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RepresentUs members in North Dakota were a driving force behind anti-corruption Measure 1. They continue to organize to make government work for you and your family, not lobbyists and out-of-state special interests.
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Search For "Real Estate" Companies in DERBY, United Kingdom of Great Britain and Northern Irela - Click Here Now!
LULLINGTON ESTATES LIMITED in DERBY is a company that specializes in Operators Of Nonresidential Buildings. Our records show it was established in United Kingdom of Great Britain and Northern Irela.


For a team to be effective, every member must actively participate in the process of generating business ideas. You must understand that every member of the team plays a key role in coming up with successful business ideas. And when each member is given the opportunity to contribute, they have to put in the required effort for the realization of the group goal. Participation also means that every member will feel as being part of the business idea search process.
The purpose of forming a group to brainstorm business ideas is to finally find a business idea, which when implemented, will lead to greater returns. The goal should be realized by the efficient utilization of the team's resources. When instituting a team to brainstorm business ideas, it doesn't mean that each team member should have the same viewpoint or should agree with everything. It simply means that when the goal is presented, the group or team can converge and get to work as a unit to realize the goal.
Communication is the single most significant tool for achieving any organizational goal. Communication should be effective. Effective communication means every group member feels that, indeed, there is a sense of open communication. Open communication means any problem within the group is handled face-to-face discussion. In other words, there shouldn't be a situation where group members talk behind someone's back. Addressing group issues face-to-face will ensure that respect prevails all the time.
We already know that brainstorming is one of the best ways to come up with business ideas. A great team can harness invaluable information from each other to come up with successful business ideas. With greater interaction, the team can gather ideas from each member, evaluate them, discard the ones that are not feasible and work with a shortlist of the ideas that offer the greatest possibilities for success. If group members can all agree to discuss every business idea fronted by any member and discard the less feasible, then that is a sign of a progressive group. In other words, the group members should agree to disagree before the brainstorming session begins.
A group, typically, has a structural formation and a clear decision-making system that lets it quickly address every situation that comes up. A business idea generation group usually consists of members with different experiences and expertise. The group leader has cultivated the ability to gather group members' opinions and make decisions based on the unanimous agreement of all members. This ability also applies to other decision making aspects of the group, such as resolving conflicts and change to the group's structural formation.
It's for the greater good that all members have or manufacturer these attributes to enable the group comes up with successful business ideas quickly. Implementation of those ideas is the most crucial part of idea generation. Without implementation, the whole process would be pointless.


text:
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redpajama_set_name: RedPajamaCommonCrawl


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text:
31st January 2018 1st November 2019
The Shape of Water (dir. del Toro)
Image: Sally Hawkins as Elisa bonds with the creature © Photo courtesy of Fox Searchlight/ Fox Film Corporation [Source: IMDB]
In this Cold War era top-secret US facility, a lonely, mute janitor (Sally Hawkins) unexpectedly finds compassion and connection with an amphibious creature being held captive. After further curiosity, she forms a unique relationship with the creature.
Director: Guillermo del Toro. Starring: Sally Hawkins, Richard Jenkins, Michael Shannon, Octavia Spencer [15]
Guillermo del Toro has made a knack for himself as a director of bringing his b-movie monster filled fantastical imagination to the adult landscape, The Shape of Water is no different as del Toro returns to form, stitching together this lovingly sweet and twisted romance. What is strikingly prominent above all else in the case of The Shape of Water and del Toro's other work is his authentic genius, a word that sounds clichéd when talking of a director of a certain calibre, however, evidently in The Shape of Water del Toro's detail orientation and particular vision for his film is unmatched in its execution.
More than most other films, you will find yourself noticing the production and stage design, its meticulous and striking character does wonders in the world building of the film. The familiar cinematic landscape of 1960s America is suddenly otherworldly and hauntingly beautiful, aided by the vividly distinct cinematography that feels as warm yet itching as the film's narrative. Which is a wholeheartedly original, moving, appropriately twisted adult fairytale. It's remarkable that del Toro can connect an audience to a relationship between a mute and a fish, but what really drives this home is the astonishing performance from lead Sally Hawkins, it's truly inspiring to see just how much she is able to convey and tell an audience through no words at all.
The rest of the cast members hold up this level of finesse with strong performances of their own, in particular, is Richard Jenkins and his character of the gay neighbour, but what sets this character out above the others is that he is given this eloquent side plot, it's unfortunate that the same level of eloquence was not given to the Michael Shannon's character's side plot. Which bogs down the middle act of the film and distracts from the main narrative, it does however, do a decent job to undo the demonization of the character and add to the theme of the film of having an empty part in your life. Sadly though it subtracts from the overall pacing and plotting of the film and leaves a little to be desired in terms of character development.
Despite this, The Shape of Water is downright breathtaking, from its masterful soundtrack, striking performances and its twisted, sweeping, comedic and charismatic storytelling. It does all it can to remind you of the magical experience that is cinema, painstakingly detailed direction and cinematography highlights the unconditional creativity from Guillermo del Toro, who has truly outdone himself with this outlandish romance that is sure to dazzle.
Posted in Film, ReviewsTagged 2018, Guillermo del Toro, Michael Shannon, Octavia Spencer, Richard Jenkins, Sally HawkinsBy Jake YoungLeave a comment
← Last Flag Flying (dir. Linklater)
Phantom Thread (dir. Thomas-Anderson) →


text:
early and often Nov. 9, 2015
Ben Carson Is Outraged That the Media Is Taking Him Seriously
By Margaret Hartmann
Ben Carson can barely stand to look at the media. Photo: Joe Raedle/2015 Getty Images
A few months ago, Ben Carson was happily comparing things to Nazi Germany, saying appalling things about Muslims, and making wild claims about his near brushes with death. While the other candidates tangled with Donald Trump, the amiable pediatric neurosurgeon was free to focus on turning his moderately successful presidential campaign into a lucrative business venture.
But a funny thing happened on the way to the bestseller list. Several polls showed Carson pulling ahead of Trump nationally, and suddenly the media started asking questions about the incredible tales from Carson's made-for-TV life, such as his claims that he was offered a scholarship to West Point (though he never even applied), protected unidentified white classmates during a riot, and tried to fatally stab a child, only to be thwarted by a belt buckle (and the holy spirit).
This weekend, Carson flipped — or rather, turned things up from low- to medium-energy. At a press conference on Friday night, Carson said Politico told "a bold-faced lie" in its West Point story. Carson implied in his book Gifted Hands that he was formally offered a scholarship, but he clarified on Friday that "It was, you know, an informal 'with a record like yours we could easily get you a scholarship to West Point,'" during a meeting with General William Westmoreland. Politico initially said Carson "fabricated" the tale, then dialed that back.
Carson then blasted the media's behavior in general, noting that they never scrutinized Barack Obama so harshly — then running down a list of various scandals from 2008 that disprove his point. "I do not remember this level of scrutiny for one President Barack Obama when he was running," Carson said. "In fact, I remember just the opposite. I remember people saying, Oh, we won't really talk about that relationship. Frank Marshall Davis? We don't want to talk about that. Bernardine Dohrn, Bill Ayers? He didn't really know him. All the things that Jeremiah Wright was saying. Goes to Occidental College, doesn't do all that well, somehow ends up at Columbia University. Oh, I don't know. His records are sealed. Why are you guys not interested in whether his records are sealed?"
The candidate pushed back on several Sunday shows too, telling Meet the Press that he's being singled out by the "secular progressive movement in this country," because his campaign is attracting "a great diversity of people and it worries them."
He added that the various issues are not "real" scandals, and admitted on This Week that not everything he's written is accurate. "Well, show me somebody, even from your business, the media, who is 100 percent accurate in everything that they say that happened 40 or 50 years ago," he said. "Please show me that person, because I will sit at their knee and I will learn from them."
It's not entirely clear why Carson is complaining — and not because his issues are essentially the same as Hillary Clinton's emails and Marco Rubio's finances. At Friday's press conference, Carson predicted, "All of you guys trying to pile on is going to help me. When I go out to these book signings and meet these thousands of people, they say, 'Don't let the media get you down.'" Turns out there's an upside to all that alleged media persecution:
Is Ben Carson Running for President?
We the People have made 10,000 donations each day this week, raising $3.5M this week alone. Thank you biased media.
— Dr. Ben Carson (@RealBenCarson) November 7, 2015
early and often
Carson Outraged That Media Takes Him Seriously


text:
require 'adwords_api'

def add_keywords_in_bulk()
  # AdwordsApi::Api will read a config file from ENV['HOME']/adwords_api.yml
  # when called without parameters.
  adwords = AdwordsApi::Api.new

  # To enable logging of SOAP requests, set the log_level value to 'DEBUG' in
  # the configuration file or provide your own logger:
  # adwords.logger = Logger.new('adwords_xml.log')

  mutate_job_srv = adwords.service(:MutateJobService, API_VERSION)

  ad_group_id = 'INSERT_AD_GROUP_ID_HERE'.to_i

  # Create AdGroupCriterionOperations to add keywords.
  operations = (1..KEYWORD_NUMBER).map do |index|
    {:xsi_type => 'AdGroupCriterionOperation',
     :operator => 'ADD',
     :operand => {
       :xsi_type => 'BiddableAdGroupCriterion',
       :ad_group_id => ad_group_id,
       :criterion => {
         :xsi_type => 'Keyword',
         :match_type => 'BROAD',
         :text => "mars%d" % index}}}
  end

  # You can specify up to 3 job IDs that must successfully complete before
  # this job can be processed.
  policy = {:prerequisite_job_ids => []}

  # Call mutate to create a new job.
  response = mutate_job_srv.mutate(operations, policy)

  raise StandardError, 'Failed to submit a job; aborting.' unless response

  job_id = response[:id]
  puts "Job ID %d was successfully created." % job_id

  # Creating selector to retrive hob status and wait for it to complete.
  selector = {
      :xsi_type => 'BulkMutateJobSelector',
      :job_ids => [job_id]
  }

  status = nil

  # Poll for job status until it's finished.
  puts 'Retrieving job status...'
  RETRIES_COUNT.times do |retry_attempt|
    job_status_response = mutate_job_srv.get(selector)
    if job_status_response
      status = job_status_response.first[:status]
      case status
        when 'FAILED'
          raise StandardError, "Job failed with reason: '%s'" %
              job_status_response.first[:failure_reason]
        when 'COMPLETED'
          puts "[%d] Job finished with status '%s'" % [retry_attempt, status]
          break
        else
          puts "[%d] Current status is '%s', waiting %d seconds to retry..." %
              [retry_attempt, status, RETRY_INTERVAL]
          sleep(RETRY_INTERVAL)
      end
    else
      raise StandardError, 'Error retrieving job status; aborting.'
    end
  end

  if status == 'COMPLETED'
    # Get the job result. Here we re-use the same selector.
    result_response = mutate_job_srv.get_result(selector)

    if result_response and result_response[:simple_mutate_result]
      results = result_response[:simple_mutate_result][:results]
      if results
        results.each_with_index do |result, index|
          result_message = result.include?(:place_holder) ?
              'FAILED' : 'SUCCEEDED'
          puts "Operation [%d] - %s" % [index, result_message]
        end
      end
      errors = result_response[:simple_mutate_result][:errors]
      if errors
        errors.each do |error|
          puts "Error, reason: '%s', trigger: '%s', field path: '%s'" %
            [error[:reason], error[:trigger], error[:field_path]]
        end
      end
    else
      raise StandardError, 'Error retrieving job results; aborting.'
    end
  else
    puts "Job failed to complete after %d retries." % RETRY_COUNT
  end
end

if __FILE__ == $0
  API_VERSION = :v201209
  RETRY_INTERVAL = 30
  RETRIES_COUNT = 30
  KEYWORD_NUMBER = 100

  begin
    add_keywords_in_bulk()

  # HTTP errors.
  rescue AdsCommon::Errors::HttpError => e
    puts "HTTP Error: %s" % e

  # API errors.
  rescue AdwordsApi::Errors::ApiException => e
    puts "Message: %s" % e.message
    puts 'Errors:'
    e.errors.each_with_index do |error, index|
      puts "\tError [%d]:" % (index + 1)
      error.each do |field, value|
        puts "\t\t%s: %s" % [field, value]
      end
    end
  end
end

redpajama_set_name: RedPajamaGithub


SurviveWith.Us is a fun Minecraft server that you can play on with your friends. Our donation ranks allow you to have maximum fun on the server. Purchases go directly towards the server for hosting costs, development and more.
Any purchases made on this store are under a strict no-refund policy. In an event of attempts to bypass our refund policy via filling a dispute with PayPal and/or your credit card company, your access to the network and possibly anything related will be revoked. Being a donor does not grant you immunity from disciplinary action on the server, and in the event of such, a refund will not be provided to you.
SurviveWith.Us is not in any way affiliated with Minecraft, Mojang AB and/or Microsoft Corporation. Minecraft is © and trademark Mojang AB 2009-2019.


text:
Biografia
Elisabetta Francesca, detta Ella, era figlia dell'arciduca Francesco Salvatore, figlio dell'Arciduca Carlo Salvatore d'Austria e di Maria Immacolata di Borbone-Due Sicilie, e dell'arciduchessa Maria Valeria, figlia minore dell'imperatore Francesco Giuseppe e di Elisabetta di Baviera. La sua madrina di battesimo fu la stessa imperatrice Elisabetta. Dal 1904 frequentò la Scuola scozzese di Vienna. Nel gennaio 1911, Ella prese parte al suo primo ballo di corte.

Matrimonio

Elisabetta Francesca si fidanzò, l'8 aprile 1912, con il conte Georg von Waldburg Zeil e Hohenems (1878-1955), che sposò il 19 settembre 1912 a Niederwallsee. Fu un matrimonio d'amore e non politico. Georg non possedeva soldi o proprietà ed era stato assunto come precettore per i suoi fratelli.

Da questa unione nacquero quattro figli:
 Maria Valeria Waldburg-Zeil (1913-2011);
 Clementina Waldburg-Zeil (1914-1941);
 Elisabetta Waldburg-Zeil (1917-1979);
 Francesco Giuseppe Waldburg-Zeil (1927);

Morte
Elisabetta Francesca morì il 29 gennaio 1930, tre anni dopo la nascita del suo ultimo figlio, all'età di trentotto anni, nel castello Syrgenstein. Suo marito, nel 1931, si risposò con la sorella minore di Elisabetta Francesca, Gertrude.

Ascendenza

Note

Altri progetti

Elisabetta Francesca

redpajama_set_name: RedPajamaWikipedia


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About Us. Mupane Gold Ltd. is an unhedged gold producer and explorer with mining operations and exploration tenements in the Republic of Botswana.


A luxurious home that is sustainable and charming at the same time? It's hard to find but we have it for you folks. Actually, Dallas-based architect Tom Reisenbichler got it for you.
The Caruth Boulevard Residence is located in Dallas, Texas to be more exact. It's a LEED Gold contemporary home that promises to spoil you while being easy on the environment. Well hidden behind a beautiful scenery, the whole space is about clean and modern lines and an entertaining lifestyle where the indoors blend with the outdoors in a highly fashionable way.
Striking features like the wooden walls in the kitchen or the relaxing area and the wooden ceiling on the outside, certainly kick it up a notch, but it's the warm atmosphere of the living room and all other spaces that gets to me for the Caruth Boulevard Residence.
And because we mentioned the green aspect of the home, you should know that — according to its designer — the house features many sustainable strategies, from photovoltaic solar panels and recycled materials to native plants that are drought tolerant.
A great example of how you should care about every detail of sustainability and a bohemian lifestyle, at the same time. Don't you think?


From England, I've been in the wargaming Hobby for 20(ish) years now, mostly sticking with warhammer fantasy of varying editions for the most part.
Soft spot for Chaos Warriors (warriors of the Dark Gods) and Dark Elves (Dread Elves).
Now I'm in the Rules Clarity Team!


You can buy the book at Quaker Books. Just click the image.
A companion for staying spiritually grounded and open to divine wisdom as we shape our lives.
When it comes time to make important decisions in our lives, it is very human to want to feel that the decisions we are making are good.
When we approach decision making as a spiritual practice, we are recognizing that we need the aid of the wise and loving Spirit whose Light exceeds our own.
With gentle encouragement, Bieber shows us how to weave these themes together so that they strengthen our decision making process and help us find our path.
Each chapter is enriched by detailed and practical spiritual exercises, which serve as tools for our process of decision making. An appendix includes a guide for using this book in groups, with reading assignments, practices and meditations for each session.
Compelling, beneficial…. Filled with insight and wisdom, as well as practical practices in discernment, this is a volume you'll return to often.
Decision Making and Spiritual Discernment was released in October 2010 to critical acclaim. Your review at Amazon.com and other sites is welcomed and helps to let others know about this unique resource. Click here to purchase the book from preferred vendor, Quaker Books, or order through your favorite bookseller.
Click the image to buy Nancy's book from Quaker Books.
(c) Nancy Bieber 2010-2019. Site by JubileeArts.


text:
Blanca Judith Díaz Delgado (born 22 February 1958) is a Mexican politician affiliated with the PAN. As of 2013 she served as Senator of the LX and LXI Legislatures of the Mexican Congress representing Nuevo León. She also served as Deputy during the LIX Legislature, as well as the Congress of Nuevo León.

References

1958 births
Living people
Politicians from Mexico City
Members of the Senate of the Republic (Mexico)
Members of the Chamber of Deputies (Mexico)
National Action Party (Mexico) politicians
Women members of the Chamber of Deputies (Mexico)
Women members of the Senate of the Republic (Mexico)
Autonomous University of Nuevo León alumni
Members of the Congress of Nuevo León
20th-century Mexican politicians
20th-century Mexican women politicians
21st-century Mexican politicians
21st-century Mexican women politicians


text:
Q: Why does return True have to be outside the if statement and the for loop? I'm trying to see if lst2 is the reverse of lst1.
For the following code, why does return True have to be outside the if statement. When I put else: return False with the if statement, both of the prints return True (which is incorrect). Thank you!
def reversed_list(lst1, lst2):
  for index1 in range(len(lst1)):
    if lst1[index1] != lst2[(-1 - index1)]:
      return False
  return True

print(reversed_list([1, 2, 3], [3, 2, 1]))
print(reversed_list([1, 5, 3], [3, 2, 1]))

A: If you put it into the if, i.e. into the same conditionality as the return False, but after it, then it will never be executed, because the function will always have been left with the first return. Or it will always be executed inside the if, before, leaving it and thereby unintendedly overriding the intended False. This seems is what you are observing.
If you put it into the loop (but outside the if) it will be executed during the first iteration of the loop, i.e. much too early.
If you put it into the loop, but with an else, it will still be executed too early. at the first case of not False. This is still not what you want, because you only want a True when there is no False anywhere in the loop, not already at the first case of not False.
You only want to return a true boolean if the loop gets completly through without ever triggering the False. You want that because otherwise you might miss cases of False.
This is why the position you describe and use in the shown code, outside of both, the if and the loop, is the only correct way.

A: This approach is a lighter method to a brute force approach.
With brute force, the second list is reversed and then all the elements of both lists are compared. That's a lot of wasted resources, especially if the lists are massive in length.
The approach provided in your Q utilizes a pointer, which essentially allows you to "stop early." Instead of sorting the second list, iterate over the elements and compare them. If they match, move on to the next elements. If they do not match, escape early and return False. With this approach, you cannot return True until all the elements in the lists are compared. (Hence, return True is outside the for loop.)

A: The return statement immediately stops the execution of a function or method.
In this way, your function stops at the first difference and returns  False. If all tested elements are equal, then the loop finishes without that return False statement and continues with the next statement which is  return True .

A: I am not sure if this is exactly what you need, but this is a way of checking if l1 is the same as l2 reversed.
l1 = [1, 2, 3]
l2 = [3, 2, 1]
l2.reverse()

if l1 == l2:
    print("Yes")
else:
    print("No")

redpajama_set_name: RedPajamaStackExchange


Very large home across the street from 27-hole golf course. Other than the 3 bedrooms there is also a sleeping loft and a huge basement which is a multi purpose room with a bar, game room and additional sleeping quarters. Home has new carpet and some new windows but is somewhat dated and ideal for a fixer upper. In addition, it also has 2 driveways, allowing for extra parking. Location is excellent. Situated on a paved road only 5 minutes from shopping, restaurants, three fishing lakes, rec center, churches and hospital. Last but not least are the beautiful views off covered back decks.


We started HowToEngineering.com August 2015 to show our projects and how we made them. Then in August 2016 we decided to expand our business and start to sell things. Some things we make, other things people give us to sell.
We want to use this new Blog to explain our business story, our experiences, what we learn, how we started, etc.
We will be writing posts showing the business side of the company, and behind the scenes details of our company.


Global beauty brand Benefit came to us in 2014 with the challenge to improve their ROI and CPA figures through PPC in the UK. Benefit also wanted to utilise their data to make smarter business decisions.
Benefit's return on investment has seen significant increases since we started working together.


text:
package com.jamerlan.commands.impl.in;

import com.jamerlan.ServerState;
import com.jamerlan.commands.Command;
import com.jamerlan.model.Battle;
import com.jamerlan.utils.CommandParser;

import java.io.IOException;
import java.io.PrintWriter;
import java.util.HashSet;

/**
 * BATTLEOPENED battleID type natType founder ip port maxPlayers passworded rank mapHash {engineName} {engineVersion} {map} {title} {gameName}
 *
 * BATTLEOPENED 20535 0 0 EvoRTSDedicated4 54.183.228.213 8254 8 0 0 540337253 Archers Battlefield - v05	Evolution RTS Dedicated Host 4	Evolution RTS - v10.17
 */
public class BattleOpened implements Command<String> {

    private ServerState serverState;

    public BattleOpened(ServerState serverState) {

        this.serverState = serverState;
    }

    @Override
    public void execute(String line) throws IOException {
        CommandParser parser = new CommandParser(line);
        String commandName = parser.getString(" ");

        int battleId = parser.getInt(" ");
        int type = parser.getInt(" ");
        int natType = parser.getInt(" ");
        String founder = parser.getString(" ");
        String ip = parser.getString(" ");
        int port = parser.getInt(" ");
        int maxPlayers = parser.getInt(" ");
        int passworded = parser.getInt(" ");
        int rank = parser.getInt(" ");
        int mapHash = parser.getInt(" ");
        String mapName = parser.getString("\t");
        String title = parser.getString("\t");
        String gameName = parser.getString();

        serverState.getBattles().stream().filter((Battle b) -> b.getBattleId() == battleId).findAny().ifPresent((Battle battle) -> {
            battle.setType(type);
            battle.setNatType(natType);
            battle.setFouder(founder);
            battle.setIp(ip);
            battle.setPort(port);
            battle.setMaxPlayers(maxPlayers);
            battle.setPassworded(passworded);
            battle.setRank(rank);
            battle.setMapHash(mapHash);
            battle.setMapName(mapName);
            battle.setTitle(title);
            battle.setGameName(gameName);

            battle.setUsers(new HashSet<>());
        });
    }
}


Hawai'i Island's shores are alive with wildlife. Some of these animals, like humpback whales, Hawaiian monk seals and sea turtles, are considered ENDANGERED SPECIES and are protected by federal laws. Dolphins and other whales, though not endangered, are protected by the MARINE MAMMAL PROTECTION ACT.
Hawai'i's marine mammals are fascinating and easily observed creatures, which are the main reasons why nature-based tourism is a popular segment of the visitor market. Scores of tour boat companies and water-based activities on Hawai'i Island cater to whale and dolphin watching.
1. Stay at least 100 yards from humpback whales and 50 yards from dolphins, monk seals and sea turtles.
2. It is against the law to approach, chase, surround, touch or swim with marine mammals, including dolphins.
3. If approached by a marine mammal or turtle while on a boat, put the engine in neutral and allow the animal to pass.
4. Do not harass, swim with, hunt, capture or kill any marine mammal.
5. Feeding marine mammals is prohibited under federal law.
6. To report suspected violations, call the NOAA Enforcement Hotline at (800) 853-1964.
Local author and proprietor Robert Wintner, also known as SNORKEL BOB, has several books available that dive deeper into the topic of Hawai'i's protected reefs and the marine animals that call them home. Every Fish Tells a Story records the tales of fish and their underwater communities through stunning photos taken by Snorkel Bob himself, while the tome Neptune Speaks and the novel Flame Angels both underscore the values of wilderness and the need to protect our natural resources.
All books are available at Snorkel Bob's outfitters on all islands, and 100 percent of proceeds from book sales accrue to the campaign to stop the aquarium trade.


The Hertz Rent a Car at Denver International Airport has 1,300 rental vehicles requiring cleaning and fueling every day.
That's why, when the business's fueling systems needed an upgrade due to the age and reliability of the existing equipment, Hertz Senior Program Manager of Fuel Systems and Compliance Drew Lazazzera turned to a company he knew he could count on.
CGRS has provided environmental and compliance services to Hertz in the past as well as installed an aboveground storage tank for the company in downtown Denver a couple of years ago. Lazazzera said it was "the ease of working with (CGRS personnel)" that convinced him to hire CGRS again.
To complete the mission, CGRS divided the work into two phases, performing all of the work – including pouring concrete, scheduling inspections and starting up the system – on two of the five tanks before beginning the same work on the remaining three tanks. The CGRS team began the original project in late September and completed it in mid-December. They returned after the holidays to perform change-order work at the customer's request, which they completed in two days.
From the permitting stage to the post-completion change order, the CGRS team impressed Lazazzera with their professionalism, knowledge, go-to attitude and quality of work.
"Of course there were some 'hiccups,' but that is to be expected of any project of this magnitude," Lazazzera said. "But it was how CGRS responded to these issues that sets you apart from the 'normal contractors' in our industry. I am very pleased with the final product that I got to inspect (recently).
Contact CGRS at 800.288.2657 to learn how we can help upgrade your fueling system!


text:
Options for Improving the Safety of Superannuation - Report of the Superannuation Working Group
10. Financial Assistance to Failed Superannuation Funds
The Government invites comments on the circumstances under which Part 23 could be broadened, and how any compensation should be funded, including whether funding of broader compensation arrangements by industry levies would be supported.
The Issues Paper indicated that Part 23 could be broadened to include misleading or deceptive conduct as grounds for a claim for financial assistance.
Views from the consultation process
There was very little support for the broadening of Part 23 of the SIS Act to include financial assistance for acts that are misleading or deceptive. Many submissions indicated that Part 23 had not yet been tested, and that changing existing provisions before it could be determined whether they were operating effectively was not in the best interests of the industry.
Submissions were concerned that a broadening of Part 23 would increase the burden on effectively managed, low-risk funds to provide compensation for poorly managed, high-risk funds. Submissions also suggested that widening Part 23 would lead funds to reduce their own levels of protection, resulting in increased moral hazard, which was not considered appropriate. The Securities Institute of Australia stated that it 'does not support any broadening of such assistance at this stage, due to the inherent moral hazard involved and to the difficulty in defining what sorts of losses would be protected, given the absence of explicit promises'.
Further, most submissions were not supportive of a levy system to provide compensation, preferring that it be provided by some form of insurance or consolidated revenue. AMP indicated that '[a]n industry assistance fund could in the longer term act as a disincentive for prudent risk management with the cost of failure being borne by prudent trustees and their members.'
ASFA supported reworking Part 23 to ensure a more timely and efficient application of the current provisions, and expressed support for the capping of restitution and the implementation of a more formal definition within Part 23 of 'substantial diminution'.
A participant at the focus group sessions expressed concern about the current processing of applications under Part 23, and queried the benefits of deferring legislative change given these delays.
Consideration of the proposal
Part 23 of the SIS Act provides a framework for providing financial assistance to regulated superannuation funds (other than SMSFs) that suffer an 'eligible loss' (defined in the SIS Act) as a result of fraudulent conduct or theft, subject to certain conditions. For an accumulation fund, the loss must have caused substantial diminution of the fund leading to difficulties in the payment of benefits. For a defined benefit fund, the eligible loss is so much of a loss that a standard employer-sponsor is required to pay to the fund, but would be unable to do so without becoming insolvent. Further, the Minister must determine that the public interest requires that a grant of financial assistance be made.
There does not need to be a conviction for fraudulent conduct or theft; rather, it is for the Minister making the determination to be convinced in his or her mind that fraudulent conduct or theft did occur.
If the Minister determines to grant financial assistance, he or she must also determine whether the assistance is to be paid out of:
the Consolidated Revenue Fund; or
the Superannuation Protection Reserve funded through a levy on certain superannuation funds.
The Issues Paper invited comment on the circumstances under which Part 23 could be broadened, and how any compensation might be funded.
This proposal was aimed at addressing concerns that the provisions of Part 23 may not be sufficiently broad to meet community expectations about financial assistance to failed superannuation funds. However, the SWG acknowledges that, in light of existing Government policy that financial assistance be funded by industry levies, any expansion in the test could increase the burden on well-run superannuation funds.
As with other financial investments, the Government does not explicitly guarantee superannuation savings. However, given the special characteristics of superannuation - compulsion, preservation rules, limited choice and portability - as well as its role in retirement income policy, the SIS Act does provide protection for superannuation fund members that suffer loss as a result of fraudulent conduct or theft.
Such a safety net was supported by the FSI, although the FSI suggested certain limits on the provision of financial assistance:
'Where losses as a result of serious fraud are incurred by beneficiaries of superannuation funds (other than excluded funds), the Treasurer should have powers, on the advice of the [APRA] to levy superannuation providers at a rate not exceeding 0.05 per cent of assets where such restitution is considered to be in the national interest. Restitution should be limited to 80 per cent of the original entitlement of beneficiaries as determined by [APRA] ...'13
While the Government accepted this recommendation, no changes to Part 23 have been made to give effect to it.
The Senate Select Committee on Superannuation and Financial Services has highlighted the amount of time required to assess applications under Part 23, and recommended that the Government look at ways to expedite the process.14 Industry submissions also flagged concern that the decision-making process under Part 23 is too slow.
As noted above, prior to making a grant of financial assistance, the SIS Act requires that certain tests be met. The legislation provides the Minister with discretion to determine whether these tests have been met.
To assess whether there has been a loss suffered by a fund as a result of fraudulent conduct or theft, that has caused a substantial diminution of the fund leading to difficulties in the payment of benefits, requires a thorough assessment of the circumstances of the loss. Ascertaining these details is not simple, and recovery action or investigations can take some time. This reflects the general complexity of events surrounding fund failures.
A decision on a grant of financial assistance that is made prior to gaining and assessing all of the facts could be challenged on administrative or judicial grounds. The likelihood of challenge on these grounds may increase where a grant is funded by levies on other superannuation funds.
Further, while a number of applications are currently being considered under Part 23, no decisions have yet been made. Thus, the provisions of Part 23 have not been fully tested in practice.
Given that the effectiveness of the current provisions has not been fully tested, and the lack of industry support for any change, it seems inappropriate to recommend changes to Part 23 at this time. Further, any legislative changes arising from a review by the Government of the provisions after a Part 23 determination has been made could not have retrospective effect, and thus would not provide relief for current applications pending determination.
Recommendation 27
Given that the current provisions contained in Part 23 of the SIS Act have not yet been fully tested, the SWG recommends that the provisions not be changed at this time. However, the SWG recommends that the Government review the operation of Part 23 and consider possible amendments to it, in consultation with relevant stakeholders, once the first decision under Part 23 has been made.
13 Financial System Inquiry 1997, Recommendation 55.
14 Senate Select Committee on Superannuation and Financial Services 2001a, Recommendation 6.
Preliminaries, Index and Abbreviations
2. Universal Licensing Regime
3. Risk Management Plans
4. Prudential Standards - Making Power
5. Longer Term Options - Separation of Prudential and Retirement Income Provisions
6. Prudential Standards
7. Annual Meetings
8. Public Disclosure of Annual Returns
9. Member Approval for Giving Benefits to Related Parties
11. Other Issues


Carbon fibre components designed and manufactured by Exel Composites have completed nine years of service in a high precision application at CERN's Large Hadron Collider (LHC) particle accelerator in Geneva.
As a key part of the particle tracker support structures for the LHC's Compact Muon Solenoid (CMS) detector, Exel's pultruded profiles had to satisfy strict dimensional tolerances and sustain the highest level of performance in this challenging environment, where any downtime or failure would impact major scientific experiments.
The LHC is the world's largest and most powerful particle accelerator. It consists of a 27 km ring of superconducting magnets with a number of accelerating structures to boost the energy of the particles along the way. Inside the accelerator, two high-energy proton beams travel at close to the speed of light, in opposite directions, before they are made to collide at four locations around its ring. The CMS detector sits at one of the four collision points and records the paths taken by particles using a silicon tracker consisting of around 75 million individual electronic sensor channels arranged in 12 concentric layers. The tracker needs to record particle paths with very high precision yet be lightweight so as to disturb the particles as little as possible.
The Exel components are part of the 688 high-precision structures supporting the silicon tracker modules. These are made up of two 1.2 m long carbon fibre epoxy composite U-profiles of 0.7 mm wall thickness and L-shaped cross-bars to form a frame structure on which the particle detecting modules sit. In addition to delivering the lightweight and radiation transparency required for this application, it was critical that the Exel profiles met extremely tight tolerances in terms of dimensions and straightness and maintained all mechanical properties at the low temperatures encountered in the CMS. In order to provide the high levels of stiffness and thermal stability required the company designed the profiles using high modulus unidirectional (UD) carbon fibre. A thin glass fibre surface tissue was also employed to facilitate processing. All of the components and fixtures were then assembled and bonded on jigs at the Helsinki Institute of Physics to create structures with a dimensional tolerance of ± 0.05 mm.
Exel's capabilities in the production of high performance thin-walled pultruded profiles and the company's experience in designing with high modulus carbon fibres are said to be key success factors in this project. Exel has also collaborated with CERN before, supplying around 200 km of electrically insulating glass fibre profiles to frame the superconductive busbars of the LHC.
Exel delivered the tracker support profiles to CERN from 2001 to 2005, with the final operational use starting in 2008. The CMS detector has been performing excellently, culminating in 2012 with the discovery of a new elementary particle, the Higgs boson.


Below you will find various stories from residents of St. Anne's Place.
Mr. D was a 75 year old gentleman who had returned to Toronto in the late summer of 2002 after living a number of years in British Columbia. It was recommended that he move away from the west coast climate in order to help him with his increasing pain resulting from severe arthritis. Mr. D packed up whatever he could in his car and made the long trip to Toronto. Upon arriving in the city, he found that it was impossible to find adequate, safe and affordable housing and spent 3 months living in his car, while looking for housing. Mr. D was referred to St. Anne's Place through a community agency. He was extremely frightened at the thought of having to spend the winter months living in his car and very desperate to secure housing. At. St. Anne's he was able to secure a large studio apartment, with the main meal of the day provided, at an affordable rate. Mr. D was extremely thankful that he had found St. Anne's and was able to move out of his car the very next day.
Ms. H is an 81 year old Portugese woman who was referred to St. Anne's through a cross-cultural agency in Peel Region. Ms. H was living in an abusive situation in which she had no control over her finances, was denied the ability to visit with other family members, was isolated from any outside contacts and had to share a bedroom with three teenage grandchildren. Ms. H was desperate to leave her living situation, but feared that she would have no place to go. Through numerous contacts with the social worker and a visit from Ms. H's son who lives in Portugal, St. Anne's was able to offer Ms. H her own apartment. On the day that Ms. H left her abusive living situation, there was no one home to say goodbye. However, when she arrived at St. Anne's, she was met by a group of family members who she had not seen in over two years. When Ms. H was handed the key to her own apartment at St. Anne's, she wept openly. Today Ms. H spends her days visiting with other family members, or enjoying the company of the other Portugese tenants that live at St. Anne's. She joins in activities and no longer feels the loneliness and isolation that she once felt.
Mr. F is a 73 year old gentlemen who was referred to St. Anne's from the Centre for Addiction and Mental Health. Mr. F had been an inpatient at the hospital for the past year, and the staff at the hospital all agreed that Mr. F did not need to be in hospital, but were uncertain of where he could be housed that would offer not only affordability, but the necessary supports that Mr. F required. On two different occasions and at two different long-term care facilities, Mr. F was escorted from the premises after only two weeks due to such disruptive behaviour. Applications made to other long-term care facilities were refused as they felt that they did not have the resources to provide the type of support that Mr. F required. St. Anne's Place felt that we may be taking a chance, but offered Mr. F a one-bedroom apartment, with supportive housing services. Mr. F moved into St. Anne's on January 15, 2003 and is still with us – this is the longest period of time that Mr. F has been supported in the community, away from the hospital! At a meeting with hospital staff, they commented that the placement for Mr. F has been a "tremendous success" and praised the St. Anne's program for their ability to provide a caring and stable home environment.
Make Your Donation and Help Others Now!


text:
When Is The Next Solar Eclipse? 2017's Is The First Over The U.S. In A Long While
By Brandi Neal
SONNY TUMBELAKA/AFP/Getty Images
People are making a pretty big deal about the Aug. 21 total solar eclipse, and for good reason. This celestial event is the first visible in the U.S. since 1979, and the first accessible to most Americans since 1918. If you're wondering: When is the next solar eclipse? you're not alone. If this one lives up to the hype everyone's going to want to see more. While solar eclipses are fairly common, there are several types of solar eclipses, which are visible in different areas of the world at various times throughout the year.
A total solar eclipse, like the kind you'll see Aug. 21, occurs when "the new moon comes between the Sun and Earth and casts the darkest part of its shadow, the umbra, on Earth. A full solar eclipse, known as totality, is almost as dark as night," according to the website Time and Date.
Total solar eclipses typically occur once a year, and are visible in different parts of the world each time. On rare occasions up to five solar eclipses can occur in one year. According to Time and Date, the last time this happened was in 1935, and the next time will be in 2206. Unless you contract an ancient blood virus, like Lady Gaga's the Countess on American Horror Story: Hotel, I don't think anyone alive today will be around witness it. But, never say never.
Partial solar eclipses occur when the moon comes between the Sun and Earth, but the moon only partially covers the Sun's disk, Time and Date noted. Many people in the U.S. who are not in the path of totality will experience a partial solar eclipse Aug. 21.
NASA/Getty Images News/Getty Images
The third type of eclipse is an annular solar eclipse. This type of eclipse happens "when the moon covers the Sun's center, leaving the Sun's visible outer edges to form a 'ring of fire' or annulus around the moon." Perhaps this is what Johnny Cash was singing about in "Ring of Fire."
Hybrid eclipses are the last type of solar eclipse. These can look like either an annular solar eclipse or a total solar eclipse, depending on where you're located along the central eclipse path, according to Time and Date.
"During a hybrid solar eclipse, the Earth's curvature brings some sections of the eclipse path into the Moon's umbra, the darkest part of its shadow that creates total solar eclipses, while other areas remain outside the umbra's reach, causing an annular eclipse."
When Is The Next Solar Eclipse In The U.S.?
Your next opportunity to view a total solar eclipse in the U.S. is April 8, 2024 when one will be visible from Texas to Maine. If you're in Alaska, you will also have a chance to see a total solar eclipse March 30, 2033. A few northern states will be in the path of a total solar eclipse Aug. 3, 2044, a large swath of the U.S. will be able to view a solar eclipse Aug. 12, 2045, and a few southern states will be able to witness a solar eclipse March 30, 2052, according to information Time magazine obtained from NASA.
Is the "ring of fire" annular solar eclipse your jam? You can view the next one in the U.S. on Oct. 14, 2023, according to retired NASA astrophysicist Fred Espenak on his website Mr. Eclipse.
If you manage to get some good snaps of the Aug. 21 solar eclipse, use NASA's Flickr Gallery to share your photos, but if you prefer to leave the photography to the pros, you can follow these Instagram accounts for non-stop eclipse coverage. Most importantly, don't forget to make sure you have NASA-approved eclipse glasses. Yes, this eclipse is a big deal, because this many people in the U.S. won't have access to another one like it for 28 years.


You can have the kind of head-turning hair that's the talk of the town with professional hairstyling from Dita Salon.
Dita Salon is a full service unisex hair salon in Etobicoke that creates fabulous looks at affordable prices. Our talented hairstylists are experienced in using the latest hairstyling techniques to leave your hair looking modern, glossy and fabulous.
Revamp your style with vibrant colour, hair extensions, or a fresh cut.
Women and men across the GTA come to Dita Salon for all their hair necessities because they know that we deliver stunning results. From cuts, washes and blow outs to classic updos for a special occasion, we'll make sure you leave our salon with remarkable hair and undeniable confidence.
With regular trims and treatments, your hair will be healthier, more lustrous and stronger. Be ready for any event with haircare services from Dita Salon. Call today to book an appointment.


Recommended Name: � the Later Minchiate pattern.
This pattern was originally classified as IPT-1.1.
In the second quarter of the 18th century, an as yet unidentified Florentine maker introduced this pattern as a new classicised version of the Minchiate pack, in keeping with contemporary taste. Save that the short tunics of the Kings of Swords and Batons were replaced by long robes, the iconography of the traditional pattern, IPT-1, was retained, as were many of the details of the numeral cards in the suits; but the detailed designs of the trumps and court cards were for the most part completely altered. Three 18th-century packs of this type, of varying degrees of incompleteness, are in the Lady Charlotte Schreiber Collection in the British Museum.
It does not appear that the new pattern made much headway in competition with its older rival, but in about 1850 it was revived, or possibly simply continued, in a revised form by Chiari of Florence. The 19th-century version is somewhat less elaborate than the 18th-century one: It follows it closely or exactly on most of the cards, but diverges from it on about a quarter of the trumps and court cards. This version was also produced by Baragioli of Florence in c.1880. It did not supersede the earlier pattern which continued to be made in Florence until the 1890s, and probably remained more popular there than IPT-1.1 as long as the game of Minchiate continued to be played; but it was adopted by Solesio of Genoa (late 19th to early 20th century), who continued to produce it until the 1930s, and it was therefore the pattern used for the last Minchiate cards to be produced, surviving its rival by about three decades.
The composition is exactly the same as that of the traditional Minchiate packs. There are 97 cards, comprising 56 suit cards, 40 trumps and the Matto. The top five trumps are unnumbered, and the remainder numbered from I to XXXV. The Swords are straight but intersecting. In Swords and Batons the so-called Cavalli are centaurs, in Cups and Coins they are other half-human, half-animal monsters, and, in the latter two suits, the lowest court cards are Maids (Fantine), though in Swords and Batons they are Jacks (Fanti).
All presently known makers are mentioned under History.
Cards made by Solesio of Genoa.


text:
Al-Zarqawi Killed: Notes
NEXT:Al-Zarqawi Killed: ABC's Raddatz Had Just Closed Her Eyes When A Source Called...
PREVIOUS:The Fundamental Cable News Question
TV Biz
By Brian on Jun. 8, 2006 - 1:45 PM
> Richard Engel blogs about how the news broke: "We got a phone call this morning that we had to come to an important press conference by the Iraqi prime minister here in the Green Zone. We were given no details, but we were told that it was important that we should come…"
> Brian Williams anchored an hour on MSNBC at noon…
> "ABC News Radio was the first radio news operation to report the breaking news story to its listeners and affiliates (about 2 minutes after network TV at around 2:40 am ET)," the net notes. "The breaking news coverage of al-Zarqawi's death is another example of the extremely well-coordinated effort between the ABC News and ABC News Radio operations…"
> An e-mailer says: "I heard the Al-Zarkawi news was on ABC Radio News at the Midnight PT (3am ET) report, but I hesitated in believing it because I couldn't find the news ANYWHERE else… including ABCNews.com! When I gave up to go to sleep at about 12:15, their website still didn't have the news posted. Kudos to breaking the story, but ABCNews.com was asleep like everybody else."
> Chris Wallaceon FNC: "This is the baddest man in the world; we shouldn't forget that…"
> Wizbang live-blogged CNN's coverage with a skeptical eye (via ICN)…
> "Dan Senor was on Fox today and he was amazing. A great person to have on the air right now during the al-Zarqawi story," an e-mailer says…


For whatever reason, I have tended to circle this week's stamp set, Beautiful You. Now that the time has come to really use it I'm wondering why I hesitated as the ideas are flowing freely.
This stamp set comes in two cases but for my own sanity, what I try to do in these instances, is double them up in the one case. That way when I grab the stamp set, I know I have it all.
If I haven't mentioned this yet, now is a really good time to stock up on any of the retiring 2016-2018 In-Colours. In particular, if you have the ink pads please ensure you have plenty of re-inkers for each color!


text:
The brain mineralocorticoid receptor: greedy for ligand, mysterious in function
J M Reul, A Gesing, S Droste, I S Stec, A Weber, C Bachmann, A Bilang-Bleuel, F Holsboer, A C Linthorst
Neurobiology of Stress and Behaviour Research Group
Neuro-Epigenetics of Stress and Cognition Research Group
Glucocorticoids exert their regulatory effects on the hypothalamic-pituitary-adrenocortical axis via two types of corticosteroid receptors: the glucocorticoid receptor and the mineralocorticoid receptor. Whereas the glucocorticoid receptor has a broad distribution in the brain, highest levels of mineralocorticoid receptor are found in the hippocampus. Based on the differential occupancy profile by endogenous glucocorticoids, glucocorticoid receptors are thought to mediate negative feedback signals of elevated glucocorticoid levels, whereas mineralocorticoid receptors control the inhibitory tone of the hippocampus on hypothalamic-pituitary-adrenocortical axis activity. Dysfunction of mineralocorticoid receptors and glucocorticoid receptors are thought to be implicated in stress-related psychiatric diseases such as major depression. Because of its intriguing features, we focus in this review on the mineralocorticoid receptor and provide data which reveal novel aspects of the pharmacology and physiology of mineralocorticoid receptors. Newly obtained results are presented, which help to solve the paradox of why dexamethasone binds with high affinity to mineralocorticoid receptors in vitro, yet binds poorly in vivo. Until recently, mineralocorticoid receptor protein and mRNA levels could only be routinely studied with in vitro cytosol binding assays, in vitro and in vivo receptor autoradiography, Northern blot analysis, and in situ hybridization. These methods are unfortunately hampered by several flaws, such as the necessity of adrenalectomy, no or poor neuroanatomical resolution, the fact that mRNA does not provide the same information as protein, or combinations of these factors. We present immunohistochemical data on mineralocorticoid receptors in the brain obtained by using commercially available antibodies, which alleviate many of these shortcomings. Furthermore, an in vivo microdialysis method is presented which allows the assessment of free corticosterone levels in the brain, which is critical for the study of the pharmacological basis of mineralocorticoid receptor (and glucocorticoid receptor) function. Finally, a novel aspect of the regulation of mineralocorticoid receptors is described which provides evidence that this receptor system is dynamically regulated. In conjunction with previously reported effects of antidepressants, these results have initiated a new concept on the cause of the hypothalamic-pituitary-adrenocortical axis disturbances often seen in stress-related psychiatric disorders such as major depression.
European Journal of Pharmacology: Molecular Pharmacology
Brain Chemistry
Receptors, Mineralocorticoid
Fingerprint Dive into the research topics of 'The brain mineralocorticoid receptor: greedy for ligand, mysterious in function'. Together they form a unique fingerprint.
Mineralocorticoid Receptors Medicine & Life Sciences
Ligands Medicine & Life Sciences
Hippocampus Medicine & Life Sciences
Psychiatry Medicine & Life Sciences
Pharmacology Medicine & Life Sciences
Reul, J. M., Gesing, A., Droste, S., Stec, I. S., Weber, A., Bachmann, C., Bilang-Bleuel, A., Holsboer, F., & Linthorst, A. C. (2000). The brain mineralocorticoid receptor: greedy for ligand, mysterious in function. European Journal of Pharmacology: Molecular Pharmacology, 405(1-3), 235-49.
Reul, J M ; Gesing, A ; Droste, S ; Stec, I S ; Weber, A ; Bachmann, C ; Bilang-Bleuel, A ; Holsboer, F ; Linthorst, A C. / The brain mineralocorticoid receptor : greedy for ligand, mysterious in function. In: European Journal of Pharmacology: Molecular Pharmacology. 2000 ; Vol. 405, No. 1-3. pp. 235-49.
@article{1d3c1614cbaa4b86a42efd6a4a05de75,
title = "The brain mineralocorticoid receptor: greedy for ligand, mysterious in function",
abstract = "Glucocorticoids exert their regulatory effects on the hypothalamic-pituitary-adrenocortical axis via two types of corticosteroid receptors: the glucocorticoid receptor and the mineralocorticoid receptor. Whereas the glucocorticoid receptor has a broad distribution in the brain, highest levels of mineralocorticoid receptor are found in the hippocampus. Based on the differential occupancy profile by endogenous glucocorticoids, glucocorticoid receptors are thought to mediate negative feedback signals of elevated glucocorticoid levels, whereas mineralocorticoid receptors control the inhibitory tone of the hippocampus on hypothalamic-pituitary-adrenocortical axis activity. Dysfunction of mineralocorticoid receptors and glucocorticoid receptors are thought to be implicated in stress-related psychiatric diseases such as major depression. Because of its intriguing features, we focus in this review on the mineralocorticoid receptor and provide data which reveal novel aspects of the pharmacology and physiology of mineralocorticoid receptors. Newly obtained results are presented, which help to solve the paradox of why dexamethasone binds with high affinity to mineralocorticoid receptors in vitro, yet binds poorly in vivo. Until recently, mineralocorticoid receptor protein and mRNA levels could only be routinely studied with in vitro cytosol binding assays, in vitro and in vivo receptor autoradiography, Northern blot analysis, and in situ hybridization. These methods are unfortunately hampered by several flaws, such as the necessity of adrenalectomy, no or poor neuroanatomical resolution, the fact that mRNA does not provide the same information as protein, or combinations of these factors. We present immunohistochemical data on mineralocorticoid receptors in the brain obtained by using commercially available antibodies, which alleviate many of these shortcomings. Furthermore, an in vivo microdialysis method is presented which allows the assessment of free corticosterone levels in the brain, which is critical for the study of the pharmacological basis of mineralocorticoid receptor (and glucocorticoid receptor) function. Finally, a novel aspect of the regulation of mineralocorticoid receptors is described which provides evidence that this receptor system is dynamically regulated. In conjunction with previously reported effects of antidepressants, these results have initiated a new concept on the cause of the hypothalamic-pituitary-adrenocortical axis disturbances often seen in stress-related psychiatric disorders such as major depression.",
keywords = "Animals, Humans, Brain Chemistry, Receptors, Mineralocorticoid, Ligands",
author = "Reul, {J M} and A Gesing and S Droste and Stec, {I S} and A Weber and C Bachmann and A Bilang-Bleuel and F Holsboer and Linthorst, {A C}",
journal = "European Journal of Pharmacology: Molecular Pharmacology",
publisher = "Elsevier B.V.",
Reul, JM, Gesing, A, Droste, S, Stec, IS, Weber, A, Bachmann, C, Bilang-Bleuel, A, Holsboer, F & Linthorst, AC 2000, 'The brain mineralocorticoid receptor: greedy for ligand, mysterious in function', European Journal of Pharmacology: Molecular Pharmacology, vol. 405, no. 1-3, pp. 235-49.
The brain mineralocorticoid receptor : greedy for ligand, mysterious in function. / Reul, J M; Gesing, A; Droste, S; Stec, I S; Weber, A; Bachmann, C; Bilang-Bleuel, A; Holsboer, F; Linthorst, A C.
In: European Journal of Pharmacology: Molecular Pharmacology, Vol. 405, No. 1-3, 29.09.2000, p. 235-49.
T1 - The brain mineralocorticoid receptor
T2 - greedy for ligand, mysterious in function
AU - Reul, J M
AU - Gesing, A
AU - Droste, S
AU - Stec, I S
AU - Weber, A
AU - Bachmann, C
AU - Bilang-Bleuel, A
AU - Holsboer, F
AU - Linthorst, A C
N2 - Glucocorticoids exert their regulatory effects on the hypothalamic-pituitary-adrenocortical axis via two types of corticosteroid receptors: the glucocorticoid receptor and the mineralocorticoid receptor. Whereas the glucocorticoid receptor has a broad distribution in the brain, highest levels of mineralocorticoid receptor are found in the hippocampus. Based on the differential occupancy profile by endogenous glucocorticoids, glucocorticoid receptors are thought to mediate negative feedback signals of elevated glucocorticoid levels, whereas mineralocorticoid receptors control the inhibitory tone of the hippocampus on hypothalamic-pituitary-adrenocortical axis activity. Dysfunction of mineralocorticoid receptors and glucocorticoid receptors are thought to be implicated in stress-related psychiatric diseases such as major depression. Because of its intriguing features, we focus in this review on the mineralocorticoid receptor and provide data which reveal novel aspects of the pharmacology and physiology of mineralocorticoid receptors. Newly obtained results are presented, which help to solve the paradox of why dexamethasone binds with high affinity to mineralocorticoid receptors in vitro, yet binds poorly in vivo. Until recently, mineralocorticoid receptor protein and mRNA levels could only be routinely studied with in vitro cytosol binding assays, in vitro and in vivo receptor autoradiography, Northern blot analysis, and in situ hybridization. These methods are unfortunately hampered by several flaws, such as the necessity of adrenalectomy, no or poor neuroanatomical resolution, the fact that mRNA does not provide the same information as protein, or combinations of these factors. We present immunohistochemical data on mineralocorticoid receptors in the brain obtained by using commercially available antibodies, which alleviate many of these shortcomings. Furthermore, an in vivo microdialysis method is presented which allows the assessment of free corticosterone levels in the brain, which is critical for the study of the pharmacological basis of mineralocorticoid receptor (and glucocorticoid receptor) function. Finally, a novel aspect of the regulation of mineralocorticoid receptors is described which provides evidence that this receptor system is dynamically regulated. In conjunction with previously reported effects of antidepressants, these results have initiated a new concept on the cause of the hypothalamic-pituitary-adrenocortical axis disturbances often seen in stress-related psychiatric disorders such as major depression.
AB - Glucocorticoids exert their regulatory effects on the hypothalamic-pituitary-adrenocortical axis via two types of corticosteroid receptors: the glucocorticoid receptor and the mineralocorticoid receptor. Whereas the glucocorticoid receptor has a broad distribution in the brain, highest levels of mineralocorticoid receptor are found in the hippocampus. Based on the differential occupancy profile by endogenous glucocorticoids, glucocorticoid receptors are thought to mediate negative feedback signals of elevated glucocorticoid levels, whereas mineralocorticoid receptors control the inhibitory tone of the hippocampus on hypothalamic-pituitary-adrenocortical axis activity. Dysfunction of mineralocorticoid receptors and glucocorticoid receptors are thought to be implicated in stress-related psychiatric diseases such as major depression. Because of its intriguing features, we focus in this review on the mineralocorticoid receptor and provide data which reveal novel aspects of the pharmacology and physiology of mineralocorticoid receptors. Newly obtained results are presented, which help to solve the paradox of why dexamethasone binds with high affinity to mineralocorticoid receptors in vitro, yet binds poorly in vivo. Until recently, mineralocorticoid receptor protein and mRNA levels could only be routinely studied with in vitro cytosol binding assays, in vitro and in vivo receptor autoradiography, Northern blot analysis, and in situ hybridization. These methods are unfortunately hampered by several flaws, such as the necessity of adrenalectomy, no or poor neuroanatomical resolution, the fact that mRNA does not provide the same information as protein, or combinations of these factors. We present immunohistochemical data on mineralocorticoid receptors in the brain obtained by using commercially available antibodies, which alleviate many of these shortcomings. Furthermore, an in vivo microdialysis method is presented which allows the assessment of free corticosterone levels in the brain, which is critical for the study of the pharmacological basis of mineralocorticoid receptor (and glucocorticoid receptor) function. Finally, a novel aspect of the regulation of mineralocorticoid receptors is described which provides evidence that this receptor system is dynamically regulated. In conjunction with previously reported effects of antidepressants, these results have initiated a new concept on the cause of the hypothalamic-pituitary-adrenocortical axis disturbances often seen in stress-related psychiatric disorders such as major depression.
KW - Animals
KW - Brain Chemistry
KW - Receptors, Mineralocorticoid
KW - Ligands
JO - European Journal of Pharmacology: Molecular Pharmacology
JF - European Journal of Pharmacology: Molecular Pharmacology
Reul JM, Gesing A, Droste S, Stec IS, Weber A, Bachmann C et al. The brain mineralocorticoid receptor: greedy for ligand, mysterious in function. European Journal of Pharmacology: Molecular Pharmacology. 2000 Sep 29;405(1-3):235-49.


The Bible warns that "without a vision, the people perish." Michael Scott, the CEO of Pure Flix, provides answers to questions such as: How do we pursue God's vision for us? How do we navigate the inevitable obstacles? How does pursuing God's vision unleash our leadership? Michael Scott's bio.
Extraordinary Influence: How Great Leaders Bring Out the Best in Others | Dr. Tim Irwin | #38Special edition - "Living Out Your Faith in Life and Business"


Whatever your commute, trade or vocation, SsangYong Australia will back you.
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Sometimes the unexpected can happen. In the unlikely event you need assistance, help is just a phone call away.
Simply call 1800 957 454 to access SsangYong Roadside Assist.
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Finding the perfect French manicure designs can be an obsession for many women. There are so many designs to choose from and some can look absolutely amazing.
This type of manicure is now taking on a whole new look with many doing a black French manicure, which is the tips of the nails painted black instead of white.
There is the American manicure, a popular choice; it is a softer version of the French manicure. The tip of the nail is a softer, creamier color and gives a more natural look.
The American manicure also has the nail shaped to your fingernails, whereas the French manicure nail tip is filed straight across giving a more squared look.
To achieve a French manicure, you apply white nail polish to the tips of the nail and the rest of the nails are painted in a sheer nail polish, pale pink or light beige nail polish.
The French manicure looks great no matter what length your nails are. You don't have to have long fingernails.
Many will argue that the French manicure is coming to an end but I beg to differ, in fact it is as popular today as it ever was. No matter where you go, you are bound to see someone sporting this type of manicure. It is a timeless, dateless manicure and suits the young to the old and gives your fingernails a beautiful look.
With practice you can do this type of manicure yourself, usually though, many women will go to a salon to have it done. Just be careful the salon you are going to has a good reputation. Be wary of salons that do not clean their equipment as you are liable to catch a fungus infection, and you don't want this to happen as it can take months to clear up.
There are many salons which will use an airbrush machine to give the tip of the nail a smooth line for doing the white tips. The airbrush machine can also be used to create some amazing, wonderful designs.
You can always buy a manicure pen and do your own white tips at home, the manicure pen is also good for doing touch ups. If you have an artistic streak, you can do your own designs.
, and there are some wonderful designs you can have done for a wedding.


One of the main ways the general public encounters products of data analysis is through journalism. Data journalists strive to explain complex stories using visualization, statistics, and heavy use of contextualization. As we incorporate data science into the liberal arts, data journalism provides a case study as a field in which the sciences and the humanities are consciously linked. In this talk, I'll discuss the history of data journalism, how I see it fitting into a liberal arts framework, and experiences from a class I taught on data journalism.
Establishing a Think Tank on Data Science in the Liberal Arts: how do we imagine, design, and implement data science curriculums at small colleges; how do we more deeply connect data science to the liberal arts ethos.
Taking hands on approaches to curating, developing, and sharing liberal arts pedagogies and teaching materials for data science that broadly engage and support our students across the disciplines.
CHIANTI: Ample time devoted to collaborative workshopping on CHIANTI, the shared teaching resource for college-level language instruction; participants will explore the resources that have been gathered so far (including student and faculty reflection videos on liberal arts language learning), brainstorm on ideas for the emerging platform, and work on building additional content.
SKILLS DASHBOARD: Demonstration and brainstorming on the language skills question bank and dashboard prototype – initially developed for French last year, with future possibilities for other languages.
DIGITAL TOOLS for LANGUAGE LEARNING: Colleagues across LACOL shared experiences with digital pedagogies and tools for language instruction.
The real world is complicated, requiring mathematicians to approximate solutions and even the statement of real world problems!
In this class, you will learn powerful methods from classical algorithms to advanced linear algebra and their applications to the real world, specifically linear programming and random matrix theory.
CALL FOR PROPOSALS: Blended Learning in the Liberal Arts Conference at Bryn Mawr College May 22-23, 2019.
Submit by Feb. 25, 2019 at brynmawr.edu/blendedlearning/conference. Contact Jennifer Spohrer at blendedlearning@brynmawr.edu with questions.
Understanding of basic concepts in Bayesian statistics and ability to apply Bayesian inference approaches to solve scientific research problems and real-word problems.
Ability and skills to use statistical programming software (R/RStudio and JAGS) to realize Bayesian analysis.
Practice of reading, discussing, and critiquing statistics research journal papers.
In an increasingly globalized world, students are seeking ways to learn languages that are not commonly taught at schools in the United States. While self-instructional language programs (SILP) afford many opportunities to explore lesser-taught languages like Hindi, Korean, or Swahili, the scope of each program is limited. A new online collaboration will allow each program to tap into resources that other colleges in the consortium have, e.g. native speakers in the community that can serve as tutors, or advanced level instruction in certain languages. Students will have additional opportunities to explore new paths within their liberal arts education.
By sharing resources, the partners will be able to increase the number of self-instructional languages available to students in an innovative and cost-effective manner.
The self-instructional component of each language course will remain unchanged. Each student will enroll for the course at their home institution. For speaking and listening practice, students will join conversational tutorial sessions at a partnering college via video conferencing software, such as Zoom.
Familiarity and expertise in basic coding (R/RStudio).
Understanding of theory and application of basic concepts in statistics.
Ability to write and present technical material to diverse audiences.
Delivery is fully online with some scheduled and some asynchronous events.
Level: This class is intended for non-majors. There are no formal prerequisites; preference will be given for students with no prior coding experience; preference will be given to students who have taken college-level calculus. Enrollment must be approved by the student's advisor at their home institution and by a lead course instructor.
Abstract: Digital competency initiatives begin from shared global objectives but must adapt to local culture and structures to succeed. Collaboration helps define needs and goals, but how can we collaboratively assess programs that adopt intensely local variations? In this pre-conference workshop, we will present multiple examples of program development with overlapping goals. After examining existing efforts on attendees' campuses, they will develop plans for their own initiatives, considering local circumstances. We will then brainstorm with participants about how to collaboratively assess the impact of digital competency initiatives. Moreover, we will determine what evidence of impact would be meaningful to different stakeholders.
Yes, we changed our name!
Recently and for a while, stakeholders across our membership have agreed that the original name – Liberal Arts Consortium for Online Learning – only partly aligned with our current work, shared goals, and mission. After some deliberation, a name change was unanimously endorsed by our Faculty and Leadership Councils this fall.
Luckily, with our new name, LIBERAL ARTS COLLABORATIVE for Digital Innovation, we keep our familiar acronym: LACOL.
Dann Hurlbert and Palmar Alvarez-Blanco at Carleton College recently co-taught Spanish 206, a course focused on developing language skills with native speakers and fostering civic engagement–while also giving something tangible back to the community. Students in this course worked with under-represented local organizations to help them create a "participatory videos" (short documentaries) to help tell each organization's story. In addition to having students create video as a portion of their coursework, Dann also used instructional videos to teach and guide the learning. Dann created a successful Moodle-based micro-course that can now be easily replicated and plugged into a multitude of courses in which the faculty member hopes to tie Civic Engagement with his/her own course content, and video production.
*Note: this sample video includes short selections from the following films: Bacon and God's Wrath by Sol Friedman and Sarah Clifford-Rashotte; Godka Circa by Antonio Tibaldi and Alex Lora; Damon at 86th Street by Emily Sheskin, and the Price of Certainty by Daniele Anastasion.
Innovations in assessment can directly address a key challenge for our institutions – demonstrating our value in a time of increasing skepticism about the liberal arts.


text:
A mix of clouds and sun in the morning followed by cloudy skies during the afternoon. High around 60F. Winds ESE at 5 to 10 mph..
Cloudy skies. Low 57F. Winds SE at 10 to 20 mph.
David Collins
Marty Fluke
Brian Maxwell
Galveston council to consider calling $10 million May HOT vote
By JOSÉ MENDIOLA The Daily News
Jose Mendiola
The city council today will consider asking voters in May to weigh in on a charter amendment that would fundamentally change management of about $10 million a year in hotel occupancy tax revenue.
Council members will consider calling the referendum to seek change in a provision mandating the city give the Park Board of Trustees all revenue from 3 percent of the city's 15 percent hotel occupancy tax. That slice of the rate generates about $9.9 million a year and is restricted to spending on efforts to market and promote tourism.
City Councilman David Collins, who along with Mayor Craig Brown put the item on the agenda, said the change was needed to make the charter agree with the state tax code.
Aside from conflicting with state law, however, the charter now forces the city to give the convention and visitors bureau, which the Park Board operates under the name Visit Galveston, more marketing and promotional money than it has been spending each year, advocates of the change argue.
Visit Galveston budgets about $6.6 million but receives $9.9 million and banks the excess, about $3 million a year recently, in what Collins called a "slush fund" from which public money can be spent without much public oversight.
Park Board leaders, however, see the proposed change as a "war on tourism" that would put Visit Galveston's funding in the council hands, make it vulnerable to politics and hamstring efforts to promote tourism, which is arguably the island's most important industry.
"With no clearly communicated plan or process in place for this charter amendment, the overall economic impact of tourism on Galveston Island is in question," park board Chairman Marty Fluke said in a prepared statement Wednesday.
"As HOT is a tax on hotel rooms and paid by visitors, it is an economic benefit for residents. Tourism generates 40 percent of the property tax and 50 percent of the sales tax, reducing the tax burden on our residents."
Park board leaders also have pointedly objected to the idea the organization's spending lacks oversight and suggested the city would be more likely to misspend the money.
Collins, however, argued the change would not defund Visit Galveston, but would free up money that had been idle in Visit Galveston's budget for use to build a robust means for funding arts and cultural programs in the city.
"The CVB has been doing this work for decades and it does a good job," Collins said. "I don't think anyone at the city wants to take any money from the CVB, but it's not spending anywhere near $10 million a year."
A central question, among advocates for change at least, is the intent among voters who approved the existing charter provision in 1967.
At the time, the 3 percent was expected to generate about $90,000 a year, Collins said.
"Adjusted for inflation today, that's only $800,000 not $9.9 million," Collins has said.
The existing charter language prevents the community from exploiting the boon of a booming tourism industry to the fullest extent, City Manager Brian Maxwell said.
"It's like deciding you're going to devote a third of your income to paying your water bill," Maxwell said. "Maybe when you decided to do that it made sense, but after you start making a lot more income, it doesn't any more.
"Nobody wants to take any money from the CVB. I'm sure that if the park board came to the council with a budget to spend $10 million it would be approved.
"This is not a money grab. Nobody is saying we should pay the city's light bill with it or spend it on police. But it would free up money for arts and culture programs, which is legitimate spending that would benefit tourism and residents, it would enhance quality of life."
The deadline for the city to call a May referendum is Feb. 17, Collins said.
The next election date would be in November.
Collins argued there was no legitimate reason to delay the vote. If the council defers the vote Thursday, he and other advocates on the council would call a special meeting before the Feb. 17 deadline, he said.
Galveston City Council will meet at 5 p.m. at City Hall, 823 25th St.
José Mendiola: 409-683-5230 or jose.mendiola@galvnews.com
WHAT: Galveston City Council meeting
WHERE: City Hall, 823 25th St.
WHEN: 5 p.m. Thursday
Follow Jose Mendiola
Charlotte O'rourke Jan 25, 2023 10:53pm
When one has a monopoly, a guaranteed gig or contract, it's difficult if not impossible, to understand that one isn't a king. All of this recent strife stems from this idea of knowing competition does not exist due to a bizarre charter provision referencing an entity that does not exist in its voted upon form for over 50 years.
In 1967, there was a "beach park board" with very limited powers. Today we have a park board that uses public funds to sue private property owners, researches how to sue the state to take what the PB deems appropriate action against tax paying property owners, and spends public funds to fight the city for requesting that misappropriated Excess funds are returned to the city accounts where it earns interest.
It's time to let the citizens vote instead of blocking their right to vote by claiming a "war on tourism" instead of a war on abuse of power and monopolies and spending without any checks and balances by elected officials.
Yes tourism is very important and regardless of whether the charter section is removed or changed with the current terminology, 3 % will be spent on advertising.
By spending all this money on legal fees that does not put any heads in beds, one must wonder how the PB can claim to be a bastion of good spending habits and fiscal accountability.
What excuses will be given to prevent a residentbvote? I can't wait to hear the excuses.
Report Add Reply
Charlotte O'rourke Jan 26, 2023 11:49am
If I had to guess based on workshop, I believe council will defer this 3% charter topic and block the ability to vote in May. Maybe the residents will be allowed to vote in November.
As a fyi, there was confusion on the difference of excess funds from looking at budget and expenses and excess funds from that process and excess from undervaluing the penny and socking away the excess in reserves. And the significance of those amounts are huge.
Everyone should insist the PB start completing an ACFR - a special audit that has an introductory, financial, and statistical section so that new council member and the public can easily understand the issue. State law requires an ACFR for political bodies.
Approving a charter change on the 3 % required to go to the "beach park board" doesn't mean a defunding of the CVB. It means we would adhere to the state law code. Yes, please.
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Farmhouse now for sale on residential property market.
Local people came together following the bidder's architect's presentation at Fairmilehead Community Council meeting held 5 April 2016.
Liz Sim from Swan Spring Avenue lives opposite the entrance to the plot and is collecting email address of interested parties. Simon Newton from Pentland Drive operates this website.
Using the Contact Form below will send an email to the two of us, or use liz at comistonfarmhouse dot com directly.
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