You felt your baby kick, prepared your baby's room and imagined how life would be with a new little person in it – even before your child was born, the bonding process was happening. Your newborn already recognised your smell, knew your voice and found comfort in your warmth and the rhythm of your heart. Bonding between mother and child happens instinctively, but an emotional attachment only develops over time as you slowly get to know each other and start forming a close relationship.
The nature of attachment between you and your little one will make a lifelong difference to their experience of the world. If you respond consistently to your toddler's needs, have firm but fair boundaries and take pleasure in their company, they'll grow up feeling secure and loved. Neglect and constant criticism will result in an insecure child who distrusts others and believes they are essentially unlovable.
Spending one-on-one time with your toddler is the best way to get to know each other. Your little one's desire to be close to you 24/7 confirms that you're their favourite person in the whole world – their "go-to" person when all is not well. Hug your toddler, say "I love you" and tell them you believe in them. Knowing that they're your priority will give them the confidence to venture forth without you.
There are a host of fun bonding activities for parents and child that you can do with your toddler to bring you closer. Music and dance are creative and relaxing ways of expressing yourselves. Exercising together is energising and encourages healthy habits. You can find some fun game ideas in our Games and Activities for Toddlers.
Rituals such as family mealtimes or picnics in the park provide a sense of anticipation. Reading a bedtime story is ideal for cuddling up and can be part of a soothing bedtime ritual .
Being aware of your little one's natural temperament helps you to figure out how best to support them. Parenting a moody toddler requires more patience than an easygoing child. Be sensitive to your shy child's need for quiet time or your sociable toddler's need for stimulation. When your little one feels that you truly understand them, their self-esteem will blossom.


text:
Posted on May 25, 2020 by Wilmington News Journal
The Latest around the world: Spain to end quarantine for tourists on July 1
The Latest on the coronavirus pandemic.
MADRID — Spain says it will lift a 2-week mandatory confinement for all travelers arriving from overseas starting July 1.
The government said in a brief statement that Cabinet ministers made the decision to lift the mandatory quarantine during a meeting Monday.
Prime Minister Pedro Sánchez had already announced over the weekend that his nation was ready to welcome some foreign visitors in July.
The government is looking to establish safe corridors between parts of Spain that have the outbreak under control and similar areas in Europe that are an important source of tourists. There has been no talk so far of reopening to travelers from outside the European Union.
Spain is one of the world's most visited countries, attracting over 80 million international tourists each year. The industry represents 12% of Spain's GDP and employs 2.6 million people. Its economic importance is even greater on Spain's Canary and Balearic archipelagos.
BEIJING — The Chinese city of Wuhan has conducted more than 6.5 million coronavirus tests over a 10-day period in a bid to test all its 11 million residents, state media said Monday.
The city's health commission, in a post on its website, asked anyone who hasn't been tested to come forward by the end of Tuesday.
No new COVID-19 cases have been reported since the 10-day campaign started, though some people with no symptoms tested positive. More than 3 million people had been tested prior to the campaign, the official Xinhua News Agency said.
The campaign was launched after a cluster of six cases was discovered in one residential compound. Wuhan, where the global pandemic is believed to have started late last year, was by far the city hit hardest in China.
RAMALLAH, West Bank — The Palestinian prime minister says the West Bank will reopen on Tuesday after a dramatic slowdown in the spread of the coronavirus.
Prime Minister Mohammed Shtayyeh said shops, restaurants and mosques and churches would reopen on Tuesday, while government offices would reopen on Wednesday following the Muslim holiday of Eid al-Fitr.
The Palestinian Authority, which administers autonomous areas of the Israeli-occupied West Bank, imposed a strict lockdown in March.
The Palestinians reported 368 cases of COVID-19 in the West Bank, with two deaths.
TOKYO — Japan Prime Minister Shinzo Abe says his government will compile a fresh stimulus package worth about 100 trillion yen ($930 billion) to provide financial support for companies hit by the coronavirus pandemic.
Abe unveiled the new stimulus at a news conference Monday as he declared an end to a coronavirus state of emergency across the nation, as he removed the measure in five remaining prefectures including Tokyo.
Abe said a Cabinet approval of funding for the additional stimulus package is expected later this week.
The package would bring the amount of spending to more than 200 trillion yen ($1.9 trillion), he said. The government earlier compiled a 117 trillion yen stimulus package.
Japan, with about 16,600 confirmed cases of COVID-19 and about 850 deaths, has so far avoided a large outbreak like those experienced in the U.S. and the Europe despite its softer restrictions.
But the world's third-largest economy is fallen into a recession, and public discontent over Abe's handling of the coronavirus has sent his support ratings tumbling.
KYIV, Ukraine — The subway in Kyiv and kindergartens all across Ukraine reopened on Monday as the country moved to the second stage of easing lockdown restrictions.
Last week, Ukraine's government announced shifting to "an adjustable lockdown," with authorities in different regions deciding which restrictions to lift. The new regime started on Saturday, with public transport, hotels and churches reopening, and will remain in place until June 22.
In Kyiv, the subway returned to its usual schedule, allowing people in if they wear masks and observe social distancing guidelines. Churches across the country resumed public services on condition of enforcing social distancing. Hotels were allowed to reopen with their restaurants remaining closed.
Ukraine was one of the first ex-Soviet nations to impose a strict nationwide lockdown in March, when it had just a handful of coronavirus cases. It has so far reported 21,245 confirmed infections and 623 deaths.
VIENNA — Austria's government says it has agreed upon a one billion euro ($1.1 billion) package to support cities and municipalities struggling through the coronavirus pandemic.
Finance Minister Gernot Bluemel said Monday the money will be used to help kindergartens, schools and public transit systems, as well as projects like energy-saving measures, building renovations and the expansion of broadband connections.
Bluemel says the money will be distributed according to the size of cities.
Austria has registered 16,539 cases of the new coronavirus with 641 deaths.
LONDON — A hospital in southwest England says it has stopped accepting patients because of a rise in the number of COVID-19 cases it is treating.
Weston General Hospital in Weston-super-Mare says it is temporarily closing its admissions department "to maintain patient and staff safety." People are being sent to nearby hospitals for treatment.
Local lawmaker John Penrose tweeted that the hospital had had "a spike in infections" and would get a "deep clean" before reopening.
Nationally, the number of people hospitalized with the coronavirus is falling. The British government says there are 8,951 people in hospitals with COVID-19, down from 10,085 a week ago.
PRAGUE — A coal mine in northeastern Czech Republic near the border with Poland has halted work after a major COVID-19 outbreak among the miners.
In recent days, tests of some 2,400 people revealed a total of 212 positive for coronavirus, mostly miners from the Darkov mine in the town of Karvina and their family members. It's currently the biggest local outbreak in the country.
Ivo Vondrak, the head of the regional government, said Monday that only workers who are necessary to deal with ventilation and water pumping remain in the mine.
Local health authorities have limited public gatherings in Karvina county to 100, while it is 300 in the rest of the country. Visits to nursing homes and hospitals are banned
The daily increase of confirmed COVID-19 cases in the entire Czech Republic was 65 on Sunday. A total of 8,957 people have tested positive in the country, while 315 have died.
SEOUL, South Korea — South Korea says it plans to send 370,000 face masks to tens of thousands of South Korea-born adoptees living in the West to help them weather the coronavirus.
The Foreign Ministry said its diplomatic missions will work with dozens of international adoptee groups to distribute the masks to adoptees in 14 countries, including the United States, Canada, Australia and European nations such as Britain, Germany, France and Italy.
The ministry said it initially planned to send 100,000 masks but decided to expand the supplies because most South Korean adoptees were sent abroad as infants during the 1970s and 1980s and are now old enough to have their own children.
South Korea has been a major source of babies for Western adoptive parents since the end of 1950-53 Korean War. According to official figures, there are around 167,000 South Korean adoptees living abroad, including 110,000 in the United States. But experts say the actual number would be closer to 200,000.
South Korea is also in the process of sending 1 million masks to foreign veterans of the Korean War.
MADRID — Spain is making progress on its staggered plan out of the confinement against the new coronavirus.
Roughly half of the population, including residents in the biggest cities, Madrid and Barcelona, are entering phase 1 on Monday, which allows social gatherings in limited numbers, restaurant and bar service with outdoor sitting and some cultural and sports activities.
"It is all very strange but we missed this," María Cámara said as she enjoyed a morning breakfast in a central Madrid terrace for the first time in over two months.
Cámara and her partner, both warehouse workers, had turned the morning coffee in a bar into a routine followed religiously after long night shifts. "We really noticed not being able to do this," she said. "We went for a walk instead. But this is great."
Beyond hand sanitizer, masks and tables separated by social distancing norms, coffee bar owner Roberto Fernández said that the saddest novelty is those old customers who won't show up anymore.
"We are also a little sad today, as we have lost two of our more elderly regular customers," Fernández said. "They used to come every day but now they have left us."
The other half of the country, provinces with fewer infections or ready to face a possible second outbreak, are going one step further in loosening up restrictions. That includes no time limits on outdoor activities, meetings of up to 15 people, weddings, and visits to nursing homes and beaches. Some vocational schools in the Basque country are also resuming classroom activity.
DAMASCUS, Syria — Syria's Health Ministry is reporting 20 new cases of coronavirus in the country, the highest daily count since the new virus was first reported here in late March.
Monday's announcement raises to 106 the number of confirmed cases. There have been four deaths.
The ministry said all 20 new cases are of Syrians who returned from abroad. They comprise 15 people who came back from Kuwait, three from Sudan, one from Russia and one from the United Arab Emirates.
Syria recently began easing restrictions imposed over the past weeks.
Earlier in May, President Bashar Assad issued a decree postponing the country's parliamentary elections until July — the second such delay in light of restrictions in place to combat the spread of the coronavirus.
BERLIN — A coronavirus outbreak linked to a slaughterhouse in the Netherlands has spread across the border to Germany.
Dutch regional health authorities said Monday that tests showed 147 of the 657 employees at a meat processing plant in Groenlo were positive for COVID-19.
They said 79 of those infected live in Germany, while 68 are resident in the Netherlands.
There have been several clusters of COVID-19 among slaughterhouse workers in Germany in recent weeks, prompting a government pledge to crack down on conditions in the industry. Many workers in German abattoirs are migrants from Eastern Europe employed by subcontractors. They often live in shared housing and are transported to and from the slaughterhouses by shuttle bus, increasing the likelihood of infection.
PODGORICA, Montenegro — Montenegro's health minister has urged citizens to help keep the small Balkan country "corona-free" in the future after authorities said there are no more cases of infection at the moment.
Minister Kenan Hrapovic on Monday described the current situation in the country as a joint success of the health authorities and the citizen of Montenegro.
The Public Health Institute said Sunday that all of the 140 tests in the past 24 hours were negative and that there are no people currently reported sick with the virus.
Hrapovic says "responsible behavior and joint health care will be out trump card in the days ahead so that we can remain proud bearers of the title of a corona-free country."
The Balkan country of some 620,000 people imposed strict lockdown measures to curb the outbreak. A total of 324 cases have been recorded and nine people have died.
ATHENS, Greece — Greece on Monday restarted regular ferry services to the islands, while restaurants and bars were also back open for business as the country accelerated efforts to salvage its tourism season.
Travel to the islands had been generally off-limits since a lockdown in late March, with only goods suppliers and permanent residents keeping access.
But the country's low infection rate in the COVID-19 pandemic has prompted the government to start the holiday season earlier than expected, on June 15, as other Mediterranean countries — including Italy, Spain, and Turkey — are grappling with more deadly outbreaks.
Distancing regulations and passenger limits have been imposed on ferries and at restaurants, while state-run health services to combat new coronavirus cases are being expanded to the islands, with intensive care space being provided on five islands: Lesbos, Samos, Rhodes, Zakynthos, and Corfu, along with existing facilities on the island of Crete.
Tourism is a vital part of the Greek economy, with a direct cash contribution of more than 10%, and broad secondary benefits. More than 34 million visitors traveled to Greece last year, spending 18.2 billion euros, according to central data.
Hi! A visitor to our site felt the following article might be of interest to you: The Latest around the world: Spain to end quarantine for tourists on July 1. Here is a link to that story: http://www.wnewsj.com/news/137522/the-latest-around-the-world-spain-to-end-quarantine-for-tourists-on-july-1

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Two chef nodes (two environments) on one machine We are resource limited here, and want our qa and staging environments on one machine.
We are going to run separate binaries and confs for our app & supporting services.
According to chef docs it is possible to have a single machine be two nodes.  It just never explains how.
Much appreciated!

A: You'll need to execute chef client with an alternative configuration. The default config file and directory is /etc/chef/client.rb. You could use that one for one of the nodes / environments. Let's assume that will be "staging". You should probably make sure the node and environment are set up for the proper values:
node_name "mynode.staging"
environment "staging"

The other you could create such as /etc/chef/qa/client.rb for your qa configuration. In order to avoid conflict, you'll need to change the various configuration values for Chef that point in /etc/chef, and /var/chef.
See the Chef Configuration Settings wiki page for a complete list of configuration settings you can modify.
You should use the node_name and environment values similar to the staging environment. When you run chef, specify the alternative configuration file.

chef-client -c /etc/chef/qa/client.rb

redpajama_set_name: RedPajamaStackExchange


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text:
Hidden Plymouth
Plymouth's labyrinth of alleyways that lead to a secret garden
An inconspicuous passageway opens out to reveal a hidden gem: courtyards, box hedges and even a fountain; all beautifully designed to recreate a 17th-century garden
Rachael AtkinsReporter
The Elizabethan Gardens on the Barbican (Image: John Allen)
The labyrinthine alleyways of the Barbican hold a myriad of surprises. One of their best-kept secrets is hiding behind New Street; the Elizabethan Gardens.
This green space, surrounded on all sides by the Barbican's historic buildings, is so well hidden that surprisingly few people ever find it.
Potential garden visitors are easily spotted, peering tentatively into any likely alleyway for the garden's entrance. The reward of finding the gardens is all part of their charm.
But for those of you who'd much rather cut to the chase, here's the cheat's guide: Walking down Southside Street towards the Barbican you'll come to Stokes Lane on your right. Walk up the lane and when you reach the end look right. You'll see the Elizabethan Gardens sign on the wall; the entrance is directly below it.
An inconspicuous passageway opens out to reveal a hidden gem: courtyards, box hedges and even a fountain; all beautifully designed to recreate a 17th-century garden.
You'll find no chaotic explosions of wildflowers here. This garden is restrained and regal. Regimented, straight borders keep their colourful, floral captives in check.
The name is something of a red herring; the gardens were actually established in 1970 to celebrate 350 years since the Pilgrims left for America aboard the Mayflower.
The area was architected by Alan Miller Williams and constructed by Cooper Construction and David Colwill. Great care has been taken to ensure all the flora are historically accurate; nothing was planted that didn't exist in Britain before the 1600s.
The garden is made of several different gardens leading into each other; rose garden, knot garden, fountain courtyard and the sheltered mulberry tree courtyard.
From the New Street entrance you'll first enter the lower garden. This smaller area features old familiars: honeysuckle, hibiscus, hazel, hedgehog holly, lilac, silver birch and mock orange.
A set of stone steps leads to the central garden.
On the wall is a plaque naming the men and women who sailed into the history books aboard the Mayflower.
The garden is made of several different gardens leading into each other
A beautiful black mulberry tree is the centrepiece of the main courtyard. King James I imported thousands of these trees in the 17th century. He had a cunning plan to establish silk production in England – silkworms will only eat mulberry leaves. Unfortunately, the worms were unimpressed and the King's plan failed but the mulberry tree had taken root; now even the Queen has a national collection at Buckingham Palace.
You'll find a small, stone gazebo to rest your feet here and many stone benches dotted around the gardens to recline and enjoy the peaceful atmosphere.
Heading left at the mulberry tree, a small fountain trickles peacefully in front of the Castle Street entrance to the gardens. The doorway features the crest, lintel and arch of the Hospital of the Poor's Portion that once stood in Catherine Street 200 years ago. Further ahead lies the knot garden.
Intricately-planted box hedges, no more than a foot high, weave together in a symmetrical pattern. The design was popularised by the Tudors and features in many 17th-century gardens that survive today. Gorgeous beds of rosa and honeysuckle provide splashes of red and yellow to the formal arrangement in the flowering season.
The Elizabethan Gardens are full of little details. Another feature to watch out for is the stone carving of the Mayflower above the partition wall.
Intricately-planted box hedges, no more than a foot high, weave together in a symmetrical pattern
The Plymouth Barbican Trust owns and maintains the site. Volunteers tend to the borders and pathways to maintain the gardens, which are always tidy and clean.Standing in this quiet space, you truly feel you've found a secret garden. Described by many as a peaceful oasis, it's almost impossible to believe you're in the middle of the city here; birdsong and the gentle rustle of the wind through the tree branches is all you can hear.
The authentic Elizabethan planting and architecture draw you back through time – to when Sir Francis Drake and Sir Walter Raleigh lived and breathed in the streets of Plymouth.The gardens could so easily have been a 1950s housing estate. By the turn of the century the street had fallen into ill repute and disrepair. In 1926, No. 32 was scheduled for clearing until several prominent MPs, including Lady Astor, formed the Old Plymouth Society and saved the building – you'll know it today as the Elizabethan House.
The Plymouth Barbican Trust owns and maintains the site. (Image: John Allen)
But, the Barbican wasn't safe yet. It's a well-known tragedy that local authorities destroyed more Tudor properties in the ten years before WW2 than the ensuing bombings did. This destruction continued for another 12 years after the war when the Government announced grants for every building demolished.
Finally, in 1957, Plymothians had had enough and the Plymouth Barbican Trust was formed with a portfolio of buildings saved from destruction which they maintain to this day. The Elizabethan Gardens show a fantastic glimpse of the Plymouth that once was.
This article was first published in 2014
frontpageThe Prime Minister says he is looking forward to welcoming world leaders to this 'great region'


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text:
Sandra Nasic (* 25. května 1976, Göttingen, Německo) je zpěvačkou rockové skupiny Guano Apes. Po otci zdědila chorvatské kořeny.

Sandra studovala střední školu v Göttingenu a dále se chtěla věnovat studiu designu a umění na univerzitě. V roce 1994 se však setkala se svými budoucími spoluhráči, kteří hledali vokál pro založení skupiny.

Guano Apes
Guano Apes koncertovali v Evropě, Americe, získali cenu MTV Music Awards. Ve druhé polovině roku 2003 ohlásila kapela roční pauzu, poté vydala album živých nahrávek Live, druhé DVD a dokonce se mluvilo i o vydání Best of.

Přišlo dlouhé čekání, během kterého se rozhoduje o budoucnosti kapely. Ani ne po roce však opět hráli na některých z evropských festivalů. Později ale Guano Apes řekli, že na festivalech šlo o "naše poslední společné koncerty". Na konci října 2004 oznámili vydání nového singlu, Best of alba Planet of the Apes a podrobnosti o chystaném menším turné po Německu – oficiálním rozloučení před jejich konečným rozpadem.

V roce 2004 Sandra v rozhovoru s Magazínem OK! řekla: "Poslední dobou to bylo hodně těžké, často jsme se hádali a pořád přemýšlíme, co dělat a jak pokračovat dál. Momentálně jsme na tom ale tak, že možnost rozpadu je vcelku reálná. Ale ať už se stane cokoliv, potřebujeme si od sebe navzájem odpočinout. Pokud se v budoucnosti zase sejdeme, bude to fajn, ale pokud ne, taky v pohodě."

Na otázku, jak to bude po případném rozpadu kapely se vztahy mezi jejími členy, odpověděla: "Pokud tím myslíte, jestli je budu pořád respektovat, pak ano, ale opravdovými přáteli jsme nikdy nebyli. Ti tři o sobě věděli všechno už od střední školy a já byla vždycky trochu stranou. Po nějaké době jsem si na to ale zvykla, stejně jako na ně samotné. Už jsem dost stará na to, abych si to nějak moc nebrala, ne?"

Ve stejném rozhovoru dále řekla, že ona, Dennis Poschwatta, Henning Rümenapp a Stefan Ude jsou čtyři naprosto odlišné osobnosti a sama se diví, že to spolu vydrželi tak dlouho.

V roce 2010 po dlouhých sedmi letech kapela ohlásila návrat a 4. dubna vydala album Bel Air.

Přehled alb Guano Apes
 Proud Like a God (1997)
 Don't Give Me Names (2000)
 Walking on a Thin Line (2003)
 Live (2003)
 Planet of the Apes (best of; 2004)
 Bel Air (2011)
 Offline (2014)

Další tvorba
Ještě v době existence Guano Apes nahrála Sandra i další skladby:
 Path vol.II se skupinou Apocalyptica
 A Very Loud Lullaby s T. Raumschmmierem
 Beat of Life s DJ Tomekkem

Sólová kariéra
Po rozpadu Guano Apes v únoru 2005 si Sandra téměř celý rok dopřávala volno. Až do ledna 2006, kdy konečně podepsala smlouvu s GUN Records, nikdo vlastně nevěděl, co se s ní stalo. Poté ohlásila začátek prací na svém prvním sólovém albu, které si sama vyprodukovala.

Dne 21. září 2007 vydala singl Fever a o týden později, tedy 28. září 2007, i dlouho očekávané album The Signal.

The Signal
Skladby z alba balancují mezi rockem, electrem. Jedná se o tyto skladby:
 The Name Of My Baby
 Sorry
 Right Lane
 Fever
 Mecasanova (Yam Yam)
 Do It Again
 Stop The Crying
 Old Shack
 Big City
 Perfume
 The Signal
 Counting Trees
 Ireen
 Fever (Video)
 The Name Of My Baby (Video)
Skladba "Ireen" a videozáznamy "Fever" a "The Name Of My Baby" dostupné pouze v limitované rozšířené verzi

Reference

Externí odkazy

 Oficiální web
 Oficiální prezentace na MySpace
 SandraNasicFans.com

Německé zpěvačky
Hudebnice alternativního rocku
Narození v roce 1976
Žijící lidé
Narození 25. května
Ženy
Narození v Göttingenu
Metalové zpěvačky

redpajama_set_name: RedPajamaWikipedia


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We build clearly defined apps, websites and the infrastructure that supports them.
LightStart, the digital design house, was founded by Simon Edwards and Dan Akers in mid-2016. We build digital products for our clients including mobile apps, web apps and the underlying platforms that drive them. Our core team has 45 years of experience building and launching digital products.
LightStart was created in recognition of the fact that the current project delivery process employed by most agencies and developers is flawed, and gives most clients a pretty stressful experience. The process detailed in the Digital Project Lifecycle page is how we rectify this, based on our joint experiences of delivering digital projects over the last 20 years.
We position LightStart as a thought-leader at the forefront of the digital community in Yorkshire through our client projects and our own labs projects. In addition to this, we run free innovative events, and pride ourselves in it. We have an annual calendar of over 30 events, all of which are free to attend. For more information, see our events list here.
As well as building digital products for clients, we have created LightStart LABS to develop our own ideas and get them to market. The first of these products, Bookaroo, is due for launch in at the end of 2017.
Colin Glass OBE, founder of WGN and non-exec director of the British Business Bank, has now joined the team as a board advisor to act as a business mentor as we continue to scale.


text:
package com.amazonaws.services.simpleemail.model.transform;

import javax.xml.stream.events.XMLEvent;
import javax.annotation.Generated;

import com.amazonaws.services.simpleemail.model.*;
import com.amazonaws.transform.Unmarshaller;

import com.amazonaws.transform.StaxUnmarshallerContext;
import com.amazonaws.transform.SimpleTypeStaxUnmarshallers.*;

/**
 * ReorderReceiptRuleSetResult StAX Unmarshaller
 */

@Generated("com.amazonaws:aws-java-sdk-code-generator")
public class ReorderReceiptRuleSetResultStaxUnmarshaller implements Unmarshaller<ReorderReceiptRuleSetResult, StaxUnmarshallerContext> {

    public ReorderReceiptRuleSetResult unmarshall(StaxUnmarshallerContext context) throws Exception {
        ReorderReceiptRuleSetResult reorderReceiptRuleSetResult = new ReorderReceiptRuleSetResult();
        int originalDepth = context.getCurrentDepth();
        int targetDepth = originalDepth + 1;

        if (context.isStartOfDocument())
            targetDepth += 2;

        while (true) {
            XMLEvent xmlEvent = context.nextEvent();
            if (xmlEvent.isEndDocument())
                return reorderReceiptRuleSetResult;

            if (xmlEvent.isAttribute() || xmlEvent.isStartElement()) {

            } else if (xmlEvent.isEndElement()) {
                if (context.getCurrentDepth() < originalDepth) {
                    return reorderReceiptRuleSetResult;
                }
            }
        }
    }

    private static ReorderReceiptRuleSetResultStaxUnmarshaller instance;

    public static ReorderReceiptRuleSetResultStaxUnmarshaller getInstance() {
        if (instance == null)
            instance = new ReorderReceiptRuleSetResultStaxUnmarshaller();
        return instance;
    }
}

redpajama_set_name: RedPajamaGithub


text:
Home Lifestyle How AI Is Transforming Drug Discovery
How AI Is Transforming Drug Discovery
sankulasati December 26, 2022 December 26, 2022 3 min readWrite a Comment on How AI Is Transforming Drug Discovery
AI Drug Discovery Platforms are the new wave in drug development. These platforms combine computerised technologies to speed up the process of finding novel drugs and providing personalised care for patients.
The drug discovery process is a long one. Before a medicine can be made, sold, or tested, the hit compound must first be found. The selection process is every bit as important as its optimization.
Pharmaceutical companies are increasingly partnering with AI-powered biotech companies, Contract Research Organisations, and AI-drug discovery platforms. The most successful outcomes arise when this state-of-the-art technology is combined with high-quality data.
Choosing the right AI drug discovery platform is critical
The stages in drug discovery begins as a research hypothesis: that a drug with a specific effect — such as modulating a specified protein channel — will be beneficial in the treatment of some disease. The search begins. And so, Guido was lucky to find one with the right effect. But fundamentally, finding that compound can take far more time and resources than most of us have. So choosing the right platform to bridge the gap is critical.
In drug discovery, advances in machine learning and data have revolutionised entire fields. To truly maximise their impact, approaches are needed that adequately address the complexity of patterns observed in the lab, in animal models, and hopefully in humans. Most off-the-shelf approaches have made high-profile impacts in image recognition; however, these approaches are seldom relevant in spaces where the data is often multifaceted, not well understood, expensive to collect and highly biassed. In essence recognizing a cat in a photo is fundamentally different than winning at go, designing a drug is fundamentally different than recognizing high level features of atoms or molecules.
In recent years, machine learning has helped scientists better predict the activity of molecules in various biological systems. While machine learning has been used in drug discovery before, it is only recently that the technology and data have caught up. "Models are better, algorithms are better, better datasets, better computational resources…We're really just starting to see the potential of that on drug discovery projects now, and it's going to play a big part of what we do in the future,"
AI-Enabled Drug Discovery Solutions
AI drug discovery platforms, such as Valo and others, can now be used by CRO services to offer services that are far more efficient. By integrating their laboratory capabilities with Valo's AI platform, they have demonstrated the ability to produce advanceable lead series at cost-effectiveness exceeding 90%.
AI is a tool that can also be used as an augmentation for, or instead of, humans. The use of AI in drug discovery has already begun and will continue to reach new levels of sophistication and accuracy. There's no doubt that we'll see this technology applied to human problems, from medical diagnosis to life-saving treatment, but for now, the focus remains on finding cures for novel diseases.
Lanza's project is looking to identify compounds with similar biological properties and targets as the original drug. He started by creating a model that allowed him to identify all compounds in the data set with similar pharmacological profiles. This was then used with a separate model that identified any compound that has ever gotten into the brain.
Tagged InCRO services stages in drug discovery
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MIAMI, Fla. -- The Coast Guard has almost doubled its coverage area on the second day of a search for a Texas man who fell from a cruise ship near Florida's Key Largo.
Coast Guard officials said Sunday they have expanded their search to 1,676 square nautical miles.
Coast Guard officials say 46-year-old David Mossman fell from the 10th deck of the Navigator of the Seas ship early Saturday, a distance of about 100 feet.
The Coast Guard says in a news release that a helicopter and plane are being used in the search.


text:
Trinity's Cassie Felder named Commended Student
About 34,000 Commended Students throughout the nation are being recognized
Trinity's Cassie Felder named Commended Student About 34,000 Commended Students throughout the nation are being recognized Check out this story on montgomeryadvertiser.com: http://on.mgmadv.com/1wiXvbF
MGM Published 5:54 p.m. CT Oct. 21, 2014 | Updated 6:16 p.m. CT Oct. 21, 2014
Cassie Felder (Photo: Contributed)
Cassie Felder has been named a Commended Student in the 2015 National Merit Scholarship Program.
About 34,000 Commended Students throughout the nation are being recognized for their exceptional academic promise. Although they will not continue in the 2015 competition for National Merit Scholarship awards, Commended Students placed among the top five percent of more than 1.5 million students who entered the 2015 competition by taking the 2013 Preliminary SAT/National Merit Scholarship Qualifying Test.
"The Young men and women being named Commended Students have demonstrated outstanding potential for academic success," commented a spokesperson for National Merit Scholarship Corporation. "These students represent a valuable national resource; recognizing their accomplishments, as well as the key role their academic development, is vital to the advancement of educational excellence in our nation. We hope that this recognition will help broaden their educational opportunities and encourage them as they continue their pursuit of academic success."
Read or Share this story: http://on.mgmadv.com/1wiXvbF


text:
Panzer I - El Inicio de Una Saga...
by: Jim Rae [ JIMBRAE ]
Introduction..
Quiron Ediciones is a small Spanish publishing house, who, in the last few years, have built up an excellent reputation for covering a wide variety of military subjects, in particular those related to the Spanish Civil War. This recent publication on the Panzer 1 fits perfectly within the compay remit, dealing, as it does, with a vehicle whose first 'baptism of fire' was in the brutal Spanish Civil war...
Quiron Ediciones new book...
Panzer I: El Inicio de Una Saga (Panzer 1 - the beginnings of a saga) is written by Lucas Molina Franco and consists of 64 pages in a slightly smaller than A4 format. The book is divided into five chapters:
Origins and development
The 'older brothers' - PzKfw 1 (ausf C & F)
The Command Vehicles - Kleiner Panzerbefehslwagen I, Ausf A & B
Special Versions of the Panzer 1 (Ausf A)
Special Versions of the Panzer 1 (Ausf B)
The book, and perhaps this is its strongest aspect is absolutely packed with photos and illustrations. The photos have ALL been digitally re-mastered with a crispness of definition and contrast which is frankly impressive. I have seen quite a number before in other publications, however quite a few are completely new... The color plates, (of which there are no less than 48) are some of the finest that I have seen. Particularly are has been taken in the accurate placement of unit markings and with this in mind, where applicable, front views are also provided.
The text, which is all in Spanish, is well written, concise and informative. Particularly well-done, is the introduction to the development of the vehicleand the notes on the various variants of the subject. Unfortunately, the fact that the book is written totally in Spanish, will put many people off. However, the real value for many modellers will be in the illustrative content. In my own library, I have an increasingly large number of Polish and Russian publications which I consider indispensable for their visual reference value. Quiron Ediciones really have to consider the international value of a book of this nature and at least, provide bilingual captions....
Two of the book's sections are particularly valuable for the modeller - the section on the 'Older Brothers' of the Pz I which covers in a number of images two of the later (1942) projects: the Ausf C & F. Both of these variants have many (superfical) similarities to the Pz II 'Luchs', particularly in the complex running gear. The other section, (which almost deserves a seperate volume) covers the fascinating subject of the Special variants of the Panzer I. Seven vehicles are covered from the well-documented Munitionsschleeper 'Laube' to the rare Panzer I Ausf A, 'Breda' of the Spanish Civil War.
This book is one of those invaluable 'additions' to a balanced library which, with other books will provide much inspiration for the many modelling projects which the Panzer lends itself to.
This book is a bargain. Twelve Euros for a book of this quality is frankly incredible. My only reservations are in the fact that the text is exclusively in Spanish. This will (sadly) put many potential purchasers off. However, that aside, the quality and value of the illustrations, more than compensates for this (minor) drawback. It can't be said that this is the definitive book on the Pz I, however it is a definite 'must-have' for anyone working on this most interesting of vehicles. The quality of reproduction is as good as I have seen anywhere and the author has demonstrated a great deal of imagination by choosing the subjects covered n the book. I will however say, that a second volume (or third?) would be a great asset, particularly dealing with the 'Special Purpose' vehicles and in paricular the Panzer I in the Spanish Civil War. In cases like this, it is difficult to find the superlatives necessary to do this superb publication justice...
VERY Highly Recommended
Further Details...
My example was purchased directly from the publishers, whose (bilingual) website, can be seen below:
Quiron Ediciones Website
Shortly, we will be publishing another feature in the Armor Resource Feature series, the subject of this latest 'instalment' will be the Panzer I and the many linked reviews which Armorama has published over the years....
Like many modellers, I have a strong interest in early-war German Armor. Personally I find it difficult to get very enthusiastic over the later German vehicles such as the King Tiger. The early/pre-war vehicles have (for me) an 'aesthetic' which is lacking in the later war vehicles. The modeller has, in general, been fairly well-served by the manufacturers in 1/35th scale: Tristar and Dragon have superb kits available with the Ukrainian manufacturer MasterBox Ltd providing a good range of variants. What is always welcome is more reference on this surprisingly complex subject - the PanzerKampwagen 1, the subject of this new and useful book...
REPRODUCTION OF B/W IMAGE: 50%
COLOR PROFILES: 90%
APPLICATION: 80%
Scale: 1:1
Mfg. ID: ISBN 84-95016-52-8
Suggested Retail: 12 Euros
About Jim Rae (jimbrae)
FROM: PROVINCIA DE LUGO, SPAIN / ESPAñA
Self-employed English teacher living in NW Spain. Been modelling off and on since the sixties. Came back into the hobby around ten years ago. First love is Soviet Armor with German subjects running a close second. Currently exploring ways of getting cloned to allow time for modelling, working and wr...
Copyright ©2019 text by Jim Rae [ JIMBRAE ]. All rights reserved.
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CounterCorp
Putting an end to business as usual
Corporate Crime Blotter
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Corporation Watch
Shining a Spotlight on Corporate Pathology
Submitted by CW Editor on October 19, 2010 - 1:56am
Welcome to the Corporation Watch blog, which offers analysis and commentary on articles from the mainstream and alternative media related to corporate power and influence, crimes and abuses, and culture and pathology around the world. CW also includes postings on the mythologies of orthodox economics, and the nexus between economic dogma, government policy, and corporate sociopathy.
Read more about Shining a Spotlight on Corporate Pathology
CW Editor's blog
Artful Dodgers
Submitted by Editor on May 25, 2013 - 12:29pm
Even as corporations have amassed ever-greater profits, they have managed to cut their total contribution to U.S. federal revenue (which includes their share of employee payroll taxes) roughly in half, from 32 percent in the early 1950s to about 17 percent today:
Read more about Artful Dodgers
Debunking the myth of corporate competence
Submitted by CW Editor on May 10, 2012 - 2:06am
Among the disservices performed by the media — and particularly the embedded reporters and editors who cover corporations — is perpetuating a myth that has become pervasive in the American (and to a large part, global) public consciousness: namely, that most corporations are efficiently managed by highly competent people making the best possible decisions on the basis of data, analysis, and professional experience.
But as is the case with most "facts" purveyed in the business media, this idea is based not so much on first-hand knowledge or observation, but rather through second-hand self-reporting from the CEOs and companies themselves, and is frequently disproven by later reports to the contrary that almost always appear long after the hagiographies have been inculcated.
Case in point: The announcement that faltering Internet pioneer Yahoo was replacing yet another CEO — this time for falsifying his academic credentials on his resume (which the company certified as true in an annual filing to the Securities and Exchange Commission) — which came just a few days after JPMorgan Chase CEO Jamie Dimon's admission that the company he runs had managed to lose at least $2 billion (which has since tripled to at least $6 billon) in an effort to "mitigate risk" in its investments (i.e., prevent it from losing money) using credit default swaps — the same volatile financial instruments that had been a key factor in the global economic collapse a few years earlier.
All of this all of this had a depressingly familiar ring to it, and echoed an article in the May 8 edition of Fortune magazine from James Bandler entitled "How Hewlett-Packard Lost Its Way", which offered yet another example of how even when the firmly embedded journalists of the business media finally bring themselves to report that the emperors of our economic aristocracy have no clothes, the myth of corporate competence and efficiency somehow always manages to resurrect itself and keep staggering on, like a hockey-masked killer in a horror movie.
Read more about Debunking the myth of corporate competence
Engineering consent
Submitted by CW Editor on February 13, 2012 - 8:24pm
Read more about Engineering consent
FCC 'shocked, shocked' that AT&T lied about merger with T-Mobile
Submitted by CW Editor on November 29, 2011 - 7:31pm
A draft report released by the Federal Communications Commission (FCC) on Nov. 29 found that AT&T's proposed merger with German-owned cellphone carrier T-Mobile would not be in the public interest because it would substantially reduce competition among the four top mobile phone providers and raise prices for consumers.
This followed similar findings from the U.S. Department of Justice, as well as public opposition to the deal from senior members of Congress, and was not a surprise. The real "news" in the report was the FCC's finding that AT&T had publicly lied about the benefits of its proposed merger with T-Mobile — telling the public, media, and federal regulators that the deal was necessary to modernize its wireless phone network and would lower prices and create more jobs*, while its internal documents showed that its public claims were untrue.
Read more about FCC 'shocked, shocked' that AT&T lied about merger with T-Mobile
The real meaning of 'Corporate America'
Submitted by CW Editor on July 25, 2011 - 6:22pm
Read more about The real meaning of 'Corporate America'
The Artful Dodger: GE picks the public's pocket in a Dickensian economic system
Submitted by CW Editor on March 25, 2011 - 7:06pm
A March 24 NY Times article headlined "GE's Strategies Let It Avoid Taxes Altogether" described how General Electric, the nation's largest corporation, reported $14.2 billion in 2010 global profits, including $5.1 billion from its operations in the United States, yet not only paid absolutely zero U.S. taxes, but actually claimed a tax benefit of $3.2 billion.
Reporter David Kocieniewski notes that "low taxes are nothing new for GE", and are the result of "an aggressive strategy that mixes fierce lobbying for tax breaks with innovative accounting that enables it to concentrate its profits off-shore. GE's giant tax department, led by a bow-tied former Treasury official named John Samuels, is often referred to as the world's best tax law firm".
According to Kocieniewski, nearly a thousand GE employees spend at least half their time exploiting an already porous tax code that allows corporations to avoid paying taxes on income from certain kinds of financial operations abroad, and then use tax credits, write-offs, and depreciation from those activities to off-set taxes on domestic profits.
"But critics say the use of so many shelters amounts to corporate welfare", the article says, and that "the assertive tax avoidance of multinationals like GE not only shortchanges the Treasury, but also harms the economy by discouraging investment and hiring in the United States".
Read more about The Artful Dodger: GE picks the public's pocket in a Dickensian economic system
The personal is political: Bipolar court says Jekyll-and-Hyde corporations are persons — except when they're not
Submitted by CW Editor on March 4, 2011 - 5:42pm
On March 1, 2011, the Supreme Court issued a unanimous ruling in the case known as Federal Communications Commission v AT&T, finding that corporations cannot assert personal privacy rights, at least insofar as Freedom of Information Act (FOIA) requests for government documents relating to corporate actions are concerned.
The case stems from a FOIA request by AT&T's competitors for documents the had FCC compiled during a 2004 investigation into claims that the recombinant communications behemoth had over-charged schools and libraries for their access to and use of the Internet.
Despite a series of legal findings against it in recent years, and unlike an actual human repeat offender, AT&T were as usual allowed to buy their way out of what amounted to a charge of defrauding the government — which any real human recidivist would likely have been convicted of and gone to jail for — by paying a mere $500,000 fine to settle the case without admitting any wrong-doing.
Read more about The personal is political: Bipolar court says Jekyll-and-Hyde corporations are persons — except when they're not
"Live" cartoon on the roots of the financial crisis
Submitted by CW Editor on February 22, 2011 - 12:33pm
CUNY professor David Harvey gave a presentation in April 2010 to the Royal Society for the Encouragement of Arts, Manufactures, and Commerce (only in Britain could they name something that, right?) called "The Crises of Capitalism", which the RSA then had animated. The result is sort of a "live" cartoon in which Harvey's words are both literally and figuratively animated as he speaks:
Read more about "Live" cartoon on the roots of the financial crisis
How about a holiday from corporate extortion?
Fortune features a Feb. 16 article by Tory Newmyer about how large multi-national tech, pharmaceutical, and energy corporations such as Oracle, Cisco, Apple, Duke Energy, and Pfizer are lobbying vociferously for a one-year so-called "tax holiday" that would allow them to bring roughly $1 trillion in profits from their overseas operations back to the United States at a 5 percent tax rate instead of the "official" rate of 35 percent.
There are so many things wrong with this proposal — and the underlying issues — that it's hard to decide where to begin. But let's start by considering the mafia-like extortion by which these corporations are refusing to bring money back to the U.S., unless they pay only a token amount of tax on it (i.e., "Do what we say or you'll never see your money again"). Or the fact that President Obama's proposed budget contains a structural deficit estimated at roughly $1.5 trillion, and taxing that overseas corporate stash at 35 percent would instantly cut that deficit by $350 billion.
Read more about How about a holiday from corporate extortion?
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Title: Artful Dodgers
Title: Debunking the myth of corporate competence
Title: Engineering consent
Title: FCC 'shocked, shocked' that AT&T lied about merger with T-Mobile
TBA: Our first film screening in Providence, RI. Stay tuned!
2019: New series of film screenings in Providence and the Northeast U.S.
TBD: Launch of CounterCorp membership program to coincide with new film program
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