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Microglia signatures in the hippocampus of Alzheimer's Disease and Dementia with Lewy bodies patients
Fixemer, Sonja
Worldwide more than 55 million people are suffering from incurable age-related neurodegenerative diseases and associated dementia, including Alzheimer's Disease (AD) and Dementia with Lewy bodies (DLB ... [more ▼]
Worldwide more than 55 million people are suffering from incurable age-related neurodegenerative diseases and associated dementia, including Alzheimer's Disease (AD) and Dementia with Lewy bodies (DLB). AD and DLB patients share memory impairment symptoms but present specific deterioration patterns of the hippocampus, a brain region essential for memory processes. Notably, the CA1 subregion is more vulnerable to atrophy in AD patients than in DLB patients. However, it remains unclear which factors contribute to this differential subregional vulnerability. On the neuropathological level, both AD and DLB patients frequently present an overlap of misfolded protein pathologies with AD-typical pathologies including extracellular amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein (pTau), and DLB-typical pathological inclusions of phosphorylated 𝛼-synuclein (pSyn). Recent genome-wide association studies (GWAS) have revealed many genetic AD risk factors that are directly linked to microglia and suggest that they play an active role in pathology. However, how microglia alterations are linked to local pathological environments and which role microglia subpopulations play in specific vulnerability patterns of the hippocampus in AD and DLB remains poorly understood. This PhD thesis addressed two main aspects of microglia alterations in the post-mortem hippocampus of AD and DLB patients. The first study provided a very detailed and 3D characterization of microglia alterations at individual cell levels across CA1, CA3 and DG/CA4 subfields; and their local association with concomitant pTau, Aβ and pSyn loads across AD and DLB. We show that the co-occurrence of these three different types of misfolded proteins is frequent and follows specific subregional patterns in both diseases but is more severe in AD than DLB cases. Our results suggest that high burdens of pTau and pSyn associated with increased microglial alterations could be associated to the CA1 vulnerability in AD. Our second study provided an morphological and molecular characterization of a type of microglia accumulations referred to as coffin-like microglia (CoM), using high- and super-resolution microscopy as well as digital spatial profiling. We showed that CoM were enriched in the pyramidal layer of CA1/CA2 and were not linked to Aβ plaques, but occasionally engulfed or contained NFTs or intraneuronal granular pSyn inclusions. Furthermore, CoM are not surrounded by hypertrophic reactive astrocytes like plaque-associated microglia (PAM), but rather by dystrophic astrocytic processes. We found that proteomic and transcriptomic signatures of CoM point toward cellular senescence and immune cell infiltration, while PAM signatures indicate oxido-reductase activity and lipid degradation. Our studies provide new insights in complex signatures of human microglia in the hippocampus of age-related neurodegenerative diseases. [less ▲]
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My first-ever blog post | Maplehurst Quilt Co.
So, I've finally been dragged beyond the world of Facebook into the blogosphere. Just a little about me: I am absolutely passionate about quilting, my human and furry family, and all of the great things about living in Kentucky (not necessarily in that order). Most of what you will see here will be about quilting – design, piecing, applique, and quilting the finished top. I have my own home-based longarm machine quilting business, Maplehurst Quilt Co., and I am also fortunate to work at Quilted Joy (www.quiltedjoy.com), the Louisville APQS dealership owned by the fabulous quilter and teacher, Angela Huffman. I have taught various aspects of quilting locally over the past ten years and currently teach the basics of using longarm machines to newly-minted renters.
One particular item of note is the upcoming Row by Row Experience for 2016. I haven't seen the final count of shops participating this year, but they represent all fifty U.S. states, all of the Canadian provinces (and two of the territories), and several countries in Europe. Each shop has designed its own original row, 36″ wide by 9″ high, so that you may visit the shops, collect the designs, and assemble them into a quilt or quilts. Here is a sample (look for Colleen's 2015 Row by Row quilt): http://www.quiltedjoy.com/2016/04/renters-give-free-motion-a-try.html How I wish I could visit each and every store! To learn more about the Row by Row Experience, including locations of shops near you or close to your planned summer travels, visit their main page at www.rowbyrowexperience.com and click on the Start Here! tab. The fun begins on June 21!
My plan is to post at least once a week, most likely on Wednesdays, to let you know what has captured my attention or interest. Talk to you soon!


Whilst on exercise the Lifeboat was diverted to assist persons in the water half a mile off Clarach Bay. Two people had fallen of a Jet-ski but when the lifeboat arrived it was already under tow into the beach and casualties had been recovered. Lifeboat escorted casualties into the beach where they were met by Aberystwyth Coastguard.


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Surgery is not normally indicated for most patients, but may be necessary for athletes in order to help them fully recover. The ligament is reconstructed using another ligament from the patient's own body (autograft), most likely from the forearm, hamstring, or knee. The palmaris longus tendon is a commonly used replacement, and it is threaded through holes drilled by the surgeon in a figure-8, thus ensuring adequate tension.


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Federal Court hearing landmark challenge on indefinite immigration detention | CBC News Loaded
Federal Court hearing landmark challenge on indefinite immigration detention
A challenge to Canada's immigration laws gets underway in Federal Court in Toronto today, with lawyers for Alvin Brown, who was held for years before his deportation to Jamaica last fall, arguing that indefinite immigration detention violated the constitutional rights of Brown and hundreds of others.
'I remember the shame ... We weren't allowed to talk about it. There was so much stigma,' says ex-detainee
Shanifa Nasser · CBC News · Posted: May 15, 2017 5:00 AM ET | Last Updated: May 15, 2017
On Monday, the Federal Court of Canada will hear the first-ever constitutional challenge to the regime, according to Jared Will, lawyer for Alvin Brown. (Peter Macdiarmid/Getty Images)
A challenge to Canada's immigration laws gets underway in Federal Court in Toronto today, with lawyers for a man held for years before his deportation to Jamaica arguing that indefinite immigration detention violated his constitutional rights and those of hundreds of others.
Alvin Brown, 40, spent five years in maximum-security provincial jails before he was deported last fall.
His lawyers, including Jared Will, launched the landmark constitutional challenge two years ago, calling on the government to justify the practice of indefinite immigration detention.
Monday's case is believed to be the first-ever charter challenge to the practice, according to Will.
Brown came to Canada as a child with his family and lived here for more than three decades before being removed last fall for a series of criminal convictions. Will said Brown had also been battling addiction and mental health issues.
Brown had first languished behind bars because of a series of delays by the Canada Border Services Agency (CBSA) and Jamaican authorities in processing his deportation.
Jamaican Alvin Brown finally deported but damages urged for his 5-year immigration detention
Immigration detainee freed after being held in Canada for 7 years due to 'legal limbo'
He was still in custody when his lawyers first filed the challenge, which is proceeding despite his deportation.
"We talk to people in this situation and the first thing they tell you is that the hardest part is that they don't know how long they're going to be there — day after day after day without knowing," said Will.
He argues the practice violates Canada's Charter of Rights and Freedom protections against indefinite and arbitrary detention, as well as cruel and unusual treatment.
Hundreds in detention in Canada
The CBSA was asked for its position on Monday's challenge, but has yet to respond.
However, according to the agency, there are some 450 to 500 people in detention in Canada under the Immigration and Refugee Protection Act at any given time. Since 2000, a total of 15 have died in custody, according to the advocacy group End Immigration Detention Network (EIDN).
EIDN representative Nisha Toomey points to clear limits to the practice in the European Union and in the United States. In the EU, detention is capped at six months with the possibility of extending to 18 months in certain cases. In the U.S., the period of presumptive release is six months, subject to exceptions, such as for dangerous individuals.
The United Kingdom, New Zealand and Australia do not have prescribed maximum lengths for immigration detention, Ministry of Public Safety spokesperson Scott Bardsley said, adding that the office could not comment further since the case is before the courts.
Kimora Adetunji says she was detained with her family upon arriving to Canada in 1992 at age eight. She says the shame of the experience remains with her even 25 years later. Her husband is now in detention after coming to Canada without authorization and has been held for the past nine months. (Paul Smith/CBC)
In Canada, a person can be detained if the CBSA believes that person is inadmissible under the Immigration and Refugee Protection Act, poses a danger to the public, is unlikely to appear for a hearing or removal date, or cannot prove his or her identity to the officer's satisfaction.
It doesn't fit with who we are as Canadians. - Kimora Adetunji , former detainee
That last criterion in particular, critics argue, can leave the majority of non-criminal detainees in detention for an unlimited period of time, a practice that Canada has come under fire for by the United Nations human rights committee.
It's a problem Kimora Adetunji, who is married to a current detainee being held in Toronto, knows all too well.
Adetunji said she was detained at age eight with her family after they arrived in Canada in 1992.
"I remember the shame … Afterwards we weren't allowed to talk about it, there was so much stigma," she said. But after 25 years in Canada, she says, she was shocked to learn the practice is still in place.
'Every 30 days, it's the same answer'
Like all detainees, Adetunji's husband undergoes a review by the Immigration and Refugee Board every month.
"Every 30 days, it's the same answer," she said. "It's almost as if it's a circus, that we're going there just so that they can say they offered him the opportunity to have a detention review."
Jared Will, lawyer for Alvin Brown, argues that indefinite immigration detention violates Canada's charter protections, and constitutes cruel and unusual treatment. (Paul Smith/CBC)
After the challenge is heard Monday, Will said, the case will likely be taken under reserve, with a judgment possibly months away.
But he's hopeful.
Last month, the Ontario Superior Court freed one of Will's clients who was one of Canada's longest-serving detainees.
Kashif Ali, a West African man who had no documentation and had amassed a string of convictions dating back to the 1990s, found himself in legal limbo in detention for some seven years.
In his ruling, Justice Ian Nordheimer called Ali's ordeal "unacceptable," rejecting the notion that his convictions were grounds for ongoing detention.
'An opportunity for us to change'
For its part, the federal government has said it's committed to making detention a last resort, and has launched consultations with the goal of developing a national immigration detention framework.
Last August, amid mounting pressure to respond to concerns about the practice, Public Safety Minister Ralph Goodale announced $138 million would go into improving Canada's immigration detention centres, which have been criticized for being understaffed and subjecting detainees to significant periods under lockdown.
Last August, amid mounting pressure to respond to concerns about the practice, Public Safety Minister Ralph Goodale announced $138 million would go toward improving Canada's immigration detention centres, saying detention should be a last resort. (Adrian Wyld/Canadian Press)
Will said that was "certainly not a welcome response."
"When you have the problem of people being detained for too long and under arbitrary and cruel conditions, to spend more money so that you expand your capacity to detain people isn't exactly a solution to the problem," he said.
Adetunji said that until the practice ends, her life and that of her husband remain in limbo.
"It doesn't fit with who we are as Canadians. There is an opportunity for us to change it and treat people better."
With files from Adrian Cheung
Ex-detainees, supporters form human chain demanding end to indefinite immigration detention
Canada's immigration detention program to get $138M makeover

redpajama_set_name: RedPajamaCommonCrawl


Are you or do you know Marina Warner?
Marina Warner is a published author and an editor. Some of the published credits of Marina Warner include Wonder Tales: Six French Stories of Enchantment, The Lore and Language of Schoolchildren (New York Review Books Classics).
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The Callisto Protocol Devs Want To Use PS5 DualSense Features To Scare Players
Ali Haider January 12, 2021
If you're a fan of the phenomenal Dead Space series of games, then you're probably aware by now of the existence of the upcoming The Callisto Protocol.
But for those not in the know as of yet, this is the next game being developed by Glen Schofield, who is one of the two co-creators of the Dead Space series. His new game was announced barely a month ago at The Game Awards 2020, and sadly, it seems to have gone under the radar of a lot of people.
The legend himself is working on this game with his new Striking Distance Studios, and according to the February 2021 issue of the Official PlayStation Magazine UK, his team is considering implementing PS5 DualSense features into the title.
Callisto Protocol DualSense Features
Nothing is finalized right now, but Glen Schofield has mentioned that they're looking into how to deliver scares through the DualSense haptic feedback.
He also spoke a bit about the level of graphical fidelity afforded by modern hardware and the new current-gen consoles, saying that:
What we're building, right? It looks real. And, you know, they've looked real before, but it looks more real. There's so much detail we can put into it now, it's crazy. – Glen Schofield.
He's talking purely about how far the look and feel of video games have evolved over the years, and how the game they're developing looks more realistic than anything they've ever made before.
Readers can check out the Official PlayStation Magazine UK Issue 184 for themselves if they want to learn more. The interview goes into much more detail about the setting of the game and the work being put into it by Striking Distance Studios.
The Callisto Protocol is set to release in 2022 on the Xbox Series X/S, PlayStation 5, and the PC.
Twisted Voxel would love to have your support if you enjoy our content. You can help us by subscribing to our channel on YouTube, following us on Twitter, and liking our page on Facebook.
Striking Distance Studios
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ESBE — her first video; plus more music is to follow...
Esbe has so far released two albums — Desert Songs, and Mystra — which have seen her music compared to Kate Bush and The Cocteau Twins. She is self-produced, and her production has the filmic qualities associated with for example Max Richter and Anne Dudley. Esbe's vocals have been compared to Lisa Gerrard and Liz Frazer.
Latest news: Due next are two albums titled Ten Songs and Far Away, to be released simultaneously, date TBC.
Meanwhile here is a taster — Esbe's striking first video. The song Don't Believe is from the upcoming album Ten Songs...
"It's filmed on location in a little house in London's Hampstead. The lyrics are about waking to an ordinary day, thinking of your lover, who has left – for the day? Forever? But Don't Believe hints optimistically that when you have love, it is really far from an ordinary day," says Esbe.
Two radio sampler EPs are also available: Sampler and Hope.
* Please contact us now for copies of albums, EPs, and more info...


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Džibuti (, , ) je hlavní a největší město Džibutska, které má současně status samostatného regionu. Leží na poloostrově oddělujícím Adenský a Tadžurský záliv. Obyvatelstvo čítá přes 500 000 lidí. Město je historicky rozděleno na evropské a africké čtvrti. Ve městě žije 70 % obyvatel Džibutska.

Historie
Město bylo založeno jako námořní přístav v roce 1888 Kataláncem jménem Eloi Pino. V roce 1891 se stalo namísto Tadžúry hlavním městem Francouzského Somálska a zůstalo jím po celou dobu francouzské koloniální nadvlády. Po vzniku samostatného Džibutska bylo zvoleno za hlavní město nového státu.

Doprava
Letecké spojení do Džibuti je zajištěno díky mezinárodnímu letišti Džibuti-Ambúlí, do etiopské Addis Abeby se lze dopravit rovněž po železnici a vnitrostátní dopravu do měst Tadžúra a Obock zajišťují trajekty z městského přístavu.

Zajímavosti
 Pláže na východním pobřeží města
 Hlavní trh
 Národní stadion Stade du Ville
 Prezidentský palác
 Hamúlího mešita

Podnebí
Džibuti má jedno z nejteplejších a nejsušších podnebí na světě. Průměrná roční teplota je 30 °C. V létě teploty stoupají nad 42 °C, v noci neklesají pod 30 °C. Nejstudenější měsíce jsou prosinec, leden a únor s průměrnými teplotami 25 °C ve dne i v noci.

Průměrná teplota (den i noc) v jednotlivých měsících

Aktuální teplota v Djibouti

Partnerská města
  Chartúm, Súdán
   Kailua, Havaj, USA
   Key West, Florida, USA
  La Paz, Mexiko
  Male, Maledivy
  Rimini, Itálie
  Saint Paul, USA
  Suez, Egypt
  Victoria, Malta

Odkazy

Reference

Externí odkazy

Geografie Džibutska
Hlavní města v Africe
Sídla založená roku 1888

redpajama_set_name: RedPajamaWikipedia


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Your students and children can cut them into shapes, then stick them on the windows and doors as decorations. They can be removed or repositioned over and over in your classrooms and childcare centers. Simply cut to length or shape for a custom art project, then apply.
No more worries about spills, tears and stains on your classroom shelves and table tops. Multipurpose decorative covering is tough, durable and repels stains. They will wipe clean easily too.


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I'm not Partisan, I'm Opinionated
The folks over at Tapped (weblog of the American Prospect) make an excellent point about the difference between being a partisan and having an opinion. They are very seperate entities. To boot:
Can we get something straight here? There is a difference in kind between "partisan" and "opinionated." In fact, in a political context, these words often mean the opposite. True political partisans say whatever is best for their party. They don't have any opinions of their own, merely a line of the day. A journalist with an opinion is, one hopes, someone who has gathered enough facts to come to a conclusion about whatever it is they're writing about. You can be opinionated without being a partisan, and you can be partisan without being opinionated. (Nor is partisanship proportional to ideological fervor: You can be highly partisan as well as centrist, as Tom Daschle was, or highly conservative and also bipartisan, as John McCain is. Why is this so hard to understand?)
I try my best to be opinionated, not partisan. To be clear, my opinions tend to lean Liberal. Does that make me partisan? I don't think so, because I evaluate issues independent of what the Democrats say on the matter. If you don't think that's true, then you can think I'm a partisan. That's fine. All I'm saying is that I do my best to be as non-partisan as I can, and call the issues as I see them. And all I expect of my colleagues in the blogosphere is that they do the same.
This issue is important to me, because I think it aptly synthesizes a couple of very core beliefs I hold. When one has opinions, rather than blind faith in a party, it makes for a stronger Democracy. The tendancy of people to substitute party affiliation in place of actually thinking about and discussing issues of importance to our nation is extraordinarily damaging to democracy as a whole. At the same time, the people can't take all the blame. Partisan politicians are every bit as bad, in fact they're worse, because they feed the cycle and actively prevent the nation from breaking out of its hyperpolarized mindset. Hence the anger bordering on rage I feel towards Tom DeLay and his ilk. People like him are ruining the country. I pray for a day when we have more McCains and Liebermans in office, and the DeLays and Roves and Moores of the world are off writing wingnut blogs like they should be. But the key point is that one can still hold deep, abiding, sincere convictions, and fight for those convictions, without turning into a reckless partisan. John McCain is a perfect example. Chuck Hagel, Joe Biden, and Barack Obama are others. These men are models that the rest of us should hold ourselves up to, and I think it's in keeping with the ethical standard I hold myself to as well.
Odds and Ends, and a Slice of Optimism
First off, I'm going to judging at the Apple Valley debate tournament this weekend. So no blogging from Friday till Monday. I probably could use the break. And listening to dozens of high schoolers talk and argue intelligently about democracy promotion is real break from election watching (the sad thing is, I'm serious. It's been awhile since I've been able to see anything substantive on the topic).
Now, some more post-election thoughts, responding to the commenters on the last post. A lot of people argued that democrats were in trouble with "value voters," IE the famous "God, Guns, and Gays" crowd. They're absolutely right. As Noam Schieber reminds us, the Conservative vote came out in force this election, with 34% of the electorate describing itself as Conservative (compared to 29% in 2000). That's a huge shift. What's more, according to polling the most important issue for voters this election wasn't Iraq, or the Economy, or Terrorism. It was "Moral Values" (edging out "economy" 22-20). To paraphrase Andrew Sullivan: For Bush's base, it wasn't about the war on terror. It was about the war on gay unions.
All of this, I think, only reaffirms my point though. The "moral values" issues probably have the least substantive discussion of any major campaign issue. You never see a real debate about gay marriage or abortion. Republicans just say "GAY PEOPLE!" and voters run screaming to the polls, while Democrats just try and play damage control. In other words, 1) Bush won due to 2) "values-voters" who 3) are voting off issues that get no discussion beyond bumpersticker platitudes. Style 1, Substance 0.
So to win, the Democrats either have to shift the ground of debate onto areas where they have stronger platitudes, or they need to push the debate beyond cute sound bites. Not only do I find the former morally abhorrent, but I think that it won't work. Abortion and gay marriage are important concerns for many people, and Democratic efforts to ignore them are likely to backfire. And yet, the latter option is a paradox. As former guestblogger Greg Ihrie points out, the mainstream media presents an irreconcilable obstacle to these goals. I think that, in the long term, blogs may counter the influence of the MSM. But what are to do in the short run, when it appears that voters care more about isolating gays and lesbians than annihilating Al-Qaeda? At times it seems we need a silver bullet.
And yet, hope remains. Today, polarization has divided America into Republican and Democrat. Politicians get votes by appealing to the worst in voters. We face grave threats abroad, and yet we fight amongst ourselves at home. Honest disagreement is presented as betrayal, the slightest hint of bipartisanship is seen as traitorous. I do not argue that Americans must ignore legitimate grievances. The solution to partisan vitriol is more speech, not enforced silence. The politics of deceit and deception; bigotry and apathy; prejudice, fear, hate, and anger, can only win out for so long. In the long run, justice will reign in this great land. In place of fear, we can offer hope. In place of bigotry, we can offer brotherhood. In place of partisanship, unity, in place of factions, community, in place of lies, honesty. The legions of justice stand battered but not broken. There is a better way out there, and it is up to us to seize the initiative. And when the gauntlet is thrown down, we will meet the forces of wrong, fight them, beat them, and stand victorious in a stronger, safer, more just America. In cities and in towns, villages and in hamlets, in farms and in apartments, from young to old,Democrat to Republican, Christian to Jew to Muslim to Atheist, black or white, rich or poor, gay or straight, north, south, east, west and all over this great land, we will not be silenced, we will not be quiet, we will not equivocate, and most of all we will not be ignored.
There is hope yet for America. It is a hope based on what binds this nation together as one. The principles of liberty for all, justice for all, equality for all, are what unite this country together as the greatest country in the world. Barack Obama said it best: "The pundits like to slice-and-dice our country into Red States and Blue States; Red States for Republicans, Blue States for Democrats. But I've got news for them, too. We worship an awesome God in the Blue States, and we don't like federal agents poking around our libraries in the Red States. We coach Little League in the Blue States and have gay friends in the Red States. There are patriots who opposed the war in Iraq and patriots who supported it. We are one people, all of us pledging allegiance to the stars and stripes, all of us defending the United States of America." And I believe that, whether or not the standard bearer is a Republican or Democrat, a Liberal, Conservative, or Independent, the day of reckoning draws upon us. The era of hate is over. The American people will not let their government, their churches, their synagogues and their mosques be hijacked in the name of exclusion and bigotry. The party of Abraham Lincoln, who freed the slaves, and Dwight D. Eisenhower, who desegregated the schools, and of Anthony Kennedy, who affirmed that yes, Gay people too are full and equal Americans, cannot be allowed to become the party of Jerry Falwell, Tom DeLay, Pat Robertson and others who wish for a divided, infighting, spiteful America. There is too much at stake for that, and Republicans and Democrats of wisdom and moderation must reach out and fight back the forces of intolerance that threaten to overcome our nation. We will prevail, because we must prevail.
In the coming four years, I hope that Americans can work together, Republican and Democrat, across party lines, for the good of the country we all love so much. I pledge my support to any politician, no matter the party, who will stand beside me and work with me in the pursuit of justice. We owe it to our parents, we owe it to our children, we owe it to our country, to make America all that it can be. Much has been accomplished, but much remains to be done. The hope of America lies in the hands of the millions of American citizens who remain committed to our founding ideals, the ideals that shine as a beacon of hope to oppressed peoples around the world. And so, now more than ever, God Bless the world, God Bless the Democrats, God Bless the Republicans, and God Bless America!
Post-Mortum
I'm going to write as honestly as I can in this post. Since we're in the immediate aftermath of a bitterly fought election, it may come off a bit raw. All I can say is that I hope I've purchased enough moderate credibilty that you can all indulge me for awhile. And since it seems only Republicans read my blog, please no mocking. I'd do the same for you. Here are my thoughts on how this election will impact everybody:
Well, my forecast of an impending GOP civil war has been forestalled, at least for now. In the long run, I think my prediction still holds true: The GOP's mismatched coalition simply can't last much longer. But election day victories work wonders for keeping status quo alliances intact.
The real question is how Bush will govern in his second term. Part of me wants to think he'll be a bit more sensible, in part because it would be hard not to, and in part because without the need to win another election, there isn't any reason to keep playing the pander game. But a much greater part of me is pessimistic, since without an impending election to keep him honest, there is nothing pushing Bush to the center. It seems unlikely that Bush would have risked so much in polarizing America by governing from the right, if he would have been content to be a centrist. Furthermore, even more than 2000 or 2002, this election has given Bush a semi-solid mandate to continue his policies. This shouldn't be taken as a vindication of these policies, the relevant morality or advisibility of any given action exists independent of its electoral popularity. But Bush and the Republicans will almost certainly use this election as an excuse to make even more radical changes in our society. This is their right, and I don't contest it. But I don't have to be happy about it either.
An unmitigated disaster. We lost key senate races. We lost key house races. We lost the presidency. Right now, Democratic activists are so hung up on the idea of four more years of Bush I think that they haven't even noticed just how bad of a shape we're in. I think the prevailing mood amongst Democrats was that the worst-case scenario for us was that we'd maintain the status quo: IE, Bush would still be president, and the house and senate would stay in approximately the same margins as they were before. But it looks like we're going to be worse all the way around.
Not only that, but this whole election is devastating to Democratic morale. In 2000, we had righteous anger driving us after Florida. We kind of lost a step after 9/11, and got nailed in 2002. But I think everyone thought that the Democratic machine was going to make a roaring return as a relevant player in the political process. We threw everything we had into this election, and we still lost. Whereas we had that drive and determination after 2000, all I see now is despair and hopelessness in the eyes of the Democrats around here. The electoral map is slanted against us, our best turnout efforts failed to win contested races, and in many cases 2004 was our only chance to win these races (does anyone think the Oklahoma Senate spot will be competitive again anytime in the next, oh, 35 years?). This is really, really bad.
Here's where I start to descend a bit, I think. First, let me say that for all appearances this election was reasonably fair. Sure, there were scattered reports of random this and that around, but on a whole, it does not look like there will be any Florida repeats. That's a positive by any measure.
I will say that I am extremely disillusioned at the moment. To gather why this is, allow me to share an anecdote. When I was in elementary school, we had elections each year for our school president, VP, secretary, treasurer, and class reps. And every year the principal would get on the intercom and remind us that "we should vote for who we thought would do the best job, not just your friends." And we'd all kind of chuckle, because we knew that everyone just voted for their friends and no one gave the slightest thought to who would do a better job. But I thought, and I think we all thought, that this was because we were kids, and when we were grownup then we would look at the candidates seriously and make decisions based on issues and hard analysis.
Fast forward to 2000. In 2000, I was still a hyperliberal, not the center-leftist I consider myself now. I watched an election race where the biggest issue was that Gore was "too brainy" and Bush was "folksy" and "an average Joe." I was totally in shock. What the hell did "folksiness" have to do with Presidential qualification? Why was being smart considered a disadvantage, of all things? It was like the voters were all 10 years old again. In the first presidential race I followed carefully, I was dismayed to see virtually no attention paid to issues of substance, and hours upon hours of coverage dedicated to Gore's sighing or Bush's malapropisms. Why did I bother to inform myself on the issues, if issues were irrelevant to the process? It just didn't make sense to me.
Moving again to 2004. Towards the end of the election, I formulated a theory that matched my new centrist perspective. I argued to my friends that the majority of Americans weren't polarized archenemies. Rather, we had alot of disillusioned moderates angry that both parties appear to make decisions based solely on political concerns. The particular voting tendancies of these moderates was based around which party better dealt with their "pet issues," but as a whole, they were unhappy campers who wanted to see a third way. In light of this election, I revise that theory to incorporate my thoughts in 2000. The majority of Americans consider themselves moderates, but they aren't concerned with issues. They care about style. They want a candidate who matches their style, who makes them feel good. What did Clinton and Reagan have in common? They both made Americans feel good about themselves again. Now, when things are going well, this is an asset. But in times of trouble, it creates a disturbing catch-22, where incumbants are encouraged to pretend that problems don't exist so that voters feel good about themselves, and stick with status quo. I understand the electoral reasons for this, but the point is its bad for the country. It's dangerous, and while some electioneering may be tolerable when we're just talking about pushing numbers around the budget, when we're fighting a war, when American lives are at stake, its simply not acceptable anymore to subordinate principle to politics.
If I'm a politician gathering lessons from this election (and the last), here's what I learn:
1) Style is 80%, substance 20%
2) The 20% substance should pander only to the base, since they're the only ones paying attention to the issues anyway.
What does this give us? A political system that encourages and rewards personal sliming, politics of demagogery, and substantive extremism. That frightens me. What frightens me more is that I don't see a way to counteract it. It might very well be inherent to democracy. This election saw an unprecedented effort toward the politics of personal destruction, but it also gave voters more resources on which to learn about issues than ever before. From the blogosphere to Factcheck.org, the ability to learn about the world around us and the truth about political issues reached incredible heights. Groups went crazy trying to get out the vote, from ACT to Vote or Die. None this seemed to do anything. There is almost a willful resistance to anything that threatens America's well-entrenched ignorance. And I don't see anyway to stop it.
Before I get jumped on, I'm not denying it's possible to support Bush from a policy standpoint. It certainly is, and I'm sure there are plenty of principled, informed Bush supporters who weighed the facts and decided Bush was their man. All power to them. However, I think that it is indisputable that what put Bush over the top was not an agreement with his policies but an appreciation of his style. Americans want to put on a tough face against terror. We are resolved to win this war, and we want a leader who is an embodiement of that resolve. Noble qualities, for sure. But not substantive differences by any stretch. That's what I mean when I say these elections are decided on style. And no matter how many times Kerry says he's going to be resolved, and determined, when people get it in their heads that he's a weak-kneed flipflopper, they are going to be very reluctant to change that.
In my last post before the election, I made a pledge to support the president, even if I didn't vote for him. That pledge still holds. I wish President Bush the best, and hope he can lead America to a better tommorow. I don't know if there is any way to restore substance to politics. But I do pledge that my little corner of the political world will remain dedicated to intelligent, rational, and objective discussion of the issues, regardless of political origin. That is all I have to offer to America.
Post Election Pledge
I'll take this pledge* from Buzz Machine:
After the election results are in, I promise to:
: Support the President, even if I didn't vote for him.
: Criticize the President, even if I did vote for him.
: Uphold standards of civilized discourse in blogs and in media while pushing both to be better.
: Unite as a nation, putting country over party, even as we work together to make America better.
*Nothing in this pledge shall be construed to require me to support an unfair tallying of the votes. The Debate Link reserves the right to support post-election litigation to make sure all the votes are counted, pursuant to the democratic ideals that make our nation great. All rights reserved. Hat tip to Andrew Sullivan.
Posted by David Schraub at 2:03 AM No comments:
Final Election Prediction
UPDATE: 11/1 @ 7:00. West Virginia was a typo, I think Bush will win it (the electoral vote tally was right originally)
From now until we find out who our next President is (IE, sometime in December), I'll be having a slow, progressive heart attack. Before I succumb to immobility and the fetal position, here are my electoral predictions.
POPULAR VOTE: Kerry by less than 1%, +/- 1% (IE, it will be very close in either direction).
WHITHER THE STATES?
Alabama: Bush
Alaska: Bush
Arizona: Bush
Arkansas: Bush
California: Kerry
Colorado: Bush
Connecticut: Kerry
Delaware: Kerry
District of Columbia: Kerry
Florida: Kerry
Georgia: Bush
Hawaii: Kerry
Idaho: Bush
Illinois: Kerry
Indiana: Bush
Iowa: Kerry
Kansas: Bush
Kentucky: Bush
Louisiana: Bush
Maine: Kerry
Maryland: Kerry
Massachusetts: Kerry
Michigan: Kerry
Minnesota: Kerry
Mississippi: Bush
Missouri: Bush
Montana: Bush
Nebraska: Bush
Nevada: Bush
New Hampshire: Kerry
New Jersey: Kerry
New Mexico: Bush
New York: Kerry
North Carolina: Bush
North Dakota: Bush
Ohio: Kerry
Oklahoma: Bush
Oregon: Kerry
Pennsylvania: Kerry
Rhode Island: Kerry
South Carolina: Bush
South Dakota: Bush
Tennessee: Bush
Texas: Bush
Utah: Bush
Vermont: Kerry
Virginia: Bush
Washington: Kerry
West Virginia: Bush
Wisconsin: Kerry
Wyoming: Bush
FINAL TALLY: KERRY 306, BUSH 232
Keeping the fingers crossed...ackkk, my heart!
UPDATE: 10/31 @ 9:25 PM
Things just aren't working for us in Iraq. Newsweek reports (tip off: Kevin Drum) that we're in an even worse situation than has hither to been acknowledged. Quote:
"But the truth is, neither party is fully reckoning with the reality of Iraq—which is that the insurgents, by most accounts, are winning. Even Secretary of State Colin Powell, a former general who stays in touch with the Joint Chiefs, has acknowledged this privately to friends in recent weeks, NEWSWEEK has learned. The insurgents have effectively created a reign of terror throughout the country, killing thousands, driving Iraqi elites and technocrats into exile and scaring foreigners out. 'Things are getting really bad,' a senior Iraqi official in interim Prime Minister Ayad Allawi's government told NEWSWEEK last week. 'The initiative is in [the insurgents'] hands right now. This approach of being lenient and accommodating has really backfired. They see this as weakness.'
Washington has declared several times that the insurgency would soon be defeated or at least mostly neutralized. Senior officials made such statements when electricity was restored to its pre-occupation levels in 2003, when Saddam was captured in December, when sovereignty was handed over on June 28. Each time the insurgency has only grown. Now even military officials who are hopeful the insurgency can be defeated—or perhaps just reduced to a violent annoyance—say it will be a long haul no matter who is U.S. president.
We've got a mess on our hands, no doubt about it. And yet, inexplicably, some trust the man who caused the mess to get us out of it. Presumably, if Bush had a plan to fix Iraq, we'd have seen it by now. That Iraq is still mired in an insurgency, indeed, that the insurgency has only grown as time has passed, is a powerful indictment against the Bush administration.
UPDATE: Daniel Drezner also runs with this issue for awhile. Specifically, he uses it to utterly dismantle the Chicago Boyz's (by way of Instapundit) claim that Bush has done a great job on this war. They write:
Now the one thing that strikes me about the military efforts to date is just how incredibly successful they've been, and how masterfully planned and executed they turned out to be. Not perfect, of course (You mean there's terrorists setting off explosives? Against Americans and their supporters? In the Middle East, no less? Say it isn't so!). But a lot of the toys that John Kerry voted against turned out to be damned useful in the War on Terror. I don't want to even think about how an Afghanistan operation with Vietnam-era technology and tactics would have gone for us - I think in that case we'd have been wishing for another Vietnam. And if you've ever cracked a history book, you'll realize that only 1200 deaths in a year and a half of invading a dictatorship, overthrowing its dictator, and fighting a chronic insurgency is astoundingly good news, especially when added to the fact that the long-predicted flood of refugees never materialized, the terrorists that Saddam's regime had nothing whatsoever to do with suddenly got extremely interested in the fate of Iraq . . . and Iraqis are still signing up to take on the battle for their country against these thugs and getting set to vote in their first-ever real election in a couple of months.
And the Commander-in-Chief at the helm during these amazing accomplishments is called incompetent? You've got to be kidding me.
Drezner notes that
"There is one point in this narrative on which I absolutely agree -- the observable costs of the insurgency in Iraq, measured in either men or material, is nowhere near the cost of what transpired in Vietnam. We're talking about differences by several orders of magnitude.
There is, of course, the question of unobservable costs -- and read Ambassador Peter Galbraith's disturbing account in the Boston Globe on that issue.
More importantly, there is the question of trend -- are things betting better or worse in Iraq over time? And here's where I part company with the above narrative."
He then quotes from the above Newsweek article to illustrate this point. The point that I think is relevant here is this. Whether or not Bush has done a good, or even remotely competent job of fighting this war goes beyond simple body counts. Whether or not we are "succeeding" in Iraq is a direct function of how likely it is that country is going to end up as a stable, functional democracy. If it becomes a new haven for terrrorists, then we are losing even if we don't incur a single new casualty. If it replaces its old dictator with a new dictator, we've failed even if we don't incur a single new casualty. The proper measure of Bush's policies in post-war Iraq is whether or not they've been facilitative of our goals for the region: Democratization and Anti-terrorism. The fact is, they haven't been. They haven't been because our hubris has turned the local population against us. They haven't because our spurning of offered international assistance has reinforced the perception that this is an imperial mission. They haven't because the interim government loses credibilty every time it identifies itself with the US. They haven't because increasingly, democrats in the region like Ayatollah Ali Sistani are viewing the US as an obstacle, rather than an aid, to democracy. They haven't because the situation in Iraq has deteriorated to the point where the National Intelligence Estimate foresees a reasonable chance that the country will fall into civil war. All of these issues are problems for which the Bush administration can, and must, be held culpable for.


text:
Calirritimia, no contexto, do ensino de música no Brasil nas décadas de 1930 e 1940 corresponde à preparação do aluno no ajuste de cada palavra do texto com o ritmo da música. Na proposta de Heitor Villa-Lobos, a calirritmia é uma das finalidades do canto orfeônico, junto à califasia e a califonia

Origem do conceito
Para a compreensão do conceito de  calirritimia  é preciso identificar a utilização do conceito entre as décadas de 30 e 40 no  Brasil.  Neste período este termo foi empregado por Heitor Villa-Lobos em seu curso de Canto Orfeônico, porém isto não quer dizer que esta definição tenha sido criada pelo Educador Musical. Esta problematização  é importante, já que este termo também era adotado em cursos de oratória e em estudos sobre os distúrbios da voz na área da saúde. Um exemplo desta utilização diversificada, é o Manual de califasia, califonia e calirritimia e a arte de dizer de Francisco da Silveira Bueno publicado pela primeira vez em 1933.  Até hoje esta bibliografia serve de referência para estudos na área da saúde, como por exemplo a fonoaudiologia. Heitor Villa-Lobos, como  outros profissionais, de diferentes campos do conhecimento, usufruiu desta definição, vista, em sua época, como um adjetivo que caracterizava uma prática que buscava primazia,  no qual era desenvolvida para o alcance dos objetivos específicos propostos por cada uma destas áreas.

:Categoria:Educação musical

Educação musical
Heitor Villa-Lobos


Announcement Look for new yarn listings within the next week! Lots of new things coming to Big Kate's including new 100% angora yarn and some tweeds as well as some alpaca and Jacob sheep yarns!
Look for new yarn listings within the next week! Lots of new things coming to Big Kate's including new 100% angora yarn and some tweeds as well as some alpaca and Jacob sheep yarns!
Soft, cuddly, warm and well-made!
Beautiful! Well worth the wait. Thanks for the extra!
Kate's knit caps are so lovely; the wool is lush and the colors vibrant. This is a must shop for quality and price... please stop by!
Things made for Big Kate's are actually little pieces of my stress turned into something beautiful. I create to unwind. My shop is a way to move my stress on and possibly bring a little joy into someone else's life. If one of my pieces makes someone else happy, then it's worth every second of stress that led to its creation. Thanks for visiting my shop and I hope to see you again soon!
Kate has been crocheting and knitting for about 25 years. It all started with a little piece of string and watching her grandmother and her hook. Lots of love goes into every piece she creates.
Cameo is a going-on-16 young lady who likes to create things almost as much as her mother! Her medium tends to be beads and wires. She is my little jewelry maker! She also helps throw colors in my dye pot at times! A super helper!
Welcome to Big Kate's Hand-crafted Things!! Each of my items are hand-made with love and I hope that you enjoy them as much as I enjoyed making them!
Paypal and Major Credit Cards.
Your item will get shipped when I receive payment, not before. I ship Monday thru Friday; so if you buy something from me on Saturday it will not get shipped until Monday. NO INTERNATIONAL SHIPPING. Continental US only.


text:
Bruce Molsky
by Jalopy Theatre
Sat, 21 August 2021
Jalopy Theatre
315 Columbia St
Organizer Jalopy Theatre
He's a self-described "street kid" from the Bronx who bailed on college and big city life for a cold-water cabin in Virginia in the 1970s. His mission? To soak up the passion that was dramatically upending his parent's life plan for him – authentic Appalachian mountain music – at the feet of its legendary pioneers, old masters who are now long gone.
Today, Bruce Molsky is one of the most revered "multi-hyphenated career" ambassadors for America's old-time mountain music. For decades, he's been a globetrotting performer and educator, a recording artist with an expansive discography including seven solo albums, well over a dozen collaborations and two Grammy-nominations. He's also the classic "musician's musician" – a man who's received high praise from diverse fans and collaborators like Linda Ronstadt, Mark Knopfler, Celtic giants Donal Lunny and Andy Irvine, jazzer Bill Frisell and dobro master Jerry Douglas, a true country gentleman by way of the Big Apple aptly dubbed "the Rembrandt of Appalachian fiddlers" by virtuoso violinist and sometimes bandmate Darol Anger.
Molsky digs deep to transport audiences to another time and place, with his authentic feel for and the unearthing of almost-forgotten rarities from the Southern Appalachian songbook. His foils are not only his well-regarded fiddle work, but banjo, guitar and his distinctly resonant vocals. From tiny folk taverns in the British Isles to huge festival stages to his ongoing workshops at the renowned Berklee College of Music, Molsky seduces audiences with a combination of rhythmic and melodic virtuosity and relaxed conversational wit – a uniquely humanistic, downhome approach that can make Carnegie Hall feel like a front porch or parlor jam session.
As 2016 unfolds, the ever-busy Molsky continues to pioneer new ground on several fronts. Summer will bring the debut disc by Molsky's Mountain Drifters, the first band the legendary fiddler has fronted. In Bruce's words, this release will "point to the future of traditional, rural music" powered by the far-ranging musical palates of his two youthful bandmates. Banjo virtuoso Allison de Groot of "The Goodbye Girls" and "Oh My Darling" met Molsky at one of his workshops at Berklee, where his interest was piqued when "she played Lester Young solos on claw hammer banjo." The band's third member, guitarist Stash Wyslouch, is one of bluegrass music's true genre benders, a high-energy performer who cut his teeth in punk and metal bands before immersing himself in roots music with "The Deadly Gentlemen."
The new "Can't Stay Here This a-Way" is a unique CD/DVD collection recorded in Los Angeles for Dave Bragger's Tiki Parlour series. Not a recording session in the traditional sense, Bruce just showed up, sat on a couch while the camera and recording device rolled – capturing all the spontaneity as he casually reeled off and provided insightful comments on traditional favorites and some new offerings. Also on the slate is, "Rauland Rambles" from Molsky and his Norwegian collaborators, Arto Järvelä and Anon Egeland. This distinctive recording, which fuses traditional American roots with Scandinavian folk, comes from an impromptu session set after Bruce performed at this year's Rauland International Winter Festival in Norway.
In addition to his many live performances as a solo and with Molsky's Mountain Drifters, Bruce will be kept away from his home in Beacon, New York, by his work as a Visiting Scholar at the old American Roots Music Program at the Boston's Berklee College of Music, and through fiddling workshops and summer music camps he conducts for devotees here and abroad.
Photo Credit: Irene Young
Jalopy will be following all state and city distancing and capacity guidelines, along with providing UV powered air filtration and adequate ventilation. We will also be requiring all who attend to show us proof of being fully vaccinated and it has been 14 days or longer since your final shot.
Attendees must follow all mask, distancing and hand washing guidelines when in attendance. If you are vaccinated in New York, we encourage you to use Excelsior Pass to prove your vaccination. Excelsior pass is an app for your phone that can hold your vaccination and testing data. Download Excelsior Pass in the apple store or on google play.
NOTE: We will also accept other forms of proof of vaccination from other states including CDC Vaccination cards (with photo id), etc


Wiki Leaks Gulen's Agenda - CHARTER SCHOOL WATCHDOG http://www.charterschoolwatchdog.
It looks like the people at WikiLeaks have trumped Gulen and his buddies with their own expose' of Gulen's agenda, and more specifically, what the Gulenist's are doing in Turkey and the United States in order to cement the "movement."
The Turkish newspaper, The Hurriyet Daily News, published the story about the "leak," on March 17, 2011. Pay particular notice to the references on the United States' perspective on Gulen and his cult, and its operations and political influence in the United States.
What is of particular interest is the way that Gulen managed to get so many "letters of reference" to win his green card appeal when he was first denied permanent residency in the United States.
And then jump to the parts about how the Gulenists have infiltrated the police and government in Turkey, and the suggestion that the United States government is helping Gulen solidify his stronghold in the Turkish government.
We found the part about the "brainwashing" of students that attend his schools to be a bit concerning. It's one thing to manipulate and pull the strings on his Gulenist puppets (they are willing participants), but we would like to make certain that the strings are severed when it comes to our children -- in our schools.
And we have to believe that with continued pressure to investigate the "benevolent spiritual leader," from Turkey, and his many followers, that maybe -- just maybe -- our government will reverse course and realize how truly dangerous this guy is, and finally take some action, which is long overdue.
The perspective of the United States on religious leader Fethullah Gülen and his international community has evolved over the years amid lobbying efforts by the group to change its image, the latest leaked diplomatic cables have suggested.
Though U.S. officials perceived the community as adhering to a "moderate Islam" model, they expressed concerns in the cables, the first documents released by WikiLeaks' new Turkish partner, about its perceived infiltration into the Turkish police and accusations of "brainwashing of students" at the community's schools around the world.
The confidential cables released by daily Taraf focus on U.S. diplomats investigating and analyzing the religious community and its actions, Gülen's meeting with the pope in 1998 and his stay in the United States, according to reports in the Turkish media Thursday.
The newspaper was set to release the original cables on its website late Thursday as the Hürriyet Daily News & Economic Review went to press.
Gülen went to the United States on a tourist visa and applied in 1999 for a permanent resident card, or "green card," which was denied. His lawyers took the matter to court and won the case, granting Gülen his card in 2008. A 2009 cable by former U.S. Ankara Ambassador James Jeffrey mentions that although Gülen's status in the United States is provided by a court decision, some circles that dislike him incorrectly believe it to be the result of the U.S. government's politics regarding Turkey.
The FBI was also asked for a document of "clear status" for Gülen but did not give it because it might be used for a public-relations campaign, according to a cable featured by Taraf. One 2005 cable said the Gülen community seems to be a "moderate Islam" model that keeps its distance from violence and terrorism and is not anti-Semitic. However, it is also mentioned that since the Gülen community is running a global mission of Islamism, it remains to be seen whether it will remain positive or not. The "brainwashing of students" was mentioned during an evaluation of the community's schools around the world.
The perception of Gülen changed, however, after U.S. diplomats looked further into the community and spoke to more people about its organization in Turkey, according to Taraf's coverage. Later reports said Gülen is not a Khomeini who wants to transform Turkey into another Iran. The problem of the Gülen community is not with secularism itself but Turkey's version of it, which wants to "control everything," the cables state. "The Gülen community members do not want to bring down the secular order in Turkey dramatically, they are after a change from within," one said.
The 2009 cable by Jeffery describes Gülen as a "political phenomena" in Turkey even he is "in exile" in Pennsylvania. It was also said the Gülen community is strong within the police force and in conflict with the military, which sees the group as an enemy.
"It is not possible to confirm the Turkish police are under the control of the Gülen community members, but we have not met anybody who denies it," one cable said. The Gülen-controlled media is supporting the investigation into the alleged Ergenekon coup plot and has resulted in many opponents of the ruling Justice and Development Party, or AKP, ending up behind bars, the cable stated.
Gülen met John Paul II in the Vatican in February 1998 upon an invitation from the pope. Taraf's story said the two people who helped arrange the meeting were Üzeyir Garih, a Turkish businessman of Jewish origin, and Georges Marovitch, spokesman for the Clerics Board of Turkey Catholic Communities, both known as close friends of Gülen. Garih was stabbed to death in Istanbul's Eyüp Cemetery in 2001 while Marovitch survived a murder attempt in Rome in 2007, when an unidentified assailant pushed him onto a train track. Both incidents left many questions unanswered, the Taraf story said.
Cable says Turkish PM perceived as 'liability' by Gülen movement.
Prime Minister Recep Tayyip Erdoğan is a "liability," members of the Fethullah Gülen community have said, according to a U.S. embassy cable recently released by WikiLeaks' Turkish partner, daily Taraf.
People are hesitant to reveal their actual opinions because they are afraid what they say could hurt them later, according to the cable.


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Development and Evaluation of a Quality-Controlled Ribosomal Sequence Database for 16S Ribosomal DNA-Based Identification of Staphylococcus Species
Karsten Becker, Dag Harmsen, Alexander Mellmann, Christian Meier, Peter Schumann, Georg Peters, Christof von Eiff
Karsten Becker
Institute of Medical Microbiology
For correspondence: kbecker@uni-muenster.de
Dag Harmsen
Institute for Hygiene, University Hospital of Münster, Münster
Alexander Mellmann
Peter Schumann
DSMZ—German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany
Georg Peters
Christof von Eiff
DOI: 10.1128/JCM.42.11.4988-4995.2004
To establish an improved ribosomal gene sequence database as part of the Ribosomal Differentiation of Microorganisms (RIDOM) project and to overcome the drawbacks of phenotypic identification systems and publicly accessible sequence databases, both strands of the 5′ end of the 16S ribosomal DNA (rDNA) of 81 type and reference strains comprising all validly described staphylococcal (sub)species were sequenced. Assuming a normal distribution for pairwise distances of all unique staphylococcal sequences and choosing a reporting criterion of ≥98.7% similarity for a "distinct species," a statistical error probability of 1.0% was calculated. To evaluate this database, a 16S rDNA fragment (corresponding to Escherichia coli positions 54 to 510) of 55 clinical Staphylococcus isolates (including those of the small-colony variant phenotype) were sequenced and analyzed by the RIDOM approach. Of these isolates, 54 (98.2%) had a similarity score above the proposed threshold using RIDOM; 48 (87.3%) of the sequences gave a perfect match, whereas 83.6% were found by searching National Center for Biotechnology Information (NCBI) database entries. In contrast to RIDOM, which showed four ambiguities at the species level (mainly concerning Staphylococcus intermedius versus Staphylococcus delphini), the NCBI database search yielded 18 taxon-related ambiguities and showed numerous matches exhibiting redundant or unspecified entries. Comparing molecular results with those of biochemical procedures, ID 32 Staph (bioMérieux, Marcy I'Etoile, France) and VITEK 2 (bioMérieux) failed to identify 13 (23.6%) and 19 (34.5%) isolates, respectively, due to incorrect identification and/or categorization below acceptable values. In contrast to phenotypic methods and the NCBI database, the novel high-quality RIDOM sequence database provides excellent identification of staphylococci, including rarely isolated species and phenotypic variants.
Journal of Clinical Microbiology Nov 2004, 42 (11) 4988-4995; DOI: 10.1128/JCM.42.11.4988-4995.2004
You are going to email the following Development and Evaluation of a Quality-Controlled Ribosomal Sequence Database for 16S Ribosomal DNA-Based Identification of Staphylococcus Species


Pursue a future in criminal justice administration.
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Additionally, students receive the support they need to succeed, including academic assistance, career services and helpful online resources. Enroll in a single class, work toward a degree or earn credit to transfer to an outside college. Please note, it is important to check with your educational institution to determine if credits are transferable.
Call 866.484.1815 to get started or request more information today.


text:
Crunchyroll, Toonami Team Up to Launch 'Mob Psycho 100' on Adult Swim (Exclusive)
This linear partnership is Crunchyroll's latest foray into television
Matt Lopez | October 26, 2018 @ 8:05 AM	Last Updated: October 26, 2018 @ 1:59 PM
Courtesy of Crunchyroll
Crunchyroll's programming will be available for viewing on Adult Swim beginning on Saturday, as AT&T's take over of Time Warner begins to take shape.
The anime-centric streaming company, which is owned by AT&T, has teamed with Toonami, an animation television block on Adult Swim, to premiere "Mob Psycho 100" starting October 27 at 11:30 PM.
This linear partnership is Crunchyroll's latest foray into television, which complements its recent TV block in Brazil with RBTV where the platform brought two series dubbed in Portuguese to the Brazilian anime community.
Also Read: WarnerMedia Announces Streaming Service Slated for 2019 Debut
The streamer, which has a global community of more than 40 million registered users and over 2 million subscribers, is owned by Ellation, which is part of Otter Media, a media company AT&T acquired full control over in August.
The partnership is one of the first examples of how AT&T is leveraging its new portfolio of content and distribution channels. It also could be an indicator of what's to come from the company as it relates to how WarnerMedia is working with Crunchyroll and VRV across linear and digital.
Earlier this month, the telco also announced it would be packaging several of its newly acquired WarnerMedia brands into one streaming service, which is expected to launch in Q4 2019
16 Hollywood and Media Deals With Saudi Arabia - and Where They Now Stand (Gallery)
A growing number of Hollywood and U.S. media companies have backed out of business deals with Saudi Arabia and the crown prince, known by his initials MBS, after Turkish officials concluded that journalist Jamal Khashoggi was murdered by Saudi operatives inside the Saudi consulate in Istanbul on Oct. 2.
Here is a list of Hollywood and media deals with Saudi Arabia -- and where they stand now.
British entrepreneur Richard Branson announced he would step down as chairman of Virgin Hyperloop, a planned supersonic transport system in the United Arab Emirates and other countries, CNBC reported.
The Harbour Group
Leading D.C. lobbying firm representing the Saudi government's interests, the Harbour Group, announced on Oct. 11 it was terminating its $80,000-a-month contract with the kingdom.
WME parent company Endeavor, one of Hollywood's top talent agencies, said on Oct. 15 it was preparing to withdraw from its $400 million financing deal with the Saudi Arabian government.
Actor Gerard Butler pulled out of a trip to Saudi Arabia to promote his new movie "Hunter Killer" following Khashoggi's disappearance.
'Davos in the Desert'
The New York Times, Bloomberg, CNN, CNBC, The Financial Times, Nikkei, The Los Angeles Times, Fox Business Channel, Viacom and The Economist are among the names that have withdrawn their sponsorship or canceled their appearances from the high-powered Future Investment Initiative conference in Riyadh, dubbed "Davos in the Desert," to be hosted by the Crown Prince and the kingdom's sovereign wealth fund in late October.
CEO Dara Khosrowshahi said he was "troubled by the reports" and would not attend the conference "unless a substantially different set of facts emerges."
The movie theater chain has plans to open 40 theaters in the kingdom within the next five years, with the aim to reach 100 locations by 2030.
AMC declined to comment when reached by TheWrap.
Penske Media Corp.
In February, Penske, which owns Hollywood trades Variety and Deadline, among other publications, received a $200 million investment from Saudi Arabia's Public Investment Fund. The company declined to comment about whether it will reassess the investment.
WWE, which is due to return to Saudi Arabia on Nov. 2 for its "Crown Jewel" wrestling event, told TheWrap in statement that it's "currently monitoring the situation." An insider also told TheWrap WWE talent have been instructed to promote the event -- but not its location -- for two weeks now.
Plans for IMAX to build more movie theaters in the kingdom, which have been mired in red tape, will likely be put on "pause" following Khashoggi's disappearance, according to a person with knowledge of the situation who spoke with TheWrap.
Vox Cinemas
This Dubai-based movie theater chain -- not to be confused with media outlet Vox -- often received revenue from rich Saudis who traveled to Dubai on weekends while KSA's cinema ban was in effect. They, along with AMC, got the inside track on negotiations to build cineplexes in the country and are currently the only two chains with the license from the government to do so. Vox declined to comment.
Feld Entertainment
The company told TheWrap it had not signed any deals with the Saudis to bring international events, including "Disney on Ice," "Disney Live," "Marvel Experience" and "Monster Jam" to the kingdom, but that it was "still in conversation" with the kingdom. The company did not wish to comment further.
iPic
In March, the Florida-based luxury movie theater chain had announced it had partnered with Saudi firm BAS Global Investments Co. to develop cinemas and restaurants throughout the kingdom. An iPic rep told TheWrap Wednesday that it had "no further updates" on the deal.
In April, National Geographic announced it was partnering with the General Entertainment Authority of Saudi Arabia to develop and launch several locations for its walk-through virtual-reality zoo.
Reps for Nat Geo told TheWrap they "don't have an answer yet" on whether the partnership will continue.
The iconic live entertainment brand had its first performance in Saudi Arabia on Sept. 23, just before Khashoggi went missing. It is unclear whether the company has any more performances planned in Saudi Arabia. Reps for the company did not respond to a request for comment from TheWrap.
IMG Artists
The performing arts, social media, and festival and events management company signed a letter of intent to bring large-scale festivals to the kingdom.
A rep for IMG told TheWrap that the deal went "stale" shortly after it was signed, following "changes" in the monarchy's 2030 Vision campaign.
Death of dissident journalist Jamal Khashoggi threatens kingdom's modernization plans
WarnerMedia Shuts Down DramaFever Streaming Service
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Here is another video demonstrating the transformational power of hypnosis.
My mom was an artist. Water color, oils, mixed media… realistic work, abstracts, she was massively creative. She created many series of her artwork, including one I particularly love. She called it: "Loving the Spin I'm In." I have several pieces from that series on the walls in my office.
She was right. It's all a spin of our own creation. She chose one that she loved. Me, too.
If you're sick of the negative spin of your thinking and feeling, choose something different. Now. It's so easy…with the tool of hypnosis.
Expand the Boundaries of Your Thinking.
Michael and I made a couple new videos tonight. Here's one. I call this a "magic moment." It illustrates hypnosis without being about hypnosis. 🙂 Wouldn't it be nice to be able to think outside the box. Hypnosis allow you the ability to do just that, and create workable solutions to life's challenges and dilemmas.
Well, Michael and I attended another hypnosis training event this past weekend, because it's always a good idea to learn more and increase skills. It was fantastic! As you may have noticed from my conversations here (and that's what this blog is, me thinking out loud), I CARE about hypnosis. And being good at it. I LOVE hypnosis. I live hypnosis. I want to share the good word on hypnosis. It is so positive and so powerful, so healing, and so mis-understood and underappreciated it the world. (You may enjoy my blog entry on "Hollyweird.") http://mindworkshypnosis.net/hypnotizer/?p=202. People are influenced by movies, TV, popular culture–and those media do not always portray the reality of hypnosis.
So, I have two stories I want to share in this blog entry. 1. My recent efforts to combat "Hollyweird" by giving my professional input into a performance involving hypnosis and 2. More about my hypnosis training and the cool and valuable things I learned there–how to help rewire the brain, specifically for stroke survivors. However, rewiring is also applicable for so much more than that. We also enhanced our knowledge on how to alleviate pain with hypnosis, and "emergency hypnosis" for those life and death situations such as car crashes or dealing with burn victims.
Story 1. I had a fun new gig. I consulted for a theater company. They're putting on a play in the Seattle area and it involves a scene of hypnosis. They wanted to get it right, be authentic, so they contacted me. I was happy to help. I met with the director and several actors and explained the truth about hypnosis, what it is, how it feels, what it can do. They acted out the scene for me and I critiqued. (So much fun!) More than just describing, I also hypnotized them to experience it live and first hand. Because, experiencing is believing. They're believers now. In the positive power and magic of hypnosis. Yay!! Take that, Hollyweird! 🙂 And Hollyweird's continuing saga of evil, thieving, murdering, insane hypnotists with their armies of hypno-zombie slaves.
Story 2. More about the training. It was two days of continuing education, put on by the NGH (National Guild of Hypnotists, which is the oldest, largest and most respected professional organization of hypnotists in the US) and Michael and I both attended. Yay! We now have more tools to help with pain management, emergency hypnosis, and helping stroke survivors. We learned to rewire the brain through hypnosis–which is something we do on a daily basis anyway, but now specifically targeted for helping stroke survivors. After a stroke, there may be a loss of movement, vision, cognitive function, and so on. These tools help stroke survivors to be more functional and regain capabilities! A worthy goal, and wonderful hypnosis tools.
Here's a picture of me and the instructor, Don Mottin. Besides being a stroke survivor himself, He's Vice President of the NGH. That's the national group, and we were darn lucky to have him travel to Seattle to offer this training. It's all in the family as Michael, my Michael, is President of our state's local chapter of the NGH, the NGHWA. http://www.nghwa.org. One of the facets of the guild is to have a committment to continuing hypnosis education. This is some of that! Yes! Learning, in my model of the world, is ongoing and forever. That's what I want and that's what I do. Learn and utilize. My intention, of course, is to be the best and most helpful hypnotist I can be. More tools is good tools.
If you know someone who has suffered a stroke, please do consider hypnosis and hypnotherapy as a tool to help them rewire their brain. I know this works, and I'd be happy to work in conjuction with their medical MDs to enhance the healing process and regain their lives!


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Charity Commission examines 'serious concerns' at Didier Drogba's charity
14 April 2016 by Liam Kay
The regulator says it has opened a case into the former Chelsea footballer's foundation because of issues including low levels of spending
The Charity Commission is looking into "serious regulatory concerns" about a foundation set up by the former Chelsea footballer Didier Drogba.
The regulator said it was looking into concerns about the management and administration of the Didier Drogba Foundation, "significant sums" that had been raised and not been spent, and allegations that donors and the public might have been misled by the charity.
The regulator's initiative comes after an investigation into the charity by the Daily Mail newspaper, which published its findings today.
A statement from Drogba said the Mail's story was "factually incorrect and libellous" and he was beginning legal proceedings against the newspaper.
According to the charity's UK accounts for the year to 30 November 2014, the most recent available on the Charity Commission website, the charity had almost £1.2m in the bank but spent only £14,115 on a hospital project over the course of the year.
But a statement from Drogba, who now plays for the Canadian football team Montreal Impact, said the foundation was set up in the Ivory Coast in 2007 and "retains proof of every single payment made and received".
Drogba said there was "no fraud, no corruption, no mismanagement, no lies, no impropriety" at the charity, and that legal letters and 67 pages of documents had been sent to the Daily Mail before its story was published.
His statement continued: "We have all the documentation required by law both in the UK and the Ivory Coast. The foundation's work to date has been funded entirely by me through sponsorship earnings and donations in the amount of €3.7m.
"The £1.7m from UK fundraising will be used to make the main clinic fully operational, including medical equipment, staff, medicine and running costs.
"Their attempts to destroy the work of the foundation will not deter me and will not stop me continuing the work we have begun."
A commission spokesman told Third Sector that while a case had been opened, no statutory inquiry into the foundation had been launched.
David Holdsworth, chief operating officer at the Charity Commission, said: "The commission has serious regulatory concerns about a number of compliance issues and has contacted the charity to seek an urgent response. In particular, the commission has concerns about the administration of the charity and the oversight provided by trustees, all of whom appear to live abroad, as well as allegations that the charity has provided misleading information to donors and the public.
"Further, the charity has raised and accumulated significant sums of money that have not yet been spent and further information is required about the plans to spend those funds. All these issues merit further investigation by the commission.
"Charities must be accountable and transparent to donors and members of the public who expect charities to operate and abide by the highest standards. Trustees have ultimate responsibility for governing a charity and directing how it is managed and run. All trustees must take these responsibilities seriously in order to ensure that the public can continue to have faith in the vital role charities play in society."
Finance Fundraising Governance Regulation / Regulatory action The Charity Commission Management News International Registered metered content
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While Nintendo has stated that the addition of new content has ended for Splatoon 2, that apparently doesn't preclude the addition of old content. The official Splatoon 2 Tumblr blog has revealed that ten weapons from the original Wii U classic will make their way to the Nintendo Switch sequel.
If you don't see your favorite weapon from the original Splatoon game in that list, chances are that it was already added to the second game as part of the Kensa Collection. It serves as a nice throwback—but what I'm really looking for is the return of older music tracks and special weapons in the first game. But hey, I'm a spoiled Splatoon fan.
Fans presume that these weapons will come in a 4.4.0 update, with one Twitter user capturing that version number for a split-second on the game's title screen. 4.3.0 included the aforementioned Kensa Collection weapons, while the 4.2.0 update contained the final Salmon Run stage and literally a giant rubber stamp weapon.
In other news, Japan is getting a free demo of Splatoon 2 for a week, specifically from March 26 to April 1. There is no word on whether or not that trial will be available to Switch owners in the West. Demo players can also play Salmon Run in the demo and can transfer their progress should they choose to purchase the full game. With a paid service required to play Splatoon 2 online, having such a trial may set a precedent for similar trials from Nintendo in the future.
Back in North America, Nintendo announced their plans for a Splatoon 2 tournament. With qualifying matches in February and March, the Splatoon 2 North America Inkling Open 2019 will culminate in a final event at PAX East.


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Yering Station's Brendan Hawker shows the best of Yarra Valley
"We look to Burgundy as the global benchmark of Chardonnay and Pinot Noir, we are not trying to replicate their wines." Instead Brendan Hawker says he is looking to pin point which blocks and parcels of vines are going to make the right styles of wine that truly reflect the terroir of Australia's Yarra Valley in his role as head winemaker at Yering Station. He also looks at how its winemaking has evolved to become focused on the fruit and bringing together complex blends of its key varieties.
Yering Station's Brendan Hawker explains how a major replanting programme since phylloxera broke out in the Yarra Valley in 2006 has helped the region re-group and potentially make even better, fruit-focused wines.
How did you first get into wine and want to be a winemaker?
I was an avid homebrewer of beer in high school, but I believed that my career path would be in medicine. I didn't get in and after a period of reflection and some external guidance, I realised that I got a lot of satisfaction in making something – in this case beer – that brought others enjoyment. There wasn't a clear 'brewing' pathway through university in Adelaide at the time, but there was a world renowned winemaking program just down the road from where I grew up. So I enrolled and never looked back, despite effectively knowing nothing about wine.
How did you train?
I studied winemaking at Adelaide University and started working at a local bottle shop, which was great exposure to fine wine and tasting.
Where have you been able to do vintages to help with your training and knowledge?
Brendan Hawker has travelled around Australia, New Zealand and California to widen his winemaking experience
My first two vintages were in McLaren Vale at Kangarilla Road, which were a shock to the system and also incredibly fun. I'm forever grateful to the owners and all the winemakers I worked with during this time. All were generous, patient, encouraging and shaped the foundation of the winemaker I am today. Two vintages then followed in Marlborough at Wither Hills, which opened my eyes to new varietals and scale. A harvest in Napa Valley at Jericho Canyon, which taught me what the highest level of detail can look like in winemaking. Last but not least a vintage in Champagne, which showed me the art of blending, not to mention having unfettered access to great French wines.
You are now heading up the winemaking at Yering Station – but you have already spent some time at the winery?
Yes, across a couple of stints. I started at Yering back in the middle of 2008 as a cellar hand and became assistant winemaker in 2009. I resigned in late 2012 to go travelling for a few years with my wife, and was fortunate enough to be brought back on as winemaker in late 2014. I again resigned in late 2018 to take on the winemaking for an old Yarra Valley brand with new owners.
What made you want to return and take on the full winemaking role?
Yering Station is an iconic brand in the Yarra Valley, with fantastic vineyard resources and a legacy of great wine. It is a part of the Rathbone Wine Group, which is family owned and operated and is a quite diverse business in itself, with other iconic regional brands. They are also a lovely family to work for, so when the opportunity presented itself, it was a no brainer to return.
What is your winemaking philosophy and what styles of wine are you looking to make?
I aim to make fresh and bright wines of purity and elegance, with subtle layers of complexity. I believe the way to achieve this is through farming and making each block and parcel of fruit to its own best expression of site, variety and balance. We then focus on careful barrel selection and blending to sew each layer together to finish with a final blend that is expressive of our vineyards, variety and vintage.
Is it fair to say there is a strong Burgundian influence in the wines you make – what is it you are looking to take from Burgundy and reflect in your wine?
Yering Station is going through a major replanting programme following the discovery of phylloxera in the Yarra Valley in late 2006
While we look to Burgundy as the global benchmark of Chardonnay and Pinot Noir, we are not trying to replicate their wines. The influence is more vineyard focused – where Burgundy has centuries of experience in farming vineyards and the understanding of where the better parcels of fruit come from, we look to technology to help us accelerate a better understanding of our blocks and to find the sweet spots within that we harvest separately. In the winery we pick based on flavour and largely aim to keep out of the way of the fruit, avoiding any heavy handed, overly extractive techniques and judicious use of new oak.
What do you see as the key points of difference that wines from the Yarra valley can offer?
Climatically the Yarra Valley is slightly warmer than Burgundy and slightly cooler than Bordeaux, combined with varied topography and soil types enables the Yarra to produce cool climate wines with both precision and focus, and power and intensity, all the while maintaining elegance. It also quite rare for a region to produce fine sparkling wines along side high quality Cabernet blends. All this is possible thanks to our varied meso-climates, thoughtful site selection and talented viticultural and winemaking teams.
Why do you think the UK has been so receptive to the Yering Station wines?
Winning the International Winemaker of the Year' at the highly coveted International Wine and Spirit Competition, London in 2004 brought the Yering Station Winery to prominence in the UK. This combined with our varietal mix and the style of wine we make being fresh, fruit centered, with layers of complexity plus longevity tick a lot of boxes for trade and consumers alike. Having a brand that has a legacy of quality and with the deep history of the property, first vineyard planted in the State of Victoria in 1838, lends much authenticity, which I believe is also critical to any brand's success.
Not to mention decades of hard work and presence by our sales team in the UK market, distributed through Bibendum.
What are you doing in the vineyards and cellar to really accentuate the Yarra and the sense of place at Yering?
Aside from a few small cellar door releases, we make blended wines across our portfolio of varieties. Yet in the vineyard and winery we keep each parcel of fruit separate all the way through its elevage, with many being broken down into smaller sub sections or treatments. This gives us the broadest spectrum possible of wines to begin assembling our blends from. With each label, we then focus achieving a complete, balanced and complex wine, representing what we see as the best of variety, vintage and price point from our little corner of the Yarra Valley.
What have been your biggest achievements to date?
Yearning Station has been scoring high and winning multiple awards for its wines
It has been very satisfying how well our 2020 Reserve Chardonnay and Shiraz Viognier have been received by wine shows and media alike. This is also the case with our 2021 wines, which are in market domestically and beginning to land on shores in the UK.
Looking back a bit further, our 2017 Scarlett Pinot Noir being given 99 points by James Halliday and our 2012 Reserve Chardonnay winning the National Wine Show's Chardonnay trophy were also some fantastic highlights.
What have been the biggest challenges and how have you overcome them?
The discovery of phylloxera in the Yarra Valley in late 2006 has been the biggest challenge by far. We need to assume that eventually all our vineyards will have this vinifera root pest and that all will need replanting on phylloxera resistant rootstocks. So we have been methodically replanting 10 acres per year, give or take. We are approaching a point now where all vacant blocks have been planted and under performing blocks and sites with the wrong variety have been pulled and replanted. This is a great space to be in as by the time we are forced to replant high quality, own rooted vineyards the new plantings will have 10+ years of maturity. Early indications of quality in our replantings are most exciting.
As serious and expensive this challenge is, there is a silver lining in that we are able to restructure our vineyards and varietal mix to better suit market demands, plus safeguard against a warming climate. Focusing more on planting easterly and southerly aspects to Pinot Noir and Chardonnay and using drought resistant rootstocks are a couple of such examples.
What next for you and Yering Station in terms of the wines you are making and where you want to take them?
Yering Station is Victoria's oldest vineyard and a major influence on the Yarra Valley
We are putting a lot of time and effort into refining our processes and detail in what we do in the cellar and vineyards, always looking for improvements. There is a lot of excitement too with new plantings and clones of Chardonnay, Pinot Noir and Shiraz. We have also been growing Grenache and Mourvèdre now for 4 years at our Springlane vineyard, with results pointing towards a bright future for these varieties.
Anything else you would like to add?
We are working hard towards certification of our vineyards and winery by Sustainable Winegrowing Australia. This is a part of our broader and ongoing commitment to sustainability and the continuous improvement of our environmental and sustainable practices.
In the winery we are focusing on our energy usage with the upgrading and better management of our plant and machinery, plus 250kW of commissioned solar generation. Also, reducing our water usage and our choice of cleaning chemistry to have less environmental impact.
In the vineyard we are doing much to improve the quality and biodiversity in our soils using cover crops and composting winery and vineyard organic matter to be spread back out under vine.
You can find out more about Yering Station at its website here.
The Elms Pinot Noir is on sale at £9.99 down from £12.99 in Waitrose until December 27.
Yering Station is distributed in the UK by Bibendum, a partner supplier to The Buyer.
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Cladding cleaning prices are what a lot of tenants enquire about when they are coming to the end of their commercial lease. This is because modern commercial leases tend to have a covenant written in to the lease that restricts the ability for the tenant to carry out any alterations to the premises – whether internal or external.
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This is just one reason why many businesses turn to such restorative cleaning companies. Cladding cleaning prices for restoration are very favourable when compared to hiring a company to replace any altered exterior features. At See Brilliance Ltd, we perform such restoration on cladding and facades at a price that is affordable. Visit https://www.seebrilliance.com to find out more, call us on 01635 230 888 or email info@seebrilliance.com.