Spring Break? Still looks like winter to me.
It's called Spring Break as it is supposed to coincide with the rapid melting of snow and the appearance of new buds on the trees, but as I sit here looking out of my window in Montreal neither seem to be happening right now. Just five hours south of here, in Boston, spring was slightly more advanced, but I have to say it was not imminent. There was less snow on the sidewalks and the temperature was a good few degrees warmer, but we're still a few weeks shy of seeing buds on branches.
'Tis no matter! For today it rains, and it rains a lot and that can only mean one thing – snow, you will wither and melt in rain's healthy warm onslaught! Be gone! Get thee hence to endless night….or something like that. Bottom line, rain accelerates spring by destroying snow far quicker than even the sun could do it on its own.
What do you mean the Bruins are better than the Habs?
Speaking of Boston, I did want to wrap up the trip by penning some last thoughts before I forget them. Four days is not a long time and it felt like even less. All too soon we were packing our bags trying to work out how we ended up with about 50% more luggage for the return trip. I think part of the problem was that the main shopping street, Newbury Street, was literally one block from our hotel. Combine this with the fact that the Canadian dollar is on par with the US and finally add in a good dose of "everything always seems to be cheaper in the US" and you've got yourself the perfect recipe for a major shopping spree. It doesn't hurt that there is no tax on goods that are valued at below $175, and even if you're buying something that is worth more than that, not saying we did, then you're only dinged a meagre 6%. Compared to the usual 15.75% we're used to here in Quebec, it all led us to believe that they were practically giving us the stuff. We would have been foolish to refuse such a hospitable gesture. Right?
OK so one can talk oneself into anything can't one? Sure, I didn't need to buy everything that I did, but I don't feel too guilty about it either. It's not like I have a problem. I mean I can stop whenever I want to. In fact, there is a lot to do in Boston that is not related to shopping and we discovered that four days is not nearly enough time to get it all done. One of the things we did enjoy as a family was the wonder of the New England Aquarium. Neither Marie nor I anticipated this being such a magical visit for us as it would be for the kids, but life under the sea is beautiful, serene, ugly and terrifying, all at the same time. I was reminded of the utter vastness of this planet and of frankly the tiny role that we, as humans, play in it. We're supposed to be sharing it, and as we were here second we should be asking permission to share, but we tend to want it all for ourselves and have little concern for our fellow creatures. When you see the variety of life that exists, some forms going back literally millions of years, it's hard not to stop and wonder at the immenseness of it all.
"I sentence you to life as a green, blue-eyed monster"
As breathtakingly beautiful as some of the fish are, you'll find a couple of truly ugly fellas as well, the most frightening being the Moray eel. Quite how this poor chump got to be so hideously grotesque is beyond me. I can only assume that he lost a bet somewhere along the way. The gent at the aquarium told us they had five of these monsters in the large tank, "But you'll be lucky if you get to see one! They hide during the day, and you probably wouldn't wanna see one anyway". Well, turns out that we did get lucky, if you can call it that, and I managed to snap a photo of surely the ugliest creature of them all. Trust me, those beady blue eyes follow you everywhere. It's spooky.
You'll eat well in Boston. You can be sure of that. Marie had done a bunch of very good research prior to our departure and we had all our restaurants planned out ahead of time, although not booked, thus allowing us the flexibility to change our minds should we walk past an establishment that looked too good to miss. The three nights we were there we ate at three very different restaurants and all of them were brilliant. By that I mean we would eat there again and I am recommending them to you right now.
Myers & Chang: a funky indie/diner setting that offers hot, tasty Asian food in a distinctly American setting. The food arrives as it comes off the line, so you never know what's going to land on the table next, but you can be sure of one thing- it'll be hot!
Island Creek Oyster Bar: only open for a short while, this restaurant has already established itself as a favourite amongst the locals, and with good reason. The ambience is brilliant, the food equally so. If you do happen to stay at the Eliot as we did, you can walk here.
Eastern Standard Kitchen: another walk from the hotel, this place evokes the Parisian bistro but with decidedly American sized portions. I would recommend sharing an appetizer and even then, following the main, you may not have enough room for dessert. We can eat, and we had to stop after the flat-iron steak and frites.
So Boston, we will be back. We did not have nearly enough time to see everything that we wanted to see, but that's OK as it gives us the perfect excuse to make the journey south sometime in the near future to pick up where we left off. À bientôt!


In your letter dated June 30, 2005, you requested a classification ruling. The submitted samples will be returned to you as requested.
Both styles are women's jackets constructed from 100 percent wool woven fabric.
Style FM4400 is composed of more than four panels and features long sleeves, a notched collar, shoulder pads and an unsecured full front opening.
Style FM4521 is composed of more than four panels and features a long sleeves with turnback cuffs, shawl collar, shoulder pads an unsecured full front opening. The jacket extends from the shoulder to below mid thigh. The garment is embellished with decorative stitching all over.
The applicable subheading for style FM4400 will be 6204.31.2010, Harmonized Tariff Schedule of the United States (HTS), which provides for women's or girls' suits, ensembles, suit-type jackets, blazers, dresses, skirt, divided skirts, trousers, bib and brace overalls, breeches and shorts (other than swimwear): suit-type jackets and blazers: of wool or fine animal hair: other: women's. The duty rate will be 17.5 percent ad valorem.
The applicable subheading for style FM4521 will be 6211.41.0055, Harmonized Tariff Schedule of the United States (HTS), which provides for track suits, ski-suits and swimwear; other garments: other garments, women's or girls': of wool or fine animal hair: jackets and jacket-type garments excluded from heading 6202. The duty rate will be 12 percent ad valorem.
Both styles fall within textile category designation 435. Quota and visa status are the result of international agreements that are subject to frequent renegotiations and changes. To obtain the most current information as to whether quota and visa requirements apply to this merchandise, we suggest that you check, close to the time of shipment, the "Textile Status Report for Absolute Quotas" available at our web site at www.cbp.gov. In addition, you will find current information on textile import quotas, textile safeguard actions and related issues at the web site of the Office of Textiles and Apparel, at otexa.ita.doc.gov.


text:
Archives : Carcassonne
Float Gently Through Turbulent Cathar History on Barge Trips in France
Languedoc: Rich History of a Beautiful Destination
The peaceful vineyard clad countryside of Languedoc hides a turbulent history. In the thirteenth century, a bloody crusade was launched by the Catholic Church over a Christian heresy called Catharism. Castles that are now viewed as scenic were once the last defense of a minority that didn't even speak French. At that time, southern France was a patchwork of smaller kingdoms and duchies with borders that shifted on a regular basis. One of them encompassing much of southern France was Occitania. The language of the area was known as "les langues d'oc"—which is the origin of the name for the region of Languedoc. Thus, the Cathars, in what is now France, were fighting not just for their religious freedom, but also for their independence as a cultural minority.
Visit Historical Treasures on Barge Cruise Excursions
Today you can explore this fascinating and disputed territory on the guided excursions included on our barge trips on the Canal du Midi. You will take an excursion to Minerve, the ancient hilltop village overlooking the confluence of two rivers where the peaceful Cathars were besieged by Simon de Montfort in 1210. A local museum re-creates the Cathar seige with a miniature diorama.
La Candela of Minerve is all that remains of the fort beseiged by Simon de Monfort in 1210.
140 Cathars perished by fire when they refused to renounce their faith.
Photograph by Beth Hanson, CanalBargeCruises.com.
Whether you make your home aboard a charter barge with your own private party or join other passengers on a hotel barge, you will visit the city of Carcassonne, which is hailed as the most complete medieval fortified city remaining in Europe today.
Carcassonne, a UNESCO World Heritage site, is the most well preserved walled city in Europe.
Photograph by Beth Hanson, CanalBargeCruises.com
From the deck of Anjodi or Athos as it passes through Beziers, you will have the opportunity to glimpse the hilltop city where all the townspeople were massacred when they refused to renounce their faith as demanded by Pope Innocent III and the French king Philippe II Augustus.
Beziers, where Simon de Montfort sacked the city and killed all the residents to eliminate the Cathars. Photo courtesy of European Waterways.
Aboard any of our Canal du Midi barges, you will have the opportunity to trace the footsteps of the Cathars as they peacefully and valiantly struggled to retain their independence.
Learn more about the engineering marvel of the Canal du Midi >
Discover Carcassonne – the jewel of Languedoc and the Canal du Midi >
If you're ready to float through history, contact us today to book a barge trip on the Canal du Midi.
Tags: Beziers, Canal du Midi, Canal du Midi Barge Cruise, Carcassonne, Cathar history, France, France History, Languedoc history, Minerve
Posted in Canal du Midi, Languedoc, Sightseeing and History | Leave a comment
Daily excursions are a highlight of a canal or river barge cruise. When cruising in the south of France on the Canal du Midi, you are immersed in a region which offers natural beauty, a rich history, and many lovely villages and small towns to explore on foot or by bike.
Carcassonne- a medieval city nestled in Languedoc vineyards
Carcassonne – a Canal du Midi Barge Cruise Attraction
Carcassonne, a stunning fortified town that's also a UNESCO World Heritage Site, is a highlight of the Canal du Midi barge trips. Though people have been living on this site for millennia, since before Roman times, Carcassonne is mainly known as a prime example of a European medieval fortified town – maybe the best of its kind in all of Europe. It is amazingly well-preserved and is yours to explore with all of its ramparts and towers.
St. Nazaire Basilica is known for its extraordinary stained glass
Carcassonne Sightseeing
What is there to see and do in Carcassonne?
Transport yourself to medieval times as you explore the amazing fortifications with its double walls and winding streets.
Find the bust of Madame Carcas at the Narbonne gate and learn about the legend of how she saved Carcassonne from a siege ending in the joyous ringing of bells ("Carcas sona")
Step into the ancient and majestic Basilica of St. Nazaire. The grand organ and colorful windows can't be missed. Simon de Montfort, leader of the crusade against the Cathars of Languedoc, was buried in the basilica before being moved by one of his sons.
Visit Chateau Comtal and walk the ramparts for beautiful views of the countryside.
Brave a visit to the Torture Museum, which displays a variety of medieval instruments of torture.
Try some of the local dishes, including cassoulet, which combines sausage, duck, and beans.
Be sure to bring a camera with you and take lots of photos of the architectural details. Soak in the atmosphere and get transported to another era. Your tour guide with the barge will give your visit more meaning, as you'll better understand the historical significance of this very strategic site.
Ancient Carcassonne overlooks the new city and the Canal du Midi
Contact us for more details about our barge trips on the Canal du Midi. We will take you to unforgettable locales.
Tags: Canal du Midi, Canal du Midi Barge Cruise, Carcassonne, France History, UNESCO Heritage Site

redpajama_set_name: RedPajamaCommonCrawl


Facebook, in all its wisdom, informs me that today is the day I complete one year as a blogger.
I did not realize that it already is a year since I though of started putting my quirky thoughts to words. More importantly, I am surprised to see that I was able to last this long, given that I have the attention span of a monkey.
I would like to thanks all my readers, who "liked" my posts and encouraged me to pen more entertaining and useful material. This is the main reason I was able to go on for this long.
I would also like to thanks a few people who were generous enough to donate money after reading my write-ups.
I would also like to thank my Mom, Dad, friends, colleges, office internet and the guy who keeps looking over my shoulder, just to see me struggle to get the typo right.
Also towards end of the month but absolutely I will donate to you!
I followed the link and loved the thank you! I also have the attention span of a monkey. If possible could you give my blog a read and a follow? Thank you :') I hope to stay as inspired as you!
Thanks for the read,like and follow ( I would have also liked to thank for the "donations: but I better not appear to be too needy:P ). I did go through your blog and liked it ( not talking about the button, mind you). I read you are a Gryffindor, good going. I think I am more Sytherin, but only because I like green and grey (and crave power).
One serious note, I myself started writing a blog because I was inspired by someone, so I am honored that you think I inspired you in some way.
Thanks so much! Haha crave power yeah deffo a slytherin trait!


In 2024, TA Boys Soccer will be 50 years old! The sport of soccer and the program have come a long way since 1974. Since 2000, some of you I have had the pleasure of coaching and others I have seen at the annual "Young Alumni" game in preseason or the "Old-timer's Kick-a-round" during the season. It is always a highlight of the season!
In recent years, the guys in the program has really found their game. In 2012, we opened the Eastern Trail Field as our primary varsity training space on campus. The 2015 season saw the program attain the #4 Seed in the South Region State Tournament. The team in 2017 enter the State Tournament as the #8 seed – defeating undefeated and #1 Seed South Portland in the Quarterfinals and exiting the tournament in the Regional Semifinal dropping a contest to Portland.
TA Boys Soccer offers 3 levels of play (Varsity - Junior Varsity - 1st Team).
For more information, please contact Coach Carlson.


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acldeliverynationwide.com
Quick Answer: How Is Land Used By Humans?
What are the 7 types of land use?
What are the four types of land use?
How land is being used?
Who owns the most land in the world?
Which country has no farming?
What are the 3 types of land?
How much land is there per person in the world?
What percentage of land is used by humans?
What is the biggest single human land use on Earth?
Which country has best soil?
How much land is needed to feed a person?
What do we get from land?
What are the five uses of land?
What country has the most habitable land?
What country has the richest soil in the world?
What are the benefits of land?
What types of land can you build on?
What are the uses of land class 10?
categorized land use into seven types: residential area, institutional area, industrial area, road greenbelt, roadside, park, and forest..
There are many types of land use we need to consider when studying the topic. Those types include recreational, transport, agricultural, residential, and commercial. Recreational land is used for human pleasure.
There are five types of land use: residential, agricultural, recreation, transportation, and commercial. People should make sure they use land responsibly to respect other people and our environment.
1. Roman Catholic Church: 70 million hectares. The largest landowner in the world is not a major oil magnate or a real estate investor.
According to a recent World Bank report, the countries with the smallest percentages of land used for agriculture today include Suriname, Greenland, Singapore, the Bahamas, the Seychelles, and Norway.
These are divided into four classifications: desert, forest, grassland and tundra. Land biomes are typically defined by the type of vegetation they possess, the types of animals that inhabit them and their climate, such as rainfall and temperature.
Subtracting this uninhabitable 57% (32,665,981 mi2) from the total land area leaves 24,642,757 square miles or 15.77 billion acres of habitable land. Divide this figure by the current human population of 7 billion (that's 7,000 million people) and you get 2.3 acres (about one hectare) per person.
The expansion of infrastructure and agriculture necessitated by this population growth has quickened the pace of land transformation and degradation. We estimate that humans have modified >50% of Earth's land surface.
While livestock takes up most of the world's agricultural land it only produces 18% of the world's calories and 37% of total protein. The expansion of agriculture has been one of humanity's largest impacts on the environment.
Land use statistics by countryRankCountryArable land (%)—World10.61India52.82United States16.83Russia7.335 more rows
The FAO reports 7.9 billion acres of arable land in the world; If it takes 3.25 acres to feed one person the typical western diet, then our 7 billion+ people would required over 21 billion acres, or the equivalent of almost three planet Earths. We used the conservative number of two planet Earths.
It includes all natural resources that we can get free from air, water and land. It covers the land surface, whether level or mountainous. It includes oceans, lakes and rivers, mineral deposits, rainfall, water-power, fisheries, forests and numerous other things which nature provides and man uses.
Types of land uses. There are many different categories when it comes to land use. The five most common uses are recreational, transport, agricultural, residential and commercial. Understanding the specifics of each one can help when planning on investing in property.
World15,749,300RankCountryLand km21United States1,650,0622India1,451,8103China1,385,90547 more rows
Found in Ukraine, parts of Russia and the USA, mollisols are some of the world's most fertile soil. This type of soil includes black soils with high organic content. Vertisols – 2.5% of the world's ice-free land. This type of soil is found in India, Australia, sub-Saharan Africa, and South America.
Land Conservation BenefitsProtection of water resources.Providing open spaces and parks for our urban communities.Creating and enhancing outdoor recreation opportunities statewide.Preserving working farms and forests.Protecting wildlife habitat.
What are the main types of self build plot?1 Brownfield land. The government focuses much new housing on brownfield sites (previously developed land), so local councils should look favourably on plans for these plots. … 2 Greenfield land. … 3 Garden plots. … 4 Buy to demolish. … 5 Designated areas.
Land resources are used for the following purposes:Forests.Land not available for cultivation: Barren and waste land; land used for buildings, roads, etc.Other uncultivated land: Permanent pastures and grazing lands.Fallow land: Left fallow for regaining the fertility of the soil.More items…•
Quick Answer: Why Does Hawaii Have Wild Chickens?
Can you eat wild chickens? There is absolutely nothing
Question: Is There Siding That Looks Like Logs?
Should you do windows or siding first? Installing Siding
Question: What Is Difference Between BRD And FRD?
What is the difference between FSD and BRD?
What Movie Does Tris Cut Her Hair?
Does Shailene Woodley do her own stunts? Everything
Quick Answer: Can I Move Out Before My 30 Day Notice?
What happens if you don't give 30 days notice
Quick Answer: Who Is Responsible For Paying A PCN?
Can a PCN be enforced? Parking Charge Notices are the
Question: What Are The State Obligations To Human Rights?
What are state responsibilities? States must take responsibility
Quick Answer: How Much Are Dealer Fees And Taxes On A Used Car?
What fees do dealers charge on used cars?
How Much Money Does A Ferrari Mechanic Make?
What is the highest paying job? Highest Paying OccupationsOCCUPATION2019
Quick Answer: Where Are Pesticides Used?
What crops are pesticides used on? Farmers growing
What'S Higher Than A God?
Who is real God in world? In the Hebrew Bible and Judaism
Question: How Long Can You Park In Handicap?
What to do if someone is parked in a handicapped spot?
Quick Answer: Is Salt Good For The Garden?
Does Salt Kill soil? Salt kills plants by osmosis. …
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Q: Help me understand mk-heartbeat Seconds_Behind_Master from SHOW SLAVE STATUS is considered an unreliable measure of Slave lag. mk-heartbeat is often offered as a reliable alternative.
Now mk-heartbeat does not even need the Slave to be running.
http://www.maatkit.org/doc/mk-heartbeat.html
Excerpt:

mk-heartbeat is a two-part MySQL and PostgreSQL replication delay monitoring system that doesn't require the slave to be working (in other words, it doesn't rely on SHOW SLAVE STATUS on MySQL).

So my understanding is that you create a DB/table on the Master, run mk-heartbeat with --update like so:
./mk-heartbeat -D heart --table beat -u heartbeat -p XXXXXXXXX --update -h 192.168.2.80

And then on the Slave you point mk-heartbeat at the DB/table on the Master (i.e. you do a GRANT statement on the Master to give the Slave privileges) and run with --monitor like so:
./mk-heartbeat -D heart --table beat -u heartbeat_slave -p XXXXXXXXX --monitor -h 192.168.2.80

I have done just this and even when updating over and over the 2.8M+ rows in the MySQL sample employees salaries table (which creates Slave lag, at least according to the unreliable Seconds_Behind_Master) I never see the mk-heartbeat --monitor change from:
0s [  0.00s,  0.00s,  0.00s ]

Maybe it is the case that I haven't produced enough lag and that as per the mk-heartbeat docs the replication events are propagating in less than half a second and I can expect to see zero seconds of delay:

mk-heartbeat has a one-second resolution. It depends on the clocks on the master and slave servers being closely synchronized via NTP. --update checks happen on the edge of the second, and --monitor checks happen halfway between seconds. As long as the servers' clocks aren't skewed much and the replication events are propagating in less than half a second, mk-heartbeat will report zero seconds of delay.

(My servers' clocks are using NTP and are in sync.)
But Seconds_Behind_Master is hundreds of seconds behind so I would think they are not propagating in less than half a second so I'm still uncertain whether I am getting an accurate view of the mk-heartbeat utility or not.
Would love to hear from anyone that has deployed this tool for monitoring their MySQL replication.
Thanks in advance.
Cheers

A: You're close, but your problem is you have both instances pointing at the master.   What you want is one instance updating the master every second, and the second instance reading the slave every second.
Also note it does not need to run on the actual database servers at all, it uses a regular mysql client connection.   I run mine from my cacti server.  Here's my sanitized /etc/rc.local for an example:

/usr/bin/mk-heartbeat -D maatkit -u maatkit -paardvark --update -h sql-master.fake.net --daemonize
/usr/bin/mk-heartbeat -D maatkit -u maatkit -paardvark -h sql-slave.fake.net --monitor --file /tmp/sql-slave.heartbeat --daemonize

A: Here is what I'm doing:
mk-heartbeat -D maatkit -u maatkit -p pass --update -h master
mk-heartbeat -D maatkit -u maatkit -p pass -h slave --monitor

When I run the above the output snippet is
1618s [ 53.92s, 10.78s,  3.59s ]
1619s [ 80.90s, 16.18s,  5.39s ]
1620s [ 107.90s, 21.58s,  7.19s ]
1621s [ 134.92s, 26.98s,  8.99s ]
1622s [ 161.95s, 32.39s, 10.80s ]
1623s [ 189.00s, 37.80s, 12.60s ]
1624s [ 216.07s, 43.21s, 14.40s ]
1625s [ 243.15s, 48.63s, 16.21s ]

The numbers just slowly go up.
Does the heartbeat table need to be replicating to the slave?  Is that what I'm missing?

redpajama_set_name: RedPajamaStackExchange


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text:
Q: How can I draw a border around the viewport using GL_LINES? I'm having trouble getting my shader to run on the perimeter of a texture. I'm following along with https://learnopengl.com/ as a guide and using indexed vertices to draw line primitives. The problem is only the right side and bottom lines are drawn, top and left are missing.
I've written a small program to demonstrate this by trying to draw a red border around a black viewport. It's mostly the same skeleton code from learnopengl.com.
Here's the shader:
#version 330 core

out vec4 FragColor;

void main()
{
    FragColor = vec4(1, 0, 0, 1);
}

And the C++ code:
#include <glad/glad.h>
#include <GLFW/glfw3.h>

#include <learnopengl/shader_s.h>

#include <iostream>

void framebuffer_size_callback(GLFWwindow* window, int width, int height);
void processInput(GLFWwindow* window);

const unsigned int SCR_WIDTH = 800;
const unsigned int SCR_HEIGHT = 800;

struct vaoinfo
{
    unsigned int VBO, VAO, EBO;
    vaoinfo() : VAO(0), VBO(0), EBO(0)
    {}
};

void create_vao(vaoinfo& info)
{
    glGenVertexArrays(1, &info.VAO);
    glGenBuffers(1, &info.VBO);
    glGenBuffers(1, &info.EBO);
}

void init_vao(vaoinfo& info, float* vertices, int num_vertices, int* indices, int num_indices)
{
    glGenVertexArrays( 1, &info.VAO);
    glGenBuffers( 1, &info.VBO);
    glGenBuffers( 1, &info.EBO);
    glBindVertexArray(info.VAO);
    glBindBuffer( GL_ARRAY_BUFFER, info.VBO);
    glBufferData( GL_ARRAY_BUFFER, sizeof(float) * num_vertices, vertices, GL_STATIC_DRAW);
    glBindBuffer( GL_ELEMENT_ARRAY_BUFFER, info.EBO);
    glBufferData( GL_ELEMENT_ARRAY_BUFFER, sizeof(int) * num_indices, indices, GL_STATIC_DRAW);
    glVertexAttribPointer( 0, 3, GL_FLOAT, GL_FALSE, 3 * sizeof(float), (void*)0);
    glEnableVertexAttribArray( 0);
    glBindVertexArray( 0);
}

int main()
{
    // glfw: initialize and configure
    glfwInit();
    glfwWindowHint(GLFW_CONTEXT_VERSION_MAJOR, 3);
    glfwWindowHint(GLFW_CONTEXT_VERSION_MINOR, 3);
    glfwWindowHint(GLFW_OPENGL_PROFILE, GLFW_OPENGL_CORE_PROFILE);

    // glfw window creation
    GLFWwindow* window = glfwCreateWindow(SCR_WIDTH, SCR_HEIGHT, "LearnOpenGL", NULL, NULL);
    if (window == NULL)
    {
        std::cout << "Failed to create GLFW window" << std::endl;
        glfwTerminate();
        return -1;
    }
    glfwMakeContextCurrent(window);
    glfwSetFramebufferSizeCallback(window, framebuffer_size_callback);

    if (!gladLoadGLLoader((GLADloadproc)glfwGetProcAddress))
    {
        std::cout << "Failed to initialize GLAD" << std::endl;
        return -1;
    }

    Shader borderProgram("default.vert.glsl", "border.frag.glsl"); // you can name your shader files however you like

    float vertices[] = {
       1.f,  1.f, 0.0f,  // top right
        1.f, -1.f, 0.0f,  // bottom right
        -1.f, -1.f, 0.0f,  // bottom left
        -1.f,  1.f, 0.0f,   // top left
    };

    vaoinfo T, B, L, R;
    int top[] = { 3,0 };
    create_vao(T);
    init_vao(T, vertices, 12, top, 2);

    int bottom[] = { 1,2 };
    create_vao(B);
    init_vao(B, vertices, 12, bottom, 2);

    int left[] = { 2,3 };
    create_vao(L);
    init_vao(L, vertices, 12, left, 2);

    int right[] = { 0,1 };
    create_vao(R);
    init_vao(R, vertices, 12, right, 2);

    glBindFramebuffer(GL_FRAMEBUFFER, 0);

    while (!glfwWindowShouldClose(window))
    {
        // input
        processInput(window);

        glClearColor(0.f, 0.f, 0.f, 0.f);
        borderProgram.use();

        glBindVertexArray(T.VAO);
        glDrawElements(GL_LINES, 2, GL_UNSIGNED_INT, nullptr);

        glBindVertexArray(B.VAO);
        glDrawElements(GL_LINES, 2, GL_UNSIGNED_INT, nullptr);

        glBindVertexArray(L.VAO);
        glDrawElements(GL_LINES, 2, GL_UNSIGNED_INT, nullptr);

        glBindVertexArray(R.VAO);
        glDrawElements(GL_LINES, 2, GL_UNSIGNED_INT, nullptr);

        glfwSwapBuffers(window);
        glfwPollEvents();

        Sleep(16);
    }

    glfwTerminate();
    return 0;
}

void processInput(GLFWwindow* window)
{
    if (glfwGetKey(window, GLFW_KEY_ESCAPE) == GLFW_PRESS)
        glfwSetWindowShouldClose(window, true);
}

void framebuffer_size_callback(GLFWwindow* window, int width, int height)
{
    glViewport(0, 0, width, height);
}

Edit: I figured out the issue...kinda. I was under the impression that when addressing vertices (I think it's called "local space" when creating a vao) the range of coordinates for x and y were [-1,1]. But apparently it's actually [-m.x,1] and [-1,m.y] where m=(1-1/w, 1-1/h). Is this assumption correct?

A: The X and Y co-ordinates -1 and +1 in clipspace (which is what you draw) map to the very edges of the viewport.
The problem is, when you draw a line on the very edge of a pixel, OpenGL needs to decide which of the two pixels shared by that edge is going to produce a fragment. As far as the OpenGL specification goes, an actual OpenGL implementation is free to choose whichever behaviour it wants, so long as certain conditions are met, for example both adjacent pixels should not produce a fragment, only one of them should.
The fact that you do not see the pixels of all four edges of the viewport generating fragments for your lines is that an OpenGL implementation also needs to be consistent about that tie-breaking rule.
When the viewport were just one pixel larger to the left and to the top (where you currently don't see any pixels of the line), then you'd see the line's pixels there.
If you want to make sure that you see all four lines at all four edges of the viewport, you must adjust the coordinates of the lines such that they cross the center of the pixel (as opposed to the edges between two adjacent pixels).
You can do that by offsetting your vertex coordinates by effectively half a pixel. Since clip space has an extent of 2 units along each X and Y axes, you need to then offset the negative vertex co-ordinates by 1.0f/windowWidth respectively 1.0f/windowHeight and the positive co-ordinates by -1.0f/windowWidth respectively -1.0f/windowHeight.
It actually helps if you draw a small grid onto paper, mark the very left/bottom edge as -1 and the very right/top edge as +1 and then use simple math to figure out the positions of the centers of the pixels on the edges. This will then be the coordinates of the vertices you need to draw.


Meditech Technologies India Pvt. Ltd is the largest manufacturer and exporter of Diuresis Cage for Small Rodents & Trolley. Especially useful for urine collection experiments The cage is provided with cage body, floor, Funnel, Water bottle and waste water collection tube. Waste water is collected in the P.P. tube. Cage body is fitted with tag holder for identification purpose. In this, urine and feces falls on the S.S. Funnel. On S.S. funnel, one sieve of S.S. is fixed which allows only passage of urine and not feces leading to collection of feces above the sieve and urine at the bottom in the P.P. beaker.
• Waste water collection tube P.P.
• Urine collection beaker P.P.
• Overall Approx Dimensions: 260x300x420mm.
Made of S.S. 304 material and suitable to hold 6-8 metabolic cages for small rodents (economy model) DUC-1.


Just when you thought it was safe to go in the…..pool?
Shark Pool, from Woodhead Entertainment, is a brilliant independent short that starts out with the same grossly over-done concept of a group of teens gathering for a party that has played repeatedly since the counselors first gathered at Camp Crystal Lake.
🦈 Don't go in the pool!
Complete with all of the teen horror comedy essentials including a jeep full of wassailers, Styrofoam cooler, and red solo cups present en masse. Think Idle Hands (Seth Green, Devon Sawa), except with a pool, a shark, and well never mind. Its really nothing like Idle Hands, but it is funny as 💩 .
The first one in is rotten …. bait? It is literally not more than seconds into the movie when a bikini clad blonde (Sarah Baldwin – Dads) shouts "There's a shark in the Pool". Some dude, who reminds me of everyone I hung out with in high school, steps up and takes charge demanding that everyone immediately get into the pool – YES, with the shark… but, he does advise caution. Huh?
The only way this film could have been better is if they had actually made a movie to go along with the trailer. Pool Shark also stars Artie Baxter (Gridiron Gang), Kojo Asiedu (Rizzoli & Isles), Dan Perrault (producer American Vandal), Makinna Ridgway (Grimm), and Sean Carrigan (John Carter).
← Does Liquid Chlorine Raise pH?


She won't break you like those other girls will. That's exactly why you're terrified of her. She could make you happy. And you know being happy is the most terrifying thing in the universe. Once you're happy it can be taken from you.


Leading law firm, Russell McVeagh, has been recognised at last night's 2018 New Zealand Law Awards, winning both International Deal of the Year and New Zealand Deal of the Year awards for the Lattice Energy acquisition by Beach Energy.
Russell McVeagh acted for Origin Energy in the A$1.585b major trans-Tasman energy transaction which saw its conventional upstream oil and gas production business, Lattice Energy, acquired by Australian oil and gas company Beach Energy. The deal was led by Russell McVeagh partners Mei Fern Johnson and David Raudkivi, with Senior Associate Gareth Worthington. In May this year, this deal also won Energy & Resources Deal of the Year at the Australasian Law Awards held in Sydney.
Russell McVeagh Board Chair Malcolm Crotty said he was delighted with this recognition which acknowledges the firm's talented people and their expertise at the forefront of New Zealand's most significant and complex transactions.
The firm's Corporate Advisory team and a number of high-profile transactions had also been recognised as finalists, including Russell McVeagh's role advising Fidelity Life, the largest New Zealand owned life insurer, on the NZ Superannuation Fund's $100 million cornerstone investment. Involving complex arrangements for issue and subscription of new shares and the sale and purchase of existing shares, the transaction was led by partners Pip Greenwood, Ian Beaumont, Tom Hunt and Fred Ward.
Russell McVeagh had also advised on Oceania Healthcare's $200m IPO which was the only IPO on the NZX and dual listing (NZX and ASX) in the New Zealand market last year. Led by partners Pip Greenwood and Ben Paterson, this deal won INFINZ's NZ Equity Market Transaction of the Year 2018.
The firm would like to extend congratulations to all of last night's winners and finalists, including the winners of the Russell McVeagh sponsored In-house Team of the Year, Wellington City Council, Fonterra's Andrew Cordner who won In-House Lawyer of the Year, and ANZ who won Financial Services In-House Team of the Year.
The annual awards took place at a ceremony held at the Cordis in Auckland and brought together industry leaders to celebrate excellence in the legal profession and recognise the outstanding achievements of firms and in-house teams across New Zealand.


text:
Guido Cafmeyer (Torhout, 1924 - 1994) was een Belgisch toneel- en stoetenregisseur.

Levensloop
Guido Cafmeyer was een zoon van Michel Cafmeyer en Albertina Blondeel. Hij trouwde met Maria Luyssaert (1913-1999).
Hij was oorspronkelijk banketbakker. Bij de dood van zijn vader in 1940 onderbrak hij zijn studies aan het Sint-Jozefsinstituut in Torhout en ging in de leer voor banketbakker. Zijn vader was een groot toneelliefhebber en toen hij zes was kreeg Guido een eerste rolletje. Hij werd tevens amateur-acteur in Toneelkring Sint Rembert en werd er in 1949 voorzitter en regisseur.

In 1949 schreef hij zich in aan het conservatorium in Gent. Vanaf twee uur 's nachts tot de middag was hij bedrijvig in de bakkerij en trok dan per trein naar Gent, om tegen eenentwintig uur weer thuis te komen. Hij verliet de school in 1954 als laureaat voordracht en toneel.

Het Sint-Jozefsinstituut in Torhout bood hem twee lesuren aan, vanaf 1958 zestien uren en vanaf 1959 een volledige lesrooster, in dictie en voordracht. Dit was het einde van Cafmeyer als banketbakker.

In 1959 speelde hij met groot succes de hoofdrol in Koning Oedipus. Hij kreeg voortaan regieopdrachten vanwege het provinciebestuur en leidde de Torhoutse Toneelkring Sint Rembert naar de categorie 'Uitmuntendheid'.
De kring werd tot vijftienmaal prijswinnaar bij het Landjuweel. Onder de leiding van Cafmeyer werd de kring viermaal de eerste in de rangschikking voor het Landjuweel.

Guido Cafmeyer is de vader van de leraar dictie en toneel- en stoetenregisseur Bart Cafmeyer (°1956) (Kattenstoet, Ieper) en de grootvader van actrice Maaike Cafmeyer.

Realisaties

Toneel
In 1949 regisseerde Cafmeyer voor het eerst bij Sint-Rembert. Het werd Patsy, waarbij het uitsluitend mannengezelschap voor het eerst gemengd werd.

Talrijke toneelstukken werden onder zijn regie door Sint-Rembert opgevoerd:
 Ketty liegt nooit (1950)
 Onder één dak (1950)
 Negentien jaren (1951)
 Een inspecteur voor u (1951)
 Christine Lafontaine (1952)
 Peegie (1952)
 Kermisvolk op Kerstmis (1953)
 Dolle Hans (1954)
 Mevrouw Pilatus (1954)
 Tien kleine negertjes (1955)
 De klucht van de  brave moordenaars (1955)
 De derde dag (1956)
 De mooiste ogen  van de wereld (1956)
 De laatste op het schavot (1957)
 Zo is vader (1959)
 De geschiedenis van een kassier (1959)
 Glazen speelgoed (1960)
 De engel van het pandjeshuis (1960)
 Ons stadjes (1961)
 Arsenicum en oude kant (1962)
 De derde dag (1962)
 De dag van Talavera (1963)
 Mijn geweten en ik (1963)
 Dood van een handelsreiziger (1964)
 Dokter Knock (1965)
 Pas op dat je geen woord zegt (1966)
 Jonkvrouw Edelwater (1967)
 Het systeem Fabrizzi (1967)
 Een geur van bloemen (1968)
 Yerma (1969)
 Stuur me geen bloemen (1970)
 Vrijdag (1971)
 De familie Tot (1972)
 Reinaert de Vos (1973)
 Alles voor de tuin (1974)
 August, August, August (1975)
 Het reservaat (1977)
 Harten twee, harten drie (1977)
 De dag dat de paus ontvoerd werd (1978)
 Liefde (1980)
 Lucien en Martine (1981)

Cafmeyer voerde ook de regie voor toneelgroepen in onder meer  De Panne, Knokke, Meulebeke en Roeselare.

Stoeten en processies
 Heilig Bloedprocessie, Brugge. Bij de grondige vernieuwing van de processie in 1958 werd Cafmeyer regisseur, met als geestelijke inspirator Arthur Camerlinck, rector van de basiliek.
 Zeewijding, Oostende
 Credostoet, Torhout
 Openluchtspel, Blankenberge

Eerbetoon
In 1984 werd hem de Torhoutse Gouden Feniks toegekend, voor zijn prestaties als lesgever dictie en taalgebruik, stoetenbouwer, lid-regisseur-voorzitter van de Toneelkring St.-Rembert, waarmee hij menigmaal het Koninklijk Landjuweel won.

Literatuur
 Walter DE TAEYE, Regisseur Guido Cafmeyer tweemaal landjuweel, in: Vlaanderen, 1969.

Vlaams toneelregisseur
Vlaams stoetenregisseur

redpajama_set_name: RedPajamaWikipedia


All-in-one, single platform simplicity for after-market service providers.
MD is a single platform that supports multiple repair and refurbishment services, for up to 40 devices simultaneously. The platform enables triage with automated and configurable flows, wipe to ensure that data is completely unrecoverable, and accuracy verification with audit trails and reporting. MD is a software-based solution that includes a management console that enables users to control and customize flows per station.
Expedite and automate the triage process. Identify and correct device hardware and software issues, quickly and accurately.
Make mobile data irrecoverable. The only certified purge-level wipe, meeting National Institute of Standards & Technology guidelines.


text:
Caplan, E.S. et al.
Identification and treatment of infections in multiply traumatized patients.
Trauma is the leading cause of death among young adults, and infection is a leading complication in multiply traumatized patients. All antibiotic use and all infections among 1,009 patients admitted to the Maryland Institute for Emergency Medical Services Systems over a six-month period were reviewed. The vast majority of patients had sustained high-speed automobile trauma and had blunt injuries. All antibiotics were given by the infectious diseases consultants under predetermined protocols. During this time period, 175 infections and 76 bacteremias were identified. Thirty-three percent of the antibiotic use was for prophylaxis. Prophylactic antibiotics were used for open fractures, in which a cephalosporin was used; for abdominal trauma, in which an aminoglycoside and clindamycin or cefoxitin alone was used; and for penetrating open fractures of the oral cavity, in which penicillin was used. As therapy, the aminoglycosides were used in 25 percent, the cephalosporins in 21 percent, the penicillins in 39 percent, and other antibiotics in 15 percent of the cases. The organisms identified as causing infection were Staphylococcus aureus (25 percent), Escherichia coli (18 percent), Enterobacter species (17 percent), Pseudomonas species (12 percent), and Klebsiella species (11 percent). The sites of infections were primary bacteremia (11 percent), vascular lines (21 percent), the central nervous system (3 percent), the lower respiratory tract (13 percent), the paranasal sinuses (6 percent), the urinary tract (19 percent), surgical wounds (11 percent), the abdomen (7 percent), and other sites (9 percent). More than 82 percent of the infections that occurred were nosocomial in origin and were related to the various procedures used for monitoring and therapy in these critically ill patients. Infections of the abdominal cavity and the lower respiratory tract accounted for eight of the 10 infection-related deaths in these patients.[1]
Identification and treatment of infections in multiply traumatized patients. Caplan, E.S., Hoyt, N.J. Am. J. Med. (1985) [Pubmed]


text:
Yurts, Cabins & Hammock Camping
East Canyon and the surrounding area are rich in pioneer history. The Donner Party, also called the Donner-Reed group, was a group of farmers from Iowa and Illinois going west to find fertile land for their crops. On their way to California, they passed through East Canyon in 1846, the first wagon train to pass through this way. Many obstacles, including high brush and rocky obstacles, slowed them down a great deal. Not realizing the harsh conditions they would encounter while on their trek, only 47 of the original 87 reached their destination.
One year after the Donner Party passed through East Canyon, Mormon pioneers followed that same trail, however, this time was much easier due to the trail work the Donner party had accomplished. Four days later, Brigham Young and his group of pioneers used this trail to get to the Salt Lake valley.
Many people used the Donner-Mormon route over the years, including the Overland Stage and the Pony Express.
Opened to the public as a state park in 1962.
Park Elevation: 5,700 feet
Hours 6 a.m. to 10 p.m.
Phone: 801-829-6866 Fax: 801-829-3835 Management:
Chris Haramoto, Park Manager


text:
Home › Crosby & Nash Self Titiled CD
Crosby & Nash Self Titiled CD
Long time compatriots and bandmates David Crosby and Graham Nash have joined forces yet again to release the oddly named Crosby/Nash 28 years after their last studio effort, Whistling Down the Wire. This double-disc is certainly worth the wait, despite the fact that most of the 20 songs are profoundly introspective and tinged with an elegant melancholy and sense of regret for an idealized past. To their credit, after four decades, Crosby and Nash are still in perfect voice, and remain graceful foils for one another, although some of the songs don't do justice to their prodigious talents. A handful are without focus and seem to be impressions in search of a hook, save the lovely, ethereal "Lay Me Down" (penned by Crosby's son, James Raymond) and the rather esoteric '60s throwback "Luck Dragon," with its elegant space jam ending. Nash's contributions are a bit more prosaic, and seem to be autobiographical ruminations about middle age, except the chilling environmental cautionary tale, "Don't Dig Here" and haunting post-9/11 song, "Half Your Angels." But the disc really comes alive when the duo shows their old ire, "They Want It All," a clear potshot at corporate greed and politics, and a wrenching read of "My Country 'Tis of Thee." --Jaan Uhelszki
It's been almost thirty years since venerable rock legends David Crosby & Graham Nash recorded the last of their three endeavors as a duo (1976's Whistling Down The Wire). The studio band for this project is a hybrid of old friends & new friends. Crosby & Nash have surrounded themselves with some of the most talented musicians they have come across in the business. Russ Kunkel, drummer from their 70's projects, & his son Nathaniel, are co-producers of the album of all new material. Crosby/Nash will be embarking on an extensive US tour with Stephen Stills this summer & will be hard at work.
Through Here Quite Often
Jesus Of Rio
Other Side Of Town
Half Your Angels
They Want It All
Don't Dig Here
Penguin In A Palm Tree
Shining On Your Dreams
Live On (The Wall)
My Country 'Tis Of Thee (Originally used in an episode of NBC's "The West Wing")


text:
Q: Implement 'toggle class' functionality on a list of elements with React I'm struggling with implementing 'toggle class' functionality in React.
I have the NavSidebar component which is an unordered list ul. My NavListItem component is list item li.
When the list item is clicked I need to give the class name active to the clicked li and other list elements should get an empty class name.
Here's what I've come up with by far:
class NavListItem extends React.Component {
  constructor(props) {
    super(props);
    this.state = { active: false };
  }

  setActive(bool) {
    this.setState({ active: bool });
  }

  render() {
    let index = this.props.key;
    let item = this.props.item;
    return (

        {item}

    );
  }
}

class NavSidebar extends React.Component {

  constructor(props) {
    super(props);
  }

  render () {

    let items = this.props.navItems.map( (item, index) => {
      return (
        <NavListItem key={index} item={item} setActive={true} />
      );
    });

    return (

              {items}

                 Back Home

    );
  }
}

NavSidebar.propTypes = {
  navItems: React.PropTypes.array
};

Unfortunately, this doesn't work, it never even touches the className of the elements and I can't come up with the working solution.
Could you please help me with that?

A: There is no error message here?
onClick={this.setActive(this.props.setActive).bind(this)}

Because you are binding undefined, result of calling this.setActive(this.props.setActive)
and even if you remove the bind, it will not work as the click handler will be undefined. Also, the state should never be modified inside render.
In any case, because you want to update more than one item (the new selected one and the old one), the parent should be responsible of this and should:

*

*activate the clicked item

*deactivate all others

*re-render the list

Something like this (not tested):
class NavListItem extends React.Component {
  constructor(props) {
    super(props);
  }

  setActive(bool) {
    this.props.onItemActive(this.props.item);
  }

  render() {
    let item = this.props.item;
    return (

        {item}

    );
  }
}

class NavSidebar extends React.Component {

  constructor(props) {
    super(props);
    this.state = {activeItem: null};
  }

  onItemActive(item) {
    this.setState({activeItem: item};
  }

  render () {
    let self = this;
    let items = this.props.navItems.map( (item, index) => {
      return (
        <NavListItem key={index} item={item}
                     onItemActive={self.onItemActive.bind(self)}
                     active={item === self.state.activeItem} />
      );
    });

    return (

              {items}

                 Back Home

    );
  }
}

NavSidebar.propTypes = {
  navItems: React.PropTypes.array
};


The X Games SLOPESTYLE Eyeglasses by X Games has many terrific features. A full plastic frame that may contain some metal for structual integrity. This item is eligible for prescription lens installation. It's nature's color for water and sky. between black and white in color. The length of the temple pieces are 135 millimeters. Black is the most common color seen in the dark. The dappled amber tones of tortoiseshell have timeless class. Item ranges in price between $60 and $100. the color of passionate love, seduction, violence, danger, anger, and adventure. This item is eligible for custom polarized or non-polarized clip-on sunglass creation. The width of the bridge of this frame is 18 millimeters. Full Rim glasses cover the lens on all sides. This item is eligible for prescription lens installation and has a high enough vertical width for your bi-focal or progressive lens. One of our most popular items. The eyesize of this item is 50 millimeters.
The X Games SLOPESTYLE Eyeglasses is found in the Eyeglasses category and is offered in terrific option(s). Color 001 Black Red,Color 215 Tortoise,Color 300 Cargo Grey,Color 412 Navy Red,Size 50 - 18 ¬ 135.


Dear friends wow India is a unique organization and you (its volunteer) are a unique breed of human beings who have volunteered to look after "the women of India" Colleagues please come forward and spare just one hour of yours per week for the women of India.
Our women are still underprivileged.
Over 1 lakh women die every year of pregnancy and childbirth related causes in India.
99% in developing countries (360 women die in India alone).
About one death per minutes due to pregnancy complications in India.
MMR in India about 360-400 (upto 700 in some state) /100,000 births.
25% due to bleeding,15% infection,12% PIH and eclampsia, 8% obstructed labour and 13% unsafe abortions.
15% women get critical ill during pregnancy and will require critical medical care.
Only 34% of birth in our country are attended by skilled help.
Only 15% delivery have doctor's help.
India spend a mere 0.9% of GDP on health. Only 4 countries in the word are worse then us.
The neglected tragedy of MMR is not just a health problem, it is a fight equations of women's human rights.
Unfortunately our health services still lag behind, specially for women. We need to take drastic actions.
It is time for all of us educated women to wake up and start thinking that our responsibility now extends toward other underprivileged girl rather than only taking care of ourselves and our family.


Washington Irving (April 3, 1783 – November 28, 1859) was an American author of the early nineteenth century. Best known for his short stories The Legend of Sleepy Hollow and Rip van Winkle (both of which appear in his book The Sketch Book of Geoffrey Crayon), he was also a prolific writer of essays, biographies, and other literary forms as well. He and James Fenimore Cooper were the first American writers to earn acclaim in Europe, and Irving is said to have mentored authors such as Nathaniel Hawthorne, Henry Wadsworth Longfellow, and Edgar Allan Poe. In the 1840s he served as the United States Ambassador to Spain. He is also known for speaking out against the unfair treatment of Native Americans.
His famous home of Sunnyside just south of the Tappan Zee Bridge in Tarrytown, New York is still standing. The original house and the surrounding property were once owned by eighteenth-century colonialist Wolfert Acker, about whom Irving wrote his sketch Wolfert's Roost (the name of the house).
Irving's famous home Sunnyside in Tarrytown, New York.
Irving was born in Manhattan. Irving's parents were William Irving of Shapinsay, in the Orkneys, a petty officer in the Royal Navy, and Sarah née Sanders. His first book was A History of New-York from the Beginning of the World to the End of the Dutch Dynasty, by Diedrich Knickerbocker (1809), a sly satire on self-important local history that brought "Knickerbocker" into the American lexicon, and then wider English usage.
When he was 32 years old, Irving traveled to Europe. A lawyer, he was a member of the American diplomatic staff in Britain and in Spain. He spoke fluent Spanish, which served him well in his writings on that country, and he could read several other languages, including German and Dutch. He was a prolific essayist who wrote widely respected biographies of George Washington, the prophet Muhammad, and others, and he wrote a number of books on fifteenth-century Spain on subjects such as Christopher Columbus, the Moors, and the Alhambra. While in Europe, Irving dabbled in the theater, even serving as manager of the famed Globe Theatre for a period of time.
In 1819 and 1820 he published The Sketch Book of Geoffrey Crayon, which includes his best known stories, The Legend of Sleepy Hollow and Rip van Winkle. During this stay in Europe he was a member of the American Legation to England but in his spare time he traveled to the continent and widely read Dutch and German folk tales. The pieces for The Sketch Book were originally written by Irving in Europe and were sent to his publishers in New York for publication in periodicals in the United States. While in England, his sketches were published in book form by British publishers without his permission and from then on he published in Europe and the U.S. concurrently to protect his copyright.
Rip Van Winkle was written overnight while Irving was staying with his sister Sarah and her husband, Henry van Wart in Birmingham, England, a place that also inspired some of his other works. Bracebridge Hall or The Humorists, A Medley is based on Aston Hall there.
Irving is also the author of The Adventures of Captain Bonneville and Astoria and used firsthand accounts of these American west journeys, although most readers continue to believe they are "embellished" history.
We send our youth abroad to grow luxurious and effeminate in Europe; it appears to me, that a previous tour on the prairies would be more likely to produce that manliness, simplicity, and self-dependence, most in unison with our political institutions.
His second Western book was Astoria; he wrote it during a six-month stay with the then-retired John Jacob Astor. It was a worshipful account of Astor's attempt to establish a fur trading colony at present-day Astoria, Oregon.
During Irving's stay with Astor, Benjamin Bonneville paid a visit. His tales of his three years in Oregon Country were said to have enthralled Irving. A month or two later, when Irving encountered Bonneville in Washington, D.C., Bonneville, struggling to write about his journey, decided instead to sell his maps and notes to Irving for $1,000. Irving used that material as the basis for his 1837 book The Adventures of Captain Bonneville, which is often considered the best of his three Western books. In the 1840s, he returned to Europe as the American ambassador to Spain.
Irving's grave, marked by a flag, in Sleepy Hollow Cemetery, Sleepy Hollow, New York.
Irving popularized the nickname "Gotham" for New York City, later used in Batman comics and movies, and is credited with inventing the expression "the Almighty dollar." His name also appeared as an alias for forgers in Joseph Heller's classic novel Catch 22 along with its inversion, Irving Washington and that of the author John Milton.
Irving's name appears across the country. The village of Irvington, New York, and the town of Irvington, New Jersey, were named after the author, and also, it is believed, the city of Irving, Texas. Both Washington Street and Irving Street in Birmingham, Alabama, also bear the author's name. His book Bracebridge Hall was the inspiration for the naming of the town of Bracebridge, Ontario. In addition, a library in Los Angeles, California, is named in his honor. Irving Avenue in Port Chester, N.Y., is named after him, as is a condominium townhouse community along this road called Washington Mews, which was built during the 1980s. Washington Irving Memorial Park and Arboretum in Bixby, Oklahoma also bears his name.
In Spain, the room at which he stayed in the Alhambra is labeled and referred to as his room and there is a hotel named for him just outside the Alhambra.
The southern-most section of Lexington Avenue in New York City (between 14th and 20th streets) is named Irving Place, named so after Washington Irving in 1833. A house that stands on the corner of 17th Street and Irving Place is said to have been the one time home of Washington Irving, however that claim seems to have been only a myth. Across the street from this house is the Washington Irving High School (New York City). On the corner of 16th Street and 3rd Avenue (one block east of Irving Place), is the Washington Irving House apartment building.
↑ Christopher Gray, "The Washington Irving House; Why the Legend of Irving Place Is but a Myth," The New York Times, March 13, 1994.
All links retrieved April 22, 2014.


Since the decommissioning of the mobile library in November 2016, Hunters Point, Queens has been without essential public library service. Queens Library at Hunters Point is not slated to open until September 2017, according to an announcement made by Queens Library President, Dennis Walcott at the February Community Board 2 meeting. When the mobile library was decommissioned in November 2016, the community was told the Hunters Point Library would be open imminently. Hunters Point is now expected to be without public library service for at least 11 months, in total.
Another spring and summer without local public library service in Hunters Point is unacceptable. Residents of Hunters Point were promised a public library more than a decade ago. Queens Library must provide mobile library service to the community in the meantime.
We request the immediate reinstatement of book mobile service until Hunters Point Library is fully constructed, staffed, and operational. The Hunters Point community deserves regular, accessible public library resources, which the mobile library has already proven it can provide as a stop-gap measure.
Friends of Court Square Library needs your help with "Queens Library: Return the Mobile Library to Hunters Point, Queens". Join Friends of Court Square Library and 99 supporters today.


text:
Man in hospital with serious head injuries after Sussex robberies
Published: 14:00 Saturday 13 April 2019
Witnesses are being sought after two East Sussex robberies on the same night, which left one man in hospital with serious head injuries.
Sussex Police said the first of the robberies occurred at the bottom of St James's Street in Brighton at around 1am on Sunday (April 7), before a similar incident happened nearby in Stein Street around 3.30am on the same date.
A police spokesman said: "The [first] victim, a man in his 30s, was walking home when he was assault, believed to have been knocked unconscious and had his phone stolen.
"[In the second robbery], two men, one in his 30s and the other in his 40s, were assaulted and their phones were also stolen. One of the victims suffered serious head injuries and was taken to the Royal Sussex County Hospital."
Investigating officer, detective constable Paul Heal said: "These were serious unprovoked attacks on members of the public who had been enjoying a night out.
"We believe the two robberies are linked and are appealing to any member of the public with information to get in contact with us without delay. Did you witnesses either of the assaults?
"We are currently not linking these assaults to any other matters."
Please report information either online or by calling 101 quoting Operation Lacoste.
Sussex murder arrest: Man released on bail as investigation continues into mother-of-two's death


You are here: Home / Coffee and Health / Does Coffee Raise Blood Pressure?
If you suffer from Cardiovascular Disease (CVD or coronary heart disease) and/or fear you might some day due to high blood pressure, is your coffee consumption compounding the problem? Or, are there other things you can do to alleviate your high blood pressure and CVD concerns that do NOT include ending, or severely lessening, your coffee intake? This article explores reliable answers to those questions.
CVD is the number one cause of death in America and high blood pressure is one of its biggest red flags. CVD has been the subject of extensive medical and scientific research for several decades. While researchers have differed in their conclusions over time, new evidence reported in The American Journal of Epidemiology in 1999 strongly indicates that consumption of coffee and caffeine does not contribute to CVD, finding neither caffeinated nor decaffeinated coffee associated with the risk of stroke-even for those drinking more than four cups of coffee a day.
Willet et. al, in a prospective study reported in the February 1996 issue of the Journal of the American Medical Association (JAMA), examined data collected from more than 85,000 women over a 10-year period. After adjusting for known risk factors, the authors found no evidence for any positive association between coffee consumption and risk of CVD for women consuming six or more cups of coffee a day.
A 1990 New England Journal of Medicine study of more than 45,000 men found no link between coffee, caffeine, and CVD for those drinking four or more cups of coffee a day.
These results confirm findings from the earlier Framingham Heart Study of more than 6,000 adults conducted over 20 years (as published in the Archives of Internal Medicine) and two 1987 studies using data from the Honolulu Heart Program (published in The New England Journal of Medicine and The American Journal of Epidemiology respectively).
Despite the previous controversy on the subject, most researchers now conclude that regular coffee and caffeine use has little or no effect on blood pressure.
Studies reviewed in the Progress in Cardiovascular Diseases indicate that while first-time caffeine use may produce immediate, minimal changes in blood pressure, these changes are transient. No changes in blood pressure appear to occur in regular users of caffeine. A 1991 study published in the British Medical Journal reached the same conclusion and indicated that restricting caffeine did not reduce blood pressure in people with mild hypertension. A number of studies that have looked at people with normal blood pressure (published in the Archives of Internal Medicine and the American Journal of Nutrition) have concluded that caffeine does not contribute to hypertension.
I think it's safe to conclude that enough reliable evidence exists that can put to rest the claim that coffee/caffeine contributes to high blood pressure and even CVD.
What's the Better Alternative than Retiring Your Coffee Mug?
As a certified fitness trainer, I've learned that one of the most effective ways to counteract high blood pressure and the onset of CVD is to be physically active, NOT – as the studies above prove – eliminate caffeine consumption. In fact, as my caffeine and fitness article explains, caffeine can even help you become more fit.
An American Heart Association study, as referenced by several peer-reviewed scientific and medical publications, has recently claimed that people who are physically active have a lower risk of getting high blood pressure — 20%-50% lower — than people who are not active.
Besides losing weight, there are other reasons to exercise: Being physically active can reduce your risk for heart disease, help lower your total cholesterol level and raise HDL-cholesterol (the "good" cholesterol that does not build up in the arteries), and help lower high blood pressure. And, again, people who are physically active have a lower risk of getting high blood pressure — 20 to 50 percent lower — than people who are not active.
More vigorous exercise has added benefits. It helps improve the fitness of the heart and lungs. And that, in turn, protects you more against heart disease and high blood pressure. Activities like swimming, brisk walking, running, and jumping rope are called "aerobic." This means that the body uses oxygen to make the energy it needs for the activity. Aerobic activities can condition your heart and lungs if done at the right intensity for 30 minutes, three to four times a week. But if you don't have 30 minutes for a break, try to find two 15-minute periods or even three 10-minute periods. Try to do some type of aerobic activity in the course of a week. And, since stress is also a major CAUSE of high blood pressure, exercise can even help lower stress levels as well.
Most people don't need to see a doctor before they start exercising, since a gradual, sensible exercise program has few health risks. But if you have a health problem like high blood pressure; if you have pains or pressure in the chest or shoulder area; if you tend to feel dizzy or faint; if you get very breathless after a mild workout; or are middle-aged or older and have not been active, and you are planning a vigorous exercise program, you should check with your doctor first. Otherwise, drink your coffee, get out, get active, and get fit — and help prevent high blood pressure and CVD.
Blood Pressure and Coffee – A contrary view on coffee's role on blood pressure.
Matt Pitcher is a certified fitness trainer and entrepreneur.


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Home/App Reviews (page 19)
From the latest games to useful apps that would otherwise fall through the cracks, iOS App Lists publishes app and game reviews on a regular basis.
Our reviews are unbiased, brutally honest, and always to the point. If you're looking for an expert opinion on the latest apps and games, our reviews are definitely worth checking out!
RemindMeAt for iPhone Features Location-Based Reminders and More
January 31, 2015 , 11:49 am App Reviews 0
Sometimes a simple reminder from your to do list just isn't enough. Occasionally you have to remember something specific at a particular location. That's where an app like RemindMeAt comes in handy. This useful productivity app for iPhone lets you create location-based reminders quickly and easily.
Flags Hangman Is a Fun and Educational Game for iPhone and iPad
January 29, 2015 , 5:14 pm App Reviews 0
There are plenty of games to choose from on the App Store, but it's tough to find what you're looking for without getting a bit overwhelmed. Plus, many of these games tend to be a bit mindless or imitations of more popular games. However, Flags Hangman is one game that …
Who? The Game Lets You Interact with Facebook Friends in a Whole New Way
Facebook is usually a decent form of entertainment on its own, but sometimes it's fun to get a little adventurous. Who? the Game for iPhone allows you to connect with friends and play the classic game of Guess Who in a completely different way.
Weekly Schedule – When Time Matters Has Potential, but Falls Short
November 13, 2014 , 12:39 pm App Reviews 0
Weekly Schedule – When Time Matters is intended to be a scheduling app that lets users quickly and easily manage their time. It appears to be geared toward teachers who are looking for a solution to keep track of their schedule.
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The LawBytes Podcast, Episode 17: What To Do About Huawei? - Christopher Parsons Unpacks One of Canada's Most Challenging Policy Issues - Michael Geist
What to do about Huawei? The Chinese telecom giant has emerged as one of Canada's most challenging policy issues, raising concerns involving competition, communications, security, and trade not to mention kidnappings and arrests of corporate personnel. The government has repeatedly promised to articulate a policy on the use of Huawei equipment in Canada's next generation wireless networks only to regularly delay doing so. Dr. Christopher Parsons, a senior research associate at the Citizen Lab, the world-famous cyber-security lab located at the Munk School of Global Affairs and Public Policy at the University of Toronto, joins the podcast to help sort through fact from fiction when it comes to Huawei.


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A response to Sherman Cymru: What is the purpose of theatre?
This post is motivated by an evening at Sherman Cymru. The theatre welcomed new writers as part of its TAITH project. Three performances responding to the theme of social uprising were brought to the stage, with discussion and feedback.
Do I think it's the responsibility of theatre to create revolution?
I think theatre is at its best when it creates a dialogue.
It is a wonderful intermediary, a stimulus.
Enabling thoughts on matters not necessarily faced if not for the stage.
Enabling an understanding, of acceptance, revolution, whatever floats an individual's boat.
To stimulate our thought process.
Iphigenia in Splott was amazingly successful at this. The wealth of responses demonstrating its reach and impact.
Sherman Cymru enabled a conversation, that those in the audience will have with a colleague at work, on a train, at the gym, with another parent on the school run, with a friend over a glass of wine.
It may not happen within the theatre, but people will remember, it will chime, it may not be immediate, but given the themes of the play, it's quite likely it will chime in the near future.
The election, made the conversation real. It made people realise the bubbles which we exist within. That we have done it to protect our family, but in protecting our family we stopped talking, our community weakened. And by not talking, stimulating the conversation, we didn't appreciate the breadth of public opinion. And that's ok, we weren't alone, no-one expected a majority government ergo no-one appreciated the volume of those voting Conservative… or those forgoing their vote.
Is theatre only for the middle class?
Aarrrghhh. Welcome to sector wars. The same way construction is the career for under achievers. Because the theatre which lives and breathes your creativity is encased in the design and build of amateurs?
Every sector is competing for the best talent. It's not that it's about the middle class.
But it will be, of course, if you allow it to happen, because if a career is not offering beyond the living wage it is restricting its talent pipeline.
So, garner support for the living wage across the board.
Enable each sector to be competitive so individuals can choose to access careers where their talents lie. The holy grail.
But do not compromise talent, it is worth paying for.
And what of attracting an audience?
Please do not compromise your value.
The projects the Sherman enables, Sherman5, the Christmas project, these are gold dust and should be promoted to allow other communities to benefit from their local theatre.
Support, experience and encourage theatres bringing Room on a Broom, Octonauts and Hetty Feathers to the stage. It gets people into the theatre. It enables a child's first theatre experience. Of course it's a commercial dream. But it does create familiarity with theatre.
Because then it can be about the next theatre ticket purchase.
And getting the adult to the theatre without their charge, and to see something which interests them.
Beyond tv and into the imagination.
The rambling conclusion
Which brings me to my final point.
Sorry for interrupting to disagree.
But as obstinate child who never learned social triggers, I just needed to say.
Take Iphigenia in Splott to the masses.
Create the dialogue.
Give people the confidence of their voice.
Give people the confidence to make a difference.
And make it tangible to them.
Please consider making it about their community.
Taking it beyond empathy and association to a person's reality.
Because nothing scares a person more than unwelcomed change.
A redundancy. A cut to public services. A library closure.
Immediacy creates uprising.
Dementia, redundancy, racism…. "it happened to me , I will fight it."
Theatre creates the environment,
The individual pursues the dialogue.
It may not remain pure to the text.
But Iphigenia in Splott has created the dialogue. It opened doors.
And hopefully, beyond my immediate circles, it has instigated conversation, created change at the grassroots.
Because that's what happened as a result of the election.
People realised their neighbour voted Conservative.
We realised those within our community didn't bother voting because their vote wouldn't matter.
The assumption that living within a stronghold meant one vote wouldn't matter.
Because the contradictory messages made it too difficult to understand which party to vote for.
Because no party appealed to immediate priorities (and the impact of the manifesto of the party which would win didn't feel real).
Because being engaged isn't possible, the people standing are too far removed from life.
Iphigenia in Splott sparked the conversation.
What the arts achieves in addition to 'entertaining'.
And when you spark these conversations.
And invite them, and nurture them through 'Taith'.
You prove you can celebrate what you do well.
So, yes, I disagree.
Iphigenia in Splott is a huge success. And it can and will be a success nation (whether that be Wales, GB, or UK) wide.
Yes, it will resonate, it will allow audiences to associate.
But, I cannot stray from my conviction, that to know this is happening on your doorstep, in Wythenshawe; Burnley; Chalvey; Luton; bringing it home, creates the incentive for change. The immediacy.
To have a script with points of reference personal to you increases the feeling of intimacy, and relevance.
Nothing is worse, than the crime on your doorstep, your library closing, being declined a place at your local school, the recipient of discrimination.
And yes, you could get local writers involved. But this is something you created, something amazing which the talent of the Sherman fused. That quality needs to find its way to all communities, and shouldn't be weakened through franchise.
Theatre can create sympathy and empathy. It can create humour, it can shock.
But now, more than ever, it can create an understanding of the alternative, the realities of sitting on hands, making people open their eyes to what is happening in their community and creating a momentum for change.
Theatre can create change.
Days out in Wales: Oxwich Castle
My theatre favourites for 2018
Tree Fu Tom Live
The Curious Incident of the Dog in the Night Time


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Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction
Michael Gertz, J. Brian Houston, Aleksandra Galetin
Prediction of intestinal availability (F G), in conjunction with hepatic metabolism, is of considerable importance in drug disposition to assess oral clearance and liability to drug-drug interactions. In the current study, F G predictions were performed within a physiologically based pharmacokinetic (PBPK) model using in vitro permeability and clearance data. The prediction success was assessed in comparison with the Q Gut model. In addition, apparent oral clearance values, predicted using the PBPK model, were compared with in vivo observations from meta-analyses. Finally, unbound intrinsic clearance values (CLu int) were determined for 12 CYP3A substrates in eight individual human jejunal microsome (HJM) samples to assess interindividual variability in intestinal intrinsic clearance and subsequent F G predictions. Overall, the PBPK model improved FG predictions in comparison with the Q Gut model; this was apparent by a reduced bias and increased precision. In particular, F G predictions of indinavir, saquinavir, and terfenadine were modeldependent. The predicted oral clearance values of the drugs investigated ranged from 8.79 to 6320 l/h for tacrolimus and simvastatin, respectively, and were overall within 3-fold of the observed data with the exception of indinavir, atorvastatin, and buspirone. The individual HJM CLu int values ranged from 17 to 14,000 μl·min -1·mg -1 for atorvastatin and saquinavir, respectively, and corresponding interindividual variability in CLu int estimates ranged from 41 to 67%. These in vitro data resulted in predicted F G values ranging from 0.03 to 0.94 for simvastatin and indinavir, respectively. The largest interindividual variability of F G was predicted for terfenadine (65%) in contrast with the low variability in the case of indinavir (3%). Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics.
https://doi.org/10.1124/dmd.111.039248
10.1124/dmd.111.039248
http://dmd.aspetjournals.org/content/39/9/1633.full.pdf+html
Dive into the research topics of 'Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction'. Together they form a unique fingerprint.
Indinavir Pharmacology, Toxicology and Pharmaceutical Science 100%
Pharmacokinetics Pharmacology, Toxicology and Pharmaceutical Science 75%
Drug Pharmacology, Toxicology and Pharmaceutical Science 50%
CYP3A Pharmacology, Toxicology and Pharmaceutical Science 50%
Atorvastatin Pharmacology, Toxicology and Pharmaceutical Science 50%
Simvastatin Pharmacology, Toxicology and Pharmaceutical Science 50%
Saquinavir Pharmacology, Toxicology and Pharmaceutical Science 50%
Terfenadine Pharmacology, Toxicology and Pharmaceutical Science 50%
Gertz, M., Houston, J. B., & Galetin, A. (2011). Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction. Drug Metabolism and Disposition, 39(9), 1633-1642. https://doi.org/10.1124/dmd.111.039248
Gertz, Michael ; Houston, J. Brian ; Galetin, Aleksandra. / Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction. In: Drug Metabolism and Disposition. 2011 ; Vol. 39, No. 9. pp. 1633-1642.
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title = "Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction",
abstract = "Prediction of intestinal availability (F G), in conjunction with hepatic metabolism, is of considerable importance in drug disposition to assess oral clearance and liability to drug-drug interactions. In the current study, F G predictions were performed within a physiologically based pharmacokinetic (PBPK) model using in vitro permeability and clearance data. The prediction success was assessed in comparison with the Q Gut model. In addition, apparent oral clearance values, predicted using the PBPK model, were compared with in vivo observations from meta-analyses. Finally, unbound intrinsic clearance values (CLu int) were determined for 12 CYP3A substrates in eight individual human jejunal microsome (HJM) samples to assess interindividual variability in intestinal intrinsic clearance and subsequent F G predictions. Overall, the PBPK model improved FG predictions in comparison with the Q Gut model; this was apparent by a reduced bias and increased precision. In particular, F G predictions of indinavir, saquinavir, and terfenadine were modeldependent. The predicted oral clearance values of the drugs investigated ranged from 8.79 to 6320 l/h for tacrolimus and simvastatin, respectively, and were overall within 3-fold of the observed data with the exception of indinavir, atorvastatin, and buspirone. The individual HJM CLu int values ranged from 17 to 14,000 μl·min -1·mg -1 for atorvastatin and saquinavir, respectively, and corresponding interindividual variability in CLu int estimates ranged from 41 to 67%. These in vitro data resulted in predicted F G values ranging from 0.03 to 0.94 for simvastatin and indinavir, respectively. The largest interindividual variability of F G was predicted for terfenadine (65%) in contrast with the low variability in the case of indinavir (3%). Copyright {\textcopyright} 2011 by The American Society for Pharmacology and Experimental Therapeutics.",
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Gertz, M, Houston, JB & Galetin, A 2011, 'Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction', Drug Metabolism and Disposition, vol. 39, no. 9, pp. 1633-1642. https://doi.org/10.1124/dmd.111.039248
Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction. / Gertz, Michael; Houston, J. Brian; Galetin, Aleksandra.
In: Drug Metabolism and Disposition, Vol. 39, No. 9, 09.2011, p. 1633-1642.
T1 - Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction
AU - Gertz, Michael
AU - Houston, J. Brian
AU - Galetin, Aleksandra
N2 - Prediction of intestinal availability (F G), in conjunction with hepatic metabolism, is of considerable importance in drug disposition to assess oral clearance and liability to drug-drug interactions. In the current study, F G predictions were performed within a physiologically based pharmacokinetic (PBPK) model using in vitro permeability and clearance data. The prediction success was assessed in comparison with the Q Gut model. In addition, apparent oral clearance values, predicted using the PBPK model, were compared with in vivo observations from meta-analyses. Finally, unbound intrinsic clearance values (CLu int) were determined for 12 CYP3A substrates in eight individual human jejunal microsome (HJM) samples to assess interindividual variability in intestinal intrinsic clearance and subsequent F G predictions. Overall, the PBPK model improved FG predictions in comparison with the Q Gut model; this was apparent by a reduced bias and increased precision. In particular, F G predictions of indinavir, saquinavir, and terfenadine were modeldependent. The predicted oral clearance values of the drugs investigated ranged from 8.79 to 6320 l/h for tacrolimus and simvastatin, respectively, and were overall within 3-fold of the observed data with the exception of indinavir, atorvastatin, and buspirone. The individual HJM CLu int values ranged from 17 to 14,000 μl·min -1·mg -1 for atorvastatin and saquinavir, respectively, and corresponding interindividual variability in CLu int estimates ranged from 41 to 67%. These in vitro data resulted in predicted F G values ranging from 0.03 to 0.94 for simvastatin and indinavir, respectively. The largest interindividual variability of F G was predicted for terfenadine (65%) in contrast with the low variability in the case of indinavir (3%). Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics.
AB - Prediction of intestinal availability (F G), in conjunction with hepatic metabolism, is of considerable importance in drug disposition to assess oral clearance and liability to drug-drug interactions. In the current study, F G predictions were performed within a physiologically based pharmacokinetic (PBPK) model using in vitro permeability and clearance data. The prediction success was assessed in comparison with the Q Gut model. In addition, apparent oral clearance values, predicted using the PBPK model, were compared with in vivo observations from meta-analyses. Finally, unbound intrinsic clearance values (CLu int) were determined for 12 CYP3A substrates in eight individual human jejunal microsome (HJM) samples to assess interindividual variability in intestinal intrinsic clearance and subsequent F G predictions. Overall, the PBPK model improved FG predictions in comparison with the Q Gut model; this was apparent by a reduced bias and increased precision. In particular, F G predictions of indinavir, saquinavir, and terfenadine were modeldependent. The predicted oral clearance values of the drugs investigated ranged from 8.79 to 6320 l/h for tacrolimus and simvastatin, respectively, and were overall within 3-fold of the observed data with the exception of indinavir, atorvastatin, and buspirone. The individual HJM CLu int values ranged from 17 to 14,000 μl·min -1·mg -1 for atorvastatin and saquinavir, respectively, and corresponding interindividual variability in CLu int estimates ranged from 41 to 67%. These in vitro data resulted in predicted F G values ranging from 0.03 to 0.94 for simvastatin and indinavir, respectively. The largest interindividual variability of F G was predicted for terfenadine (65%) in contrast with the low variability in the case of indinavir (3%). Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics.
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Gertz M, Houston JB, Galetin A. Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction. Drug Metabolism and Disposition. 2011 Sep;39(9):1633-1642. doi: 10.1124/dmd.111.039248


Beer battered onion rings served with our chipotle garlic dipping sauce.
Fried wisconsin cheese curds served with ranch dipping sauce.
Homemade chili topped with red onion, cheddar, jack cheese and sour cream. Served with tricolor tortilla chips for dipping.


Jule Niles who is the mother of Arsenal star Ainsley Maitland-Niles has cried out bitterly that she is currently living in frustration and pains and her son has refused to help her.
She is presently sleeping in freezing 10ft square metal storage crate, while her son who earns £30,000-a-week at Arsenal lives in luxury £700,000 flat.
Jule said she began living in the box three months ago after her relationship broke down with Ainsley, 20, who is rated at £15 million.
The 38-year-old explained that she has been forgotten by her son since he started earning big money at Arsenal.
"The money's gone to his head as I live in a metal container with no windows or carpet. There is no toilet or washing facilities.
"My son Ainsley could buy me a flat with two weeks or two month's wages, but the money's gone to his head and I'm in this position.
"My son plays for Arsenal and I am homeless in a storage unit.
"It's not a home. I know what home feels like — to be able to shower, brush your teeth and sit in your room.
"All that I miss, but most of all I miss my family. It's horrible. I just want to know what I've done wrong." Jule Niles explained according to UK Sun.
Jule sat on a bare mattress on the container's floor and told how she struggled as a single mum to raise Ainsley and charity worker Cordi in council houses in and around Ilford, East London.
All around her are bags of family photos, including dog-eared pictures of Ainsley playing football as a toddler.
Ainsley on the other hand was spotted by Arsenal scouts and signed for the club's academy when he was six.
And all the sacrifices of her mother appeared to have paid off when in December 2014 he made his debut for the Gunners aged 17 in the Champions League against Galatasaray.
Four days later he made his Premier League debut in a 4-1 victory over Newcastle United.
He currently lives in a new development in upmarket Finchley, North London, while his mother is homeless.


If you think that you can be the next top Emo star, this game is for you. Crazy hairdo, purple skin and other punk options are the main highlights of this exciting dress up game. You probably need to think beyond the regular style while playing this game.


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Randy Johnson's Top 5 Arizona Diamondbacks' Moments
Champions. Credit: arizona.diamondbacks.mlb.com
In terms of overall, competitive games, the 2001 World Series was ordinary with Arizona winning three of their contests by four or more runs, two of them by double digits. In terms of drama, few Fall Classics could match up with this one. There was the backdrop of 9/11. You had the Yankees on the brink of consecutive losses only to come back and win both games. You had New York trying to become the first team since their 1950's ancestors to win four straight World Series. Throw in only the third Game 7 matchup in the span of 14 years, and you have one of the most memorable affairs of all time.
Johnson, who had thrown 104 pitches in seven innings the day before, was asked to keep New York at bay with two outs in the top of the eighth inning. Watching him come out of the bullpen was, to a Yankees' fan, eerily similar to that scene six years earlier in Seattle. The script went the same way for the Bronx Bombers only this time with the highest of stakes. Unit retired all four batters he faced and then watched as the Snakes solved the greatest of them all, Mariano Rivera. I don't think I need to tell you the scene at Bank One Ballpark in the aftermath of the biggest win in franchise history. For Randy Johnson, that relief stint may not have been the biggest personal highlight. However, to a D'backs' fan, there was no bigger Big Unit moment than those bullpen doors swinging open.
Next: Arizona Diamondbacks: Reviewing 2014's Trade Deadline Deals


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In a city of 9 million people, we make the Big Apple feel like a small community. We envision our school as a learning community that treats children and adults with respect and kindness. Our motto is, "Take Care of Each Other". We want children to value diversity of ideas, to develop compassion and the ability to see themselves in another's shoes. Along with our dedicated teaching staff, rigorous curriculum, and supportive parent body, 183 offers unique programming to enrich each child's elementary school experience.
At 183, each grade has enrichment programs that not only deepen particular subjects studied throughout the year, but help students discover passions and talents. We offer instrumental and vocal studies in grades 3-5, and partnerships with the following New York City cultural institutions: One World Global Classroom, New York Historical Society, Justice Resource Center, NYC Chess, NYC Ballet, and National Dance Institute. Our school also offers students the chance to join our competitive Math League and Track Team.
Through funding from our City Councilmember Ben Kallos, PS 183 opened their new Hydroponics Science lab in the fall of 2019. With a partnership with New York Sunworks, students, in addition to the New York Science curriculum, will study environmental sustainability by growing their own plants and vegetables.
Hydroponics Science Lab
Thanks to a grant from our NY State Assemblywoman Rebecca Seawright, P.S. 183 recently renovated their art room. Students get art class, once a week, where they work in a variety of mediums. Student art work is featured in our yearly 183 art show and the District 2 Art Show at Sotheby's Auction House.
Our PTA is committed to funding teaching assistants to support our lower grade classroom teachers. Our Teaching Assistants help our young students at specials, in the classroom, and during lunch and recess.
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419 East 66th St, New York, NY 10065
info@ps183.org


The beauty of this work from Porto's great architect, Marques da Silva, is in every corner and detail. Run-down and battered, like so many public buildings in the age of austerity, but fully functioning, the massive Liceu Alexandre Herculano has nonetheless survived (for now) the madness of Parque Escolar, which has contributed so much to the destruction of our Architectural Heritage (and public finances) in the name of trendy grandiose words like Modernisation, Sustainability and a brand new (really from the 1960s) "conceptual model".
Griping aside, as with any competent Beaux-Arts project every part is articulated and differentiated in character and detail. The modest back elevation faces the open-air sports field with the remnants of Porto's industries as a backdrop. The inner courtyards (there are three) feature an endless parade of Architectural inventions: colonnades with open passages above, a myriad of different door and window sizes, muntins and mullions, balconies, terraces, pediments. Hierarchy, symmetry and detail combined to the maximum artistic effect and grace, as opposed to the interesting-but-dull classical examples which would come from the Fascists a few decades later. This was the apex of Portuguese Architecture and fortunately for us we can still enjoy it almost a century later – the cornerstone was laid in 1916.
PS: you can consult the planned intervention for the School here. For some reason it hasn't been carried out yet.