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Want to Avoid Type 2 Diabetes? Eat More Whole Grains
It may seem counter intuitive, but eating bread, pasta and cereal may actually help prevent type 2 diabetes, as long as those foods are made from whole grains, new research suggests.
The study found that each serving of whole-grain foods per day was linked to as much as an 11 percent drop in the risk of type 2 diabetes.
"Whole grains appear to play an important role in the prevention of type 2 diabetes, and choosing whole grains over refined grains is highly recommended," said study author Cecilie Kyro. She is a post-doctoral researcher at the Danish Cancer Society Research Center in Copenhagen.
Kyro added that, in addition to preventing type 2 diabetes, there is evidence that whole grains can help prevent heart disease and colon cancer.
More than 30 million Americans have diabetes, and most have type 2 diabetes, according to the American Diabetes Association (ADA). People with type 2 diabetes don't use the hormone insulin efficiently.
Insulin normally ushers blood sugar into cells to be used as energy. But some people are resistant to the effects of insulin, and then more and more insulin is needed to do the same job. Eventually, the insulin-producing cells in the pancreas can't keep up with the demand, and blood sugar levels rise, resulting in type 2 diabetes, according to the ADA.
Lifestyle factors, such as diet and exercise, are known to play a role in type 2 diabetes. In the latest study, researchers wanted to see what role specific whole grains played in type 2 diabetes.
To do this, they reviewed diet information from more than 55,000 people, aged 50 to 65, in Denmark. On average, the group was slightly overweight.
Overall, about 7,400 people were diagnosed with type 2 diabetes during the study's average 15-year follow-up.
The study volunteers completed food diaries. From these food diaries, the researchers calculated how many grams of whole grains each person ate daily.
The investigators found that for every serving of whole-grain food, the risk of type 2 diabetes dropped by 11 percent for men and 7 percent for women.
In women, only wheat and oats seemed to reduce the risk of diabetes. But for men, all whole grains -- wheat, rye and oats -- were linked to a lower risk of the blood sugar disorder. Kyro said this difference may just be a statistical anomaly because fewer women developed diabetes.
She added that all whole-grain products can be recommended for preventing type 2 diabetes in both men and women.
Exactly how whole grains help prevent type 2 diabetes isn't clear from this study. Because it's an observational study, it isn't designed to prove a cause-and-effect relationship.
Still, the scientists suspect that there may be several reasons why whole grains could be protective, including reduced blood sugar secretion after a meal.
Registered dietician Samantha Heller said the findings fall in line with previous research.
"People who consume whole grains have lower risks of type 2 diabetes, as well as inflammation, coronary heart disease and cancer," she said. In addition, a diet including whole grains also helps with weight management and may improve digestive health.
"Whole grains contain fiber, vitamins, minerals, protein and phytonutrients, all of which play important roles in maintaining a healthy body. Dietary fiber decreases insulin resistance, after-meal blood sugar spikes and decreases inflammation, all of which may contribute to its beneficial effects on type 2 diabetes," Heller explained. (Phytonutrients are nutrients from plant sources.)
Kyro said one serving of whole grain contained 16 grams of whole grain. That can vary depending on the type or brand of a product, but 16 grams is approximately one slice of whole-grain bread, she said.
Heller said that U.S. dietary guidelines recommend three to four servings of whole grains a day. A serving is one slice of bread, one-cup of ready-to-eat cereal or 1/2-cup cooked rice, pasta or cereal. She said those recommendations are for people who are sedentary. If you're more active, you may need more grains each day.
Findings from the study were published in the September issue of The Journal of Nutrition.
Labels: tye 2 diabetes, whole grain
New Drug Fingolimod (Gilenya) Could Help Kids With MS
In continuation of my update on Fingolimod
Researchers say the first drug for children with multiple sclerosis vastly outperformed another common MS medication in a new clinical trial.
Fingolimod(Gilenya) reduced relapse rates by 82 percent in patients aged 10 to 17 compared with interferon beta-1a, a drug commonly used to slow the progression of the degenerative nerve disease.
Nearly 86 percent of children on fingolimod remained relapse-free after two years of treatment, compared with only 39 percent of children taking interferon beta-1a, researchers reported.
"I do recommend doctors consider using fingolimod as first-line treatment in pediatric MS," said lead researcher Dr. Tanuja Chitnis, director of the Partners Pediatric MS Center at the Massachusetts General Hospital for Children.
Based on results from this clinical trial, the U.S. Food and Drug Administration in May approved the use of fingolimod in children, Chitnis said.
That makes fingolimod "the first drug approved in the U.S. for pediatric MS," Chitnis said.
Other drugs like interferon beta-1a are used in children, but their use is considered "off-label," said Bruce Bebo, executive vice president of research for the National MS Society.
"We consider this a major development, a major milestone in the MS treatment landscape," Bebo said of fingolimod's approval for use in children.
Multiple sclerosis occurs when the immune system turns on the nervous system and attacks the protective sheath that covers nerve fibers, disrupting communication between the brain and the rest of the body.
MS causes vision problems, numbness or tingling, tremors, slurred speech and fatigue in patients. If left unchecked, it eventually will make it difficult for the person to walk.
Fingolimod is believed to treat MS by suppressing blood levels of lymphocytes, white blood cells that promote the immune system attack on nerve fibers, said Bebo, who was not involved with the trial.
"It slows down dramatically the pathways that lead to relapsing MS," Bebo explained.
The FDA approved fingolimod for use in adults in 2010, and the new trial is part of agency requirements to test new drugs in pediatric patients, Bebo said.
The peak age of MS onset is the 30s and 40s, but about 3 to 5 percent of patients develop symptoms of the disease in childhood, researchers said in background information.
For the clinical trial, 215 young patients were randomly assigned to take either fingolimod, which is an oral drug, or interferon beta-1a, which is injected.
Fingolimod kept MS from progressing in more than 8 out of 10 children taking the drug for two years, more than double the percentage of kids taking interferon beta-1a.
Fingolimod also slowed the development of lesions on the brain and spinal cord, a hallmark of MS. The rate of new or newly enlarged lesions discovered through MRI was 4.4 with fingolimod and 9.3 with interferon beta-1a.
Both drugs carried a high risk of adverse events, 89 percent with fingolimod and 95 percent with interferon beta-1a.
Serious adverse events occurred in about 17 percent of patients taking fingolimod, and included seizures, infection and low white blood cell counts.
"The ultimate decision is based on a clear benefit-risk discussion between the physician and family-patient. A careful review of potential side effects and monitoring is required," Chitnis said.
The findings were published Sept. 12 in the New England Journal of Medicine.
https://en.wikipedia.org/wiki/Fingolimod
Labels: Help Kids With MS, New Drug Fingolimod (Gilenya)
Nocdurna (desmopressin acetate) Approved by FDA as First Sublingual Tablet to Treat Nocturia due to Nocturnal Polyuria
The U.S. Food and Drug Administration (FDA) granted Ferring Pharmaceuticals Inc. approval to market Nocdurna, the first sublingual tablet for the treatment of nocturia due to nocturnal polyuria in adults who awaken at least two times per night to void. The formulation of the sublingual tablet and sex-specific dosing was demonstrated to be effective in reducing nighttime trips to the bathroom in adults 18 years and older.
Nocturnal polyuria, a disease of the kidneys, is the most common underlying cause of nocturia, which can affect adults at every age. It occurs when a person has insufficient nocturnal vasopressin, causing an overproduction of urine in the kidneys at night.2 Unlike treatments that target the bladder or prostate, Nocdurna acts on receptors in the kidney to absorb more fluid and produce less urine during the night while patients sleep. Nocdurna was approved with a boxed warning because it can cause hyponatremia.
"Millions of individuals across the country face nocturia each night, many of whom suffer the daytime consequences of fatigue and lost productivity," stated Jeffrey P. Weiss, MD, FACS, Professor and Chairman of Urology, State University of New York (SUNY) Downstate Medical Center. "Nocdurna offers the first sublingual tablet that can target the source of nighttime urination, the kidney, and effectively reduce the number of times patients have to wake up each night to urinate."
"For more than a decade, Ferring has provided innovative treatments for patients suffering from nocturia in many other countries around the world," said Paul Navarre, CEO, Ferring US. "Following today's FDA approval, we are delighted to make Nocdurna available as an option for US healthcare providers and their patients."
The FDA approval of Nocdurna is based on three double-blind placebo-controlled, multi-center, randomized trials and one open-label extension trial of up to three years in patients 18 years and older. Included in the clinical trials were patients also taking OAB or BPH medications. The co-primary endpoints in studies 1 and 2 were the change in number of nighttime voids compared to baseline, and the percentage of patients who achieved at least a 33% reduction from baseline in the mean number of nighttime voids during three months of treatment. Clinical trials demonstrated an average reduction of nocturnal voids of 52% in women (n=118) and 43% in men (n=102) relative to mean baseline (reduction of 1.5 and 1.3 voids respectively). The mean baseline was 2.9 for women and 3.0 for men. Also, 78% of women and 67% of men receiving NOCDURNA achieved a 33% reduction in mean number of nocturnal voids over a three month period compared to baseline.1
Nocdurna can cause hyponatremia. Severe hyponatremia can be life-threatening, leading to seizures, coma, respiratory arrest, or death. Nocdurna is contraindicated in patients at increased risk of severe hyponatremia, such as patients with excessive fluid intake, illnesses that can cause fluid or electrolyte imbalances, and in those using loop diuretics or systemic or inhaled glucocorticoids. Ensure the serum sodium concentration is normal before starting or resuming Nocdurna. Measure serum sodium within 7 days and approximately 1 month after initiating therapy, and periodically during treatment. Monitor serum sodium levels more frequently in patients 65 years of age and older and in patients at increased risk of hyponatremia. If hyponatremia occurs, Nocdurna may need to be temporarily or permanently discontinued.
Labels: First Sublingual Tablet, Nocdurna (desmopressin acetate) FD, Treat Nocturia due to Nocturnal Polyuria
Research does not confirm antidiabetic action of natural fatty acid derivatives
A research consortium between the healthcare company Sanofi and Johannes Gutenberg University Mainz (JGU) investigated the antidiabetic action of certain natural fatty acids, so-called FAHFAs, which US-American scientists had reported in 2014. For some of these compounds, e.g. 5-PAHSA and 9-PAHSA, elevated levels were found in mice which overexpressed the glucose transporter Glut4. This transporter is controlled by insulin and causes the uptake of blood glucose in particular into muscle cells. It had been reported that both PAHSA isomers occur in food and are also produced by human cells. Diabetics have lower blood levels of these compounds than healthy individuals. When mice were fed with a FAHFA-enriched diet, their blood glucose levels were found to decrease and insulin was released.
These results published in a prominent journal caused a stir among scientists as they suggested a new point of attack in the fight against a widespread disease. Chemists under guidance of Professor Till Opatz from Mainz University synthesized the stereoisomers of 5- and 9-PAHSA and sent them to their colleagues at Sanofi in Frankfurt for biological testing. In some of the tests, rudimentary metabolic changes could be detected but the overall effect of the compounds was sobering: none of these molecules was able to achieve positive effects on clearly defined endpoints in metabolism.
The results of the researchers from Frankfurt and Mainz recently appeared in Cell Metabolism, a highly renowned international scientific journal. Now the German scientists hope for a constructive discussion on the discrepancy between both studies resulting in a better understanding of the disease models.
The current publication demonstrates the successful collaboration between a university and a research-active healthcare company in a highly relevant area of basic research in biomedicine. It underlines the importance of verification of scientific results and their disclosure.
Labels: antidiabetic action, natural fatty acid derivatives, No confirmation
Lenabasum has acceptable safety and tolerability in diffuse cutaneous systemic sclerosis
The results of an open label extension of a phase II study presented today at the Annual European Congress of Rheumatology (EULAR 2018) demonstrate that lenabasum ontinues to have acceptable safety and tolerability in diffuse cutaneous systemic sclerosis (dcSSc) with no severe or serious adverse events (AE).
"There is a critical unmet need for safe and effective therapeutics for patients with dcSSc," said Professor Thomas Dörner, Chairperson of the Abstract Selection Committee, EULAR. "These results demonstrate a significant step forward in the clinical development of a potentially impactful treatment for people suffering with this devastating disease."
Systemic sclerosis is a rare but serious autoimmune disease which causes hardening and swelling of the skin, as well as joint pain, digestive problems, lung disease, and sometimes problems with the heart and kidneys. The disease occurs in around 30 people per million population per year. The diffuse cutaneous subtype (dcSSc) is even rarer, affecting just one in every four people with the disease. It is linked with early damage to internal organs, as well as painful skin thickening that quickly gets worse. Only half of people diagnosed with dcSSc will survive for 10 years or more.
Medicines for dcSSc are very limited, immunosuppressants are sometimes used although there have been relatively few trials in dcSSc patients specifically because the disease is so rare and difficult to research.
"Our results are very encouraging and reinforce the positive findings from the double-blinded placebo-controlled part of the study with regard to safety and tolerability," said Robert Spiera, M.D., Director of the Scleroderma and Vasculitis Program at Hospital for Special Surgery, Weill Cornell Medical College in New York City and principal investigator. "We look forward to continuing our investigations to assess the role of lenabasum as a new treatment option for patients with dcSSC."
Lenabasum (JBT-101) is a selective cannabinoid receptor type 2 agonist that activates resolution of innate immune response in humans and reduces inflammation and fibrosis in animal models of SSc. It is a synthetic, oral, non-immunosuppressive small molecule.
The results of the initial phase II trial demonstrated that lenabasum had acceptable safety and tolerability in dcSSc and demonstrated consistent evidence of clinical benefit. In addition, changes in gene expression were shown to be consistent with biologic effects of lenabasum on pathways relevant to SSc.
Thirty-six patients, who completed the phase II trial, enrolled into the one year open-label extension (OLE) to receive lenabasum 20mg twice a day. Results suggested improvement in multiple efficacy outcomes measured both from the start of the original study and the OLE. In the 25 subjects who completed a year in the OLE, the mean improvements from the study start included an improvement in ACR CRISS score* by 56%. There was also a reduction in modified Rodnan Skin Score, HAQ-DI†, Physician Global Assessment, and 5-D Itch Questionnaire by 8.6, 0.14, 0.9, and 2.3 respectively. Forced vital capacity percentage predicted was stable from study start with mean change of 0.4%.
The mean duration of treatment in the OLE was 45 weeks with 19 patients completing 60 weeks of treatment. Three subjects discontinued the trial, two due to AEs and one withdrew consent. AEs occurred in 33/36 subjects in the OLE, however only seven had AEs related to lenabasum (none of which were severe). In total, one subject had an AE considered life threatening, three severe, 21 moderate, and eight mild. One subject developed renal crisis involving two severe and one life-threatening/serious AE (deemed unrelated to lenabasum). Most common AEs across all subjects were upper respiratory tract infection (22%), urinary tract infection (14%), diarrhea (11%), skin ulcers (11%), and mild intermediate dizziness (8%).
An international phase III clinical trial of lenabasum has been initiated with results expected in the first half of 2020.
Labels: acceptable safety and tolerability, diffuse cutaneous systemic sclerosis, Lenabasum
Drug used to treat myelofibrosis can awaken 'dormant' lymphomas in the bone marrow
"Using bone marrow biopsies taken right at the start of the disease, we were able to show that primordia of lymphoma were present in the form of a B-cell clone," explain Heinz Gisslinger and Ulrich Jäger from the Division of Hematology/Hemostatsology of MedUni Vienna's Department of Medicine I. 16% of myelofibrosis patients were found to have dormant aggressive lymphoma. In approximately 6% of these patients, it then erupts when stimulated by the administration of JAK2 inhibitors.
According to the hematologist, it is possible to detect dormant lymphomas, if they are actively sought using sensitive, molecular biological techniques. "This is therefore the best predictive tool. It enables us to filter out the relevant 16%, categorize them and identify them as high-risk patients prior to treatment with JAK2 inhibitors."
The findings of the hematologists working with MedUni Vienna's Division of Medical-Chemical Laboratory Diagnostics and Clinical Pathology were substantiated by researchers at Vetmeduni Vienna, led by Veronika Sexl. They demonstrated in a mouse model that mice who have had bone marrow transplants likewise developed lymphomas. Says Jäger: "The findings from Vetmeduni Vienna fitted together with ours like a piece of a jigsaw puzzle." Moreover, two individual cases from Paris, from international collaborative partner Hôpital Saint-Louis, backed up the conclusions of the Vienna study, which has now been published in the prestigious journal "Blood", where it was also featured in the editorial.
"This multilateral collaboration is a perfect example of how open the research landscape has generally become and how important the reciprocal exchange of data is in medicine," says Jäger. This is also the direction taken by the next step of this project: a start is already being made on collecting international cases and associated data, in order to further enhance drug safety, and researchers are working closely with the pharmaceutical companies who produce these standard drugs. "Our findings represent a paradigm shift and improve the safety of this class of drugs," emphasize Sexl and Jäger.
"I am delighted by the quick, efficient and groundbreaking bridge between the mouse model and the clinical findings that we have succeeded in forming in this case. The basic research, preclinical and clinical work have all fitted together perfectly," adds Sexl.
Ref : https://www.meduniwien.ac.at/web/en/about-us/news/detailsite/2018/news-im-juni-2018/standard-myelofibrosis-drug-can-awaken-dormant-lymphoma/
Labels: awaken 'dormant' lymphomas, bone marrow, Drug for myelofibrosis
Eating plant-based diet can reduce risk for heart problems in people with type 2 diabetes
Plant-based diets improve glycemic control, lead to weight loss, and improve cholesterol in people with type 2 diabetes, according to a new review published in the journal Clinical Nutrition.
Researchers reviewed nine randomized controlled trials that assessed the effectiveness of vegan and vegetarian diets for diabetes patients. The results show that those who ate a plant-based diet lowered their cholesterol, lost weight, lowered HbA1c levels, and improved other cardiometabolic risk factors when compared to those who ate a nonvegetarian diet.
More than 100 million Americans currently have diabetes or prediabetes. Those with diabetes are two to four times more likely to die from cardiovascular disease than those who do not have diabetes.
"The link between diabetes and cardiovascular disease is strong. Sixty to seventy percent of people who have type 2 diabetes die of heart disease," says study co-author Hana Kahleova, M.D., Ph.D., director of clinical research at the Physicians Committee for Responsible Medicine. "The good news is that this study shows that the same simple prescription--eating a plant-based diet--can reduce our risk for heart problems and improve type 2 diabetes at the same time."
The study authors suggest that plant-based diets, which center on fruits, vegetables, grains, and legumes, benefit both glycemic control and cardiovascular health, because they are low in saturated fat, rich in phytochemicals, high in fiber, and often rich in low-glycemic fruits and vegetables.
Previous controlled trials and prospective cohort studies have shown that a plant-based dietary pattern is associated with a lower risk of coronary heart disease, type 2 diabetes, obesity, hypertension, cardiovascular mortality, and all-cause mortality.
Ref : https://www.elsevier.com/books/vegetarian-and-plant-based-diets-in-health-and-disease-prevention/mariotti/978-0-12-803968-7#
Labels: Eating plant-based diet, reduce, risk for heart problems, type 2 diabetes
FDA Approves Mircera for Anemia Associated with Chronic Kidney Disease in Pediatric Patients on Dialysis
Food and Drug Administration approved methoxy polyethylene glycol-epoetin beta (Mircera, Vifor Pharma Inc.) for the treatment of pediatric patients 5 to 17 years of age on hemodialysis who are converting from another ESA after their hemoglobin level was stabilized with an ESA.
Approval was based on data from an open-label, multiple dose, multicenter, dose-finding trial (NCT00717366) in 64 pediatric patients (ages 5 to 17 years) with CKD on hemodialysis and had stable hemoglobin (Hb) levels while previously receiving another ESA (epoetin alfa/beta or darbepoetin alfa). Patients were administered Mircera intravenously once every 4 weeks for 20 weeks. After the first administration of Mircera, dosage adjustments were permitted to maintain target Hb levels.
Efficacy was based on maintaining Hb levels within target levels in the above clinical trial, and also from extrapolation from trials of Mircera in adult patients with CKD. The safety findings observed in pediatric patients were consistent with those previously reported in adults.
For conversion from another ESA, Mircera is dosed intravenously once every 4 weeks based on total weekly epoetin alfa or darbepoetin alfa dose at time of conversion. Full prescribing information is available at Mircera PI.
Labels: Mircera for Anemia Associated with Chronic Kidney Disease, Pediatric Patients on Dialysis
FDA approves combination of Venclexta and Rituxan for lymphocytic leukemia treatment
Venclexta® (venetoclax) Rituxan® (rituximab)
In continuation of my update on Venclexta® (venetoclax) and Rituxan® (rituximab)
Genentech, a member of the Roche Group, announced today that the U.S. Food and Drug Administration (FDA) has approved Venclexta® (venetoclax) in combination with Rituxan® (rituximab) for the treatment of people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), with or without 17p deletion, who have received at least one prior therapy. Venclexta is being developed by AbbVie and Genentech, a member of the Roche Group. It is jointly commercialized by the companies in the United States and commercialized by AbbVie outside of the United States.
"We are pleased that this approval makes Venclexta, a first of its kind targeted therapy, available for more people with chronic lymphocytic leukemia whose disease has returned after previous treatment," said Sandra Horning, M.D., chief medical officer and head of Global Product Development. "Venclexta plus Rituxan provides a new chemotherapy-free option shown to help people live longer without their disease progressing compared to a standard-of-care therapy."
The approval of Venclexta plus Rituxan for people with previously treated CLL is primarily based on the results of the Phase III MURANO study, which were published online in the New England Journal of Medicine in March 2018 and presented at the American Society of Hematology Annual Meeting in December 2017. The results showed that a fixed duration of treatment with Venclexta plus Rituxan significantly reduced the risk of disease progression or death (progression-free survival; PFS) by 81 percent compared with bendamustine plus Rituxan, a current standard of care (HR=0.19; 95 percent CI 0.13-0.28; p<0.0001).
The most common side effects of Venclexta in combination with Rituxan include low white blood cell count, diarrhea, upper respiratory tract infection, cough, fatigue and nausea.
Today's FDA approval converts Venclexta's accelerated approval to a full approval. The FDA has also updated the indication for Venclexta as a single agent, which is now approved for the treatment of people with CLL or SLL, with or without 17p deletion, who have received at least one prior therapy. Venclexta was previously granted accelerated approval in April 2016 as a single agent for the treatment of people with CLL with 17p deletion, as detected by an FDA approved test, who have received at least one prior therapy.
The supplemental New Drug Application (sNDA) based on the MURANO data was granted Priority Review, a designation given to medicines that the FDA has determined to have the potential to provide significant improvements in the treatment, prevention or diagnosis of a disease. The FDA also previously granted Breakthrough Therapy Designation for Venclexta in combination with Rituxan for the treatment of relapsed or refractory CLL. Venclexta in combination with Rituxan is recommended in the National Comprehensive Cancer Network (NCCN) guidelines as a treatment option for previously treated CLL (Category 1, Preferred).
An application for a variation of the marketing authorization based on the MURANO data has also been submitted to and validated by the European Medicines Agency (EMA). Additional submissions of the MURANO data to health authorities around the world are ongoing.
https://www.gene.com/media/press-releases/14728/2018-06-08/genentech-announces-fda-approval-for-ven
Labels: combination of Venclexta and Rituxan for lymphocytic leukemia treatment
Infant Omega-3 Supplementation Tied to Decreased Waist Size
In continuation of my update on Omega-3 fatty acids
Omega-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) supplementation in infancy is associated with reduced insulin concentrations and insulin resistance in boys and reduced waist circumference in both sexes at age 5 years, according to a study published online June8 in Pediatrics.
Valene H.L. See, Ph.D., from the Royal Perth Hospital in Australia, and colleagues randomly assigned 420 infants to a daily supplement of n-3 LCPUFA or olive oil (control) from birth to 6 months. Growth, body composition, and cardiometabolic risk factors were evaluated at 5 years of age.
The researchers found that infants who received n-3 LCPUFA had a smaller waist circumference at 5 years (coefficient, 1.1 cm), which remained significant after adjusting for confounders (coefficient, 0.8 cm). Boys who received n-3 LCPUFA supplementation had a 21 percent reduction in insulin concentrations and a 22 percent reduction in insulin resistance versus the control group. At birth, 2.5 years, and 5 years, there were no other differences in growth and cardiometabolic risk factors between the groups.
"Longer-term follow-up of the cohort is warranted to determine whether these differences are maintained into adolescence," write the authors
Labels: Omega-3 Supplementation Tied to Decreased Waist Size
Infant Omega-3 Supplementation Tied to Decreased Waist Size..
Labels: Decreased Waist Size, Omega-3 Supplementation
Topical Rapamycin Effective for TSC-Related Facial Angiofibromas
In continuation of my update on Rapamycin
Topical rapamycin seems effective for tuberous sclerosis complex (TSC)-related facial angiofibromas, according to a study published online May 23 in JAMA Dermatology.
Mary Kay Koenig, M.D., from The University of Texas Health Science Center at Houston, and colleagues examined the efficacy and safety of topical rapamycin for TSC-related facial angiofibromas in a study involving 179 patients. Participants were randomized in a 1:1:1 ratio to topical formulation containing 1 percent rapamycin, 0.1 percent rapamycin, or vehicle alone (59, 63, and 57 patients, respectively). The formulation was applied daily to designated areas at bedtime.
The researchers observed clinically meaningful and statistically significant improvement in facial angiofibromas for 1 and 0.1 percent rapamycin versus vehicle only, and for 1 versus 0.1 percent rapamycin; most of the improvement was seen in the first month. The Angiofibroma Grading Scale mean improvement at six months was 16.7, 11.0, and 2.1 points for 1 and 0.1 percent rapamycin and vehicle only, respectively (P < 0.001 for 1 and 0.1 percent versus vehicle only). End-of-treatment photos were rated better than baseline for 81.8, 65.5, and 25.5 percent of patients in the 1 and 0.1 percent rapamycin groups and the vehicle group, respectively (P < 0.001 for all three pairwise comparisons).
"Topical rapamycin appears effective and safe for treatment of TSC-related facial angiofibromas," the authors write. "In this trial, the preferred dose was 1 percent once daily."
Several authors disclosed financial ties to Novartis; one author disclosed ties to MedStudy. Several authors have a provisional patent pending
Ref : https://jamanetwork.com/journals/jamadermatology/article-abstract/2682034?resultClick=1
Labels: Rapamycin Effective, TSC-Related Facial Angiofibromas
Eating raspberries improves function of cells lining blood vessels, research shows
In continuation of my update on Raspberry
New research led by Dr Ana Rodriguez-Mateos, School of Life Course Sciences, shows that eating red raspberries improves the function of the cells that line blood vessels.
Endothelial cells form the interior lining of our blood and lymphatic vessels. They act as a barrier between the blood or lymph and the surrounding body tissue as well as playing key roles in blood clotting and regulating blood pressure amongst other things. Sometimes these cells stop working efficiently (called endothelial dysfunction) which is thought to be a significant factor in the development of cardiovascular disease.
Dr Rodriguez-Mateos and her colleagues studied ten, healthy male volunteers aged 18-35 years. Participants were randomly given drinks containing no, 200g or 400g of raspberries. Researchers monitored chemicals in their blood and urine as well as their blood pressure and flow-mediated dilation (FMD) of the brachial artery: a measure of how the artery widens when blood flow increases.
The results showed a significant increase in FMD for participants that drank raspberry-containing drinks. The effect lasted for at least 24 hours and there was also a correlating increase in the levels of urolithin metabolites found in their blood. These are produced by bacteria in the gut as ellagitannins, a chemical found in raspberries, are digested. Researchers believe that ellagitannins could therefore be beneficial to vascular health.
If the change in FMD seen could be sustained for long enough, it would reduce a person's risk of developing cardiovascular disease by up to 15%. Further studies are needed to establish whether these results translate into long-term health benefits in the general population and whether red raspberries and other foods rich in ellagitannins (such as strawberries, pomegranate or nuts) should be included as part of a healthy diet to help prevent cardiovascular disease.
Speaking of the findings Dr Rodriguez-Mateos said:
'Although more studies are needed to confirm our findings, we are very excited about the potential role of raspberries and ellagitannins in cardiovascular disease prevention. Following up on this study, we are now investigating the long-term benefits of ellagitannins in a larger group of healthy individuals and we are also looking at how our gut microbiota may have an impact on their health benefits.
More : https://www.kcl.ac.uk/lsm/schools/life-course-sciences/news-events/newsrecords/2018/could-eating-raspberries-prevent-cardiovascular-disease.aspx
Labels: blood vessels, improves function of cells, Raspberry, research shows
Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1
Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced new positive results from its Phase 1/2 study with lumasiran, an investigational RNAi therapeutic targeting glycolate oxidase (GO) for the treatment of Primary Hyperoxaluria Type 1 (PH1). Results were presented at the OxalEurope, European Hyperoxaluria Consortium, taking place on June 8, 2018 in Naples, Italy.
Updated interim data were from Part B of the Phase 1/2 study and were as of the data cut-off date of March 29, 2018. Part B is a randomized (3:1 drug:placebo), single-blind, placebo-controlled evaluation of lumasiran in patients with PH1. Cohorts 1 and 2 received three monthly doses of lumasiran at 1 mg/kg or 3 mg/kg, respectively; Cohort 3 received two quarterly doses at 3 mg/kg. An additional eight patients received open-label lumasiran in expansions of each of the first two cohorts, totaling 20 patients enrolled. Patients randomized to the placebo group also received subsequent subcutaneous administration of lumasiran following administration of placebo. Patients had a mean age of 14.9 years (range: 6-43) and a mean estimated glomerular filtration rate (eGFR) of 77 mL/min/1.73m2 (range: 42-131).
Lumasiran demonstrated a mean maximal reduction in urinary oxalate of 64 percent in patients enrolled in Cohorts 1-3 (N=12). All lumasiran-treated patients experienced a lowering in urinary oxalate below 0.7 mmol/24 hrs/1.73m2, a threshold level associated with a reduced rate of progression to end-stage renal disease. On day 85, patients receiving lumasiran (N=9) maintained a mean reduction in urinary oxalate of 63 percent (range: 49-73 percent). Alnylam believes the potent and durable reductions in urinary oxalate support a once quarterly, subcutaneous dose regimen. Further, these results continue to support the hypothesis that GO inhibition has the potential to reduce and possibly normalize levels of hepatic oxalate production, thus potentially halting PH1 disease progression. Dosing in Part B of the Phase 1/2 study is ongoing and eligible patients are transitioning into an open-label extension (OLE) study. The Company expects to present additional data from all cohorts as well as from the OLE study in late 2018.
"We are pleased to present data that signal hope to patients with PH1, an ultra-rare, life-threatening disease, with a profound unmet need. Given the encouraging results, we believe that lumasiran has the potential to alleviate the pathologic overproduction of oxalate, the metabolite that causes the severe, systemic manifestations of PH1. Furthermore, we believe these results validate our approach of targeting GO, a key liver enzyme involved in the excessive oxalate output in patients with PH1," said Pritesh J. Gandhi, PharmD., Vice President and General Manager, Lumasiran program at Alnylam. "Based upon our recent discussions with the FDA, we are on track to advance this program into Phase 3 development at mid-year, with the goal of bringing lumasiran to patients around the world as rapidly as possible."
"PH1 is an ultra-orphan disease, with a generally pediatric onset and an immediate need for an effective intervention. Today, patients with advanced disease have no choice but to undergo intensive dialysis and, ultimately, a dual liver/kidney transplant, with no other approved treatment alternatives in place," said Prof. Bernd Hoppe, M.D., Head of the Division of Pediatric Nephrology, Department of Pediatrics, University of Bonn, Germany and an investigator in the lumasiran study. "The data presented on lumasiran provide evidence for oxalate reduction, highlighting the potential of this investigational medicine as an innovative approach for the treatment of patients with PH1."
Lumasiran was generally well tolerated in all patients in the Phase 1/2 study (N=20). Fifteen (75 percent) of patients treated with lumasiran experienced an adverse event (AE); the majority of AEs were mild or moderate in severity and unrelated to study drug. AEs occurring in three or more patients included abdominal pain, headache, nasopharyngitis, pyrexia, and vomiting. Two patients reported injection site reactions, both of which were mild and transient. Two patients reported severe AEs; one patient had pyelonephritis during placebo dosing and one patient had a kidney stone with renal colic after lumasiran dosing. One patient receiving placebo and three patients receiving lumasiran reported serious adverse events (SAEs); none were assessed as related to study drug. The placebo patient experienced kidney stones and pyelonephritis. The lumasiran patients with SAEs included one patient with kidney stones, one patient with fever and abdominal pain, and one patient with gastroenteritis. Lumasiran has not been associated with any clinically significant adverse laboratory findings, and there were no study discontinuations due to AEs through the data cut-off date.
Alnylam recently announced alignment with the U.S. Food and Drug Administration (FDA) on a pivotal study design for lumasiran, including a primary endpoint at six months based on reduction of urinary oxalate, and a study size of approximately 25 patients with PH1. The Company has guided its intention to initiate the Phase 3 trial in mid-2018. Lumasiran has received Breakthrough Therapy Designation from the FDA and Priority Medicines (PRIME) designation from the European Medicines Agency (EMA).
Ref : http://investors.alnylam.com/news-releases/news-release-details/alnylam-reports-updated-positive-results-phase-12-study
Labels: Phase 1/2 study of lumasiran in patients with PH1
New approach to kill specific bacteria could be alternative to antibiotics
A new approach to killing C. difficile that silences key bacterial genes while sparing other bacteria may provide a new way to treat the most common hospital-acquired bacterial infection in the United States, according to researchers.
While conventional antibiotics treat bacterial infections, they can also cause a condition in the colon called C. difficile infection, due to the drug killing both good and bad bacteria in the gut.
In a lab, researchers created three new antibiotics that kill C. difficile by preventing the expression of bacterial genes that are important for its survival. This approach -- called antisense therapy -- allows the drug to kill only C. difficile, unlike many antibiotics that kill multiple forms of bacteria.
"We were able to show that these drugs can zero in on and kill C. difficile bacteria while leaving other bacteria alone," said Arun Sharma, associate professor of pharmacology, Penn State College of Medicine. "We're still working to refine these drugs and make them even better, with the eventual goal of testing them clinically."
David Stewart, an associate professor of surgery at the University of Arizona who along with Sharma is a co-principal investigator on this study, said the drug works in a completely different manner than the antibiotics currently used.
"These drugs are organism specific, meaning that they target only one kind of bacteria, kind of like smart antibiotics," Stewart said. "They're precise. And that's especially important with C. difficile infections because this bacteria is uniquely, selectively advantaged to exploit ecological disturbances in the human gut."
While C. difficile is normally present in the gut, other "good" bacteria are also present, and all these bacteria contribute to a person's microbiome. When a person's microbiome is healthy and balanced, it keeps bad bacteria like C. difficile under control.
But if a patient takes an antibiotic for another condition, the antibiotic kills many different types of bacteria, including the good ones keeping C. difficile under control. This allows C. difficile to thrive, causing an infection that can result in severe gastrointestinal symptoms. Since antibiotics can contribute to C. difficile infections, the researchers said a new, alternative treatment for these infections is desirable.
"Ideally, a treatment for C. difficile would have no effect on other bacteria," Stewart said.
The researchers, who recently published their findings in the Journal of Antibiotics, said that while most antibiotics lack organismal specificity -- the ability to target just one type of organism -- antisense treatments show great potential for being able to target only specific bacteria.
"Our antisense antibiotics contain genetic material which is complementary to bacterial genetic material, so we designed our genetic material to target specific genes in C. difficile," Stewart said. "And when our genetic material binds to the bacterial genetic material, it prevents the expression of bacterial genes. And that can cause C. difficile to die."
The drug tested in the study consisted of two components: the antisense compound that targeted the genetic material in C. difficile -- referred to as an antisense oligonucleotide (ASO) -- and a carrier compound that transported the ASO into the bacteria, referred to by the research team as a CAB. The researchers tested three versions of the drug, each with a different version of CAB.
The researchers tested each compound to see how much of the drug was required to kill C. difficile bacteria, whether it was toxic or not to human colon cells, and whether it also harmed other bacteria normally found in the gut -- like E. coli.
"Ultimately, we wanted these compounds to deliver the drug into the C. difficile bacteria without hurting other bacteria or the patient," Sharma said. "After testing these three, we found that one carrier in particular -- CYDE-21 -- was the best at delivering an effective dose of the drug into the bacteria."
In the future, the researchers said they will conduct further studies to continue to refine the carriers to increase their capacity and minimize their effect on other bacteria and human cells.
"In this study, as a first effort, the carrier is pretty good, and we'd like to do even better," Stewart said. "It has minimal antibacterial activity, minimal toxicity and it's an effective carrier of our cargo. So what we're working on now is modifying our carriers for future testing in preparation for animal studies."
Ref : https://www.nature.com/articles/s41429-018-0056-9
Labels: alternative to antibiotics, C. difficile, kill specific bacteria
Two-drug combination provides more reliable, effective care for women suffering miscarriage
In continuation of my update on mifepristone
A combination of the drugs mifepristone and misoprostol can help bring closure to some women and their families suffering from miscarriage, and reduces the need for surgical intervention to complete the painful miscarriage process. Results of a new clinical trial led by researchers at the Perelman School of Medicine at the University of Pennsylvania, show that while the standard drug regimen using misoprostol on its own frequently fails to complete the miscarriage, a combination of misoprostol and the drug mifepristone works much more reliably. The report is published today in the New England Journal of Medicine.
mifepristone misoprostol
Each year in the United States alone approximately 1 million women have miscarriages. When the body does not expel the pregnancy tissue on its own – the final part of a miscarriage – women need to undergo a surgical procedure or take the drug misoprostol. Though often preferable for its convenience and privacy – patients can take it in the comfort of their own homes – misoprostol does not always work, and many women who use misoprostol are still left with no option but to undergo an invasive procedure they wished to avoid, prolonging an already physically and emotionally difficult situation.
"Though rarely discussed openly, miscarriage is the most common complication of pregnancy, and the public health burden is both physical and psychological. For too many women, misoprostol alone just leads to frustration. I have seen my patients suffer from the insult of the treatment failure added to the injury of the initial loss," said study lead author Courtney A. Schreiber, MD, MPH, chief of the division of Family Planning and an associate professor of Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania. "As physicians, we have to do better for these patients, and our new study shows that by combining mifepristone with misoprostol, we can."
Mifepristone is used along with misoprostol to induce abortion in early pregnancy. But the effectiveness of mifepristone-misoprostol for miscarriage patients, in comparison to the commonly used misoprostol alone, has been unclear.
In the new study, 300 women who had been diagnosed with early pregnancy loss – described as a miscarriage in the first trimester – were assigned to receive the standard 800 micrograms of misoprostol placed vaginally. Half were also randomly assigned to receive pretreatment with a 200 mg pill of mifepristone, which primes the uterus to respond to misoprostol's contraction-inducing effect.
The researchers found that overall, 91.2 percent of women receiving the mifepristone pretreatment plus misoprostol experienced gestational sac expulsion -; the definition of a completed miscarriage -; 83.8 percent by their first follow-up visit, which occurred two days after the treatment on average. Misoprostol alone was only effective 75.8 percent of the time, with 67.1 percent completing by their first follow up visit.
The researchers looked at a variety of outcomes in the study, and essentially all were better for the women taking mifepristone plus misoprostol. Patients assigned to this group, for example, had a much lower chance (8.8 percent) of needing a surgical intervention by day 30, compared to 23.5 percent for the misoprostol-alone group. There were no significant differences between the groups in terms of pain, bleeding, or other side-effects. Notably, serious side effects were rare in both groups.
Mifepristone is a highly regulated medication. At present, the U.S. Food and Drug Administration requires that the drug be dispensed only in registered hospitals, clinics and doctor's offices, but not in retail pharmacies. Schreiber says that physicians who wish to treat women with miscarriages – including but not limited to physicians in obstetrics, internal medicine, emergency medicine, and family medicine – should consider registration.
"High-quality care for women who suffer miscarriage not only improves physical outcomes, but helps alleviate the psychosocial stress that can accompany the loss of a pregnancy," she says. "Given how common miscarriage is and the effectiveness of the drug combination as shown in this new study, any doctor who cares for women who become pregnant, and therefore could have a miscarriage, should be registered to prescribe and dispense mifepristone."
Ref : https://www.pennmedicine.org/news/news-releases/2018/june/drug-combination-offers-more-effective-care-for-patients-suffering-miscarriage-penn-study-shows
Labels: effective care for women suffering miscarriage, mifepristone and misoprostol, Two-drug combination providesreliable
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Home ▸ Fred Schneider – Net Worth, Age, Wikipedia, Family, Biography
Fred Schneider – Net Worth, Age, Wikipedia, Family, Biography
Fred Schneider Wiki Biography
Fred Schneider Net Worth $5 Million
Born Frederick William Schneider III on the 1st July 1951 in Newark, New Jersey USA, Fred is a singer-songwriter best known to the world as the founding member of the new wave group The B-52's in the mid-1970s.
Have you ever wondered how rich Fred Schneider is, as of mid- 2017? According to authoritative sources, it has been estimated that Schneider's net worth is as high as $5 million, an amount earned through his successful career in the entertainment industry. Apart from The B-52's, Fred has collaborated with numerous other musicians, including Richard Barone, Joe McIntyre, Elvira, among many others, which has also improved his wealth.
Fred's love of music didn't emerge until later in his life. In the early days he listened to Halloween songs, nutty Christmas songs and Motown recordings. Gradually he became more interested in music, but his studies hindered him from pursuing a career in music – he graduated from the University of Georgia, and despite his growing interest in music, Fred wasn't involved in the music scene until the formation of The B-52's; prior to that, he worked as a janitor. and driver for Meals on Wheels.
The group was created in a strange way; Ricky Wilson, Keith Strickland, Cindy Wilson and Kate Pierson, alongside Fred were all together at a Chinese restaurant located in Athens, Georgia; they started singing without even planning it, and after the night ended they decided to form a band. They had several different names in circulation, but decided on The B-52's which is a tribute to a particular beehive hairdo resembling the nose cone of the aircraft of the same name.
Their first self-titled album came out in 1979, which reached No. 59 on the US Billboard 200 chart, and achieved platinum status, which certainly increased Fred's net worth, and encouraged him and the rest of the group to continue to perform together. However, they couldn't make a breakthrough, always being overshadowed by other similar acts of the era. Things became worse in 1985 when Ricky Wilson died of AIDS. He kept his illness from other band member from when he was diagnosed in 1983, except from Strickland. After his death, Cindy Wilson, who is his sister, fell into deep depression, and the group made an official statement of their hiatus.
They reformed in 1989 and since then have released three albums, including their highest charting "Cosmic Thing" (1989), which reached No. 4 on the US Billboard 200 chart, and achieved multiple platinum status in the US and Australia, which only increased further Fred's net worth.
Their last studio release "Funplex", came out in 2008, but to mediocre success. Since then they have been touring constantly, but haven't released any new material.
Fred has also released two albums on his own – "Fred Schneider and the Shake Society" originally released in 1984, but re-released in 1991, and "Just Fred" (1996), the sales of which also added to his net worth.
To speak further of his accomplishments, Fred has started the group The Superions, which released one studio album "Destination… Christmas" (2010), and a number of singles with two EPs as well, "The Superions" (2010), and "Batbaby" (2011).
Regarding his personal life, Fred is openly gay, and has spoken about his coming out to his mother in an interview with Howard Stern. Fred is a vegetarian, and has volunteered with PETA in several campaigns, including the one discouraging people from eating lobsters!
Full Name Fred Schneider
Date Of Birth July 1, 1951
Place Of Birth Newark, New Jersey, United States
Profession Singer-songwriter
Education University of Georgia
Allmusic http://www.allmusic.com/artist/fred-schneider-mn0000174155
Awards IEEE Emanuel R. Piore Award
Music Groups The B-52's, The Superions
Movies The B-52's Time Capsule: Videos for a Future Generation, The Rugrats Movie, The Groovenians, Godass
1 We just did our own thing, which was a combination of rock 'n 'roll, funk, and Fellini, and game show host, and corn, and mysticism. (Recalling how The B-52's got their distinctive sound.)
1 Recording The B-52's forthcoming album, due out in autumn of 2006. [2005]
2 Frequently touring with The B-52's. [2005]
3 Member of The B-52's.
Kim's Convenience 2016 TV Series writer – 1 episode
The Tonight Show Starring Jimmy Fallon 2015-2016 TV Series writer – 2 episodes
Britain's Got Talent 2016 TV Series writer – 1 episode
Best Time Ever with Neil Patrick Harris 2015 TV Series writer – 1 episode
The Muppets. 2015 TV Series writer – 1 episode
Seriesly 2015 TV Series 1 episode
Man Up 2015/I writer: "Love Shack" – as Frederick Schneider
Late Night with Seth Meyers 2015 TV Series music – 1 episode
Glee 2012-2015 TV Series writer – 2 episodes
Strictly Come Dancing 2014 TV Series writer – 1 episode
Tu cara me suena – Argentina 2014 TV Series writer – 1 episode
One Hit Wonderland 2014 TV Series documentary writer – 1 episode
Guapas 2014 TV Series writer – 1 episode
Looking TV Series performer – 1 episode, 2014 writer – 1 episode, 2014
American Dad! 2013 TV Series writer – 1 episode
So You Think You Can Dance 2013 TV Series writer – 1 episode
Home & Family 2013 TV Series writer – 1 episode
Welcome to the Basement 2013 TV Series writer – 1 episode
Mein, Lover, sein Vater und ich 2013 TV Movie writer: "Love Shack" – uncredited
Unfinished Song 2012 writer: "Love Shack"
A Turtle's Tale 2: Sammy's Escape from Paradise 2012 writer: "Rock Lobster"
Rust and Bone 2012 writer: "Love Shack"
Showboaters 2011 TV Series writer – 1 episode
Cougar Town 2011 TV Series writer – 1 episode
Paul 2011 as Frederick Schneider, "PLANET CLAIRE"
The X Factor 2010 TV Series writer – 1 episode
Dancing with the Stars 2009 TV Series writer – 2 episodes
Monsters vs. Aliens 2009 writer: "Planet Claire"
Being Erica 2009 TV Series writer – 1 episode
My Name Is Earl 2008 TV Series writer – 1 episode
Ugly Betty 2008 TV Series writer – 1 episode
Album 2008 TV Series writer – 2 episodes
Otis 2008 writer: "52 Girls"
The Pirates Who Don't Do Anything: A VeggieTales Movie 2008 writer: "Rock Monster"
Good Luck Chuck 2007 writer: "Love Shack" – as Frederick Schneider
20 to 1 2007 TV Series documentary writer – 1 episode
Knocked Up 2007 writer: "Rock Lobster"
Rock Band 2007 Video Game writer: "Roam"
I Love the '70s: Volume 2 2006 TV Series writer – 1 episode
Pepper Dennis 2006 TV Series writer – 1 episode
SingStar Rocks! 2006 Video Game writer: "Love Shack"
Taiko: Drum Master 2005 Video Game writer: "Love Shack" – as Frederick Schneider
Karaoke Revolution Volume 3 2004 Video Game "Love Shack"
Min f.d. familj TV Mini-Series lyrics – 1 episode, 2004 music – 1 episode, 2004
Cathouse 2: Back in the Saddle 2003 TV Movie documentary writer: "Love Shack"
Charlie's Angels: Full Throttle 2003 writer: "Planet Claire"
I Love the '80s 2002 TV Series documentary writer – 1 episode
When in Rome 2002/I Video writer: "Roam"
Less Than Perfect 2002 TV Series writer – 1 episode
Wie die Karnickel 2002 writer: "Love Shack"
Queer as Folk 2002 TV Series writer – 1 episode
CKY 3 2001 Video writer: "Rock Lobster"
Scooby-Doo and the Cyber Chase 2001 Video performer: "Scooby-Doo, Where Are You?" – as Fred
Roswell 2000 TV Series writer – 1 episode
The Simpsons 1999 TV Series writer – 1 episode
Mystery Men 1999 writer: "Planet Claire" – as Frederick W. Schneider
The Rugrats Movie 1998 performer: "This World Is Something New to Me"
The Wedding Singer 1998 writer: "Private Idaho"
Mystery Science Theater 3000 1991-1997 TV Series writer – 3 episodes
First Kid 1996 writer: "Love Shack" – as Frederick W. Schneider
It's My Party 1996 writer: "Party Out Of Bounds"
D2: The Mighty Ducks 1994 writer: "GOOD STUFF"
Rising Sun 1993 writer: "LOVE SHACK" – as Frederick Schneider
Ma saison préférée 1993 writer: "52 Girls" – as F. Schneider
Hold Me Thrill Me Kiss Me 1992 lyrics: "Monster" / performer: "Monster"
The Cutting Edge 1992 writer: "Love Shack" – as Frederick Schneider
Frankie and Johnny 1991 writer: "LOVE SHACK" – as Frederick Schneider
Ferris Bueller 1990 TV Series writer – 2 episodes
Full House 1990 TV Series writer – 1 episode
Side Out 1990 writer: "BUSHFIRE", "ROAM' – as Frederick Schneider
Growing Pains 1989 TV Series writer – 1 episode
Doogie Howser, M.D. 1989 TV Series writer – 1 episode
21 Jump Street 1989 TV Series writer – 1 episode
Lobster Man from Mars 1989 writer: "Rock Lobster" – as F. Schneider
Earth Girls Are Easy 1988 writer: "COSMIC THING" – as Fred Schneider III
Demented Top 20 Video Countdown 1988 TV Movie lyrics: "Monster" / performer: "Monster"
Ibigay mo sa akin ang bukas 1987 writer: "Rock Lobster"
Hand in Hand 1985 writer: "Give Me Back My Man"
One-Trick Pony 1980 writer: "Rock Lobster"
Roadie 1980 writer: "Dance This Mess Around"
La bande du Rex 1980 writer: "The B-52s", "6060-842"
The Groovenians 2002 TV Short composer: theme music
Rocko's Modern Life 1995-1996 TV Series vocal – 12 episodes
Each Time I Kill 2007 Tom Saunders
Godass 2000 Roland
The Rugrats Movie 1998 Newborn Baby (singing voice)
Desert Blue 1998 KBLU Radio DJ (voice)
Captain Planet and the Planeteers 1996 TV Series Danny Dazzleduff
The Flintstones 1994 BC-52's
Hangfire 1991 Attorney Allen
A Matter of Degrees 1990 Moonboy
V.I.P. 2000 TV Series special thanks – 1 episode
Dare to Be Different 2017 Documentary post-production Himself – B-52's – singer / songwriter
B-52s: With the Wild Crowd! – Live in Athens 2012 TV Movie Himself
Biography 2010 TV Series documentary Himself
The 7PM Project 2009 TV Series Himself
Late Night with Conan O'Brien 1995-2008 TV Series Himself
The Daily Show 2008 TV Series Himself
Ellen: The Ellen DeGeneres Show 2008 TV Series Himself
The Tonight Show with Jay Leno 2008 TV Series Himself
Best of the Jammys, Volume Two 2007 Video Themselves
100 Greatest Songs of the '80s 2006 TV Series Himself
The L Word 2006 TV Series Himself – The B-52's
TV Party 2005 Video documentary
Trekkies 2 2004 Documentary Himself
Essential Music Videos: Hits of the '80s 2003 Video short Himself (segment "Love Shack")
The Making and Meaning of 'We Are Family' 2002 Documentary Himself
MTV 20: Live & Almost Legal 2001 TV Movie documentary Himself
Bravo Profiles 2001 TV Series documentary Himself
100 Greatest Dance Songs of Rock & Roll 2000 TV Mini-Series documentary Himself
V.I.P. 2000 TV Series Himself
The Simpsons 1999 TV Series Himself
VH1's Karaoke Cabaret 1999 TV Series Himself – Guest
The B-52's Time Capsule: Videos for a Future Generation 79-98 1998 Video Himself (as The B-52's)
Behind the Music 1998 TV Series documentary Himself
The Rosie O'Donnell Show 1998 TV Series Himself
Space Ghost Coast to Coast 1997 TV Series Himself
RuPaul's Christmas Ball 1993 TV Special Himself
Hangin' w/MTV 1992 TV Series Himself
Top of the Pops 1990 TV Series Himself
Funny 1988 Documentary Himself
One-Trick Pony 1980 Himself (as The B-52s)
Saturday Night Live 1980 TV Series Himself – Musical Guest
Peter Andre's 90 Party Hits of the 90s 2014 TV Movie Himself (as B-52s)
Hit So Hard 2011 Documentary Himself
Athens, Ga. – Inside/Out 1987 Documentary Himself – The B-52's (uncredited)
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redpajama_set_name: RedPajamaCommonCrawl


Here in Land Cuckoo we have been busy painting, writing and decorating our handwritten wooden signs. There are so many different designs and beautifully worded quotes and sayings that it is hard to decide which to make next.
Some have fabric embellishments whilst others have stamped designs which are coloured and decorated. All the inks used are water resistant and permanent but as with all wooden products they do not like being in damp environments or in areas where they may be splashed.
If you would like any personalised signs we would be happy to make some for you. Just contact us to discuss your requirements and we will take it from there.


As part of "The Killing Joke" skin pack, Red Hood Joker is coming to Injustice: Gods Among Us.
Before he was The Joker, he was known as Red Hood. Soon you can play as the villain in Red Hood attire in Injustice: Gods Among Us. The game's official Facebook page made the announcement today (May 15).


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redpajama_set_name: RedPajamaGithub


Can my wages be garnished for an online payday loan? The loan was through First Bank of Delware in the amount of $300. I paid them twice that amount in rollovers finance charges?
Yes, it is important for you to find out if the state you are in at all allows payday lending. If your state does not allow PDLs, then you can ask them to refund your money and file complaints against them with your State's Attorney General.
What state are you in? If First Bank of Delaware does not have the license to operate in your state, then they can't file a lawsuit against you or garnish your wages. In such a situation, you can ask them to refund the extra money you have paid to them.
I agree with Anna. If the lenders are licensed in your state, then they can file a lawsuit against you because of non-payment of debt. Once the court issues a judgment against you, then the lender can garnish your wages. If they are not licensed, then they can't take any legal action against you.
You haven't mentioned the name of the state you live in. You will have to check out the pdl laws of your state from the given pagen page: http://www.debtconsolidationcare.com/paydayloan/explain-pdls-laws.html . If you find that they are legal, then they may file a lawsuit against you and get a judgment to garnish your wages.


I think Kingsman: The Golden Circle is one of those fun popcorn movies where you can turn your brain off and just enjoy the ride. It's nothing special however and, when compared to the first movie (Kingsman: The Secret Service, which I would give a B+), that's disappointing.
The main criticism I have with this movie is that where the first one was a great and serious blend of style, warmth, and slight over-the-top action; this one goes way too over the top on so much that it's silly. There are some other plot errors and misuses of characters here or there as well, but that's my main problem with the movie.
Still the performances are as charismatic as the first and you get plenty of laughs. So it's overall entertaining, but nothing that anyone should go out of their way to go see.
I'd give this a C+.


[Clifton, N.J.] DriTac Flooring Products, LLC has launched a "green", single-component acrylic floor primer for interior use on various approved substrates, including concrete, wood, light-weight concrete and gypcrete, called Primer 3000.
According to the company, Primer 3000's concentrated Quick Dry, Bond-Strengthening technology enhances the bond with approved substrates, self-leveling underlayment, gypsum-based underlayment and patches, prior to adhesive application for wood, resilient and carpet tile flooring installations. Primer 3000 is approved for use with all DriTac flooring adhesives and available in 1-gallon containers and 4-gallon pails.
Manufactured in the USA, the floor primer offers easy broom, sprayer, or nap roller application with a spread rate of up to 800 square feet per gallon, depending on application method, subfloor preparation and porosity, the company said.
The company added that Primer 3000's solvent-free, low odor formula is easy to clean and colored green for easy identification. This premium-grade primer also touts DriTac's "Green" Certification, designated for flooring installation solutions that contain zero VOCs and zero solvents.
"The performance characteristics of this product are outstanding. It's easy-to-use with minimal mixing required. Primer 3000 allows us to offer our valued customer-base another premium-grade, eco-friendly flooring installation solution that can be used on its own or as part of our Total Sound Reduction System (SRS)," said Chuck Hall, senior vice president of sales.
According to the company, Primer 3000 can be used in conjunction with DriTac's Total Sound Reduction System, consisting of a layer of approved DriTac flooring adhesive above the primer, topped by a DriTac underlayment beneath a second layer of adhesive, prior to the installation of wood or resilient flooring.


Pressure Cleaning Rowville is the highest rated, professional pressure cleaning & exterior house washing business in Rowville. We service all residential areas throughout Melbourne and Mornington Peninsula.
It is advised for most paths, swimming pools & patio area areas, pavers, tennis courts & keeping walls. For roofing systems, we have a special treatment to prevent tile deterioration and to reduce the risk of water damage.
Roofings can end up being very unpleasant due to natural growths like moss and lichen. Roofs are likewise often discoloured and stained by a prevalent germs called gloecapsa magma. Roofing associations and manufacturers do not recommend high pressure washing to clean roofs. It may remove moss from the roofing system, but the aggressive jets of water might likewise damage tiles, ridge capping and other roofing fittings as well as boost the risk of flooding. There is likewise a good chance that the moss will grow back. Cleaning up with the manufacturers preferred detergent is advised. This is exactly what we do! Softwash roof washing is by far the most effective method to clear moss or other bacterial growths from the roofing system, whenever they are at risk of ending up being a major problem.
Have you got tired looking timber decks? Our team will make them look brand-new once again. We apply a light chemical that will clean up and rejuvenate the timber. This is followed by 2 coats of premium decking oil or stain. Our procedure will make your deck look a million dollars and leave you truly impressed by the outcomes!
Do not let novices practice on your biggest investment. Our expert team of specialists has more than 20 years worth of experience, so we know exactly what we are doing. For your assurance we ensure all of our work, and even better, we have very competitive rates. Our service is guaranteed and we're completely licensed to work on your home.
We works with companies throughout Rowville, supplying environmentally compliant, high pressure steam cleaning and water blasting services that allow organisations to meet hygiene compliance guidelines and provide personnel and visitors with a pleasant environment.
Our certified, licensed and totally guaranteed staff clean both indoor and outdoor areas around your company. Our trusted staff are available to work after hours to prevent any disturbances to your business. We are also qualified and licensed to work at height as our service typically involves tall buildings, which may need abseiling or elevated work platforms.
Our company has a strong credibility among its clients for reliability and craftsmanship. No 2 jobs are alike, so call us to discuss your Bluestone high pressure cleaning Rowville requirements, whether you need a one-off pressure clean or a regular contracted service.


Bad breath. No one wants to admit they have it. No one wants to tell you about it. Even professionals in Dental Hygiene shy away from mentioning it. The fact that there is a billion-dollar oral health care product industry in the U.S. dedicated to combating the problem identifies the size of the problem.
But we want our Concorde students and graduates all to enjoy the benefits of clean, fresh breath. And there are some simple things to know and do that are effective in fighting bad breath and maintaining good Dental Hygiene and good breath.
We enlisted the help of a couple of our Dental Hygiene Program Directors to explain why most of us suffer from halitosis and what we can do to keep our breath fresh.
There are a variety of things that cause bad breath, according to Laurel Sampson, Dental Hygiene Program Director at Concorde's campus in San Diego. These include systemic factors such as disease processes or the ingestion of odiferous foods. However, these account for only 10 percent of oral malodor, Sampson said. The other 90 percent originates in the oral cavity.
"Bad breath is most commonly due to the anaerobic bacteria that inhabit our gum tissue, tonsils and most important, our tongues," Sampson said. "In fact, our tongues are the ideal environment for entrapping all kinds of debris that these nasty bugs like to call dinner. When they digest them, the bacteria produce stinky stuff called 'volatile sulfur compounds,' or VSCs. Voila, bad breath is born!"
So, what can we do about this problem? Sampson said many people attempt to deal with bad breath by brushing their teeth or using mouthwash. But that only takes care of part of the problem. The biggest culprit, the tongue, goes unnoticed in cleaning efforts.
"Some people do try and address this by brushing their tongues," she said, "but with the addition of one simple device to our daily oral care routine, we can be truly effective in chasing the stinky bugs away. That device is called a tongue scraper, and a recent study showed that using one can decrease the VSCs by 75 percent."
"So, if you really want to have sweet breath, go to your local pharmacy and pick one up and use it every day. You'll be amazed at the results!"
Sabrina Santucho, Dental Hygiene Program Director for Concorde's campus in San Bernardino, Calif., listed nine causes/cures for bad breath.
Bacteria lurking between teeth and covering tongue. Brush twice a day and floss once a day. Use a tongue scraper. Floss before bed to prevent morning breath.
Tonsil stones collect bacteria. Use a water flosser to flush out debris. Gargle with warm salt water to clear the bacteria. See your physician if you have tonsillitis.
Acid reflux or ulcer. Use acid blockers.
Onions and garlic. Brush, floss and rinse. Limit amount of garlic and onion intake.
Sinus infection. Treat congestion and see your physician.
Dry mouth. Drink water and stay hydrated.
Have your teeth cleaned every six months.
Tobacco, cigars. Stop using tobacco products.
Chronic bronchitis, diabetes, kidney or liver disease. See your physician.


text:
Brimpsfield Castle mound
A Scheduled Monument in Brimpsfield, Gloucestershire
Longitude: -2.0796 / 2°4'46"W
OS Eastings: 394605.765609
OS Northings: 212756.389275
OS Grid: SO946127
Mapcode National: GBR 2N9.91H
Mapcode Global: VH94M.WPY6
Entry Name: Brimpsfield Castle mound
Scheduled Date: 17 August 1948
English Heritage Legacy ID: GC 195
Civil Parish: Brimpsfield
Traditional County: Gloucestershire
Lieutenancy Area (Ceremonial County): Gloucestershire
Church of England Parish: Brimpsfield St Michael
Church of England Diocese: Gloucester
Motte castle 295m north of Brimpsfield Park.
This record was the subject of a minor enhancement on 10 July 2015. The record has been generated from an "old county number" (OCN) scheduling record. These are monuments that were not reviewed under the Monuments Protection Programme and are some of our oldest designation records.
The monument includes a motte castle situated on a sloping spur on the western upper valley side of a tributary to the River Frome. The motte survives as a flat topped oval mound measuring up to 35m long, 20m wide and 2.5m high surrounded by a ditch of up to 2.5m wide and 1.5m deep. There is a causeway across the ditch to the south east and a slight stony perimeter bank around the summit of the motte indicating a possible tower. It is believed to be the precursor to Brimpsfield Castle situated to the west and the subject of a separate scheduling.
Reasons for Scheduling
Motte castles are medieval fortifications introduced into Britain by the Normans. They comprised a large conical mound of earth or rubble, the motte, surmounted by a palisade and a stone or timber tower. In a majority of examples an embanked enclosure containing additional buildings, the bailey, adjoined the motte. Motte castles and motte-and-bai1ey castles acted as garrison forts during offensive military operations, as strongholds, and, in many cases, as aristocratic residences and as centres of local or royal administration. Built in towns, villages and open countryside, motte castles generally occupied strategic positions dominating their immediate locality and, as a result, are the most visually impressive monuments of the early post-Conquest period surviving in the modern landscape. Over 600 motte castles and motte-and-bailey castles are recorded nationally, with examples known from most regions. Some 100-150 examples do not have baileys and are classified as motte castles. As one of a restricted range of recognised early post-Conquest monuments, they are particularly important for the study of Norman Britain and the development of the feudal system. Although many were occupied for only a short period of time, motte castles continued to be built and occupied from the 11th to the 13th centuries, after which they were superseded by other types of castle.
The motte castle 295m north of Brimpsfield Park survives well and will contain archaeological and environmental evidence relating to its construction, longevity, social, political and strategic significance, social organisation, domestic arrangements, abandonment, relationship and relative chronology with the neighbouring 'castle' and overall landscape context.
PastScape 117548
Brimpsfield Castle
Brimpsfield
Manless Town medieval settlement and the buried remains of a Roman camp
Bowl barrow, known as New Seal Wood barrow, 70m north east of Clements Farm
Miserden
Round barrow 830m north east of Combend Farm
Elkstone
Coberley long barrow
Coberley
Two bowl barrows, known as Climperwell round barrows, 310m south west of Climperwell Farm
Cranham
Coberley Roman Villa
Bowl barrow, known as Buck's Head round barrow, 540m east of Dunley