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Everolimus as adjunctive treatment in tuberous sclerosis complex-associated epilepsy in children
Eva Martha Madsen Svarrer1, Claudia Maria Fischer2, Mikkel Grenaa Frederiksen2, Alfred Peter Born2 & Christina Engel Hoei-Hansen2 1) Department of Paediatrics, North Zealand Hospital Hilleroed2) Department of Paediatrics, Rigshospitalet, Denmark
Dan Med J 2019;66(12):A5582
Tuberous sclerosis complex (TSC) is an autosomal dominant disease, which in Denmark has an estimated incidence of approximately 5-10/year and a prevalence of 200-400 cases [1, 2]. It is a multi-organ disease with highly variable comorbidity [2]. A history of seizures has been reported in up to 85% of patients. Seizure onset is often seen in the first years of life and up to two-thirds of patients are refractory to antiepileptic medication (AED). Infantile spasms or focal-onset seizures are common seizure types and epilepsy is associated with an increased risk of neuro-developmental disorders like autism spectrum disorder and intellectual disability.
INTRODUCTION: Tuberous sclerosis complex (TSC) is a rare autosomal dominant multi-organ disease. In TSC, epilepsy is frequent and often treatment refractory. Dysfunction of the tumour-suppressing hamartin/tuberin complex leads to an over-activated mammalian target of rapamycin (mTOR) signalling pathway and uncontrolled cell growth. Protocolled treatment of TSC-associated epilepsy with the mTOR inhibitor everolimus has recently been approved by The Danish Medicines Council in Denmark.
METHODS: Clinical data on the first Danish paediatric patients treated with everolimus for epilepsy and a review of the literature are presented.
RESULTS: Four patients met the inclusion criteria and had been treated for more than 12 months. Onset of epilepsy was at a median age of 1.1 years (range: 0.3-3.3 years) and current age was 3.4 years (range: 2.2-7.4 years). The previous median number of antiepileptic drugs was 5.0 (range: 2-10) and the concomitant median number of antiepileptic drugs was 2.5 (range: 1-4). Several other treatment modalities had been or were still being applied, including ketogenic diet (n = 3), vagus nerve stimulation (n = 1) and epilepsy surgery (n = 2). The number of focal seizures was in the 20-160 range per week before everolimus. All patients had a > 50% seizure reduction after 12 months of everolimus treatment. One patient became seizure free. Side effects were mild and self-limiting.
CONCLUSIONS: Early data on everolimus as an adjunctive treatment in TSC-associated epilepsy are promising with regards to both effect and tolerability.
Other TSC manifestations include benign tumours in organs such as the kidneys, brain, heart and skin. The most frequent tumours are renal angiomyolipomas, which are seen in approximately 70% of patients, who also often have cysts and renal functional impairment [3]. Additionally, a benign glioneuronal brain tumour, the subependymal giant astrocytoma, develops in 20% of TSC patients. These patients may have symptoms of increased intracranial pressure due to localisation at the foramen Monroi. Furthermore, in a subset of women with TSC, symptomatic lymphangioleiomyomatosis may evolve, a condition characterised by cystic destruction of the lungs with chylous pleural effusion [2]. The care and follow-up of patients with TSC is multidisciplinary and complex.
TSC is caused by mutations in either the TSC1 gene on chromosome 9 or the TSC2 gene on chromosome 16. In 10-15%, the genetic aetiology escapes detection and diagnosis is based on clinical criteria [4]. Overall, two-thirds of cases result from de novo variants. The variants cause dysfunction of the tumour-suppressing hamartin/tuberin complex that leads to an over-activated mammalian target of rapamycin (mTOR)-signalling (mechanistic target of rapamycin) pathway, resulting in proliferation, angiogenesis and uncontrolled cell growth (Figure 1). For many years, mTOR inhibitor treatment has been indicated for treatment of adult TSC patients with renal angiomyolipomas, lymphangioleiomyomatosis and for cerebral subependymal giant astrocytomas in both adults and children [5, 6].
Recent data suggest that treatment with the mTOR inhibitor everolimus is also effective in the treatment of focal-onset epilepsy. Therefore, protocolised treatment of TSC-associated epilepsy with everolimus was approved in 2017 by The Danish Medicines Council. A review of the literature and the progress in the treatment of our first paediatric patients is described herein.
Treatment protocol
Patients were followed at the tertiary neuropaediatric centre at Rigshospitalet by neuropaediatricians CHH or PB and epilepsy nurse CF. Upon approval by The Danish Medicines Council, the patients were screened to validate that they fulfilled starting criteria: a) TSC diagnosis based on clinical or genetic criteria, b) drug-resistant epilepsy based on the criteria from the International League Against Epilepsy, c) non-pharmacological treatment having been considered, including epilepsy surgery, vagus nerve stimulation or a ketogenic diet, d) weekly seizures with substantial impact, d) no contraindications to everolimus, e) expected good compliance. The stop criteria were: a) seizure reduction of less than 33% after four months of adequate serum levels of everolimus, b) seizure reduction of less than 50% after 12 months, c) intolerable adverse events. Drug-resistant epilepsy was therefore defined as failure of adequate trials of two tolerated, appropriately chosen and used antiepileptic drug schedules (whether as monotherapies or in combination) to achieve sustained seizure freedom. The inclusion criteria for the present study were 1) age below 18 years, 2) tuberous sclerosis complex fulfilling either clinical or genetic criteria [3], 3) eligible for everolimus for epilepsy, based on Danish Medicines Council criteria.
Treatment followed recommendations by the manufacturer and experiences made by others [7]. Dosing of the everolimus (Votubia) dispersible tablets was initiated with careful titration as doses that are effective and well-tolerable vary between patients. The starting dose was 5-9 mg/m2, higher in younger children and if the patients were also being treated with a CYP3A4/PgP inducer. The patients were followed with general annual TSC evaluation consisting of cerebral magnetic resonance imaging (MRI), ultrasound or MRI of the kidneys, ophthalmological and cardiological examination. Prior to treatment and at regular 4-12-week intervals depending on patient tolerability, blood pressure and blood samples were analysed including a full blood count, renal and liver function, fasting glucose and lipid profile. Serum levels of everolimus were analysed after two, six and ten weeks, and when stable every three to six months. Families provided a weekly seizure diary. Adverse events were monitored closely and handled as suggested by Davies et al [7]. In general, the families were advised to seek medical advice in all cases of febrile illness or suspicion of side effects. Everolimus was paused in case of infection and dosage was reduced or stopped in case of adverse events.
Patient characteristics
Four paediatric patients at Rigshospitalet met the criteria for everolimus treatment and have been treated for more than 12 months (Table 1). Consent to publication from parents to all patients was obtained. Evaluation of medical records was performed in March 2019.
Epilepsy treatment prior to everolimus
The patients with treatment-resistant epilepsy and TSC who were treated with everolimus were two girls and two boys with a median age of 3.4 years (range: 2.2-7.4; Table 1) at the time of data extraction. Onset of epilepsy occurred at a median age of 1.1 years (range: 0.3-3.3 years). The patients had been treated for a period of 0.8 to 2.8 years prior to initiation of everolimus (Figure 2). The previous number of AEDs was 5.0 (range: 2-10) and the concomitant current number of AEDs was 2.5 (range: 1-4). One patient had been treated with hydrocortisone for infantile spasms and one patient was being treated with cannabidiol. A ketogenic diet was applied for three patients, of whom two had stopped due to insufficient response. Other concomitant or previous treatment modalities included a nervus vagus stimulator in one patient (patient two treated prior to and during the entire period with everolimus treatment) and epilepsy surgery in two patients, of whom one had a treatment response of Engel class IV (patient one had epilepsy surgery at the age of ten months and had no significant seizure reduction after surgery) and one Engel class II (patient three had epilepsy surgery at the age of two years and six months and thereafter only rarely had disabling seizures – everolimus was initiated three months before surgery).
Other tuberous sclerosis complex manifestations
The genetic aetiology for TSC was a pathogenic variant in the TSC2 gene in 3/4 patients. In the final patient, no variant was detected by sequencing of the TSC1 gene and the TSC2 gene, but the patient met the clinical criteria for TSC [2]. In addition to treatment-resistant epilepsy, the patients had other neurological TSC manifestations of delayed development (4/4), autism (1/4) and attention deficit hyperactivity disorder (1/4). No patients had a subependymal giant cell astrocytoma. Other manifestations and symptoms included cardiac rhabdomyoma (2/2), renal angiomyolipoma (4/4), hypertension (1/4) and ungual angiofibroma (1/4).
Everolimus treatment
Initiation of everolimus occurred at a median age of 2.7 years (range: 1.2-6.1 years). Prior to treatment, the patients had 20-160 weekly focal seizures with impaired awareness. One patient also had more than 50 absences daily, which some days were equivalent to absence status epilepticus. Time to reach target level of p-everolimus levels of 5-15 ng/ml was 44-72 days (median 57 days). After having reached this level, the patients had several shorter periods with levels below target due to drug interactions and/or pausing of everolimus because of neutropenia (Figure 2). None of the patients reached a stop criterion with regard to the seizure control. Patient 1 had reduction of the number of weekly focal seizures with impaired awareness from 140 per week prior to everolimus to 58 and 66 per week after four and 12 months, respectively. Patient 2 experienced a reduction in focal seizures from 30 per week prior to everolimus to 15 per week, and the multiple absences were absent after 12 months of treatment. Patient 3 experienced 20 focal seizures per week prior to treatment and had concomitant epilepsy surgery at the time of everolimus initiation due to severe deterioration of development due to seizures. In the 12 months after everolimus initiation, the patient had none of the previous focal seizures but on two occasions the patient during fever and infection had status epilepticus. Patient 4 had 160 focal seizures per week prior to everolimus and has become seizure free at the time of data extraction – and has remained without seizures for a period of 15 months (Table 1). Adverse events were mild and self-limiting and included exanthema, stomatitis, diarrhoea and neutropenia. All families reported positive psychomotor development.
Since protocolled treatment with mTOR inhibitor everolimus of treatment-resistant epilepsy in patients with TSC became possible in Denmark in 2017, a total of ten patients have initiated treatment. Four of these patients have been treated more than 12 months and the results for these patients are presented here. The patients were young and had been treated with multiple drugs and non-pharmacological approaches prior to everolimus initiation. They had many seizures weekly and all fulfilled the criterion that was a requirement from The Danish Medicines Council, i.e., that a more than 50% seizure reduction was seen after 12 months of treatment. The effect of everolimus on our patients is described. Nevertheless, it should be taken into account that the patients had other concomitant modalities, which continued, were adjusted for or initiated during the course of everolimus treatment. To which degree the treatment effect is, in fact, owed to everolimus is difficult to ascertain. Adverse events were mild and self-limiting, and families experienced a positive effect on psychomotor development.
The first papers on everolimus with a focus on epilepsy were the case series by Wiegand et al [8] and the phase 1/2 study by Krueger et al [9]. The highest degree of evidence was contributed by the EXIST-3 study, which was a randomised, double-blind phase 3 multicentre study describing adjunctive everolimus in TSC patients with refractory epilepsy. The patients received 1-3 AEDs and were randomised to low (3-7 ng/ml) or high (9-15 ng/ml) serum levels of everolimus or placebo. The median age was 10.1 years. The median seizure frequency prior to treatment was 35, 38 and 42 seizures per 28 days, respectively. There was a significant seizure reduction with median seizure reduction rates of 29.3% and 39.6% as compared to 14.9% in the placebo arm after 18 weeks of treatment [10].
A long-term effect was described by Krueger et al in the 2016 extension study of the prospective, open-label study by Krueger et al from 2013. Participants with effect in the initial study were followed for 48 months and of the 14 who were treated for the full period, 13 reported a > 50% reduction in seizure frequency [11]. Extension data from the EXIST-3 study have recently been published, describing 366 patients in the extension phase [12]. At weeks 42, 54 and 66 of treatment, the median seizure reduction was 42.2%, 41.3% and 43.5%, respectively, as compared with baseline. The safety and tolerability for patients receiving everolimus for epilepsy was similar to that for patients receiving everolimus for benign tumours. In the EXIST-3, the most frequently reported adverse events were stomatitis, diarrhoea, mouth ulceration, nasopharyngitis, upper respiratory tract infection and fever. Discontinuations due to adverse events were low in the EXIST-3 study, where adverse events causing treatment discontinuation were seen in two (2%) patients in the placebo group versus six (5%) in the low-exposure group and four (3%) in the high-exposure group. Hyperlipidaemia and neutropenia were the most frequent adverse events in blood. Standard recommendations therefore suggest that everolimus be paused during infection and do not advise concomitant treatment with a ketogenic diet. In one of our patients, neutropenia occurred frequently even during mild infections and in another patient a ketogenic diet was also used, but lipids remained at the same levels as before everolimus. The response rate with a ≥ 50% reduction after one year of treatment was 46.6% (n = 298 patients completed this length of treatment), and 57.7% (n = 163) at two years. In this very long-term follow-up, more adverse events were seen. The incidence of grade 3 and 4 adverse events was 40.2% and 13% of patients discontinued due to an adverse event. Two deaths were suspected to be treatment-related (pneumonia and septic shock).
In a recent publication, focus was on very young children who were not included in the EXIST-3 study.
A total of 45 patients with a median age of 16.1 months were treated with either everolimus (87%) or sirolimus (24%). Indication for treatment was refractory epilepsy in 45%. For all indications, 29/45 (64%) reported at least partial benefit. Treatment was discontinued due to an adverse effect in 20% [13].
Other smaller series and case reports have been published reporting findings comparable to those of the larger series [14-19] (Table 2). With regard to quality of life, there are indications of improved quality of life with increased seizure control [20].
Early data on everolimus as an adjunctive treatment in TSC-associated epilepsy is promising with regards to both effect and tolerability. Protocolised treatment or close monitoring of efficacy and side effects is warranted.
CORRESPONDENCE: Christina Engel Hoei-Hansen. E-mail: chh@dadlnet.dk
ACCEPTED: 1 November 2019
DMJ 12/2019
Hansen JB. At leve med tuberøs sclerose. Copenhagen: Forlaget Center for Små Handikapgrupper, 2005.
Henske EP, Jóźwiak S, Kingswood JC et al. Tuberous sclerosis complex. Nat Rev Dis Primer 2016;2:16035.
Eijkemans MJC, van der Wal W, Reijnders LJ et al. Long-term follow-up assessing renal angiomyolipoma treatment patterns, morbidity, and mortality: an observational study in tuberous sclerosis complex patients in the Netherlands. Am J Kidney Dis 2015;66:638-45.
Northrup H, Krueger DA, the International tuberous sclerosis complex consensus group. Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 International tuberous sclerosis complex consensus conference. Pediatr Neurol 2013;49:243-54.
Bissler JJ, Kingswood JC, Radzikowska E et al. Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet 2013;381:817-24.
Franz DN, Belousova E, Sparagana S et al. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet 2013;381:125-32.
Davies M, Saxena A and Kingswood JC. Management of everolimus-associated adverse events in patients with tuberous sclerosis complex: a practical guide. Orphanet J Rare Dis 2017;12:35.
Wiegand G, May TW, Ostertag P et al. Everolimus in tuberous sclerosis patients with intractable epilepsy: a treatment option? Eur J Ped Neurol 2013;17:631-8.
Krueger DA, Wilfong AA, Holland-Bouley K et al. Everolimus treatment of refractory epilepsy in tuberous sclerosis complex. Ann Neurol 2013;74:679-87.
French JA, Lawson JA, Yapici Z et al. Adjunctive everolimus therapy for treatment resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3). Lancet 2016;388:2153-63.
Krueger DA, Wilfong AA, Mays M et al. Long-term treatment of epilepsy with everolimus in tuberous sclerosis. Neurology 2016;87:2408-15.
Franz DN, Lawson J, Yapici Z et al. Everolimus for treatment-refractory seizures in TSC: Extension of a randomized controlled trial. Neurol Clin Pract 2018;8:412-20.
Krueger DA, Capal JK, Curatolo P et al. Short-term safety of mTOR inhibitors in infants and very young children with tuberous sclerosis complex (TSC): Multicentre clinical experience. Eur J Ped Neurol 2018;22:1066-73.
Perek-Polnik M, Jóźwiak S, Jurkiewicz E et al. Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous
sclerosis complex. Eur J Ped Neurology 2012;1:83-5.
Kilincaslan A, Kok BE, Tekturk P et al. Beneficial effects of everolimus on autism and attention-deficit/hyperactivity disorder symptoms in a group of patients with tuberous sclerosis complex. J Child Adolesc Psychopharmacol 2017;27:383-8.
Wiemer-Kruel A, Woerle H, Strobl K et al. Everolimus for the treatment of subependymal giant cell astrocytoma probably causing seizure aggravation in a child with tuberous sclerosis complex: a case report. Neuropediatrics 2014;45:129-31.
Wheless JW. Use of the mTOR inhibitor everolimus in a patient with multiple manifestations of tuberous sclerosis complex including epilepsy. Epilepsy Behav Case Rep 2015;4;63-6.
Flores-González JC, Estalella-Mendoza A, Lechuga-Sancho AM et al. Severe pneumonia by mycoplasma as an adverse event of everolimus therapy in patients with tuberous sclerosis complex. Eur J Ped Neurol 2016;20:758-60.
Samueli S, Abraham K, Dressler A et al. Efficacy and safety of everolimus in children with TSC - associated epilepsy - Pilot data from an open single-center prospective study. Orphanet J Rare Dis 2016;11:145.
De Vries PJ, Franz DN, Curatolo P et al. Measuring health-related quality of life in tuberous scerosis complex. Front Pharmacol 2018;9:964.


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Mitigation condition held contrary to regulations
A planning condition intended to ensure mitigation of adverse impacts on protected habitats arising from a proposal for a bungalow in a village on the Hampshire coast has been ruled out by an inspector.
The site lay in a large village near the New Forest National Park. The inspector agreed that adverse effects arising from increased recreational pressure on SPAs, SACs, and Ramsar sites could not be ruled out. The council sought to secure a funding contribution towards mitigation through a negatively worded condition and a post-approval section 106 agreement, in order to sidestep the pooling restrictions in the Community Infrastructure Levy (CIL) Regulations.
In the inspector's opinion, the condition served to require the appellant to enter into a planning obligation, which would be at odds with Planning Practice Guidance, and anticipated contributions towards relevant infrastructure, which would conflict with the CIL regulations. The council pointed out that that the appellant had agreed to accept the condition and that similar conditions had been supported by other inspectors. The inspector found the reasoning in the other cases cited sufficiently detailed to justify departures from national guidance.
The inspector found no harm in respect of the bungalow's impact on the area's character and appearance or on living conditions. Although a proposal for a two-storey house on the site had recently been dismissed on appeal, he was satisfied that the reduced scale, design and detailing of the bungalow would be in keeping with the area and occupants' privacy would be secured by boundary planting.
Inspector: Benjamin Webb; Written representations
Automatic ventilation system accepted on quiet industrial estate
Plot subdivision designed to preserve area character
Sustainable homes judged an overdevelopment of village site
Emergency evacuation risk scuppers plans for flat
Covid impact played down in greenfield homes refusal

redpajama_set_name: RedPajamaCommonCrawl


Every first Thursday and third Sunday of the month. See program details.
Be part of a great walking club in Sydney!
Meetup twice a week with our walking club. We offer long easy, medium or long walking tracks. Our meeting places in Sydney vary, so please ensure you check with DOOLEYS for more information.
Want to know more about our Sydney walking group meetup schedule, please see below for more information. If you have any questions, please contact DOOLEYS Member Services on 8745 6105.


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Yawn, an easy, free real lifehack, how to make it WOW!
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I injured my neck and finally went to a chiropractor. The x-rays showed a crack in a vertebrate, after exhausting my insurance visits and some out of pocket visits to the chiropractor I had about 75% pain relief, most of the time. My wife saw a demo of the Tuner from Sharik and came home from work telling me that we needed to buy one. Looking at the cost of a Tuner versus what I had spent at the chiropractor, and the pain I still had, I decided it was worth a try. After receiving the Tuner, my wife applied it around the neck injury for five to ten minutes before bedtime. When I awoke the following morning my neck naturally popped twice and I felt a great deal of pain relief. I continued to use it for the following three weeks, once per day before bed. I can actually turn my head to back a car up. My neck feels so much better. This was a big deal. My lower back, shoulder and knee has also felt a great deal of relief from this product. The Rezzimax Tuner has made such a difference in my life, I don't know what I'd do without it.
Fishing with the greatest gifts of all, my grandchildren.
I have had Trigeminal Neuralgia for 23 Years. The severe pains generated by these nerves are located on the left side of my face mostly above and in my left eye. I met Mr. Peck in the summer of 2016 when I was experiencing an attack about every 5 minutes with duration of approximately 90 seconds. Mr. Peck introduced me to a new treatment tool called the Tuner. If I understand its working concept, the Tuner attempts to bring the vibrations of your body in alignment. I use the Tuner to drive the pain out of my face. (I haven't decided yet how much the humming works as I am off tune and mostly a groan) Mr. Peck also teaches the use of a Sander/buffer to help blood circulation. I call it; "wax on wax off". The tool is a simple car buffer. It has helped my shoulders, hands and feet feel better. My wife used the buffer to treat diabetic neuropathy in her feet and legs. I watched the color of her feet change from purple to flesh color again, it was very impressive.
Between the two tools, I get relief from the most severe attacks; this allows me to continue with one of my favorite activities, FISHING with the greatest gifts of all, my grand children.
The following steps are to be done simultaneously while following the main techniques. Be sure to try each technique for 30-60 seconds at each location.
Sit or lie down in a comfortable position and loosen your jaw muscles by placing the tip of your tongue between your front teeth.
Hum to the resonance you feel from the Tuner – imagine humming into a fan. This will create a "tuning" effect which synchronizes your nervous system with the tool.
Identify any negative thought and immediately replace it with seven positive thoughts. This exercise of the mind literally changes your brain chemistry and sets you up for immediate and successful relief.
I remember my very first shock with trigeminal neuralgia. It was a Saturday morning; I was taking a bath getting ready for church. As I was washing my face, for the first time in my life I felt an excruciating pain as I washed the left side of my face. Radiating along my jaw line. I didn't think much of it and went about my day as usual. Then it happened again; unbearable pain at the touch of my toothbrush against my teeth. I thought, what the heck. Monday at work the pain of innumerable shocks affected my day. I called my dentist I was sure I was in the need of some serious dental work. After a thorough exam, my dentist handed me a piece of paper with the words that would forever change my life written in casual black ink: Trigeminal Neuralgia. He handed it to me and said go home and look it up on the Internet. I went back to work. One of my coworkers when I said the unspeakable that my dentist thought I had "trigeminal neuralgia" said; " I feel really sorry for you, I used to volunteer at a TN workgroup and it is the worst pain imaginable, its called the suicide disease". Really, I thought, you don't know me and I don't do chronic pain.
"Mom you're drooling". I was in severe pain; yet I could not feel the drool running out of my mouth. I was horrified, and went back to the neurologist (my third specialist). They tried giving me injections into my skull that at first I thought wasn't too bad, but within the hour I could not even drive myself home.
When after failed success with the medications, injections, and advice to have surgery, a friend told me about a naturopathy doctor that they had success with. When leaving their house that night I asked my husband what he thought about the naturopaths, he thought it was ridiculous, but I said I wanted to give it a try.
My first visit with the naturopath was somewhat disappointing. She sent me back to my neurologist to be weaned off my prescription medications. My treatments with Jenny began three times a week, and then gradually lessened as my symptoms improved. I was able to return to work as an RN. I thought I had beaten this trial and had successfully put it behind me.
Then a few years later the pain returned. Again I sought treatment from a dentist. After having all my amalgam filling removed, four crowns and two root canals later, I had won again.
When I would have small flair ups I would treat myself with my EFS 100 that we had purchased, I took phosphatidyl serene supplements, used a cool laser, and vitamins. Then I found Therapeutic Grade Certified Pure Essential Oils. This had finally begun helping my TN pain. I was so happy, and still in denial that I had a real problem, even after eight years of suffering.
The winter of 2015 when we took a travel assignment in California I began having pain again. I used my supplements, used my cool laser, my EFS, and essential oils with no success. I was sure I had a problem with my teeth and after six weeks of suffering got myself a dentist appointment with a holistic dentist. After a thorough exam she said to me my teeth where fine and I needed to see my doctor about my TN. January 15, 2016, this was the day I finally accepted I had trigeminal neuralgia, this was a real chronic condition that I might not be able to fix. Would my husband love me through this unbearable pain, would my kids think less of me, would my coworkers think I was still a good nurse, would my friends, still like me; this was the day I accepted the imperfect me!
That may sound so cliché and easy but trust me it came with yelling, hatred, and lots and lots of tears and praying, God help me through this. You see imperfection is not something that comes easy to me. This reality was brought to my attention one year when my then great nephew at about the age of five was making Valentine cookies with his grandma, my sister. He said to her" this cookie is for Aunt Betty because its perfect and she likes everything perfect". The wisdom of a child was an eye opener to me, I was, or still am a perfectionist.
The pain I was in was so excruciating. I compared it to grabbing big electric power lines. The pain would literally knock me to my feet. I couldn't eat, I couldn't sleep, couldn't brush my teeth, wash my face, I could not go out socially with friends for fear they would see the pain, and chewing food was impossible. The worst part for me was I couldn't even kiss my husband. I was put back on large doses of anti- convulsants, muscle relaxers, pain medications, and now also anti nausea medication because all the other medications where making me sick.
Again I went to neurologist, acupuncturist, chiropractor, massage therapists, and Chinese medicine doctor trying to get relief. I got some relief but still had limited pain free moments.
It was in September 2016 that I found Sharik Peck and I watched as he demonstrated the Tuner. I was very skeptical but desperate to try anything. I talked with Sharik, explained my story, and tried the Tuner. I wasn't immediately sold. But remember I was on large doses of medications. A few weeks later I bought the Tuner. At first I could use it only on my feet & legs, any closer would induce the TN shocks. But the more I used the Tuner, the better I began to feel. I had spent thousands of dollars trying to find relief and found it in the affordable Tuner.
Then in July 2017 I was able to be off all my prescription medications and be totally pain free! After 19 months of suffering I was free! Free of medications, free of pain, free to be me. Free to be a wife, a mom, a nurse, a friend, and now also a grandma. Words cannot express the gratitude I feel for Sharik for inventing the Tuner, but for also answering all my emails and questions. He truly was interested in my condition and helping me to regain good health. Sharik is interested in helping restore health to everyone. Saying thank you will never be enough. But I am forever grateful!!!!!!


When panels' tool buttons become disabled, they have a graphic box over the button. This is bad when you have custom icons that are not boxes.
Thank you for reading and for your possible future help.
It gets masked to show disabled state. You can easily change this via CSS as .x-mask class has the background rule.
Thank you, I set the opacity to 0.
Is this the only way to display the disabled state of a tool button?
Or is it possible to have an image for the disabled state?


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ON TOUR: MORGES, SWITZERLAND | Alonzo King LINES Ballet
« Echirolles, France | November 20-21 | ON TOUR
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Join Alonzo King LINES Ballet on tour in Morges, Switzerland performing Common Ground and Handel at the Théâtre de Beausobre.
With Common Ground, Alonzo King joined the famous Kronos Quartet to create an ode to the city of San Francisco. Two of the most influential cultural ambassadors of this artistic capital, King and Kronos created a visionary collaboration. The musicians explored the string quartet in a permanent conversation with the dancers. Together they invented before our eyes the vocabulary of a new classical dance… one of fluidity, technicality and grace. Experience King and Kronos Quartet's masterpiece on tour with stunning recorded music and live dance.
In 1741, Händel said of his last composition: "Whether I was in my body or outside of it when I wrote it, I do not know …". By exploring his work in Handel, Alonzo King is in turn touched by grace: a messenger of the celestial harmony of bodies, he restores the dramatic elegance of baroque expression in an evocative choreography that resonates deeply with the nobility of the music. The pure lines of the dancers miraculously reflect Händel's vision of a new balance between thematic richness and simplicity.
Photo Credit: Alonzo King LINES Ballet | Dancers: Babatunji | © Chris Hardy
The LINE UP: Jazz Funk with Alli Fritz
Summer Dance Camp at YMCA: Ages 5-8
July 22 at 9:00 AM - 4:30 PM
Dates: November 24
Théâtre de Beausobre
Avenue de Vertou 2
Morges, 1110 Switzerland + Google Map


A 5-minute walk from Pichai Courtyard, Qingdao Shinan·Qingdao Railway Station· Locals Apartment 00167310 is located in the Shinan District district of Qingdao. Free WiFi is provided. The apartment has 2 bedrooms, a TV, an equipped kitchen, a washing machine and a bathroom with a shower. St. Michael's Cathedral Church is 0.4 miles from the apartment. Qingdao Liuting International Airport is 19 miles from the property.


These are photos on Youtube of the Haradh (حرض) peace conference in Yemen taken in May, 1965 by Richard Blalock. In attendance were Shaykh 'Abd Allāh al-Aḥmar, Ustādh Nu'mān and Qadi 'Abd al-Raḥman al-Iryānī.
Here are two old postcard photographs of doors in Hodeidah.
The past of Yemen is preserved in many ways, including quite a few postcards from the early part of the 20th century, especially from Aden. Here are a few examples. If you have any you would like to see posted to this blog, please email the webshaykh at aiys.president@aiys.org.
Dr. Abd al-Karim Al-Eryani (AKI) was diminutive—I mean short, really short. From time to time, a professor in the PhD program in Yale allegedly would come into class and exclaim: "Can't believe it, but I just saw a driverless car with no one behind the wheel speeding across the campus." The car he was alluding to was in fact one being driven by AKI who could only look through and not over the wheel.
If it wasn't Dr. AKI who told me this tale, it was probably Middle East specialist Michael Hudson who did. He and AKI were PhD students at Yale at the same time, Mike in political science and AKI in biology. And this reminds me that it was Mike who facilitated my meeting Dr. AKI, and it also lets me illustrate things about the man. As the following tale suggests, and regardless of his place in government, society or family, Dr. AKI did not tower over people—and this was not a function of his physical size. He was by nature a welcoming, open and generous man.
At the urging of a political friend in Taiz, I had come to Sanaa in spring 1976 in order to meet Dr. AKI, head of the Central Planning Organization. An unemployed American academic and a refugee from Lebanon's Civil War, I only made it halfway up the stairs to Dr. AKI's office before I totally lost confidence, stopped and retreated. Luckily for me, following me down the stairs was my friend Mike Hudson who had just met with his friend, Dr. AKI. When Mike told me he was going the next day down to the Tihama with Dr. AKI for three days for a ceremony at the Wadi Zabiid Project, I proclaimed my envy. Mike said: "No problem. Show up with your bag at the hotel tomorrow morning. I will introduce you to Dr. AKI and he will invite you to go along. And that is precisely what happened.
We had a wonderful three days together, going down to and from the Tihama, in Wadi Zabid and for two nights in a modest hotel in al-Hodeidah. Over these days, I learned more about the politics and recent political history of Yemen than I had over the previous half year in the country. This proved to be the beginning of my political education—and nearly forty years of friendship. He welcomed me with open arms dozens of times. Some three decades later, not long after the Yemeni unification that he had helped engineer, Abd al-Karim invited me and several others for a week's stay on an extraordinary island, Socotra. We had a wonderful time, as did the Yemeni politician with the PhD in biology from Yale. I think Mike Hudson was with us.
Was Dr. AKI politically naïve? Yes—and no. I think he was forever a political optimist, and at times I thought he was too much so. When exasperated colleagues urged that after decades it was time to be rid of Dr. AKI, President Salih is alleged to have said "No, we need him and are going to work and ride him like a donkey until he drops over dead".
In his second tour as prime minister, Dr. AKI chose as a main task the reform of a greatly inflated, incompetent and costly civil service that had gotten worse over the decades. After months of effort, he was able to go before President Salih and announce that he had finally achieved agreement on a plan that would eliminate thousands of "shadow" positions, save lots of money and allow the leadership to focus on creating an effective government work force. In response, the president announced to Dr. AKI that he had just reinforced tribal support for the regime by creating and financing thousands of "shadow" military jobs for tribal militias. And so it went.
On the other hand, Dr. AKI often revealed a strong sense of political insight and awareness. Introduced to the Arab world in the late 1950s, I was for decades a disciple of Gamal Abdul Nasser, and coming to Yemen in 1975, a year after Ibrahim al-Hamdi seized power, I quickly became something of a disciple to the person many hailed as "the little Nasser". Early on, I noticed in Dr. AKI a lack of enthusiasm for President al-Hamdi, and at some point I questioned him on this. He answered with a story: "On one of the few times I met alone with Ibrahim he drew close to me, tapped me on my knee, and softly said this: "'Abd al-Karim, I have one great weakness—I don't trust anyone.' Quickly, Ibrahim's distrust poisoned his regime and spread to everyone. And, in the end, his colleagues in the military got him before he got them." Clearly, Dr. AKI's take on al-Hamdi was much better than mine.
Another story told to me by Dr. AKI or someone else in the Al-Eryani family relates to the above. When the rare military member of the family, the one who had previously advised President Abd al-Rahman al-Eryani on military affairs, returned to Yemen from exile, he told members of the family that the distribution of troops around Sanaa could only mean that the military was positioned to overthrow al-Hamdi. When he asked family leaders whether he should warn al-Hamdi of the danger, he was told by Dr. AKI that the president, long suspicious and distrustful of the al-Eryani family, would reject the warning, accuse the family of sowing discord, and punish the al-Eryanis.
To donate to the Memorial Fellowship Fund for Yemeni Scholars in honor of Dr. Al-Eryani, click here.


STOCKTON, Calif. - The Pacific Golf team revised its' fall schedule following Saturday's cancellation of the Paintbrush Invitational at the University of Denver. The Tigers will now compete next in Price's "Give 'Em 5" Invitational in El Paso, October 20-22.
Preparations for the Paintbrush Invitational became a scramble Saturday when the weather forecast turned bleak. With snow flurries on the horizon, the University of Denver canceled the event, leaving 12 teams looking for another tournament.
"It's unfortunate we couldn't compete this week," head coach John Cook said. "But Coach Erik Billinger and his staff at Denver did a great job of making an early decision and communicating with the field so we could change our travel plans."
UTEP expanded the field for Price's "Give 'Em 5" Invitational to accommodate a number of teams, including the Tigers. The Tigers made arrangements from the airport where they were about to depart for Denver when the cancellation occurred.
"Obviously, our thanks go out to Miners' coach Scott Lieberwirth for the opportunity to compete at their event," Cook said.
Price's "Give 'Em 5" Invitational will start Friday, October 20, at Butterfield Trail Golf Course.


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Below are 17 best pictures collection of small shed house photo in high resolution. Click the image for larger image size and more details.


text:
U.S. Pork Industry Works To Contain African Swine Fever Ravaging China's Hogs
Donald Marvin Contributor
Gene editing could produce a virus-resistant pig in the future.
Pork is the most widely consumed meat in the world, and China, as the largest consumer and producer, is the primary reason why pork has earned its status as the world's favorite protein. That's why the ongoing battle with African swine fever (ASF) in the Chinese hog herd poses some serious market implications for global agriculture.
Since China's Ministry of Agriculture and Rural Affairs confirmed the ASF outbreak in Liaoning Province in early August 2018, the United Nation's Food and Agriculture Organization (FAO) has reported that the contagion has spread across all of China's provinces, and into Vietnam and Cambodia. And last week, the virus had reportedly spread to North Korea, a country that is unlikely to make any effort toward containment.
ASF is a viral disease that is both highly contagious and almost always fatal. While the virus cannot be transmitted to humans and is not a food-safety threat, the economic consequences from a spread of this disease are potentially devastating.
Some context on the China situation illustrates what is at stake. China consumes about 56 billion pounds of pork per year, more than half of total global consumption. Likewise, the Chinese hog herd numbers more than 440 million head, which is nearly three times larger than all of Europe and almost six times larger than the U.S., the second largest pork-producing nation.
Given the impact and the spread of the disease, China's Ministry of Agriculture recently estimated that up to 80% of hog producers have no immediate plans to re-stock their herds. According to government estimates, the Chinese breeding herd of sows has been reduced somewhere in the range of 8 million head. The total U.S. sow herd is 6.4 million head.
Rabobank, the Dutch global ag financing giant, estimates that between 150 and 200 million hogs and pigs have been infected with the deadly disease and will be lost. Compare that to the total U.S. harvest of barrows and gilts for pork production in 2018 of 124 million head. In other words, China will not be able to import enough pork to offset its production losses, and the ravages of ASF will ripple through the global market.
Consider U.S. soybean exports to China, currently hampered by retaliatory tariffs resulting from the U.S.-China trade dispute. Shipments to China won't fully recover even once the tariffs are lifted owing to the dramatic reduction in China's swine herd. ASF in China will affect the bottom-line of U.S. soybean growers.
However, the bigger picture issue is how to contain and treat this, and other, animal health threats. Currently, there is no treatment or vaccine for ASF. Thus, the emphasis has been on prevention and containment, which is largely a matter of implementing strict and complex sanitary measures and remaining vigilant. For example, earlier this year, the U.S. National Pork Producers' Council canceled its annual World Pork Expo in Des Moines, Iowa, as an exercise in "extreme caution" over attendees from ASF-positive regions. The Expo, which has been held annually since 1987, is the largest pork industry trade show in the world, drawing more than 20,000 visitors.
But more sinister threats evolve from the economic disruption caused by ASF. Just this past March, the USDA and the U.S. Customs and Border Protection agency intercepted more than 50 shipping containers loaded with approximately one million pounds of pork from China. The meat had been mislabeled and hidden among other products entering the Port of New York/Newark. Indeed, pork and pork products are a known vehicle for transmitting this virus and could introduce it to the U.S.
Dan Kovich, DVM and the director of science and technology for the National Pork Producers Council, said his organization is coordinating containment efforts with its counterparts in Canada and Mexico to prevent the spread of AFS to North America. The U.S. containment effort involves not only pork producers but all the many key animal health entities such as the American Association of Swine Veterinarians, Swine Health Information Center, National Swine Disease Council, and state and federal animal health agencies.
"Of course, we also have to think about how we would respond if, heaven forbid, it were to come here," said Kovich. "We are working very closely with USDA and Customs and Border Protection to make sure that we identify and address all of our vulnerabilities."
Agtech companies have an important part to play in addressing and solving zoonotic diseases. And the work is underway. In light of the ASF situation, Boehringer Ingelheim and GNA Biosolutions recently announced a new research partnership to develop a quick-test diagnostic tool for ASF. Obviously, early detection of ASF is fundamental to containment.
Genomic mapping and gene-editing/CRISPR technology hold great potential for preventing viral diseases such as ASF. Breaking the cycle of transmission of such diseases could also reduce the use of antibiotics and potentially pay dividends in addressing antimicrobial resistance.
"We as an industry right now are looking at the potential of a gene-edited pig that's resistant to the ASF virus," said Kovich. "The exciting thing about gene editing is that it allows us to make changes within the animal's own genome that, given its efficacy, will give us a whole new toolbox to deal with these viral diseases."
"That is sometime in the future, but we are actively working to try and find a workable regulatory pathway so that when these tools are available, we have a way to be able to utilize them in our herds," he said.
Donald Marvin
I am president and CEO of Concentric, a developer and producer of proprietary biological and plant nutrient inputs for specialty and broadacre crops. Concentric was name...


text:
The Meaning of the Great Fast (Part II)
February 06, 2017 / Amber
Virginmartyr Martha in Egypt
by His Eminence Metropolitan Kallistos Ware
The True Nature of Fasting
Lenten abstinence gives us the saving self-dissatisfaction of the Publican (St. Luke 18:10-13). Such is the function of the hunger and the tiredness: to make us 'poor in spirit', aware of our helplessness and of our dependence on God's aid.
Yet it would be misleading to speak only of this element of weariness and hunger. Abstinence leads, not merely to this, but also to a sense of lightness, wakefulness, freedom and joy. Even if the fast proves debilitating at first, afterwards we find that it enables us to sleep less, to think more clearly, and to work more decisively. As many doctors acknowledge, periodical fasts contribute to bodily hygiene. While involving genuine self-denial, fasting does not seek to do violence to our body but rather to restore it to health and equilibrium. Most of us in the Western world habitually eat more than we need. Fasting liberates our body from the burden of excessive weight and makes it a willing partner in the task of prayer, alert and responsive to the voice of the Spirit.
It will be noted that in common Orthodox usage the words 'fasting' and 'abstinence' are employed interchangeably. In the Orthodox Church a clear-cut distinction is not made between the two words. During Lent there is frequently a limitation on the number of meals eaten each day, but when a meal is permitted there is no restriction on the amount of food allowed. The Holy Fathers simply state, as a guiding principle, that we should never eat to satiety but always rise from the table feeling that we could have taken more and that we are now ready for prayer.
It is important not to overlook the physical requirements of fasting, it is even more important not to overlook its inward significance. True fating is not a mere matter of diet. It is moral as well as physical. True fasting is to be converted in heart and will; it is to return to God, to come home life the Prodigal son to our Father's house. In the words of Saint John Chrysostom, it means "abstinence not only from food but from sins." "The fast," he insists, "should be kept not by the mouth alone but also by the eye, the ear, the feet, the hands and all the members of the body": the eye must abstain from impure sights, the ear of malicious gossip, the hands from acts of injustice. It is useless to fast from food, protests Saint Basil, and yet to indulge in cruel criticism and slander: "You do not eat mean, but you devour your brother." The same point is made in the Triodion, especially during the first week of Holy Lent:
As we fast from food, let us abstain also from every passion...
Let us observe a fast acceptable and pleasing to the Lord.
True fasting is to put away all evil,
To control the tongue, to forbear from anger,
To abstain from lust, slander, falsehood and perjury.
If we renounce these things, then is our fasting true and acceptable to God.
Let us keep the Fast not only by refraining from food,
But by becoming strangers to all the bodily passions. (Vespers for Sunday evening Sunday of Forgiveness)
The inner significance of fasting is best summed up in the triad: prayer, fasting, almsgiving (charity). Divorced from prayer and from the reception of the Holy Mysteries (Sacrament), unaccompanied by acts of compassion, our fasting becomes pharisaical or even demonic. It leads, not to contrition and joyfulness, but to pride, inward tension and irritability. The link between prayer and fasting is rightly indicated by Father Alexander Elchaninov. A critic of fasting says to him: "Our work suffers and we become irritable...I have never seen servants [in pre-revolutionary Russia] so bad tempered as during the last days of Holy Week. Clearly, fasting has a very bad effect on the nerves.' To this Father Alexander replies: 'You are quite right...If it is not accompanied by prayer and an increased spiritual life, it merely leads to a heightened state of irritability. It is natural that servants who took their fasting seriously and who were forced to work hard during Lent, while not being allowed to go to church, were angry and irritable.'
Fasting, then, is valueless or even harmful when not combined with prayer. In the Gospel the devil is cast out, not by fasting alone, but by "prayer and fasting" (St. Matthew 17:21; St. Mark 9:29); and of the early Christians it is said, not simply that they fasted, but that they "fasted and prayed" (Acts 13:3; compare 14:23). In both the Old and the New Testament fasting is seen, not as an end in itself, but as an aid to more intense and living prayer, as a preparation for decisive action or for direct encounter with God. Thus our Lord's forty-day fast in the wilderness was the immediate preparation for his public ministry (St. Matthew 4:1-11). When Moses fasted on Mount Sinai (Exodus 34:28) and Elijah on Mount Horeb (3 [1] Kgs. 19:8-12), the fast was in both cases linked with a theophany. The same connection between fasting and the vision of God's is evident in the case of Saint Peter (Acts 10:9-17). He "went up on the housetop to pray about the sixth hour, and he became very hungry and wanted to eat"; and it was in this state that he fell into a trance and heard the divine voice. Such is always the purpose of ascetic fasting--to enable us, as the Triodion puts it, to "draw near to the mountain of prayer."
Prayer and fasting should in their turn be accompanied by almsgiving--by love for others expressed in practical form, by works of compassions and forgiveness. Eight days before the opening of the Lenten fast, on the Sunday of the Last Judgment, the appointed Gospel is the Parable of the Sheep and the Goats (St. Matthew 25:31-46), reminding us that the criterion in the coming Judgment (the Final Judgment), will not be the strictness of our fasting but the amount of help that we have given to those in need.
ON FEBRUARY 12th: THE SUNDAY OF THE PRODIGAL SON (St. Luke 15:11-32)
The parable of the Prodigal son forms an exact icon of repentance in its different stages. Sin is exile, enslavement to strangers, hunger. Repentance is the return from exile to our true home; it is to receive back inheritance and freedom in the Father's house. But repentance implies action: "I will rise up and go..." (verse 18). To repent is not just to feel dissatisfied, but to make a decision and to act upon it.
On this and the next two Sundays, after the solemn and joyful words of the Polyeleos at Orthros (Matins), we add the sorrowful verses of Psalm 136, "By the waters of Babylon we sat down and wept..." This Psalm of exile, sung by the children of Israel in their Babylonian captivity, has a special appropriateness on the Sunday of the Prodigal, when we call to mind our present exile in sin and make the resolve to return home. (Source: The Lenten Triodion)
MY BLESSING TO ALL OF YOU
The Grace of Our Lord Jesus Christ, and the love of God and Father, and the communion of the Holy Spirit be with you all. Amen.
"Glory Be to GOD For All Things!"--Saint John Chrysostom
With sincere agape in His Holy Diakonia,
February 06, 2017 / Amber/
The Preaching of the Apostles (Part ...


text:
Q: Contextual type 'AnyObject' cannot be used with dictionary literal I have some problems with my Swift project. I am making an app where you can be notified about when you need to take your medicine.
Here is the file where the error code is generated:
import Foundation
import UIKit

class TodoList {
class var sharedInstance : TodoList {
    struct Static {
        static let instance : TodoList = TodoList()
    }
    return Static.instance
}

private let ITEMS_KEY = "todoItems"

func allItems() -> [TodoItem] {
    let todoDictionary = NSUserDefaults.standardUserDefaults().dictionaryForKey(ITEMS_KEY) ?? [:]
    let items = Array(todoDictionary.values)
    return items.map({TodoItem(deadline: $0["deadline"] as! NSDate, title: $0["title"] as! String, gentag: $0 ["gentag"] as! RepeatInterval, UUID: $0["UUID"] as! String)}).sort({(left: TodoItem, right:TodoItem) -> Bool in
        (left.deadline.compare(right.deadline) == .OrderedAscending)
    })
}

func addItem(item: TodoItem) {
    // persist a representation of this todo item in NSUserDefaults
    var todoDictionary = NSUserDefaults.standardUserDefaults().dictionaryForKey(ITEMS_KEY) ?? Dictionary() // if todoItems hasn't been set in user defaults, initialize todoDictionary to an empty dictionary using nil-coalescing operator (??)
    todoDictionary[item.UUID] = ["deadline": item.deadline, "title": item.title, "gentag": item.gentag.toCalendarUnit(), "UUID": item.UUID] // store NSData representation of todo item in dictionary with UUID as key
    NSUserDefaults.standardUserDefaults().setObject(todoDictionary, forKey: ITEMS_KEY) // save/overwrite todo item list

    // create a corresponding local notification
    let notification = UILocalNotification()
    notification.alertBody = "Hej \"\(item.title)\"Test, husk at tage din medicin: \"\(item.title)\"" // text that will be displayed in the notification
    notification.alertAction = "Skub for at tage medicin" // text that is displayed after "slide to..." on the lock screen - defaults to "slide to view"
    notification.fireDate = item.deadline // todo item due date (when notification will be fired)
    notification.soundName = UILocalNotificationDefaultSoundName // play default sound
    notification.userInfo = ["title": item.title, "UUID": item.UUID] // assign a unique identifier to the notification so that we can retrieve it later
    notification.repeatInterval = item.gentag.toCalendarUnit()

    UIApplication.sharedApplication().scheduleLocalNotification(notification)
}

func removeItem(item: TodoItem) {
    for notification in UIApplication.sharedApplication().scheduledLocalNotifications as [UILocalNotification]! { // loop through notifications...
        if (notification.userInfo!["UUID"] as! String == item.UUID) { // ...and cancel the notification that corresponds to this TodoItem instance (matched by UUID)
            UIApplication.sharedApplication().cancelLocalNotification(notification) // there should be a maximum of one match on UUID
            break
        }
    }

    if var todoItems = NSUserDefaults.standardUserDefaults().dictionaryForKey(ITEMS_KEY) {
        todoItems.removeValueForKey(item.UUID)
        NSUserDefaults.standardUserDefaults().setObject(todoItems, forKey: ITEMS_KEY) // save/overwrite todo item list
    }
}

Here is the line which generates the error:
 todoDictionary[item.UUID] = ["deadline": item.deadline, "title": item.title, "gentag": item.gentag.toCalendarUnit(), "UUID": item.UUID] // store NSData representation of todo item in dictionary with UUID as key

Here is the error text:

Contextual type 'AnyObject' cannot be used with dictionary literal

Here is my ToDoItem class
import Foundation

struct TodoItem {
    var title: String
    var deadline: NSDate
    var gentag: RepeatInterval
    var UUID: String

   init(deadline: NSDate, title: String, gentag: RepeatInterval, UUID: String) {
        self.deadline = deadline
        self.title = title
        self.gentag = gentag
        self.UUID = UUID
    }

    var isOverdue: Bool {
        return (NSDate().compare(self.deadline) == NSComparisonResult.OrderedDescending) // deadline is earlier than current date
    }
}

A: I am not able to reproduce your trouble ....
import Foundation

struct S {
    var i = 1
    var b = true
    var c = 1.0
    var id = "XYZ-ID"
}

var d = NSUserDefaults.standardUserDefaults().dictionaryForKey("dummy_key") ?? [:]
let s = S()
d[s.id] = ["i":s.i, "b":s.b, "c":s.c]

print(d)
/*
 ["XYZ-ID": {
 b = 1;
 c = 1;
 i = 1;
 }]
*/

The error you receive means, that swift can't create AnyObject on the right side of the assignment. Check it separately, most likely it is  because RepeatInterval doesn't have bridged Foundation counterpart.

redpajama_set_name: RedPajamaStackExchange


Babies Can't Wait — Talk Time for Kids, Inc.
Talk Time for Kids, Inc.
Babies Can't Wait (BCW) is Georgia's early intervention program for infants and toddles with developmental delays and disabilities and their families. We are contracted with Fulton and Dekalb Counties.


text:
import type { CSSMotionProps, MotionEndEventHandler, MotionEventHandler } from 'rc-motion';
import type { MotionEvent } from 'rc-motion/lib/interface';
import { tuple } from './type';

// ================== Collapse Motion ==================
const getCollapsedHeight: MotionEventHandler = () => ({ height: 0, opacity: 0 });
const getRealHeight: MotionEventHandler = node => {
  const { scrollHeight } = node;
  return { height: scrollHeight, opacity: 1 };
};
const getCurrentHeight: MotionEventHandler = node => ({ height: node ? node.offsetHeight : 0 });
const skipOpacityTransition: MotionEndEventHandler = (_, event: MotionEvent) =>
  event?.deadline === true || (event as TransitionEvent).propertyName === 'height';

const collapseMotion: CSSMotionProps = {
  motionName: 'ant-motion-collapse',
  onAppearStart: getCollapsedHeight,
  onEnterStart: getCollapsedHeight,
  onAppearActive: getRealHeight,
  onEnterActive: getRealHeight,
  onLeaveStart: getCurrentHeight,
  onLeaveActive: getCollapsedHeight,
  onAppearEnd: skipOpacityTransition,
  onEnterEnd: skipOpacityTransition,
  onLeaveEnd: skipOpacityTransition,
  motionDeadline: 500,
};

const SelectPlacements = tuple('bottomLeft', 'bottomRight', 'topLeft', 'topRight');
export type SelectCommonPlacement = typeof SelectPlacements[number];

const getTransitionDirection = (placement: SelectCommonPlacement | undefined) => {
  if (placement !== undefined && (placement === 'topLeft' || placement === 'topRight')) {
    return `slide-down`;
  }
  return `slide-up`;
};

const getTransitionName = (rootPrefixCls: string, motion: string, transitionName?: string) => {
  if (transitionName !== undefined) {
    return transitionName;
  }
  return `${rootPrefixCls}-${motion}`;
};
export { getTransitionName, getTransitionDirection };
export default collapseMotion;

redpajama_set_name: RedPajamaGithub


text:
Q: How to put database information as headers in table I want some information that is stored in my database to be an header in a table.
Basically its got a list of competitors down the side with theirs scores running in rows. Each competitor has their own row. At the top of the table is the name of the event they took part in. I cant manage to make the event name come from the database so got to edit the page each time I add a set of scores.
I have attempted as you will see in the code below;
<?php
require("db_connect.php");
$result = mysql_query("SELECT *, (ct1 + ct2 + ct3 + ct4 + ct5 + ct6) AS results FROM resultsopen WHERE ct='1'");

if(mysql_num_rows($result) == 0) { echo 'No competitors found'; } else {

echo "

        Competitor
        Member No
        " . $row['cta'] . "
        E2
        E3
        E4
        E5
        E6
        E7
        Overall

";

$x=1;
while($row = mysql_fetch_array($result))
    {
    if($x%2): $rowbgcolor = "#FFFFFF"; else: $rowbgcolor = "#EEEEEE"; endif;
    echo "
";
    echo "" . $row['competitor'] . "	";
    echo "" . $row['memberno'] . "	";
    echo "" . $row['ct1'] . "	";

The line in question is " . $row['cta'] . "
The other lines are just text which I manually change each time.
I also know that mysql should be changed to mysqli but I am not confident in the change just yet.


When the math says sell, it's time to take some profits ... but sometimes you can make an exception or two.
I hate to complain about a bull market that just turned six years old and shows no signs of slowing down. But I've begun to wonder whether we're enjoying too much of a good thing. Key indexes are regularly hitting new highs, and one, the Nasdaq Composite, recently crossed 5000 for the first time since 2000. All this exuberance has spurred me to take a closer look at my portfolio to see if any of my holdings are grossly overvalued.
I have a simple check: I want a stock's price-earnings ratio to be near or, even better, below the sum of a company's earnings-growth rate and its dividend yield. In other words, if profits are growing 10% a year and a stock yields 2%, I'm happy to pay 12 times earnings. But barring some extenuating circumstance, a P/E well over 12 would signal that the stock has gotten too pricey for my taste. After reviewing all 20 stocks in my Practical Investor portfolio, I found that most remain reasonably priced, and a few are actually cheap. But there are some exceptions.
Dover Corp. (DOV, $71) looks dear, too. It yields 2.3%, and analysts see the conglomerate's profits rising 5% this year and 8% the next. Based on my formula, I should be antsy with a P/E much greater than 10, and Dover trades at 19 times 2015 estimates.
But I see a couple of mitigating factors. First, Dover is a dividend superstar; it has hiked its payout in each of the past 59 years. Moreover, Dover, like Chevron, has been hurt by low oil prices because about one-fourth of its earnings come from energy services, says Stifel Nicolaus analyst Nathan Jones. Dover has been wisely cutting costs to mute the effect of the oil crash and is in the process of selling two divisions in an effort to improve profitability. For now, I'm hanging on to this well-managed company.
Johnson & Johnson (JNJ, $100) is another story. The iconic health care giant—it makes drugs, devices and consumer products, such as baby oil—is one of only three industrial companies with a triple-A bond rating. J&J is also a dividend aristocrat, having raised its disbursement for 52 consecutive years. The stock yields a decent 2.8%.
Drug problems. But growth has turned tepid. J&J's device business lost ground in 2014, although strong pharmaceutical sales propped up earnings. But the prognosis for the drug segment isn't rosy. European patents for the blockbuster anti-inflammatory drug Remicade, which J&J co-markets with Merck, expired in February, and significantly cheaper "bio-similar" drugs have begun to inundate European markets. Trefis, a research firm, says that Remicade accounts for 25% of J&J's drug sales. Other J&J drugs are also under pressure.
Analysts see J&J's earnings expanding by 4% this year and 5% in 2016, but I worry that even those modest figures may be too optimistic. At any rate, adding the higher figure to a yield of nearly 3% tells me that J&J's shares are worth less than 10 times earnings. But the stock's P/E is 16.
That's too pricey for me. I sold 168 shares of J&J at $102.88 (holding on to one share to make it easy to track the stupidity or wisdom of the move). Until I find a stock I think is cheap and attractive, I'll hold on to the proceeds of $17,284.


text:
Q: Straight selection sort vs. exchange selection sort What is the difference between straight selection sort vs. exchange selection sort? I got into a little debate today - my professor uses these two terminologies in his lecture notes. The selection sort that Wikipedia and any textbook or website will give you is what he is calling "exchange selection sort".
I've never heard the term "exchange selection sort" used before (only "selection sort"), and cannot find any relevant resources on the former terminology online. Also, "exchange sort" redirects to bubble sort on Wikipedia.
I've also never heard the term "straight selection sort" used before, and cannot find any relevant resources online. His notes state that it's a version of selection sort which uses a secondary array rather than an in-place sort, populating it one-by-one from the smallest to largest element. When I brought up the issue he claimed it was older and that just because it doesn't come up on Google doesn't mean it's incorrect. However, I've found far more obscure things on Google, and something like selection sort is going to have a massive amount of resources on the web.
So, do these algorithms go by other names? Does he simply have the names wrong? Who is right?

A: I hadn't heard those exact terms before but they make sense to me. I don't think the terminology is really that important as long as you understand what they're doing.
If you're creating a sorted copy of a list, you can create each item in the new list one-by-one from the minimum of the old list; 'straight' seems as reasonable a description as any for this.
OTOH if you're sorting a list in-place then each time you move a new item to the head of the list, you have to move the item that was previously there backwards to make room. In an array list the cheapest way to do that is just to left the new minimum item and the old item swap places: an exchange. (In a linked list it would be quicker to let the whole tail of the list slide back one place.)
Textbooks tend to concentrate on in-place sorting.

A: Both the algorithms have the same technique. However, the only difference between the two is that in the selection sort, only the index is updated every time the comparison is made and the swapping happens at the end of an iteration. On the other hand, in exchange sort, the swapping happens as soon as the element on the right side is smaller than the one which is present at the current position.
For reference, you can see these 2-minute videos:
Insertion sort: https://www.youtube.com/watch?v=JU767SDMDvA
Exchange sort: https://www.youtube.com/watch?v=v0ipy1h-TPM


text:
Brocas Helm > Black Death > Reviews > brocashelm
Amazon.com more... >>
Brocas Helm
View all reviews for Brocas Helm - Black Death
How Metal Can You Get? - 85%
brocashelm, December 31st, 2008
A cult band to be sure, Brocas Helm hailed from San Francisco, and did things in their own cryptically inclined manner. This manner meant composing battle ready battleaxe anthems in a style very much their own. Shades of Manilla Road and Cirith Ungol appear, but that's more due the similarity Brocas Helm shares with other US bands doggedly insistent on forging their own style. This releases followed up the band's hopelessly rare debut Into Battle, and was recorded on an 8 track machine, giving the prospective listener the heads up that this isn't going to sound like a big budget deal. But that's irrelevant, because what the Helm craft here is nothing less than some of the most unique US metal ever forged. Just dig the medieval melodies and proud structures that highlight the title cut and "Prepare For Battle," the creepy vibe of "Hell's Whip" and the Motorhead rythym of "Satan's Prophets." The regal "Fly High" is a power metal anthem brimming with excellence, while "The Chemist" is a queer and dark medieval jig of great atmosphere and feel. All of this is presented in a tough but melodic style led by guitarist and singer Bobbie Wright and armed with the voltage of a band loaded with enthusiasm and skill. A classic disc, this one was lost in the winds of time for ages but is now re-issued and ready for action. By the way, the band called their low-budget studio facility "The Caverns Of Thunder," and "recorded under a haunted moon." How metal can you get, man?


With a surplus of $4.5 billion this year, $500 million higher than forcast, the St Vincent de Paul Society NSW is disappointed very little was allocated to where the need is greatest – breaking the affordable housing gridlock facing the state.
"Yes, there's more for rail, roads, schools and hospitals, which is welcome news, but the homeless and voiceless seem to have been forgotten yet again. The Government will spend just 1.6 per cent of its expenditure on housing and community amenities in 2017-18," says CEO Jack de Groot.
"Tonight people will be sleeping rough, in their car, at friends or at one of our crisis accommodation facilities, until they manage to find a permanent place to live in a state that has become unaffordable.
"Yet as this Budget proves, our state is incredibly rich. We maintain a triple-A credit rating. However, the pursuit of credit ratings cannot be priviledged over the right to home for the estimated 190,000 lower income private renter households in NSW who are in housing stress.
"On the first day of her premiership Gladys Berejiklian announced her commitment to combatting the housing crisis, saying it was the biggest issue facing us as a state. Today, other than relief for some first time buyers, there is nothing on the ledger for those people who are paying up to 70 per cent of their income on rent and who face homelessness.
"The Government's own estimates tell us we need an additional 25,000 social housing properties over 10 years to simply maintain the level of social housing – investment this year and each year is essential.
"With energy prices soaring by 20 per cent we are going to see many more people facing housing stress, where a tenant spends over 30 per cent of their income on accommodation.
The announcement of an additional $20.4 million over four years to support Homelessness Strategy initiatives, providing an additional 120 transitional accommodation units and support packages for rough sleepers is welcome. The next step for the surplus is social and affordable housing.
"This Budget is not the blueprint required for a long-term, financially sound social and affordable housing sector able to deliver safe, accessible and high-quality housing for the poorest.


text:
Q: Use mysql user variables in Zend Framework 2 I want to run a mysql query including variables. A simple version of this looks like that:
$sql = "UPDATE mytable,
(SELECT @counter := IFNULL(@counter,0) + 1 as new_value,
        mycolumn
 FROM othertable
 ORDER BY mycolumn) i
SET mytable.counter_column = i.new_value
WHERE i.mycolumn = mytable.mycolumn";

$this
  ->getSlaveSql()
  ->getAdapter()
  ->getDriver()->getConnection()->execute($sql);

But the result value is always 1. If I run the query directly, I have a correct line of numbers. I think, the variables will be unset bei Zend, so that @counter is 0 on every row.

A: I used a stored procedure for this now.


In the tradition of exhibitions past given to wordplay, Lopez Museum presents Grounded broadly suggestive as it is of a stretch of phrases: failure to launch, electronic misfires, immobilized states, rootedness. Fittingly enough, this latest exhibition poses Lopez Museum as it emerges from its fairly recent coming of age (having gone public in 1960) and as it prepares for a big move to Rockwell Makati making this as good a time as any to take stock and push itself through time and space.
As Lopez Museum is still associated with its trove of Lunas, Hidalgos and not insignificant assembly of Filipino modernists' work, Grounded asks: how is that art can be seen as a means to take flight while remaining anchored at the same time? How can a sacralized space like a museum turn into a site that hosts such contradictions? How can this dis-ease, of straining forward while staying entrenched make for a productive place, of navigated distress?
The exhibition frames these queries through pieces that have long been accessioned into Lopez Museum archives such as Amorsolos, Lunas, Hidalgos, along with Manuel Blanco's Floras de Filipinas, and period images from the Ambassador Jose Teodoro bequest, among others.
These questions are brought to the here and now too through contemporary works commissioned and/or invited unto the exhibition: Alma Quinto's Jutay research project drawing upon insight from Pasig River warriors among other parties with a stake in our privations in education; Eric Zamucos' dually poetic and physically engaging Not of Water installative suspension; Goldie Poblador's tauntingly fragile glass piece sculpture, Ang Simula ng Pagsibol; Barbara Hlali's achingly stark video Revolution Contra Revolution; Ahmad Al Shaer's game pun on Charles Darwin's setting off gene-spurred politics; Toym Imao's alliterative constructions riffing off news and classical art references; Khaled Hafez's object spin on undelivered revolutionary promise; and Josephine Turalba's clunky floorpieces, Scandals.
The exhibit will be punctuated by works of National Artists Jose Joya and Federico Alcuaz, Juan Arellano, Roberto Chabet, Brenda Fajardo, Juvenal Sanso, Nena Saguil, and Pacita Abad, Grounded is a visual simulation of layered conversations emanating from a cacophony of sensibilities and diverse bases.
Grounded is curated by Back to Square Juan artistic director Claro Ramirez. It will run until August 3, 2013. Lopez Museum and Library is at the G/F Benpres Bldg., Meralco cor. Exchange Rd., Ortigas Center, Pasig City. Museum hours are 8-5pm Mondays through Saturdays except Sundays and holidays.
Previous Previous post: WEBCOMICS: Our Third Installment of "The Man in the Frame"
Next Next post: Art Handling Workshop: The Repeat! at Lopez Museum on 26 September, Thursday, 9am to 4pm.


text:
Cindy weakens into tropical depression after Louisiana landfall
Posted: Jun 22, 2017 10:52 PM EST
Photo courtesy NWS New Orleans/Twitter
By Nicole Chavez and Ralph Ellis
(CNN) -- Cindy weakened to a tropical depression Thursday but still brought heavy rain, powerful winds and the threat of floods to the already soaked US Gulf Coast.
Cindy was a tropical storm when it made landfall before dawn just south of Lake Charles, Louisiana, the National Hurricane Center said. At 4 p.m. CT, it was moving at 10 mph with winds of about 25 mph and was about 45 miles south of Shreveport, the National Weather Service said.
Heavy downpours were expected in East Texas, Alabama and the Florida Panhandle. More than 6 million people remain under tornado watches, an area covering New Orleans and points north into central Louisiana, Mississippi and Alabama.
So far, people are coping, Louisiana Gov. John Bel Edwards said at a news conference.
"It's not as bad as we had feared, but it's certainly not over," he said.
In Alabama, an EF2 tornado damaged buildings in Fairfield, a town outside Birmingham, CNN affiliate WVTM-TV reported. Four people were taken to the hospital with what appeared to be minor injuries, the station said.
As the storm moves north, the Gulf Coast will experience potentially dangerous flooding, CNN meteorologist Michael Guy said.
Cindy is expected to produce 3 to 6 inches of rain, with as much as 15 inches in some places, through Friday morning, the hurricane center said.
"The storm is expected to move up into Louisiana ... where it will be absorbed by an approaching cold front moving in from the Plains," Guy said.
Over the coming days, the cold front will push the remnants of the storm east and will help dump more rain over the Tennessee and Mississippi valleys.
Boy killed along Alabama coast
The National Weather Service said all the warnings for coastal areas were lifted Thursday morning, but the storm has put millions of residents under high alert of "life-threatening flash flooding" since Tuesday and already has claimed at least one life.
A 10-year-old boy from Missouri died Wednesday after a log struck him outside a beachfront condo in Fort Morgan, Alabama, the Baldwin County Sheriff's Office said.
"The boy's father was outside but several feet away attending other children and noticed a huge wave was coming ashore heading toward the log and his son," Capt. S.K. Arthur said in a statement. "The wave hit the log knocking the log into and over his son."
In coastal Hancock County, Mississippi, more than 300 streets were flooded, CNN affiliate WVUE-TV in New Orleans reported, citing emergency management officials. One resident said he'd been riding his boat through the streets.
"This is definitely the worst I've seen it so far. I had probably about (2 feet) of water," Jerry Rodriquez told WVUE. "If you live on the water, though, that's what's going to happen. You're gonna flood."
Parts of southern Alabama, southern Mississippi, southeastern Louisiana and western portions of the Florida Panhandle already have seen streets covered in up to 3 feet of water.
To reduce the chances of flash flooding, the Tennessee Valley Authority lowered levels in nine lakes, the agency said. The lakes are Fort Loudoun, Watts Bar, Chickamauga, Nickajack, Guntersville, Wheeler, Wilson, Pickwick and Kentucky.
In Texas, the Coast Guard reported rescuing a shrimp trawler with a crew of four that was taking on water about 80 miles outside Galveston. A helicopter crew lowered a pump to the ship, which the trawler crew used to keep the boat from sinking, the Coast Guard said. The ship made it safely to port Wednesday morning.
Cindy is the second tropical storm to form during the Atlantic hurricane season, which began June 1. It's the third storm of the season, which got an early start with Tropical Storm Arlene in April.
'Slow-motion disaster'
State offices in five regions of Louisiana remained closed Thursday. Parts of the state saw severe flooding Wednesday when water rose to 3 feet high in some neighborhoods, covering some mailboxes, CNN affiliate WDSU-TV in New Orleans reported.
Alabama Gov. Kay Ivey declared a state of emergency to "guarantee state resources are on standby and are ready to assist impacted communities if necessary."
"There's been a lot of rain in the area over the last three to four weeks, so the ground is pretty saturated," said Glen Brannan of Alabama's Mobile County Emergency Management Agency.
In Mississippi, Biloxi declared a state of emergency because of the flood risk. Residents in nearby counties were offered sandbags.
"It's kind of like a slow-motion disaster for us now," said Greg Flynn with the Mississippi Emergency Management Agency. "It's not wind, it's rain we're concerned about."


text:
Evictions per Filing in Illinois
Racially Disparate Patterns in Eviction Filing Outcomes
Emma Boczek, Teddy Knox
Recent research has highlighted the long-term consequences to tenants of receiving an eviction filing — even a filing that does not lead to an eviction. We examine census block group-level data to (a) determine which populations in Illinois are most affected by eviction filings that do not result in evictions, and (b) study the relationship between a census block group's racial makeup and that its evictions per filing (EPF) rate — a measure of the likelihood that a given filing will result in a legal eviction. We estimate that while African Americans in Illinois from 2000 to 2016 are overall more likely to experience eviction filings and eviction judgments, they also experience the lowest EPF rate of any racial group, suggesting that they are the population most likely to have an unjustly marred eviction record. Specifically, we find that controlling for income and other factors, a 10 point increase in a census block group's percentage of African-American residents is associated with a 4.4 percent decrease in that block group's EPF rate.


¡¡¡: Vaadin and Grails, part II., "What is in the package?"
Vaadin and Grails, part II., "What is in the package?"
Let's have a look at what makes mixture of Grails and Vaadin so great tool that one should use it.
We don't need these two features of Grails - "View layer in Groovy Server Pages" and "Controller layer built on Spring MVC" when using Vaadin. Both of these features are replaced by Vaadin components and listener pattern.
Let's have a look at how the remaining features are used together with Vaadin and how to benefit from that.
run application or tests in different environments simply just by typing dev run-app or test run-app or test test-app. So we can use different databases, test data or whatever we want to in certain stages of development process.
... and many others. Here is more info about command line.
Well, we just change a code, save the files, refresh a page and that is it. No server restarts needed. We can see the changes immediately.
Also, tomcat is provided as a grails plugin. So when we want to upgrade a new version of tomcat, we just upgrade the plugin and the compatibility with grails comes really easily.
There is i18n() method available in all Vaadin classes which makes localization pretty easy. We just type i18n("app.title") in your Vaadin code.
Then you should create a record in i18n properties files.
And we are done. Just start the application by typing dev run-app into the command line or refresh the page in case your application is already running.
If the message doesn't exist the key in square brackets is returned (e.g. [app.title]). It is pretty useful when you don't want to make localizations immediately when producing a code.
I have mentioned how to setup working Grails & Vaadin application with access to database in this post. We can use all the GORM features without limitations.
What is this service layer about? Grails services should contain logic of the application, which means that the logic should not be placed in Vaadin code (e.g. listeners). We also get transactional behavior inside our services. Grails services are providing quite many features, please study that from official tutorial.
It is as easy as to create a persistent domain class. Let's just create a service for a user (called helloworld.UserService).
So, everything is ready and we can get and use the service in Vaadin code. Let's rename all the users to Joshua.
There is a special method getBean() provided by Grails Vaadin plugin. This method is accessible in all the Vaadin classes (assuming they are located in grails-app/vaadin).
getBean() method gets a dependency from the Spring ApplicationContext. Obtaining the references is extremely fast and serialization-safe because the references are cached and Spring takes care abou that.
Well, how to use it in practice? We have to call getBean() always when we want to get a service. This approach is going to avoid strong references to usually stateless service implementations.
Ultimate application to validate, clean and format JSON, XML, SQL, HTML.
Thanks for creating the great plugin and writing the great post.
please go to: http://grails.org/plugin/vaadin and read chapter Spring Dependencies. Most interesting part is called "Reason 2". You will learn how and mainly why service dependencies work via getBean method.
Did you come across Spring Stuff add-on at https://vaadin.com/directory#addon/spring-stuff ?
I not sure whether it solved the issues you mentioned in "Reason 2" though.
@Lim, thanks for recommendation, I will check that.
Thanks Ondrej (Diky Ondreji) for great tutorial. I have a Grails application that I would like to convert to Vaadin/Grails application with your great Grails Vaadin plugin.
The application uses Spring Security plugin http://grails.org/plugin/spring-security-core. Do you have any advise/recommendation how to integrate Spring Security and Vaadin authentication https://vaadin.com/wiki/-/wiki/Main/Authenticating+Vaadin-based+applications.
And if I can be bold enough ;-) and ask for tutorial, Part III with authentication example ;-).
Diky moc za vyborny plugin!
Lubos, I can make tutorial how I authenticate grails/vaadin applications. I added that to my todo list.


text:
Categorized | Business/Economy/Banking, CARICOM, Local, News, OECS, Regional
Granger calls for less bureaucracy implementing CARICOM decisions
MONTEGO BAY, Jamaica, Jul. 6, CMC – President David Granger says he is disatified with the failure of member states of the Caribbean Community (CARICOM), to implement decisions which ultimately impact the region's dependence on extra-regional sources for food and other resources while preventing the exports of others from the region.
Speaking on the sidelines of the 39th Meeting of the Conference of Heads of Government of CARICOM here on Friday, Granger said – "I am very disturbed that after such a long time the Caribbean is not producing much more of the food it consumes on a daily basis. Honey is one of them, yes, but there are other products. Another country might be trying to export water and we find that the water is blocked, another might be trying to export stock feed. There is no fault in the CARICOM structure there is no fault in the rules I think there is a fault in the implementation."
In addition, Granger said CARICOM, as a regional body, and the 19-year-old Caribbean Single Market and Economy (CSME) are good for the region, but there needs to be less bureaucracy and more willingness to implement decisions taken.
"The point I'm trying to make is that the decisions that we took are correct. The rules and the procedures we have established over the last 45 years are correct, particularly over the last 19 years or so that CSME has come in. It's a question of bureaucratic will to implement those decisions. I don't believe anything is wrong with the decisions," he said.
The 39th Meeting of the Conference of Heads of Government of CARICOM is scheduled to end on Friday.
Amazon in deal with German watchdog to overhaul marketplace terms https://t.co/4rAkZNxDoT
CNN International@cnni·
The seaside town of Harlech in Wales is now home to the world's steepest street, Guinness World Records has ruled https://t.co/Of7d865wKv
The seaside town of Harlech in Wales is now home to the world's steepest street, Guinness World Records has ruled https://t.co/z8FZSmEIsa
Hootsuite@hootsuite·
What's the easiest way to increase your social media reach? Employee advocacy 🗣Download this toolkit: https://t.co/GlXmqCICFB and find out how easy it can be
The Wall Street Journal@WSJ·
Justice Stevens's public profile was modest, but in his impact on American life, few jurists could match his legacy https://t.co/qpwe4quxOh