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Justia Patents Of Print MediumUS Patent for Method and apparatus for controlling peak power requirements of a printer Patent (Patent # 5,349,905)
Method and apparatus for controlling peak power requirements of a printer
Apr 5, 1993 - Xerox Corporation
A thermal ink jet printer incorporates a copy speed feed control for reducing peak power requirements. Printing data supplied to the printer is scanned to determine image density or power consumption to dry ink in a dryer is determined. The speed of the sheet transport system is controlled in accordance with the image density so that, at high image densities, the speed of the sheet at the printer and/or at the dryer is reduced. A controller controls the speed of a drive motor driving the transport system in accordance with a determination of the density of the printed image from image print data or energy required for ink drying. A printer employing on-demand workstations having potentially high peak power usages can be made compatible with conventionally provided power supply systems.
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This invention relates to reducing the peak power requirements of printers, particularly printers having work stations that are powered on an on-demand basis.
2. Description of Related Developments
Many types of reprographic equipment, such as those using electrophotographic reproduction techniques, are in use. Such equipment incorporates work stations that are maintained at predetermined operating power levels. To assure acceptable image quality, a relatively constant speed sheet transport system is used. As a consequence, the power input required by such equipment tends to be relatively constant, after start-up conditions are reached.
Recently, thermal ink jet printing has been developed as an alternative to the fused toner imaging techniques used in electrophotographic and other hard copy imaging equipment. Thermal ink jet printing is basically an on-demand system that requires almost no power at idle conditions but requires high power under high speed, high image density conditions. An advantage of ink jet printing is that image quality does not deteriorate at high throughput rates, in comparison to other methods. The power input excursions in the duty cycle of thermal ink jet printers result from the need to boil the liquid component of the ink (usually water) twice, once in jetting the ink onto the recording medium and a second time in drying the ink and fixing it on the recording medium. To maintain overall power consumption low, it is desirable to use on-demand dryers, such as microwave dryers, that also have widely varying power input requirements governed by copy speed and ink density. For an ink jet printer or marking engine operating at 30 copies per minute, printing with black ink only at a high image density, approximately 2500 watts of power are required. For a 90 copy per minute process color printer, with an high image density, approximately 15,000 watts are required. These power requirements tend to come in bursts, one as the thermal ink jet printer bars are operated and the other as the recording medium passes through the microwave dryer. This results in significant peak power excursions over the duty cycle of the printer. However, from a user acceptability standpoint, it is desirable that normal power lines, such as the 1.5 KVA receptacle terminated lines commonly found in offices and homes, be capable of meeting the power requirements of such printers. This avoids the cost of installing special power lines and allows flexibility in placement of the equipment.
It is an object of the invention to reduce peak power requirements of printers.
It is a further object of the invention to attenuate peak power requirements of printers employing on-demand workstations, such as thermal ink jet printers.
These and other objects of the invention are achieved by printing apparatus in which the transport speed of the recording medium is inversely correlated to the density of the image printed on the recording medium. The support member for carrying the recording medium along the feed path of the printing apparatus is driven by a variable speed drive. Input power requirements are anticipated by scanning printing data supplied to the printer to determine the density of the image to be printed or by assessing power levels required for drying ink in a dryer. A control system utilizes the anticipated power requirements to control the speed of the drive so that, for high density images, the speed of the recording medium as it travels past the printer, the dryer or both is reduced in proportion to the density of the image. By control of the residence time of the recording medium in the printing and/or drying stations, peak power requirements at each station can be attenuated and controls simplified.
FIG. 1 is a side schematic illustration of a printer embodying the invention; and
FIG. 2 is a schematic of a motor control system for the printer illustrated in FIG. 1.
DESCRIPTION OF PREFERRED EMBODIMENTS
The following description is in the context of a thermal ink jet printer, which serves as a good basis for illustration because it has a duty cycle with widely varying power requirements. However, the invention has applicability in a wide variety of printer designs in which peak power requirements are desirably lessened.
Referring to FIG. 1, a printing apparatus 10 includes a housing 12 within which is disposed a transport belt 14. Preferably, the belt 14 is foraminous and is associated with a vacuum source (not shown) for causing recording media, such as sheets S.sub.1 and S.sub.2 to adhere temporarily to the belt 14 in the transport regions 14a and 14b, so that the sheets do not move or shift with respect to the belt, thereby assuring precise positioning of the sheets as they travel through the equipment.
The transport belt 14 is endless and is supported on a series of rollers 16. At least one roller, 16a, is driven by a variable speed drive motor 18. The belt 14 is also entrained on a roller 24a for driving an encoder 24. The encoder 24 can be a conventional optical or inductive encoder, but is preferably a design employing a laser read compact disc, as disclosed in copending Application Ser. No. 07/769,290 filed Oct. 1, 1991, assigned to the assignee of the present invention, the disclosure of which is incorporated herein by reference.
A printer 20 is disposed within the housing and can comprise a single full-width thermal ink jet printing bar 21a for printing black and white documents. If color printing is desired, the printer 20 includes additional printer bars, 21b, 21c, 21d, conventionally one for each of the three colors, cyan, magenta and yellow or red, green and blue. Downstream of the printer 20 is a dryer 26, preferably of a microwave type.
Recording media such as the sheets S.sub.1 and S.sub.2 are fed into the printing apparatus through a sheet inlet 28 onto the transport belt 14. The sheets are carried by the transfer belt 14 to the printer 20. The portion of the sheet directly beneath the print bars is supported by the plate 22. An arrangement that has been found to be particularly useful is to mount the encoder 24 beneath the plate 22, with the displaced portion of the belt disposed about the roller 24a of the encoder 24. In this arrangement, a space is created beneath the thermal ink jet bars for providing a maintenance station (not shown) for the ink jet bars for maintaining them in operative condition. Such maintenance stations are known and no further detailed explanation thereof is believed necessary.
The encoder 24 provides signals indicative of the position of the belt, which are utilized to control operation of workstations, such as printer 20 and dryer 26 to compute the speed of the belt 14 and otherwise control operation of the printer.
The drive motor 18 drives at least one of the rollers 16, such as roller 16a, which in turn causes movement of the belt 14 on the rollers 16. At inlet 28, the sheets (S.sub.1, S.sub.2) are fed onto to the belt 14. The vacuum arrangement associated with the belt holds each sheet on the belt so that it does not move transversely or longitudinally with respect to the belt after being placed on it. The belt 14 carries the sheets to the printer station 20, where an image is formed by the jetted ink on the upwardly facing surface of the sheets. The length of the support plate 22 is shorter than the length of the sheet being fed so that a portion of the sheet is always adhered to the belt and moves with the belt. After passing the printer 20, the sheets are introduced into the dryer 26 and the water or other liquid component of the ink deposited on the paper is driven off as a vapor. Continued movement of the belt 14 drives the sheet to the outlet 30 for removal or subsequent handling. Thus, the inlet 28, the belt 14 and the outlet 30 define a feed path through the printing apparatus 10.
In general, the printing apparatus 10 is controlled so that the process speed is instantaneously variable in response to the density of the ink being jetted and/or dried. For low density imaging (approximately 6% to 20% density), motor 18 is driven at high speed. As the density increases, the speed of drive motor 18 is reduced correspondingly so that the power required by the printer and/or the power required by the dryer is maintained below a predetermined level. In this manner, it is possible to have each sheet travel through the printer at varying rates of speed depending upon the density of the printing in each area of the sheet.
FIG. 2 schematically shows one embodiment of a control system for the printing apparatus 10. A source of print data 34, such as a video source, provides printing data to the thermal ink jet printing bars 28a, 28b, 28c and 28d for controlling the formation of images on the recording medium. The data can be in the form of bitmap data and is conventionally supplied in raster fashion, on a line by line basis. In the embodiment shown, the density monitor 36 receives printing data from line 40 and, on the basis of raster pixel density, provides a signal to the servo-control 38 for setting the speed of drive motor 18. The density monitor 36 can comprise a stand alone microprocessor or be implemented in a microprocessor which controls the printer. From the printing data, the density monitor determines the appropriate timing for effecting speed changes according to the position of the recording medium on the vacuum transport belt 14. Appropriate speeds can be selected by the density monitor on the basis of values in a stored look-up table, which values are empirically determined for the printer. That is, the table correlates a range of density levels with a copy speed at each density level which maintains the power consumption of the print station 20 or the dryer 26 (or both) below a predetermined power level.
Alternately, the density monitor 36 can detect printhead current to develop speed control signals to supply to servo controller 36. The above-mentioned density determining arrangements can be implemented by routine programming techniques. Accordingly, no further details regarding the density monitor 36 are necessary.
As an alternative to monitoring the printing data, the microwave dryer 26 can be monitored to provide speed control information. Ideally, a microwave dryer, such as dryer 26, is operated at a fixed power output. A portion of this output couples with the ink to heat the ink and dry it. The amount of power in excess of that necessary to dry the ink is absorbed in a dummy load. In the dummy load, the excess microwave power is converted to heat, which is dissipated. The amount of power dissipated in the dummy load is directly related to the density of the ink on the recording medium and the speed at which the recording medium proceeds through the dryer. If very little power is absorbed in the dummy load, this is an indication that the dryer is operating close to optimum speed for the density of printing being dried. If the power dissipated in the dummy load is high, it is an indication that the amount of ink to be dried is low, resulting from the density and/or the speed of the recording medium being low. Under these conditions, the speed of the belt 14 can be increased so that more ink is brought into the drier per unit time. In FIG. 2, the dotted line 40' illustrates connection of the density monitor 36 to the microwave dryer 26 as an alternative control arrangement. Line 40' is provided with a signal representative of the power dissipated in the dummy load of the microwave dryer 26 and the density monitor 36 provides a control signal to servo-control 38 for controlling drive motor 18 so that the amount of power dissipated in the dummy load is minimized.
Because the density of the printing can be determined from printing data supplied to the printer or from power usage of the dryer, the control system can anticipate or determine the need for speed changes. Also, because the drying zone has a finite width in the process direction, this has the effect of integrating speed change effects. Varying the process speed controls the residence time of each sheet or portion thereof in the dryer 26. Thus, the dryer can operate in timed on/off mode, eliminating the need for a variable energy power supply and thereby reducing cost of the dryer unit.
In a typical design, using an 800 watt microwave dryer, image densities between 6% to 20% would require a drive speed yielding about 45 81/2.times.11" copies per minute, slow to 11 copies per minute for 100% highlight color and to 5 copies per minute for 230% process color, all at a peak power demand below 1.5 KVA. Copy rates can be increased by providing for white space acceleration, commonly in leading and trailing border edges of the sheets. That is, when an area of the recording medium which is to receive no printing is disposed at the printing station 20 or the dryer 26, as determined by the density monitor 36, the speed of the belt 14 is raised quickly so that the unprinted portion of the recording medium traverses the work stations quickly.
The preferred embodiments of the invention have been described herein, and are intended to be illustrative and not limiting. Various changes can be made in relation to the preferred embodiments without departing from the spirit and scope of the invention as defined in the appended claims.
1. A printing apparatus comprising:
means for depositing a dryable ink on a recording medium to form an image;
a microwave dryer having an energy absorbing means for absorbing microwave energy not consumed in drying ink, said energy absorbing means comprises a dummy load for dissipating excess microwave energy;
a conveying member for conveying the recording medium with an image formed thereon through the dryer;
determining means for determining the energy, consumed by the dryer to dry the ink on the recording medium, said determining means including means for sensing the amount of energy dissipated in the dummy load; and
means for controlling the speed of the conveying member in accordance with the energy consumption determined by the determining means.
a dryer having an energy absorbing means for absorbing energy not consumed in drying ink;
determining means for determining the energy, consumed by the dryer to dry the ink on the recording medium, said determining means including means for sensing the amount of energy absorbed in the energy absorbing means; and
3588445 June 1971 Hopkins
4033263 July 5, 1977 Richmond
4460676 July 17, 1984 Fabel
4469026 September 4, 1984 Irwin
4482239 November 13, 1984 Hosono et al.
4547803 October 15, 1985 Richards
4566014 January 21, 1986 Paranjpe et al.
4634262 January 6, 1987 Imaizumi et al.
4719489 January 12, 1988 Ohkubo et al.
4738553 April 19, 1988 Uemura et al.
4970528 November 13, 1990 Beaufort et al.
5021805 June 4, 1991 Imaizumi et al.
5189436 February 23, 1993 Yoshikawa
"Japanese Patent English Abstract", Pat. No. 58-220764; Jun. 18, 1982; Shiegek. Shimizu.
Filed: Apr 5, 1993
Date of Patent: Sep 27, 1994
Assignee: Xerox Corporation (Stamford, CT)
Inventors: Thomas N. Taylor (Rochester, NY), Frederick A. Donahue (Walworth, NY)
Primary Examiner: Edgar S. Burr
Assistant Examiner: John S. Hilten
Law Firm: Oliff & Berridge
Application Number: 8/43,615
Current U.S. Class: Of Print Medium (101/488); 101/4241; With Means Whereby Material To Be Heated May Be Passed Continuously Through Heated Area (e.g., Conveyor) (219/388); Drying Or Curing (347/102)
International Classification: B41L 3514;

redpajama_set_name: RedPajamaCommonCrawl


Is there an uncreated creator we call God? The answer must be either "YES" or "NO". You have no alternative! Answering "present," or "I don't know," is the same as answering, "NO". You must choose to ignore a word of evidence to answer, "NO".
Every other thing that is "true" rests upon that truth.
If you choose to ignore the evidence and deny there is an uncreated creator (i.e. God), You are obliged to live consistently with that belief. Trying to do so is absurd!
God created a set of rules to govern everything that exists. Outside those boundaries is chaos. Within them is peace. Humans are created with the choice to stay within, or violate those, "laws of Nature and of Nature's God." Violating them releases chaos, which, in turn, disturbs the peace of others.
He is to be feared (reverenced) above all gods.
These thoughts are prompted by my understanding of the rapid decline of American culture. In Old Testament history, when enough people cried out to God for help – God intervened, He raised up a righteous leader around whom the people could rally.
His reports are covering stories the other networks will not touch. As is to be expected the other networks are attempting to smear him as a "conspiracy nut." I am convinced "The Blaze" reporting is among the best news sources available. Currently, he is exposing sound documentation of what appears to me to be treasonous administration involvement with Saudi Arabia.
Is Glenn Beck "the" righteous leader around whom the people could rally? I believe he would say, "No." He is just another American like, so many of us, desperately concerned for the loss of what God has done in America, to give hope to a world in darkness.
Our kids, their parents, and many of their grand-parents have little understanding of what we have lost. They do not understand the "news", such as it is, and decide to ignore it. I know MANY really good men – fathers, business men, teachers, even pastors – who appear to me to have no clue about the cause of the chaos around them, or the price they and their family are about to pay for their ignorance and apathy. I am using these posts to shout from the house-tops! If you wish – circulate them.
In American colonial days, our "founding pastors" were used mightily in teaching biblical principles of government to their flocks. That does not appear to me to be the case today. Were our churches ablaze with righteous liberty and understanding, I believe America would again be an inspiration to the dark world. I pray that God would again raise up such men.
Pastors are a special group of people. They are servants of a different Master. One day, they must answer to the Lord, for the condition of their flock. We, you and I, are not aware of how the Lord may be leading them. I caution – Use care before criticizing a pastor.


November proved acted more like typical October with volatility taking over the globe. We had everything with trade wars, elections, more Brexit drama, and tons of earnings reports. As for Games Workshop, investors had fully digested the cryptic CEO message from October which still left left many scratching their heads.
With all that, lets see how Games Workshop performed over the month of November.
For most of November Games Workshop was losing ground, and strangely enough the slide can be timed to all the major Brexit negotiation announcements throughout November.
Here is how the stock is doing year to date.
Stock is till down from September highs, but with typically good holiday results their is little chance the stock will end below where it was for the start of the year. Games Workshop won't though see doubling results it has experienced over the last couple years, which all goes to say Games Workshop might be reaching the upper limits for a company of its size and scope.
As for investor news, Games Workshop had a quiet month with some stocks changing hands, with one little oddity happing as Kevin Roundtree CEO sold some stock to buy a new house!


You are the my clan/family's wealth. You are the reason of my life.
Forgive me who didn't know this truth till now.
Oh, Madhava! The one who is accompanied by Sita and Lakshmana! You of the auspicious form and extraordinary deeds! The one who protects the yagas and the one worshiped by the Son of Vayu, Hanuman! The one who removes the devotees sins like the sun removes the frost; the one with the sweet and deep sound! Hey Raghava, the highest, brightest and the most beautiful! The one who killed Ravana, Lord of Lanka! Janaki's husband with the eyes of the sun and moon! You are the wealth of Tyagaraja's clan!


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8. Biotransformation of drugs
Phase I biotransformation
Phase II biotransformation
Influence of biotransformation on the biological activity of drugs
Alterations in biotransformation
Page created on January 7, 2019. Last updated on January 7, 2022 at 21:51
The body metabolizes drugs in two steps; phase I and phase II
Phase I, where the drug is oxidized, reduced or hydrolysed to yield an -OH group
The most important enzymes in phase I reactions are the CYP450 enzymes, monoamine oxidase, alcohol dehydrogenase, etc
Phase II, where the enzyme attaches a chemical group to the -OH group on the drug
The important enzymes here are transferases, enzymes which conjugate the drug with a chemical group
Commonly conjugated chemical groups are glucuronic acid, sulphuric acid, glycine, glutathione, acetyl and methyl
Biotransformation increases water solubility of the drug, making it easier to excrete, and it (most frequently) inactivates the drug.
There are 4 possible outcomes of a biotransformation reaction:
The active parent drug is converted into an inactive metabolite (most common)
The inactive parent drug is converted into an active metabolite. This is what occurs when you give a prodrug
The active parent drug is converted into an active metabolite
The parent drug is converted into a toxic metabolite
Biotransformation of paracetamol produces a toxic metabolite called NAPBQI. In paracetamol overdose this metabolite accumulates, causing liver necrosis
Treatment for this is acetylcysteine
Neonates have decreased UGT activity, decreasing their elimination of chloramphenicol
Neonates have decreased CYP450 activity. CYP450 and UGT metabolizes diazepam, so they have decreased elimination of it
Neonates have decreased ADH activity, reducing their elimination of alcohol
There are large genetic differences in biotransformation (pharmacogenetics)
Many Scandinavians are so-called slow acetylators and have reduced elimination of drugs which must be acetylated, like isoniazid
CYP450 enzymes can be induced or inhibited
Induction is usually due to drugs binding to a receptor which increases the transcription of the enzyme
Inhibition is usually competitive
Inhibition can be exploited clinically
Ritonavir is a CYP3A4 inhibitor, and is often given with other antiretrovirals which are metabolized by CYP3A4
Ketoconazole is also a CYP3A4 inhibitor, and is often given with cyclosporin, which is metabolized by CYP3A4
There are three ways drugs can be eliminated from the body:
The drug can be biotransformed into an inactive metabolite, which is then excreted via feces or urine
The drug is excreted without being biotransformed
Some of the drug is biotransformed, so both the unchanged drug and inactive metabolites are excreted
We've already encountered biotransformation in biochemistry 2. During biotransformation a drug is converted into one or more metabolites by enzymes. These metabolites may undergo further biotransformation.
The drug that was administered and which has not been biotransformed yet is called the parent compound (because it is the "parent" of the metabolites).
Biotransformation predominantly occurs in the liver, but also in the intestinal mucosa, renal tubular cells and in the colon by bacteria. We'll mostly cover the liver here.
The ultimate goal of biotransformation is to attach a chemical group to the drug molecule. By doing this will the biological activity of the drug be inhibited, and it becomes more water-soluble, which makes it easier to excrete. However, the liver can't just attach any chemical group to any drug molecule. That's not how chemistry works.
For the liver to attach a chemical group to the drug molecule it must first create an -OH group on the molecule that it can attach the chemical group to. This is the phase I reaction of biotransformation.
Now that the drug has an -OH group the liver will attach a chemical group to the -OH group. These chemical groups can be glucuronic acid, sulfuric acid, glycine and so on. The drug is now no longer the same as it was when it was administered – it is now a metabolite.
Typical mechanisms of biotransformation. The "R" here signifies the drug molecule itself.
Let's look at these two in more detail.
For the liver to create an -OH group on the drug the liver must perform one of these three reactions on the drug:
Oxidation (most frequent)
The drug now went from being R-H or something similar to becoming R-OH. It is now a phase I metabolite, which has slightly higher water-solubility but typically the same biological activity, so the liver must still perform phase II.
Note that other groups than -OH can be used as well, such as -NH2, -SH and -COOH, however I'll continue to use -OH as an example because it's the most frequent type.
Oxidation:
The cytochrome P450 superfamily is essential for phase I. CYP450 is a superfamily of enzymes that mostly catalyse oxidation but can perform dehydrogenation and reduction as well. CYP450 is found both in the liver and in the intestinal mucosa. The superfamily is classified into families, which are denoted by number, which are further divided into subfamilies, denoted by capital letters, which contains the individual enzymes, which again are numbered.
So, CYP3A4 is the 4th enzyme of the A subfamily of the 3rd family of CYP450 enzymes. CYP3A4 is also the most abundant CYP enzyme, both in the liver and the intestinal mucosa.
Why are CYP450 enzymes in the intestinal mucosa? Because the intestinal mucosa is the first organ any ingested drug or toxic substance meets. For the body, the earlier biotransformation begins, the better.
Flavin-containing monooxygenase (FMO) is another ER-bound enzyme involved in phase I. It catalyses monooxygenation like the name suggests, where 1 atom from O2 is inserted into the drug to give an -OH group. Like the name suggests does it contain a flavin-group, which comes from riboflavin, vitamin B2.
Some other enzymes that catalyse oxidation aren't found in the ER, so they're non-microsomal. They are:
Monoamine oxidase (MAO) – in the mitochondria
Aldehyde oxidase (AOX) – in the cytosol
Xanthine oxidase (XO) – in the cytosol
Alcohol dehydrogenase (ADH) – in the cytosol
Aldehyde dehydrogenase (ALDH) – in the cytosol
Reduction:
Reduction is catalysed by different enzymes, like:
Microbial enzymes produced by bacteria in the colon
Aldo-keto reductase (AKR)
Carbonyl reductase (CBR)
Methionine sulfoxide reductase (MSR)
Hydrolysis is catalysed by other enzymes however I'm not going to list them as I don't believe it's important.
Now that the drug has an -OH group other enzymes can catalyse the conjugation (attachment) of certain chemical groups to this -OH group, which will make the drug more water soluble and less biologically active.
The enzymes that catalyse phase II are called transferases, because they transfer chemical groups from endogenous cosubstrates onto the drugs. What chemical groups can be transferred? These are the most common:
Acetyl
Methyl
Which chemical group is transferred depends on the drug. For example is morphine always glucuronidated, L-DOPA always methylated and minoxidil always sulphated.
The most important phase II enzymes are UDP-glucuronosyl
transferases (UGT) and N-acetyltransferases (NAT).
Now that the drug has been conjugated with a chemical group is it now:
More water soluble, making it easier to excrete
Less biologically active (in most cases)
Why only in most cases?
There are four possible outcomes of biotransformation of a drug molecule:
Scenario 1 is the most typical. After conjugation the drug becomes inactive, which is what the body tries to achieve by biotransformation. This is what occurs with propranolol, theophylline, paracetamol and so on.
Scenario 2 is what occurs when you give a prodrug. A prodrug is a drug that isn't active in the body by itself. However, after being biotransformed it will become an active metabolite which has effect on the body.
In some cases it turned out that certain drugs that had been available for a long time were actually prodrugs. In other cases are drugs specifically designed to be prodrugs. If the active drug has low oral bioavailability or low water solubility for example can we sometimes produce a prodrug that don't have these drawbacks, and the body will convert the prodrug into the active drug by itself.
Scenario 3 is rarer. In these cases are not only the parent drugs active, but their metabolites also, which slows down the elimination of the drug. This includes drugs like codeine (which is converted to morphine by the liver, which is also active), diazepam and morphine itself. So codeine is converted into morphine which is converted into morphine 6-glucuronide, and all three are active!
Scenario 4 is when a drug is converted into a toxic metabolite. This is usually not a problem, because the body can usually deal with the toxic metabolite before it accumulates. However, this has consequences in overdosing. Let's look at an example.
Paracetamol can be bought without a prescription, so it's not thought of as dangerous. Paracetamol in the liver can be biotransformed by two pathways. It can either:
Be dehydrogenated by CYP2E1 into a toxic metabolite called NAPBQI
Be glucuronidated by UGT into paracetamol-glucuronidate.
Paracetamol-glucuronidate isn't toxic and is excreted without problem. NAPBQI however, is toxic, as it binds to proteins and enzymes and inactivates them. In a healthy liver will some amounts of both metabolites be produced, however NAPBQI is quickly detoxified by conjugation with glutathione, forming a non-toxic metabolite that is excreted without any problem.
If someone overdoses on paracetamol (which is 12g for healthy people) will glutathione stores in the liver be consumed and depleted, so that the liver can no longer detoxify NAPBQI, causing it to accumulate and cause liver necrosis!
This is also significant for alcoholics, for two reasons: The CYP2E1 enzyme is upregulated in alcoholics, because CYP2E1 also inactivates ethanol. Also, the livers of alcoholics have decreased amount of glutathione
Because they have more CYP2E1 enzyme more paracetamol is converted into NAPBQI and less is inactivated by glucuronidation. Also, because they have less glutathione they run out of it more quickly. These factors result in that chronic alcoholics can only tolerate 4-5 grams of paracetamol, which is almost 1/3 of what healthy people can tolerate!
The antidote for paracetamol overdose is N-acetylcysteine, because the liver converts it to cysteine which is an important part of glutathione. This replenishes the glutathione stores.
Biotransformation of paracetamol (=acetaminophen)
In neonates:
Neonates are unfortunate. Their biotransformation enzymes aren't fully mature and active yet, so they are prone to some unfortunate conditions. Here are some examples:
The enzyme that conjugates bilirubin, UGT, is under-expressed in neonates. This means that they are prone to physiological jaundice because the body can't excrete bilirubin normally yet. This is harmless.
UGT also inactivates chloramphenicol. This is the reason chloramphenicol can't be used in neonates, because the impaired biotransformation of it will cause grey baby syndrome
In addition to under-expressed UGT don't neonates have fully expressed CYP450 enzymes either. Both enzymes are needed to biotransform diazepam. The inability to get rid of diazepam is what causes floppy infant syndrome in babies whose mother received diazepam before delivery
Neonates don't have much alcohol dehydrogenase (ADH) either. If the mother had ethanol in their system before the delivery will the baby be born with significant blood ethanol concentration. Neonates need a lot of time to get rid of this ethanol with the low amounts of ADH they have.
Genetics also play a role here. Genetic mutations in biotransformation enzymes can cause people to biotransform certain drugs either too slowly or too quickly. This is called pharmacogenetics and has its own topic in pharma 3. Let's look at some examples.
> 70% of Scandinavians and middle eastern people have deficiency of an enzyme called NAT2. This enzyme acetylates and inactivates certain drugs, especially isoniazid, an anti-tuberculotic drug. These people are called slow acetylators. People with this deficiency have 3 times decreased elimination of the drug compared to normal people. This may increase the risk of toxic effects
CYP2C9 is an enzyme that around 1% of the population lacks. This causes them to have decreased elimination of drugs like diazepam, making sedation last longer.
CYP2D6 is an enzyme that 5-10% of the population has too much of, instead of too little. This makes them ultrarapid metabolizers, meaning that they may be non-reactive to drugs that are metabolised by this enzyme, like certain antidepressants and betablockers.
Induction and inhibition of CYP450 enzymes:
Biotransformation enzymes are just like any other enzyme – they may be induced or inhibited. Induction is usually done by increasing gene transcription, while inhibition is usually competitive.
Drugs induce CYP enzymes by binding to receptors that increases gene transcription of the enzyme.
Here is a table of some examples so you understand what I'm talking about:
CYP family Drug substrates Inducer chemicals Inducer receptor Inhibitor
CYP1 Caffeine, theophylline, paracetamol Drug: Omeprazole
Other chemicals: PAHs (found in smoke) AHR Ciprofloxacin, acyclovir
CYP2 Ketamine, warfarin, diazepam, propranolol, codeine Phenobarbital, rifampin, ethanol CAR Clopidogrel, omeprazole, cimetidine
CYP3 Benzodiazepams, HIV antivirals (amprenavir), cyclosporin, testosterone Rifampin, phenobarbital, spironolactone PXR Macrolide antibiotics, ketoconazole, bergamottin (from grapefruit), azole antifungals, ritonavir
I don't expect you to know this table, however it makes it easier to come up with examples.
Say you give a patient the protein pump inhibitor omeprazole. Omeprazole will bind to the AHR receptor and increase transcription of enzymes in the CYP1 family. This includes both theophylline and paracetamol, among many others. So, if a patient receives both omeprazole and theophylline the effect of theophylline will be decreased, because the patient has upregulated CYP1 enzymes.
Omeprazole is also an inhibitor of CYP2, so if you gave the same patient warfarin would they be at risk of bleeding out because the levels of warfarin in their blood will be higher than normal.
This table also explains the weird fact of how you shouldn't take your medication with grapefruit juice. The fruit contains bergamottin, which is an inhibitor of CYP3. Grapefruit juice could therefore increase the effect of drugs that are normally biotransformed by CYP3.
This induction and inhibition may be exploited clinically. Ritonavir and amprenavir are both HIV antivirals, but ritonavir is also an inhibitor of CYP3, which biotransforms amprenavir. By giving both at the same time can we ensure not only increased effectiveness by giving two synergic drugs, but also because ritonavir decreases the elimination of amprenavir.
The same is exploited with ketoconazole, an antifungal, and cyclosporin, an immunosuppressor. Ketoconazole inhibits CYP3 which biotransforms cyclosporin, which means that we can give smaller amounts of cyclosporin to the patient with the same effect. As a bonus ketoconazole prevents fungal infections in the immunocompromised patient.
7. Distribution of drugs
9. Excretion of drugs
2 thoughts on "8. Biotransformation of drugs"
On this statement "Drugs induce CYP enzymes by binding to receptors that increases gene transcription of the drug." Shouldn't CYP enzyme inducers increase the gene transcription of more enzymes??
Yes, small brain fart there. fixed now. thanks.


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Maserati GranTurismo — сімейство люксових спортивних купе класу Гран-турізмо, що вироблялися компанією Maserati з 2007 по 2019 рік.

Всього було вироблено 28 805 GranTurismos та 11 715 GranCabrio.

Восени 2022 року дебютувало друге покоління моделі.

Перше покоління (Tipo M145, 2007–2019)

Громадськості GranTurismo було представлено в березні 2007 року на Женевському автосалоні.

Двигун Ferrari F136 U V8 об'ємом 4,2 літра розвиває потужність 298 кВт. Співвідношення маса/потужність у GranTurismo дорівнює 4,6 кг/к.с. Автомобіль оснащується 6-ступінчастою автоматичною коробкою передач ZF. Довга колісна база і короткі звіси забезпечують досить просторий внутрішній простір для чотирьох чоловік.

Платформа для GranTurismo була запозичена від Quattroporte з невеликими змінами. Зокрема, скоротили на 125 мм колісну базу, трохи коротшим став задній звис, а сам дводверний кузов став на 30% жорсткішим. Силовий агрегат був зміщений назад завдяки чому компоновка по осях вийшла майже ідеальною - 49:51.

Розганяється купе гранично рівно. Від можливої пробуксовки рятує самоблокований диференціал: при розгоні він блокується на 25%, а при гальмуванні двигуном - на 45%, що запобігає ранньому зриву в занос при скиданні газу в повороті.

З літа 2008 року Maserati також випускає S-версію GranTurismo з двигуном Ferrari F136 Y V8 об'ємом 4,7 літра розвиває потужність 323 кВт. Версія кабріолет представлена в 2009 році на Франкфуртському автосалоні під назвою Maserati GranCabrio, серійне виробництво почалося в 2010 році.

Список стандартних комплектуючих до Maserati GranTurismo досить значний і включає в себе антиблокувальну систему гальм, систему контролю тяги, систему електронного регулювання гальмівного зусилля, систему динамічної стабілізації і екстреного гальмування, імобілайзер, охоронну сигналізацію, центральний замок, аудіосистему Hi-Fi з 8 динаміками, CD-плеєр, автомобільний комп'ютер, Bluetooth, гніздо для зовнішнього аудіоплеєра, багатофункціональну систему рульового управління з підрульовими пелюстками, навігацію, мультифункціональний дисплей, функцію МР3, датчики дощу та освітленості, затемнення заднього внутрішнього дзеркала, сервокермо, задні паркувальні датчики, підігрів передніх бокових дзеркал, роздільний клімат-контроль, круїз-контроль, передні склопідйомники, електрорегулювання водійського і пасажирського крісел, шкіряну оббивку керма, біксенонові фари, омивачі передніх фар, протитуманні фари, задні світлодіодні ліхтарі, систему адаптивного освітлення, подушку безпеки водія і переднього пасажира, передні бічні подушки безпеки і систему натягувачів ременів безпеки.

Технічні характеристики
Двигуни V8 сімейства Ferrari/Maserati F136 V8.

Друге покоління (Tipo M189, з 2023)
5 жовтня 2022 році дебютувало друге покоління GranTurismo (M189). Автомобіль збудовано на платформі FCA Giorgio.

Крім звичайних моделей доступна і повністю електрична модель GranTurismo Folgore EV з трьома електродвигунами сумарною потужністю 761 к.с., розгін від 0 до 100 км/год займає 2,7 с.
Акумуляторна батарея ємністю 105 кВт∙год дозволить проїхати понад 550 км без підзарядки.

В продаж автомобіль надійде в січні 2023 року.

Двигуни
3.0 л Nettuno 90° twin-turbo V6 490 к.с. при 6500 об/хв, 600 Нм при 3000 об/хв (Modena)
3.0 л Nettuno 90° twin-turbo V6 550 к.с. при 6500 об/хв, 650 Нм при 3000 об/хв (Trofeo)
три електродвигуни 761 к.с. 1350 Нм (Folgore)

Примітки

Посилання

Автомобілі Maserati
Автомобілі 2000-х
Автомобілі 2010-х
Гран-турізмо
Купе

redpajama_set_name: RedPajamaWikipedia


Access to the Support System is available 24hrs a day to log new support tickets, monitor support progress, view websites, domain name details and is available to both individuals, companies & businesses alike.
Smile Tech clients are provided with a username and password for thier personal support system.
If you have not received your codes or are a new customer please contact our offices via email at contact@smiletech.gr, via phone or in person (go to contact details >>).


Working with a high value crop, you need a tractor that is exceptionally compact yet powerful and the new MF 3700 is designed for ultimate efficiency and low cost of operation using a range of the latest straightforward and dependable technologies. Efficient drive-lines, advanced compliance with the Stage 3B emissions standard, low fuel consumption, long service intervals, impressive traction and lifting capacities together with low maintenance costs – the MF 3700 simply makes your farming business more profitable. And increasingly so with every hectare that you work.


text:
Tag Archives: Mammoth Lakes
Community News, Local News
Mammoth Mtn Owner Buys Bear Mountain and Snow Summit
September 25, 2014 Gary Young
Mammoth Resorts to Acquire Bear Mountain and Snow Summit Ski Resorts in Southern California
Launching new joint pass product, Cali4nia Pass to offer unrestricted access to all four California mountains —
Mammoth Mountain Ski Area, Bear Mountain, June Mountain and Snow Summit Mountain Resort.
MAMMOTH LAKES, CA September 24, 2014 —
Mammoth Mountain Ski Area, owner of Mammoth Mountain and June Mountain, announced today that it has entered into an agreement to acquire Big Bear Mountain Resorts in Big Bear Lake, California.
Big Bear Mountain Resorts includes both Bear Mountain and Snow Summit, the largest and most popular of southern California's ski and snowboard resorts that host nearly 800,000 winter visits annually.
The combination of these four iconic California mountain resorts creates diverse and unique offerings of both summer and winter experiences for day trips, weekend getaways and extended vacations. Bear Mountain and Snow Summit, located a short drive from everywhere in southern California, with their full complement of outdoor activities from action sports to first-time family experiences, provide an excellent fit with the world class, big-mountain destination experience offered at Mammoth.
"We couldn't be more excited to enter into this agreement with Big Bear Mountain Resorts. These two uniquely southern California resorts have been providing great skiing, riding and biking experiences to
visitors from California and beyond. Millions have enjoyed their first mountain resort experience on the slopes of Bear Mountain and Snow Summit, and we look forward to expanding upon the legacy that
Dick Kun and his people have created over the past six decades," said Rusty Gregory, Chairman and CEO of Mammoth Mountain.
"This acquisition represents the beginning of a renaissance for both
Mammoth and Big Bear and is the first step in the next era of skiing and riding in California. In the coming months we will be announcing exciting new development and expansion plans for each of our four resorts designed to attract visitors from down the street, across the country, and around the world," added Gregory.
To celebrate the occasion, Mammoth has announced a new season pass that includes unrestricted access to all four mountains at the discounted rate of $689 for adults. The new Cali4nia Pass will go on
sale at the Hot Dawgz and Hand Rails event at Bear Mountain this Saturday, September 27 and will then be available online for a limited time only at www.snowsummit.com or www.Cali4niaPass.com.
"The Cali4nia Pass will cut through the clutter in the market by providing the most diverse set of resort options available in California by allowing you to ski where you want, when you want and as often as you want," said Gregory.
This transaction will create one of the nation's largest ski companies with over 2 million visitors per year. Dick Kun, the driving force behind skiing and riding in the Big Bear region and long-time CEO of Big Bear Mountain Resorts commented, "Mammoth has always been the natural long-term fit for the Big Bear
family and we are thrilled to enter this agreement. I am deeply grateful to the employees, shareholders, and the Big Bear community for their work and support during the 63 years of our operations. Mammoth's experience and leadership will ensure that southern Californians will continue to enjoy recreating in the local mountains and will undoubtedly bring in a new era of experiences and opportunities for all of our constituents," continued Kun.
Houlihan Lokey served as exclusive financial advisor to Big Bear Mountain Resorts and assisted in initiating, structuring and negotiating the transaction on its behalf.
Closing is subject to certain conditions, including Big Bear Mountain Resort shareholder approval and transfer of the U.S. Forest Service Permit that permits operations on nearly 1,500 acres of the San
Bernardino National Forest.
About Mammoth Mountain
Mammoth Mountain Ski Area is the leading four-season mountain resort in California. With 1.3-1.5 million annual skier visits, Mammoth Mountain is the third most frequented ski resort in the United States. With longstanding commitment to athletic excellence and innovative alpine, freestyle and nordic terrain, Mammoth is proud to be an official USSA training facility. The company owns and operates a variety of resort businesses including recreation,
hospitality, real estate development, food and beverage and retail. Specific businesses owned and operated by Mammoth Mountain include Mammoth Mountain Ski Area, June Mountain, Tamarack Lodge and Resort, Mammoth Snowmobile Adventures, Mammoth Mountain Bike Park and the Mammoth Mountain Inn. Mammoth Mountain also operates Juniper Springs Resort, the Village Lodge and Sierra Star Golf Course in Mammoth Lakes, California. For
more information on Mammoth Mountain, visit MammothMountain.com or call 800.MAMMOTH.
About BBMR – Real Snow. Real Close. Real Deal.
Big Bear Mountain Resorts (BBMR) includes Snow Summit and Bear Mountain, plus Bear Mountain Golf Course and Snow Summit Summer. Together, BBMR has the region's most progressive terrain parks, most dependable snow conditions, the largest full-service learning programs and a multitude of premier services – just a tank of gas away round-trip from most areas in Southern California. For more information, please visit www.bigbearmountainresorts.com. BBMR is an equal opportunity service provider operating under a San Bernardino National Forest special use permit.
http://www.kibskbov.com/mammothbuysbigbear/
Mammoth Mountain Ski Area / Ski / Snowboard / Resorts / Snow / Mammoth Mountain / June Mountain / Big Bear Lake / Mammoth Lakes / California Mountains / Bear Mountain / Snow Summit
AgreementBear MountainBig Bear LakeCali4nia PassCaliforniaCalifornia MountainsJune MountainMammoth LakesMammoth MountainMammoth Mountain Ski AreaOwnerResortsSeasonSkiSnowSnow SummitSnowboard
Mammoth Community Water District: Update on Conservation Efforts
MCWD UPDATE ON CONSERVATION EFFORTS AND WATER SUPPLY
Water demand drops 25% in August and groundwater pumping supplies almost 75% of MCWD water supply during this year's drought.
Mammoth Lakes, CA – Last month, Mammoth Community Water District customers made a significant effort to conserve water, and as a result, water demand dropped 25% from previous years. This conservation effort from our customers contributes directly to maintaining a reliable water supply during the extended drought. Our water supply consists of a mix of surface water and groundwater, and recycled water is used for golf-course irrigation. With severely drought-limited surface water supplies this year, our groundwater supply has been essential to meet customer's needs. Groundwater production has supplied almost 75% of our water supply during peak demand this summer, from 53% in June to 74% in July and August. Contributions from surface water and recycled water contributed 18% and 8% respectively.
Heavy reliance on groundwater pumping has stressed our wells and resulted in reducing the production capacity of two of our nine production wells. The largest user of water, outdoor irrigation demand, is expected to decrease in September as the days shorten and cooler temperatures return. We would like to thank our customers for the significant saving in water to date and request that conservation efforts continue. Level 1 water restrictions are still in effect:
· Even numbered addresses irrigate on Monday, Wednesday and Saturday
· Odd numbered addresses irrigate on Tuesday, Thursday and Sunday
· No irrigation between 10:00 am and 7:00 pm
· A hose must be equipped with an automatic shut-off nozzle
· No washing of hard surfaces is allowed unless for safety or health reasons
· Leaks must be repaired within five days after notification from the MCWD
This year's drought and heavy reliance on pumping underscores the importance of protecting our groundwater resources from potential adverse impacts of increased geothermal production by Ormat near our well locations. These adverse impacts include polluting the groundwater and reducing the supply. The MCWD remains committed to pursuing a monitoring and mitigation plan for the geothermal plant expansion that protects our water resources and ensures the continued availability of a reliable water supply.
About Mammoth Community Water District
MCWD provides water and wastewater utility service to the Town of Mammoth Lakes and surrounding areas. MCWD strives to provide reliable, affordable utility service to our customers and to conduct our operations in a manner reflecting our stewardship role. We encourage our customers to practice responsible use of our limited water resources, and to take advantage of the information and services available to support this goal.
http://www.kibskbov.com/mammothcommunitywaterdistrict/
Mammoth Lakes / California / Drought / Water / Conservation / Efforts / Projects / Mono County / Water Supply / Update
CommunityConservationEffortsMammoth LakesMono CountyProjectsUpdateWater Supply
Community Flu Clinics 2014
September 9, 2014 Gary Young
MONO COUNTY HEALTH DEPARTMENT PRESENTS COMMUNITY FLU CLINICS 2014
Date Location Day/Time
09.29.14 Lee Vining Community Center Monday 4:00-6:30 PM
10.07.14 Walker Senior Center Tuesday 1:00 – 3:00 PM
10.08.14 Bridgeport Health Department Wednesday 1:00-3:30 PM
10.09.14 June Lake Community Center Thursday 5:00-6:30 PM
10.15.14 Paradise Fire Station Wednesday 4:30-5:45 PM
10.15.14 Swall Fire Station Wednesday 6:15-7:15 PM
10.16.14 Chalfant Community Center Thursday 5:00 – 6:00 PM
10.16.14 Benton Community Center Thursday 6:30-7:30 PM
10.20.14 Mammoth Lakes Elem. School Monday 4:00 – 7:00 PM
10.23.14 Crowley Lake Community Center Thursday 4:00 – 7:00 PM
Flu vaccine is now recommended for everyone over the age of six months.
FluMist® nasal spray is available for healthy, non-pregnant 2-49 year olds.
The pneumococcal vaccine is also available. Free with Medicare Part B card present; otherwise $78.00.
Pneumococcal not available at Lee Vining Community Flu Clinic.
Cost for Flu vaccine:
$10 for adults (19 yrs and older)
$5 for children (6mo -18 yrs)
Medicare Part B free with card present.
Additional Clinics:
10.27.14 Mammoth Health Department Monday 10:00 AM-12:00 PM, by appt
10.30.14 Mammoth Health Department Thursday 8:30-11:00 AM, by appt
11.04.14 Mammoth Health Department Tuesday 4:30-6:30 PM, drop-in
11.12.14 Mammoth Health Department Wednesday 4:30-6:30, drop-in
Children may also receive flu vaccine at school clinics to be held this Fall.
http://www.kibskbov.com/communityfluclinics/
Mono County Health Department / Community Flu Clinics / 2014 / Vaccinations / Mammoth Lakes / Lee Vining / Bridgeport / Walker / Prevention / Crowley / June Lake / Fall / Vaccines / Eastern Sierra
BridgeportCommunityCrowley LakeEastern SierraFlu ClinicsJune LakeLee ViningMammoth LakesMono CountyMono County Health DepartmentPreventionVaccinationsWalker
Deceased Man Found, Mammoth Lakes, CA
DECEASED MAN FOUND BEHIND MAMMOTH LAKES RESIDENCE
On Monday, September 1, 2014 at approximately 6:10 a.m., Mammoth Lakes Police Officers were called in from home to respond to a partially clothed, unresponsive individual behind a residence at Pinecrest Ave in Mammoth Lakes. Upon arrival, officers found a white male, about 30 years of age and quickly determined he was deceased. There was evidence of damage to the remains consistent with animal activity. The cause of death will be determined by an autopsy to be conducted by the Orange County Coroner's Office. Although the cause of death is unknown at this time, evidence at the scene indicated that death occurred prior to contact with any wildlife. Personnel from the California Department of Fish and Game and the Mammoth Lakes Wildlife Specialist responded to the scene and do not believe the wildlife involved pose any reason for concern in the community.
The victim has not been positively identified, but it is believed he is an individual that had contact with several local agencies in the preceding 24 hours. On Sunday, August 31 at approximately 3:30 p.m., a Mono County Sheriff's Deputy contacted a pedestrian matching the description of the deceased north of Bridgeport. The individual was transported by a Mono County Paramedic unit to Mammoth Hospital where he was evaluated by medical staff and Mono County Behavioral Health. While at the hospital, the individual became agitated and uncooperative resulting in a request for a law enforcement response. Officers from the Mammoth Lakes Police Department and the California Highway Patrol responded and assisted in restraining the individual. The individual subsequently left the hospital voluntarily, refusing care. Because of privacy laws, the results of his evaluation cannot be released.
At approximately 1:30 a.m., Mammoth Lakes Police Officers responded to a call from the Sierra Lodge about a man in the parking lot hitting himself in the head with a fire extinguisher taken from the hotel. Officers responded and found the fire extinguisher, but the individual was gone. Surveillance video from the hotel was reviewed and it was determined that it was likely the same individual who was previously at the hospital.
The Mammoth Lakes Police Department is conducting a death investigation related to the circumstances surrounding the death. The Mono County Sheriff/Coroner's Office is coordinating the autopsy which will determine the cause of death. Anyone having information is encouraged to contact the Mammoth Lakes Police Department at (760) 934-2011.
http://www.kibskbov.com/deceased-man-found-mammoth/
Mammoth Lakes Police Department / Mammoth Lakes / Eastern Sierra / Bishop / News Release / Deceased / Mono County Sheriff's Office / Mammoth Lakes Police Officers
BishopEastern SierraMammoth LakesMammoth Lakes Police DepartmentMammoth Lakes Police OfficersNews Release
All Things Adorable
Baby Bums and Butterfly Wings Make a Happier Wednesday for All!
August 27, 2014 Gary Young
It's the Final Stretch of Wednesday's Workday, & Baby Isla is Now ONE…
It's 4 o'clock at the office. Morning coffee has officially worn off. Your lunch hour has come and gone. And, it's not quite time for dinner.
Let us help you push through…
Happiest First Birthday to Isla!
Isla Turns 1 – Mammoth Lakes, CA
#IslaTurns1
It's not easy turning one in Mammoth Lakes, California…
Baby bums and butterfly wings from our Wednesday to yours.
Thanks for sharing, Hanna & Silas.
Happiest Birthday, Isla Linda!
#teamKIBS
http://www.kibskbov.com/happywednesday/
Bishop / Mammoth Lakes / Eastern Sierra / Birthday / Baby / All Things Adorable / Happy / Wednesday
All Things AdorableBabyBirthdayBishopEastern SierraHappyMammoth LakesWednesday
SAR Aids Injured Hiker at Arrowhead Lake, Mammoth
Search and Rescue Team Responds to Injured hiker at Arrowhead Lake
RE: Search and Rescue Team Operation: Aid to an injured hiker at Arrowhead Lake
On the afternoon of Thursday, August 14th, 2014, at approximately 2:00pm, Mono County Sheriff's Dispatch received a call regarding an injured hiker at Arrowhead Lake.
SAR Operation at Arrowhead Lake, Mammoth
A 32-year old female hiked to Arrowhead Lake were she sustained a leg fracture by striking a tree while swinging from a rope over the lake. Due to her leg fracture, she was unable to hike out. The Mono County Sheriff's Search and Rescue (SAR) team was called to aid the injured hiker.
Members from the SAR team, and personnel from Mono County Paramedics and the Mammoth Lakes Fire Department, hiked to her location, stabilized the fracture and transported her one and a half miles, using a wheeled litter, to the ambulance at the trailhead. The rescuers were also assisted in the carryout by a group of cross-country runners from California State University San Marcos. The injured hiker was transported via ambulance to Mammoth Hospital for further treatment.
http://www.kibskbov.com/injuredhikeratarrowheadlake/
Eastern Sierra / Mammoth / Search and Rescue Team / SAR Operation / Injured Hiker / Arrowhead Lake / Mono County Sheriff's Department / Responds
AidsArrowhead LakeEastern SierraInjured HikerMammothMammoth LakesMono CountyMono County Sheriff's DepartmentOperationRespondsSARSearch and Rescue Team OperationTeam
KIBS/KBOV Announcements
CARL'S JR. BISHOP SUPPORTS BRONCO SPORTS
Local Carl's Jr. Supports Our Community's Youth
KIBS/KBOV Radio is proud to introduce our local Carl's Jr. as Arnie Palu's Saturday Sports Roundup Heritage Sponsor.
Carl's Jr. Coupons for Bishop, Mammoth Lakes, & Lone Pine – Print or Show a Carl's Jr. Coupon on Your Mobile Device to SAVE, Now
COUPONS, HERE.
Carl's Jr. – Bishop
768 N. Main St. Bishop, CA 93514
Hours: 6:30 AM – 12:00 AM
SUPPORTING OUR COMMUNITY'S STUDENT ATHLETES
Carl's Jr. Bishop is a proud Heritage Sponsor of the Bishop Broncos. Carl's Jr.'s Bishop Location supports the local high school sports of our community, loyally— and year round. GO BLUE.
FELLOW BISHOP BRONCO FANS?
Students, neighbors and fellow Bronco fans, click here for coupons to redeem at Carl's Jr. in Bishop. Great deals and low prices are here waiting for you. Save a buck! And, treat yourself to featured monthly specials.
And, try it all at half price!
COST CUTTERS 50 % OFF FROM KIBS/KBOV:
FIND GREAT HALF PRICE OPPORTUNITIES TO GREAT BUSINESSES ALL OVER THE EASTERN SIERRA AND WEST CENTRAL NEVADA, HERE – WITH KIBS/KBOV COST CUTTERS!!
Carl's Jr. – Bishop, Mammoth and Lone Pine: $10.00 Certificate
KIBS/KBOV Price: $5.00
Green Burrito – Bishop: $10.00 Certificate
Certificates must be purchased at KIBS/KBOV – S. Highway 395,Bishop, CA at the south end of town, next to Brown's Town and The Bishop Country Club, Mon-Fri, 9 a.m. to 5 p.m. To order by mail, please call our office at (760) 873-6324.
Certificates are limited, so get yours today!
Breakfast, Charbroiled Burgers, Chicken & More, Salads, Sides, Desserts, Shakes & Malts, Beverages, Better-For-You Options, and Green Burrito.
Carl's Jr's Better-For-You Options feature menu items under the following categories:
Low-Carb It, Veg It, Trim It, Turkey Burger, and Gluten Sensitive. Check it out, HERE.
DON'T FORGET ABOUT THE GREEN BURRITO AT CARL'S JR.
Is anyone in the mood for Mexican? Green Burrito Cost Cutters are available for the Bishop location with KIBS/KBOV.
Green Burrito features burritos, tacos, specialties, and side items.
TRY THEIR BURRITOS…
Burrito California, Burrito Mexicano, and Burrito Especial – All available with Chicken or Steak
Bean, Beef & Cheese and the Bean & Cheese Burritos
TACOS, TOO!
Street Tacos, Hard, Soft, and Crispy
PLUS, WAY MORE! CHECK THE GREEN BURRITO MENU, HERE.
Carl's Jr. – Lone Pine
401 N Main St, Lone Pine, CA 93545
www.carlsjr.com
Carl's Jr. – Mammoth Lakes
437 Old Mammoth Rd, Mammoth Lakes, CA 93546
768 N Main St, Bishop, CA 93514
http://www.kibskbov.com/localcarlsjr/
Carl's Jr. Bishop / Bishop Broncos/ Bishop High School Sports/ BUHS Sports / Bishop Bronco Sports Sponsor / Saturday Sports Roundup Sponsor / Carl's Jr. Lone Pine / Carl's Jr. Mammoth Lakes
BishopBronco SportsCarl's JrCommunityEastern SierraLocalLone PineMammoth LakesSponsor


text:
Sajid Javid says it was 'odd' that he was blocked from attending Trump banquet and 'I don't like it'
Donald Trump and Sajid Javid.
Sajid Javid says it was "odd" that he was blocked from attending the recent state banquet with Trump.
The Home Secretary, who is from a Muslim background, was the only senior cabinet minister not to receive an invite.
Javid says he asked Downing Street why he had been blocked and was told that Home Secretaries aren't usually invited.
Muslim groups have accused the UK government of pandering to racism by failing to invite Javid.
Visit Business Insider's home page for more stories.
LONDON - Sajid Javid says he was blocked by Number 10 from attending the recent state banquet with Donald Trump, despite all other senior members of Theresa May's Cabinet being invited.
The Home Secretary, who is from a Muslim background, told the BBC Radio 4 Today programme that he thought it was "odd" that he hadn't been invited despite more junior members of the Cabinet.
"I don't like it for the reason you have just said," Javid told the programme.
"It is odd. My office did ask Number 10 [the prime minister's office] and they said no, so you would have to ask somebody from Number 10 why they made that decision."
Asked whether he believed he was blocked because of his background and Trump's views about Muslims, he replied: "No I'm not saying that at all. I really don't know. I haven't got an answer."
Other senior cabinet ministers present at the banquet with Trump included the Foreign Secretary Jeremy Hunt, the chancellor Philip Hammond, the cabinet office minister David Lidington, the Environment Secretary Michael Gove, the Defence Secretary Penny Mordaunt and the International Trade Secretary Liam Fox.
Last week the Muslim Council wrote to the prime minister, criticising the decision to exclude Javid, who is currently running to replace May as prime minister.
"There are fears that our nation is willing to give up on our principles of fairness and equality for all, in order to placate President Trump, even going so far as to exclude our home secretary solely due to his Muslim heritage," Harun Khan, the secretary general of the MCB, wrote.
Javid had previously criticised the president for appearing to endorse the far-right group Britain First. In 2017, Javid tweeted that "POTUS has endorsed the views of a vile, hate-filled racist organisation that hates me and people like me. He is wrong and I refuse to let it go and say nothing."
However, he is not the only senior Conservative politician to have previously publicly lambasted Trump. When the current frontrunner to become Britain's next prime minister, Boris Johnson, was Mayor of London, he labeled Trump "stupefyingly ignorant" and "unfit to hold the office of President of the United States."
Trump has since gone on to all but endorse Johnson for prime minister.
Our Brexit Insider Facebook group is the best place for up-to-date news and analysis about Britain's departure from the EU, direct from Business Insider's political reporters. Join here.
NOW WATCH: Fox News pundits are using white supremacist language tied to 'The Great Replacement' conspiracy theory
What each 2020 Democratic candidate's walk-out song says about them, according to Pandora's musicologist


text:
Q: How do I read line 3 from the console output in Ruby? I want to read each line at the console and then split them by " ".
The output at the console is:
List of devices attached
0125Mt3B19ct7343    device
07v6584d0a8a6cy7    device

I want to get the Device Ids in an array since I am attaching multiple Android devices to a USB hub.
Here is what I have done so far:
class Init

  $devices = Array.new

  def getDevice

    cmd = "adb devices"
    value = `#{cmd}`
    $deviceCount =  value.lines.count
    puts "#$deviceCount Devices are Connected to the USB Hub"
    puts $deviceCount
..........

  end

The above code is useless as I am unable to get the correct count of the devices connected. I am using lines since I cannot figure out what else I could use.
I want to read the output at the terminal and skip the first line that is " List of devices attached" and then split the following lines which have the Device ids so that I can insert them into an array containing just the device ids.
For instance:
devices[] = {0125Mt3B19ct7343, 07v6584d0a8a6cy7, ... }

A: Here's an untested version of your code, written a bit more idiomatically:
class Devices

  @@devices = []

  def self.get_devices
    @@devices = `adb devices`.split("\n")[1 .. -1]
    device_count = @@devices.size
    puts "#{ device_count } Devices are Connected to the USB Hub"
    puts device_count
  end
end

devices = Devices::get_devices

Things to pay attention to:

*

*Don't name a class "Init". A class should be a thing, not an action. I took a liberty and named it "Devices", which really isn't correct, because a class should be a single thing, but in this case you're looking for a list of devices. DeviceList might be a better name.

*$devices... um... is totally wrong. Don't use a global until you understand what globals are for. Instead, use a class variable, such as @@devices in the case of a class called Devices.

*Array.new is oh-so-pretty, but accomplishes nothing that [] doesn't do for this purpose, so use the shorter, and more concise [].

*def getDevice - don't use camelCase for Ruby methods. By convention methods and variables are snake_case, and Classes and Modules are camelCase. Follow the convention if you intend to ever publish your code or get a job programming Ruby or Rails.

*split("\n")[1 .. -1] splits the output received from `adb devices` into separate lines and returns the second to the last lines. That means you get instant removal of the "List of devices attached" line returned.

Devising these sort of interfaces is always a learning experience. You probably want to be able to get the current list of devices at the last poll, plus have another method that gets the current devices now and update the variable for the last-seen devices:
class DeviceList

  @@devices = []

  def self.get_devices
    @@devices = `adb devices`.split("\n")[1 .. -1]
  end

  def self.device_list
    get_devices() if @@devices.empty?
    @@devices
  end

end

devices = DeviceList::get_device_list

device_count = devices.size
puts "#{ device_count } Devices are Connected to the USB Hub"
puts device_count

This lets you request the current list using Devices::device_list or force a new (re)load of the list using Devices::get_devices. Note also, that this removes the output and counting of the size of the returned list from the class. Those actions can occur in a class, but for this sort of code I'd probably rely on Ruby's ability to print list, and make the class only return the list of devices. YMMV.
There are a lot of smarter people here on Stack Overflow, who can help you with the proper taxonomy for defining names for methods and such.

redpajama_set_name: RedPajamaStackExchange


text:
Young Detective Dee: Rise of the Sea Dragon (2013) Hindi Dubbed
Young Detective Dee: Rise of the Sea Dragon (2013) Hindi Dubbed The action-packed and captivating tale of Dee Renjie's beginnings in the Imperial police force. His very first case, investigating reports of a sea monster terrorizing the town, reveals a sinister conspiracy of treachery and betrayal, leading to the highest reaches of the Imperial family.
Young Detective Dee: Rise of the Sea Dragon (2013) Hindi Dubbed Watch Online Free
Genre: Action, Adventure, Crime, Fantasy, Hollywood Hindi 2013
Director: Hark Tsui
Actors: AngelaBaby, Carina Lau, Chen Kun, Chien Sheng, Kim Bum, Mark Chao, William Feng
Keywords:detective dee rise of the sea dragon rise of the sea dragon full movie rise of the sea dragon full movie download rise of the sea dragon full movie in hindi rise of the sea dragon hindi rise of the sea dragon hindi download rise of the sea dragon hindi dubbed download rise of the sea dragon in hindi rise of the sea dragon movie download rise of the sea dragon tamil dubbud the rise of the sea dragon young detective dee : rise of the sea dragon
doodstream.com
Tai Chi Hero (2012) Hindi Dubbed
Tai Chi Hero (2012) Hindi Dubbed Chinese steampunk martial arts blockbuster about the early years of Tai chi master Yang Luchan, the man who founded in the 19th century what…
Genre: Action, Adventure, Hollywood Hindi 2012
Iron Fan (2018) Hindi Dubbed
Iron Fan (2018) Hindi Dubbed Iron Fan (2018) Hindi Dubbed Watch Online Free
Road to Red (2020) Hindi Dubbed
Road to Red (2020) Hindi Dubbed Watch Online Free A surf-skate action-thriller about five best friends who set out on a road trip that quickly turns into an epic battle…
Country: Portugal, USA
Genre: Action, Adventure, Hollywood Hindi 2020, Horror
Resident Evil: Vendetta (2017) Hindi Dubbed
Resident Evil: Vendetta (2017) Hindi Dubbed BSAA Chris Redfield enlists the help of government agent Leon S. Kennedy and Professor Rebecca Chambers from Alexander Institute of Biotechnology to stop a…
Genre: Action, Adventure, Animation, Hollywood Hindi 2017, Horror, Mystery, Science Fiction
Dark Forces (2020) Hindi Dubbed
Dark Forces (2020) Hindi Dubbed In search of his sister, a renegade criminal seeks answers at a sordid hotel where he encounters a sinister guest and romances a mysterious waitress….
Genre: Action, Hollywood Hindi 2020, Horror, Mystery, Thriller
Hampton's Legion (2021) Hindi Dubbed
Hampton's Legion (2021) Hindi Dubbed When the Confederacy can no longer finance massive armies, Wade Hampton III, using his own money started, financed, and supplied his own infantry, cavalry, and…
Gopi Kishan (1994) Hindi
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Genre: Action, Comedy, Older Movies
Unknown (2011) Hindi Dubbed
Unknown (2011) Hindi Dubbed An American biologist attending a conference in Berlin awakens from a coma after a car accident, only to discover that someone has taken his identity and…
Country: France, Germany, UK, USA
Genre: Action, Hollywood Hindi 2011, Mystery, Thriller
General Commander (2019) English
GRS operative Jake Alexander and his team of young recruits go after the most dangerous and notorious criminals with the help of a Hong Kong billionaire. General Commander (2019) English…
Woman in the Woods (2020) Hindi Dubbed
Woman in the Woods (2020) Hindi Dubbed Fable becomes reality when Jason returns to his father's Homeland of the Philippines after his passing and investigates the stories he grew up…
Genre: Action, Adventure, Fantasy, Hollywood Hindi 2020
The Misadventures of Hedi and Cokeman (2021) Hindi Dubbed
The Misadventures of Hedi and Cokeman (2021) Hindi Dubbed – En Passant Pécho: Les Carottes Sont Cuites (2021) En passant pécho (original title) In Paris, two dysfunctional dealers use family…
David (2013) Hindi
David (2013) Hindi The story is about two Davids living in different parts of India whose lives eventually come together in a twist of events., who are about to take…
Genre: 2013 Movies, Action, Crime, Drama, Romance
Trailer: Young Detective Dee: Rise of the Sea Dragon (2013) Hindi Dubbed


text:
Dries Buytaert
Blog Projects Photos About
Section 230: repeal, reform or reprioritize?
Today, the U.S. Congress and big tech companies continued the debate about Section 230 of the 1996 Communications Decency Act.
Put simply, Section 230 provides websites immunity from liability from third-party content. This internet legislation is a double-edged sword. On the one hand it has allowed the dangerous spread of misinformation on social media. On the other hand it has helped the internet thrive.
If I write something untrue and damaging about you on Facebook, you might be able to sue me, but you can't sue Facebook. As a result, social media companies don't really care what is said on their platforms. Their immunity is a big reason why fake news, hate speech and misinformation has been able to spread uncontrollably.
At the same time, Section 230 makes it possible for bloggers to host comments from their readers, for Open Source communities to work together online, and for YouTubers to share videos. Section 230 enables people to share, innovate and collaborate. It has empowered a lot of good.
President Biden has suggested revoking Section 230. Other policy makers would like to reform Section 230. Either revoking or modifying Section 230 could have a big impact on any organization that hosts online content.
Hosting companies could be impacted, but also bloggers and Open Source communities. Having to police all content could quickly become unsustainable, especially for individuals and small organizations. People publish so much new content every day!
As Katie Jordan, the Director of Public Policy and Technology for the Internet Society said, If cloud providers get wrapped up in this conversation about pulling back intermediary liability protection, then by default, they're going to have to reduce privacy and security practices because they'll have to look at the content they're storing for you, to know if they're breaking the law. .
A wholesale repeal of Section 230 seems too far reaching to me. It could cause more harm than good. A careful reform seems more appropriate.
Instead of being so focused on Section 230, I'd start by regulating search and social media algorithms. Hosting content is one thing, but recommending content to millions of people is another. When search and social media companies reach billions of people, their content recommendation algorithms can sway public sentiment, introduce bias or rapidly spread misinformation. We should start there.
I've said in the past that we need an FDA for large-scale algorithms that impact society. Just as the FDA ensures that pharmaceutical companies aren't lying about the claims they make about their drugs, there should be a similar regulator for large-scale software algorithms. For example, we need some level of guarantee that companies like Google, Twitter and Facebook won't intentionally (or unintentionally) manipulate search results to shape the public opinion.
— Dries Buytaert
Dries Buytaert is an Open Source advocate and technology executive. More than 10,000 people are subscribed to his blog. Sign up to have new posts emailed to you or subscribe using RSS. Write to Dries Buytaert at dries@buytaert.net.
Calendar icon March 25, 2021
Clock icon 1 min read time
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Trace Route Trace Route, its a useful utility that traces the route of the information traveling form the host computer to the remote destination. This will allow you to pinpoint where the information is getting stuck or slowing down.
Ping Short for Packet Internet Groper, a utility to determine whether a specific IP address is accessible. It works by sending a packet to the specified address and waiting for a reply. PING is used primarily to troubleshoot Internet connections.
HTTP Server this features allows you to check for the server version of a specific web server, this also returns a HTTP header from the server.
WhoIs An Internet utility that returns information about a domain name or IP address. For example, if you enter a domain name such as NETWorks.com, whois will return the name and address of the domain's owner (in this case, Capturix Software Technologies). This application can make WhoIs for all domains available worldwide.
IP Calculator This calculator will calculate what subnet mask to use to get the required number of networks or nodes.
Connection Spy This utility ables you to debug and watch a connection performed by other programs to a server. A socket bypass that works with any TCP/IP application.


text:
THE BLACK CROWES AND JIMMY PAGE 'LIVE AT THE GREEK' CRASHES SERVER DUE TO OVERWHELMING DEMAND
JIMMY PAGE & THE BLACK CROWES'
"LIVE AT THE GREEK" CD
TEMPORARILY CRASHES MUSICMAKER.COM'S
SERVERS DUE TO OVERWHELMING DEMAND
Musicmaker.com's servers temporarily crashed last night due to unprecedented consumer demand for Jimmy Page & The Black Crowes' "Live At The Greek" CD, released worldwide yesterday on the internet only via Musicmaker.com.
The first day's requests and orders resulted in "Live At The Greek" becoming the largest selling custom CD and paid download in the history of internet music.
Pete Angelus, worldwide manager of The Black Crowes commented that, "We were thrilled by the magical performance given by Jimmy Page and The Black Crowes during the recording of the 'Live at The Greek' CD. The immediacy with which we can get it to the fans via the internet and Musicmaker.com makes this an exciting and unique project. It is inspiring to see the fans take the music business to a new level and rewrite the rules. Their response is amazing."
According to Larry Lieberman, Worldwide Marketing President for Musicmaker.com, "The demand for Jimmy Page & The Black Crowes has exceeded anything we've ever experience before and continues to be significantly beyond our expectations."
The 19 customizable tracks – a mix of newly recorded, classic Led Zeppelin songs and additional vintage blues numbers – were recorded by guitar virtuoso Jimmy Page and The Black Crowes during their sold-out shows at the Greek Theatre in Los Angeles on October 18 and 19, 1999. This historic compilation–featuring over two hours of music–is not available via traditional retail outlets, but is only found exclusively online at Musicmaker.com.
Fans have the ability to choose what quantity, order and format they want to get their favorite Page-Crowes music. Fans can produce their own personalized Page-Crowes disc by buying only the material they want from a selection of 19 songs, encompassing two hours of music, and customizing their running order in a single CD or double CD depending on how much music the fan selects. A single pre-selected 18-track double CD is also available with a full-color, eight-page booklet and liner notes. Finally, fans can sample music and purchase downloads of individual songs directly to their computer.
This entry was posted in Press Releases, The Black Crowes. Bookmark the permalink.


Roland Barthes's packages – in comics?
Speaking of grids: in his book about Japan¹, Empire of Signs (L'Empire des signes, 1970), Roland Barthes doesn't mention manga and their panel grids directly. However, he comes close to it in a chapter titled "Packages": "every [Japanese] object […] seems framed. […] around it, there is: nothing, an empty space […]." (p. 43 in the Hill and Wang translated edition; italics by Barthes). This sounds like comic panels and gutters alright. On the other hand, "this frame is invisible; the Japanese thing is not outlined" (ibid.).
The page background is black, which means that the tiny black strip between the bottom two panels is part of the gutter, not a panel outline.
Still, Barthes is more concerned with traditional Japanese room furnishings, ikebana, and wrapped souvenirs than with comics. The interesting question here is: if the Japanese culture has developed a general fondness for framing, packaging, delimiting things, does this explain why comics with their framed panels have become so popular there? From the way in which Barthes characterises his framed objects, the answer seems to be 'no'. "The [Japanese] thing is […] distinct […] by an excision which removes the flourishing of meaning from the object" (ibid.). Comics work the other way round: by placing a panel into a sequence of other panels, meaning is bestowed on the panel. Thus the gutter between the panels doesn't excise them – on the contrary, it glues them together.
It's curious and regrettable that Barthes doesn't mention manga (or anime, or most other contemporary Japanese pop cultural media for that matter) at all in Empire of Signs. Perhaps, if he had written it 20 years later (if he would have still been alive by then), at the height of the manga boom in Japan, he wouldn't have been able to ignore them.
¹ Barthes makes it clear, though, that his book is not about the 'real' Japan, but rather about a "deliberately formed system" out of "a certain number of isolated features", a "fictive nation" which he chose to call "Japan" (p. 3 in the Hill and Wang translated edition).
Rosalind Krauss's grids – in comics?
The absolute stasis of the grid, its lack of hierarchy, of center, of inflection, emphasizes not only its anti-referential character, but – more importantly – its hostility to narrative. This structure, impervious both to time and to incident, will not permit the projection of language into the domain of the visual, and the result is silence.
That doesn't sound like comics at all, does it? Part of the problem might be, Krauss never defines what she means by "grid". This would have been a good idea though, because even in mathematics there doesn't seem to be a commonly agreed definition.¹ From the examples pictured in her essay, it looks like she means two different types of grid images: one in which a grid is formed by sets of drawn (or painted, etc.) parallel lines (e.g. Agnes Martin's paintings), and another in which these lines are only implicitly formed by the borders of rectangles (e.g. Jasper Johns's Gray Numbers, to which we'll get back later in this post).
More on this layout in a minute.
Once you start paying attention to these things, the variety of Karuho Shiina's layouts is amazing. It would be fun to see how many pages into Kimi ni Todoke a page layout is repeated for the first time, but I'll leave this exercise for another time.
Krauss doesn't expressly distinguish implicit and explicit grids, but she makes another interesting distinction: centrifugal vs. centripetal.³ A centrifugal reading of a work of art assumes that "the grid extends, in all directions, to infinity" (p. 18). The image is "a tiny piece arbitrarily cropped from an infinitely larger fabric", thus "compelling our acknowledgement of a world beyond the frame". A centripetal work of art, on the other hand, is "an autonomous, organic whole" (p. 19).
Perhaps the overall character of this page is still centrifugal, but not quite as much so as in the New Frontier example.
One final remark about the purported "hostility to narrative" of the grid: I think Krauss proves herself wrong by picturing Jasper Johns's Gray Numbers. In this painting, each rectangle of the grid (except for the top left one) is filled with a numeral between 0 and 9. Let's look at a random rectangle, say, the middle one in the bottom row. It's a 4. The rectangle above it is a 3. The one on the left is also a 3. On the right there's a 5, and next to the 5 there's a 6… You get the idea. Obviously, there is a pattern here. From the top left to the bottom right corner, the numerals form a sequence – either horizontally or vertically – in which the number is increased by 1 until it is reset to 0 when it would otherwise reach 10. My point is: it matters little what's inside the rectangles, because we have a tendency to see grids as sequences. And (while the precise meaning may be a matter of debate) a meaningful sequence at that – which amounts to, for all intents and purposes, a narrative. Only completely empty or uniform grids (e.g., again, Agnes Martin's) resist this reading as a narrative.
All that being said, it should be noted that none of it is really the point of Krauss's essays, which are more concerned with the grid as a typical form of modernist painting within the discourse of originality and repetition.
¹ See e.g. the keyword "grid" at Wolfram MathWorld and the article "Regular grid" at Wikipedia.
² The reading order is right to left here, so the 4th panel is the bottom right one and the 5th panel the bottom left one.
³ More precisely, Krauss acknowledges that this discourse predates her essay. She cites John Elderfield, "Grids", Artforum X (May 1972), 52-59.


We invited the Wainhouse Research test team to assess Lifesize® Cloud, our cloud-based video collaboration service offering ad-hoc and scheduled video calling. While Lifesize Cloud is marketed on simplicity, its ability to reach a wide range of participants and easy access, Wainhouse Research aimed their research on the practicality and workflow of the system.
Wainhouse Research pointed out that Lifesize Cloud focuses on what matters most to users, such as making systems easier to install and use by providing a detailed walkthrough of the Lifesize Cloud registration setup. Wainhouse Research also tested how dynamic Lifesize Cloud really is by making multiple connections from several people in different locations, praising how everyone was able to get connected smoothly, with good audio.
Download this guide to learn more about what Wainhouse Research had to say about Lifesize Cloud and Lifesize® Icon™.


text:
Bear Viewers Raise Over $100k for Conservation, After End of the Grizzly Bear Trophy Hunt
Photo by Jeff Reynolds / Maple Leaf Adventures
Dec 18, 2019 – VICTORIA, BC — Although skeptics like to say that travel companies will only take action to protect the planet when mandated by law, the bear viewing industry on Canada's west coast is proving once again they're leaders in sustainable tourism.
This week, British Columbia's Commercial Bear Viewing Association (CVBA), which represents the leading bear-viewing operators in the province, announced that, in the second year since grizzly bear hunting was banned in the province, it has raised more than $114,000 for bear conservation.
The funds come from a conservation surcharge that operators added to their tariffs in 2019. The companies themselves created the idea and voluntarily implemented it.
The amount raised is more than the three times the average contribution that commercial and residential hunting associations previously raised for bear conservation, allaying concerns that the end of the hunt would mean that less money is available for grizzly and black bear science and conservation.
This is just one of many conservation actions that CVBA member companies take every year to protect the wildlife, ecosystems and communities in which they operate.
Maple Leaf Adventures, a coastal expedition cruise company that specializes in bear viewing, is one example. Maple Leaf and several of its colleagues founded the CVBA 18 years ago to develop the industry in a way that protects bears.
Many of the companies are ecotourism companies, run by people who take a holistic and caring approach to their guests and their environment.
"If we don't have a symbiotic relationship with the wildlife we view, then we don't deserve to exist as an industry," says Kevin Smith, CEO of Maple Leaf Adventures and a senior bear viewing guide. "At the CVBA, we've all been bear advocates from the start. The flourishing of our industry is proof that people want to do what is right in travel — we just have to make it possible for them."
The money for this initiative comes from conservation licences that the companies issue to each guest. Providing the licence document during a trip allows guides to talk about the link between bear conservation and ecotourism with visitors, and is positively received by guests, says Smith.
CVBA members are local businesses with a small footprint. They limit the number of guests to protect the carrying capacity for the places and the wildlife. Their bear guides are all properly trained and certified in bear viewing best practices by the CVBA.
Read the full news release on the CVBA website.
Read about Maple Leaf Adventures bear viewing trips in the Great Bear Rainforest and Alaska.


The attorneys of the Nyce Law Office have extensive experience representing the interests of Boyertown area municipalities. Call us today for a consultation.
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Our municipal attorneys also have represented municipalities in litigation matters such as eminent domain, code enforcement, and assessment appeals. We have successfully litigated Sunshine Act, Right to Know, Mandamus, and Injunction cases in the federal and state courts. We zealously defend our clients when actions are brought against them and we consistently keep our clients fully informed and involved as litigation matters progress.
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Because of our in-depth experience and strong connections with municipalities, we are often called upon to act as municipal special counsel. For the same reasons, we represent private clients who are involved in legal matters where the government entity is not our client.
Do you have a municipal law question? Call us today at 610-367-2921 or contact us to arrange an initial consultation with one of our attorneys.


"It's not the color of our skin that makes us different, it's the color of our thoughts" that's what Steven Aitchinson was developing in his bestseller on personal development and what neuroscience is deepening today scientifically by digging the trail of Howard Gardner the pioneer of "multiple intelligences". Thus diversity is expressed well beyond skin color, gender or social class and intelligence beyond classical IQ, but in the "multiplicity of intelligences" that we are discovering! and at the time of collective intelligence, multiple intelligences deserve to be known. Decryption.
In the 70's are questioned the 2 types of recognized intelligences: logico-mathematics and linguistics. They are also put in opposition as are the left brain and the right brain and institutionalized through sectors, the scientist and the literary. Howard Gardner, a developmental psychologist, published in 1983 his work on the 9 types of intelligence (**) and the importance of underestimated intelligences in evaluation systems such as intelligences, intra and inter-relational which correspond to "soft skills".
Today the books flourish on the subject, with an overbid of types and numbers of intelligences. I will only mention the most recent in the catchy title "You are 10 times smarter than you imagine" (***) that decrypts the success of personalities in the business world and show business.
A 10th intelligence appears, that of "the intelligence which-am I?" Which includes the knowledge of oneself through the knowledge of its multiple intelligences! IQ is only a tiny part of self-knowledge, kinesthetic intelligence allowing the emergence of sports champions for example.
Difficult not to focus on emotional intelligence propelled on the front of intelligences and popularized through the works of Daniel Goleman (****); awareness and knowing how to manage one's emotions will be one of the keys to leadership and well-being and measuring one's EQ (Emotional Quotient) becomes a must.


Friendship Force of Sacramento - Day 2 Brunch!
Our club members and home hosts were distributed amongst five (5) of the Blue Mountains Club members homes for a fabulous brunch. While each home may have served slightly different foods, each of us raved about the wonderful spread provided by the brunch hosts. Mimosa's seemed to be the common thread to start off what turned out to be about a 4 hour eating frenzy, wonderful conversation and getting to know other members of the Blue Mountain Club. Of course Friendship Force traditions were discussed and our club members were very impressed with this brunch activity; it will take the place of home hosted dinners this week and several of us think we would like to initiate a brunch activity in our upcoming exchanges.
We then each left the brunch homes and branched out on our own with our hosts. Reports back from the Ambassadors found them in multiple locations during the day.
b. Several made visits to areas where we could look out onto the magnificent valleys and see the truly Blue Mountains.
c. Bird Watching and picture taking of course is a must.
d. Hiking was in order for one or two.
e. Stopping for tea of course!
f. Hydro Majestic, Medlow Bath upgrade and remodel, and were able to also observe a local wedding with a view of the Blue Mountains!
A wonderful day and more to come!


text:
ThinkNexT
info@thinknext.be
Minderbroedersstraat 17 box 2, 3000 Leuven
MULTIPLAYER GAME
Cities of Faith is an online multiplayer game built by the ThinkNexT founders. The game requires no upfront installation and is directly playable from the browser. The game won the Best Online Application award in ING's Start Academy competition.
CITIES OF FAITH
Cities of Faith is an online, turn-based multiplayer game combining elements of strategy, adventure and politics. The ThinkNexT founders designed the graphics, created the user interfaces and developed the server-side. It is a stand-alone application integrated into the browser, launchable with a single click.
FREEMIUM MODEL
Cities of Faith employs a freemium business model. The game is free, but a charge applies to some aspects of the game. That is realized through a credit system were players are able to buy credits they can use in-game. For that reason, the application interfaces with payment systems Paypal and Ogone.
Both application and server-side are built with Java EE technology. AspectJ is used for database connectivity and security. Graphics rendering is done through a custom developed tile-rendering engine. Because the game targets the online community, the website integrates with Facebook.


text:
module.exports = {
  'preprocessor:injectHtml': ['factory', require('./injectHtml')]
};

redpajama_set_name: RedPajamaGithub


text:
NEL ASA: Announces reestablishment of large-scale hydrogen production in Glomfjord
Thu, Apr 21, 2016 08:00 CET
(Oslo, 21 April 2016) NEL ASA (NEL), through a subsidiary, announced today that it has entered into a Letter of Intent with Meløy Energi AS and Meløy Næringsutvikling AS to establish Glomfjord Hydrogen AS (Glomfjord Hydrogen), for the potential development of a large-scale, low-cost hydrogen production facility in Glomfjord Industrial Park in Meløy, Norway.
"We are very excited to start working with our partners in Meløy in an area that historically has played such an important role in Norwegian hydrogen production. The project allows us to tap into extremely good energy access in the form of clean hydropower and take advantage of existing infrastructure in the Glomfjord Industrial Park." says Jon André Løkke, CEO of NEL ASA.
Glomfjord Hydrogen will be marketed as a hydrogen fuel provider for industrial applications, as well as personal- and public transportation, particularly focusing on supplying low-cost hydrogen to fossil fuel-converted ferries.
"Electricity generated in Glomfjord is difficult to transport cost effectively, meaning the energy is best utilized locally. With the current price of electricity, we can produce low-cost hydrogen for converted diesel vessels, which will be significantly more cost efficient than operating today's conventional ferries," says Løkke.
The available buildings and infrastructure at the industrial park provides flexibility and a scalable production model for Glomfjord Hydrogen. The facility will be developed in parallel with the increased demand, and is expected to have a production potential of up to 6000 kilograms of low-cost hydrogen per day.
"Hydrogen plays an important role in the future of energy production. Meløy municipality is excited to welcome a partnership with NEL that is in step with the need to focus on cleaner energy and renewable sources of fuel. Until 1993, Glomfjord Industrial Park was the largest hydrogen production site in the world. We have the experience, expertise and infrastructure necessary to succeed. We are looking forward to work with our partner to develop Glomfjord Hydrogen AS," says Sigurd Stormo, Mayor of Meløy.
Jon André Løkke, CEO, +47 90 74 49 49
Bjørn Simonsen, market development and public relations director, + 47 97 17 98 21
Sigurd Stormo, Mayor of Meløy, + 47 90 99 05 35
NEL ASA is the first dedicated hydrogen company on the Oslo Stock Exchange. Since its foundation in 1927, NEL Hydrogen has a proud history of development and continual improvement of hydrogen plants. NEL is global a supplier of hydrogen solutions, covering the entire value chain from hydrogen production technologies to hydrogen refuelling stations for fuel cell electric vehicles. H2 Logic A/S is a leading manufacturer of H2Station® hydrogen refuelling stations that provides fuel cell electric vehicles with the same fast fuelling and long range as conventional vehicles today. www.nel-asa.com
OSE-filing NEL Glomfjord