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Johnny Depp & Tim Burton's Dark Shadows Trailer Is Garishly Familiar & Uninviting
Do you remember when the Tim Burton name meant something more than just a commercial brand entity?
Do you remember when the Tim Burton name meant something more than just a commercial brand entity? Do you remember the time, long ago as it may seem now, when Burton's name being attached to a movie brought with it a sense of real anticipation that you were in the hands of a macabre genius who had big ideas, big imagination and the talent and vision to back up the uniquely weird & wonderful stories he wanted to tell? And back then when he had a leading man in a still hungry Johnny Depp who still cared about his filmography? Those days ended a long, long, long time ago. Depp and Burton firmly checked into the comfort zone of their careers just after the turn of the millennium, when studios would offer multi-million deals to get 'The Tim Burton/Johnny Depp package' and boy have they duly delivered for the execs in the past ten years. Warner Bros decided to leave it very late to emerge the Dark Shadows trailer out of the darkness and into the light of day less than two months before release. It was spotlighted on "Ellen" of all places yesterday and now the full-length trailer is online for the world to see. You can watch it below; http://www.youtube.com/watch?v=4cVcpz8H3Pk&feature=player_embedded The trailer hints at a clear bastardisation of the soap opera of yesteryear (so much so that you wonder why it wasn't instead conceived as an original piece) and is a 'fish out of water' 70's period piece (seriously... how obvious are the gags and music selection? Is anyone even trying here?), which has Burton's Johnny Depp playing Burton's wacko Johnny Depp (a cousin to Charlie & The Chocolate Factory and The Mad Hatter, et all) in a post-Twilight world where scarily this could end up passing $500 million worldwide and maybe even beyond. Who knows? This is a very, very broad Tim Burton comedy and one that will please a large crowd. But if audiences actually sat back and watched what was being served to them they would be able to tell that this is garishly familiar of the other Burton branding of other properties in the past decade and there's very little here of the early genius Depp/Burton delivered in 'Edward Scissorhands'. 1990 was twenty two years ago now and boy does it show. Set for release May 11th, Dark Shadows centers on Barnabas Collins, a playboy who breaks the heart of a witch (Eva Green) in 1752, and in proof that you should never scorn a woman, she turns him into a vampire and buries him alive. He wakes in 1972 and returns to his estate tortured and searching for his long lost love. He is owner of a large estate€ but our lead character and entry vehicle into this weird world is Bella Heathcote as Victoria Winters, the young lady who becomes the Governess of the Collins household because she resemblances the vampire€™s long lost love. Michelle Pfeiffer (the matriarch of the estate in Collins€™ absence), Jackie Earle Haley (as a con artist), Chloe Moretz, Thomas McDonnell, Johnny Lee Miller, Helena Bonham Carter and David Selby also feature. Seth Grahame-Smith wrote the final draft of the screenplay, the same guy who is currently working on a Beetlejuice sequel that Burton will likely direct with Michael Keaton and Johnny Depp after this. So more of the same to look forward to, basically.
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Posted On: 16th Mar 2012
Matt Holmes
Matt Holmes is the co-founder of What Culture, formerly known as Obsessed With Film. He has been blogging about pop culture and entertainment since 2006 and has written over 10,000 articles.
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Q: Representing disease and syptom in pomegranate bayes network I'm trying to work out P(m|s) probability of meningitis given "stiff neck"
So I'm trying to represent this in the model:
P(m|s) = (P(s|m) * P(m))/P(s)
P(s) = 0.1
P(m) = 0.0001
P(s|m) = 0.8
this is how I've represented it:
meningitis = DiscreteDistribution({"have meningitis": 0.0001, "no meningitis": 0.9999})

stiffNeckIfMeningitis = ConditionalProbabilityTable(
        [["have meningitis", "stiff", 0.8],
         ["have meningitis", "not stiff", 0.2]
        ],[meningitis])

I have to specify the values for ["no meningitis", "stiff", x] and ["no meningitis", "not stiff", x] which I did by manually working out the values, but should the bayes network not be doing this?
Should I have have a Discrete distribution like this too:
neck = DiscreteDistribution({ "stiff": 0.1, "not_sitff": 0.9})

I'm completely stumped on how to represent the relationships in the model = BayesNetwork() bit.
At the moment I have:
s1 = Node(meningitis, name="meningitis")
s2 = Node(stiffNeckIfMeningits, name="stiffNeckIfMeningits")
model.add_states(meningitis, stiffNeckIfMeningits)
model.add_edges(s1, s2)
model.bake()

redpajama_set_name: RedPajamaStackExchange


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PRIME Talks Expo
DISTINCTION Secret Supper
DISTINCTION Bar School
Top 40 Under 40 Reunion
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Scholastic Achievement
The Virginian-Pilot Scholastic Achievement Scholarship and Recognition Program recognizes outstanding academic achievement.
By providing recognition and financial resources to students with exceptional academic achievements,
service and leadership, we are making an investment in the future of our community.
Each participating high school selected a team of up to 24 students, depending on school size, who excel in academics, citizenship, school activities and community service.
Each school had the opportunity to choose a senior to compete for one of The Pilot's two scholarships: $5,000 each.
Student achievements, career goals and college choices were reported through early March.
The judges' criteria included transcripts, test scores, curricula, leadership, service within the school and community, and financial circumstances.
Finalists were interviewed by a panel of judges. The scholarships are awarded directly to the colleges of the students' choice.
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2020 Student Honorees
Click your corresponding school to find your students name!
Atlantic Shores Christian School
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is a senior chief petty officer with 14 years combined service in the U.S. Navy and Navy Reserves, currently assigned to Joint Expeditionary Base Little Creek-Fort Story. She previously worked as a media sales executive at The Virginian-Pilot and was awarded the 2018 Sales Rookie of the Year Award. Stangler earned a bachelor's degree in communication from Old Dominion University. She is a recruitment coordinator with the C.W. Bill Young / Department of Defense Marrow Donor Program and serves as a board member for the Chief Petty Officers Association Hampton Roads chapter.
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is the regional director of consumer marketing for The Virginian-Pilot. He started with Landmark Media Enterprises in January 2001 as home delivery manager and then served as distribution manager. Previously, Quan worked at the Los Angeles Times.
Pam Catindig
Pam Catindig is a founding partner at of Maverick Marketing Advertising & Public Relations, a Virginia-Beach-based firm focused on the needs of nonprofits, including Nauticus and the battleship Wisconsin, the Virginia and Roanoke symphony orchestras, Sandler Center Foundation, Access College Foundation, CIVIC Leadership Institute and many others. Prior to Maverick's launch, Catindig reported to the president and publisher of The Virginian-Pilot as the innovation champion, tasked with helping develop new revenue opportunities.
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is the senior vice president of OnCall Telecom, International, headquartered in Virginia Beach, VA. Salvage helps his enterprise clients around the globe implement and manage complex technology solutions, as well as overseeing the day to day company governance of OnCall. Salvage served on the national CenturyLink Advisory Council from 2014 to 2016, and was a 2016 Vonage Business Advisory Council member. He currently holds positions on the 2018 and 2019 Avant Advisory Council and the 2019 Intelisys SE Advisory Council. Salvage was featured in March 2018 on the Channel Outlaws podcast and is also a contributor to a published Polycom case study.
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Securing IT services and infrastructure by relying on the deployment of proprietary, purpose-built hardware simply cannot meet the demands of today's dynamic environments, according to a report published by SDxCentral.
The report, entitled "2016 Next-gen Infrastructure Security Report" noted that today's solutions must mirror the networks in which they need to be deployed. These solutions must be able to effectively secure all the highly virtualized, hybrid networks, new services and applications and managed, mobile, Internet of Things (IoT) devices that make up the software-defined everything (SDx) Infrastructure. The authors claim that almost every security function can be delivered in software.
The premise for this report by is to address the threats to and challenges of cybersecurity, which are evolving rapidly as a result of cloud delivered IT services and infrastructure.
As threat factors accelerate, so too do the countermeasures and today, there exists a variety of infrastructure solutions that are capable of neutralizing such threats.
Telco Systems' CyberGuard solution is profiled in the report. NFV CyberGuard is a virtualized cybersecurity solution for protecting SDN and NFV infrastructures, which consists of advanced networking probes, NFVI agents, and a big data analytics engine. It provides complete visibility of the entire network, real-time analysis of network threats and the ability to apply cybersecurity policies to the entire infrastructure.
The solution is designed specifically to protect SDN and NFV networks.
It is deployed as a NFV at the network edge at the closest point to all endpoints, providing real-time monitoring and analysis of network threats, complete visibility of the entire network and the ability to apply cybersecurity policies and efforts to the entire infrastructure.
In 2016, NFV CyberGuard received industry recognition in the form of two awards. First, it was recognized with the Global Excellence Award for Best Security Solution for Telecommunications at the Global Excellence Awards. Additionally, it was awarded the Cybersecurity Excellence Award 2016 recognizes the world's best cybersecurity products, individuals and organizations.


Flamingos are everywhere at the moment, so Gail Penberthy has designed these two fantastic three dimensional flamingo cushions that will brighten up any home, caravan or motorhome. They are great fun to make and you get the instructions to make both sizes of the flamingos. The large one measures 19 x 14 inches and the small one measures 15 x 11 inches.


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by Aliki & illustrated by Aliki ‧ RELEASE DATE: May 1, 2010
What little person does not love to push buttons, especially if all those pushed buttons yield fascinating and rewarding effects? Aliki's young Push-Button boy loves all sorts of buttons: phones, toasters, remotes, water hoses—you name it! In fact, this little guy pushes so many buttons that his pointer finger gets sore, and his bandaged digit has to find other things to do, like playing outside, painting, pounding and, eventually, reading. (In a sweet and apt homage, he's reading Ashley Bryan's 1995 picture-book rendition of "What a Wonderful World.") The bright white background helps the primary colors pop for the lap listeners while the rhyming couplets, with just a few lines per page, make the text easy to memorize. The words for the sounds—FLUP! CLACK! RINGGG! WHOOOSH!—are handwritten in happy colors that will keep younger readers interested in turning the page. Push-Button boy's life, with or without a bandage, is one where he is happy, busy and the center of the action. Completely in sync with toddlers. (Picture book. 2-5)
Publisher: Greenwillow Books
Review Posted Online: Dec. 28, 2010
More by Aliki
QUIET IN THE GARDEN
by Aliki and illustrated by Aliki
A PLAY'S THE THING
by Aliki & illustrated by Aliki
AH, MUSIC!
Little Blue's fans will enjoy the animal sounds and counting opportunities, but it's the sparkling lights on the truck's own...
by Alice Schertle ; illustrated by Jill McElmurry ‧ RELEASE DATE: Sept. 23, 2014
The sturdy Little Blue Truck is back for his third adventure, this time delivering Christmas trees to his band of animal pals.
The truck is decked out for the season with a Christmas wreath that suggests a nose between headlights acting as eyeballs. Little Blue loads up with trees at Toad's Trees, where five trees are marked with numbered tags. These five trees are counted and arithmetically manipulated in various ways throughout the rhyming story as they are dropped off one by one to Little Blue's friends. The final tree is reserved for the truck's own use at his garage home, where he is welcomed back by the tree salestoad in a neatly circular fashion. The last tree is already decorated, and Little Blue gets a surprise along with readers, as tiny lights embedded in the illustrations sparkle for a few seconds when the last page is turned. Though it's a gimmick, it's a pleasant surprise, and it fits with the retro atmosphere of the snowy country scenes. The short, rhyming text is accented with colored highlights, red for the animal sounds and bright green for the numerical words in the Christmas-tree countdown.
Little Blue's fans will enjoy the animal sounds and counting opportunities, but it's the sparkling lights on the truck's own tree that will put a twinkle in a toddler's eyes. (Picture book. 2-5)
Publisher: HMH Books
Kirkus Reviews Issue: Sept. 1, 2014
Categories: CHILDREN'S CONCEPTS | CHILDREN'S HOLIDAYS & CELEBRATIONS | CHILDREN'S TRANSPORTATION
More by Alice Schertle
TIME FOR SCHOOL, LITTLE BLUE TRUCK
by Alice Schertle ; illustrated by John Joseph
LITTLE BLUE TRUCK'S VALENTINE
GOOD NIGHT, LITTLE BLUE TRUCK
Plotless and pointless, the book clearly exists only because its celebrity author wrote it.
by Jimmy Fallon ; illustrated by Miguel Ordóñez ‧ RELEASE DATE: June 9, 2015
A succession of animal dads do their best to teach their young to say "Dada" in this picture-book vehicle for Fallon.
A grumpy bull says, "DADA!"; his calf moos back. A sad-looking ram insists, "DADA!"; his lamb baas back. A duck, a bee, a dog, a rabbit, a cat, a mouse, a donkey, a pig, a frog, a rooster, and a horse all fail similarly, spread by spread. A final two-spread sequence finds all of the animals arrayed across the pages, dads on the verso and children on the recto. All the text prior to this point has been either iterations of "Dada" or animal sounds in dialogue bubbles; here, narrative text states, "Now everybody get in line, let's say it together one more time…." Upon the turn of the page, the animal dads gaze round-eyed as their young across the gutter all cry, "DADA!" (except the duckling, who says, "quack"). Ordóñez's illustrations have a bland, digital look, compositions hardly varying with the characters, although the pastel-colored backgrounds change. The punch line fails from a design standpoint, as the sudden, single-bubble chorus of "DADA" appears to be emanating from background features rather than the baby animals' mouths (only some of which, on close inspection, appear to be open). It also fails to be funny.
Plotless and pointless, the book clearly exists only because its celebrity author wrote it. (Picture book. 3-5)
Categories: CHILDREN'S CONCEPTS | CHILDREN'S FAMILY
Jimmy Fallon Christmas Book Coming This Fall


Achillion Pharmaceuticals Inc.'s (NASDAQ: ACHN) recent interim data for its developmental hepatitis C drug is "incrementally positive," according to JMP Securities' Liisa A. Bayko.
Achillion's Monday data dump is among a half-dozen drug company developments that JMP analysts commented on Tuesday.
Bayko reiterated an Outperform rating and $24 price target on Achillion, but called it a "high risk" clinical plan by the company to use its NS5A inhibitor, ACH-3102, in combination with Gilead Sciences Inc.'s (NASDAQ: GILD) Sovaldi treatment for hepatitis C.
Boston Scientific Corp. (NYSE: BSX) agreement to market C.R. Bard Inc.'s (NYSE: BCR) drug-coated balloon called Lutonix in the U.S. got a thumbs up from JMP's J.T. Haresco.
Hareso reiterated an Outperform rating and $17 target on Boston Scientific, and said the Bard agreement covers part of Boston's strategy for selling a complete array of products aimed at peripheral arterial disease.
Horizon Pharma PLC (NASDAQ: HZNP) is making good with its $45 million October acquisition of the osteoarthritis drug Pennsaid, with sales of the product tracking toward $40 million in annual sales, JMP's Oren G. Livnat said.
Livnat raised his target on Horizon 11 percent to $20 and maintained an Outperform rating on the company, citing a possible earnings surprise Feb. 29.
Organovo Holdings Inc. (NYSE: ONVO) released its first product, 3D human liver tissue in the third quarter, but on Monday posted related revenue of only $155,000 for the period.
Hareso reiterated a Market Perform rating and said he'll wait for more "visibility" on liver revenue.
Pharmacyclics Inc. (NASDAQ: PCYC) released promising data on its Imbruvica drug from a Phase I lymphoma trial. The drug received marketing clearance for a fourth related indication last month.
JMP's Michael King reiterated an Outperform rating on Pharmacyclics along with a $253 target, predicting 2015 sales of $1.4 billion.
Tetraphase Pharmaceuticals Inc. (NASDAQ: TTPH) may benefit from proposed legislation enabling it to transfer to another company one year of market exclusivity on its eravacycline antibiotic candidate.
The proposal, a small piece of the so-called 21st Century Cures bill now before Congress, could make Tetraphase a more attractive buyout candidate, "or alternatively, it could create a source of financing" once eravacycline is approved, according to Bayko.
Bayko maintained an Outperform rating and $58 target on Tetraphase Tuesday.
Reynolds American Inc. Q4 Shipments Fall 5%, Vs 1.7% For Altria Group Inc.


text:
David J. Pintel
Understanding a hijacker
May 13, 2019 By Mariah Cox in Research Tags: Molecular Cytology Core
Figuring out how a virus takes over cells could help with gene therapy
Kinjal Majumder and David Pintel | photo by Roger Meissen, Bond LSC
By Mariah Cox | Bond LSC
When we catch a cold or contract the flu, we usually attribute it to picking up a virus from a friend or someone we know. Our bodies' built-up immune systems have a way of attacking viruses to help us stay healthy, but sometimes viruses can hide.
A study published in eLife by lead researcher Kinjal Majumder, a postdoctoral fellow in the Bond LSC lab of David Pintel, sought to understand where a virus goes when it hijacks a host cell. This basic science may one day help researchers use viruses to better treat human diseases.
In general, when cancer-causing viruses infect a host cell, they translocate their genetic material into the DNA of healthy cells, taking over and causing disease in the host organism.
Majumder and his collaborators developed an experimental system to identify the 'zip codes' within the nucleus where the virus localizes.
"When looking at the mouse DNA in infected cells we noticed that the virus seems to associate with particular sites," Majumder said. "When we mapped where those sites were, we found that the virus localizes to regions of the genome that are prone to DNA breaks. If you unravel all the DNA, which comes out to be about six meters in length, there are very distinct sites where the virus seems to associate."
Through this research, Majumder was able to figure out where the virus goes when it infects a host cell and why it is attracted to those certain locations. These DNA sequence sites are prone to having breaks which is indicated by the presence of DNA repair machinery, making them more vulnerable to viruses. His current research focuses on how viruses hijack these break sites and take over the repair machinery to replicate.
"Viruses are very intelligent," Majumder said. "What we're now trying to do is to understand how they move about in the nucleus. We found out the where, we think we know the why, now we want to know how they know to attach to these sites."
In order to conduct his research, Majumder is using a simple 'test-tube' model virus called minute virus of mice (MVM), which is a rodent parvovirus, to look at host-virus interactions. This model is particularly easy to work with in a lab setting and results are easily transferable to other viruses in animals and humans.
Other cancer-causing viruses that function similarly to parvovirus, such as human papillomavirus (HPV) and hepatitis B, have also been found to integrate into breaks in DNA chains and drive cancer progression.
"There is a close relationship between a replicating virus and the cell's DNA repair machinery which normally protects us from cancer. Now we are starting to see that MVM localizes to the sites in the nucleus which contain a lot of these repair proteins," Majumder said. "It's an interesting phenomenon and we are starting to study the mechanism of how this might be happening."
Majumder adapted an experimental system called chromosome conformation capture assay by chemically cross-linking virus DNA and the cellular DNA that are close together and generating hybrid DNA fragments in a test tube. After sequencing these fragments, Majumder and his team could determine the exact sites that the viruses associated with.
In order to confirm the location of these sites, they used powerful confocal microscopes in MU's Molecular Cytology Core. By using a laser to make a DNA break in a cell, Majumder could also show that virus localized near the induced breaks.
Kinjal Majumder uses a laser to make breaks in a DNA sequence using the confocal microscopes in MU's Molecular Cytology Core. | photo by Roger Meissen, Bond LSC
"If we can figure out how the virus is going to those regions, it opens up the possibility of finding whether other viruses, such as HPV or hepatitis B, utilize similar mechanisms to go to those sites," Majumder said. "Knowing that may help study how oncogenic viruses cause cancer."
Understanding how viruses hijack host cells and utilize cellular DNA breaks may allow future researchers to design improved cancer therapies.
Parvoviruses, in a broader sense, are used in oncolytic therapies to treat cancers using viruses. Cancer cells can arise due to dysregulation of DNA repair machinery in cells. They can also occur due to mutations in DNA breaks that can cause translocations. Parvoviruses have the ability to replicate in cancer cells, which is why they are being used as gene therapy vectors in clinical trials to target cancer.
"Knowing where gene therapy vectors stay long-term and how they interact with DNA repair proteins is important because they can express throughout their lifetime," Majumder said. "For example, if you have cystic fibrosis, you have a mutation in one particular gene, so you don't make specific proteins and as a result, you get a lot of health problems. Gene therapy adds a wild-type piece of DNA to express the correct version of the protein."
For his Ph.D., Majumder looked at how the genome folds upon itself, gets packaged into the nucleus, and how this packaging regulates immune system development. His previous research on the genome is currently helping him advance his work with viruses.
"When I started working with viruses, I realized I could easily utilize those techniques to map how viral DNA interacts with the host's DNA," Majumder said.
Majumder hopes a better understanding of how viruses interact with DNA damage responses will move forward gene therapy.
"If you know how these viruses interact with the host's proteins in the nucleus, you can design more effective gene therapy vectors."
This research was published in the Journal "eLife" in July 2018 and was funded by the National Institute of Allergy and Infectious Disease of the National Institutes of Health.
#IAmScience Maria Boftsi
May 18, 2018 By Allison Scott in #IAmScience Tags: #IAmScience, #MizzouResearch
Maria Boftsi, a Ph. D candidate, stands near her lab station in the Pintel Lab in Bond LSC. | photo by Allison Scott, Bond LSC
By Allison Scott | Bond LSC
Change is hard. Especially when you're comparing weather, like Maria Boftsi, a second year Ph.D. student in the Pintel Lab at Bond LSC, did.
From the sunny skies of a small town in Northern Greece, where she's originally from, to the contrastingly harsh winter of mid-Missouri, Boftsi was in for a lot of change when she came to Mizzou.
"The summer after my third year of undergraduate I came to work in the Sarafianos Lab. Then I went back to Greece to finish my bachelor's degree," Boftsi said. "When he moved to a different university, I joined the Pintel Lab about six months ago."
In the Pintel lab, Boftsi studies parvovirus interactions with the host genome. This virus is among the smallest in terms of DNA.
"We study the parvovirus Minute Virus of mice, or MVM," Boftsi said. "MVM infection leads to a sustained DNA damage response in cells, which the virus exploits to enhance its replication."
The replication process is anything but simple. Boftsi uses previous work to better understand this aspect of the virus life cycle.
"Recent studies in our lab have shown that the virus establishes replication centers at specific sites of the cellular genome," Boftsi said. "I'm trying to investigate the role of viral proteins on virus-host interactions."
Once the lab does that, they'll be able to apply what they've learned to future projects.
"Parvoviruses are important pathogens and cause infections in many animal species," Boftsi said. "Our work can provide important insights into virus-host cell interactions in general."
That kind of impact is what allowed Boftsi's original interest in science to grow.
"I first got into research because of a biology class I had in high school," Boftsi said. "Then I realized how amazing it is to study something closely and learn the details."
And the curiosity she's developed is a driving factor in her decision to keep her education going.
"I want to do a postdoc," Boftsi said. "I really want to continue research."
Even though being thousands of miles away from home is hard, Boftsi has grown from the experience, and she's grateful for the opportunities she's had thus far.
"It's been great. I really like it here," Boftsi said. "The environment is amazing, and the people are so friendly and helpful."
In a viral game, the fight isn't fair
October 30, 2017 By Samantha Kummerer in Research Tags: viruses
Lab explores how parvo wins in tug of war with cells
Kinjal Majumder and David Pintel examine the protein levels in mouse cells during MVM infection. Each black band represents the amount of viral protein in infected cells over time. | Photo by Samantha Kummerer, Bond LSC
By: Samantha Kummerer, Bond LSC
At the start of any tug of war game, the battle is even. But it doesn't stay that way for long. After a back and forth, the inevitable happens — the stronger team gives the rope one last tug and send the losers toppling over, claiming their dominance.
This is a game cells and viruses know well. In their version of tug of war, the virus eventually overtakes the cell and not only topples it but causes a consequence far worse than a few scraped knees.
This is how post-doctoral fellow Kinjal Majumder thinks of the interaction between parvoviruses and the dividing cells it conquers.
Majumder and others in the lab of David Pintel at Bond Life Sciences Center recently gained insight into how the virus achieves victory over the cell. These findings could improve human therapies and even play a role in treating cancer.
Meet the Champion
Parvoviruses are some of the smallest, simplest viruses. With only two genes, it has fewer DNA base pairs than most other viruses, up to ten times smaller in some cases. The virus' size and simplicity, however, do not make it any easier to understand.
Pintel's lab works at the "nitty gritty" level of the virus to study its basic molecular mechanism.
The group understands a little about how the virus operates but is working on the why.
Like a sly culprit, the virus uses its tiny nature to sneak inside the cell. The cell recognizes the presence of the virus as a foreign piece of DNA and responds to try to remove it. Once the cell responds, the virus begins replicating inside until it overtakes the cell. But, the tug of war game ends up more one-sided, so perhaps viewing the virus as a ruthless conqueror would be more accurate.
Majumder's experiments specifically focus on DNA damage response, an intrinsic function of cells. The DNA damage response constantly works to protect us from cancer by continuously repairing broken DNA to prevent harmful mutations in cells . This response uses a network of cellular pathways to monitor and provide checkpoints in the cell cycle to prevent damage from being passed on to the next generation of cells. But parvoviruses also tricks cells to begin a DNA damage response, which they use to eventually take over the host cell.
In July, the lab published the latest finding from a series of papers exploring a type of these parvoviruses called minute virus of mice (MVM). The discovery began when the team found that the virus stops cells from dividing within infected cells.
To do this, MVM uses the DNA damage response to stop cells from dividing, but still allows virus replication to continue. The group developed a system to examine how the virus took over the cell. Further experiments revealed the virus transcriptionally regulates cell cycle genes.
The team used CRISPR to target a cellular gene that the virus must inactivate for it to replicate. Expression of this gene is required for the cell to divide. They discovered the virus actually blocks the transcription of this gene so it cannot make its protein. Blocking this function also prevents the cell from dividing. Without cell division, the virus is free to rapidly replicate inside the cell.
Post-doctoral fellow, Kinjal Majumder, points to the results of a recent experiment. When MVM is mutated at particular sites, the protein levels produced by the virus decrease, but the virus continues to replicate efficiently. | Photo by Samantha Kummerer. Bond LSC
Majumder said parvo's manipulation of infected cell cycles is different from other viruses because it can only replicate in cells that are actively synthesizing DNA. It eventually halts the process of cell division in infected cells by dysregulating transcription factors that regulate cell cycle gene expression. That's what makes this discovery unique.
This discovery only scratches the surface.
Majumder said the lab constantly thinks of new experiments to explore parvovirus biology. The simplicity of its DNA expedites the process of culturing and growing the virus, leaving more time for what Majumder calls the "fun experiments."
"We try to be thorough and confident of our findings, so we attack experiments from many different angles," Majumder said.
Imagine viewing an object from multiple angles under varying light conditions. The change in perspective reveals something different about it with each new look. This approach expands their understanding of parvoviruses.
Majumder explained the lab makes use of everything from high-resolution imaging and CRISPR technology to proteomics and deep sequencing to study the tug-of-war between MVM and the DNA damage response.
"The thing about being a postdoc is you kind of have to be a jack of all trades," Majumder said about his ability to conduct the range of experiments.
Parv O'Lantern: A nucleus of an infected mouse cell is captured using a super-resolution GSD microscope. Parvovirus MVM creates replication centers within host cell nuclei. The viral DNA can be labeled with fluorescent probes for imaging. Viral genomes that haven't made it inside are illuminated on the edge. The viral genomes that have entered made replication centers that resemble the face of a Jack O'Latern. | Photo by Kinjal Majumder and Alexander Jurkevich
While parvoviruses are not a deadly threat to humans, understanding it has major implications for humans.
Parvoviruses are used to develop gene therapy tools to treat disorders like muscular dystrophy and spinal muscular atrophy. The Pintel lab collaborates with labs such as the Lorson and Sarafianos lab in Bond LSC, to explore its therapeutic potential.
Majumder explained the lab is also interested in understanding how the virus could improve cancer treatment. Parvo's tendency to replicate in dividing cells links it to how cells divide uncontrollably in cancer. Majumder explained those scientists are trying to use that function of the virus to target cancer cells.
This makes work in the Pintel lab that much more important. But, before the virus can fully improve humans' conditions, researchers better grasp its capabilities. And that means more of the daily experiments within the Pintel lab.
"What we learn from studying a simple virus can be expanded to more complicated viruses because there are some viruses that can make a dozen different proteins, so that's a more complicated system," Majumder said. "Before you can get to the more complicated systems, you need to be able to understand the one that makes just a few proteins."
For now, scientists will play their own tug of war as they go back and forth in their findings and experiments to uncover the mystery surrounding this small, unique virus.
Sci over Pie with Dave Pintel
March 20, 2015 By Hannah Baldwin in Research Tags: Dave Pintel, Sci over Pie, strawberry rhubarb pie, virology
Big discoveries come in little (capsid) packages
February 12, 2015 By Caleb O'Brien in Research Tags: Bond Life Sciences Center, David Pintel, MU, parvo, parvovirus, virus
Adeno-associated virus type 2 at 3.0 A (xie, et al, Proc Natl Acad Sci U S A. 2002; 99:10405-10.) Courtesy David Pintel
It's an understatement to say viruses are small.
But an average virus dwarfs the diminutive variety known as parvoviruses, which are among the most minuscule pathogens known to science.
Tucked inside a protective protein shell, or capsid, parvoviruses contain a single DNA strand of about 5,000 nucleotides. If parvo's genetic material is like an hour-long stroll around your neighborhood, a bigger virus like herpes is equivalent to walking from St. Louis to Columbia, Missouri.
Dr. David Pintel stands next to a scan in his lab in Bond Life Sciences Center on Tuesday, Feb. 3, 2015. Hannah Baldwin/Bond LSC.
"I joke that we can do the whole parvovirus genome project in an afternoon, because it's just taking it downstairs and having it sequenced," said David Pintel, a Bond Life Sciences Center virologist and Dr. R. Phillip and Diane Acuff endowed professor in medical research at the University of Missouri. "It's the size of one gene in the mammalian chromosome."
But that little stretch of DNA still has plenty of tricks up its sleeve.
Pintel has spent nearly 35 years studying parvo and is one of the world's foremost experts on the virus, but he's still plumbing the tiny pathogen's depths.
His lab focuses on unraveling how parvo interferes with a host cell's lifecycle and understanding the virus' quirky RNA processing strategies.
"Even though the virus is small, it's not simple," David Pintel said. "Otherwise we'd be out of business."
Over the last two decades, parvo has become an important tool for gene therapy, an experimental technique that fights a disease by inactivating or replacing the genes that cause it. Researchers enlist a kind of parvovirus known as adeno-associated virus as a gene therapy vector, the vehicle that delivers a new gene to a cell's nucleus. Pintel helped suss out the virus' basic biology, an important step for developing effective gene therapy.
A varied virus
The name 'parvo' comes from the Latin word for 'small.' But the virus' size makes it a resourceful, versatile enemy and a valuable model for understanding viruses and how they interact with hosts.
Parvoviruses fall into five main groups. They infect a broad swath of animal species from mammals such as humans and mice to invertebrates such as insects, crabs and shrimp.
Canine Parvovirus at 2.9 A (Tsao, et al, Science. 1991; 251:1456-65.) Courtesy David Pintel.
Canine parvovirus, or CPV, is perhaps the best-known type.
It targets the rapidly dividing cells in a dog's gastrointestinal tract and causes lethargy, vomiting, extreme diarrhea and sometimes death. In humans, Fifth disease, caused by parvovirus B19, is the most common. This relatively innocuous virus usually infects children and causes cold-like symptoms followed by a "slapped cheek" rash. There is no vaccine for Fifth disease, but infections typically resolve without intervention.
Reading the transcript
Pintel surveyed the whole parvo family to understand its idiosyncrasies.
To study bocavirus – a kind of parvo recently linked to a human disease – Pintel looked closely at the dog version, minute virus of canines (MVC). MCV serves as a good model for the human disease-causing virus. While examining MVC, he noticed an unexpected signal in the center of the viral genome. The signal terminates RNA encoding proteins for the virus' shell, a vital part of the pathogen.
Finding such a misplaced signal in the middle of a stretch of RNA is like coming across a paragraph break in the middle of a sentence.
Pintel knew the virus bypassed this stop sign somehow, because the blueprint for the viral capsid lies further down the genome.
To overcome this stop sign, this particular parvovirus makes a protein found in no other virus. The protein performs double-duty for the virus: It suppresses the internal termination signal and splices together two introns, or segments of RNA that do not directly code information but whose removal is necessary for protein production. Splicing the introns together ensures that the gene responsible for producing the viral capsid is interpreted correctly.
Viruses and hosts: a game of cat and mouse
The conflict between a virus and a host is a constantly escalating battle of assault and deception.
Viruses need a host cell's infrastructure to replicate, but have to fool or outmaneuver its defenses.
Pintel discovered one example of this trickery in mice, where parvo triggers a cellular onslaught known as the DNA damage response, or DDR. This type of parvo co-opts that defense. Normally DDR pauses the cell cycle to keep damaged DNA from being passed on to the next generation of cells, but parvo exploits that delay, buying time for the virus to multiply.
"For many, many hours the cells are just held there by the virus while the virus continues to replicate," Pintel said. "And then that cell never survives; the virus kills the cell. It's that holding of the cell cycle — which is part of the DNA damage response — that the virus hijacks to hold the cell cycle. It's really cool."
Parvo's small size makes it especially beholden to their hosts. But that can make them particularly revelatory for researchers.
Parvovirus samples from an experiment labeled by Femi Fasina, a postdoc in Pintel's lab. Caleb O'Brien/Bond LSC.
"It's a twofold thing," Pintel said, "Because it's a virus that's dependent on the cell, when you learn how the virus is doing these things, you learn how the cell does those basic processes. If we're looking at a viral-cell interaction, yes, we're looking at it from a viral point of view, but on the other hand we're trying to understand the basic cellular process."
Uncovering such nuanced interactions is a painstaking, laborious process that often goes unheralded by mass media. But those fundamental discoveries provide the building blocks upon which other researchers depend, said Femi Fasina, a postdoc in Pintel's lab.
"When you understand basic biology, people can walk on those advancements. Although we don't see the impact immediately, such things lead to breakthroughs that will revolutionize a lot of things."
A small question
Despite his deepening understanding of how parvo works, there remains one debate about the virus that Pintel deems beyond the scope of his research: Are the tiny slivers of DNA that comprise parvoviruses even alive?
"I think that's a crazy question," he said. "It's semantics. The virus is a genome. It goes into a cell, it doesn't do anything until it's inside of a cell and then it does stuff." So whether you write parvoviruses into the book of life depends entirely on how you define the word 'alive.'
"I put that in the realm of philosophy," Pintel said, "not the realm of science."


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text:
Nestling at the foot of the Kuruman Hills, this is the biggest town in the Kalahari with an atmosphere pleasantly balanced between frenetic and laid back.
It is known as the 'Oasis of the Kalahari', obtaining its fertile slogan from the abundance of subterranean water that bubbles to the surface at the 'Eye'. This fountain produces 20-million litres of crystal clear water daily. The N14 becomes the main thoroughfare through town, and the majority of the CBD is centred on the roads to the north.
With a diversity of shops, the town is a major supply point for visitors heading deeper into the wilderness. Besides The Eye, there are a number of other sites worth spending time at. Moffat Mission on the outskirts of town is where the history of the region is most tangible. The atmosphere amongst the trees and old buildings is serene. For more ancient history, a visit to the Wonderwerk Cave on the R31 south of town provides a lot to contemplate with regards to the first peoples who lived in our country.
The Eye - in town alongside the main street the fountain is situated in park-like surrounds with tall trees shading the grass verges. Discovered in 1801, the freely flowing water brings life to the town and surrounding area, and supports a host of fish including an endangered Cichlid (Pseudocrenilabrus Philander).
Moffat Mission - is located 5kms north of town off the R31. Here the stone church, old homesteads, and buildings of traditional mud-plaster slumber in the shade of ancient trees. The mission exudes an atmosphere of spirit-reviving tranquillity. Romantics might like to know that in its gardens explorer David Livingstone proposed to his wife Mary. It was also his first home in Africa.
Wonderwerk Cave - 43kms south of Kuruman on the R31 to Daniëlskuil, this cave has a history covering almost a million years. The 140m deep cavern has sheltered people from many different cultures through the ages. Extensive excavations have been done in the cave, and the artefacts recovered are on display in the McGregor Museum in Kimberley.
Bird Sanctuary and Nature Reserve - The 2000ha reserve has a surprising variety of game and birdlife.
4x4 near Kuruman


LT Johnson's commentary on Romans deals with the question in some depth. It's a very good commentary in general.
too, Dunn's commentary in the Word Biblical Commentary series.
Michael Gorman has 2 chapters in Cruciformity: Paul's Narrative Spirituality of the Cross (2001) on "Cruciform Faith". The first deals more with the faith of Christ, and the second deals more with believers who have faith in Christ. Or, as I prefer to think of it, believers who possess the faith of Christ -- for, as Gorman says, our faith is both a response to and a sharing in Christ's faith. Which means we can't really talk about faith in Christ without talking about the faith of Christ.
An African student at Southern Seminary wrote his dissertation under Tom Schriener on this very subject. In a conversation with him, I believe he said that it should be "faith in" instead of "faith of." I will try to track down his name and dissertation title. He teaches in Cameroon.
I'll follow up that Johnson commentary, Chris, as I have the rest (Dunn's commentary is probably my favourite on Galatians).
Dan, not long before you wrote these words, I had just made my notes on Gorman. Quite helpful.
I'd be very grateful, Alan, thanks.
If his doctoral work was with Tom Schreiner, I would expect it to be taking the 'faith in' line, as, like Tom, it is more traditional.
Chris, Thomas Tobin has some stuff in favour on an objective genitive interpretation in his book: The Rhetoric of Righteousnes. Try books by Schreiner and Seifrid too.
Far and away the best book on this subject is 'The Faith of Jesus Christ' by Richard Hays. The second edition (2003 I think) has a useful debate between Dunn ('faith in') and Hays ('faith of') which covers most of the main points of discussion of this issue in Paul.
Thanks Mike for the Thomas Tobin tip, and your own blog article. Very useful.
Hi Steven, thanks for visiting. I love your blog.
I do have Hays' book actually, but it is an older print. Is there much additional material in the 2003 edition?
I still feel that I might as well toss a coin about my conclusion, however. I find the argument finely balanced. However, I really ought to make an exegetical decision on this one - and not cop out like I've done with the North/South Galatia issue!
well, why not make the decision by way of a completely original argument drawing on a largely irrelivant piece of theory imported from some obscure PhD in another field of...?
Amen Eddie!! Just call it 'social-scientific' and its bound to work!
The original version of Hays' book was in the SBL dissertation series. The latest edition (2001 I think) has the same content but it has a very useful and lengthy appendix containing a debate between Hays and James Dunn on how best to translate 'faith' in Paul, and they manage to discuss texts that were outside the scope of Hays' original thesis.


text:
Teodoro J. Buhain (* 4. August 1937 in Bacoor) ist emeritierter Weihbischof in Manila.

Leben
Teodoro J. Buhain empfing am 21. Dezember 1960 die Priesterweihe. Papst Johannes Paul II. ernannte ihn am 5. Januar 1983  zum Titularbischof von Bacanaria und zum Weihbischof in Manila.

Der Apostolische Nuntius auf den Philippinen, Bruno Torpigliani, spendet ihm am 21. Februar desselben Jahres die Bischofsweihe; Mitkonsekratoren waren Oscar V. Cruz, Bischof von San Fernando, und Amado Paulino y Hernandez, Weihbischof in Manila.

Von seinem Amt trat er am 23. September 2003 zurück.

Weblinks

Römisch-katholischer Bischof (21. Jahrhundert)
Römisch-katholischer Bischof (20. Jahrhundert)
Philippiner
Geboren 1937
Mann

redpajama_set_name: RedPajamaWikipedia


text:
ASIATIC IMMIGRATION.
Mr. H. H. STEVENS (Vancouver) moved for leave to introduce Bill No. 227, to amend, the Immigration Act. He said: The House and the country are well aware of the difficulties which we have been encountering for a number of years past in dealing with immigration from the continent of Asia. At the present time we have three methods of dealing with this question. Japanese immigration is controlled by an amicable arrangement between the two governments; 'Chinese immigration is subject to a head tax of $500, and Hindu immigration comes under an Order in Council which provides that immigrants can only come by direct route to this country. This provision has for some time more or less effectively stopped this immigration. However, there has /been a great real of dissatisfaction. It has been recognized that the regulations now in force are more or less of a temporary character, and there is a general demand throughout the country, especially in the province from which I come, that the Dominion Government shall take some definite and final action towards the regulation and restriction of Asiatic immigration. The objections to exclusive regulations are based largely upon the desire of this Government, and the people of Canada as a whole, not to do anything which might offend the dignity of other peoples by specifying exclusion. In this sentiment I heartily concur, but it appears to me, and I think the events of recent years, especially those of the last month or so, have amply demonstrated that this is a case where we have to choose between two evils. One is the possibility of causing some slight offence to these people from across the seas, and the other is unrestricted Asiatic immigration into this country. We cannot go on with the temporary expedients which have been in force for the last few years. There are other reasons why more stringent immigration regulations have not, up to this time, been adopted. For instance, there is the imperial reason, and it is one which is of very great importance, but in that regard I would like to point out a principle which I think we should hold more dearly than any other principle of government, and that is that we, the people of the Dominion, or the people of any of the overseas dominions, or, to to control immigration into this country, have a right to control the immigration into their own country. I base my proposal on the principle that it is our right to control immigration into this country. We axe not bound to extend the privileges of our country to every one who cares to come. It is not a right on the part of immigrants to enter this country, but it is our right to restrict *whatever immigration we desire. For this position I have a very high authority. Lord Curzon, in discussing the Hindu immigration problem, has declared that: The common rights of British citizenship cannot be held to override the rights of self-protection conferred on a self-governing colony. That is exactly where I stand. I urge upon Parliament and upon the Government to take a firm stand upon that principle. Now-
Some hon. MEMBERS:
Topic: ASIATIC IMMIGRATION.
Thomas Simpson Sproule (Speaker of the House of Commons)
Order; I am afraid that the hon. member is rather going beyond what is permissible, that is, merely to explain the principle of the Bill.
utr.17
Henry Herbert Stevens
Mr. STEVENS:
I am simply offering this explanation to the House, as a reason for the introduction of this Bill. The Bill provides for an amendment to section 3 of the Immigration Act, which is the clause under which we exclude certain classes of people, for instance, the physically unfit, etc. I purpose by this Bill to add a clause to section 3 of the Immigration Act, which will exclude all natives and naturalized citizens of countries in Asia, south of the 50th parallel of north latitude, provided, however, that this clause shall not apply to any country the government of which has a specific arrangement with the Government of Canada. In other words, we fix the principle of excluding immigrants from Asia, but if the Government of a country in Asia wishes to enter into an arrangement with our Government in order to protect their national dignity, we leave the door open for them to do so.
I urge this Bill upon the attention of the Government, and if possible I should like to see it passed this session. Possibly there may have to be representations made to the Home authorities with respect to it, and if it should be found consequently impossible to pass it this session, then I urge upon the Government that they should make strong recommendations to the Home authorities, with regard to this very important matter, so that this Bill may pass at the next session.
Wilfrid Laurier (Leader of the Official Opposition)
Sir WILFRID LAURIER:
My hon. friend has introduced this Bill when, as everybody knows, we are so near prorogation that it is expected we shall be able to finish all the business before us within the present week. The hon. gentleman is aware that, even if we had a month or six weeks still remaining of the session, it would be impossible to press this Bill through. The Bill, of course, cannot be taken up at all without the consent of the Government, and it would be interesting to know whether the Government intends to adopt this Bill and to support its passage.
Robert Laird Borden (Prime Minister; Secretary of State for External Affairs; President of the Privy Council)
Mr. BORDEN:
I was not aware of the terms of the Bill until my hon. friend (Mr. Stevens) told the House of them just now, nor was I aware of his intention to move to introduce the Bill. I was very much occupied with some other matters while my hon. friend was making his explanation, but I shall look it over in ' Hansard,' and give an answer later to the right hon. gentleman. -
You will keep considering it until Doomsday.
Motion agreed to, and Bill read the first time.
(Questions answered orally are indicated by an asterisk.)
LAST RAILWAY LAND GRANT.
James Joseph Hughes
Mr. J. J. HUGHES:
Topic: QUESTIONS.
Subtopic: LAST RAILWAY LAND GRANT.
Charles Joseph Doherty (Minister of Justice and Attorney General of Canada)
Mr. DOHERTY:
So far as a careful
search by the departmental officers shows, the last statute passed by the Parliament of Canada authorizing a girant of land to a railway company is the National Transcontinental Railway Act, 3 Edward VII, chapter 71, section 14. 'See also section 46 of the agreement scheduled thereto. The above was a grant of land for right of way purposes. The Railway Lands Branch of the Department of the Interior report that the last statute passed by the Parliament of Canada authorizing a grant of land to a railway company by way of subsidy is chapter 6 of 57-58 Victoria, 1894.
By chapter 55, section 6, subsection c, Revised Statutes of Canada, the Governor in 'Council i3 authorized to make a free grant of land not exceeding in extent six thousand four hundred acres for each mile of railway within Manitoba, and not exceeding in extent twelve thousand eight hundred acres for each mile beyond the limits of Manitoba, in aid of the construction of a railway from some point on the Canadian Pacific railway to Hudson hay.
AGRICULTURAL AID IN SHERBROOKE.
Francis N. McCrea
Mr. McCREA:
What was the total amount of money paid out in the county of Sherbrooke during the last fiscal year for agricultural purposes, to whom was it paid and how much to each person or society ?
Subtopic: AGRICULTURAL AID IN SHERBROOKE.
Martin Burrell (Minister of Agriculture)
Mr. BURRELL:
J. H. M. Parker, Lennoxville, Quebec, $65; I. J. Parnell, Lennoxville, Quebec, $10.
These payments were in connection with the purchase of pure-bred rams for distribution to associations of farmers.
Field crop competitions held in August, September and October, 1913, paid to Sherbrooke Agricutural Society for the province of Quebec, $50.
Seed Fair held at Sherbrooke, February 10, 1914, paid to ISherbrooke Agricultural Society for the province of Quebec, $50.
Salary and travelling expenses of Mr. COMMONS
Carl Sweet, district representative for the English-speaking counties in the province of Quebec, with headquarters at Sherbrooke, $2,200.30.
The following payments have been made in connection with the purchase of the experimental station at Lennoxvile, Quebec: F. Campbell and E. W. Reid, $15,000; F. Campbell and W. H. Pearson, $12,000; F. Campbell and C. F. Carter, $2,300; F. Campbell and H. Bennett, $2,800; F. Campbell and W. J. Douglas, $3,750; F. Campbell and Ed. Reid, $5,000; R. W. Reid, $700; Ed. Reid and F. Campbell, $5,000; Graham Bros., $39.08; Robert Westgate & Son, $260; veterinary inspector, J. E. Beaudry, Sherbrooke, P.Q., salary, $1,400; C. White, Len-noxville, P.Q., salary, $100. Total expenditure, $50,724.38.
GROSSE ISLE QUARANTINE STATION.
Mr. BOURASSA:
1.	Was Come Langlois, of Bienville, Lfrvis, captain of vessel at Grosse Isle, dismissed by the Government, or did he tender his resignation?
2.	If dismissed, when and why?
3.	If he resigned, what reasons were given by him for so doing?
4.	By whom was he replaced?
Subtopic: GROSSE ISLE QUARANTINE STATION.
Mr. BURRELL: (Minister of Agriculture)
1.	Resigned.
2.	Answered by No. 1.
3.	Ill health.
4.	The vacancy caused in the service by Captain Langlois' resignation was filled by the appointment of Depris Couillard.


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Read: Highlights
Opinions: American Politicians Speaking on the Status of Cryptocurrency in the Future
With the development of blockchain technology, the question arises as to what status the cryptocurrency will take in the world financial system in the future
Will cryptocurrency be forgotten in the future? Will it become a new reserve currency? What will the authorities of countries do?
Let's start with the USA. We can't definitely say what US President, Donald Trump think about bitcoin and other cryptocurrencies. We remember only that the White House Press Secretary, Sarah Sanders said six months ago for the first time that the administration is 'monitoring' bitcoin.
She also added :
I know this is something that is being monitored by our team here. In terms of specific briefings and announcements on it, I don't have anything that I can share with you right now but would be happy to follow back up with you.
Sarah Sanders, the White House Press Secretary
Stephen Bannon, the previous chief strategist to President Donald Trump, believes that the cryptocurrency industry has a potential to disrupt the banking sector.
It was pretty obvious to me that unless you got somehow control over your currency, all these political movements were going to be beholden to who controlled the currency. I don't believe we should have a bailout. I think the bailouts in 2008 were wrong. And I think, you look in hindsight, it was a lot of misinformation that was presented about the bailouts of the banks in the West.
Stephen Bannon, the previous chief strategist to President Donald Trump
Gary Cohn, the former Goldman Sachs executive who led Donald Trump's National Economic Council until last month, weighed in on bitcoin and blockchain technology.
I'm not a big believer in bitcoin, I am a believer in blockchain technology. I do think we will have a global cryptocurrency at some point.
Gary Cohn, the former Goldman Sachs executive
In the recent news, we could see that Ron Paul who ran for the US presidency on the Libertarian party acknowledged:
It's a fallacy to believe the US has a free market economy. The economy is run by a conglomerate of individuals and special interests, in and out of government, including the Deep State, which controls central economic planning.
Ron Paul, the former presidential candidate and US Representative
However, the moot point remains the same — the President is yet to express his views on blockchain and cryptocurrencies.
BTCUSASarah SandersStephen BannonGary CohnGoldman SachsRon PaulCommunity leaders


Three boats took to the water for the morning series race with under a second separating the first two boats at the finish.
Fifteen boats took to the water in the afternoon to race with several more enjoying the sailing conditions.
Well done to Heather McPhee who accepted the commodore's suggestion that she might like to be Race Officer rather than assistant Race Officer for the day.


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