Heartbroken, but yet so much joy.
We started our day off at 6 AM by attending a worship service at Church on the Rock. It was powerful and humbling to be blessed to witness the expressive and dedicated faith that the Haitian people have for God. It was an excellent start to our day! It brought us so much joy to be able to witness their faith.
Today was also an emotional day for our team. Torn between heart break and overwhelming joy... Today was our first and only water truck day. We delivered 12,000 gallons of clean drinking water to Cite Soilel, the poorest slum in our hemisphere. The joy is overwhelming because of the smiles and thankfulness... But the brokenness is deep knowing the depths of their circumstances.
We want to do so much, yet we can't do anything. By partnering with Healing Haiti we are helping their mission and therefor helping and healing Haiti.. But our hearts crave more! We desire to be able to serve more and give more.
"Father, we come to you and ask for your peace. We ask you to wrap us up in your comfort where we can trust that you will supply for the beautiful and precious people of Haiti. We know that you are God, we know that you know the depths of their despair and every need they have. You know them by name and you know their hearts because you are the Creator of all. We ask you Father to make your presence so apparent in their lives. Keep their faith strong. Keep them close to your heart. Thank you for blessing this team with the opportunity to love these people with all we have. Thank you God for breaking our hearts for what breaks yours. Our hearts are truly broken for our brothers & sisters in Christ here in Haiti. Please continue to pour out your love and compassion over them. We love you Father, thank you for watching over them and continuing to move mountains in their lives every single day. In Jesus name, Amen."
Our words of the day were: Love, possibilities, reliance, blessing, Holy Spirit, supplier, thirsty, hands, hungry, humbly, stinkin', dedication, worship, and caring.


Zhongshan District is a fantastic choice for tourists keen on gourmet meals, culture and helpful locals.
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Cebu Town (Cebuano: Dakbayan sa Sugbu; Filipino: Lungsod ng Cebu) could be the money town in the island province of Cebu in Central Visayas and is particularly the "2nd town" in the Philippines after Manila. Cebu City is actually a 1st town profits class remarkably urbanized city in which its political governance is unbiased and independent with the province of Cebu, and according to the 2015 census, it's a population of 922,611, rendering it the fifth most populated city while in the country.
To Circa 1900 (Chef Steve and Wife, Adrian and Rhey 菲律賓遊學代辦 and to the remainder of the workforce) There isn't a question on why this cafe is among the finest Eating places in Cebu. The ambiance, the excellent company and many Specifically the extraordinary food stuff they provide equates to a great here eating expertise. When we ended up nevertheless scheduling for the meals caterer and an awesome venue for a marriage, Circa was our prime choice and we under no circumstances regretted it.


Add sunshine to your day using the Summer Vibes Collection Decorative Brads by Simple Stories. Included in the package are 13 self-adhesive decorative Bradz with attitude.
these are adorable. they were much better than i ever expected. great for using on cards or anything else u can think to use them on. great quality, scrapbook is a great place to buy your scrap booking items from. they are very quick at shipping your stuff out.
I absolutely love that these are self-adhesive brads! I've always avoided using brads because punching through layers of paper and/or cardstock can be a real pain. I've always ended up wrinkling or creasing my layout in the process. Not a good thing when you're picky. So when I saw that there were self-stick brads available, I was all over it. I love the dimension they give, and they just stick on the page. Awesome! The only reason I didn't give them 5 stars is the picture here on the website shows more vivd images than they are in person. If the brads were as vibrant in hand as they appear here, they would've gotten that last star.


ForumsX - I want Maxed out Graphics.
ForumsX > Video Game Discussion > StarCraft II Discussion > I want Maxed out Graphics.
I want Maxed out Graphics.
Okay, this game runs SLOW. Why? I've copied Blizzard's recommended specs assuming those are for max results, not the minimum specs.
So, I've got ram, I've got the processor, and my video card has a right number. But it is older. I think the answer is a better video card. But I'm surprised that I've got RAM and processor to spare. I've got the game running on bare minimums and I have to rush because the game gets too laggy to run towards the end of a game. Thoughts?
I find that the video card is often the key piece of the puzzle in cases like this.
After initial matches i got to platinum league! Hazzaz!
Your current video card memory, while sufficient on the MB side, is a bit out dated on the ram side. Yours has DDR2 which is fairly old school. Updating to a DDR3 or even better a DDR5 would give you quite a boost. Just make sure your power supply can handle it.
I've got similar Processor and RAM to you, and when I upgraded my video card I went from running on low settings, to Ultra with no prob.
My mind is made. New video card is coming soon.
All times are GMT -5 hours. The time now is 05:08 AM.


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Kinzie Things
FF romance
Holiday Story
lgbtqia content
M/F Romance
MMM Romance
own voices author
queer disneyland
read the trigger warnings
sexually explicit
About The Reviews
Why these categories?
Who Does The Reviews?
Books · Contemporary · Excerpt · giveaway · MM romance · my faves · part of series · Releases and Cover Reveals · self-discovery · sequel · sexually explicit
Release Blitz, Excerpt, Giveaway and Review! Bring To Light by C F White
16 Dec 2020 9 Dec 2020 charkinzie
Book Title: Bring to Light (London Lies #3)
Author: C F White
Publisher: C F White
Cover Artist: Etheral Designs
Genre/s: Contemporary M/M Romance, Romantic Suspense
Trope/s: Hurt/Comfort
Themes: Coming out
Heat Rating: 4 flames
Length: 79 000 words/358 pages
It is book 3 and the final part in the London Lies series.
Universal Link | Amazon US | Amazon UK
It's a race against time, with a deadline not only on their story or their growing relationship but on their entire lives.
Jackson Young and Fletcher Doherty are back in London and on a mission—to bring to light the murky underbelly of the Charles Payne media empire and, in doing so, get justice for the murder of Tallulah Payne.
It's not a simple task though. They need proof. They need people to speak up. And they need to keep their hands off each other long enough to track down the other manipulated Lotus Flowers, convince them to come forward and find a way to bring it all to the public. Not so easy when they're up against the most powerful men in London who are determined to separate and silence them by any means possible.
Jackson Young was a new man.
The sweet, shallow breaths trickling onto his neck were testament to that transformation. He shuffled back, his skin erupting delightful goosepimples that tingled and stirred and itched for him to beg for more. He refused to move. He couldn't bear to move. Nor to wake up. This was where he wanted to stay. Closed-in. Coddled. Safe. And wrapped up in arms and legs that clung to him like a limpet.
Like a lover.
The birds outside tweeted and morning light bled through the gaps in the blinds. Jackson wondered, for the few moments he now had to lie as content as he were, if he would ever get used to waking immersed in such nirvana. He hoped not. That would be admitting defeat. He would pray to never get used to having one of Fletcher Doherty's legs flung haphazardly over his hip, one of his arms draped over his chest, and his face nuzzling into his neck and inhaling him as though he was the cool morning air. Because this, right now, was perfection personified. His perfect moment. He never wanted to take it for granted. He'd discovered that there was life after the Jax. And if this was it, he never wanted it to end.
Because he could live like this forever.
However long that might be.
Fletcher jerked. Then, sliding away, he rubbed his eyes, and that miniscule movement declared the self-indulgence was over. Jackson remained where he was, facing away in the bed and curled up, hoping that Fletcher would forget what was lying in wait for them and sink back in beside him.
He'd never been this needy. Not for another man. But Fletcher was everything he'd ever craved wrapped up in everything he'd always desired. He was like the drink. The coke. The lights, camera, action that had fuelled his needs since the early years. Fletcher was his addiction. His lifeblood. His obsession. The air he needed to breathe.
But if Fletcher found out any of that, he'd make Jackson go cold turkey.
So he didn't say it. And he wouldn't say it. He muted himself.
The covers slipped from his body and he shivered. Fletcher rolled away, lifted, and checked the illuminated numbers on the digital clock. He then fell back to the pillows with a sigh and the scratching of fingertips down coarse facial hair indicated that any moment now, Fletcher would declare their peace and tranquility in the safe haven of a Surrey B&B had come to a bitter end.
As he would no doubt, any second now, say—
"Jackson?"
Jackson didn't respond. Nor move. He feigned the deepest of sleeps. If Fletcher was going to start the day, then Jackson wanted him to start it the right way. For them both.
Fletcher kicked him under the duvet. "I know you're awake."
That wasn't exactly what Jackson had had in mind. But he smiled, and with him facing away, Fletcher wouldn't be able to tell.
"Fecking eejit." Fletcher rolled back, clasped his arms around him and hauled him to his chest. Then, settling those soft, enticing lips of his to Jackson's ear, he rumbled a deep and guttural, "Get up."
Jackson twisted, falling into Fletcher's arms and attacked the moment to kiss him. "I'm up," he declared against the breath that he craved like he once had alcohol, and thrust his morning erection against Fletcher's.
No, he wouldn't ever get used to waking like this. He'd cherish it. And not take it for granted like he had every other morning of his life thus far. It might have been contrite. A tad inappropriate, perhaps. And not the time to be indulging in each other's arms. But if they couldn't do it now, when could they? Would they ever get to the point where they could be entangled in each other without the dark clouds looming over them? Without the threat? Without the fear and worry and everything else that had brought them together in the first place.
Relationships built under stress never lasted.
So like the meals he'd had to consume in a timely manner when incarcerated at HMP Flaymore, he wanted to get what he could, while he could.
"We have to get going," Fletcher breathed out between heated kisses.
"Then maybe just get me off?" Jackson asked the question with a hopeful lilt and a smidgen of jest by rutting himself forward. He shouldn't feel guilty about wanting to make up for lost time and living his life to the full now he knew what it was he wanted.
And what he wanted was the naked Irishman snuggled next to him and gripping him as though he was about to fall.
He had already, of course. But he couldn't say that. Not yet.
"Bring To Light" by C.F. White is the conclusion of the London Lies series and probably my favourite. What a journey Jackson Young and Fletcher Doherty have been on – and as a reader, I feel as though I've been on the roller coaster ride with them.
When this series begins, Jackson Young has been in jail for a crime he says he didn't commit. He stands accused of killing his partner and his life is in a shambles. In a last-ditch effort to try and salvage his reputation and his life, he contacted Fletcher… a gossip journalist.
This is the beginning of a rather epic mystery as the two men join forces to try and figure out who is behind the murder and other crimes that seem to follow Jackson everywhere. They set out to look for the truth and come to a tentative agreement to work together on the biography of Jackson Young. The intent of this is the set things right, get to the bottom of what has happened to Jackson and his friends and colleagues.
Over the course of this series, White has shown great skill at developing the main characters in this series. It's been great to read through these books and get to know Jackson and Fletcher…see how they have changed and watch as they have grown. White took full advantage of the length of the series to give these characters lives on the page that was engaging and enjoyable.
The story of Jackson's life is intriguing! There is a lot wrapped up in the mystery that extends throughout this series. What begins with a death and Jackson proclaiming his innocence goes on to become much larger. White does a great job of demonstrating how a person can be caught up in their fame to the point they aren't able to make healthy decisions. Jackson hasn't been able to trust anyone throughout his life really… perhaps he hasn't always been aware of that…but over the course of the series, he has come to realize he's adrift in life.
With Fletcher's help, his skill as a journalist and his natural curiosity… Jackson realizes that much of his life wasn't ever what he thought it was. I don't want to give away too much because one of the pleasures of reading this series for me was watching it all unfold. Fletcher is steadfast as he tries to get to the bottom of what's happened in Jackson's life. But his family and friends become involved because "the big bad" they are trying to take on has a long reach.
This is a great m/m romance series if you expect much more than just a romance! There's an engaging, cohesive and well-written storyline that runs consistently throughout the books in the series. I really enjoyed the series…and will gladly pick up anything by White in the future!
Brought up in a relatively small town in Hertfordshire, C F White managed to do what most other residents try to do and fail—leave.
Studying at a West London university, she realised there was a whole city out there waiting to be discovered, so, much like Dick Whittington before her, she never made it back home and still endlessly search for the streets paved with gold, slowly coming to the realisation they're mostly paved with chewing gum. And the odd bit of graffiti. And those little circles of yellow spray paint where the council point out the pot holes to someone who is supposedly meant to fix them instead of staring at them vacantly whilst holding a polystyrene cup of watered-down coffee.
Eventually she moved West to East along that vast District Line and settled for pie and mash, cockles and winkles and a bit of Knees Up Mother Brown to live in the East End of London; securing a job and creating a life, a home and a family.
After her second son was born with a rare disability, C F White's life changed and it brought pen back to and paper after having written stories as a child but never had the confidence to show them to the world. Now, having embarked on this writing journey, C F White can't stop.
So strap in, it's going to be a bumpy ride.
Follow C F White
Twitter @CFWhiteUK | Facebook | Blog
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"Another secret of the universe: Sometimes pain was like a storm that came out of nowhere. The clearest summer could end in a downpour. Could end in lightning and thunder."
― Benjamin Alire Sáenz, Aristotle and Dante Discover the Secrets of the Universe

redpajama_set_name: RedPajamaCommonCrawl


Should I pay origination points in exchange for a lower interest rate?
Origination points are considered a form of interest. Each point is equal to one percent of the loan amount. You pay them, up front, at your loan closing in exchange for a lower interest rate over the life of your loan. This means more money will be required at closing, however, you will have lower monthly payments over the term of your loan.
To determine whether it makes sense for you to pay origination points, you should compare the cost of the origination points to the monthly payments savings created by the lower interest rate. Divide the total cost of the origination points by the savings in each monthly payment. This calculation provides the number of payments you'll make before you actually begin to save money by paying origination points. If the number of months it will take to recoup the origination points is longer than you plan on having this mortgage, you should consider the loan program option that doesn't require origination points to be paid.


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Home Editor's Pick Ethnic diversity in Sabah needs to be honoured, preserved for future generation...
Ethnic diversity in Sabah needs to be honoured, preserved for future generation – Hajiji
TUARAN, Aug 21 — The diversity of ethnic groups found in Sabah needs to be honoured and preserved as a cultural heritage for future generations, says Sabah Chief Minister Datuk Seri Hajiji Noor.
He said there were about 30 ethnicities and 200 sub-ethnicities in Sabah that needed to be preserved, especially in efforts to promote their respective cultures.
"This is one of the initiatives under the Sabah Maju Jaya blueprint," he told reporters after inaugurating the Rumpun Bajau Sama Sabah Association (PRBSS) Cultural Centre at Kampung Lok Batik here today.
Also present were Agriculture and Food Industries Minister Datuk Seri Dr Ronald Kiandee and former Sabah chief minister Tan Sri Musa Aman.
Earlier in his speech, Hajiji, who is also PRBSS president, said the cultural centre would contribute to the pride and socio-cultural progress of the Bajau Sama ethnic group in the state.
The Sulaman state assemblyman said the centre was built over 1.42 hectares of land and the project was completed in July with an allocation of RM7.5 million.
He said Musa had approved the construction of the cultural centre during his tenure as chief minister, and the groundbreaking ceremony was held in 2017.
So far PRBSS has 17 branches, namely in Tuaran, Kudat, Kota Marudu, Pitas, Kota Belud, Tenghilan, Tamparuli, Kuala Menggatal, Kota Kinabalu, Petagas, Papar, Kuala Penyu, Pulau Banggi, Beluran, Sandakan, Tawau and Semporna.
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The California Citizens Redistricting Commission: Fair Maps, Voting Rights, and Diversity
The Schwarzenegger Institute is excited to announce the release of its newest policy report that closely examines the California Citizens Redistricting Commission. The first California Citizens Redistricting Commission drew the lines from 2012 to 2020. The second California Citizens Commission is nearing the end of its process of being selected. Eight commissioners were randomly chosen on July 2, and these 8 will pick the final 6 commissioners. The new Commission's first meeting is Tuesday, July 21, 2020.
Schwarzenegger Institute Academic Director Dr. Christian Grose partnered with Dr. Jason Casellas (University of Houston) and Dr. Michael Minta (University of Minnesota) to analyze the levels of diversity in the 2020 Redistricting Commission process; examine representation in the California Legislature and the congressional delegation both pre- and post-creation of the commission; and make several conclusions regarding how Redistricting Commissions can enhance racial and ethnic diversity. The report examines the Commission selection process so far, and finds that the diversity of the applicant pool increased in the selection of 60 finalists, but decreased when the state legislature struck names of applicants from the pool. The California Redistricting Commission has been praised as a model of redistricting in terms of creating fair maps that do not consider partisanship or incumbency protection. In addition to fair maps on these dimensions, the report also finds that the first California redistricting commission maps used from 2012 to 2020 did not simply result in fair maps by party, but it also led to levels of racial and ethnic diversity in the state legislature and Congress never seen in the history of California. Drawing maps by Commission led to greater diversity than maps drawn by the legislature in the past. Casellas, Minta, and Grose then used this research to make several policy recommendations on how the Commission can engage with communities of interest, promote diversity, and follow the guidelines set forth in state law so that Californians are included and represented in the redistricting process and future elections.
EXECUTIVE SUMMARY AND KEY FINDINGS FROM THE POLICY REPORT
• We examine racial and ethnic diversity in the California Citizens Redistricting Process.
• In 2020, from the completed application stage to the selection of 60 finalists for the commission, the Asian-American applicant proportion increased by 14.2 percentage points; and the Latino/a applicant proportion increased by 9.9 percentage points. Prior to this, though, there were lower proportions of Asian-American and Latino/a applicants relative to the California voting-eligible population and state population.
• California legislative leaders' ability to strike 24 of the 60 finalists led to a numerical decline in Latino/a finalists. Had the legislature not struck 7 of 14 Latino/a finalists, the random draw choosing the first eight commissioners would likely have resulted in at least 1, if not more, Latino/a commissioners among the first 8.
• 62.5% of the first eight chosen identify as people of color. However, no Latino/a Californians were chosen among the first eight commissioners. The new partially-formed commission has three African-American members, a historic high for a California redistricting commission; two Asian-American members; and three white members. There are four women and four men in the first eight. Two commissioners also identify as LGBTQ.
• The first eight commissioners are required by law to consider diversity imbalances in selecting the final six commissioners. The Commission will add 6 final members by August 15, and has an opportunity and is likely to appoint Latino/a commissioners to the final 14.
• The Voters First Act establishing the Commission requires diversity as a consideration in drawing the maps. We analyze the California state legislature and congressional delegation under the commission-drawn map used from 2012 to 2020. We also evaluate the diversity of legislators elected under the legislative-drawn map from a decade prior. The commission-drawn map had greater racial and ethnic diversity among legislators.
• The Commission map doubled the percentage of Latino/a and Asian-American members of the U.S. House delegation from California over the last decade's legislative-drawn map.
• The Commission state legislative maps increased the percentage of Latino/a, African-American, Asian-American state legislators over the last decade's legislative-drawn map.
1. Choose the next 6 commissioners carefully, and address demographic imbalances, including the absence of Latino/a commissioners. In particular, we strongly recommend appointing multiple Latino/a commissioners.
2. Greater transparency in the legislative striking of applicants is needed and encouraged. Or consider removing the legislative strikes provision from the process in subsequent commission appointments.
3. The selection of Redistricting Commissioners could be block randomized by the racial and ethnic population as well as block randomized by party.
4. Redistricting Commissions must carefully evaluate voting rights, communities of interest, and the ability to elect candidates of choice in drawing legislative lines for 2022.
5. The Commission must seek public comment and engage in outreach.
6. The state must encourage a greater diversity of applications when hiring consultants responsible for generating enthusiasm among the state's populace to apply to the commission.
7. Use traditional redistricting principles such as drawing lines around communities of interest


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Accenture Tied Up in $50M Ransom Lockbit 2.0 Attack
Global consulting firm Accenture has been the target of ransomware group Lockbit, with the gang reportedly taking encrypted data from the company.
Lockbit says it will publish the data if Accenture does not pay the ransom, according to screenshots of the ransomware group's website. Infosecurity has asked Accenture for a comment on the ransomware attack.
In a statement provided to CNN, an Accenture spokesperson told the international outlet., "Through our security controls and protocols, we identified irregular activity in one of our environments. We immediately contained the matter and isolated the affected servers."
This data breach comes after the Australian Cyber Security Centre (ACSC) alerted organizations in the country that cybercriminals were frequently using Lockbit 2.0 ransomware. "The ACSC has received reporting from several Australian organizations that have been impacted by LockBit 2.0 ransomware," explains the alert. "This activity has occurred across multiple industry sectors.
"Victims have received demands for ransom payments. In addition to data encryption, victims have received threats that data stolen during the incidents will be published."
What is Lockbit 2.0?
Lockbit 2.0 was rolled out earlier this month — the latest version of the ransomware — and implements lots of additional features.
"With the recent international efforts on fighting ransomware, those gangs are finding it difficult to advertise their malware in hacking forums," explains Felipe Duarte, security researcher, Appgate. "A few posts from this new version of LockBit were spotted on a few forums frequented by cybercrime gangs, but they were quickly removed. This version is currently advertised on a new version of their website.
"Our team got access to LockBit's deep-web site, where the ad is published along with data from victims that refused to pay the ransom," continues Duarte. "Among the advertised capabilities is a new dangerous feature to encrypt entire Windows domains through group policies.
"After infecting a domain controller, the malware creates new group policies and pushes them to every device connected on the network. Those policies disable antivirus protections and execute the ransomware. Additionally, LockBit seems to have copied a feature from Egregor ransomware that, after a successful infection, sends to all connected printers a command to repeatedly print the ransom note."
Appgate explains that the new version of Lockbit adds a new strategy to acquire affiliates — after encrypting a device, it sets the wallpaper to a ransom note and claims responsibility for the attack, and points to a more detailed one note .txt file.
"Now the set wallpaper also contains a recruitment ad, promising millions of dollars to employees that provides them access to the company systems so they can launch a ransomware attack," the security researcher explains. "According to the ad, the access can be a valid credential or even executing a threat attached in an email.
"This strategy may seem unusual at first, but it's somewhat common for companies to get breached by employees. For example, in 2020, a Russian citizen living in the U.S. was arrested after offering $1 million to a Tesla employee to deploy ransomware in Tesla's internal network."
What is Accenture's response?
At the time of reporting, Accenture had not confirmed the details of the ransomware attack to Infosecurity. However, multiple news sources appear to show Accenture giving little weight to the attack, with the company saying that it has had "no impact" on the business.
According to ZDNet, the consultancy firm provided a statement that says, "There was no impact on Accenture's operations or on our clients' systems."
However, the outlet also reports that cybercrime intelligence firm Hudson Rock says that 2,500 computers of employees and partners were compromised in the ransomware attack. Another firm, Cyble, claims to have seen a ransom demand of $50 million for six terabytes (TB) of stolen data.
At the time of reporting, Accenture had not confirmed the details of the ransomware attack to Infosecurity. When asked to provide further details, a spokesperson told Infosecurity: "We aren't providing any more comment other than the statement."
However, from what we do know from multiple news sources, Accenture is downplaying the attack, saying it has had "no impact" on the business.
According to ZDNet, the consultancy firm provided a statement which says: "There was no impact on Accenture's operations or on our clients' systems."
However, the outlet also reports that cybercrime intelligence firm Hudson Rock says that 2,500 computers of employees and partners were compromised in the ransomware attack. Another firm, Cyble, claims to have seen a ransom demand of $50 million for 6 terabytes (TB) of stolen data.
NCSC Launches Microsoft Office 365 Button to Report Business Email Spam
Attackers Increasingly Turning to DDoS as a Ransom Vector


This Antique Mirror Container with Hinged Lid is a playful juxtaposition between the the matte, rough oak and the shine of the oxidised mirror. The lid hinges open and has five compartments that are ideally sized for jewels, or special items.
Timeless and unique. A special gift to a loved one, or yourself.


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Marie Alizon (Rennes, 9 de maig de 1921 - Auschwitz, 4 de juny de 1943) va ser una militant bretona de la Resistència francesa.

Biografia
Filla d'hotelers, pren la direcció de l'empresa familiar quan la seva mare cau greument malalta. Maria i la seva germana Simone Alizon contactaren amb la xarxa Johnny a l'octubre de 1941. Aquesta xarxa operava a Gran Bretanya des de març de 1941 i s'ocupava principalment de vaixells de guerra alemanys estacionats a Brest, quan, com a resultat dels arrests, la xarxa hagué d'abandonar els seus punts d'emissió de Finisterre. Es va traslladar a Rennes i Marie Alizon i la seva germana Simone rebien la informació codificada que posteriorment transmetien a les estacions de ràdio que radiotelegrafiaven a Londres. Hi havia dos operadors de ràdio a l'hotel, on els membres de la xarxa rebien asil quan viatjaven a Rennes.

La Feldgendarmerie va arrestar Marie i Simone Alizon el 13 i 17 de març de 1942. Foren empresonades uns dies a Rennes, i d'allí foren transferides a la presó de La Santé a París, després a la centre de detenció de Fresnes i finalment, el 10 de novembre 1942 al Fort de Romainville. Cap al gener de 1943 s'assabenten de la mort de la seva mare, esdevinguda el 5 de juliol de 1942.

Ambdues són deportades al camp d'Auschwitz el 24 de gener de 1943 (amb el comboi dels 31.000). Marie va morir, esgotada, a causa d'una otitis sense tractat després d'haver estat transferida al revier el 4 de juny de 1943. Simone Alizon va sobreviure als camps, tot i conservar importants seqüeles. Es va casar amb un dels fundadors de la xarxa Johnny, Jean Le Roux.

Referències

Enllaços externs

 Mariette et Poupette en Résistance : les sœurs Simone et Marie Alizon, enenvor.fr
 Mariette et Poupette en Résistance : les sœurs Simone et Marie Alizon  a criminocorpus.hypotheses.org

Persones de Rennes
Membres francesos de la Resistència francesa
Morts a Polònia

redpajama_set_name: RedPajamaWikipedia


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Ashcroft's army
Justice Dept. fires up antipiracy ops
By Susan Crabtree
Susan Crabtree
Indie pics catch break with tax bill
Not kidding around
FCC won't block doc
WASHINGTON — Taking several pages from the country's wars on drugs and terrorism, the Justice Dept. is launching an initiative in its battle against criminal piracy in this country and abroad.
And if Attorney General John Ashcroft has his way, next year Congress will approve legislation that criminalizes the possession of counterfeit goods with the intention of selling or trafficking them and amend the copyright statute to make attempted piracy a crime whether or not an individual is successful.
During a visit to Los Angeles today, Ashcroft will unveil a landmark antipiracy initiative aimed at giving the federal government sweeping powers to crack down on organized crime rings as well as individuals who engage in widespread intellectual property theft.
Ashcroft will join U.S. Attorney for Los Angeles Debra Yang to announce the adoption of 55 pages of recommendations by the DOJ's Task Force on Intellectual Property.
Among a dozen changes to current criminal enforcement of intellectual property law, the initiative will add five antipiracy offices around the country, according to a copy of the task force report, which will be released to the public today.
Justice will add units in Nashville, one of the world's most important outposts in the recording industry, as well as D.C.; Orlando, Fla.; Pittsburgh; and Sacramento.
The offices, called Computer Hacking and Intellectual Property (or Chip) Units, will supplement the 13 existing U.S. Attorney's offices and some 60 prosecutors devoted to fighting piracy.
Effort will also beef up existing Chip units located in Los Angeles and San Jose, two hotbeds of intellectual property theft, with several new prosecutors, and it will designate a Chip coordinator in every federal prosecutor's office in the nation.
To support the aggressive crackdown, Ashcroft is calling on Congress to approve broad new powers for law enforcement to go after pirates. Many of the new powers are familiar, plucked from the federal government's unique authority to pursue drug traffickers, and to a lesser extent, from the controversial Patriot Act, which gave law enforcement more authority to combat terrorism.
According to the report, other legislative goals include granting fresh authority to use wiretaps to investigate intellectual property crimes; criminalizing the importation and exportation of counterfeit goods and unauthorized copies of copyrighted works; assigning a designated retail value to pre-release copyrighted works; and permitting the extradition of individuals accused of intellectual property crimes as long as they are violations in the U.S. as well as the other nation involved.
"The attorney general recognizes that intellectual property theft endangers our country's economic and national security, and that's why he's so supportive of this effort," said David Israelite, Ashcroft's deputy chief of staff, who spearheaded the task force.
After an 11 a.m. press conference with the U.S. Attorney's Office in Los Angeles, Ashcroft will meet privately with studio execs and Motion Picture Assn. of America topper Dan Glickman to discuss the initiative.
Last week Israelite previewed the announcement during a conference call with Recording Industry Assn. of America chieftain Mitch Bainwol and several music label execs.
The relationship between the Republicans in Washington (including the Bush administration) and Hollywood has been chilly at best. Just last week House Republicans dealt the movie biz a serious blow by refusing to include a tax cut for the industry — potentially worth up to $5 billion over the next decade — in a massive corporate tax bill.
Political insiders interpreted the legislative defeat as retribution for the Motion Picture Assn. of America's hiring of Dan Glickman, a Democrat, to replace retiring Jack Valenti.
No such rift has occurred with the music industry. Mitch Bainwol was a savvy GOP political operative before the music labels tapped him to head the RIAA.
"The recording industry has been a priority in this effort because we believe they've been hit hardest by intellectual property theft and we think they've done the most to help themselves," Israelite added. "We have a very good working relationship with the leadership of the recording industry with Mitch Bainwol at the helm."
A felony to swap a lot
Justice's aggressive stance, however, is not designed to help the industry pursue civil lawsuits against thousands of individuals including college students, although the department reserves the right to pursue criminal action against them. The task force supports legislation pending in Congress right now that would make it a felony to swap 1,000 songs online without copyright owners' permission.
"I'm not going to say we're never going to go after individuals and college kids," Israelite said. "Everyone should know that the federal government is getting more aggressive against the theft of intellectual property."
Civil liberty orgs didn't completely condemn the effort, although some expressed serious concerns about how the government will wield its antipiracy powers.
"I don't think the DOJ is going to start throwing college kids (who illegally swap music online) in prison, but it gives DOJ leverage over millions of Americans," said Fred von Lohmann, an attorney for the Electronic Frontier Foundation, a nonprofit cyber-liberties org. "As a group devoted to civil liberties, we're always concerned about federal investigators' ability to lean on you."
Intellectual Property Enforcement Coordinator


The Kuwait Investment Authority (KIA), the oil-rich nation's sovereign wealth fund, is planning to triple its investment in Japan to $48 billion, highlighting a global investment shift away from U.S. assets.
That investment boost would follow Japan's recent agreement with Kuwait to reduce – or end – double taxation on interest, dividends, and capital gains. Japan has similar agreements with about 60 countries, but the deal with Kuwait is the Asian nation's first with a Middle-Eastern state, according to the Financial Times.
KIA is currently invested in Japanese stocks and bonds, Shamali said, but is looking to expand into the nation's real estate sector – and may also delve deeper into Japan's stock market.
As Money Morning has been reporting for some time, Japan is becoming an increasingly alluring investment alternative to the United States – especially because of its growing involvement with China – a reality that global investors are beginning to grasp themselves. But Japan's growing profit potential isn't the only reason the KIA is engineering this shift.
An increased level of investment in Japan is part of Kuwait's plan to diversify away from American assets. The country removed its currency peg to the U.S. dollar in May 2007, and the KIA has been dissatisfied by its investments in Citigroup Inc. (C) and Merrill Lynch & Co. Inc. (MER). Over the past two years, the KIA has raised the portion of money allocated to Asian investments from 10% to 20%. The fund controlled approximately $270 billion at the end of March.
Kuwait is just one of many Middle Eastern states to benefit from the tidal swell of capital that's been washed through the region, following the pull of record oil prices. And yet, increasingly cognizant that their oil money will dry up one day, Middle East nations are diversifying their investments for that future time. That's one reason Dubai is repositioning itself as a gateway point for global trade and tourism, and is constructing the world's largest airport, a project that's creating profit plays for investors throughout the world. This realistic view of the future is also the reason that Gulf Arab states and companies spent about $60 billion on foreign assets in 2007, almost double the previous two years combined, according to Reuters.
However, foreign investment that has traditionally been earmarked for the United States is now pouring into developing markets with more growth potential.
Last month, the Financial Times reported that a large, unnamed Gulf fund had cut its dollar-denominated holdings from more than 80% a year ago to less than 60%.
Earlier this year, Qatar Investment Authority bought a 27% stake in Dragon Capital, a Vietnamese property fund. And in February, it bought a 15% stake in an Indian office development being built at the Bandra Kurla complex in Mumbai.
The fund has $60 billion in assets and more emerging market real estate investments are in the works.
"We are focusing on prime cities in India, China, Singapore, Korea, Vietnam and Malaysia, cities around the world where there is strong [gross domestic product] growth and fundamental unmet demand for high quality real estate," Navid Chamdia, head of real estate at Qatar Investment, told Bloomberg at a sovereign-wealth funds conference in Abu Dhabi. "About 40% of our real-estate investments will be in Asia."
Even China – which has strong investment ties with the United States – is diversifying away from the U.S. market. For instance, China's State Administration of Foreign Exchange (SAFE) has been actively seeking deals with private equity firms in Europe as part of a specific strategy to reduce its dollar-denominated holdings. A shift in policy at China's SAFE is particularly significant because it holds the vast majority of China's $1.68 trillion of foreign currency reserves in dollar-denominated assets.
The Lost Decade: How the U.S. Financial Crisis Resembles Japan's Ten Years of Misery – And How to Play it for Profit.
Three Ways to Profit From the Biggest Airport on Earth.
Kuwait's KIA to triple Japan investments -KUNA.


text:
Ultra high performance liquid chromatography- ultraviolet-electrospray ionization-micrOTOF-Q II analysis of flavonoid fractions from Jatropha tanjorensis
Arun Kallur Purushothaman, Brindha Pemiah
Centre for Advanced Research in Indian System of Medicine, SASTRA University, Thanjavur, Tamil Nadu, India
Date of Submission 08-Jan-2014
Date of Acceptance 27-Mar-2014
Arun Kallur Purushothaman
Centre for Advanced Research in Indian System of Medicine, SASTRA University, Thanjavur 613 401, Tamil Nadu
Source of Support: Financial support from the DST (VI.D and P/267/08.09/ TDT), Government of India for the purchase of LC.MSMS instrument is gratefully acknowledged,, Conflict of Interest: None
Background: Jatropha tanjorensis (Euphorbiaceae) an exotic traditional plant unique to Thanjavur district of Southern India also commonly called as Catholic vegetable. It has been used traditionally in decoctions for treating various ailments and as a health tonic. Objective: The objective of the present work is to study a comprehensive characterization of methanolic extract fractions using ultra high performance liquid chromatography (UHPLC)+-electrospray ionization (ESI)-micrOTOF-Q II and correlate their bioactivities. Materials and Methods: Phytoconstituents from J. tanjorensis leaves were extracted with methanol (MeOH) followed by successive chromatography using linear gradient polar solvents system. All fractions obtained were evaluated for their chemical potential using micrOTOF-Q II techniques and identified key molecules were determined for their anticancer and anti-oxidant potential using in vitro methods. Results: Successive column chromatography of the MeOH residue yielded six fractions. Compounds such as such as C-glycosylflavones (mono-C-, di-C-), O, C-diglycosylflavones and aglycones were identified for the first time in this plant using UHPLC-ultraviolet-micrOTOF-Q II ESI and a correlation with their anticancer using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide assay on Ehrlich ascites cells (EAC) and antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl and lipid peroxidation were studied; fraction D extract exhibited the strongest activity against cancer cell. Conclusions: LC-mass spectrometry has been successfully applied for a quick separation and identification of the major phytoconstituents. All fractions have shown potent antioxidative activity as compared to standard antioxidant 3,5-di-tert-butyl-4-hydroxytoluene. EAC cell-based cytotoxicity assay also revealed encouraging results. The antioxidant and anticancer activity determined in the present work can be attributed to the presence of flavonoids and flavone glycosides. Present work provides the first scientific report on phytoconstituents of J. tanjorensis and its ethnopharmacological significance.
Keywords: Antioxidant, Ehrlich ascites cells, Euphorbiaceae, flavonoids glycosides, Jatropha tanjorensis, liquid chromatography-mass spectrometry
Purushothaman AK, Pemiah B. Ultra high performance liquid chromatography- ultraviolet-electrospray ionization-micrOTOF-Q II analysis of flavonoid fractions from Jatropha tanjorensis. Phcog Mag 2014;10, Suppl S3:472-9
Purushothaman AK, Pemiah B. Ultra high performance liquid chromatography- ultraviolet-electrospray ionization-micrOTOF-Q II analysis of flavonoid fractions from Jatropha tanjorensis. Phcog Mag [serial online] 2014 [cited 2022 Jan 20];10, Suppl S3:472-9. Available from: http://www.phcog.com/text.asp?2014/10/39/472/139776
Jatropha tanjorensis Ellis and Saroja is an exotic plant in Africa, America and Asia (Southern India) and has been used in traditional medicine since long time. J. tanjorensis is an herbaceous plant belonging to the family Euphorbiaceae and commonly called catholic vegetable, Iyana ipaja, lapalapa. Ethnophamacologically J. tanjorensis (Church grass) leaves have been used since ancient. [1]
Plant leaves were initially and popularly consumed in Nigeria as soup and as a tonic with the claim that it increases blood volume. The leaves are also employed traditionally in the treatment of anemia (as a hematinic agent), diabetes, renal problems, cardiovascular diseases, hypertension and inflammation. [2] J. tanjorensis leaves are considered to possess antimicrobial and antiplasmodial properties. [3]
Recent research have proven scientifically its antidiabetic, [4] antiinflammatory, antimicrobial and antioxidant potentials. [5],[6] Presences of flavonoids in the selected drug source are of special interest due to their antioxidative properties. [7]
Reactive oxygen species have been implicated in the pathogenesis of many diseases, including liver toxicity, cancer, mutagenesis, etc. [8] Although many synthetic antioxidants are being currently used, there is a growing evidence of consumer's preference for natural antioxidants because of their lower toxicity. J. tanjorensis ethanolic extract has already been evaluated scientifically for its free radical scavenging activity. [6]
However, until now, there are no scientific studies on the phytomolecules identified and supporting the traditional use of this plant and thus, the aim of the present work was to develop a method for the identification of major phytoconstituents in the methanolic extract fractions of J. tanjorensis and to determine the most active antioxidant and anticancer fraction. The methanolic extract of J. tanjorensis was investigated chemically using reverse phase liquid chromatography (LC) coupled to electrospray ionization tandem mass spectrometer (LC/ESI/MSn).
Following reagents were purchased from Merck (KGaA, Darmstadt, Germany) and used in the present study: HPLC-grade acetonitrile, methanol (MeOH), 3,5-di-tert-butyl-4-hydroxytoluene (BHT), 2,2-diphenyl-1-picrylhydrazyl (DPPH), silica gel 100-200 Mesh (for column chromatography). 2-thiobarbituric acid (TBA) was obtained from Fluka Chemie GmbH (Buchs, Switzerland). All chemicals were reagent grade, unless otherwise stated.
Jatropha tanjorensis (Euphorbiaceae) fresh green leaves samples were collected in mid July 2012 from in and around SASTRA University campus, Thanjavur, Tamil Nadu, India. [5] Herbarium voucher specimens were prepared, identified with the deposited specimen at the Raphinet Herbarium (RHT 1291) St. Joseph's College, Tiruchirapalli, Tamil Nadu, India.
Shade dried and powdered plant material was depigmented using petroleum ether for 48 h and after vacuum-drying, extracted for 72 h with eight-fold amount of MeOH. Both extractions were carried out at room temperature. The process yielded 14% of raw extract on dry weight basis. Depigmented residue was fractionated using silica 100-200 mesh column by stepwise increasing polarity of the eluent to give six fractions, labeled A to F. For LC-mass spectrometry/mass spectrometry (LC-MS/MS) analysis and bioactivity assays, all fractions were dissolved in MeOH.
Liquid chromatography-mass spectrometry analysis
Chemical composition of each fraction was determined by ultra-high performance LC ([UHPLC] + focused) with mass selective detection, using Ultimate 3000 series LC (Dionex, USA) coupled with ESI tandem mass spectrometer (micrOTOF-Q II) (Bruker, Germany). Components were separated using reverse-phase Acclaim 120, reverse phase (RP)-C18 120 Ε, 2.1 × 150 mm, 3.0 μm column (Dionex, USA), held at 50°C. Mobile phase consisting of MeOH (A) and 1% aqueous formic acid v/v (B), was used with a discontinuous gradient; 0 min 95% B, to 80% B in 5 min, to 70% B in the next 5 min, at 15 th min B reaches 65%, next 5 min to reach 40% B, 2.5 min to reach 0% B, next 2.5 min to reach 95% B until the run ends, with a flow rate of 0.2 ml/min. Chromatographic profiles were acquired in the wavelength at 335 nm. Injection volume was 50 μL. Eluted components were ionized by electrospray ion source (ESI), using N 2 for nebulization (pressure of 34.8 psi) and drying (flow of 7 L/min, temperature of 300°C). Set capillary voltage was 2600 V, end plate offset −500°V, collision cell RF 350.0 Vpp, energy transfer time of 80.0 μs, pre pulse storage of 10.0 μs. Data were acquired in MS/MS (auto) scanning mode. To increase the sensitivity, lower the noise, and simplify the spectra, negative ionization was used. Generated (M-H)− ions were analyzed using auto-MSn scan mode, in m/z range 50-2500 m/z.
2,2-diphenyl-1-picrylhydrazyl free radical inhibition assay
Selected concentrations (10, 100, 250, 500, and 1000 μg/mL) of J. tanjorensis fractions (10 μL) were mixed with 190 μL of MeOH and 100 μL of methanolic solution containing DPPH radicals (67.2 μmol/L). [9] Absorption at 517 nm was measured using NanoDrop 2000 series spectrophotometer (Thermo Scientific, Wilmington, DE, USA) after 60 min of incubation at room temperature. The extract concentration in the reaction mixture, resulting in 50% inhibition of DPPH radicals (IC 50 ), was calculated.
Lipid peroxidation inhibition assay
As a substrate for lipid peroxidation, freshly collected red blood cells (RBCs) were used and were resuspended to make 1% solution in phosphate buffer (37°C, pH 7.2). Selected concentrations (10, 100, 250, 500, 1000 μg/mL) of J. tanjorensis fractions (10 μL), each in triplicate, were mixed with 20 μL of 1.875 mmol/L ferrous sulfate and 20 μL of ascorbate (15.4 μg/mL). The control and corrections were also made as previously defined. All probes were incubated at 37°C for 1 h, after which 200 μL of 0.1 mol/L ethylenediaminetetraacetic acid was added to bind the Fe 2+ , thus stopping the reaction. TBA reagent (2 mL) was added, and the mixture was heated in boiling water bath for 15 min to form a stable, colored derivative with malondialdehyde (MDA). [10] After that, probes were centrifuged for 15 min at 3700 rpm and the absorbance was measured at 517 nm using NanoDrop 2000 series spectrophotometer (Thermo Scientific, USA). The values of IC 50 were calculated using GraphPad Software, Inc. CA, USA.
Anticancer assay
Ehrlich ascites cells (EAC) were treated with various concentrations of each fraction for 48 h under 37°C and 5% CO 2 in CO 2 incubator. 3- [4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay was performed in accordance with standard textual method. [11] After treating cells with different concentration of each fraction, absorbance was read out at 590 nm using Epoch microplate spectrophotometer (BioTek Instruments, Inc., VT, USA).
Data of the antioxidant and anticancer assays are expressed as the means ± standard deviation of three independent measurements. Statistical analysis of the data was acquired by Graphpad software package.
This study clearly demonstrated that J. tanjorensis extracts contain several classes of plant flavonoids with anticancer and antioxidant potentials. Mostly flavonoid glycosides and aglycones, as well as biflavonoids were identified in the MeOH extract. Although several publications were focusing on this topic, [12] there is still a lack of convincing evidence to determine, which flavonoid class is mostly responsible for the antioxidant and anticancer activity in the plant drug sources. Hence, in the present work attempts were made to detect flavonoids belonging to various class and their anticancer and antioxidant potentials were evaluated.
Crude extract fractionation
Crude methanolic extract (5 g) chromatographed over silica gel 100-200 mesh column and partitioned successively in a linear gradient to give six fractions, A (100% chloroform, 210 mg), B (100% ethyl acetate (EtOAc), 490 mg), C (75% EtOAc: 25% MeOH, 860 mg), D (50% EtOAc: 50% MeOH, 1.35 g), E (25% EtOAc: 75% MeOH, 1.0 g) and F (100% MeOH, 850 mg) as shown in [Figure 1]. All these fractions were stored at 4°C in dark condition until use.
Figure 1: Flow chart of various solvent used and yield of Jatropha tanjorensis leaves methanolic extract J fraction
Liquid chromotography-mass spectrometry analysis
Interesting results were obtained from the LC-MS/MS analysis of J. tanjorensis methanolic extract fractions. By UHPLC, a chromatographic method was successfully developed using Acclaim 120, C18 reverse-phase column from Dionex with ultraviolet detection at 335 nm that could resolve ~ 15 peaks from each fraction [Figure 2]. When this separation was coupled with the ESI/MS/MS mass spectrometry, the Total Ion Chromatograph presented in [Figure 3] was obtained. The collected data for the LC/ESI/MS/MS was analyzed by averaging followed by extracted ion analysis using the Hystar DataAnalysis program (Bruker Daltonics, Germany). Averaging and autoMSn options revealed approximately 200 ion signatures in the TIC for each methanolic fraction of J. tanjorensis leaves.
Figure 2: Ultra high performance liquid chromatography + ultraviolet chromatogram of each fraction of Jatropha tanjorensis leaves methanolic extract
Figure 3: Liquid chromatography-mass spectrometry/mass spectrometry chromatograms (total ion chromatograms [TIC]) of Jatropha tanjorensis methanolic extract fractions
Present evaluation of the ESI data yielded about ~100 completely unique ion signatures in the analysis of the J. tanjorensis. micrOTOF-Q II analysis was able to identify ~20 constituents by mass spectral matching and several of these assignments were further supported by comparing these data with previously published data of the constituents [Table 1].
Table 1: ESI-MS and ESI-MS/MS product ions of fractions from Jatropha tanjorensis leaves methanolic extract
Bioactivity assays
02,2-diphenyl-1-picrylhydrazyl free radical scavenging activity varied widely from very high to moderate. All samples possessed ability to scavenge DPPH radicals, where most of them had IC 50 values higher or closer to that with synthetic antioxidant BHT [Figure 4]. Inhibition of lipid peroxidation (LPO) by extract fractions was also demonstrated, with a low IC 50 as compared to the synthetic antioxidant BHT. All fractions were able to inhibit LPO dose-dependently, as efficient as synthetic antioxidants BHT. Results are presented in [Figure 5].
Figure 4: 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay result of each fraction from Jatropha tanjorensis leaves methanolic extract
Figure 5: Lipid peroxidation inhibition assay result of each fraction from Jatropha tanjorensis leaves methanolic extract
Anticancer activity
Each fraction showed almost similar results. They revealed moderate to high activity. EAC cells when treated with different concentration of each collected methanolic extract fraction showed contrasting results from that of antioxidant findings. Comparatively fraction D and fraction C showed the highest anticancer activity. Results are presented in [Table 2].
Table 2: Cytotoxicity assay performed on each fraction from Jatropha tanjorensis leaves methanolic extract
The polar constituents are of interest since most of the traditional preparations are only aqueous extractions. RP-UHPLC-/ESI/MS/MS works well for polar molecules and also provide the rapid assessment of plant extracts for the presence of medicinally active compounds with a minimum of prepurification. In LC/ESI/MS/MS the effluent from an UHPLC + is introduced into an ESI source coupled with dual quadrupole and TOF giving typical and well-understood ESI Spectra. The advantage to acquire ESI fragmentation data from a LC separation lies within the subsequent ability to use existing deconvolution and search programs to match results with well-established and commercially available ESI mass spectral databases. Extensive research is needed to develop or upgrade the available MS/MS libraries to prevent the difference in fragmentation patterns among ESI instruments; this would make the identification of the components in a complex mixture very easy.
All compounds that were identified are novel components of the selected plant leaves [Figure S1]. Major identified constituents are flavonoids and its derivatives with different degree of glycosides [Table 1].
In the present work, fractions containing flavonoids were detected in the MeOH extract of J. tanjorensis along with their structural pattern. These structures provided supporting evidences for their free radical scavenging, antioxidant, and anticancer properties.
All fractions were subjected to the antioxidant activity assays. Since, it is now recognized that there is no single confirmatory test to evaluate antioxidant activity of the compounds with wide spectra of structures, modes of action, and physical and chemical properties, [13] two assays were employed as a part of the present investigation.
2,2-diphenyl-1-picrylhydrazyl is a stable radical and is often used in assessing antioxidant activity. The free radical DPPH possesses a characteristic absorption at 517 nm (purple in color), which decreases significantly when exposed to radical-scavengers (due to hydrogen atom transfer from antioxidant to DPPH). A lower absorbance at 517 nm indicates a higher radical-scavenging activity of fraction. [14] In this assay, the ability of the methanolic extract fractions of J. tanjorensis leaves acted as donors of hydrogen atoms or electrons in the transformation of DPPH radical into its reduced form DPPH-H was investigated.
The activity observed is in a very good correlation with its chemical composition, where the most active fractions contain flavonoid glycosides and anthocyanins (Frc A, B, C, and F) and comparatively lesser in aglycones containing fractions (Frc D and Frc E). It is notable that mostly flavonoid glycosides (with apigenin, luteolin, delphinidin, petunidin and isorhamnetin sugars) seem to contribute significantly to radical-scavenging activity (showed a low IC 50 ) [Figure 4].
One of the main detrimental effects of reactive radical species (especially OH) is LPO that is, oxidative degradation of lipids, leading to biological membrane damage and possibly to cell death or the formation of mutagenic/carcinogenic products. The best known LP product is MDA and it has been used most widely as a biomarker in various studies associated with lipid peroxidation. The determination of MDA may be problematic because of its high reactivity and water solubility, and it is therefore necessary to generate stable derivatives. One of the most commonly used is TBA adduct, which can be determined spectrophotometrically. In the present work, freshly collected 1% RBCs solution was used as a substrate for LP due to its high content of polyunsaturated fatty acids. LP of polyunsaturated fatty acids was triggered by Fe 2 + and ascorbate (which, through fenton reaction, generate OH·radicals). [15]
All the fractions were in correlation with the test results with chemical composition of fractions. It is known that flavonoids, either that with catechol-like substitution on B ring or with 4-oxo-3-hydroxy or 4-oxo-5-xydroxy substitution, are efficient in inhibiting LP, both through radical scavenging and through chelation of iron ions.
All fractions were subjected to the cytotoxicity activity against EAC using MTT reagent. Results obtained clearly proves that aglycones and anthocyanidins (kaempferol, chrysoeriol, baicalein, 3',7-dimethoxy-3-hydroxyflavone and peonidin) has potent anticancer property than its related flavonoid sugars with various degree of C and O linkages.
It was also noted that fractions containing mono-glycoside flavonoids (Frc D, E and F) and with more di-C-glycosides (Frc C) has shown better cytotoxicity effect than the fractions containing di-glycosides (C-O and O-O linkages). Although Fraction B do contain di-glycosides, but the linkage is through C-O and O-O di-glycosidic, which may be the reason of decreasing the cytotoxic potency. IC 50 values of each fraction were calculated using GraphPad Software, Inc. CA, USA.
Present results demonstrated that methanolic fractions of J. tanjorensis leaves obtained by successive solid-liquid extractions with solvents of different polarities possess antioxidant and anticancer activities. In the present work, six fractions of J. tanjorensis obtained and main constituents of each fraction were identified and correlated with the bioactivity obtained. UHPLC-ESI-Q-TOF technique has been successfully applied for a quick separation and identification of the major phytoconstituents. The present work provides the first report on the mentioned phytomolecules from J. tanjorensis. The antioxidant activity of flavonoid fractions has been assessed by scavenging DPPH free radical and LPO using freshly collected RBC as a substrate, where possible, synthetic antioxidants BHT was also used as a standard. An attempt was made to correlate the chemical composition of the extracts with its antioxidant and anticancer activity and to determine, which groups of biomolecules possess most potent activity. All fractions have shown a very high antioxidative activity as compared to standard antioxidant (BHT). Significant antioxidant activity was determined for most of the fractions by the DPPH assay (lowest IC 50 of 74.04 μg/ml) and LPO (174.2 μg/ml). EAC cell based cytotoxicity assay also revealed encouraging results. Methanolic extract fractions of J. tanjorensis have shown potent anticancer property as proved by MTT bioassay (highest cytotoxicity with IC 50 of 8.03 μg/ml). The antioxidant and anticancer activity determined in the present work can be attributed to the presence of flavonoids and flavones glycosides. For the pharmaceutical products production, the preparation of the enriched extracts may be of interest. In this paper, it has been demonstrated that it is possible to obtain extracts with high levels of flavonoids by using a relatively simple procedure, which appears to be a suitable candidate to develop a new therapeutic agent against cancer.
The authors would like to thank Vice-Chancellor, SASTRA University for his constant encouragement. Financial support from the DST (VI-D and P/267/08-09/TDT), Government of India for the purchase of LC-MS/MS instrument is gratefully acknowledged.
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[Table 1], [Table 2]
1 Direct Molecular Fishing of Zinc-Dependent Protein Partners of Amyloid-beta 1–16 with the Taiwan (D7H) Mutation and Phosphorylated Ser8 Residue
P. V. Ershov, Yu. V. Mezentsev, E. O. Yablokov, L. A. Kaluzgskiy, A. S. Ivanov, N. V. Gnuchev, V. A. Mitkevich, A. A. Makarov, S. A. Kozin
Molecular Biology. 2020; 54(6): 904
Purushothaman AK
Pemiah B
Ehrlich ascites cells
flavonoids glycosides
Jatropha tanjorensis
liquid chromatography-mass spectrometry


On a tree-lined street in a residential neighborhood, a Long Beach landmark has been reborn. One of three Southern California women's clubs built in 1924, the Long Beach building has been privately purchased and re imagined into one of Southern California's most beautiful historic venues.
With its decades-long legacy the venue has been officially designated as historic venue in Long Beach. The Ebell also has distinctive architectural features and is a prime example of the Spanish-Revival design favored during the 1920's. Featuring the characteristic red-tile roof and a soaring intricately sculpted portico makes a dramatic statement and beautiful backdrop for photographs. Rich details and a variety of textures allow you to experience intimacy and grandeur in one stunning venue, making your event possibilities limitless.
While the original structure has been carefully restored, the Ebell's 25,858 square feet of event space has been renovated by the experts responsible for creating the stunning Carondelet House in Los Angeles.
A light drenched, sky-lit, covered courtyard with coffered, hand-stenciled ceilings, exposed brick, detailed archways, ornate fountain and mosaic cement floor tiles is the first room to greet guests and provides one of many "wow" factors. A dozen crystal orb chandeliers hang like jewels from the ceiling and make the room truly opulent.
The fully furnished parlor room offers several exquisitely styled seating vignettes with vintage décor and tasteful artwork. Exposed white washed brick, tapestries and a handsome hearth in the room's center create a cozy, personal ambiance. During the cocktail hour, leave the room's French doors wide open to reveal the sparkling courtyard fountain in the background. A perfect setting for cocktails and hors d'oeuvres.
The stately ballroom has soaring 24 ft. hand-stenciled, beamed ceilings and dazzling crystal and iron chandeliers. High, detailed wainscoting, iron wall sconces, gleaming hardwood floors and a mirrored, floor-to-ceiling hand carved fireplace make this one of the most majestic rooms in Southern California.
My husband and I were married at the Ebell last month and were so delighted to have found the venue. It swept us away and could not have been more perfect. The team there was a pleasure to work with. It was very convenient having the catering in house. We had countless guests exclaim that it was the best food they had at a wedding.
Our wedding was beautiful! The Ebell team made our day beautiful and tied all of our needs into the design of our event. Cheers!
Staff was extremely friendly and responsive to my billions of questions. Absolutely stunning venue, I couldn't ask for a more spectacular backdrop for my wedding photos.
What a beautifully unique location for a reception. I love the "feel" of this place.
In 20 years of presiding over wedding ceremonies, we can certainly say that it is more than the beauty of a wedding venue that makes a wedding day dream. Rare is the wedding location that offers old world beauty, elegance, charm and class in companionship with an delightful event coordinating staff. The Ebell Club, a Long Beach historical treasure, restored in 2003 (by experts responsible for remodeling the Hotel Bel Air), brings 25, 858 square feet - from arched colonades to a double story courtyard to a tiled Spanish fountain - of premier wedding venue. From the grand to the cozy, the Ebell Club is a wedding venue of classic beauty, but also of competant, friendly, helpful and attentive event coordinating staff. The Clergy Network has presided over a number of wedding ceremonies at the Ebell Club, and as wedding professionals can happily recommend this impressive Californian wedding location. Don't select a wedding venue in Los Angeles county until you first visit this welcoming wedding venue to discuss your wedding event with their experienced wedding coordinating staff. For more information on our pleasant professional experiences with the Ebell Club and its event planning staff, feel free to ring us at 714 970 8839.


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New York City's nesting turtles and their eggs need help
NEW YORK (FOX 5 NEWS) - June to July is turtle nesting season. The little guys need some help from humans to make sure eggs have a chance to hatch, experts say. While this oppressive heat may be too much for people, diamondback terrapins tend to like it.
Dr. Russell Burke is a biologist who spends his summers at the Jamaica Bay Wildlife Refuge in Queens studying the turtle population. You can find the reptiles in the salt marshes but come June and July the females make their way to the fields to nest.
They dig the hole, lay the eggs, tamp the sand down on top it, scratch the sand back over the top so you can't see it and then they run away," he said, adding that terrapins are being killed faster than they're being replaced, especially this time of year when drivers aren't careful.
"I moved here 20 years ago and there used to be healthy populations along the southern end of the Meadowbrook and now those turtles are mostly gone," Burke said. "I almost never see turtles there anymore."
To help boost the population, he digs up terrapin eggs and studies their hatch rates in a controlled environment. It is uncommon for eggs to hatch on their own because they have so many predators. All of the eggs collected from the nests are brought to the lab. They incubate for 80 to 90 days and they're released once they hatch.
"Their sex determination is based on the temperature of the nest," said Kelly Hamilton of the state Department of Environmental Conservation. "If it's warmer temperatures, they tend to hatch females. And if the eggs are cooler temperatures they tend to hatch males."
The DEC said it is hard to control a turtle's instincts. One female Burke showed us is at least 80 years old and she isn't changing her ways now. What can we do to help? Watch where you're going on the roads.
"Every one of those turtles has lived a long life and we'd like them to continue to live a long life," Burke said.


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111721 Magee Prize Winners
Pitt Researchers Part of International Team Awarded $1 Million Magee Prize
Asher Jones
Manager, Science Writing
jonesag@upmc.edu
Amy Charley
charleya@upmc.edu
PITTSBURGH – Tonight at the Magee-Womens Summit, Magee-Womens Research Institute (MWRI) awarded the $1 million Magee Prize to an international team led by Pamela Moalli, M.D., Ph.D., director of urogynecology and pelvic reconstruction surgery at UPMC Magee-Womens Hospital and MWRI. The team is working to develop new biomaterials to repair tissue loss in women with compromised vaginal structure and function.
"We believe we are the right team to achieve the aims of the proposal, and we look forward to a productive collaboration in the future," said Moalli in accepting the award.
An increasing number of women are seeking vaginal reconstruction to repair tissue loss after surgery for pelvic cancers or following ovariectomy, chemotherapy and radiation, which can result in the vagina becoming contracted, thinned and painful. After noticing a limited range of biomaterials for these procedures, Moalli was inspired to develop better solutions.
She assembled a team that includes Kyle Orwig, Ph.D., MWRI and University of Pittsburgh School of Medicine, and Caroline Gargett, Ph.D., Monash University, Australia. Their project seeks to identify stem cell populations that restore vaginal structure and function and isolate the cellular ecosystems needed for stem cell survival, proliferation and engraftment. The researchers will use a novel bioassay to develop vaginal organoids from these stem cell populations.
"I am beyond excited about this study because it provides a viable solution to young girls and women in whom vaginal structure and function has been compromised. Stem cell technologies for use in tissue biofabrication is where the future of reconstructive surgery lies," Moalli said.
The Magee Prize, which is funded by the Richard King Mellon Foundation, is among the largest grants of its kind in women's health that is awarded by a non-government institution. To qualify for the prize, teams must include at least one MWRI researcher and at least one international collaborator.
The winner was chosen from three finalists and announced at tonight's Magee Prize Dinner.
PHOTO INFO: (click image for high-res version)
CREDIT: Magee-Womens Research Institute
CAPTION: The winning team of the 2021 Magee Prize.


Times tables and spellings to be learnt each week. The meaning of each word for the spellings should be learnt also, as the children will be asked to write some of them in sentences in the test. If you find the spellings or times tables for your group easy, learn the next groups words too!
Homework will usually be given out on a Tuesday and the tests will be on the following Tuesday.
Reading Accelerated Reader books in preparation for taking book quizzes, including filling in their homework diary. We expect children to read at least 4 times a week. Their diary should be filled in by a combination of themselves and a grown up each week (for example, twice by the child, twice by an adult).
Please find below the government expectations for spelling in Year 3 and 4. Any time that could be spent learning the spelling patterns and groups listed would be beneficial.
Pay special attention to the rules for adding suffixes.
If the last syllable of a word is stressed and ends with one consonant letter which has just one vowel letter before it, the final consonant letter is doubled before any ending beginning with a vowel letter is added. The consonant letter is not doubled if the syllable is unstressed.
These words should be learnt as needed.
Most prefixes are added to the beginning of root words without any changes in spelling, but see in– below.
Like un–, the prefixes dis– and mis– have negative meanings.
The prefix in– can mean both 'not' and 'in'/'into'. In the words given here it means 'not'.
Before a root word starting with l, in– becomes il.
Before a root word starting with m or p, in– becomes im–.
Before a root word starting with r, in– becomes ir–.
re– means 'again' or 'back'.
inter– means 'between' or 'among'.
auto– means 'self' or 'own'.
The suffix –ation is added to verbs to form nouns. The rules already learnt still apply.
The suffix –ly is added to an adjective to form an adverb. The rules already learnt still apply.
The suffix –ly starts with a consonant letter, so it is added straight on to most root words.
(1) If the root word ends in –y with a consonant letter before it, the y is changed to i, but only if the root word has more than one syllable.
(2) If the root word ends with –le, the –le is changed to –ly.
–ally is added rather than just –ly, except in the word publicly.
(4) The words truly, duly, wholly.
The ending sounding like /ʒə/ is always spelt –sure.
The ending sounding like /tʃə/ is often spelt –ture, but check that the word is not a root word ending in (t)ch with an er ending – e.g. teacher, catcher, richer, stretcher.
If the ending sounds like /ʒən/, it is spelt as –sion.
Sometimes the root word is obvious and the usual rules apply for adding suffixes beginning with vowel letters.
Sometimes there is no obvious root word.
–our is changed to –or before –ous is added.
A final 'e' of the root word must be kept if the /dʒ/ sound of 'g' is to be kept.
–ous ending, it is usually spelt as i, but a few words have e.
Strictly speaking, the suffixes are –ion and –ian. Clues about whether to put t, s, ss or c before these suffixes often come from the last letter or letters of the root word.
–tion is the most common spelling. It is used if the root word ends in t or te.
–ssion is used if the root word ends in ss or –mit.
–sion is used if the root word ends in d or se.
Exceptions: attend – attention, intend – intention.
–cian is used if the root word ends in c or cs.
In the Latin words from which these words come, the Romans probably pronounced the c and the k as two sounds rather than one – /s/ /k/.
–s, but is added if the plural does not end in –s (i.e. is an irregular plural – e.g. children's).
Teachers should continue to emphasise to pupils the relationships between sounds and letters, even when the relationships are unusual. Once root words are learnt in this way, longer words can be spelt correctly, if the rules and guidance for adding prefixes and suffixes are also known.
business: once busy is learnt, with due attention to the unusual spelling of the /i/ sound as 'u', business can then be spelt as busy + ness, with the y of busy changed to i according to the rule.
disappear: the root word appear contains sounds which can be spelt in more than one way so it needs to be learnt, but the prefix dis– is then simply added to appear.
bicycle is cycle (from the Greek for wheel) with bi– (meaning 'two') before it.
medicine is related to medical so the /s/ sound is spelt as c.
opposite is related to oppose, so the schwa sound in opposite is spelt as o.


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Mitch Reiner is a Partner, COO and Investment Advisor with Capital Investment Advisors (CIA). He has been a proud member of the CIA team and family since 2005. He identifies three core pillars that define his time and life: family, business and community.