The cost of study abroad varies among different programs based on the cost associated with traveling to a specific location, the duration of the program, the sponsoring institution, etc. The good news is that there are several financial resources available to you; you just need to dedicate some time to inquire about your options.
Below you will find important information about some of the financial resources that may be available to you. Please be aware that eligibility requirements for the options discussed on this page are varied, and several of these resources do not extend to study abroad tuition and fees.
Texas State University is committed to the diversity of people and ideas, inclusiveness, and global perspectives. Student global engagement can be achieved through study abroad programs, which is a great way to connect Texas State students with the world.
The purpose of the Underhill-Kens Scholarship is to enable students with limited financial means to study abroad.
Eligible candidates must be in the "committed" status in their Texas State study abroad program by the scholarship application deadline.
Must have a 3.0 GPA for undergraduate students and a 3.5 GPA for graduate students and be in good standing with Texas State University.
Must be a full-time student preceding the semester of travel (12 hours for undergraduate or 9 hours for graduate students).
Students must have demonstrated financial need (the selection committee may consult with the Financial Aid and Scholarships Office to help determine applicant's financial need).
Preference will be given to students who have had limited or no travel abroad experience.
Students can be undergraduate or graduate students with a preference given to upper classmen undergraduates.
Preference will be given to students participating in programs that will spend a minimum of four weeks abroad.
Students from all disciplines may apply, except for those majoring in the McCoy College of Business.
Upon completion of their study abroad programs, recipients of these funds will be required to submit a report detailing what they learned from the experience and make a short presentation.
Scholarship awards may vary from student to student, however the minimum award will be $2,000 per student.
Awards will be given to the best-qualified applicants as determined by the selection committee.
Awardees will be notified by April 15th, 2019. Funds will be disbursed 10 days prior to the start of the upcoming study abroad program.
Two $1,000 scholarships will be awarded to student at colleges and universities in Central Texas who are planning to study abroad.
"Join us in our mission as "GlobalAustin promotes opportunities for the Central Texas community to experience global, cross-cultural exchange."
Financial aid is usually applicable toward the required costs of approved Texas State study abroad programs, including Faculty-Led programs, International Exchange programs, and Affiliated programs. Please note that there is no guarantee that a student will receive enough financial aid to completely cover the total costs of the study abroad program. Please contact the Texas State Office of Financial Aid and Scholarships to inquire about specific disbursement dates since they depend on your program and type of financial aid. Students should begin investigating the funding options for study abroad, including grants, personal savings, scholarships, and loans, as soon as possible.
Please note there are limits on the number of hours that may be taken via extension studies, which includes study abroad courses. Texas State students may take up to thirty credit hours via extension studies.
Courses abroad must count towards your degree plan in order for you to receive financial aid. Please visit Financial Aid's website here for more information. This page is designed to assist you with your questions on the federal Courses Counting Toward Degree requirements. Your financial aid will be calculated based only on the number of hours for which you are enrolled and count toward your degree.
Students must be enrolled as a full-time student to be eligible for financial aid disbursement (Pell Grant will disburse with less than half-time enrollment).
Federal loans for study abroad programs are disbursed in two equal disbursements. The first disbursement is scheduled 10 days before the program start date, and the second occurs at the program midpoint.
The mission of the Study Abroad Program at Texas State University is to provide students in all areas of academic interest and levels a variety of educational choices abroad. The International Education Fee (IEF) funds the International Education Fee Scholarship program and assists in that mission by making funds available to qualified students who want to study abroad. The 72nd Texas State Legislature passed the IEF Bill, giving authority to the governing boards of all higher education institutions to charge and collect a $1.00 fee from all students who register each semester or summer session. Texas State University began collecting the fee in the 1992 fall semester and was approved to raise the fee to $3.00 starting in the 2002 fall semester.
The IEF Scholarship is distributed in a competition open to all undergraduate and graduate Texas State students who meet the established eligibility requirements. To be eligible, undergraduate students must be enrolled at least part-time at Texas State with a minimum cumulative Texas State GPA of 2.75. First-semester transfer students must have an admission GPA of at least 2.75. Graduate students must be enrolled at least part-time at Texas State with a minimum cumulative Texas State GPA of 3.25. Each applicant is required to be enrolled full-time in Texas State faculty-led, exchange or affiliated study abroad program, unless otherwise stated in the inter-institutional agreement or specified by the program requirements. International students at Texas State, like all other Texas State students, are eligible to apply for a Texas State-approved study abroad program. However, no money will be awarded to international students for study at Texas State University or in their home country. Students who are on academic or disciplinary probation/suspension are not eligible. All applicants must be Texas Success Initiative compliant and must be in attendance at Texas State University during the semester that precedes their study abroad.
1. Texas State GPA Multiply your Texas State GPA by 10.
Students who apply to study abroad in a location for which the U.S. Department of State has issued a travel advisory level 3 or 4 are not eligible for IEFS.
The IEFS Committee reserves the right to suspend awards to students who have selected programs that are deemed to follow insufficient academic quality and/or health and safety practices. Suspension of awards will be removed once the issues have been resolved to the satisfaction of the university's administration and the IEFS Committee. You are advised to check with Texas State Study Abroad Office to obtain the most current information.
to apply for the IEF Scholarship.
The programs at the "host" school in the foreign country must be approved.
VA cannot pay any fees specific to studying abroad unless the student is required to study abroad as part of their program.
For faculty-led programs, the study abroad program fee is only covered when studying abroad is required as part of a student's degree plan. The tuition for study abroad courses is covered if the class satisfies a degree requirement.
Please reference the GI Bill Fact Sheet for more information on how your VA benefits may be applied to study abroad programs, or refer to the GI Bill FAQ page on the Office of Veterans Affairs webpage.
Extension courses, including study abroad courses, are not covered by the Hazelwood Act unless the course receives tax support, i.e., formula funding. Please refer to the FAQs page of the Office of Veterans Affairs webpage for more information.
Texas State University is required to comply with Section 54.2002 of Chapter 54 of the Texas Education Code, which states that any mandatory or discretionary exemption or waiver from the payment of tuition or other fees applies only to courses for which the university receives tax support, i.e., formula funding. Please refer to the Tuition Waivers & Exemptions page on the Student Business Service webpage for more information.
Consequently, tuition waivers/exemptions do not apply to extension courses, including study abroad. Students are encouraged to contact the agency responsible for administering a particular waiver or exemption in question directly for more information on financial assistance options available.
If you decide to participate in any of the exchange programs offered by Texas State, your tuition and fees will be the same as they would be if you were you studying on campus.
Students who are the first in their families to attend a college or university are eligible to apply for the API First Generation Scholarship, which offers one deserving semester or academic year student a scholarship in the amount of $750.
Students who are studying science, technology, engineering or mathematics are eligible to apply for the API STEM Scholarship, which offers one deserving semester or academic year student a scholarship in the amount of $750.
API strongly encourages eligible students who are interested in studying at John Cabot University to apply for the API/JCU Diversity Scholarship, which provieds one full tuition scholarship per session abroad (Fall, Spring, Summer 1, Summer 2) to an outstanding minority student to encourage diversity at the JCU campus.
Students participating on an API program who have been awarded a Gilman scholarship will be eligible to receive up to $1,000 in matching contributions from API. To receive the API Gilman Matching Scholarship, Gilman winners should indicate their scholarship details on their financial aid information after acceptance to an API study abroad program.
Finally, students are encouraged to apply for API General Scholarships, which range from $250-$1,000 per session. The general scholarship is need and merit-based.
Applications and details regarding these scholarships can be found on the API website. We are so pleased to be able to award over $400,000 in study abroad scholarships annually to assist students in their quest to study abroad.
Each year, AIFS awards more than $800,000 in scholarships, grants, and financial support to deserving students & institutions. Funds are available for fall, spring, and summer terms. For more information click here.
Boren Scholarships and Fellowships provide unique funding opportunities for U.S. undergraduate and graduate students to add an important international and language component to their educations. Boren Scholarships and Fellowships focus on geographic areas, languages, and fields of study that are critical to U.S. interests and underrepresented in study abroad.
Applications and detailed information on the Boren Scholarships and Fellowships are now available on www.borenawards.org.
The Institute of International Education's Freeman-ASIA program provides scholarships for U.S. undergraduate students with demonstrated financial need to study abroad in East or Southeast Asia.
Detailed information is available at http://www.iie.org/programs/freeman-asia.
The Diversity Abroad Network holds a large database of scholarship opportunities for Texas State University students. To look through their database, click here.
The Fund for Education Abroad (FEA) was established to address the need for an independent study abroad scholarship provider. FEA seeks to expand access to study abroad by granting scholarships of up to $10,000. FEA also awards a scholarship specifically for students who attend a university in Texas.
For more information, please visit the Fund for Education Abroad website at http://fundforeducationabroad.org/.
The Gilman Scholarship is sponsored by the U.S. Department of State, Bureau of Educational and Cultural Affairs and is administered by the Institute of International Education. Gilman Scholarships provide awards of up to $5,000 for U.S. undergraduate students who are receiving federal Pell Grant funding at a two-year or four-year college or university to participate in study abroad programs worldwide. Over 2,000 scholarships are usually awarded every year.
For more information about the Gilman Scholarship, application deadlines and timeline, and the application process, please visit the Gilman website at www.gilmanscholarship.org, contact the Gilman Program at (800)852-2141 or e-mail gilman@iie.org.
Phi Kappa Phi offers fifty $1,000 scholarships to students. You do not have to be a PKP member in order to receive this scholarship. For more information please visit PKP's Study Abroad Grants webpage.
In addition to the financial assistance you can pursue at Texas State, there are a variety of foundations and both private and public organizations that provide financial assistance for study abroad.
A Student's Guide to Scholarships, Grants, and Funding Publications in International Education and Other Disciplines, Michigan State University, Rm.209, Office of International Studies and Programs, East Lansing, Michigan (April 1997). Contains 79 pages of annotated bibliographical information on references and websites.
Scholarships, Fellowships and Grants for Programs Abroad (American Collegiate Service, 1989).
Marie O'Sullivan, ed., Financial Resources for International Study, Institute of International Education, New York(1996).
Worldwide College Scholarship Directory, Dan Cassidy.
The Teaching Assistant Program in France offers you the opportunity to work in France for 7 months, teaching English to French students of all ages. Each year, over 1,100 American citizens and permanent residents teach in public schools across all regions of metropolitan France and in the overseas departments of French such as French Guiana, Guadeloupe, Martinique and Réunion.
The Cultural Services of the French Embassy in the United States, in partnership with GoFundMe, with support from NAFSA and the APLU (Association of Public and Land-grant Universities), has launched the third edition of the France on Campus Award under the patronage of film director Wes Anderson, to discover, celebrate and support initiatives that explore France in new and creative ways.
This Award is intended to help student organizations eager to launch or continue a major France-related project on campus by providing a unique package of funding, mentorship and networking. With this support, awardees will be expected to expose new audiences to France and French culture on their campus and beyond. Please note that the call is not limited to student organizations with strong ties to France.


All eyes are on Hurricane Florence and its path toward the Carolinas, but other hurricanes are brewing as well. And the timing couldn't be more apt: Monday was the peak of the Atlantic hurricane season, when storm activity has historically been at its highest.
The National Hurricane Center downgraded Isaac to a tropical storm overnight but said Tuesday that it could be "at or near hurricane levels" on Thursday, when it approaches the Lesser Antilles Islands.
The storm is expected to produce 2 to 4 inches of rain, with near 6 inches possible in isolated areas, forecasters said.
No coastal watches or warnings are in effect Tuesday morning.
Sustained winds on Tuesday morning approached 110 mph, making it a very strong Category 2 storm. No coastal watches or warnings were in effect.
Meantime in the Pacific, Tropical Storm Olivia is still moving toward Hawaii, where tropical storm warnings and watches are in effect, according to the Pacific Hurricane Center.
Gradual weakening is expected as Olivia approaches the main Hawaiian Islands, which it should pass over late Tuesday night into Wednesday. A tropical storm warning means tropical storm conditions are expected somewhere in the area within 36 hours, and a watch within 48 hours.
Olivia's maximum sustained winds are about 65 mph, after the storm weakened from Category 1 strength, forecasters said.


Fat Pig is a drama by Neil LaBute. Helen, a very large librarian, and Tom, a regular guy, have started dating, yet Tom feels the need to keep the details of their relationship secret from his coworkers. His coworkers, Carter and Jeannie, are very judgemental and superficial, yet Tom feels his friends' opinions matter.
Shows performed at the Hard Bargain amphitheater generally do not have a lot of effort put into the set and technical details, and Fat Pig was no different. The basic set of a small desk, shelf, sofa, and tables were functional, allowing the audience to stay focused on the performers. And the performances were fine.
Tessa N. Silvestro as Helen was quite sympathetic, making Helen appear to be a nice, well-rounded, interesting person. Was her joking about her size a self-defense mechanism, or was it her disposition? Watching her describe her large lunch didn't really make us feel uncomfortable about her size, she accepted it, so we accepted it. Watching Tom (Dav Timmerman) squirm in that first conversation was amusing, and quite reminiscent of a first date, making the entire scene seem possible. Timmerman did make Tom into a likeable fellow, especially as he struggled with what to tell his nosy coworkers, Carter (Jivon Lee Jackson) and Jeannie (Brooke L. Howells).
Both coworkers were obnoxious. Jackson was genuine as he continually told Tom how Tom should be living his life. The crazy thing is that Tom seemed to accept Carter's advice. Howells as the scorned woman Jeannie was also effective as she shared her anger with Tom's decision to end their relationship. Carter and Jeannie totally deserved each other.
Timmerman's struggles with how to define Tom's relationship with Helen at times though felt odd. Director Mel Gilpin may have made some odd choices which limited the characters. For example, the scene "Old Territory for the New Couple" felt like it was just another date back at Helen's house watching old movies. But from the text, was something more supposed to have just happened? Was something not presented in that scene? Another example, the final scene, when a decision was reached by Helen and Tom, simply didn't register as a big deal. Hopefully without giving too much away, the final decision reached by the couple just didn't feel "right." It almost felt like it was the right thing to happen for Helen, as she didn't deserve Tom. But the emotions in that scene fell a bit flat.
Here is something that has always bugged me about this play: problems in the script. Does Tom not have any friends who aren't coworkers? Get a life man. Let us see how his family reacts to Helen. Just give us more of development of Tom and why he makes the decision he does. Who really cares what the people I work with think about my personal life? Tom says early on something like "HR wouldn't like me saying that" when he is talking about political correctness of job titles. Then later we discover he was dating a coworker. If the company he works at is large enough to need a full-time expense report paper pusher, and to have an HR department, I'm sure they would also have rules in place about dating those people you work with.
I know I shouldn't hold problems with the script against a theater company. But, all in all, Hard Bargain's Fat Pig was respectable for what they had to work with.
This article can be linked to as: http://washingtondc.showbizradio.com/goto/7085.


To import products from EKM into Tradebox, you first of all need to export a file of products from your EKM site. This option is only available if you are using Tradebox stock control. If you're using Accounts Software stock control in Tradebox, you should import your product records from Sage or Xero instead.
To export the EKM product import file, log into your EKM site and select the Features section at the top. From the list of installed features, choose Import/Export System.
From the two options given, choose to Export to File, and on the next screen choose to Export Products. On the following page, you are able to choose which categories you wish to export products for. We suggest choosing All Categories to give Tradebox a complete record of your EKM products.
Tradebox is configured to accept the file with all fields, so when prompted to select the fields you would like to export, there is no need to make any changes as the fields are all ticked by default. Click next.
On the final page of the export wizard, you are asked to choose a format to export the file in. Tradebox requires this to be a CSV (Comma Separated Values) file. From the drop down box, ensure that Comma Delimited (Default) has been chosen as shown below, and then click on the CSV file button to generate the file.
When complete, a link will appear to allow you to download the file. Save this on to a convenient location on your PC, ready for import into Tradebox.
To import the file, go to Products in Tradebox, and click on the Actions menu. Select EKM as the Source and then browse to the file, and click OK.


What do you get with our IVR Survey Software?
You can define multiple questions and there is no restriction on the number of participants.
Accessibility over any phone is systems' biggest strength. Feedback from hundreds of participants can be handled by the cloud-based system in minutes as opposed to days in a conventional survey.
The system enables you to take feedback via IVR, Missed Call and Incoming SMS.Also, as there is no human involvement, the app ensures honest and accurate feedback.
Since the feedbacks are collected online, participants from different location can be involved.


Established in honor of the retirement of Dr. Robert A. Chernak as the Senior Vice President and Senior Vice Provost for Student and Academic Support Services, this fund supports the diverse efforts and interests of individual students and groups of students to pursue and create opportunities that come their way, much as Dr. Chernak did over the course of his 24-year tenure at the university.
Read more about #onlyatGW experiences supported by the Chernak Opportunity Fund or make a donation.
Student organizations: Chernak Opportunity Fund awards are now available up to $300 per program or project, with each student organization eligible to receive one award per calendar year. Learn more about the Chernak Opportunity Fund and apply here.


text:
Q: how to shift the key focus between two clutter_actors? Hi i have two clutter_actors . when i shift the focus from actor_1 to actor_2 for the first time it works. but later it does not shift back. I use the following statements.
clutter_stage_set_key_focus (CLUTTER_STAGE(stage), actor_2);
g_signal_connect (actor_1, "key-press-event", G_CALLBACK (button_key_press), NULL);
clutter_actor_set_reactive (actor_2, TRUE);

Am I missing anything ?

A: I solved it.
It was very easy. Its the same code i have used which i have given in the question.
Actually i was giving the key focus to actor_2 when i wanted to shift the focus from actor_2 to actor_1 . It was a logical error from my side.

redpajama_set_name: RedPajamaStackExchange


Sweden is a cold country judging by its weather, but seeing this cozy and welcoming Scandinavian apartment makes me believe that's not so important anymore. The abundance of white, the large windows and the high ceiling give the impression of an even bigger space. How great it would feel to return to such a beautiful home at the end of a work day and maybe relax reading a book on the window sill, surrounded by comfty pillows!
To revive the atmosphere, small accents of color do their job. The bedroom is a loft, so this apartment is great for those of you who have lots of friends and for those who like to socialize, as it offers so much space to play with. Many details remain from the last century, enriching the interior with history. And to complete the perfect description, the apartment has an open space where, hopefully, you can enjoy some fresh air and beautiful stars at night.


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Target/Movies, Music & Books/Books/All Book Genres/Fiction & Literature
The Code of the Woosters - by P G Wodehouse (Paperback)
Genre: Fiction + Literature Genres
Sub-Genre: Humorous
Publisher: W. W. Norton & Company
Book theme: General
Author: P G Wodehouse
Street Date: July 5, 2011
Follow the adventures of Bertie Wooster and his gentleman's gentleman, Jeeves, in this stunning new edition of one of the greatest comic novels in the English language. When Aunt Dahlia demands that Bertie Wooster help her dupe an antique dealer into selling her an 18th-century cow-creamer. Dahlia trumps Bertie's objections by threatening to sever his standing invitation to her house for lunch, an unthinkable prospect given Bertie's devotion to the cooking of her chef, Anatole. A web of complications grows as Bertie's pal Gussie Fink-Nottle asks for counseling in the matter of his impending marriage to Madeline Bassett. It seems Madeline isn't his only interest; Gussie also wants to study the effects of a full moon on the love life of newts. Added to the cast of eccentrics are Roderick Spode, leader of a fascist organization called the Saviors of Britain, who also wants that cow-creamer, and an unusual man of the cloth known as Rev. H. P. "Stinker" Pinker. As usual, butler Jeeves becomes a focal point for all the plots and ploys of these characters, and in the end only his cleverness can rescue Bertie from being arrested, lynched, and engaged by mistake!
Trending Fiction & Literature
Moral Compass - by Danielle Steel (Hardcover)
Where the Crawdads Sing - by Delia Owens (Hardcover)
The Girl He Used to Know - by Tracey Garvis Graves (Paperback)
Dear Edward - by Ann Napolitano (Hardcover)
Tattooist of Auschwitz - by Heather Morris (Paperback)
Lost - by James Patterson & James O Born (Hardcover)

redpajama_set_name: RedPajamaCommonCrawl


text:
Nothing Cuts Like…
Nothing Cuts Like a 4K Chainsaw
Horror Features Slasher
Doctor Caligari
Ever since 1974, the notorious buzz of Leatherface's chainsaw still rips it way through the peoples consciousness.
Even today and with the re-release of
Tobe Hooper's superb original hitting selected cinema screens restored in fantastic 4K resolution, I thought I would pull the chord on how The Texas Chain Saw Massacre has hacked its way through the ages to become one of cinemas most sadistic horror movie ever made.
The Texas Chain Saw Massacre was made on a budget of around $80,000. This small budget forced the entire cast and crew into a long laborious shoot which went on for weeks on end under the extreme Texan heat.
These tiresome conditions along with the very unique props and special effects (most of the fake blood used was real animal blood from the local abbattoir) conjured up truly traumatising performances that has helped send audiences into a frenzy. Even now, the new sound mix accompanying the 4K restoration makes the screams from the actors a more horrifying experience than the chainsaw buzz itself.
Upon the films release back in '74 it became the 12th highest grossing film of the year, but interests for it grew and grew. That interest quickly turned into controversy and the film was ended up being banned all over the place.
It wasn't until 1999 that the BBFC agreed to grant the film an 18 certificate. One year later Channel 4 snapped up the rights to broadcast it which then became headline news: http://news.bbc.co.uk/1/hi/entertainment/974619.stm.
Now, during the 2014 Cannes Film Festival, it was paid a special tribute by having a beautifully sharp restoration made with an introduction to by Drive director Nicolas Winding Refn. Refn went on to say how this film inspired him in wanting to become a director after seeing it when he was 14, he then goes on to explain: "The curse of the film is that it's a masterpiece… When you make a film that goes beyond filmmaking, it's no longer just a movie." (Full video here: http://www.youtube.com/watch?v=eiaB_Eragug.
Receiving this kind of ovation now, after all the backlash it developed just goes to show the never ending curiosity and impact its had through the years, always 'one-up'ing itself into the public conscious and back in to cinema screens.
Of course, with this much attention, the success of the film became massive and its main antagonist, Leatherface has now gained a reputation for being a key player in the horror genre.
Actor Gunnar Hansen, the original Leatherface, sought inspiration for the character from observing the mannerisms of disabled children. Unlike the mysterious workings of Jason Voorhes or the supernatural spin to Freddy Krueger, Leatherface acted out with violence in self defence when he felt threaten.
Despite his cannibalistic family pulling the strings, Leatherface has become the iconic member. He's become so popular that he's even been made in to an awesome action figure and he's even had the lunch box treatment.
Atari even saw how popular he had become and decided to produce a video game adaptation of the Texas Chain Saw Massacre. In the game, players could become Leatherface as he attempts to mow down trespassers on his farm whilst avoiding scattered skulls.
So, what a fitting way to celebrate 40 years of chainsaw savagery than releasing it in glorious 4K resolution with Hooper himself working on the restoration process.
Although it's crisp new image is sharp and sleek, it still retains a heavy grain and a gritty feel that still makes Chainsaw a thrilling and face-paling experience.
Taking a whopping 5 months of time to complete, engineer Boris Seagraves spent his weeks going through the original 16mm print and removed dirt, scratches, rips in the image, chemical stains and glue splices to then digitally scan and stabiles the images; "When doing a digital scan of a conformed 16mm print with a splice at every cut, it can be tough to achieve the high standards we all aspire to in the era of digital cinema. What might have passed as acceptable in the 70's looks jarring now. So we worked hard to smooth out the tremors that almost inevitably occur when scanning this type of film element." Said Seagraves. (Full interview here: http://bloody-disgusting.com/news/3282090/full-details-4k-stills-for-restored-the-texas-chain-saw-massacre/).
If you're a horror fan, you've bound to have seen this countless times but to relive the fear again, back in the cinema, I can not advocate enough.
The new 40th Anniversary restoration (two disc limited edition steelbook) of The Texas Chainsaw Massacre is available to buy on Blu Ray right now:
The Texas Chain Saw Massacre: 40th Anniversary Restoration – 2 Disc Limited Edition Steelbook [Blu-ray]
Tags: Leatherface Texas Chain Saw The Texas Chainsaw Massacre
On a cold winters morning the doorbell of Love Horror's haunted offices rang and we opened the security gates to find that we had received delivery of a very old, very large German cabinet... More
Hatchet 3 and so much more coming to…
Open Grave (2013) Review
Horror Film Reviews Psycho
The Furies (2019) Review
Little Shops of Horror – Minifigs Me
LEATHERFACE horror movie DVD bundle


The word is out on Fun Fun Fun Fest's 2013 music lineup, which was leaked Tuesday night at an East Austin screening of Vannin' hosted by the festival. Previous lineup leaks revealed the likes of Ice-T and The Walkmen, but the latest announcement sets the full tone for the 8th annual event.
"Pound for pound, this is probably our most powerful lineup in our eight-year history," said James Moody, co-owner of Fun Fun Fun Fest in a press release. "We are staying true to our roots, while still pushing the limit on new ideas, discoveries and experiences for our fans," he continued of the lineup that includes festival veterans and up-and-comers.
Colorful headliners represent the festival's "anything goes" identity, one that has created an immersive, multi-genre music experience respected nationwide. With the likes of Snoop Dog, Slayer, MGMT, M.I.A., Jurassic 5, Ice-T and Television on the bill, Fun Fun Fun Fest caters to rock, metal and rap fans, and provides plenty of discovery opportunities for festival-goers outside of strict genre confinements.
The Yellow Stage (for comedy and oddity shows) will also return this year, along with the Skate/Ride feature. Those lineups will be announced in August at Fun Fun Fun Fest's third annual Aqua Olympics.
Here's the lineup for Fun Fun Fun Fest 2013, which takes place November 8 through 10.
Tickets to the festival are on sale July 10 at 10 a.m.


text:
Data / Artificial Intelligence
Blockchain / Crypto / FinTech
Webshops / Platforms / E-Commerce
Hardware / Industrial Products
LEXR is specialized in delivering customer-focused legal services for businesses.
+41 44 544 13 30 Our operating hours are 9:00-17:00 Mon-Fri
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First proposal of a coexistence agreement to prevent a reduction of the scope of protection of your trademark.
I am searching for a name for my company/product/service. What do I need to know?
Of course, branding is mainly about marketing. However, the legal aspects should not be underestimated: Perform proper trademark research to avoid having to rebrand later on because you are infringing on someone's rights. If you plan to register your brand name as a trademark, make sure that your brand is not excluded from registration, e.g. because it's misleading or descriptive for the services you're offering. And, depending on your industry: How strong is your brand name as a trademark? To fight off copycats efficiently, the trademark should be as distinctive as possible.
Do I really need a trademark?
No. A trademark is not needed to offer goods or services. If you prove that you used the trademark for certain things in the past, no one can prohibit you the use it to the same extent by registering "your" trademark. However, registration is still useful in many cases.
When do I need a trademark?
This highly depends on your intended use. As a rule of thumb: The stronger your brand, the more useful the trademark. The more you rely on the quality of your goods/services and not on its uniqueness, the more useful the trademark. If you're in the B2C-business and have a large customer range, it's more useful than if you have a few specialized business clients that know you personally. Also, take into account which markets your present. If you are not sure, ask an expert.
I got my trademark registered. What now?
The trademark gives you the freedom to use it for the goods and services you registered for. But that's just the beginning: To prevent the weakening of your trademark, you should fight off new registrations or unregistered use of similar marks. The easiest way to do this is by monitoring new registrations and informing any noticed infringers about your rights. Also, you can assess whether you can capitalize your trademark, e.g. by licensing it.
I received a "Cease & Desist"-letter, stating that I infringe someone's trademark. What should I do?
Contact a legal expert. Often, such letters are baseless or even a scam, but sometimes the other party is correct and you should try to negotiate an amicable solution.
Your legal experts
Thomas focuses on intellectual property protection and tech contract law. He advises clients on strategies for the protection of their trademarks, data, inventions, and know-how as well as on various legal matters concerning technology.
Before starting at LEXR, Thomas worked in leading law firms in Switzerland and Denmark where he gained extensive experience in his fields of practice and broad knowledge of Swiss and European law.
Christian Meisser
Christian has advised tech companies and regulated industries on data privacy since 2013, working at international law firms in Zurich and London. Since then, he advised countless data-driven businesses on how to use data as a business asset and build a compliant data privacy governance.
Besides building deep privacy expertise working with customers in Switzerland and Europe, Christian published articles and regularly holds workshops and trainings on data protection for businesses.
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Discover new ways to treat and manage your patients with cardiovascular conditions with the AAFP's Care of Cardiovascular Conditions Self-Study Package. This resource tool allows you to both hone your clinical skills and review key issues that include pulmonary hypertension, dyslipidemia, sleep apnea and heart disease, valvular heart disease, pediatric hypertension, and more—on a schedule that works best for you—in a variety of formats.
This dynamic, 24-session video self-study was recorded from the AAFP Care of Cardiovascular Conditions live course. Use it to improve patient satisfaction while learning the latest required updates, focusing on the treatment of cardiovascular disease, and gain knowledge you can immediately apply in practice.
This self-study package is approved for up to 25 AAFP Prescribed credits. CME credit approved through April 2, 2021.
Note: Access to online content ends April 2, 2021.
This Enduring Material activity, Care of Cardiovascular Conditions - 1st Edition, has been reviewed and is acceptable for up to 25 Prescribed credits by the American Academy of Family Physicians. Term of approval begins April 3, 2018. Term of approval is for three years from this date. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The American Academy of Family Physicians designates this Enduring Material activity for a maximum of 25 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.


It's a little bit of work but it doesn't seem too hard.
Unless you have a specific desire to use the PEB, the simplest method is the CF7 - this great little device plugs into your console, provides 32K of CPU RAM, a CF card reader that emulates all three disk drives, and a parallel port.
You just copy your PC99 or TIDisk images onto the CF card on the PC, plug the card into the CF7 and away you go.
Yeah that would be best, but you need to get a hold of one first. I need to watch ebay when they show up.
I will once I get my mother in-laws old laptop (we got her a new one for Christmas). My current computer doesn't have any, but the laptop is over four years old so it must.
computer "talk" to a Dell?
I had it done easy with a serial cable from the TI's port (in my Peripheral Expansion Box) to the old laptop. Correct terminal emulator programs running on both ends and saving to the laptop's 3.5; then from the 3.5 on my old PC to the folder on the hard drive the the "Classic99" emulator was using. It was easy and very cool to "back up" some 1980's games that would have been lost forever.
http://retrofloppy.com/products.html scroll down to the USB adapter, you can find something like that (for allot less on ebay) to get what you want done without needing a older computer with a RS-232 port.
OMG i got tricked into posting in a zombie topic.
Edited by madmax2069, Mon Jun 7, 2010 11:42 PM.


15.12.030 Permit – When Required.
It is unlawful to construct, extend, relay, repair, or make connection to any private sewer or sewer main without obtaining a permit pursuant to the provisions of Snohomish Municipal Code from the City Engineer. The City Engineer may issue such permit to the owner or occupant of any property to construct, extend, relay, repair, or make connection to any private sewer inside the property lines. Should the owner or occupant employ a licensed contractor to do the work, such contractor shall take the permit in his or her own name, and the owner, occupant, or any other person shall lay no pipe under the authority of the contractor's permit. Any work outside the property line and inside the City rights of way shall require a licensed contractor.


Working at WNC Insurance Services means being part of a team of dynamic professionals with a passion for service, innovation and collaboration. Being at WNC means that no challenge is too big or too difficult. We believe we have the experience and expertise to offer the best solution for our clients, and if need be, the resources and determination to develop it.
These are the same attributes that we seek in future members of our team. We need individuals with a strong desire to learn and to apply knowledge and skills to find the best answers. We want professionals with the entrepreneurial drive to stand out and aim higher, the willingness to question traditional answers, and if opportunity dictates, the confidence to sidestep the path of least resistance.
When you join our team, you will learn that integrity is our most valuable offering. We deliver results that make our clients' work easier. We fulfill their commitments as if they were our own. This is the central theme of our manifesto. It is also what makes working at WNC a promising opportunity to learn, create, serve and succeed.
At WNC our success is ultimately built on the talents and skills of our people, drawing on their combined expertise, knowledge and willingness to collaborate to provide you with the best products, services and support every day.
Each team is led by industry veterans with deep product knowledge and a passion for building the business based on client success. We do our best to offer our employees a rewarding career that helps them grow, develop and play to their strengths.
Steve Griffith joined WNC in 2018 as Chief Human Resources Officer. In his role, he is responsible for driving strategic talent and culture initiatives across the organization, including leadership and employee development, succession planning, talent assessment and performance management, employee engagement, recruitment, compensation, and employee relations.
Steve has more than 30 years of experience in the field of human resources, talent management and executive coaching, serving in a variety of roles of increasing scope and responsibility in multiple industries. In his most recent position, he was Vice President of Global Talent Development for Alight Solutions, where he was responsible for leadership and management development strategy, an organization learning platform, performance management, employee engagement, diversity and inclusion, and culture initiatives. Prior to that position, he served as Vice President, Executive Coach for Robertson Lowstuter, a senior-level executive development, coaching and career transition/outplacement services firm.
Steve holds a Master of Arts degree in industrial-organizational (I/O) psychology and organizational development from the University of West Florida and a Bachelor of Science degree in psychology from the University of Wisconsin – La Crosse. He also holds a certificate in leadership coaching from Georgetown University.


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New Books in African Studies
Travel Marshall Poe History Society University Press
By Marshall Poe. Discovered by Player FM and our community — copyright is owned by the publisher, not Player FM, and audio is streamed directly from their servers. Hit the Subscribe button to track updates in Player FM, or paste the feed URL into other podcast apps.
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Gregg Mitman, "Empire of Rubber: Firestone's Scramble for Land and Power in Liberia" (New Press, 2021)
In the early 1920s, Americans owned 80 percent of the world's automobiles and consumed 75 percent of the world's rubber. But only one percent of the world's rubber grew under the U.S. flag, creating a bottleneck that hampered the nation's explosive economic expansion. To solve its conundrum, the Firestone Tire and Rubber Company turned to a tiny West African nation, Liberia, founded in 1847 as a free Black republic.
Empire of Rubber: Firestone's Scramble for Land and Power in Liberia (New Press, 2021) tells a sweeping story of capitalism, racial exploitation, and environmental devastation, as Firestone transformed Liberia into America's rubber empire.
Historian and filmmaker Gregg Mitman scoured remote archives to unearth a history of promises unfulfilled for the vast numbers of Liberians who toiled on rubber plantations built on taken land. Mitman reveals a history of racial segregation and medical experimentation that reflected Jim Crow America—on African soil. As Firestone reaped fortunes, wealth and power concentrated in the hands of a few elites, fostering widespread inequalities that fed unrest, rebellions and, eventually, civil war.
A riveting narrative of ecology and disease, of commerce and science, and of racial politics and political maneuvering, Empire of Rubber uncovers the hidden story of a corporate empire whose tentacles reach into the present.
Gregg Mitman is the Vilas Research and William Coleman Professor of History, Medical History, and Environmental Studies at the University of Wisconsin–Madison. An award-winning author and filmmaker, his recent films and books include The Land Beneath Our Feet and Breathing Space: How Allergies Shape Our Lives and Landscapes. He lives near Madison, Wisconsin. Website.
Brian Hamilton is Chair of the Department of History and Social Science at Deerfield Academy. Twitter. Website
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Kuwait Energy plans London listing
The firm said it expects to raise around $150m from the IPO
Oil and gas exploration firm Kuwait Energy is planning to become the first company from the Gulf nation to list on the London Stock Exchange.
In a bourse statement, the firm said it expects to raise around $150m from the IPO, which is expected to start trading in June.
Bloomberg reports that the listing comes as Kuwait introduces regulatory changes to attract more foreign investors to its equity market.
Kuwait Energy said it has 10 exploration, development and production assets in Egypt, Iraq, Oman and Yemen. Of these it operates seven, according to the filing.
The firm produced 24,432 barrels of oil a day last year from 24,988 in 2015, it said.
Numis Corp and Bank of America are joint global coordinators for the listing and EFG Hermes is a bookrunner on the IPO, according to Kuwait Energy.
Staff Writer May 3, 2017


Come and visit Cabane Chez Dany in Quebec; this authentic Canadian maple syrup sugar shack is a perfect place to relax and take in your own little slice of Canadiana. Enjoy the quaint country charm and the beautiful forest scenery while being served by the best of French Canadian hospitality. Tours are guided and show you the area as well as the processes behind manufacturing our sweet treats. Enjoy your sightseeing tour and taste our maple taffy poured over snow.


The following article is the last in an eight-part series produced by The Beacon on domestic violence. Called the Domestic Violence Awareness Project, the series aims to educate our readers while offering information – and hope – to those needing help.
The "golden years" are often thought of as a time for those in retirement to kick back, relax and enjoy life after many years of working and raising families. But for some, those years can be lonely and isolating – leaving seniors vulnerable to abuse.
According to the National Center on Elder Abuse, it is hard to know for certain how many elderly are suffering from abuse. Cases of elder abuse go widely unnoticed and unreported.
The NCEA website cites one study that estimated only one in 14 cases of elder abuse comes to light. For those that are brought to the attention of authorities, about 90 percent of the abusers are family members.
"Calls made about elder abuse directly to the police department are infrequent," said Edmonds Police Department Detective Stacie Trykar said.
Most of the calls she receives are reported by Adult Protective Services. APS is mandated – by law – to report cases of abuse, but Trykar said when a report comes in, it has typically been made by a healthcare worker, in-home caregiver or family member – not the victim.
'We receive calls from family, friends, caregivers, neighbors, Senior Services of Snohomish County and other people that may discover the abuse," said Karla Potter of Domestic Violence Services of Snohomish County said.
She said often the abuse has gone on for decades, and the victim has hidden it from friends and the community.
In the case of physical abuse, Potter said abusers don't become nicer as they get older;, instead, it only gets worse.
People are living longer and dealing with mental and physical health challenges as they age, she said.
In some instances, the abuser will withhold medical help, medication, food and money, and will isolate the victim from friends and family.
She said many elders do not want to go to the DVS shelter; they want to retain their freedom and remain in their homes.
"I am currently working with a woman who is isolated in an outlying area," Potter said. "Her abuser was just released from prison, and brings his drugs and friends into the home.
"She is disabled, and cannot figure out how to get out. He takes her money, and she has three cats she can't leave behind.
Potter has been in touch with the woman since Jan. 19, and said this is not an isolated case. She calls or emails other victims weekly to check in and make sure they are safe.
Lori Stevens, of Senior Services of Snohomish County, said isolation does factor into abuse of seniors.
"There are definitely signs," she said, "but they are harder to detect.
The aging population is growing, and according to the 2010 census, from the U.S. Census Bureau estimates about 40.3 million, or 13 percent, of the total U.S population is over 65 years of age, and will make up 20 percent of the population by 2050.
Locally, the elderly are a much higher percentage of the population. The Snohomish Health District estimates that people over 50 years old make up one-third of the county's population, and one-quarter of people over 65 years of age lived alone in 2010.
While they may be living alone, many elderly have either family members or in-home caregivers to assist with daily living and financial matters.
In addition to physical abuse, Trykar said, elders are often the target of financial abuse and exploitation.
Many times an elderly person will give a family member or caregiver access to his or their bank accounts, she said, only to find out that person has "drained" his or her account of funds.
Financial institutions play a big part in helping to discover this type of abuse, she said.
In one case, she got a call from a bank regarding suspicious activity with a long-term customer's account. His account had been whittled down to almost nothing within a week by his caregiver.
Trykar explained what was happening to the victim, but he was unwilling to press charges.
Trykar said the victim was clearly being exploited, but he wanted to remain in his home.
Other types of scams include fake phones calls by someone pretending to be from the IRS or other governmental institutions, fake sweepstakes, or even someone pretending to be a family member in need of money for an emergency.
She said victims of domestic abuse may not report it for several reasons: the victim does not want to lose their freedom by being put in a nursing home; the victim may have dementia or other mental health problems, and may not be able to articulate what is happening, and might be fearful of repercussions; and embarrassment.
On May 13, Senior Services will host a full- day Vulnerable Adult Abuse Conference in Everett. For more information, visit www.SSSC.org.
"We will have speakers from The Everett Police Department, Adult Protective Services, Northwest Justice Project, Victim Support Agencies and others on abuse topics that affect senior citizens," Stevens said.
How can the elderly protect themselves from domestic abuse?
Stay involved with the community as much as possible – do not become isolated.
Be on guard for scammers who may call you or mail you something, claiming they are from the IRS, Social Security, Medicare, your bank, etc.
Plan ahead for when you may not be as capable or cognitively aware to make decisions as you become older. Have a reliable, responsible and trustworthy power of attorney in place for that time.
If you or someone you know is involved in a domestic violence situation, call 911 and seek help first. The following safety plan and checklist can help keep you safe and help you prepare to leave.
These are the important items you should have with you when you decide to leave. Some of them can be kept somewhere other than at home.


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"Man of Steel 2: Henry Cavill Himself Confirms His Return
Many projects were announced last week
With "Black Adam" the newest movie from the DCEU is currently running in theaters and those who have already seen the movie might have been pleased about the one or other surprise. One important person in the future of the DC film universe will at least be Henry Cavill, as he personally confirmed via Instagram this week. More than five years after his last appearance in "Justice League", the 39-year-old is now officially coming back to his role as Superman, after this had been prevented by those responsible in the years before.
The plans for a new "Superman" movie are consistent with the statements made by Dwayne Johnson during the promotional phase of "Black Adam". After all, Johnson often talked about a potential clash between his character and Superman and allegedly also advocated for Cavill's return behind the scenes. At the moment, it is not known what exactly the upcoming "Man of Steel 2" with Henry Cavill will look like, but we do hope for more news soon that go beyond the mere announcement.
Man of Steel 2


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Science and Technology Forum
Gambia Six Hours Without Internet New Topic Reply to Topic
The Gambia Six Hours Without Internet, The Second Outage In Less Than A Month
By Frederic Tendeng
The Chronicle: Feb 2, 2021
https://www.chronicle.gm/the-gambia-six-hours-without-internet-the-second-outage-in-less-than-a-month/
GAMTEL's photographic description of the January 2021 Internet shutdown
The Gambia has this Tuesday suffered another Internet shutdown for about six hours, with all operators being severed of any bandwidth data transmission while customers struggled to understand what happened.
It was only hours after the Internet outage hit the country that some service providers began sending scanty text messages to customers to fault a cable cut and crave for the subscribers indulgence.
The Gambia Telecommunications Company (GAMTEL), the main Internet gateway and service provider to the country only came out to explain what happened seven hours after the breakdown, when the wide bandwidth data transmission was finally restored. �In the past few hours we have experienced a links failures on ACE and backup link impacting general traffic which was beyond our control. Our engineers worked tirelessly with our international partner for immediate solution. While we continue to monitor the connectivity, we thank all our customers for patience and apologies for any inconvenience this have caused� GAMTEL said in a social media post.
It�s the second time The Gambia is off Internet connection as we may recall that in early January, an ACE cable shunt fault was blamed to have caused a shutdown of the Internet ACE traffic for over a week. As The Gambia has an unfit for purpose Internet backup infrastructure, GAMTEL announced that it has rerouted all its Internet traffic via its Senegal�s hosted SONATEL link.
"GAMTEL announced that it has rerouted all its Internet traffic via its Senegal�s hosted SONATEL link."
Gambians should welcome this neighbourle assistance from Senegal whilst repairs take place with ACE infrusture which operates in quite a hostile environment,In case Dear Reader you are baffled by what ACE is I have found a Gambian link that will start you on your guest for information on ACE, if you want to know more open the link below:
https://www.pura.gm/portfolios/photography-project/
The Gambia is one of the African Countries which remains to date without connectivity to submarine cable and rely exclusively on satellite communications and fibre optic connection through neighboring countries for international connectivity. The result has been an unreliable service and high prices for international calls and internet connection. This, coupled with a deteriorating national backbone infrastructure has created a difficult environment for expanding availability. The lack of access to low price and high quality telecommunication services is one of the factors that limits The Gambia�s potential to create jobs, expand production of goods and services and trade competitively with the rest of the world.
The Government of The Gambia (GOTG) in its quest to achieve the Millennium Development Goals (MDGs) and its blue print �Vision 2020� objectives saw the need for improving The Gambia�s international connectivity, as well as for greater regional economic and communication infrastructure integration. For this reason, the GOTG has decided, along with many other West African countries, to become a member of the Africa Coast to Europe (ACE) fiber-cable project.
A Special Purpose Vehicle (SPV) �The Gambia Submarine Cable Co. Ltd� has been established between the private Global System for Mobile Communications (GSM) operators, the Internet Service Providers (ISP), the GOTG and the Gambia Telecommunications Company (GAMTEL/GAMCEL) to participate in the ACE consortium and secure access to capacity.
The Government of The Gambia through GAMTEL signed the ACE �Construction and Maintenance Agreement� (C&MA;) on 5th June 2010 and has accordingly become a member of the ACE consortium and will be part of the new fiber-cable system. This support forms part of the West Africa Regional Communications Infrastructure Program (WARCIP)Gambia Project prepared by the GOTG with financial support from the World Bank through an International Development Association (IDA) grant of US$35 million.
On 12th September 2011, the ACE fibre cable from France landed in The Gambia the beach by the Lemon Creek Hotel in Bijilo at about 13:10 hrs. The official landing was witnessed by key stakeholders from the telecoms industry in The Gambia as well as by PURA.
OPPS.....
https://foroyaa.net/internet-disrupted-in-gba-after-personnel-working-for-nawecs-indian-project-inadvertently-cut-internet-cable-at-farato/
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Mustapha Jallow on February 2, 2021.
The Public Relations Officer of the National Water and Electricity Company (NAWEC), Pierre Silva has confirmed to Foroyaa that their personnel working for their Indian Project at Farato cut an internet cable which caused internet black-out on Tuesday afternoon 2nd February, 2021.
PRO Silva said the officials of the aforesaid project were digging to lay pipes and �they ran into an internet cable and cut it.�
Silva�s confirmation came after Foroyaa informed him about a credible source who informed this medium that the blackout was as a result of �fiber cut on the internet cable at Farato.�
The source, who pleaded for anonymity, told Foroyaa that NAWEC officers cut an internet backup cable at Farato while dipping and/or fixing their water pipes.
The source added that a technical team was immediately deployed on the ground to ensure they repair the cable and restore the internet back.
�But I think the power has been restored,� PRO Silva said.
According to Silva, he made calls to confirm our insider�s information.
He said first called the IT Director of NAWEC, but his number was engaged, and so he had to call their managing director (NAWEC), who confirmed to him that it is true that personnel working for their Indian Project were digging at Farato and ran into an internet cable and then cut it in the process and he (MD) was contacted by Qcell.
Meanwhile, several hours of internet black-out has disrupted many businesses, especially those within the Kanifing Municipality.
Many work places, which heavily rely on internet to carry out their businesses, suffered the most setbacks. Customer service operators and consumers were among those hard hit.
Also, many people couldn�t buy cash power as a result of this hitch.
�There is an internet problem throughout the country so they cannot sell cash power when there is no internet,� NAWEC PRO, Pierre Silva told Foroyaa.
It was observed that commercial banks in the Kanifing Municipality and their customers were hit too. Sight of frustrations could be seen in the faces of most customers, especially those who rely on daily withdrawal.
Ida Cham, a customer found sitting outside Trust Bank Limited at Westfield, described the internet problem as �frustrating�� because she came for withdrawal, but she was told that there was no internet.
�I came to withdraw some money for tomorrow�s �fish money� but I felt disappointed after I was told that there was no internet. And I have run out of cash for tomorrow,� she narrated.
A lady who doesn�t want her name to be mentioned, said the bank she went was only rendering services to those who came for deposits. Those who wish to withdraw could not be accorded the opportunity because there was no internet.
No internet connection in Gambia today either!!!
https://standard.gm/it-association-of-gambia-dismayed-at-internet-outages0/
The president of the IT Association of The Gambia, Ms Beran Dondeh-Gillen, has released a statement on behalf of her association expressing its dismay over the recent frequent Internet outages in the country.
The release issued yesterday stated: �The IT Association of The Gambia (ITAG) notes with disappointment yet again the Internet outage that occurred this Tuesday 9th February around 7am. In a space of five weeks, The Gambia has seen four Internet outages ranging from four hours to over 10 hours. ITAG as the umbrella body of all ICT companies in The Gambia would like to highlight the effect this downtime has had on not only its membership but the public and private sector.
�The economic effect of these outages when calculated are in the millions across the tech industry alone. Where more and more businesses are working online and struggling with the effects of the pandemic, Internet outages have compounded the losses businesses have incurred significantly, causing some to close shop temporarily.
Beran Dondeh-Gillen, the president of ITAG said: �The Internet is the heart of every company, in these pandemic times were systems work more online than offline. These outages have not only an economic and financial impact but also a social impact that affects our lives and livelihood. It is therefore pertinent that the right policies are put in place and implemented to ensure redundancy in our access to critical resources such as the Internet.�


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Suffocating tumours could lead to new cancer drugs
Scientists have discovered a new molecule that prevents cancer cells from responding and surviving when starved of oxygen and which could be developed into new treatments for the disease, according to new research published in the Journal of the American Chemical Society* today (Friday).
Cancer Research UK scientists at the University of Southampton found that this molecule targets the master switch – HIF-1 – that cancer cells use to adapt to low oxygen levels, a common feature in the disease.
The researchers uncovered a way to stop cancer cells using this switch through an approach called 'synthetic biology'. By testing 3.2 million potential compounds, made by specially engineered bacteria, they were able to find a molecule that stopped HIF-1 from working.
All cells need a blood supply to provide them with the oxygen and nutrients they require to survive. Cancer tumours grow rapidly and as the tumour gets bigger it outstrips the supply of oxygen and nutrients that the surrounding blood vessels can deliver.
But, to cope with this low-oxygen environment, HIF-1 acts as a master switch that turns on hundreds of genes, allowing cancer cells to survive. HIF-1 triggers the formation of new blood vessels around tumours, causing more oxygen and nutrients to be delivered to the starving tumour, which in turn allows it to keep growing.
Dr Ali Tavassoli, a Cancer Research UK scientist whose team discovered and developed the compound at the University of Southampton, said: "We've found a way to target the steps that cancer cells take to survive and we hope that our research will one day lead to effective drugs that can stop cancers adapting to a low oxygen environment, stopping their growth. The next step is to further develop this molecule to create an effective treatment."
Dr Julie Sharp, senior science information manager at Cancer Research UK, said: "Finding ways to disrupt the tools that cancer cells use to adapt and grow when starved of oxygen has been a hot topic in cancer research, but finding drugs that do this effectively has proved elusive.
"For the first time our scientists have found a way to block a master switch controlling cells response to low levels of oxygen – an important step towards creating drugs that could halt cancer in its tracks."
Read a blog post about Dr Tavassoli's research here.
1. *Miranda, E et al. A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signalling in cancer cells Journal of the American Chemical Society (2013)
http://dx.doi.org/10.1021/ja402993u
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Le soma est, dans le roman dystopique Le Meilleur des Mondes d'Aldous Huxley, une drogue artificielle de synthèse présentée au peuple comme étant un simple médicament.

Les citoyens sont tous incités à utiliser ce produit qui peut, à forte dose, plonger celui qui en prend dans un sommeil paradisiaque.

Il se consomme sous forme de comprimés, distribués au travail en fin de journée. Cette substance est supposément le secret de la cohésion de cette société : grâce à elle, chaque élément de la société serait heureux et ne revendiquerait rien.

Elle est présentée comme étant dénuée d'effet secondaire indésirable.
Son effet et sa prise à répétition par les divers personnages du roman est un ressort essentiel au maintien de l'univers créé par Huxley. Il introduit une dimension d'habitude sociale liée à l'éducation, consommer cette drogue est un recours indispensable aux utilisateurs pour lutter contre les maux de la vie en société, elle a pour effet de remplacer la cigarette ou l'alcool de notre monde réel.

Les individus de toutes les castes se satisfont de leur statut par le double usage du conditionnement hypnopédique et du soma.

Le thème de l'altération de la perception et de la drogue comme moyen de fermeture ou d'éveil pour l'esprit sera plus tard important dans la vie et l'oeuvre de l'auteur ; le soma n'est pas sans rappeler la mescaline, expérimentée par Huxley, expérience qui sera à l'origine de l'essai Les Portes de la perception (1954).

Étrangement au cours des années 1950, un produit hypnotique sera commercialisé sous le nom de Soma : le carisoprodol, un analogue de la méprobamate. La classe des carbamates dont il fait partie se voit progressivement retirée des marchés du fait d'un potentiel d'abus et de surdosage excessif.

Notes et références

Drogue de fiction

redpajama_set_name: RedPajamaWikipedia


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Lawmaker seeks to up Alaska's legal age of marriage to 18 – The Seattle Times
KETCHIKAN, Alaska (AP) — An Alaska lawmaker is seeking to change the state law that allows a person as young as 14 to marry.
State Sen. Berta Gardner is planning to introduce legislation to increase the legal age of marriage to 18 in Alaska, the Ketchikan Daily News reported.
The Democratic senator's legislation would also allow emancipated minors above the age of 16 to marry.
Under current state law, a person between the age of 14 and 18 can marry with permission from a superior court judge. After a hearing with the parents and the minor, the judge may grant permission if the "marriage is in the best interest of the minor," according to the state law.
"I was shocked that girls under 18 — and even under 16 — can get married in Alaska because they really are just girls," Gardner said. "They can't rent an apartment, they can't make a doctor's appointment, they can't open up a bank account, but they can get married? And even though the numbers of it actually happening here are really small, it's still wrong in my view."
Read more here: https://www.seattletimes.com/nation-world/lawmaker-seeks-to-up-alaskas-legal-age-of-marriage-to-18/
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Singapore Premier League Sports
10 goals as SPL resumes, fans show their support for teams from outside venues.
Mar 14, 2021 featured
Football fans were not allowed into the venues for the opening day matches but they turned up and showed their support for their teams at both the Jalan Besar Stadium and the Jurong East Stadium as opening day brought about a total of 10 goals to the record books.
At the Jalan Besar Stadium, fans were spotted at vantage points, while at the Jurong East Stadium, supporters could be seen milling around and watching the proceedings through the fences, with supporting banners and put up.
Photo: Hougang United FC Supporters club
And what better was for these fans, and those who watched the broadcast on social media and on cable to be rewarded with goals and more goals.
Gabriel Quak's opened his goal account for the Lion City Sailors by coming up with a brace on opening day against Tampines Rovers but his goals were still not good enough for the Lion City Sailors as they're held to a 3-3 draw by the Stags at the Jalan Besar Stadium.
Photo: AIA Singapore Premier League
The Sailors also did not field Diego Lopes and Jorge Fellipe – both its star signings – due to fitness issues.
The match at the Jalan Besar Stadium had been delayed for more than an hour due to the lightning warning system, but when it was cleared to start, the goals started raining in.
First it was Song Ui-young who put the Sailors up after just five minutes, before Quak adding another barely a minute later as he sent a pile-driver through from the outside of the box, a shot which Stags goalkeeper Syazwan Buhari.
But the Stags took the game to the Sailors despite going down a brace and found the net through Madhu Mohana, and all of this happened within 20 minutes of the match.
Photo: Tampines Rovers
Quak took the Sailors to 3-1 after the break, and just when it looked like the million dollar team from Singapore appeared to be cruising to their first win, their defence cracked open through schoolboy defending which allowed skipper Yasir Hanapi to score twice and level the scores to 3-3.
Tampines Rovers had the better of the exchanges, and were un lucky not to have taken all three points from the match.
In the other match, defending champions Albirex Niigata started their season with a 3-1 win over Hougang United.
Main Photo: Tampines Rovers
The 2021 Singapore Premier League season starts today. Our 6 predictions for the season.
SEA Games gold by "2027…latest 2029".


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LESSWRONG
Noticing Confusion
Absence of Evidence Is Evidence of Absence
byEliezer Yudkowsky12y12th Aug 2007109 comments
From Robyn Dawes's Rational Choice in an Uncertain World:
In fact, this post-hoc fitting of evidence to hypothesis was involved in a most grievous chapter in United States history: the internment of Japanese-Americans at the beginning of the Second World War. When California governor Earl Warren testified before a congressional hearing in San Francisco on February 21, 1942, a questioner pointed out that there had been no sabotage or any other type of espionage by the Japanese-Americans up to that time. Warren responded, "I take the view that this lack [of subversive activity] is the most ominous sign in our whole situation. It convinces me more than perhaps any other factor that the sabotage we are to get, the Fifth Column activities are to get, are timed just like Pearl Harbor was timed . . . I believe we are just being lulled into a false sense of security."
Consider Warren's argument from a Bayesian perspective. When we see evidence, hypotheses that assigned a higher likelihood to that evidence gain probability, at the expense of hypotheses that assigned a lower likelihood to the evidence. This is a phenomenon of relative likelihoods and relative probabilities. You can assign a high likelihood to the evidence and still lose probability mass to some other hypothesis, if that other hypothesis assigns a likelihood that is even higher.
Warren seems to be arguing that, given that we see no sabotage, this confirms that a Fifth Column exists. You could argue that a Fifth Column might delay its sabotage. But the likelihood is still higher that the absence of a Fifth Column would perform an absence of sabotage.
Let E stand for the observation of sabotage, and ¬E for the observation of no sabotage. The symbol H1 stands for the hypothesis of a Japanese-American Fifth Column, and H2 for the hypothesis that no Fifth Column exists. The conditional probability P(E | H), or "E given H," is how confidently we'd expect to see the evidence E if we assumed the hypothesis H were true.
Whatever the likelihood that a Fifth Column would do no sabotage, the probability P(¬E | H1), it won't be as large as the likelihood that there's no sabotage given that there's no Fifth Column, the probability P(¬E | H2). So observing a lack of sabotage increases the probability that no Fifth Column exists.
A lack of sabotage doesn't prove that no Fifth Column exists. Absence of proof is not proof of absence. In logic, (A ⇒ B), read "A implies B," is not equivalent to (¬A ⇒ ¬B), read "not-A implies not-B ."
But in probability theory, absence of evidence is always evidence of absence. If E is a binary event and P(H | E) > P(H), i.e., seeing E increases the probability of H, then P(H | ¬ E) < P(H), i.e., failure to observe E decreases the probability of H . The probability P(H) is a weighted mix of P(H | E) and P(H | ¬ E), and necessarily lies between the two.1
Under the vast majority of real-life circumstances, a cause may not reliably produce signs of itself, but the absence of the cause is even less likely to produce the signs. The absence of an observation may be strong evidence of absence or very weak evidence of absence, depending on how likely the cause is to produce the observation. The absence of an observation that is only weakly permitted (even if the alternative hypothesis does not allow it at all) is very weak evidence of absence (though it is evidence nonetheless). This is the fallacy of "gaps in the fossil record"—fossils form only rarely; it is futile to trumpet the absence of a weakly permitted observation when many strong positive observations have already been recorded. But if there are no positive observations at all, it is time to worry; hence the Fermi Paradox.
Your strength as a rationalist is your ability to be more confused by fiction than by reality; if you are equally good at explaining any outcome you have zero knowledge. The strength of a model is not what it can explain, but what it can't, for only prohibitions constrain anticipation. If you don't notice when your model makes the evidence unlikely, you might as well have no model, and also you might as well have no evidence; no brain and no eyes.
1 If any of this sounds at all confusing, see my discussion of Bayesian updating toward the end of The Machine in the Ghost, the third volume of Rationality: From AI to Zombies.
Your Strength as a Rationalist
118 comments86 points
Conservation of Expected Evidence
77 comments105 points