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Project acronym 3DIMAGE
Project 3D Imaging Across Lengthscales: From Atoms to Grains
Researcher (PI) Paul Anthony Midgley
Summary "Understanding structure-property relationships across lengthscales is key to the design of functional and structural materials and devices. Moreover, the complexity of modern devices extends to three dimensions and as such 3D characterization is required across those lengthscales to provide a complete understanding and enable improvement in the material's physical and chemical behaviour. 3D imaging and analysis from the atomic scale through to granular microstructure is proposed through the development of electron tomography using (S)TEM, and 'dual beam' SEM-FIB, techniques offering complementary approaches to 3D imaging across lengthscales stretching over 5 orders of magnitude. We propose to extend tomography to include novel methods to determine atom positions in 3D with approaches incorporating new reconstruction algorithms, image processing and complementary nano-diffraction techniques. At the nanoscale, true 3D nano-metrology of morphology and composition is a key objective of the project, minimizing reconstruction and visualization artefacts. Mapping strain and optical properties in 3D are ambitious and exciting challenges that will yield new information at the nanoscale. Using the SEM-FIB, 3D 'mesoscale' structures will be revealed: morphology, crystallography and composition can be mapped simultaneously, with ~5nm resolution and over volumes too large to tackle by (S)TEM and too small for most x-ray techniques. In parallel, we will apply 3D imaging to a wide variety of key materials including heterogeneous catalysts, aerospace alloys, biomaterials, photovoltaic materials, and novel semiconductors. We will collaborate with many departments in Cambridge and institutes worldwide. The personnel on the proposal will cover all aspects of the tomography proposed using high-end TEMs, including an aberration-corrected Titan, and a Helios dual beam. Importantly, a postdoc is dedicated to developing new algorithms for reconstruction, image and spectral processing."
"Understanding structure-property relationships across lengthscales is key to the design of functional and structural materials and devices. Moreover, the complexity of modern devices extends to three dimensions and as such 3D characterization is required across those lengthscales to provide a complete understanding and enable improvement in the material's physical and chemical behaviour. 3D imaging and analysis from the atomic scale through to granular microstructure is proposed through the development of electron tomography using (S)TEM, and 'dual beam' SEM-FIB, techniques offering complementary approaches to 3D imaging across lengthscales stretching over 5 orders of magnitude. We propose to extend tomography to include novel methods to determine atom positions in 3D with approaches incorporating new reconstruction algorithms, image processing and complementary nano-diffraction techniques. At the nanoscale, true 3D nano-metrology of morphology and composition is a key objective of the project, minimizing reconstruction and visualization artefacts. Mapping strain and optical properties in 3D are ambitious and exciting challenges that will yield new information at the nanoscale. Using the SEM-FIB, 3D 'mesoscale' structures will be revealed: morphology, crystallography and composition can be mapped simultaneously, with ~5nm resolution and over volumes too large to tackle by (S)TEM and too small for most x-ray techniques. In parallel, we will apply 3D imaging to a wide variety of key materials including heterogeneous catalysts, aerospace alloys, biomaterials, photovoltaic materials, and novel semiconductors. We will collaborate with many departments in Cambridge and institutes worldwide. The personnel on the proposal will cover all aspects of the tomography proposed using high-end TEMs, including an aberration-corrected Titan, and a Helios dual beam. Importantly, a postdoc is dedicated to developing new algorithms for reconstruction, image and spectral processing."
Project acronym 3DNANOMECH
Project Three-dimensional molecular resolution mapping of soft matter-liquid interfaces
Researcher (PI) Ricardo Garcia
Host Institution (HI) AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Summary Optical, electron and probe microscopes are enabling tools for discoveries and knowledge generation in nanoscale sicence and technology. High resolution –nanoscale or molecular-, noninvasive and label-free imaging of three-dimensional soft matter-liquid interfaces has not been achieved by any microscopy method. Force microscopy (AFM) is considered the second most relevant advance in materials science since 1960. Despite its impressive range of applications, the technique has some key limitations. Force microscopy has not three dimensional depth. What lies above or in the subsurface is not readily characterized. 3DNanoMech proposes to design, build and operate a high speed force-based method for the three-dimensional characterization soft matter-liquid interfaces (3D AFM). The microscope will combine a detection method based on force perturbations, adaptive algorithms, high speed piezo actuators and quantitative-oriented multifrequency approaches. The development of the microscope cannot be separated from its applications: imaging the error-free DNA repair and to understand the relationship existing between the nanomechanical properties and the malignancy of cancer cells. Those problems encompass the different spatial –molecular-nano-mesoscopic- and time –milli to seconds- scales of the instrument. In short, 3DNanoMech aims to image, map and measure with picoNewton, millisecond and angstrom resolution soft matter surfaces and interfaces in liquid. The long-term vision of 3DNanoMech is to replace models or computer animations of bimolecular-liquid interfaces by real time, molecular resolution maps of properties and processes.
Optical, electron and probe microscopes are enabling tools for discoveries and knowledge generation in nanoscale sicence and technology. High resolution –nanoscale or molecular-, noninvasive and label-free imaging of three-dimensional soft matter-liquid interfaces has not been achieved by any microscopy method. Force microscopy (AFM) is considered the second most relevant advance in materials science since 1960. Despite its impressive range of applications, the technique has some key limitations. Force microscopy has not three dimensional depth. What lies above or in the subsurface is not readily characterized. 3DNanoMech proposes to design, build and operate a high speed force-based method for the three-dimensional characterization soft matter-liquid interfaces (3D AFM). The microscope will combine a detection method based on force perturbations, adaptive algorithms, high speed piezo actuators and quantitative-oriented multifrequency approaches. The development of the microscope cannot be separated from its applications: imaging the error-free DNA repair and to understand the relationship existing between the nanomechanical properties and the malignancy of cancer cells. Those problems encompass the different spatial –molecular-nano-mesoscopic- and time –milli to seconds- scales of the instrument. In short, 3DNanoMech aims to image, map and measure with picoNewton, millisecond and angstrom resolution soft matter surfaces and interfaces in liquid. The long-term vision of 3DNanoMech is to replace models or computer animations of bimolecular-liquid interfaces by real time, molecular resolution maps of properties and processes.
Project acronym ADHESWITCHES
Project Adhesion switches in cancer and development: from in vivo to synthetic biology
Researcher (PI) Mari Johanna Ivaska
Host Institution (HI) TURUN YLIOPISTO
Summary Integrins are transmembrane cell adhesion receptors controlling cell proliferation and migration. Our objective is to gain fundamentally novel mechanistic insight into the emerging new roles of integrins in cancer and to generate a road map of integrin dependent pathways critical in mammary gland development and integrin signalling thus opening new targets for therapeutic interventions. We will combine an in vivo based translational approach with cell and molecular biological studies aiming to identify entirely novel concepts in integrin function using cutting edge techniques and synthetic-biology tools. The specific objectives are: 1) Integrin inactivation in branching morphogenesis and cancer invasion. Integrins regulate mammary gland development and cancer invasion but the role of integrin inactivating proteins in these processes is currently completely unknown. We will investigate this using genetically modified mice, ex-vivo organoid models and human tissues with the aim to identify beneficial combinational treatments against cancer invasion. 2) Endosomal adhesomes – cross-talk between integrin activity and integrin "inside-in signaling". We hypothesize that endocytosed active integrins engage in specialized endosomal signaling that governs cell survival especially in cancer. RNAi cell arrays, super-resolution STED imaging and endosomal proteomics will be used to investigate integrin signaling in endosomes. 3) Spatio-temporal co-ordination of adhesion and endocytosis. Several cytosolic proteins compete for integrin binding to regulate activation, endocytosis and recycling. Photoactivatable protein-traps and predefined matrix micropatterns will be employed to mechanistically dissect the spatio-temporal dynamics and hierarchy of their recruitment. We will employ innovative and unconventional techniques to address three major unanswered questions in the field and significantly advance our understanding of integrin function in development and cancer.
Integrins are transmembrane cell adhesion receptors controlling cell proliferation and migration. Our objective is to gain fundamentally novel mechanistic insight into the emerging new roles of integrins in cancer and to generate a road map of integrin dependent pathways critical in mammary gland development and integrin signalling thus opening new targets for therapeutic interventions. We will combine an in vivo based translational approach with cell and molecular biological studies aiming to identify entirely novel concepts in integrin function using cutting edge techniques and synthetic-biology tools. The specific objectives are: 1) Integrin inactivation in branching morphogenesis and cancer invasion. Integrins regulate mammary gland development and cancer invasion but the role of integrin inactivating proteins in these processes is currently completely unknown. We will investigate this using genetically modified mice, ex-vivo organoid models and human tissues with the aim to identify beneficial combinational treatments against cancer invasion. 2) Endosomal adhesomes – cross-talk between integrin activity and integrin "inside-in signaling". We hypothesize that endocytosed active integrins engage in specialized endosomal signaling that governs cell survival especially in cancer. RNAi cell arrays, super-resolution STED imaging and endosomal proteomics will be used to investigate integrin signaling in endosomes. 3) Spatio-temporal co-ordination of adhesion and endocytosis. Several cytosolic proteins compete for integrin binding to regulate activation, endocytosis and recycling. Photoactivatable protein-traps and predefined matrix micropatterns will be employed to mechanistically dissect the spatio-temporal dynamics and hierarchy of their recruitment. We will employ innovative and unconventional techniques to address three major unanswered questions in the field and significantly advance our understanding of integrin function in development and cancer.
Project acronym AFTERTHEGOLDRUSH
Project Addressing global sustainability challenges by changing perceptions in catalyst design
Researcher (PI) Graham John Hutchings
Summary One of the greatest challenges facing society is the sustainability of resources. At present, a step change in the sustainable use of resources is needed and catalysis lies at the heart of the solution by providing new routes to carbon dioxide mitigation, energy security and water conservation. It is clear that new high efficiency game-changing catalysts are required to meet the challenge. This proposal will focus on excellence in catalyst design by learning from recent step change advances in gold catalysis by challenging perceptions. Intense interest in gold catalysts over the past two decades has accelerated our understanding of gold particle-size effects, gold-support and gold-metal interactions, the interchange between atomic and ionic gold species, and the role of the gold-support interface in creating and maintaining catalytic activity. The field has also driven the development of cutting-edge techniques, particularly in microscopy and transient kinetics, providing detailed structural characterisation on the nano-scale and probing the short-range and often short-lived interactions. By comparison, our understanding of other metal catalysts has remained relatively static. The proposed programme will engender a step change in the design of supported-metal catalysts, by exploiting the learning and the techniques emerging from gold catalysis. The research will be set out in two themes. In Theme 1 two established key grand challenges will be attacked; namely, energy vectors and greenhouse gas control. Theme 2 will address two new and emerging grand challenges in catalysis namely the effective low temperature activation of primary carbon hydrogen bonds and CO2 utilisation where instead of treating CO2 as a thermodynamic endpoint, the aim will be to re-use it as a feedstock for bulk chemical and fuel production. The legacy of the research will be the development of a new catalyst design approach that will provide a tool box for future catalyst development.
One of the greatest challenges facing society is the sustainability of resources. At present, a step change in the sustainable use of resources is needed and catalysis lies at the heart of the solution by providing new routes to carbon dioxide mitigation, energy security and water conservation. It is clear that new high efficiency game-changing catalysts are required to meet the challenge. This proposal will focus on excellence in catalyst design by learning from recent step change advances in gold catalysis by challenging perceptions. Intense interest in gold catalysts over the past two decades has accelerated our understanding of gold particle-size effects, gold-support and gold-metal interactions, the interchange between atomic and ionic gold species, and the role of the gold-support interface in creating and maintaining catalytic activity. The field has also driven the development of cutting-edge techniques, particularly in microscopy and transient kinetics, providing detailed structural characterisation on the nano-scale and probing the short-range and often short-lived interactions. By comparison, our understanding of other metal catalysts has remained relatively static. The proposed programme will engender a step change in the design of supported-metal catalysts, by exploiting the learning and the techniques emerging from gold catalysis. The research will be set out in two themes. In Theme 1 two established key grand challenges will be attacked; namely, energy vectors and greenhouse gas control. Theme 2 will address two new and emerging grand challenges in catalysis namely the effective low temperature activation of primary carbon hydrogen bonds and CO2 utilisation where instead of treating CO2 as a thermodynamic endpoint, the aim will be to re-use it as a feedstock for bulk chemical and fuel production. The legacy of the research will be the development of a new catalyst design approach that will provide a tool box for future catalyst development.
Project acronym ArtifiCell
Project Synthetic Cell Biology: Designing organelle transport mechanisms
Researcher (PI) James Edward Rothman
Summary Imagine being able to design into living cells and organisms de novo vesicle transport mechanisms that do not naturally exist? At one level this is a wild-eyed notion of synthetic biology. But we contend that this vision can be approached even today, focusing first on the process of exocytosis, a fundamental process that impacts almost every area of physiology. Enough has now been learned about the natural core machinery (as recognized by the award of the 2013 Nobel Prize in Physiology or Medicine to the PI and others) to take highly innovative physics/engineering- and DNA-based approaches to design synthetic versions of the secretory apparatus that could someday open new avenues in genetic medicine. The central idea is to introduce DNA-based functional equivalents of the core protein machinery that naturally form (coats), target (tethers), and fuse (SNAREs) vesicles. We have already taken first steps by using DNA origami-based templates to produce synthetic phospholipid vesicles and complementary DNA-based tethers to specifically capture these DNA-templated vesicles on targeted bilayers. Others have linked DNA oligonucleotides to trigger vesicle fusion. The next and much more challenging step is to introduce such processes into living cells. We hope to break this barrier, and in the process start a new field of research into "synthetic exocytosis", by introducing Peptide-Nucleic Acids (PNAs) of tethers and SNAREs to re-direct naturally-produced secretory vesicles to artificially-programmed targets and provide artificially-programmed regulation. PNAs are chosen mainly because they lack the negatively charged phosphate backbones of DNA, and therefore are more readily delivered into the cell across the plasma membrane. Future steps, would include producing the transport vesicles synthetically within the cell by externally supplied origami-based PNA or similar cages, and - much more speculatively - ultimately using encoded DNA and RNAs to provide these functions.
Imagine being able to design into living cells and organisms de novo vesicle transport mechanisms that do not naturally exist? At one level this is a wild-eyed notion of synthetic biology. But we contend that this vision can be approached even today, focusing first on the process of exocytosis, a fundamental process that impacts almost every area of physiology. Enough has now been learned about the natural core machinery (as recognized by the award of the 2013 Nobel Prize in Physiology or Medicine to the PI and others) to take highly innovative physics/engineering- and DNA-based approaches to design synthetic versions of the secretory apparatus that could someday open new avenues in genetic medicine. The central idea is to introduce DNA-based functional equivalents of the core protein machinery that naturally form (coats), target (tethers), and fuse (SNAREs) vesicles. We have already taken first steps by using DNA origami-based templates to produce synthetic phospholipid vesicles and complementary DNA-based tethers to specifically capture these DNA-templated vesicles on targeted bilayers. Others have linked DNA oligonucleotides to trigger vesicle fusion. The next and much more challenging step is to introduce such processes into living cells. We hope to break this barrier, and in the process start a new field of research into "synthetic exocytosis", by introducing Peptide-Nucleic Acids (PNAs) of tethers and SNAREs to re-direct naturally-produced secretory vesicles to artificially-programmed targets and provide artificially-programmed regulation. PNAs are chosen mainly because they lack the negatively charged phosphate backbones of DNA, and therefore are more readily delivered into the cell across the plasma membrane. Future steps, would include producing the transport vesicles synthetically within the cell by externally supplied origami-based PNA or similar cages, and - much more speculatively - ultimately using encoded DNA and RNAs to provide these functions.
Project acronym BCLYM
Project Molecular mechanisms of mature B cell lymphomagenesis
Researcher (PI) Almudena Ramiro
Host Institution (HI) CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)
Summary Most of the lymphomas diagnosed in the western world are originated from mature B cells. The hallmark of these malignancies is the presence of recurrent chromosome translocations that usually involve the immunoglobulin loci and a proto-oncogene. As a result of the translocation event the proto-oncogene becomes deregulated under the influence of immunoglobulin cis sequences thus playing an important role in the etiology of the disease. Upon antigen encounter mature B cells engage in the germinal center reaction, a complex differentiation program of critical importance to the development of the secondary immune response. The germinal center reaction entails the somatic remodelling of immunoglobulin genes by the somatic hypermutation and class switch recombination reactions, both of which are triggered by Activation Induced Deaminase (AID). We have previously shown that AID also initiates lymphoma-associated c-myc/IgH chromosome translocations. In addition, the germinal center reaction involves a fine-tuned balance between intense B cell proliferation and program cell death. This environment seems to render B cells particularly vulnerable to malignant transformation. We aim at studying the molecular events responsible for B cell susceptibility to lymphomagenesis from two perspectives. First, we will address the role of AID in the generation of lymphomagenic lesions in the context of AID specificity and transcriptional activation. Second, we will approach the regulatory function of microRNAs of AID-dependent, germinal center events. The proposal aims at the molecular understanding of a process that lies in the interface of immune regulation and oncogenic transformation and therefore the results will have profound implications both to basic and clinical understanding of lymphomagenesis.
Most of the lymphomas diagnosed in the western world are originated from mature B cells. The hallmark of these malignancies is the presence of recurrent chromosome translocations that usually involve the immunoglobulin loci and a proto-oncogene. As a result of the translocation event the proto-oncogene becomes deregulated under the influence of immunoglobulin cis sequences thus playing an important role in the etiology of the disease. Upon antigen encounter mature B cells engage in the germinal center reaction, a complex differentiation program of critical importance to the development of the secondary immune response. The germinal center reaction entails the somatic remodelling of immunoglobulin genes by the somatic hypermutation and class switch recombination reactions, both of which are triggered by Activation Induced Deaminase (AID). We have previously shown that AID also initiates lymphoma-associated c-myc/IgH chromosome translocations. In addition, the germinal center reaction involves a fine-tuned balance between intense B cell proliferation and program cell death. This environment seems to render B cells particularly vulnerable to malignant transformation. We aim at studying the molecular events responsible for B cell susceptibility to lymphomagenesis from two perspectives. First, we will address the role of AID in the generation of lymphomagenic lesions in the context of AID specificity and transcriptional activation. Second, we will approach the regulatory function of microRNAs of AID-dependent, germinal center events. The proposal aims at the molecular understanding of a process that lies in the interface of immune regulation and oncogenic transformation and therefore the results will have profound implications both to basic and clinical understanding of lymphomagenesis.
Project acronym BIO2CHEM-D
Project Biomass to chemicals: Catalysis design from first principles for a sustainable chemical industry
Researcher (PI) Nuria Lopez
Host Institution (HI) FUNDACIO PRIVADA INSTITUT CATALA D'INVESTIGACIO QUIMICA
Summary The use of renewable feedstocks by the chemical industry is fundamental due to both the depletion of fossil resources and the increasing pressure of environmental concerns. Biomass can act as a sustainable source of organic industrial chemicals; however, the establishment of a renewable chemical industry that is economically competitive with the present oil-based one requires the development of new processes to convert biomass-derived compounds into useful industrial materials following the principles of green chemistry. To achieve these goals, developments in several fields including heterogeneous catalysis are needed. One of the ways to accelerate the discovery of new potentially active, selective and stable catalysts is the massive use of computational chemistry. Recent advances have demonstrated that Density Functional Theory coupled to ab initio thermodynamics, transition state theory and microkinetic analysis can provide a full view of the catalytic phenomena. The aim of the present project is thus to employ these well-tested computational techniques to the development of a theoretical framework that can accelerate the identification of new catalysts for the conversion of biomass derived target compounds into useful chemicals. Since compared to petroleum-based materials-biomass derived ones are multifuncionalized, the search for new catalytic materials and processes has a strong requirement in the selectivity of the chemical transformations. The main challenges in the project are related to the high functionalization of the molecules, their liquid nature and the large number of potentially competitive reaction paths. The requirements of specificity and selectivity in the chemical transformations while keeping a reasonably flexible framework constitute a major objective. The work will be divided in three main work packages, one devoted to the properties of small molecules or fragments containing a single functional group; the second addresses competition in multiple functionalized molecules; and third is dedicated to the specific transformations of two molecules that have already been identified as potential platform generators. The goal is to identify suitable candidates that could be synthetized and tested in the Institute facilities.
The use of renewable feedstocks by the chemical industry is fundamental due to both the depletion of fossil resources and the increasing pressure of environmental concerns. Biomass can act as a sustainable source of organic industrial chemicals; however, the establishment of a renewable chemical industry that is economically competitive with the present oil-based one requires the development of new processes to convert biomass-derived compounds into useful industrial materials following the principles of green chemistry. To achieve these goals, developments in several fields including heterogeneous catalysis are needed. One of the ways to accelerate the discovery of new potentially active, selective and stable catalysts is the massive use of computational chemistry. Recent advances have demonstrated that Density Functional Theory coupled to ab initio thermodynamics, transition state theory and microkinetic analysis can provide a full view of the catalytic phenomena. The aim of the present project is thus to employ these well-tested computational techniques to the development of a theoretical framework that can accelerate the identification of new catalysts for the conversion of biomass derived target compounds into useful chemicals. Since compared to petroleum-based materials-biomass derived ones are multifuncionalized, the search for new catalytic materials and processes has a strong requirement in the selectivity of the chemical transformations. The main challenges in the project are related to the high functionalization of the molecules, their liquid nature and the large number of potentially competitive reaction paths. The requirements of specificity and selectivity in the chemical transformations while keeping a reasonably flexible framework constitute a major objective. The work will be divided in three main work packages, one devoted to the properties of small molecules or fragments containing a single functional group; the second addresses competition in multiple functionalized molecules; and third is dedicated to the specific transformations of two molecules that have already been identified as potential platform generators. The goal is to identify suitable candidates that could be synthetized and tested in the Institute facilities.
Project acronym BioDisOrder
Project Order and Disorder at the Surface of Biological Membranes.
Researcher (PI) Alfonso DE SIMONE
Summary Heterogeneous biomolecular mechanisms at the surface of cellular membranes are often fundamental to generate function and dysfunction in living systems. These processes are governed by transient and dynamical macromolecular interactions that pose tremendous challenges to current analytical tools, as the majority of these methods perform best in the study of well-defined and poorly dynamical systems. This proposal aims at a radical innovation in the characterisation of complex processes that are dominated by structural order and disorder, including those occurring at the surface of biological membranes such as cellular signalling, the assembly of molecular machinery, or the regulation vesicular trafficking. I outline a programme to realise a vision where the combination of experiments and theory can delineate a new analytical platform to study complex biochemical mechanisms at a multiscale level, and to elucidate their role in physiological and pathological contexts. To achieve this ambitious goal, my research team will develop tools based on the combination of nuclear magnetic resonance (NMR) spectroscopy and molecular simulations, which will enable probing the structure, dynamics, thermodynamics and kinetics of complex protein-protein and protein-membrane interactions occurring at the surface of cellular membranes. The ability to advance both the experimental and theoretical sides, and their combination, is fundamental to define the next generation of methods to achieve our transformative aims. We will provide evidence of the innovative nature of the proposed multiscale approach by addressing some of the great questions in neuroscience and elucidate the details of how functional and aberrant biological complexity is achieved via the fine tuning between structural order and disorder at the neuronal synapse.
Heterogeneous biomolecular mechanisms at the surface of cellular membranes are often fundamental to generate function and dysfunction in living systems. These processes are governed by transient and dynamical macromolecular interactions that pose tremendous challenges to current analytical tools, as the majority of these methods perform best in the study of well-defined and poorly dynamical systems. This proposal aims at a radical innovation in the characterisation of complex processes that are dominated by structural order and disorder, including those occurring at the surface of biological membranes such as cellular signalling, the assembly of molecular machinery, or the regulation vesicular trafficking. I outline a programme to realise a vision where the combination of experiments and theory can delineate a new analytical platform to study complex biochemical mechanisms at a multiscale level, and to elucidate their role in physiological and pathological contexts. To achieve this ambitious goal, my research team will develop tools based on the combination of nuclear magnetic resonance (NMR) spectroscopy and molecular simulations, which will enable probing the structure, dynamics, thermodynamics and kinetics of complex protein-protein and protein-membrane interactions occurring at the surface of cellular membranes. The ability to advance both the experimental and theoretical sides, and their combination, is fundamental to define the next generation of methods to achieve our transformative aims. We will provide evidence of the innovative nature of the proposed multiscale approach by addressing some of the great questions in neuroscience and elucidate the details of how functional and aberrant biological complexity is achieved via the fine tuning between structural order and disorder at the neuronal synapse.
Project acronym CAPRI
Project Chemical and photochemical dynamics of reactions in solution
Researcher (PI) Andrew John Orr-Ewing
Host Institution (HI) UNIVERSITY OF BRISTOL
Summary Ultrafast laser methods will be employed to examine the dynamics of chemical and photochemical reactions in liquid solutions. By contrasting the solution phase dynamics with those observed for isolated collisions in the gas phase, the fundamental role of solvent on chemical pathways will be explored at a molecular level. The experimental studies will be complemented by computational simulations that explicitly include treatment of the effects of solvent on reaction energy pathways and reactant and product motions. The research addresses a major challenge in Chemistry to understand the role of solvent on the mechanisms of chemical reactions. Questions that will be examined include how the solvent modifies reaction barriers and other regions of the reaction potential energy surface (PESs), alters the couplings between PESs, most importantly at conical intersections between electronic states, influences and constrains the dynamical stereochemistry of passage through transition states, and dissipates excess product energy. The experimental strategy will be to obtain absorption spectra of transient species with lifetimes of ~100 fs – 1000 ps using broad bandwidth light sources in the infrared, visible and ultraviolet regions. Time-evolutions of such spectra reveal the formation and decay of short-lived species that might be highly reactive radicals or internally (vibrationally and electronically) excited molecules. The transient species decay by reaction or energy loss to the solvent. Statistical mechanical theories of reactions in solution treat such processes using linear response theory, but the experimental data will challenge this paradigm by seeking evidence for breakdown of the linear response interaction of solvent and solute on short timescales because of microscopic chemical dynamics that perturb the solvent structure. The work will build on our pioneering experiments at the Rutherford Appleton Laboratory that prove the feasilbility of the methods.
Ultrafast laser methods will be employed to examine the dynamics of chemical and photochemical reactions in liquid solutions. By contrasting the solution phase dynamics with those observed for isolated collisions in the gas phase, the fundamental role of solvent on chemical pathways will be explored at a molecular level. The experimental studies will be complemented by computational simulations that explicitly include treatment of the effects of solvent on reaction energy pathways and reactant and product motions. The research addresses a major challenge in Chemistry to understand the role of solvent on the mechanisms of chemical reactions. Questions that will be examined include how the solvent modifies reaction barriers and other regions of the reaction potential energy surface (PESs), alters the couplings between PESs, most importantly at conical intersections between electronic states, influences and constrains the dynamical stereochemistry of passage through transition states, and dissipates excess product energy. The experimental strategy will be to obtain absorption spectra of transient species with lifetimes of ~100 fs – 1000 ps using broad bandwidth light sources in the infrared, visible and ultraviolet regions. Time-evolutions of such spectra reveal the formation and decay of short-lived species that might be highly reactive radicals or internally (vibrationally and electronically) excited molecules. The transient species decay by reaction or energy loss to the solvent. Statistical mechanical theories of reactions in solution treat such processes using linear response theory, but the experimental data will challenge this paradigm by seeking evidence for breakdown of the linear response interaction of solvent and solute on short timescales because of microscopic chemical dynamics that perturb the solvent structure. The work will build on our pioneering experiments at the Rutherford Appleton Laboratory that prove the feasilbility of the methods.
Project acronym CARBONICE
Project Carbon – Ice Composite Materials: Water Structure and Dynamics at the Carbon Interface
Researcher (PI) Christoph Günter SALZMANN
Summary Carbon and water in its various states of matter make up a substantial proportion of our Universe. The two materials are highly dissimilar with respect to their chemical and physical properties. Elemental carbon is even often referred to as a hydrophobic, 'water-hating' material. Yet, the two materials often coexist and critical processes take place at the interface between these unlike chemical species. This includes the hydration shells of hydrophobic moieties in biomolecules, clathrate hydrate materials where water molecules crystallise around hydrophobic guest species as well as icy comets which are often black due to the presence of carbon at their surfaces. The aim of the CARBONICE project is to investigate the interface and interplay between water and carbon in detail. Using new and innovative experimental strategies, the water molecule will be placed in a variety of different yet highly relevant carbon environments. This will give us unprecedented insights into how water hydrates hydrophobic species which is highly important in the context of hydrophobic interactions. Investigations into how carbon species influence phase transitions of ice will give new insights into crystallisation phenomena but will also reveal the factors that lead to the formation of either ferro- or antiferroelectric ices. Creating carbon – ice composites in the lab as they exist on comets will enable us to understand the complex weather cycles on comets and may help explaining the unusual surface features recently identified by the Rosetta space probe. In summary, this truly multidisciplinary project opens up a new spyhole to critically important processes at the water – carbon interface. The results will have an impact on the space, atmospheric and general materials sciences but will also be highly relevant with respect to further optimising the computer models of water as well as understanding the properties of water in nano-confinements and how it drives biological processes.
Carbon and water in its various states of matter make up a substantial proportion of our Universe. The two materials are highly dissimilar with respect to their chemical and physical properties. Elemental carbon is even often referred to as a hydrophobic, 'water-hating' material. Yet, the two materials often coexist and critical processes take place at the interface between these unlike chemical species. This includes the hydration shells of hydrophobic moieties in biomolecules, clathrate hydrate materials where water molecules crystallise around hydrophobic guest species as well as icy comets which are often black due to the presence of carbon at their surfaces. The aim of the CARBONICE project is to investigate the interface and interplay between water and carbon in detail. Using new and innovative experimental strategies, the water molecule will be placed in a variety of different yet highly relevant carbon environments. This will give us unprecedented insights into how water hydrates hydrophobic species which is highly important in the context of hydrophobic interactions. Investigations into how carbon species influence phase transitions of ice will give new insights into crystallisation phenomena but will also reveal the factors that lead to the formation of either ferro- or antiferroelectric ices. Creating carbon – ice composites in the lab as they exist on comets will enable us to understand the complex weather cycles on comets and may help explaining the unusual surface features recently identified by the Rosetta space probe. In summary, this truly multidisciplinary project opens up a new spyhole to critically important processes at the water – carbon interface. The results will have an impact on the space, atmospheric and general materials sciences but will also be highly relevant with respect to further optimising the computer models of water as well as understanding the properties of water in nano-confinements and how it drives biological processes.


Old Doc Honeymill's got the cure for your heartburn; a brand new, slightly rusty, mechanical, keyhole heart! Sure, it might be overkill. Sure, you'll probably get sepsis. And sure, Doc Honeymill might not actually be a doctor.
But hey. This is the Old West. You take what you can get.


text:
Q: is it too early to use the websockets?
Possible Duplicate:
WebSocket for HTML5

Hello,
I would like to use http://dev.w3.org/html5/websockets/
can I start or is it too early and no browser support it yet
Thank you

A: At the present time you can use something like socket.io library to provide fallback for browsers which don't support WebSocket functionality. Flash sockets or long polling will be used instead.

redpajama_set_name: RedPajamaStackExchange


text:
Pretty soon I am buying new clothes. Then new clothes again. And again. Then the dreaded stall or plateau hits. It's hard to stay motivated when you're used to seeing 4-6lbs a week fall off like magic, but I'm in it for the Long haul. I had probably 3 or 4 stalls in the last 20 months, each one took me a different tactic to overcome. Now I like to call them Milestones instead of stalls.
Pretty soon results start to show and success snowballs in to more success. I started to experiment with recipes. Making my own spice blends (taco seasoning, chili seasoning,Cajun seasoning, etc) making dressings (BBQ sauce, thousand island) and trying to cook more. Mostly slow cooker recipes like crack chicken or chili or Mississippi roast. This is kinda fun!
Lots of apps and websites offer keto diet challenges—basically, a blueprint for the keto diet with a fixed starting and ending point (they typically last for a week to a month, though some may be longer). Speaking of apps, plenty of keto-centric ones are right at your fingertips (a.k.a., your smartphone), like the KetoDiet app, which can help you calculate your macros and track your keto diet effectively.
The ketogenic diet is a medical nutrition therapy that involves participants from various disciplines. Team members include a registered paediatric dietitian who coordinates the diet programme; a paediatric neurologist who is experienced in offering the ketogenic diet; and a registered nurse who is familiar with childhood epilepsy. Additional help may come from a medical social worker who works with the family and a pharmacist who can advise on the carbohydrate content of medicines. Lastly, the parents and other caregivers must be educated in many aspects of the diet for it to be safely implemented.[5]
Sleep enough – for most people at least seven hours per night on average – and keep stress under control. Sleep deprivation and stress hormones raise blood sugar levels, slowing ketosis and weight loss a bit. Plus they might make it harder to stick to a keto diet, and resist temptations. So while handling sleep and stress will not get you into ketosis on it's own, it's still worth thinking about.
There are three instances where there's research to back up a ketogenic diet, including to help control type 2 diabetes, as part of epilepsy treatment, or for weight loss, says Mattinson. "In terms of diabetes, there is some promising research showing that the ketogenic diet may improve glycemic control. It may cause a reduction in A1C — a key test for diabetes that measures a person's average blood sugar control over two to three months — something that may help you reduce medication use," she says.
The ketogenic diet has been studied in at least 14 rodent animal models of seizures. It is protective in many of these models and has a different protection profile than any known anticonvulsant. Conversely, fenofibrate, not used clinically as an antiepileptic, exhibits experimental anticonvulsant properties in adult rats comparable to the ketogenic diet.[58] This, together with studies showing its efficacy in patients who have failed to achieve seizure control on half a dozen drugs, suggests a unique mechanism of action.[56]
Epilepsy is one of the most common neurological disorders after stroke,[7] and affects around 50 million people worldwide.[8] It is diagnosed in a person having recurrent, unprovoked seizures. These occur when cortical neurons fire excessively, hypersynchronously, or both, leading to temporary disruption of normal brain function. This might affect, for example, the muscles, the senses, consciousness, or a combination. A seizure can be focal (confined to one part of the brain) or generalised (spread widely throughout the brain and leading to a loss of consciousness). Epilepsy can occur for a variety of reasons; some forms have been classified into epileptic syndromes, most of which begin in childhood. Epilepsy is considered refractory (not yielding to treatment) when two or three anticonvulsant drugs have failed to control it. About 60% of patients achieve control of their epilepsy with the first drug they use, whereas around 30% do not achieve control with drugs. When drugs fail, other options include epilepsy surgery, vagus nerve stimulation, and the ketogenic diet.[7]
Note: Because you'll be excluding some major food groups on the keto diet (grains, many fruits) you should definitely think about taking a multivitamin—especially one that contains folic acid, which helps your body make new cells and is often found in enriched breads, cereals, and other grain products, says Julie Upton, R.D., cofounder of nutrition website Appetite for Health.
Italiano: Perdere Peso, Español: bajar de peso, Deutsch: Abnehmen, Português: Perder Peso, Nederlands: Afvallen, Français: perdre du poids, Русский: сбросить вес, 中文: 减肥, Čeština: Jak zhubnout, Bahasa Indonesia: Menurunkan Berat Badan, 日本語: ダイエット, ไทย: ลดน้ำหนัก, Tiếng Việt: Giảm Cân, हिन्दी: वज़न कम करें (kaise vajan kam kare), 한국어: 체중 감량하는 법, Türkçe: Nasıl Kilo Verilir https://www.pinterest.com/PhilosophyOfHealthOrg/

redpajama_set_name: RedPajamaCommonCrawl


Every day, we feature an image chosen from thousands submitted to our photo community, Your Shot. Here are some of the month's highlights.
From the vibrant streets of Cape Town's Bo-Kaap neighborhood to the vivid stained glass windows of Iran's famous Pink Mosque, the top shots from last month expertly utilized color in order to stand out. Check out these eye-catching scenes from around the world.
Francis Rivera produces Photo of the Day, a curated look at photography from National Geographic's photo community, Your Shot . Melody Rowell writes and researches the captions. Submit your photos and you could be published online or in our magazines. See the highlights from previous months here.


Sweet, spicy, biscuit and fruit are the most prominent flavors in this Old Tom Gin. It's distilled by Tanqueray and bottled at 47.3% ABV.
What does Tanqueray Old Tom Gin taste like?
The Flavor Spiral™ shows the most common flavors that you'll taste in Tanqueray Old Tom Gin and gives you a chance to have a taste of it before actually tasting it.


Our range of European Softwood Flooring is available in both Redwood and Whitewood species and is machined from quality Scandinavian / Russian Softwood. All are produced using kiln dried timber to reduce the risk of shrinkage (although, dependent on the specific application some shrinkage may still occur) although both species are produced using high quality raw material,Redwood is typically used for its enhanced appearance - where the floor is to be left exposed and Whitewood typically where the floor is to be covered (under carpet etc). All our profiles are planed all round with offset tongue and groove and finished widths and thicknesses are to BS/EN specifications.


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The Tufts Daily
The independent student newspaper of Tufts University
A Blight on the Hill
The Rewind
Out of Curiosity
Love Is Dead at Tufts
Listening sessions held to gather information on student mental health
Hannah Uebele
Counseling and Mental Health Services is located at the corner of Curtis Street and Curtis Avenue. Alex Cherry / The Tufts Daily Archive
Tufts' Mental Health Task Force, formed by University President Anthony Monaco last semester, has begun to conduct listening sessions with student organizations to collect input on student mental health.
The task force is charged with reviewing the state of mental health for students on all Tufts campuses, examining the successes and limitations of the university's mental health resources and offering policy and outreach recommendations, according to the Office of the President's website.
"The goal of the listening sessions is to engage students in a dialogue to gain a better understanding of the needs, concerns and potential solutions to strengthening student mental health at Tufts," Jacklyn Varela, communications and project administrator of the Office of the President, told the Daily in an email.
The first listening sessions started this month, and Varela explained that the task force plans to continue them into the next school year.
"We very much see these listening sessions as the beginning of a dialogue and look forward to continuing these conversations into the fall," she said.
Senior Associate Dean of Student Affairs Raymond Ou, who co-chairs the task force's working group on undergraduate students, explained that the listening sessions are a way for the task force to gain information on how to best achieve the group's charge and purpose.
"Understanding the student experience, needs and concerns is vital to our ability to make informed decisions. Emerging themes will help the working group prioritize its work over the summer," Ou told the Daily in an email.
Varela explained that, in a listening session, she and a member of the working group typically attend to introduce students to the task force's role, facilitate the conversation and take notes. Sessions are organized as an opportunity for students to share their thoughts.
"We have a list of prepared questions, but so far we have found these sessions tend to flow organically and cover a range of intersecting issues. For us, it's really about listening," Varela wrote.
Sophomore William McKenna serves as an undergraduate representative on the working group that focuses on undergraduate students. McKenna, who is a member of the executive board of Active Minds at Tufts, works as a liaison between students and administrators.
The listening sessions will be held with different groups and spaces on campus, including the Asian American Center, Africana Center and Latino Center, in the hopes of hearing the many voices of the Tufts community, according to McKenna.
"Our goal is to go to many diverse populations within the Tufts community, because different parts of your identity will affect your experience with mental health, your experience within Tufts and your attitude towards resources," McKenna said.
The listening sessions further attempt to gather information about what barriers certain groups within the school feel in relation to accessing Counseling and Mental Health Services as well as stories they've heard from other students and their beliefs about the school's policies, according to McKenna.
McKenna added that open panels are also being held for all students to attend, but he described how it can be hard to attract a large turnout.
"I think a hard part about it is getting people to learn about these open meetings," he said. "The whole barrier of having people [be] aware of these sessions is an issue within itself, but that's something that we have acknowledged as the task force."
McKenna further noted that there is a website where members of the Tufts community can share their own experiences anonymously to the task force.
"That's important because a hard part about going to these conference meetings is that you're a face associated to a story, and you might not feel comfortable associating with your story yet," he said.
Jennifer Stephan, associate dean of undergraduate advising to the School of Engineering and co-chair of the working group focused on undergraduates, explained that the task force hopes to use the information it collects to understand students' concerns and experiences about mental health.
"We're planning to use the qualitative data that we collect through these sessions to help us gain a better understanding of our students' experience using and accessing the range of services available and identifying barriers and gaps along the way," Stephan told the Daily in an email. "We are also eager to better understand, in the most holistic sense, Tufts' culture and how it may mitigate or exacerbate student mental health."
Stephan further explained that the task force's goal is to make preliminary recommendations next fall, in part by using the information it learns from the listening sessions.
"We have been asked to provide recommendations in three areas: (1) education, outreach and mental health promotion, (2) services and resources and (3) policies and practices," Stephan said.
Varela described how the task force will continue working to achieve its goals and what it has planned next.
"Next, we'd like to engage faculty and staff in a similar fashion. Over the summer, our plans are to really dig deep into fulfilling the work laid out in the charge," she said.
Top This Week
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Madeleine AitkenJanuary 16, 2020
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BREAKING: Tufts begins review of investments in fossil fuel industry
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Letter from the Managing Board regarding Nov. 18 editorial
Tufts DailyJanuary 13, 2020
Editorial: Welcome back, Jumbos
Black Solidarity Day: What does it mean?
Ben SerranoOctober 29, 2009
'A Hidden Life' reveals too little
Tuna MargalitSeptember 25, 2019
COPYRIGHT 2020 THE TUFTS DAILY. ALL RIGHTS RESERVED.


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Monday 30th January 2023,
Rockets Spin Out of Control
Rob May 29, 2018 R.S. De France 1 Comment on Rockets Spin Out of Control
As the Houston Rockets gave up a 15-point lead and lost game 7 of the Western Conference Finals to the Golden State Warriors, 101-92, it became a little hard not to look around and start pointing fingers. At least for me. Somewhat surprisingly, neither James Harden, Eric Gordon, nor Head Coach Mike D'Antoni were anything less than true professionals during their post-game interviews, so then let me be one of the first to start throwing shade (at someone besides the refs).
There are plenty of reasons why the Rockets failed to close out the series in two consecutive games. Oddly enough, it seems like D'Antoni knows the problem(s), but he refuses to adjust his game plan accordingly. After the Rockets game 6 loss, D'Antoni admitted that it "kind of goes hand-in-hand between, you know, getting good offense and having stops."
And that was the ball game. Between the Rockets' lack of sustained defense and their lack of a coherent offensive strategy, they just didn't have enough to best the defending champions.
Game 7 Highlights
Like we should have expected with Harden and D'Antoni, the Rockets had problems defensively.
Throughout the game, the Rockets had—if not poor defense—at least defensive lapses that are inexcusable of a team trying to win a championship.
In the first period, Stephen Curry got a steal and Harden left him wide open to nail a three-pointer. Later in the opening quarter, Draymond Green slashed in for an almost uncontested dunk during a fast break.
In the 3rd quarter, during which the Warriors outscored the Rockets 33-15, P.J. Tucker didn't even close out on Curry for a three-point shot that cut the Rockets lead to 61-58 (of course there was a moving screen on the play, but it didn't affect Tucker). In the 4th quarter, the Rockets' lack of defense was best exemplified by Gerald Green's inability to close out on shooters.
The Warriors' big stars finished with 34 points and 3 blocks for All-star Kevin Durant, 19 points for Klay Thompson (who got in early foul trouble), and a near-triple-double for Curry: 27 points, 10 assists, 9 rebounds, and 4 steals.
The real problems for the Rockets were their offensive and defensive strategies, which sadly fall squarely on Coach Mike D'Antoni, who I like. He's seems like a really nice guy, but there is a reason his teams have never made the NBA Finals.
After their game 6 loss, D'Antoni said something very telling. "We shot 50% from threes in the first half…you're not gonna shoot 50% the whole game." Again, he seems to know there is a problem but sticks with a flawed strategy nonetheless.
It's like former NBA All-star forward Chris Webber said of the Rockets during game 7: "their strategy doesn't take advantage." Webber suggested that they need to drive to the hoop when the other team is in the bonus.
Since we covered the Rockets' lack of inspired defense, let's move on to the Rockets' offensive scheme, although calling it that may be giving them too much credit. Everyone noticed how they missed 27 straight threes and went 7/44 from beyond the arc in game 7. The Warriors, on the other hand, shot 16/39 (41%) from the outside and 48.8% from the field.
At a certain point, the Rockets needed to make in-game adjustments, which they did not. Even after the game, Harden, who had 32 points, 6 rebounds, 6 assists, and went 2/13 from three, defended their "strategy" of nonchalantly chucking up three-balls. "We're just gonna keep shootin' 'em…we just didn't make 'em," Harden proclaimed. He was also a -13 in +/-.
When asked (post-game) if he thought about changing the Rockets' strategy of shooting about 40 threes per game, D'Antoni said bluntly, "No."
For the record, Trevor Ariza, Gordon, and Harden went 4/34 (11%) from beyond the arc in game 7. Ariza finished 0/12 (0/9 from three), which really bothers me. Ariza is a great slasher, who doesn't need to be sitting on the three-point line the whole game. Gordon had 23 points but went 2/12 from distance.
One reason for hope for the Rockets was 24-year-old Clint Capela, who had 20 points and 9 rebounds. For a while, it looked like they could have kept feeding him on the inside until he had 40 points, and perhaps they should have.
The Rockets with a healthy Chris Paul might have won the game and moved on to the NBA Finals, besides they won the offensive rebound battle 17-11 and only turned the ball over 12 times (compared to the Warriors' 16), but shooting 40% from the field, 15% from three, and 50-something% from the free throw line will never get it done in this league. And the Rockets need to come up with a better strategy than we're gonna shoot a ton of threes, and if we lose then "so be it."
How Will Russell Westbrook Fit in with The Rockets?
Mike D'Antoni Remains in Hospital With Intestinal Virus
Houston Rockets and GM Daryl Morey Agree to 5-Year Extension


March 9, 2015 Students, Superintendent search.
Palm Beach County's public school system has received record-setting feedback after asking the public to weigh in on what qualities the next schools superintendent should have.
With more than 3,400 people completing the communication department's online survey, much of the feedback was thoughtful, constructive, and undoubtedly helpful for those leading the search.
Teachers talked about the importance of classroom experience. Parents commented on the need to reduce standardized testing.
But what about the students? Didn't someone ask them?
Included some very specific requests….
And included our personal favorite…..
* DISCLAIMER: We cannot rule out the disturbing possibility that some of these anonymous comments were provided by non-students.


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Read about the state-of-the-art facilities and classes that prepare students for a technology career.
College of Computer & Information Technology at SPC
College Blogs Home
All posts by Laura Malave
SPC Cybersecurity Club, TitanSec, participates in National Cyber League (NCL) Spring 2019 Season
July 8, 2019 Blue & White, College of Computer and Information Technology, FeaturedCharleston Fritts and Laura Malave
With the help of the Carl D. Perkins IV federal grant, 37 students from St. Petersburg College's Cybersecurity Club, TitanSec, were able to participate in the National Cyber League (NCL) 2019 spring season. The students were led by Faculty Advisor and CCIT Academic Chair, Coach Laura Malave, as well as SPC Certification Testing Coordinator, Ms. Julia Meyer.
National Cyber League
The NCL is an online high school and collegiate Capture the Flag
(CTF) competition that helps students prepare for the types of technical challenges they will face in the workforce. Challenges during the competition align with CompTIA Security+ and EC-Council Certified Ethical Hacker industry certification competencies.
Participants were challenged with topics such as Open Source Intelligence, Scanning, Enumeration and Exploitation, Password Cracking, Traffic Analysis, Log Analysis, Wireless Security, Cryptography, and Web Application Security.
The NCL spring season consisted of three phases:
Preseason (for bracket placement in Gold, Silver, or Bronze skill levels)
Students who participate in the NCL receive a Scouting Report, which tracks their personal growth and can be shared with potential employers. They also receive continued access to the NCL Gymnasium, an area where students can practice and work on developing their skills through guided challenges.
TitanSec ranking in the NCL
SPC had 37 participants with 577 average points, and 58.67% average accuracy. The top three players for preseason were Steve Whitehurst, Anthony Muratori, and Trey Johnson.
SPC had 37 participants with 729 average points, and 69.75% average accuracy. The top three players were Anothny Muratori, Nathan Papanicolas, and Trey Johnson.
SPC had two teams compete during this phase of the NCL. The first team, microsoft_sucks (titansec), scored 2,370 points with a 75.47% accuracy. Team members included Nathan Turner, Thuc Nguyen, Anthony Muratori, Christopher Agresta, Nathan Papanicolas, Dawn Kimber, and Marcus Dilorenzo.
The second team, Titansec0x01, scored 1,615 points with a 55% accuracy. This team was made up by Jennifer Nicole Milfor, Ryan Everett-Qualters, Suzanne Jensen, and Christopher Vaden.
You could be next to compete in the National Cyber League!
St. Petersburg College offers a robust educational experience for those interested in cybersecurity. Our certificate and Associate of Science degree will teach you hands-on and technical skills to get you started in the cybersecurity sector, while the Bachelor of Applied Science will help you develop the IT-related management skills needed to move up in the industry. These programs will prepare you to meet the growing need for college-educated security professionals who can handle complex information technology security concerns.
Learn more about St. Petersburg College's Cybersecurity programs.
SPC Cybersecurity & Digital Forensics Club Attends BSides Tampa 2018
February 23, 2018 College of Computer and Information Technology, CybersecurityCharleston Fritts and Laura Malave
BSides Tampa is a yearly Information Security Conference hosted by the Tampa Bay Chapter of (ISC)2. The BSides Tampa conference focuses on providing attendees with the latest in information security research, development, and exploits. The conference featured various presentations and demonstrations from the best minds in industry and academia. More than 750 attendees also participated in Electronic Badge Assembly, Lock Pick Village, Car Hacking Village, Capture the Flag competition, Escape Room, and Resume Review.
Club advisor and CCIT Academic Chair Laura Malave, Club President Michael Milford, and club member Frances Sanchez had the opportunity to participate in the conference as volunteers. SPC students/club members in attendance included: Nathan Turner, Thuc Nguyen, Sabrina Mitchell, Jesus Pernia, Bradley Meister, Rodney Dillota, Jacob Bertramsen, and Violeta Tutka.
Students share experience on BSides Tampa
"I had a great time volunteering at BSides, and it was great so many other students attended. I hope to see more of our students volunteering and attending Bsides Tampa," Milford said about his BSides experience.
"We had so much fun at this conference and grew as a team by working together in the Escape Room and generally navigating around the events. In addition, we met with a few community organizations and continued to expand those relationships. Overall, it was a very successful event!" Sanchez said regarding her BSides experience.
For additional information on the Cybersecurity & Digital Forensics Club, please contact, Club Advisor Laura Malave at malave.laura@spcollege.edu or Club President Michael Milford at mmilfo1@live.spcollege.edu.
Join the Club: https://tinyurl.com/CyFor
Interested in studying Cybersecurity?
St. Petersburg College offers both a Certificate and Associate of Science in Cybersecurity. These programs will prepare you to meet the growing need for college-educated specialists who can tackle increasingly complex information technology security concerns.
SPC CTF Team Titans Get 3rd Place Finish at Raymond James Capture the Flag 2017
April 27, 2017 Technology EventsLaura Malave
The SPC CTF Team Titans took home a third-place finish in their first Raymond James Capture the Flag 2017 information security competition in April.
Student competitors William Wantling, Michael Milford, James Austin, and Jason Crochunis, along with faculty mentor Laura Malave, participated in the CTF competition held at the Raymond James International Headquarters in St. Petersburg.
This was the first CTF competition for the SPC CTF Team Titans and outstanding work by the students who prepared in less than a month.
Team Titans, I am so very proud of your work at the Raymond James Capture the Flag. Congratulations on a fantastic performance at your first CTF. I look forward to working with you in the future.
Other colleges and universities and colleges that took part included the University of Central Florida, the University of South Florida, the University of Florida, the University of North Florida, the University of Tampa, Penn State University, and St. Leo University.
#spcollege Congratulations Team Titans 3rd place finish at the #RaymondJamesCTF Capture the Flag 2017 pic.twitter.com/BoYWgvtZXh
— Susan Biszewski-Eber (@SusanBiszewskiE) April 24, 2017
The Raymond James CTF was designed to the strengthen the talent pipeline between Raymond James and universities and colleges. CTF challenges were designed to expose students to the types of challenges faced in the financial services industry and to identify talent for potential internship opportunities in the Raymond James Information Security and Infrastructure organization.
The winning team, UCF's Knightsec, received a $10,000 cash prize, that was evenly distributed among the students.
I would like to thank CCIT cybersecurity adjunct instructor Ryan Irving for serving as a faculty mentor to Team Titan," Malave said. "Thank you to Charleston Fritts for assistance with the logistical coordination for the event. Also, thank you to Susan Biszewski-Eber, Lenore Swaim, Dawn Ellis, Judy Steeg, and Jamaal White for helping to get the SPC polos to the Team Titan members. SPC faculty members and adjunct instructors that participated in the Titan Teams planning meetings included: Adrian Tillman, Brad Yourth, Thomas Ma, Ryan Irving, and Catherine Davis.
#raymondjamesCTF
See more tweets from the event at #raymondjamesCTF.
Technology scholarships for high school students
September 23, 2016 College of Computer and Information Technology, Cybersecurity, Technology ScholarshipsLaura Malave
Looking for technology scholarships for college?
The Tampa Bay Chapter of the ISC(2), (International Information System Security Certification Consortium) is awarding two $1,000 scholarships to local high school juniors and seniors. ISC(2) is a non-profit organization which specializes in information security education and certifications.
You may be eligible for these technology scholarships. High School juniors and seniors with a minimum 3.0 GPA and interest in majoring in an Information Technology discipline should apply for these technology scholarships to help pay for their college education.
How to apply for technology scholarships
Apply online for these technology scholarships before Oct. 31.
ISC(2) Tampa Bay Chapter
Student membership is $10
View the ISC(2) events calendar
Other technology scholarships at St. Petersburg College
Through a federal grant, St. Petersburg College has awarded academically talented and financially disadvantaged students up to $6,500 in scholarships to help them pursue degrees in STEM – science, technology, engineering and math. SPC also offers $1,500 in Smart Choice and Tech Data scholarships. Business Technology Program scholarships and Technology Management scholarships are offered as well.
The St. Petersburg College Foundation provides hundreds of scholarships to SPC students. Funds are provided by private gifts from generous individuals, community groups and businesses. Learn more about SPC Foundation Scholarships.
Technology degrees at SPC
If you are a Pinellas County high school junior or senior looking to prepare for a career in Technology, St. Petersburg College may be a good fit for you.
All our information technology A.S. degrees transfer to our Technology Development and Management B.A.S. Degree.
St. Petersburg College technology degrees and certificates include:
Technology Development and Management B.A.S. Degree
Computer Information Technology A.S. Degree
Help Desk Support Specialist Certificate
Cybersecurity A.S. Degree
Cybersecurity Certificate
Computer Networking A.S. Degree
Computer Support Certificate
Cisco Certified Network Associate Certificate
Linux System Administrator Certificate
Microsoft Certified Solutions Associate
Computer Programming and Analysis A.S. Degree
Computer Programmer Certificate
Computer Programming Specialist Certificate
Web Development A.S. Degree
Web Development Certificate
Hacksummit hosts virtual conference
February 18, 2016 College of Computer and Information Technology, expoLaura Malave
Hacksummit will be hosting a Virtual Developer/Programming Conference in February. Free of charge, the event will feature:
Lectures from creators of programming language
Contributors to Open Source
Hacksummit is unique because out of all virtual conferences, it is the largest. It is also known for being the largest type of programming conference of all time as well as the largest hackathon. The best part is you can stay at home and participate.
This is just one of many technology events that has been featured that is geared toward IT professionals and those who have an interest in information technology. In the past year, The (ISC)2 Tampa Bay Technology Chapter hosted several quarterly meeting in 2015. Courtesy of the Tampa Bay Technology Forum (TBTF), Valpak hosted a facility tour. St. Petersburg College (SPC) students also had the opportunity to attend exploratory labs and career fairs.
Hacksummit Virtual Conference
February 22nd-24th 2016
Women in Tech comes to Startup Week
February 4, 2016 College of Computer and Information Technology, entrepreneurshipLaura Malave
Women in Tech is just one event that will be featured at Tampa Bay StartUp Week. Since StartUp Week is a five-day celebration of your community, all are encouraged to join in this new type of conference that builds momentum and opportunity to become an entrepreneur. This event is led by entrepreneurs and hosted in the entrepreneurial spaces you love. Startup Week is a reflection of your hard work and your community's unique entrepreneurial identity.
Thursday Feb. 11
Come prepared to:
Share your aspirations, concerns and ideas for strengthening this particular part of our community
Gain a better understanding and awareness of the desires, needs and challenges of women working in technology careers that will lead to positive change and growth in Tampa Bay
Help identify shared goals and concerns and possibilities for resource sharing, connections and collaboration.
The event is open to the public and will be facilitated by the Tampa-Hillsborough County Public Library. Visitor parking is free of charge and is available in the Thomas Garage on the first floor. Lowth Center is on the 8th floor.
Technology Chapter hosts quarterly meeting
January 26, 2016 CybersecurityLaura Malave
It's that time again for the (ISC)2 Tampa Bay Technology Chapter to host another quarterly meeting. As mentioned in a previous article, the (ISC)2 Tampa Bay Chapter is a registered 501 (c)3 organization which provides its members with a networking opportunity to share knowledge, exchange resources and collaborate on projects. This forum allows members to have the ability to gain a sense of fellowship with colleagues in their profession. They will also be able to network and exchange ideas with fellow (ISC)2 credential holders and other information security professionals within the West-Central Florida area.
Academic Department Chair Laura Malave, of St. Petersburg College's College of Computer & Information Technology (CCIT) attends these quarterly meetings. Since she teaches IT Security courses for CCIT, these meetings provide an excellent opportunity to keep abreast of industry trends, network with industry professionals and collaborate on projects. As part of her involvement with the Tampa Bay Chapter, Malave volunteers her time as a planning committee member for the Tampa BSides Information Security Conference. Involvement with organizations such as this help professors such as Malave bring real world experience to the classroom.
The next quarterly event will be held on:
4401 Himes Avenue, #175
Valpak hosts facility tour for TBTF
January 22, 2016 College of Computer and Information Technology, Technology EventsLaura Malave
Please join the staff, board and members of the Tampa Bay Technology Forum (TBTF) for an evening of networking, learn about our membership and our host organization, and get a tour of the Valpak facility. The first quarter will be hosted by Valpak Chair, Chris Cate.
Valpak event details
Learn more about the event at http://tbtf.org/event/tbtf-member-forum/
You can look forward to:
Meeting TBTF's 2016 Chair Chris Cate
Touring Valpak's world class manufacturing facility
Connecting with the team known for their Agile Transformation
Learn more about what TBTF has planned for 2016
Get the inside scoop on our upcoming Career Fair on March 25
This event will be held on:
Thursday, January 28, 5:30 – 7 p.m.
at ValPak, 805 Executive Center Dr. W., St. Petersburg, FL 33702.
Career Fair comes to TBTF on March 25
January 20, 2016 College of Computer and Information Technology, expoLaura Malave
It's that time again for the Tampa Bay Technology Forum (TBTF) Career Fair. The Career Fair will continue to encourage participation from hiring managers and senior leadership as we expand with tracks for students and veterans and open our doors to all job seekers at large at no cost.
Learn more about how St. Petersburg College can prepare you for technology careers at www.spcollege.edu/ccit.
Technology career fair details
Friday, March 25, 9 a. m. – 1 p. m.
Tampa Convention Center
333 S. Franklin St.
St. Petersburg College maintains industry centered curriculum
September 16, 2015 Certifications, College of Computer and Information Technology, CybersecurityLaura Malave
With rapid changes in the IT industry, it is vital that colleges and universities maintain industry centered curriculum standards. To ensure that this is the case, professors from St. Petersburg College's College of Computer & Information Technology (CCIT) attend conferences regarding its programs.
Laura Malave, Academic Department Chair, attended the IT A.S. Program Review Committee meeting at Valencia College in Orlando, on July 16-17 to review the IT Security, Technology Management, and Network Systems Technology Associate in Science Degrees.
Industry centered curriculum builds skills for IT careers
The purpose of this review was to ensure that the programs are aligned with the needs of business and industry. To make sure we maintain industry centered curriculum, programs need to include performance standards that lead students towards the career, academic and workplace skills needed for employment and success in the Information Technology industry. This is accomplished with the help of partners in education, business and industry, and trade associations.
Faculty from throughout the state of Florida attended the program review bringing recommendations from their colleges and local industry representatives.
For the purposes of SPC's IT Security certificate, SPC endeavors to help students prepare for and pass the CompTIA Security+ Certification.
Get more information or request details about SPC's many information technology programs
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Load your family into the 2019 Volvo XC40. A turbocharger is also included as an economical means of increasing performance. Volvo prioritized fit and finish as evidenced by: a leather steering wheel, a blind spot monitoring system, a power liftgate, lane departure warning, remote keyless entry, a roof rack, and 1-touch window functionality. Volvo ensures the safety and security of its passengers with equipment such as: dual front impact airbags with occupant sensing airbag, front side impact airbags, traction control, brake assist, anti-whiplash front head restraints, a panic alarm, an emergency communication system, and 4 wheel disc brakes with ABS. You'll never lose visibility with rain sensing wipers, which activate automatically when the drops start to fall. We pride ourselves in consistently exceeding our customer's expectations. Stop by our dealership or give us a call for more information.


The New Year has barely rolled in and already Mother Nature has shown her strength. Just this last month, our part of the world has experienced such soul-rattling loss. We shake our heads at the cruel timing of these tragedies: Christmas—when all should be happy, festive, peaceful and bright. Should it?
When I think of all my Christmases as an adult, I can't say that the feeling of joy stands out. In fact, it is almost the opposite. My Christmases have always been tinged with heaviness, some sadness and definitely a lot of inwardness. It is always a time of inner struggle—especially since becoming a mother—to awaken and understand that TRUE "Christmas Spirit" and carry it within me for my children to experience.
I have been reading up on Christian Festivals and discovered that this element of darkness during Christmas helps us to find the spiritual light within. The Christ light. It is through this background that I try to understand every inner and outer calamity that touches the world this time of year.
The end of every year is never easy. The minute you whip out your Christmas list, your whole life flashes before you. What do you give this person? Where is she in your life today? Where were you in relation to another the year before? The very season is structured for reflection and inwardness, hence the difficulty. Every Christmas is a review of a year of living and the experience isn't always pleasant. But it is through this process, if done with care and consciousness, that the true spirit of the season can shine.
When the New Year rolls in, the deep darkness of the Christmas season slowly begins to lift. What burrowed deep into the earth the last few months slowly rises up to the surface, preparing to bloom and meet the sun upon its return. In this spirit, we ask ourselves, "What in me needs to awaken?" I believe this is the deeper root of New Year's resolutions that, over time and through the ravages of materialism, have been so diluted to pie-slice proclamations: I will stop smoking, eat no meat, shun rice, lie less. This year, perhaps, we can shift our focus to soul qualities. What there needs to be strengthened, fortified, coaxed through?
I have spent the last few years in turbulent introspection. As I inch my way towards peace, I realize that all this is for nothing if I am unable to make my experiences matter in the world. What from my inner depths can I offer my community? As if on cue, I was presented with the opportunity through the Karangalan Conference and Festival, which is a 3-day event (January 21-23, 2005) aimed at celebrating everything good and true about the Filipino. It is a wonderful way to start 2005. What better way to meet the year than to focus on the positive and direct one's brightest intentions and energies toward a country that so needs to be brought back on its feet again? If we were all to take that intention, turn it into conviction and deed, then offer it back out into the world, wouldn't that be SOMETHING? I think it would be phenomenal, and so I choose to start my year by offering my inner light to shape a vision of a better Philippines.
As I write this, my heart is full with the sight and sounds of my boys frolicking on the beach while, not that far away, families like my own perished hours ago. It could have easily been us. But we are here. It is very difficult now not to make our lives matter. Not just for ourselves, but for others.
It is a New Year and already we are reminded of the weight of life. It is very clear that your life isn't just about you. Dust off your scale and decide how to make your life matter in the world. Take your light and make it shine through. Do it where you are. There is no time to lose.


Lan Acre, a renegade fighter who operates between the law, fighting intergalactic criminals with Anti-factor and stealing valuable and high tech things from said criminals. Until one day, buildings were being sliced and blasted by an unknown green hooded figure. Lan responded hoping to get a huge reward for beating him but he outran her attacks and escaped leaving her at the center of the destruction surrounded by Anti-factor.
Hello everyone! Today marks the 3rd anniversary of PLANET ACE!
As you know, PA! has been on hiatus for a while and I greatly apologize is taking so long. I been busy with a lot of things and is given me difficult time to focus on the comic. And I hope that I can get back to it soon, I appreciate everyone for being patience and continuous support. Again, Thank you!
amazing!!! i love it so far!! i can't wait to see what this story holds! i love space stories!!
CHAPTER 3 END! Thank you everyone for reading this far!
PLANET ACE! will be on hiatus until further notice for the next chapter.
In the meantime, I'm happy to announce there's PLANET ACE! discord server! In which you can chat with fans of this comic & including the creator, me!
So was that a type of answer the he that they knew would've given?
this is great ,love the artstyle! she actually looks kind of like hatsune miku xD or... maybe that's my Otaku speaking, just started reading! can't wait to see whats next!
Agreed, that is a very appropriate response!


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Program Assistant At Kids in Need of Defense
Contract United States of America July 6, 2021 Program/Project Management
About KIND:
Kids in Need of Defense (KIND) is a global leader in the protection of unaccompanied refugee and migrant children. Launched in 2008, KIND champions a world in which every child's rights and well-being are protected throughout their journey to safety. Since 2008, KIND has accepted over 23,000 referrals of children seeking legal representation in their immigration proceedings. KIND has welcomed more than 41,000 attendees to trainings since its founding, cultivating partnerships with over 670 law firms, corporate legal departments, law schools, and bar associations across the country.
KIND's social services program ensures that migrant and refugee children – who have often endured trauma – receive counseling, educational support, medical care and other comprehensive services.
To address the root causes of child migration from Central America and strengthen protection of unaccompanied children, KIND advocates for policy changes and educates lawmakers, the media, and the broader public on the conditions that drive these children to flee their home countries. KIND supports children returning to their home countries by connecting them to essential support services and sponsors gender-based violence prevention programs in Central America to protect children in countries of origin and transit.
KIND is also building upon its expertise in the protection of unaccompanied children to encourage the development of pro bono initiatives across Europe in partnership with European NGOs.
KIND seeks a Program Assistant to accept case referrals, conduct comprehensive intakes and outreach to child clients, manage data entry, prepare a comprehensive set of case documentation, and to be responsible for the overall administrative duties of the office, including database management.
Liaise with colleagues at other nonprofits, as well as individual members of the public, to receive on-line or telephonic referrals and ensure that referrals comply with KIND's case acceptance criteria.
Schedule and manage all logistics to ensure that an intake interview is timely scheduled.
Interview, screen and conduct a comprehensive intake with each individual child.
Prepare a case summary and comprehensive memorandum for each intake, and assemble a set of case documents for use by the KIND Staff and Pro Bono Attorneys.
Prepare and manage docket lists for upcoming court dates as well as assist and notify children who are still waiting for placement with counsel.
Assist with office administration and operations, case management, and data entry.
*Fluency in Spanish required.
Experience working with children, preferably immigrant and refugee children, or experience working with survivors of abuse, human trafficking, or other trauma.
Experience conducting intakes.
Experience with office organization and management, particularly in legal settings.
A strong record of cultural competence and cross-cultural communication skills.
Ability to work collaboratively, and preferably, prior experience working with attorneys, law firms, or other legal service providers.
Experience in data management.
Excellent organizational skills and attention to detail.
Experience or familiarity with immigration and/or family law and immigration authorities.
Salary Range: $38,148-$47,736 dependent on experience
Please be advised that an employment application will need to be submitted along with your resume and cover letter, in order to be considered for the desired role.
KIND has an organization-wide commitment to diversity, equity and inclusion. We strive to create a work environment where everyone has a sense of belonging. Individuals from historically underrepresented or underserved communities are strongly encouraged to apply.
Please apply directly on our site with this link: https://supportkind.hrmdirect.com/employment/job-opening.php?req=1626174&cust_sort1=100304&&jbsrc=1025
ngo job ngo jobs worldngojobs.com
ABA ROLI Europe & Eurasia-Program Associate at American Bar Association
Contract United States of America December 8, 2021
HR Assistant – Manila (Filipino Nationals Only) at Action Against Hunger USA
Specialist II – Talent Acquisition- (US Only) at Catholic Relief Services
Senior Technical Program Manager at GiveDirectly
New Business Manager at Panagora Group
USA Senior Team Lead (PMT) at Macfadden


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LATEST DB4C NEWS:
Doncaster Business for the Community raise thousands to save children's lives!
Annual cricket challenge announced
Celebrations as the Business All-Stars lift the cup
Doncaster Business Community Vase Sunday 8th September
The Diamond Ball at Bawtry Hall Saturday 28th September
DB4C to light up its fundraising for the second year running
Meet the Business All-Stars 2019
Meet the Commercial Legends 2019
DB4C News
DB4C Events
The 2019 DB4C Business Community Cup will take place on Friday 31st May at The Keepmoat Stadium and will once again be played under floodlights with an early evening kick-off of 6.45pm
Last year saw the first such event as the two teams, The Business All Stars and The Commercial Legends, competed for the trophy with players drawn from businesses across Doncaster and watched by hundreds of supporters.
In a new and exciting development the teams will be managed by two former Doncaster Rovers legends, Tim Ryan and Jan Budtz, and will involve two squads of 18 players who will contest the Cup over 90 minutes with penalties being the decider should the scores be level at full time.
Each player has enjoyed a truly professional footballer experience from training, under the guidance of coaches from Doncaster Rovers FC, which started at the end of February, to a unique transfer window through to a pre-match training game to be held at Doncaster Rovers Cantley Training Ground.
This year is also more than just a game for fans, with entertainment for the family with chance to Meet Donny Dog, a kids penalty shoot competition and also live music from local indie rock and roll band "The Outcharms" will be playing a setlist before kick off on the pitch.
After releasing latest single "Talk" they have thousands of monthly listeners and regular sell out venues wherever they play. When asked to be involved a spokesman for the band said, "It's an honour to be able to support the Doncaster Business Community Cup and its associated charities."
"Last year's Doncaster Business Community Cup was a great success, hosted under the floodlights at Club Doncaster for the first time ever. We are delighted to again work in partnership with DB4C and to be able to offer the opportunity for local employers to support community causes by entering players into the match."
SHANE Lockwood, group head of marketing and communications at Club Doncaster
DB4C Director and Trustee, Anthony Temperton added:
"This is a truly great event and a great partnership with Doncaster Rovers FC and Club Doncaster Foundation. Those who sign up will have the opportunity of playing in a competitive match at the stadium, being coached and managed by former football professionals and doing their bit for charity in the local community."
"At DB4C we are not just about supporting local causes and charities, we are also about improving the health and wellbeing of business employers and their staff throughout the Doncaster area and this is an excellent example of our work."
"Sponsorships and players spaces sold out very quickly this year and ticket sales have increased compared to last year. Proceeds this year going to the Doncaster Disabled Peoples Alliance and the Childrens Air Aumbalance based out of Doncaster Sheffield Airport."
There are lots of ways that you can support us. We're a charity and we couldn't continue our work without your help. Get Involved with our 2020 Business Community Cup. Email for details or
DB4C Instagram
Doncaster Business for the Community is a registered charity in England and Wales (1179872)


This triple bill from Birmingham Royal Ballet began with Arcadia, a new work from company dancer Ruth Brill, continued with Michael Corder's take on Le baiser de la fée, and concluded with David Bintley's Still life at the Penguin Café, a work whose title has intrigued me for years, although this was my first opportunity to see it.
Arcadia told a story about the god Pan, half human, half animal, and his relations with those who share his world, both his fellow supernatural beings and his human subjects. The work opened beautifully thanks to atmospheric lighting by Peter Teigen, which shrouded a semi-crouching Pan in a mysterious haze. There was some nice, if not world-shattering choreography, especially for Pan who was danced by Brandon Lawrence. He leaped and bounded, and stretched his body as he swept his arms in all directions. But had I not read the program notes I would never have guessed that we were meant to be watching Pan in two moods, frustrated at first and then at peace with himself after the intervention of Selene, goddess of the moon. Perhaps the music, a composition by John Harle originally for violin, piano and soprano saxophone and specially orchestrated for this ballet, was partly the problem. While it was jazzy and made great listening, there didn't seem to be enough variation in musical mood for Pan's change of mood to be felt. But it was not helped by the fact that choreographically and dramaturgically that mood change didn't happen. The dancers just danced on as if nothing had happened.
On the other hand, I thought Corder's Baiser de la fée, danced to the Stravinsky score and based on Hans Christian Andersen's The ice maiden, was beautifully structured so the story unfolded clearly and strongly, even given the complexities of the storyline. True, it was quite classical in format—it even had a form of grand pas de deux in the second scene when the Young Man (Lachlan Monaghan), whose fate was sealed when he was kissed as a baby by the Fairy (Jenna Roberts), dances with the bride as she prepares for the nuptials. For some that grand pas might make the work a little old-fashioned, but I loved the clarity of the piece and the way it moved inexorably to the finale when the Fairy claims the Young Man. And the designs by John F. Macfarlane were stunning in their decorative elements and in their use of colour to heighten both mood and the nature of the various characters.
I was fascinated by Still life at the Penguin Café. It dates back to 1988 but its theme of issues surrounding endangered species is still as valid as it was back then. Is there still life for some species who today teeter on the brink of extinction, or are they still life as we understand a still life painting? However we may interpret that title (and there is room for both), Still life at the Penguin Café is a remarkable series of sketches, each one referring to a different species at risk, mostly hilarious on the surface, and always delightfully costumed (design by Hayden Griffin). I guess while the issue of endangered species is not to be mocked, there is room, as Bintley has done, to bring it to our attention in a light-hearted, episodic way. Full marks to the dancers who grabbed the opportunity to display their skills with special mention to Edivaldo Souza da Silva as the Southern Cape Zebra, not to mention those delightful penguin waiters.
I am a big fan of triple bill programs. But it is rare to get a triple bill where every work delivers what media releases tell us it will be like. This program wasn't an example of such rarity but there was a lot to enjoy.