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Over 3 years (145)
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Recruitment, Readiness, and Retention of Providers at a Field Hospital during the Pandemic
Ishaan Gupta, Zishan K. Siddiqui, Mark D. Phillips, Amteshwar Singh, Shaker M. Eid, Flora Kisuule, James R. Ficke, CONQUER COVID Consortium, Melinda E. Kantsiper
Journal: Disaster Medicine and Public Health Preparedness / Accepted manuscript
Published online by Cambridge University Press: 10 January 2022, pp. 1-21
In response to the coronavirus disease 2019 (COVID-19) pandemic, the State of Maryland established a 250-bed emergency response field hospital at the Baltimore Convention Center to support the existing healthcare infrastructure. To operationalize this hospital with 65 full-time equivalent (FTE) clinicians in less than four weeks, more than 300 applications were reviewed, 186 candidates were interviewed, and 159 clinicians were credentialed and onboarded. The key steps to achieve this undertaking involved employing multidisciplinary teams with experienced personnel, mass outreach, streamlined candidate tracking, pre-interview screening, utilizing all available expertise, expedited credentialing, and focused onboarding. To ensure staff preparedness, the leadership developed innovative team models, applied principles of effective team building, and provided 'just in time' training on COVID-19 and non-COVID-19 related topics to the staff. The leadership focused on staff safety and well-being, offered appropriate financial remuneration and provided leadership opportunities that allowed retention of staff.
The ASKAP Variables and Slow Transients (VAST) Pilot Survey
Tara Murphy, David L. Kaplan, Adam J. Stewart, Andrew O'Brien, Emil Lenc, Sergio Pintaldi, Joshua Pritchard, Dougal Dobie, Archibald Fox, James K. Leung, Tao An, Martin E. Bell, Jess W. Broderick, Shami Chatterjee, Shi Dai, Daniele d'Antonio, Gerry Doyle, B. M. Gaensler, George Heald, Assaf Horesh, Megan L. Jones, David McConnell, Vanessa A. Moss, Wasim Raja, Gavin Ramsay, Stuart Ryder, Elaine M. Sadler, Gregory R. Sivakoff, Yuanming Wang, Ziteng Wang, Michael S. Wheatland, Matthew Whiting, James R. Allison, C. S. Anderson, Lewis Ball, K. Bannister, D. C.-J. Bock, R. Bolton, J. D. Bunton, R. Chekkala, A. P Chippendale, F. R. Cooray, N. Gupta, D. B. Hayman, K. Jeganathan, B. Koribalski, K. Lee-Waddell, Elizabeth K. Mahony, J. Marvil, N. M. McClure-Griffiths, P. Mirtschin, A. Ng, S. Pearce, C. Phillips, M. A. Voronkov
Journal: Publications of the Astronomical Society of Australia / Volume 38 / 2021
Published online by Cambridge University Press: 12 October 2021, e054
The Variables and Slow Transients Survey (VAST) on the Australian Square Kilometre Array Pathfinder (ASKAP) is designed to detect highly variable and transient radio sources on timescales from 5 s to $\sim\!5$ yr. In this paper, we present the survey description, observation strategy and initial results from the VAST Phase I Pilot Survey. This pilot survey consists of $\sim\!162$ h of observations conducted at a central frequency of 888 MHz between 2019 August and 2020 August, with a typical rms sensitivity of $0.24\ \mathrm{mJy\ beam}^{-1}$ and angular resolution of $12-20$ arcseconds. There are 113 fields, each of which was observed for 12 min integration time, with between 5 and 13 repeats, with cadences between 1 day and 8 months. The total area of the pilot survey footprint is 5 131 square degrees, covering six distinct regions of the sky. An initial search of two of these regions, totalling 1 646 square degrees, revealed 28 highly variable and/or transient sources. Seven of these are known pulsars, including the millisecond pulsar J2039–5617. Another seven are stars, four of which have no previously reported radio detection (SCR J0533–4257, LEHPM 2-783, UCAC3 89–412162 and 2MASS J22414436–6119311). Of the remaining 14 sources, two are active galactic nuclei, six are associated with galaxies and the other six have no multi-wavelength counterparts and are yet to be identified.
The Evolutionary Map of the Universe pilot survey
Ray P. Norris, Joshua Marvil, J. D. Collier, Anna D. Kapińska, Andrew N. O'Brien, L. Rudnick, Heinz Andernach, Jacobo Asorey, Michael J. I. Brown, Marcus Brüggen, Evan Crawford, Jayanne English, Syed Faisal ur Rahman, Miroslav D. Filipović, Yjan Gordon, Gülay Gürkan, Catherine Hale, Andrew M. Hopkins, Minh T. Huynh, Kim HyeongHan, M. James Jee, Bärbel S. Koribalski, Emil Lenc, Kieran Luken, David Parkinson, Isabella Prandoni, Wasim Raja, Thomas H. Reiprich, Christopher J. Riseley, Stanislav S. Shabala, Jaimie R. Sheil, Tessa Vernstrom, Matthew T. Whiting, James R. Allison, C. S. Anderson, Lewis Ball, Martin Bell, John Bunton, T. J. Galvin, Neeraj Gupta, Aidan Hotan, Colin Jacka, Peter J. Macgregor, Elizabeth K. Mahony, Umberto Maio, Vanessa Moss, M. Pandey-Pommier, Maxim A. Voronkov
Published online by Cambridge University Press: 07 September 2021, e046
We present the data and initial results from the first pilot survey of the Evolutionary Map of the Universe (EMU), observed at 944 MHz with the Australian Square Kilometre Array Pathfinder (ASKAP) telescope. The survey covers $270 \,\mathrm{deg}^2$ of an area covered by the Dark Energy Survey, reaching a depth of 25–30 $\mu\mathrm{Jy\ beam}^{-1}$ rms at a spatial resolution of $\sim$ 11–18 arcsec, resulting in a catalogue of $\sim$ 220 000 sources, of which $\sim$ 180 000 are single-component sources. Here we present the catalogue of single-component sources, together with (where available) optical and infrared cross-identifications, classifications, and redshifts. This survey explores a new region of parameter space compared to previous surveys. Specifically, the EMU Pilot Survey has a high density of sources, and also a high sensitivity to low surface brightness emission. These properties result in the detection of types of sources that were rarely seen in or absent from previous surveys. We present some of these new results here.
The MAGPI survey: Science goals, design, observing strategy, early results and theoretical framework
C. Foster, J. T. Mendel, C. D. P. Lagos, E. Wisnioski, T. Yuan, F. D'Eugenio, T. M. Barone, K. E. Harborne, S. P. Vaughan, F. Schulze, R.-S. Remus, A. Gupta, F. Collacchioni, D. J. Khim, P. Taylor, R. Bassett, S. M. Croom, R. M. McDermid, A. Poci, A. J. Battisti, J. Bland-Hawthorn, S. Bellstedt, M. Colless, L. J. M. Davies, C. Derkenne, S. Driver, A. Ferré-Mateu, D. B. Fisher, E. Gjergo, E. J. Johnston, A. Khalid, C. Kobayashi, S. Oh, Y. Peng, A. S. G. Robotham, P. Sharda, S. M. Sweet, E. N. Taylor, K.-V. H. Tran, J. W. Trayford, J. van de Sande, S. K. Yi, L. Zanisi
Published online by Cambridge University Press: 26 July 2021, e031
We present an overview of the Middle Ages Galaxy Properties with Integral Field Spectroscopy (MAGPI) survey, a Large Program on the European Southern Observatory Very Large Telescope. MAGPI is designed to study the physical drivers of galaxy transformation at a lookback time of 3–4 Gyr, during which the dynamical, morphological, and chemical properties of galaxies are predicted to evolve significantly. The survey uses new medium-deep adaptive optics aided Multi-Unit Spectroscopic Explorer (MUSE) observations of fields selected from the Galaxy and Mass Assembly (GAMA) survey, providing a wealth of publicly available ancillary multi-wavelength data. With these data, MAGPI will map the kinematic and chemical properties of stars and ionised gas for a sample of 60 massive ( ${>}7 \times 10^{10} {\mathrm{M}}_\odot$ ) central galaxies at $0.25 < z <0.35$ in a representative range of environments (isolated, groups and clusters). The spatial resolution delivered by MUSE with Ground Layer Adaptive Optics ( $0.6-0.8$ arcsec FWHM) will facilitate a direct comparison with Integral Field Spectroscopy surveys of the nearby Universe, such as SAMI and MaNGA, and at higher redshifts using adaptive optics, for example, SINS. In addition to the primary (central) galaxy sample, MAGPI will deliver resolved and unresolved spectra for as many as 150 satellite galaxies at $0.25 < z <0.35$ , as well as hundreds of emission-line sources at $z < 6$ . This paper outlines the science goals, survey design, and observing strategy of MAGPI. We also present a first look at the MAGPI data, and the theoretical framework to which MAGPI data will be compared using the current generation of cosmological hydrodynamical simulations including EAGLE, Magneticum, HORIZON-AGN, and Illustris-TNG. Our results show that cosmological hydrodynamical simulations make discrepant predictions in the spatially resolved properties of galaxies at $z\approx 0.3$ . MAGPI observations will place new constraints and allow for tangible improvements in galaxy formation theory.
Mastoid cavity obliteration using bone pâté versus bioactive glass granules in the management of chronic otitis media (squamous disease): a prospective comparative study
A K Mishra, A Mallick, J R Galagali, A Gupta, A Sethi, A Ghotra
Journal: The Journal of Laryngology & Otology / Volume 135 / Issue 6 / June 2021
To compare the efficacy of bone pâté versus bioactive glass in mastoid obliteration.
This randomised parallel groups study was conducted at a tertiary care centre between September 2017 and August 2019. Sixty-eight patients, 33 males and 35 females, aged 12–56 years, randomly underwent single-stage canal wall down mastoidectomy with mastoid obliteration using either bone pâté (n = 35) or bioactive glass (n = 33), and were evaluated 12 months after the operation.
A dry epithelised cavity (Merchant's grade 0 or 1) was achieved in 65 patients (95.59 per cent). Three patients (4.41 per cent) showed recidivism. The mean air–bone gap decreased to 16.80 ± 4.23 dB from 35.10 ± 5.21 dB pre-operatively. The mean Glasgow Benefit Inventory score was 30.02 ± 8.23. There was no significant difference between the two groups in these outcomes. However, the duration of surgery was shorter in the bioactive glass group (156.87 ± 7.83 vs 162.28 ± 8.74 minutes; p = 0.01).
The efficacy of both materials was comparable.
Clinical Study of 668 Indian Subjects with Juvenile, Young, and Early Onset Parkinson's Disease
Prashanth L. Kukkle, Vinay Goyal, Thenral S. Geetha, Kandadai R. Mridula, Hrishikesh Kumar, Rupam Borgohain, Adreesh Mukherjee, Pettarusp M. Wadia, Ravi Yadav, Soaham Desai, Niraj Kumar, Ravi Gupta, Atanu Biswas, Pramod K. Pal, Uday Muthane, Shymal K. Das, Niall Quinn, Vedam L. Ramprasad, the Parkinson Research Alliance of India (PRAI)
Journal: Canadian Journal of Neurological Sciences / Volume 49 / Issue 1 / January 2022
Published online by Cambridge University Press: 09 March 2021, pp. 93-101
Print publication: January 2022
To determine the demographic pattern of juvenile-onset parkinsonism (JP, <20 years), young-onset (YOPD, 20–40 years), and early onset (EOPD, 40–50 years) Parkinson's disease (PD) in India.
Materials and Methods:
We conducted a 2-year, pan-India, multicenter collaborative study to analyze clinical patterns of JP, YOPD, and EOPD. All patients under follow-up of movement disorders specialists and meeting United Kingdom (UK) Brain Bank criteria for PD were included.
A total of 668 subjects (M:F 455:213) were recruited with a mean age at onset of 38.7 ± 8.1 years. The mean duration of symptoms at the time of study was 8 ± 6 years. Fifteen percent had a family history of PD and 13% had consanguinity. JP had the highest consanguinity rate (53%). YOPD and JP cases had a higher prevalence of consanguinity, dystonia, and gait and balance issues compared to those with EOPD. In relation to nonmotor symptoms, panic attacks and depression were more common in YOPD and sleep-related issues more common in EOPD subjects. Overall, dyskinesias were documented in 32.8%. YOPD subjects had a higher frequency of dyskinesia than EOPD subjects (39.9% vs. 25.5%), but they were first noted later in the disease course (5.7 vs. 4.4 years).
This large cohort shows differing clinical patterns in JP, YOPD, and EOPD cases. We propose that cutoffs of <20, <40, and <50 years should preferably be used to define JP, YOPD, and EOPD.
Australian square kilometre array pathfinder: I. system description
A. W. Hotan, J. D. Bunton, A. P. Chippendale, M. Whiting, J. Tuthill, V. A. Moss, D. McConnell, S. W. Amy, M. T. Huynh, J. R. Allison, C. S. Anderson, K. W. Bannister, E. Bastholm, R. Beresford, D. C.-J. Bock, R. Bolton, J. M. Chapman, K. Chow, J. D. Collier, F. R. Cooray, T. J. Cornwell, P. J. Diamond, P. G. Edwards, I. J. Feain, T. M. O. Franzen, D. George, N. Gupta, G. A. Hampson, L. Harvey-Smith, D. B. Hayman, I. Heywood, C. Jacka, C. A. Jackson, S. Jackson, K. Jeganathan, S. Johnston, M. Kesteven, D. Kleiner, B. S. Koribalski, K. Lee-Waddell, E. Lenc, E. S. Lensson, S. Mackay, E. K. Mahony, N. M. McClure-Griffiths, R. McConigley, P. Mirtschin, A. K. Ng, R. P. Norris, S. E. Pearce, C. Phillips, M. A. Pilawa, W. Raja, J. E. Reynolds, P. Roberts, D. N. Roxby, E. M. Sadler, M. Shields, A. E. T. Schinckel, P. Serra, R. D. Shaw, T. Sweetnam, E. R. Troup, A. Tzioumis, M. A. Voronkov, T. Westmeier
Published online by Cambridge University Press: 05 March 2021, e009
In this paper, we describe the system design and capabilities of the Australian Square Kilometre Array Pathfinder (ASKAP) radio telescope at the conclusion of its construction project and commencement of science operations. ASKAP is one of the first radio telescopes to deploy phased array feed (PAF) technology on a large scale, giving it an instantaneous field of view that covers $31\,\textrm{deg}^{2}$ at $800\,\textrm{MHz}$. As a two-dimensional array of 36 $\times$12 m antennas, with baselines ranging from 22 m to 6 km, ASKAP also has excellent snapshot imaging capability and 10 arcsec resolution. This, combined with 288 MHz of instantaneous bandwidth and a unique third axis of rotation on each antenna, gives ASKAP the capability to create high dynamic range images of large sky areas very quickly. It is an excellent telescope for surveys between 700 and $1800\,\textrm{MHz}$ and is expected to facilitate great advances in our understanding of galaxy formation, cosmology, and radio transients while opening new parameter space for discovery of the unknown.
Cross cultural and global uses of a digital mental health app: results of focus groups with clinicians, patients and family members in India and the United States
Elena Rodriguez-Villa, Abhijit R. Rozatkar, Mohit Kumar, Vikram Patel, Ameya Bondre, Shalini S. Naik, Siddharth Dutt, Urvakhsh M. Mehta, Srilakshmi Nagendra, Deepak Tugnawat, Ritu Shrivastava, Harikeerthan Raghuram, Azaz Khan, John A. Naslund, Snehil Gupta, Anant Bhan, Jagadisha Thirthall, Prabhat K. Chand, Tanvi Lakhtakia, Matcheri Keshavan, John Torous
Journal: Global Mental Health / Volume 8 / 2021
Published online by Cambridge University Press: 24 August 2021, e30
Despite significant advancements in healthcare technology, digital health solutions – especially those for serious mental illnesses – continue to fall short of their potential across both clinical practice and efficacy. The utility and impact of medicine, including digital medicine, hinges on relationships, trust, and engagement, particularly in the field of mental health. This paper details results from Phase 1 of a two-part study that seeks to engage people with schizophrenia, their family members, and clinicians in co-designing a digital mental health platform for use across different cultures and contexts in the United States and India.
Each site interviewed a mix of clinicians, patients, and their family members in focus groups (n = 20) of two to six participants. Open-ended questions and discussions inquired about their own smartphone use and, after a demonstration of the mindLAMP platform, specific feedback on the app's utility, design, and functionality.
Our results based on thematic analysis indicate three common themes: increased use and interest in technology during coronavirus disease 2019 (COVID-19), concerns over how data are used and shared, and a desire for concurrent human interaction to support app engagement.
People with schizophrenia, their family members, and clinicians are open to integrating technology into treatment to better understand their condition and help inform treatment. However, app engagement is dependent on technology that is complementary – not substitutive – of therapeutic care from a clinician.
The Rapid ASKAP Continuum Survey I: Design and first results
Australian SKA Pathfinder
D. McConnell, C. L. Hale, E. Lenc, J. K. Banfield, George Heald, A. W. Hotan, James K. Leung, Vanessa A. Moss, Tara Murphy, Andrew O'Brien, Joshua Pritchard, Wasim Raja, Elaine M. Sadler, Adam Stewart, Alec J. M. Thomson, M. Whiting, James R. Allison, S. W. Amy, C. Anderson, Lewis Ball, Keith W. Bannister, Martin Bell, Douglas C.-J. Bock, Russ Bolton, J. D. Bunton, A. P. Chippendale, J. D. Collier, F. R. Cooray, T. J. Cornwell, P. J. Diamond, P. G. Edwards, N. Gupta, Douglas B. Hayman, Ian Heywood, C. A. Jackson, Bärbel S. Koribalski, Karen Lee-Waddell, N. M. McClure-Griffiths, Alan Ng, Ray P. Norris, Chris Phillips, John E. Reynolds, Daniel N. Roxby, Antony E. T. Schinckel, Matt Shields, Chenoa Tremblay, A. Tzioumis, M. A. Voronkov, Tobias Westmeier
Published online by Cambridge University Press: 30 November 2020, e048
The Rapid ASKAP Continuum Survey (RACS) is the first large-area survey to be conducted with the full 36-antenna Australian Square Kilometre Array Pathfinder (ASKAP) telescope. RACS will provide a shallow model of the ASKAP sky that will aid the calibration of future deep ASKAP surveys. RACS will cover the whole sky visible from the ASKAP site in Western Australia and will cover the full ASKAP band of 700–1800 MHz. The RACS images are generally deeper than the existing NRAO VLA Sky Survey and Sydney University Molonglo Sky Survey radio surveys and have better spatial resolution. All RACS survey products will be public, including radio images (with $\sim$ 15 arcsec resolution) and catalogues of about three million source components with spectral index and polarisation information. In this paper, we present a description of the RACS survey and the first data release of 903 images covering the sky south of declination $+41^\circ$ made over a 288-MHz band centred at 887.5 MHz.
Site-specific fertilizer nitrogen management in Bt cotton using chlorophyll meter
Arun Shankar, R. K. Gupta, Bijay-Singh
Journal: Experimental Agriculture / Volume 56 / Issue 3 / June 2020
Field experiments were conducted to standardize protocols for site-specific fertilizer nitrogen (N) management in Bt cotton using Soil Plant Analysis Development (SPAD) chlorophyll meter. Performance of different SPAD-based site-specific N management scenarios was evaluated vis-à-vis blanket fertilizer N recommendation. The N treatments comprised a no-N (control), four fixed-time and fixed N doses (60, 90, 120, and 150 kg N ha-1) including the recommended dose (150 kg ha-1), and eight fixed-time and adjustable N doses based on critical SPAD readings of 45 and 41 at first flowering and boll formation stages, respectively. The results revealed that by applying 45 or 60 kg N ha-1 at thinning stage of the crop and critical SPAD value-guided dose of 45 or 30 kg N ha-1 at first flowering stage resulted in yields similar to that recorded by applying the recommended dose of 150 kg N ha-1. However, significantly higher N use efficiency as well as 30–40% less total fertilizer N use was recorded with site-specific N management. Applying 30 kg N ha-1 at thinning and SPAD meter-guided 45 kg N ha-1 at first flowering were not enough and required additional SPAD meter-guided 45 kg N ha-1 at boll formation for sustaining yield levels equivalent to those observed by following blanket recommendation but resulted in 20% less fertilizer N application. Our data revealed that SPAD meter-based site-specific N management in Bt cotton results in optimum yield with dynamic adjustment of fertilizer N doses at first flowering and boll formation stages. The total amount of N fertilizer following site-specific management strategies was substantially less than the blanket recommendation of 150 kg N ha-1, but the extent may vary in different fields.
Experiential learnings from the Nipah virus outbreaks in Kerala towards containment of infectious public health emergencies in India
Rima R. Sahay, Pragya D. Yadav, Nivedita Gupta, Anita M. Shete, Chandni Radhakrishnan, Ganesh Mohan, Nikhilesh Menon, Tarun Bhatnagar, Krishnasastry Suma, Abhijeet V. Kadam, P. T. Ullas, B. Anu Kumar, A. P. Sugunan, V. K. Sreekala, Rajan Khobragade, Raman R. Gangakhedkar, Devendra T. Mourya
Journal: Epidemiology & Infection / Volume 148 / 2020
Published online by Cambridge University Press: 23 April 2020, e90
Nipah virus (NiV) outbreak occurred in Kozhikode district, Kerala, India in 2018 with a case fatality rate of 91% (21/23). In 2019, a single case with full recovery occurred in Ernakulam district. We described the response and control measures by the Indian Council of Medical Research and Kerala State Government for the 2019 NiV outbreak. The establishment of Point of Care assays and monoclonal antibodies administration facility for early diagnosis, response and treatment, intensified contact tracing activities, bio-risk management and hospital infection control training of healthcare workers contributed to effective control and containment of NiV outbreak in Ernakulam.
Effect of dopant on the morphology and electrochemical performance of Ni1-xCaxCo2O4 (0 ≤ x ≤ 0.8) oxide hierarchical structures
D. Guragain, C. Zequine, R. Bhattarai, J. Choi, R. K. Gupta, X. Shen, S. R. Mishra
Journal: MRS Advances / Volume 5 / Issue 48-49 / 2020
Published online by Cambridge University Press: 23 March 2020, pp. 2487-2494
The binary metal oxides are increasingly used as supercapacitor electrode materials in energy storing devices. Particularly NiCo2O4 has shown promising electrocapacitive performance with high specific capacitance and energy density. The electrocapacitive performance of these oxides largely depends on their morphology and electrical properties governed by their energy band-gaps and defects. The morphological structure of NiCo2O4 can be altered via the synthesis route, while the energy band-gap could be altered by doping. Also, doping can enhance crystal stability and bring in grain refinement, which can further improve the much-needed surface area for high specific capacitance. Given the above, this study evaluates the electrochemical performance of Ca-doped Ni1-xCaxCo2O4 (0 ≤ x ≤ 0.8) compounds. This stipulates promising applications for electrodes in future supercapacitors.
Tranexamic acid has no advantage in head and neck surgical procedures: a randomised, double-blind, controlled clinical trial
A Thakur, S Gupta, J S Thakur, R S Minhas, R K Azad, M S Vasanthalakshmi, D R Sharma, N K Mohindroo
Journal: The Journal of Laryngology & Otology / Volume 133 / Issue 12 / December 2019
Published online by Cambridge University Press: 18 November 2019, pp. 1024-1032
To assess the effect of tranexamic acid in head and neck surgical procedures.
A prospective, double-blind and randomised, parallel group, placebo-controlled clinical trial was conducted. Ninety-two patients undergoing various head and neck surgical procedures were randomised. Subjects received seven infusions of coded drugs (tranexamic acid or normal saline) starting at the time of skin closure. Haematological, biochemical, blood loss and other parameters were observed by the staff, who were blinded to patients' group allocation (case or control).
Patients were analysed on the basis of type of surgery. Fifty patients who had undergone surgical procedures, including total thyroidectomy, total parotidectomy, and various neck dissections with or without primary tumour excision, were included in the first group. The second group comprised 41 patients who had undergone hemithyroidectomy, lobectomy or superficial parotidectomy. There was no statistical difference in blood parameters between both groups. There was a reduction in post-operative drain volume, but this was not significant.
Although this prospective, randomised, placebo-controlled clinical trial found a reduction in post-operative drain volume in tranexamic acid groups, the difference was not statistically significant between the various head and neck surgical procedure groups.
Rice straw biochar improves soil fertility, growth, and yield of rice–wheat system on a sandy loam soil
R. K. Gupta, Ashaq Hussain, Yadvinder-Singh, S. S. Sooch, J. S. Kang, Sandeep Sharma, G. S. Dheri
Journal: Experimental Agriculture / Volume 56 / Issue 1 / February 2020
Print publication: February 2020
Biochar has received attention due to its potential for mitigating climate change through carbon sequestration in soil and improving soil quality and crop productivity. This study evaluated the effects of rice straw biochar (RSB) and rice husk ash (RHA) each applied at 5 Mg ha−1 and four N levels (0, 40, 80, and 120 kg ha−1) on soil fertility, growth, and yield of rice and wheat for three consecutive rice–wheat rotations. RSB significantly increased electrical conductivity, dehydrogenase activity, and P and K contents when compared to control (no amendment) up to 7.5 cm soil depth. Both RSB and RHA did not influence shoot N concentration in wheat plant but significantly increased P and K concentrations at 60 days after sowing. Grain yields of both rice and wheat were significantly higher in RSB as compared to control (no amendment) and RHA treatments. While the highest grain yields of rice and wheat were observed at 120 kg N ha−1 in RHA and no biochar-treated plots, a significant increase in grain yields was observed at 80 kg N ha−1 in RSB treatment, thereby saving 40 kg N ha−1 in each crop. Both agronomic and recovery N efficiencies in rice and wheat were significantly higher in RSB-amended soil compared to control. Significant positive correlations were observed between soil N, P, and K concentrations and total N, P, and K concentrations in aboveground biomass of wheat at 60 days after sowing. This study showed the potential benefits of applying RSB for improving soil fertility and yields of rice and wheat in a rice–wheat system.
The influence of maternal and infant nutrition on cardiometabolic traits: novel findings and future research directions from four Canadian birth cohort studies
Nutrition Society Summer Meeting 2018
R. J. de Souza, M. A. Zulyniak, J. C. Stearns, G. Wahi, K. Teo, M. Gupta, M. R. Sears, P. Subbarao, S. S. Anand
Journal: Proceedings of the Nutrition Society / Volume 78 / Issue 3 / August 2019
Print publication: August 2019
A mother's nutritional choices while pregnant may have a great influence on her baby's development in the womb and during infancy. There is evidence that what a mother eats during pregnancy interacts with her genes to affect her child's susceptibility to poor health outcomes including childhood obesity, pre-diabetes, allergy and asthma. Furthermore, after what an infant eats can change his or her intestinal bacteria, which can further influence the development of these poor outcomes. In the present paper, we review the importance of birth cohorts, the formation and early findings from a multi-ethnic birth cohort alliance in Canada and summarise our future research directions for this birth cohort alliance. We summarise a method for harmonising collection and analysis of self-reported dietary data across multiple cohorts and provide examples of how this birth cohort alliance has contributed to our understanding of gestational diabetes risk; ethnic and diet-influences differences in the healthy infant microbiome; and the interplay between diet, ethnicity and birth weight. Ongoing work in this birth cohort alliance will focus on the use of metabolomic profiling to measure dietary intake, discovery of unique diet–gene and diet–epigenome interactions, and qualitative interviews with families of children at risk of metabolic syndrome. Our findings to-date and future areas of research will advance the evidence base that informs dietary guidelines in pregnancy, infancy and childhood, and will be relevant to diverse and high-risk populations of Canada and other high-income countries.
LO04: Canadian best practice diagnostic algorithm for acute aortic syndrome
R. Ohle, S. McIsaac, J. Yan, K. Yadav, P. Jetty, R. Atoui, N. Fortino, B. Wilson, N. Coffey, T. Scott, A. Cournoyer, F. Rubens, D. Savage, D. Ansell, J. Middaugh, A. Gupta, B. Bittira, Y. Callaway, S. Bignucolo, B. Mc Ardle, E. Lang
Journal: Canadian Journal of Emergency Medicine / Volume 21 / Issue S1 / May 2019
Published online by Cambridge University Press: 02 May 2019, pp. S7-S8
Print publication: May 2019
Introduction: Acute aortic syndrome (AAS) is a time sensitive aortic catastrophe that is often misdiagnosed. There are currently no Canadian guidelines to aid in diagnosis. Our goal was to adapt the existing American Heart Association (AHA) and European Society of Cardiology (ESC) diagnostic algorithms for AAS into a Canadian evidence based best practices algorithm targeted for emergency medicine physicians. Methods: We chose to adapt existing high-quality clinical practice guidelines (CPG) previously developed by the AHA/ESC using the GRADE ADOLOPMENT approach. We created a National Advisory Committee consisting of 21 members from across Canada including academic, community and remote/rural emergency physicians/nurses, cardiothoracic and cardiovascular surgeons, cardiac anesthesiologists, critical care physicians, cardiologist, radiologists and patient representatives. The Advisory Committee communicated through multiple teleconference meetings, emails and a one-day in person meeting. The panel prioritized questions and outcomes, using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to assess evidence and make recommendations. The algorithm was prepared and revised through feedback and discussions and through an iterative process until consensus was achieved. Results: The diagnostic algorithm is comprised of an updated pre test probability assessment tool with further testing recommendations based on risk level. The updated tool incorporates likelihood of an alternative diagnosis and point of care ultrasound. The final best practice diagnostic algorithm defined risk levels as Low (0.5% no further testing), Moderate (0.6-5% further testing required) and High ( >5% computed tomography, magnetic resonance imaging, trans esophageal echocardiography). During the consensus and feedback processes, we addressed a number of issues and concerns. D-dimer can be used to reduce probability of AAS in an intermediate risk group, but should not be used in a low or high-risk group. Ultrasound was incorporated as a bedside clinical examination option in pre test probability assessment for aortic insufficiency, abdominal/thoracic aortic aneurysms. Conclusion: We have created the first Canadian best practice diagnostic algorithm for AAS. We hope this diagnostic algorithm will standardize and improve diagnosis of AAS in all emergency departments across Canada.
Identification of proteins for controlled nucleation of metal-organic crystals for nanoenergetics
Zachary E. Reinert, Chia-Suei Hung, Andrea R. Poole, Joseph M. Slocik, Marquise G. Crosby, Srikanth Singamaneni, Rajesh R. Naik, Patrick B. Dennis, Wendy J. Crookes-Goodson, Maneesh K. Gupta
Journal: MRS Communications / Volume 9 / Issue 2 / June 2019
Published online by Cambridge University Press: 24 April 2019, pp. 456-463
Here, we report that a marine sandworm Nereis virens jaw protein, Nvjp1, nucleates hemozoin with similar activity as the native parasite hemozoin protein, HisRPII. X-ray diffraction and scanning electron microscopy confirm the identity of the hemozoin produced from Nvjp1-containing reactions. Finally, we observed that nAl assembled with hemozoin from Nvjp1 reactions has a substantially higher energetic output when compared to analogous thermite from the synthetic standard or HisRPII-nucleated hemozoin. Our results demonstrate that a marine sandworm protein can nucleate malaria pigment and set the stage for engineering recombinant hemozoin production for nanoenergetic applications.
Repeated Chlamydia trachomatis infections are associated with lower bacterial loads
K. Gupta, R. K. Bakshi, B. Van Der Pol, G. Daniel, L. Brown, C. G. Press, R. Gorwitz, J. Papp, J. Y. Lee, W. M. Geisler
Published online by Cambridge University Press: 04 October 2018, e18
Chlamydia trachomatis (CT) infections remain highly prevalent. CT reinfection occurs frequently within months after treatment, likely contributing to sustaining the high CT infection prevalence. Sparse studies have suggested CT reinfection is associated with a lower organism load, but it is unclear whether CT load at the time of treatment influences CT reinfection risk. In this study, women presenting for treatment of a positive CT screening test were enrolled, treated and returned for 3- and 6-month follow-up visits. CT organism loads were quantified at each visit. We evaluated for an association of CT bacterial load at initial infection with reinfection risk and investigated factors influencing the CT load at baseline and follow-up in those with CT reinfection. We found no association of initial CT load with reinfection risk. We found a significant decrease in the median log10 CT load from baseline to follow-up in those with reinfection (5.6 CT/ml vs. 4.5 CT/ml; P = 0.015). Upon stratification of reinfected subjects based upon presence or absence of a history of CT infections prior to their infection at the baseline visit, we found a significant decline in the CT load from baseline to follow-up (5.7 CT/ml vs. 4.3 CT/ml; P = 0.021) exclusively in patients with a history of CT infections prior to our study. Our findings suggest repeated CT infections may lead to possible development of partial immunity against CT.
Comparison of basal lamella relaxing incision and combined conventional medialisation and controlled synechiae in functional endoscopic sinus surgery: a randomised prospective study
D D Maharaj, R S Virk, S Bansal, A K Gupta
Journal: The Journal of Laryngology & Otology / Volume 132 / Issue 7 / July 2018
To compare combined conventional Freer medialisation and controlled synechiae, performed for middle meatal access (during the initial steps of functional endoscopic sinus surgery) and post-operative middle turbinate medialisation, with basal lamella relaxing incision, the latter of which is a single step for achieving both middle meatal access and post-operative medialisation. The study also compared the effects of controlled synechiae and basal lamella relaxing incision on post-operative olfaction.
A randomised prospective study was performed on 52 nasal cavity sides (32 patients). Only basal lamella relaxing incision was performed in one group, and both conventional medialisation and controlled synechiae were performed in the other. Intra-operative and post-operative photography was used to measure the middle meatal area. A pocket smell test was used to assess olfaction.
There were no significant differences in operative middle meatal access and post-operative medialisation of the middle turbinate. Post-operative olfaction was affected more in the combined conventional medialisation and controlled synechiae group, compared to the basal lamella relaxing incision group, but this finding was not statistically significant.
Basal lamella relaxing incision is an effective single-step technique for achieving adequate middle meatal access and post-operative medialisation, with no significant effect on olfaction.
P058: Paramedic recognition and management of anaphylaxis in the prehospital setting
M. Welsford, R. Gupta, K. Samoraj, S. Sandhanwalia, M. Kerslake, L. Ryan, C. Shortt
Published online by Cambridge University Press: 11 May 2018, p. S77
Introduction: Anaphylaxis is a life-threatening condition that paramedics are equipped to treat effectively in the field. Current literature suggests improvements in paramedic recognition and treatment of anaphylaxis could be made. The aim of this study was to compare the proportion of cases of anaphylaxis appropriately treated with epinephrine by paramedics before and after a targeted educational intervention. Methods: This was a retrospective medical records review of patients with anaphylaxis managed by primary or advanced care paramedics in five Emergency Medical Service areas in Ontario, before and after an educational module was introduced. This module included education on anaphylaxis diagnosis, recognition, treatment priorities, and feedback on the recognition and management from the before period. All paramedic call records (PCRs) coded as local allergic reaction or anaphylaxis during 12-month periods before and after the intervention were reviewed by trained data abstractors to determine if patients met an international definition of anaphylaxis. The details of interventions performed by the paramedics were used to determine primary and secondary outcomes. Results: Of the 600 PCRs reviewed, 99/120 PCRs in the before and 300/480 in the after period were included. Of the charts included, 63/99 (63.6%) in the before and 136/300 (45.3%) in the after period met criteria for anaphylaxis (p=0.002). Of the cases meeting anaphylaxis criteria, 41/63 (65.1%) in the before and 88/136 (64.7%) in the after period were correctly identified as anaphylaxis (p=0.96). Epinephrine was administered in 37/63 (58.7%) of anaphylaxis cases in the before period and 76/136 (55.9%) in the after period (p=0.70). Anaphylactic patients with only two-system involvement received epinephrine in 20/40 (50.0%) cases in the before period and 45/93 (48.4%) in the after period (p=0.86). Conclusion: There are gaps in paramedic recognition and management of anaphylaxis, particularly in cases of two-system involvement. These gaps persisted after the implementation of an educational intervention. Other quality interventions and periodic refreshers may be necessary to improve prehospital treatment of anaphylaxis. Limitations include an increase in overall cases and decrease in rate of true anaphylaxis in the after period, which may relate to better case identification after electronic PCR implementation and changes in paramedic recognition.


text:
Posted on July 2, 2010 July 2, 2010 by Michael Clarke
Positive Feedback from Agents and A Publisher
I've been so busy preparing for Wednesday's reading that I haven't had time to blog about other events that may have more eventual significance.
I went to the Winchester Writers' Conference last Friday and had three appointments — two with agents and one with a publisher.
The agents had both read work that I'd supplied in advance and gave me useful feedback. I sent the first fifteen pages of The Angel (about 5,000-6,000 words) to someone from one of the biggest literary agencies in London (A.P. Watt). She was very complimentary about what she read — said she'd 'really enjoyed it. She praised the evocation in the sense of place as she lives in the Hackney/Shoreditch area herself. She gave some constructive comments about perhaps changing the opening around a bit — which were quite intuitive in a way as what she suggested was the original way I'd opened the novel before changing it to reflect what I read at our showcase on Wednesday. It was a bit too late for me to change the reading. The two points of view worked well for her and also the genre — which she described as on 'the border between literary and commercial fiction' which is a good place to be apparently. I asked if this was the type of novel that she would represent and she said that it was. I seem to remember her complementing me by saying I 'could write'.
I also pitched the novel completely cold to an editor from a huge publisher (I happened to get a spare slot in her schedule on the day). I had to show her my blurb and my reading for the City reading as that was all I had available. But she was also very encouraging — saying it was 'funny' and something that people would definitely want to read. In the end she took away all the improvised material I showed her and it's now at the publishers.
The other agent I saw only asked for the first ten pages and he had a different take on the novel which, I suspect, might have been influenced by not seeing the missing five pages that the other agent had read. While she thought it would appeal very widely as it was, at heart, a love story I think that's because the extra part had a lot of Kim and her interior. The first agent complemented the quality of the writing but wasn't sure where it would be positioned in the market — although one of the other delegates later told me that this agent wasn't a fiction specialist — but perhaps that was because he hadn't seen enough of the book? Certainly, the majority opinion out of the three was that it was very marketable.
After these sort of events, it's probably natural to wonder if the agents really meant what they said or were they just being polite but it's not really in their interest to say something's good if they don't like it — it just means wasted time for them in the office. So I think that's pretty encouraging — everything was read and submitted as it would be for a proper agent submission when a novel's finally ready and they were quite lengthy samples of the book so weren't taken out of context.
CategoriesPublishing Tagsagents, feedback, Publishing, Winchester Writers Conference
3 Replies to "Positive Feedback from Agents and A Publisher"
Bren Gosling says:
good to hear about this positive feedback on your novel Mike!Encouraging! How far have you got towards a first draft of The Angel? I still have alot to do on mine but I hope with the mentoring Emma will provide I will have a solid framework to support a constructive way forward. My aim is to have a decent complete first draft by Christmas…
Michael Clarke says:
I'd like to get a first draft done by September then spend until the end of the year polishing it. Now I don't have to spend about 12 hours a week travelling to and from City University I can spend the time on the business of actually writing (he said hopefully).
I'd love to do the mentoring as well but have to watch the funds at the moment — especially if we're paying to carry on workshopping. Considering other avenues as well — like an MA.
I'm taking Penny Rudge as my role model — similar tone and subject matter in her novel — and she went the MA and PhD route.
PS. Went to a poetry meeting last night and had a sonnet of mine workshopped — very positive comments — people coming up to me at the end saying that it was saying something very profound.
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redpajama_set_name: RedPajamaCommonCrawl


text:
Why Halloween candy is now scarier than the clowns
The national obesity crisis that kills more Americans than smoking is directly linked to people eating far too much sugar as children, growing evidence suggests.
New findings on the subject have been published in a scientific journal shortly ahead of Halloween, when people spend $2.6 billion annually nationwide on candy.
Soaring obesity rates in the last 30 years are likely "a legacy of increased consumption of excess sugars among children of the 1970s and 1980s," when the use of cheap industrial sweeteners such as high-fructose corn syrup first took off.
Alex Bentley, Damian Ruck and Hillary Fouts, researchers at the University of Tennessee, published their study in the scientific journal Economics and Human Biology and based their analysis on national data on consumption of sugars and health outcomes, including body mass, by age cohort.
U.S. obesity rates have doubled since 1990, national data show. Today one-fifth of children age 6 to 19 are clinically obese. "Consumed from a young age, sugar consumption appears to have long-lasting effects, not just habitually but also physiologically," the researchers add.
Scientific studies have shown a link between infant and childhood obesity and higher consumption of sugars at the earliest ages — even while in gestation.
The pattern for poor diet is set early in life and the effects are cumulative, medical experts note.
According to the U.S. Department of Agriculture, national consumption of added sugars such as high-fructose corn syrup rocketed from around 70 pounds per person per year in 1970 to almost 90 pounds by 2000. The researchers note this is equal to an average of extra 100 calories per person per day.
That adds up to 36,500 calories a year — enough to add about 10 pounds in fat to the human body, experts note.
It's not just about body-mass index. Type 2 diabetes, fatty liver disease and hypertension are all now being seen among children for the first time, warned a recent paper in the medical journal Pediatric Obesity.
These have all been associated with the so-called "Western Diet," high in refined carbohydrates and especially industrial sweeteners. In one study, children's' health measures improved almost immediately when researchers replaced some of the sugars in their diet with starches like potatoes — even when the total amount of calories stayed the same.
"We agree people should be empowered to make informed choices when it comes to enjoying their favorite treats — at Halloween and all throughout the year," Christopher Gindelsperger, spokesman for the National Confectioners' Association, told MarketWatch.
Chocolate and candy companies "have come together to help people manage their sugar intake," he said. Examples, he said, include more options in smaller, 200 calories or less pack sizes and clear front-of-pack calorie labels.
Don't miss: The FDA wants to stop you from buying candy from your office vending machine
In fact, the sugared beverages that children drink every day are a bigger problem than Halloween, said Alex Bentley, one of the co-authors on the University of Tennessee research.
"A leading sweet-tea brand might have about 42 grams of sugar in the bottle — that's the equivalent of a dozen Tootsie rolls," he says. "Imagine the effects of drinking one bottle with every meal, that's like eating three dozen Tootsie rolls every day. So I'm not so worried about Halloween by comparison."
: How to Invest: ETF and fund fees can take a big bite out of your returns
The Margin: 'The greatest hole-in-one in history' just happened at the Masters, and it has to be seen to be believed
: Whether Tesla did sell any cars for bitcoins remains unclear and the company isn't saying
Key Words: Watch Ocasio-Cortez demolish Florida Republican who called her 'disgusting' and other choice words
CityWatch: As New York City hosts a Restaurant Week like no other, Cuomo suggests indoor dining could soon return
Elizabeth Warren wants to force companies to give employees predictable schedules


Easy Chicken Coop Designs Free With Check Out My 4×8 Plans Free Learn How To Build A is free HD wallpaper. This wallpaper was upload at June 10, 2017 upload by in .
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Consumables are expected to hold a significant share in aromatherapy market with rapidly surging therapeutic application of the essential oils for several disease conditions. Consumables hold the potential of immense healing properties naturally, thereby turning out to be significantly lucrative for the revenue growth of aromatherapy market. Growing demand for treatment of skin and heart diseases is expected to push the sales of consumables in the aromatherapy market – and that aromatherapy market leads us to the popular question of carrier oils vs. essential oils.
Consumables include essential oils that are extracted from plants and are processed naturally. They are non-toxic and safe for topical inhalation uses. Rapid increase in the number of people adopting self-medication remedies for the common cold and pain is expected to further stimulate the demand for consumables. Rising number of clinical aromatherapy programs will continue to drive the demand and supply of consumables in the aromatherapy market owing to increasing consumer need for attaining natural measures.
Both carrier oils and essential oils are vital in the aromatherapy with individual therapeutic benefits. Carrier oils are sourced usually from fatty parts of the plants whereas essential oils are sourced from the non-fatty areas and aromatic portion of the plants. Carrier oils do not hold potency, which helps in eliminating skin irritations or burns when applied directly. However, essential oils are highly potent and holds high probability of burns with severe skin irritation. Therefore, need for diluting essential oils with carrier oil stimulates the demand for carrier oils in aromatherapy market. Surging cases of hair and skin treatments is expected to further drive the demand for carrier oils in aromatherapy.
Carrier oils do not easily evaporate and degrade whereas essential oils evaporate and degrade especially when exposed to light. Need for obtaining nutrient benefits drives the sales of carrier oils as essential oils loose nutrients during the distillation process. Usage of plastic bottles is possible only with carrier oils as essential oils when stored in plastic bottles tend to dissolve. Contamination of essential oils is prevented with increasing usage of glass and metal containers. Non-volatile factors of carrier oils further increases its preference amongst the consumer-base in aromatherapy market.
Moisturizing benefits of carrier oils with provision of direct usage on skin is expected to significantly drive the demand and supply of carrier oils across the globe. Carrier oils are expected to continue gain traction in the hair treatment due to its nourishing, strengthening, sealing and moisturizing properties. Carrier oils helps in dissolving and loosening hardened build-up hair shaft and scalp. Moisturizing benefits with carrier oils are likely to gain notable traction amongst the population with dry hair.
Carrier oils such as "Extra Virgin" Olive oil are highly beneficial for preventing and curing hair loss. Several carrier oils such as coconut oils act as hot-oil deep treatment conditioners, which is considered as an emerging trends in aromatherapy. Carrier oils further help in scalp circulation along with presence of the antioxidants that help with hair growth. Some carrier oils such as almond oil contain light smell, which in most preferred by the millennials. Almond oils hold potential magnesium properties that helps in reducing hair shedding and can significantly improve hair health. Apart from this, almond oils also help in eliminating dry scalp and dandruff. Growing availability of carrier oils at affordable prices compared to essential oils will further stimulate its demand in aromatherapy market.
On the other hand, essential oils are also preferred by a concentrated population as they significantly help in scalp health and scalp treatments. In DIY hair concoctions and hair products, essential oils are seen to play an essential role.
Carrier oils and essential oils both have their own important uses, and both can contribute to a health-focused lifestyle. However, it's very important to understand the difference and know which one is best for individual situations. Each have their own strengths.


a supplementary Masterlanguage course may be right up your street!
Masterlanguage is a national programme that offers courses in German, English, French, Italian, Classics (Greek and Latin) and Dutch. The courses are taught in the target language (except Greek and Latin) and are jointly organized by lecturers from Radboud University, the University of Groningen, Leiden University, Utrecht University, the University of Amsterdam and VU University Amsterdam. More information about the courses, entry requirements and registration can be found on the Masterlanguage website: www.masterlanguage.nl . In addition to courses, Masterlanguage also organizes a range of other interesting activities, such as lectures and masterclasses Masterlanguage enables you to meet lecturers from a variety of expertise fields and from all over the Netherlands, as well as fellow language students from other universities.
Last modified: 28 July 2016 4.17 p.m.


text:
TransAsia Airways () – tajwańska linia lotnicza z siedzibą w Tajpej. Obsługiwała połączenia krajowe, zagraniczne (Kambodża, kontynentalne Chiny, Japonia, Makau, Korea Południowa, Tajwan i Tajlandia) oraz czarterowe. Głównym hubem był Port lotniczy Tajpej-Songshan.

Linia zakończyła działalności 22 listopada 2016 r.

Flota

 9 ATR 72-600

Tajwańskie linie lotnicze
Tajpej

redpajama_set_name: RedPajamaWikipedia


text:
Alexander George "Alex" Karras (Gary (Indiana), 15 juli 1935 – Los Angeles, 10 oktober 2012) was een Amerikaans acteur, professioneel worstelaar en American footballspeler. Hij speelde de rol van pleegvader George Papadapolis in de televisieserie Webster.

Alex Karras speelde football in het team van University of Iowa Hawkeyes en speelde in de National Football Leage waar hij speelde voor de Detroit Lions van 1958-1962 en 1964-1970. In totaal speelde hij 161 wedstrijden. Zijn broers Lou en Theodore waren zelf ook professionele American footballspelers. Verder was Alex Carras in de periode 1957-1971 een professionele worstelaar tot een knieblessure zijn loopbaan beëindigde.

Alex Karras was getrouwd met Ivalyn Joan Jurgensen van 1958 tot hun scheiding in 1976 met wie hij vijf kinderen had. Hij hertrouwde  met actrice Susan Clark van 1980 tot zijn dood in 2012. Samen hadden ze een dochter. Hij stierf op 77-jarige leeftijd aan nierfalen.

Filmografie
 Hardcase (1972)
 The 500 Pound Jerk (1973)
 The Great Lester Boggs (1974)
 Blazing Saddles (1974)
 Babe (1975)
 Win, Place or Steal (1975)
 Mad Bull (1977)
 Jacob Two-Two Meets the Hooded Fang (1978)
 FM (1978)
 Alcatraz: The Whole Shocking Story (1980)
 When Time Ran Out... (1980)
 Jimmy B. & André (1980)
 Nobody's Perfekt (1981)
 Word of Honor (1981, niet op aftiteling)
 Maid in America (1982)
 Porky's (1982)
 Victor Victoria (1982)
 Against All Odds (1984)
 The Street Corner Kids (1994)
 The Street Corner Kids: The Sequel (1995)
 Buffalo '66 (1998)

Televisieseries
 Daniel Boone (1969)
 Love, American Style (1971)
 The Odd Couple (1973)
 M*A*S*H (1974)
 McMillan & Wife (1974)
 ABC Afterschool Specials (1976)
 Good Heavens (1976)
 Mulligan's Stew (1977)
 Centennial (1978-1979), 12 afleveringen
 Masada (1981)
 Webster (1983-1989), 150 afleveringen
 Faerie Tale Theatre (1984)
 Civil Wars (1993)
 Fudge (1995)
 ABC Weekend Specials (1995)
 Arli$$ (1996)
 The Tom Show (1998)

Externe links
 Overlijdensbericht op noordhollandsdagblad.nl
  Overlijdensbericht op news.yahoo.com

Amerikaans filmacteur
Amerikaans televisieacteur
Amerikaans professioneel worstelaar
Amerikaans American footballspeler


text:
=head1 CONTACT

  Please email comments or questions to the public Ensembl
  developers list at <http://lists.ensembl.org/mailman/listinfo/dev>.

  Questions may also be sent to the Ensembl help desk at
  <helpdesk.org>.

=cut

# dump_gvf.pl - Create GVF dumps from Ensembl variation databases
#
# see end of file for documentation

use strict;
use warnings;

use Data::Dumper;
use Getopt::Long;
use Pod::Usage;

use Bio::EnsEMBL::Registry;
use Bio::EnsEMBL::Variation::Utils::EnsEMBL2GFF3;
use Bio::EnsEMBL::Utils::Sequence qw(reverse_comp);

my $species;
my $output_file;
my $registry;
my $host;
my $user;
my $somatic;
my $compress;
my $use_iterator;
my $include_failed;
my $just_failed;
my $individual_name;
my $population_name;
my $set_name;
my $chunk_size;
my $include_consequences;
my $include_coding_details;
my $include_global_maf;
my @seq_region_names;
my $include_svs;
my $just_svs;
my $help;

$| = 1;

GetOptions(
    "species|s=s"                   => \$species,
    "output|o=s"                    => \$output_file,
    "registry|r=s"                  => \$registry,
    "host=s"                        => \$host,
    "user=s"                        => \$user,
    "individual|i=s"                => \$individual_name,
    "population|p=s"                => \$population_name,
    "set=s"                         => \$set_name,
    "somatic"                       => \$somatic,
    "compress|c"                    => \$compress,
    "use_iterator"                  => \$use_iterator,
    "include_failed"                => \$include_failed,
    "just_failed"                   => \$just_failed,
    "chunk_size|cs=i"               => \$chunk_size,
    "include_consequences"          => \$include_consequences,
    "include_coding_details"        => \$include_coding_details,
    "include_global_maf"            => \$include_global_maf,
    "seq_region|sr=s"               => \@seq_region_names,
    "include_structural_variations" => \$include_svs,
    "just_structural_variations"    => \$just_svs,
    "help|h"                        => \$help,
) or die pod2usage(1);

pod2usage(1) if $help;

# the only parameter we require is species
die "species argument required, try --help for usage instructions\n" unless $species;

die "Can't fetch for a population and an individual at once"
    if $population_name && $individual_name;

# chunk size is in kilobases
$chunk_size *= 1000 if defined $chunk_size;

# if the user wants just structural variants that implies that SVs should be included
$include_svs = 1 if $just_svs;

# default to a sensible file name
$output_file ||= "$species.gvf";

my $reg = 'Bio::EnsEMBL::Registry';

if ($host) {
    # if we are supplied with a host, try to load the registry from there
    $user ||= 'anonymous';
    $reg->load_registry_from_db(-host => $host, -user => $user);
}
else {
    # otherwise use the registry file supplied (or default to the
    # ENSEMBL_REGISTRY environment variable)
    $reg->load_all($registry);
}

my $cdba = $reg->get_DBAdaptor($species, 'core')
    or die "Failed to get core DBAdaptor";

my $vdba = $reg->get_DBAdaptor($species, 'variation')
    or die "Failed to get variation DBAdaptor";

my $failed_descs;
my $failed_ids;

if ($include_failed || $just_failed) {

    # include failed variations, but flag them with an attribute
    $vdba->include_failed_variations(1);

    # joining to variation and failed variation is too slow, so
    # we cache the entire failed_variation table in memory, just
    # storing the failed_description_id to save memory. We also
    # store the failed_description table in memory to map these
    # ids to the description

    my $dbh = $vdba->dbc->db_handle;

    my $sth = $dbh->prepare(qq{
        SELECT  failed_description_id, description
        FROM    failed_description
    });

    $sth->execute;

    while (my ($id, $desc) = $sth->fetchrow_array) {
        $failed_descs->{$id} = $desc;
    }

    $sth = $dbh->prepare(qq{
        SELECT  variation_id, failed_description_id
        FROM    failed_variation
    });

    $sth->execute;

    my $v_id;
    my $desc_id;

    $sth->bind_columns(\$v_id, \$desc_id);

    while ($sth->fetch) {
        $failed_ids->{$v_id} = $desc_id;
    }
}

my $individual;

if ($individual_name) {
    my $ia = $vdba->get_IndividualAdaptor;
    $individual = $ia->fetch_all_by_name($individual_name)->[0]
        or die "Didn't find individual '$individual_name'";
}

my $population;

my $alleles_by_variation_id;

if ($population_name) {
    my $pa = $vdba->get_PopulationAdaptor;
    $population = $pa->fetch_by_name($population_name)
        or die "Didn't find population '$population_name'";

    # joining to variation and allele etc. is too slow so we cache
    # all alleles and frequencies for the population in memory

    my $dbh = $vdba->dbc->db_handle;
    my $sth = $dbh->prepare(qq{
        SELECT  a.variation_id, ac.allele, a.frequency
        FROM    allele a, allele_code ac
        WHERE   a.allele_code_id = ac.allele_code_id
        AND     population_id = ?
    });

    $sth->execute($population->dbID);

    my $v_id;
    my $allele;
    my $freq;

    $sth->bind_columns(\$v_id, \$allele, \$freq);

    while ($sth->fetch) {
        $alleles_by_variation_id->{$v_id}->{$allele} = defined $freq ? $freq : '';
    }
}

my $set;

if ($set_name) {
    my $vsa = $vdba->get_VariationSetAdaptor;
    $set = $vsa->fetch_by_name($set_name)
        or die "Didn't find set '$set_name'";
}

# open the output file

open GVF, ">$output_file" or die $!;

# get our slices

my $slices;

my $sa = $cdba->get_SliceAdaptor;

if (@seq_region_names) {
    for my $name (@seq_region_names) {
        my $slice = $sa->fetch_by_region('toplevel', $name)
            or die "Failed to get a slice for seq region name: $name";
        push @$slices, $slice;
    }
}
else {

#    # find all the unique seq_region_ids in the database
#    # and fetch a slice for each of them
#
#    my $dbh = $vdba->dbc->db_handle;
#
#    my %sr_ids;
#
#    if ($include_svs) {
#        my $sth = $dbh->prepare(qq{
#            SELECT  DISTINCT(seq_region_id)
#            FROM    structural_variation
#        });
#
#        $sth->execute;
#
#        while (my ($sr_id) = $sth->fetchrow_array) {
#            $sr_ids{$sr_id} = 1;
#        }
#    }
#
#    unless ($just_svs) {
#        my $sth = $dbh->prepare(qq{
#            SELECT  DISTINCT(seq_region_id)
#            FROM    variation_feature
#        });
#
#        $sth->execute;
#
#        while (my ($sr_id) = $sth->fetchrow_array) {
#            $sr_ids{$sr_id} = 1;
#        }
#    }
#
#    for my $sr_id (keys %sr_ids) {
#        my $slice = $sa->fetch_by_seq_region_id($sr_id);
#        die "seq_region_id $sr_id found in variation database but not in core?" unless $slice;
#        push @$slices, $slice;
#    }

    #$slices = $sa->fetch_all('toplevel', undef, 1, 0);
    $slices = $sa->fetch_all('toplevel');
    die "Didn't find any toplevel slices for $species?" unless @$slices;
}

# print the GVF header for the first slice, without sequence_region information
# because we add that for all slices later, but include details of the individual
# or population as necessary

print GVF $slices->[0]->gvf_header(
    no_sequence_region  => 1,
    individual          => $individual,
    population          => $population,
);

# print a sequence-region line in the GVF file for each slice

for my $slice (@$slices) {
    print GVF '##sequence-region ', $slice->seq_region_name, ' ',$slice->start, ' ', $slice->end, "\n";
}

# just use a file-wide count for the ID attribute
my $id_count = 0;

my $prev_svs;

while (my $slice = shift @$slices) {

    # only operate on chunk_size sub slices to avoid running out of memory

    my $sub_slice_start = 1;

    $chunk_size ||= $slice->end;

    #warn "Fetching by slice: ".$slice->name." chunk size: ".$chunk_size;

    while ($sub_slice_start < $slice->end) {

        my $sub_slice_end = $sub_slice_start + $chunk_size - 1;

        $sub_slice_end = $slice->end if $sub_slice_end > $slice->end;

        my $sub_slice = $slice->sub_Slice($sub_slice_start, $sub_slice_end)
            or die "No sub slice for $sub_slice_start - $sub_slice_end?";

        $sub_slice_start = $sub_slice_end + 1;

        unless ($just_svs) {

            my $vfa  = $vdba->get_VariationFeatureAdaptor;

            my $vfs;

            if ($use_iterator) {
                $vfs = $vfa->fetch_Iterator_by_Slice_constraint($sub_slice, '');
            }
            elsif ($somatic) {
                $vfs = $vfa->fetch_all_somatic_by_Slice_constraint_with_TranscriptVariations($sub_slice);
            }
            elsif ($set) {
                $vfs = $vfa->fetch_all_by_Slice_VariationSet($sub_slice, $set);
            }
            elsif ($include_consequences) {
                $vfs = $vfa->fetch_all_by_Slice_constraint_with_TranscriptVariations($sub_slice);
            }
            else {
                $vfs = $vfa->fetch_all_by_Slice($sub_slice);
            }

            # we pre-fetch all the genotypes for this slice and individual to
            # speed things up below

            my $gt_hash;

            if ($individual) {

                my $igta = $vdba->get_IndividualGenotypeAdaptor;

                my $igts = $igta->fetch_all_by_Slice($sub_slice, $individual);

                for my $igt (@$igts) {

                    my $key = join('_',
                        $igt->slice->seq_region_name,
                        $igt->seq_region_start,
                        $igt->seq_region_end,
                    );

                    my $gts = $gt_hash->{$key} ||= [];

                    my $seen = 0;

                    if (@$gts) {
                        for my $gt (@$gts) {
                            if (($gt->allele1 eq $igt->allele1 && $gt->allele2 eq $igt->allele2) ||
                                ($gt->allele1 eq $igt->allele2 && $gt->allele2 eq $igt->allele1)) {
                                $seen++;
                                last;
                            }
                        }
                    }

                    push @$gts, $igt unless $seen;
                }
            } # end individual

            # iterate over our variation_features

            VF : while (my $vf = ($use_iterator ? $vfs->next : shift @$vfs)) {

                my $attrs;

                my $comment = '';

                if ($individual) {

                    # we're making a file for an individual, so fetch the genotypes

                    my $key = join('_',
                        $vf->slice->seq_region_name,
                        $vf->seq_region_start,
                        $vf->seq_region_end,
                    );

                    my @gts = @{ $gt_hash->{$key} || [] };

                    GT : for my $gt (@gts) {

                        my $gt1 = $gt->allele1;
                        my $gt2 = $gt->allele2;

                        unless ($vf->strand == $gt->strand) {
                            reverse_comp(\$gt1);
                            reverse_comp(\$gt2);
                        }

                        my @alleles = split /\//, $vf->allele_string;

                        my $ref_allele = shift @alleles;

                        my $hom = $gt1 eq $gt2;

                        my $gt1_is_ref = $gt1 eq $ref_allele;
                        my $gt2_is_ref = $gt2 eq $ref_allele;

                        my $gt1_in_alt;
                        my $gt2_in_alt;

                        if ($hom && $gt1_is_ref) {
                            # homozygous for the reference, don't include
                            next VF;
                        }

                        my $variant_seq;

                        for my $allele (@alleles) {
                            $gt1_in_alt = 1 if $allele eq $gt1;
                            $gt2_in_alt = 1 if $allele eq $gt2;
                            last if ($gt1_in_alt && $gt2_in_alt);
                        }

                        if ($hom && $gt1_in_alt) {
                            # homozygous for alt
                            $variant_seq = "$gt1";
                        }
                        elsif ($gt1_is_ref && $gt2_in_alt) {
                            # het for ref and alt
                            $variant_seq = "$gt1,$gt2";
                        }
                        elsif ($gt2_is_ref && $gt1_in_alt) {
                            # het for ref and alt
                            $variant_seq = "$gt2,$gt1";
                        }
                        elsif ($gt1_in_alt && $gt2_in_alt) {
                            # het for 2 alts
                            $variant_seq = "$gt1,$gt2";
                        }
                        else {

                            # the genotype sequence isn't in the allele string

                            # first check if the classes match

                            my $gt_incl_indel = ($gt1 eq '-' || $gt eq '-');
                            my $vf_is_indel = ($vf->var_class eq 'deletion' || $vf->var_class eq 'insertion');

                            next GT unless $gt_incl_indel == $vf_is_indel;

                            my $vf_is_sub = $vf->var_class eq 'substitution';
                            my $gt_is_sub = (length $gt1 > 1) || (length $gt2 > 1);

                            next GT unless $vf_is_sub == $gt_is_sub;

                            # sometimes there are multiple genotypes at the same location,
                            # but this only seems to happen when the associated variation
                            # differs

                            next GT if ($gt->variation->name ne $vf->variation_name);

                            # otherwise sometimes the variations match, but the alleles
                            # don't match the genotype e.g. rs55844409 has allele string
                            # T/C but Watson has a G/G genotype. We suspect these are dbSNP
                            # bugs, but we still include them

                            $variant_seq = $hom ? $gt1 : "$gt1,$gt2";
                        }

                        $attrs->{Variant_seq} = $variant_seq;

                        $attrs->{Zygosity} = $hom ? 'homozygous' : 'heterozygous';

						my @variant_seqs = split ',', $variant_seq;
						my $index = 0;
						my %allele_index = map {$_ => $index++} @variant_seqs;
						my $genotype = $allele_index{$gt1} . ":" . $allele_index{$gt2};
						$attrs->{Genotype} = $genotype;
                        #$comment .= "real genotype: $gt1/$gt2"
                    }

                    unless ($attrs->{Zygosity}) {
                        # this vf isn't in this individual, so don't output it
                        next VF;
                    }
                }

                if ($population) {

                    # we're making a file for a population, so look up the alleles and their frequencies

                    my @vf_alleles = split /\//, $vf->allele_string;

                    my $found = 0;

                    my @alleles;
                    my @freqs;

                    if (my $allele_hash = $alleles_by_variation_id->{$vf->{_variation_id}}) {
                        for my $allele (keys %$allele_hash) {
                            my $freq = $allele_hash->{$allele};
                            if ($allele eq $vf_alleles[0]) {
                                $attrs->{Reference_seq} = $allele;
                            }
                            else {
                                push @alleles, $allele;
                                push @freqs, $freq;
                                $found = 1;
                            }
                        }
                    }

                    if ($found) {
                        $attrs->{Variant_seq}   = join ',', @alleles;

                        if (grep {$_ =~ /\d/} @freqs) {
                            $attrs->{Variant_freq}  = join ',', @freqs;
                        }

                        #warn $vf->to_gvf(extra_attrs => $attrs)."\n";
                    }
                    else {
                        next VF;
                    }
                }

                if ($include_failed || $just_failed) {

                    # we're including failed variations, so look up the description and add to the output

                    if (my $desc_id = $failed_ids->{$vf->{_variation_id}}) {
                        my $desc = $failed_descs->{$desc_id};
                        $attrs->{ensembl_failure_reason} = $desc;
                    }
                    else {
                        next VF if $just_failed;
                    }
                }

                # if we get here, we want this vf included in the dump, so convert
                # it to GVF including any extra attributes defined above

                $attrs->{ID} = ++$id_count;

                my $gvf_line = $vf->to_gvf(
                    extra_attrs             => $attrs,
                    include_consequences    => $include_consequences,
                    include_coding_details  => $include_coding_details,
                    include_global_maf      => $include_global_maf,
                );

                if ($id_count % 1000 == 1) {
                    #check_mem();
                }

                print GVF $gvf_line, ($comment ? " # $comment" : ''), "\n" if $gvf_line;
            } # end variation feature
        }

        if ($include_svs) {

            my $svfa = $vdba->get_StructuralVariationFeatureAdaptor;

            my $svfs = $svfa->fetch_all_by_Slice($sub_slice, 1);

            for my $svf (@$svfs) {

                # ignore CNV probes

                next if $svf->var_class eq 'CNV_PROBE';

                my $coords = join '-', $svf->seq_region_name, $svf->seq_region_start, $svf->seq_region_end;

                if (my $prev_coords = $prev_svs->{$svf->variation_name}) {
                    warn "repeated SV: ".$svf->variation_name." coords 1: $prev_coords, coords 2: $coords\n" if $prev_coords ne $coords;
                    next;
                }

                # we can now have SVs that map to multiple locations so we can't use the
                # feature's own identifier and we have to use a file-wide count as for
                # normal variations

                my $gvf_line = $svf->to_gvf(extra_attrs => {ID => ++$id_count});

                print GVF "$gvf_line\n" if $gvf_line;

                $prev_svs->{$svf->variation_name} = $coords if $gvf_line;
            }
        }
    }
}

close GVF;

if ($compress) {
    system("gzip -f $output_file") == 0 or die "Failed to gzip $output_file";
}

my $config = {};

# finds out memory usage
sub memory {
    my @mem;

    open IN, "ps -o rss,vsz $$ |";
    while(<IN>) {
        next if $_ =~ /rss/i;
        chomp;
        @mem = split;
    }
    close IN;

    return \@mem;
}

sub check_mem {
    eval q{use Devel::Size qw(total_size)};
    my $mem = memory();
    my $tot;
    $tot += $_ for @$mem;

    if($tot > 1000000) {
        $tot = sprintf("%.2fGB", $tot / (1024 * 1024));
    }

    elsif($tot > 1000) {
        $tot = sprintf("%.2fMB", $tot / 1024);
    }

    my $mem_diff = mem_diff($config);
    print "MEMORY $tot ", (join " ", @$mem),"\nDIFF ", (join " ", @$mem_diff), "\n";
}

sub mem_diff {
    my $config = shift;
    my $mem = memory();
    my @diffs;

    if(defined($config->{memory})) {
        for my $i(0..(scalar @{$config->{memory}} - 1)) {
            push @diffs, $mem->[$i] - $config->{memory}->[$i];
        }
    }
    else {
        @diffs = @$mem;
    }

    $config->{memory} = $mem;

    return \@diffs;
}

__END__

=head1 NAME

dump_gvf.pl

=head1 DESCRIPTION

Create GVF files from the variation databases

=head1 SYNOPSIS

dump_gvf.pl --species NAME [options]

=head1 EXAMPLE COMMAND LINES

  dump_gvf.pl --species mouse --registry ensembl.registry --include_failed

    dump all variation features, including failed variations, from the mouse
    database to the default mouse.gvf file

  dump_gvf.pl --species human --registry ensembl.registry --individual Watson \
    --seq_region 1 --seq_region 2 --output watson.gvf

    dump all variations, including genotypes, found in Watson's chromosomes
    1 & 2 to the watson.gvf file

  dump_gvf.pl --species human --population '1000GENOMES:low_coverage:CEU' \
    --output 1kg_pilot1_CEU.gvf --compress

    dump all variations, including allele frequencies, found in the specified
    population and then compress the file to 1kg_pilot1_CEU.gvf.gz

  dump_gvf.pl --species human --somatic --output human_somatic.gvf

    dump somatic mutations from human

=head1 OPTIONS

=over 4

=item B<--species NAME>

Fetch data for this species, accepts latin name, or any alias set up in your
registry file. This option is required.

=item B<--registry FILE>

Use database connection details from this registry file, will default to the
registry specified in the $ENSEMBL_REGISTRY environment variable if not
specified.

=item B<--output>

Dump GVF to the specified file. Defaults to <species_name>.gvf

=item B<--somatic>

Fetch somatic mutations rather than germline variations

=item B<--compress>

gzip the file when the dump has finished

=item B<--include_failed>

Include variations flagged as failed in the GVF file

=item B<--just_failed>

Only include variations flagged as failed

=item B<--include_consequences>

Include the consequences of variations on transcripts and regulatory regions etc.

=item B<--include_coding_details>

Include extra information for coding variations, including the amino acid alleles and any SIFT or PolyPhen predictions

=item B<--include_global_maf>

Include the global minor allele frequency information from dbSNP

=item B<--individual NAME>

Only include variations found in this individual, including genotypes if available.
B<NB> You can't specify an individual and a population at the same time.

=item B<--population NAME>

Only include variations found in this population, including allele frequencies if available
B<NB> You can't specify a population and an individual at the same time.

=item B<--set NAME>

Only include variations found in this variation set

=item B<--chunk_size NUM_KILOBASES>

Fetch features from slices this number of kilobases long to avoid excessive memory usage

=item B<--seq_region NAME>

Only include variations from this toplevel seq_region (normally chromosome name, e.g. 4 or X).
You can specify several seq_regions by repeating this option for each name.

=item B<--include_structural_variations>

Include structural variations in the output

=item B<--just_structural_variations>

Only include structural variations in the output

=item B<--help>

Display this documentation

=head1

For help with this script address questions to http://lists.ensembl.org/mailman/listinfo/dev

redpajama_set_name: RedPajamaGithub


text:
Bach to run unopposed for IOC president
LONDON, ENGLAND – JULY 27: Fireworks ignite over the Olympic Stadium during the Opening Ceremony for the London 2012 Olympic Games on July 27, 2012 at Olympic Park in London, England. (Photo by Jamie Squire/Getty Images)
Lausanne (Switzerland), Dec 1 (IANS) The International Olympic Committee (IOC) said on Tuesday that president Thomas Bach will stand unopposed in the presidential election that is scheduled for March next year. The election is set to be held at the IOC Session in Athens scheduled for March 10 to 12.
The German's new term begins after the postponed Tokyo Olympics, which is scheduled to be held from July 23 to August 8, and he will stay in the position until 2025.
"The members of the International Olympic Committee were informed today on behalf of the IOC Ethics Commission's Chair, HE Ban Ki-Moon, by IOC Chief Ethics and Compliance Officer Paquerette Girard Zappelli that President Thomas Bach will be the only candidate for the presidential election, which will be held during the 137th IOC Session in Athens in March 2021," said the IOC in its statement.
A former Olympic fencer who won gold at the 1976 Montreal Olympics, Bach, 66, first took charge on September 10, 2013. His unopposed re-election was all but confirmed after more than 50 members publicly supported his candidacy at its annual board meeting in July.
Mumbai looking to maintain momentum against East Bengal
Goa draw 1-1 with NorthEast, search for win continues


text:
Home » News » Death Proof and Planet Terror arrive in high definition this winter
Death Proof and Planet Terror arrive in high definition this winter
Posted on October 3, 2008 by Guido Henkel in News // 0 Comments
Genius Products has just added Blu-Ray Disc versions of the Grindhouse films Death Proof and Planet Terror to their winter release line-up.
Director Quentin Tarantino delivers an adrenaline shot to the heart with Death Proof, that features exhilarating high-speed action, jaw-dropping stunts, and some of the most quotable lines since "Pulp Fiction." Kurt Russell stars as a sociopathic stuntman whose taste for stalking sexy young ladies gets him into big trouble when he tangles with the wrong gang of badass babes. Their confrontation escalates to a hair-raising, 18-minute automotive duel with one of the girls strapped to the hood of a thundering Dodge Challenger.
The release will feature the extended and unrated cut of the film in a 1080p high def transfer with Dolby Digital audio. Expect to see all the extras from the DVD version to make their way to this high definition version also.
In Planet Terror, director Robert Rodriguez returns to the horror genre with a rip-roaring, zombie-infested rollercoaster of a movie. Rose McGowan, Freddy Rodriguez, Bruce Willis, and an all-star cast fight for their lives in the ultimate showdown between an army of flesh-eating mutants and a motley group of rag-tag survivors. Featuring one of the most memorable screen heroines ever and the now-legendary mock Machete trailer.
This film will also be released in an extended and uncut version in 1080p high definition, complemented by a Dolby Digital audio track. Coming as a 2-disc set, all the extras from the DVD version will also be carried over, making this one an exciting release to look forward to.
"Death Proof" and "Planet Terror" will make their Blu-Ray debuts on December 16. "Death Proof" will carry a $28.95 sticker price, while the 2-disc Blu-Ray set of "Planet Terror" will cost $34.95.


Jessica Harmon as Dale, Malcolm Goodwin as Clive.
iZombie is a busy show, which makes it easy to lose track of the many plates it spins at any given moment. But this week, as the season comes to a close, there's no case of the week and no real subplots. "Dead Beat" is squarely focused on one thing: saving Major.
After Ravi explains to Liv the whole truth about Major, they start looking for a way either to get him out of prison or to get brains in. First, they figure out where Major was hiding the frozen zombies, since Major's case will be cleared if just one of his alleged victims reappears. Unfortunately, all of the freezers are empty. Someone got there before they did. Props to Rose McIver for selling just how discouraged Liv feels in that moment.
The obvious culprit is Vaughn Du Clark, who has been keeping tabs on Major. He hires Brant Stone (Ken Marino), a skeezy defense lawyer who loves hitting on Peyton, to defend Major. Vaughn also lands a deal to sell SuperMax to a private military contractor; however, the deal is contingent on the public not believing the Chaos Killers' murders were caused by the drink. So, Vaughn decides it's finally time to kill Liv and Major.
"Dead Beat" also spends a lot of time with Clive and Dale. It's been awhile since we really checked in on their relationship, and it's nice to see Clive playfully comforting her as she stresses about not having enough evidence to lock down the case. Though Dale is stonewalled, Clive makes some big headway with the Meat Cute murders. An inmate saw Major's picture on TV and tells Clive he sold Major the guns that were used in the killings.
Meanwhile, Brant manages to get Major out on bail, and Liv and Ravi are waiting outside the courthouse with a brain shake waiting for him. Channeling his inner Penguin, Vaughn's henchman Janko is also there with an umbrella hiding a retractable knife. However, both plans are foiled when Clive shows up to arrest Major for the Meat Cute murders.
At this point, Major is feeling hopeless enough to ask Liv for the cure. She refuses because she doesn't want him to lose his memory. But what other options do they have? They're going to lose him either way. Liv tries one more plan to get Major some brains, which involves baking a brain candy bar and getting Peyton to seduce Brant into passing it to Major. This plan fails, too, because Brant's dog eats the bar.
And that's where "Dead Beat" does such a good job. By slowly narrowing Liv's chances to save Major, the situation becomes increasingly desperate. As the episode goes on, it becomes clear that there's only one remaining choice: the truth.
Liv pays Clive a visit at home and tells him everything. Zombies and all. Obviously, Clive doesn't believe her at first. So, Liv stabs herself with a knife to prove she's a zombie. The entire season has been inching toward this point, and now that it's finally arrived, the episode slows down. It's a savvy move, giving this important scene enough space to breath and sink in. It mostly succeeds, too. I still kind of wish Clive would've pieced it all together on his own, but it makes sense for Liv to come clean in this moment. It's an important step for her. iZombie is about Liv recovering from the trauma of becoming a zombie. It's about her attempts to reaffirm her humanity to herself, while learning how to trust again.
Now that he knows everything — and believes it — Clive helps destroy both cases. Major is set free. However, saving Major's life and preventing the zombie apocalypse comes with a price. Clive's relationship with Dale is officially finished. She's pissed after realizing he's the one who sabotaged the cases, and when he refuses to explain why, she leaves him. (Her last words to him: "Good-bye, Clive.") This scene, in particular, reminded me that Malcolm Goodwin's strong performance isn't lauded nearly enough. His acting in this scene, combined with those cute flirty moments from earlier in the episode, make this breakup pretty heartbreaking.
But Liv and company aren't out of the woods just yet. Janko finds her alone in the morgue and drugs her — luckily, Ravi arrives before he can kill her. During their struggle, Ravi accidentally injects Janko with a full dose of the drug he used on Liv. The henchman is dead. Janko's death leaves Ravi visibly shaken. Liv does finds one bright side, though: She can eat Janko's brain to find out where the other zombies went.
Liv and Ravi return to her apartment, where Major, running on musician brains, is drumming away. The scene feels a bit too joyous after Ravi just, you know, killed a guy, but I'll give iZombie the benefit of the doubt and assume they'll deal with in the season finale. Suddenly, Major's incessant drumming causes Liv to flash. She sees Drake and the rest of the now-defrosted zombies locked in the basement of Max Rager.
"Dead Beat" briefly checks in with Blaine: His memory still hasn't come back, he's still nice, and he's still taking orders from Don E, which is very weird to see.
How will Clive's sabotage of the Chaos Killer and Meat Cute cases affect his standing within the SPD? Dale surely won't tell people that Clive did it, but the fact that two high-profile cases fell apart on his watch can't be good.
In exchange for smuggling the candy bar to Major, Peyton agrees to get drinks with Brant at a bar of his choosing … and she must have two drinks, minimum.
In case anybody forgot: The finale has to deal with Vaughn and Mr. Boss. That's a lot to handle for a single episode. Let's hope iZombie can pull it off.


text:
featuring dynamite and unfolding before thousands of picnicking spectators, eager to witness justice. While the criminals themselves are certainly fascinating, equally so are Rirette Maîtrejean and Victor Kibaltchiche, young lovers caught up with the wrong crowd and arrested and tried under France's "scoundrel laws," which ensured harsh punishments for criminal collaborators. In addition to his vivid portrayals of the principal characters and events, the author provides informative context to the crimes, outlining the severe exploitation of workers in this supposedly idyllic time in Parisian history.
This is a nuanced and fascinating dissection of the events by a riveting storyteller with a sympathetic (but unsentimental) view of the anarchists' cause. (Oct.)
Birding Without Borders: An
Obsession, a Quest, and the
Biggest Year in the World
Noah Strycker. Houghton Mifflin Harcourt, $27
Strycker (The Thing with Feathers), a birder and adventurer, chronicles the record-setting year he spent trekking the globe, succeeding in his aim "to see 5,000 species of birds—about half the birds on Earth—in the ultimate round-the-world journey." He begins in Antarctica on Jan.
1, 2015, and ends on December 31 in Australia, traveling to every continent and spotting more than 6,000 species.
Strycker traces his lifelong interest in ornithology to his Pacific Northwest childhood and a fortuitous set of bird-related events that took place in his life at age 10. In this volume Strycker tracks what he saw during his "big year" and describes his planning process and the ground rules he established. Every bird he counted, for example, would need to be "seen by at least one other person." His companions had to be local, too, "living in the same country where we went birding together." This would prevent loneliness on his solo trip and help to give him the inside scoop. Even readers who wouldn't know a marvellous spatuletail from a southern ground hornbill will be awed by Strycker's achievement and appreciate the passion with which he pursues his interest. Photos. Agent: Russell Galen, Scovil Galen Ghosh Literary. (Oct.)
Dennis Maruk: The Unforgettable
Story of Hockey's Forgotten
60-Goal Man
Dennis Maruk, with Ken Reid. ECW (Legato, U. S. dist.; Jaguar, Canadian dist.), $25.95
(200p) ISBN 978-1-77041-331-3
Fast-moving and short could describe both Maruk and his memoir. At five feet eight, the Toronto native entered the NHL in the 1975–1976 season with the lowly California Seals. As an 18-year-old rookie, he wasn't expected to make the team, but he took the advice of NHL player Dave Hutchison to "be a prick" on the ice to heart, sporting a Fu Manchu mustache to help him look and feel tougher. His entire career, aside from two stints in Minnesota, was spent playing for teams based in Oakland, Washington, D.C., and Cleveland, cities where it was hard to sell hockey. "I was a guy who played for teams that just couldn't put fans into seats," he laments. Written with broadcaster Reid (Hockey Card Stories), the book is cleverly divided into 60 chapters to reflect Maruk's achievement of 60 goals in a season, though that often means that sections are brief and end abruptly.
Maruk writes honestly about his failed marriages, his battles with depression, and his difficulty finding a posthockey life, and there's enough insight into the business side of the game (including the bizarre merger of the Barons and North Stars), his teammates, and on-the-road hijinks to please any hardcore hockey fan.
Agent: Brian J. Wood. (Oct.)
Fire on the Track: Betty Robinson
and the Triumph of the Early
Olympic Women
Roseanne Montillo. Crown, $27 (304p)
Against the backdrop of the Great
Depression, Montillo (The Wilderness of
Ruin) traces the fascinating story of Betty
Robinson, an Olympic-track-and-field
trailblazer. Montillo is a brilliant story-
teller who introduces Robinson in 1931,
as she is being driven to a local funeral
home, assumed dead, after a devastating
plane crash that puts her life—and future
Olympic hopes—in jeopardy. As a high
school athlete, Robinson came just a tenth
of a second short of the U.S. indoor track
record. Robinson went on to join the first
female track-and-field team to compete in
the 1928 Olympics and won gold for the
U.S. In telling Robinson's story, Montillo
ably traces women's fight for inclusion
and equality in competitive sports while
unearthing decades-old examples of the
biases and challenges women in competi-
tive sports still face to this day (some
detractors claimed that the Olympics
were creating " 'manly' women"; others
questioned an athletic woman's gender).
Montillo also includes riveting portraits of Tidye Pickett and Louise Stokes—the first female African-American runners. Montillo has written an engaging, insightful look at an era in women's sports. (Oct.)
Future War: Preparing for the
New Global Battlefield
Robert H. Latiff. Knopf, $25 (208p) ISBN 978-
Latiff, a retired U.S. Air Force general with a background in military weapons systems, emphasizes the need to understand the moral and ethical dimensions of the development of sophisticated military technologies and to craft policy with the potential dilemmas these technologies could cause in mind. He cautions that technology is addictive and seductive, and that human societies have a history of developing technologies without adequately thinking about the consequences.
Latiff sees future wars being fought largely by armies of robots; humans will play a part in future war, but it will increasingly be through remote control.
He also believes that new technologies will affect future soldiers, who will be isolated from their wider societies and biologically enhanced to be stronger, faster, and smarter than their nonmilitary peers. The nature of the future battlefield and warrior, he contends, will make war more brutal than ever. Latiff states that education, understanding, and expertise on military matters and science must be shared by all segments of society, particularly by the U. S. civilian population, media, and political leadership, as a bulwark against the relentless tide of technological advancement. This is a quick and stimulating read, and its focus on ethics makes it an important part of the growing literature related to managing the continuing acceleration of technological development. (Oct.)


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Home / Arcade, PC Classics, Sports / California Games
Arcade PC Classics Sports Arcade Games 13 Mar , 2018 0
About California Games
California Games is classic arcade sports game by Epyx sports released in 1987 for a number of home computers and game consoles. The game consisted of some sports popular in California including surfing, skateboarding, freestyle footbag, roller skating, frisbee (flying disc) and BMX-ing. Originally released for the Apple II and Commodore 64, this game was a great success for Epyx and was released on many other platforms over the coming years, including the Amiga, Apple IIGS, Atari 2600, Atari ST, Atari Lynx, DOS, Sega Mega Drive, Amstrad CPC, ZX Spectrum, Nintendo Entertainment System, MSX and Sega Master System.
International Karate +


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Q: Allow arbitrary loads with Xcode 8 Is there a way for me to enable Allow Arbitrary Loads with Xcode 8? There no longer seems to be a info.plist option that makes this possible. Plus with the removal of the NSData types its all a little confusing.

A: Don't worry buddy.
When you pass the mouse in the plist you will see a plus symbol

Any doubt you just ask here.

redpajama_set_name: RedPajamaStackExchange