2017 is wrapping up quickly, and it is time to think about the coming year. I look at New Year's resolutions differently than most. I prefer to set goals. Goals that are planable, trackable, and measurable. Yes, that's a lot of -ables. Yes, I made one up.
The bottom line is that I am a huge goal setter. I am excited to be mixing it up a bit and doing it differently this year. Usually I plan out some rather lofty goals for myself each year, and I work at them rather diligently… for awhile. Much like my personality, I tend to switch gears when I get bored with something or just lose the required energy to sustain a project. I am sure many of you get my drift!
So this year, I have decided to set monthly goals. Each month of the year I will focus on one goal. Of course I always have a lot of embers burning in the fire, but this one goal will be my main focus for the entire month. And get this… I am not planning out all 12 monthly goals right now. Nope, not doing it. Because really, who is to say what I will be feeling come August or even April? Nope, I am only setting one goal right now for the month of January. I do have other ideas that I may choose to focus on with my other 11 months of goals, but for right now what I need most is to focus on my January goal.
My January goal for 2018 is to cut out all added sugar.
I am calling it my Sugar-Free January. So what exactly does Sugar-Free look like? Depending on your diet it could mean different things. For me, it means to cut out all refined and added sugar. It also means to limit food items that act like sugar according to the Glycemic Index.
The easiest way to do this is to eat whole foods and stay away from processed foods. I admit my last two weeks of teaching had me grabbing a frozen meal each day to take to work for lunch. If I don't pack a lunch, I do not eat. With the busyness of work and prepping for the holidays, I simply resorted to frozen meals for lunch. While I feel like I made healthier choices, I don't feel like that is the best daily option for me.
When resorting to processed or prepared foods I will not use a food item if sugar (or a form of sugar) is listed in the first five ingredients. This means double checking the peanut butter label and preparing all my own salad dressings and tomato sauces.
You might think that this means that the month of January will also be dessert free, that is really just a mind set change. A bowl of fresh fruit can serve as the perfect dessert. One thing I will need to think about is the glass of wine that I enjoy with dinner. While wine does not have added sugar, the grapes as they ferment create residual sugar in the wine. Red wine tends to have less sugars than white, and lucky me I prefer the reds in the winter months. For now I am not setting a hard and fast rule in regards to alcohol. With the holidays behind us, I am not worried about upcoming parties and alcohol consumption. I do know that If I choose to drink a glass of red wine with dinner, it will be one glass and only a few times each week.
My goal is to cut out as much sugar as possible without feeling completely deprived. It is about building a lower-sugar sustainable lifestyle. It's about breaking my sugar cravings. It is about eating healthier and feeling better.
If you are interested, you can join me in making January a sugar-free month! I feel like the more we bind together in our shared goals, the more successful we will be. To help all of us, I will be sharing a few recipes and menu ideas to help us all lower the sugar consumption in our life.
I can guarantee that after 31 days of living sugar-free or nearly sugar free – I will be feeling a whole lot better!


Air-conditioned room features direct access to the pool. Includes a private balcony with garden views and an en suite bathroom.
Suite room with private pool in golf course view.
This single room has a balcony, tile/marble floor and minibar.
Spacious suite features a sofa seating area. Includes a private balcony with garden views and an en suite bathroom.


Sir, I have quarrelled with my wife; and a man who has quarrelled with his wife is absolved from all duty to his country.
I don't get any money from my wife.
I've got more clothes than my wife.
My wife is very competitive, as the others are. We enjoy that.
My wife thinks I'm completely mad.


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Interleukin-18, From Neuroinflammation to Alzheimers Disease
Author(s): Paola Bossu, Antonio Ciaramella, Francesca Salani, Diego Vanni, Ilaria Palladino, Carlo Caltagirone, Giuseppe Scapigliati. IRCCS Fondazione Santa Lucia, Department of Clinical and Behavioral Neurology, Experimental Neuro-psychobiology Lab Via Ardeatina, 306, I-00179 Roma–Italy., Italy
Journal Name: Current Pharmaceutical Design
A large body of evidence on brain development and ageing has revealed that inflammatory processes profoundly affect brain functions during life span of mammalians, including humans. Activation of innate immune mechanisms leading to pro-inflammatory cytokine up-regulation is involved in devastating and disabling human brain illnesses, as Alzheimers disease (AD), a progressive neurodegenerative disease that causes dementia in the elderly. Emerging data indicate that the cytokine Interleukin (IL)-18, one of the key mediator of inflammation and immune response, has relevance in the physiopathological processes of the brain, by ultimately influencing the integrity of neurons and putatively contributing to AD. In this review, the relationship between specific IL-18-mediated processes and AD neurodegeneration is summarized and clinical studies pointing to a role of the cytokine in the pathology are discussed. Altogether, the presented data indicate that a more complete knowledge of the molecular mechanisms underlying IL-18 implication in neuroinflammatory and neurodegenerative pathways could contribute toward the development of new therapeutic strategies for AD.
Keywords: Interleukin-18, Alzheimer's disease, neuroinflammation, cytokines
Title: Interleukin-18, From Neuroinflammation to Alzheimers Disease
Author(s):Paola Bossu, Antonio Ciaramella, Francesca Salani, Diego Vanni, Ilaria Palladino, Carlo Caltagirone and Giuseppe Scapigliati
Affiliation:IRCCS Fondazione Santa Lucia, Department of Clinical and Behavioral Neurology, Experimental Neuro-psychobiology Lab Via Ardeatina, 306, I-00179 Roma–Italy.
Keywords:Interleukin-18, Alzheimer's disease, neuroinflammation, cytokines
Abstract: A large body of evidence on brain development and ageing has revealed that inflammatory processes profoundly affect brain functions during life span of mammalians, including humans. Activation of innate immune mechanisms leading to pro-inflammatory cytokine up-regulation is involved in devastating and disabling human brain illnesses, as Alzheimers disease (AD), a progressive neurodegenerative disease that causes dementia in the elderly. Emerging data indicate that the cytokine Interleukin (IL)-18, one of the key mediator of inflammation and immune response, has relevance in the physiopathological processes of the brain, by ultimately influencing the integrity of neurons and putatively contributing to AD. In this review, the relationship between specific IL-18-mediated processes and AD neurodegeneration is summarized and clinical studies pointing to a role of the cytokine in the pathology are discussed. Altogether, the presented data indicate that a more complete knowledge of the molecular mechanisms underlying IL-18 implication in neuroinflammatory and neurodegenerative pathways could contribute toward the development of new therapeutic strategies for AD.
Paola Bossu, Antonio Ciaramella, Francesca Salani, Diego Vanni, Ilaria Palladino, Carlo Caltagirone and Giuseppe Scapigliati, " Interleukin-18, From Neuroinflammation to Alzheimers Disease", Current Pharmaceutical Design (2010) 16: 4213. https://doi.org/10.2174/138161210794519147
Combining Neuropsychological and Structural Neuroimaging Indicators of Conversion to Alzheimers Disease in Amnestic Mild Cognitive Impairment
Exploration of Various Proteins for the Treatment of Alzheimer's Disease
Current Drug Metabolism
Treatment of Mild Cognitive Impairment (MCI)
Novel Neuroendocrine and Metabolic Mechanism Provides the Patented Platform for Important Rejuvenation Therapies: Targeted Therapy of Telomere Attrition and Lifestyle Changes of Telomerase Activity with the Timing of Neuron-Specific Imidazole-Containing Dipeptide-Dominant Pharmaconutrition Provision
Is High Oral Dose L-arginine Intake Effective in Leukoaraiosis? Preliminary Data, Study Protocol and Expert's Opinion
Current Aging Science
The Early Involvement of the Innate Immunity in the Pathogenesis of Lateonset Alzheimers Disease: Neuropathological, Epidemiological and Genetic Evidence
Effects of Music Therapy on Psychological Symptoms and Heart Rate Variability in Patients with Dementia. A Pilot Study
Vitamin D Increases Aβ140 Plasma Levels and Protects Lymphocytes from Oxidative Death in Mild Cognitive Impairment Patients
Neurotrophic Factors as a Protective Strategy in Parkinsons Disease
Crosstalk between Gut Microbiota and Central Nervous System: A Focus on Alzheimer's Disease
Depressed or Demented: Common CNS Drug Targets? !
Current Drug Targets - CNS & Neurological Disorders
Alzheimers Disease-Associated Neurotoxic Mechanisms and Neuroprotective Strategies
Protein Conformational Pathology in Alzheimers and Other Neurodegenerative Diseases; New Targets for Therapy
Herbal Medicines for the Prevention and Treatment of Alzheimer's Disease
A New Decision Tree Combining Abeta 1-42 and p-Tau Levels in Alzheimer's Diagnosis
Progression of Mild Cognitive Impairment to Alzheimers or Vascular Dementia Versus Normative Aging Among Elderly Chinese
The Treatment of Behavioral and Psychological Symptoms of Dementia: Weighing Benefits and Risks
New Approaches in Nuclear Medicine for Early Diagnosis of Alzheimers Disease
Hormones in the Mentally Disturbed Brain: Steroids and Peptides in the Development and Treatment of Psychopathology
The Therapeutical Potential of Alpha-Synuclein Antiaggregatory Agents for Dementia with Lewy Bodies

redpajama_set_name: RedPajamaCommonCrawl


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Hobbservation Point
The N-word is not the litmus test for racism
Chuck Hobbs August 16, 2018 August 16, 2018 Uncategorized
"Nigger" is as polarizing a word as there is in the English lexicon. It is a word that was used by ignorant southern planters who lacked formal lessons in Latin to properly pronounce "niger," the Latin word for black. It is a word that rolled off of the tongues of southern slave owners and white overseers as they worked men, women and children literally to death in the hot southern sun. It is a word that white men used as they raped and defiled black women during slavery and the years that followed under Jim Crow. It was the last word that many Black men, women and children heard before they were brutally lynched to death by white mobs. It was the word that defiant southerners hurled as peaceful civil rights activists marched, sat-in and demanded equal justice during the 1950s and 60s. It is a word that somewhat went underground in the public square among whites in the late 1960s, as the late Lee Atwater, a prominent Republican strategist infamously described in 1981:
"You start out in 1954 by saying, 'Nigger, nigger, nigger.' By 1968 you can't say 'nigger'—that hurts you, backfires. So you say stuff like, uh, forced busing, states' rights, and all that stuff, and you're getting so abstract. Now, you're talking about cutting taxes, and all these things you're talking about are totally economic things and a byproduct of them is, blacks get hurt worse than whites…'We want to cut this' is much more abstract than even the busing thing, uh, and a hell of a lot more abstract than 'Nigger, nigger.'
Today, no white politician worth his salt will say "nigger" in public, but as Atwater averred above, they do not have to because their actions betray their deeply held racial biases. Such biases are held by politicians in BOTH parties, mind you, as the net effect of those white Democrats (and sycophantic black colleagues) in Congress, and the Clintons who supported the 1994 Crime Bill that incarcerated mass numbers of black men that Hillary Clinton called "Super-Predators," was immense. This despite the fact that those black street corner dealers, gang members and users served more time than the whites who imported said drugs from South America and Afghanistan (or used said drugs in their corporate and political offices and suites). Indeed, such served as the blueprint for the Trump administrations current push to roll back Obama era sentencing reforms by demanding tougher sentencing–even up to the death penalty–for drug distribution. As such, "Super-Predator" or talks about "Black on Black Crime" are synonyms for "nigger" and far more detrimental than the mere statement of the word.
I remind of these facts because I find it astonishing that on the major news networks, the question this week has been whether former Trump aide Omarosa Manigault Newman has tapes of President Trump saying what journalists have now reduced to calling "the N-word." I, for one, do not need a tape to know that Trump, a 72-year old New Yorker who grew up privileged and away from black people, has said the word in the past. Hell, I suspect that Trump has either mumbled it to himself or among his cronies multiple times just this past week.
But it may shock some to read this but I submit, so what if Trump has used the word, what does such prove that we do not already know about him? Consider for a moment that former President Lyndon Johnson reportedly used the N-word as often as he would say hello, but history remembers him for signing the Civil Rights Act and Voting Rights Act into law. To that end, whether Trump hurls racial epithets in private pales in comparison to the coded language that he uses on a daily basis on Twitter, at his political rallies, and in his policy perspectives. One need not hear tapes of Trump using the N-word to know that he has a lifetime of being sued for racial discrimination in his businesses, or his racist advocacy for the death penalty for the five young black men falsely convicted of raping a white woman in Central Park in the 1980s, or what drove him to to political fame this decade, which was his racist insistence that former President Barack Obama was not an American citizen.
While Trump's racism denying defenders suggest that he merely "punches back" when he is attacked, a recent analysis of Trump's Twitter page has revealed that the president has used the words "dumb" or "low IQ" 73 percent of the time to describe a black person with whom he disagreed, and only 27 percent of the time against white opponents. Lest we forget that one of the more common racist slights in ages past was the idea that blacks were intellectually inferior to whites.
So, when Trump makes such slights against blacks, he is no different from typical racists of yore. Which is curious when considering that with a nod to the late soul singer Sam Cooke, Trump routinely shows that he "don't know much about history," or spelling, syntax, subject-verb agreement, the political processes and separation of powers, either. Still, for those who think that the determination of whether Trump has racist tendencies boils down to whether he has ever said the N-word, those among us are willfully blind or simply have not been paying attention to his actions.
Previous The Dallas Cowboys morph from "America's Team" to the neo-Confederacy's team
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Published by Chuck Hobbs
A man blessed with a keen analytical mind, razor sharp wit and one very trenchant pen...	View all posts by Chuck Hobbs


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Q: Método C# uso de SSH.NET problemas en al añadir strings a un fichero Estoy haciendo un método en C# que añada información a un fichero que se encuentra en una máquina con Ubuntu Server. Para ello estoy haciendo uso de SSH.NET . En modo debug si lo voy ejecutándolo paso a paso todo funciona correctamente, el problema surge cuando lo ejecuto "de seguido", en el fichero "logFile" sólo se añaden algunas líneas, para ser exactos sólo segunda componente del array de strings.
   public static void ExecSSH(string pServidor, string pUsuario, string pPassword, string[] changes)
    {
        try
        {
            using (var client = new SshClient(pServidor, pUsuario,pPassword))
            {
                client.Connect();
                //Necesario para hacer acciones de super usuario
                ShellStream shellStream = client.CreateShellStream("xterm", 80, 24, 800, 600, 1024);
                var output = shellStream.Expect(new Regex(@"[$>]"));

                //Obtener privilegios de super usuario"
                shellStream.WriteLine("sudo su");
                output = shellStream.Expect(new Regex(@"([$#>:])"));

                //Comprobación por si ya se estaba en modo Super usuario
                if(output.IndexOf("password") != -1)
                {
                    //Si no se estaba en super usuario se introduce la contraseña
                    shellStream.WriteLine(pPassword);
                }
                //Crear fichero de log si no se ha creado antes
                shellStream.WriteLine("touch /var/log/asterisk/" + logFile);
                //Cambiar los permisos para que cualquier usuario pueda modificar el fichero
                shellStream.WriteLine("chmod 646 /var/log/asterisk/"+ logFile);

                //Recorrer array de strings para añadir cada componente en una linea del fichero
                for(int i = 0; i < changes.Length; i++)
                {
                    //Cambia los $ que haya en las strings para que los reconozca
                    string valuechange = changes[i].Replace("$","\\$");

                    //Añadir ese componente del array en una linea del fichero

                    shellStream.WriteLine("echo " + valuechange + " >> " + "/var/log/asterisk/" + logFile);

                }
               client.Disconnect();
            }
        }
        catch (Exception ex)
        { throw ex; }
    }

He estado googleando y no encuentro qué es lo que puede estar pasando. No sé si puede ser que al servidor no le da tiempo a ejecutar un comando de bash cuando ya le llega el siguiente comando, pero me parece demasiada coincidencia que siempre se añada sólo la segunda componente del array de strings.
Este es el posible contenido del array de strings:
string[] change_log = { "\"["+stimenow+"]\"", "\"Category: " + category + "\"", "\"Line: " + line + "\"", "\"LastValue: " + lasvalue +"\"", "\"NewValue1: " + newvalue1 + "\"", "\"NewValue2: " + newvalue1 + "\"" };

(Todas las variables de las que depende son strings)

redpajama_set_name: RedPajamaStackExchange


text:
Home Politics Foreign Politics North Korea + Iran Vs World
North Korea + Iran Vs World
Collaboration between North Korea and Iran has a long and well-outlined history.
The common will to grow politically and strategically in the world, has pushed them to a profound technological and strategic collaboration.
We must not be surprised, therefore, that the most developing sectors have been armaments and cyber warfare.
In the 2011 , China blocked publication of another damning UN report which said the North almost certainly has more undisclosed enrichment-related facilities.
It went on to voice concerns that North Korea might "transfer fissile materials or the means of producing them" to foreign countries — such as Iran.
Iranian delegations have visited North Korea in the past to observe missile tests and exchange technology.
This newest UN report, buried by China, affirms U.S. concerns about Chinese willingness to look the other way when it comes to North Korean nuclear activities.
Diplomatic cables published through WikiLeaks show that the U.S. has repeatedly importuned Beijing to bar North Korean shipments through China, yet China has taken no action.
The Cylance cyber security firm published a report concluding that Iranian hackers have attacked critical infrastructure and government agencies in 16 countries since 2012.
The Iranian campaign may be linked to North Korea's own campaign that is dominating headlines in the U.S.
"[Iran's] intense focus on critical infrastructure companies, especially in South Korea, hints at information sharing or joint operations with Iran's partner, North Korea.
In September, 2012, Iran signed an extensive agreement for technology cooperation with North Korea, which allows for collaboration in a variety of efforts including IT and security," it states.
The study noticed similarities between Iranian and North Korean operations and warned that the Iranian attackers retrieved highly sensitive information about airports and airlines in South Korea, Saudi Arabia and Pakistan.
They even had the ability to remotely control security gates and systems. Nine oil companies were also penetrated.
A secret FBI document warns that the Iranian cyber campaign is targeting U.S. universities, defense contractors and energy companies.
The most well-known attack was on a Las Vegas casino after its owner urged tougher threats to Iran, suggesting a nuclear detonation in an Iranian desert as an option.
The hackers left a message on the casino computers making it clear that it was retaliation for the comment.
Supreme Leader Khamenei responded angrily to the remark.
In 2012, the Iranian regime launched cyber attacks on the Saudi Aramco oil company and replaced all computer data with images of burning American flags.
The hackers said it was retaliation for Saudi support for the Bahraini government when it put down a largely Shiite uprising.
The attack damaged 30,000 computers and intended to disrupt oil and gas deliveries. Iranian hackers then struckthe RasGas natural gas company in Qatar.
Iran has repeatedly condemned Qatar for supporting Syrian rebels.
U.S. officials have confirmed that North Korea is behind a cyber attack on the Sony Corporation that released troves of sensitive data in retaliation for a comedy film titled "The Interview" about an assassination plot against North Korean dictator Kim Jong-Un.
The hackers threatened 9/11-style attacks on movie theaters showing the film and to release more internal data from Sony on Christmas when the movie is released.
Major movie theaters chains cancelled plans to show the film and Sony subsequently canceled the film's release, even on DVD.
Another planned movie with a thriller story line based in North Korea was canned, even though the hackers never even mentioned it.
The appeasement is reminiscent of Comedy Central's decision to censor all images of the Prophet Mohammed in its South Park animated show because of Islamist terror threats.
The attack on Sony bears strong similarities to Iran's attacks on Saudi Aramco in 2012, indicating that the Iran and North Korea's cyber warfare programs are interconnected and there may have even been coordination.
Just like their weapons of mass destruction programs, the Iranian and North Korean cyber warfare programs should be treated as one entity.
The Iranian cyber campaign has been going on for years and is ongoing.
The lack of a response not only encourages Iranian aggression further, it likely encouraged North Korea to believe it could do the same with impunity.
North Korea and Iran do have a history of joint missile development dating back to the Iran-Iraq war in the 1980s, and both countries have been linked to Pakistani nuclear physicist and accused proliferator Abdul Qadeer Khan in the past.
Since that time, Iran has made some independent developments in its missile capability, but much of its progress has been coupled with assistance from Pyongyang, according to Bruce Bennett, a senior researcher who specializes in North Korea at the RAND Corporation.
Iran currently possesses more ballistic missiles than any other country in the Middle East but remains dependent on foreign suppliers for missile development and production — an ongoing challenge that raises questions about whether they can or will develop an ICBM capable of carrying a nuclear missile, according to the Nuclear Threat Initiative, a nonpartisan, Washington-based nonprofit organization.
The North Korean and Iranian nuclear and ballistic missile programs should be seen as a single entity, as should be their shared cyber warfare programs.
The advance of one is an advance of the other. Differences in their activity should be seen as a common-sense division of labor.
Gordon Chang, a prominent expert on Asian affairs, has written about the likelihood that this is the case.
Last May, an Iranian opposition group that has accurately identified hidden nuclear sites in the past reported that it had specific intelligence about North Korean nuclear and missile experts secretly visiting Iran.
Intelligence analyst Ilana Freedman said in January 2014 that her sources said a relocation of major parts of Iran's nuclear program to North Korea began as early as December 2012.
For Iran, it is best to let the North Koreans put the finishing touches on the most provocative nuclear and missile work. Whereas the Iranian regime does suffer from sanctions and must always keep the 2009 Green Revolution in the back of its mind, North Korea thrives off isolation and international provocation.
North Korea has nothing to lose and can only gain by such an arrangement. Kim Jong-Un's regime has already crossed the nuclear pariah threshold, so it might as well let its Iranian allies take the lucrative deal offered by the West.
It has been content to spend $1.1-$3.2 billion each year on it. Plus, the deal puts Iran in a more advantageous position and its economic improvements can help it invest more in North Korea's activity.
The good news is that this latest test—North Korea's fourth— does not appear to be more powerful than its last one, indicating no significant advance in technology. RAND Corporation analyst Bruce Bennett saysNorth Korea is still working on the "basics" of a nuclear fission bomb.
It is hard for some to accept that an Islamist theocracy like that in Iran would work with a cultish communist dictatorship like North Korea, but there is nothing in either one's ideology that would prevent such cooperation. In fact, North Korea's success in building a nuclear arsenal actually encourages Iran to see nuclear weapons as a key lesson for the Islamic Revolution.
"The entire world may well consider North Korea a failed state, but from the view point of [Iran], North Korea is a success story and a role model:
A state which remains true to its revolutionary beliefs and defies the Global Arrogance," Ali Alfoneh, an expert on the Iranian regime, told the Washington Free Beacon.
Given the spotty record of U.S. intelligence assessments (to say the least), the West must operate under the assumption that there isn't an Iranian WMD problem and a North Korean WMD problem, but an Iranian-North Korean WMD problem.
Previous articleSuper non Nuclear Bomb – USA Vs Russia
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I spent the last weekend doing fun things, including going to the Alternative Press Fair on Saturday. Seeing as I never make it out to North West London, I took the chance to hit some charity shops while I was there and found this Beth Ditto for Evans dress in one! I've been stalking these on eBay for YEARS, but they always go for lots and my budget is pretty non-existent, so I was pretty excited to find it for £8.99. Hurray thrifting!
On a side note, I'm wearing this today and I'm always amazed at how bold the Beth Ditto for Evans stuff was - it's all pretty unapologetic and I always feel extra visible when I wear one of the pieces I bought from it. I don't really feel like any collaboration has come close since, especially in terms of also being good quality and well tailored. Sigh.


Welcome to another installment in the 'I SPY' series. This week, we'll be taking a look at Queen City at Indianapolis Week 7 prime time matchup.
Here we see the Corsairs come out in 'split spread: 90 y quick out'. The Red Devils counter by deploying their 5 star secondary in 'nickel: 2 bump'. At the snap, there's instant pressure in quarterback AJ Caswell's lap caused by defensive tackle Bryan Dagger, as he drives center Roderick Kidd backwards. That slight pressure causes Caswell to have to move to find a new throwing window and throws off the timing of the quick slant.
Here, you get a great look at the pressure that caused Caswell to have to relocate and the ball skills of Indy corner, Von Seniuk. Seniuk does a phenomenal job of remaining in the receiver's "back pocket", which means he's trailing on purpose because he knows he has safety help over the top in case he gets beat going after the ball. This was an exemplary job by the entire defense of operating as a unit and every member doing their job.
It's not all about sacks and tackles for loss when it comes to defensive line play. They're an unheralded group that often get overlooked when they're not involved in highlight plays. But tiny things like pressures, clogging running lanes, or beating blocks that force backs into other defenders arms are the difference between good defenses and great defenses. It all starts up front.
Be on the lookout for more plays that 'I SPY' on!


text:
Current Issue First Look Ahead of Print Archive About the Journal Editorial Ethical Standards Reviewer procedure Peer review process Open Access Policy Contact List of Reviewers 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011
Editorial Ethical Standards Reviewer procedure Peer review process Open Access Policy Contact
About the Journal Editorial Ethical Standards Reviewer procedure Peer review process Open Access Policy Contact
List of Reviewers 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011
Keyword survival
Influence of nitrogen fertilization on biology of Aphis gossypii (Hemiptera: Aphididae) reared on Chrysanthemum iindicum (Asteraceae)
Mohammad Rostami, Abbas Ali Zamani, Shila Goldasteh, Reza Vafaei Shoushtari, Katayoon Kheradmand Katayoon Kheradmand
Journal of Plant Protection Research 2012;52(1):118–121
DOI: https://doi.org/10.2478/v10045-012-0019-2
Suitability of Centella asiatica (Pegaga) as a food source for rearing Spodoptera litura (F.) (Lepidoptera: Noctuidae) under laboratory conditions
Saeedeh Javar, Ahmad Said Sajap, Rozi Mohamed, Lau Wei Hong
DOI: https://doi.org/10.2478/jppr-2013-0028
The influence of long-term storage in liquid nitrogen on survival and pathogenicity of Phytophthora infestans isolates
Sylwester Sobkowiak, Hanna Zarzycka, Jadwiga Śliwka
DOI: https://doi.org/10.24/v10045-012-0077-5
Age and stage-specific life-table of cabbage butterfly, Pieris brassicae L. (Lepidoptera: pieridae) on various cole crops
Parvez Qamar Rizvi, Arshad Ali, Samreen Khalid
Survival potential of Phytophthora infestans sporangia in relation to environmental factors and late blight occurrence
Olanya Ocen Modesto, Mohd Anwar, Zhongqi He, Robert Philip Larkin, Charles Wayne Honeycutt
Journal of Plant Protection Research 2016;56(1):73–81
The effects of fungicides on Fusarium oxysporum f. sp. lycopersici associated with fusarium wilt of tomato
A short history of insecticides
Trichoderma spp. - application and prospects for use in organic farming and industry
Prospecting of pathogen-derived elicitors for the control of tomato bacterial spot
Efficacy of salicylic acid and a Bacillus bioproduct in enhancing growth of cassava and controlling root rot disease
Antifungal and plant growth promoting activity of Trichoderma spp. against Fusarium oxysporum f. sp. lycopersici colonizing tomato


text:
Socialist Equality Party (US) National Congress adopts resolution on the coronavirus pandemic and the fight for socialism
The Political Committee of the Socialist Equality Party (US)
The Socialist Equality Party in the United States held its sixth National Congress from July 19 to July 24, 2020. Due to the ongoing coronavirus pandemic, the Congress was held entirely online.
More than 30 percent of those who attended were participating in their first party Congress, which is held every two years. Leading members of all sections and sympathizing groups of the International Committee of the Fourth International (ICFI) delivered greetings to the Congress.
Over a period of five days, the Congress discussed and then adopted a resolution, "The global pandemic, the class struggle, and the tasks of the Socialist Equality Party," which is published on the World Socialist Web Site today.
The resolution provides a comprehensive analysis of the historic, economic, social and political context of the pandemic and its revolutionary implications. Defining the pandemic as a "trigger event in world history that is accelerating the already far-advanced economic, social, and political crisis of the world capitalist system," the resolution states:
The working class is confronted with a crisis for which there is no progressive solution apart from a revolutionary struggle against capitalism, leading to the conquest of state power, the establishment of democratic control by the working class over the economy, the replacement of the anarchy of the market with scientific planning, the ending of the nation-state system, and the building of a global socialist society dedicated to equality, the elimination of poverty and all forms of oppression and discrimination, a massive rise in the standard of living and the level of social culture, and the protection of the environment.
The resolution analyzes the crisis triggered by the pandemic in a broader historical, socioeconomic and political context:
While the specific conditions that produced the coronavirus have an accidental and contingent character, the response to the pandemic has been determined by the pre-existing conditions of capitalist crisis and the interests of the ruling class. The capitalist class has continued and intensified the same parasitic economic relations and social policies that it employed during the previous period.
A central theme of the document is that the pandemic marks a historic turning point whose impact will prove no less decisive in shaping the course of the twenty-first century than that of World War I on the twentieth century. Rejecting the view that the fight against the pandemic is primarily a medical problem, the resolution explains: "As the uprising of the working class was necessary to bring an end to World War I, the class conscious intervention of the working class, in a struggle against capitalism, is necessary to create the conditions for an effective social response to the disease."
The resolution examines the economic, social and political logic underlying the events of the last half-year. "To understand the present situation and chart a course for the future, it is necessary to review how the crisis has developed in the country which has become the global center of the pandemic, the United States."
The resolution identifies three distinct stages in the development of the crisis.
The first stage was between December 2019 and March 27, 2020: "The outbreak of the pandemic, the suppression of information and the rescue of the corporate-financial elite." It was during this period that the Trump administration and congressional leaders of both capitalist parties "made the socially catastrophic decisions that prioritized the rescue of the banks, large corporations and powerful Wall Street investors over preventing the spread of the pandemic and saving lives."
Rather than taking measures to stop the pandemic, the ruling class pursued a policy of "malign neglect"—an "attitude of indifference on the part of governments to the virus, [which] was conditioned by concerns over its impact on the markets." It used the months of February and March to prepare and implement a multitrillion-dollar bailout of Wall Street, culminating in the enactment of the so-called CARES Act on March 27, adopted nearly unanimously by the Democrats and Republicans.
While the ruling class sought to suppress any response to the pandemic, the resolution calls attention to the reaction of the working class:
In opposition to the ruling class's policy of "malign neglect," the working class began taking action to protect itself against the pandemic. Walkouts and protest actions were organized by workers employed by Instacart, Amazon and Whole Foods. Auto workers in the United States and Canada carried out a series of wildcat actions, which coincided with a wave of strikes and protests in Europe. Articles published on the WSWS and statements by the SEP, including the March 14 statement, "Shut down the auto industry to halt the spread of the coronavirus!," were read and shared by tens of thousands of workers. Under growing pressure from the working class and with the bailout legislation still in preparation, the federal, state and local governments were compelled to accede to a lockdown of the economy.
The second stage, between March 27 and May 31, 2020, was dominated by the reckless "back to work" campaign of the ruling class and the eruption of protests against police violence. The resolution reviews the bipartisan campaign within the political establishment to force a return to work, which began with a column advocating a policy of "herd immunity" by Thomas Friedman of the New York Times. The resolution cites the warnings from the SEP and the WSWS that this policy would lead to an explosion of new cases and deaths.
The resolution analyzes the massive multiethnic and multiracial protests over police violence that spread throughout the US and internationally in late May following the murder of George Floyd:
While the protests were sparked by police violence, their underlying causes were anger over the protracted and severe decline in living standards, the crushing debt levels imposed upon youth and the bleakness of their prospects for the future, pervasive social inequality and its consequences, the constriction of democratic rights, and the impossibility of effecting meaningful change and improvement in social conditions within the framework of the existing political structures of the two-party system.
The third stage began with Trump's June 1 press conference at the White House, at which he declared his intention to invoke the Insurrection Act to deploy the military against the protests. This initiated the administration's ongoing attempts to establish a presidential dictatorship. While this initial coup attempt was not successful, the SEP warned in a statement on June 4, cited in the resolution, that "nothing could be more dangerous than to think that the crisis has passed. It has, rather, just begun."
This warning was confirmed even as the SEP Congress was meeting, with the deployment in Portland, Oregon of federal paramilitary forces operating under Trump's command. Anticipating the threats over the past week by Trump to delay or cancel the upcoming elections, the resolution warns: "Regardless of which party wins the election—and that requires the debatable assumption that the election will be held—the tendencies that found such noxious expression during the Trump administration will persist and worsen."
The Democrats responded by ceding all opposition to Trump to the military, while escalating their own campaign to divert social opposition. "The sections of the capitalist class and the affluent middle class aligned with the Democratic Party," the resolution states, "always extremely sensitive to any sign of working class militancy and socialist influence, intervened to hijack the demonstrations and misdirect them along explicitly racialist lines."
Congress delegates participated in an extensive discussion on the background to the Democrats' racialist campaign, legitimized by the New York Times 1619 Project, to rewrite American history:
Determined to disorient the protest movement and suppress the growth of the class struggle, the New York Times intensified its campaign—which it had initiated in August 2019 with the launching of the 1619 Project—to discredit the American Revolution, the Civil War and its principal leaders. What began as a legitimate demand for the removal of the statues of leaders of the Confederacy became the occasion for defacing and removing statues that memorialize the lives of Washington, Lincoln, Grant and even a prominent abolitionist.
Notwithstanding attempts to place "race" at the center of politics, the resolution insists that "the overwhelming social reality of the United States is economic inequality, which is rooted in the division of society based on class."
The resolution also warned of the escalating preparations by the United States for war. Both Trump and the Democrats, moreover, are committed to an expansion of war abroad. The resolution states:
Throughout the pandemic, there has been no letup in the bellicose policies of the United States. US Secretary of State Michael Pompeo has maintained a heavy travel schedule, demanding support for American threats against Russia and its primary geo-political rival, China. The Trump administration has sought to generate hostility by referring regularly to the "Wuhan virus," even to the point of claiming, without any evidence, that China set out to infect the American public.
The resolution warns:
The danger of war should not be underestimated. There are many examples in the twentieth century of a crisis-ridden regime—that of Hitler is the most notorious example—resorting to war as a solution to what it perceives to be a desperate crisis within the border of its own country.
On the basis of its analysis of the past seven months, the resolution advances a perspective and program of action for the weeks and months ahead:
The first half of the year has been dominated by the response of the ruling class to the pandemic. The response of the working class will come to the forefront in the second half. The disastrous consequences of the ruling class's policies have delivered a staggering blow to the legitimacy of the capitalist system. The corporate response to economic collapse—mass layoffs, wage-cutting, demands for the further slashing of expenditures for Medicare, Medicaid, Social Security and other vital and already underfunded social programs—will meet with growing resistance in the working class. Opposition will mount to working in unsafe conditions and to school reopenings that facilitate the spread of the COVID-19 virus. There will be opposition to evictions and foreclosures. Therefore, the Socialist Equality Party foresees an immense growth of working class struggle, which through the intervention of the party will assume a politically class conscious and anti-capitalist character.
In outlining the tasks of the Socialist Equality Party, the resolution explains the significance of "transitional demands" that
connect the issues and needs arising from a concrete situation to the strategy of socialist revolution. In relation to the coronavirus pandemic, the SEP calls for and will fight for an end to the reckless and criminal back-to-work campaign; the repeal of the corporate-Wall Street bailout; an emergency program to provide economic security for all unemployed people and vastly expand the health care infrastructure; the expropriation of the wealth of the corporate and financial elite to address the urgent social crisis facing tens of millions of people; and the establishment of workers' democratic control of the major banks and corporations.
In the discussion of the resolution, Congress delegates emphasized the relationship between the development of the objective situation and the activity of the Socialist Equality Party. There was extensive discussion of the SEP's experience in establishing rank-and-file safety committees in factories and workplaces to protect workers against the threat posed by viral transmission.
Changes and additions proposed by delegates in the course of the discussion were incorporated into the final draft of the resolution. The vote on the resolution was conducted online, and it was passed unanimously.
The Congress delegates elected a new national committee. The members of the incoming national committee reelected Joseph Kishore as national secretary, Lawrence Porter as assistant national secretary, and Barry Grey as US editor of the World Socialist Web Site. The Congress delegates reelected David North as national chairman.
The Congress resolution provides an unequaled analysis of the crisis triggered by the pandemic, directed toward the development of socialist class consciousness and the independent action of the working class. It provides a direction for revolutionary politics and the development of a socialist movement of the working class. It deserves the most careful study by workers and young people in the United States and throughout the world.
Read the resolution, "The global pandemic, the class struggle, and the tasks of the Socialist Equality Party." To contact and join the SEP and the ICFI, click here.
Stop Trump's coup d'état! Mobilize the working class against authoritarianism and dictatorship!
PerspectivesThe Crisis of American DemocracyUS PoliticsUnited StatesNorth AmericaWorld NewsStatementsTrump and the danger of fascism in America


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We deeply mourn the sudden passing of Jnan-da. He was admitted to the hospital this morning, but could not survive cardiac arrest. Dr. Jnanendra Bhattacharjee was Professor Emeritus of Microbiology at Miami University, in Oxford, Ohio and widely recognized as an eminent scholar and dedicated teacher. He was a strong leader of Cincinnati's Bengali community, and has always represented it with pride and dignity.
Jnan-da, as he was known to many, was always enthusiastic about children's cultural performances, and encouraged adults to leave the stage for children, when stage time was challenging to find at TSDP. He was an ardent supporter of numerous social causes and consistently generous toward many, in the Bengali community as well as at Miami and in the Oxford community.
Jnan-da is survived by his wife Tripti-di, and his children, Gourav and Mala, and scores of admirers in the tri-state communities.Our celebrations this year were bracketed by the sad demises of two of our stalwarts, on either side of our Durga Pujos.
As we offer our prayers for the departed souls, may we humbly request all members of Cincinnati Cultural Initiative to refrain from Liking or Commenting on Pujo-related photographs on the CCI Facebook page for one day, on Tuesday, Oct-7th, as a mark of respect.
Thanking you, for your kind consideration.
What a start to Day 1 of Cincinnati Durga Puja !
What an amazing kick off to the annual Cincinnati Durga Puja this evening... the raw pictures hot off the press are here. More to come over the next few days .. meanwhile, feel free to tag yourself and your friends !!
The Puja was streamed live at our website www.cdu2014.org. Let your friends and family know that they can watch the festivities and more importantly, they can watch your participation from across the globe through our live streaming!!
Looking forward to tomorrow and day after, meeting new people, making new friends, re-kindling old acquaintances.
For our out of town and out of state participants to the annual Cincinnati Durga Puja, who are looking for area hotels, here is a list compiled for your convenience. All hotels are within a 15-20 minute driving distance from the venue.
We have no negotiated rates with any of the hotels, and we do not endorse any particular hotel. So feel free to choose any as per your convenience.
As we make a bee-line for the annual Cincinnati Durgotsav this weekend, please remember to contribute to the Food Collection Drive... non-perishable food items such as below (no glass please) will be collected at the puja venue in support of Matthew 25: Ministries and their work with the poorest of the poor and disaster victims. Thank you for your support.
Holiday foods like cranberry sauce, dry stuffing mix, cake mixes & frosting, etc.
Instant mixes like potatoes, gravies and sauces .
Canned meats (tuna, chicken, salmon) that do not require refrigeration before opening.
Its finally here! Our Cincinnati Durga Puja 2014 celebrations start tomorrow evening. Please check out the Puja Schedule as you plan out your mornings, afternoons, evenings (and the dress-change breaks in between) over the next 3 days.
Today is also the last day for registrations before the rates go up tomorrow. Thanks to all those participants who have registered by now through our easy-to-use online payment features. If you have not done that yet, you can still do it here.


These tables show the national contributions to the outstanding amounts, gross issues and net issues of debt securities other than shares issued by euro area residents, broken down by sector of the issuer and by maturity.
The data up to the end of November 2012 are computed in accordance with the ESA 95 methodology. Thereafter, the data are based on the ESA 2010 methodology. The data up to the end of November 2012 are computed in accordance with the ESA 95 methodology. Thereafter, the data are based on the ESA 2010 methodology.
The data concerning the general government sector are not directly comparable with the data on government debt collected for the purposes of the "excessive deficit procedure" of the Stability and Growth Pact described in Council Regulation (EC) No 1467/97 of 7 July 1997.


text:
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Journal of Psychiatry Depression & Anxiety	Category: Clinical Type: Case Report
Dose Positive CHD8 have a Role in Ketogenic Diet Response in Autism: A Case Report
Amal AlQassmi1*, Maha AlOtiabi2 and Fahad AlRabeeah3
1 Department Of Pediatric Neurology And Epilepsy, King Saud Medical City, Riyadh, Saudi Arabia
2 Department Of Psychiatry, King Saud Medical City, Riyadh, Saudi Arabia
3 Pediatric Endocrinology, King Saud Medical City, Riyadh, Saudi Arabia
*Corresponding Author(s):
Amal AlQassmi
Department Of Pediatric Neurology And Epilepsy, King Saud Medical City, Riyadh, Saudi Arabia
Tel:+966 570006241,
Email:dr_alqasmi@yahoo.com
Received Date: Dec 04, 2017
Accepted Date: Jan 29, 2018
Published Date: Feb 12, 2018
DOI:10.24966/PDA-0150/100012
Autism is a brain disorder that limits a person's ability to communicate and relate to other people. The symptoms of autism spectrum disorder are poorly treated with current medications. Symptoms of autism spectrum disorder are frequently co-morbid with a diagnosis of epilepsy. Ketogenic diets are remarkably effective in treatments for epilepsy in children in the same time there are several studies showed the effectiveness of ketogenic in Autism and behavior associated with it.
This study tests the effects of ketogenic diet feeding in Autism and their behavior, a child with autism spectrum disorder. The child was started on ketogenic diet formulas starting at 5 years of age, diet protocols continued and performance of tests of sociability and repetitive behavior was assessed. A ketogenic diet improved behavioral characteristics of autism spectrum disorder. Ketogenic diet feeding improved multiple measures of sociability and reduced repetitive behavior in autism child. Positive gene mutation of autism may be an important factors in showing the response of high lipid diet in those children.
Autism; Behavior; Gene; Lipid diet; Sociability
Autism is a brain disorder that limits a person's ability to communicate and relate to other people. It first appears in young children, who fall along a spectrum from mild to severe. Some people can navigate their world, some have exceptional abilities, while others struggle to speak [1,2]. Autism Spectrum Disorders (ASDs) affect about one child in 68, striking nearly five times as many boys as girls.
Before a child turns three, careful observers can see signs of autism [1]. Some children develop normally until 18-24 months old and then stop or lose skills. Signs of an ASD can include: Repeated motions (rocking or spinning), avoiding eye contact or physical touch, delays in learning to talk, repeating words or phrases (echolalia), getting upset by minor changes. It's important to note that these signs can occur in children without ASDs, too [3].
The signs of autism are more noticeable in a child's second year. While other children are forming their first words and pointing to things they want, a child with autism remains detached. Signs of autism include: No single words by 16 months, no pretend games by 18 months, no two-word phrases by age 2, loss of language skills, no interest when adults point out objects, such as a plane flying overhead.
ASD has been associated to metabolic dysfunction [4,5] and autism is a common trait of epilepsy-associated diseases [6], and syndromes like Landau-Kleffner, Dravet [7], and Rett [8]. Thus, given the beneficial effects of KGD on epilepsy and increased mitochondrial function, its use has the potential to ameliorate some of the ASD-associated symptoms.
How we diagnosed Autism, by early assessment and evaluation by phycology and neurology [9]. There no specific management for autism, although there is now a trial of stem cell therapy that show some improvement in reported cases, but dose natural diet is more effective and is that related genetic type that had been describe in many cases of autism [4].
The use of the ketogenic diet to treat epilepsy dates as far back as Hippocrates time. The major way to induce ketosis at that time was using fasting or starvation. Since then, modern reports put the use of the KD in treating childhood epilepsy starting in the 1920's [10].
It was within this time that discoveries were made to show that the same level of ketosis could be induced with carbohydrate restriction and higher levels of fat intake.
Although the KD is an established treatment option in the major epilepsy centres around the world, the exact mechanism of its action is still not fully understood.
Over the past 2 decades, the understanding into the mechanism has begun to grow. Proposed mechanisms of action for the anticonvulsant effects of the ketogenic diet are believed to be due to:
The state of ketosis, a reduction in glucose levels, a rise in fatty acids and enhanced bioenergetic reserves.
It is believed that the ketone bodies produced with the ketogenic diet provide the anticonvulsant effects as well as reducing neuronal excitability in the brain [11]. However, the exact link between ketone bodies and the anticonvulsant efficacy of the ketogenic diet is not fully understood.
The mechanism by which KD acts is not clearly understood. However, among the many hypotheses advanced, elevation of brain acetone may account for the efficacy of the diet in epilepsy as it has proven anticonvulsant effects [12].
Ketogenic diet had been tried in treating Autism, but no clear hypothesis or mechanism of the Diet in Autistic spectrum. The suggested mechanisms of action of KD in ASD include that it may reduce pain sensitivity through the reduction of glucose and may have anti-inflammatory properties as it reduces swelling and plasma extravasation [13].
We present a case of 7 and 6 months old Saudi boy who presented to neurology with history of speech delayed and behavior issue that had been concern by parents since age of 2 years they did seek medical advice, but no clear or major help was provided by general physician till age of 4 years where he had been referred to neurology for assessment.
This child was born healthy with no risk of asphyxia or neonatal intensive care admission, normal motor developmental apart from social skills and behavior problem, delayed speech till age 4 years, still not able to form a sentence or connect 2 words together unable to express himself, no eye to eye contact, scream a lot, had difficulty to engaged with other kids, walking in circle, enjoy cars, he keep a small fork that he attached to since age of 2 years and 8 months.
After we did full history and examination which was normal apart from social developmental, speech delayed. Blood work up (CBC and chemistry) was normal, bone profile and renal function was normal. Metabolic screening (serum amino acid, urine organic acid, quantitative amino acid, CDT) all was normal. MRI (Magnatic Resonance Imaging) brain normal, EEG (Electro Encephalogram) was normal, BEAR (Hearing Test) was done normal, patient seen by psychiatry and the Autism Rating Scale score assessment was diagnosed as autism scored 49, IQ assessment was 85%, SNP array was not significant, patient was diagnosed with Autism.
As there was a few reports diagnosed gene mutation in Autism, we did send whole exome to see any positive gene will be found and would that be useful for parents if they will consider to have another baby, the result came positive for CHD8:NM_001170629:exon26:c.4984C>T:p.R1662X heterozygous (autosomal dominant). Family segregation done was negative for both parents.
This patient was started on Risperdal but no much improvement in his behavior. Then shifted to Methylphenidate no much change, parents decide to stop it by their own.
Parents tried to keep him in special diet (their own effort) as they read about avoiding carbohydrate in Autism, so they kept him on regular food with less amount of carbohydrate and milk content, and they notice change in his behavior and his sleep pattern change. So, that raise the point of ketogenic diet if that similar to what they are doing or different.
There is no enough data about the use of ketogenic diet in Autism but was worth to try and see if that will support the previous report had been published.
Following this detailed investigation, the parent's consent was obtained to have the children placed on a ketogenic diet. The recommended diet was Consists of 71-7% energy from fat, of which 30-40% energy is from MCT and 11-25% energy is from LCT 20% as fresh cream. This version of the KD provides more protein (10% energy) and carbohydrates (15-19% energy).
Patients also received vitamin and mineral supplements according to the recommended daily allowances for age. In this diet, 30% of total energy is derived from medium-chain triglycerides. The classic ketogenic diet is very restrictive and requires a large amount of dietetic involvement in terms of calculations, monitoring, patient support, and motivation from the family to adhere to the diet; consequently it is difficult to adapt the diet for children with mental retardation.
Patient started on ketogenic diet 1.5:1 then 2:1 lipid : non lipid food. Diet was continue for 6 months with a period of break for 6 weeks.
Over the course of 18 months following his initial diagnosis, during that period diet introductions, he was seen and follow by psychiatry, the child's Childhood Autism Rating Scale score decreased from 49 to 17, representing a change from severe autism to non-autistic, and her intelligence quotient increased 60 points.
The result was so impressive and parents did notice the difference in their child behavior response, his ability to understand and communicate is improved and his repetitive behavior (walking in circle and repeat words) improved and school performance, he is in grade 1 school, doing great. He was still in Ketogenic diet with a period of rest for 2-3 months in between then back to same keto-diet again. No side effect was reported in our patient during his treatment over 2 years period now. Interestingly that we stopped keto-diet as is not easy to follow even with close monitoring from parents which was a huge effort from them, but parents continue on sugar free and dairy product free with a break of 1 week, which really shows a good result and progress in his developmental and communications skills.
Autism Spectrum Disorders (ASD) include a complex neuro developmental condition characterized by abnormal social interaction, verbal and non-verbal communication [1]. Limited scientific advances have been made regarding the causes of ASD, with general agreement that both genetic and environmental factors contribute to this disorder [14]. ASD has been associated to metabolic dysfunction [5].
Changes in over 1,000 genes have been reported to be associated with ASD, but a large number of these associations have not been confirmed. Many common gene variations, most of which have not been identified, are thought to affect the risk of developing ASD, but not all people with the gene variation will be affected. Most of the gene variations have only a small effect, and variations in many genes can combine with environmental risk factors, such as parental age, birth complications, and others that have not been identified, to determine an individual's risk of developing this complex condition. Non-genetic factors may contribute up to about 40 percent of ASD risk.
By contrast, in about 2 to 4 percent of people with ASD, rare gene mutations or chromosome abnormalities are thought to be the cause of the condition, often as a feature of syndromes that also involve additional signs and symptoms affecting various parts of the body. For example, mutations in the ADNP gene cause a disorder called ADNP syndrome. In addition to ASD and intellectual disability, this condition involves distinctive facial features and a wide variety of other signs and symptoms. Some of the other genes in which rare mutations are associated with ASD, often with other signs and symptoms, are ARID1B [15], CHD2, CHD8 [16], DYRK1A, SHANK3 and SYNGAP1. In most individuals with ASD caused by rare gene mutations, the mutations occur in only a single gene.
In our patient, it had CHD8 gene mutation, in spite different gene mutations had been discovered in Autism but none of them had different presentation or describe the severity of behavior changes in Autistic child and non-had addressed the use of ketogenic diet in this different type of mutations.
Beneficial effects of KGD in children with ASD symptoms have been reported in two independent studies [17,18]. The first study evaluated the role of KGD on 30 ASD children [17]. The John Radcliffe diet (a modified medium-chain triglyceride diet with a caloric distribution of 30% in medium-chain triglyceride oil, 30% fresh cream, 11% saturated fat, 19% carbohydrates, and 10% proteins) was administered for 6 months, with intervals of 4 weeks interrupted by two diet-free weeks. Of the 30 children, 40% did not comply or did not tolerate the diet. From the rest, the two children with the milder autistic behaviors showed the most improvement (as judged by total Childhood Autism Rating Scale score, concentration and learning abilities, and social behavior and interactions), while the rest displayed mild to moderate improvements. Interestingly, the beneficial effects of KGD persisted even after termination of the trial. Six of the children enrolled in this study had a higher baseline ketonemia with no apparent PDH and/or RC deficiencies; but it is not clear if any of the other patients underwent this screening, before and/or after the administration of the diet in addition to the lack of the inclusion of a control diet before administering the KGD to the ASD group or during the trial.
The other study [18] reports the administration of a gluten-free casein-free modified KGD (1.5:1 lipid : non-lipid ratio; medium-chain and polyunsaturated FA) for 14-months to a 12-year-old child with ASD and seizures with substantial medical comorbidities associated with a family history of metabolic and immune disturbances. Due to the improvements in seizure activity, improved electroencephalogram, cognitive and social skills, language function, and complete resolution of stereotypies, anticonvulsant medication doses were reduced without worsening of seizures. Of note, the administration of the diet was accompanied by a wealth of medications, a significant weight loss, and transitioning to puberty, so it is difficult to assess the sole role of the diet with this clinical background.
A ketogenic diet would extremely limit the sweet and starchy processed foods. This deprives certain gut bacteria of the food they need and may be a way to help restore balance in the microbiome. To further the argument of the role that the gut microbiota play on autism [19].
In mouse models of ASD Rett syndrome [20], and Succinate Semialdehyde Dehydrogenase (SSADH) deficiency [21], the use of the KGD has improved behavioral abnormalities (increased sociability and decreased self-directed repetitive behavior) and/or decreased the number of seizures, normalized ataxia, and increased lifespan of mutant mice. However, while the KGD was originally designed to be administered under controlled caloric intake. Most of the mouse studies have been performed under ad libitum conditions and/or for a relatively short period [18]. Moreover, a ketogenic low-carbohydrate diet does not have a significant metabolic advantage over a non-ketogenic low-carbohydrate diet as judged by equal effects in body weight reduction and decreased insulin resistance; however, the former one was associated with higher inflammatory risk and increased perception of fatigue.
In a case study of a child with autism and epilepsy, following standard treatment non-response, the individual was placed on KD (1.5:1 lipid: non-lipid ratio) with adjunct anticonvulsant therapy [22]. The patient was in ketosis. After initiation of the diet several benefits ensued including the resolution of morbid obesity and the improvement of cognitive and behavioural features of the disorder. After several years on the diet, the patient's score on the Childhood Autism Rating Scale decreased from 49 to 17, a change from a rating of severe autism to non-autistic, and IQ increased by 70 points. Fourteen months following the initiation of the diet the patient was also seizure free.
Although the exact molecular mechanisms underlying the effect of the KGD are still under investigation, several scenarios are reported below to explore the potential therapeutic effects of the KGD in ASD.
Would the effect of ketogenic diet related to the different gene mutation that is associated with Autism not clear, this need more study and research.
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Mantis JG, Fritz CL, Marsh J, Heinrichs SC, Seyfried TN (2009) Improvement in motor and exploratory behavior in Rett syndrome mice with restricted ketogenic and standard diets. Epilepsy Behav 15: 133-141.
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Citation: AlQassmi A, AlOtiabi M, AlRabeeah F (2018) Dose Positive CHD8 have a Role in Ketogenic Diet Response in Autism: A Case Report. J Psychiatry Depress Anxiety 4: 012.
Copyright: © 2018 Amal AlQassmi, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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At last, the Simplicity tank is finished! You can see the finished photo on the sidebar or read a little more about here on Pattern Review. So what do I think about this pattern?
First off, I can tell that this tank is really designed for a fuller bust. I feel like the cups are much too large for my girls (who are not the b-cup that most pattern companies draft for). If I make this again, I will definitely make an adjustment in this area. Other than that, the fit is really nice – for once I didn't have the gaping under the arms and the back fits snugly – so I'm not having to tugging at it to pull it up. My only suggestion is that you wait to hem your garment until it's completely finished and let it hang for a day or to avoid having to adjust your hem for fabric stretch.
Now, onto this week's goal: Construct eye pillows for the Craftster Sweat Shoppe Shop and start on a second project. At the moment, I'm extremely torn between the Onion Jacket and Jalie top!
This entry was posted in Simplicity 3956 Layered Tanks on March 11, 2007 by stacy.
I finished all of my owls yesterday. Yahoo!
Wow, you're fast! I'm putting an owl on my SSS8 wishlist!
The tank looks great on you. I do love those fabrics, too.
You top turned out really cute. I almost bought that pattern (thank goodness I didn't because I have too many patterns, more on that later), but I dislike the skinny straps for me. It looks great on you.
I vote for the jacket, then the top, because with the weather getting warmer you won't have too long before it's too warm to wear it.
This top turned out really gorgeous! You look stunning in it!
I LOVE it! it looks great Stacy! I like the print combo too 😀 good job!


There's a new number one leading the NBC Top 10 Senate takeovers list.
That dubious honor belongs to North Dakota, where Democratic Sen. Heidi Heitkamp finds herself in a tough race against Republican Rep. Kevin Cramer.
An important note: These rankings are based on the likelihood of the seat flipping parties. And it's based on where we see these races RIGHT NOW, not what we think will happen a month from now. Indeed, the fight over Supreme Court nominee Brett Kavanaugh could be over this week, or there could be new damaging information that hurts GOP candidates backing his nomination.
One way to look at the rankings: Nos. 1-3 are leans to switching parties; 4-5 are true toss-ups; and 6-10 are slight leans to the incumbent.


text:
About PACAC
PROFESSOR BOLAJI OWASANOYE
Member / Executive Secretary, Presidential Advisory Committee Against Corruption
Professor Bolaji Owasanoye is renowned for his expertise in International Economic Law;Human Development and Social Justice Activism. He has been a Professor of Law for about 15 years with the apex legal academic institution in Nigeria: The Nigerian Institute of Advanced Legal Studies (NIALS) where he served as two-time Director of Research, and the rst to be conferred with the Taslim Elias Distinguished Professor of Law. He has pro ciency in teaching Legal Aspects of External Debt Management, Corporate Law, Legislative Drafting, Human Rights and Strategic Governance amongst others. He has provided academic service to several tertiary institutions including the Lagos State University 1986 1990;Nigerian Institutte of Advanced Legal Studies (1991 2015; Professorial Research Associate, University of London School of Oriental and African Studies 2011 to 2013; University of Pretoria (Visiting Professor, 2015. As a consultant with over 30 years of experience in law development, Prof Owasanoye has consulted for federal and state agencies in Nigeria and international agencies such as UNITAR, UNICEF, USAID, DFiD, World Bank, World Bank Institute, ILO, Ford Foundation and ECOWAS. PROFESSOR BOLAJI OWASANOYE Member / Executive Secretary, Presidential Advisory Committee Against Corruption He was part of the reconstituted 9-member Law Revision Committee that produced the 2004 Laws of the Federation of Nigeria, a compilation of the 724 federal laws of the country. He was African Representative on Data Task Force of Child Helpline International 2004-206; African Regional Representatives on Criminal Law Committee of the International Bar Association 2011-2013; Chairman, ECOWAS Drafting Committee on Community Investment Code 2011 – 2014; Member African Union Group of Experts on Pan African Investment Code 2013-2015; Member IBA Presidential Task Force on Human Traf cking 2015; He co-founded one of Nigeria's leading social justice NGOs: the Human Development Initiative (HDI). Set up in 1997, HDI has successfully implemented over 50 advocacy projects on human rights, rule of law, governance and anti-corruption, one of which is the celebrated 'Stop Impunity Nigeria Campaign' focused on eliminating impunity in public nance management and promoting civic responsibility. Hehas won severalawards, few of which are: the University of Lagos Scholarship Award (1986 – 1987); UN Institute for Training and Research Fellowship Award (1991 and 1994 respectively); U.S. Information Service International Visitors Award (1991); British Council Fellowship Award (1992); International Youth Foundation (IYF-US) Fellowship on Youth and Community Development (1999-2000) and Senior Special Fellowship, United Nations Institute for Training and Research, (2001). He holds Qualifying Certi cates in Legal Aspects of Public Debt and Financial Management; Legislative Drafting and Managing Development; Certi cate in Negotiating International Trade Agreements and a Certi cate in Managing Development Projects. He has published over 100 academic and research projectsin national and international journals and has authored/edited over 10 books. He mentors young lawyers and academics in Nigeria and serves as member of the Clergy at Chapel of Christ Our Light University of Lagos and the State House Chapel at the Presidential Villa in Abuja. He is happily married with children.
President Muhammadu Buhari, GCFR, as part of government's anti- corruption ght, constituted the Presidential Advisory Committee Against Corruption (PACAC) in August 2015. It was the very rst committee he set up after he was sworn into of ce on May 29th 2015.
PACAC commenced work on August 10, 2015 with the mandate to, inter alia - promote the reform agenda of the government on the anti-corruption effort, to advise the present administration in the prosecution of the war against corruption and the implementation of required reforms in Nigeria's criminal justice system. A 7- member Technical Committee supports the PACAC.
State House, Aso Villa, FCT
© 2017 - Presidential Advisory Committee Against Corruption


text:
Q: How to share print drivers from a 64 bit Windows server to 32 bit client machines I'm sure this is a dumb question, but I can't for the life of me figure out what the heck is going on. I've looked around and I've seen similar questions of this nature, but nothing exactly matching my issue.
I'm looking to replace my current file/print server. In place of the old one would be a 64 bit Windows Server 2008 R2 Standard SP1. I have added the 64 bit drivers to the server, but it's my understanding that I need to push 32 bit drivers to my clients (as they're all 32 bit machines).
So I go into the Printer Properties and select the Sharing tab. I click the "Additional Drivers" button and attempt to select x86. I then point to the 32 bit drivers for the printer in question and hit okay. Then I'm asked to provide a path to the I386 folder (which I do) but every time I click "OK"it keeps asking for that folder again. I end up in an endless loop of trying to show the system where the folder is.
Can someone provide me with some guidance about what I'm doing wrong? Any guidance is appreciated.

A: I had a similar question. x64 print driver keeps asking for x64 windows disk
Do what I did but from a 32-bit system.
It looks like the best way to make this work and not ask for the i386 folder is to set the printer through a x32 bit OS.

*

*Start > Run > \\servername

*Right click on the printer you want to add the x32 bit driver to and go to Properties

*Sharing tab > Additional Drivers button

*Check the box for x32 > Ok > Point to the location of your x32 bit drivers


I am writing a plugin that allows the user to insert an address.
When the user selects an address it should be inserted at the current cursor position.
The address is an array of strings. Each string should be placed on a new line.
When trying the oParagraph.addText() approach from the helloworld example the text is always inserted flush left.
The symboltable example seems to consider the cursor position but uses an un-documented function called "PasteHtml".
Please use oParagraph.addText() but it's not necessary to add whole text via one command.
Yes, it's not documented yet. We will but you can use it - insert content in html format "PasteHtml".
Insert text at cursor position is possible via API with drag & drop event?
unfortunately, text insertion via drag&drop is not supported.


Even if the rain does not go away as in the song; this cutie will always find a way to..
They say this week it will rain cats and dogs, but you shouldn't care! You can remain stylish while walking through the muddy roads. These colourful raincoats are perfect with jeans or skirts and rubber rain boots. Don't forget to choose a fancy umbrella to look dry and chic!
What is the best part going for a walk? For most people it is the sightseeing. However..


text:
Le transport ferroviaire en Haïti se développa au cours de la seconde moitié du  et jusqu'au lendemain de la Seconde Guerre mondiale.

Ce type de transport se déclina en réseau urbain de type tramway et en réseau régional de type train.

Faute de volonté politique, de l'hostilité des américains pour ce mode de transport, notamment après leur annexion du pays en 1915 et aussi par manque de moyens financiers, le réseau de tramway s'arrêta de fonctionner avant la Seconde Guerre mondiale et le réseau ferré cessa de fonctionner vers 1960.

Histoire

Tramway
Le tramway fut mis en circulation dans les rues de Port-au-Prince en 1878. Ce premier réseau de type hippomobile circula jusqu'en 1888. Après un arrêt d'une dizaine d'années, il reprit du service sous la pression d'un groupe d'intellectuels appelé gadamh (gade moun ayiti) Présidé par le richissime amateur, normalien Jacmelien , Claude Raymond Excéus ,de 1897 à 1932 avec des locomotives à vapeur. Il fut un moyen de déplacement pour la population haïtienne.
Il y avait trois lignes:
 Ligne A : Portail Saint-Joseph au Champ-de-Mars
 Ligne B : Portail Saint-Joseph au Cimetière
 Ligne C : Champ-de-Mars à la Grand'Rue

En 1932, l'émergence du transport routier (mise en place de lignes de bus et du développement des taxis collectifs : les tap-tap), ainsi que le manque d'entretien et de financement furent fatals pour le tramway. Il fut donc supprimé dans la capitale. Le matériel roulant fut revendu aux exploitants agricoles situés dans les zones rurales, où il fut utilisé jusqu'en 1970.

Chemin de fer

La première ligne ferroviaire de l'île d'Hispaniola (comprenant également la République dominicaine) fut construite en 1868. Dans ces premières liaisons, les animaux furent utilisés pour tracter les wagons. À partir de 1897, les locomotives ont été utilisées.

En 1910, le président haïtien, François Antoine Simon, envisagea la construction de deux voies ferrées : l'une devant relier le Cap-Haïtien à Port-au-Prince et l'autre qui partirait de la capitale en direction des Cayes via Léogâne. Le président comptait sur le développement de l'exploitation de la banane qui nécessitait la construction d'un système de transport capable d'assurer son acheminement vers les ports d'embarquement, pour financer la construction de ces voies ferrées. Afin de trouver les capitaux nécessaires, le gouvernement haïtien lança donc un emprunt sur la place de Paris pour un montant de 65 millions de francs, et entama même des pourparlers avec un consortium franco-allemand, auxquels s'associèrent des banques américaines. Les conditions abusives de cet emprunt soulevèrent la méfiance de l'opinion publique haïtienne qui lui resta résolument réfractaire et qui multiplia les protestations. Le docteur Rosalvo Bobo publiait au Cap-Haïtien une plaquette qui mettait l'opinion en garde contre les graves complications diplomatiques et financières au-devant desquelles se plaçait imprudemment le gouvernement d'Antoine Simon. Bobo expose sa crainte de voir les Américains prendre le contrat de l'une des lignes projetées comme un prétexte pour envahir le pays.

Il y avait trois lignes de chemin de fer à écartement de 1067 mm. On peut citer :
 la Ligne Gonaïves - Ennery
 la Ligne Cap-Haïtien - Grande-Rivière-du-Nord - Bahon (Haïti)
 la Ligne Port-au-Prince - Saint-Marc - Verrettes.
Deux d'entre elles ont été fermées en 1960.

Il y avait aussi une ligne privée, la Compagnie des chemins de fer du Nord, dite « ligne McDonald », qui utilisait un écartement de 762 mm. Cette ligne avait une longueur de 121 kilomètres et fonctionna jusqu'en 1970.
Une deuxième société, la Compagnie des Chemins de Fer de la Plaine du Cul-de-Sac (CCFPCS), exploitait deux lignes rurales sur le même écartement de 762 mm :
 Port-au-Prince - Léogâne : )
 Port-au-Prince - Manneville (commune de Thomazeau) :

En 1972, durant la dictature Duvalier, son ministre des travaux publics, Luckner Cambronne déclara aux députés qui l'avaient interpellé que le pays n'avait pas besoin de chemin de fer et entreprit le démontage systématique de la voie entre Port-au-Prince et Saint-Marc.

Il n'y a jamais eu de liaison ferroviaire entre Haïti et la République dominicaine.

Projets
La République dominicaine qui projette de reconstituer son réseau national, propose d'y associer Haïti. Ainsi, les autorités dominicaines envisagent la construction d'un réseau transnational desservant des villes haïtiennes, une ligne entre les deux capitales, Port-au-Prince et Saint-Domingue.

Notes et références

Articles connexes
 Transport en Haïti
 Transport ferroviaire en République dominicaine

redpajama_set_name: RedPajamaWikipedia


The body of a 28 year old woman who went missing on 29 December 2018 was found buried in a shallow grave, on a farm at neighbouring Badplaas, near Carolina.
The victim, Zanele Zwane, from Nhlazatshe was last seen after she reported to her family that she was going to visit her estranged boyfriend at Badplaas and was never seen nor heard from again. When asking the boyfriend, he denied that she ever arrived at his place of residence.
The family then filed a missing person's report and a police probe revealed that the boyfriend, aged 28, allegedly committed suicide soon thereafter.
The probe pointed towards the boyfriend's friend, whom it suggested may have had a hand in her murder. The suspect eventually pointed out the shallow grave where the body was indeed found, hence his arrest on Friday 1 February 2019.
The suspect will appear at the Carolina Magistrate's Court on Monday 4 February 2019, facing a charge of murder and defeating the ends of justice.
The Provincial Commissioner of the police in Mpumalanga praised the investigating team for their commitment and valour in ensuring a breakthrough in this case. He encouraged them to ensure that the matter ends in a conviction so that it would serve as a deterrent to others.


Email newsletter service helps in informing the people about products which will lead to increase the sales. Fopik services include setup , designing of subscribes form, user list maintenance, Delivery and delivery report. Fopik also provides auto reminder system for websites.


Summit Sport Physiotherapy and Lifemark Health are proud to provide your organization, athletes and Coaches with an elite level of sport medicine support.
Athletes who develop stronger, smarter and more flexible muscles perform better. We give your players the tools they need to be better performers. When injuries do occur, we provide a comprehensive assessment, detailed treatment planning and a clear return to sport plan.
Athletes who understand their bodies, and how to care for them are more durable. Durable athletes gain more from teaching/ training and enjoy the game!


text:
12/06/16 Activists shut down panel about transparency in law enforcement Police Brutality Minneapolis, MN
3/28/16 Activists lock down Janesville, WI hotel to shut down Trump speaking event People's Struggles Milwaukee, WI
12/04/16 A Victory at Standing Rock Indigenous Peoples Canon Ball, ND
4/23/16 A left perspective: Saying goodbye to Prince Remembrances Minneapolis, MN
9/20/16 A Blatant Act of US Aggression Against Syria and Syrian People Syria Syria
2/06/16 5000 march to oppose layoffs in Chicago Public Schools Teachers Unions Chicago, IL
7/08/16 5000 march for justice for Philando Castile in Saint Paul Police Brutality Saint Paul, MN
7/12/16 500 march against racist police crimes in Jacksonville, defy police orders Police Brutality Jacksonville, FL
5/03/16 5% of Boeing stock holders vote for resolution challenging arms sales to Israel Antiwar Movement Chicago, IL
9/02/16 46th Chicano Moratorium demands end to racist police attacks Police Brutality Los Angeles, CA
11/12/16 3000 march in Salt Lake City to protest Trump Donald Trump Salt Lake City, UT
6/03/16 3 Somali American youth entrapped by FBI found guilty by all-white jury In-Justice System Minneapolis, MN
7/22/16 3 Days in rural Mindanao: Human rights abuse and land grabs Philippines Guinoman, Zamboanga Sibugay, Philippines
6/18/16 25th anniversary of AFSCME 3800 celebrated AFSCME Minneapolis, MN
12/31/16 2016: Music inspired by the struggle Music United States
2/19/16 15,000 rally for immigrant rights at Wisconsin State Capitol Immigrant Rights Madison, WI
12/07/16 1000-plus Texas A&M students protest white supremacist Richard Spencer Anti-racism College Station, TX
5/03/16 100 rally for May Day on steps of Salt Lake City and County Building Labor Salt Lake City, Utah
4/05/16 1 arrest as hundreds of anti-Trump protesters face off with Milwaukee police Anti-racism Milwaukee, WI
10/26/16 #RapeCulture is real. Trump and a key moment of national discussion Women's Movement Minneapolis, MN


For use with 1/4" (.160" I.D.) tube only. Connects 1/4" tubing to faucet or other 3/4" male hose thread. Includes filter washer.
Double barbed design allows water pressure up to 50 PSI.
Connects 1/4" tubing to existing 1/2" MPT underground sprinkler riser. Inlet: 1/2" FPT. Outlet: 1/4" compression and 1/2" MPT. Includes filter washer.
Double barbed design allows use with higher water pressures. For use with 1/4" (.160 - .197" I.D.) tube only. Creates a 1/4" branch from a 1/4" tube, or two 1/4" branches from a 1/2" hose. For water pressures up to 50 PSI.
Connects Raindrip low-flow sprinklers to 1/2" MPT sprinkler risers. Inlet: 1/2" FPT. Outlet: 10-32 FNFT. Includes filter washer.
Black poly clamps molded to fit 1/4" tubing. Includes pre-inserted nail.
Used to shut off the end of 1/2" Rain Drip poly hose. Removes easily.
Heavy-duty plastic stakes hold 1/4" lines in place.
Adjust, balances or shuts off water flow to watering circuits, zones or plants. For use with 1/4" (.160" I.D.) vinyl tubing only. Double barbed design allows water pressure up to 50 PSI.
Pre-assembled adjustable sprinkler head with 13" stake and 8" adjustable riser. Turn the knob to adjust the flow (4 to 20 GPH at 25 PSI) and spray.