I love doing things that the entire family can enjoy together and visiting the zoo is definitely one of those things. Both Alleigh and Kaelyn love animals – in fact for Halloween this year they are being their favorite animal (pictures soon) – so if I mention visiting the zoo they are all about it. And even though Dustin isn't the kind of guy to show his emotions on his sleeve I can tell he enjoys visiting the zoo by how he lingers at certain animals and points things out to the girls. Now Willow… she's happy wherever we go … …..
Last week the girls and I went on a little over night trip to Put-In-Bay with my parents and I thought they would have a blast checking out the African Safari Wildlife Park in Port Clinton, Ohio on our way home. There is so much to do at the African Safari Wildlife Park including a drive-thru safari, walk-thru safari, pig races, educational shows and so much more. We arrived soon after the park had opened and so we decided to do the drive-thru safari first with the thought that the animals would be very active in the morning since it … …..
Almost a year ago Alleigh won a goldfish at the Stark County Fair and now both girls are ridiculously attached to "Swimmie" – very original, hehe. The fascination they have of their beloved Swimmie has also grown an interest in almost all creatures that make their home in the water, so when we had the opportunity to visit the Greater Cleveland Aquarium (Cleveland, Ohio) I knew they would love it…. and I was definitely right! When we first arrived at the aquarium our family was treated to a wonderful breakfast with the other blogging guests, had a visit from the … …..
Well I'm a still a bit in shock that my girls are now four and two years old. Time truly goes too fast and I have been trying to make every moment count. And so when I found out that Dustin would have a Friday off from work (he typically only has Sunday off) – the entire Friday – I knew we had to do something fun with the girls and so we headed to the Cleveland Zoo! As we were pulling out my sister pulled in the driveway and so she joined us. Dilly has a slight obsession with … …..


you can easly download it and start to use in your mobile phone.
of course if you are rich and has alot of money better buy but if you want to just try it for a while you can download this cracked verision.
but be careful before use it and dont forget to check it with your antivirus.


But, what if the company had given Cokes away to people who hugged each other (!) or to people who pretended to smile (like Unilever did in the video below this one)? Coke chose to reward people for hugging a (vending) machine – it feels less "happiness" and more Hal9000.
Last year Unilever developed an ice-cream vending machine with built-in facial recognition software that dispensed ice creams to happy (faces) people.


text:
Deadline for old Notes extended till Nov 24th
Exemption on old series of Rs 500, 1000 notes for certain categories extended till November 24 midnight, said Shaktikanta Das, Economic Affairs Secretary. The millions who are scrambling across the country to exchange their old notes and pay their utility bills, the Government on Monday announced that old Rs. 500 and Rs. 1,000 notes can to be used until November 24 for certain transactions.
The time limit to use old notes for paying household utility bills, fuel, taxes and fees as well as purchases from co-operative stores was set to expire on November 14 (tonight), but in a huge relief, the government has extended the deadline by ten more days.
The the government had allowed use of the old currency at government hospitals, railway ticketing, public transport, airline ticketing at airports, milk booths, crematoria/burial grounds and petrol pumps. This list was later expanded to include payments for metro rail tickets, highway and road toll, purchase of medicines on doctor prescription from the government and private pharmacies, LPG gas cylinders, railway catering, electricity and water bills and ASI monument entry tickets.
Also, the cash withdrawal limit at re calibrated ATMs was hiked to Rs 2,500 from Rs 2,000 a day. But we are not sure whether you will want the new 500 and 2000 rupee notes as there is a crunch for change.The weekly limit of Rs 20,000 for withdrawal from bank counters was increased to Rs 24,000 and the maximum limit of Rs 10,000 per day on such withdrawals was also scrapped.
Exchange limit reduced to Rs 2,000 from Nov 18th
Rs 2000 Notes printing stopped for Rs 200 Notes
RBI to issue Rs 200 notes in coming month
Former CM Jayalalitha Hospital Bill Crosses Rs 80 Crores

redpajama_set_name: RedPajamaCommonCrawl


Rebel: There is a question, if a person made merit but feel sad about it. Will that person gain benefit of making merit?
Dark Forest : Yes, the person will gain benefit following the law of Karma. Like when we plant a tree. We may plant ignorantly, we may plant wholeheartedly, or we may plant sufferingly feeling annoyed everytime we see the plant. The plant will be there, regardless to the state of our mind. Making merit is an action, and the fruit of Karma will follow of that action. But there is also an opportunity of the mind. We could be truly happy with the merit we made. The fruit of the merit could be harvested again and again. It is like a miracle how the single merit we made wholeheartedly, could bring us happiness time after time.


Concern over water supply in New Hampshire, driven by demand from rapid development and an increasing awareness to the delicate nature of natural resources, has again sparked the attention of many in the state, including the Department of Environmental Services.
In the latest efforts, new rules for registration and reporting of water use are nearing completion. These new regulations are likely to attract extra attention from private users, environmental advocates and regulators. With an unusually dry spring and minimal snowmelt, the annual attention paid to water shortages will only be exacerbated.
For many ordinary water users, such as those who draw on the public water supply or private wells for household or small business uses, water user registration and reporting rules are likely unfamiliar. By contrast, however, the heaviest of water users — such as those involved with agricultural, energy production, construction, snowmaking, aggregate, bottlers of various types and some golf courses — know vaguely of registration requirements and the need to report water withdrawals and discharges.
The new administrative rules are nearing the end of the rulemaking review process. Under the direction of the groundwater commission — a group convened to study ways to improve New Hampshire's ability to monitor and manage groundwater — the new rules will tighten registration and reporting requirements.
RSA chapter 488, titled "Water Management," became effective Jan. 1, 2006, and affirms the statutory authority for registration and reporting rules. RSA 488:3 expressly requires DES to administer a revamped water user registration and reporting program. The new statute also establishes accuracy requirements for usage reporting and enables DES to inspect facilities and fine violators.
Although not yet effective, the current draft of the proposed registration and reporting rules illustrate key differences from the outgoing rules. While many of the key components of registration and reporting remain unchanged, the new rules clarify several areas that had resulted in inadequate reporting under the old rules.
Any water user having to register should take time to understand the requirements proposed by the draft rules.
• The threshold to qualify for registration and reporting by a single real property or place of business continues to be cumulative water use that exceeds an average of 20,000 gallons of water per day in any seven-day period, or exceeds a total volume of 600,000 gallons in any 30-day period.
• Registration is still accomplished by submitting a form published by DES and providing identification information for the water user and the location.
• Measurement must still be accurate to within 10 percent of actual amounts.
• Registered users shall still report monthly water usage quarterly on forms published by DES.
• Water use measurement and calculation records must be retained by registered users for three years.
Perhaps the most significant change under the proposed rules is that each individual withdrawal, and each individual discharge point exceeding 20,000 gallons per day, is expressly required to be separately measured, unless a waiver is obtained.
• Under the old rules, registered users were not required to measure sources individually, even though the reporting requirements called for monthly water use per source or destination, thereby creating a point of confusion.
• New exceptions to the reporting requirements are proposed for test wells, pressure testing pipes or tanks and emergency cleanup in the case of spills.
• Registration forms shall require a statement of purpose for the water usage and shall locate individual withdrawal and discharge points on a topographic map.
• For purposes of measurement of open channel flow or pipe flow, the proposed rules adopt a more flexible "equivalent methods" approach enabling water users to choose a reliable method of measurement, subject to DES approval.
• Records of measurement device calibration and maintenance must be retained by users for five years.
• Rather than directly measuring output, agricultural water users may estimate water use based on pump capacities and duration of pumping.
• Upon registering with DES, a water user constructively grants permission for the state to enter upon the property and inspect compliance.
• Whereas penalties were rare under the old rules, because there was no express enforcement mechanism, ignoring the new rules may result in administrative fines for the failure to register, false reporting, or tampering with any measuring device, under RSA 488:8.
In spite of the enhanced burden and enhanced enforcement remedies under these proposed rules, they still serve the interests of the heaviest water users. The data gathered is intended to help avoid potential future problems relating to well interference, declining water tables and diminished stream flows — consequences that would have the greatest negative impact on registered water users.
DES' efforts to further refine the water use data gathered under these registration and reporting rules demonstrate a convergence of public and private interests. Where the regulatory perspective is grounded in scientific data, industry practices that require significant water use are better positioned to defend historic water use practices against more extreme attempts to restrict or liberate heavy water usage.
*Erik Newman is admitted in New Hampshire.


You can grow flowers or you can grow weeds!
It was time to weed my garden on all levels – took a 5 day break from social media – day 1 was interesting then honestly didn't really miss it – now I did miss connecting with some people yet I found myself wasting time in some of the sites recently.
I also did an Invironment one where I stopped eating – only had water, green drinks and fresh coconut water, massages, gentle yoga, meditation, time in nature and a deeper diving during the lunar eclipse of old patterns and programs that no longer were serving me and were coming up to the surface to be cleared – once you put your awareness on things no longer working to see what that is then you can clear them.
Had some amazing synchronicities that were letting me know I was on the right path as when you are working with and from the heart you can't make this stuff up that happens to let you know keep going!!
I highly encourage spending some time going within, cleaning up any weeds of your internal garden – physically, mentally, emotionally and spiritually cause it is so worth it. When we let go of old programming, negative self talk, judgments, criticism, toxins from every day living, stress etc it's like pulling weeds from the garden so that the flowers – the truth, the beauty, the authenticity can shine through and we can connect to our self, our soul and our source better.
After all – in the world of Quantum Physics – where Everything IS Energy and the outer world is nothing but a reflection of the inner world therefore inside is where it starts!!
Got a few great things coming up so check back in!!
A flowering does not think of competing with the flower next to it – it just blooms!
No Competition, No Judgments – Just Be You!!


5 ES FAGIANI GABRIELE POL. SORISOLESE SCUOLA MTB S. & P.
6 ES BATTAGLIA ALEX POL. SORISOLESE SCUOLA MTB S. & P.
9 ES CATTANEO MATTEO POL. SORISOLESE SCUOLA MTB S. & P.
3 WI BIANCHI MARIANGELA A.S.D. CAPITELLI PED. CAST.
11 M2 BUTTE' ALESSANDRO A.S.D. CAPITELLI PED. CAST.
14 M3 ZENI RENATO TEAM SPREAFICO A.S.D.
11 M4 BONOMI MAURIZIO BIKERS PETOSINO SCUOLA MTB S. P.
8 M6 RONCALLI GIUSEPPE BIKERS PETOSINO SCUOLA MTB S. P.


text:
Q: Firebase authen robo stuck with gmail sign in When i create an Android app for my phone i manage to login with gmail but when the robot try it goes to checking info not in selecting account....
I tried it with release and with debug and still the same.
I also tried it on multiple phones from firebase but i get the same result every times.
Here what the robot see
Note that the first time i tried it works but after that the robot cannot connect to my app.

A: I solved the pb and i will give you the explanation in case of someone came into the same pb
It was because of the SHA-1 key and the sign of the application
It is a bad practice to do that with the real values :
So i used fake one in order to test proguard and stuff. But when looking for the SHA1 key i used sign report on Android Studio => it generate me the fake Sha1
This is why the bot could not connect to my application

redpajama_set_name: RedPajamaStackExchange


The IPKat brings news of a recent European Patent Office Enlarged Board of Appeals decision which determined the extent to which Divisional Patent applications can be narrowed, even after the parent application has lapsed.
The result makes inherent sense – Divisionals can be narrowed, even if the parent has lapsed and the normal rules of amendment apply as they would to non-Divisionals. Put another way – patentees can feel confident to file European Divisionals with broader disclosure than the parent, now knowing that later narrowing amendments will be allowed.
European Divisionals can been used to great strategic effect (to have a second bite of the prosecution cherry, to buy time, etc.) and are part of normal practice before many patent offices. There seems to me to be scant justification to treat them any differently to the parent.
I'm not sure it's correct to say that patentees can feel confident to file divisionals with broader disclosure (I presume you mean additional subject-matter). The Examining Division is good, but not infallible, and the Article 123(2)/(3) trap still exists.
in such a way as to extend the protection conferred.
That's quite true. Applicants who have filed divisional applications which the EPO considers include additional subject-matter can breathe a sigh of relief. They will be permitted to amend to remove the additional subject-matter without losing divisional status (as was the practice before the referral to the Enlarged Board).However, a distinction should be drawn between the practices of some regimes, on the one hand, which allow the inclusion of further subject matter, perhaps considering it to have a later priority date, and of the EPO, on the other hand, where the presence of additional subject-matter in a patent is a ground for (potentially incurable) invalidity.


Asthma can be a very serious lung disease that restricts a person's airways, causing them to breathe improperly.
Asthma can be triggered by a number of things and each individual can be affected differently. Most individuals who suffer with asthma use inhalers to help when an attack is approaching or when they are having an attack. Depending on the severity of their attacks, some Doctors may require the patient to take prescription medications. This is a lifelong battle for most, and fortunately, some people have found relief through Chiropractic.
Chiropractic treatments have been able to help some people with their asthma conditions. They have found relief, improvement with breathing, and even infrequency in attacks; all through the help of Chiropractic. It is important to know that not all asthma related patients will have the same results with chiropractic care, but that it is worth it to try. Spinal adjustments directly affect the nervous system, the same with asthma. With Chiropractic focusing on subluxations and relieving the nervous system of stressors, asthma and other related respiratory issues have been able to find options outside of medications.


Report ATOM-371 Openload link 1?
SCOP-029 When I Went to My Friend's House to Hang Out, I Unexpectedly Saw His Little Schoolgirl Sister Naked with Only A Bath Towel. She Tempted Me With Her Suggestive Gaze, And There Was Only One Thing A Red-Blooded Male In His Prime Could Do!


text:
DEBBIE DRAKE ON JUDGING PANEL AT FX AWARDS
On Wednesday night, Associate Director Debbie Drake attended the prestigious FX International Interior Design Awards as part of the VIP panel of judges.
The judging panel features independent experts who are recruited from across the industry and comprise engineers, clients, architects and designers from many different sectors to reflect the audience. As always, FX invited a completely fresh new panel this year of over 20 judges, selected for their experience, opinions and commitment to design.
Debbie has worked on some of KSS' biggest and most successful projects including the award-winning fan experience areas at Anfield for Liverpool FC, The Amex Community Stadium for Brighton & Hove Albion FC, and our new Leicester City FC Training Centre as well as the AXA Training Centre Liverpool FC shortlisted last year in the FX Awards Graphics and Wayfinding category.
Debbie said after the awards ceremony, "I was honoured to be part of the selected judging panel at this year's FX Design Awards. It was a difficult task to decide due to the high calibre of entries, but it was wonderful to enjoy such a spectacular evening with all of the worthy winners and my fellow judges from across the industry, and in the words of our hilarious host Miles Jupp 'It's the one that really matters'".
KSS look forward to the FX International Interior Design Awards 2023.
Debbie Drake Associate Director


text:
The original market building in which we call home, had a large lead roof hence the name Leadenhall, and although it's not certain it was built as a public place, by the end of the 14th century it was firmly established as a market and for many years was the site of the City granary. Unfortunately the original Leadenhall was badly damaged in the Great Fire of 1666 and was rebuilt in its present form by Sir Horace Jones. It continued to function as a market with the majority of the traders being fishmongers and butchers; even today there remains a butcher in Central Avenue.
The site itself has grander origins than the 14th century market. Built in 50AD and then rebuilt in 120AD, by the romans, it formed part of the Basilica, which was then the largest building of its kind except for the Basilica Ulpia in Rome itself.
The Lamb Tavern became a pub in 1780 and started as a private house selling real ale. After it was purchased by Young's, it became famous for selling its own beer to the public and continues to do so up to the present day. We've continued our partnership with Young's as an ever-popular hotspot for proper pub grub, carvery and real ale in the hub of the city.


REALTORS® are the "real" experts on all facets of buying and selling a home. A clear indication of just how REALTORS® are translating their skills into tangible results occurred in the third quarter. The Canadian Real Estate Association reported a record-breaking third quarter with 135,182 MLS® units sold, which was up 18 per cent from the third quarter last year. September 2009 was also the best September on record with 42,497 MLS® sales.
WinnipegREALTORS® enjoyed one of its best third quarters on record, and had its best September ever in both sales and dollar volume. The success of this year's third quarter ensures a third consecutive year of over $2 billion in MLS® sales activity.
It is interesting to note the recovery of the national MLS® market this year. At the peak of the recession, there was an inventory build-up of 12.8 months in January 2009, which dropped to 4.9 months in September this year. Winnipeg's listings supply had decreased as well, but not to the same extent, as the local market has always been more stable than other regions of the nation.
However, Winnipeg's current inventory remains tight with a little over two months of home listings available. Of course, like any other market region, listing supply varies according to the MLS® area, price range and property type — you need to be talking to your REALTOR® about your own particular situation.
Looking ahead, the Bank of Canada maintained its overnight lending rate target this week at 0.25 per cent and the bank rate at 0.5 per cent. Since inflation is subdued as a result of continuing economic challenges in Canada, the central bank does not see a need to change the historically low rate until at least the first two quarters of 2010.
Despite concerns with a higher Canadian dollar hurting Canada's exports, the Bank of Canada is projecting the Canadian economy will grow by three per cent in 2010 and 3.3 per cent in 2011, after contracting by 2.4 per cent this year.
A REALTOR® recently said he used another REALTOR® to sell his home. Why? He was too emotionally attached to his family home and could not be objective enough to make the right decision.
By the way, Manitoba law requires whether buying or selling a home, a REALTOR® must disclose on the offer to purchase that they are a REALTOR®.
Whether selling your home or looking to buy one, the over 1,400 REALTORS® in Winnipeg and surrounding rural municipalities work together to help you! This REALTOR® network (96,000 across the country) shares information and resources that places you in the best position possible to secure the biggest financial investment of your lifetime.
Not all licenced or registered brokers and salespeople are REALTORS®. Only real estate licensees who are members of the Canadian Real Estate Association (CREA) are REALTORS®. These REALTORS® are committed to a high standard of professional conduct, ongoing education, and to a strict code of ethics and standards of business practice. Using the service of a professional REALTOR® helps in disclosing maximum property information and facts therefore reducing your risk.
• Your REALTOR® can help determine your buying power and refer you to lenders best qualified to maximize your loan and minimize your cost.
• Your REALTOR® has full access to all the features of the Multiple Listing Service®, Canada's most powerful real estate marketing network.
• Your REALTOR® provides local community information on utilities, zoning, schools, etc. REALTORS® assist you in making the best choice when selecting an environment where you and your family can grow.
• Your REALTOR® has a finger on the pulse of the housing market and is knowledgeable about developments and trends in real estate.
resale value when you are ready to sell.
• Your REALTOR® can negotiate the best deal. There are myriad negotiating factors, including price, financing, terms, date of possession and often the inclusion or exclusion of repairs, furnishings or equipment. By negotiation alone, your REALTOR® often saves you more than the cost of their service.
• Your REALTOR® assists you in providing due diligence to evaluate the property. This may include inspections for mold, dry rot, asbestos, faulty structure, roof condition, septic tank and well tests, just to name a few. Your REALTOR® can assist you in determining what conditions to recommend and assist in finding qualified professionals to investigate and provide reports to you.
• Your REALTOR® can guide you through the sales process making sure everything flows smoothly from initial offer to closing.
• Your REALTOR® markets your property to other real estate agents and the public. Often REALTORS® will provide guidance on staging or repairs that enhance the salability of your property. Your REALTOR® will harness the power of the MLS® to expose your property to a large network of qualified buyers as well as co-ordinate marketing through the most effective array of other advertising media. Only Winnipeg REALTORS® have access to the marketing exposure of the Winnipeg Real Estate News.
• All REALTORS® are graduates of a real estate education program and are committed to pursuing ongoing professional development courses.
• REALTORS® must adhere to a strict Code of Ethics and Standards of Business Practice; your guarantee of professional conduct and service excellence.
• All REALTORS® carry errors and omissions insurance.
• The Real Estate Insurance Alliance Fund is available to you in the rare event of fraud or breach of trust by a REALTOR®. It is your protection against financial loss. This fund is financially supported by our members.
• A licenced brokerage supervises the business conduct of all REALTORS® to ensure their compliance with Manitoba law.
Why the registered "®" after the word REALTOR®?
Only REALTORS®, who are members of the Canadian Real Estate Association and a local real estate board, or association, can call themselves REALTORS®.


TFE Hotel's Vibe Hotel Sydney has undergone a major transformation, to reveal refurbished rooms, conferencing spaces and a new dining concept.
The Goulburn Street property's 198 guest rooms, including 13 suites, have a new modern look, inspired by a rich blue and natural timber colour palette.
The hotel also offers a master suite with two bedrooms, plus a selection of family rooms that sleep up to four people.
The 4-star hotel's two conferencing spaces, rooftop swimming pool and ground-floor lobby have all been updated to bring the property in line with the eclectic Vibe brand, which relaunched in 2015.
Vibe Hotel Sydney's new bar and restaurant, Storehouse Sydney Central, joins the ranks of nearby restaurants and laneway bars on the hotel's doorstep.
The opening follows the successful launch of Storehouse Rushcutters Bay at the Eastern Suburb's Vibe Hotel.
TFE Hotels chairman Allan Vidor welcomed the new-look hotel into the portfolio.
"Vibe Hotel Sydney is positioned in one of the liveliest locations in the city, offering access to an unparalleled suite of facilities in one spot," he said.
The renovation works were a collaboration between TFE's in-house design team and interior design studio, Des-signer.


Learn to secure your whole site against cybercriminals with this WordPress Security: Secure Your Site Against Hackers training course! The course starts with the two biggest causes of hacks on websites and shows you the simple and non-technical ways to protect yourself.
In this WordPress Security: Secure Your Site Against Hackers course, you will learn how to use secure and unguessable passwords that are different on every site. Then you will understand how to ensure that ALL the software that's used to run your site – not just WordPress – is not only up-to-date, but KEPT up-to-date. You will also learn about home directory and webroot hygiene as well as disabling directory listing and error reporting.
Lastly, you will learn how to set up and schedule back-ups, so if anything goes wrong in the future you can restore your site back to an early copy. Plus you will get a step-by-step explanation of technical methods used to really lock down a WordPress website.
Online security is of paramount importance to every human being on this planet. Therefore, this WordPress Security: Secure Your Site Against Hackers course is for everybody. There is very little use of technical terminology or advanced online procedures. Anyone with basic computer skills can protect any WordPress website by following this course.
Cyber-criminals are out there using sophisticated software to scan the internet for any type of vulnerable website. Hackers don't care if your website is big, small, a non-profit, or profit making. A hacked website is worth money to them as they can either extort money from a website owner, or place links or code on the site to support some other type of criminal activity.


Whilst care is taken in its preparation, we accept no liability for any loss or damage incurred as a result of acting on or refraining to act on information or other material within this site. You should always seek professional advice on the facts of your particular case.
Sykes Anderson Perry Ltd is incorporated in England and Wales. Company number 08889045. Registered office 9 Devonshire Square, London EC2M 4YF. A list of members is available for inspection at that address. It is regulated by the Solicitors' Regulation Authority under no 612251, whose rules can be accessed via the http://www.sra.org.uk/code-of-conduct page.
All references to "Sykes Anderson Perry", "the firm" and the like should be read as referring to Sykes Anderson Perry Ltd. We use the word "director" to refer to a member of Sykes Anderson Perry Ltd or a consultant with equivalent standing and qualifications.
The firm is not authorised under the Financial Services and Markets Act 2000 but we are able in certain circumstances to offer a limited range of investment services to clients because we are members of the Law Society. We can provide these investment services if they are an incidental part of the professional services we have been engaged to provide. We do not give investment advice and nothing in this website or in any communication or article or similar by us is to be taken as inviting you or encouraging you to invest in any particular asset or investment. You should take appropriate independent advice from suitably qualified and regulated persons.
If you would like to comment on how the service to you could be improved, or should there be any aspect of our service with which you are not satisfied at any time, you should raise the matter with the lawyer handling your work and/or the director responsible for that lawyer's work. If you would like to make a formal complaint, including a complaint about any bill we have delivered to you, you should do so in writing addressed to the Complaints Director, Christopher Sykes, and ask for a copy of our complaints procedure. We will look into your complaint carefully and promptly. If for any reason we are unable to resolve any problem between us, you may be able to use the complaints and redress procedures operated by the Legal Ombudsman. This service is open to all members of the public, certain small businesses, charities, clubs, societies, associations and trusts. There are time limits on making such a complaint, generally within six months of our written response to your complaint and within one year from the act/omission complained of or one year from when you should reasonably have known there was cause for complaint. The contact details for the Legal Ombudsman are www.legalombudsman.org.uk, tel 0121-245-3050 or enquiries@legalombudsman.org.uk. The Solicitors Regulation Authority is our professional regulator and handles any complaints relating to professional misconduct.
Pursuant to our obligations under the anti-money laundering laws and our professional obligations in the countries in which we operate, if you instruct Sykes Anderson Perry , we will use various available sources of information to establish certain matters about you, such as verifying your identity, including electronic verification.
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To the extent permitted by law, we do not accept responsibility for any loss which may arise from reliance on information contained in these pages. Furthermore, Sykes Anderson Perry does not endorse or accept responsibility for the material of any website referred to or accessed through this site.
You may link to this site provided you link to our top level page and you do so in a way which indicates the link is to the Sykes Anderson Perry home page, is fair and not misleading. You may not display the contents of any of this site in a frame surrounded by other material not originated by us.
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These scams will often originate by email, and usually involve offering a large sum of money to the victim (such as an inheritance, unclaimed bank funds, lottery wins, or even loans), in return for paying a more modest sum, often referred to as transaction fees or brokering costs. Key to the scam is the entering into any form of communication with the victim.
If you receive an email of this nature claiming to be from Sykes Anderson Perry, do not correspond with the sender. It is highly unlikely that it originates from Sykes Anderson Perry. Please forward it to solicitors@saplaw.co.uk and we will advise accordingly on whether it comes from Sykes Anderson Perry.
Neither Sykes Anderson Perry Ltd nor any of its partners, employees, or consultants will be responsible for any losses incurred by any such scam.
Sykes Anderson Perry Ltd is incorporated in England. Company number 08889045. Registered office 9 Devonshire Square, London EC2M 4YF . A list of members is available for inspection at that address.


text:
Q: Error: Package: python-devel-2.6.6-64.el6.x86_64 Requires: python-libs(x86-64) = 2.6.6-64.el6 found: python-libs-2.6.6-66.el6_8.x86_64 I am getting this error on running python setup.py for installing cffi python module.
c/cffi1_module.c: At top level:
c/cffi1_module.c:128: error: expected '=', ',', ';', 'asm' or '__attribute__' before '*' token
c/cffi1_module.c:150: error: expected '=', ',', ';', 'asm' or '__attribute__' before '*' token
c/_cffi_backend.c:6691: error: expected '=', ',', ';', 'asm' or '__attribute__' before 'init_cffi_backend'
error: command 'gcc' failed with exit status 1
error: command 'gcc' failed with exit status 1,

So this error on googling shows that I need to install python devel and on doing that I get the error below:

Error: Package: python-devel-2.6.6-64.el6.x86_64 (rhel-6-server-rpms)
           Requires: python-libs(x86-64) = 2.6.6-64.el6
           Installed: python-libs-2.6.6-66.el6_8.x86_64 (@rhel6-patch-channel-may2015)
               python-libs(x86-64) = 2.6.6-66.el6_8

According to the error- Requires: python-libs(x86-64) = 2.6.6-64.el6 but installed is- python-libs(x86-64) = 2.6.6-66.el6_8, so how can I change it?

A: Your rhel-6-server-rpms channel is not the official version.  The current rhel-6-server-rpms channel contents actually has Python at version 2.6.6-66.el6_8.x86_64, so the problem would not happen with it.  You need to look at yum repolist -v output and double-check that you are using the official repositories.  (You will need an active Red Hat Enterprise Linux subscription to access these repositories.)


Sydney Coach Campbell Aitken said these two games are important. "It's huge, it gives the players the ambition to take that next step. It's a good step up from what they have been playing and a good transition into the Super W format," he said.
This year's Jack Scott Cup has shown that there's a plethora of talent coming through the ranks in women's rugby with all of the competition's clubs being represented in either side. The Sydney squad features 14 players from competition leaders, Sydney University.
Sydney have included Josephine Falesita, Chloe Leaupepe, Fiona Jones, Ash Hewson, Iliseva Batibasaga, Tasmin Sheppard, Natalie Maclaren, Ana-lise Sio and Alex Sulusi. These players will add plenty of firepower as they are back playing together for the first time since their title winning campaign for NSW in the Super W.
Aitken highlights the younger members of the squad and what they can bring to the team.
"There's a couple of really young players in there, Phoebe Loughhead who's currently in year 12 doing her HSC, she's got a bright future ahead of her and Shenai Lendill from Warringah looks really sharp," he said.
The NSW Country squad includes some of the best players from the country competitions, such as Newcastle University's Britney Duff, the 2017 NSW Country Women's Rugby Union Player of the Year.
NSW Super W squad members, Katrina Barker, Alafou Fatu, Nancy Vaiaku, Inge Visser and Matalena Wilson will also be donning the orange jersey for the two games, adding plenty of experience and a winning culture to the side.
The games between Sydney Women and NSW Country Women will be played alongside two NRC fixtures. The first hit out is scheduled to be on Sunday 23 September at Concord Oval as part of a double header with Sydney vs Fiji NRC.
The second round of action will be another double header when the NSW Country Eagles take on Brisbane City on Sunday 7 October at Camden.


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Seven Devon churches
A poem by E E Cummings starts: 'I am a little church no great cathedral' and we make no secret of the fact that it is East Devon's little churches that tug at our heart-strings, while the grandeur of the likes of its great cathedral is appreciated on a more intellectual level.
The Cathedral Church of St Peter in Exeter
Exeter Cathedral's dizzyingly high ceiling © Heart of Devon
It's hunkered solidly there on the green, the weight of centuries pressing it into Exeter's earth, yet when you step inside the door your eye swings immediately up to the space and grace of its amazing roof: the longest unbroken stretch of Gothic vaulting in the world.
When you've recovered from the impact of its size and grandeur, you can focus on small, intimate details: the individual faces of the figures on the towering frontage, animals on the choir stalls, sweet-faced angels playing musical instruments, sad swans with entwined necks, intricate roof bosses, a little 13th-Century carved wooden elephant – so many, so absorbing, and such a personal glimpse into centuries of human history.
St Giles & St Peter, Sidbury
Harvest time in Sidbury © Heart of Devon
Sidbury's great treasure is what's believed to be a Saxon crypt in the apparently 12th-century church of St Giles & St Peter. One of only six known in England, it was discovered in 1898, and a guided tour of it and the church is given on summer Thursdays; otherwise it is closed to the public. The church tour starts at 14.30 and reaches the crypt at around 15.30. I found the tiny, plain underground chamber unexpectedly moving; who knows what Saxon voices may have echoed there some 1,400 years ago? The church itself has Norman features (the tower is 12th century) but in fact is a mixture of styles, having been much altered over the years. It has some fragments of medieval wall painting, a painted gallery, some good Victorian stained glass and seven green-man carvings in the roof. Rather surprisingly, gunpowder was stored above the porch during the Napoleonic wars.
St Olave's Church, Exeter
Situated on Fore Street, this is a Saxon church with a separate Saxon tower. It was originally a chapel and was possibly built for King Harold's mother, Gytha. St Olav was an 11th-century Viking king who converted to Christianity. In fact Harold had given him the choice of either converting or being beheaded, so he took the more comfortable option – but then died in battle anyway. After his death it is said that his nails and hair continued to grow and a stream of clear water gushed out from his grave, hence the sainthood.
St Martin's Church, Exeter
St Martin's Church tucked in the corner of Cathedral Square © Heart of Devon
This beautiful little church is squashed into a corner of Cathedral Close. The original church, consecrated by Bishop Leofric in1065 and one of the oldest in Exeter, was rebuilt in the 15th century, in red Heavitree stone; some masonry and features from the old church are thought to have been reused. With so little space available, the east end was built at a skewed angle and the tower was added later, on a piece of rented land. The dramatic front window (of Beer stone) and other windows date from the 14th century. Its parish area is tiny, a mere 1.75 acres (0.7 hectares), yet in 1821 it held 329 residents, in houses that have long since gone. Towered over by the so-called 'Mol's Coffee House' next door, St Martin's is now well cared for by the Churches Conservation Trust.
The Church of St Mary, Ottery St Mary
The Church of St Mary, Ottery St Mary © Tony Howell, Heart of Devon
The church of St Mary is undoubtedly what draws visitors to the town. The manor of Ottery was given to the cathedral of Rouen by Edward the Confessor, and wrested back in 1334 by Bishop Grandisson who set about rebuilding the church, modelling it on Exeter Cathedral. It was added to in the 16th century and in the Victorian era. And repainted in 1977. No one can miss the two monuments to the Grandissons who lie on each side of the aisle under elaborately carved canopies. Sir Otho de Grandisson was the bishop's younger brother. He died in 1359 and lies there in full armour, with his luxuriant moustaches draped over his breastplate. He has the knight's usual lion at his feet, symbolising strength, although it has lost its head. His wife, Lady Beatrix, looks as uncomfortable in death as she probably was in life: her hair is incorporated into a square headdress which has the effect of a pair of blinkers; this, along with the high collar of her dress, must have ensured that she faced life looking straight ahead at all times. Two little dogs nuzzle each other at her feet, their liveliness contrasting with their poor inanimate mistress.
The Church of St Michael, Shute
Shute's attractive little 13th-century church of St Michael was first built as a chapel, and is thought possibly to be on the site of an earlier Saxon place of worship. It has been much refashioned over the years but retains some attractive decoration (much of it in Beer stone), roof bosses, effigies and panels. There's a touching memorial to Sophia Anna, wife of Sir William Templer Pole, who died in 1808 aged 20: Her disconsolate husband, who no less tenderly loved her person than adored her virtues, unfeignedly lamenting his irreparable loss here consecrated this monument to her memory. St Michael's is a busy, active church with a strong sense of community. We have visited it for two flower festivals, which include a great many cream teas and slices of cake as well as a blaze of flowers, and always people have come up wanting to tell us proudly about their church.
(Photo: A floral bicycle on display in Shute church © Hilary Bradt)
St Petrock's Church, Exeter
Devon has 17 churches dedicated to St Petrock or Petroc, who visited the area in the 6th century. This one on Exeter's High Street may possibly date back as far as the 7th century in some form or other, although no Celtic traces remain. Part of its north wall dates from the 12th or 13th century. Extensions were patched on to various bits of it over the centuries, until historian Nikolaus Pevsner described its interior as being 'among the most confusing of any church in the whole of England'. Today it has been divided in two: the more recent parts are used as an office for the St Petrock's charity which does much-needed work among Exeter's homeless. It's also a campanology centre, with permanent displays and information about local and national bell-ringing societies.
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1 August 2017, Bamako - Nearly 56 percent of the rural population in Mali lives in poverty with limited resources to invest in agricultural activities. Among those, about 3 million people are classified as being at risk of food insecurity with limited access to social assistance or social services in general.
According to the March 2017 Cadre Harmonisé factsheet, around 3.188 million people are forced to resort to negative coping strategies to move out of situations of recurrent crisis, weakening their livelihoods even further.
Although important, short term humanitarian responses during recurrent humanitarian crises, cannot ensure that poor and vulnerable households are able to cope and withstand the impacts of the crises, while supporting their sustainable way out of poverty and food insecurity.
Until recently, the Government has developed and implemented social cash transfers programmes. However, much needs to be done to develop a social protection system that can foster the resilience and support the livelihoods of the poorest and most vulnerable rural households.
Social protection has proved to have positive impacts in the fight against hunger and poverty, including in the rural areas. However, given the multidimensional nature of these issues, social protection interventions alone cannot sustainably eradicate poverty and vulnerability, but they should be part of a broader strategy for sustainable development. In fact, linking social protection to the rural development sectors, namely agriculture, livestock, fisheries and forestry, can effectively contribute to the protection and promotion of the livelihoods of rural people, including the most poor and vulnerable.
Nonetheless, rural development actors are not usually equipped to take part in the design and implementation of agricultural policies and programmes which take in consideration the social protection components. Thus, most of the time, they do not take part in the national debate on social protection in Mali.
In this context, FAO and its partners organized a training workshop on the role of social protection for food security and nutrition, that took place in Bamako the 4th, 5th and 6th July 2017. The training was directed to actors in the rural development, social protection and food security and nutrition sectors.
Representatives of the Ministry of Solidarity and Humanitarian Action, Ministry of Agriculture, Ministry of Fisheries and Livestock, Ministry of Finance, and the Food Security Commission took part in the training, together with international partners and civils society organizations, for a total of 30 participants.
The training had three main objectives, the first one being the contribution to strengthening the capacities of rural development actors concerning social protection for food security and nutrition and connect them more effectively to the processes related to the Social Protection National Policy.
The second objective was to enhance the knowledge and understanding of social protection actors regarding the main interventions in the rural development sector. Finally, the third objective was to create a space for analysis and dialogue and to encourage the collaboration among different sectors.
As stated during the opening ceremony by Mr. Amadou Diallo, social protection technical Counsellor representing the Ministry of Solidarity and Humanitarian Action, «the National Social Protection Policy is a priority for Mali and the Ministry grants particular attention to it».
According to the Ministry of Livestock and Fisheries, represented by Ms. Gassama Adane Maïga, «the training will contribute to better organize our services to implement the measures stated in the agricultural orientation law, related to the social protection of rural people».
In a team work atmosphere, through different pedagogical methodologies, participants had the possibility to exchange their knowledge and discuss on concrete proposals for reinforcing intersectoral coordination in the fight against hunger and poverty in Mali.
As underlined by Joaquin Sachez, Programme Officer in FAO Mali: « FAO is strongly convinced that the social protection of farmers, fisheries and forest dependent communities, and all other rural people will only be achieved through an integrated and comprehensive framework of interventions, developed within a broader rural development strategy that can enable the rural population to sustainably move out of poverty […]. We will continue to be available and ready to help reinforcing the synergies between social protection and rural development with the final goal of breaking the cycle of rural poverty».
The Organization is reinforcing its contribution in the social protection and resilience agenda in Mali as the country is advancing its policies for extending the coverage of social protection to rural areas. This contribution includes also an ongoing study to assess the feasibility and propose integrated packages of social protection services to support the productivity of rural populations.
At the end of the three days' training, Ministries' representatives committed to strengthen intersectoral synergies and to reinforce joint actions that can allow the Malian rural population to benefit from social protection interventions and complementary programmes with the final objective of moving out of poverty.
The Bamako's training was in line with a larger effort of FAO to strengthen social protection for the resilience of rural populations and for food security and nutrition at regional level. Similar activities are being implemented also in Senegal, Burkina Faso, Niger and Chad.


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Changing nurses' views of the therapeutic environment: randomised controlled trial
Emese Csipke, Til Wykes, Stephen Nash, Paul Williams, Leo Koeser, Paul McCrone, Diana Rose, Tom Craig
Journal: BJPsych Open / Volume 5 / Issue 1 / January 2019
Published online by Cambridge University Press: 29 January 2019, e17
Although patients value evidence-based therapeutic activities, little is known about nurses' perceptions.
To investigate whether implementing an activities training programme would positively alter staff perceptions of the ward or be detrimental through the increased workload (trial registration: ISRCTN 06545047).
We conducted a stepped wedge cluster randomised trial involving 16 wards with psychology-led nurse training as the intervention. The main outcome was a staff self-report measure of perceptions of the ward (VOTE) and secondary outcomes measuring potential deterioration were the Index of Work Satisfaction (IWS) and the Maslach Burnout Inventory (MBI). Data were analysed using mixed-effects regression models, with repeated assessments from staff over time.
There were 1075 valid outcome measurements from 539 nursing staff. VOTE scores did not change over time (standardised effect size 0.04, 95% CI –0.09 to 0.18, P = 0.54), neither did IWS or MBI scores (IWS, standardised effect size 0.02, 95% CI –0.11 to 0.16, P = 0.74; MBI standardised effect size –0.09, 95% CI –0.24 to 0.06, P = 0.24). There was a mean increase of 1.5 activities per ward (95% CI –0.4 to 3.4, P = 0.12) and on average 6.3 more patients attended groups (95% CI –4.1 to 16.6, P = 0.23) following training. Staff feedback on training was positive.
Our training programme did not change nurses' perceptions of the ward, job satisfaction or burnout. During the study period many service changes occurred, most having a negative impact through increased pressure on staffing, patient mix and management so it is perhaps unsurprising that we found no benefits or reduction in staff skill.
2 - Social Computing Systems and Ethical Considerations
By Khurshid Ahmad, Shane Finan, Stephen Kelly, Xiubo Zhang, Paul Hayes, Linda Hogan, Damian Jackson
Edited by Khurshid Ahmad, Trinity College Dublin
Book: Social Computing and the Law
Print publication: 11 October 2018, pp 14-24
The First Cases of Evolving Glyphosate Resistance in UK Poverty Brome (Bromus sterilis) Populations
Laura R. Davies, Richard Hull, Stephen Moss, Paul Neve
Journal: Weed Science / Volume 67 / Issue 1 / January 2019
Published online by Cambridge University Press: 02 October 2018, pp. 41-47
Poverty brome (Bromus sterilis L.) [sterile or barren brome, syn. Anisantha sterilis (L.) Nevski] is a problematic UK arable weed. There are currently no confirmed cases of glyphosate resistance in any weed species in the United Kingdom or in B. sterilis worldwide. However, there are reports of poor control by glyphosate in this species. Here, we report experiments to confirm the suspected on-farm resistance of B. sterilis populations to glyphosate. Glyphosate screening and dose–response experiments established that glyphosate sensitivity of three UK B. sterilis populations exhibiting poor field control is outside the normal range of sensitivity of 30 sensitive populations and adjacent unexposed populations. Control of sensitive populations ranged from 49% to 82% and for suspected resistant populations from 21% to 30%. Dose–response ED50 values of sensitive populations ranged between 241 and 313 g ai ha−1; corresponding values of suspected resistant populations ranged between 420 and 810 g ha−1, and resistance indices ranged from 1.55 to 4.5. Suspected resistant populations were incompletely controlled at the recommended field rate of glyphosate (540 g ha−1), while adjacent unexposed populations were completely controlled. We conclude that some UK populations of B. sterilis have reduced glyphosate sensitivity and are in the process of evolving resistance. This is the first reported case of reduced glyphosate sensitivity in any UK weed species and in B. sterilis worldwide. This, coupled with increasing glyphosate use, highlights the need for increased vigilance and monitoring for glyphosate resistance in the United Kingdom.
Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis (STEPWISE): randomised controlled trial
Richard I. G. Holt, Rebecca Gossage-Worrall, Daniel Hind, Michael J. Bradburn, Paul McCrone, Tiyi Morris, Charlotte Edwardson, Katharine Barnard, Marian E. Carey, Melanie J. Davies, Chris M. Dickens, Yvonne Doherty, Angela Etherington, Paul French, Fiona Gaughran, Kathryn E. Greenwood, Sridevi Kalidindi, Kamlesh Khunti, Richard Laugharne, John Pendlebury, Shanaya Rathod, David Saxon, David Shiers, Najma Siddiqi, Elizabeth A. Swaby, Glenn Waller, Stephen Wright
Journal: The British Journal of Psychiatry / Volume 214 / Issue 2 / February 2019
Published online by Cambridge University Press: 25 September 2018, pp. 63-73
Print publication: February 2019
Obesity is a major challenge for people with schizophrenia.
We assessed whether STEPWISE, a theory-based, group structured lifestyle education programme could support weight reduction in people with schizophrenia.
In this randomised controlled trial (study registration: ISRCTN19447796), we recruited adults with schizophrenia, schizoaffective disorder or first-episode psychosis from ten mental health organisations in England. Participants were randomly allocated to the STEPWISE intervention or treatment as usual. The 12-month intervention comprised four 2.5 h weekly group sessions, followed by 2-weekly maintenance contact and group sessions at 4, 7 and 10 months. The primary outcome was weight change after 12 months. Key secondary outcomes included diet, physical activity, biomedical measures and patient-related outcome measures. Cost-effectiveness was assessed and a mixed-methods process evaluation was included.
Between 10 March 2015 and 31 March 2016, we recruited 414 people (intervention 208, usual care 206) with 341 (84.4%) participants completing the trial. At 12 months, weight reduction did not differ between groups (mean difference 0.0 kg, 95% CI −1.6 to 1.7, P = 0.963); physical activity, dietary intake and biochemical measures were unchanged. STEPWISE was well-received by participants and facilitators. The healthcare perspective incremental cost-effectiveness ratio was £246 921 per quality-adjusted life-year gained.
Participants were successfully recruited and retained, indicating a strong interest in weight interventions; however, the STEPWISE intervention was neither clinically nor cost-effective. Further research is needed to determine how to manage overweight and obesity in people with schizophrenia.
R.I.G.H. received fees for lecturing, consultancy work and attendance at conferences from the following: Boehringer Ingelheim, Eli Lilly, Janssen, Lundbeck, Novo Nordisk, Novartis, Otsuka, Sanofi, Sunovion, Takeda, MSD. M.J.D. reports personal fees from Novo Nordisk, Sanofi-Aventis, Lilly, Merck Sharp & Dohme, Boehringer Ingelheim, AstraZeneca, Janssen, Servier, Mitsubishi Tanabe Pharma Corporation, Takeda Pharmaceuticals International Inc.; and, grants from Novo Nordisk, Sanofi-Aventis, Lilly, Boehringer Ingelheim, Janssen. K.K. has received fees for consultancy and speaker for Novartis, Novo Nordisk, Sanofi-Aventis, Lilly, Servier and Merck Sharp & Dohme. He has received grants in support of investigator and investigator-initiated trials from Novartis, Novo Nordisk, Sanofi-Aventis, Lilly, Pfizer, Boehringer Ingelheim and Merck Sharp & Dohme. K.K. has received funds for research, honoraria for speaking at meetings and has served on advisory boards for Lilly, Sanofi-Aventis, Merck Sharp & Dohme and Novo Nordisk. D.Sh. is expert advisor to the NICE Centre for guidelines; board member of the National Collaborating Centre for Mental Health (NCCMH); clinical advisor (paid consultancy basis) to National Clinical Audit of Psychosis (NCAP); views are personal and not those of NICE, NCCMH or NCAP. J.P. received personal fees for involvement in the study from a National Institute for Health Research (NIHR) grant. M.E.C. and Y.D. report grants from NIHR Health Technology Assessment, during the conduct of the study; and The Leicester Diabetes Centre, an organisation (employer) jointly hosted by an NHS Hospital Trust and the University of Leicester and who is holder (through the University of Leicester) of the copyright of the STEPWISE programme and of the DESMOND suite of programmes, training and intervention fidelity framework that were used in this study. S.R. has received honorarium from Lundbeck for lecturing. F.G. reports personal fees from Otsuka and Lundbeck, personal fees and non-financial support from Sunovion, outside the submitted work; and has a family member with professional links to Lilly and GSK, including shares. F.G. is in part funded by the National Institute for Health Research Collaboration for Leadership in Applied Health Research & Care Funding scheme, by the Maudsley Charity and by the Stanley Medical Research Institute and is supported by the by the Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London.
Clozapine is associated with secondary antibody deficiency
Mark Ponsford, Daniel Castle, Tayyeb Tahir, Rebecca Robinson, Wendy Wade, Rachael Steven, Kathryn Bramhall, Mo Moody, Emily Carne, Catherine Ford, Daniel Farewell, Paul Williams, Tariq El-Shanawany, Stephen Jolles
Schizophrenia affects 1% of the population. Clozapine is the only medication licensed for treatment-resistant schizophrenia and is intensively monitored to prevent harm from neutropenia. Clozapine is also associated with increased risk of pneumonia although the mechanism is poorly understood.
To investigate the potential association between clozapine and antibody deficiency.
Patients taking clozapine and patients who were clozapine-naive and receiving alternative antipsychotics were recruited and completed a lifestyle, medication and infection-burden questionnaire. Serum total immunoglobulins (immunoglobulin (Ig)G, IgA, IgM) and specific IgG antibodies to haemophilus influenzae type B, tetanus and IgG, IgA and IgM to pneumococcus were measured.
Immunoglobulins were all significantly reduced in the clozapine-treated group (n = 123) compared with the clozapine-naive group (n = 111). Odds ratios (ORs) for a reduction in clozapine:control immunoglobulin values below the fifth percentile were IgG, OR = 6.00 (95% CI 1.31–27.44); IgA, OR = 16.75 (95% CI 2.18–128.60); and IgM, OR = 3.26 (95% CI 1.75–6.08). These findings remained significant despite exclusion of other potential causes of hypogammaglobulinaemia. In addition, duration on clozapine was associated with decline in IgG. A higher proportion of the clozapine-treated group reported taking more than five courses of antibiotics in the preceding year (5.3% (n = 5) versus 1% (n = 1).
Clozapine use was associated with significantly reduced immunoglobulin levels and an increased proportion of patients using more than five antibiotic courses in a year. Antibody testing is not included in existing clozapine monitoring programmes but may represent a mechanistic explanation and modifiable risk factor for the increased rates of pneumonia and sepsis-related mortality previously reported in this vulnerable cohort.
S.J. has received support from CSL Behring, Shire, LFB, Biotest, Binding Site, Sanofi, GSK, UCB Pharma, Grifols, BPL SOBI, Weatherden, Zarodex and Octapharma for projects, advisory boards, meetings, studies, speaker and clinical trials.
400 TW operation of Orion at ultra-high contrast
HPL_EP HEDP and High Power Laser 2018
Stefan Parker, Colin Danson, David Egan, Stephen Elsmere, Mark Girling, Ewan Harvey, David Hillier, Dianne Hussey, Stephen Masoero, James McLoughlin, Rory Penman, Paul Treadwell, David Winter, Nicholas Hopps
Journal: High Power Laser Science and Engineering / Volume 6 / 2018
Published online by Cambridge University Press: 15 August 2018, e47
The Orion facility at the Atomic Weapons Establishment in the United Kingdom has the capability to operate one of its two 500 J, 500 fs short-pulse petawatt beams at the second harmonic, the principal reason being to increase the temporal contrast of the pulse on target. This is achieved post-compression, using 3 mm thick type-1 potassium dihydrogen phosphate crystals. Since the beam diameter of the compressed pulse is ${\sim}600$ mm, it is impractical to achieve this over the full aperture due to the unavailability of the large aperture crystals. Frequency doubling was originally achieved on Orion using a circular sub-aperture of 300 mm diameter. The reduction in aperture limited the output energy to 100 J. The second-harmonic capability has been upgraded by taking two square 300 mm $\times$ 300 mm sub-apertures from the beam and combining them at focus using a single paraboloidal mirror, thus creating a 200 J, 500 fs, i.e., 400 TW facility at the second harmonic.
Water uncertainty, ritual predictability and agricultural canals at Chaco Canyon, New Mexico
Vernon L. Scarborough, Samantha G. Fladd, Nicholas P. Dunning, Stephen Plog, Lewis A. Owen, Christopher Carr, Kenneth B. Tankersley, Jon-Paul McCool, Adam S. Watson, Elizabeth A. Haussner, Brooke Crowley, Katelyn J. Bishop, David L. Lentz, R. Gwinn Vivian
Journal: Antiquity / Volume 92 / Issue 364 / August 2018
The Pueblo population of Chaco Canyon during the Bonito Phase (AD 800–1130) employed agricultural strategies and water-management systems to enhance food cultivation in this unpredictable environment. Scepticism concerning the timing and effectiveness of this system, however, remains common. Using optically stimulated luminescence dating of sediments and LiDAR imaging, the authors located Bonito Phase canal features at the far west end of the canyon. Additional ED-XRF and strontium isotope (87Sr/86Sr) analyses confirm the diversion of waters from multiple sources during Chaco's occupation. The extent of this water-management system raises new questions about social organisation and the role of ritual in facilitating responses to environmental unpredictability.
Utilizing Correlative, Multi-Technique Surface Analysis to Complement Microscopy Studies
Tim Nunney, Christopher Deeks, Paul Mack, Robin Simpson, Chris Stephens
Towards Atomic-Scale Fabrication in Silicon
Bethany M. Hudak, Stephen Jesse, Jiaming Song, Albina Borisevich, Paul C. Snijders, Sergei V. Kalinin, Andrew R. Lupini
5 - Radiation Therapy for Gynaecological Malignancies
By Christopher Stephen Kent, Paul Symonds
Edited by Mahmood Shafi, Helen Bolton, Ketankumar Gajjar
Book: Gynaecological Oncology for the MRCOG
Diagnostic errors in paediatric cardiac intensive care
Priya N. Bhat, John M. Costello, Ranjit Aiyagari, Paul J. Sharek, Claudia A. Algaze, Mjaye L. Mazwi, Stephen J. Roth, Andrew Y. Shin
Journal: Cardiology in the Young / Volume 28 / Issue 5 / May 2018
Diagnostic errors cause significant patient harm and increase costs. Data characterising such errors in the paediatric cardiac intensive care population are limited. We sought to understand the perceived frequency and types of diagnostic errors in the paediatric cardiac ICU.
Paediatric cardiac ICU practitioners including attending and trainee physicians, nurse practitioners, physician assistants, and registered nurses at three North American tertiary cardiac centres were surveyed between October 2014 and January 2015.
The response rate was 46% (N=200). Most respondents (81%) perceived that diagnostic errors harm patients more than five times per year. More than half (65%) reported that errors permanently harm patients, and up to 18% perceived that diagnostic errors contributed to death or severe permanent harm more than five times per year. Medication side effects and psychiatric conditions were thought to be most commonly misdiagnosed. Physician groups also ranked pulmonary overcirculation and viral illness to be commonly misdiagnosed as bacterial illness. Inadequate care coordination, data assessment, and high clinician workload were cited as contributory factors. Delayed diagnostic studies and interventions related to the severity of the patient's condition were thought to be the most commonly reported process breakdowns. All surveyed groups ranked improving teamwork and feedback pathways as strategies to explore for preventing future diagnostic errors.
Paediatric cardiac intensive care practitioners perceive that diagnostic errors causing permanent harm are common and associated more with systematic and process breakdowns than with cognitive limitations.
Copy Number Variation Analysis of 100 Twin Pairs Enriched for Neurodevelopmental Disorders
Sofia Stamouli, Britt-Marie Anderlid, Charlotte Willfors, Bhooma Thiruvahindrapuram, John Wei, Steve Berggren, Ann Nordgren, Stephen W. Scherer, Paul Lichtenstein, Kristiina Tammimies, Sven Bölte
Journal: Twin Research and Human Genetics / Volume 21 / Issue 1 / February 2018
Published online by Cambridge University Press: 08 January 2018, pp. 1-11
Hundreds of penetrant risk loci have been identified across different neurodevelopmental disorders (NDDs), and these often involve rare (<1% frequency) copy number variations (CNVs), which can involve one or more genes. Monozygotic (MZ) twin pairs are long thought to share 100% of their genomic information. However, genetic differences in the form of postzygotic somatic variants have been reported recently both in typically developing (TD) and in clinically discordant MZ pairs. We sought to investigate the contribution of rare CNVs in 100 twin pairs enriched for NDD phenotypes with a particular focus on postzygotic CNVs in MZ pairs discordant for autism spectrum disorder (ASD) using the Illumina Infinium PsychArray. In our sample, no postzygotic de novo CNVs were found in 55 MZ twin pairs, including the 13 pairs discordant for ASD. We did detect a higher rate of CNVs overlapping genes involved in disorders of the nervous system, such as a rare deletion affecting HNRNPU, in MZ pairs discordant and concordant for ASD in comparison with TD pairs (p = .02). Our results are in concordance with earlier findings that postzygotic de novo CNV events are typically rare in genomic DNA derived from saliva or blood, and suggests that the discordance of NDDs in our sample of twins is not explained by discordant CNVs. Still, studies investigating postzygotic variation in MZ discordant twins using DNA from different tissues and single cells and higher resolution genomics are needed in the future.
Ketamine in the Prehospital Environment: A National Survey of Paramedics in the United States
Daniel M. Buckland, Remle P. Crowe, Rebecca E. Cash, Stephen Gondek, Patrick Maluso, Sarah Sirajuddin, E. Reed Smith, Paul Dangerfield, Geoff Shapiro, Christopher Wanka, Ashish R. Panchal, Babak Sarani
Journal: Prehospital and Disaster Medicine / Volume 33 / Issue 1 / February 2018
Published online by Cambridge University Press: 21 December 2017, pp. 23-28
Use of ketamine in the prehospital setting may be advantageous due to its potent analgesic and sedative properties and favorable risk profile. Use in the military setting has demonstrated both efficacy and safety for pain relief. The purpose of this study was to assess ketamine training, use, and perceptions in the civilian setting among nationally certified paramedics (NRPs) in the United States.
A cross-sectional survey of NRPs was performed. The electronic questionnaire assessed paramedic training, authorization, use, and perceptions of ketamine. Included in the analysis were completed surveys of paramedics who held one or more state paramedic credentials, indicated "patient care provider" as their primary role, and worked in non-military settings. Descriptive statistics were calculated.
A total of 14,739 responses were obtained (response rate=23%), of which 10,737 (73%) met inclusion criteria and constituted the study cohort. Over one-half (53%) of paramedics reported learning about ketamine during their initial paramedic training. Meanwhile, 42% reported seeking ketamine-related education on their own. Of all respondents, only 33% (3,421/10,737) were authorized by protocol to use ketamine. Most commonly authorized uses included pain management (55%), rapid sequence intubation (RSI; 72%), and chemical restraint/sedation (72%). One-third of authorized providers (1,107/3,350) had never administered ketamine, with another 32% (1,070/3,350) having administered ketamine less than five times in their career. Ketamine was perceived to be safe and effective as the vast majority reported that they were comfortable with the use of ketamine (94%) and would, in similar situations (95%), use it again.
This was the first large, national survey to assess ketamine training, use, and perceptions among paramedics in the civilian prehospital setting. While training related to ketamine use was commonly reported among paramedics, few were authorized to administer the drug by their agency's protocols. Of those authorized to use ketamine, most paramedics had limited experience administering the drug. Future research is needed to determine why the prevalence of ketamine use is low and to assess the safety and efficacy of ketamine use in the prehospital setting.
Buckland DM , Crowe RP , Cash RE , Gondek S , Maluso P , Sirajuddin S , Smith ER , Dangerfield P , Shapiro G , Wanka C , Panchal AR , Sarani B . Ketamine in the Prehospital Environment: A National Survey of Paramedics in the United States. Prehosp Disaster Med. 2018;33(1):23–28.
Nomenclature for congenital and paediatric cardiac disease: the International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Iteration of the International Classification of Diseases (ICD-11)*
Rodney C. G. Franklin, Marie J. Béland, Steven D. Colan, Henry L. Walters, Vera D. Aiello, Robert H. Anderson, Frédérique Bailliard, Jeffrey R. Boris, Meryl S. Cohen, J. William Gaynor, Kristine J. Guleserian, Lucile Houyel, Marshall L. Jacobs, Amy L. Juraszek, Otto N. Krogmann, Hiromi Kurosawa, Leo Lopez, Bohdan J. Maruszewski, James D. St. Louis, Stephen P. Seslar, Shubhika Srivastava, Giovanni Stellin, Christo I. Tchervenkov, Paul M. Weinberg, Jeffrey P. Jacobs
Journal: Cardiology in the Young / Volume 27 / Issue 10 / December 2017
An internationally approved and globally used classification scheme for the diagnosis of CHD has long been sought. The International Paediatric and Congenital Cardiac Code (IPCCC), which was produced and has been maintained by the International Society for Nomenclature of Paediatric and Congenital Heart Disease (the International Nomenclature Society), is used widely, but has spawned many "short list" versions that differ in content depending on the user. Thus, efforts to have a uniform identification of patients with CHD using a single up-to-date and coordinated nomenclature system continue to be thwarted, even if a common nomenclature has been used as a basis for composing various "short lists". In an attempt to solve this problem, the International Nomenclature Society has linked its efforts with those of the World Health Organization to obtain a globally accepted nomenclature tree for CHD within the 11th iteration of the International Classification of Diseases (ICD-11). The International Nomenclature Society has submitted a hierarchical nomenclature tree for CHD to the World Health Organization that is expected to serve increasingly as the "short list" for all communities interested in coding for congenital cardiology. This article reviews the history of the International Classification of Diseases and of the IPCCC, and outlines the process used in developing the ICD-11 congenital cardiac disease diagnostic list and the definitions for each term on the list. An overview of the content of the congenital heart anomaly section of the Foundation Component of ICD-11, published herein in its entirety, is also included. Future plans for the International Nomenclature Society include linking again with the World Health Organization to tackle procedural nomenclature as it relates to cardiac malformations. By doing so, the Society will continue its role in standardising nomenclature for CHD across the globe, thereby promoting research and better outcomes for fetuses, children, and adults with congenital heart anomalies.
Primitive stalked echinoderms from the Middle Ordovician (Darriwilian) of Bang Song Tho, Kanchanaburi, western Thailand
CHRISTOPHER R.C. PAUL, ARTHUR J. BOUCOT, STEPHEN K. DONOVAN, REN-BIN ZHAN, WATTANA TANSATHIEN
Journal: Geological Magazine / Volume 156 / Issue 1 / January 2019
The Middle Ordovician (Darriwilian) echinoderm fauna of Bang Mueang Song Tho, western Thailand (Pha Phum group, Bo Ngam Formation(?)), includes rare thecae, and common thecal ossicles and columnals, and is dominated by 'cystoids'. Cheirocrinid glyptocystitoids include Cheirocystella sp. (= Echinoencrinites sp. aff. E. senckenbergii (von Meyer) sensu Wolfart), 'Cheirocrinus' sp. and Cheirocrinidae incertae sedis. Hemicosmitoids are composed of Paracaryocrinites kochi (Wolfart), 'Paracaryocrinites' sp. and Polycosmites sp. cf. P. kaekeli Wolfart. The aristocystitid Sinocystis sp. cf. S. loczyi Reed is the only diploporite. Columnals of Bystrowicrinus (col.) sp. are probably crinoidal. The fullest determination of the echinoderm biodiversity of this site has been obtained using all specimens from single ossicles to articulated thecae. The limited taphonomic data suggests that the echinoderm assemblage is parauthochthonous. Other echinoderms described from coeval deposits in this region include Stichocystis thailandica Wolfart; Heliocrinites sp. aff. H. qualus Bather (probably a Lophotocystis Paul); Gomphocystites? sp. indet. (= trilobite?); Codiacystis sp. aff. C. bohemicus (Barrande) (= bryozoan?); Aristocystis [sic] sp. A of Paul; and [non] Incertae sedis sp. C of Paul (may not be an echinoderm).
Genetic variation, Heritability estimates and GXE effects on yield traits of Mesoamerican common bean (Phaseolus vulgaris L) germplasm in Uganda
Dennis Okii, Clare Mukankusi, Sulaiman Sebuliba, Phinehas Tukamuhabwa, Geoffrey Tusiime, Herbert Talwana, Thomas Odong, Annet Namayanja, Pamela Paparu, Stanley Nkalubo, Michael Otim, Michael Ugen, Stephen Buah, Paul Gepts
Journal: Plant Genetic Resources / Volume 16 / Issue 3 / June 2018
Germplasm of common beans from the Mesoamerican gene pool races: Durango, Jalisco, Mesoamerica and Guatemala have highest genetic variation for the crop's improvement. The objective was to assign 50 common bean germplasm in Uganda into its gene pool races based on analyses of population structure. Secondly, to estimate heritability and effects of genotype × environment (GXE) interaction on common bean agronomic and yield traits in space and time. Sample genomic DNA was amplified in 2011 with 22 Simple sequence repeat markers (SSRs) and alleles separated using capillary electrophoresis. Field evaluations were conducted in 2010 and 2011 at NaCRRI and 2015 at CIAT – Kawanda. Multivariate analyses of SSRs data identified four subgroups within the germplasm: K4.1–K4.4, with corresponding Wrights fixation indices (FST) as 0.1829 for K4.1, 0.1585 for K4.4, 0.1579 for K4.2 and least for K4.3 at 0.0678. Gene pool race admixtures in the population (14%) were notable and attributed to gene flow. Four superior parents currently used in improving resistance to major diseases grouped as; Jalisco for MLB49-89A; Mesoamerica for MCM5001 and G2333; Durango for MEXICO 54. Heritability values for yield traits estimated using phenotypic data from above fixed parents, was above 0.81. Season and location had significant effect (P < 0.05) on numbers of: flower buds per inflorescence, pod formation and weight of 100 seeds. The findings will improve understanding of co-evolutionary relationships between bean hosts and pathogens for better disease management and will broaden the germplasm base for improving other tropical production constraints.
Fifty Years of Prefrontal Cortex Research: Impact on Assessment
Paul W. Burgess, Donald T. Stuss
Journal: Journal of the International Neuropsychological Society / Volume 23 / Issue 9-10 / October 2017
Our knowledge of the functions of the prefrontal cortex, often called executive, supervisory, or control, has been transformed over the past 50 years. After operationally defining terms for clarification, we review the impact of advances in functional, structural, and theoretical levels of understanding upon neuropsychological assessment practice as a means of identifying 11 principles/challenges relating to assessment of executive function. Three of these were already known 50 years ago, and 8 have been confirmed or emerged since. Key themes over this period have been the emergence of the use of naturalistic tests to address issues of "ecological validity"; discovery of the complexity of the frontal lobe control system; invention of new tests for clinical use; development of key theoretical frameworks that address the issue of the role of prefrontal cortex systems in the organization of human cognition; the move toward considering brain systems rather than brain regions; the advent of functional neuroimaging, and its emerging integration into clinical practice. Despite these huge advances, however, practicing neuropsychologists are still desperately in need of new ways of measuring executive function. We discuss pathways by which this might happen, including decoupling the two levels of explanation (information processing; brain structure) and integrating very recent technological advances into the neuropsychologist's toolbox. (JINS, 2017, 23, 755–767)
Ice-shelf basal channels in a coupled ice/ocean model
Carl V. Gladish, David M. Holland, Paul R. Holland, Stephen F. Price
A numerical model for an interacting ice shelf and ocean is presented in which the ice- shelf base exhibits a channelized morphology similar to that observed beneath Petermann Gletscher's (Greenland) floating ice shelf. Channels are initiated by irregularities in the ice along the grounding line and then enlarged by ocean melting. To a first approximation, spatially variable basal melting seaward of the grounding line acts as a steel-rule die or a stencil, imparting a channelized form to the ice base as it passes by. Ocean circulation in the region of high melt is inertial in the along-channel direction and geostrophically balanced in the transverse direction. Melt rates depend on the wavelength of imposed variations in ice thickness where it enters the shelf, with shorter wavelengths reducing overall melting. Petermann Gletscher's narrow basal channels may therefore act to preserve the ice shelf against excessive melting. Overall melting in the model increases for a warming of the subsurface water. The same sensitivity holds for very slight cooling, but for cooling of a few tenths of a degree a reorganization of the spatial pattern of melting leads, surprisingly, to catastrophic thinning of the ice shelf 12 km from the grounding line. Subglacial discharge of fresh water along the grounding line increases overall melting. The eventual steady state depends on when discharge is initiated in the transient history of the ice, showing that multiple steady states of the coupled system exist in general.
Exposure to air pollution and tobacco smoking and their combined effects on depression in six low- and middle-income countries
Hualiang Lin, Yanfei Guo, Paul Kowal, Collins O. Airhihenbuwa, Qian Di, Yang Zheng, Xing Zhao, Michael G. Vaughn, Steven Howard, Mario Schootman, Aaron Salinas-Rodriguez, Alfred E. Yawson, Perianayagam Arokiasamy, Betty Soledad Manrique-Espinoza, Richard B. Biritwum, Stephen P. Rule, Nadia Minicuci, Nirmala Naidoo, Somnath Chatterji, Zhengmin (Min) Qian, Wenjun Ma, Fan Wu
Journal: The British Journal of Psychiatry / Volume 211 / Issue 3 / September 2017
Little is known about the joint mental health effects of air pollution and tobacco smoking in low- and middle-income countries.
To investigate the effects of exposure to ambient fine particulate matter pollution (PM2.5) and smoking and their combined (interactive) effects on depression.
Multilevel logistic regression analysis of baseline data of a prospective cohort study (n=41785). The 3-year average concentrations of PM2.5 were estimated using US National Aeronautics and Space Administration satellite data, and depression was diagnosed using a standardised questionnaire. Three-level logistic regression models were applied to examine the associations with depression.
The odds ratio (OR) for depression was 1.09 (95% CI 1.01–1.17) per 10 μg/m3 increase in ambient PM2.5, and the association remained after adjusting for potential confounding factors (adjusted OR = 1.10, 95% CI 1.02–1.19). Tobacco smoking (smoking status, frequency, duration and amount) was also significantly associated with depression. There appeared to be a synergistic interaction between ambient PM2.5 and smoking on depression in the additive model, but the interaction was not statistically significant in the multiplicative model.
Our study suggests that exposure to ambient PM2.5 may increase the risk of depression, and smoking may enhance this effect.


There's nothing wrong with that, of course. She's my chief nurse, it's icy, and I've been known to be a bit clumsy on the crutches lately. But not going anywhere all… day… long… depresses me under the very best circumstances. Which these are not.
I shook myself and forced a long introspective talk about how this is seriously unhealthy behavior. I promised myself that I would NOT have another day like that. At the conclusion of this little talk, I vowed that today I would be super productive!
* have brilliant physical therapy session (I went! I was a little late! not brilliant!).
Looking over this, it hardly seems productive at all. Good thing I set the bar so amazingly low yesterday that, by comparison, it's just fine.
I'll keep that one tucked… er.. I mean, filed away.


I love the fall, don't you? It's that magical time of the year when the hottest of the summer weather is gone, but the coldest of the winter weather is yet to hit. It leaves you with lots of time to partake in some specifically seasonal activities! You should definitely spend time doing 'things' until it gets too cold and harsh and you close yourself away and wait for Christmas to come! Here is the best fall activity for your zodiac sign.
You love to gear up to something and prepare, so you should spend your time coming up with and putting together the perfect Halloween costume!
Killers, Deception and Spies…Oh My!


Send your deepest condolescences to a loved one with our "Peace Planter" which includes the elegant calla lily. This type of planter is traditionally used at a loved one's funeral, or for the family's home. Wherever it may be placed, knowing that the array of evergreen plants will last even after the service, is settling.


text:
void SyncWorker::create_loop( const size_t loop_time ,
                              const syncworker_callback_t callback ,
                              void * data )
{
    SyncWorker* worker = new SyncWorker();
    worker->callback_ = callback;
    worker->loop_time_ = loop_time;
    worker->data( data );
    worker->start();
}

void SyncWorker::create_once( const syncworker_callback_t callback ,
                              void * data )
{
    SyncWorker* worker = new SyncWorker();
    worker->callback_ = callback;
    worker->loop_time_ = 1;
    worker->data( data );
    worker->finished = true;
    worker->start();
}

void SyncWorker::stop()
{
    this->finished = true;
}

void SyncWorker::uv_process_timer_tick_callback( uv_timer_t * handle )
{
    SyncWorker* inst = static_cast< SyncWorker* >( handle->data );

    if ( inst == nullptr )
    {
        uv_timer_stop( handle );
        return;
    }

    inst->callback_( inst );

    ++inst->loop_count_;

    if ( inst->finished )
    {
        uv_timer_stop( &inst->timer_ );
        SAFE_DELETE( inst );
    }
}

SyncWorker::SyncWorker()
{
    this->timer_ = { 0 };
    this->timer_.data = this;
    this->loop_count_ = 1;
    this->loop_time_ = 1;
    uv_timer_init( uv_default_loop() , &this->timer_ );
}

SyncWorker::~SyncWorker()
{
}

void SyncWorker::start()
{
    uv_timer_start( &this->timer_ , SyncWorker::uv_process_timer_tick_callback , 0 , this->loop_time_ );
}

redpajama_set_name: RedPajamaGithub


The Ministry of Health in Angola has reported an ongoing outbreak of yellow fever. At least 3,552 suspected and confirmed cases have been reported nationally, including 355 deaths. The majority of yellow fever cases and deaths have been in Luanda Province. However, cases have been reported throughout the country. The Ministry is working with the World Health Organization to control the outbreak and has been conducting an emergency vaccination campaign.
The government of Angola requires all travelers older than 9 months of age to show proof of yellow fever vaccination upon arrival. In addition, the Centers for Disease Control and Prevention (CDC) recommends that all travelers to Angola aged 9 months or older be vaccinated against yellow fever.
People who have never been vaccinated against yellow fever should not travel to Angola. Since there is currently a shortage of yellow fever vaccine(http://wwwnc.cdc.gov/travel/news-announcements/yellow-fever-vaccine-shortage-2016), travelers may need to contact a yellow fever vaccine provider well in advance of travel. CDC no longer recommends booster doses of yellow fever vaccine for most travelers. However, Angola is currently a higher-risk setting because of the outbreak, so travelers to Angola may consider getting a booster if their last yellow fever vaccine was more than 10 years ago. For more information, see http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6423a5.htm.
Yellow fever is a disease caused by a virus, which is spread through mosquito bites. Symptoms take 3–6 days to develop and include fever, chills, headache, backache, and muscle aches. About 15% of people who get yellow fever develop serious illness that can lead to bleeding, shock, organ failure, and sometimes death.
Travelers can protect themselves from yellow fever by getting yellow fever vaccine and preventing mosquito bites.
Visit a yellow fever vaccination (travel) clinic(http://wwwnc.cdc.gov/travel/yellow-fever-vaccination-clinics/search.htm) and ask for a yellow fever vaccine.
You should receive this vaccine at least 10 days before your trip.
After receiving the vaccine, you will receive a signed and stamped International Certificate of Vaccination or Prophylaxis(http://wwwnc.cdc.gov/travel/yellowbook/2016/infectious-diseases-related-to-travel/yellow-fever#4735) (ICVP, sometimes called the "yellow card"), which you must bring with you on your trip.
For most travelers, one dose of the vaccine lasts for a lifetime. Consult a travel medicine provider to see if additional doses of vaccine may be recommended for you based on specific risk factors.
In rare cases, the yellow fever vaccine can have serious and sometimes fatal side effects. People older than 60 years and people with weakened immune systems might be at higher risk of developing these side effects. Also, there are special concerns for pregnant and nursing women. Talk to your doctor about whether you should get the vaccine.
Cover exposed skin by wearing long-sleeved shirts and pants.
Use an EPA-registered insect repellent containing DEET, picaridin, oil of lemon eucalyptus (OLE), or IR3535. Always use as directed.
If you are also using sunscreen, apply sunscreen first and insect repellent second.
Most repellents, including DEET, can be used on children aged >2 months.
Follow package directions when applying repellent on children. Avoid applying repellent to their hands, eyes, and mouth.
Treated clothing remains protective after multiple washings. See the product information to find out how long the protection will last.
If treating items yourself, follow the product instructions carefully.
Do not use permethrin directly on skin.
Stay and sleep in screened or air conditioned rooms.


Cox's proportional hazards model is by far the most common approach used to model survival or time to event data. For a simple two group comparison, such as in a randomised controlled trial, the model says that the hazard of failure in one group is a constant ratio (over time) of the hazard of failure in the other group. A test that this hazard ratio equals 1 is a test of the null hypothesis of equality of the survival functions of the two groups. The log rank test is essentially equivalent to the score test that the HR=1 in the Cox model, and is commonly used as the primary analysis hypothesis test in randomised trials.
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