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Alonzo, Carolina (A.A. 2021/2022) Decentralized autonomous organization: is it the corporate future? Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 52. [Bachelor's Degree Thesis]
Bacci, Giulio (A.A. 2021/2022) Corporate purpose, ESG, and the debate on capitalism in the US. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 49. [Bachelor's Degree Thesis]
Bonomo, Giulia (A.A. 2021/2022) In the shadow of social bias: the importance of gender diversity in the boardroom for a strategic change. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 68. [Bachelor's Degree Thesis]
Bologni, Francesco (A.A. 2017/2018) Merits and shortcomings of the proxy advisory industry: a critical analysis of the EU regulatory framework. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), LUISS Guido Carli, relatore Sabrina Bruno, pp. 51. [Bachelor's Degree Thesis]
Capelli, Martina (A.A. 2021/2022) Proxy season and voting trends in the US. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 40. [Bachelor's Degree Thesis]
Coiro, Eloisa (A.A. 2020/2021) Virtual assets' regulation in the United States: SEC v. Ripple, the cryptocurrency trial of the century. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 95. [Bachelor's Degree Thesis]
Corbello, Francesca (A.A. 2020/2021) Directors' duties and liabilities across Italy, UK and USA. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Sabrina Bruno, pp. 51. [Bachelor's Degree Thesis]
Corsi, Francesco (A.A. 2020/2021) From clubs to corporations: a study on how economics changed the sport industry. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Francesca Vicentini, pp. 50. [Bachelor's Degree Thesis]
Core, Edoardo (A.A. 2020/2021) Corwin illusion: rebalancing M&A litigation. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 54. [Bachelor's Degree Thesis]
Campagna, Alessio (A.A. 2017/2018) Companies in Japan: domestic and gaikokujin establishment. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), LUISS Guido Carli, relatore Sabrina Bruno, pp. 118. [Bachelor's Degree Thesis]
De Marcis, Riccardo (A.A. 2021/2022) Past, present and future of poison pills. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 70. [Bachelor's Degree Thesis]
Di Bartolo, Michele (A.A. 2020/2021) The debate on corporate purpose. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 49. [Bachelor's Degree Thesis]
De Windisch Graetz, Niccolò (A.A. 2020/2021) The demand on directors in derivative actions and the futility regime. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 42. [Bachelor's Degree Thesis]
Diotallevi, Ginevra (A.A. 2018/2019) Share buyback: legal and economic rationale comparing EU and US legislation and practice. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Sabrina Bruno, pp. 76. [Bachelor's Degree Thesis]
Esposito, Chiara (A.A. 2021/2022) ESG: corporations towards social and environmental change? Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 51. [Bachelor's Degree Thesis]
Fusco, Francesca (A.A. 2020/2021) M&A in the luxury indutry: a growing pattern. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 56. [Bachelor's Degree Thesis]
Fransoni, Maria Adelaide Giovanna (A.A. 2020/2021) Abuse of majority: a comparison between Italian and English corporate law. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Sabrina Bruno, pp. 49. [Bachelor's Degree Thesis]
Ferrarese, Rebecca (A.A. 2017/2018) Mergers and acquisitions: factors of failure. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), LUISS Guido Carli, relatore Sabrina Bruno, pp. 53. [Bachelor's Degree Thesis]
Guglielmini, Marco (A.A. 2021/2022) Prospective regulation of digital assets in the United States. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 46. [Bachelor's Degree Thesis]
Gianni, Diletta (A.A. 2021/2022) Economic inequalities: the role of corporate governance and public pension funds. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 63. [Bachelor's Degree Thesis]
Garzini, Matteo (A.A. 2020/2021) Private ordering solutions for excessive shareholder litigation: the impact of boilermakers, ATP Tour and Sciabacucchi. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 51. [Bachelor's Degree Thesis]
Grandoni, Tommaso (A.A. 2020/2021) Crisis pills: the adoption of poison pills in response to the Covid-19 economic crisis. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 62. [Bachelor's Degree Thesis]
Grasso, Arianna (A.A. 2020/2021) Legal strategies to address capitalism inequalities. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 40. [Bachelor's Degree Thesis]
Giacchè, Carlotta (A.A. 2018/2019) The European banking Union and its impact on the solution to the Italian banking crisis. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Laura Segni, pp. 50. [Bachelor's Degree Thesis]
Giacomelli, Lorenzo (A.A. 2017/2018) Legal and economic aspects of financial fair play. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), LUISS Guido Carli, relatore Sabrina Bruno, pp. 40. [Bachelor's Degree Thesis]
Greco, Elisa (A.A. 2017/2018) Shareholders' remedies: the derivative action in the UK, the USA and Italy. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), LUISS Guido Carli, relatore Sabrina Bruno, pp. 44. [Bachelor's Degree Thesis]
Journo, Jacopo (A.A. 2018/2019) Brexit: an analysis from its roots to future consequences. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Laura Segni, pp. 36. [Bachelor's Degree Thesis]
Loccisano, Giuilia (A.A. 2021/2022) Start-up legislation in US, UK, and Italy: a comparison between the three jurisdictions. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Sabrina Bruno, pp. 51. [Bachelor's Degree Thesis]
Laureti, Carolina (A.A. 2021/2022) The interaction between sustainability and competition policy. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Gianluca Faella, pp. 73. [Bachelor's Degree Thesis]
Lupi, Giacomo (A.A. 2020/2021) Capitalism inequalities and corporate purpose: illusion or turning point? Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 75. [Bachelor's Degree Thesis]
Lemassel, Mohamed-Manil (A.A. 2019/2020) Regulations of financial institutions in the US/UK. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Sabrina Bruno, pp. 47. [Bachelor's Degree Thesis]
Michieletto, Pietro (A.A. 2021/2022) Competition law in the sports industry: the European Super League case. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Gianluca Faella, pp. 63. [Bachelor's Degree Thesis]
Morici, Giacomo (A.A. 2021/2022) SG: from shareholderism to stakeholderism? Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 61. [Bachelor's Degree Thesis]
Mainardi, Caterina (A.A. 2021/2022) An overview of blockchain application in the financial and legal sector: a regulatory riddle. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 45. [Bachelor's Degree Thesis]
Marzullo, Camilla (A.A. 2020/2021) Gender diversity in boardrooms. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 64. [Bachelor's Degree Thesis]
Morera, Ludovico (A.A. 2019/2020) The direct listing as a competitor of the traditional IPO. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 65. [Bachelor's Degree Thesis]
Mazzitelli, Riccardo (A.A. 2018/2019) The effects of ownership concentration: assesing a relation. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Sabrina Bruno, pp. 68. [Bachelor's Degree Thesis]
Meneghello, Diletta (A.A. 2018/2019) The legal framework behind the non-financial statement: an insight into the Brunello Cucinelli case. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Sabrina Bruno, pp. 48. [Bachelor's Degree Thesis]
Muscolo, Noemi (A.A. 2017/2018) Shareholders empowerment: US and UK in comparison. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), LUISS Guido Carli, relatore Sabrina Bruno, pp. 48. [Bachelor's Degree Thesis]
Nicifero, Federico (A.A. 2021/2022) Regulation digital assets in the US. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 47. [Bachelor's Degree Thesis]
Napolitano, Allegra (A.A. 2021/2022) A retrospective analysis of the Williams case and possible best practices for the future. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 43. [Bachelor's Degree Thesis]
Pirela Borrero, Jose Ignacio (A.A. 2021/2022) The Corwin doctrine. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 48. [Bachelor's Degree Thesis]
Parisi, Anna Clara Grace (A.A. 2021/2022) Robots in the boardroom: incentivizing the optimal use of artificial intelligence by corporate directors. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 40. [Bachelor's Degree Thesis]
Pola, Arianna Odile (A.A. 2021/2022) Diversity in corporate boardrooms. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 65. [Bachelor's Degree Thesis]
Pezzuto, Vittoria (A.A. 2020/2021) Artificial intelligence, blockchain and tech companies in the United States: innovation, legislation, issues. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 48. [Bachelor's Degree Thesis]
Pelillo, Marco (A.A. 2020/2021) Undocumented business: the application of oral contracts and the matter of implied partnerships under US law. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Sabrina Bruno, pp. 51. [Bachelor's Degree Thesis]
Poiatti, Federico (A.A. 2020/2021) Takeovers and defensive tactics: poison pills in the wake of pandemic crisis. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 59. [Bachelor's Degree Thesis]
Piano, Umberto (A.A. 2020/2021) The big three and sovereign wealth funds: from Berle and Means to the new blockholders. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 58. [Bachelor's Degree Thesis]
Piscitelli, Antonio (A.A. 2019/2020) Implementing DLTs in listed companies: shareholders' identification. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 28. [Bachelor's Degree Thesis]
Pezzotti, Guido (A.A. 2018/2019) Can antitrust keep up with innovation? Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Laura Segni, pp. 27. [Bachelor's Degree Thesis]
Regolo, Eugenio (A.A. 2021/2022) Beyond shareholders primacy: debate on corporate purpose and ESG. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 59. [Bachelor's Degree Thesis]
Rossetti, Tommaso Luca (A.A. 2020/2021) Musae: will a digital solution meet the changing needs of cultural sites? Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore "Jose" D'Alessandro Giuseppe, pp. 72. [Bachelor's Degree Thesis]
Russo, Lorenzo Maria (A.A. 2020/2021) The Darwinism of private ordering: effectiveness and efficiency. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Pierluigi Matera, pp. 51. [Bachelor's Degree Thesis]
Regalbuto, Ilaria (A.A. 2020/2021) On the relationship between big data, privacy and antitrust regulation: the Facebook case. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Gianluca Faella, pp. 74. [Bachelor's Degree Thesis]
Ramazio, Emanuele (A.A. 2018/2019) The crumbling banking system: analysis of the technological impact within the retail sector. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Laura Segni, pp. 43. [Bachelor's Degree Thesis]
Scialpi, Elena (A.A. 2021/2022) Strategic data, unilateral exclusionary conduct, and the enforcement of article 102 TFEU in the Italian energy market: the Enel case. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Gianluca Faella, pp. 56. [Bachelor's Degree Thesis]
Sha'at, Reem Mahmoud Musallam (A.A. 2019/2020) Capital inflows & economic growth: exploring the differences in impact of capital inflows on developing transition and developed economies. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Mirella Pellegrini, pp. 32. [Bachelor's Degree Thesis]
Tavani, Allegra (A.A. 2020/2021) The anticompetitive conduct for the monopoly of display advertising and search advertising: the case of Google LLC. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Sabrina Bruno, pp. 61. [Bachelor's Degree Thesis]
Traietti, Francesco (A.A. 2018/2019) USA and China: possible consequences on the global economy. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Laura Segni, pp. 33. [Bachelor's Degree Thesis]
Vicari, Flavia (A.A. 2020/2021) Cryptocurrencies vs regulations: an analysis of legal challenges and future perspectives. Tesi di Laurea in Law and economics (corporate and business law: antitrust and regulation), Luiss Guido Carli, relatore Sabrina Bruno, pp. 64. [Bachelor's Degree Thesis]


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William Van Alen (10 d'agost de 1883-24 de maig de 1954) va ser un arquitecte nord-americà, conegut especialment pel disseny de l'edifici Chrysler (1929) de Nova York.

Biografia
William Van Alen va néixer al barri de Brooklyn, a Nova York, l'any 1883. Va cursar estudis al Pratt Institute del seu barri natal i en els seus començaments va treballar a l'estudi de l'arquitecte Clarence True. També va estudiar durant tres anys a l'estudi de l'arquitecte francoamericà Emmanuel Louis Masqueray.

A l'acabar els seus estudis, Van Alen va treballar per diverses firmes a Nova York, sobretot en el projecte de l'hotel Astor per Clinton & Russell (1902), abans de rebre la beca del Premi París el 1908.
La beca el va portar a estudiar a París amb Victor Laloux, un dels arquitectes europeus més destacats de la Belle époque, a l'Escola de Belles Arts de París.

Quan Van Alen va tornar a Nova York el 1910, ja s'havia interessat pels nous estils arquitectònics, inclòs el modernisme pel qual més tard es va donar a conèixer. El 1911 va formar una associació amb H. Craig Severance, un altre arquitecte amb interessos professionals similars però amb un estil personal molt diferent. Severance era gregari i encantador, mentre que Van Alen era més introvertit. L'associació va prosperar i es va fer coneguda per les seves distintives estructures comercials de diversos pisos. Va completar un edifici el 1914 al Lower Manhattan, que va destacar per tenir aparadors a ras de les parets en lloc de recular, una innovació que després es va convertir en una pràctica estàndard. A la dècada de 1920, Severance i Van Alen van començar a rebre encàrrecs més importants, però la seva relació es va refredar a causa de les seves diferències personals, i l'associació es va dissoldre el 1924.

Ja en solitari, Van Allen va dissenyar l'edifici Chrysler, gratacels considerat la icona arquitectònica de l' art déco. Van Alen no va signar cap contracte amb Walter Chrysler quan va rebre l'encàrrec de l'edifici Chrysler. Un cop acabades les obres, Van Alen va sol·licitar el pagament del 6% del pressupost de construcció de l'edifici (14 milions de dòlars), una xifra que era la tarifa habitual de l'època. Després que Chrysler rebutgés el pagament, Van Alen el va demandar, va guanyar el judici i finalment va rebre els honoraris. La demanda va depreciar significativament la seva reputació com a arquitecte contractable. Després que la seva carrera fos efectivament arruïnada per això i agreujada amb la Gran Depressió, Van Alen va centrar la seva atenció en ensenyar escultura.

Referències

Enllaços externs
 Van Alen Institute

 V
Persones de Brooklyn
Alumnes de l'Institut Pratt
Morts a Nova York
Artistes novaiorquesos

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Abhay Moghekar, M.B.B.S.
Abhay Rajeshwar Moghekar, M.B.B.S.
Research Director, Cerebrospinal Fluid Center, Department of Neurology
Associate Professor of Neurology
Languages: English, Hindi, Marathi
Alzheimer's Disease (AD), Cerebrospinal Fluid (CSF) Leaks, CSF Otorrhea, CSF Rhinorrhea, Dementia, Intracranial Hypertension, Neurology, Normal Pressure Hydrocephalus, Pseudotumor Cerebri, Spontaneous Intracranial Hypotension, Venous Sinus Stenosis ...read more
Disorders of Cerebrospinal Fluid
Normal Pressure Hydrocephalus: Patricia's Story
Johns Hopkins Bayview Medical Center
301 Mason Lord Drive
The Johns Hopkins Hospital
Phipps Suite 126
Dr. Abhay Moghekar focuses on disorders of cerebrospinal fluid physiology like normal pressure hydrocephalus, obstructive hydrocephalus, congenital hydrocephalus, pseudotumor cerebri, CSF otorhhea, CSF rhinorrhea, intracranial hypotension due to spinal CSF leaks and peri-operative management of patients undergoing repair of CSF otorrhea and rhinorrhea.
His research interests include identifying biomarkers of neurodegenerative disorders including Alzheimer's disease and Normal Pressure Hydrocephalus.
Associate Professor of Neurosurgery
Associate Professor of Otolaryngology - Head and Neck Surgery
Cerebrospinal Fluid Disorders, Center for
Memory and Alzheimer's Disease Treatment Center
Normal Pressure Hydrocephalus Center
MBBS, Lokmanya Tilak Municipal Medical College (1996)
King Edward Memorial Hospital / Internal Medicine (1998)
MedStar Harbor Hospital Center / Internal Medicine (2000)
Johns Hopkins University School of Medicine / Neurology (2003)
Johns Hopkins University School of Medicine / Clinical Neurophysiology (2004)
American Board of Psychiatry And Neurology / Neurology (2005)
Dr. Abhay Moghekar's research interests focus on understanding the causes of normal pressure hydrocephalus, pseudotumor cerebri, intracranial pressure dynamics and the role of cerebrospinal fluid in Alzheimer's disease.
Patient Video: Pseudotumor Cerebri - Ashley's Story
Recorded Webinar "Pseudotumor Cerebri: What You Need to Know" (March 2016)
Holistic Treatment for CSF Disorders, NeuroLogic (Fall 2015)
Johns Hopkins, Cincinnati Children's launch PHR app for hydrocephalus, MobiHealthNews (10/28/2015)
Comprehensive Treatment for CSF Disorders Johns Hopkins Bayview Health & Wellness (Feb 1, 2016)

redpajama_set_name: RedPajamaCommonCrawl


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February 2018 snapshots: Autonomous vision, machine learning, and artificial intelligence
In the February 2018 snapshots, learn about a company developing machine learning software for autonomous vision, a partnership between Intel and Warner Bros. for in-cabin autonomous vehicle entertainment, a microscope using artificial intelligence algorithms for malaria detection, and a 5K panoramic video camera.
Machine learning enables autonomous vision
Machine learning startup Algolux has their eye toward the next wave of vision. This past November, I visited with Algolux CEO Allan Benchetrit, who told me that many of today's vision systems are sub-optimal for several applications his company sees in themarket.
"Typical architecture may include a lens, camera, and image signal processor (ISP). The ISP gets hand tuned to provide pleasing images for humans to be able to see. The problem is that the ISP takes the raw data off the sensor and strips away much of the data, to create a visually pleasing image."
He continued, "Another problem exists because in a vision architecture, it is the same process being applied. If you are taking these visually-pleasing images and feeding them into a neural network, some of the critical data may be missing from a computer vision standpoint. Algolux aims to address this opportunity by two means, the first of which is its CRISP-ML desktop tool that uses machine learning to automatically optimize a full imaging and visionsystem.
CRISP-ML features an optimal way to tune existing architectures according to Benchetrit. The tool "effectively combines large real-world datasets with standards-based metrics and chart-driven key performance indicators to holistically improve the performance of camera and vision systems." This, according to Algolux, can be done across combinations of components and operating conditions previously deemed as unfeasible.
While CRISP-ML is used for camera preparation, Algolux's CANA product is far more disruptive as it is embedded in the actual camera, according to the company. Benchetrit explained that, as of now, there is a big race for automotive companies to get to level 3 autonomy by 2020. The problem is that the baseline for level 3 is pretty low, he said, for example in places with sunshine, dry roads, no weather distortions, during the day, etc. When these systems encounter difficult conditions, they are not able to process results with the desired level of confidence and consistency, he said.
"What we are doing is focusing on the hard cases, by supporting low light, darkness, distortion caused by weather like rain or fog, and so on; which is the reason that we are breaking away from the legacy architectures of vision systems," said Benchetrit. "We are doing this by replacing the most problematic component (image processor) with a deep learning framework. We are able to discard the image processor and use the data off of the image sensor to train our model to be able to perform in sub-optimalconditions."
He added, "We are doing something that everyone in the automotive industry needs and cannot necessarily work on right now because they are focused on achieving baseline standards of level 3. We are addressing the evolution of vision systems using machinelearning."
Together, CRISP-ML and CANA are enabling the design and implementation of a full software stack for image processing in a component-agnostic manner; this provides better results while reducing cost and enables a faster time-to-market, according to the company. The company has several customers of CRISP-ML while the CANA technology is in pilots, as the company is focusing on customers' short-term needs.
"We are telling our customers to take an existing example of something challenging, show us the baseline, and let us prove to you that we can do better in the exact same conditions. Once we have proven this, let's take on some more use cases, and from there, run it on your platform and go from there. Eventually, we will take on more and more cases, until we have proven that it can work on the clear majority of difficult cases," saidBenchetrit.
For now, the ultimate goal of the company is to deliver on the promise of multi-sensor fusion, assimilating multiple data points from various sensors in real-time.
"We are not encumbered by legacy architecture or components. We believe we will be the first to be able to support multi-sensor fusion in level 3 autonomous driving and beyond," hesaid.
Looking toward possible applications outside of autonomous vehicles, Benchetrit indicated the software packages could be used in security and surveillance, border patrol, or in "any embedded camera that is going to be put through a variety of unpredictable use cases in changing conditions," including mobile devices, drones, and augmented reality/virtual reality.
Intel and Warner Bros. announce partnership on in-cabin autonomous vehicle entertainment
While much of the recent coverage of autonomous vehicles tends to focus on the enabling technology, safety, investments, and product developments; one of the aspects of a real driverless car society that is not discussed is what people may be able to do with their time without having to drive.
Intel-a company with a massive, ambitious vision for autonomous vehicles (AV)-has announced a partnership with Warner Bros. to develop in-cabin, immersive experiences in AV settings. This partnership was announced on November 29 during Automobility LA in Los Angeles, where Intel CEO Brian Krzanich shed further light on the project.
"Called the AV Entertainment Experience, we are creating a first-of-its-kind proof-of-concept car to demonstrate what entertainment in the vehicle could look like in the future," he wrote. "As a member of the Intel 100-car test fleet, the vehicle will showcase the potential for entertainment in an autonomous driving world."
He added, "The rise of the AV industry will create one of the greatest expansions of consumer time available for entertainment we've seen in a long time. As passengers shift from being drivers to riders, their connected-device time, including video-viewing time, will increase. In fact, recent transportation surveys indicate the average American spends more than 300 hours per year behind thewheel."
With all of this time available, Intel and Warner Bros. imagine "significant possibilities inside the AV space," including content such as movies and television programming, but also new, immersive experiences courtesy of in-cabin virtual reality (VR) and augmented reality (AR) innovations.
"For example, a fan of the superhero Batman could enjoy riding in the Batmobile through the streets of Gotham City, while AR capabilities render the car a literal lens to the outside world, enabling passengers to view advertising and other discovery experiences," explainedKrzanich.
These possibilities, he explained, are fun to imagine, but the ultimate test for the future of autonomous cars is going to be winning over passengers. The technology will ultimately not matter if there are no riders who trust and feel comfortable using it. Intel is ultimately working toward this, as its Mobileye ADAS (advanced driver assistance system) technology on the road has proven to reduce accidents by 30%, save 1,400 lives, prevent 450,000 crashes, and save $10 billion in economic losses, according to the company.
The long-term goal of course, has to be zero driving-related fatalities, wrote Krzanich, who said that, "to reach this goal, we need standards and solutions that will enable mass production and adoption of autonomous vehicles. For the long period when autonomous vehicles share the road with human drivers, the industry will need standards that definitively assign fault when collisionsoccur."
To this end, Intel is collaborating with the industry and policymakers on how safety performance is measured and interpreted for autonomous cars. Already, Intel and Mobileye have proposed a formal mathematical model called Responsibility-Sensitive Safety (RSS) to ensure, from a planning and decision-making perspective, the autonomous vehicle system will not issue a command leading to anaccident.
"From entertainment to safety systems, we view the autonomous vehicle as one the most exciting platforms today and just the beginning of a renaissance for the automotive industry," saidKrzanich.
View the Intel autonomous driving press kit - http://bit.ly/VSD-INT.
Intelligent vision platform provides 180° field of view
Altia Systems' PanaCast 2s is a software-defined panoramic 5K video camera system that produces 78% higher resolution than panoramic 4K and provides a 180° field of view and real-time stitching for use in medium-to-large conference rooms for video collaborationapplications.
PanaCast 2s, which was recognized as a CES 2017 Innovation Awards Honoree, implements the PanaCast video processor as a PanaCast Computer Vision Engine (PCVE), which the company calls an industry-first, software-scalable implementation with an OpenCL pipeline. The PCVE uses CPU and GPU processing to achieve high performance, low latency video and reportedly delivers 4x lossless digital zoom up to 16 ft. at 720p and 30 fps. Additionally, the platform enables the integration of artificial intelligence technologies such as machine vision using convolutional neural networks for video collaboration and distance learningapplications.
The camera itself features a 7.4 MPixel CMOS image sensor and a frame rate of up to 30 fps and can be used for "intelligent vision capabilities," including people counting and facial recognition, according to Altia Systems. PanaCast 2s is recommended to be used with an Intel Core i7 processor-based NUC mini-PC. With Intel's initial guidance on the OpenCL pipeline, Altia Systems noted that it developed the PCVE software for PanaCast 2s on such adevice.
"Intel and Altia Systems have collaborated to optimize and deliver an industry leading OpenCL based real-time, scalable, ultra-high definition panoramic camera pipeline for PanaCast 2s on the Intel Core i-series processor family to enable more immersive collaboration and computer vision usages," said Praveen Vishakantaiah, VP and GM of Intel Client Computing Group R&Ddivision.
PanaCast 2s supports Altia Systems' software products, including Intelligent Zoom and PanaCast Vivid. Soon, the device will support PanaCast Whiteboard, people recognition and API for artificial intelligence and machine learning-based applications. The platform is available as a bundled offering through the company's Authorized Intelligent Vision Partners.
Artificial intelligence software helps microscope detect malaria in blood samples
Advanced microscope designer and manufacturer Motic has partnered with the Global Good Fund to create and distribute the EasyScan GO, which is a microscope equipped with artificial intelligence technology that will be used to identify and count malariaparasites.
As part of the collaboration, the software from Global Good-a collaboration between Intellectual Ventures and Bill Gates to develop technologies for humanitarian impact-is integrated into an existing Motic microscope to be used for diseasescanning.
Malaria kills almost half a million people each year, and researchers estimate that nearly half the world's population is at risk of contracting it, according to Motic. Accurate detection of severe and drug-resistant cases requires analysis of a blood smear by a World Health Organization-certified expert microscopist, which takes roughly 20 minutes per slide. By automating the process, this can alleviate the shortfall of trained personnel in under-resourcedcountries.
Based on machine learning and neural networking, EasyScan GO's software module is trained by feeding it thousands of blood smear slides annotated by experts. The microscope works through a combination of digital slide scanning and the software module, which runs captured images through a machine learning algorithm for counting and detection. Field tests of an early prototype of the microscope presented at the International Conference on Computer Vision (ICCV) showed that the machine learning algorithm developed by Global Good is as reliable as an expert microscopist, according toMotic.
"Our goal in integrating Global Good's advanced software into Motic's high-quality, affordable digital slide scanner is to simplify and standardize malaria detection," said Richard Yeung, Vice President of Motic China. "Success with the most difficult-to-identify disease paves the way for the EasyScan product line to excel at almost any microscopy task and to detect other major diseases that affect developed and emerging marketsalike."
Now, the EasyScan GO is being trained to recognize all species of malaria and other parasites and traits commonly found on a blood film, including Chagas disease, microfilaria, and sickle cell. Additionally, the team will reportedly explore application on other sample types, such as sputum, feces and tissue, as well some forms of cancer.
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The Crysta high-speed camera system, designed for two-dimensional analysis of birefringence measurements, will be shown by Photron USA, Inc. at SPIE Photonics West 2019. The camera system combines a photonic-crystal micro polarizer array attached directly to a 1 MPixel CMOS high-speed camera sensor with 20 µm pixels and 1024 x 1024 resolution.
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The IR-2200 infrared microscope system, to be shown by Seiwa Optical America, Inc. at Photonics West 2019, combines an infrared tabletop microscope system and a 4.1 MPixel USB3 NIR camera. According to Seiwa Optical, the IR-2200 is appropriate for inspection of sub-surface images. IK1513 and IK1523 SWIR cameras are the two options for IR-2200 systems.
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GBB: Chargers fall to Warriors
DANVILLE – The Danville girls' basketball team has had North Montgomery's number over the past two years. In the past two seasons the Warriors have downed the Chargers by at least 40 points and Friday night's Sagamore Conference battle was no different. The Warriors continued to get back to their winning ways after a tough opener in last week's Hendricks County tournament routing North Montgomery 66-28. Warrior coach Kaley May, who has seen her fair share of lopsided victories in six seasons at the helm, notes there are some challenges in playing games against competition you're supposed to beat handily. "I think this was a good opportunity to get better at things that you do," May said. "So, try to perfect the way you run plays, look for different options and we kept preaching playing perfectly fundamental defense." In addition to running their normal offense, the Warriors (14-4, 5-0 Sagamore Conference) were able to get some of their players some extra shot confidence. Haley Godwin, Peyton Turner and Arionna Pettijohn were just a few of the players given the greenlight to shoot at will. Another positive note for the Warriors was the return of point guard Chloe Gould, who came off the bench in spurts to spell either Ella Collier or Maddie Patterson. Gould is a key piece for the Warriors if they plan to make another long run in the postseason. She had been sidelined with a foot injury and only played in the first half. "We're definitely on a restriction and we're just trying to work her back in," May said. "It was so good to see her back out there. She's such an energetic kid on and off the floor and she's so positive to have around the team." Danville and Tri-West have been the tops in the conference over the past couple of seasons and, from May's perspective, the needed improvement for the Chargers (3-16, 1-4 SAC) is to take better care of the basketball. She explains some of the difficulties North Montgomery faces are akin to when the Warriors play up against Class 4A competition in the greater-Indianapolis area. "We've played against teams that really pressure you, are bigger than you — 4A teams tend to be that way — and, in those games, it's really hard not to turn the ball over," May said. "I think [North Montgomery] did a nice job of trying to (run) backdoor cuts on us after we pressured, they did a nice job of having a release option in the press and I think just taking care of the ball is the focal point." Collier led the way for the Warriors with 18 points, dogged closely by Patterson, who notched 17. Haley Godwin and Jenna Cowart scored nine and eight, respectively, and Katie Davis scored six. Maddie Moseley paced the Chargers with five points. Kendall Humphreys, Grace McClaskey, Katie Rice and Nina Gable each scored four. Danville welcomes Lafayette Central Catholic tonight at 7:30 p.m. while the Chargers are off until next Tuesday for a tilt with Seeger.
North Montgomery


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Office for Contemporary Art Norway
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Agenda for `A Public Meeting: Norway's Official Representation in La Biennale di Venezia (Visual Arts section) / The Future'
Published 2012/11/19
Norsk versjon
OFFICE FOR CONTEMPORARY ART NORWAY calls
A Public Meeting:
Norway's Official Representation in La Biennale di Venezia (Visual Arts section) / The Future
Tuesday, 20 November / 19:00
Nedre Gate 7
www.oca.no l info@oca.no
OCA holds a public meeting at its premises in Nedre gate 7 on Tuesday, 20 November at 19:00 in an effort to openly explore the official Norwegian representation at the Venice Biennale and its possible future model with the aim to invite public views from those within the professional art community. Within such an autonomous platform, the meeting hopes to address the real needs for such a presentation in the future in an effort to build a constructive discussion as to how to address recurrent issues that relate to this forum in the past. Should Norway secure an earmarked allocation for the Venice Biennale so that this is visible both nationally and internationally? What is the optimal level of such an allocation to meet the minimum ambitions for such a project within the frame of the Venice Biennale today? Should OCA be the central authority in the development of the official Norwegian representation in the Venice Biennale? Should KUD form a council of professionals as an advisory body – even international in scope to advise on these matters? These and other issues are hoped to be addressed under the following agenda*.
Gro Bonesmo, Chair of the Board, OCA
II. OCA and the history of the Venice Biennale since 2003
Marta Kuzma, Director, OCA
III. Short Presentations
Ebba Moi, Member of the Board, NBK
Marianne Hurum, Chair of the Board, UKS
Geir Harald Samuelsen, Chair, Visual Arts, Arts Council Norway
On participating in the Nordic Pavilion in the 1999 Venice Biennale
Knut Åsdam, Artist
IV. Open discussion and response
V. Closing remarks and conclusions
Velaug Bollingmo, Senior Advisor, Arts Council Norway
Sverre Gullesen, Chair of the Board, Kunstnernes Hus
*Please notice that the meeting will be held mainly in Norwegian.
A Public Meeting: Norway and La Biennale di Venezia / The Future
Hanns Karlewski, Façade of the Nordic Pavilion within the XXXIV International Art Exhibition, La Biennale di Venezia, Venice, Italy (1968)
In Spring 2012, Norway's Ministry of Culture (KUD) released the White Paper #23 on Visual Arts, which laid out, in Chapter 7 under point 7.2.3. Conclusion and evaluation of actions:
OCA was founded as an independent professional organ with a mandate to evaluate what would be more beneficial in the international process of exchange in the visual field. With increased globalisation it is important to have an organisation like OCA to attend to and place the Norwegian art world on the international scene. The registration of a rise in applications for international participation for Kulturrådet (Arts Council Norway) may be a signal pointing to the fact that OCA does not have enough funding.
The proposed action point leading out of this conclusion reads:
The Ministry of Culture will assess the need for strengthening OCA's international activities in connection with the budget.
On 8 October, the proposed national budget for 2013 was released, whereby KUD stated that they had attained 'the best cultural budget ever', claiming they 'are about to reach their goal that was set with "The Culture Lift" (Kulturløftet) in 2004 and 2009, where one of the goals was that 1% of the state budget should be allocated to culture by the year 2014'. Although the White Paper #23 on Visual Arts set out a frame for actions to be considered in terms of the formulation of a future cultural policy and strengthening of budget in relation to internationalisation, OCA was overlooked in terms of possible increases for 2013 (other than for an adjustment according to consumer price index).
The central issue of this public call is to note that OCA, as organiser and commissioner for the official Norwegian representation at La Biennale di Venezia, has expressed within the past three annual budget applications a need for KUD to dedicate an earmarked and increased budget toward Norway's official representation within La Biennale di Venezia (Visual Arts section). (These requests incorporated into OCA's annual budget application were in the amounts of 800.000 NOK for the 2009 edition, 3.88 million NOK for the 2011 edition, and 1 million NOK for the 2013 edition – increase requests that were not granted). With the absence of a budget increase across the past three years, OCA has effectively faced a deficit in order to meet the challenges of organising such a project without constructive negotiations on how to meet these challenges in the future. In numerous past meetings, OCA has also expressed the need for a comprehensive evaluation to be conducted in relation to the financial and structural support for the official Norwegian representation at La Biennale di Venezia to reflect the dramatic changes that have affected the costs and realities of mounting an exhibition of contemporary art within the context of the Biennale, especially within the rotation format.
On the same day of the announcement of the national budget, OCA held a meeting of Norwegian art professionals to discuss the pressing issues relating to Norway's official representation in Venice – for 2013 and into the future. The conclusion reached by the group was to host a public meeting at OCA's premises for this topic to be taken publicly to bring the following questions and issues to the forefront:
– The optimal formulation of a budget for the official Norwegian representation at La Biennale di Venezia
– How is this budget reviewed, earmarked, and allocated by KUD?
– What is the optimal budget, both with the Nordic pavilion available and/or without the Nordic pavilion?
– Why both ministries KUD and UD do not cooperate on the funding of the official Norwegian representation at La Biennale di Venezia?
– What has the role of Arts Council Norway been in the past as supplemental in funding the official representation?
– Should OCA be the central authority in the construction of the official Norwegian representation in Venice?
– Should OCA be the commissioner to hire the curator for the official representation?
– Should KUD form a council of professionals as an advisory body – even international in scope to advise KUD on such matter?
– Are there alternative optimal formats?
– Should the Nordic cooperation continue into the future after the conclusion of the agreement for the rotational model adopted for the years 2011–2015?
OCA holds this public meeting at its premises in Nedre gate 7 on Tuesday, 20 November, at 19:00 in an effort to openly explore these points in a discussion and debate with the aim to elicit public views from those within the professional art community and as a way to address Norway's official representation at La Biennale di Venezia for the future as an autonomous platform. In doing so, the meeting hopes to address the real needs of this forum away from the heated political debates around OCA as an institution.
This public meeting was called after a session at OCA to discuss the problems and polemics of this situation with members of the arts community that included among others:
Birgit Bærøe, Head of Section, Visual Arts, Arts Council Norway
Ina Blom, Critic, Curator and Professor in Art History, University of Oslo (UiO)
Velaug Bollingmo, Senior Advisor, Arts Council Norway, part of founding of OCA
Marianne Hurum, Chair of Board, Unge Kunstneres Samfund (UKS)
Jørn Mortensen, Dean, Visual Arts, Oslo National Academy of the Arts (KHiO), former Associate Director, OCA
For more information related to the meeting please contact OCA's Anne Charlotte Hauen, Administrative Associate or Maria Moseng, Press Officer.
Norway at the 55th International Art Exhibition, La Biennale di Venezia 2013 Press Release
dOCUMENTA (13) – last week on view
OCA Semesterplan – Winter/Spring 2012 Released
OCA presents a solo exhibition by artist and author Matias Faldbakken
PORTRAIT PORTRAIT OF OF
A A GENERATION GENERATION
Curated by Marta Kuzma
29 March–23 June 2012
Opening: Wednesday 28 March, 19:00
Press Preview: Tuesday 27 March, 11:00
A sculpture is something that if it falls on your foot, it will break it.
— John Chamberlain
Sculpture is something you bump into when you back up to look at a painting.
— Ad Reinhardt
The Office for Contemporary Art Norway is pleased to announce a solo exhibition by Matias Faldbakken entitled PORTRAIT PORTRAIT OF OF A A GENERATION GENERATION, curated by Marta Kuzma. This exhibition reflects Faldbakken's continued interest in morphing a pre-existing language of forms into a deadpan vernacular. Through suspect negotiations and inferred mediations, Faldbakken sources iconic sculptures produced in the 20th century. The artist essentially de-skills modernist sculpture's aspirations toward the aerodynamic, the minimal, and the abstract by acrobating revered works of 'art' into vessels for intoxication.
In his practice as artist and author, Matias Faldbakken displaces and reconfigures cultural signifiers in order to create a field of agitated idleness. In imposing a rupture to the original sequences of reading and interpretation, the artist points to the eradication of cause and effect in an alienated and onanistic society. In this particular project, made possible by the generous cooperation of The Vigeland Museum and with the Haukeland Family, Faldbakken prompts the sculptures and those viewing them to be slam dunked out of inebriated patterned regimens and to seek a rehabilitation of meaning.
Matias Faldbakken (b.1973, Hobro, Denmark, lives and works in Oslo, Norway) has exhibited widely internationally and within Norway. His recent solo exhibitions include The Power Station, Dallas, TX, USA; Kunsthalle Fridericianum, Kassel, Germany; Neuer Aachener Kunstverein, Aachen, Belgium; Kunsthalle St. Gallen, St. Gallen, Switzerland and The National Museum of Art, Design and Architecture, Oslo. He participated in the Nordic Pavilion at La Biennale di Venezia, Venice, Italy in 2005. As an author, his publications include Search (2011), Unfun (2008), Snort Stories (2006), Cold Product (2006), Macht und Rebel (2002), The Cocka Hola Company (2001). Faldbakken received his education from the Academy of Fine Arts, Bergen, Norway and Städelschule, Frankfurt am Main, Germany.
For more information on the exhibition, please contact OCA press officer Maria Moseng.
The Office for Contemporary Art Norway is a foundation created by The Norwegian Ministry of Culture and The Norwegian Ministry of Foreign Affairs in autumn 2001. The main aim of the Office for Contemporary Art Norway is to develop collaborations in contemporary art between Norway and the international art scene. The Office for Contemporary Art Norway aims to become a key contributor to the discourses of contemporary art.
Faldbakken individual
dOCUMENTA (13) online professional accreditation now open
OCA announces Condition Report: A symposium organised by Raw Material Company in Dakar, Senegal
OCA ANNOUNCES
the participation of Anne Szefer Karlsen, Stian Eide Kluge, Steffen Håndlykken, Linus Elmes, Mohamed Ali Fadlabi and Jet Pascua in
On building art institutions in Africa
A symposium in Dakar, Senegal, organised by Koyo Kouoh and the Raw Material Company
18–20 January 2012
www.rawmaterialcompany.org
OCA is pleased to announce the Norwegian participation in Condition Report, a 3-day international symposium on building art institutions in Africa organised by Raw Material Company in cooperation with the Goethe Institut and German Federal Cultural Foundation. The symposium takes place in Dakar, Senegal, from 18-20 January 2012. Representatives from Norwegian cultural initiatives invited by Koyo Kouoh (director of Raw Material Company and a participant in OCA's International Visitor Programme in 2010) to take part in the symposium include Anne Szefer Karlsen (director of Hordaland Art Centre, Bergen), Stian Eide Kluge and Steffen Håndlykken (directors of 1857, Oslo), Linus Elmes (director of UKS, Oslo), Mohamed Ali Fadlabi (artist and curator of One Night Only exhibition series, Oslo) and Jet Pascua (director of Small Projects, Tromsø).
According to the organisers, 'Condition Report aims to address the changing role of art institutions and initiatives in relation to the broader artistic urgencies, and in relation to the society in its whole. The symposium is organised to evaluate a founding principle of many independent organisations that have emerged in recent years – namely that independent contemporary art institutions are an important voice in the construction of a strong cultural private sector as well as in forging a critical opinion from an open civil society. The importance of issues of action, space, power, control and quality will be covered. The sessions will also provide a platform for discussing case studies and experiences accompanied by an informed interpretative analysis'.
The symposium is divided into three leading chapters broken down into multiple sessions. In an effort to contextualise the African art scene and facilitate access and exchange to international participants, site visits to local art institutions are an integral part of the programme. The first chapter, Actors, Agents and Mainstream, 'looks at existing institutions and how they work to build a shared understanding of artistic agency'. The second chapter, Remains of the Days, 'discusses how former colonial powers define and implement their strategies of cultural representation and exchange in post-colonial areas'. The Norwegian delegation will participate in the third chapter titled Area Studies, which 'investigates models and profiles of art institutions developed in other regions of the world with similar historical and contemporary settings'. The session scheduled on Friday, 20 January, titled Case Study: Norway, will elaborate upon a grass roots impulse that is assuming the scene of contemporary art and how it relates to international exchange.
Other international participants in the symposium include Abdellah Karroum (Appartement 22, Rabat, Morocco); Yto Barrada (Cinémathèque de Tanger, Tanger, Morocco); Oyinda Fakeye (Center of Contemporary Art Lagos, Lagos, Nigeria); Juan Gaitan (Witte de With, Rotterdam, the Netherlands); Livia Paldi (Baltic Art Centre, Visby, Gotland county, Sweden); Kerstin Pinther (Free University, Berlin, Germany); Dirk Snauwaert (Wiels Contemporary Art Centre, Brussels, Belgium); Ousseynou Wade (Dakar Biennale, Dakar, Senegal) and Marie-Cécile Zinsou (Fondation Zinsou, Cotonou, Benin), among others.
About Raw Material Company
Raw Material Company is a not for profit center for art, knowledge and society. It is an art initiative unfolding within the realms of exhibition making, commissioning, knowledge sharing, and archiving of theory and criticism. It works to foster appreciation and growth of artistic and intellectual creativity in Africa.
For press inquiries and more information on this announcement, please contact OCA´s Head of International Relations Paul Brewer, or Odette Laurent and Camille Osterman from Raw Material Company.
About the Norwegian symposium participants
Mohamed Ali Fadlabi (b.1975) is a Sudanese-Norwegian painter based in Oslo. He works mainly with paintings, performance and text, and has had exhibitions in Norway, Germany, Sudan, Sweden, Switzerland and France. In addition to his bachelor's from the National Academy of the Arts, where he is currently working on his master's degree, he received a bachelor's in political science at Elnaileen University 1995-1999, and studied painting at the Sudan University 1995-1997. Fadlabi is the founder of One Night Only Gallery in Oslo. He grew up in Sudan's capital Khartoum. After his political alliances and activities forced him to leave Sudan, he arrived in Norway in 2003 where he was granted political asylum.
Anne Szefer Karlsen (b.1976) is a curator based in Bergen, Norway currently director of Hordaland Art Centre (2008-2014), which was established in 1976 as the first artist run art centre in Norway. Hordaland Art Centre is a non-profit gallery space, a residency programme and a bookshop and café. Szefer Karlsen is trained as an artist and curator, and for a number of years she acted as an independent curator as well as producer of different events and festivals. She was co-founder of Flaggfabrikken ー Centre for Photography and Contemporary Art (2002-2008) and is the co-founding editor of Ctrl+Z Publishing (since 2006).
Steffen Håndlykken (b.1981) is an artist living and working in Oslo. Recent exhibitions include Kunstnerforbundet, Oslo and The Drawing Biennial, Moss, and, as part of the artist group Institute for Colour: 0047, Oslo; Volt, Bergen; and Common Lands, Oslo. In 2010 he founded 1857 with Stian Eide Kluge, an artist-run space devoted to producing new projects by international artists. Since 2009 he has been co-editor for UKS-forum, a journal of contemporary art and theory published by the Young Artists Society in Oslo.
Stian Eide Kluge (b.1977) lives and works in Oslo. He is a graduate from the National Academy of Art and Design, Oslo and School of Visual Arts, Department for Film in New York. His work has recently been shown at Kunstnerforbundet, Galleri Erik Steen, 0047, Galleri Trafo and Galerei Gabriel Rolt. In 2010 he founded 1857 with Steffen Håndlykken, an artist-run space in Oslo devoted to producing new projects by international artists.
Jet Pascua (b.1969) is a Filipino-born visual artist now residing in Tromsø, Norway. He studied at the University of the Philippines, Department of Fine Arts, the National Academy of Fine Arts, Oslo and the National Academy of Fine Arts, Bergen in where he attained his Master in Fine Arts degree. He has also taken part and organized several group and solo exhibitions internationally. He is the founder and director of Small Projects, a non-profit artist-run gallery supported by the Norwegian Arts Council and the city of Tromsø.
Linus Elmes (b.1972) is an artist, curator and writer with a background in Swedish artist initiated projects such as the deliberative collaborative project ak28 and the imaginary experiment Ersta Konsthall. He is currently director at UKS (Young Artists Society) in Oslo.
About O3–funds
Condition Report has been supported by O3–funds as underwritten by the Norwegian Ministry of Foreign Affairs for enhancing collaboration in the contemporary art field with professional artists in countries designated by the MFA. The purpose of the O3–funds as allocated to OCA is to further develop cooperation and professional networking between OCA and the constituency of artists, independent cultural producers, and organisations that are located in designated countries. This includes but is not limited to 'professional research visits by cultural producers, artists, and curators', 'short-term residencies for cultural producers and artists', 'seminars, conferences, art projects, workshops that focus on the further development of professional exchange and networking between and among countries', and 'project development on an international scale'.
Publication of the OCA Annual Report 2010
The OCA Annual Report 2010 is out and has been added to the Annual Reports page.
Meet Carolina Caycedo
OCA Spring Recap 2019
Michael Taussig on "Recipes for Survival" + Public conversation
Meet Devika Singh
Venice Special Newsletter
A Gift to Svalbard
Meet Wanda Nanibush
Meet Brook Andrew
Meet Oswaldo Macía
SápmiToo
Meet Zachary Kaplan
OCA Director Katya Garcia-Antón honouring Synnøve Persen
Press release: OCA announces Sovereign Words. Indigenous Art, Curation and Criticism
Book launch: Sovereign Words. Indigenous Art, Curation and Criticism
Meet Stephanie Seidel
Film screening with María Inés Rodriguéz
Grants::International Residencies
Grants::International Support
Publications::Verksted Series
SemesterPlan::Norway in Venice
SemesterPlan::Projects
SemesterPlan::SemesterPlan
SemesterPlan::Seminars / Lectures
Studio Programme
Visitor Programme


Additional Info: Also available is a 120bhp 1.8 0-60 in low 10's, a 1987-1992 148bhp 2.0 Twin Spark 0-60 in 8.2-9.3 secs and a 1986-1991 156bhp 2.5 V6 0-60 9 secs (manual) 10 secs (auto). The 3.0 V6 ran from 1987-1992 and the power rose to 192bhp in 1990. Also to note is a 152-165bhp 1.8 Turbo 0-60 in around 7.5 secs (unsure if this was available in the UK?), also a limited number of 500 Turbo Evo's were built.


Jana Kramer hardly strikes me as a Frosted Flakes kind of girl. But then again, now that I know all the completely random things she keeps in her purse, I feel like she's full of surprises.
She carries a sterling silver boomerang key chain from her One Tree Hill fans in Australia, Lancôme Absolue moisturizer, original ChapStick, Nars Michiyo lipstick, an Emily Giffin book (right now it is Love the One You're With), foam ear plugs, bug spray, a black Tory Burch wallet, credit cards, a Sephora VIB Rouge rewards card, a high school picture of her husband (NFL player Mike Caussin), a gold iPhone 6, Tylenol, Advil, Degree deodorant, Colgate Optic White, gum, hand sanitizer, a sewing kit, hair ties, Burberry sunglasses, a bottle of SmartWater, Pirate's Booty, and most importantly for the "I Got the Boy" singer, a black leather notebook for song lyrics.
The bag itself is just a temporary one from Target, "until I find the perfect bag for me," Kramer said.
Here's a never before heard taste of #thirtyone! A song called 'Don't Touch My Radio' Link to preorder my album and hear more new music before Friday is in my bio!


text:
using namespace std;

template<class Interface>
class Action_atv_product {

public :

  Action_atv_product( int size ) : _size(size)
  {
    MESSAGE("Action_atv_product Ctor");

    // STL matrix and vector initialization

    init_matrix<pseudo_random>(A_stl,_size);
    init_vector<pseudo_random>(B_stl,_size);
    init_vector<null_function>(X_stl,_size);
    init_vector<null_function>(resu_stl,_size);

    // generic matrix and vector initialization

    Interface::matrix_from_stl(A_ref,A_stl);
    Interface::vector_from_stl(B_ref,B_stl);
    Interface::vector_from_stl(X_ref,X_stl);

    Interface::matrix_from_stl(A,A_stl);
    Interface::vector_from_stl(B,B_stl);
    Interface::vector_from_stl(X,X_stl);
  }

  // invalidate copy ctor
  Action_atv_product( const  Action_atv_product & )
  {
    INFOS("illegal call to Action_atv_product Copy Ctor");
    exit(1);
  }

  ~Action_atv_product( void )
  {
    MESSAGE("Action_atv_product Dtor");

    Interface::free_matrix(A,_size);
    Interface::free_vector(B);
    Interface::free_vector(X);

    Interface::free_matrix(A_ref,_size);
    Interface::free_vector(B_ref);
    Interface::free_vector(X_ref);
  }

  static inline std::string name() { return "atv_" + Interface::name(); }

  double nb_op_base( void ) { return 2.0*_size*_size; }

  inline void initialize( void ){
    Interface::copy_matrix(A_ref,A,_size);
    Interface::copy_vector(B_ref,B,_size);
    Interface::copy_vector(X_ref,X,_size);
  }

  BTL_DONT_INLINE void calculate( void ) {
    BTL_ASM_COMMENT("begin atv");
    Interface::atv_product(A,B,X,_size);
    BTL_ASM_COMMENT("end atv");
  }

  void check_result( void )
  {
    Interface::vector_to_stl(X,resu_stl);

    STL_interface<typename Interface::real_type>::atv_product(A_stl,B_stl,X_stl,_size);

    typename Interface::real_type error=
      STL_interface<typename Interface::real_type>::norm_diff(X_stl,resu_stl);

    if (error>1.e-6){
      INFOS("WRONG CALCULATION...residual=" << error);
      exit(1);
    }
  }

private :

  typename Interface::stl_matrix A_stl;
  typename Interface::stl_vector B_stl;
  typename Interface::stl_vector X_stl;
  typename Interface::stl_vector resu_stl;

  typename Interface::gene_matrix A_ref;
  typename Interface::gene_vector B_ref;
  typename Interface::gene_vector X_ref;

  typename Interface::gene_matrix A;
  typename Interface::gene_vector B;
  typename Interface::gene_vector X;

  int _size;

};

#endif

redpajama_set_name: RedPajamaGithub


text:
Bradford repel Oldham fightback at Odsal
TWO late tries by winger Dalton Grant flattered Bradford Bulls in a 30-12 win at Odsal which was more competitive than the score suggests.
Oldham's best spells were in the build-up to half-time, when they trailed 12-0, and early in the second half when Kyran Johnson and Craig Briscoe scored tries to put the Roughyeds choir in full voice.
It was then, with Bulls only 18-12 ahead, that Paul Crook had a try under the sticks chalked off for offside after the Oldham skipper had chased down Dave Hewitt's excellent cross-kick with the outside of his 'wrong' (right) foot.
Had that effort been allowed to stand the whole balance of the game would have changed with the scores locked up at 18-18 .
In the event, Bulls immediately stretched their lead to 20-12 with a penalty goal, their fourth, and then finished things off with those late touchdowns by Grant.
Four changes in Oldham's 19-man squad
Bradford repel Roughyeds' fightback
Match Reports, News
Season ends in biggest defeat of the year
A SEASON of missed opportunities and mutterings of 'if only' petered out to a disappointing end in a one-sided 47-0 defeat at Bradford Bulls in a Betfred League 1 play-off semi-final.
'I'm glad its all over" — Scott
DESCRIBING Oldham's 2018 season as one of the strangest he had ever been involved in, Scott Naylor said: "To be perfectly honest, I'm glad it's all over."
Season ends with disappointing defeat
| OLDHAM'S 2018 season ended with a disappointing 47-0 defeat by Bradford Bulls at Odsal in the Betfred League 1 promotion semi-final.
Opportunity knocks for banned trio's replacements
Ben Davies, Luke Nelmes and Luke Hooley will each serve one-match RFL bans when Oldham go head to head with Bradford Bulls at Odsal on Sunday


text:
Search Results: 1 - 10 of 100 matches for " "
FOP Is a Centriolar Satellite Protein Involved in Ciliogenesis [PDF]
Joanna Y. Lee, Tim Stearns
Abstract: Centriolar satellites are proteinaceous granules that are often clustered around the centrosome. Although centriolar satellites have been implicated in protein trafficking in relation to the centrosome and cilium, the details of their function and composition remain unknown. FOP (FGFR1 Oncogene Partner) is a known centrosome protein with homology to the centriolar satellite proteins FOR20 and OFD1. We find that FOP partially co-localizes with the satellite component PCM1 in a cell cycle-dependent manner, similarly to the satellite and cilium component BBS4. As for BBS4, FOP localization to satellites is cell cycle dependent, with few satellites labeled in G1, when FOP protein levels are lowest, and most labeled in G2. FOP-FGFR1, an oncogenic fusion that causes a form of leukemia called myeloproliferative neoplasm, also localizes to centriolar satellites where it increases tyrosine phosphorylation. Depletion of FOP strongly inhibits primary cilium formation in human RPE-1 cells. These results suggest that FOP is a centriolar satellite cargo protein and, as for several other satellite-associated proteins, is involved in ciliogenesis. Localization of the FOP-FGFR1 fusion kinase to centriolar satellites may be relevant to myeloproliferative neoplasm disease progression.
Expression and Purification of Chaperone-Active Recombinant Clusterin [PDF]
Rebecca A. Dabbs, Mark R. Wilson
Abstract: Clusterin was the first described secreted mammalian chaperone and is implicated as being a key player in both intra- and extracellular proteostasis. Its unique combination of structural features and biological chaperone activity has, however, previously made it very challenging to express and purify the protein in a correctly processed and chaperone-active form. While there are multiple reports in the literature describing the use of recombinant clusterin, all of these reports suffer from one or more of the following shortcomings: details of the methods used to produce the protein are poorly described, the product is incompletely (if at all) characterised, and purity (if shown) is in many cases inadequate. The current report provides the first well validated method to economically produce pure chaperone-active recombinant clusterin. The method was developed after trialling expression in cultured bacterial, yeast, insect and mammalian cells, and involves the expression of recombinant clusterin from stably transfected HEK293 cells in protein-free medium. The product is expressed at between 7.5 and 10 μg/ml of culture, and is readily purified by a combination of immunoaffinity, cation exchange and size exclusion chromatography. The purified product was shown to be glycosylated, correctly proteolytically cleaved into α- and β-subunits, and have chaperone activity similar to that of human plasma clusterin. This new method creates the opportunity to use mutagenesis and metabolic labelling approaches in future studies to delineate functionally important sites within clusterin, and also provides a theoretically unlimited supply of recombinant clusterin which may in the future find applications in the development of therapeutics.
The architecture of mammalian ribosomal protein promoters
Robert P Perry
BMC Evolutionary Biology , 2005, DOI: 10.1186/1471-2148-5-15
Abstract: A striking evolutionarily conserved feature of most rp genes is the separation by an intron of the sequences involved in transcriptional and translational regulation from the sequences with protein encoding function. Another conserved feature is the polypyrimidine initiator, which conforms to the consensus (Y)2C+1TY(T)2(Y)3. At least 60 % of the rp promoters contain a largely conserved TATA box or A/T-rich motif, which should theoretically have TBP-binding capability. A remarkably high proportion of the promoters contain conserved binding sites for transcription factors that were previously implicated in rp gene expression, namely upstream GABP and Sp1 sites and downstream YY1 sites. Over 80 % of human and mouse rp genes contain a transposable element residue within 900 bp of 5' flanking sequence; very little sequence identity between human and mouse orthologues was evident more than 200 bp upstream of the transcriptional start point.This analysis has provided some valuable insights into the general architecture of mammalian rp promoters and has identified parameters that might coordinately regulate the transcriptional activity of certain subsets of rp genes.Ribosomes are vital organelles, which catalyze protein synthesis in all living organisms. Eukaryotic ribosomes consist of four RNA molecules (rRNAs) and 79 different proteins. The mammalian genes encoding the rRNAs are multicopy and clustered at a few loci, whereas those encoding the ribosomal proteins (rp genes) are single copy and scattered throughout the genome [1]. In addition to the functional rp genes, all of which contain introns, mammalian genomes contain many nonfunctional intronless rp pseudogenes [2]. The earliest determinations of mouse rp gene sequences and of transcriptional start points (tsp's) revealed a salient feature of rp genes, namely that transcription is initiated at a C residue within a polypyrimidine tract [3-5]. A recent study by Kenmochi and coworkers [6] has demonstrated that this is
Localization of a Guanylyl Cyclase to Chemosensory Cilia Requires the Novel Ciliary MYND Domain Protein DAF-25 [PDF]
Victor L. Jensen,Nathan J. Bialas,Sharon L. Bishop-Hurley,Laurie L. Molday,Katarzyna Kida,Phuong Anh T. Nguyen,Oliver E. Blacque,Robert S. Molday,Michel R. Leroux,Donald L. Riddle
Abstract: In harsh conditions, Caenorhabditis elegans arrests development to enter a non-aging, resistant diapause state called the dauer larva. Olfactory sensation modulates the TGF-β and insulin signaling pathways to control this developmental decision. Four mutant alleles of daf-25 (abnormal DAuer Formation) were isolated from screens for mutants exhibiting constitutive dauer formation and found to be defective in olfaction. The daf-25 dauer phenotype is suppressed by daf-10/IFT122 mutations (which disrupt ciliogenesis), but not by daf-6/PTCHD3 mutations (which prevent environmental exposure of sensory cilia), implying that DAF-25 functions in the cilia themselves. daf-25 encodes the C. elegans ortholog of mammalian Ankmy2, a MYND domain protein of unknown function. Disruption of DAF-25, which localizes to sensory cilia, produces no apparent cilia structure anomalies, as determined by light and electron microscopy. Hinting at its potential function, the dauer phenotype, epistatic order, and expression profile of daf-25 are similar to daf-11, which encodes a cilium-localized guanylyl cyclase. Indeed, we demonstrate that DAF-25 is required for proper DAF-11 ciliary localization. Furthermore, the functional interaction is evolutionarily conserved, as mouse Ankmy2 interacts with guanylyl cyclase GC1 from ciliary photoreceptors. The interaction may be specific because daf-25 mutants have normally-localized OSM-9/TRPV4, TAX-4/CNGA1, CHE-2/IFT80, CHE-11/IFT140, CHE-13/IFT57, BBS-8, OSM-5/IFT88, and XBX-1/D2LIC in the cilia. Intraflagellar transport (IFT) (required to build cilia) is not defective in daf-25 mutants, although the ciliary localization of DAF-25 itself is influenced in che-11 mutants, which are defective in retrograde IFT. In summary, we have discovered a novel ciliary protein that plays an important role in cGMP signaling by localizing a guanylyl cyclase to the sensory organelle.
Evolutionarily Conserved Pattern of AMPA Receptor Subunit Glycosylation in Mammalian Frontal Cortex [PDF]
Janusz Tucholski, Anita L. Pinner, Micah S. Simmons, James H. Meador-Woodruff
Abstract: Protein glycosylation may contribute to the evolution of mammalian brain complexity by adapting excitatory neurotransmission in response to environmental and social cues. Balanced excitatory synaptic transmission is primarily mediated by glutamatergic neurotransmission. Previous studies have found that subunits of the AMPA subtype of glutamate receptor are N-glycosylated, which may play a critical role in AMPA receptor trafficking and function at the cell membrane. Studies have predominantly used rodent models to address altered glycosylation in human pathological conditions. Given the rate of mammalian brain evolution and the predicted rate of change in the brain-specific glycoproteome, we asked if there are species-specific changes in glycoprotein expression, focusing on the AMPA receptor. N-glycosylation of AMPA receptor subunits was investigated in rat (Rattus norvegicus), tree shrew (Tupaia glis belangeri), macaque (Macaca nemestrina), and human frontal cortex tissue using a combination of enzymatic deglycosylation and Western blot analysis, as well as lectin binding assays. We found that two AMPA receptor subunits, GluA2 and GluA4, are sensitive to deglycosylation with Endo H and PNGase F. When we enriched for glycosylated proteins using lectin binding assays, we found that all four AMPA receptor subunits are glycosylated, and were predominantly recognized by lectins that bind to glucose or mannose, N-acetylglucosamine (GlcNAc), or 1-6αfucose. We found differences in glycosylation between different subunits, as well as modest differences in glycosylation of homologous subunits between different species.
Development of reverse phase protein microarrays for the validation of clusterin, a mid-abundant blood biomarker
Adriana Aguilar-Mahecha, Christiane Cantin, Maureen O'Connor-McCourt, Andre Nantel, Mark Basik
Proteome Science , 2009, DOI: 10.1186/1477-5956-7-15
Abstract: In the present study we present the development of reverse-phase protein microarrays (RPPMs) for the measurement of clusterin, a mid-abundant blood biomarker. An experimental protocol was optimized for the printing of serum and plasma on RPPMs using epoxy coated microscope slides and a non-denaturing printing buffer. Using fluorescent-tagged secondary antibodies, we achieved the reproducible detection of clusterin in spotted serum and plasma and reached a limit of detection of 780 ng/mL. Validation studies using both spiked clusterin and clinical samples showed excellent correlations with ELISA measurements of clusterin.Serum and plasma spotted in the reverse phase array format allow for reliable and reproducible high-throughput validation of a mid-abundant blood biomarker such as clusterin.The increasing application of genomics and proteomics technologies in medical research is making possible the development of "personalized medicine", i.e. medical care characterized by the use of biomarkers for the molecular diagnosis of different disease states and for the selection of therapies tailored to the individual's disease. Although both tissue and blood biomarkers are being discovered, blood derived-biomarkers are particularly attractive in the clinic since blood collection is inexpensive and relatively non-invasive and blood comes in contact with all tissues in the body. Unfortunately, the translation of putative blood biomarkers into clinical application has been hindered by the lack of a high-throughput technical platform for their validation. ELISAs are the standard method currently used for blood biomarker validation. However, the requirement for large sample volumes (~100 μl) and its low throughput make ELISA a costly method, both in time and biological material, not suited for the rapid validation of clinical samples.A novel technology designed to measure protein levels in a high-throughput fashion is the protein microarray [1,2]. There are two main types of pro
A Role for Alstr?m Syndrome Protein, Alms1, in Kidney Ciliogenesis and Cellular Quiescence [PDF]
Guochun Li,Raquel Vega,Keats Nelms,Nicholas Gekakis,Christopher Goodnow,Peter McNamara,Hua Wu,Nancy A Hong,Richard Glynne
Abstract: Premature truncation alleles in the ALMS1 gene are a frequent cause of human Alstr?m syndrome. Alstr?m syndrome is a rare disorder characterized by early obesity and sensory impairment, symptoms shared with other genetic diseases affecting proteins of the primary cilium. ALMS1 localizes to centrosomes and ciliary basal bodies, but truncation mutations in Alms1/ALMS1 do not preclude formation of cilia. Here, we show that in vitro knockdown of Alms1 in mice causes stunted cilia on kidney epithelial cells and prevents these cells from increasing calcium influx in response to mechanical stimuli. The stunted-cilium phenotype can be rescued with a 5′ fragment of the Alms1 cDNA, which resembles disease-associated alleles. In a mouse model of Alstr?m syndrome, Alms1 protein can be stably expressed from the mutant allele and is required for cilia formation in primary cells. Aged mice developed specific loss of cilia from the kidney proximal tubules, which is associated with foci of apoptosis or proliferation. As renal failure is a common cause of mortality in Alstr?m syndrome patients, we conclude that this disease should be considered as a further example of the class of renal ciliopathies: wild-type or mutant alleles of the Alstr?m syndrome gene can support normal kidney ciliogenesis in vitro and in vivo, but mutant alleles are associated with age-dependent loss of kidney primary cilia.
Wdpcp, a PCP Protein Required for Ciliogenesis, Regulates Directional Cell Migration and Cell Polarity by Direct Modulation of the Actin Cytoskeleton [PDF]
Cheng Cui,Bishwanath Chatterjee,Thomas P. Lozito,Zhen Zhang,Richard J. Francis,Hisato Yagi,Lisa M. Swanhart,Subramaniam Sanker,Deanne Francis,Qing Yu,Jovenal T. San Agustin,Chandrakala Puligilla,Tania Chatterjee,Terry Tansey,Xiaoqin Liu,Matthew W. Kelley,Elias T. Spiliotis,Adam V. Kwiatkowski,Rocky Tuan,Gregory J. Pazour,Neil A. Hukriede,Cecilia W. Lo
PLOS Biology , 2013, DOI: 10.1371/journal.pbio.1001720
Abstract: Planar cell polarity (PCP) regulates cell alignment required for collective cell movement during embryonic development. This requires PCP/PCP effector proteins, some of which also play essential roles in ciliogenesis, highlighting the long-standing question of the role of the cilium in PCP. Wdpcp, a PCP effector, was recently shown to regulate both ciliogenesis and collective cell movement, but the underlying mechanism is unknown. Here we show Wdpcp can regulate PCP by direct modulation of the actin cytoskeleton. These studies were made possible by recovery of a Wdpcp mutant mouse model. Wdpcp-deficient mice exhibit phenotypes reminiscent of Bardet–Biedl/Meckel–Gruber ciliopathy syndromes, including cardiac outflow tract and cochlea defects associated with PCP perturbation. We observed Wdpcp is localized to the transition zone, and in Wdpcp-deficient cells, Sept2, Nphp1, and Mks1 were lost from the transition zone, indicating Wdpcp is required for recruitment of proteins essential for ciliogenesis. Wdpcp is also found in the cytoplasm, where it is localized in the actin cytoskeleton and in focal adhesions. Wdpcp interacts with Sept2 and is colocalized with Sept2 in actin filaments, but in Wdpcp-deficient cells, Sept2 was lost from the actin cytoskeleton, suggesting Wdpcp is required for Sept2 recruitment to actin filaments. Significantly, organization of the actin filaments and focal contacts were markedly changed in Wdpcp-deficient cells. This was associated with decreased membrane ruffling, failure to establish cell polarity, and loss of directional cell migration. These results suggest the PCP defects in Wdpcp mutants are not caused by loss of cilia, but by direct disruption of the actin cytoskeleton. Consistent with this, Wdpcp mutant cochlea has normal kinocilia and yet exhibits PCP defects. Together, these findings provide the first evidence, to our knowledge, that a PCP component required for ciliogenesis can directly modulate the actin cytoskeleton to regulate cell polarity and directional cell migration.
Evolutionarily Conserved Herpesviral Protein Interaction Networks [PDF]
Even Fossum,Caroline C. Friedel,Seesandra V. Rajagopala,Bj?rn Titz,Armin Baiker,Tina Schmidt,Theo Kraus,Thorsten Stellberger,Christiane Rutenberg,Silpa Suthram,Sourav Bandyopadhyay,Dietlind Rose,Albrecht von Brunn,Mareike Uhlmann,Christine Zeretzke,Yu-An Dong,Hélène Boulet,Manfred Koegl,Susanne M. Bailer,Ulrich Koszinowski,Trey Ideker,Peter Uetz,Ralf Zimmer,Jürgen Haas
PLOS Pathogens , 2009, DOI: 10.1371/journal.ppat.1000570
Abstract: Herpesviruses constitute a family of large DNA viruses widely spread in vertebrates and causing a variety of different diseases. They possess dsDNA genomes ranging from 120 to 240 kbp encoding between 70 to 170 open reading frames. We previously reported the protein interaction networks of two herpesviruses, varicella-zoster virus (VZV) and Kaposi's sarcoma-associated herpesvirus (KSHV). In this study, we systematically tested three additional herpesvirus species, herpes simplex virus 1 (HSV-1), murine cytomegalovirus and Epstein-Barr virus, for protein interactions in order to be able to perform a comparative analysis of all three herpesvirus subfamilies. We identified 735 interactions by genome-wide yeast-two-hybrid screens (Y2H), and, together with the interactomes of VZV and KSHV, included a total of 1,007 intraviral protein interactions in the analysis. Whereas a large number of interactions have not been reported previously, we were able to identify a core set of highly conserved protein interactions, like the interaction between HSV-1 UL33 with the nuclear egress proteins UL31/UL34. Interactions were conserved between orthologous proteins despite generally low sequence similarity, suggesting that function may be more conserved than sequence. By combining interactomes of different species we were able to systematically address the low coverage of the Y2H system and to extract biologically relevant interactions which were not evident from single species.
Are residues in a protein folding nucleus evolutionarily conserved? [PDF]
Yan Yuan Tseng,Jie Liang
Quantitative Biology , 2003,
Abstract: It is important to understand how protein folding and evolution influences each other. Several studies based on entropy calculation correlating experimental measurement of residue participation in folding nucleus and sequence conservation have reached different conclusions. Here we report analysis of conservation of folding nucleus using an evolutionary model alternative to entropy based approaches. We employ a continuous time Markov model of codon substitution to distinguish mutation fixed by evolution and mutation fixed by chance. This model takes into account bias in codon frequency, bias favoring transition over transversion, as well as explicit phylogenetic information. We measure selection pressure using the ratio $\omega$ of synonymous vs. non-synonymous substitution at individual residue site. The $\omega$-values are estimated using the {\sc Paml} method, a maximum-likelihood estimator. Our results show that there is little correlation between the extent of kinetic participation in protein folding nucleus as measured by experimental $\phi$-value and selection pressure as measured by $\omega$-value. In addition, two randomization tests failed to show that folding nucleus residues are significantly more conserved than the whole protein. These results suggest that at the level of codon substitution, there is no indication that folding nucleus residues are significantly more conserved than other residues. We further reconstruct candidate ancestral residues of the folding nucleus and suggest possible test tube mutation studies of ancient folding nucleus.