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Defense Agency
Marketing for Defense Companies
State clears $1.5 billion in arms sales for Egypt, South Korea and Canada
[ad_1] WASHINGTON — The U.S. State Department today cleared a trio of weapon sales for Egypt, South Korea and Canada, which could net American firms more than $1.5 billion in revenues. Announcements for the three deals were published online by the Defense Security Cooperation Agency. DSCA announcements are not final sales; if cleared by Congress, contract figures can change during future negotiations. The largest of the three agreements is with… Read More »State clears $1.5 billion in arms sales for Egypt, South Korea and Canada
Hyten denies sexual assault accusations, but new questions cloud his confirmation
[ad_1] Senior military officials and key Senate Republicans rallied around President Donald Trump's pick for next Vice Chairman of the Joint Chiefs of Staff on Tuesday by flatly dismissing sexual assault allegations leveled against him by a former aide. Gen. John Hyten, the current head of U.S. Strategic Command, called the claims against him false and insisted that "nothing happened, ever" with Army Col. Kathryn Spletstoser, a senior member of… Read More »Hyten denies sexual assault accusations, but new questions cloud his confirmation
The next cybersecurity concern for NATO? Space
[ad_1] A new report warns that the cybersecurity vulnerabilities related to military space systems, specifically terminals and command-and-control systems, deserves renewed attention from NATO countries. The report, titled "Cybersecurity of NATO's Spaced-based Strategic Assets," was produced by Chatham House, which is part of the Royal Institute of International Affairs, a policy institute in London. The paper, by Beyza Unal, was released July 1. "There is an urgent need to study… Read More »The next cybersecurity concern for NATO? Space
A last chance for Turkey? There could still be time to fix the S-400 issue
[ad_1] Russian President Vladimir Putin is on the verge of a major diplomatic victory in his efforts to divide the NATO alliance. Delivery of the first elements of the Russian S-400 air defense system to Turkish President Recep Tayyip Erdogan and Washington's correct decision to halt delivery of F-35 jets bound for Turkey in response may set off a chain of events that could even lead to Turkey's withdrawal from… Read More »A last chance for Turkey? There could still be time to fix the S-400 issue
Money for nothing: PODCAST
[ad_1] "You're wrong, your feelings are wrong, and your opinion is wrong." On this week's Defense Nerds Podcast, Military Times Deputy Editor Leo Shane and Defense News Capitol Hill Bureau Chief Joe Gould talk about the new two-year, $2.7 trillion budget deal that will give the Defense Department a 3 percent raise for fiscal 2020. Not surprisingly, not every lawmaker is happy. The hosts also look at the rush of… Read More »Money for nothing: PODCAST
The Defense News Top 100 revealed
[ad_1] About Jeff Martin Jeff is Defense News's Associate Editor for Multimedia, coordinating multimedia coverage for the brand. He's the host of Defense News Weekly, the premier television show covering the defense industry and U.S. military, airing on PBS and AFN worldwide.In addition, he produces the show and covers stories worldwide, across Defense News's portfolio. [ad_2] Source link
Canadian fighter competition takes off
[ad_1] The timeline is set for Canada's competition to field new fighters and the field is diverse and ready to go. [ad_2] Source link
Thailand approved to acquire Stryker infantry carriers
[ad_1] MELBOURNE, Australia — The U.S. State Department has approved a possible foreign military sale to Thailand of 60 Stryker infantry carrier vehicles, potentially making the southeast Asian kingdom the first non-U.S. user of the wheeled armored vehicle. The Defense Security Cooperation Agency issued a notification to Congress of this possible sale on July 26, 2019. It would also include equipment and support, with an estimated cost of $175 million.… Read More »Thailand approved to acquire Stryker infantry carriers
Esper takes over Pentagon
[ad_1] Arm Secretary Mark Esper is now secretary of Defense, the first confirmed leader of the department since James Mattis departed. [ad_2] Source link
An up-close look at Talisman Saber 2019
[ad_1] Defense News gets a close look at refueling operations during Exercise Talisman Saber 2019. [ad_2] Source link
Blue Origin wins protest against Air Force procurement plan
US Space Command is here. Now where does it need to go?
Why Amazon can afford to be defiant
US urges Turkey to keep its $2.5 billion air defense system packed away
China's Achilles' heel when it comes to cyberspace


Monthly news bulletin issue 10/2017.
Welcome to our October newsletter from the Lloyd's Register Foundation. It's packed full of interesting updates along with a forward look at events in the pipeline. Did you know that we've just been named the number one Foundation in the UK in terms of grants giving? Did you know that we're working on assuring the safety of the world's largest 3D printed metal structure? Well read on and you'll find out all about these. Good reading.
Lloyd's Register Foundation at #1!
The Association of Charitable Foundations (ACF) has published its annual 'Giving Trends' report on grant activity across the UK, and it reflects a fantastic year for Lloyd's Register Foundation. As a foundation, we seek to maximise our impacts through a blend of mixed motive investments and a complex grant programme centred on our strategic themes. It is this grant activity that the ACF has highlighted in its 2017 Report, showing that we are now in the top-ten of grant givers in the UK (by size of grants made) with £31.9M awarded in the year up to June 2016. The ACF has chosen to define us as a 'corporate foundation' (due, no doubt, to our strong ties with the Group), and in the 2017 report we are delighted to be positioned at the top of the table in this category. The full report can be found here with pages 18-19 featuring the Foundation.
The world's largest metal 3D printed structure is under construction in Amsterdam; a pedestrian bridge that will be installed over one of Amsterdam's canals and will be opened to the public in 2018. The Foundation has awarded a grant to MX3D, the people behind the bridge that will use sensors and big data to create a living laboratory that demonstrates the bridge's ongoing safety, provides feedback for future design improvements, adds to resilience studies of Amsterdam and generates open data. MX3D has leveraged our funding creating a consortium that that now includes The Turing Institute amongst others. Photo credit Olivier de Gruijter.
The Mayor of London, UK, Sadiq Khan, has this week started a two-year collaboration with the prestigious Alan Turing Institute to explore ways to improve how air quality is modelled in London by collating existing and new data sources and enhancing the way it is analysed.
The work with the Alan Turing Institute will complement the Mayor's existing work with other major London institutions, such as King's College London, who work with boroughs and City Hall to undertake local air quality monitoring and to develop the London Atmospheric Emissions Inventory. It is taking place as part of the Turing-Lloyd's Register Foundation programme in data-centric engineering, which aims to use data science to transform the safety and efficiency of complex infrastructure systems. .
Research and innovation in science and technology is vital to solving the economic and societal challenges of our world, including improving the safety of critical infrastructure and our interaction with it. These solutions often require access to high quality research equipment and infrastructure.
The Foundation has recently opened a call for applications from researchers that require access to research infrastructure in support of studies leading to improved safety of life and property. The primary goal is to support researchers who would benefit from accessing world-class research infrastructure that is not available in their host institution or country and where the funding schemes available in their country of residence does not facilitate such access.
This call will further enable the Foundation to achieve its strategic goals of supporting excellent scientific research, and accelerating its application whilst ensuring maximum impact is derived from its grants.
15-18 January 2018: Lloyd's Register Foundation Institute for the Public Understanding of Risk (LRFI) at the National University of Singapore is offering fellowships to professionals from developing countries in Asia to attend an executive education programme "Understanding and communicating risks: Facts, fears and fallacies" in Singapore. For more information see here.


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Don't Spread My Wealth
Home News Lev Parnas Asks Barr to Recuse Himself From Criminal Case
Lev Parnas Asks Barr to Recuse Himself From Criminal Case
Lawyers for Lev Parnas, the Soviet-born businessman who was involved in the campaign to pressure Ukraine to investigate political rivals of President Trump, asked on Monday that Attorney General William P. Barr disqualify himself from overseeing his criminal case because he has too many conflicts of interest.
Mr. Parnas, who was charged in October in Manhattan with violating federal campaign finance laws, requested that a special prosecutor instead be appointed to handle his case.
"It is in the public interest to remove this matter entirely from the Department of Justice," Mr. Parnas's lawyers wrote to Mr. Barr.
The lawyers, Joseph A. Bondy and Stephanie R. Schuman, argued that federal prosecutors working for Mr. Barr should not be involved in his case because Mr. Barr had participated in some of the same activity for which Mr. Parnas was being investigated.
They asked that a special prosecutor be appointed from outside the Department of Justice.
The Justice Department and the United States attorney's office in Manhattan, which is prosecuting the case against Mr. Parnas, each declined to comment on the lawyers' request.
In their letter, the lawyers listed several potential conflicts for Mr. Barr, including that the transcript of Mr. Trump's telephone conversation with President Volodymyr Zelensky of Ukraine on July 25, 2019, contained multiple references to Mr. Barr — along with Rudolph W. Giuliani, the president's personal lawyer — "as being the point person for the Zelensky administration to work with in commencing an investigation into the president's chief political rival," former Vice President Joseph R. Biden Jr.
The letter also cited a reference to Mr. Barr in the Aug. 12 whistle-blower complaint that helped set off the impeachment inquiry against Mr. Trump. The complaint alleged that Mr. Barr "appears to be involved" in the pressure campaign.
Mr. Barr has not been accused of wrongdoing.
The letter was included in a filing before Judge J. Paul Oetken of Federal District Court in Manhattan, who is overseeing Mr. Parnas's case. Mr. Bondy wrote that he had sent the letter to Mr. Barr on Monday afternoon.
Mr. Bondy, in a brief phone interview, said it would be appropriate for a special prosecutor, if appointed, to determine "to what extent to continue to rely upon" members of the Justice Department in Washington or the prosecutor's office in Manhattan in the continuing investigation of Mr. Parnas.
It was unclear what legal recourse, if any, Mr. Parnas's lawyers would have if Mr. Barr refused their request, seemingly a legal long shot.
The request comes as Mr. Parnas has catapulted to the center of Mr. Trump's impeachment proceedings.
Over the last week, House Democrats have released a trove of Mr. Parnas's text messages with Mr. Giuliani and other players in the Ukrainian pressure campaign. The records, which Mr. Parnas shared with the House Intelligence Committee, showed the extent of his involvement in the campaign, contradicting Mr. Trump's allies who have portrayed Mr. Parnas as a peripheral player, and spurring calls for him to testify at the Senate impeachment trial.
Mr. Parnas also has gone on something of a publicity tour, granting interviews to the MSNBC host Rachel Maddow and The New York Times and taking aim at the president. In his interview with The Times, he said, "I am betting my whole life that Trump knew exactly everything that was going on that Rudy Giuliani was doing in Ukraine."
Mr. Trump has denied knowing Mr. Parnas, and the White House has dismissed his comments as self-interested lies told by a criminal defendant.
The lawyers also said in the letter that federal prosecutors in Manhattan had refused to meet with Mr. Parnas "and receive his information" regarding Mr. Trump, Mr. Giuliani and others, "all of which would potentially benefit Mr. Parnas if he were ever to be convicted and sentenced in his criminal case."
Mr. Bondy told The Times last week that his client was seeking to cooperate with the federal prosecutors in Manhattan. "We very much want to be heard in the Southern District," Mr. Bondy said. "We very much want to provide substantial assistance to the government."
A formal cooperation deal, if granted by the government, can lead to a defendant's receiving leniency when he is sentenced.
In the criminal case against Mr. Parnas, he and an associate, Igor Fruman, were arrested at Dulles International Airport as they prepared to board a flight to Frankfurt with one-way tickets.
According to a federal indictment unsealed on Oct. 10, Mr. Parnas and Mr. Fruman illegally routed a $325,000 contribution through a shell company to a political action committee that supported Mr. Trump.
Mr. Parnas and Mr. Fruman have pleaded not guilty to the charges.
In addition to the campaign finance charges he already faces, Mr. Parnas is under scrutiny for his relationship with a former Ukrainian prosecutor, Yuriy Lutsenko. The federal prosecutors in Manhattan are examining whether Mr. Parnas — as well as Mr. Giuliani — acted as unregistered foreign agents while trying to convince the Trump administration to remove the American ambassador to Ukraine, Marie L. Yovanovitch, who was at odds with Mr. Lutsenko.
Mr. Giuliani has not been accused of any wrongdoing and has said that he was acting on behalf of his client, Mr. Trump, not Mr. Lutsenko.
Katie Benner contributed reporting. Alain Delaquérière contributed research.
Continue reading at New York Times
DSMW
Drowned Out by Noise, These Horny Frogs Wave Their Arms and Legs to Get Noticed
Feds walk back claims Capitol rioters meant to 'capture and assassinate' elected officials
Jerry Springer Just Weighed in on the Replacing Kim Cattrall in Sex and the City's Revival Debate
Kristin Cavallari Has the Best Response to Critics of Her Parenting
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Drowned Out by Noise, These Horny Frogs Wave Their Arms and Legs to Get...
News DSMW - January 15, 2021
A species of Ecuadorian glass frog combines high-frequency croaking and a striking visual display to attract mates, in what is a fascinating adaptation to a noisy environment.Read more......
"Strong evidence, including Chansley's own words and actions at the Capitol, supports that the intent of the Capitol rioters was to capture and assassinate elected officials in the United States Government," the filing stated. ...
Jerry Springer Just Weighed in on the Replacing Kim Cattrall in Sex and the...
Judge Jerry Springer presiding. Yes, you read that right. Daily Pop's set was transformed into a courtroom on Friday, Jan. 15, allowing the former host of The Jerry Springer Show to... ...
Feds walk back claims Capitol rioters meant to 'capture and assassinate'...
Jerry Springer Just Weighed in on the Replacing Kim Cattrall in...

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Ajax : Get rid of unwanted text with data I'm trying to get the new data from controller every 10 seconds. but the ajax return unwanted text that comes with the data. Is there anyway to get rid of the text that comes with data? I'm sorry about my English
Here the result that showing on the page

i only want the number "1077" and "7"
This is my controller
ajax: function(req, res){
    knex.raw("CALL GetQueuePlay('00');")
     .then(function(result){
        var number = JSON.parse(JSON.stringify(result[0][0]));
        console.log(JSON.parse(JSON.stringify(result[0][0])))
        return res.send({q_play_list:number});
      })
},

and this is Ajax
$(document).ready(function(){
    setInterval(function(){
    $.ajax({
        type: "GET",
        url: "/ajax",
        data: { QNum: 0 , station_num: 0 },
        success: function(data){
            $('#kue1').text(JSON.stringify(data));
            console.log('Data Appeared!' + data);
        },
        error: function (error) {
            console.log("something is wrong: ", error);
        }

    });
},10000)
});

A: You can try
Object.values(q_play_list[0])

Or, you can use regex to filter out the non digit characters if that ever happens.
https://www.w3schools.com/jsref/jsref_obj_regexp.asp

A: As I can see q_play_list is an array. On receiving the response, you can loop through the array and read the properties QNum and station_num, store it in variable and then display it in the UI. Like so:
    if(data["q_play_list"] && Array.isArray(["q_play_list"])){
         var playList = data["q_play_list"];
         var playListLength = data["q_play_list"].length;
         for(var i = 0; i< playListLength; i++){
           var textToBeDisplayed = playList[i].QNum || "";
           textToBeDisplayed + = playList[i].station_num? " "+playList[i].station_num : "";
           $('#kue1').text(textToBeDisplayed );
         }
    }

redpajama_set_name: RedPajamaStackExchange


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Namie Amuro and Hatsune Miku Collaboration Song Announced
Posted by Mercuryw at 10:17 pm Hatsune Miku, Music, Other 3 Responses »
An official announcement came today announcing a collaboration song from two big idols of Japan: Namie Amuro and Hatsune Miku, under the title "B Who I Want 2 B". The song is produced by UK underground artist Sophie, with lyrics co-wrote together with Michie M.
At the peak of her popularity, Namie Amuro was widely recognized as "Teen Queen", "Queen of J-Pop" or even "Japanese Madonna". Her collaboration with Hatsune Miku was previously held a secret, as the title was released as "B Who I Want 2 B feat. U hum sneak it" (anagram). What followed after were the released preview and commercial with no vocal audio in them, which slowly stirred up curiosity and suspicion among the community. Until today, that is.
The main visual was done by illustrator Shigenori Soejima, who is best known in the community for his works in Persona 3, Persona 4, Catherine and the upcoming Persona 5. The song is part of the album _genic which will soon release on June 10th. For more details on the album please visit the official website: http://dimension-point.jp/amuro/_genic/
Below is the song preview, which was broadcast on TV earlier today (split into two parts):
New Album「_genic」収録曲「B Who I Want 2 B feat. HATSUNE MIKU」で初音ミクとコラボ決定!
▶ めざましテレビ (1/2) pic.twitter.com/5pQkVDoXIF
— まいまい♡n.a. (@NAMIEternal) June 8, 2015
▶ めざましテレビ (2/2) pic.twitter.com/kRqLB1YZv4
https://www.youtube.com/watch?v=Y2V_Y26JTSw


A stylish choice for living your life in style! The Myrtle - a brand new 2 bedroom plus study home within our Ingenia Lifestyle Hunter Valley over 55s community.
The Myrtle features a lovely timber deck that looks out on the garden, perfect for that morning cup or afternoon wind down. It's spacious, smart-by-design, affordable and finished to a high-quality. It's a great home to own and Ingenia Lifestyle Hunter Valley is a wonderful place to live!
Located for your comfort and convenience, Ingenia Lifestyle Hunter Valley is on Mount View Road. Only a 4-minute drive to shopping districts, close to cafes, medical facilities, clubs/pubs and restaurants! You'll enjoy having the world class food and wine region right on your doorstep.
Ingenia Lifestyle Hunter Valley- Contact Jenni Jones today.


ASCRS' The Voice of Ophthalmology Wants You!
This is your opportunity to take center stage!
Submit your audition video for the chance to become a contestant in Season 2 of ASCRS' The Voice of Ophthalmology!
May not exceed 30 seconds.
Tell us why you should be on ASCRS' The Voice of Ophthalmology, Season 2.
Describe your proposed controversial topic in anterior segment surgery; view 2018 topics to use as inspiration.
Explain why you think your controversial topic in anterior segment surgery is suitable for debate with an expert panel.
Submit via text to 703-717-3770 or email to ASCRSVoice@ascrs.org.
Submissions accepted from Nov 12–Dec 14, 2018.
Contestants will be selected by the coaches based on the educational value, relevance of the topic and knowledge and command of the issues.
Session attendees will vote to select the winning case during the session.
REGISTER TODAY FOR THE 2019 ASCRS•ASOA ANNUAL MEETING!
Must be a current ASCRS member to attend.


Eco-friendly promotional pens made from recycled cardboard with neutral coloured tip, clip and button. Ideal for environmentally conscious businesses, these custom branded pens are for those who want to stick to their values in everything they do.
Please note: Due to the cardboard construction of this pen, small imperfections may occur.
Very fast turnaround, product exactly as described.
Excellent product and great (and friendly) service overall.
We have bought these pens before from another supplier. You were cheaper however!


The Book of the Week is "Tales from the Dugout" by Mike Shannon, published in 1997. This lighthearted compilation of anecdotes mentions some of American professional baseball's colorful characters of different eras.
It was a dirty little secret that Willie Mays deliberately wore an oversized cap so that it fell off for a more dramatic effect when he was making one of his legendary catches in the field.
In April 1991, the J. Fred Johnson minor league stadium was cleaned up after a game via crowd-sourcing of the fans, who, in compensation, had received free admission.
Earl Weaver, manager of the Baltimore Orioles in the 1970's and 1980's, got thrown out of 91 games for arguing with the umpires. Needless to say, he was a hothead. One time, he made good on his threat to pull Orioles pitcher Rick Dempsey out of a game. Dempsey was so enraged, he threw his protective gear at Weaver in the locker room, and as their shouting match continued, got Weaver all wet when he turned on the shower.
Read the book to learn of other amusing episodes.


Since 2002 when the Fabre family took over Château d'Anglès they have succeeded in revealing the true potential of this vineyard, and now have a range of award-winning wines to show for their enthusiasm and commitment. With a lifetime in wine making, Eric Fabre's career includes eight years as Technical Director of the world-renowned Château Lafite Rothschild. It was however, a lifelong dream to own a vineyard on the Mediterranean, so 2001 saw Eric and his wife Christine seduced by the Château d'Anglès. The beautiful ancient stone 'mas' farmhouse of Château d'Anglès overlooks the vines that slope gently down to the shores of the Mediterranean.
Deep red colour with hints of black. Complex bouquet with a blend of ripe red and black fruits, spices, liquorice and tobacco flavours highlighted by the typical minty touch of La Clape. Full-bodied and elegant mouth structured by dense and remarkably silky tannins. Great length endowed with a nice freshness.
Food Pairing Wonderful with game and red meat. Try it with a serious T-bone!
Total de-stemming, juice is gravity-fed into vats, traditional temperature-controlled fermentation. Very long maceration (50 days) with no trituration so as to extract only the finest elements.
Syrah and mourvedre are blended then nursed in 3-4 year old barrels for 10 months. Grenache is aged in vat to preserve its fruit. Natural stabilisation, static clarification by gravity, no fining or filtrating.
Soil/Vines Hard limestone of the mountain of La Clape. Warm and dry climate tempered by the Mediterranean. Slow ripening thanks to cooler nights on the shores of the sea. Sustainable practices according to ASCERT charter for respect of the environment and complexity of the wine: composted pomace amendment, crushed unwanted shootes, plowing, biodegradable sprays, no insecticides.
Harvest Two-months-long picking according to maturity of each variety, grapes are hand-selected.
Ageing Potential Fresh and fruity when young, gaining more complexity after 5-10 years.
"Deep in the glass-expect something slightly formidable. Expressive but contrite, dried herbs, aromas of the hills not wine grapes, smells are in sync with its environment, no variety is dominating. There is nothing more to neither prove nor sniff now that it has your interest, just drink.
Well, think about the palate first. A wine with front, look to see it coming because here is some real texture. A wine with body, an insult to the mouth until the tremor subsides. Mourvedre talking, but slowly slipping away from the effects of syrah, and finally the grenache creates silk. Just nice to drink for 40% mourvedre, 40% syrah, 20% grenache. A Languedoucienne marvel, high value, made by a man who once fiddled with cabernet (in Bordeaux). Drinkers - enjoy the effect of low cropping in the glass, the black fruits of mourvedre and a grand wine articulating its terroir.
This is outstanding; just so together."


360Life Church, Stockport > News & Updates > News > Update > Operation Christmas Child: The Results Are In!
Thank you to everyone who filled a shoebox for this year's appeal.
Church gave 47 boxes all together! Well done everyone.


text:
Q: How to Change print_r button name using javascript I have a code i directly copied from php documentation site. The code enables me to print "print_r" function in a readable format. The code is below
    function print_r_tree($data){
    // capture the output of print_r
    $out = print_r($data, true);

    // replace something like '[element] => <newline> (' with ...

        $out = preg_replace('/([ \t]*)(\[[^\]]+\][ \t]*\=\>[ \t]*[a-z0-9 \t_]+)\n[ \t]*\(/iUe',
    "'\\1<button onClick=\"javascript:toggleDisplay(\''.(\$id = substr(md5(rand().'\\0'), 0, 7)).'\');\">
            \\2
             </button>
'",
        $out);

    // replace ')' on its own on a new line (surrounded by whitespace is ok) with '

    $out = preg_replace('/^\s*\)\s*$/m', '
', $out);

    // print the javascript function toggleDisplay() and then the transformed output
    echo ''."\n
$out
";
}

The Code above output three buttons like [ [0] => Array ], [ [1] => Array ] and [ [2] => Array ].
But I want the button to be outputted in the Following format [Good], [Average], and [Worst]. I have tried to change the "\2" in the text on the button to the JavaScript snippet below
$out = preg_replace('/([ \t]*)(\[[^\]]+\][ \t]*\=\>[ \t]*[a-z0-9 \t_]+)\n[ \t]*\(/iUe',
    "'\\1<button onClick=\"javascript:toggleDisplay(\''.(\$id = substr(md5(rand().'\\0'), 0, 7)).'\');\">
//Writing Javascript code to display buttons instead of "//2"

             </button>
'",
        $out);

But it is giving me regex and identifier errors. What can I do about this please.

A: Blindly copying some random code snippet from a php.net documentation comment isn't a good approach on anything. Especially if you apparently don't know what you're doing. Understand what you're doing.
That being said. Why not change the $data array before it is print_r'ed?
$data = ['Good' => $data[0], 'Average' => $data[1], 'Worst' => $data[2]];


text:
Sunny to partly cloudy. Hot and humid. High near 100F. Winds SSW at 15 to 25 mph..
Calvin Woodworth
Funeral services for Calvin Van Kirk Woodworth of Minco will be held at 10 a.m. Monday at First Baptist Church in Minco. Services are under the direction of Huber-Reynolds Funeral Home.
Mr. Woodworth died July 3, 2019, in Yukon. He was born Sept. 18, 1932, in Minco. Calvin was raised in the Minco community and graduated from Minco High School in 1950. He served in the U.S. Army National Guard during the Korean Conflict, earning a Bronze Star.
He ran Woodworth's Hardware Store in Minco for 40 years. Calvin was a member of Minco First Baptist Church, Grady Memorial Hospital Board and the Gideons.
Calvin is survived by his wife, Deanie of El Reno; son, Brent Woodworth of Minco; daughter, Caleta Duncan of Yukon; sister, Patricia McKelvey of Minco; nine grandchildren and 17 great- grandchildren.


text:
Q: Can't query GeoPackage geometry via SQLite client I have a GeoPackage and I want to select the geometry as text from the SQLite command-line client. Here's what I've done:

*

*Run sqlite3

*Load SpatiaLite with .load /path/to/mod_spatialite.dylib (I'm on a Mac)

*Run the following query:

sqlite> select astext(geom) from boundary;

There aren't any errors, but the client prints a blank newline as the result.
Am I doing something wrong, or can anyone think of other diagnostics?
I'm new to SpatiaLite/GeoPackage.
The layer loads fine in QGIS! The geometry looks fine. It's one big multipolygon.

A: Geometries in SpatiaLite are not encoded in the same way than geometries in GeoPackage. The AsText/ST_AsText function needs a SpatiaLite geometry as an input. The function returns NULL for GeoPackage geometries because it does not understand what they are.
However, SpatiaLite has a function "CastAutomagic" that converts GeoPackage geometries into SpatiaLite geometries. Add the function into your query and it will handle the GeoPackage geometries.
SELECT AsText(CastAutomagic(geom)) from boundary;

See the manual of the SpatiaLite functions https://www.gaia-gis.it/gaia-sins/spatialite-sql-latest.html.

CastAutomagic
This function will indifferently accept on input:

*

*a SpatiaLite own BLOB Geometry

*a GPKG own BLOB Geometry

then returning a SpatiaLite own BLOB geometry.


text:
Q: upgrade oracle apex 19.1 to 19.2 on centOS maybe someone knows what the problem is, I had an apex 19.1 (expanded on a centos ), I decided to upgrade to 19.2. I was following this link https://docs.oracle.com/en/database/oracle/application-express/19.1/htmig/upgrading-to-latest-AE-release.html#GUID-4B4A2BDC-11AA-4ACF- 88B2-E320D6361596 . But there was a problem. Almost immediately after @ apexins.sql, the disconnect from the oracle
I use XE18. Even before updating to the new version, I deleted the apex folder with apex 19.1 and instead unzip the apex folder with 19.2


text:
Clarifications regarding COVID-19 testing guidance
by Reopening Operations Committee, September 21, 2020
The Reopening Operations Committee has received some questions from Willamette community members about the changes to the Center for Disease Control and Prevention's COVID-19 Testing Guidance highlighted in a recent New York Times article. The article highlights the changes to the CDC guidance to include the recommendation that testing of asymptomatic people was not necessary, even if they were exposed to the virus.
All clinics, hospitals, labs, and providers, including Bishop Wellness Center regularly receive the same testing guidance from the Oregon Health Authority: "COVID-19 Testing Guidance for Healthcare Providers," last updated on Aug. 14. For our context, OHA recommends that testing of people without symptoms is limited to close contacts of confirmed or presumptive COVID-19 cases. Bishop Wellness Center will continue to follow this guidance from the OHA. We are not aware of changes to this state guidance at this time.
We've also had some questions about why specific classes are not notified of a positive case.
As you know, Willamette has implemented several mitigation strategies in accordance with state guidelines to minimize virus transmission (e.g., mandatory use of masks, 6 feet of distance, box fans with filters in classrooms). In the event of a positive case, only those identified as "close contacts" (defined as less than six feet for more than 15 minutes) need to quarantine. Those who are identified as close contacts will be notified by a university official or a local county contract tracer. Because others would not be required to quarantine if 6 feet of distance is maintained, coupled with the need to protect individuals' private medical information, others in the class will not be notified when a person in the class tests positive.
Importantly, it's the privacy laws that prohibit us from fuller disclosure, rather than Willamette deciding not to disclose more detailed information about who has tested positive. If students and faculty maintain the necessary 6 feet of distance in classrooms, they are not "close contacts," will not need to quarantine, and will not be notified. This protocol was verified in a recent conference call with OHA, the Higher Education Coordinating Commission and Oregon Health Officer and State Epidemiologist Dean Sidelinger.
Willamette has broadly notified our community of all confirmed positive cases and shares that information on the Willamette website.


Polyarteritis nodosa (PAN) and Microscopic polyangiitis (MPA) are two vasculitides which were previously grouped together.
However, they are currently thought of as two separate entities.
PAN is a vasculitis of the medium-sized arteries, sparing the smaller vessels and therefore does NOT cause a glomerulonephritis. Any renal compromise which results is generally due to ischemia from inflammation of the medium-sized renal vessels. PAN is often associated with hepatitis B infection.
In contrast, MPA is a vasculitis of the small-sized vessels, and therefore results in a pauci-immune glomerulonephritis. It is very commonly ANCA-positive.
Infectious metastases (e.g., infective endocarditis, epidural abscess, liver & lung abscesses, etc) are unfortunately not uncommon in the ESRD population, particularly in those with in-dwelling catheters. I have personally seen several cases of epidural abscesses as a fellow, a complication which can be neurologically devastating and nearly impossible to treat. Clearly, prevention is the key issue.
A small but instructive case series from Kovalik et al in a 1996 issue of JASN reviewed all the cases of dialysis patients with epidural abscess over a 5-year period within the Duke health care system. Of the 10 patients identified, the majority (8) had catheters, 5 of whom with known bacteremia with an attempt to treat the infection with antibiotics alone. The lesson, if you haven't learned it by now: catheter-associated bacteremia virtually always should be treated with a line change, as there are significant risks to doing otherwise.
The M3 subtype of acute myelogenous leukemia--also known as acute promyelocytic leukemia--is one of the most responsive forms of leukemia, as the addition of all-trans retinoic acid (ATRA) is known to overcome the maturation block in affected lymphocytes.
While this is generally good news for leukemia patients with M3 disease, about 5-25% of patients get an ATRA-induced systemic illness termed "ATRA Syndrome". Symptoms are widely variable but can include fever, interstitial pulmonary infiltrates, pleural/pericardial effusions, and (the reason for its inclusion in this blog), acute renal failure. The topic has been a relevant one for me as there are currently two patients on the Renal Consult service I saw today with ATRA-induced renal failure. The mechanism is unknown but is posited to be due to mass release of cytokines by affected APL cells. It can be treated by holding the ATRA and administering corticosteroids.
Newly-Discovered Antigen for Membranous Nephropathy!
I went to a very memorable talk today at our Renal Grand Rounds during which fairly convincing data was presented that identifies the long-sought-after antigen which causes membranous nephropathy--still the most common cause of adult-onset nephrotic syndrome in whites.
The presenter (Larry Beck of Boston University Medical Center) described a fairly straightforward approach: he took serum from patients with membranous nephropathy and used it on Western blots of normal human kidney tissue. In about 70% of cases of idiopathic membranous nephropathy (but in 0% of cases of secondary membranous nephropathy and 0% of other nephrotic syndrome states such as FSGS and diabetic nephropathy), Western blotting reveals a 189kD band, which is identified as M-type phospholipase A2 receptor. We don't know much about the protein's function, but it does appear to be present in podocytes, and IgG4 antibody against this protein can be eluted from membranous nephropathy biopsy specimens. Interestingly, in some patients this 189kD band disappears after successful treatment with standard membranous agents, implying that an ELISA test may be an effective way of monitoring these patients (much like the ANCA is used for Wegener's granulomatosis, for instance).
The data is not yet published but chances are good it will end up in a high-profile journal soon.
IgA Nephropathy & Post-Strep Glomerulonephritis (PSGN) are both relatively common causes of glomerulonephritis which can both be associated with upper respiratory infections. How can you tell them apart?
One of the most important distinctions can be made in taking a good history: In PSGN, glomerulonephritis typically does not set in until several weeks after the initial infection. In contrast, IgA Nephropathy may present with so-called "synpharyngitic glomerulonephritis"--pharyngitis and glomerulonephritis at the same time.
In addition, PSGN classically presents with hypocomplementemia, and if the patient undergoes a renal biopsy there is evidence of an immune complex-mediated process. In contrast, IgA Nephropathy shows normal serologic values (though IgA levels may be elevated in about a third of patients) and the renal biopsy will show mesangial IgA deposition.
The juxtaglomerular apparatus (JGA) is located between the afferent arteriole and the returning distal convoluted tubule of the same nephron. It is responsible for regulating both intrarenal (tubuloglomerular feedback) and extrarenal (renin-angiotensin-aldosterone) mechanisms necessary to maintain both renal and entire body volume status.
(1) the juxtaglomerular cells of the afferent arteriole, synthesize and store renin, which is secreted in response to specific stimuli (e.g., low blood flow, decreased NaCl delivery). The juxtaglomerular cells could be considered the "effector arm" of the renin-angiotensin-aldosterone axis.
(2) the macula densa, a region of the distal convoluted tubule characterized by tubular epithelial cells which are more densely-packed than in other regions of the nephron (and thereby leading to its characteristic appearance on light microscopy). The macula densa can be considered the "sensory arm" of the renin-angiotensin-aldosterone axis in that these are the cells which sense decreased Na Cl delivery which determines downstream function. They are also involved in the mechanism of tubuloglomerular feedback.
(3) mesangial cells, which form connections via actin and microtubules which allow for selective vasoconstriction/vasodilation of the renal afferent and efferent arterioles with mesangial cell contraction.
The WAGR Syndrome is a rare genetic syndrome whose acronym stands for Wilms tumor, Aniridia (an absence of the iris), Genitourinary abnormalities, and mental Retardation. It is caused by a deletion of chromosome 17p.
The genitourinary abnormalities may take the form of gonadoblastoma (a gonadal tumor), or in boys hypospadias or undescended testicles. Occasionally (though not commonly) renal failure can accompany the syndrome. The fact that these individuals often get Wilms tumor is because the WT1 (Wilms tumor) gene, a tumor suppressor, lies on the deleted portion of chromome 17. A subset of individuals with the WAGR syndrome also have obesity--potentially due to whether the gene BDNF (brain-derived neurotrophic factor) is deleted or not.
The "ciliary hypothesis" refers to the idea that primary cilia--single, non-motile, microtubule-based structures which are found on the apical surface of renal tubular epithelial cells--play an integral role in the pathogenesis of polycystic kidney disease.
Scientists have long known about the existence of renal cilia; however, they felt up until the past decade or so that they were a "vestigial organelle" with no function. What changed? First, with the cloning and characterization of the two main genes for autosomal dominant polycystic kidney disease (PKD1 & PKD2), it was determined that the proteins which they encode localize in part to the cilia. Furthermore, a number of other rare pediatric diseases of cystic kidney formation (e.g., Bardet-Biedl Syndrome, nephronophthisis, ARPKD, etc) are also caused by mutations in genes which play an important role in the cilia.
Exactly how a loss of cilia function might result in cyst formation is still under investigation, but the current dogma states that as urine flows down the tubule, it bends the rigid cilia forward, thereby sending a signal to halt proliferation; if the cilia are not present, the signal is not sent, and cells continue to proliferate. This is a gross simplification, but this is the ciliary hypothesis in a nutshell.
The differential diagnosis for large kidneys (often demonstrated on renal ultrasound) is interesting, as there are a few conditions which are especially associated with this finding. Of course, with any type of chronic damage, the kidneys tend to scar down and atrophy.
3. the early stages of diabetic nephropathy.
4. any type of infiltrative process--classically amyloidosis or sarcoidosis of the kidney.
5. autosomal dominant polycystic kidney disease.
7. any type of very acute nephritis (e.g., RPGN).
The incidence of ANCA-positive disease is in the ballpark of 1:10,000. The incidence of anti-GBM disease is even more rare, at about 1:1,000,000. One would expect if these 2 disease-causing antibodies were entirely independent of one another, the incidence of a "double positive" (e.g., both ANCA & anti-GBM-positive) would be predicted to be (1:10,000 x 1:1,000,000 =) 1 in 10,000,000,000, or one in 10 billion.
Double positive disease is much more common than this, however. One study by Levy et al in a 2006 Kidney International paper showed that 5% of all ANCA-positive serum samples were also positive for anti-GBM antibodies, and about 1/3 of all anti-GBM positive samples had detectable ANCA. Most of the time (82%) the double-positive patients had an anti-MPO (myeloperoxidase) specific antibody. Perhaps not surprisingly, the double antibody-positive patients have a worse outcome than single-positive patients.
One theory to explain the existence of double-positivity is that the disease starts off as an ANCA-mediated process and damages the glomerular basement membrane, thereby exposing antigens to which an anti-GBM can form. Treatment in the acute setting is generally aggressive (e.g., treat them as if they have anti-GBM disease) and chronically is often managed as an ANCA disease.
The Ret gene plays an integral role in kidney development. As is covered in any basic embryology class, the cross-talk between the ureteric bud (destined to become the collecting system of the kidney) and the metanephrogenic mesenchyme (destined to become the renal parencyma and tubules) is a prime example of how reciprocal signals from two distinct tissue types can influence the development of the other. In the case of the kidney, GDNF (glial-derived neurotrophic factor) secreted by the mesenchyme interacts with the Ret receptor, a membrane tyrosine kinase, on the ureteric bud. This interaction is critical for branching morphogenesis, the process by which the kidney serially reiterates in order to create an organ with a million nephrons, as demonstrated by the fact that mice deficient in the Ret gene have a congenital absence of the kidney.
Ret is important other human diseases as well. It is a proto-oncogene, as gain-of-function mutations lead to various forms of multiple endocrine neoplasia (MEN). Loss-of-function mutations in contrast can lead to either Hirschprung's disease (a congenital absence of the enteric nerves) or renal hypoplasia.
The Brenner Hypothesis--developed by Barry Brenner of the Brigham and Women's Hospital, author of the well-known Brenner & Rector "The Kidney" textbook--states that individuals with a congenital reduction in nephron number have a much greater likelihood of developing adult hypertension and subsequent renal failure. This hypothesis is supported by the observation that there is a strong epidemiologic relationship between intrauterine growth retardation (IUGR)/low birth weight and adult hypertension. The mechanistic explanation for this phenomenon is that compensatory hyperfiltration by the remaining nephrons--similar to what happens in diabetic nephropathy--results in accelerated renal decline. While this theory is appealing at several levels, it does not explain everything: for instance, why most kidney transplant donors, who instantaneously lose 50% of their nephron mass, for the most part do well post-transplant without developing hypertension or renal disease.
The Brenner Hypothesis is part of a larger body of work which posits that many common adult diseases (including diabetes and hypertension) are caused by factors which are established during early growth and development, the "fetals origins of adult disease" hypothesis.
In 2003, the Fistula First Initiative was enacted, in which an attempt is actively being made to get as many dialysis patients as possible to get dialyzed via an AV fistula. As AV fistulas have been perceived to be the optimal form of dialysis access (with the longest life and fewest infectious complications), this policy seemed to make sense.
And while the initiative has achieved important benchmarks (>50% of dialysis patients using AV fistulas as of July 2008 according to the Fistula First website, with a recently revised goal to achieve 65% of prevalent patients using an AVF by 2009), there is some controversy regarding the project. The main issue is that while the # of patients with AV fistulas has increased, the # of patients with tunneled catheters (and its accompanying risks of infection) have also increased, as shown in this graph from Lok in a 2007 C-JASN review.
The reason for the increased use of catheters likely stems from the fact that there is an increasing rate of primary fistula failure--typically caused by failure to mature or thrombosis, possibly related to a sicker, more vasculopathic, aging population--and the decreased use of AV grafts. A recent KDOQI workgroup in 2006 re-emphasized that the goal of the Fistula First campaign should be a functional AV fistula, not simply the insertion of an AV fistula with a poor chance at maturing. As one vasscular surgeon at our hospital points out, the initiative should be "Patient First" rather than simply "Fistula First." In other words, the vascular access strategy should be individualized to the patient--meaning that for elderly, vasculopaths with poor native vessels who are anticipated to require dialysis in the near future, it may be appropriate to begin with a AV graft rather than attempting an AV fistula with little chance of success.
Once a frequent culprit of acute interstitial nephritis, vancomycin is a very rare cause of renal failure with newer formulations which use a different vehicle for its iv administration. It still however has the potential to cause the relatively common side effect of red man syndrome, a histamine-induced phenomenon in which there is the appearance of flushing, erythema, and potentially even hypotension and angioedema which occur during an infusion of this gram-positive antibiotic. This phenotype is due to mast cell (see accompanying electron micrograph) degranulation and is not an IgE-mediated allergic reaction. It can be treated by slowing down the rate of infusion (it is recommended to give a full dose over at least a 60-minute time period) and administering antihistamines.
Interestingly, red man syndrome appears to occur more frequently in healthy individuals (who are volunteering for drug studies) than in those with active infection; the thought here is that elevated baseline levels of serum histamine (as might be seen in active infection, which is an overall inflammatory state) are paradoxically desensitizing to the effects of vancomycin-induced histamine release from mast cells.
Vancomycin was originally isolated from a soil sample from the jungles of Borneo.
My friend from graduate school writes about a real-life personal experience with vancomycin-induced red man syndrome on her ABC Blog.
Neonatal lupus occurs when autoantibodies are transmitted from the mother to the fetus; it usually manifests as a transient and mild lupoid rash which lasts 3-6 months, but can also result in more serious manifestations such as congenital heart block, immune thrombocytopenia, cholestatic liver disease, or autoimmune hemolytic anemia. The autoantibodies anti-Ro (SSA) and anti-La (SSB) (also seen in Sjogren's Syndrome) are the culprits here; they are present in about 30% of SLE patients.
It is somewhat controversial whether or not pregnant women with lupus experience flares more frequently than their non-pregnant counterparts. Regardless, however, the issue of a lupus flare in a pregnant patient is not uncommon, especially considering that the disease tends to affect young females.
In general, the mainstays of treatment for lupus flares during pregnancy are AZATHIOPRINE and STEROIDS; both have had a pretty good track record for safety in pregnancy. Low-dose cyclosporin A may also be a consideration, and for patients in whom there is evidence of anti-phospholipid antibody syndrome, clot prophylaxis should be initiated with aspirin or low-molecular weight heparin.
Drugs specifically to be avoided in lupus pregnancies are CYCLOPHOSPHAMIDE (which unequivocally causes birth defects, especially during the 1st trimester) and MYCOPHENOLATE MOFETIL (which recently has been shown to result in ear and other facial malformations such as cleft lip and cleft palate).
It turns out that not only do gadolinium-based contrast agents result in nephrogenic systemic fibrosis (NSF), but certain ones can also interfere with some of the common assays for quantifying serum calcium, leading to sporadic hypocalcemia. The two widely used gado agents associated with this phenomenon are gadodiamide and gadoversetamide. It is especially true in patients with underlying renal insufficiency, as the gadolinium will hang around longer.
As a 2nd year nephrology fellow I am now doing some work in a lab which studies zebrafish kidney development. Here is an example of a control (wild-type) zebrafish at 54 hours post-fertilization.
If you use a morpholino (a form of antisense technology) to knock down a gene important for kidney function, you get massive edema after 3-4 days--as shown in the photos below. This is because zebrafish (a type of minnow native to India) live in freshwater, where the osmolarity is much lower than the intravascular osmolarity; with loss of renal salt and water homeostasis, volume overload ensues. This condition can be mitigated by putting the fish in saline water approximating the fish's endogenous osmolarity.
Cyclosporin A (CsA) has been a mainstay of therapy for nephrologists: it (along with tacrolimus) has become the cornerstone of immunosuppressant therapy for kidney transplant patients; in addition, it has also seen use as an effective agent in proteinuric disease states such as membranous nephropathy, FSGS, and minimal change disease.
The mechanism by which CsA acts as an immunosuppressant is well worked out: it binds to and inhibits calcineurin, an intracellular phosphatase, and thereby prevents the transcription factor NFAT from translocating to the nucleus and upregulating IL-2 transcription.
However, new data presented in a recent Nature Medicine paper suggests an entirely new mechanism by which CsA acts in the treatment of nephrotic syndrome: it tightens up the actin cytoskeleton of the podocyte which is required for maintaining a working slit diaphragm. In this paper, the authors demonstrate that CsA blocks the calcineurin-mediated dephosphorylation of synaptopodin, a protein in podocytes which regulates the actin cytoskeleton. As mentioned recently in this blog, we know already know that the actin cytoskeleton is critical for maintaining the filtration barrier as genes such as alpha-actinin 4 when mutated result in congenital FSGS.
Heavy metals & the kidney are an interesting topic all-around. Aberrant metabolism of heavy metals such as iron, copper, lead all contribute to significant renal pathology. And you can add the heavy metal cadmium to that list as well.
Cadmium toxicity is most notably manifest as renal tubular impairment, specifically in the proximal convoluted tubule, though it may also result in hepatotoxicity and osteoporosis.
Normal cadmium handling begins in the liver, where it binds to the small molecular weight protein metallotheionein. The metallotheionein-cadmium complexes are freely filtered at the glomerulus, then gets taken up at the proximal tubule by pinocytosis. The metallotheionein-cadmium complexes are degraded in lysosomes and excess cadmium is excreted into the tubular lumen via a specific transporter. Large amounts of cadmium can overwhelm this system and lead to proximal tubular damage. Not surprisingly, this results in a Fanconi's Syndrome which can include a proximal (type II) RTA, glucosuria, phosphaturia, and amino aciduria. One of the ways in which subtle proximal tubular damage via cadmium can be monitored is to look for urine b-2 microglobulin levels, which are handled in the PCT via a similar mechanism as metallotheionein.
Quick case summary as presented in Renal Grand Rounds today: A 54 year-old man presents with altered mental status, a sky-high ammonia level (>200) and anemia requiring blood transfusion. Other unusual lab values include hypophosphatemia and hypokalemia with a significant non-anion gap metabolic acidosis. Subsequent workup reveals 3+ glucosuria and aminoaciduria. What's the underlying diagnosis?
-myeloma is the cause of his anemia.
-myeloma and other paraproteinemias are a major cause of adult-onset Fanconi's Syndrome, which this patient has, as demonstrated by his aminoaciduria, glucosuria, phosphaturia, proximal renal tubular acidosis.
Adynamic bone disease is being increasingly recognized as the most common form of renal osteodystrophy. It is characterized by the reduced synthesis of bone matrix due to decreased osteoblastic and osteoclastic activity. Adynamic bone disease is distinct from osteomalacia, in which osteoid (the bone protein matrix, composed primarily of type I collagen) accumulates due to a lack of osteoblast activity or defective osteoid mineralization, as opposed to the simple decreased rate of turnover seen in adynamic bone disease.
Adynamic bone disease is particularly common in the peritoneal dialysis population in that the constant exposure to calcium in the dialysate fluid leads to episodic hypercalcemia and suppression of PTH levels which results in adynamic bone. A 2006 study by Haris et al in Kidney International randomized PD patients with adynamic bone disease (as assessed by bone biopsy) to normal Ca (1.62mM) versus low Ca (1.0mM) dialysate. The low-Ca dialysate group developed a higher PTH and bone turnover rates within the normal range, suggesting that the low Ca dialysate strategy is a good one for PD patients in order to avoid adynamic bone.
Water as therapy for PKD?
There are several clinical trials regarding the slowing of progression of polycystic kidney disease currently being conducted; amongst the drugs being studied are V2 receptor antagonists. The rationale for this is that cyclic AMP (cAMP) is known to be required for cyst growth; as ADH signaling involves an elevation of intracellular cAMP levels in the collecting duct, V2 receptor antagonists (e.g., the "vaptans") would be predicted to lower intracellular cAMP concentration and thereby lead to decreased cyst growth.
An even more economic treatment logically presents itself: drink more water! It is not known whether or not this would have a long-term benefit, but the recommendation to drink 3L of water a day (a recommendation which is fairly routine for stone-formers) would be predicted to decrease ADH levels by approximately 50%.
PKD patients also should be advised to avoid health products which contain forskolin--a potent stimulator of cAMP, which would therefore be predicted to accelerate cyst growth. Forskolin is an ingredient in various bodybuilding supplements and other non-FDA-regulated health care products.
Dialysis adequacy is traditionally measured as either Kt/V (most popular in outpatient dialysis units) or urea reduction ratio (URR, most popular with acute dialysis/inpatient dialysis units). Both methods use the degree to which urea is cleared--by comparing the urea concentration before and after dialysis--as the central means by which adequacy is determined. Regardless of which method is chosen, the means by which these values are obtained is vitally important.
The "pre-dialysis" BUN should be drawn before dialysis is actually begun. It's okay to hook the patient up to the machine, but the blood sample should be drawn before the actual treatment is begun.
The "post-dialysis" BUN must be drawn in a manner described in the KDOQI Guidelines. The blood is drawn from the arterial line at the end of the treatment; one of the main risks here is that there is always some degree of access recirculation, in which some percentage of just-dialyzed blood makes it back into the arterial line. This will have the effect of artificially lowering the post-dialysis BUN, and can lead to falsely high URR or Kt/V readings. To avoid access circulation problems, the dialysis nurse should slow down the blood flow through the dialyzer to a rate at which access recirculation is negligible. Generally, a blood flow of 100 mL/min for 15 seconds is enough to clear the blood occupying the "dead space" of access plus tubing.
Congenital nephrotic syndrome only makes up between 2-8% of all forms of nephrotic syndrome, but is a hot topic in that there are numerous genes continuously being identified which are helping to advance our understanding of podocyte biology.
1. nephrin (NPHS1): this was the first gene identified which causes congenital nephrotic syndrome of the Finnish type. As shown in the cartoon above, nephrin is a major component of the slit diaphragm.
2. podocin (NPHS2): this was the next gene identified and is the most commonly mutated gene causing steroid-resistant nephrotic syndrome.
3. WT1: this is the Wilms Tumor gene which acts as a transcriptional activator or repressor and is essential for proper development of the genitourinary system.
4. LAMB2: this is a gene for laminin, one of the components of the glomerular basement membrane.
5. PLCE1: this surprising gene--which unlike the others does not play an important structural role in the slit diaphragm--encodes an isoform of phospholipase epsilon gene. Individuals with this mutation actually show an increased responsiveness towards steroid therapy.
6. alpha-actinin-4: this gene encodes an actin filament-crosslinking protein which can cause congenital FSGS.
7. TRPC6: this gene encodes a calcium channel expressed in podocytes, and mutations in it can result in congenital FSGS.
This list of genes causing congenital nephrotic syndrome is likely to expand as there are families with this condition which do not link to any of the above loci.
Toluene--a hydrocarbon which is present in gasoline, paint thinners, and many industrial solvents--can have a variety of effects on acid-base metabolism by the kidney: it can cause both a non-anion gap OR an anion gap metabolic acidosis, depending on whether or not the exposure is acute or chronic.
The most well-described with chronic or repeated exposure--as might be seen in a patient who has the unhealthy habit of glue sniffing, or "huffing"--is a renal tubular acidosis, resulting in a non-anion gap metabolic acidosis and hypokalemia. Multiple case reports support the existence of both distal and proximal RTAs with toluene exposure.
However, acute toluene exposure can also lead to an anion gap. This is because the major byproduct of toluene breakdown by the liver's cytochrome p-450 system is hippuric acid, which is an (unmeasured) organic acid.
This is why your 1st-grade teacher told you to stop sniffing the glue.


Since Fall 2010, to better support my yoga practice, I have been doing fall and spring cleanses with the same practitioner. This year, at the prompting of an adventurous yoga friend, I decided to work with a different practitioner. (The buddy system prevails.) To the extent that we are what we eat, I think of this like any other sādhanā, or "practice." It's something that has been worked into the seasonal observances of many traditional cultures. I'm happy to answer any questions you might have about my experience with this sort of practice.
Summer heat and acidity gets trapped in the body, making allergies, joint inflammation and tempers flare. It's important to take time each fall to cool down and clear out your system with a high mineral, super alkalizing, whole foods diet. Sugar is one of the biggest sources of excess acidity in our diets. It can single handedly weaken every system in your body. From premature wrinkles to hypoglycemia and insomnia, from anxiety, loss of focus and mood instability to excess weight and joint pain, sugar is making you who you are, and it's not for the better.
via Online Fall Cleanse and Detox | Charlotte Clews, Yoga and Ayurveda in Maine and Beyond.


his brother's arrow found his throat.
that jam the mailbox while we're away.
Leave us the jigsaw of previous lives.
A waver in the glass.
Heliotrope petals on the river.
He touches her drawings again.
since the bridge-builder buried his bride.
with the flapping of a thousand wings.
Eat slowly. Read what you can by available light.
past scrub and palms to the unyielding sea.
that you thought to find in hard things and fluent.
Our lives are voices in two heads.
The rest is background music.
comes to rest, a blind girl's paperweight.
to the faultless needlework of dream.
We lie embroidered on the mimosa.
Clouds darken the windows, the lamps are lit.
You carry the incense from room to room.
a lamp you lit and forgot to trim.
Raw colours grate against the mind's palette.
The mirror promises only the dark.
smoky lamps afloat on a clouded stream.
Forget the star maps of the Old Kingdom.
our hands can see in the dark.
will find it again, veined and marbled on his tongue.
from the sky's jet branches.
an army of madmen dancing on drowned asphalt.
tattooed it on your skin's acceptance.
we watch it float by on full-moon nights and smile.
The mortgage of our nights and days is so quickly claimed.
to carve a pensive ellipse through space.
never more than half deciphered.
a riddle orbiting in the wide-open eye.
Sickle of the harvest, lantern of our last rooms!
they will pelt you with curses, extradite you to memory.
across a sea that has no walls.
shall we call its cresting blues?
shall we haul it in?
they strike us, the waves.
Born in 1969, Ranjit Hoskote, who writes in English, is a Bombay-based poet, cultural theorist and independent curator of contemporary art. He is the author of ten books, including four collections of poetry, four studies of art and artists, a translation of the poet Vasant Dahake, and an anthology of fourteen contemporary Indian poets. His poems have recently been published in German translation. Hoskote is currently working on a translation of the Kashmiri saint-poet Lal Ded and on his next book of poems.
Copyright ©2006 by Ranjit Hoskote and Green Integer.


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Equity Bancshares, Inc. Will Announce Fourth Quarter 2021 Results on January 26, 2022
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January 14, 2022 16:15 ET | Source: SLR Senior Investment Corp.
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SLR Investment Corp. Schedules the Release of its Financial Results for the Quarter and Fiscal Year Ended December 31, 2021
January 14, 2022 16:15 ET | Source: SLR Investment Corp.
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Safe-T Group Ltd. Receives Nasdaq Notification Regarding Minimum Bid Requirements
January 14, 2022 16:15 ET | Source: Safe-T Group Ltd.
HERZLIYA, Israel, Jan. 14, 2022 (GLOBE NEWSWIRE) -- Safe-T® Group Ltd. (NASDAQ, TASE: SFET), ("Safe-T" or "the Company"), a global provider of cybersecurity and privacy solutions to consumers and...
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CWIN on the move: Relief and Recovery: 2 months Impact
Child Workers in Nepal Concerned Center (CWIN) has kept on working tirelessly for the last two months to reach out to families and children affected by the disastrous earthquake of 25 April 2015 followed by another huge quake of 12 May 2015.
CWIN has, during this period, distributed aid including food supply, tarpaulins, medicines, special child packs and children's recreational packs to more than 15,000 families and more than 75,000 people in all of the 14 most affected districts of Nepal. These districts are Kathmandu, Bhaktapur, Lalitpur, Dhading, Dolakha, Gorkha, Kaski, Kavre, Makwanpur, Nuwakot, Ramechhap, Rasuwa, Sindhuli and Sindhupalchowk. CWIN continues to maintain a strong presence in these communities. CWIN has reached to more than 54,000 children directly in 11 districts with children's packs and recreational packs.
Outreach:
Kathmandu, Bhaktapur, Lalitpur, Dhading, Dolakha, Gorkha, Kaski, Kavre, Makwanpur, Nuwakot, Ramechhap, Rasuwa, Sindhuli and Sindhupalchowk districts.
Relief with Dignity
CWIN distributed family packs containing food supply- rice, lentils, oil, sugar, noodles, beaten rice, soaps, water purifier tablets and other amenities for 15000 families benefitting 75000 people.
Special Child Packs:
CWIN distributed special packs containing toys, stationery, crayons, puzzles, biscuits, toothbrush/toothpaste, powder, nail clippers and Helpline information on child protection to 54000 children in 11 districts.
Tarpaulins/mattresses/blankets:
15800 families received tarpaulins, mattresses and blankets in the initial days of the earthquake.
CWIN will be supporting about 4000 families to build temporary shelters in Dolakha and Dhading districts
Health and Medical Support:
Conducted 25 Health Camps in 11 districts for 6800 children and adults in cooperation with Nepal Pediatric Society (NEPAS) and volunteer doctors from the USA and Germany.
Distributed medicines for 6800 people.
Provided Generator, Water tank, Medicines and clothes to Kanti Children's Hospital.
Distributed relief materials like blankets, food, toys, stationery to injured children admitted in hospitals.
CWIN is also providing support for children with critical illness identified in the health camps for their further treatment and surgery.
CWIN also distributed water purification device with jerry cans to 8 northern VDCs of Dolakha.
Psycho-social Support
Together with NEPAS and Child Health Division of the Ministry of Health, CWIN has produced 200,000 leaflets on promoting psycho-social wellbeing of children in times of disaster to raise awareness among parents and guardians.
CWIN along with Nepal Psychological Institute has established mobile counselling camps in multiple hospitals and temporary shelter camps, to respond to the psycho-social needs of traumatised children.
CWIN has so far trained 87 social workers and counsellors on Psycho-social First Aid (PFA), who are now involved in this initiative with children at different locations within and outside the valleys in districts like Nuwakot, Dolakha, Kaski, Makwanpur and Sindhupalchowk.
CWIN Child Helpline 1098 is also providing telephone counselling to children and young people calling the hotline number.
CWIN Child Helpline 1098 was able to reach out to about 5,000 children through various emergency and humanitarian services to child survivors of the earthquake who are at-risk situations.
In addition Child Helpline 1098 hotline number has received more than 14,000 calls.
Likewise, Helpline was involved in assessing the situation of the earthquake-affected children who are internally displaced and are residing with their families in different parts of Kathmandu. After the assessment, it provided necessary support including education support.
Besides, it has also been involved in rescue and family reintegration of the children who were brought to Kathmandu by suspected traffickers. CWIN is working closely with the Women and Children Service Directorate of Nepal Police to raise awareness of issues related to child protection and to prevent trafficking.
CWIN has started the process to run district child protection desks in Kavre, Sindhupalchwok, and Dolkha districts to protect children from abuse and exploitation. CWIN is running child protection desks through Child Helpline 1098 in Kathmandu, Makwanpur and Kaski districts.
Child-Friendly Spaces
CWIN is also operating 35 Child-Friendly spaces and child protection help desks in Kirtipur, Kathmandu and Dolakha.
Temporary Learning Centres (TLCs)
CWIN is in the process of constructing 160 TLCs in Dolakha, Makwanpur, Sindhupalchok, Kavre and Kathmandu. Some of these are already in operation.
In order to make these TLCs more children friendly, CWIN has distributed 510 recreational packs and school kits in the TLCs.
Nepal Disaster Volunteer Coordination Network
CWIN has initiated a loose network of 14 organisations mobilizing disaster volunteer entitled 'Nepal Disaster Volunteer Coordination Network'.
This network is working to jointly respond to the needs of flood and landslide victims of Taplejung District.
Volunteer Support and solidarity
We have mobilised 850 youth volunteers who selflessly worked with CWIN in delivering relief to children and families this past month. In addition, 400 more local people supported in our relief and recovery work.
Partners/Supporters
CWIN's outreach to the needy children and families was made possible by the generous support and solidarity by its international partners like:
FORUT-Norway
CINI-India
Embassy of India in Nepal
Seljord Folk High School-Norway
CESVI-Italy
ICDI-Netherlands,
Quinoa/Salaai-Belgium,
GRT-Italy,
Peace Boat Disaster Relief Volunteer Center (PBV)
ECPAT Luxembourg
We-world-Italy
Ashmore Foundation
WODEPT Srilanka
United World College South East Asia and well-wishers from different countries.


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Sarah Botstein has been producing award-winning documentaries at Florentine Films since 1997. She recently produced The Vietnam War, co-directed by Ken Burns and Lynn Novick, an immersive, 10-part, 18-hour epic about of one of the most divisive and consequential events in American history. It will air on PBS beginning September 17, 2017. Currently she is also producing a two-part biography of Ernest Hemingway, slated for broadcast in 2020 and a feature length documentary, directed by Lynn Novick, that explores the personal and intellectual transformation of incarcerated men and women in a highly successful prison education program. Ken Burns is the film's executive producer.
Botstein also works on Ken Burns's digital / educational initiatives, and produced and curated the content for the Ken Burns App. The app employs cutting-edge technology and innovative design to highlight themes in American history.


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Oldcastle APG will add lawn and garden operations in Suffolk, Virginia, by renovating a vacant building into new production facility, adding 28 jobs; company also commits to purchase 80% of all forest products from Virginia forest land owners
Sample article from our Household Products
RICHMOND, Virginia , August 16, 2022 (press release) –
Oldcastle APG Lawn & Garden creating 28 new jobs, renovating vacant building into new production facility
Governor Glenn Youngkin today announced that Oldcastle APG, the second largest manufacturer of lawn and garden products in North America, is renovating a vacant building in the City of Suffolk into one of the company's most technologically advanced manufacturing operations. This will be the company's second Lawn & Garden operation in the Commonwealth, alongside Mountain Materials in Russell County, and will lead to major new investment, and the creation of 28 new jobs. The company is also committing to purchase 80 percent of all forest products from Virginia forest land owners. Virginia successfully competed against North Carolina for the project.
"When the nation's leading manufacturers are choosing to locate new facilities in Virginia, it demonstrates the success we are having in reinvigorating job growth and making Virginia an attractive place to do business," said Governor Glenn Youngkin. "I am thrilled this international company is choosing to grow its presence in Virginia and thank them for the new jobs and economic opportunity they are bringing to the City of Suffolk."
"Forestry is Virginia's third largest private industry, bringing an economic impact of more than $21 billion to the Commonwealth each year and supporting more than 108,000 jobs across the state," said Secretary of Agriculture and Forestry Matthew Lohr. "Virginia's loggers, mills and landowners need strong markets for every part of the tree in order to drive our forestry industry forward. That is why I am grateful to Oldcastle APG for this investment and the major new market the facility will create for bark, chips and other co-products from our lumber and paper industries."
"Virginia has long served as an important foothold for our business in the Commonwealth and throughout the entire mid-Atlantic region," said Joe Ertel, President, Oldcastle Lawn & Garden, a division of Oldcastle APG. "We are so appreciative of the opportunities Oldcastle APG has with Virginia and the City of Suffolk to continue growing our business and enhance our outdoor living solutions while mutually benefitting the local community."
"The expansion of Oldcastle Lawn and Garden into Suffolk is an exciting announcement for our city and the economic impact it will have on our community is tremendous," said Mayor Mike Duman. "We are appreciative of the 28 jobs this creates in Suffolk."
"Senate District 14 welcomes Oldcastle APG to the City of Suffolk," said Senator John Cosgrove. "We are grateful for the company's investment in our community and applaud the reuse of an existing structure for its new mulch and garden soils manufacturing facility."
"We are pleased Oldcastle APG chose to locate their newest and most advanced manufacturing operation in the City of Suffolk," said Delegate Clinton Jenkins."Suffolk's central location in Hampton Roads and the overall mid-Atlantic region provides excellent market access for favorable growth in the future and we look forward to celebrating their success."
Headquartered in Atlanta, GA, Oldcastle APG's Lawn & Garden division employs over 1,100 employees across 43 manufacturing sites in the U. S. The company will work with area mills, loggers and tree service businesses to source approximately 80% of its forest product needs from the Commonwealth, which includes Virginia grown logs, bark and pulpwood products over the next three years. The company will convert this material into a variety of premium garden soils, potting mixes and mulches, either bagged for retail sale at major retailers throughout the mid-Atlantic or for bulk sale to commercial landscapers and nurseries.
The Virginia Department of Agriculture and Consumer Services (VDACS) and Virginia Economic Development Partnership worked with the City of Suffolk to secure the project for Virginia. Governor Youngkin approved a $50,000 grant from the Governor's Agriculture and Forestry Industries Development (AFID) Fund, which is administered by VDACS, to win the project for the Commonwealth. The City of Suffolk's Economic Development Authority is matching the AFID award with local funds.
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