text:
128 Plain Language Summary
105 Immune and inflammation
29 Neurological
15 Digestive, absorptive and microbiological
14 Hormonal
71 Nutrition
29 Not applicable
21 Psychological
20 Exercise and movement
16 Environment
109 Not applicable
19 Blood
24 Research Support, Non-U.S. Gov't
20 Systematic Review
11 Meta-Analysis
11 Research Support, N.I.H., Extramural
Evaluation of Lactocare® Synbiotic Administration on the Serum Electrolytes and Trace Elements Levels in Psoriasis Patients: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial Study.
Biological trace element research. 2022;200(10):4230-4237
Overweight and obesity as risk factors for COVID-19-associated hospitalisations and death: systematic review and meta-analysis.
BMJ nutrition, prevention & health. 2022;5(1):10-18
1. Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohort.
Hampshire, A, Chatfield, DA, MPhil, AM, Jolly, A, Trender, W, Hellyer, PJ, Giovane, MD, Newcombe, VFJ, Outtrim, JG, Warne, B, et al
EClinicalMedicine. 2022;47:101417
Background: Preliminary evidence has highlighted a possible association between severe COVID-19 and persistent cognitive deficits. Further research is required to confirm this association, determine whether cognitive deficits relate to clinical features from the acute phase or to mental health status at the point of assessment, and quantify rate of recovery. Methods: 46 individuals who received critical care for COVID-19 at Addenbrooke's hospital between 10th March 2020 and 31st July 2020 (16 mechanically ventilated) underwent detailed computerised cognitive assessment alongside scales measuring anxiety, depression and post-traumatic stress disorder under supervised conditions at a mean follow up of 6.0 (± 2.1) months following acute illness. Patient and matched control (N = 460) performances were transformed into standard deviation from expected scores, accounting for age and demographic factors using N = 66,008 normative datasets. Global accuracy and response time composites were calculated (G_SScore & G_RT). Linear modelling predicted composite score deficits from acute severity, mental-health status at assessment, and time from hospital admission. The pattern of deficits across tasks was qualitatively compared with normal age-related decline, and early-stage dementia. Findings: COVID-19 survivors were less accurate (G_SScore=-0.53SDs) and slower (G_RT=+0.89SDs) in their responses than expected compared to their matched controls. Acute illness, but not chronic mental health, significantly predicted cognitive deviation from expected scores (G_SScore (p=0.0037) and G_RT (p = 0.0366)). The most prominent task associations with COVID-19 were for higher cognition and processing speed, which was qualitatively distinct from the profiles of normal ageing and dementia and similar in magnitude to the effects of ageing between 50 and 70 years of age. A trend towards reduced deficits with time from illness (r∼=0.15) did not reach statistical significance. Interpretation: Cognitive deficits after severe COVID-19 relate most strongly to acute illness severity, persist long into the chronic phase, and recover slowly if at all, with a characteristic profile highlighting higher cognitive functions and processing speed. Funding: This work was funded by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (BRC), NIHR Cambridge Clinical Research Facility (BRC-1215-20014), the Addenbrooke's Charities Trust and NIHR COVID-19 BioResource RG9402. AH is funded by the UK Dementia Research Institute Care Research and Technology Centre and Imperial College London Biomedical Research Centre. ETB and DKM are supported by NIHR Senior Investigator awards. JBR is supported by the Wellcome Trust (220258) and Medical Research Council (SUAG/051 G101400). VFJN is funded by an Academy of Medical Sciences/ The Health Foundation Clinician Scientist Fellowship. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.
2. Evaluation of Lactocare® Synbiotic Administration on the Serum Electrolytes and Trace Elements Levels in Psoriasis Patients: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial Study.
Akbarzadeh, A, Taheri, M, Ebrahimi, B, Alirezaei, P, Doosti-Irani, A, Soleimani, M, Nouri, F
Psoriasis is an immune-mediated chronic inflammatory skin disorder characterised by plaques and lesions on the skin. While the etiopathogenesis of psoriasis is not completely understood, various mechanisms have been implicated, including changes in the composition of intestinal microbes, oxidative stress and changes in the levels of certain trace elements. Previous research has shown that fluctuations in trace minerals such as zinc and copper may contribute to the progression and progression of psoriasis. It is known that synbiotics, which are combinations of probiotics and prebiotics, have immune-modulating properties, and they may also enhance the absorption of trace minerals from food when consumed. This double-blind, randomised, placebo-controlled trial was conducted to randomly assign sixty-four patients with mild-to-moderate psoriasis to consume Lactocare, a symbiotic containing seven strains of probiotic bacteria and prebiotic fructooligosaccharide twice daily or a placebo for 12 weeks. Serum trace mineral levels were measured after 12 weeks of treatment, including Fe, K, Ca, Mg, P, Zn, Na, and Cu. A significant improvement in serum levels of zinc and calcium was observed in the symbiotic group after 12 weeks of treatment. Additionally, the symbiotic treatment significantly increased the levels of trace minerals such as Fe, Ca, Mg, P, Zn, and Na within the group compared to the baseline. Fe and Cu levels in the treatment group were affected by sex, with male participants showing significant differences. To evaluate the other benefits of symbiotic preparations in patients with psoriasis, further large-scale studies are required. Healthcare professionals can utilise the research to understand the immune-modulating and anti-inflammatory properties of symbiotic formulations such as Lactocare, as well as to understand how the consumption of Lactocare improves the absorption of trace minerals.
BACKGROUND Despite the exact etiopathogenesis of psoriasis remains unknown, the increasing or decreasing of some trace elements and oxidative stress status are considered to play a role. In this study, the effect of Lactocare® synbiotic on the serum levels of trace elements including Zn, Cu, Mg, Na, Fe, P, Ca, and K in the patients with mild to moderate psoriasis was investigated. METHODS Sixty-four patients with mild to moderate psoriasis were included. Patients were randomly divided into treatment (n═32) and control (n═32) groups. The treatment group received Lactocare® and the control group received a placebo (two times daily for 12 weeks). Eight patients from the intervention group and 18 patients from the control group discontinued the study because of the recent COVID-19 condition. For routine trace element analysis, the blood samples were collected from all patients at the baseline as well as week 12 post-treatment. The serum was then isolated and the serum levels of trace elements including Fe, K, Ca, Mg, P, Zn, Na, and Cu were measured using an automatic electrolyte analyzer. For confirmation of the effect of Lactocare® on the alteration of serum levels of trace elements, intra-group analysis was performed at two interval times: baseline and week 12 post-treatment. RESULTS The serum levels of K, P, and Ca in the placebo group were significantly higher than that of the treatment group at baseline. Serum levels of Zn and Ca were significantly higher in the treatment group compared to the placebo group at week 12 post-treatment. Moreover, a significantly lower serum level of K, P, and Ca in the treatment group at the baseline compared to the placebo group was compensated on week 12 post-treatment. Intra-group analysis in the treatment group showed that the serum levels of Fe, Ca, Mg, P, Zn, and Na was significantly increased at week 12 post-treatment compared to baseline levels. Whereas, intra-group analysis in the control group showed only Ca has a significant difference between baseline and week 12 post-treatment. CONCLUSION The serum levels of Fe, Zn, P, Mg, Ca, and Na are increased significantly 12 weeks after oral administration of Lactocare® in psoriatic patients. The serum level of Fe and Cu is affected by sex at pre- and post-treatment. This study supports the concept that Lactocare® exerts beneficial effects in the gastrointestinal tract to improve mineral absorption in psoriatic patients.
3. Overweight and obesity as risk factors for COVID-19-associated hospitalisations and death: systematic review and meta-analysis.
Sawadogo, W, Tsegaye, M, Gizaw, A, Adera, T
A novel coronavirus named SARS-CoV-2, causing COVID-19, emerged in late 2019. The prognosis of COVID-19 has been consistently reported to worsen with older age, male sex and comorbidities. The aim of this study was to quantify the association between overweight or obesity and COVID-19-related hospitalisations and death, and to assess the magnitude of the association and the potential dose–response relationships. This study is a systematic review and meta-analysis of 208 studies. A total of 3 550 977 participants from over 32 countries were included in this study. Results indicate that being overweight increases the risk of COVID-19-related hospitalisations but not death while obesity and extreme obesity increase the risk of both COVID-19-related hospitalisations and death. In addition, there was a linear dose–response association between obesity categories and COVID-19 outcomes. However, the strength of the association has weakened over time following the pattern of the first wave of COVID-19. Authors conclude that their findings suggest the importance of increased vigilance towards people with excess adiposity. Some preventative measures for this vulnerable group include prompt access to COVID-19 testing and healthcare, as well as prioritisation for COVID-19 vaccination.
Objective: To quantify the current weight of evidence of the association between overweight and obesity as risk factors for COVID-19-related hospitalisations (including hospital admission, intensive care unit admission, invasive mechanical ventilation) and death, and to assess the magnitude of the association and the potential dose-response relationships. Design: PubMed, Embase, Cochrane, Web of Sciences, WHO COVID-19 database and Google Scholar were used to identify articles published up to 20 July 2021. Peer-reviewed studies reporting adjusted estimates of the association between overweight or obesity and COVID-19 outcomes were included. Three authors reviewed the articles and agreed. The quality of eligible studies was assessed using the Newcastle-Ottawa Quality Assessment Scale. Random-effects meta-analysis was used to estimate the combined effects. Results: A total of 208 studies with 3 550 997 participants from over 32 countries were included in this meta-analysis. Being overweight was associated with an increased risk of COVID-19-related hospitalisations (OR 1.19, 95% CI 1.12 to 1.28, n=21 studies), but not death (OR 1.02, 95% CI 0.92 to 1.13, n=21). However, patients with obesity were at increased risk of both COVID-19-related hospitalisations (OR 1.72, 95% CI 1.62 to 1.84, n=58) and death (OR 1.25, 95% CI 1.19 to 1.32, n=77). Similarly, patients with extreme obesity were at increased risk of COVID-19-related hospitalisations (OR 2.53, 95% CI 1.67 to 3.84, n=12) and death (OR 2.06, 95% CI 1.76 to 3.00, n=19). There was a linear dose-response relationship between these obesity categories and COVID-19 outcomes, but the strength of the association has decreased over time. Conclusion: Being overweight increases the risk of COVID-19-related hospitalisations but not death, while obesity and extreme obesity increase the risk of both COVID-19-related hospitalisations and death. These findings suggest that prompt access to COVID-19 care, prioritisation for COVID-19 vaccination and other preventive measures are warranted for this vulnerable group.
4. Lifestyle risk behaviours among adolescents: a two-year longitudinal study of the impact of the COVID-19 pandemic.
Gardner, LA, Debenham, J, Newton, NC, Chapman, C, Wylie, FE, Osman, B, Teesson, M, Champion, KE
The global spread of COVID-19 and subsequent lockdown measures have presented challenges worldwide. Previous research has highlighted the importance of six key lifestyle behaviours, including diet, physical activity, sleep, sedentary behaviour (including recreational screen time), alcohol use and smoking—collectively referred to as the 'Big 6'—for the short-term and long-term health of adolescents. The aim of this study was to examine changes in the prevalence of six key chronic disease risk factors from before to during the COVID-19 pandemic, and also to explore whether differences over time are associated with gender and lockdown status. This study is a prospective cohort study among a large and geographically diverse sample of adolescents. The sample included 983 students (girls = 54.8%) from 22 schools. Results show that: - over the 2-year period, the prevalence of excessive recreational screen time, insufficient fruit intake and alcohol and tobacco use increased. - alcohol use increased more among girls compared to boys. - the prevalence of insufficient sleep reduced in the overall sample; yet, increased among girls. - being in lockdown was associated with improvements in sugar-sweetened beverages consumption and discretionary food intake. Authors conclude that supporting young people to improve or maintain their health behaviours, regardless of the course of the pandemic, is important, alongside targeted research and intervention efforts to support groups that may be disproportionately impacted, such as adolescent girls.
OBJECTIVE To examine changes in the prevalence of six key chronic disease risk factors (the "Big 6"), from before (2019) to during (2021) the COVID-19 pandemic, among a large and geographically diverse sample of adolescents, and whether differences over time are associated with lockdown status and gender. DESIGN Prospective cohort study. SETTING Three Australian states (New South Wales, Queensland and Western Australia) spanning over 3000 km. PARTICIPANTS 983 adolescents (baseline Mage=12.6, SD=0.5, 54.8% girl) drawn from the control group of the Health4Life Study. PRIMARY OUTCOMES The prevalence of physical inactivity, poor diet (insufficient fruit and vegetable intake, high sugar-sweetened beverage intake, high discretionary food intake), poor sleep, excessive recreational screen time, alcohol use and tobacco use. RESULTS The prevalence of excessive recreational screen time (prevalence ratios (PR)=1.06, 95% CI=1.03 to 1.11), insufficient fruit intake (PR=1.50, 95% CI=1.26 to 1.79), and alcohol (PR=4.34, 95% CI=2.82 to 6.67) and tobacco use (PR=4.05 95% CI=1.86 to 8.84) increased over the 2-year period, with alcohol use increasing more among girls (PR=2.34, 95% CI=1.19 to 4.62). The prevalence of insufficient sleep declined across the full sample (PR=0.74, 95% CI=0.68 to 0.81); however, increased among girls (PR=1.24, 95% CI=1.10 to 1.41). The prevalence of high sugar-sweetened beverage (PR=0.61, 95% CI=0.64 to 0.83) and discretionary food consumption (PR=0.73, 95% CI=0.64 to 0.83) reduced among those subjected to stay-at-home orders, compared with those not in lockdown. CONCLUSION Lifestyle risk behaviours, particularly excessive recreational screen time, poor diet, physical inactivity and poor sleep, are prevalent among adolescents. Young people must be supported to find ways to improve or maintain their health, regardless of the course of the pandemic. Targeted approaches to support groups that may be disproportionately impacted, such as adolescent girls, are needed. TRIAL REGISTRATION NUMBER Australian New Zealand Clinical Trials Registry (ACTRN12619000431123).
5. A Systematic Review of the Impact of the First Year of COVID-19 on Obesity Risk Factors: A Pandemic Fueling a Pandemic?
Daniels, NF, Burrin, C, Chan, T, Fusco, F
Current developments in nutrition. 2022;6(4):nzac011
Coronavirus disease 2019 (COVID-19) is one of the most serious infectious disease outbreaks in recent history. Among the factors that can increase the risk of obesity, some seem to play a more prominent role than others such as depression, emotional eating, sedentary lifestyle and the socioeconomic status. The aim of this study was to explore the indirect effects of the first year of COVID-19 on obesity and its risk factors. This study is a systematic review of 87 studies with over 350,000 participants. Results show that: - overall, there was a general trend of weight gain during the pandemic. - there were differences in dietary changes, with some studies showing an improvement in diet. - some beneficial effects were observed in the dieting domain, such as higher consumption of home-cooked meals and healthy food (e.g., vegetables). However, there was an increasing trend in the overall food and alcohol consumption. - financial hardship and job loss were unavoidable consequences of the pandemic lockdown. However, although the impact of the countermeasures used to curb the COVID-19 pandemic was evident on obesity risk factors, none of the studies included in the research explored the direct impact of the risk factors on obesity itself. Authors conclude by pointing out the need for future research that aims at strengthening the link between stressful circumstances and a rise in risk factors for obesity and weight gain.
Obesity is increasingly prevalent worldwide. Associated risk factors, including depression, socioeconomic stress, poor diet, and lack of physical activity, have all been impacted by the coronavirus disease 2019 (COVID-19) pandemic. This systematic review aims to explore the indirect effects of the first year of COVID-19 on obesity and its risk factors. A literature search of PubMed and EMBASE was performed from 1 January 2020 to 31 December 2020 to identify relevant studies pertaining to the first year of the COVID-19 pandemic (PROSPERO; CRD42020219433). All English-language studies on weight change and key obesity risk factors (psychosocial and socioeconomic health) during the COVID-19 pandemic were considered for inclusion. Of 805 full-text articles that were reviewed, 87 were included for analysis. The included studies observed increased food and alcohol consumption, increased sedentary time, worsening depressive symptoms, and increased financial stress. Overall, these results suggest that COVID-19 has exacerbated the current risk factors for obesity and is likely to worsen obesity rates in the near future. Future studies, and policy makers, will need to carefully consider their interdependency to develop effective interventions able to mitigate the obesity pandemic.
6. Evidence for the Efficacy of a High Dose of Vitamin D on the Hyperinflammation State in Moderate-to-Severe COVID-19 Patients: A Randomized Clinical Trial.
Sarhan, N, Abou Warda, AE, Sarhan, RM, Boshra, MS, Mostafa-Hedeab, G, ALruwaili, BF, Ibrahim, HSG, Schaalan, MF, Fathy, S
Medicina (Kaunas, Lithuania). 2022;58(10)
Vitamin D insufficiency is an example of the factors which may affect snowballed COVID-19 risk and mortality. The aim of this study was to determine whether the clinical results and prognoses of COVID-19 patients are enhanced by supplementing a high dose of vitamin D relative to the conventional low dose. This study is a randomised controlled trial of 116 patients. Participants were randomly assigned to one of the two groups i.e. 58 patients received treatment with low-dose vitamin D and 58 received treatment with high-dose vitamin D. Results show that the incidence of mechanical ventilation, intensive care unit hospitalisation, death, sepsis, and atrial fibrillation in the high-dosage vitamin D group was considerably reduced compared to the low-dosage vitamin D group. However, the need for high oxygen was significantly higher in the high-dose vitamin D group compared to the low-dose group. Additionally, there was a significant difference in the monitored parameters before and after treatment in favour of the high-dose vitamin D group, which were significantly lower in the high-dose vitamin D group compared to the low-dose group. Authors conclude that the sooner micronutrients are administered to outpatients, the better the outcome, especially before supportive or specific treatment is commenced.
Background and Objectives: Vitamin D supplementation plays a key effect in lowering cytokine storms among COVID-19 patients by influencing the activity of the renin-angiotensin system and the production of the angiotensin-2 converting enzyme. The study was conducted to explore the effect of high-dose intramuscular vitamin D in hospitalized adults infected with moderate-to-severe SARS-CoV-2 in comparison with the standard of care in the COVID-19 protocol. Materials and Methods: Two groups of patients were compared in this prospective randomized controlled trial as the vitamin D was administered orally to group 1 (alfacalcidol 1 mcg/day) and intramuscularly to group 2 (cholecalciferol 200,000 IU). One hundred and sixteen participants were recruited in total, with fifty-eight patients in each group. Following the Egyptian Ministry of Health's policy for COVID-19 management, all patients received the same treatment for a minimum of five days. Results: A significant difference was recorded in the length of hospital stay (8.6 versus 6.8 days), need for high oxygen or non-invasive mechanical ventilator (67% versus 33%), need for a mechanical ventilator (25% versus 75%), clinical improvement (45% versus 55%), the occurrence of sepsis (35% versus 65%), and in the monitored laboratory parameters in favor of high-dose vitamin D. Moreover, clinical improvement was significantly associated with the need for low/high oxygen, an invasive/non-invasive mechanical ventilator (MV/NIMV), and diabetes, while mortality was associated with the need for MV, ICU admission, atrial fibrillation, chronic obstructive pulmonary disease, asthma, and the occurrence of secondary infection. Conclusions: Our study showed that high-dose vitamin D was considered a promising treatment in the suppression of cytokine storms among COVID-19 patients and was associated with better clinical improvement and fewer adverse outcomes compared to low-dose vitamin D.
7. Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial.
De Niet, S, Trémège, M, Coffiner, M, Rousseau, AF, Calmes, D, Frix, AN, Gester, F, Delvaux, M, Dive, AF, Guglielmi, E, et al
Nutrients. 2022;14(15)
Literature shows that having enough vitamin D can help prevent many diseases, such as heart disease, bone disease and cancer. Recent data also showed that vitamin D can reduce the risk of respiratory tract infections, and particularly, the risk of viral infections. The aim of this study was to assess whether the proposed dosing regimen of a daily dose of 25,000 international units (IU) vitamin D administered over 4 consecutive days, followed by a weekly dose of 25,000 IU, was adequate to rapidly increase the concentrations of calcifediol in patients hospitalized with COVID-19 and to explore its impact on hospital length and other clinical outcomes of the disease. This study is an interventional, randomized, parallel, two-treatment, two-arm, double-blind and placebo-controlled pilot study, carried out in one clinical site in Belgium. The patients (n=50) were randomized in the two different treatment groups (vitamin D (n=26) or placebo (n=24)). Patients participated in the study for a maximum of 9 weeks, including an up to 6-week treatment period and a maximum of 3-week follow-up period. Results show that the study's regimen was adequate to rapidly raise the calcifediol level above 20 ng/mL and improve the clinical outcome of patients requiring hospitalization for COVID-19. In fact, administration of cholecalciferol significantly reduced the hospital length of stay, reduced the duration of supplemental oxygen and improved the clinical status assessed by the World Health Organisation scale. Authors conclude that further studies with a larger number of patients are needed in order to further confirm their study's findings.
Retrospective studies showed a relationship between vitamin D status and COVID-19 severity and mortality, with an inverse relation between SARS-CoV-2 positivity and circulating calcifediol levels. The objective of this pilot study was to investigate the effect of vitamin D supplementation on the length of hospital stay and clinical improvement in patients with vitamin D deficiency hospitalized with COVID-19. The study was randomized, double blind and placebo controlled. A total of 50 subjects were enrolled and received, in addition to the best available COVID therapy, either vitamin D (25,000 IU per day over 4 consecutive days, followed by 25,000 IU per week up to 6 weeks) or placebo. The length of hospital stay decreased significantly in the vitamin D group compared to the placebo group (4 days vs. 8 days; p = 0.003). At Day 7, a significantly lower percentage of patients were still hospitalized in the vitamin D group compared to the placebo group (19% vs. 54%; p = 0.0161), and none of the patients treated with vitamin D were hospitalized after 21 days compared to 14% of the patients treated with placebo. Vitamin D significantly reduced the duration of supplemental oxygen among the patients who needed it (4 days vs. 7 days in the placebo group; p = 0.012) and significantly improved the clinical recovery of the patients, as assessed by the WHO scale (p = 0.0048). In conclusion, this study demonstrated that the clinical outcome of COVID-19 patients requiring hospitalization was improved by administration of vitamin D.
8. Prognostic and Therapeutic Role of Vitamin D in COVID-19: Systematic Review and Meta-analysis.
Dissanayake, HA, de Silva, NL, Sumanatilleke, M, de Silva, SDN, Gamage, KKK, Dematapitiya, C, Kuruppu, DC, Ranasinghe, P, Pathmanathan, S, Katulanda, P
The Journal of clinical endocrinology and metabolism. 2022;107(5):1484-1502
Vitamin D is implicated in optimum function of the immune system. Its deficiency has been linked to susceptibility to respiratory infections. It is postulated that vitamin D deficiency/insufficiency is also associated with COVID-19. The aim of this study was to determine the association between vitamin D deficiency/insufficiency and susceptibility to COVID-19, its severity, mortality and role of vitamin D in its treatment. This study is a systematic review and meta-analysis of seventy-six publications. Results show increased odds of developing COVID-19, progression to severe COVID-19 and death in people with vitamin D deficiency/insufficiency. In fact, people who developed COVID-19, severe COVID-19 and fatal disease had lower 25-hydroxy vitamin D concentration compared to people without COVID-19 or non-severe COVID-19 or non-fatal COVID-19 respectively. Authors conclude that Vitamin D deficiency/insufficiency may increase the risk of developing COVID-19 infection and susceptibility to more severe disease.
PURPOSE Vitamin D deficiency/insufficiency may increase the susceptibility to coronavirus disease 2019 (COVID-19). We aimed to determine the association between vitamin D deficiency/insufficiency and susceptibility to COVID-19, its severity, mortality, and role of vitamin D in its treatment. METHODS We searched CINAHL, Cochrane library, EMBASE, PubMED, Scopus, and Web of Science up to May 30, 2021, for observational studies on association between vitamin D deficiency/insufficiency and susceptibility to COVID-19, severe disease, and death among adults, and, randomized controlled trials (RCTs) comparing vitamin D treatment against standard care or placebo, in improving severity or mortality among adults with COVID-19. Risk of bias was assessed using Newcastle-Ottawa scale for observational studies and AUB-KQ1 Cochrane tool for RCTs. Study-level data were analyzed using RevMan 5.3 and R (v4.1.0). Heterogeneity was determined by I2 and sources were explored through prespecified sensitivity analyses, subgroup analyses, and meta-regressions. RESULTS Of 1877 search results, 76 studies satisfying eligibility criteria were included. Seventy-two observational studies were included in the meta-analysis (n = 1 976 099). Vitamin D deficiency/insufficiency increased the odds of developing COVID-19 (odds ratio [OR] 1.46; 95% CI, 1.28-1.65; P < 0.0001; I2 = 92%), severe disease (OR 1.90; 95% CI, 1.52-2.38; P < 0.0001; I2 = 81%), and death (OR 2.07; 95% CI, 1.28-3.35; P = 0.003; I2 = 73%). The 25-hydroxy vitamin D concentrations were lower in individuals with COVID-19 compared with controls (mean difference [MD] -3.85 ng/mL; 95% CI, -5.44 to -2.26; P ≤ 0.0001), in patients with severe COVID-19 compared with controls with nonsevere COVID-19 (MD -4.84 ng/mL; 95% CI, -7.32 to -2.35; P = 0.0001) and in nonsurvivors compared with survivors (MD -4.80 ng/mL; 95% CI, -7.89 to -1.71; P = 0.002). The association between vitamin D deficiency/insufficiency and death was insignificant when studies with high risk of bias or studies reporting unadjusted effect estimates were excluded. Risk of bias and heterogeneity were high across all analyses. Discrepancies in timing of vitamin D testing, definitions of severe COVID-19, and vitamin D deficiency/insufficiency partly explained the heterogeneity. Four RCTs were widely heterogeneous precluding meta-analysis. CONCLUSION Multiple observational studies involving nearly 2 million adults suggest vitamin D deficiency/insufficiency increases susceptibility to COVID-19 and severe COVID-19, although with a high risk of bias and heterogeneity. Association with mortality was less robust. Heterogeneity in RCTs precluded their meta-analysis.
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9. Effects of Vitamin D Serum Level on Morbidity and Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis.
Hu, Y, Kung, J, Cave, A, Banh, HL
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2022;25:84-92
COVID-19 caused by SARS-CoV-2 infection is associated with severe acute respiratory syndrome resulting from the excessive inflammatory response at 5-7 days. It has been shown that low Vitamin D serum concentration is associated with increased pneumonia and viral respiratory infections. The aim of this study was to determine the clinical effects of Vitamin D serum concentration in COVID-19 patients. This study is a systematic review and meta-analysis of 20 studies. Results show that Vitamin D serum concentration was not statistically associated with mortality and ICU admission, ventilator support requirement, and length of hospital stay. Authors conclude that additional randomized controlled trials are required to provide a specific supplemental vitamin dose and Vitamin D serum concentration.
PURPOSE It has been shown that low Vitamin D serum concentration is associated with increased pneumonia and viral respiratory infections. Vitamin D is readily available, inexpensive, and easy to administer to subjects infected with COVID-19. If effective in reducing the severity of COVID-19, it could be an important and feasible therapeutic intervention. METHODS We performed a systematic review and meta-analysis of the literature to determine the effects of Vitamin D serum concentration on mortality and morbidity in COVID-19 patients. The primary objectives were to determine if Vitamin D serum concentration decrease mortality, ICU admissions, ventilator support, and length of hospital stay in COVID-19 patients. RESULTS A total of 3572 publications were identified. Ultimately, 20 studies are included. A total of 12,806 patients aged between 42 to 81 years old were analyzed. The pooled estimated RR for mortality, ICU admission, ventilator support and length of hospital stay were 1.49 (95% CI: 1.34, 1.65), 0.87 (95% CI: 0.67, 1.14), 1.29 (95% CI: 0.79, 1.84), and 0.84 (95% CI -0.45, 2.13). CONCLUSION There is no statistical difference in mortality, ICU admission rate, ventilator support requirement, and length of hospital stay in COVID-19 patients with low and high Vitamin D serum concentration.
Sponsored Journal Article
10. Probiotic improves symptomatic and viral clearance in Covid19 outpatients: a randomized, quadruple-blinded, placebo-controlled trial
Gut Microbes is an open access journal which publishes research on intestinal microbiota, gastrointestinal, liver and cardiac disease, cancer, and irritable and inflammatory bowel conditions. The intestinal microbiota plays a pivotal role in human physiology. Characterizing its structure and function has implications for health and disease, impacting nutrition and obesity, brain function, allergic responses, immunity, inflammatory bowel disease, irritable bowel syndrome, cancer development, cardiac disease, liver disease, and others. Gut Microbes provides a platform for presenting and discussing cutting-edge research on all aspects of microorganisms populating the intestine.
Covid-19 is a disease of the lungs, which differentially affects those it infects. There are currently no therapies that have been approved for use in Covid-19 patients. However recent evidence has highlighted a possible link between the gut and the lungs, known as the gut-lung axis indicating a new avenue for investigation. Previous trials on probiotics have indicated a role in infections such as cold and flu highlighting a possible role in Covid-19 infection. This randomised control trial of 300 Covid-19 patients aimed to determine the efficacy and safety of a probiotic known as AB21 containing several strains of Lactoplantibacillus plantarum and Pediococcus acidilactici. The results showed that after 30 days, the rate of remission from Covid-19 was higher in those who were given the probiotic, which was regardless of age, sex, confounding metabolic illness, viral load, and days from symptom start. Symptom duration and viral load were also reduced with probiotic use. Higher amounts of Covid-19 associated immune activity and lower biomarkers of inflammation were also reported following probiotic use. Probiotic use was shown to be safe during Covid-19 infection. It was concluded that the use of AB21 in Covid-19 patients was safe and associated with increased viral and symptom resolution compared to placebo, possibly driven by immune alterations via the gut-lung axis. This study could be used by healthcare professionals to seriously consider the use of this probiotic to stimulate immune activity and aid viral and symptom resolution in patients suffering from Covid-19.


We are soaking up the last few days of our summer holidays before we return back to work next week, and the children to school the following. Our mission these holidays was to firstly, try to relax and de-stress, as well as spend some much needed quality family time together, and also hopefully get more of our old bungalow painted. I think our mission has been accomplished!
Jackalopes - yes, I love Jackalopes. Along with the new addition to our wall, this gorgeous necklace arrived in the mail via Etsy last week. I LOVE it (sorry Mum - I know Jackalopes creep you out a bit).
If you love Jackalopes too, I have a blog button just for you at the bottom of my site.
We've loved roasting marshmallows by the fire in the evenings.
Master marshmallow roaster - he has perfected the art of marshmallow roasting!
Helping Poppa get the sand out of the cockles before we devour them!
Mummy daughter date. Love this precious, tender hearted princess of mine. Such a sweetie and fabulous little helper.
This cute Dala print purse made by the fabulous Becky - I love Dala horses!!
I haven't loved painting the house, but I've loved seeing the result of painting it... farewell hideous orange bungalow!
Loved having a date night with Symon... dinner and a movie - bliss! Oh, and hello to the lovely lady I met while at dinner (Fat Camel), a blog reader all the way from Canterbury who recognised Symon and came to say hello!
Finally, loving my Whangarei bloggers. These girls are an amazing bunch. I have especially loved reading these two story's lately, Liz and her journey to New York, and Arna-Lise and her journey of having an 11 week premature baby. Click on the links to read and the image below to visit more.
i am so glad you guys have had such an awesome holiday Kristy. So deserved.
Love that beautiful pouch Becky made you!
glad you guys are having a welcome break. Its going to be a cracker of a year... so get ready....!
Is a jackalop even a real animal? Never heard of it!


The Association for Conflict Resolution has just announced it will be organizing a Conflict Resolution Day for October 20, 2005. ACR aims to raise public awareness about the benefits of conflict resolution by organizing events and activities across the nation. They invite anyone with an interest in this issue to take action by organizing a community presentation, talking to a reporter or contacting a policy maker about conflict resolution. For more ideas about how to participate, visit www.ACRnet.org/crday or email acr@ACRnet.org.


The Friends is a nonprofit organization formed to support, promote and aid the library. Membership is open to anyone. Membership dues, fund raising efforts, and gifts to the Friends are used to purchase materials and present programs beyond the library's regular operating budget.
A regular mini-sale is held throughout the year. The Friends also sell Mansfield afghans and book bags. See display models in the library. The Friends are now accepting donations for their book sales! Books that are in excellent condition are accepted! Please call the library before bringing in your donations.
Book Bags may be purchased at the front desk. These sturdy canvas bags are wonderful for your daily trips to the library! All proceeds benefit the library. They are useful, and make great gifts too.


To those who don't know, you could be considered a menace. You don't do things the gentle way, and your ends always justify your means. But to those in need, there's no greater hero. So go enjoy your time with your Merry Crew. We've got your ring covered.


I had 72 collection points listed on an offline map, when I connected to wifi & synchronized only 8 points uploaded. Many of the points missing had photos attached via the built in tool to capture and attach an image. I did not access my iPhone 5s camera to capture the image. There were no images stored on my camera.


text:
Ilmet – biurowiec w dzielnicy Wola w Warszawie, przy alei Jana Pawła II 15, przy rondzie ONZ.

Opis
Budynek został wzniesiony w latach 1995–1997. Inwestorem była austriacka firma Ilbau, a projektantami Miljenko Dumenčić oraz Mirosław Kartowicz. Większość powierzchni zajmują biura, na dwóch najniższych piętrach znajdują się punkty usługowe. Trzykondygnacyjny parking podziemny może pomieścić 182 samochody.

W holu głównym budynku znajduje się podświetlana plastikowa tuba zawierająca akt położenia kamienia węgielnego z 12 czerwca 1995 roku, polskie i austriackie dzienniki oraz kilka polskich banknotów sprzed denominacji.

Charakterystycznym elementem budynku od jego zbudowania jest obracające się logo firmy Mercedes-Benz na dachu. Na fasadzie znajduje się również tablica upamiętniająca 50-lecie Organizacji Narodów Zjednoczonych, co stanowi nawiązanie do nazwy ronda.

W marcu 2011 pojawiły się informacje o planach szwajcarskiego UBS, właściciela budynku, dotyczących zburzenia wieżowca i postawienia w jego miejsce większego budynku. Plany te zostały potwierdzone w listopadzie tego samego roku – projekt duńskiej pracowni architektonicznej Schmidt Hammer Lassen został zwycięzcą konkursu na budynek w tym miejscu. 188-metrowy wieżowiec Warsaw One ma oferować ok. 60 000 m² powierzchni biurowej, a jego budowę pierwotnie planowano w latach 2012–2016, w czym przeszkodził światowy kryzys gospodarczy. Obiekt ma zostać zbudowany zgodnie z nowoczesnymi standardami umożliwiając otrzymanie certyfikatu LEED lub BREEAM.

W lipcu 2021 rozpoczęły się wyburzenia wewnątrz budynku.

Przypisy

Linki zewnętrzne

Wieżowce w Warszawie
Wieżowce poniżej 100 metrów
Mirów (Warszawa)
Budynki biurowe w Warszawie
Warszawa

redpajama_set_name: RedPajamaWikipedia


Learning about the wonders of God's creation can be fun! Here are some of the creation adventures enjoyed by different groups. One of our favorites is Mt. St. Helens, which shows that catastrophic changes in geography can take place in minutes rather than millions of years.
Mt. St. Helens 35 years after the eruption.


Jeffrey Allen is the author of two chapbooks, Simple Universal (Bronze Man Books 2007) and bone and diamond (H_NGM_N Books 2013), and holds an MFA from Columbia College Chicago. His poems, reviews, and interviews can be found in or are forthcoming from Another Chicago Magazine, The Bakery, Forklift Ohio, Handsome, H_NGM_N, RHINO, Sundog Lit, TriQuarterly, and elsewhere. He serves as the Educational Outreach Coordinator for H_NGM_N Books and Poetry Editor for phantom limb.


text:
The Best Things to Do in Metro Phoenix July 11-17
Frank Lloyd Wright's Taliesin West in Scottsdale Makes UNESCO World Heritage List
Author Elizabeth Winder Discusses Sylvia Plath in Fashion at Phoenix Art Museum Friday
Becky Bartkowski
Becky Bartkowski | October 10, 2013 | 11:00am
"I dreamed of New York, I am going there," Sylvia Plath wrote in a diary.
When the aspiring writer was in college and 21 years old, she spent a month working as an intern at Mademoiselle in New York, living at the Barbizon, and experiencing the city. Though it's hard to imagine the author of The Bell Jar in the midst of the glitz and glamour of a fashion magazine and all its frivolity, Elizabeth Winder explores this 26-day period of Plath's life in her biography Pain, Parties, Work: Sylvia Plath in New York, Summer 1953.
See also: Phoenix Fashion Week 2013 at Talking Stick Resort: The Good, The Bad, and The Ugly Winder, a poet herself, details that month of Plath's life and how it shaped the remainder of it. She'll discuss and sign the book at Phoenix Art Museum Friday, October 11, during Arizona Costume Institute Nouveau's 1950s-themed fundraiser benefitting the museum's fashion gallery.
ACI Nouveau is the under-35 division of the Arizona Costume Institute with members who are fashion enthusiasts. The group works to raise money and awareness for ACI, as well as the museum's prestigious fashion collection.
The lecture begins at 7 p.m. Signed copies of Winder's book will be available for purchase. After the talk, during which Winder will provide insight into Plath's experiences in the '50s fashion world and how they impacted her, light snacks will be available, along with cocktails at a cash bar. DJ Kim E-Fresh will spin, while the Saks Fifth Avenue cosmetics team will give Dior makeovers. Gift bags will be furnished by Saks and Kendra Scott Jewelry.
Tickets to the ACI Nouveau's fourth annual fundraiser event are $30 and available via www.arizonacostumeinstitute.com or by calling 602-257-1222.
Follow Jackalope Ranch on Facebook, Twitter and Pinterest.
Becky Bartkowski is an award-winning journalist and the arts and music editor at New Times, where she writes about art, fashion, and pop culture.
Twitter: @beckybartkowski
Trending Arts & Culture
7 Summer Film Series Happening in Metro Phoenix
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redpajama_set_name: RedPajamaCommonCrawl


text:
Notes From the Field: Serving the Homeless with Convoy of Hope
Today, we're shining a spotlight on one of our nonprofit partners, Convoy of Hope, who teamed up with a local organization in order to bring light to the homeless population of the Ozarks.
Notes From the Field: Off-The-Grid Missions Empowers Deaf Bahamians After Hurricane Dorian
In this edition of Notes From the Field, we are lucky to have a guest post from Angela Maria Nardolillo of Off-The-Grid Missions. Off-The-Grid Missions is the only organization in the world dedicated to providing Deaf and Hard-of-Hearing individuals access to life-saving resources in remote, isolated and disaster-stricken regions around the world.
Notes From the Field: How Haiti Mission, Inc. Created a "Generational Transformation"
In the latest edition of Notes From the Field, we hear from Tom Morrison of Starpoint Charitable Project. Tom founded Starpoint Charitable Project in 2018 to raise money for solar lighting solutions in Haiti, in partnership with Haiti Mission, Inc.
Solar Light and Power After the Storm: Mercy Corps Responds to Hurricane Florence
LuminAID worked with international humanitarian organization, Mercy Corps, to raise funds for and distribute 1,300 PackLite Hero 2-in-1 Superchargers in North Carolina. The PackLite Hero Superchargers help families to feel safe at night with extra-bright LEDs and allows them to charge their phones and stay connected with emergency services and family members.
Notes From the Field: How World Central Kitchen Fed Hurricane-Ravaged Florida
When Hurricane Michael wreaked havoc along the Florida panhandle, World Central Kitchen was there to feed the survivors by the light of LuminAID solar lantern + phone chargers. Chef Jose Andres, the founder of WCK, flew down to Panama City to help with relief efforts by cooking and distributing hot meals.
Chicago4PR Campaign Raises Over 10K Solar Lantern for Puerto Rico Hurricane Relief
After a devastating hurricane season, LuminAID partnered with local Chicago organizations to get more safe light to those in need. Through the Chicago4PR campaign, Chicagoans came together to raise solar lanterns for families without power in Puerto Rico. Thanks to the generosity of LuminAID supporters and Chicago organizations, more than 10,000 solar lanterns were pledged for disaster relief in Puerto Rico.


text:
The Talbot Brothers
Chris & Ian Talbot
Ian and Chris Talbot, two well known Empire Premier 1 players, come from a table tennis family. The father, Des, and all the six sons played. The boys started playing in primary school. Ian, Ross, Geoff and Chris won the Wellington Primary Schools Boys Singles Titles. Ross won the Primary Schools Singles three times and was only 9 years of age when he won for the first time in 1965. Ross won the Wellington Senior and Junior Secondary Schools Boys Singles in 1970.
Des Talbot took over the running of the Porirua Table Tennis Club. The family dominated the Club Singles Title. Des, won the title when it was first held in 1969, and also 1975. Ian won in 1970 and 1972-73. Ross won seven times,1971,1974,1977-78 and 1982-84. Murray won 1980-81. Chris won eight time, 1985-92. Only non family members to win were Tony Rutledge (1976) and Steve Corbett (1979). Chris Talbot still has the cup as the Porirua Club folded up after 1992.
The Talbot brothers had their own basketball team in the Porirua league, with Ross and Bryan the stars. Bryan went on to represent Porirua . Ian, Chris and Bryan have run marathons. Ian has run 20 marathons with a best time of 2 hours 29 minutes 16 seconds (London 1981). Ian has also run triathons and been on the Round Taupo Cycle Challenge (160 km) 3 times. Chris played senior cricket for North City and caught NZ opening batsman Bruce Edgar out.
Murray, Ian, Ross and Chris all represented Kapiti at the NZ Championships. Murray, Ross and Chris have all been the top ranked man in Kapiti. After the Kapiti Association folded up Ian and Chris joined the Empire Club. Chris has played Premier 1 since 1994 and Ian from 2000.They were in the Empire team that finished runner up in Premier 1 (2009). They have both won the Empire Club Singles. Chris 5 times (1999-2001, 2003, 2006) and Ian (2005). And together they have won the club doubles 10 times (1999-2006, 2009-2010).
Ian and Chris Talbot have represented New Zealand in the veterans table tennis test against Australia at Easter. Ian has won the NZ Over 45 Men's Doubles twice, with Lindsay Ward (2003) and with his brother, Chris (2008). They have had much success in the NZ Masters Games in Wanganui. Ian has won 12 Gold Medals and Chris 10 Gold medals.
-Malcolm Wong
TTW:Club Empire, TTW:International, TTW:Player Profile


Waldo is a photo-finding platform empowering consumers to toss their selfie sticks, put their phones back in their pockets, and live in the moment. Waldo is the only platform that removes all of the friction in getting photos of you taken by others and creates new opportunities for photographers to market and sell their photos. Users can enjoy lifes most precious moments and automatically receive images taken of them right on their phones or share images of others theyve taken without having to lift a finger whether between friends and family or a professional photographer.
Were looking for a highly motivated, detail-oriented self-starter to join our team as a Client Support team. Youre energetic and have a passion for client satisfaction, because youll become the front line and friendly voice of Waldo, assisting our customers with onboarding and training. Youre a problem solver, as youll help our customers with the technical and account issues that they may face. And youre a promoter, who will delight in seeing our customers using all of the many features that Waldo offers. This is an opportunity to join a startup on the ground floor!
Promote best practices among our clients so that they are using Waldo to its full advantage, and present new capabilities that they havent yet purchased (which creates leads for our sales team).
Manage internal and external projects diligently, collaboratively, and with our clients needs at the forefront of your actions.
Be the voice of your clients and their markets, providing input to Product Managers on new services, products, and features.


In lieu of a ribbon-cutting, Rick Rainey went to work on a 20-by-8-foot shipping container with a cutting torch.
The Builders United project manager proceeded to slice a "window" in the side of the steel container, the first step toward converting it into a rectangular home for a military veteran.
The demonstration Tuesday at Veterans Village in downtown Las Vegas set in motion the first phase of a project focused on housing veterans closely together. Ten shipping containers will be converted into prototype homes on the 4-acre Veterans Village No. 2 site on North 21st Street.
The nonprofit Veterans Village hopes to expand the project on a different downtown site to include 100 of the no-frills residences.
Other cities, including Reno and Seattle, have adopted similar strategies to use tiny homes to address homelessness.
The materials and labor needed to convert the containers have been donated by the private sector — something Stalk says is necessary in order to tackle homelessness in Southern Nevada.
Peter Guzman, the president of the Las Vegas Latin Chamber of Commerce, described the project as "the cure to the cancer" of homelessness.
Construction of The Village by Sands Cares, named for the major contributor to the project, is expected to be completed in March. Veterans Village will soon start accepting applications from its residents, who live in apartment units, to move in.
Stalk said he will lease the units, which will be compliant with the federal Americans with Disabilities Act, to low-income veterans for no more than $650 a month, with utilities and campus services included. With federal housing subsidies, veterans should pay no more than $200 out of pocket a month, he said.
The new containers were donated and shipped from China, he said.
On Tuesday, Stalk was also presented with congressional certificates of appreciation from U.S. Rep. Dina Titus and U.S. Sen.-elect Jacky Rosen. Laborers Local 872 also pledged to donate $25,000 to the project.
Ron Reese, a spokesman for Las Vegas Sands Corp., said Veterans Village has succeeded by taking chances.
"We view this as an investment, not a charitable donation …. an investment in an important cause: our veterans," he said.
Las Vegas City Councilman Steve Seroka also attended the groundbreaking.
Seroka, a former Air Force colonel and fighter pilot, gestured to a nearby model shipping container with hardwood floors and painted drywall that fits a bedroom, kitchenette, living room, bathroom and shower. He said the setup compared favorably with some military quarters.
In addition to providing housing alternatives, Las Vegas has a duty to assist veterans and their families as they transition out of the service and into the community, Seroka said.
"We can take care of the next generation to prevent them from needing this kind of housing by reaching out to them the moment they leave the service," he said.
Funding for the project has been made possible through Sands Cares, the Raiders Foundation, Pisos dispensary, Operation Tiny Home and Laborers Local 872.
Development partners include Martin-Harris Construction, Builders United, Moser Architecture Studio, Collins Civil Engineering Group, MSA Engineering Consultants, Nova Engineering, Aria Landscape Architecture, XL Landscape Development and Ambient Solar Energy.


text:
Benjamin Vincent, né le , est un journaliste français de radio et de télévision.

Biographie

Benjamin Vincent fait ses premiers pas dans la presse écrite au sein de l'hebdomadaire Le Journal du dimanche en 1989. Diplômé de l'École supérieure de journalisme de Lille en 1992 (spécialité « radio »), il remporte la bourse Lauga d'Europe 1, ex-aequo avec Christophe Delay.

Après son service militaire, il rejoint en 1994 l'équipe qui va lancer, autour d'Axel Duroux, RTL2 (d'abord baptisé RTL1). En 1998, il participe au lancement de L'Équipe TV, chaine de télévision d'information sportive concurrente d'InfoSport en présentant le deuxième journal télévisé de la chaîne. À l'été 2002, il crée son entreprise et lance Mac Info, un hebdomadaire consacré au monde lié aux produits d'Apple Inc..

En , dix ans après avoir quitté Europe 1, il revient rue François . En décembre, il est l'un des rares journalistes français à se trouver en Irak le jour où Saddam Hussein est capturé.

Il réalise parallèlement des reportages pour C dans l'air, une émission diffusée sur France 5 et produite par Maximal Productions.

En 2005, à l'arrivée de Jean-Pierre Elkabbach à la présidence d'Europe 1, il devient le spécialiste des nouvelles technologies au sein de la rédaction de la station. Il est nommé rédacteur en chef « numérique » en novembre 2006. Pendant trois ans, il coprésente une émission hebdomadaire d'une heure, sur la high-tech, Générations Europe 1 - nouvelles technologies d'abord en trio avec Pierrick Fay et Catherine Nivez, puis en duo avec Pierrick Fay.

En parallèle, à la rentrée 2007, il renoue avec la télévision, en rejoignant l'équipe de chroniqueurs de Revu et corrigé présentée par Paul Amar sur France 5, en tant que spécialiste du Web.

À la rentrée de septembre 2008, Benjamin Vincent devient présentateur des journaux dans le 5 h - 7 h d'Europe 1 en semaine, avec Jean-Michel Dhuez. En mai 2009, il lance avec Pierrick Fay le site Teknologik consacré à la high-tech. Pendant la saison 2008/2009, Benjamin Vincent assure une chronique consacrée à Internet dans Médias, le magazine, une émission de télévision hebdomadaire sur les médias présentée par Thomas Hugues sur France 5.

À l'été 2009, après avoir coprésenté avec Véronique Mounier un pilote non retenu pour une émission quotidienne en access prime-time sur France 5 finalement confiée à Alessandra Sublet avec C à vous, il rejoint la tranche 12 h - 14 h de la chaîne d'information en continu i>Télé pour y animer Le forum de l'info aux côtés de Maya Lauqué du lundi au vendredi de 12 h à 14 h jusqu'à son départ de la chaîne en janvier 2010 « d'un commun accord ».

À partir de , il anime un magazine mensuel de 26 minutes sur LCP-AN. Produit par  Œil, Tout dépend 2 emmène une personnalité politique de premier plan à la rencontre successive de deux jeunes. En octobre 2010, il présente sur la chaîne TMC le magazine SOS vies en danger consacré à .

Distinction

Notes et références

Journaliste français du XXe siècle
Journaliste français du XXIe siècle
Animateur français de télévision
Présentateur de journaux télévisés sur i-Télé
Élève de l'École supérieure de journalisme de Lille
Naissance en février 1969


text:
Q: Why do ref-qualifier together with cv-qualifier on operator overloading allow rvalue assignment? Adding a ref-qualifier to an operator will remove the possibility to do rvalue assignment
for example, compiling the following with g++ -std=c++14 bar.cpp && ./a.out
#include <cstdio>

struct foo
{
    void operator+=(int x) & { printf("%d\n", x+2); }
};

int main()
{
    foo() += 10;
}

will give you
$ g++ -std=c++14 bar.cpp && ./a.out
bar.cpp: In function 'int main()':
bar.cpp:14:14: error: passing 'foo' as 'this' argument discards qualifiers [-fpermissive]
   14 |     foo() += 10;
      |              ^~
bar.cpp:6:10: note:   in call to 'void foo::operator+=(int) &'
    6 |     void operator+=(int x) & { printf("%d\n", x+2); }
      |          ^~~~~~~~

you can of course "fix" this by adding an explicit &&
#include <cstdio>

struct foo
{
    void operator+=(int x) & { printf("%d\n", x+2); }
    void operator+=(int x) && { printf("%d\n", x+3); }
};

int main()
{
    foo() += 10;
}

output
$ g++ -std=c++14 bar.cpp && ./a.out
13

But adding a const & will also let you call += on the struct instance.
#include <cstdio>

struct foo
{
    void operator+=(int x) & { printf("%d\n", x+2); }
    void operator+=(int x) const & { printf("%d\n", x+4); }
};

int main()
{
    foo() += 10;
}

output
$ g++ -std=c++14 bar.cpp && ./a.out
14

To "fix" this, the const && must be explicitly deleted
#include <cstdio>

struct foo
{
    void operator+=(int x) & { printf("%d\n", x+2); }
    void operator+=(int x) const & { printf("%d\n", x+4); }
    void operator+=(int x) const && = delete;
};

int main()
{
    foo() += 10;
}

output
$ g++ -std=c++14 bar.cpp && ./a.out
bar.cpp: In function 'int main()':
bar.cpp:14:14: error: use of deleted function 'void foo::operator+=(int) const &&'
   14 |     foo() += 10;
      |              ^~
bar.cpp:9:10: note: declared here
    9 |     void operator+=(int x) const && = delete;
      |          ^~~~~~~~

Why is this? Why do adding the ref-qualifier implicitly remove the rvalue assignment? But adding a cv-qualifier together with ref-qualifier seem to implicitly add the rvalue assignment?
I'm sure I'm missing something obvious here. But Google-Wan Kenobi doesn't seem to be able to help me understand.

A: Because rvalues could be bound to lvalue-reference to const. Just same as the following code:
foo& r1 = foo();       // invalid; rvalues can't be bound to lvalue-reference to non-const
const foo& r2 = foo(); // fine; rvalues can be bound to lvalue-reference to const

BTW: The overload qualified with rvalue-reference wins in overload resolution when calling on rvalues. That's why you mark it as delete explicitly works as expected.

redpajama_set_name: RedPajamaStackExchange


text:
namespace llvm { \
    extern const char name ## LinkVar; \
    __attribute__((used)) static const char *const name ## LinkObj = \
      &name ## LinkVar; \
  }
#else
// Otherwise use a constructor call.
#define FORCE_DEFINING_FILE_TO_BE_LINKED(name) \
  namespace llvm { \
    extern const char name ## LinkVar; \
    static const IncludeFile name ## LinkObj ( &name ## LinkVar ); \
  }
#endif

/// This macro is the counterpart to FORCE_DEFINING_FILE_TO_BE_LINKED. It should
/// be used in a .cpp file to define the name referenced in a header file that
/// will cause linkage of the .cpp file. It should only be used at extern level.
#define DEFINING_FILE_FOR(name) \
  namespace llvm { const char name ## LinkVar = 0; }

namespace llvm {

/// This class is used in the implementation of FORCE_DEFINING_FILE_TO_BE_LINKED
/// macro to make sure that the implementation of a header file is included
/// into a tool that uses the header.  This is solely
/// to overcome problems linking .a files and not getting the implementation
/// of compilation units we need. This is commonly an issue with the various
/// Passes but also occurs elsewhere in LLVM. We like to use .a files because
/// they link faster and provide the smallest executables. However, sometimes
/// those executables are too small, if the program doesn't reference something
/// that might be needed, especially by a loaded share object. This little class
/// helps to resolve that problem. The basic strategy is to use this class in
/// a header file and pass the address of a variable to the constructor. If the
/// variable is defined in the header file's corresponding .cpp file then all
/// tools/libraries that \#include the header file will require the .cpp as
/// well.
/// For example:

/// <tt>extern int LinkMyCodeStub;</tt>

/// <tt>static IncludeFile LinkMyModule(&LinkMyCodeStub);</tt>

/// @brief Class to ensure linking of corresponding object file.
struct IncludeFile {
  explicit IncludeFile(const void *);
};

}

#endif

redpajama_set_name: RedPajamaGithub


text:
Уэст-Йорк () — боро в округе Йорк, штат Пенсильвания, США. В 2010 году в боро проживало  человек.

Географическое положение и транспорт

Боро расположен в центре округа Йорк в 3 км на запад от города Йорк. По данным Бюро переписи населения США Уэст-Йорк имеет площадь 1,6 квадратных километра.

История
Боро Уэст-Йорк первоначально называлось Эбертон. Оно было инкорпорировано 21 июня 1904 года. Боро включило в себя фермы Генри Эберта, Джейкоба Алдингера, Хермана Хоука. Населённый пункт начал быстро расти, когда были основаны каретная мастерская Мартина, молочная ферма Эшли и Бэйли, мебельная компания Уэст-Йорка, мебельная компания Джейкоби, обувная фабрика Уэст-Йорка и другие компании.

Население
По данным переписи 2010 года население Уэст-Йорка составляло 4617 человек (из них 47,9 % мужчин и 52,1 % женщин), в боро было 1926 домашних хозяйств и 1105 семей. Расовый состав: белые — 82,1 %, афроамериканцы — 8,5 %, коренные американцы — 0,5 %, азиаты — 0,8 % и представители двух и более рас — 4,8 %. На 2014 год население боро Уэст-Йорк было распределено по происхождению следующим образом: 8,4 % — американское, 33,6 % — немецкое, 9,2 % — ирландское, 3,4 % — итальянское происхождение.

Население города по возрастному диапазону по данным переписи 2010 года распределилось следующим образом: 27,0 % — жители младше 18 лет, 3,6 % — между 18 и 21 годами, 60,2 % — от 21 до 65 лет и 9,2 % — в возрасте 65 лет и старше. Средний возраст населения — 33,3 года. На каждые 100 женщин в Йорке приходилось 91,8 мужчин, при этом на 100 совершеннолетних женщин приходилось уже 88,2 мужчин сопоставимого возраста.

Из 1926 домашних хозяйств 57,4 % представляли собой семьи: 32,7 % совместно проживающих супружеских пар (15,5 % с детьми младше 18 лет); 18,5 % — женщины, проживающие без мужей и 6,1 % — мужчины, проживающие без жён. 42,6 % не имели семьи. В среднем домашнее хозяйство ведут 2,40 человека, а средний размер семьи — 3,06 человека.

Экономика
В 2014 году из 3507 человек старше 16 лет имели работу 2361. При этом мужчины имели медианный доход в  долларов США в год против  долларов среднегодового дохода у женщин. В 2014 году медианный доход на семью оценивался в  $, на домашнее хозяйство — в  $. Доход на душу населения —  $ в год. 12,5 % от всего числа семей в Уэст-Йорке и 17,4 % от всей численности населения находилось на момент переписи за чертой бедности.

Примечания

Ссылки

 Департамент полиции Уэст-Йорка

Боро Пенсильвании
Населённые пункты округа Йорк (Пенсильвания)


Creating engaged employees by finding the right seat on the bus for each team member to drive productivity, performance and profit.
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AILLA Awarded NEH Grant for Endangered Language Project
The National Endowment for the Humanities (NEH) has awarded a Documenting Endangered Languages Preservation Grant of $227,365 to Patience Epps and Susan Smythe Kung of the Archive of the Indigenous Languages of Latin America (AILLA) for support of their upcoming project entitled "Archiving Significant Collections of Endangered Languages: Two Multilingual Regions of Northwestern South America."
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Architecture Exhibit Celebrates a Century of Sutton Hall
The University of Texas Libraries celebrates the 100th anniversary of a Forty Acres original with the latest edition of the "To Better Know a Building" exhibition series.
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Call for Thoma Latin American Art Scholars
In collaboration With the Thoma Foundation and the Blanton Museum of Art, LLILAS Benson Latin American Studies and Collections is pleased to announce a call / call for proposals for the grants Thoma for Research in Virreinal Arte Latinoamericano (Thoma Visiting Scholars in Spanish Colonial Art). The Scholarships Thoma will fund short-term visits for six scholars to conduct research on South American colonial art based on a long-term loan to the Blanton by the Carl & Marilynn Thoma Foundation . Researchers will have access to over thir
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UT Libraries Launches New Search Tool
The Libraries has launched a new beta search tool that offers an easy way to find a variety of library resources, services and tools in a single search.
Read more about UT Libraries Launches New Search Tool
Art Historian Barnitz Honored with Event, Exhibit
The Benson Latin American Collection is pleased to announce the acquisition of the archive of Jacqueline Barnitz (1923–2017). The life and collection of the late art historian and professor emeritus will be celebrated in the Benson's Rare Books and Manuscripts Reading Room on Tuesday, March 27, at 3 p.m. Selected materials from the archive will be on view in an exhibition titled The Legacy of Jacqueline Barnitz.
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Excessive Noise Turns Six with "Green Paw"
Excessive Noise is an occasional concert series hosted by the Fine Arts Library. Organized by Russell Podgorsek — who earned his doctorate at the Butler School of Music and is an employee of the Fine Arts Library — the series provides students with an opportunity to perform chamber and solo works beyond those required by their degree programs. It also provides an opportunity for the premier of original works beyond the classroom. While generally in the classical vein, Excessive Noise features work from a variety of traditions and perspectives.
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Alexander Archive Acquires Buildings of Texas Collection
The Alexander Architectural Archives at the Architecture and Planning Library has acquired source materials for a publication that provides a comprehensive survey of architecture in the Lone Star State.
Read more about Alexander Archive Acquires Buildings of Texas Collection
Gaspar de Alba Donates Archive to Benson
The Benson Latin American Collection is pleased to announce the acquisition of the Alicia Gaspar de Alba Papers. Contents include drafts of creative works such as Calligraphy of the Witch (2007), La Llorona on the Longfellow Bridge (2003), and Sor Juana's Second Dream(1999) as well as notable academic publications like [Un]framing the "Bad Woman" (UT Press, 2014), Our Lady of Controversy (UT Press, 2011), and Making a Killing (UT Press, 2010).
Read more about Gaspar de Alba Donates Archive to Benson


Overnight stay at Comfort Suites, Vicksburg, located next to restaurants and an outlet mall.
Taken to the Old Country Store to eat the best fried chicken around!
Treated out to celebratory dinner - 100 miles!
& Transportation back up to Jackson, when you're ready.


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San Andreas Review
Jeremy Lebens	 May 28, 2015 3 Comments
Directing8.5
Writing7.5
Overall8.0
San Andreas is an impressive summer blockbuster. It's big, fun, exciting and a nearly perfect disaster movie, with director Brad Peyton giving the great Roland Emmerich a run for his money. Dwayne Johnson brings his usual charisma and intense energy, while the 3D actually manages to heighten the thrills and excitement.
Brad Peyton's San Andreas is a near-perfect disaster flick, providing its viewers with lots of large-scale action and excitement, plus a decent-enough story, led with energy and charisma by Dwayne 'The Rock" Johnson. Plus, the film's use of 3D only heightens the thrills and makes the film that much more bad ass when viewed on the largest and loudest screen in town.
The San Andreas fault is a ticking time-bomb waiting to happen, with a massive series of earthquakes just around the corner, waiting to strike. Or at least that's how director Brad Peyton sets up the epic disasters that follow in his latest film San Andreas.
Dwayne Johnson plays rescue-chopper pilot Ray and the film follows Ray around California as he survives and saves people from earthquakes, tsunamis and other disasters in an attempt to save his daughter and re-unite his family.
San Andreas may sound like a silly and far-fetched disaster movie that focuses mostly on the special effects and size of destruction and less behind the science or common sense of it all and that's one hundred percent correct and exactly why Brad Peyton may have cracked the surface, thus creating a highly satisfying and richly detailed disaster movie that's nearly perfect.
There's a lot going on in San Andreas, yet everything has a reason and everything makes perfect sense in terms of playing by the own film's rules. That's the trick to disaster movies that so many filmmakers fumble with and yet Peyton achieves such great things with such a simple and compact story.
He doesn't over-bloat the film with unneeded intricate plot detail or side character attention and instead smartly maps out a film that puts emphasis on large-scale disaster, while also rounding the rough corners with simple, but not too distracting family drama, which definitely plays up on the sap, but is tolerable and never overbearing.
The running time is a quick and painless 114 minutes, yet Peyton crams in so much action. And the action is well-shot, from both a large-scaled scope and a 3D approach that only builds and adds onto the already massive look and feel of the film.
Dwayne Johnson, Carla Gugino and Alexandra Daddario star in the film, with Johnson sharing most of the screen-time with Daddario and together the two present a fine balance to the film's tones, with Johnson's manly bad ass dad figure swooping across the screen with style and typical Rock energy, while Daddario's daughter role is actually given some thought and not simply dumbed down to the helpless and stupid daughter.
Watching Daddario's character actually outsmart most of the people around her is refreshing and almost groundbreaking for a disaster film, especially with Johnson getting the top bill and most of the promotional spotlight.
One could argue that San Andreas is her film and they'd be right in doing so, because her character's progression is what keeps the heart beating, despite Johnson's dramatic chops slightly improving when the film needs a moment of sadness.
Johnson is no dramatic actor, but he does the character justice and keeps the tears from feeling too forced, which plagued his last serious role in Snitch. He's improving and it's noticeable.
San Andreas is no Oscar winner for its performances though and that shouldn't come as much of a surprise to anyone, even though Paul Giamatti proves to be a perfect match for playing that side character that no one really knows or cares about, yet he carries the most important knowledge for the film's characters and their fates.
Director Brad Peyton deserves some recognition and attention for somehow out-Emmeriching the master disaster filmmaker Roland Emmerich (2012, Independence Day, The Day After Tomorrow and so on).
Peyton manages to successfully trim almost all of the unneeded fat off of San Andreas to make it feel much more lean and effective, while also maximizing his budget with some truly groundbreaking special effects work that make the film feel very big and expensive.
Also, his use of 3D is astonishing, adding lots of depth and layers to the film, with various dirt and debris jumping off of the screen, while also infusing a lot of fun camerawork that gives a much better sense of depth.
Lots of folks have been talking about Tomorrowland or even the upcoming Jurassic World when it comes to most-anticipated summer blockbusters, but San Andreas might surprise many with just how enjoyable and entertaining it is.
It looked like a fairly generic and basic disaster flick, but it's actually the complete opposite. Peyton's direction is productive and lively, while Johnson and Daddario's performances come with enough likable moments to actually add up to something.
See San Andreas on the largest and loudest screen possible and for once, do bother with the 3D upgrade, preferably IMAX 3D if possible.
San Andreas is the biggest and best disaster movie that I've seen in quite a long time and it just might be one of the better summer blockbusters to hit in 2015.
Hugo Johnstone-Burt
San Andreas Movie Review
Jeremy Lebens
I talk about films longer than anyone is willing to listen. My favorite genres are horror, sci-fi and action (better be R-rated!) and I have a slight obsession with Blu-rays and the whole high definition craze.
7.2	 December 26, 2020 0
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