text:
Q: Chromecast send message returns invalid parameter error on my sender side after i successfully create a session I have:
var onRequestSessionSuccess = function(session) {
            var namespace = 'urn:x-cast:super.awesome.example';

            var message = 'It worked!';
            console.log('Session created.');
            session.sendMessage(namespace, message, onSuccess, onFailure);
}

on the receiver side I have:
var namespace = 'urn:x-cast:super.awesome.example';

        var messageBus = castReceiverManager.getCastMessageBus(
            namespace,
            cast.receiver.CastMessageBus.MessageType.JSON
        );

        messageBus.onMessage = function(event) {
            var sender = event.senderId;
            var message = event.data;
            console.log('received message!');
        };

on the onFailure function on the sender app, I console.log the error message and
whenever i run it i get :
Object {code: "invalid_parameter", description: "Invalid namespace", details: null}

how is 'urn:x-cast:super.awesome.example' an invalid namespace? It follows the convention of including 'urn:x-cast:' before the custom part. Also even when I replace the namespaces with something valid like: "google.cast" I get the following error message:
Object {code: "invalid_parameter", description: null, details: null}

what is the invalid parameter here?

A: Be sure the following:
1) namespace is exactly the same on sender and receiver
2) messageBus is created before you run castReceiverManager.start


All Photo's courtesy of Billy F.
"Hey, it looks a little like my garage mate - Capri and Ashley rubbing shoulders (er wings) "
I quickly asked for more details as it was obviously unknown to me, Billy posted back that he had owned it for around 20 years and had not done anything with it, (apart from swapping the Ballamy 15" wheels with a mate's Popular wheels).
The previous owner had brought it in 1971 from the original builder and he had not done anything with it either since that purchase.
Buff car registration log book for the Ford Prefect that the Ashley used for all it's Chassis, Motor/gearbox and running gear.
Which if the car had been finished in the 1960's would have probably been it's registration number.
to another guy in Busby, about 3 miles away, this was were Billy purchased it in around 1998.
(Donor car registered by London C.C.


text:
Effects of austerity continue to bite as 10% of Irish households suffer 'food poverty'
Bryan Wall
A new report has revealed that many Irish people struggle to afford healthy food. The report also noted that "one in ten households" in Ireland experience food poverty. Safefood, which deals with food safety and nutrition in Ireland, highlighted the statistics. Ireland has seen an increase in people having to use food charities due to the effects of austerity over the last 11 years.
Defining food poverty
According to Safefood, food poverty is the "inability to have an adequate and nutritious diet". This issue itself "is multidimensional". Firstly, for example, it involves a "lack of access to a nutritionally adequate diet". Cost is also a problem. Safefood said that there are "are competing pressures within a limited household budget" when it comes to buying food. It went on to state that:
The cost of healthy food is a major contributing factor in people's inability to access a healthy diet.
In some cases, low-income households "need to spend between 14% and 33% of their take-home income to buy a healthy minimum essential food basket".
Added to this is that local shops may not have an adequate stock of healthy food. This is a particular issue in small towns and rural areas where people don't have access to bigger shops with a wider selection.
The DWP agreed a man needed money until his benefits were sorted and then offered him 8p
Emily Apple , 15th January 2020
The DWP's latest policy is a stitch-up
Steve Topple , 14th January 2020
As Johnson prepares to spaff £120m on a Brexit festival, he's soon reminded of where the money should go
Peadar O'Cearnaigh , 13th January 2020
And all of this affects the "health and social participation" of those unable to afford healthy food.
A 'minimum standard of living'
Safefood also defined what it calls a "minimum essential standard of living (MESL)". This, it says, "is a level at which no one should be expected to live below".
But it also pointed out that MESL "is not a poverty standard". Instead, it's used to discover if people can afford a certain "standard of living"; and this, for Safefood, is one that allows "participation in the social and economic norms of Irish society".
But the inability to afford food is nothing new in Ireland. One food charity has seen a large increase in the need for its services over the last few years. Penny Dinners, which offers free meals to people in Cork City, is opening overnight for the first time since the 1800s. According to its website, it now provides 2,000 meals every week compared to "150 or less" before the 2008 recession.
The Irish Times has also reported that, in 2017, 80,000 people received food parcels. And in 2018, the Society of St Vincent De Paul (SVP) divulged that "one in three calls it receives are related to food poverty".
Given Ireland's current housing and homelessness crisis, it's no surprise that so many people are suffering from food poverty. Countless people have to choose between affording a place to live or buying good food. And it seems that, in many cases, the former is taking priority.
Featured image via Pixabay – FotoshopTofs
dave43law says:
We are a relatively new group -9 weeks old with 4500 members and are here to share news, share stories, get information and advice and combat issues with the Universal Credit system In exciting developments this week we have our first FUCA Food Heroes project under development – still looking for food collection volunteers if anyone is interested and a Feed the FUCA's page has been set up too, A resources area is under development .and we network nationwide to resolve immediate issues for the vulnerable as seen this weekend when together with Newcastle Street Friends we managed to sort food, clothing and other items for a young mum with 3 children who had lost everything in a fire at her home. Come join us and vent if you wish whether on benefits or not we are open to all but politeness is requested at all times. …Issues with Universal Credit, news, views, information, support or just a rant.or offer help for a few hours volunteers areneeded too https://www.facebook.com/groups/557907344617657/?ref=group_header
One expert lays out the stark reality of what's needed to avoid climate catastrophe
Onlookers deliver a reckoning after Labour MP fawns over Theresa May's 'touching LGBTQI+ agenda'

redpajama_set_name: RedPajamaCommonCrawl


text:
#ifndef itkNeighborhood_h
#define itkNeighborhood_h

#include <iostream>
#include "itkNeighborhoodAllocator.h"
#include "itkIndent.h"
#include "itkSliceIterator.h"
#include "vnl/vnl_vector.h"
#include "itkOffset.h"
#include <vector>

namespace itk
{
/** \class Neighborhood
 * \brief A light-weight container object for storing an N-dimensional
 * neighborhood of values.
 *
 * This class serves as the base class for several other Itk objects such as
 * itk::NeighborhoodOperator and itk::NeighborhoodIterator.  Its purpose is to
 * store values and their relative spatial locations.
 *
 * A Neighborhood has an N-dimensional \em radius.  The radius is defined
 * separately for each dimension as the number of pixels that the neighborhood
 * extends outward from the center pixel.  For example, a 2D Neighborhood
 * object with a radius of 2x3 has sides of length 5x7.  Neighborhood objects
 * always have an unambiguous center because their side lengths are always odd.
 *
 * \sa Neighborhood
 * \sa NeighborhoodIterator
 *
 * \ingroup Operators
 * \ingroup ImageIterators
 * \ingroup ITKCommon
 */

template <typename TPixel, unsigned int VDimension = 2, typename TAllocator = NeighborhoodAllocator<TPixel>>
class ITK_TEMPLATE_EXPORT Neighborhood
{
public:
  /** Standard class type aliases. */
  using Self = Neighborhood;

  /** External support for allocator type. */
  using AllocatorType = TAllocator;

  /** External support for dimensionality. */
  static constexpr unsigned int NeighborhoodDimension = VDimension;

  /** Run-time type information (and related methods). */
  itkTypeMacroNoParent(Neighborhood);

  /** External support for pixel type. */
  using PixelType = TPixel;

  /** Iterator type alias support Note the naming is intentional, i.e.,
   * AllocatorType::iterator and AllocatorType::const_iterator, because the
   * allocator may be a vnl object or other type, which uses this form. */
  using Iterator = typename AllocatorType::iterator;
  using ConstIterator = typename AllocatorType::const_iterator;

  /** Size and value type alias support */
  using SizeType = ::itk::Size<VDimension>;
  using SizeValueType = typename SizeType::SizeValueType;

  /** Radius type alias support */
  using RadiusType = ::itk::Size<VDimension>;

  /** Offset type used to reference neighbor locations */
  using OffsetType = Offset<VDimension>;

  /** External slice iterator type type alias support */
  using SliceIteratorType = SliceIterator<TPixel, Self>;

  /** Type used to refer to space dimensions */
  using DimensionValueType = unsigned int;

  /** Type used to refer to the elements of the pixel list
   * that are part of the neighborhood. */
  using NeighborIndexType = SizeValueType;

  /** Default constructor. */
  Neighborhood()
  {
    m_Radius.Fill(0);
    m_Size.Fill(0);
    for (DimensionValueType i = 0; i < VDimension; ++i)
    {
      m_StrideTable[i] = 0;
    }
  }

  /** Default destructor. */
  virtual ~Neighborhood() = default;

  /** Copy constructor. */
  Neighborhood(const Self & other);

  /** Move-constructor. */
  Neighborhood(Self &&) = default;

  /** Assignment operator. */
  Self &
  operator=(const Self & other);

  /** Move-assignment. */
  Self &
  operator=(Self &&) = default;

  /** Comparison operator. */
  bool
  operator==(const Self & other) const
  {
    return (m_Radius == other.m_Radius && m_Size == other.m_Size && m_DataBuffer == other.m_DataBuffer);
  }

  ITK_UNEQUAL_OPERATOR_MEMBER_FUNCTION(Self);

  /** Returns the radius of the neighborhood. */
  const SizeType
  GetRadius() const
  {
    return m_Radius;
  }

  /** Returns the radius of the neighborhood along a specified
   * dimension. */
  SizeValueType
  GetRadius(DimensionValueType n) const
  {
    return m_Radius[n];
  }

  /** Returns the size (total length) of the neighborhood along
   * a specified dimension. */
  SizeValueType
  GetSize(DimensionValueType n) const
  {
    return m_Size[n];
  }

  /** Returns the size (total length of sides) of the neighborhood. */
  SizeType
  GetSize() const
  {
    return m_Size;
  }

  /** Returns the stride length for the specified dimension. Stride
   * length is the number of pixels between adjacent pixels along the
   * given dimension. */
  OffsetValueType
  GetStride(DimensionValueType axis) const
  {
    return (axis < VDimension) ? m_StrideTable[axis] : 0;
  }

  /** STL-style iterator support. */
  Iterator
  End()
  {
    return m_DataBuffer.end();
  }
  Iterator
  Begin()
  {
    return m_DataBuffer.begin();
  }
  ConstIterator
  End() const
  {
    return m_DataBuffer.end();
  }
  ConstIterator
  Begin() const
  {
    return m_DataBuffer.begin();
  }

  /** More STL-style support. */
  NeighborIndexType
  Size() const
  {
    return m_DataBuffer.size();
  }

  /** Pass-through data access methods to the buffer. */
  TPixel &       operator[](NeighborIndexType i) { return m_DataBuffer[i]; }
  const TPixel & operator[](NeighborIndexType i) const { return m_DataBuffer[i]; }
  TPixel &
  GetElement(NeighborIndexType i)
  {
    return m_DataBuffer[i];
  }

  /** Returns the element at the center of the neighborhood. */
  TPixel
  GetCenterValue() const
  {
    return (this->operator[]((this->Size()) >> 1));
  }

  /** Sets the radius for the neighborhood, calculates size from the
   * radius, and allocates storage. */
  void
  SetRadius(const SizeType &);

  /** Sets the radius for the neighborhood. Overloaded to support an unsigned
   * long array. */
  void
  SetRadius(const SizeValueType * rad)
  {
    SizeType s;
    std::copy_n(rad, VDimension, s.m_InternalArray);
    this->SetRadius(s);
  }

  /** Overloads SetRadius to allow a single long integer argument
   * that is used as the radius of all the dimensions of the
   * Neighborhood (resulting in a "square" neighborhood). */
  void
  SetRadius(const SizeValueType);

  /** Standard itk object method. */
  void
  Print(std::ostream & os) const
  {
    this->PrintSelf(os, Indent(0));
  }

  /** Returns a reference to the data buffer structure. */
  AllocatorType &
  GetBufferReference()
  {
    return m_DataBuffer;
  }
  const AllocatorType &
  GetBufferReference() const
  {
    return m_DataBuffer;
  }

  /** Get pixel value by offset */
  TPixel &       operator[](const OffsetType & o) { return this->operator[](this->GetNeighborhoodIndex(o)); }
  const TPixel & operator[](const OffsetType & o) const { return this->operator[](this->GetNeighborhoodIndex(o)); }

  /** Returns the itk::Offset from the center of the Neighborhood to
      the requested neighbor index. */
  OffsetType
  GetOffset(NeighborIndexType i) const
  {
    return m_OffsetTable[i];
  }

  virtual NeighborIndexType
  GetNeighborhoodIndex(const OffsetType &) const;

  NeighborIndexType
  GetCenterNeighborhoodIndex() const
  {
    return static_cast<NeighborIndexType>(this->Size() / 2);
  }

  std::slice
  GetSlice(unsigned int) const;

protected:
  /** Sets the length along each dimension. */
  void
  SetSize()
  {
    for (DimensionValueType i = 0; i < VDimension; ++i)
    {
      m_Size[i] = m_Radius[i] * 2 + 1;
    }
  }

  /** Allocates the neighborhood's memory buffer. */
  virtual void
  Allocate(NeighborIndexType i)
  {
    m_DataBuffer.set_size(i);
  }

  /** Standard itk object method. */
  virtual void
  PrintSelf(std::ostream &, Indent) const;

  /** Computes the entries for the stride table */
  virtual void
  ComputeNeighborhoodStrideTable();

  /** Fills entries into the offset lookup table. Called once on
      initialization. */
  virtual void
  ComputeNeighborhoodOffsetTable();

private:
  /** Number of neighbors to include (symmetrically) along each axis.
   * A neighborhood will always have odd-length axes (m_Radius[n]*2+1). */
  SizeType m_Radius;

  /** Actual length of each dimension, calculated from m_Radius.
   * A neighborhood will always have odd-length axes (m_Radius[n]*2+1). */
  SizeType m_Size;

  /** The buffer in which data is stored. */
  AllocatorType m_DataBuffer;

  /** A lookup table for keeping track of stride lengths in a neighborhood
      i.e. the memory offsets between pixels along each dimensional axis */
  OffsetValueType m_StrideTable[VDimension];

  /** */
  std::vector<OffsetType> m_OffsetTable;
};

template <typename TPixel, unsigned int VDimension, typename TContainer>
std::ostream &
operator<<(std::ostream & os, const Neighborhood<TPixel, VDimension, TContainer> & neighborhood)
{
  os << "Neighborhood:" << std::endl;
  os << "    Radius:" << neighborhood.GetRadius() << std::endl;
  os << "    Size:" << neighborhood.GetSize() << std::endl;
  os << "    DataBuffer:" << neighborhood.GetBufferReference() << std::endl;

  return os;
}
} // namespace itk

#ifndef ITK_MANUAL_INSTANTIATION
#  include "itkNeighborhood.hxx"
#endif

#endif

redpajama_set_name: RedPajamaGithub


text:
How To Connect An Apple TV To A Projector: A Beginner's Guide 2023
How To Mirror Your Mobile Screen on Any Wall Without a Projector? 6 Different Options In 2023
Category - Guide
How To Connect Xbox To A Projector? A Step-by-Step Guide
Connecting an Xbox to a projector is becoming increasingly popular, especially with gamers who want the full experience of playing video games on a large screen. Whether you're playing at home or in an office, connecting an Xbox to a projector can be done in three simple steps! This guide will walk you through connecting your Xbox console to...
Guide • Projectors
What Is A Short Throw Projector? All You Need to Know In 2023
Short-throw projectors are a great way to make presentations and watch movies in any size room. They allow you to project images onto a wall or screen from a short distance, making them perfect for small spaces. With so many types of short-throw projectors on the market, it can be challenging to know which one is right for you. This guide will...
How To Use A Projector As A TV? Turn Your Projector Into A Smart TV | Tips & Tricks 2023
Watching TV on a projector is an excellent way to get the most out of your viewing experience. A projector allows you to enjoy movies or shows on a much larger screen than you would with traditional television and can give you a cinema-like experience right in your own home. With the right setup, watching TV on a projector has never been easier...
How To Connect A PS4 To A Projector?: A Step-by-Step Guide 2023
Getting ready for your big gaming night? Are you planning to take the entertainment up a notch and connect your PS4 to a Projector? Fantastic! Connecting a gaming console to a projector is easy, but it can also be tricky. You don't want any hiccups on game night, so make sure that everything's lined up with this complete guide, and get...
How To Connect A Fire Stick To A Projector? All Possible Ways With Troubleshooting & FAQs | Guide 2023
Connecting your Firestick to a projector is an easy and straightforward process that can be completed in just a few steps. With the help of this step-by-step guide, you will learn how to quickly and effectively connect your Firestick device to your Projector for an enhanced viewing experience. Whether streaming movies and shows or playing games...
How To Clean a Projector Screen? Step-by-Step Guide to Cleaning Your Projector Screen: Tips & FAQs
Projector screens are essential to a home theater system and must be regularly cleaned to ensure optimal picture quality. Cleaning your projector screen can seem daunting, but it doesn't have to be! This step-by-step guide will teach you the best tips and FAQs for cleaning your projector screen. From wiping away dust particles to scrubbing...
How Much Power Does a Projector Consume? All You Need to Know About the Power Consumption of a Projector?
The wattage of a projector can vary widely depending on the model and size. A smaller, portable projector may only use around 50 watts, while a more extensive projection system may require hundred or more watts. Knowing how many watts your particular projector needs is essential for understanding its power requirements and the potential cost of...
How Long Does a Projector Lamp Last? All about Projector Lamp Life: Guide 2023
Projectors are popular for business presentations, classrooms, and home theaters. They're convenient, provide a large image size, and don't require additional equipment to create an impressive display. But despite their convenience, one of the most important factors to consider when using a projector —is the amount of time a projector...
Basement Projector Ideas: 9 Creative Suggestions To Consider In 2023
In order to have great fun with a projector in your basement, there are some clever ways that you can set it up; these tips will help make sure you get the most out of this experience. You can do many things with a basement, but one of the most fun and interesting is to set up a projector. This can be a great way to watch movies or play video...
Projector Throw Ratio: Everything You Need To Know About the Projector's Throw Ratio
If you're looking into buying a projector or trying to figure out the best way to set up your current projector, you've probably come across the term "throw ratio." But what is the projector-throw ratio? The throw ratio is the distance between the projector and the screen divided by the image's width. In other words...
Copyright © 2018 ConsumerGuideHub


text:
Sharon Bush wasn't invited to George H.W. Bush's funeral
By Richard Johnson
December 10, 2018 | 9:37pm
Sharon Bush and George H.W. Bush Getty Images
Sharon Bush — ex-wife of Neil Bush — is steamed she wasn't invited to President George H.W. Bush's funeral.
Sharon informed Neil that she hoped to sit with their three children, Lauren, Pierce and Ashley, at the service for her former father-in-law, but Neil's secretary got back to her with the snub, claiming there were not enough pews in the Washington National Cathedral.
"I was going to take the train down. I wanted to pay my respects," Sharon told me. "But I paid my respects by raising three wonderful children during a 23-year marriage."
Instead, Sharon had lunch with Anne Hearst and Cynthia Germanotta, Lady Gaga's mom, during the funeral.
Lauren, wife of Ralph Lauren's son David, has provided 100 million meals through her Feed Bag initiative. Pierce is head of Texas' Big Brothers Big Sisters. And Ashley tutors women in safe houses.
"I taught them everything they know about 'points of light' by taking them to soup kitchens and homeless shelters from the time they were 4 years old. I didn't want them spoiled," Sharon said. "I did this. Neil was never around. He was always traveling."
Neil could not be reached for comment.
Filed under funerals , george h.w. bush , sharon bush , 12/10/18
Marshmello's family connection to eBay


text:
Welcome to the University of Wisconsin Department of Medicine! I'm so excited to share why our department is such an amazing place to learn, teach, discover and work.
It starts with our core values:
Professional fulfillment
Impact in Wisconsin and beyond
These values are the compass guiding everything we do. They resonate in our hearts and propel us forward to fulfill our mission: to develop exceptional leaders who transform the world of medicine through scholarship, innovation and partnership.
And that's how we move ever closer to achieving our vision: health and equity for all.
Here's what it looks like in action:
Individualized training programs that integrate rigorous clinical education, the scholarly opportunities of a top-ten research institution and genuine mentorship by supportive faculty.
Transformative research on health disparities, aging and Alzheimer's disease, tobacco use disorders and other critical health issues that's improving the lives of people in Wisconsin and the nation.
Top-ranked clinical programs that raise the standard of care in our communities and across our specialty.
A place where people strive for equity and justice, act with compassion, and intentionally create an inclusive and safe environment where everyone can thrive.
As chair, my job is to inspire and empower leaders who will challenge the status quo, make new discoveries, and find better ways to work, teach and care for patients.
I'm thrilled to do that on a world-class campus in a wonderful and exceptionally livable city, in a department where excellence and equity march forward together, and with people who are committed to the journey.
Join us, and let's transform the world of medicine together.
On Wisconsin!
Lynn M. Schnapp, MD, ATSF
George R. and Elaine Love Professor
Chair, Department of Medicine
Division of Allergy, Pulmonary and Critical Care Medicine


text:
Crime Watch News UPDATED: Ozubulu Killings: Police Arrest Some Suspects
UPDATED: Ozubulu Killings: Police Arrest Some Suspects
by Admin on 16:34:00 in Crime Watch, News
Some Suspects linked to the killings of worshippers at St. Phillip Catholic Church, Ozubulu, Anambra state on Sunday have reportedly been arrested.
According to Special Assistant to Governor of Anambra state on New Media, Rotr. Ifeanyi Aniagoh, the suspects were arrested today.
The Anambra State Police Commissioner, Garba Baba Umar, has also disclosed that some suspects who masterminded the Sunday's killings have been arrested
Umar told journalists today, Monday August 7th that the number of arrest would not be disclosed so as not to jeopardise ongoing investigation into the massacre of 11 persons by unknown gunmen.
The commissioner had on Sunday said the attack was an isolated case of feud between two individuals from the same community, adding that the police had contacted some persons who would be useful in the investigation.
The Minister of Interior, retired Lt.-Gen. Abdulrahman Dambazau, made the pledge in a statement signed by the Director Press in the Ministry, Willie Bassey, on Monday in Abuja.
The minister condemned "in strongest terms" the killings and assured that all hands will be on deck to bring the perpetrators to justice.
PHOTOS: Priests Abandon Church Built By "Bishop," Celebrates Mass In Uncompleted Building
Labels: Crime Watch, News


text:
Jesuitical Drug Policy Treason
From my unpublished manuscript "Coca Forgotten Medicine"
A Foreign Military Order's Un-Constitutional Rule & Treason to Humanity through the Jesuit Order Run Georgetown University, the U.S. State Department and the National Institute [for promoting] Drug Abuse
The allegiance to the drug control status quo was prevalent from the onset throughout the Clinton Administration's bureaucracies, as has been the case with either the Democrat or Republican Parties throughout the 1900s. I found it typified by two Washington, D.C. meetings held on successive days in July 1993, some 6 months into the then new Clinton Administration, with the official presentations and responses at the Q&A sessions indicating how truth was beholden to this false ideology.
The first of these events was a plenary panel organized by the U.S. State Department and the like-wise Jesuit Order run Georgetown University Center for Strategic and International Studies. The second one was a workshop panel held during the multi-day conference by the National Institute of Drug Abuse (N.I.D.A.).
The State Department-Georgetown University event was titled "Multilateralism and Drugs", and was held July 15, 1993 at the Rayburn U.S. House of Representatives Office Building. Its speakers included Yale University's David Musto, and Timothy E. Wirth, U.S. President Clinton's appointee as Undersecretary of State for Global Affairs.
David Musto
At this event, Musto admitted a fact that he would leave out of his Readers' Digest style articles: that dilute cocaine alkaloid containing Coca beverages such as Vin Mariani, were not problematic.
Wirth, previously a U.S. Representative and later a Senator from Colorado, was described as the Clinton Administration's point man on everything from refugees to global warming, and described in glowing terms by newspapers such as The Washington Post, as a "reformer", was there to give a speech titled "New Approaches to Global Drug Problems". So I figured that he would be a good person to ask about the Coca issue, which I did at that panel's Q and A period:
Douglas Willinger- Question: Sir, you mentioned crop eradication -- Coca eradication -- as the solution but have you consider the alternative. Instead of crop substitution, why not cocaine conversion- that is, remove the things creating this bad situation, having coca tea in supermarkets rather than crack in the streets. Indeed, sir, what about Bolivia's recent proposal to review the effects of Coca, and adjusting the laws accordingly if need be?
Timothy Wirth- Answer: Did I talk about crop eradication? Do I have to answer that? You sound like one of those Hemp people! Next question.
The NIDA event, a workshop panel Update on Drugs- Cocaine and Stimulants, was held at the second day of the U.S. N.I.D.A. National Conference on Drug Abuse Research and Practice; An Alliance for the 21st Century. It featured a number of speakers, including a Dr. Millwood, all testifying to the dangers of cocaine. One of the presenters spoke about brain damage with combined cocaine and alcohol use, including its metabolization of cocaethyline. All in all, while their prognosis upon cocaine was negative, I heard little to no mention of actual doses. From memory, as NIDA is uncooperative with public requests for such transcripts:
Douglas Willinger- Question: Question of dosage and paradigm. You speak of the dangers of cocaine and alcohol, but could you please elaborate as to the dosages? What stimulant would not be harmful in such does? Is cocaine itself anymore toxic as asides from the concentrated forms as developed under prohibition.
Dr. Millwood- Answer: About 1 ¼ gallon of vodka and an eight ball of pharmaceutical grade cocaine hci snorted in one night. Well, uh yes, we just don't think it's that important, let's change the subject, okay?!
In other words, cocaine was a highly toxic-addictive drug in doses dangerous with any stimulant. They had no showing that it was anymore toxic then other naturally occurring stimulants caffeine and nicotine, in like contexts. Cocaine, Caffeine and Nicotine are all alkaloids that serve as CNS stimulants found in minute amounts in such plants as Coca, Coffee and Tobacco.
As licit drugs, they are taken through the use of the parent substance, or in isolated form in a mode of delivery of a pharmaceutical preparation, e.g. caffeine as No Doz or Vivarin tablets largely consisting of mannitol, and more recently various nicotine chewing gums and patches.
As an illicit drug under a prohibition of Coca leaves and cocaine, with penalties based upon the contraband's gross weight, the amount of cocaine use is significantly reduced, but the amount of cocaine taken per dose may be higher, with the concentration definitely far higher in doses of the type more akin to produce the big bang favored by these drug law's economics, with prohibition driving up concentration and prices hence promoting the justification for the price- e.g. spending $50 or $100 for a chewing gum package sized foil of white powder is more justified by the pronounced effects of doses that are more dangerous in every way: larger more concentrated and more direct.
And this is popularly supported as somehow fighting drug abuse!
Such a drug policy regimen that suppresses a safer substance for the sake of a one intrinsically dangerous, that is the adulterated, misbranded cigarettes undeniably benefited by this criminal mercantilism, underwent no visible criticism within the room where Mr. Wirth brushed aside my question. This was also so in the room where Dr. Millwood would answer my question about the amount of cocaine needed to produce the toxicities he discussed, but not answer my second question about the silence in the drug abuse research industry over maintains the drug control policy that stops Coca while promoting concentrated cocaine. One could only imagine if either Wirth and Millwood, nor the U.S. State Department and the U.S. Department of Health and Human Services N.I.D.A. had even given any thought about whether such anti-Coca leaf policies were reconcilable with any stance respecting either the public's health, let alone the human rights of the millions of Andeans who consider Coca eradication an infringement upon their individual and their cultural rights, in this day and age of moral certainty. I suppose they simply care less for that then appeasing their masters that gave them their jobs.
Georgetown University's Jesuit Order's Underappreciated 20th Century Role
Labels: Coca Forgotten Medicine, David Musto
1988 DEA Administrative Judge Young
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A True Explaination
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First Listen Reviews: The Lumineers, Cathy Jordan, Little Richard, and Admiral Fallow
Kim Ruehl Posted On April 10, 2012
THE LUMINEERS – Self-titled
Everyone loves the Lumineers, so there's some expectations on this one. Initially, I don't think they sound particularly different from everything else that's happening these days. There's a Dylanesque kind of thing going on with the lead singer's voice. The second song ("Ho Hey") employs a "HEY!" that sounds like it was lifted straight out of "Don't Come Around Here No More." But then it picks up and something happens. My foot is going, my head. My torso is doing a little sway and pop, and I don't even know why. Like I said, it's not particularly unique or individual. But it does that thing music should do – gets inside me somehow, without me even knowing how or why. I want to crank it loud and drive all day. I want to park it on the beach and build something in the sand; throw some meat on a grill and kick back. Whatever it is, I can't stop listening. I'm not going to try to pretend it's got deep, lasting artistic value, but with grooves this good, who cares. It's perfect for summer in the background, and I bet their live show is fun as hell too.
CATHY JORDAN – ALL THE WAY HOME
Right off the bat, Jordan's voice proves soothing and full of whispy depth. I tend to enjoy traditional Irish music more in theory than in practice. I rarely find myself in a "traditional Irish folk music" mood, but there's something about Jordan's approach to the form which is stirring and perhaps even a bit more contemporary. Perhaps it's the instrumentation or the way the melodies lilt off her tongue – there's something sleepy about it. Not exactly tentative or lazy, but wanting. Lonesome. Possibly even regretful, without being morose. I don't know how to explain it, but I'm several songs in and still falling over the words, so maybe this is one to pull back out a few more times before I can properly wrap my head around it. It's certainly something that should interest more trad folkies than me, but also won't scare off the more contemporary indie roots folks. It's all nighttime rain and stargazing, maybe even with whiskey.
HERE'S LITTLE RICHARD (Remastered)
This feels a little like cheating, far as the implications of a "first listen" go. Lord knows I've heard most of these songs a million times and this is a reissue. Honestly though, if not for a reissue, I may not think about listening to Little Richard this year. The man is a national treasure and listening to this classic album (all remastered for our digital ears) is a reminder of what music feels like when, to borrow a phrase from Grant Alden, it swings. I'd say ninety-eight percent of the music happening these days couldn't possibly stand up next to the Little Richards of the world (as if there's more than one). This is the kind of energy, passion, and straight-up music toward which songwriters should be shooting. If, in the middle of the constant indie din, you need a reminder of how it feels to hear someone sing the crap out of something, this is where you should go. Besides, it includes a couple of demos at the end, two videos, and an interview with Specialty Records founder Art Rupe. And a poster. Yes, a poster, for your wall.
ADMIRAL FALLOW – TREE BURSTS IN SNOW
I should have eaten a strawberry, or something, between Little Richard and this one. Cleared my palate, if you know what I mean. This is not music for the same reasons as, say "Tutti Frutti." This is moody indie soundscape kind of music. There are a few awkward phrases repeated over and over, which aren't very intrinsically musical. When I hear bands do that I consciously wonder if they're being intentionally awkward or if they just don't understand that words have musicality…sometimes they really can work with the notes you're singing; other times they work against the music. Sometimes the music is so artful, I'm fairly certain they're deliberately putting the lyrics in opposition to it. Sometimes, it's not clear what they're going for. In the spirit of art, I'd like to think that's deliberate too, but often I doubt it. So, here I am considering this tiny little aspect of the music far too existentially when the second song comes on and it's kind of what I imagine would happen if the Head and the Heart tried to channel the Arcade Fire. It's not effective. I bet these guys are exciting live. I'm not sure they should be completely judged on how they translate that to a studio recording, though. There's something about this album which feels like they're trying too hard and not truly feeling it. I bet they'll be much better at the whole album thing in five or six years. (If albums are still a thing at that point.)
Capercaillie – Scottish roots
By NO DEPRESSION on November 30, 2013
Americana Boogie new releases for the week of Nov. 26th… Billie Joe & Norah do the Everlys, Beachwood Sparks, Guy Clark
By Erik Larson and Peacemaker on November 27, 2013


Ok, this is a first for us, but it's something we'd like to do more of. We'd like to start showing other people's videos as well.
Yes, we'll still be posting our own videos, but there are lots of awesome videos being produced about South Korea that need to get more recognition, we think. This is the first video we've seen that has moved us to post other people's videos on this site. Quite frankly, it's one of the best short videos we've seen promoting South Korea, ever. Like, ever. I wish Korea Tourism hired this guy. Enough videos about Bulgogi and Bibimbap. Enough visit Dokdo ads. This video is much more moving than all of those videos, and we'd love it if the official promotional forces of Korea started taking this direction.
It's kind of what we've always been interested in when it comes to talking about South Korea. Korea is cool, really cool, but it doesn't seem that way from the ads we've seen for it. Traditional, fuddy duddy stuff that smack of "Korea is the Best!" is just boring. South Korea isn't really advertised from an outsider's perspective. A lot of the time it's shown through a Korean person's perspective, and – as a result – it seems that what's interesting to Koreans about Korea isn't interesting to foreigners about Korea. At least, that's our position. Table bells, nose rollers, and other Wonderful Treasure Finds still make us say wow, show us that Korea is fun and quirky and cool, while our Korean friends just think of them as commonplace and boring. Pshaw!
And, yes, yes we know this is a bit of a serious post compared to the silly videos that we usually do, but – really – we wish we could make videos half as good as this one here. We're gonna keep on trying to make artsy-fartsy videos every so often, so that we don't fully go totally off the deep end into Kpop and WTFs. So, with that being said, check out David Duttons' Vimeo Page for more awesome videos, and check out his website as well. Also, let us know if more videos like this is something you'd be interested in seeing or not, if we should keep this site for only Eat Your Kimchi videos. Be honest. We're totally open to other people's opinions. Fact is, we've been thinking about showing other videos for a while now, and still haven't fully decided on it yet, so we're dipping our toes in the water now. And finally, if there are any videos you'd like us to share in the future, send us an email! Yeah!
This video only makes me wanna go and experience South Korea more! All my friends don't get it but this video does a good job of explaining and showing the awesome things!
pls pls pls if u know the name of the songs used in this video……..and yes the video is amazing!!!!
Chemical Brothers – The Pills Won't HelpYou Now.
The second song I will figure it out when I get home.
People often ask what it is that I love about Korea. It's not easy to explain. This video captures it better than just about anything I've seen or read.
It made me so wistful and wishing I could be there. You guys are super wonderful to share all that you do. I think it's a great idea to promote others video's of Korea. It is such a beautiful place. Sometimes seemingly more pure that all others.
Goose bumps…….Amazing video. I like it a lot!!
WOW~ this is so amazing! i love how it shows the BEAUTIFUL scenery while still showing some of the old korean cultures.
Judging by your website address, you wouldn't happened to be related to him, would you?
Actually, this is a misconception. The decision to choose the current head of the KTO, Charm Lee, came after a careful consideration of his potential to bring eclecticism and a non-Korean's fresh perspective to the post. Tourism has become a very important issue in South Korea in the past few years, with nation branding also becoming a large concern for the government due to the Western media's disproportionate focus on North Korea. It's not that "Koreans don't really care about promoting their country" – this is, in most cases, the complete opposite. Still, we have to realize that the bulk of South Korea's tourism campaigns are directed towards other Asian nations (Japan, China, SE Asia, etc.) and in this regard, they've been pretty successful. It would be nice, however, if there were more adverts (better and higher quality ones, like this video) aimed toward a Western audience.
@Simon and Martina: Thank you for the wonderul video; it's a great, refreshing addition to your blog and I wouldn't mind more videos like it!
I really enjoyed it a lot. It was nice just watching and seeing what the individual filming was and how they viewed everything going on. I would love to see more video's like this.
This is a really great video….
would like to know more about Korea so would want to watch more videos like these…………..
thank u for the video….
I was thinking the same thing as you while I watched this video.
They should hire him to promote tourism!
From the bottom of my heart thank you for posting this.Seriously, I am so in love with this side of Korea that the short film presents.It's simply another reason for me to learn Korean and get there.In the mountains, in Seoul, everywhere in S. Korea.So thanks.And whenever you find another breathtaking video like this one please do share it.Have a lovely weekend!
This video is really beautiful. I definitely wouldn't mind more videos like these on your site. However I hope it wont stop you making videos. While these videos are really beautiful, I love you way of presenting Korea, the different holidays, your everyday life, I feel I'm going to be addicted to your WTF videos just like I already am to you Kpop Mondays ones. If on your site I can find both quirky and more artsy videos I'm all for it!
I loved this video, but do I want to see lots more of the same? Well, honestly, no. What I like about the videos you two make is that they have a really quirky and homey feel about them. I like to see what you guys love about living in South Korea and seeing it through your eyes. I don't even live in South Korea and I still enjoyed your video about how to make the floor heating work because I thought that was so neat and different! The problem with videos like this one you shared is that while beautiful, it feels very detached. I don't really feel like I learned anything about South Korea besides that it is a beautiful place. Even when you two do your more artsy videos it has a focus and has a point of view. You showcase specific temples, markets, even the train ride from Busan to Seoul I liked because it was specific like that.
So I guess what I'm saying is that I would like to see other videos as well, but personally (just my opinion!) I would like to see more videos with a point of view or that showcases something specific that's really cool in South Korea, not just more catch all videos.
I think it's great that you've decided to start posting other videos that you guys have found interesting~ especially because I've seemed to enjoy them all so far! This video was awesome, it makes me want to go to Korea x24810348 more than I already do, and that's a hunk of wanting right there!
All of the latest tourism videos seem to push the main-stream American crowd – i.e. Lettuce-wrap restaurants, Hanbok and all of the other cliches.
Japan has become so popular because of all of its quirkiness and oddities.
I think Korea has a can't-miss opportunity to become the next "Japan" (culturally speaking)… with the big difference being that Korea can do it in a uniquely dignified Korean way. This video exemplifies this, I think.
I'd like to see more work done in this manner.
You know, that was on the tip of our tongues as well. Japan is such a hit because it seems so quirky and bizarre, and so people are intrigued by it. I think Korea takes itself too seriously a lot of the time, and doesn't show off it's quirks, which is a shame, because Korea's really freaking cool. Yeah!
That was a beautiful video I do think you should maybe once a week show a different video like this one, dont get me wrong I love your guys's videos but I dunno it was a refreshing change. And besides the goal of your website is for others to know about korea and that includes South Korea too. So thank you for sharing I definitely want to visit Korea someday.
So beautiful – Dutton is so talented. This film visually explains why I have been obsessing on South Korea and want so much to visit there. Creativity blossoms when so much is offered.
What an outstanding video and such a beautiful country. I will visit in July. Do post more of these videos. Much of what I know of Korea is from addictively watching Kdramas.
i reeeeeaaaallly loved this video.. gonna check out his page now.
First I was reading comments and everyone liked this video, but I was doubting that I will like it.
I moved to Korea two months ago and all i can say that it's breathtaking.
I loved this video so much! it must have taken a long time to get all that material, i've already started collecting short clips around Seoul and this summer i hope to get more from all over Korea, this country is wonderful!
lovely video. thanks for sharing. Do you know the name of the song that's playing for most of the video?
I've got no clue what song it is, but I'd love to know. It's awesome.
Very interesting. Where are the places they went in the country? It was beautiful.
Okay…the last song that sounded like they were saying "popsicle"? What does that word mean in Korean?
This is wonderful! I totally agree with you. This is an awesome way to promote South Korea. It makes me even more interested in it and I hope one day i'll be able to visit some of those places.


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IndustriALL Charter of Solidarity
IndustriALL Global Union's Charter of Solidarity in Confronting Corporate Violations of Fundamental Rights
IndustriALL is a global trade union representing more than 50 million manufacturing, energy and mine workers in some 140 countries. We are committed to defending and furthering the rights of workers all over the world and engage in a wide array of activities in pursuit of that goal.
IndustriALL's Action Plan adopted at its Founding Congress gives a mandate to:
- Take responsibility for the respect of union rights and decent working conditions throughout their supply chains
- Develop further a MNC network strategy for exchange of information, joint initiatives,common platforms, coordination of national collective bargaining and mobilization in case of violations of workers' rights by MNCs and their suppliers
- Establish mechanisms of regular social dialogue at global and/or regional level to enable constructive industrial relations leading to global level negotiations
- Build up the necessary organizational procedures to enable the conclusion of agreements beyond GFAs with MNCs
One of our key areas of focus is multinational companies (MNCs), and IndustriALL Global Union represents millions of workers in thousands of MNCs. Multinational companies also account for around 70% of world trade, and are without doubt critical in defining and shaping the global economy in which we live and operate today.
Given their power and influence it is essential that MNCs operate in a manner that respects and promotes human rights, including workers' rights wherever they are present, in particular in relation to the Core Labour Standards as defined by the United Nations' International Labour Organisation (ILO), namely;
The right to organise and belong to a trade union – ILO Convention 87;
The right to bargain collectively – ILO Convention 98;
A commitment not to use Forced or Bonded Labour - ILO Conventions 29 and 105; A commitment not to use Child Labour – ILO Conventions 138 and 182;
A commitment to non-discrimination – ILO Conventions 100 and 111.
Furthermore , with the adoption of the UN's Guiding Principles on Business and Human Rights, and the reference to them in the OECD's Guidelines for Multinational Enterprises, there is now less of a distinction between the ILO's Core Labour Standards and all of its other standards , including the ILO's important occupational health and safety instruments (eg. ILO Convention 155, the Occupational Safety and Health Convention; or ILO Convention 176, the Convention on Safety and Health in Mines; among others). IndustriALL Global Union expects MNCs to act affirmatively to uphold all human rights standards, including all of the instruments and standards of the ILO, and not just the core labour standards.
Under these new Principles and Guidelines, MNCs are responsible for avoiding adverse impacts and must exercise due diligence in ensuring this through their value chains and business relationships, and within their spheres of influence.
Although some MNCs abide by these standards and have even signed Global Framework Agreements (GFAs) with IndustriALL Global Union to give credence to their commitments, there are still companies that have not and that adamantly refuse to do so. More worryingly still, there are
also companies that have signed such agreements and then do not abide by the commitments they have given. In some cases these companies do recognise unions and behave with respect towards the workforces in the countries from which they originate, and then behave in an anti-union and abusive manner towards workers in other countries where they are present.
IndustriALL Global Union entirely rejects the notion that companies may behave properly where they are headquartered and then refuse to adhere to the same standards elsewhere. Furthermore, IndustriALL Global Union utterly rejects the idea that companies that are parties to GFAs having given commitments to observe and abide by Core Labour Standards, but then totally ignore those commitments when they deem it expedient to do so, whether under the pretext of adhering to national laws or for any other reason.
- To this end IndustriALL Global Union and its affiliates have committed to taking the following actions when the Secretariat receives notification from an affiliate that an MNC in its country is violating human and Core Labour Standards:
- Upon being notified of an MNC infringing human and Core Labour Standards, IndustriALL Global Union secretariat will contact the union in the country where the MNC is headquartered, if one exists, to solve the problem.
- IndustriALL Global Union will, where appropriate, seek to arrange a meeting with the central management of the infringing MNC urging it to solve the issue. IndustriALL Global Union will inform and involve the relevant affected union(s), the union(s) representing workers in the country where the MNC is headquartered, and other relevant affiliates;
- Should the MNC not agree to take immediate steps to rectify the problem, IndustriALL Global Union will notify all affiliates and coordinate a series of actions to bring about pressure for the MNC to amend its actions. These measures may include:
A meeting of affiliates with members in the company concerned to produce a detailed overview of the situation;
Media actions to notify the widest possible public of the infringements of workers' rights – both in the country in which the offending MNC is headquartered as well as the countries in which it operates;
An examination of the possibility of industrial action and demonstrations in support of the affected workers and their union;
Appropriate legal actions before ILO bodies, the OECD, regional human rights bodies and forums established under trade agreements.
The production of a detailed leverage strategy designed to rectify the situation;
At all times affiliated unions will seek to ensure that member activists and representatives are fully involved and take ownership of the action plans being developed. Strategies that put members and their representatives at the heart of the activities will be considerably more effective in achieving the desired outcomes.
IndustriALL Charter of Solidarity (English)
IndustriALL Charter of Solidarity (French)
IndustriALL Charter of Solidarity (German)
IndustriALL Charter of Solidarity (Japanese)
IndustriALL Charter of Solidarity (Russian)
IndustriALL Charter of Solidarity (Spanish)


Aliens land on a small mountain where Yobi - a five tailed fox with the ability to transform - lives alone, and decide to live with her. 100 years into the present: the aliens are ready to leave, but one of the clumsy aliens accidentally causes the launch to fail and runs away after being scorned- putting himself and the group in jeopardy. Now, Yobi and the aliens attempt to rescue him from small children and an a fox hunter. Yobi, The Five Tailed Fox is a visually-stunning, heartwarming, and very entertaining animated film.
The story in this film is great. It is able to be an entertaining and meaningful story. It packs plenty of heartwarming humor through its clean, witty dialogue, and the minor actions of the characters, like the aliens mimicking each other, an alien using his hands as binoculars, or the aliens showing love through slaps. It also has some thrilling action, mostly through some great chases. I found the film to be very positive, emphasizing the proper treatment of each other; souls taking care of souls. And, its interpretation of the afterlife was also positive, interesting, and genuinely beautiful. However, the Yoyo aliens weren't fully developed; as in, they aren't fully utilizes and it often feels like they take the backseat. The ending of this film is magnificent, being truly bittersweet. I liked all of the main characters, Yobi being an incredibly delightful lead - and enthusiastically voiced by Ye-jin Son - and the Yoyo aliens being quirky whenever they had screen time.
The style in this film is beautiful and atmospheric, adding to its charm. The colors are vibrant, the character and settings are excellently designed. The film is great on the eyes. I can't put my finger on it, but most animated films don't use this exact style - Yobi really develops an identity of its own through its style, as well as its story. This is a film I truly hope receives a domestic, or at least region-free, Blu-ray release. The voice acting was perfect for all of the characters, and the music was superb.
Overall, Yobi, The Five Tailed Fox is a magnificent animated film, entertaining for any age group, and perfect for families. It's beatifully animated, perfectly scored, and enthusiastically voiced - with a genuinely heartwarming story. This is another stunning film from South Korea, among many more; don't miss out.
Just an update, Netflix stupidly removed the film from streaming. I'm not sure when exactly. I know I watched it recently.
Yeah, it's very disappointing. I remember Netflix lost a bulk of their amazing Korean lineup in July. Now, they have one of the weaker lineups compared to other streaming services. Hopefully they get more Korean films, I would love to watch this again in HD!


Always handle onions with care. Do not drop onions as this often causes bruising and internal decay.
Bagged or boxed onions should be stored at least 30cm away from walls and other pallets to allow proper air movement.
Store onions in a cool, dry, well-ventilated area.
Maintain storage temperature of 7 – 13°C.
Do not wrap onions in plastic or store in plastic bags. A lack of air circulation will reduce shelf life.
Onions should feel firm and dry, be free of grey or black mould, and should not have any visible sprouting. Some loose skins are normal.
Do not store onions with potatoes or other produce items that release moisture.
Keep onions out of direct sunlight and other heat sources.


After years of development, the National Association of Landscape Professionals (NALP) has launched the Landscape Industry Accredited Company designation. As Landscape Industry Certified is the mark of excellence for individuals in the industry, the new Landscape Industry Accredited Company designation is the mark of excellence at the company level.
A Landscape Industry Accredited Company differentiates itself from the competition and its employees share in that mark of professionalism. Accreditations and certifications help in the bidding process, help attract top employees, and help clients understand that the accredited team is well educated and trained on the latest best practices, according to the NALP.
In compliance: complies with state, local, and federal codes, statues, and licensing and insurance requirements.
Upon approval, Landscape Industry Accredited Companies will receive a certificate, rights to use the Seal of Approval, and marketing materials to help promote their company accreditation.


Rest of the photos: Tyra photo, Aimee, Anya, Dominique, Fatima, Katarzyna, Marvita, Stacy-Ann and Whitney. On the images above are Claire Lauren and Amis.
Why amis had to go ?
i wish they had going home the fugly Fatima!
Jay manuel totally stole this idea from Steven klein, Shame on YOU Jay!!!!!!


Axicabtagene ciloleucel turns a class of the patient's immune cells into veritable «living drugs» that destroy the tumour cells with extraordinary efficiency. This technology fits into the so-called "immunotherapy" (1).
Ari Belldegrun, who studied in Israel, where he did his initial clinical training, joined as a fellow of Steven Rosenberg's working group at the National Cancer Institute in 1985.
During that same month of June, a contractor from Florida, Eric Karlson, suffering from a non-Hodgkin lymphoma, became the first patient treated with what would become KTE-C19 gene therapy. Even though his non-Hodgkin's lymphoma was terminal, the patient is still alive and without a trace of malignant B-cells even today (2018). The National Cancer Institute did not patent KTE-C19; instead, it reached an agreement with Kite Pharma, whereby the laboratory would complete pre-clinical research, and conduct a clinical trial prior to the request for authorization by the US Food and Drug Administration.
The pharmaceutical industry competes to develop new forms of immunotherapy. The first anti-cancer treatment based on the modification of the patient's T-cells to make them competent in the fight against the tumour, was authorized in August 2017, for acute lymphoblastic leukaemia. This first gene therapy was marketed as Kimriah® (Tisagenlecleucel) by the Swiss multinational, Novartis AG. The cost of treatment with Kimriah® is $475,000. This laboratory assumes the cost of treatment if the patient's response does not meet expectations. In addition, Novartis AG hopes to expand the use of Kimriah® (Tisagenlecleucel) to other types of haematological cancers. The extension of these uses should result in a decrease in the price of the therapy.
For the time being, Kite Pharma also plans to apply for the authorization of Yescarta® (Axicabtagene ciloleucel) for non-Hodgkin's lymphoma in its early stages, but does not foresee a reduction the cost of its therapy.
Initially, 54% achieved complete remissions, that is, their tumour «disappeared». Another 28% of patients showed partial remissions, meaning that the tumours had retracted, and their activity (determined by the activity of specific «markers») decreased. After 6 months of treatment, 80% of the 101 patients who received Axicabtagene ciloleuel were still alive.
The study was conducted in two North American hospitals: Dana-Farber Cancer Institute, and Brigham and Women's Cancer Center, both in Boston, Massachusetts. To get an idea of the situation, some patients joined the study from the hospices where they received only palliative care.
The treatment requires the removal of millions of T-cells from the patient. These cells are frozen and sent to the laboratory (Kite Pharma). There, they are genetically reprogrammed by «teaching» them to attack B cells that have become malignant («non-Hodgkin B-cell lymphoma»). The genetically modified T-cells (designated as CAR-T, Chimeric Antigen Receptor-T-cells) are frozen again, forwarded to the hospital, where, once thawed, the patient receives a single infusion. The preparation times of this individualized therapy have been optimized up to 17 days. The reduction of this time interval is a priority because it is terminally ill.
The laboratory's T-cell processing centre (Kite Pharma), located in El Segundo, California, is adapted to prepare individualized treatments for 4,000 or 5,000 patients each year. Likewise, the laboratory plans to shortly apply for the authorization of Axicabtagene ciloleucel (Yescarta®) in the European Union.
López-Tricas, JM., Álvarez De Toledo Bayarte, A. Inmunoterapia, conceptos básicos (spanish). BIFAR (Pharmaceutical Information Bulletin of Aragón) – Scientific Section – 2017; 129: 25-27.
López-Tricas, JM., Álvarez De Toledo Bayarte, A. Immunotherapy for the Treatment of Cancer (approved for publication under the section «Special Article» in the 1st issue of the European Journal of Clinical Pharmacy, January-February 2018).
Fu Y., et al. Medicinal Chemistry of Paclitaxel and its analogues. Curr Med Chem 2009; 16 (30): 3966-85.
Deeks ED. Darunavir: a review of its use in the management of HIV-1 infection. Drugs 2014; 74 (1): 99-125.
Ryam C.J., et al. Abiraterone in metastatic prostate cancer without previous chemotherapy. N Engl J Med 2013; 368 (2): 138-48.
López Tricas, J.M., Álvarez De Toledo Bayarte, A. First Gene Therapy against Lymphoblastic Leukaemia. European Journal of Clinical Pharmay 2017; 19 (4): 227-229.
López Tricas, J.M., Álvarez De Toledo Bayarte, A. Approval of New Drugs. European Journal of Clinical Pharmacy 2016; 18 (5): 291-293.


Next on planet5D Live – Monday October 17th – Author of "Canon 7D: From Snapshots to Great Shots" (read our review) and "Food Photography: From Snapshots to Great Shots" (and others) Nicole S. Young Please join us for this live conversation where you get to ask the questions.
Who is Nicole you ask?
Nicole S. Young is a full-time photographer specializing in commercial photography, and she licenses many of her images through iStockphoto and Getty Images. Nicole is an accredited Adobe Certified Expert (ACE) in Photoshop and a Help Desk Specialist with the National Association of Photoshop Professionals. The author of Canon 7D: From Snapshots to Great Shots and Canon 60D: From Snapshots to Great Shots, she blogs at nicolesyblog.com.


text:
Eleven Seven Records
From Ashes To New
Lancaster, Pennsylvania is one of a hundred similar American towns; in fact, there are places just like it all over the world: post-industrial but still largely working class, and generally offering bleak prospects for the kids who grow up there. Suburban boredom, broken families, substance abuse, limited opportunity – this is an environment in which authentic, compelling creativity can thrive, if it's accompanied by a burning desire, unstoppable drive, and complete lack of any backup plan. There have always been powerful voices that rise above the din of mediocrity and monotony. The voice of From Ashes to New founder and frontman Matt Brandyberry is one of those that is forcing itself to be heard.
Matt's lifelong interest in music progressed along a wide-ranging path: he was ardent hip-hop fan who wrote rhymes while in junior high, then learned piano and guitar. He pursued music with a passion, ignoring warnings from naysayers around him who shook their fingers in disapproval, asserting that he was doomed to fail and would never amount to anything.
His early musical efforts were straight-up rap, and he couldn't get anything happening with it. "People would say, 'You aren't a rapper. You are white. Just quit. Just get a real job.' And I eventually thought I would be that regular 9 to 5 guy."
Yet with major tours with the likes of Hollywood Undead under their belts,and a record deal that puts them among some of the best known commercial rock bands already signed, FATN look set to take their message to a bigger stage than they could ever previously have imagined.
Blessed with honesty, integrity, grit, determination and, most vitally, a genuinely devastating arsenal of gut-mangling tunes – FROM ASHES TO NEW have got all the ingredients to turn your world, and the entire scene, on its head.
❮ JMBLYA Festival Forever Umbrella ❯
2017 © Makadent. All Rights Reserved.


Doki Doki - The Manchester Japanese Festival is a unique event celebrating both traditional and modern Japanese culture.
The first Doki Doki Festival was held in Manchester on Sunday 13 November 2011 and attracted 1,600 visitors.
At the 2011 festival, there were talks, demonstrations and parades showcasing manga, anime, fashion, martial arts and other arts from Japan's past and present, as well as retail stalls, artist stands, a cinema room and games area. Hot and cold Japanese food from a number of local retailers was also available to festival goers.
We're aiming for the 2013 festival to be an even bigger event!