Vashishtha, paediatrician at the privately managed Mangla Hospital and Research Centre in Bijnor, Uttar Pradesh, says it is this narrow, non-serious attitude of the Muzaffarpur authorities that has resulted in high morbidity over the years. "We are missing the larger picture," he says. Inflammation of the brain does not necessarily indicate viral affliction. It could be a stroke or toxin-mediated encephalitis. He cites an example from Saharanpur district. A similar mystery fever gripped the district for 15 years. The cases were treated as Japanese encephalitis until he identiied the real culprit in 2007—a toxin from Cassia occidentalis, a shrub common in the region. Vashishtha says the authorities should adopt a multidisciplinary approach to identify the cause of the disease. Tests should also be conducted for presence of bacteria and fungi, he adds.
Bihar's director-in-chief of health Surendra Prasad says the administration is committed to finding the cause. "Tests are being conducted and all 63 villages affected by the disease are being fumigated to kill vectors (mosquitoes)," he says.
With the onset of monsoon, incidence of the disease has declined. It is feared that the problem may be put on the back burner, like it was done earlier, till the disease returns next summer.


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Tax Briefcase
Measures to promote technology transfer in Vietnam
Technology transfer could escalate technology absorption and productivity growth at less cost and risk. The Vietnamese government has been stepping up efforts and improving policy formulation to promote and support transfer, mastery and development of foreign technology in Vietnam to narrow the gap in technology qualifications and capacities with developed countries around the world.
Transition to high-tech manufacturing, integration into the global value chain and increasing the skilled workforce will lead to sustainable development of the country. Preferential policies are developed to create favourable conditions for technology transfer into/within Vietnam.
Forms of Technology transfer: The transfer of a technology can be implemented via the following forms:
An independent technology transfer contract;
A part of technology transfer in the following cases:
Investment project;
Capital contribution by technology;
Franchise agreement;
Transfer of industrial property rights;
A contract for purchase and sale of machinery or equipment to which the transfer of a technology is attached.
Other forms of transfer of technology as stipulated by law.
Registration of Technology transfer
Technology transfer agreements are subject to compulsory registration with the State Management Agencies of Science and Technology, except for restricted technology transfers which have already been granted specific permit.
If the technology is transferred from overseas or from a Vietnam based company to another Vietnam based company, the transferee is responsible for the registration. Otherwise, if the transfer is from Vietnam to overseas, it is the transferor's obligation.
Having the Technology Transfer Registration Certificates is one of the prerequisite for receipt of available supports and incentives.
Fund aids in Technology transfer
The National Technology Renewal Fund has been established to support enterprises in forms of loan with preferential interest rate, interest rate subsidy, loan guarantee, and financial support. Enterprises whose business activity engages in below technology transfers can be eligible for this fund:
Enterprises engaging in technology transfer which are in the category of encouraged technologies;
Technologies promoting the development of agriculture, forestry and fisheries in rural regions, mountainous regions and areas with difficult or extremely difficult socio-economic conditions;
Technology incubation, science and technology business incubation, decoding technology; and
Training of science and technology personnel in service of technology transfer.
Tax incentives for Technology transfer
Enterprises engaged in technology transfers in Vietnam can expect to receive tax incentives as follow:
Exemption of import duty is applied to imported goods directly in use for technological research, development or renewal, including machines, equipment, components, supplies and means of transport that cannot be domestically produced together with scientific documents, books and newspapers.
Technology transfer is not subject to value added tax ("VAT"). If a contract of technology transfer is associated with a transfer of machinery/equipment, the value of transferred technology is not subject to VAT.
Incomes from transferring encouraged technology to organization/individual in geographical area with particularly difficult socio-economic conditions will be entitled to tax exemption.
Enterprise that transfers encouraged technology to organization/individual in areas with difficult socio- economic conditions is entitled to 50% reduction of payable corporate income tax ("CIT") calculated on incomes from technology transfer.
For more information on the definition and tax implications relating to technology transfer, please refer to our article "Technology Transfer Transactions in Vietnam – Potential Tax Risks" published on Bloomberg dated 30 September 2019[1].
[1] https://news.bloombergtax.com/daily-tax-report-international/insight-technology-transfer-transactions-in-vietnam-potential-tax-risks

redpajama_set_name: RedPajamaCommonCrawl


text:
Battle of the Bands showcases student music groups
Update November 21, 2011 in FEATURE, NEWS Tagged Dow High News, Dow High Students, Feature Stories, News Stories, Student Activities Dow High - 3 Minutes
By Megan Bartlett & Mary Husser
On Oct. 11, many DHS students attended and performed in the Battle of the Bands, which is put on every year with the help of social studies teacher Ric Shahin. There were five acts, two of them being bands with three or more members.
Senior Jack Thompson opened with his cover of the song "Hallelujah." Thompson has been playing his acoustic guitar and singing in BOTB since his sophomore year. He appreciates that his guitar playing has improved over the years, but is unsure of whether or not he will play in the upcoming spring BOTB. While he enjoyed the event, he was perplexed by how few people showed up.
"At this point I have no idea what we could do," Thompson said. "We've advertised so much."
Junior Steven Klier, a guitar player and vocalist, got together with fellow juniors Tyler Sian and Matt Cassiday to form the band We Had Options. Klier also performed a few acoustic songs solo, and has now played for two years in a row. He is thankful for the opportunity to play in BOTB, and for the stage experience it provided.
Seniors Danny Hill and Leah Spaulding also performed together. Hill approached Spaudling early on and asked if she wanted to work as a duet, and she accepted. Both sang while Spaulding played piano and Hill played acoustic guitar. One of the songs they performed was "Home" by Edward Sharpe and the Magnetic Zeros. She participated last year, but had a much different experience this time around.
"Last year was different, I was only singing, but this year it was me and Danny, so I got to showcase my talent a little bit more and actually play piano. I do think I did a little better," Spaulding said.
Spaulding feels that having something to work toward to makes performing a lot easier and believes more people should come to BOTB next year.
"Something that is important to you makes you want to try harder and gives you a reason to sit down and practice and actually do better," Spaulding said. "I wish more people would come. It's people in your school, going on stage, and that's something hard to do. People should be there to at least watch them."
Senior Morgan Wynne has sung in BOTB for three years now, and also feels it has helped her to improve as a musician.
"[Battle of the Bands] helped me meet a lot of new people and I've learned a lot about forming a band and working with others, and the confidence to be a better performer," she said.
Wynne also feels that the outcome this year was an improvement from last year, but could still be better. She suggests that DHS should get others from the community involved.
"There were some people from Midland High there, so maybe we could advertise more at Midland High, or maybe in the Midland Daily News to get more people involved," Wynne said.
Whiteout, a band with juniors Kenny Grove, Eric Drenckpohl, Nathan Schell and Daniel Engwis was formed a while back and performs in BOTB each year.
Grove enjoys getting out with his band and playing music he likes in front of people from DHS, but is also concerned with how many few people showed up to watch the performers.
"I really don't know if there's anything more that could be done. It was already on the announcements every day, there were posters around the school, so I guess just word of mouth is the only way to get more people to come," Grove said.
"It was a great experience that I was very fortunate to take part in, and I look forward to doing it again," Grove said.
Photo Recap:
See images from the 2011 version of this Dow High Tradition!
https://update.midlandps.org/2010/11/2240/
Previous: Colleges visit DHS
Next: NHS and Key Club partner up to organize canned food drive
Christmas: A big holiday with big traditions


text:
<?php

namespace groupe\JeuxBundle\Entity;

use Doctrine\ORM\Mapping as ORM;
use Symfony\Component\Validator\Constraints as Assert;

/**
 * Patate
 *
 * @ORM\Table()
 * @ORM\Entity(repositoryClass="groupe\JeuxBundle\Entity\PatateRepository")
 */
class Patate
{
    /**
     * @var integer
     *
     * @ORM\Column(name="id", type="integer")
     * @ORM\Id
     * @ORM\GeneratedValue(strategy="AUTO")
     */
    private $id;

    /**
     * @ORM\OneToOne(targetEntity="mng\UserBundle\Entity\User")
	 * @ORM\JoinColumn(onDelete="CASCADE")
     */
    protected $user;

    /**
     * @var \DateTime
     *
     * @ORM\Column(name="datetime", type="datetime")
     */
    private $datetime;

    /**
     * @ORM\ManyToOne(targetEntity="groupe\JeuxBundle\Entity\Objets", inversedBy="patate")
	 * @ORM\JoinColumn(onDelete="CASCADE")
	 */
    protected $malus;

	public function __construct()
	{
		$this->datetime = new \DateTime;
	}

	public function __toString()
	{
		return $this->id;
	}

    /**
     * Get id
     *
     * @return integer
     */
    public function getId()
    {
        return $this->id;
    }

    /**
     * Set datetime
     *
     * @param \DateTime $datetime
     * @return Patate
     */
    public function setDatetime($datetime)
    {
        $this->datetime = $datetime;

        return $this;
    }

    /**
     * Get datetime
     *
     * @return \DateTime
     */
    public function getDatetime()
    {
        return $this->datetime;
    }

    /**
     * Set malus
     *
     * @param \groupe\JeuxBundle\Entity\Objets $malus
     * @return Patate
     */
    public function setMalus(\groupe\JeuxBundle\Entity\Objets $malus = null)
    {
        $this->malus = $malus;

        return $this;
    }

    /**
     * Get malus
     *
     * @return \groupe\JeuxBundle\Entity\Objets
     */
    public function getMalus()
    {
        return $this->malus;
    }

    /**
     * Set user
     *
     * @param \mng\UserBundle\Entity\User $user
     * @return Patate
     */
    public function setUser(\mng\UserBundle\Entity\User $user = null)
    {
        $this->user = $user;

        return $this;
    }

    /**
     * Get user
     *
     * @return \mng\UserBundle\Entity\User
     */
    public function getUser()
    {
        return $this->user;
    }
}

redpajama_set_name: RedPajamaGithub


Located at 305 N Main St, the Blue River Bistro exhibits a seventy bottle wine list offering twenty wines by the glass. Be sure to swing by during the week for live jazz and blues music from 5pm – 10pm.
Located at 113 S Main St, Modis offers a varied wine list with 22 reds and 22 whites both available by the glass and bottle to fit any budget. While you're there, don't skip snacking on the amazing happy hour and appetizer menu.
Located at 137 S Main St, Relish offers over a dozen wines by the glass and an impressive list of over 200 bottles. With some of the highest rated meals in Breckenridge, it'd be a shame not to go ahead and make a dinner reservation while you're thinking about it.
Located at 500 S Main St, Park and Main offers great meals alongside a wine bar with fair prices. With over 25 wines to choose from you'll find prices range from $3 to $7 per 100ml.
One of the best spots to relax after a day on the slopes (or during a day "off" the slopes) is the Living Room at One Ski Hill at the base of Peak 8. The Living Room offers a full restaurant and bar in a casual and inviting style. Try one of the many glasses or bottles of wine on a plush sofa or chair by yourself or with your family.
We toured the town, tasted the reds, sampled the whites, and even confirmed our thinking by scouring online reviews. If you're looking for great wine in Breck you're in for a treat.
This was one tough article to research!


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'The Bachelor': Sydney Hightower Turned Off the Comments to Her Instagram Posts After the Show Drama
Lauren Weiler
[Spoiler alert: The ending of The Bachelor Season 24, Episode 3 revealed.]
While Hannah Brown's season of The Bachelorette was a wild ride, Peter Weber's season is also delivering on the drama. While Brown made a brief appearance at the beginning of the season, that's far from the craziest thing that's happened yet. Now, all eyes are on Sydney Hightower, as she insinuated another contestant, Alayah Benavidez, wasn't being 100% truthful with Weber regarding who she truly is.
The whole debacle has Bachelor fans and contestants choosing sides. And while plenty of folks are now defending Benavidez's character, it seems Hightower doesn't want to hear about any of the drama on social media. The contestant posted a few new photos to Instagram, but she turned off the comments. Here's what happened.
Sydney Hightower questioned Alayah Benavidez's authenticity on 'The Bachelor'
Post workout, good lighting , Agua in a box..worth a pic . . . . .
A post shared by SydneyNicole (@sydneynicolehigh) on Sep 12, 2019 at 10:21am PDT
While we like to think all of the women competing for Weber's love on The Bachelor are here for the right reasons, there's always the chance that that's not the case. As we saw on Brown's season of The Bachelorette, Jed Wyatt was allegedly on the show primarily to advance his music career. And since Weber saw all of that go down first-hand, there's no doubt he's worried.
During Season 24, Episode 3, Sydney Hightower pulled Weber aside to tell him how she really feels about Benavidez. Hightower claimed Benavidez appears to turn into a whole different woman when the cameras are around, and she worried that the pageant queen was totally fake.
Chaos ensued after, as Weber then approached the other women in the house about Benavidez's personality. And contestant Victoria Paul seemed to seal Benavidez's fate when she told Weber that Benavidez asked her not to tell producers they knew each other before The Bachelor.
Benavidez is receiving a ton of support from outsiders
Boarding my @delta airlines flight back home to San Antonio…. and I'm expecting some turbulence… Seems like an appropriate enough way to watch tonight's episode of The @bachelorabc ♀✈ Buckle up ladies and gentleman, sh*ts about to go down. #Prayforme #cryingiscool #Delta #deltaairlines #thebachelor #bachelorabc #turbulance #bachelornation
A post shared by Alayah Benavidez (@alayahbenavidez) on Jan 20, 2020 at 4:01pm PST
Weber noted he had a strong connection with Benavidez from the start. But the drama proved to be too much, as he sent her packing. Given what we've seen from the previews, it looks like Benavidez returns to set the record straight about her authenticity. But in the meantime, she's receiving an outpouring of love and support from her fans on Instagram.
"You didn't deserve that treatment from Sidney. I have so much respect for you," one of Benavidez's followers commented on her Instagram post.
"Sydney had no right to question you like that!!! Keep being you, girl!" another added.
"Alayah! Sydney just mad she lost the pillow fight to you!!! Keep going she just wants the confidence u have," yet another fan commented.
Hightower turned off her Instagram comments after the episode aired
Sydney Hightower on Peter Weber's season of 'The Bachelor' | Eric McCandless via Getty Images
With all the support Benavidez received, we wouldn't be too surprised if Hightower was also getting some hate on the 'gram. While there are plenty of Bachelor fans who likely agreed with Hightower's assessment of Benavidez's demeanor, it seems Hightower wants to take herself out of the Instagram drama completely.
On Jan. 16, Hightower posted a modeling shot of her to Instagram with the caption, "Pasión" — but the comments are turned off. She then added another photo on Jan. 21 showing her in front of a mirror with the caption, "Today was a good day." Oddly enough, this post doesn't allow for public comments, either.
The last post on Hightower's Instagram that allows for comments was added on Jan. 13. And it looks like her followers are sending her love on this post, too.
As one follower noted, "since your comments are off on your new post i'll just tell you here that I love you."
And another wrote, "I love how calm and honest you are didn't like that peter called you out in front of the girls, but you handled it well. And you're gorgeous!!"
We're hoping Hightower reenables the comments on her future Instagram posts. Perhaps after the drama has passed, she'll allow it.
Check out Showbiz Cheat Sheet on Facebook!


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Exams and visits
FECHROMOCYTOMA: causes, symptoms and therapy
Testlevels - Illnesses
FEOCROMOCYTOMA
Pheochromocytoma is a catecholamine-producing tumor (adrenaline and noradrenaline) and is a rare cause of hypertension: however, its recognition is extremely important as the disease is susceptible to resolutive surgical therapy. It is a tumor involving cells of neuroectodermal derivation, that is, coming from the neural crest; some of these, during embryonic development, undergo migration in different parts of the body, where they constitute areas of chromaffin tissue (so-called because of its affinity for chromium salts).
These cells are found mainly in the adrenal medulla, but also at the level of the paragangli, structures located near the ganglia of the autonomic vegetative system: these are generally very small areas, which however in some locations, for example in correspondence with the mesenteric artery superior or some sympathetic branches, can give rise, in the course of embryonic development or the first years of life, to larger accumulations, such as the so-called Zuckerkandl organ, normally destined for atrophy.
Tissue of this type is also found in certain sensitive areas of the arterial system, such as the carotid glomus; but there can be chromaffin islands, often very small, in the most diverse locations. Tumor growth can occur from any of these nuclei; in 90% of cases the tumor is localized in the adrenal medulla, in 10% in the paraganglia, heart, bladder, prostate, ovaries. In the latter cases, the tumor is also called paraganglioma. The peculiarity of these tumors is that they maintain the ability to secrete catecholamines (adrenaline and noradrenaline) starting from the tyrosine substrate, and therefore to induce a stimulation of the alpha and beta-adrenergic receptors.
The exceptions are paragangliomas derived from the parasympathetic ganglia of the head and neck, which are not chromaffin and are often not functional, posing only problems of expanding mass. These tumors, often located in the carotid body and glomus, are also called chemodectomas. The prevalence of secretion of one or the other substance varies from tumor to tumor: in general, adrenal tumors produce adrenaline more frequently, since the cells of the adrenal medulla are more easily supplied with the methylating enzyme necessary to convert the norepinephrine into adrenaline. In this case, however, the associated secretion of adrenaline and noradrenaline is usual, while the prevalence or secretion of adrenaline alone is exceptional. On the other hand, extrasadrenal tumors produce norepinephrine more easily.
The secretion of one or the other amine, as we will see later, conditions the symptoms and some of the characteristics of the blood pressure trend. The feedback, at the anatomical table, of pheochromocytomas it is estimated at around 1 case in 1000, higher than the clinical frequency of the disease which is around 0.1% in the hypertensive population. While in most cases it is a single benign adrenal neoformation, in 10% of cases we are faced with a malignant form, in 10% with an extra adrenal form and in another 10% with bilateral or multiple neoformations.
Causes of pheochromocytoma
Since these are cancers, the etiology is unknown. In a minority of patients, however, hereditary influences are present: in fact, a number of pheochromocytomas occur as part of complex hereditary disorders, transmitted as an autosomal dominant trait with high penetrance. In the 66% of the latter it is an isolated pheochromocytoma, rather commonly multiple or malignant. Otherwise, pheochromocytoma can occur in the context of a condition called multiple endocrine neoplasia (and commonly abbreviated to MEN, Multiple Endocrine Neoplasia from the initials of the name of the disease in English), characterized by the simultaneous presence of several endocrine tumors.
Pheochromocytoma also occurs in 10% of cases of neurofibromatosis, an always hereditary condition characterized by the presence of numerous fibroids and neuromas, especially evident in the skin. Among the forms of pheochromocytoma transmitted hereditary, lastly we remember the association with von Hippel-Lindau disease (vascular malformations of the retina and cerebellum). Recently, important advances have been made in identifying the genes that affect a predisposition to pheochromocytoma and paragangliomas. In fact, four genes have been identified that predispose to these tumors.
The first, called RET, is a proto-oncogene which, if subject to a mutation that activates it, causes a constitutive activation of the receptor tyrosine kinase. Consequently, the parafollicular cells of the thyroid that produce calcitonin and the chromaffin cells of the adrenal medulla undergo hyperplasia with a high frequency of subsequent neoplastic transformation. Mutations in the RET gene are associated with a particular variant of MEN (Multiple Endocrine Neoplasia), called MEN-2 (and distinguished in a MEN-2A which combines medullary thyroid carcinoma and hyperparathyroidism and in a MEN-2B, in the which also have a particular constitutional habit, called marfanoid (2), and multiple neuromas on the mucous membranes).
In this case the probability of developing a pheochromocytoma is about 50%. The second gene, called VHL, is a tumor suppressor gene which, if inactivated by a mutation, tends to cause von Hippel-Lindau syndrome which, as already mentioned, is characterized by retinal and central nervous system hemangiomas ( but also from the propensity to develop pancreatic and renal cysts and renal carcinomas). In this case the risk of developing a pheochromocytoma is 10-20%. Finally, more recently, two other genes have been identified, called SDHD and SDHB which, if mutated, predispose to the development of carotid body tumors. Neurofibromatosis is not dependent on mutations in any of these four genes and the frequency of its association with pheochromocytoma is low (around 1%). The general idea is that pheochromocytoma, when sporadic and without a family history, depends on a somatic mutation of one of the predisposing genes and in other cases on a mutation in the germline.
In the past it was claimed that the alterations in the germline, conditioning the onset of pheochromocytoma in the context of complex hereditary disorders, were present in the 10% of cases of this disease. A recent investigation carried out in a large cohort of apparently sporadic pheochromocytoma cases (Neumann et al., 2002, cited by Dluhy, 2002) has instead shown that about 25% of the cases studied had a mutation in the germline of one of the four susceptibility genes. The fact that the cases studied apparently had no signs of the complex diseases associated with these mutations is not surprising, as their manifestation can be partial, late or even completely missing. However, the lesson from this study is that when a pheochromocytoma is encountered, a clinical study will always be appropriate, even with particular investigations in search of possibly associated conditions and that these should be extended to family members. In the future, a genetic analysis will in any case be appropriate in these patients.
Pathophysiology of pheochromocytoma.
The clinical signs of the disease are determined by the production of catecholamines, adrenaline and / or noradrenaline by the tumor. Noradrenaline has a prevalent activity on alpha-adrenergic receptors and its action on the cardiovascular system is basically reflected in a constriction at the level of the arterioles, with a consequent reduction in the average arteriolar radius and an increase in blood pressure. Adrenaline acts on both alpha and beta -adrenergic receptors. The stimulation of the latter causes a vasodilation of the muscular arterioles, with an antihypertensive effect.
However, adrenaline plays an important action in the heart, as the activation of beta-adrenergic receptors in this site causes an increase in the frequency and strength of contraction of the heart, with significant effects on blood pressure levels. The prevalence of secretion of one or the other sympathetic amine therefore conditions the symptoms reported by the patient. Often the release of catecholamines into the blood (see below) can have exceptional increases and hypertension can be episodic.
When it is secreted above all adrenaline, may occur, at the same time as the pressure increase, crises of malaise characterized by vasomotor phenomena, sweating, headache, tachycardia, fine tremors and feelings of anxiety or distress (the latter effects are due to the action of adrenaline on the central nervous system) . In some cases, orthostatic hypotension may occur alongside or instead of hypertensive episodes.
This can occur in the case of tumors that produce very large quantities of adrenaline, due to a peripheral action that is contrary to hypertension, and an extreme tachycardia that conditions a decrease in cardiac output, due to a reduction in diastolic filling time. Hypotensive episodes can also occur following so-called "catecholaminic storms", paroxysmal releases of high quantities of these hormones, as a consequence of hemorrhagic necrosis in the context of a pheochromocytoma. In such cases cardiocirculatory phenomena may be particularly evident due to a direct damaging action of catecholamines in extreme excess on myocardial cells, and perhaps also to their action increasing the permeability of the endothelial cells of the pulmonary circulation.
Clinical manifestations and symptoms of pheochromocytoma.
A peculiarity of pheochromocytomas is linked to the fact that, at least in half of the cases, the secretion of the vasoactive amines does not occur with a constant flow, but there is a storage of the substances inside the tumor cells, with the disposal of large quantities in certain circumstances. The stimulus to the release of catecholamines, which obviously corresponds to a symptomatology with a typically paroxysmal trend, is generally constituted by an increase in intra-abdominal pressure: the bending of the bust, sneezing, rice crises, a large meal, defecation efforts or the same urination (this is the case of the very rare bladder pheochromocytomas; however the effort of urination can cause the withdrawal of catecholamines even from sites other than the bladder) can trigger the hypertensive crisis.
Sometimes a simple urography or even a deep palpation of the abdomen may be sufficient. In some cases, however, crises can appear without a clear trigger; they can be rare, with episodes several months apart, or frequent, several times a day. The duration varies from a few minutes to a few hours, but in general these are never particularly long periods; there is often a tendency to increase in frequency with the passage of time.
The pressure trend can take different forms. In about 25% of cases the pressure usually remains at normal levels, and hypertensive episodes are inserted on these at more or less close intervals. In about 30% of patients with pheochromocytoma, blood pressure values are persistently elevated and paroxysmal hypertensive episodes are added to this underlying hypertension. Finally, in another 30% of patients, stable hypertension is found, without paroxysmal seizures. Another 15% has a completely irregular blood pressure trend. It is therefore important to note that, if in a certain number of cases patients appear to be normotensive outside the critical periods (and it is therefore right to consider the hypothesis of pheochromocytoma in the face of paroxysmal hypertensive episodes), most patients present constantly high blood pressure levels and some of them never have hypertensive crises. From the clinical point of view, the patient can be completely asymptomatic, although this occurrence is rare, and mainly related to forms secreting only continuous flow norepinephrine.
In general, however, pheochromocytoma involves a form of hypertension more commonly linked to symptoms, and the cardinal ones are made up of headache, profuse sweating, heartbeat; to these can be added, particularly in the forms secreting adrenaline, feelings of anguish and tremors. Angina-like symptoms may occur in older patients. During the visit, in addition to the detection of often significantly elevated blood pressure values, one can observe the presence of thinness, sweating, state of extreme anxiety, with dilated pupils, tremors. It is also important to look for signs of polyendocrinopathies and any abnormalities such as neurofibromas in these patients. More rarely, the patient presents with the symptoms and signs of dilated or hypertrophic cardiomyopathy (Chap. 8) and the picture may constitute a medical emergency, for acute episodes of hypotension, accompanied by extreme tachycardia and pulmonary edema. The causes of these cardiocirculatory phenomena have been illustrated in terms of physiopathology.
Pheochromocytoma Diagnosis
The presence of paroxysmal blood pressure is an element in favor of the diagnosis of pheochromocytoma, but does not give certainty. For this purpose it is necessary to carry out laboratory and instrumental investigations. Up to a few years
Triggering and / or suppression tests were used, the principle of which consists in administering substances capable of triggering or blocking hypertensive crises. Among the first are histamine, which causes a sudden release of catecholamines, tyramine or glucagon. These tests have now completely fallen into disuse as they are not without danger for the patient.
An inhibition of the action of vasoactive amines can be obtained by administering drugs capable of blocking sympathetic receptors: in patients with pheochromocytoma a drug of this type should lead to a reduction in blood pressure. For this purpose, phentolamine is usually used, a blocker: the test is considered positive if after administration a reduction in the values of the systolic pressure of 35 mmHg and of the diastolic pressure of 25 mmHg is obtained. However, it must be considered that this test can give up to a 25% of false positives and that it is suitable for the evaluation of patients with underlying hypertension only.
The safest method is to measure catecholamines and their metabolites in the blood and urine (Fig. 1.3). In the urine, adrenaline and noradrenaline, metanephrine and normetanephrine and vanilmandelic acid can be measured. Most of the catecholamines are excreted in the metabolized urine: adrenaline and norepinephrine are found in quantities of the order of micrograms, while vanilmandelic acid is in the order of milligrams, therefore its dosage is much easier. The evaluation of amino derivatives after a hypertensive crisis is particularly useful; therefore it is advisable to start urine collection for 24 h immediately after a paroxysmal episode. The only drawback related to this test is that many substances are able to modify the urinary levels of vanilmandelic acid, and among these first of all many foods containing vanillin, such as sweets, tea, coffee, various fruits (citrus fruits, bananas) in addition to countless drugs. Some particularly equipped laboratories are able to perform the dosage of adrenaline and noradrenaline in the plasma.
Once an increase in the levels of catecholamines has been ascertained, the problem of the localization of the pheochromocytoma arises: this is quite simple if the neoformation is found in the adrenal gland, which happens approximately in 90% of cases; ultrasonography is a bloodless instrumental examination, however capable of highlighting neoformations of moderate size. An analogous argument can be made with regard to computerized axial tomography. Arteriography allows the visualization of circulatory abnormalities of the affected adrenal gland; a venous catheterization, in expert hands, allows selective dosages of catecholamines in different regions, useful above all in the suspicion of extra adrenal pheochromocytomas.
These maneuvers are not entirely risk-free, as they can themselves trigger a hypertensive crisis. Therefore, a pharmacological blockade of the alpha-adrenergic receptors is usually practiced concomitantly.
Prognosis and therapy of pheochromocytoma
The disease is amenable to radical surgical treatment with a 5-year median survival of more than 95% for benign forms. In about 75% of these patients, the intervention involves a restoration of blood pressure values to normal. Alternatively, the disease leads to all the consequences of arterial hypertension on the target organs; in addition there is the risk of extremely dangerous and sometimes fatal hypertensive episodes.
In 95% of cases it is a benign heteroformation, however the diagnosis of malignancy cannot be established except a posteriori, in relation to the tendency or not to metastasize. The malignant forms are more common in extra-adrenal neoplasms and affect the loco-regional lymph nodes, therefore the skeleton, liver, lungs, central nervous system. The prognosis of malignant forms is variable and, if in the past it was described as particularly poor, cases with longer survival have recently been reported.
Tags: Catecholamines Endocrinology Hypertension
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David Zhang joined the Trillium Network for Advanced Manufacturing in July 2017 as Program Officer. David is a 2016 HBA graduate from the Ivey Business School at Western University. He was a Western National Scholar and an Ivey HBA Leaders Scholarship recipient. David's interests span the private, public, and non-profit sectors. He spent two summers working as a private equity analyst in Beijing, worked a year as a Research Associate at the Lawrence National Centre for Policy and Management, and currently sits on the City of Waterloo's Economic Development Advisory Committee. In his spare time, David enjoys playing the piano, reading, cycling, running, travelling, and volunteering.


 Our main business scope is Auto parts, Trailer parts, Construction machinery parts, Oil and gas pipeline fittings etc.
Rizhao Dexin Machinery Manufacturing Co.,ltd was originally established in 2012.Our company is an trade-orientd machinery manufacturing enterprise which dealing with tooling making, precise forging, heat-treatment, machining and finished product packaging.
Our company covers an area of 22000 square meters, and the construction covers an area of 12000 square meters. Currently we have more than 130 employees, more than 20 engineers involved in technical and quality control.
We have 4 forging lines currently, including 1000T+630T friction press production line, the 2500T hot die-forging press line, the 1000T electric screw press line,the 400T+300T press production line. The proposed yearly capacity is 20000 tons. More than 30 CNC and CN lathes, including a trailer spindles production line. We have kind of heat treatment equipment, including continuous heat treatment production line, pit furnace, high frequency quenching furnace.
Quality control:Passed IATF16949 quality certification, company have performance testing equipment such as spectrum analyzer, CMM, metallographic and mechanical.
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The main markets area in USA, Japan and European etc.


Increasing user engagement is critical for delivering customer experience in numerous industries. In our increasingly connected world, being able to monetize that data is a game changer for the communications industry. Dashbot is a bot analytics platform that offers metrics like engagement, retention, demographics and sentiment. It enables marketing managers and customer support teams to guage user experience or campaign performance in real-time.
We recently spoke to their founder Arte Merritt ahead of his panel session at Mobile World Congress.
Dashbot offer bot analytics with additional tools to take action on the data. In addition to traditional metrics like retention and engagement, we provide bot specific ones like sentiment analysis, conversational analytics, AI response effectiveness, and even the full transcripts. We also have tools to take action on the data like our Live Person Takeover of chat sessions and Push Notifications for reengagement.
We support Facebook, Alexa, Google Home, Slack, and Kik natively, and have a generic API for any conversational interface. We launched about 10 months ago, have over 2,200 bots on the platform and have processed nearly 900 million messages.
The three co-founders are serial entrepreneurs – myself, an MIT alum, I founded the mobile analytics platform Motally, which I sold to Nokia. Jesse Hull, an MIT alum, co-founded Mesmo.TV which he sold to the Game Show Network. Dennis Yang, a Cornell alum, co-founded Bureau of Trade which he sold to eBay. We're funded by ffVC, Bessemer Ventures, Samsung, Scrum Ventures, BDMI, and Rembrandt Venture Partners.
What kind of insights can bot analytics offer?
The tracking mechanisms are different. Anything that is click stream or event based tracking loses the richness of the messaging.
The content is different. Users are sending unstructured data to bots – images, audio, video, location maps, and more importantly, their own voice, their own words saying what they want from the bot, and what they think of the bot, which sometimes may not be pleasant.
The processing is different. Conversational interfaces can be multi-user and asynchronous – this is quite a bit different from web and mobile. It opens the door to different types of users and sessions depending on how active or passive they are.
There are new types of reports. With conversational interfaces, now you have new types of reports like sentiment analysis, AI response effectiveness, conversational analytics, the message flows through the bot, transcripts, and more.
Given the data is much richer, there's an opportunity to take action on the data in real time to improve the user experience and retain users. For example, with our Live Person Takeover, if a user is having difficulty with the bot, you can pause the bot, insert a live person, and help lead them through to conversion.
How can brands get (and offer) more value from this kind of platform?
Our platform helps brands increase user engagement, retention, and monetization. With our reports, product managers can learn more about their users and see how users interact with their bots including the common messages, user flows, demographics, and more. Marketing managers can use our CRM tools to re-engage users and bring them back to the bot. Customer support can use our Live Person Takeover to help users have a better experience and lead them to conversion.
Given users send in unstructured data, it's important to look at the messages and see if your bot is responding properly. We have reports for Top Messages in and out from the bot, as well as our Message Funnel which allows customers to see the flows through their bots. With this information, they can see where the bot is breaking down or not responding appropriately and improve the responses. They can also see the types of messages users are sending in which could lead to new features and functionality.
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What does it mean for customer acquisition and CX?
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In regards to retention, our Push Notification feature enables customers to segment their audience and send broadcast messages to re-engage their users – all based on the data. Through our Top Messages in and out, Message Funnel, and full transcripts, developers can better understand how their users are using their bots and improve the overall user experience.
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Are we at the tipping point for Natual Language Processing?


text:
Izvorul din satul Fîntînița este un monument al naturii de tip hidrologic în raionul Drochia, Republica Moldova. Este amplasat în partea de sud-est a satului Fîntînița. Ocupă o suprafață de 2 ha. Obiectul este administrat de Primăria comunei Fîntînița.

Descriere
Izvorul se află în lunca unui mic afluent al Răutului. În 2006, din surse locale și extrabugetare, aici a fost amenajată o fântână de acumulare a apei izvorâte din adâncime (numită și "ghiol"), care are pereți din piatră și acoperiș din lemn și olane roșii, utilată și cu o țeavă de scurgere a apei. Aria protejată este parțial îngrădită, cu poartă decorativă și cărări de acces construite din lemn. Are parte de o vegetație bogată: sălcii, conifere, stufării etc.

Izvorul are apă rece, este oligomineral după gradul de mineralizare și descendent de vale (apărut în luncă) din punct de vedere geologic. După compoziția chimică, este un izvor cu apă hidrocarbonat-sulfatată–sodiu-calciu-magnezică (HCO3 – SO4; Na – Ca – Mg). Apa este potabilă. Nivelul de poluare cu nitrați este neglijabil: 10 mg/l, adică 20% din concentrația maxim admisă. Indicele pH al apei are valoarea de 7,4. Mineralizarea depășește concentrația maxim admisă cu 10-60%, apa având 1.120-1.610 mg/l.

Statut de protecție
Izvorul este un obiect hidrologic de valoare națională, cu debit mare, de 30 l/min. Contribuie la debitul râului Răut și asigură funcționarea ecosistemului de luncă. Apa este utilizată în consumul alimentar și în scopuri tehnico-agricole. Potențialul turistic este mare datorită bunei amenajări a teritoriului, dar și istoricului acestui izvor. El a fost construit în perioada de dominație a Imperiului Otoman, prin procedee specifice turcilor: utilizarea așa-numitelor "ghizdele" (de aici și toponimul Ghizdita) etc. Astfel, obiectivul este de interes pentru turiștii din zonă și din țară.

Din 1998, izvorul beneficiază de statutul de monument al naturii, conform Legii nr. 1538 privind fondul ariior naturale protejate de stat. În anexele legii, se atestă că acesta aparținea Întreprinderii Agricole "Victoria". Între timp, el a trecut la balanța Primăriei comunei Fîntînița, a cărei reședință este satul Fîntînița.

Impactul antropic este redus, iar starea ecologică a ariei protejate este bună.

Note

Bibliografie

Fîntînița, Izvorul din satul
Fîntînița
Raionul Drochia

redpajama_set_name: RedPajamaWikipedia


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text:
The Decemberists' 'Hamilton' Song About Ben Franklin Is Here & Fans Can't Seem To Get Enough — LISTEN
By Nina Bradley
Kevin Winter/Getty Images Entertainment/Getty Images; babjex/Twitter
In awesome news, on Friday, Dec. 15, Lin-Manuel Miranda dropped a new Hamilton song, and fans already can't seem to get enough of the catchy tune. The single, which is titled "Ben Franklin's Song," features a roll-out of Miranda's most recent lyrical offerings set to music from indie-rock band, The Decemberists. The catchy new song has been revealed to be part of a larger project coming from the playwright, which he notably dubbed The Hamildrops.
A press release, which was shared with Variety, describes Hamildrops as long-running mixtape that will offer fans "new Hamilton content" every month for the next year. The news comes as a perfect holiday surprise for fans of the musical, who will seemingly get 12 new songs to rock out to in 2018. Miranda dropped the first track off his latest project early on Dec. 15. The melodic, expletive-laced tune was met with great pleasure by followers of the talented lyricist.
The song kicks off with the singer inferring that the world should be thankful for Ben Franklin's inventive contribution to the discovery of electricity. Entertaining from beginning to end the, perhaps, most striking moment of the single enters when, lyrical delivery offers listeners the bravado reminder that he's "Benjamin F*cking Franklin." Yep, that seriously happens — and it's amazing. The fades out with further emphasis:
"(Do you know who the f*ck I am?) Who the f*ck I am?
(Do you know who the f*ck I am?) Who the f*ck I am?
(Do you know who the f*ck I am?)
I am Poor-Richard's-Almanack-writing
Polymath, bifocal-wearing
Hardened glass-harmonica-playing
Benjamin F*ckin' Franklin"
The melody is entrancing, while the lyrical content is certainly something that'll easily keep your interest with just one listen.
Atlantic Records on YouTube
Wildly entertained by Miranda's latest offering, fans jumped to Twitter to share their thoughts on the tune.
1. Real Tears
News of the new project sent one fan through a repetition of crying fits.
2. Playlist Complete
This fan can't wait for more, promising to keep the song on repeat until the next installment arrives in January.
3. We Are Not Worthy
One commenter doesn't feel deserving of monthly gifts headed their way.
4. Makes You Wanna Dance
Another fan used a meme to express how excited they were over the Hamildrop release.
5. Saving Grace
Meanwhile, this enthusiast has named Miranda the real MVP of 2018.
6. Naughty & Nice
Another social media user is totally here for "Ben Franklin's Song"'s explicit lyrics.
7. Work Of Art
Using the song's notable expletive, this fan points out the single's perfection.
8. Aye!
This fan can't contain their enthusiasm, sharing a GIF of Miranda showing off some major dance moves.
9. How Much Is Too Much?
Another person has a serious question about listening to the song on repeat.
10. Franklin Fri-Yay
The song is helping to usher this listener straight into vacay mode.
While it remains unclear just how many other artists Miranda will collaborate with on the new Hamildrops project, details of his recent press release shared by Variety offer more insight on the background of his latest musical foray. He explained,
"A year ago this month we released The Hamilton Mixtape. It was the culmination of so many dreams come true. Every artist, every interpretation represented the original impulse I had for this story, even before this thing was a musical."
Revealing that the new release is in lieu of the promise he made to drop Hamilton Mixtape Vol. 2, he went on to reveal that his new Hamildrops is something totally different. Miranda continued,
"I know I promised you a Hamilton Mixtape Vol. 2, but nothing's gonna match those songs in that order, beautifully sequenced by @J.period, at that moment in December 2016 ... ALL THAT BEING SAID… I STILL HAVE ALL THIS DOPE NEW SH*T TO SHARE WITH YOU."
As Benjamin Franklin's Song continues to stream its way into the hearts of listeners everywhere, it's safe to say that fans of Hamilton and Lin-Manuel Miranda are having the best Christmas season ever.


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This textbook offers a unique introduction to classical Galois theory through many concrete examples and exercises of varying difficulty (including computer-assisted exercises).
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A valuable reference and a rich source of exercises with sample solutions, this book will be useful to both students and lecturers. Its original concept makes it particularly suitable for self-study.


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The Storm Is Coming. The first easy classic rock guitar song, Riders On The Storm, is a musical tour de force and shows the Doors at the height of their creative musical powers. The structure of the song is simple and brings you back to the genesis of most great American music: the blues.
Learn Classic Rock Songs on Ukulele with Rock Class 101. Tabs, Chords, Fingerstyle, Lesson Videos, and More! Van Halen, Led Zeppelin, The Beatles, and more!
6/10/2017 · The First Songs You Should Learn on Guitar Beginner Guitar Songs to Play With Easy Chords . Share Flipboard Email ... Learn These 8 Alt Rock Songs on Guitar Now. Learn the Basics of Guitar Strumming with This Easy Guide. Tabs for Easy Electric Guitar Riffs for Even the Newest Players.
6/26/2014 · 10 Famous Songs with Three Chords or Less. By Kathy Dickson. ... The following is a list of songs that are not only easy to learn, but also popular enough to get others singing along with you. ... Norman Greenbaum wrote one of the most recognizable guitar riffs in rock and roll history.
Classic 60s rock guitar lessons. Learn chords, rhythm patterns, solos, and more. Bootleg Guitar Lesson. Guitar lesson for the song "Bootleg" by Creedence Clearwater Revival. This tutorial covers the chords, rhythm, and lead fills. Chord diagrams and tabs are provided for lead fills.
A thorough guitar lesson focusing on the simplicity and re-usability of the most common hard rock chord progressions and sequences.
12/11/2012 · Many readers come to my site looking for easy classical guitar sheet music and other materials so I've decided to offer a few items here. When I refer to beginners I am thinking of a player who has completed an introductory method books and figured out basic first position notes, simple rhythms, and key signatures. I'll include material from this site but also from other sites on the web.
The Classic Rock Book - Easy Guitar sheet music - Guitar sheet music by Various: Hal Leonard. Shop the World's Largest Sheet Music Selection today at Sheet Music Plus.
You can find all 'classic rock' ukulele songs on UkuTabs right here on this page, ordered by popularity.UkuTabs is your true source to find chords and tabs for all of your favorite songs. Ukulele players all over the world have direct access to UkuTabs its large and completely free song archive which is constantly being updated with new songs.


Both singer/pianist Lacrymosa and Brooklyn indie-pop outfit Bodies Be Rivers are new names to PressPLAY OK. The two parties have collaborated for a new EP, Light Falls, offering contributions to each others' work in the loveliest way. That comes good on Quiet Weather, a haunting and elegiac piano-driven track that finds moving beauty in its sparseness.
It's desperately moving stuff, and you can hear it below.
The vinyl 7″ (and digital EP which features two additional songs) will be released on August 26 via Gold Robot Records. You can preorder it now.


Clinton Hill Foodie: Buff Patty?
I've walked by Buff Patty on Myrtle a few times, most recently last night, when I decided to order from Kinara. Today I was curious, so I did a bit of Googling. Lo and behold, the place sounds really good.
I think I'm going to swing by tonight. Anyone have a recommendation on what to order? I know I want one of those empenada-like patties, but beyond that, I'm at a loss.
I really like their curried chicken. Yum!
i tried their jerk chicken, it was so good!
their patties are really good, beef patties are the best.
OH it's worth it for sure! The jerked chicken is the real deal and the patties are good as well.
I live right around the corner from Buff Patty & was psyched to try it when we moved in. Though the service was friendly and great, the food was mediocre. After reading these comments, though, I'm willing to give it another shot.


Welcome! Thank you for considering Sofen Family Dentistry for your dental needs. We are confident that you will be pleased with the qualities you will find in our office. Our staff is committed to your care and concerns. Dr. Sofen is committed to your understanding and education of the individualized treatment you need or desire.
We will help you become an active partner with us in achieving optimum dental health, so you may enjoy life more fully. After all, without your health, life can not truly be enjoyable. We believe people want to keep their teeth for a lifetime. By investing in your dental health and making preventive care part of your commitment, this goal can be realized.
We are able to do this by offering comprehensive education and by providing you with instructional literature if there is a dental health topic you'd like to know more about. All of our staff believes this is the best way to treat our friends. We hope our pleasing atmosphere encourages you to ask questions about any aspect of our office, or about your care and treatment. We hope you will be as excited about achieving optimum health as we are excited about helping you achieve it. In summary, the words that are key to our practice are "quality" and "prevention." We believe if quality service is provided to you, more extensive work in the future will be prevented.
In the dental profession, dramatic changes and new techniques develop continuously. Our commitment to you is to keep abreast of these improvements by meeting high education and experience standards.
Andrew P. Sofen, DDS is located at 17886 Farmington Rd, Livonia, MI. We are currently accepting new patients, and you can schedule an appointment by calling 734-436-0598.
Dr. Sofen and the staff at Andrew P. Sofen, DDS provide quality dental care to patients in the Livonia area, focusing on a comprehensive approach to oral health. By treating and educating patients, our team helps patients to stay healthy in between visits. Our staff understands the importance of listening to patients, helping them to feel comfortable and relaxed. This personal approach is evident in everything we do. From making an appointment, filling out paperwork, conducting an examination, and providing dental treatments, the staff at Andrew P. Sofen, DDS take the time to connect with patients and give them the thoughtful attention they deserve. Our team is trained on advanced dental procedures and techniques so that patients can benefit from the latest in dental care.
Andrew P. Sofen, DDS provides a wide variety of dental services and procedures to address all of our patients' dental health needs. By combining quality patient care with up-to-date technology, we are able to treat patients of all ages in a comfortable and relaxing setting. Our website includes information on the following items: Dentist, Cosmetic Dentist, Family Dentist, General Dentist, Emergency Dentist, Dental Implants, Teeth Whitening, Dental Veneers, Dentures, Dental Crowns and more. Our Dentist and expert staff are trained to not only treat patients but to identify what caused the health concern in the first place. This comprehensive approach sets patients of Andrew P. Sofen, DDS on the road to recovery and long term oral health.
When you walk into the office of Andrew P. Sofen, DDS you will be immediately greeted by our friendly staff who are dedicated to making sure that you feel comfortable during your entire appointment. We understand that patients can feel anxious when going to the dentist, and our staff will take the time to listen to all of your concerns and help you understand exactly what your procedure is going to be like. At Andrew P. Sofen, DDS we pride ourselves on being an affordable family dentist that accepts a variety of insurance plans and payment options like cash and credit cards, because we want to provide a beautiful, healthy smile to everyone in the Livonia area. Call Andrew P. Sofen, DDS today at 734-436-0598 to see why we are the dentist of choice in the Livonia area.
© 2019 Andrew P. Sofen, DDS. All Rights Reserved.


Emotions run high when qualifiers find out whether they made the race. By April, respect returns.
Lisa Miele, 45, of Lincroft, New Jersey, will run her second Boston Marathon on Monday to raise money for One Mission, an organization that helps children with cancer. While almost everyone she has encountered has been positive about her decision to run for charity in Boston, one former coworker took issue with it.
Miele said she was always very clear in her communication with others that she was a charity runner, and she was taken aback by the venomous message.
Such vitriol is rare, runners say. But as it gets more difficult each year to gain a spot in the Boston field as a qualifier, some runners who can't get into the race harbor resentment toward charity runners.
Interest in the race has grown so much that it's no longer enough to run a marathon in a qualifying time for your age and gender. Now the field fills on a rolling basis, and the fastest runners get in first. In order to earn a bib for the 2016 Boston Marathon based on qualifying time, runners needed to be faster than their qualifying times by at least 2:28. This left 4,562 runners who met their qualifying times on the sidelines.
The BAA also points out that most funds "directly benefit the community." Boston charity runners raised a collective $28.3 million in 2015.
Even that huge sum, however, isn't enough to offset the pangs some qualified runners feel in September when registration opens, and they find themselves shut out.
Adam Frager, 43, of Newport News, Virginia, ran 3:13:07 at the 2015 Newport News One City Marathon, 1:53 under his Boston Marathon qualifying time, but 35 seconds too slow to get into the 2016 race. Frager understands the value of having charity runners in the Boston Marathon, but he believes runners who have met their qualifying times should take precedence at registration time.
New Hampshire's Keith Somers, 42, who ran the Boston Marathon four times as a qualified runner, agrees.
"I think that the people that actually work for their qualifying times deserve preferential treatment," he told Runner's World by phone.
Frager and Somers said they have no problems with having charity runners in the Boston Marathon, but they would want to earn their spots in the race by running qualifying times.
"I'm competitive. I've always been a competitive athlete. [Qualifying for Boston] was something that I wanted to earn and not buy my way into," Somers said. Frager and Somers said that they don't blame charity runners for taking spots that are set aside for them in advance of registration.
Susan Hurley, owner and founder of Charity Teams, an organization that helps charity runners train and fundraise for the Boston Marathon and other races, says that over the years, she's seen improved attitudes regarding the inclusion of charity runners in the Boston Marathon.
In the end, he says, he learned a lot about the value of the charity program in Boston.
Hurley has seen some changes in the makeup of the charity running population in Boston in recent years. She's had an increasing number of applicants who met their qualifying times but were shut out of the race. And she's seeing more runners who already have their own bibs, either through qualifying or an invitational entry, but they voluntarily run for charity.
For the most part, if qualified runners are looking down on those who get into Boston without qualifying for the race, they tend to keep it to themselves.
Jeff Maher, 49, of Overland Park, Kansas, ran his first Boston Marathon in 2011 as a charity runner. He says that though he's overheard conversations in which people have expressed frustration that non-qualified runners are taking spots that should go to those who meet the qualifying times, he's always been treated well in Boston, whether he's qualified for the race or not.
Though Maher initially got into Boston through a charity bib in 2011, he then qualified for the race and voluntarily ran three more years for Jumpstart for Young Children.
Hurley hopes that the line between charity runners and qualified runners in Boston eventually blurs more.
"My goal would be to one day have something on the Boston Marathon [registration page] that says, 'As a registered runner, you can also run for charity, which charity would you like to run for?' I would love to see that," Hurley said.


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Home / News Stories / UNC Researcher Develops Test Scenarios for Sustaining Ecotourism in the Galápagos
UNC Researcher Develops Test Scenarios for Sustaining Ecotourism in the Galápagos
UNC researchers Scott Gifford and Adrian Marchetti take water samples off the Galapagos Islands in 2015. Photo by Mary Lide Parker.
If ecotourism in the Galápagos Islands—a province of Ecuador 1,000 kilometers from the mainland—continues to match its growth rate of the past two decades, the renowned sea turtles, giant tortoises, marine iguanas and unique landscapes that help attract visitors face serious risks.
That's among the scenarios developed by researchers at the University of North Carolina at Chapel Hill Center for Galápagos Studies and the joint UNC-Universidad San Francisco de Quito (USFQ) Galápagos Science Center as part of a new effort to help Ecuador government officials plan for the future as they aim to balance economic development and resource conservation in a World Heritage site.
A new paper describing the research team's models forecasting potential outcomes appears in the Oct. 10 issue of the Proceedings of the National Academy of Sciences.
More than 225,000 people visited the Galápagos in 2015, and the residential population has grown to about 30,000 as people flock to the island for higher wages in the booming ecotourism economy.
In an effort to sustainably develop and manage growth, the Ecuador government asked Steve Walsh of UNC and Carlos Mena of USFQ, co-directors of the Galápagos Science Center, to generate scenarios of change reflecting the number of tourists and residents that the islands could accommodate before they start to lose their luster.
The resulting models drew from several representations of Galápagos society, human-environment interactions and how people function within both human and natural systems. For example, Walsh and Mena pulled data from multiple demographic, tourist, economic and environmental sources for analysis through computer modeling to predict how much growth the islands can sustain by 2033.
"The Ecuadorian government and the Galápagos National Park are asking the exact right questions," said Walsh, the Lyle V. Jones Distinguished Professor of Geography at UNC-Chapel Hill. "No one wants a boom and bust situation. We want wise, managed growth within the concept of sustainability."
Although the focus of the research was on the Galápagos, Walsh said he wanted to refine the models to study human-environment interactions affected by social and ecological forces and factors originating in the islands and beyond their shores.
"Our modeling is an attempt to help guide wise stewardship of a special place, and I think the models give us the opportunity to create a computerized natural laboratory to test scenarios of change," he said. "As we build these models, the notion is to understand the Galápagos and to export them to similarly challenged places around the globe."
The goal of the study and the models is not to tell governments what to do, but to help them make more informed decisions about the sustainability of island ecosystems and future threats.
"We see our models as tools for decision-makers that can help them understand and evaluate the value of special places and the risks they're willing to tolerate," said Walsh. "Our models allow decision- makers to look at scenarios of change and to choose what best matches their management goals and their sense of value and risk."
Using models to simulate behavior and feedback between people and the environment always has some uncertainty, he said. Researchers used real data, computed actual functions that linked variables and social and ecological processes, and performed analyses to determine the degree of uncertainty in their findings.
"We're not simulating data. We're not making up data. We're not using theory to guide it," said Walsh. "It's real data and real functions, and that improves the performance of the models."
The Galápagos Science Center is a joint effort between UNC-Chapel Hill and the Universidad San Francisco de Quito. The two universities built a research facility in 2011 on San Cristóbal Island to promote science and education that will help protect the fragile island ecosystems and enhance the lives of their inhabitants. The facility is being used by UNC and USFQ faculty and students conducting research on the Galápagos Archipelago in association with the Galápagos National Park. UNC students use the facilities for study abroad experiences and to support their work on undergraduate, graduate and doctoral theses and dissertations.
The facility houses four laboratories focusing on terrestrial ecology, marine ecology, geospatial technologies, microbiology and genetics. With a permanent staff, field measurement equipment and several permitted projects that extend across the sciences, the Galápagos initatives focus on population, health and environment through a focus on understanding the complex interactions among the social, terrestrial and marine systems of the Galápagos islands.
Communications and Public Affairs contact: Will Rimer, 919.445.0945 rimerwp@unc.edu


With both clubs fighting to avoid a drop down to the Championship, the experienced Michael Bradley has the steel to keep either Cardiff or Fulham up.
At 16th and 18th respectively in the Premier League table after yesterday's Boxing Day fixtures, Cardiff and Fulham are without doubt locked in a dogfight to avoid relegation.
Come the January transfer window, there aren't many players available who have the necessary grit and guile to help steer a club away from the relegation zone.
However, the experienced American Michael Bradley, of Roma in Italy, is just the sort of determined midfielder that both Cardiff and Fulham could so desperately do with and according to Caught Offside, both clubs are considering a January swoop.
With 82 caps and 11 international goals to his name, as well as spells in Holland and Germany and a brief loan spell at Aston Villa, this video illustrates Bradley's creativity from deep and impressive all round abilities.
Cardiff Fans: Seen Vincent Tan - Man With The Plan?


A woman had a long day at work and just wants to chill, but she can't stop thinking about how much she needs a degree. She begins rapping about finding a school for free using Education Connection. Soon enough, her and her friends are singing and dancing in their graduation cap and gowns.


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Nina Rodin>2020> Stuffed
date > January 2020
medium > giclée print on dibond (behind plexiglass)
size > 50 x 33cm
status > available through Karl Oskar Gallery
> This photo is part of the series of Self-Portraits with failed projects, both photographs and paintings. 'Stuffed' is both the title of the original work (link here) and of this portrait. The original work still lives in my studio and is one of my own favourites. But most people who see it want it to be lit up from inside, as if it were a lamp.
> But the gesture of putting this glass globe over my head is much more than about posing with a failed project. It is about my situation as a painter. In that sense, the word 'stuffed' also refers to my position as a female artist, as a scientist turned artist and to my position with the weight of painting's history. In many contemporary London Art schools, the painting department is seen as a bit stuffy.
> Installation shot of the print in the solo show at Karl Oskar Gallery:
> Related works:


How to build: Easy-to-build without the use of screws or glue. Simply place the bar between the two frames, make sure the holes are facing down. Use the two wedges to hold the gym together. Give the wedges a knock to make sure the gym is fastened.
Materials: Untreated Birch plywood veneer. from FSC certified suppliers in the EU. No toxic paints or varnish is used. Wedges treated with organic beeswax and walnut oil.
Includes 5 Toys - Baby cloud blue, Baby whisper blue, baby dot blue, teething string , Panda teether.
This Gym should never be left unattended with Babies / Children. Adult supervision is always required.


Coconut Oil: Can Oil Pulling Give You a Healthier Smile?
Your mouth is home to billions of bacteria, viruses, fungi and other parasites, and their toxins. Left unchecked, the build-up of biofilm (a thin layer of plaque) on teeth is a leading cause of tooth decay, gingivitis (gum disease), and bad breath. The simple action of oil pulling dissolves bacteria and sweeps it away as you expel it.
Coconut oil is unique because it's made almost exclusively of medium-chain triglycerides (MCTs). MCTs are metabolized differently than the long-chain fatty acids.
The medium-chain fatty acid, lauric acid makes up almost 50% of coconut oil. Your body breaks down lauric acid into a compound called monolaurin. Both lauric acid and monolaurin can kill harmful bacteria, fungi, and viruses in the body. (1) What's more, coconut oil is particularly effective at killing the oral bacteria streptococcus mutans, a leading cause of tooth decay.
Before you throw out your toothpaste and mouthwash, consider a 2017 review (2) of 21 studies on oil pulling for dental hygiene, which found only a handful to be stringently designed. The American Dental Association states that there is insufficient research to support the practice of oil pulling.
"The good news is there are very few reports of side effects for oil pulling in the literature or anecdotally," says Dr. Matthew Parr, DDS, owner of Surf City Dental. "I encourage my patients to be active participants in their oral health care. I wouldn't recommend oil pulling instead of brushing—like in some cultures—but rather as an adjunct," he concludes.
Use pure, unrefined coconut oil because it doesn't have any other additives and it hasn't been processed.
Begin with five minutes and work up to 20.
Discontinue if you experience any unpleasant side-effects.
(2) Mythri H. Oil pulling: A traditional method on the edge of evidence. Dent Hypotheses 2017; 8: 57–60.


text:
void read(const Utility::IniDoc::Doc&, const std::string&, Line&);
void read(const Utility::IniDoc::Doc&, const std::string&, Route&);
void read(const Utility::IniDoc::Doc&, const std::string&, const Stops&, DifTimeLines&dtlines);
void read(const Utility::IniDoc::Doc&, const std::string&, const Stops&, const DifTimeLines&, Schedule&);
void read(const Utility::IniDoc::Doc& cfg, WalkingTimes& wt);

inline std::string strip(std::string str) {
    char    c = ' ';
    auto    p0 = str.find_first_not_of(c);
    auto    p1 = str.find_last_not_of(c);
    if (p1 != str.npos) {
        str.erase(p1 + 1);
    }
    str.erase(0, p0);
    return str;
}

void read(const Utility::IniDoc::Doc &cfg, Lines& lines, StopDescriptions& sds) {
    const auto& ssection = cfg.at("stops");
    for (const auto& sline: ssection) {
        const auto& sdlist = sline.second.items();
        sds.emplace(
            std::piecewise_construct,
            std::forward_as_tuple(sline.first),
            std::forward_as_tuple(sdlist.cbegin(), sdlist.cend()));
    }

    const auto& lineslist = cfg.at("").at("lines").items();
    for (const auto& lstr: lineslist) {
//        std::cout << "Line: " << lstr << std::endl;

        auto&   line = lines.addLine(lstr);
        try {
            read(cfg, lstr, line);
        } catch (const std::out_of_range&) {
            std::cerr << "Error in line: " << lstr << std::endl;
            lines.removeLine(lstr);
        }
    }

    read(cfg, lines.walkingTimes());
}

void read(const Utility::IniDoc::Doc& cfg, const std::string& sname, Line& line) {
    const auto& routelist = cfg.at(sname).at("routes").items();
    for (const auto& rstr: routelist) {
//        std::cout << "    Route: " << rstr << std::endl;

        auto&   route = line.addRoute(rstr);
        try {
            read(cfg, sname + "." + rstr, route);
        } catch (const std::out_of_range&) {
            std::cerr << "Error in route: " << rstr << " (" << sname << ")" << std::endl;
            line.removeRoute(rstr);
        }
    }
}

void read(const Utility::IniDoc::Doc& cfg, const std::string& sname, Route& route) {
    route.setDescription(cfg.at(sname).at("description").string());

//    std::cout << "        Stops: " << cfg.at(sname).at("stops").string() << std::endl;
    const auto& stoplist = cfg.at(sname).at("stops").items();
    for (const auto& sstr: stoplist) {
        route.addStop(strip(sstr));
    }

//    std::cout << "        Platforms: " << std::endl;
    const auto& psection = cfg.at(sname + ".platforms");
    for (const auto& pprop: psection) {
        const auto& pstr = pprop.second.string();
//        std::cout << "            " << pprop.first << " -> " << pstr << std::endl;

        route.addPlatform(pprop.first, pstr);
    }

    DifTimeLines    dtimeLines;
    read(cfg, sname + ".durations", route.stops(), dtimeLines);

    Day day{};
    const auto& timetables = cfg.at(sname).at("timetables").items();
    for (auto day: week) {
        auto&   schedule = route.schedule(day);
        schedule.setStopCount(stoplist.size());
        if (day >= timetables.size()) {
            std::cerr << "Missing day " << day << " (" << sname << ")" << std::endl;
            continue;
        }
        const auto& ttstr = timetables[day];
        if (ttstr.empty()) {
            continue;
        }
        try {
            read(cfg, sname + "." + ttstr, route.stops(), dtimeLines, route.schedule(day));
        } catch (const std::out_of_range&) {
            std::cerr << "Error in day: " << day << "(" << sname << ")" << std::endl;
        }
    }
}

//  read [<line>.<route>.durations]
void read(
    const Utility::IniDoc::Doc& cfg, const std::string& sname, const Stops& stops, DifTimeLines& dtlines) {
//    std::cout << "        Time lines:" << std::endl;
    if (!cfg.count(sname)) {
        return;
    }
    const auto& section = cfg.at(sname);
    for (const auto& tlprop: section) {
//        std::cout << "            " << tlprop.first << " -> " << tlprop.second.string() << std::endl;

        auto&       dtline = dtlines[tlprop.first];
        const auto& dtlist = tlprop.second.items();
        auto        dtit = dtlist.cbegin();
        auto        stopIt = std::find(stops.cbegin(), stops.cend(), *dtit);
        if (stopIt != stops.cend()) {
            dtline.from = *dtit++;
        } else {
            dtline.from = stops.front();
        }
        std::for_each(dtit, dtlist.cend(), [&dtline](const std::string& dtstr) {
            dtline.durations.push_back(toDifTime(dtstr));
        });
    }
}

//  read [<line>.<route>.<timetable>]
void read(
    const Utility::IniDoc::Doc& cfg,
    const std::string&          sname,
    const Stops&                stops,
    const DifTimeLines&         dtlines,
    Schedule&                   schedule) {

    if (!cfg.count(sname)) {
        return ;
    }

    const auto& section = cfg.at(sname);
    for (const auto& tgprop: section) {
        auto        startTime = toTime(tgprop.first);
        const auto& tgdesc = tgprop.second.items();
        //  todo: manejar excepciones
        const auto& durId = tgdesc.at(0);
        auto        rep = tgdesc.size() > 1 ? tgdesc.at(1).asDecimal<size_t>() : 1;
        auto        cadency = toDifTime(tgdesc.size() > 2 ? tgdesc.at(2).asDecimal<size_t>() : 0);
        const auto& dtline = dtlines.at(durId);
        auto        fromIx = std::find(stops.cbegin(), stops.cend(), dtline.from) - stops.cbegin();
        while (rep--) {
            auto    tline = applyDurations(dtline, startTime);
            schedule.addTimeLine(fromIx, tline);
            startTime += cadency;
        }
    }
}

void read(const Utility::IniDoc::Doc& cfg, WalkingTimes& wt) {
    const auto wsectionIt = cfg.find("walking");
    if (wsectionIt == cfg.cend()) {
        return ;
    }
    for (const auto& wline: wsectionIt->second) {
        auto    ws = Utility::Literal{wline.first}.asList();
        if (ws.size() != 2) {
            throw std::runtime_error("invalid walking entry");
        }
        wt.emplace(
            std::piecewise_construct,
            std::forward_as_tuple(ws[0], ws[1]),
            std::forward_as_tuple(toDifTime(wline.second.string())));
    }
}


White flowers in spring followed by orange berries that persist into winter. Semi-evergreen.
This highly adaptable and low-maintenance shrub has attractive foliage and black autumn fruit.
Graceful multistemmed tree with spreading, slender branches. Outstanding fiery red fall colour.


Exceptional representatives at Toyota dealers near you are here to ensure your car purchasing experience or Toyota car service as simple as possible.
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