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Military spouses ask Sen. Tim Kaine to help with childcare in Alexandria roundtable
James Cullum June 29, 2021 at 3:30pm
Virginia Senator Tim Kaine got an earful on military family needs at a roundtable he hosted Tuesday morning at the National Military Family Association in Alexandria.
Facing few childcare options, one military spouse had to take three years off of work as a physician's assistant to take care of her young children.
"I have three kids that will have to go to different (childcare) places," the woman said. "Because in this area it's really hard, at least in my experience, to find childcare from infant through the lower elementary ages. So, I'm going to be driving around or finding a nanny for my youngest, which is on the plus side of $20 an hour is what we're finding, which is cost prohibitive."
On-base childcare options are scarce, as an estimated 65% of U.S. military families are forced to pay for childcare out of their pockets.
Kaine wrote the Jobs and Childcare for Military Families Act, which was introduced into the Senate last month. He's trying to get the Act attached to the massive National Defense Authorization Act, which Congress will be considering later this summer. As active duty military spouses experience high rates of unemployment, Kaine said he at least hoped the pandemic has taught employers that their workers can largely work from home.
"if we can help families with children have more knowledge in their pocket, and we can fund more childcare — those would be two big things," Kaine said.
The Act would help military spouses get jobs with the expansion of the Work Opportunity Tax Credit, in addition to the creation of flexible spending accounts so that childcare expenses are paid with pre-tax dollars.
One Space Force officer living in Alexandria said that her civilian husband was kept from taking jobs that required travel, since getting childcare was too difficult.
"In the space force between 30 and 40% of our missions are in 24/7 facilities," the officer said. "There's an assumption that a spouse is always going to be there to pick up the slack."
Kaine, the former Virginia Governor and Mayor of Richmond, was a missionary in Honduras and never served in the military, although one of his sons is a U.S. Marine reservist. He is also a member of the Senate Armed Services Committee, as well as the Foreign Relations and Budget Committees.
"I'm sort of hoping that maybe a silver lining of the last year has been people realized, 'Wow, a lot of folks can do really great work, even if they're not in the same zip code as the office.' And I know it's been a challenge for military spouses, this move phenomenon — 'I'd rather not hire this person even though they may be the more qualified because they're probably gonna have to move somewhere.' Well, employers are much more comfortable now with realizing we have a whole lot of great employees who were doing their work for home for last year and they were being very productive."
federal government military Tim Kaine
Alexandria urges caution with upcoming hazardous heat conditionsAlexandria using Teen Wellness Center at T.C. Williams High School for COVID-19 testing and vaccine pilot


It comes with great pleasure to welcome a true techno legend to the Octopus family.
Mike Parker's experimental and ritualistic approach sets him apart from the rest and in a time of over-saturation he is still one of those few artists whose sound you can spot in a heartbeat. For 20 plus years, he has perfected a unique interpretation of techno, instantly recognisable to contemporary audiences, which has earned him a legendary global status inspiring the likes of Donato Dozzy and many of his peers for decades now.
From his humble beginnings to the present day Mike Parker has amassed an impressive list of credentials paving his own lane with a unique style that breathes innovation yet honours the true values of techno. And after 20 years in the game, Mike is still a dominant figure that continues to carve his own niche in the ever-expanding world of electronic music.
For all requests, please contact Dion here.


In April this year I was asked to design a wreath of sweet peas for wedding stationary. The beautiful wedding was a few weeks ago. I am happy to be able to share with you a little bit about the process and the final piece!


Surrender at 20: 10/28 PBE Update: Preseason changes removed, 2014 Ranked Reward Summoner Icons updated, and more!
10/28 PBE Update: Preseason changes removed, 2014 Ranked Reward Summoner Icons updated, and more!
The PBE has been updated! First up the massive amount of experimental preseason changes HAVE BEEN REMOVED, although the Summoner's Rift update is still up for testing. Other than that we have updates to the 2014 Ranked Reward summoner icons, tentative balance changes for Sion, and more!
The upcoming 2014 ranked season reward summoner icons have all been updated. Each icons have been brightened up a bit and the color of the numbers now matches the color of each rank. Remember that challenger has three icons because icons are distributed in that rank by top 10/50/200 solo player and top 3/15/50 teams.
For a comparison, check out the INITIAL version of the icons here. Remember that the season ends on November 11th!
Vintage Loading Screens have been added for both Grey Warwick and Medieval Twitch due to the upcoming changes to the Refer a friend system. Players who have earned these two reward skins PRIOR to the launch of the Refer-A-Friend changes will have this exclusive loading screen.
The experimental preseason changes have been removed from the PBE - This includes including the objective changes, tower changes, jungle itemization, new items, jungle, Scuttle Crab, summoner spell changes, base stat ^ regen changes for champions that were added in 10/9, readded in 10/24, then iterated on during the 10/27 update.
As Ypherion mentions in this post, they preseason changes will remain off the PBE until the end of this patch cycle as they will not be shipping to live in 4.19.
NOTE: To be absolutely clear, the new skins (Reaper Soraka and Victorious Morgana), new ward skins, champion specific balance changes, Singed model and texture updates, End of Game Gifting, new summoner icons, and all that other stuff is still up on the PBE. The Summoner's Rift update is also still up for testing on the PBE.
Going to be testing out an buffed W range for Soraka as well as a fixed travel time cast paradigm for Q (like Nami bubble instead of Twitch Cask).
The first version up today is probably a bit too fast, and I will probably be iterating through a number of values to find the one that feels juuuust right.
Anyway, would love feedback about how these changes feel and the playing-against feedback is especially vital. Leave any feedback you have here and I promise I'll be reading all of it ^_^"
Turns out these didn't make it into today's update!
"Well I'm bad and turns out these changes didn't make it in today. Should be in tomorrow though. This will at least give me time to fix up this missile speed so it's more consistent with the live version at long range."
The base stats changes (HP, Mana, MR, Damage, Armor, Regen) of all champions that are a part of the preseason changes have been reverted. Everyone is back to their live values.
Unspeakable Horror (E) reverted back to live; no longer lists the new passive effect of gaining boosted movement speed towards feared targets.
Health per level increased to 73 from 70.
Soul Furnace (W) permanent bonus health for killing a large monster and on enemy champion kills + assists increased to 10 from 8.


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Everyone Loves Guitar
Lenny Castro - TOTO - Everyone Loves Guitar
Craig Garber
Go behind the scenes and uncover the stories you'll never hear about in books and guitar magazines
We sit down and talk with interesting professional guitar players, and find out what makes them tick. Uncover the backstory behind your favorite guitar players, artists and sidemen. If you love guitar, success, life stories and meaningful life lessons, then stick around… you're in the right place.
Publié le vendredi 12 juillet 2019 à 06:00 par Craig Garber
One of the most recorded percussionists in pop history, Lenny's a member of TOTO and has played with Steve Lukather, Rolling Stones, Elton John, U2, Glen Frey, The Eagles, Dan Fogelberg, Fleetwood Mac, George Benson, Red Hot Chili Peppers, Tom Petty, Rod Stewart, Mars Volta, Los Lobotomys, Joe Bonamassa, Joe Cocker, hundreds of others, and has also worked on major motion pictures, commercials and animations
Lenny shares loads of great stories about playing at after hours clubs in Spanish Harlem - at age 14!... Getting discovered by Melissa Manchester in a retail drumming store, how TOTO built their song Africa using dozens of tape loops… dealing with an incredibly difficult personal tragedy, his favorite guitarists, the importance of keeping your eyes open and literally LOADS more cool stuff. Very positive vibe, tons of energy!
Subscribe https://www.everyonelovesguitar.com/subscribe/
Facebook: https://www.facebook.com/EveryoneLovesGuitar/
Instagram: https://www.instagram.com/everyonelovesguitar/
Twitter: https://twitter.com/ELovesGuitar
The Unheard Music
The ORIGINAL Alternative & Indie Rock
20th Century Alternative and Indie Rock on THE UNHEARD MUSIC. Join Kenny Arena as he revisits the origins of alternative, punk, new wave, post punk and indie underground from the 70's, 80's & 90's. Tuesday's 9:00pm & 12:00am EST & Saturday's at 10:00am EST on FlashbackAlternatives.com
Solar Radio Show – Radio Campus Tours – 99.5 FM
Actualités sociales, culturelles et universitaires locales, découvertes musicales, documentaires sonores et ateliers radio.
Ben's Country Music Show
Interviews and extra post-show content from Ben's Country Music Show!
Ben's Country Music show is broadcast on stations in the East Midlands of England. Ben has been presenting the show for some three years and in that time has interview a number of artists and musicians both in the UK and America. Here you can find full interviews from Ben's recent trip to Nashville, TN as well as additional post-show content that might have missed on air!
CHAPcast - A Guide to Music in Scotland
CHAPcast is a podcast about what's happening with…
CHAPcast is a podcast about what's happening with music in Scotland. Hosted by Ashley Park, the show includes interviews with bands, artists, label owners, venue owners, and gig promotors as well as music from different genres and parts of the country. Get in touch if you would like your music played on the show. CHAPcastshow@gmail.com
Hot Dub Time Machine: RADIO
Memories, music, moments in time
Australian DJ and music lover Hot Dub Time Machine delves into the personal histories of his favourite Australian musicians and personalities, taking audiences on an emotional journey back through each musician's life and career, accompanied by the music they loved.

redpajama_set_name: RedPajamaCommonCrawl


The Freshman Fellowship Program at Northern Michigan University provides academically talented students with an enriched educational experience. Some of the programmatic advantages include formal learning outcomes, while others are more personal, involving interactions with a faculty mentor, other freshman fellows, and advanced students and staff at the university. The program provides an opportunity to understand and practice scholarship, work with a university professor, interact with other students and enhance overall intellectual curiosity … all while earning a cash stipend.
The Freshman Fellowship Program consists of a monetary award of up to $1,000, paid per hour. Most fellows work 4 to 5 hours per week throughout the year with their faculty mentor. Fellows have been placed with mentors in a wide variety of academic fields, including biology, business, chemistry, criminal justice, economics, education, history, geography, nursing and psychology.
To learn more about what kinds of research happens at NMU, check out our faculty research interests directory.
The qualifications required to become a freshman fellow are a minimum high school grade point average of 3.5 and a minimum score of 24 on the ACT or 1160 on the SAT. Once accepted, all fellows are matched with a faculty mentor who shares the fellow's academic interests. The success of the program rests on the joint commitment of the fellow and mentor to engage in the pursuit of scholarship at NMU.


Seven new mission presidents and their wives have been called by the First Presidency. They will begin service about July 1.
Vladimir Jesus Campero, 65, and Elsa Cardozo Montero Campero, five children, Ukraine Donetsk Mission; Hamacas Ward, Santa Cruz Bolivia Equipetrol Stake. He serves as an Area Seventy in the South America Northwest Area and is a former stake president, counselor in a stake presidency, high councilor, bishop and counselor in a branch presidency. Self-employed, home construction. Born in Oruro, Bolivia, to Elias Manuel Campero Arteaga and Maria Concepcion Negrete Quiros.
Sister Campero serves as a stake Primary president and is a former counselor in a stake Primary presidency, stake family history center director and Relief Society president. Born in Tarija, Bolivia, to Armando Cardozo and Irene Montero.
Zahui Dominique Dekaye, 54, and Nathalie Brigitte S. Djedje Dekaye, two children, Ivory Coast Abidjan Mission; Cocody Ward, Cocody Cote d'Ivoire Stake. He serves as a stake president and is a former public affairs chairman, stake president, bishop, elders quorum president and counselor in a branch presidency. Associated director, MCR International. Born in Yazerme, Ivory Coast, to Maurice Gore and Yehiri Catherine Ouga Dekaye.
Sister Dekaye serves as a counselor to a ward director of couple activities and is a former president of couple activities, counselor in a Relief Society presidency, Relief Society president, and Young Women instructor. Born in Abidjan, Ivory Coast, to Christophe Ilahiri and Jeannette Boro Djedje.
Ned Cromar Hill, 65, and Claralyn Martin Hill, five children, Romania Bucharest Mission; Rock Canyon Ward, Provo Utah Edgemont South Stake. He serves as a stake Sunday School president and as chair in a volunteer care clinic in the Utah South Area. He is a former stake president, counselor in a stake presidency and missionary in the Central German Mission. Professor of finance, and former Dean of the Marriott School of Management, Brigham Young University. Born in Salt Lake City, Utah, to Richard Giles Sharp and Bettie Jean Cromar Hill.
Sister Hill serves as a Relief Society teacher and is a former counselor in a stake and ward Relief Society presidency, Young Women president, Primary teacher, nursery leader, and institute instructor. Born in Salt Lake City, Utah, to Joseph Eddy and Sara Elaine Kendell Martin.
Edward Kwame Boateng Karkari, 62, and Nana Yaa Achiaa Karkari, four children, Nigeria Lagos Mission; Teshie 2nd Ward, Tema Ghana Stake. He serves as a high councilor and is a former stake public affairs director, key city committee director for the Accra Ghana Mission, high councilor, bishop, branch president and branch mission leader. Retired chief executive officer, EcoSmart Technologies Ghana Limited. Born in Kumasi, Ghana, to Edward Kofi and Comfort Abena Agyeiwaa Karkari.
Sister Karkari serves as a visiting teacher and is a former adviser in a Relief Society presidency, visiting teaching coordinator and branch enrichment leader. Born in Accra, Ghana, to Emmanuel Kwaku and Yaa Kissiwaa Owusu.
Donald Jack Keyes, 60, and Jacquelyn Kendell Keyes, four children, Missouri Independence Mission; Uintah 2nd Ward, Ogden Utah Pleasant Valley Stake. He serves as an Area Seventy in the Utah North Area and is a former area public affairs director, stake president, counselor in a stake presidency, high councilor, bishop and missionary in the Central States Mission. Chairman, Keyes Insurance Services. Born in Ogden, Utah, to Jack W. and Ivy Lorraine Kimber Keyes.
Sister Keyes serves as an activity days leader and is a former member of an area public affairs council, member of an area council on youth, stake Young Women secretary, Young Women president, and Primary secretary. Born in Ogden, Utah, to Albert Burns and Marilyn Hope Summerill Kendell.
Dennis Ronald Sperry, 60, and Teresa Howell Sperry, six children, Philippines Quezon City North Mission; Salina 1st Ward, Salina Utah Stake. He serves as a counselor in the Utah St. George Mission and is a former stake president, high councilor, bishop, counselor in a bishopric, Scoutmaster and missionary in the Argentina North Mission. Institute Instructor, Church Educational System. Born in Nephi, Utah, to Ronald Wayne and Elma May Carter Sperry.
Sister Sperry serves as a stake Primary president and is a former counselor in a stake and ward Young Women presidency, Relief Society president and counselor, and Primary president. Born in Salt Lake City, Utah, to Evan LaMar and Luena Diane Carter Howell.
Mark Anthony Wolfert, 54, and Carol Ann Beuchert Wolfert, five children, Georgia Atlanta North Mission; Lakeridge 8th Ward, Orem Utah Lakeridge Stake. He serves as a ward missionary and is a former stake president, high councilor, bishop, counselor in a bishopric and missionary in the Germany Frankfurt Mission. Partner and General Counsel, doTERRA International. Born in Milwaukee, Wis., to Ernest Erich and Ruth Ingeborg Adler Wolfert.
Sister Wolfert serves as a counselor in a Young Women presidency and is a former gospel doctrine teacher, activity day leader, counselor in Relief Society, Young Women, and Primary presidencies and a Young Women president. Born in Calgary, Alberta, Canada, to Joseph Fredrick and Fern Matilda Baker Beuchert.


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Christopher BellDeep Fried2021-11-12T14:02:28-06:00
Christopher Bell
Mississippi House of Representatives – District 65
Christopher M. Bell, Representative, Mississippi House District 65, Chris has spent a lifetime acquiring experience around passionate and purposeful people strategy, culminating in the launch of Chris Bell Allstate Insurance Company 2005 and The Bell Group LLC in 2011.
Through his experience and education, Chris has developed a keen sense of marketing and sales expertise. Currently serves on the Executive Committee of the National Legislative Black Caucus of State Legislators. He serves on several committees which include Insurance, Public Health, Tourism, Banking and Finance, and Energy.
Chris continues to build a strong contact network through local membership in several organizations including currently serving as Board President of the Institute of the Advancement of Minority Health, Former member Board of Trustees for Leadership Greater Jackson, Omega Psi Phi Fraternity, Inc., and Anderson United Methodist Church. Chris earned his Bachelors of Science from Jackson State University.


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Avalanche Need Landeskog on the Top Line When He Returns
Leave it to the Colorado Avalanche to silence the critics. After pretty much every analyst across Canada and the United States questioned the team's ability to make it into the postseason, the Avalanche came charging out from weak footing in the Central Division to remind everyone what they're made of. Nathan MacKinnon and Mikko Rantanen
3 Potential Trade Destinations for Red Wings' Dylan Larkin
The Detroit Red Wings are working very hard to sign star center Dylan Larkin to a contract extension. Ultimately, it makes sense, as he is their captain and best forward. Yet, in a recent piece for The Fourth Period, David Pagnotta reported that the Red Wings and Larkin are "far apart in contract talks." With
Avalanche Forward Evan Rodrigues Developing Into a Key Piece
Given the injuries they have suffered so far this season, the Colorado Avalanche have been one of the toughest teams to get a real grip on, as to how good they are, and how legitimate their Stanley Cup challenge is. In a bid to put together a contending roster once again this season, the Avs
Avalanche's Rantanen Emerging Into Superstar
Mikko Rantanen has stood in the shadows of Nathan MacKinnon and Gabriel Landeskog for the bulk of his career with the Colorado Avalanche. With both of them sidelined with surgeries and injuries, he's starting to show the rest of the NHL what Avs fans have known for years — this guy doesn't need help to
NHL Rumors: Senators, Coyotes, Avalanche, Bruins, Oilers
In today's NHL rumors rundown, Alex Formenton — who was not signed by the Ottawa Senators in time to be eligible for the NHL season — has signed in Switzerland. Meanwhile, could the Arizona Coyotes contemplate trading goaltender Karel Vejmelka? The Colorado Avalanche might be the favorite to land Bo Horvat, and what is the
NHL Rumors: Oilers, Islanders, Avalanche, Canucks
In today's NHL rumors rundown, are the Edmonton Oilers thinking about taking a run at Erik Karlsson? One insider reports that the team has kicked around the idea of trying to trade for the defenseman. Are the New York Islanders a team that will have interest and the wherewithal to add someone like Patrick Kane?
2022-23 NHL Analytics Report: Georgiev, Kraken & More
Welcome to the fourth edition of the 2022-23 NHL Analytics Report, a weekly roundup of the latest analytical trends and a collection of statistical observations from around the league. To better understand the terms being used and the reasons behind their inclusion, read THW's primer on advanced analytics which explores the rapidply-growing landscape of modern hockey analysis.
3 Takeaways from the Avalanche's 3-2 Loss to the Blues – 11/14/22
The Colorado Avalanche ended a three-game home stand Monday night playing host to their division rivals, the St. Louis Blues. The Blues, who took the Avalanche to a sixth game in a hard-fought division series in the Stanely Cup Playoffs last season, came into Monday's contest with a lackluster record of 5-8-0. After losing eight
Avalanche Have 3 Second Line Center Options to Consider
Alex Newhook might well be the Colorado Avalanche's second-line center in time, but it feels like his placement there is premature. J.T. Compher has been playing more minutes than him on a regular basis, and head coach Jared Bednar makes decisions on who gets ice time based on who fills their role best. Even if
10 NHL Teams off to Unexpected Starts in October
October has concluded, and with the calendar flipping to November, some NHL teams are better or worse off than we thought they'd be to start the 2022-23 season. Are these strong starts legit, or will teams return to Earth in November? Likewise, will a club struggling out of the gate find its groove during the
Alex Newhook
Colorado Avalanche: Dominant Scoring & Defensive Woes
The numbers that matter most say that the Colorado Avalanche have five of a possible eight points. It could have been six if not for a defensive mistake in overtime against the Jets, or it could have been just three if the Wild had better goaltending. That's the wonderful thing about hockey – results don't
2022-23 Central Division Rankings: Forwards
In the third and final piece of my Central Division Rankings series, it's time to focus on the forwards. The Central Division is top-heavy on talent and features a few key players who could be on their way out by the time the 2023 trade deadline approaches. Nathan MacKinnon, Patrick Kane, and Kirill Kaprizov (The
Evan Rodrigues Might Be Avalanche's Secret Weapon
Nathan MacKinnon's new contract was easily the biggest deal of the offseason for the Colorado Avalanche. But there was another contract that flew under the radar a bit. The Avs brought in forward Evan Rodrigues on a one-year, $2 million deal late in free agency that could be a boon for a team with some
Alexandar Georgiev
Lightning Now Chasing Avalanche for Stanley Cup
Last season when the Tampa Bay Lightning were the two-time defending Stanley Cup champions, they were always predicted among the top teams to win the Cup. "You're the champions until someone proves you're not," was the mantra. When the Colorado Avalanche defeated the Lightning, they became the champs. It was a bitter pill to swallow
3 Potential Landing Spots for Kris Russell
The 2022-23 regular season is almost upon us, but Kris Russell is still a free agent and looking for a new home. However, with training camps starting soon, we have seen several players get signed to professional tryout (PTO) contracts over the last week. I expect the same thing to happen with Russell, as he
Winnipeg Jets 2022-23 Opponent Preview: Colorado Avalanche
In 2022-23, the Winnipeg Jets have 26 tilts against fellow Central Division teams — four games apiece against the Chicago Blackhawks, Colorado Avalanche, Minnesota Wild, Nashville Predators, St. Louis Blues and three games apiece against the Arizona Coyotes and Dallas Stars. In anticipation of the campaign to come, our THW Jets team's "Opponent Preview" series
Alex Chiasson
NHL Rumors: Avalanche, Canucks, Predators, P.K. Subban Update
In today's NHL rumors rundown, Evan Rodrigues has signed with Colorado Avalanche. What made him choose the Avalanche over the many teams rumored to have shown interest in the UFA? The Vancouver Canucks could look at PTOs, but they might bring a familiar face back. The Nashville Predators are expected to lose a goaltender, and
NHL Rumors: Devils, Canadiens, Oilers, Avalanche
In today's NHL rumors rundown, the New Jersey Devils were a team that went hard after a big name this offseason. It's being reported they went after two former Calgary Flames players. Meanwhile, the Edmonton Oilers are starting to extend PTO offers to a number of players. Why so many? There is talk about why


Cervical Medial Branch Radio Frequency Ablation is a treatment for a common chronic pain localized in the neck. Chronic neck pain may be a symptom of Cervical Facet Syndrome, which can be treated with cervical branch radio frequency ablation. This is a minimally invasive procedure performed under local anesthetic. The objective of the procedure is to locate and destroy part of the nerve carrying the pain signal to the brain. Following anesthesia, the nerve conducting the pain is located and the surgeon places a tiny electrode, which can emit radiofrequencies by the nerve. Emissions from this electrode will heat and cauterize the nerve, thereby eliminating the transmission of the pain to the brain.


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ExxonMobil's Altona refinery is one of those struggling in the pandemic ©David Jackmanson
Lacking refinement
The slump in fuel demand hasn't been kind to Australia's refiners, and there's now a real danger of no local fuel production at all in the future, John Rickards writes
Refining is hardly a sector that has breezed along trouble-free in recent times – three Australian refineries have closed in the past ten years – but the slump in demand caused by Covid-19 risks putting paid to two or more of the remaining four. Local fuel production, which going back a year was one of the concerns regarding Australian VLSFO availability ahead of IMO 2020, could be under serious threat as a result.
Viva Energy, the first producer to offer VLSFO in the country, is going to decide whether or not to shut its Geelong refinery in December. The company said in October that it expected to see an A$30 million loss for Q3, building on an already poor year, with low demand expected to continue into 2021.
"The company continues to incur unsustainable operating losses in this part of business and is pursuing all available options to improve cash flow and near-term profitability," Viva said in a statement.
If conditions don't improve – or the at-time-of-writing proposed offer from the government to bolster the oil sector to the tune of A$2.3 billion doesn't do enough to make refining viable, Geelong could close during the first quarter (Q1) of 2021.
Lytton refinery, operated by Ampol, could close too. In Q3 of 2020 it recorded losses of A$82m, taking the plant to A$141 million in the red for the year so far. The refinery had been closed for a time during the winter when planned maintenance was brought forward. Ampol reported in October that the Lytton plant was expected to produce
1.3 billion litres of products in Q4, more than a third of the year's total, which is down sharply from the 5.8 billion litres in 2019. The company is now carrying out a review of the refinery's future, which will "consider all options for the facility's operations and for the connected supply chains and markets it serves". Options on the table include closure, continuation and "other alternative models of operation".
Speaking about its Q3 results, Ampol managing director and CEO Matt Halliday said: "Global economic conditions triggered by Covid-19 have put significant pressure on refining, as evidenced by our performance in the first half and the significant losses announced today."
ExxonMobil Australia – which with BP Australia make up the country's other two remaining refiners – has remained tight-lipped on its own plans, but has been critical of the government's lengthy consultation process for its fuel industry support package, which could take up to six months. However, sources have suggested to local press that proposals could be finalised by December and funding available in January. Nevertheless, the company launched a voluntary redundancy program for staff in September. The Australian Workers' Union (AWU) has been quite clear that ExxonMobil's Altona refinery, as well as BP's at Kwinana, are in danger too. "These refineries support well-paid, highly-skilled blue-collar jobs in areas that desperately need them," AWU chair Mick Denton said. "Our governments can't afford to shed 5,000 of these jobs in the middle of this crisis. A shutdown of the local fuel refining sector would see a direct contraction of $6.7 billion – that's 0.36% of GDP."
In the long-term, there are companies operating routes out of Australia with an eye on a less oil-based future. In September, Eastern Pacific Shipping inked a five-ship, five-year charter deal with mining giant BHP for its dual-fuel VLOCs due to be delivered in 2022. The ships will work on BHP's iron ore routes from Australia to China, and will,
EPS said, "be the cleanest and the most efficient in the entire dry bulk shipping fleet". BHP was originally thought to be eyeing 14 dual-fuel LNG VLOCs, but seems to have scaled back its ambitions for now.
"As one of the largest dry bulk charterers in the world BHP recognises the role we play in working with our suppliers and customers to drive actionable reductions in GHG emissions across the maritime supply chain," BHP's chief commercial officer Vandita Pant said, describing the deal as marking "a progressive shift" for the industry.
"We expect the introduction of LNG-fuelled vessels will result in more than 30% lower CO2 emissions on a per voyage basis compared to conventional fuel along the Western Australia to China route."


Video is fine, but you should decide when and if they play!
(Mark Huffman @ ConsumerAffairs) The case can be made that the Internet has gotten better in recent years. More resources and faster, more targeted searches.
To turn off Flash autorun in Chrome typechrome://chrome/settings/content into the URL bar. Up pops a "content settings" page.
Are We Sharing Too Much On Facebook?
Can FaceBook and Twitter Affect Your Credit Score and Insurance?
Can Facebook videos be a scam?
Can Your Computer Make You An Easy Target For Criminals?
Find out who's searching for you On The Internet?
Microsoft To XP Users - No Internet Explorer 9 For You!
Security: And You Trust The Internet?
Security: BotNets - Is Your Computer Working For Organized Crime?
Should Businesses Fear SmartPhones & iPads?


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By Big Break Producer
DOHA, QATAR - JANUARY 27: Ian Poulter of England smiles on the 11th hole during the Pro Am prior to the start of the Commercialbank Qatar Masters at Doha Golf Club on January 27, 2010 in Doha, Qatar. (Photo by Andrew Redington/Getty Images) -
One of the hardest parts of producing a Big Break is keeping your poker face. We spend a few months of pre-production in Orlando creating the rules for all the challenges, and devising the twists and turns of the season. Then after each shooting day is over, we interview contestants that may have unwitting triggered a trap that won't spring until the next day's shoot.
For instance, at the end of day four, which corresponds with our fourth episode, I interviewed Kelly, who had bought out of the elimination challenge in that episode. So I had to ask her to talk about her decision to trade all of her points to avoid elimination, knowing full well that the next morning she would be playing a one-hole match against Natalia to avoid being sent directly to the episode 5 elimination. Evil laugh.
Episode 5 was a big day with a lot happening. Gerina Pillar returned, we played tic-tac-toe, and we had $5000 credit from Avis up for grabs. Great to meet Gerina, as I didn't work the Big Break Prince Edward Island season. She's incredibly nice, and a credit to the game, we thank her for appearing and wish her success on the LPGA Tour.
Tic-tac-toe is an idea that's been floating around for at least four seasons in different incarnations. One of the big issues has always been dealing with stalemates. In the paper game we all played growing up, two players that know strategy can force a stalemate almost every game. Golf tic-tac-toe is a bit different simply because players have to execute a shot, but we had no idea how many stalemates to expect. To protect against that concern, we used it as a first stage in a two stage immunity. Naturally we had zero stalemates. Many thanks to Range Servant for providing the net system, and to our Art Department for dressing the pieces in true Atlantean fashion.
At the end of episode 1, we always ask the contestants about the grand prize package during the night's interviews. We usually end up with a variety of responses, but certain people fixate on certain prizing. Allison was especially pumped up about the inclusion of Avis in the Grand Prize package that first night, so naturally she was pretty juiced when the episode 5 immunity prize turned out to be Avis. We couldn't have asked for a more excited winner. After hanging on and surviving a few early episodes, she vaulted up the Championship Points leaderboard in show 5. Could it be a sign of things to come?
Tune in next week...
Jon Painter
Kirk keeps card in final start on major medical
Big Breaker, NHL star Modano welcome twins
BY Bailey Mosier — July 16, 2014
Professional golfer and Big Break Atlantis alumnus Allison Micheletti and retired NHL star Mike Modano welcomed twins into the world earlier this week.
Golf TV Insider
BY Golf Channel Digital — September 14, 2012
Get ready for the new season of Big Break by watching full episodes of Big Break Atlantis. Plus, for the first time ever viewers can watch full episodes of Feherty only on GolfChannel.com.
Big Break Atlantis Champion Marcela Leon shares her feelings of excitement as she gets ready to play in her first LPGA tournament this week, the Kingsmill Championship.


Abstract: In this paper, we examine how professional forecasters' expectations and expectation uncertainty have reacted to the ECB's interest rate decisions and non-conventional monetary policy measures during the period 1999-2017. The analysis makes use of a conventional dif-in-dif type set up with different time series tools. The results indicate that expectations have been sensitive to policy actions, but all forecasters' reactions do not seem to follow the basic predictions of a standard New Keynesian model. Also the relationship between inflation and output forecasts does not seem to follow a Phillips curve type relationship. Moreover, short- and long term reactions to policy are often weakly related and of different sign. Interestingly, subjective forecast uncertainty measures are very sensitive to policy measures. Thus, there seems to be much heterogeneity in forecasters' reactions to most policy decisions. All uncertainty measures, including long-term inflation uncertainty, have increased over time. This has to be taken into account when considering the anchoring of inflation expectations to the inflation target.


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CovidCrossBorders → Kazakhstan → Visiting Poland from Kazakhstan
When will Poland open its borders to Kazakhstan and during coronavirus (COVID-19) pandemic in 2021?
2019 divided the history of most countries into «before» and «after». We are talking about a pandemic that has swept the whole world. The SARS-CoV-2 virus was first identified among residents of Hubei province (China). In just a few months, a disease called Covid-19 has spread to the inhabitants of the entire planet. Kazakhstan and Poland were not an exception.
According to current data (statistics for Sunday, 11 July 2021), the number of cases in Poland is 2 880 821 people, total deaths are 75 160, and 153 156 are sick right now. Such statistics forced the government of the state of Poland to impose certain restrictions on flights and border crossing.
Is it allowed to enter Poland from Kazakhstan?
Current statistics on the restrictions on entry to Poland:
Quarantine (lockdown) in Poland: Partial
During the most «acute» periods of the pandemic, the following restrictions are applied in Poland:
Foreigners can enter the territory of Poland only if absolutely necessary: study in Poland, employment, residence permit. For more information about the conditions of entry, read the official sources of the government: https://reopen.europa.eu/en/map/POL/6001
Availability of the test: No tests required for all countries.
In this regard, the government acts in accordance with the recommendations of the World Health Association. The distribution of states into separate categories is updated regularly. At the moment, Kazakhstan ranks among the states of the «Orange» category.
Rules for entering Poland from Kazakhstan in 2021
At the moment, Poland is partially opened to foreigners, including s. Quarantine measures are applied to tourism and trade.
Before travelling to Poland, s must pass the PCR test no earlier than 72 hours in advance and submit a written document of an international standard (in English). Also, at the time of arrival, there should be no signs of SARS (fever, chills, runny nose, cough, etc.).
Is it necessary to comply with quarantine and take a PCR test when entering Poland?
No tests required for all countries.
Quarantine for 10 days required for some travellers.
For which countries are the borders with Poland open?
Today (Sunday, 11 July 2021) the borders of Poland are fully open for 29/ 38 countries, partially open for 22/ 38 countries. See how we collect data and find out why not all countries are included in the statistics.
In Poland, bars and restaurants work with restrictions, all shops work without restrictions. Public events (exhibitions, concerts, museums, etc.) are allowed but with restrictions.
Citizens and residents of Georgia, Japan, Canada, New Zealand, Thailand, South Korea, Tunisia, Australia, Israel and United States may enter Poland without a specific reason (also for tourism).Additionally, the following categories are allowed to enter Poland from any third country:-Legal residents of Poland; -Foreigners who are close family members of Polish legal residents; -Persons holding a Polish Card («Karta Polaka») -Foreigners holding a permanent or temporary residence permit and those who have a work permit of Poland; -Persons studying in Poland; -Citizens of European Free Trade Association (EFTA) countries, European Union Member -States, and Switzerland, along with their family members; -Citizens of the United Kingdom, Belarus and their family membersNon-vaccinated persons travelling to Poland from a third country are subject to a pre-departure COVID-19 test (PCR or antigenic) taken within 48 hours prior to arrival and must self-isolate for 10 days after arrival. The quarantine may be ended earlier by a negative result to a COVID-19 test taken on day 7 after arrival.The quarantine requirement does not apply to persons who have been fully vaccinated against COVID-19 with a vaccine that has been authorised in the European Union.Children under the age of 12, travelling together with their parents who have been vaccinated against the virus or present a negative test result, are also exempted.
At the moment, there are no other restrictions on entering the territory of Poland. At the same time, the government recommends waiting for travel to countries with extremely high rates of covid-19 spread (red zone).
For which countries are the borders with Kazakhstan open?
Today (Sunday, 11 July 2021) Kazakhstan's borders are fully open to 11/ 38 countries, partially open — to 39/ 38 countries. See how we collect data and find out why not all countries are included in the statistics.
List of countries for which the borders with Kazakhstan are partially or completely open:
In Kazakhstan, bars and restaurants work with restrictions, all shops work without restrictions. Public events (exhibitions, concerts, museums, etc.) are allowed but with restrictions.
At the moment, there are no other restrictions on entry into Kazakhstan. At the same time, the government recommends waiting for travel to countries with extremely high rates of covid-19 spread (red zone).
The cheapest flights to Poland from Kazakhstan
The resumption of full-fledged air communication is gradual. At the moment, direct flights to Poland are limited, so it is possible to get to Poland with transfers. We offer the best air fares from Kazakhstan to Poland. Today you have the opportunity to book tickets at an affordable price. A pandemic is not a barrier to business and travel.
Actual data of COVID-19 in Poland
Current coronavirus statistics in Poland:
Situation with lockdown in Poland:
From 29 May:-Reopening of restaurants indoors, with a maximum occupancy of 50% and under strict sanitary regime (safe distance between tables and limit of persons per table) -Possibility to organise events such as weddings and communions indoors, with a limit of 50 people and under strict sanitary regime (safe distance between tables and limit of persons per table) -Reopening of cinemas and theatres with a maximum occupancy of 50% of the facility and under strict sanitary regime -Sports in indoor facilities and swimming pools accessible to everybody with a maximum occupancy up to 50% (with audience) -Sports in gyms and fitness clubs with a limit of 1 person per 15m2 and under strict sanitary regime -Primary and secondary schools: learning in presence for all students under strict sanitary regime
Source: https://reopen.europa.eu/en/map/POL/6001
Sick right now: 38 171
Recent morbidity: flattening
A wide variety of businesses — including gyms and fitness centers, pools, beaches, cultural facilities, museums, exhibits, entertainment centers, religious facilities, some movie theaters, food courts, and recreational facilities — are open, at least on weekdays, and may be subject to capacity limitations. However, in order to deal with the winter uptick, some regional and local governments are periodically imposing restrictions.The Chief Sanitary Doctor of Kazakhstan has mandated that masks be worn nationwide in public settings, including both indoor and outdoor spaces and on public transportation. Failure to comply with this measure could result in administrative penalty.All large events and family gatherings are prohibited. Individual and group outdoor fitness activities are permitted, and people may walk in parks and other public spaces in groups of three or less.
Source: https://kz.usembassy.gov/covid-19-information/
However, even in a pandemic, you can leave Kazakhstan for Poland with the necessary permits:


text:
Anteon jurineanum är en stekelart som beskrevs av Pierre André Latreille 1809. Anteon jurineanum ingår i släktet Anteon, och familjen stritsäcksteklar. Arten är reproducerande i Sverige.

Källor

Stritsäcksteklar
jurineanum

redpajama_set_name: RedPajamaWikipedia


text:
Справжня поліцитемія (також хвороба Вакеза) — прогресивне мієлопроліферативне захворювання, яке характеризується, передусім, збільшенням кількості еритроцитів, а у 2/3 хворих — одночасним збільшенням кількості лейкоцитів і тромбоцитів.

Етіологія та патогенез
Причини справжньої поліцитемії не відомі, проте доведено клонове походження захворювання. Основний субстрат пухлини — зрілі еритроцити, але при гіперплазії всіх трьох ростків кровотворення може бути підвищений вміст гранулоцитів та тромбоцитів. Доведено, що при еритремії рівень еритропоетину в сироватці крові знижений на відміну від вторинних еритроцитозів, спричинених гіпоксією та деякими пухлинами. Було показано, що утворення еритроцитарних колоній в культурі кісткового мозку при справжній поліцитемії відбувається без додавання еритропоетину. В зв'язку із останнім висунуто припущення, що при справжній поліцитемії еритроцитоз не регулюється звичайними фізіологічними механізмами і є автономним. Доведено наявність двох популяцій еритроцитарних колонієутворювальних клітин — одна із них являє собою нормальні еритроїдні клітини-попередники, інша є аномальною має клонове походження. Саме остання популяція клітин зумовлює розвиток захворювання і гіперчутлива навіть до незначних доз еритропоетину. При симптоматичних еритроцитозах цей феномен спостерігається досить рідко.

Отже, основним патогенетичним фактором справжньої поліцитемії є гіперчутливість стовбурової кровотворної клітини до еритропоетину і, можливо, до інших гемопоетичних факторів, що призводить в подальшому до інтенсивної проліферації усіх трьох ростків кровотворення.

Класифікація
Згідно із МКХ-10 еритремія має шифр С 92.1

Класифікація за стадіями (Wassermann, Gilbert, 1986).

І — початкова (малосимптомна); тривалість 5 років і більше.

ІІ — еритремічна (розгорнута): II А — без мієлоїдної метаплазії селезінки; тривалість -10-20 р. і більше;

II Б — з мієлоїдною метаплазією селезінки.

III — постеритремічна мієлоїдна метаплазія з мієлофіброзом і без нього.

У перебігу еритремії розрізняють три стадії (О. В. Демидова, 1969): I — початкова, перебігає безсимптомно, характеризується помірною плеторою, незначним еритроцитозом, селезінка не збільшена.

ІІ — розгорнутих клінічних проявів (еритремічна)

ІІА стадія (відсутня мієлоїдна метаплазія селезінки, спостерігається гепатоспленомегалія. У крові — еритроцитемія, тромбоцитоз, зсув лейкоцитарної формули вліво, збільшення кількості базофілів. У кістковому мозку — тотальна гіперплазія трьох ростків, мегакаріоцитоз)

ІІВ стадія — характеризується наявністю метаплазії селезінки, виражені плетора, сплено- і гепатомегалія. В аналізі крові — панцитоз, зсув лейкоцитарної формули до мієлоцитів

ІІІ — термінальна (анемічна), характеризується розвитком вторинного мієлофіброзу, анемії, тромбоцитопенії, лейкопенії. У печінці та селезінці — мієлоїдна метаплазія

Клінічні прояви
Основні симптоми еритремії зумовлені високим еритроцитозом, збільшенням об'єму циркулюючої крові, підвищенням її густини, тобто плеторою (повнокров'я). Хворіють частіше чоловіки. Захворювання розвивається поступово. Відмічаються загальна слабість, важкість у голові, головний біль, безсоння, оніміння та нападоподібний біль у кінчиках пальців, почервоніння їх (еритромелалгія), що пов'язано з підвищеним кровонаповненням судин, порушенням мікроциркуляції. Через цю причину можливе виникнення виразок дванадцятипалої кишки та шлунка. Нерідко спостерігаються тромбози великих артерій, інфаркти міокарда, тромботичний інсульт, тромбофлебіти у зв'язку з уповільненням кровотоку, збільшенням густини крові. Але можуть бути й кровотечі різної локалізації внаслідок переповнення судин кров'ю, функціональною неповноцінністю тромбоцитів. Часто непокоїть свербіж шкіри, особливо після купання, умивання.

Характерний загальний вигляд хворих на еритремію: шкіра та слизові оболонки вишнево-червоного кольору, кон'юнктива гіперемійована («очі кролика»). Ця симптоматика спостерігається у 95-98 % хворих. На щоках і кінчику носа часто спостерігаються телеангіектазії. Іноді на шкірі з'являються висипання подібні до кропивниці, acne vulgaris, acne rosacea. Артеріальний тиск підвищений. Характерними особливостями артеріальної гіпертензії при даному захворюванні є більш частий розвиток ускладнень (недостатність коронарного кровотоку з нападами стенокардії, інфарктом міокарда, недостатність мозкового кровотоку) в порівнянні із хворими без гіпертензії. При дослідженні очного дна виявляється набряк зорового нерва, застійні звиті судини.

Печінка може бути збільшена (внаслідок мієлоїдної метаплазії та підвищеного кровонаповнення). Описаний розвиток синдрому Бадда-Хіарі, обумовленого оклюзією печінкових вен. Більш ніж у 90 % хворих спостерігається збільшення селезінки.

Діагностика
Діагностика еритремії базується на цитоморфологічному дослідженні крові, кісткового мозку, даних додаткових методів обстеження. Запідозрити еритремію можна в чоловіків у разі збільшення рівня гемоглобіну понад 170 г/л, кількості еритроцитів більше ніж 6 • 1012/л, у жінок- відповідно 150 г/л та 5,3 • 1012/л. Найінформативнішим є визначення загального об'єму еритроцитів за допомогою радіологічного методу, який при еритремії в чоловіків перевищує 36 мл/кг, а в жінок — 32 мл/кг. Окрім згаданих вище показників у хворих із справжньою поліцитемією виявляють збільшення рівня гематокриту, з прогресуванням захворювання приєднується тромбоцитоз, може спостерігатися лейкоцитоз із зсувом лейкоцитарної формули вліво до мієлоцитів; у 5—8 разів зростає в'язкість крові. ШОЕ різко зменшена (0 — 2 мм/год). Збільшення активності лужної фосфатази нейтрофілів (180—300 у.о.) є патогномонічним для еритремії.

Дослідження пунктату кісткового мозку часто малоінформативне, тому для верифікації діагнозу доцільно проводити гістологічне дослідження кісткового мозку (трепанобіопсію), за яким визначають гіперплазію еритроцитарного або всіх трьох ростків мієлопоезу, помірне збільшення кількості еритро- і нормобластів. Це дослідження дозволяє віддиференціювати еритремію від мієлофіброзу. У першому випадку має місце повне заміщення жирового депо гіперплазованою гемопоетичною тканиною, особливо мегакаріоцитами, явища фіброзу відсутні або незначні. При другій патології виявляють змінену архітектоніку кістки, гемопоетична тканина витіснена сполучною.

У сироватці крові у хворих на еритремію виявляють підвищений рівень вітаміну В12, збільшення в'язкості крові, високий гематокрит, високий рівень сечової кислоти. У хворих із частими кровопусканнями може розвиватися сидеропенія.

Для об'єктивізації діагностики еритремії запропоновано стандартизовані критерії симптомів.

Категорія А

А1 Збільшення загального об'єму еритроцитів понад 36 мл/кг у чоловіків та 32 мл/кг у жінок

А2 Нормальне насичення артеріальної крові киснем

АЗ Спленомегалія

Категорія В

В1 Тромбоцитоз понад 400 г/л

В2 Лейкоцитоз понад 12 г/л

ВЗ Показник активності лужної фосфатази нейтрофілів понад 100 у.о. Підвищений рівень вітаміну В12

Діагноз вважають вірогідним, якщо у хворого наявні всі три критерії категорії А або два критерії категорії А у поєднанні з двома будь-якими критеріями категорії В.

Диференціальна діагностика
Захворювання необхідно диференціювати із вторинними та відносними еритроцитозами. Вторинні еритроцитози можна розподілити на фізіологічні, тобто такі, що виникають унаслідок компенсаторної гіперпродукції еритропоетину, та еритроцитози внаслідок неадекватної продукції еритропоетину. До першої групи відносять: гіпоксичний стан у результаті перебування на висоті, серцево-судинні захворювання, особливо природжені вади серця, захворювання легенів з альвеолярною гіповентиляцією, у завзятих курців, метгемоглобінемії, сімейні поліцитемії (наявний аномальний гемоглобін з високою афінністю до кисню). До другої групи відносять такі захворювання нирок, як гідронефроз, кісти та гіпоксію нирок унаслідок тромбування ниркових артерій, а також масивні фіброміоми матки, первинний рак печінки на початкових стадіях та гемангіому мозочка.

До відносних еритроцитозів належать еритроцитози, які виникають унаслідок зменшення ОЦП та вторинного згущення крові з відносним переважанням кількості еритроцитів в одиниці об'єму крові — при зневодненні організму, перерозподілі плазми крові, при опіках, нейросудинних реакціях.

Критерії діагнозу:

-наявність плеторичного синдрому: вишнево-червоне забарвлення шкіри і видимих слизових, артеріальна гіпертензія

еритромелалгія, тромбози, геморагічний синдром; — спленомегалія;

-зміни в периферичній крові: панцитоз, збільшення гемоглобіну, гематокриту, зменшення ШОЕ; — гіперплазія червоного, гранулоцитарного, мегакаріоцитарного ростків кісткового мозку за даними стернальної пункції; — триросткова проліферація в кістковому мозку із витісненням з нього жиру (за даними трепанобіопсії кісткового мозку); — низький рівень еритропоетину в крові; — відсутність причин для розвитку вторинних еритроцитозів.

Приклади формулювання діагнозу:
 Еритремія: ІІ А стадія; тромбоз судин правої нирки, вторинна гіпертензія, І ступеня; СН 0.
 Еритремія: І стадія, вторинна гіпертензія, II ступеня; СН 0.
 Еритремія: III термінальна стадія; шлунково-кишкова кровотеча [дата], важкого ступеня; панцитопенія

Лікування

 Режим — залежно від стадії захворювання.
 Дієта — залежно від ураження внутрішніх органів.
 Медикаментозно: Найширше для лікування еритремії застосовують кровопускання на фоні терапії антикоагулянтами: перед проведенням кровопускання хворому підшкірно в передню черевну стінку вводять 5000 ОД гепарину. Якщо виникає загроза тромбоутворення, у наступні після кровопускання дні можна продовжувати застосування антикоагулянтів прямої дії в половинних дозах. Обов'язковим є проведення гемодилюції сольовими розчинами або низькомолекулярними декстранами (реополіглюкін), які покращують мікроциркуляцію. З метою профілактики тромбоутворення призначають дезагреганти: трентал, дипіридамол (курантил), тиклід, аспірин.

Хороший ефект має еритроцитоферез. За одну процедуру видаляють 1000—1600 мл еритроконцентрату, що містить 7,5-14x109/л еритроцитів. Маніпуляцію повторюють 1-3 рази з інтервалами 5-7 днів.

Цитостатичну терапію застосовують у хворих з вираженою проліферацією тромбоцитарного або всіх трьох ростків гемопоезу, прогресуючим збільшенням селезінки або печінки.

Тепер у лікуванні еритремії використовують мієлосан, який призначають при гіпертромбоцитозі та прогресуючій спленомегалії в дозі 2—6 мг на добу тривалістю не більше ніж 4—6 тиж. Короткий період застосування пояснюється вираженим мієлосупресивним впливом препарату.

Гідроксисечовина — цитостатик, який впливає на проліферувальні клони клітин, призначають у дозі 1—1,5 г на добу. Препарат дає короткотривалий ефект, тому паралельно проводять кровопускання.

Хворим з гіперурикемією показаний алопуринол (мілурит). Пацієнтам, яким часто проводять кровопускання, допускається призначення препаратів заліза, оскільки в них часто розвивається сидеропенія.

Інтерферони — пригнічують патологічну мієлопроліферацію, знижують продукцію тромбоцитів і лейкоцитів. Альфа-інтерферон призначають по 3*106 МО/м2 через день п/ш; тривалість лікування — 12 міс. і більше.

Останнім часом широко застосовують препарат гідреа, який є антиметаболітом. Для індукції ремісії призначають гідреа по 30 мг на 1 кг маси тіла на добу щоденно протягом 1-2 тиж, при зменшені тромбоцитів і лейкоцитів доза препарата знижується до 15 мг на 1 кг маси тіла. Підтримуюча доза 0,5-1 г на добу.

Прогноз
Захворювання може тривати багато років, в період якого хворі зберігають клінічну компенсацію і працездатність, однак повного видужання не буває.

Посилання
 Еритремія (істинна поліцитемія, еритроцитоз, хвороба Вакеза) - симптоми хвороби, профілактика і лікування, причини захворювання, діагностика

Захворювання крові
Онкологічні захворювання


text: Q: Force required to drive an electric vehicle I am looking for the equation to calculate the energy required to move an electric vehicle of simply design based on rolling resistance, weight, wheel radius and air friction.  The idea is to build a digital model with varying values for these inputs and see what rate power is drained from the battery once at a constant speed (around 30mph but may wish this to be variable as well - say 33mph).

redpajama_set_name: RedPajamaStackExchange


text:
Q: How to use Jenkins credential store when accessing CVS? Is there a way to use the credential store with the CVS plugin to access a CVS repository? Looking for a way to store credential once and have one place to change it, despite many jobs making use of it.

A: The CVS plugin doesn't use the credentials store directly (although there are potential plans to move to this in a future overhaul of the plugin), but it does have a concept of global credentials which should provide what you need. The reason for having something separate from global credentials was that CVS introduced this prior to the credentials plugin being available and the steps have never been taken to try and perform a migration.
To use this credential feature, ensure you have version 2.4 or above of the CVS plugin, goto your 'Manage Configuration' screen, scroll down to the CVS section and click the 'Add' button next to the 'Authentication' option. Once you've added any credentials in here, go back to the jobs you're wanting to use the global credentials on, check the CVS root matches what you put in the authentication section and that it doesn't contain a username and then run your job. When running, the console should then show 'Using globally configured credentials for...' when trying to connect to CVS.


J loves to paint. So to go along with our Flight of the Bumblebee music appreciation, I came up with this adorable bumblebee craft that combines music and art.
First, I printed off a copy of the sheet music for "The Flight of the Bumblebee" from here. I chose to do a piano version by Rachmaninoff based on Rimsky-Kosakov's theme, but pick anything that you'd like. Then I gave the boys some black and yellow tempera paint.
To set the mood, I played a recording of "The Flight of the Bumblebee" from this cd. You can also use a recording from youtube if you'd like. With the music playing in the background, it was finally time to paint.
It's so interesting, to me at least, to see how J and K approach an art project. They are so different. J, for instance, started off by painting out the words "The Bumble Bee."
He also wrote "the waters" and the number 33.
Then he finally painted it like crazy, while staying almost completely clean and paint free.
K, on the other hand, got messy. He's a toddler, what else can I say.
Once the paint was dry, I cut out bumblebee shapes from their paintings. I then cut out two wings for each bee. I used vellum for the wings and fastened them to the bee body using a brad fastener, which means the wings can rotate. Then I drew a smile and glued a googly eye onto each bee.
And here is J's bee. You can see the number 33 still on the body.


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This paper focuses on the positives of introducing entrepreneurship education at the primary and secondary levels of education. Specifically, its central focus deals with building children's entrepreneurial self-efficacy at a young age. Several benefits, of increasing self-efficacy at a young age, are outlined. Benefits, such as entrepreneurship training, not only train students but, it helps to prepare them for the new knowledge based economy. Further, entrepreneurship education should help increase the success and survival rates of women and minority entrepreneurs. Essential to this process, a new curriculum needs to be devised including its means of assessment. Lastly barriers to an entrepreneurship program are discussed; this includes financial, political and negative perceptions of entrepreneurship education.
Athayde, R. 2009. Measuring enterprise potential in young people. Entrepreneurship, Theory and Practice, 33(2): 481-500.
Bandura A. 1977a. Self-efficacy: Toward a unifying theory of behavioral change. Psychological Review 84(2): 191-215.
Bandura, A. 1977b. Social Learning Theory Prentice Hall: New Jersey.
Bandura. A. 1997. Self-efficacy The exercise of control. W.H. Freeman and Company: New York.
Birley, S., Moss, C., & Saunders, P. 1987. Do women entrepreneurs require different training? American Journal of Small Business, 12: 27-35.
Brawer, F. B. 1997. Simulation as a vehicle in entrepreneurship education. ERIC Digest Number 97-1, ED 433-468.
Bryant, P.C.; Fabian, F.; Kinnamon, E., & Wright, P. 2012. Tailoring Entrepreneurship Education: Exploring components of Entrepreneurship Education for Underrepresented Groups. Journal of Business & Entrepreneurship Winter 2012: 1-24.
Carter, N.M.; Williams, M.; & Reynolds, P.D. 1997. Discontinuance among new firms in retail: The influence of initial resources, strategy, and gender. Journal of Business Venturing, 12 (2): 125-145.
Charney, A. H., & Libecap, G. D. 2002. The contribution of entrepreneurship education: An analysis of the Berger Program. International Journal of Entrepreneurship Education, 1: 385-418.
Chen, C. C., Greene, P. G., & Crick, A. 1998. Does entrepreneurial self-efficacy distinguish entrepreneurs from managers? Journal of Business Venturing, 13(4): 295-316.
Consortium for Entrepreneurship Education (CEE) http://www.entre-ed.org. Entrepreneurship Everywhere: The Case for Entrepreneurship Education. 2013. http://www.entre-ed.org/_entre/whitepaperfinal.pdf retrieved February 25, 2013.
DeNoble, A. F., Jung, D., & Ehrlich, S. B. 1999. Entrepreneurial self-efficacy: The development of a measure and its relationship to entrepreneurial action. Frontiers of Entrepreneurship Research Boston Babson College.
Department of Labor (DOL) Futurework-Trends and Challenges for Work in the 21st Century A report of the United States Department of Labor Alexis M Herman Secretary Labor Day 1999.
DeTienne, D., & Chandler, G. 2004. Opportunity Identification and its role in the entrepreneurial classroom: A pedagogical Approach and Empirical Test. Academy of Management Learning and Education 3(3): 242-257.
Dwyer, W. G. Jr. & Handler W. 1994. Entrepreneurship and family business: Exploring the Connections. Entrepreneurship Theory and Practice, 19(1), 71-83.
Fairlie, R., & Woodruff, C. 2010. Mexican-American Entrepreneurship. The B.E. Journal of Economic Analysis & Policy, 10 (1), online.
Gerber, S. 2013 http://business.time.com/2012/03/05/how-entrepreneurship-can-fixyoung-america/ retrieved February 20, 2013 11:50 AM TIME Magazine.
Gibb, A. 1993. The enterprise culture and education. International Small Business Journal, 11(3): 11-34.
Gibb, A. 2000. SME policy, academic research and the growth of ignorance: Mythical concepts, myths, assumptions, rituals and confusions. International Small Business Journal, 18(3): 13-35.
Hess, F. M. 2007. The Case for Educational Entrepreneurship: Hard Truths about Risk, Reform, and Reinvention. The Phi Delta Kappan, 89(1): 21-30.
Kuratko, D. F. 2004. Entrepreneurship Education in the 21st century: from Legitimization to Leadership. Coleman White Paper series, www.usabe.org.
Kuratko, D. F., Ireland, R. D., & Hornsby, J. S. 2001. Improving firm performance through entrepreneurial actions: Acordia's corporate entrepreneurship strategy. Academy of Management Executive, 15 (4): 60-71.
Mann, P. H. 1990. Nontraditional business education for black entrepreneurs: Observations from a successful program. Journal of Small Business Management, 28(2): 30.
Morris, M. H. & Kuratko, D. F. 2002. Corporate Entrepreneurship. Mason, OH: South-Western College Publishers.
Neck, H. M., & Greene, P. G. 2011. Entrepreneurship education: Known worlds and new frontiers. Journal of Small Business Management, 49(1): 55-70.
Network for Teaching Entrepreneurship. 2013. http://www.nfte.com/what retrieved 4/12/2013.
Peterman, N.E., & Kennedy, J. 2003. Enterprise education: Influencing students' perceptions of entrepreneurship. Entrepreneurship Theory and Practice, 28(2): 129-144.
Robb, A. M. 2002. Entrepreneurial performance by women and minorities: the case of new firms. Journal of Developmental Entrepreneurship, 7: 383-398.
Scherer, R., Brodzinski, J., & Wiebe, F. 1990. Entrepreneur career selection and gender: A socialization approach. Journal of Small Business Management, 28(2): 37-44.
Singh, R. P., Knox, E. L., & Crump, M. E. S. 2008. Opportunity Recognition differences between black and white nascent entrepreneurs: A test of bhave's model. Journal of Developmental Entrepreneurship, 13(1): 59-75.
Solomon, G. T., Duffy, S., & Tarabishy, A. 2002. The state of entrepreneurship education in the United States: A nationwide survey and analysis. International Journal of Entrepreneurship Education, 1(1): 65-86.
The Mind Trust Enabling Talented Innovators to Change Education. The Mind Trust.
Timmons, J. A. & Spinelli, S. 2009. New Venture Creation Entrepreneurship for the 21st Century (8th ed.). McGraw-Hill Irwin.
Walstad, W., & Kourilsky, M.L. 1998. Entrepreneurship attitudes and knowledge of black youth. Entrepreneurship Theory and Practice, 23(2): 5-18.
Wilson, L., & Davis, L. 1973. Problems of black business. Journal of Small Business Management, 11: 1-5.
Wilson, F., Kickul, J., & Marlino, D. 2007. Gender, entrepreneurial self-efficacy, and entrepreneurial career intentions: Implications for entrepreneurship education. Entrepreneurship Theory and Practice, 31(3): 387-406.
Wilson, F., Kickul, J., Marlino, D., Barbosa, S., & Griffiths, M. 2009. An analysis of the role of gender and self-efficacy in developing women entrepreneurial interest and behavior. Journal of Developmental Entrepreneurship, 14(2): 105-119.
Wilson, F., Marlino, D., & Kickul, J. 2004. Our entrepreneurial future: Examining the diverse attitudes and motivations of teens across gender and ethnic identity. Journal of Developmental Entrepreneurship, 9(3): 177-197.
White house.gov. 2013. http://www.whitehouse.gov/startup-america-fact-sheet retrieved Friday February 22, 2013 http://www.kauffman.org/Section.aspx?id=Education retrieved Friday February 22, 2013.
Vesper, K. H. & McMullen, W. E. 1988. Entrepreneurship: Today courses, tomorrow degrees? Entrepreneurship Theory and Practice, 13(1): 7-13.
Young, M. 2002. An examination of information sources and assistance programs available to minority-owned small business. Journal of Developmental Entrepreneurship, 7(4): 429-444.
Zahra, S. A., Kuratko, D. F., & Jennings, D. F. 1999. Corporate entrepreneurship and wealth creation: Contemporary and emerging perspectives. Entrepreneurship Theory and Practice, 24 (2): 5-9.


text:
Der Autonome Kreis Harqin Linker Flügel der Mongolen (; mongolisch ), kurz Kreis Harqin Linker Flügel () oder Kreis Kazuo (), ist ein autonomer mongolischer Kreis der bezirksfreien Stadt Chaoyang (朝阳市) im Westen der Provinz Liaoning in der Volksrepublik China. Er hat eine Fläche von 2.244 km² und zählt 346.133 Einwohner (Stand: Zensus 2020). Sein Hauptort ist das Straßenviertel Dachengzi (大城子街道).

Die denkmalgeschützte Dongshanzui-Stätte der Hongshan-Kultur befindet sich auf seinem Gebiet.

Weblinks

 Offizielle Website (Kazuo) ()

Einzelnachweise

Ort in Liaoning
Autonomer Kreis / Autonomes Banner (China)


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text:
FreeFi Gets Travelers Online At OAK
Oakland International (OAK) now has new Wi-Fi service thanks to FreeFi Networks.
It is the second deployment for the Los Angeles, Calif.-based company's content- and advertiser supported Public Internet Wi-Fi access; the first was at Denver International (DEN) in January. Service began Oct. 1 under a multi-year contract with OAK.
"Because Oakland International is the preferred airport for many business travelers in the Bay Area, it was the perfect location for our next major airport launch," says Richard Bogen, FreeFi's managing director. "After working with us for less than a year, Denver International Airport has become the world's largest free Wi-Fi airport and is exceeding the revenue it made in previous years with its paid Wi-Fi service. We anticipate that Oakland will experience the same level of success."
FreeFi's sponsors include Microsoft, Toyota, Verizon, American Express, Charles Schwab, Holiday Inn, Zappos.com, Ford and Toshiba.
"The Port of Oakland selected FreeFi to provide this new service for Oakland International Airport because of the company's reliability, service and proven revenue model," said Steve Grossman, Director of Aviation for the Port. "We are pleased to offer this free service to our travelers, allowing them to keep in touch with business and personal contacts between flights."
FreeFi works in conjunction with equity and technical partner Front Porch using the Ultramercial platform. It creates custom and venue-specific environments, and soon plans to offer free and paid content to its users, such as games from Real Networks and Disney Video on Demand movies.
"Airport environments are perfect for advertiser-supported Internet access," says Lawrence Laffer, FreeFi's director of sales and marketing. "Air travelers like Wi-Fi, but don't like paying for it. Our sponsors take care of that, but with a much higher ROI than signage and other forms of airport advertising. FreeFi provides marketers with significantly longer exposure time to their target audience through an unobtrusive marketing presence, far beyond what's available through traditional modes of advertising."
November Features Slew Of Openings At DEN
2 Airports Expand Recycling Efforts


text:
Anti-Immigrant New Mexico Governor Reveals Her Grandparents Were Undocumented Immigrants
Marie Diamond Sep 9, 2011, 1:40 pm
New Mexico Gov. Susana Martinez (R) has long been known for her vitriolic rhetoric against undocumented immigrants. Just this week, she slammed presidential contender Rick Perry (R-TX) for once supporting the DREAM Act and comprehensive immigration reform. "It is not comprehensive reform to put people who are here illegally, who violated the law, and put them in front of the line for those folks who have been waiting and doing all the right things to come to the United States," she said.
But on Wednesday, Martinez surprised many when she admitted that her own grandparents were among those "people…who violated the law" when they came to the U.S. as undocumented immigrants:
New Mexico Gov. Susana Martinez has acknowledged her paternal grandparents came to the U.S. illegally, amid national attention and protests over her ongoing efforts to bar illegal immigrants from getting driver's licenses.
"I know they arrived without documents, especially my father's father," the Republican said Wednesday in an interview in Spanish with KLUZ-TV, the Albuquerque Univision affiliate. […]
Martinez has made headlines recently for her push to repeal a state law that lets illegal immigrants get a New Mexico driver's license. She has added the issue to the agenda for a special session on redistricting that opened Tuesday.
This is the first time Martinez has definitively answered questions about her grandparents' immigration status, and admitted that she would not be in this country — let alone be a governor — if they had not entered the U.S. without papers. At a rally yesterday against Martinez's effort to repeal the driver's license law, protesters held placards that read, "Dear Susana. Do you know your history? Did you forget your roots?"
Martinez's office was quick to preemptively denounce anyone who would "personally attack the governor" for this revelation. But given her hard-line stance and willingness to separate other families who are undocumented, many activists hope she will keep her own roots in mind when issues like the DREAM Act come up.
This week, Martinez reiterated, "I don't support piecemeal legislation such as the DREAM Act." However, Martinez should know better than anyone that we don't control our parents' or grandparents' actions, and shouldn't be punished for them.


Celebrities can be pretty exclusive about the accounts they follow on social media, which is why some stars' unusual decisions about whom to follow (or not follow) are fascinating.
Seth Rogen follows Instagram accounts whose sophistication may clash with his cinematic persona.
Rogen follows dozens of galleries, museums and artists, including pop-culture artist Jeff Koons.
The Instagram feed of Kourtney Kardashian's ex, Scott Disick, may be more refined than Rogen's.
Design, décor, hospitality, luxury-car and architecture brands make up his 15 Instagram follows.
None of his 15 follows is directly affiliated with a Kardashian (Kourtney or otherwise).
Weeks after joining Twitter in 2010, Conan O'Brien tweeted he'd follow "someone at random."
That "someone" was Sarah Killen, a 19-year-old student who had three followers back then.
As of July, O'Brien's account still follows only Killen's, which now boasts 356,000 followers.
The satirical account @TheTweetOfGod follows just one transcendent figure: Justin Bieber.
Former Vice President Al Gore follows presidents Bill Clinton and Barack Obama on Twitter.
But Gore also follows a fellow "Veep," albeit a fictional one, in actress Julia Louis-Dreyfus.
Some stars take social-media exclusivity to a new level, opting not to follow a single soul.
As of July 2016, Emma Watson didn't follow anyone at all on Instagram.
Eminem, Rev. Run, Kathy Griffin, Zach Galifianakis and the Dalai Lama follow nobody on Twitter.
As of late July, those five celebrities' combined Twitter follower count approached 44 million.
Another member of the no-follow Twitter club is Jay Z, despite more than 3.2 million followers.
But while his wife Beyoncé takes that same approach on Instagram, Twitter is another story.
There, Beyoncé follows 10 people, including Mariah Carey, Usher and members of Destiny's Child.
But one name is notably absent from Beyoncé's short Twitter-follow list: Jay Z.


Third and fourth class hurlers and camogie players are partaking in indoor blitzes run by Sciath na Scol during the month of February.
We would like to congratulate both our Junior and Senior Quiz Teams who represented our school at the recent Credit Union Quiz in Scoil Mhuire gan Smál, Blarney, on Friday 27th January. We are delighted to report that our Junior Team won the Under 11 division and will now represent our school in the County Finals.
Cloghroe N.S. will be well represented at this year's Scór na bpáistí with a solo singer, a solo instrumentalist, an Irish dancer and an instrumental group.
Transition Year students from Ballincollig Community School are training our fifth class children in Spike Ball. This is in preparation for the upcoming blitz in Ballincollig on February 17th.
Sixth class children are training for the upcoming Primary Schools Basketball Tournament in Neptune and Parochial Hall on February 14th and 16th.
Our Active School's campaign is doing very well. On February 10th, in line with Operation transformation, we will do 10 @ 10 – 10 minutes of exercise throughout the school. Morning Muscles is back up and running on Monday and Wednesday mornings before school. The children of 3rd and 4th class are very enthusiastic and have been making a great effort to attend and are giving it their all!
On February 3rd, we will have a Biodiversity Display in the hall and all children will get a chance to visit. Thanks to Ms. Twomey and he Green Schools Committee for organising this event.
The boys and girls at Cloghroe N.S. have been learning fantastic new dances with the girls from the 'Spraoi' team. They have also been getting active in Folk Dance classes and are loving the opportunities to express themselves through dance. We are also really enjoying our "Folk Dance" classes on Thursdays where we are experiencing different dance styles from around the world.
Fourth Class will visit the Lifetime Lab next week.
We will be studying Internet Safety in the lead up to Internet Safety Day on February 6th.
Guitar Lessons: have started during lunch break on Wednesdays in Mr. Whitty's room for sixth class children.


text:
Q: using the youtube API with an iframe and not a div According to the youtube API, you should be able to create the iframe tag myself and still use the YT.Player object. I need to do this because my embedded video id is going to be from the server and I don't want javascript in script tags.
I am trying to get an image to show as the poster for the video.
I do have a fiddle, I just cannot seem to get the YT.Player to actually work. On image click it's supposed to trigger the autoplay and when the player ends it is supposed to go away, though I will probably just hide it again.
My Html

My Javascript
$("#container.click-to-play-video").click(function(){
    $('#player').show();
    $('#head').css({"background-color":"black"});

    player = new YT.Player('player', {
        playerVars: { 'autoplay': 1 },
        events : {
            'onReady' : onPlayerReady,
            'onStateChange' : onPlayerStateChange
        }
    });
});

var tag = document.createElement('script');
tag.src = "https://www.youtube.com/iframe_api";
var firstScriptTag = document.getElementsByTagName('script')[0];
firstScriptTag.parentNode.insertBefore(tag, firstScriptTag);

var player;
function onPlayerReady(event) {
    //event.target.playVideo();
}
function onPlayerStateChange(event) {
    if(event.data == YT.PlayerState.ENDED) {
        player.destroy();
        $('#head').css({"background-color":"#aaa"});
    }
}

Here is the fiddle http://jsfiddle.net/eLt4aybd/79/


text:
Treatment and Survival Differences in Patients With Urothelial Vs. Nonurothelial Bladder & Upper Tract Carcinomas - Jeanny Aragon-Ching
Sam Chang and Jeanny Aragon-Ching discuss treatment and survival differences in patients with urothelial versus non-urothelial bladder and upper tract carcinomas an analysis from the National Cancer Database (NCDB). There is an increased need for learning more about urothelial and non-urothelial cancers because non-urothelial cancers typically have been known to have a worse prognosis than urothelial cancers. Dr. Aragon-Ching highlights a retrospective review she presented at GU ASCO 2022 in which the objective was to further describe the patterns, demographics, stage, metastasis, and response to chemotherapy and immunotherapy explored through the National Cancer Database.
Biographies:
Jeanny Aragon-Ching, MD, Clinical Program Director of Genitourinary Cancers, the Inova Schar Cancer Institute, Associate Professor of Medical Education, University of Virginia, Fairfax, VA
Sam S. Chang, M.D., M.B.A. Patricia and Rodes Hart Endowed Chair of Urologic Surgery Professor Department of Urology at Vanderbilt University Medical Center
Non-muscle Invasive Bladder Cancer: Overcoming Diagnostic and Therapeutic Challenges
Read the Full Video Transcript
Sam Chang: Hello, everyone. My name is Sam Chang. I'm a urologist in Nashville, Tennessee, and I work at Vanderbilt University. And we are all quite fortunate to have Dr. Jeanny Aragon-Ching. Jeanny's the Clinical Program Director of GU Cancers at the Inova Schar Cancer Institute in Fairfax, Virginia. And she's going to be giving an updated presentation for what she presented at GU ASCO 2022. And then we'll spend a few minutes kind of asking her and probing her thoughtful mind of where the next steps are going to be in terms of urothelial carcinoma. So we'll start off with Jeanny. Jeanny, thank you so much for spending time with us.
Jeanny Aragon-Ching: Sam, thank you so much and for UroToday, too, for giving us a little bit of insights on the abstract that I presented at GU ASCO.
So this is the treatment and survival differences in patients with urothelial versus non-urothelial bladder and upper tract carcinomas and analysis from the National Cancer Database. And as we all know, bladder cancer occurs in about 81,000 patients, and there is an increased need for learning more about urothelial and non-urothelial cancers because non-urothelial cancers typically have known to be worse prognosis than urothelial cancers. So the objective really of this dataset is to further describe the patterns, demographics, stage, metastasis, and response to chemotherapy and immunotherapy explored through the NCDB.
So this is what we did. It was a de-identified dataset from NCDB ranging from 2004 to 2017. And we used these different histologic terms to define transitional cell or urothelial cell carcinoma versus the non-urothelial cancer cell cohorts. And using chi-square tests, Kaplan-Meier method, and log-rank tests, a statistical analysis to look at the data.
And in total, we had 649,000 patients and as expected, there were more urothelial cancers compared to the non-urothelial cancer patients. Majority of patients were men, as expected, again. Upper tract cancers, 62%, 75% for bladder for men. And median age is actually very similar across the board. Majority were Caucasian men. And interestingly enough, there were more African-American patients in the non-urothelial cancer cohorts, about twice as much, 10.8%, compared to 5.26%.
Now, primary surgery occurred more frequently in the patients with urothelial cancer, 94.7%, compared to the non-urothelial cancer cohorts. And this is the high-level data that we saw. In stage zero and one patients you will see that urothelial cancer patients had a better median overall survival compared to the non-urothelial cancer patients. On the other hand, as stage increases towards stage two and three, as well as stage four cancers, we see that the curves soon to be are overlapping. Whereas on the right-hand side of your slide, you will see the effects of chemotherapy. So effects of chemotherapy on the urothelial cancer cohort certainly is more favorable, median survival's about 73 months compared to only 17 months for the non-urothelial cancer cohorts. On the other hand, immunotherapies affects similarly is more favorable for the urothelial cancer, about 115 months median survival compared to only about 64.5 months.
So in summary, urothelial cancer of both bladder and upper tract origin compared to the non-urothelial cancer cohort tend to have a better prognosis in both presentation, as well as even treatment with chemotherapy or immunotherapy. This highlights the need for better therapeutic strategies for patients with non-urothelial cancers. And with that, thank you so much for your attention.
Sam Chang: Jeanny, thank you so much. I think the presentation, just like every great presentation, just asks many more questions that are out there. So some of the questions I had in mind are, and you may not know this because it's tough sometimes in the NCDB, but were there certain subtypes, and this is dangerous whenever you go back and you try to parse out more, certain subtypes that seem to be worse than other subtypes in the non-urothelial cancers?
Jeanny Aragon-Ching: Yes. And we actually had an earlier dataset that looked at the fine-tuning or details of the non-urothelial cancer subsets. On the other hand, we know that certain histologies, like adenocarcinoma tend to do worse than, let's say, as well as like small cell carcinoma patients, for instance. But to your point, Sam, we have yet to dissect all the non-urothelial cancer cohorts to see which one of the group actually fares a little better than the others.
Sam Chang: And then, did you notice, as you parsed out kind of the urothelial versus non-urothelial and you had different stages, as a group, did the non-urothelial, and you may, again, not be able to tell this, but did they tend to present at a similar stage for a stage or they tended to be later and more progressive in terms of disease?
Jeanny Aragon-Ching: Yeah. It tends to be later and more, and that's what we see in clinical practice too, which is they typically present at the later stage and metastatic for whom the opportunities for early cure unfortunately, is not available to everyone.
Sam Chang: So, as you consider non-urothelial carcinomas... As our medical oncologists struggle with, we don't really know, there's no best set regimen that we know of. And each one may have nuances, a squamous cell versus an anode, versus a small cell. We're basically guessing. In terms of these kind of very small populations, but clearly that do worse, where do you think the next step should be in terms of study? Should we parse them out only for small cell or do we start off with, as a group, non-urothelial? What are your thoughts regarding that?
Jeanny Aragon-Ching: Yeah. Again, by sheer numbers alone, the limitation of the numbers, I think creating or designing a trial that would encompass all of the non-urothelial cancer patients as a catchment, for instance. And of course, several studies come to mind, including ICONIC, which will capture all of the patients with rare GU cancers. And from that sort of basket trial, we can hopefully glean a little bit more on the treatment paradigms and the treatment in general.
And the one thing I would say about the limitation from a lot of these cancer databases is of course the lack of granularity, right? So when we look at the outcomes from chemotherapy or immunotherapy, for instance, there is no real detail about, is it cisplatin-based chemotherapy or toxin base? What about the immunotherapy, what drugs were used? So there's no ability to fine-tune what those treatments are.
Sam Chang: Right.
Jeanny Aragon-Ching: One thing I would also say is the database captured until 2017. So, that was around the time when immunotherapy drugs were starting to first come to the clinic. So there's still a lot of data we have not captured. So I would say stay tuned for more.
Sam Chang: Right. Yeah, I think very interesting would be that from 2017 to say, 2022, these next five years when we really have incorporated kind of standard of care for those patients that are not eligible for chemotherapy, what happens when they get immunotherapy? And we may have already selected out the worst actors early on.
Jeanny Aragon-Ching: Exactly.
Sam Chang: It'll be very interesting. As you look at the NCDV, which is, you just pointed out some of the weaknesses, but it is very real world.
Jeanny Aragon-Ching: Right.
Sam Chang: It captures the data from 70, 80% of the cancer centers, and this is what happens and this is where you go. What is your group's next project? What are you guys interested in looking at and why?
Jeanny Aragon-Ching: Yeah. I think the next project really would be, and there is a lot of interest really in the non-urothelial cancer cohorts, especially because, again, we see time and again, that they are the worst actors, poor prognosis group of patients. And I think developing strategies in order to help them as a whole would be really the next step, using this databases again, as you pointed out, Sam, as a real-world pattern so that we can further glean from this database so that we can apply it to our next generation of clinical trials.
Sam Chang: Last question then, what did you find out about urothelial cancers that you found interesting or unique or different? Because clearly just like you, and I think many others, we're looking at this non-urothelial, because we're trying to gain as much information from that as possible, because we don't have a lot of good information. Was there anything on the urothelial side that you found interesting, intriguing, maybe kind of fodder for the next trial, anything on the urothelial side?
Jeanny Aragon-Ching: Yeah. I do think there may be still a lot of room to evolve with this. So notice that our project actually encompass bladder and upper tract urothelial cancer. And even among urothelial cancers in the GU tract, I do think there is a difference between upper tract and bladder, even amongst the set of urothelial cancers. So I think that would be the next step to further dissect. We know in a lot of big databases, the adjuvant immunotherapy trials, the upper tract patients, even though they are urothelial, they behave differently. And I think that would be very important for us to tease out, because there definitely would be regular differences, behavioral differences, why they act differently or actually behave differently in terms of treatment as well.
Sam Chang: Well, Jeanny, thank you again for spending some time with us and really appreciate all the efforts that you've made. And obviously the folks at GU ASCO also wanted to show their appreciation as you presented it. So thanks again. And we look forward to future projects from your group.
Jeanny Aragon-Ching: Yeah. Thanks for having me here too.
Sam Chang: Absolutely.


NettyBlockRpcServer is a RpcHandler that handles messages for NettyBlockTransferService.
Enable TRACE logging level to see received messages in the logs.
Enable TRACE logging level for org.apache.spark.network.netty.NettyBlockRpcServer logger to see what happens inside.
When OpenBlocks arrives, NettyBlockRpcServer requests block data (from BlockDataManager) for every block id in the message. The block data is a collection of ManagedBuffer for every block id in the incoming message.
BlockDataManager is given when NettyBlockRpcServer is created.
NettyBlockRpcServer then registers a stream of ManagedBuffers (for the blocks) with the internal StreamManager under streamId.
The internal StreamManager is OneForOneStreamManager and is created when NettyBlockRpcServer is created.
In the end, NettyBlockRpcServer responds with a StreamHandle (with the streamId and the number of blocks). The response is serialized as a ByteBuffer.
When UploadBlock arrives, NettyBlockRpcServer deserializes the metadata of the input message to get the StorageLevel and ClassTag of the block being uploaded.
metadata is serialized before NettyBlockTransferService sends a UploadBlock message (using the internal JavaSerializer) that is given as serializer when NettyBlockRpcServer is created.
NettyBlockRpcServer creates a BlockId for the block id and requests the BlockDataManager to store the block.
The BlockDataManager is passed in when NettyBlockRpcServer is created.
In the end, NettyBlockRpcServer responds with a 0-capacity ByteBuffer.
UploadBlock is sent when NettyBlockTransferService uploads a block.
NettyBlockRpcServer initializes the internal registries and counters.
receive is part of RpcHandler Contract to…FIXME.


text:
Here's How Many Major US Cities Could Be Repopulated by Illegal Immigrants Who've Come Under Biden
So many illegal immigrants are coming into the United States on President Joe Biden's watch that they could repopulate some of the biggest American cities.
Biden is making some of the most paranoid fears about immigration seem less crazy.
In the first nine months of Biden's presidency, about 1.5 million migrants were caught illegally crossing the southern border — an influx nearly the size of Philadelphia, the sixth most populous U.S. city.
you've had the equivalent of the entire population of Philadelphia unlawfully migrate across the southern border, this calendar year alone. In 9 months, enough people to populate the 6th largest city in America, have been trafficked across the border by gangster rapist cartels… pic.twitter.com/62YrmjOiN8
— Aimee Terese (@aimeeterese) October 4, 2021
Between January and August 2021, U.S. Customs and Border Protection apprehended more than 1.3 million illegal immigrants at the southern border, according to the agency's data, with the rate breaking a 21-year monthly record in July.
In September, U.S.-Mexico border crossing appeared to be on pace to exceed 170,000 for a seventh consecutive month.
Former President Donald Trump kept illegal immigration at about a quarter of that level, with the exception of a surge in 2019.
Biden has faced some short-term factors outside his control, like natural disasters, COVID-19 and gang warfare, but his weakening of Trump's immigration policies appears to have made the border crisis much worse.
Last July, under Trump, 92% of the illegal immigrants caught at the southern border were expelled via "Remain in Mexico" and Title 42, and just 8% were released into the U.S. pending court dates.
This July, those numbers were 47% expelled and 53% released.
In the latest crisis, which saw some 15,000 Haitians arrive in Del Rio, Texas, about 2,500 of the migrants were sent back to Haiti, and 12,500, 83%, were let into the U.S.
The difference?: Biden canceled the "Remain in Mexico" policy, which requires migrants to wait outside the U.S. for their court dates, and he exempted minors from Title 42, which allows migrants to be turned away to prevent COVID-19 outbreaks.
"GREAT REPLACEMENT" FEARS
Fox News host Tucker Carlson, echoing others on the right, has alleged that Biden's immigration policies seek "the replacement of legacy Americans, with more obedient people from faraway countries" who will purportedly vote for Democrats.
Tucker Carlson Exposing The Point Of Biden's Border Crisis & Mass Immigration
"To change the racial mix of the country, that's the reason."
"In political terms, this policy is called the Great Replacement." pic.twitter.com/BfGGAY2p6X
— The Columbia Bugle 🇺🇸🍊 (@ColumbiaBugle) September 23, 2021
Even critics of Trump and the populist right have acknowledged that Biden is making Carlson's warnings seem more plausible to many Americans.
"You want to take the wind out of the racist 'Great Replacement' canard that appears to be gaining traction? You can huff and puff on Twitter, and feel great. Or you can get serious about border control," anti-Trump journalist Andrew Sullivan wrote on Substack last week.
"If mass migration continues to accelerate under this administration, and Biden seems unable or unwilling to do anything about it, Tump could win that election in a romp. And deserve to."


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