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Framing Ethical Concerns and Attitudes towards Human Gene Patents in the Chinese Press
Framing Ethical Concerns and Attitudes towards Human Gene Patents in the Chinese Press Du, Li; Lin, Sijie; Kamenova, Kalina 2020-09-01 00:00:00 This study examines the representations of human gene patents in Chinese newspapers. We conducted a qualitative content analysis of news articles published between 2006 and 2017 to identify the major themes in media coverage, ethical considerations, perceptions of risks and benefits, and attitudes towards the patentability of human genes. The results show that two key ethical concerns were expressed by journalists: (1) that it is morally wrong to own or patent human genes and (2) that gene patents could potentially impede patients' access to healthcare services. Nonetheless, the press coverage has tended to be largely favorable (57.8%), rather than opposed (17.8%) to human gene patenting. There were no normative claims that human genes should not be patentable in China, which indicates a generally positive attitude towards patentability in media discourse. Most articles that expressed criticism toward gene patenting discussed challenges in other countries, with significant attention given to the United States Supreme Court's ruling in the Myriad case that invalidated Myriad Genetics' patents on the BRCA1 and BRCA2 genes. Overall, the newspapers were uncritical of the Chinese gene patenting regime. News reporting on the issue was highly suggestive of a strong pro-commercialization stance, although some discussions emphasized potential risks over benefits. Our analysis highlights the need for balanced media reporting on human gene patents in China and a top-down approach to engage the public in substantive discussions on the ethical and societal implications of the existing patent regime. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Bioethics Review Springer Journals http://www.deepdyve.com/lp/springer-journals/framing-ethical-concerns-and-attitudes-towards-human-gene-patents-in-7kjXEfqAVx
Du, Li; Lin, Sijie; Kamenova, Kalina
Asian Bioethics Review
, Volume 12 (3) – Sep 1, 2020
/lp/springer-journals/framing-ethical-concerns-and-attitudes-towards-human-gene-patents-in-7kjXEfqAVx
Asian Bioethics Review /
Springer Journals
Copyright © National University of Singapore and Springer Nature Singapore Pte Ltd. 2020
This study examines the representations of human gene patents in Chinese newspapers. We conducted a qualitative content analysis of news articles published between 2006 and 2017 to identify the major themes in media coverage, ethical considerations, perceptions of risks and benefits, and attitudes towards the patentability of human genes. The results show that two key ethical concerns were expressed by journalists: (1) that it is morally wrong to own or patent human genes and (2) that gene patents could potentially impede patients' access to healthcare services. Nonetheless, the press coverage has tended to be largely favorable (57.8%), rather than opposed (17.8%) to human gene patenting. There were no normative claims that human genes should not be patentable in China, which indicates a generally positive attitude towards patentability in media discourse. Most articles that expressed criticism toward gene patenting discussed challenges in other countries, with significant attention given to the United States Supreme Court's ruling in the Myriad case that invalidated Myriad Genetics' patents on the BRCA1 and BRCA2 genes. Overall, the newspapers were uncritical of the Chinese gene patenting regime. News reporting on the issue was highly suggestive of a strong pro-commercialization stance, although some discussions emphasized potential risks over benefits. Our analysis highlights the need for balanced media reporting on human gene patents in China and a top-down approach to engage the public in substantive discussions on the ethical and societal implications of the existing patent regime.
Asian Bioethics Review – Springer Journals
Published: Sep 1, 2020
Du, L., Lin, S., & Kamenova, K. (2020). Framing Ethical Concerns and Attitudes towards Human Gene Patents in the Chinese Press. Asian Bioethics Review, 12(3), 307-323.
Du, Li, Sijie Lin, and Kalina Kamenova. "Framing Ethical Concerns and Attitudes towards Human Gene Patents in the Chinese Press." Asian Bioethics Review 12.3 (2020): 307-323.


I was surprised when Polly said he wasn't very happy here.
Hans and Saul are sitting in the living room talking.
What should I tell Danielle?
Barry is a spoiled child.
Rajarshi didn't think that it would take a long time to complete the project.
Caroline doesn't eat a balanced diet.
I've already talked to Ned.
Roman might not know how to speak French.
Pat told Sean what John did for a living.
Sanford won't give you any trouble.
Monica piled everything up in the center of the room.
Marci and Steven fell in love with each other at first sight.
Duane says that he wants to live a simple and happy life.
You're such a good boy, Varda!
Torsten is chatting with Nancy.
Tuna is always meticulously dressed.
Kathryn and Dylan's little girl is starting to take her first tentative steps.
Peggy can't get his car to start.
I was with Bret all day.
This was in Neal's safe.
I don't want to remember Lum that way.
Shirley found it more and more difficult to ignore the pain.
Jeany won't be back till tomorrow.


and then promptly chose to extract back out again in order to play it?!
could give you a better idea of what was happening.
> sounds from waves to mp3 directly and everything seems ok to control it.
> Do you know what am I doing wrong with SWFExtract?


Genentech dominated the headlines with its "souped-up" breast cancer drug at the big American cancer meeting in the spring. Now it's making headlines again this fall at a European cancer meeting with some new details about the drug.
The South San Francisco-based biotech company said today that its experimental drug trastuzumab emtansine (T-DM1) was able to extend lives in a study of 991 women with breast cancer that overexpresses the HER2 protein, and who have previously been treated with the original trastuzumab (Herceptin) and a taxane chemotherapy. People who got the new drug lived a median time of 30.9 months, compared with 25.1 months for those who were randomly assigned to get GlaxoSmithKline's lapatinib (Tykerb) and Roche's chemo drug capecitabine (Xeloda). Researchers reported that about 40.8 percent of patients suffered moderate to severe side effects on the new drug, compared with 57 percent in the comparison group.
The 5.8 extra months of median survival time is significant by cancer drug development standards, and the trial results are now the centerpiece of applications for approval in the U.S. and Europe. The drug is important for Genentech as the first in a new wave of antibody-drug combo molecules that are designed to be more potent than conventional targeted antibodies, and because the product should build on its success with the original trastuzumab (Herceptin). The product is also being closely watched by Waltham, MA-based ImmunoGen (NASDAQ: IMGN), which provided Genentech a technology license to help develop T-DM1, and it stands to collect a royalty on worldwide sales of the drug.
The new drug has created a lot of buzz this year, after researchers reported in June at the American Society of Clinical Oncology that the drug met its main goal of slowing the spread of tumors. The trends at that time suggested the drug would also extend lives, but researchers said more follow-up time was required before the full statistical analysis could be done. The final survival data was presented today at the European Society of Medical Oncology in Vienna, Austria.
Simos Simeonidis, an analyst with Cowen & Co., said in a note to clients that he expects the drug to win FDA approval by the end of February, when the agency has a deadline to complete its review. Genentech has already reported that the drug showed a survival advantage in the trial, but today's presentation is the first time it has disclosed the magnitude of the benefit compared with standard treatments.
"The robustness of the data, resulting in almost a 6-month improvement in overall survival, is one more datapoint supporting our view of T-DM1 as a very active drug, with an improved safety profile," Simeonidis said.


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Le Sucre est un film français réalisé par Jacques Rouffio, sorti en 1978, adaptation du livre homonyme de Georges Conchon.

Synopsis
Le film relate une affaire d'escroquerie, sur la base de la bulle spéculative sur le marché à terme des matières premières, en l'occurrence celle du sucre de 1974. Un petit épargnant, Adrien Courtois (Jean Carmet), y perd tout l'héritage de sa femme. Le vicomte Raoul-Renaud d'Homécourt de la Vibraye (Gérard Depardieu) est un courtier fantasque et sans scrupules. Entre les deux hommes, si différents, va naître une amitié et une complicité.

Autour de ce couple gravitent des personnages savoureux : Karbaoui (Roger Hanin), l'homme d'affaires pied-noir exubérant et magouilleur ; Grézillo (Michel Piccoli), patron de l'industrie sucrière et mégalomane, une pharmacienne de province, madame Courtois, d'abord austère et introvertie puis qui « explose » avec l'arrivée de la fortune.

Fiche technique
 Titre : Le Sucre
 Réalisation : Jacques Rouffio
 Scénario : Jacques Rouffio (scénario) et Georges Conchon (scénario et dialogues, d'après son livre éponyme)
 Assistant réalisateur: Philippe Lopes-Curval et John Lvoff
 Photographie : René Mathelin
 Son : William-Robert Sivel
 Décors : Jean-Jacques Caziot, Claude Lenoir
 Musique : Philippe Sarde
 Montage : Geneviève Winding
 Production : Lise Fayolle, Giorgio Silvagni
 Sociétés de production : Cinéproductions, SFP Cinéma
 Dates de tournage :  -
 Pays d'origine : France
 Format : Couleurs - 35 mm
 Genre : comédie satirique
 Durée : 104 minutes
 Date de sortie : ,

Distribution
 Jean Carmet : Adrien Courtois
 Gérard Depardieu : Raoul-Renaud vicomte d'Homecourt de la Vibraye
 Nelly Borgeaud : Hilda Courtois
 Roger Hanin : Roger Karbaoui
 Marthe Villalonga : Madame Karbaoui
 Michel Piccoli : Grezillo
 Claude Piéplu : le président Bérot
 Tony Taffin : Flanqué, directeur de la Bourse
 Pierre Vernier : Latoussaint, banquier
 Georges Descrières : Vandelmont
 Jean-Paul Muel : Pergamont
 Jean-Claude Dreyfus : Mimine
 Jean Champion : le ministre du Commerce
 Maurice Chevit : M. Lomont
 Mathé Souverbie : Mme Lomont
 Laurent Spielvogel : ?
 Etienne Draber :  Le docteur qui perd sur le sucre l'argent gagné sur la laine.
 Dominique Bernard
 Georges Lescuyer : l'homme pointilleux sur le règlement
Georges Conchon : Le directeur des impôts et contributions (également scénariste et dialoguiste)

Distinctions

Dans la culture populaire
Le personnage du "vicomte Raoul d'Homecourt de la Vibraye" s'inspire de la vie d'un agent de change, Roland Gadala, dont le rôle fut prépondérant dans l'ascension du capitaine d'industrie, François Pinault. Son nom apparaît également dans Mon beau-frère a tué ma sœur, interprété par Jean-Pierre Bisson. Au début du film, Depardieu sort d'un immeuble de l'avenue Delessert à Paris. Or Benjamin Delessert s'est rendu célèbre sous le Premier Empire en développant la méthode d'extraction du sucre de la betterave qui avait été inventée par Jean-Baptiste Quéruel. Il a reçu pour cela le titre de baron d'Empire.

Notes et références

Liens externes

 Le Sucre en streaming sur Internet Archive.

Film français sorti en 1978
Thriller (film) français
Comédie française
Film réalisé par Jacques Rouffio
Film avec une musique composée par Philippe Sarde
Escroquerie au cinéma
Film sur la finance
Adaptation d'un roman français au cinéma

redpajama_set_name: RedPajamaWikipedia


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Oil majors gushing in cash despite cheap crude
Posted on August 3, 2017	0 Comments0
The prospect of crude remaining near the current $50 level is no longer a doomsday scenario for the world's oil majors whose latest earnings announcements show that cost-cutting lets them turn a profit even at these price levels.
BP, Chevron, ExxonMobil, Shell and Total have all published results in recent days, showing they pocketed $23bn in net profit in the first half fo the year.
Either they increased their earnings or at least returned to profit compared with the same period last year.
With the exception of ExxonMobil they all benefitted from an increase in output from the same period last year, but more importantly, they all profited from a rebound in crude prices as OPEC members and Russia agreed to limit production.
The price of the international benchmark Brent crude averaged $51.7 per barrel in the first half of this year, up considerably from $39.8 during the same period last year.
While the profits are still less than half of what the firms turned in during the same period three years ago when Brent was trading at over $100 per barrel, they show that the major firms can survive profitably if crude prices stay at current levels, a scenario many now foresee.
"It is a tough environment and it could remain that way for some time," said BP's chief executive Bob Dudley earlier this week.
"But we are building a business that is resilient to these changing conditions," he said.
After crude prices began their descent in 2014 the oil majors reacted quickly: cutting costs, selling off assets judged non-strategic and focusing on the projects they considered the most profitable.
"Big Oils are showing strong ability to adapt to lower oil prices through cost cutting," said analysts at US investment bank Goldman Sachs in a recent report.
By one measure, free cash flow — or the amount of funds a firm has left over after investments needed to maintain or expand their assets — they may even be better off.
Goldman Sachs analysts said European oil majors had a higher cash flow in the first half of this year than in the first half of 2014 when crude prices were more than double of what they are today.
– Lower, forever –
"Recent results are good news and average production costs have fallen by 40 percent since 2014," said David Elmes, and energy specialist and professor at Warwick Business School.
"The important part of recent results is how firms are back to generating enough cash to cover such costs" like investment and high dividend payments that have kept many long-term investors on board, he told AFP.
While cheap oil was initially viewed as a phase that would soon pass relatively quickly as global demand continued to climb upwards, a shift has occurred and many now see lower prices as here to stay for a while.
Shell's chief Ben van Beurden said the firm is now working with a "lower forever mindset".
He said that Shell still believes there is a better than 50-50 chance that crude prices will trend higher in the coming years, but wasn't going to base its business decisions on that.
"We do not want to have the mindset that higher oil prices are around the corner to help us out," he said.
For the moment, the oil majors have shelved costly projects like extracting crude from Canadian tar sands or tapping certain Arctic fields.
However, in the future, they will have to face replacing their reserves at a profitable cost, something which may prove difficult in the medium term.
"The amount of affordable oil and gas big oil can access is limited," said Elmes. "Much is in the control of national oil companies keen and able to develop it themselves."
And when it comes to exploiting shale reserves in the United States, Elmes said that the smaller companies have shown themselves to be able to better control costs.
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Oil majors brace for further dip in prices
NNPC remits N1.26tr to Federation Account
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redpajama_set_name: RedPajamaCommonCrawl


OKLAHOMA CITY (AP) — Jury selection is underway for an ex-Oklahoma zookeeper and former candidate for governor who's charged in an attempted murder-for-hire plot.
Prospective jurors in the trial of Joseph Maldonado-Passage were questioned Tuesday in a federal court in Oklahoma City. Testimony is scheduled to start March 25.
Maldonado-Passage was indicted in September for allegedly trying to hire someone to kill the operator of a Florida-based animal sanctuary. He has pleaded not guilty.
He is also accused of killing five tigers in October 2017 and selling and offering to sell tiger cubs in violation of the Endangered Species Act.
Known as "Joe Exotic," Maldonado-Passage formerly operated a zoo in Wynnewood, Oklahoma. He ran unsuccessfully for Oklahoma governor last year as a Libertarian candidate and appeared on John Oliver's "Last Week Tonight" when he was a 2016 write-in candidate for president.


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COVID-19 Crisis Highlights the Value of Agile Auditing
Brian Christensen, Managing Director Global Leader, Internal Audit and Financial AdvisoryView All Posts
Sharon Lindstrom, Managing Director, Internal Audit Manufacturing and Distribution Industry Practice LeaderView All Posts
Like nearly every other profession in the business world, internal auditing (IA) has been forced to cope with the extraordinary environment brought about by COVID-19. Skills and tools that IA has been adopting gradually over the past several years suddenly become critical for successful performance. And perhaps none is more critical than Agile auditing.
As part of our ongoing Enterprise Resilience webinar series, we examined the advantages of Agile auditing in this particularly challenging time in a recent webinar, Applying an Agile Mindset and Auditing in a Dynamic Environment. Our discussion dealt with three basic areas: What internal auditors need to do right now; what challenges they are likely to face in the short term; and what to look forward to in the long term, when the crisis is behind us but reality may be different.
With regard to immediate needs, the question we as internal auditors are asking ourselves right now is, "How can we be most helpful at this moment?" We have to be able to move at the speed of risk, which, as we've seen from the past several weeks, can be lightning fast.
Clearly, this involves a role change from the traditional IA model of developing checklists, evaluating data and formulating risk assessment. Instead, the internal audit voice now finds itself at front-line meetings more frequently. Auditors should put aside worries about violating independence standards for internal audit when providing consulting to the second and first lines of defense and see themselves less as an assurance provider and more as a proactive partner. In essence, we have to become part of the response team.
The immediate demands of IA also include how we deliver reporting. Directors and executives now require a higher level of risk management visibility across the organization. Here too, agility can play a role. Using flexibility and transparency as guiding principles, auditors should develop adjustable channels to stay more closely connected to leadership, with an emphasis on data delivery, stress testing and analysis.
While traditional risks remain, auditors should be ready to quickly change their focus as newer challenges present themselves. Many of the newer risks center on the distributed workplace and how it affects organization and governance.
To be sure, it's a big challenge for IA to keep up with the demands of the moment. But it is also an opportunity, driven by an immediate need, for auditors to engage with other departments on a more integrated level, and to help spread the use of new digital tools, such as data mining and artificial intelligence. These are capabilities that many Agile auditors have in their toolboxes but they are often lacking in the larger organization, so this is an opportunity to socialize the Agile mindset and toolbox while drawing on their benefits.
Even as the COVID-19 crisis continues to rage, auditors need to be thinking about the next step forward, when the marketplace and the economy gradually regain their footing. As we noted in the webinar, the initial shock and awe of the crisis has passed, though much of the economy remains in the response phase. But when the economy begins to move into the recovery phase, Agile auditing needs to refashion itself again.
It is at this point that internal auditors may need to re-think their risk assessment frameworks. For example, in view of the current strain on supply chains, there might be a need to re-assess third-party risk. Auditors might also want to look at other areas that came under stress during the crisis, such as cash management and inventory control, and reassess how they are tracked.
On another level, internal auditing needs to communicate to the organization's leadership how changed business priorities affect the risk profile of the organization as it moves through different phases of the crisis cycle. It is IA's responsibility to evaluate not only the likelihood of new risks during this phase, but to also assess how quickly such challenges may arise and the extent of their duration. Velocity, duration, speed – all this creates new risk dimensions for internal audit to consider and underscores the need for dynamic and iterative approaches as opposed to the linear, predictable audit planning of prior years.
The recovery phase is also an opportune time to ensure that organizations are more resilient to big-impact risks in the future. The leadership may feel, after the uncertainty subsides, that they've weathered the crisis of the century and that it's time to get back to managing more normal risks. But the truth is that black swan events occur much more often than one might think. In the past several years, there have been any number of major crises that had significant, though geographically more limited impact – other viruses and diseases, the Japanese tsunami and the Great Recession of 2008 come to mind. Auditors need to point this out and establish risk frameworks for dealing with such events.
Perhaps the most consequential activity of the post-recovery phase is analyzing and documenting the lessons learned. How well did IA do during the crisis and how might its future role be improved? As with other aspects of Agile auditing, this is best done in an integrated manner, involving as many departments as possible. Doing so creates company-wide acceptance for an Agile internal audit function as it moves the risk management capabilities of the organization forward.
One key area of learning should be how well the company used rapid deployment of cross-functional teams. Such information would enable auditors to establish new models of engaging with stakeholders, reporting findings and compressing the time-to-value period of analyses.
Another key area of analysis should be the use of data and digital tools, as well as the accessibility of leadership to real-time dashboards.
And finally, the post-crisis analysis should focus on the continued introduction of new digital mindsets and technology throughout the organization, including the IA function. As both experts and non-experts have observed, companies that were further along the digital curve tended to be less devastated by the COVID-19 crisis, and even used it as an opportunity to take a clear lead. The crisis and its aftermath are a great opportunity for internal audit to highlight the risk of remaining a digital laggard and move the organizations higher on the digital maturity curve.
Looking ahead, Agile auditing will continue to be the best way forward for IA, as organizations adjust with a changed market and social environment. It will enable auditors to better align assurance with the dynamic condition of a post-COVID world.
Access the free on-demand version of our webinar here.
agile auditing COVID-19 Data and Analytics dynamic risk assessment next gen audit
Norman Marks says:
Thank you for sharing this. Please see how I have extended the points in https://normanmarks.wordpress.com/2020/05/22/should-we-audit-at-the-speed-of-risk/
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Things are heating up for our chapter and for Mars. Orbital Sciences joined the commercial space world with a successful launch this Saturday of their ISS supply spacecraft from Wallops Island, VA. Orbital is a company similar in size to SpaceX, but from a more traditional aerospace contractor mold. This is a reminder that the heart of commercial business is competition! Now is an exciting time for space as it broadens in the number of players and drops in cost, which in turn will be an enabler for future space exploration.
NASA is floating their next 'manned deep space mission that isn't a direct mission to mars' idea, an asteroid roundup. One day, they'll run out of ideas and finally give up and admit Mars is the only logical next objective for human deep space flight. One day.
In local news, we are gearing up for the national convention, Moon Day, the URC, and other activities. We can discuss more about our T-shirt design, and hear more about our local activities.
Mars Society president and aerospace engineer Dr. Robert Zubrin will debate Dr. Phil Cafaro, a professor of Philosophy at Colorado Christian University (CCU) and president of the International Society for Environmental Ethics, who says that we need to stop immigration and impose population control in order to stop global warming. CCU will host the event on Monday, April 15th at 7:00 p.m. in Lakewood, Colorado.
The planned debate, entitled "Are People the Problem?", was occasioned by an article that Dr. Cafaro wrote in the Denver Post, arguing that immigration contributes to global warming, because by coming to America, immigrants increase their incomes, and thus their carbon footprints. This, says Dr. Cafaro, must be stopped.
Dr. Zubrin then published a rebuttal of this argument in National Review.
In addition, Dr. Cafaro requires that the world population be cut down from its current 7 billion to 2 billion, and recommends using the denial of U.S. foreign aid as a method to coerce Third World countries to accept population reduction. In addition, argues Dr. Cafaro in his included essay entitled "Is humanity a cancer upon the Earth?", economic growth must be ended.
In the same book, contributing author David Foreman, the founder of Earth First and fellow leader of the "Apply the Brakes" anti-growth organization, objects to feminist interference in the family planning movement on the grounds that some feminists have the temerity to insist that a woman's right to choose also includes the right to choose to have children. He says they have no such right.
This is going to be a significant debate. Dr. Cafaro's views bring sharply into focus the anti-human and totalitarian implications of the 'Zero Growth' movement. In opposing him, Dr. Zubrin will make the case for human creativity and freedom.
Admission to the debate is free, but advance registration is required. Those wishing to attend may register online.
articles, videos/photos I've come across in the steam.
Thanks Greg. I'll certainly hit 10,000 tweets/re-tweets (mostly about Mars) before July 4th.


These shaft clamping elements are designed to give optimum concentricity, both radically and axially. Similar in design to the RCK 13, but with increased length to provide improved support, and reduced pressures on both shaft and hub. These units must always be installed inside the hub to ensure optimum concentricity. Axial movement of hub will occur during clamping operation.


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Thank you to everyone who took part in NCT Video Event!
We are happy to announce the winners of our event.
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text:
Essay on Management Options in Childhood Cancer
Published: 9th Apr 2021
A 5-year-old girl presents to the GP with signs and symptoms of a non-specific abdominal tumour. The GP refers on for further investigation to establish a diagnosis. She is an only child; the parents are acrimoniously divorced and share custody. Evaluate the management options that will need to be considered and the potential impact upon the wider family.
Paediatric cancer is rare- accounting for only 0.5% of cancers in the UK (Children with Cancer UK, 2018). Signs and symptoms of the more common paediatric cancers can be mistaken for more common illnesses meaning that the early warning signs of the tumour can be missed (Aquilino, 2012). In this essay, I will discuss management options and wider considerations using a scenario of a 5-year-old girl (Patient A) presenting with signs and symptoms that lead to a diagnosis of intermediate risk stage 3 Wilms' tumour (WT) with favourable histology.
According to Children with Cancer UK (2018), WT occur most commonly in children under 5. Typically, the disease is unilateral, but in 5-10% of cases it can present on both kidneys (American Cancer Society, 2018a). There are two different histopathologic types of WT that are recognised: favourable histology, no anaplasia and anaplastic histology, anaplasia present and potentially diffused throughout the tumour. Similarly, anaplastic tumours can be subdivided into focal anaplasia (anaplasia is only present in part of the tumour) and diffuse anaplasia (anaplasia is present throughout the tumour) with the latter of the subdivisions being the more difficult to treat thus affecting the management options available resulting in a poorer prognosis (American Cancer Society, 2018a; Davidoff, 2012).
WT exhibits common symptoms such as a fever or nausea that can be mistaken for a common cold or stomach bug therefore 80% of WT patients present with an abdominal mass (Paulino, 2016). This means it's more likely that when Patient A presented to the GP it was due to an abdominal mass being felt (Aquilino, 2012). During the assessment, the GP will perform a physical examination where the primary abdominal mass will be palpated (Paulino, 2016). Upon confirmation of a palpable abdominal mass, Patient A would be urgently referred for specialist assessment within 48 hours. (National Institute for Health and Care Excellence, 2017)
The initial imaging method used is ultrasound due to its non-ionising properties but magnetic resonance imaging (MRI) and computed tomography (CT) remain necessary in order to gain adequate information for diagnosis and staging (Lopez and Lorenzo, 2017). Coley (2018) argues that children are at a higher risk of radiation-induced carcinogenesis thus measures are in place to reduce these effects including protocols that limit tube current and overlapping of areas being imaged. According to Pao et al. (2015), it is likely that Patient A will have a biopsy along with a catheter placement ready for neo-adjuvant chemotherapy treatment. They argue that despite most patients with WT being cured, there are significant psychosocial challenges throughout the patient's journey, involving both the patient and family. In the scenario given, these issues are slightly more complicated as a multidisciplinary approach to better quality of life will involve the parents which, due to an acrimonious divorce, could prove difficult for Patient A's parents while coming to terms with their child's diagnosis (Pao et al., 2015). Both Pao et al. (2015) and Feinberg (2014) highlight the guilt and blame parents can feel as a result of watching their child go through painful medical procedures. In Patient A's case, the parents share custody thus they may not have discussed little, seemingly unimportant, changes in Patient A- such as being feverish- that indicated early stage WT.
According to the Children's Oncology Group, stage 3 WT means that microscopic or gross residual tumour remains- this could include positive surgery margins, lymph node metastases etc. (Lopez & Lorenzo, 2017). In Patient A's case, she will receive neo-adjuvant chemotherapy prior to surgery to shrink the tumour. Due to Patient A's staging being non-metastatic, this will include a 4-week regime involving Vincristine and Actinomycin D prior to surgery (Cancer Research UK, 2017a; Children's Cancer and Leukaemia Group, 2015). The Children's Cancer and Leukaemia Group (2015) recommend a needle biopsy before any chemotherapy is undertaken to obtain a histological diagnosis. Similarly, Lopez and Lorenzo (2017) note that the Children's Oncology Group advocate surgery as the first treatment option instead of neo-adjuvant chemotherapy as the nephrectomy will provide detailed staging and histology that can better inform post-operative treatment. However, this is only possible for tumours that do not extend past the hepatic vein. Feinberg (2014) refers to this stage as the 'treatment initialisation stage' where the family start to see the realities of their child's diagnosis. Pao et al. (2015) supports this by laying out new concerns for parents. In Patient A's case, her parents' lives will begin to revolve around her treatment. Her parents share custody, and thus would both have to worry about the cost of travelling to treatment, organising their daily lives around travel including absence from work- their acrimonious divorce could complicate this. At this stage, Patient A's treatment will have started to disrupt normal activities. She is 5-years-old so she will either be getting ready for school or have already started therefore a disruption of her education at this age is going to have a significant impact on her grades, future goals and aspirations (Pao et al., 2015).
After neo-adjuvant chemotherapy, Patient A will then undergo a nephrectomy to remove the diseased kidney and the surrounding tissues, including the adrenal gland and lymph nodes (Cancer Research UK, 2017b). At this point in treatment Patient A might already be experiencing side effects due to the toxicities of chemotherapy. Hair loss, nausea and fatigue are common side effects of chemotherapy regardless of age (American Cancer Society, 2018b). However, side effects of chemotherapy can be more severe in paediatric cases like Patient A's due to paediatrics being able to tolerate more intensive treatments (Murusak, 2018). Pao et al. (2015) and Murusak (2018) both discuss the impact of the side effects on the wider family, noting that parents feel more distress throughout treatment as they begin to witness the side effects and invasive nature of treatment. In Patient A's case, it will be particularly distressing for her parents to cope with this as well as watching her undergo a major operation. Mavrides and Pao (2014) identify two different forms of anxiety experienced by children and highlight how they manifest. The two main forms of anxiety that could affect Patient A during her patient journey are anticipatory anxiety and separation anxiety. They theorise that children can become conditioned to a painful procedure, smell, room etc. This means Patient A could have developed anticipatory anxiety in response to previous diagnostic procedures such as her biopsy meaning she could be experiencing higher levels of anxiety about her surgery. Patient A is in the pre-school development age meaning she is likely to be egocentric and family central- being an only child makes this particularly likely. Mavrides and Pao (2014) highlight that separation anxiety is common in the pre-school aged stage of development thus high anxiety levels could make surgery particularly traumatic for Patient A. However, they suggest that this can be prevented by her parents staying nearby. However, this would depend on a resolution between her parents being agreed upon which could prove difficult.
After surgery, radiotherapy is used to kill any remaining cancer cells. Patient A will receive both post-operative chemotherapy and radiotherapy. Adjuvant chemotherapy and radiotherapy has several indications including histology and spread of disease (Cancer Research UK, 2017a). The Royal College of Radiologists (2016) recommend chemotherapy using vincristine, Actinomycin D and doxorubicin after surgery- the duration and number of drugs is dependent on staging. However, Pritchard-Jones et al. (2015) found that the omission of doxorubicin in the post-operative chemotherapy regime had no effect on 5-year survival rate of patients. Alongside chemotherapy, Patient A will receive flank radiotherapy to the tumour; the Royal College of Radiologists (2016) propose different radiotherapy techniques depending on staging. Due to Patient A's tumour being Stage 3 and intermediate risk, her recommended prescription is 14.4Gy in 8 fractions of 1.8Gy daily over 1.5 weeks; if disease is found to be present in Patient A's lymph nodes then a boost prescription of 10.8Gy in 6 fractions of 1.8Gy over 1.5 weeks is recommended. Radiotherapy will cause side effects that Patient A and her parents will have to deal with throughout treatment and later life.
Feinberg (2014) refers to this stage of treatment as the 'illness stabilisation phase' where treatment has become part of the family's everyday life. It is noted by Marcus (2012) that parents of children with cancer are often relatively resilient and alter their roles, responsibilities and family functioning in order to care for their child. By this stage in treatment, it is likely that Patient A's parents have adjusted their daily lives in order to care for her while on treatment. This could include more open communication so that Patient A's side effects can be closely monitored and managed accordingly or being absent from work to attend daily treatments (Pao et al., 2015; Sulkers et al., 2015). Sulkers et al. (2015) highlight that poor family function (including single parents) can lead to increased stress and a difficulty with managing and collecting important information for both parents. They argue that these pressures are due to an associated busy or disorganised family life as separated parents; this can be perceived by the parent as poor social support hence it is likely that both parents are going to feel a high level of stress and anxiety throughout Patient A's journey- from diagnosis to survivorship- due to the unfamiliar and changing parental responsibilities.
The American Cancer Society (2018c) highlights the possible radiotherapy side effects Patient A is likely to experience, including fatigue, diarrhoea and nausea and vomiting. If fatigued, Patient A will still be able to continue some of her normal daily activities, but she may need closer supervision (CureSearch, 2018). Nausea and vomiting are more difficult to manage as persistence of these side effects will involve medication; anti-emetics can be prescribed for nausea and anti-diarrhoeals for diarrhoea (American Cancer Society, 2018d; Cancer Research UK, 2017b). Shared custody means both of her parents will have to inform themselves on the management options and discuss together how best to care for their daughter; this could cause tensions and distress if her parents cannot remain civil under stress.
Mittal and Kent (2017) discuss late effects of treatment and thus define these as toxicities that are not present at the end of treatment but manifest later. Fertility is a major concern in paediatric radiotherapy due to the potential harm on the child at small doses. Patient A is receiving flank radiotherapy so is at risk for these late effects. Mittal and Kent (2017) indicate that flank radiotherapy does not affect the ovaries but can have an underlying impact on foetus size in later life due to effects on the uterine muscle and vasculature. This is something that Patient A and her partner will have to discuss as she approaches the age at which she wishes to start a family. According to Guerreiro et al. (2018), other late effects include increased risk of renal failure and secondary cancer within the radiation field. They argue that children are more at risk of developing radiation induced late-effects (RILE) but the recent advancements in radiotherapy techniques including intensity modulated radiotherapy (IMRT) using MRI-guided delivery techniques lower the dose to surrounding organs. This in turn reduces the risk of RILE. This would be the ideal treatment plan for Patient A as she will already have psychosocial barriers to overcome during the transition into adolescence and secondary cancers will cause further psychological distress including depression and potentially suicidal thoughts (Mavrides & Pao, 2014). This also eliminates further distress for her parents as they won't have to cope with the same anxieties about their child going through cancer treatment again. Therefore, MRI-guided IMRT would be the best approach for Patient A's treatment. However, this is a new technique and healthcare professionals will have to consider the feasibility of this technique for Patient A.
After treatment, the main concern in the family shifts from daily treatment worries to dealing with anxieties of survivorship. Being 5-years-old at the age of diagnosis could have impacted on Patient A's school work, social functioning and separation anxiety; this could make readjusting to normal life difficult (Marusak, 2018). Similarly, anxiety levels can also increase due to a feeling of being alone without the constant contact with healthcare professionals (Feinberg, 2014; Vetsch et al., 2017). Patient A and/or her parents may receive therapy after treatment in order to cope with the difficulties of survivorship. Easing back into normal life could prove difficult for Patient A's parents as they might have psychosocial traumas to deal with alongside helping Patient A adjust to survivorship- this may include home-schooling or dealing with psychological late effects such as social anxiety or depression (Mavrides & Pao, 2014). However, periodic follow-up appointments become the only major responsibilities after treatment thus lessening overall anxiety in the family.
In summary, the treatment of WT can have significant psychosocial impacts on both the patient and the parents. A diagnosis of cancer can cause guilt and anxiety in parents as well as anxiety and impaired development for the child. More support systems need to be in place to help parents cope with the psychological distress of caring for their child with cancer including support long-term post-treatment to help the family cope with survivorship (Sulkers et al., 2015)
American Cancer Society. (2018a). What are wilms' tumors?. American Cancer Society. Retrieved December, 20, 2018 from https://www.cancer.org/cancer/wilms-tumor/about/what-is-wilms-tumor.html
American Cancer Society. (2018b). Chemotherapy for Wilms Tumors. American Cancer Society. Retrieved January, 4, 2018 from https://www.cancer.org/cancer/wilms-tumor/treating/chemotherapy.html
American Cancer Society. (2018c). Radiation Therapy for Wilms Tumors. American Cancer Society. Retrieved January, 4, 2019 from https://www.cancer.org/cancer/wilms-tumor/treating/radiation-therapy.html
American Cancer Society. (2018d). Medicines to prevent and treat nausea and vomiting. American Cancer Society. Retrieved, January, 5, 2019 from https://www.cancer.org/treatment/treatments-and-side-effects/physical-side-effects/nausea-and-vomiting/nausea-and-vomiting-drugs.html
Aquilino, B. (2012). Top 5 pediatric cancers: the warning signs. Roswell Park. Retrieved December, 11, 2018 from https://www.roswellpark.org/cancertalk/201209/top-5-pediatric-cancers-warning-signs
Cancer Research UK. (2017a). Treating wilms' tumour. Cancer Research UK. Retrieved January, 3, 2019 from https://www.cancerresearchuk.org/about-cancer/childrens-cancer/wilms-tumour/treatment
Cancer Research UK. (2017b). Treating diarrhoea. Cancer Research UK. Retrieved January, 4, 2019 from https://www.cancerresearchuk.org/about-cancer/coping/physically/bowel-problems/types/diarrhoea/treating-diarrhoea
Children with Cancer UK. (2018). Childhood cancer facts and figures. Children with Cancer UK. Retrieved December, 17, 2018 from https://www.childrenwithcancer.org.uk/childhood-cancer-info/childhood-cancer-facts-figures/
Children's Cancer and Leukaemia Group. (2015). Clinical management guidelines Wilms tumour. Leicester: CCLG
Coley, B. D. (2018). Paediatric diagnostic imaging (13th Ed.). [e-book]. ISBN: 9780323497480
CureSearch. (2018). Radiation therapy in children. CureSearch. Retrieved January, 5, 2019 from https://curesearch.org/Radiation-Therapy-in-Children
Davidoff, A. M. (2012). Wilms tumor. Advances in Paediatrics, 59(1), 247-267. doi: 10.1016/j.yapd.2012.04.001.
Feinberg, T. H. (2014). The impact of childhood cancer on family functioning: a review, Graduate Student Journal of Psychology, 15(1), 18-30. Retrieved from https://www.tc.columbia.edu/publications/gsjp/gsjp-volumes-archive/
Guerreiro, F., Seravalli, E., Janssens, G. O., van den Heuvel-Eibrink, M. M., W Lagendijk, J. J. & Raaymakers, B. W. (2018). Potential benefit of MRI-guided IMRT for flank irradiation in pediatric patients with Wilms' tumor. Acta Oncologica. Advance Online Publication. doi: 10.1080/0284186X.2018.1537507
Lopez, R. I. & Lorenzo, A. (2017). Recent advances in the management of Wilms' tumor, F1000 Research, 6(1), 670. doi: 10.12688/f1000research.10760.1
Marcus, J. (2012). Psychosocial issues in pediatric oncology. The Ochsner Journal, 12(3), 211-215. ISSN: 1524-5012
Marusak, H. (2018). Understanding the Psychological Effects of Childhood Cancer. Scientific American. Retrieved December, 8, 2018 from https://www.scientificamerican.com/article/understanding-the-psychological-effects-of-childhood-cancer1/
Mavrides, N & Pao, M. (2014) Updates in Pediatric Psycho-Oncology. International Review of Social Psychology, 26(1), 63-73. doi: 10.3109/09540261.2013.870537
Mittal, N. & Kent, P. (2017). Long-Term Survivors of Childhood Cancer: The Late Effects of Therapy. In Wonders, K. (Ed.), Pediatric Cancer Survivors [e-book]. doi: 10.5772/63327
National Institute for Health and Care Excellence. (2017). Suspected cancer: recognition and referral. NICE. Retrieved December, 20, 2018 from https://www.nice.org.uk/guidance/ng12/chapter/1-recommendations-organised-by-site-of-cancer#childhood-cancers
Pao, M., Kazak, A. E., Wiener, L. S., Patenaude, A. F., Kupst, M. J. & Arceci, R. J. (2015). Pediatric psycho-oncology: a quick reference on the psychosocial dimensions of cancer symptom management. [e-book]. ISBN: 0199335117
Paulino, A. C. (2016). Wilms tumor clinical presentation. Medscape. Retrieved January, 3, 2019 from https://emedicine.medscape.com/article/989398-clinical
Pritchard-Jones, K., Bergeron, C., Camargo, C., Mvan den Heuvel-Eibrink, M., Acha, T., Godzinski, J., … Graf, N. (2015). Omission of doxorubicin from the treatment of stage ii–iii, intermediate-risk wilms' tumour (siop wt 2001): an open-label, non-inferiority, randomised controlled trial. The Lancet, 386(9999), 1156-1164. doi: 10.1016/S0140-6736(14)62395-3
Sulkers, E., Tissing, W. J. E., Brinksma, A., Roodbol, P. F., Kamps, W. A., Stewart, R. E., … Fleer, J. (2015). Providing care to a child with cancer: a longitudinal study on the course, predictors, and impact of caregiving stress during the first year after diagnosis. Psycho-oncology, 24(3), 318-324. doi: 10.1002/pon.3652
The Royal Collage of Radiologists. (2016). Radiotherapy dose fractionation. London: The Royal College of Radiologists
Vetsch, J., Fardell, J. E., Wakefield, C. E., Signorelli, C., Michel, G., McLoone, J. K., … Cohn, R. J. (2017). "Forewarned and forearmed": long-term childhood cancer survivors' and parents' information needs and implications for survivorship models of care. Parent Education and Counseling, 100(2), 355-363. doi: 10.1016/j.pec.2016.09.013
Business Bliss Consultants FZE. (November 2018). Essay on Management Options in Childhood Cancer . Retrieved from https://nursinganswers.net/essays/essay-on-management-options-in-childhood-cancer.php?vref=1
"Essay on Management Options in Childhood Cancer ." nursinganswers.net. 11 2018. Business Bliss Consultants FZE. 01 2023 <https://nursinganswers.net/essays/essay-on-management-options-in-childhood-cancer.php?vref=1>.
"Essay on Management Options in Childhood Cancer ." Business Bliss Consultants FZE. nursinganswers.net, November 2018. Web. 31 January 2023. <https://nursinganswers.net/essays/essay-on-management-options-in-childhood-cancer.php?vref=1>.
NursingAnswers.net. November 2018. Essay on Management Options in Childhood Cancer . [online]. Available from: https://nursinganswers.net/essays/essay-on-management-options-in-childhood-cancer.php?vref=1 [Accessed 31 January 2023].
Business Bliss Consultants FZE. Essay on Management Options in Childhood Cancer [Internet]. November 2018. [Accessed 31 January 2023]; Available from: https://nursinganswers.net/essays/essay-on-management-options-in-childhood-cancer.php?vref=1.
{{cite web|last=Answers |first=All |url=https://nursinganswers.net/essays/essay-on-management-options-in-childhood-cancer.php?vref=1 |title=Essay on Management Options in Childhood Cancer |publisher=business-bliss.com |date=November 2018 |accessdate=31 January 2023 |location=Fujairah, UAE}}
Business Bliss Consultants FZE, 'Essay on Management Options in Childhood Cancer ' (nursinganswers.net, January 2023) <https://nursinganswers.net/essays/essay-on-management-options-in-childhood-cancer.php?vref=1> accessed 31 January 2023


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Quentin Tarantino's first script that he wrote turned out to be one he couldn't get made himself. Lucky for us (or unlucky as some Tarantino fans feel), he managed to get "True Romance" into the hands of Tony Scott. Tony gave it a linear structure and a happy ending and, in our estimation, created a magical fairy tale of a film. We're continuing our "Couples on the Run" series and are thrilled with this week's edition of "True Romance" to the list. Join us — Pete Wright and Andy Nelson — as we talk about the origins of the script and its road to becoming the film that it is. We chat about not only the incredible performances throughout the film, but also the amazing, star-studded line-up of actors playing the parts and how much we enjoy them all. We discuss the nature of the violence in the film and how it created quite a stir politically at the time though how, by today's standards, it's not too harsh. And we hit on the crazy Tarantino Universe theory and how this film ties into it. We love this film and have a great time talking about it. Tune in!


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redpajama_set_name: RedPajamaGithub


text:
Q: Strange error on IIS when server is busy On windows 2008/IIS a asp.net page with heavy processing gets called every hour.  If that server is doing nothing else it's fine.  If the server is handling other web requests at the same time we get this error occasionly:
.NET Runtime version 2.0.50727.4016 - Fatal Execution Engine Error (000007FEF630A5C6) (80131506)

and
Faulting application w3wp.exe, version 7.0.6002.18005, time stamp 0x49e03238, faulting module mscorwks.dll, version 2.0.50727.4016, time stamp 0x49cc56fb, exception code 0xc0000005, fault offset 0x000000000019734e, process id 0x%9, application start time 0x%10.

And then iis dies and restarts.  How can I get more information about what's causing this error and how to fix it?

A: According to Tess Ferrandez:

Fatal Execution Engine Exceptions
Fatal Execution Engine Exceptions are fairly rare, but when they occurr it's normally a bug.  This means that for some reason we went into some piece of code that we were not supposed to in the CLR and the CLR has decided that in the unlikely event that someone comes in here, let's throw a Fatal Execution Engine exception and die because we can't recover from this point. In the eventlog this will be logged as Execution Engine Exception occurred and the address listed will tell exactly where in the code it occurred.  If you reach one of these and can't find a knowledge base article about it, contact support, preferably with a crash dump available since that will speed up the time to resolve the case tremendously.

She also has lots of information on her blog about generating crash dumps, etc, etc for debugging purposes.

A: That's likely not an easy error to track down.  Some places that I should looking are:

*

*IIS logs, see if you can tell what happened just prior to the issue

*Event Viewer, it's possible that it's a hardware issue and you've touched on bad memory

*Hardware vendor's hardware logs

*Turn on Failed Request Tracing and see what's logged just before the error

*See if you can catch the error with Debug Diag and get a dump as the issue occurs

A: Have you tried to run your application with other .NET Framework version installed on server?
If .NET Runtime version 2.0.50727.4016 is important for you - may be this KB article (and patch availible) will help you...

A: Microsoft say it's this issue:
http://support.microsoft.com/kb/974168
They have given me a fix.  I haven't tried it yet but I will soon...

redpajama_set_name: RedPajamaStackExchange


text:
Greek Jewish community holds protest after desecration of cemetery
The desecrated Jewish cemetery in Athens. (Social media)
(Social media)
WhatsApp Email https://worldisraelnews.com/greek-jewish-community-holds-protest-desecration-cemetery/
The Jewish community of Athens formed a living human circle around the Jewish cemetery in a silent protest against anti-Semitism.
By: Yossi Lempkowicz/JNS and World Israel News Staff
The Jewish community of Athens on Sunday formed a human circle around the Jewish cemetery of the city in a silent protest to say that anti-Semitism will not be tolerated in Greece. The cemetery was desecrated last week.
The protest rally was called by the Central Board of Jewish Communities in Greece (KIS), which represents the country's 6,000 Jews,
Members of the Greek government and religious groups participated in the rally in a gesture of solidarity with the Jewish community.
The vice mayor of Athens, Lefteris Papagiannakis, addressed the rally.
The World Jewish Congress (WJC) stated that it stands with the Jewish Community of Athens in condemning repeated anti-Semitic attacks and its initiative to organize the protest. The group has launched a social-media campaign to raise awareness of the anti-Semitic manifestations ongoing in Greece, urging people worldwide to join in support.
"The World Jewish Congress abhors the despicable and cowardly act of desecrating Jewish property and stands firmly with the local Jewish community in urging individuals, organizations, and public authorities to mobilize in any way possible to make it absolutely clear that there is no room for anti-Semitism in Greek society," said WJC CEO Robert Singer. "It is inconceivable that still today, anti-Semitic stereotypes are rife in Greece. We cannot stand by in silence as hatred continues unhindered."
Read Anglican Church condemns desecration of Protestant cemetery in Jerusalem
"Greece was once home to a strong and influential Jewish community, which was all but decimated during the Holocaust. The community that remains today is small but still vibrant, and unfortunately is no stranger to anti-Semitic manifestations. We thank Athens Mayor Giorgis Kaminis for publicly condemning this anti-Semitic act, and urge other politicians and authorities to follow suit," he added.
Most of Greece's pre-war Jewish population was deported and murdered in Nazi death camps by German occupation forces toward the end of the war.
Vandalism of Jewish sites and anti-Semitic attacks has increased in Greece since the rise in recent years of the Nazi-inspired Golden Dawn party, which grew to become Greece's third-largest political party.
Among Europeans, Greeks have some of the most negative attitudes towards Jews, a 2016 Pew Research Center study revealed.
anti-SemitismCemetery desecrationGreece
I found a very interesting article on World Israel News! Click to read this: --> https://worldisraelnews.com/greek-jewish-community-holds-protest-desecration-cemetery/


It's that time of day – the start.
Arguably the hardest part of the day because this is the pivotal point where you can choose to either stay warm, snuggled underneath the covers, blissfully ignorant of the world around you, or you can fling back the bedding and expose yourself to what the day has in store for you.
Unless you've built enough wealth to the point where getting out of bed doesn't equate to being able to eat and pay rent, you probably make it out of bed one way or another. Sigh.
For some people, starting the day is an easy task – even an enjoyable situation. For others, it takes great mental fortitude.
Maybe there's a huge deadline looming at the end of the day that will most likely equate to late hours; or maybe you're having relatives over and need to clean, prep, cook, and entertain them afterwards; or maybe you've had an awful week and those emotions are still weighing on you… Most of us have incredibly busy schedules, to the point where if we stop to think, our days become a mountain of seemingly insurmountable tasks. It's overwhelming. Trust me, I've been there.
What often happens is that instead of buckling down and getting the job done, we find something else to do to avoid the tasks we don't want to focus on, even though we know they need to get done. Generally they're still tasks that are on your list, but in the back of your mind, the elephant is still in the room.
So, what to do when you're in this situation?
Let's rewind to the start of the day.
After you get up in the morning you generally follow some sort of routine. For my typical morning routine, the first thing on my mind after I get out of bed is to take a trip to the loo (nature calls) and splash some water on my face, then eat breakfast, get dressed (sometimes it's only glorified PJs), and put some makeup on (if someone other than my husband will see me that day). Then I'd jump right into work. As the day wore on, I started to feel more like Hermione Granger's hair in her younger years. Frazzled. Harried. All over the place. And never feeling like I was getting anywhere with my work.
My husband was in the same boat. We decided we didn't want our lives to feel this way anymore.
This was a turning point in our lives and where I'll introduce the term, mise en place.
Mise en place means "everything in its place." This is a culinary term I learned from Dominique Ansel while watching his French pastry class on MasterClass. The basic concept is to prepare everything before even beginning – ingredients, equipment, and workstation.
By doing so, a chef fluidly moves through the recipe and achieves excellent, consistent results. Mise en place doesn't only refer to the prep, but the whole cooking process, including clean–up. Everything goes back to its home once it is no longer needed. Chef Sebastien Rouxel equates this to his success in his book, Bouchon Bakery. It becomes a mindset – one that Marie Kondo would approve of.
It's an act of mindful concentration and organization.
In the simplest terms, it's making a plan.
The result? Setting yourself up to successfully execute an action.
Take at least 10 minutes (and yes, that may mean resetting your alarm clock) to calmly identify and organize the most important activities of the day.
Though you could translate your plan physically, such as blocking out your calendar, making a checklist, or setting your clothes out the night before – the important part is that you have it sorted out mentally before you start your day. For example, my husband and I go on morning nature walks to mentally prepare for our work day.
It helps to have a specific place to get into the meez mindset – one that you find refreshing. Perhaps it's having a good cup of coffee in your favorite chair while sketching out the day, going somewhere with a good view, or simply laying in bed and enjoying a few blissful moments of quiet before jumping into the day. Whatever special place you find, make sure it allows the mental space to organize your thoughts.
If you read my preceding blog, Finding Reality in Your Expectations, you might think it contradicts the main concept of this one. However, the idea isn't to create a plan and then toss it to the wind.
The beauty of the meez mindset is that it equips you to be prepared for the day, so that in case things do get crazy, you have the mental fortitude to be able to handle it. It's an exercise that lets you reset and refocus on the task ahead of you. By the end of the day, you can reflect and adjust for the next day as needed.
If you find yourself getting increasingly stressed during the day, take a moment to reset and re-prioritize.
Are you willing to try the meez mindset today?
In this monthly series, we'll be exploring work/life balance and some hands-on ways to tackle it. Because let's face it, life is always busy.
Disclosure: We provide professional reviews that receive compensation from companies whose products we review. We test each product thoroughly and give high marks only to those we personally believe in. We are independently owned and the opinions expressed here are our own.


This cute boot topper is knit on the All In One loom using a worsted weight yarn. You could also knit these on the Martha Stewart loom as well. Instructions for configuring the Martha Stewart loom are included in the pattern.
You can knit it all one color, or switch colors mid-way to have two different boot toppers in one!
If you know how to e-wrap knit and how to purl, you can work this easy pattern up in one or two evenings.


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London Pattern Trowels are designed for laying brick. Rounded heel shapes the blade so that the mort..
Made from imported Jarrah hardwood, which is harder than teak * Outlasts several ordinary wood float..
Made from straight grain mahogany, a unique two-way tapered blade. Darbies are longer versions of ha..
Made of blue steel. •90º blade angle. •Resilient DuraSoft® handle provides a soft feel, reduces fati..
Rugged aluminum casting. Designed specifically to connect standard threaded handle sections to a fre..
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Made of 301 premium stainless steel. •Resilient DuraSoft® handle provides a soft feel, reduces fatig..


San Diego (June 25, 2007) --- San Diego, California based architect Kevin deFreitas has teamed up with Kyocera Solar, Inc. to build the San Diego Home & Garden Energy Efficient Innovation Home, the first residential home seeking to qualify for LEED certification in the San Diego area. The single family residence will incorporate a Kyocera solar electric system, among other state-of-the-art energy efficiency and green building technologies. The home will serve as a demonstration site to educate the public, designers and construction professionals on new energy efficient and green building products.
Casa Futura, as the demonstration home will be called, is currently under construction and slated to be highlighted as the San Diego Home & Garden Energy Efficient Innovation Home in the October issue of the magazine. Home tours are scheduled to take place October 11-28thand will be open to the general public.
Once complete, Casa Futura will feature a Kyocera 4.8 kilowatt solar electric system composed of 24 Kyocera KC200GT modules. REC Solar, a solar electric system installer specializing in grid-tie solar electric design and installation, will install the roof mounted system which is expected to produce roughly 7,200 kilowatt hours of electricity annually.
Kyocera Corporation (NYSE: KYO / http://www.kyocera.com), the parent and global headquarters of the Kyocera Group, was founded in 1959 as a producer of advanced ceramics. By combining these engineered materials with metals and plastics, and integrating them with other technologies, Kyocera Corporation has become a leading supplier of solar energy systems, telecommunications equipment, semiconductor packages, electronic components, laser printers, copiers and industrial ceramics. During the year ended March 31, 2007, the company's net sales totaled 1.28 trillion yen (approximately $10.8 billion).


Private & public life are subject to the same rules, & truth & manliness are two qualities that will Cary you through this world, much better than policy, or tact, or expediency or any other end that was ever divided to Conceal or mystify a devised from a straight line.
Wherever property, talent & virtue are all on one side, & only ignorant numbers, with a mere sprinkling of property & talent to agitate them & make use of them, or misenformed or mistaken virtue to sanction them on the other side, no honest man can take long to deliberate which side he will chose.
Politicians are more or less so warped by party feeling, by selfishness, or prejudices, that their minds are not altogether truly balanced. They are the most difficult to cure of all insane people, politics having so much excitement in them.


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Arnold blasts away in one of five new Terminator: Genisys character posters
Apr 29, 2019, 6:29 AM EDT (Updated)
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Tag: Arnold Schwarzenegger
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Tag: Emilia Clarke
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Tag: Terminator Genisys
Paramount has released some new character posters for Terminator: Genisys, set to open in theaters in just a few weeks.
The five new posters feature Arnold "I'll be back" Schwarzenegger, Emilia Clarke, Jason Clarke, Byung-hun Lee and Jai Courtney. The posters are cool, if a tad generic, but it's intriguing to see Jason Clarke being referred to as the T-3000, instead of John Connor (even if that massive plot twist was actually revealed in the second trailer). The movie will also star Courtney B. Vance and J.K. Simmons, but they are not featured in the posters. Neither is Matt Smith, who's been pretty much MIA from every piece of Terminator promo stuff that's been coming out of Paramount.
When John Connor (Jason Clarke), leader of the human resistance, sends Sgt. Kyle Reese (Jai Courtney) back to 1984 to protect Sarah Connor (Emilia Clarke) and safeguard the future, an unexpected turn of events creates a fractured timeline. Now, Sgt. Reese finds himself in a new and unfamiliar version of the past, where he is faced with unlikely allies, including the Guardian (Arnold Schwarzenegger), dangerous new enemies, and an unexpected new mission: To reset the future…
More Arnold Schwarzenegger
Every Arnold Schwarzenegger sci-fi movie, ranked from worst to best
Chosen One of the Day: The glistening, epic handshake from Predator (1987)
Directed by Alan Taylor, Terminator: Genisys is set to hit theaters on July 1, 2015. Are you ready to reset the future?
(via Comic Book Movie)
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I can't emphasize enough on Pressure+Tilt. The minute change in your hand movement should translate to the marks you are making.
Recently there are more tablet makers releasing models that support pen tilt sensing. One of them is Huion.
I am too used to Wacom's pressure profile. A Wacom stylus requires significantly more force to reach the max pressure value in comparison to the Huion. Right now Expresii is more tuned for Wacom's pressure response so it's a bit hard to control the height of the virtual brush to do calligraphy with the Huion. It could be a personal preference, but so far even after adjusting the pressure curve in both Huion's tool and also in Expresii (yes, internally we do have it), I was still not able to write as well as I can with a Wacom. I'd try to adapt the pressure curve and see if helps. I also hope Huion can adjust the spring in their stylus so that it can better mimic a brush. I'm glad that they would invite me to their Shenzhen Headquarters. I haven't met them yet and I look forward to a fruitful discussion.
I think Huion's stylus sensing technology is really close to that of Wacom. Huion's tilt reading is as stable as Wacom's, and I'm glad to see tilt reading is also available while hovering, just like a Wacom (note that Surface Pen and Apple Pencil won't give tilt reading during hovering). Previously, the main advantage of Wacom is its ability to sense pen tilt+twist (i.e. 6 DOF totally). No other stylus makers can sense pen twist just yet, so Wacom still have some technical advantage. I have always been eager to tell Wacom what to improve in their technology and I did tell them last time I was at Connected Ink. However, I'm not sure if they would do anything about what I said.
I look forward to testing Huion's new Pen Display featuring tilt sensing such as the US$400 Kamvas Pro 13.
In conclusion, I think the Huion has made signification improvement (last time I tried it wasn't that great) and is now a company that can rival Wacom. This would be good for the consumers as they now have more choices that are budget-friendly. I hope Wacom can up their game by developing new technology for brush sensing. I am of course always ready to offer my opinions on how things can be improved.
We thank Huion Hong Kong for providing the hardware and Huion Taiwan for connection.
It was great to be back to Japan, a country that gives so much respect to culture and technology! After taking part in Wacom Connected Ink 2018, we moved on to the show at SIGGRAPH ASIA 2018 in the same metropolis of Tokyo.
Visitors who tried our app immediately noticed that our water-based paint simulation is the best in the world, beating even big players like Corel, Adobe or Autodesk. We also demo'ed our new feature for creating ambigrams. We hope to make it easier to design ambigrams with East Asian characters. We showed ambigram designs printed on art paper and engraved on seals. Our work is certainly aligned with SIGGRAPH ASIA's theme of art, culture and tech crossover. Everyone knowing kanji (Chinese characters 漢字) were amazed by our ambigrams as crossover of calligraphy and design.
We thank the organizer of SIGGRAPH ASIA, led by Chair Ken Anjyo, for putting together such a nice show, and also our fellow exhibitors who put so much effort and energy into the show.
Thanks to Mark Lam of CGVisual.com for letting us demo in their booth, Man Tam of VTech for helping out, and Angela Wong, Rebecca Catquu, and Anita So of Rooftop Animation for helping with the booth.
As Wacom's software partner, we were demo'ing Expresii in Wacom Connected Ink 2018 held on Nov 30 in Tokyo.
In the end of the video above, we also show sample Ambigram artwork done with Expresii.
Wacom is advocating digital stationary and marriage of Analog and Digital. We are definitely on the same page, since we paint with digital tools and simulation, and then gets the result back to the analog world.
We thank Wacom for holding this special event for supporting digital ink and facilitating partnership. We are staying in Tokyo for SIGGRAPH ASIA. Stay tuned for more coverage.
In the West, ambigrams were made popular by Dan Brown incorporating John Langdon's ambigram designs into the plot of his year-2000 novel bestseller Angels & Demons. In around 2013, Japanese artist Issei Nomura (野村一晟) was inspired by Angel & Demons to dive into ambigram design with Eastern characters, which in turn made ambigram with Chinese characters (kanji) popular in East Asia after media coverage from Japan, Taiwan, China & Hong Kong in 2017.
Signature of Bada Shanren might be the earliest ambigram.
In the West, calligraphy is done with pens so strokes are of sharp lines and curves. In the East, brushes are used instead for calligraphy. I believe writing/lining instruments such as pen and brushes have great influence on artistic styles. So far, most of ambigram designs are done with lines and curves, even for Eastern characters (like shown on the right). Today, a typical ambigram design process is to first draft the design on paper, which requires repeated flipping the paper manually. The author would then make the final design on a computer using vector graphics editor programs. This manual paper flipping could impede the workflow, and sometimes it's not easy to do tricky mapping on paper.
With new feature of 'Quarter Mode' in Expresii, we make it easy to create ambigrams directly on a computer, as you can make strokes on one of the quarters and be able to see the result in other quarters immediately.
We demo with the Chinese characters for Yin (陰) and Yang (陰). Yin-Yang is a popular subject for ambigram previously done several times by Japanese authors (see works done in 2009: 回文ユンブイカ, unknown author; 2010: oyadge01, oyadge01×意瞑字査印; 2013: Issie Nomura, 2014: 意瞑字査印; 2015: 意瞑字査印, Satoshi Ito; 2018: Satoshi Ito, ARTAKANA). In fact, the famous Yin-Yang symbol ☯ inspired John Langdon to do ambigrams back in the 70's.
We hope to contribute to the development of our culture by introducing new tool for designing ambigram. In particular, since Eastern calligraphy has been done with a brush for thousands of years, we would like to make it easy to do ambigrams with authentic brush strokes. We hope you like our new feature and would love to hear your feedback!
Expresii is coming to Tokyo!
Register free for Connected Ink here.
Get a free Visitor Pass (includes Exhibition where we'll be demo'ing) for SIGGRAPH ASIA by registering now.
We also express our graitude to CGVisual.com for inviting us to demo again at SIGGRAPH ASIA. Check out our previous reports on SIGGRAPH ASIA 2016 & SIGGRAPH ASIA 2013!
We will now (v.2018-09-16) gradually rolling out high-DPI support that some of you are asking for (by giving bad review). Here, I'd like to say that High-DPI support not a simple easy-peasy toggle of a switch (if it were, Adobe would have had high-DPI Photoshop early on). We do rely on others' UI framework. When such framework doesn't work as expected, we need to look for workaround. Not all software developers are as big as Adobe where you can have a whole arm of developers to work on it. So, please be more understanding and don't give the lowest review score in MS App Store simply because we don't have high-DPI support earlier. Without high-DPI, Expresii is still functional and gives you the world's most organic digital watercolor. Like some of the users say, Expresii deserves the credit. So, please leave a balanced review if you are to leave one.
Blurry rendering using 1/4 the resolution (1/2 width & 1/2 height) and then scaled back up.
FYI, my 2017 Surface Pro with Iris 640 dropped from 100+ to 60-80 FPS switching to high-DPI, depending on the zoom level. So, depending on your GPU, using high-DPI support may or may not be your better choice. FYI, we just got a user reporting that he's very happy with high-DPI on his Surface Studio that still gives 90-150 FPS after the switch.
So, if you find painting is too slow, we recommend using 'System Enhanced' so that it's not slowed down and that you still get some of the texts scaled sharp.
The high-DPI support is not perfect yet. We'll keep working on it.


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Home Topics Cancer RXi Restructures to Focus on Cancer and Spins Out RNAi Therapeutics
RXi Restructures to Focus on Cancer and Spins Out RNAi Therapeutics
Institutional investors purchase $2.5 million worth of new cancer entity common stock and an 83% stake in spin-out.
RXi Therapeutics is restructuring and splitting into two public traded companies with the help of $12 million in investments by institutional players. The newly formed parent company, Galena Biopharma, will focus on the development of targeted cancer therapies,including existing lead Phase III-ready anticancer compound NeuVax (E75 peptide vaccine with GM-CSF adjuvant) and folate binding protein-E39.
RXi Pharmaceuticals, currently a wholly owned subsidiary of Galena, will be spun out later this year, to focus on development of RNAi-based therapeutics. Its main focus will be on moving lead antiscarring/antifibrosis product RXI-109 into the clinic in 2012.
As part of the transactions institutional investors have agreed to invest $9.5 million in RXi preferred stock and $2.5 million in Galena common stock. The RXi preferred stock will be convertible into 83% of the equity of RXi as part of the spin-off. Galena says it expects about another 8% of RXi equity will be distributed on a share-for-share basis such that a holder of one share of Galena common stock prior to the distribution will get one share of Rxi and one share of Galena after the spin-out. Galena will then retain a 4% equity stake in RXi, and RXi's key licensor Advirna will acquire the remaining 5% in equity.
Galena president and CEO Mark Ahn, Ph.D., will serve on the board of RXi. Anastasia Khvorova, Ph.D., will serve as RXi's svp and CSO. Pamela Pavco, Ph.D., has been appointed RXi's svp for pharmaceutical development. RXi's CEO has yet to be appointed.
NeuVax is a cancer immunotherapy targeted for low-to-intermediate Her2-expressing breast cancer patients not eligible for therapy with Herceptin®. Galena expects to start in a Phase III study, Present (prevention of recurrence in early-stage, node-positive breast cancer with low to intermediate Her2 expression with NeuVax treatment), during the first half of 2012.
Folate binding protein-E39 is a targeted vaccine for the treatment of gynecological cancers. It was licensed last week from the University of Texas MD Anderson Cancer Center and Henry M. Jackson Foundation for the Advancement of Military Medicine. The vaccine is expected to start in Phase I/II studies by the end of 2011.
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Advancing mRNA Therapeutics with Engineered Enzymes
StockWatch: Novavax Sinks with Revenue Forecast, Vaccine Demand
BMS, Five Prime Plan Cancer Combo Trial, in $30M+ Expansion of...


Tomaras Lawyers specialises in advising Greek, Chinese, Singaporean and Philippine enterprises and individuals seeking to invest in Australia. Our clients are mainly active investors who wish to acquire either trading businesses which they intend to manage and operate or to acquire commercial real estate for the purpose of managing and operating a business.
Tomaras Lawyers assists its clients, where appropriate, with foreign investment approval applications and liaises with the Foreign Investment Review Board (FIRB) on the client's behalf.


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Engineering tuition may rise to improve school's rankings
Kayla Jonsson
Tuition may increase by 5 percent for engineering students in the 2012-13 school year if a proposal by the Tuition Policy Advisory Committee passes in March, said the dean of the Cockrell School of Engineering.
The increase is a last resort to the school's budget after it was cut by 17 percent in all areas except faculty salary, said Gregory Fenves, dean of the engineering college.
"Any further cuts will be more like an amputation so that's not an option without hurting the value of the engineer's degree," said Fenves Wednesday night at the school's College Tuition and Budget Advisory Committee student forum.
He said the increases to the budget would still be small compared to those of other state universities.
"I know tuition increases are hard for families, but look at what's going on around the country," Fenves said. "Some states have 10 percent increases. We have been planning for this for three years, and we will keep the increase modest."
He said a downgrade in the ranking of many fields within the college for 2012 is a motivation for the change in budget.
"Many rankings dropped drastically, and this is unusual," Fenves said. "I believe word is being spread that the budget has been bad for our programs, so we need a plan so this does not become a reality."
Only 30 percent of engineering freshmen graduate in four years and 50 percent graduate in six years, Fenves said. This is lower than other schools and a high student-to-faculty ratio is the main source of the problem, he said.
"Our student-to-faculty ratio is off the charts," he said. "Our goal is to hire four new professors every year. This will ensure smaller, more comfortable classes as well as more accessible instructors and keep UT competitive."
Fenves said if ranks continue to fall, professors will be tempted to leave UT for higher ranking universities and further heighten the issue.
"Our faculty is very intelligent, and we don't want to lose them to other colleges," he said. "We need to keep our faculty here by having a competitive environment."
Mechanical engineering junior Zachary Wilhoit said he was open to the idea of paying a bit more for tuition if it meant he would receive a high quality education.
"While I know raising tuition isn't very popular, I think you have made a very compelling argument," Wilhoit said. "I came to a great engineering school, and I want to graduate from a great engineering school, and if this is what it takes, I'm all for it."
Fenves' argument that more faculty is needed was also met with support by electrical engineering junior Vik Parthiban.
"I really agree we should hire more professors," Parthiban said. "That would help a lot."


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Here are all of the Google Pixel 3 and 3 XL's current issues
By Dean Daley@deancwdaley
Google's latest smartphones, the Pixel 3 and Pixel 3 XL, are the talk of the town.
The phones offer flagship level specs with the promise of timely and frequent software updates. However, even in all of their greatness, many are reporting various problems with the two handsets.
We will continue to update this post when more issues arise and when Google confirms that fixes are on their way.
Buzzing sound
One of the first widely reported issues to affect the Pixel 3 XL is a buzzing sound that emits from the phone's bottom speaker. Notification sounds and music trigger the issue.
Google announced that it's working on a fix for the issue.
For more on the issue, click here.
According to reports from Android Police, the December security patch has fixed the buzzing sound issue or at least reduced it.
Overheating issue
Some users have reported that when charging their device or making a video call the smartphone gets really hot. Users report that they receive a notification stating that their handsets are overheating, while others indicate the phone just shuts off by itself.
Google is sort of working on a fix. In a comment to MobileSyrup, Google stated, "Like many phones, Pixel is designed to turn off once it reaches a certain temperature. For Pixel 3, you can find more about our safety compliance here. In addition, we are always looking for ways to improve phone performance to mitigate conditions that result in higher temperatures."
For more on the overheating issue, click here.
Screen flickering issue
Users on Reddit have voiced complaints regarding the Pixel 3's flickering screen. The flickering issue causes areas of the phone's display to brightly light up while other portions remain dark.
Some users suggested that the flickering problem is caused by the phone's ambient display functionality.
For more on the screen flickering concern, click here.
Text messages disappearing
Some users claim that complete conversations and group chats will disappear from their Messaging app. The issue only happens on the Pixel 3 handsets, so it became evident that the bug was phone-based and not due to an issue with the app.
Google recently told Gizmodo that a fix for the problem is coming soon.
For more on the disappearing text messages, click here.
Double notches
There's also an amusing issue that can cause a side notch to appear on the Google Pixel 3 XL. In my experience, this issue will persist for about 30 seconds at most and then disappears by itself. However, other users say that they've seen their phone's second notch stay until they restart their phone.
Google confirmed that a fix coming soon.
For more on the double notch issue, click here.
Memory Issue
Lastly, there's also memory management issue with the Pixel 3 and 3 XL. The problem is caused by the device's internal RAM. With the Pixel 3, the device is only able to jump between a couple of apps at a time before it begins to automatically close apps.
Google says a fix is coming in the next few weeks. In its statement, the company said that the update would prevent background apps from closing too early in "certain situations."
For more on the internal memory issue, click here.
Update: Google released a fix for this issue with the December security update. The listing indicated "improved memory performance in certain circumstances."
Camera "encountered a fatal error"
Pixel 3 users have reported experiencing an issue that causes the camera to have pop up saying "fatal error."
Google is reportedly working on the fix but it has yet to roll out.
Google Canada discounts Pixel 3 and 3 XL by $250 for Father's Day
Google Canada once again drops price of Pixel 3 and 3 XL by $250
Telus discounts third-gen Google Pixel by up to $300, includes free Home Mini


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Paytm's Parent To Spin Off Ecommerce Business, Incorporates Paytm E-Commerce Pvt. Ltd.
Ambika Chopra
24 Aug'16 2 min read
One97 Communications Ltd, which runs Paytm, will separate its ecommerce business as its key investor, Alibaba plans to enter India either independently or through an acquisition.
One97 has already created a new company called Paytm E-Commerce Pvt. Ltd, to which it will transfer the online retail business of the payments and ecommerce platform, sources close to the development said.
Once completed, the restructuring will allow Paytm E-Commerce to independently raise money from investors.
"Paytm has already started talking to existing investors, including Alibaba Group, to infuse fresh capital in the new entity," a source said.
According to the documents filed with the Registrar of Companies, The new entity was incorporated on 1August 16, 2016 and currently lists One97 founder Vijay Shekhar Sharma as the majority shareholder in the firm.
Vijay Shekhar Sharma, founder, Paytm said, "Payments and ecommerce have different growth cycles and we believe the ecommerce business can be a sizeable opportunity going forward."
At present, Alibaba has a sourcing business in India and does not sell anything directly to customers. It holds a 40% stake in Paytm and 5% stake in Snapdeal. And if the Chinese ecommerce firm enters India in tie-ups with such ecommerce companies, the sector would see a battle between Amazon and the rest. In June 2016, it was reported that the family offices of Alibaba Group chairman Jack Ma and executive vice chairman Joseph Tsai, are exploring investments in India. Alibaba has reportedly held discussions to acquire online marketplace ShopClues as well.
Noida-based Paytm started out as a mobile payments and recharge business. The company has built its ecommerce marketplace during the last two years by selling apparel, footwear, smartphones, bus tickets, and movie tickets.
It has created a web of payments in the offline and online channels where consumers can transact via the Paytm wallet. In January 2015, Paytm announced that it had crossed 100 Mn Mobile Wallet users.
In August 2015, mcommerce company Paytm, received a license from the Reserve Bank of India to set up a payments bank. In April this year, IAMAI appointed Paytm Founder Vijay Shekhar Sharma, as the chairman of the newly formed Payments Banks Group at IAMAI. The company, through Paytm Payment Bank, is ready to go operational by October this year.
Alibaba Ecommerce One97 Communications Paytm Paytm Ecommerce Shopclues Vijay Shekhar Sharma


Kids ages 14 and under can earn $5 Half Price Books Bookworm Bucks for reading in June & July. Just read 300 minutes, turn in your completed reading log to your local store and earn your $5 HPB Bookworm Bucks reading reward for the month. You may turn in one log for both June & July.
Kids older than 14 can read a chosen title, write a review and earn HPB Bookworm Bucks. All reading logs must be turned in by August 30.


text:
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//     Runtime Version:4.0.30319.42000
//
//     Changes to this file may cause incorrect behavior and will be lost if
//     the code is regenerated.
// </auto-generated>
//------------------------------------------------------------------------------

namespace Guardtime.Ksi.Samples.Properties {

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        [global::System.Configuration.ApplicationScopedSettingAttribute()]
        [global::System.Diagnostics.DebuggerNonUserCodeAttribute()]
        [global::System.Configuration.DefaultSettingValueAttribute("http://verify.guardtime.com/ksi-publications.bin")]
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        [global::System.Configuration.ApplicationScopedSettingAttribute()]
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        [global::System.Configuration.ApplicationScopedSettingAttribute()]
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        [global::System.Configuration.ApplicationScopedSettingAttribute()]
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        [global::System.Configuration.DefaultSettingValueAttribute("pass")]
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                return ((string)(this["HttpSigningServicePass"]));
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        [global::System.Configuration.ApplicationScopedSettingAttribute()]
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        [global::System.Configuration.ApplicationScopedSettingAttribute()]
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Gorilla Breath by Humboldt Seed Organization is an Indica-dominant feminized cannabis strain much sought after by experienced growers. If you buy Gorilla Breath seeds, you will have the chance to enjoy one of the top-ten cannabis hybrid crosses in the USA.
Gorilla Breath seeds' parents are the famous GG4 and OGKB clone, so there's a lot to be happy about here. The resulting hybrid is a stunning marijuana plant that oozes quality and that yields buds wrapped in a delicious subtle OG/earthy aroma. A medium veg period is recommended indoors while outdoors the plant loves to be topped and LST technique being used. The production of resin is way above average.
The aroma of Gorilla Breath seeds reminds of earthy, gassy, sweet vanilla bean while the intense flavor is gassy with hints of pine, fuel, chocolate and diesel. This cannabis strain, which produces a powerful, long-lasting, clear, cerebral effect is one of the strongest on our menu.