Are you looking for accommodation in Barcelona for a big group? Stop looking, you have found the ideal place! My Space Barcelona has groups of apartments located in the same buildings with swimming pools and terraces ideal for big groups. We have adequate accommodation for large number of people who want to stay altogether in the same space. Our group of apartments have capacity from 8 to 80 people, all staying in the same buildings and located in the city center of Barcelona.
If you are coming with your family to enjoy a nice time in Barcelona and you want to be all together but still want to enjoy the privacy of renting your own apartment we have the ideal alternatives for you and your family. If you are coming with a group of friends and want to stay altogether you can relax with them in one of our amazing swimming pools and terraces. If you are coming to Barcelona for business and need accommodation for your employees or colleagues we have the best locations for you and amazing apartments for groups of executives.
We also offer the best services to make your holiday a unique experience. You can enjoy the privacy of your group of apartments with all the benefits of a hotel such as: extra cleanings, transfer to and from the airport, tickets to the main attractions and museums in Barcelona and amazing tours to enjoy the best of the city.
Take a look at all our group of apartments and enjoy the best of Barcelona with My Space Barcelona!
This magnificent and modern building has 11 apartments and can allocate 88 people. It has a big shared swimming pool and most of the apartments have spectacular private terraces. The Gràcia neighbourhood is very close to the centre of Barcelona and walking through the streets gives an impression of being inside of a small Catalan village.
This impressive building has 11 apartments that share a great terrace and swimming pool with a lot of space. The main picture speaks for itself! 80 people can sleep in this building. It's ideal for large groups of workers or an entire family on holidays who want to get to know the real Barcelona. The neighbourhood, Gràcia, is our favourite in Barcelona. It's really a small town inside of a large city; the atmosphere is much different than in any other neighbourhood. When the sun comes out, people rests in the plazas and small streets, it looks like it has been taken out of a movie by Woody Allen.
Touristic building of apartments in Sarrià-Sant Gervasi, close to the best clinics, schools and universities of Barcelona.
Modern and exclusive building of touristic apartments with touristic license, located in one of the best areas of Barcelona: the exceptional neighbourhood of Sarrià-Sant Gervasi. It is known because of the many green parks, commercial areas, and exclusive boutiques, best Universities of Barcelona, the most well known Hospitals and Clinics of the city as well as a neighbourhood where the richest families of Barcelona live. The building has apartments with large terraces and balconies which make it perfect for groups of families, friends, executives, students or medical patients. In this building you can allocate up to 48 people in 7 different design apartments, very well located and close to the city centre.
This beautiful new building has 6 touristic apartments with license; each apartment has 3 bedrooms and 2 bathrooms and is located next to Arc de Triomf of Barcelona and the unbelievable Born quarter, both in the city centre, very well connected to all the points of interest of the city. Only a few minutes away by walk from Barceloneta beach. This building has an exquisite terrace in the rooftop with an awesome shared swimming pool. It's perfect to take a break with friends or family and enjoy the great views from the Eixample. The building can host up to 48 people.
Beautiful building of apartments that can host up to 40 people in 6 comfortable flats. Gràcia is a neighbourhood known for its bohemia and artistic atmosphere, singular bars, restaurants and beautiful and sunny squares. These apartments have amazing terraces, ideal to enjoy Barcelona with your family or friends. The city centre is only 15 minutes away by walk from this building. We also offer ideal services for customers who travel with children or babies.
We understand that work can be pretty stressful but your free time shouldn't be. That is why our goal is that your free time is not. By renting an executive apartment from My Space Barcelona you will get the best location and facilities you might need. We offer apartments with beautiful terraces, swimming pools, completely furnished and equipped so that your stay is as productive as possible.
Barcelona is, because of its safety and wide variety in offers, an amazing city to visit along your family. Exploring the Condal city and staying at a familiar apartment in Barcelona is a synonym of amusement. There are endless activities you can plan close to your apartment during your holidays: visiting Barcelona beaches, its numerous parks, the Zoo, Aquarium and much more! Every day in your touristic apartment will have a find and different activity for your family!
Barcelona offers high quality medical care of worldwide prestige, with clinics and hospitals in many different disciplines, such as renal transplantations, ocular surgery, thoracic, cardiac and plastic, likewise oncology and orthopaedics. My Space Barcelona will help you get the best and more comfortable accommodation possible so your recovery can be fast and easy.
Whether you are coming to Barcelona with your family, group of friends or even work colleagues, with My Space Barcelona you will find the best apartment in Barcelona with 2, 3 or 4 bedrooms for your stay. Booking an apartment in Barcelona with multiple bedrooms is ideal if you are looking for comfort and room to feel like home during your stay. If you are travelling with friends or family, choosing an apartment from 3 to 6 bedrooms is the best way to enjoy your stay in the Catalan city altogether.
Unbelievable apartments located in the core of Barcelona, Las Ramblas. Ideal for groups of up to 14 people in 2 classy apartments in one of the main streets of the city. Close to this apartments, you will find many of the main attractions of the city, such as La Pedrera, Casa Batlló, Plaça Catalunya and many more. Not many steps away from the building you will find the most exclusive restaurants and shops of the city. Don't miss the chance of enjoying Barcelona from inside.


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I kiiind of have wedding dresses on the brain.
since our little family excursion to NYC is creeping ever nearer, I've been trying to narrow down what I'm looking for in a wedding dress... as someone who loves clothes, it is proving more difficult than I thought!
I'm finding it far easier to explain what I DON'T want; no mermaid, no beading, no corsets, no ruching, no pick-ups, no train. but for what I do like... I'm kind of all over the place.
I LOVE off-the-shoulder. I like the idea of having some sort of straps... strapless just seems so overdone. and I love love love flowy-ness.
plus, my friend Janet told me it looked like a Belle dress a la Beauty and The Beast!
ignore the angry face and notice the pretty flower appliques! I'm not big on lace but this one is just so fairy-like. and I think I like empire waists.
this one is completely different... I love flowy, ethereal dresses, but I also love DETAIL. I want to look different and fun, and this dress definitely is. plus, it's tea-length so I could wear wicked shoes.
one of my key search words is certainly not simplicity (see previous pick!) but something about the neckline and the tulle of this dress really appeals to me. it might be a little old for me...but the neckline is fabulous.
a family favourite. my mom really likes this one (please forgive the bad photo, I originally saw it in a magazine and this is the best I could find online). again, off-the-shoulder, and I love the ruffled bottom.
so you see... I'm kind of going in two different directions. but I think things I'm looking for are fun, flowy, romantic, detailed, and different. that's about as far as I can get it narrowed down.
there are WAY more pictures I have saved, btw. I have cut up four magazines and prowled dozens of websites, including some that you can't steal pictures from. but I'm mostly just looking for an idea, or a feeling, of the type of dress I want.
...it's going to be one wild shopping day, haha.
once again, I'm back from a busy, internet-free week. I really should start doing that thing where you pre-set your posts for certain days... all in hindsight I guess!!
it was a week of sunshine, stress, and swimming pools. the sunshine and swimming definitely minimized the other. oh, and the hot tub. sa-weeet.
love love from a sleepy and sunnified girl.
who just realized Paul Rudd is in Clueless.
life is full of excitement.
we meet again, dear readers!
sorry for my long absence from bloggerland, but I've finally moved! things were insanely busy, with packing and moving and more packing and unpacking and I'm at my parents' with a TON of family visiting. it's kind of crazy but good. it's nice to just not do anything for a while. so while I apologize for abandoning you, dear readers.. I'm not that sorry, haha.
I'm in the process of compiling an entry for the chictopia remix contest (if I haven't missed the deadline already!) which I'm excited about! I don't really think I'll win- I've never won anything in my life haha- but I'm very interested in seeing the other entries.
so I thought for the other two I'd use it as a top and a skirt. this is remix #1; and my last photo shoot in Halifax. I won't be missing the staring neighbours!
one of the pros to buying this dress is that it also makes a great simple top; and a girl always needs a cute black top. it goes swell with my latest Modcloth purchase. what can I say, I can't resist rainbow forever! I like how the sleek top balances the busy bottom, especially with the popping red tights.
but the real stars of this outfit are the shoes! I've been wearing these babies like crazy the past month or so. they remind me of tap dancing shoes! and I love the little cut outs. perfect for colourful tights.
...halfway through this post I was called away for a back yard fire/marshmallow roast! this has been my life lately. I could certainly do worse. but I am now extremely tired, so I must leave you abruptly. things are going to be hectic for a while, but I have lots to tell you all!


Berliner, Emile, 1851-1929. Emile Berliner collection, 1871-1965.
Bob Hope collection, circa 1900-2009.
Brzezinski, Zbigniew, 1928-2017. Sound recordings and other material from the Zbigniew Brzezinski papers, circa 1979-2008.
Brzezinski, Zbigniew, 1928- Zbigniew Brzezinski papers.
Carlton E. Morse script collection, 1939-1952.
Columbia Records, Inc. Columbia Records paperwork collection, 1923-1964.
Columbia Records paperwork collection, 1923-1964.
DeMartino, Manfred F. Manfred F. DeMartino collection of CBS radio scripts, 1943-1945.
Eizenstat, Stuart. Oral history audiocassettes from the Stuart Eizenstat papers, 1979, 1989-2001.
H. Vose Greenough Jr. Collection, papers from the collection, 1937-1972.
Hope, Bob, 1903-2003. Bob Hope collection, circa 1900-2009.
Isabelle Sayers collection, papers from the collection, circa 1886-1980.
Jack Kapp collection, circa 1900-1949.
Jim Walsh collection, papers from the collection, 1867-1987, and undated.
John Peter collection, transcripts and photographs, 1951-1995.
John Secrist Jr. collection, papers from the collection, 1919-1973.
Joseph Nathan Kane collection, 1938-1939.
Kane, Joseph Nathan, 1899-2002. Joseph Nathan Kane collection, 1938-1939.
Kapp, Jack, 1901-1949. Jack Kapp collection, circa 1900-1949.
Kent, Joey. Louisiana hayride collection, 1904-2006.
Manfred F. DeMartino collection of CBS radio scripts, 1943-1945.
Mary Margaret McBride collection, photographs from the collection, 1934-1968, and undated.
McBride, Mary Margaret, 1899-1976. Photographs from the Mary Margaret McBride collection, 1934-1968, and undated.
Morse, Carlton E., 1901-1993. Carlton E. Morse script collection, 1939-1952.
National Broadcasting Company history files, 1922-1986.
National Broadcasting Company. National Broadcasting Company history files, 1922-1986.
Papers from the H. Vose Greenough Jr. collection, 1937-1972.
Papers from the H.V. Greenough collection, 1937-1972.
Papers from the Isabelle Sayers collection, circa 1886-1980.
Papers from the Jim Walsh collection, 1867-1987, and undated.
Papers from the John Secrist Jr. collection, 1919-1973.
Peter, John, 1917-1998. Transcripts and photographs from the John Peter collection, 1951-1995.
Photographs from the Mary Margaret McBride collection, 1934-1968, and undated.
Prescott, Allen. Allen Prescott collection, 1930-1968.
Record industry publicity collection, 1937-1979.
Sayers, Isabelle S. Papers from the Isabelle Sayers collection, circa 1886-1980.
Schwartz, Tony. Tony Schwartz collection, 1912-2008.
Secrist, John, 1918-1958. Papers from the John Secrist Jr. collection, 1919-1973.
Seeley, Frank, 1917-2001. Frank Seeley collection, 1973-01-20--1973-03-26.
Smith, Joe, 1928- Joe Smith collection, 1986-1988.
Sound recordings and other material from the Zbigniew Brzezinski papers, circa 1979-2008.
Stuart Eizenstat papers, oral history audiocassettes from the Stuart Eizenstat papers, 1979, 1989-2001.
Transcripts and photographs from the John Peter collection, 1951-1995.
Walsh, Jim, 1903-1990. Papers from the Jim Walsh collection, 1867-1987, and undated.
Zbigniew Brzezinski papers, sound recordings and other material from the papers, circa 1979-2008.


text:
Terry Meyer
Independent Talent Management Consultant
Terry Meyer is an independent consultant, academic, author and presenter.
He has a Masters of Management Degree from Wits Business School.
His areas of expertise include strategy and organisational design, leadership and leadership development, change facilitation and human capital strategy with a specific emphasis on talent management and leadership development.
As a Consultant of 20 years' experience he works at Executive levels facilitating solutions to organisational problems. His more recent consulting experience has involved:
Facilitating the business strategy of medium and large organisations
Facilitating the restructuring of a variety of organisations at Executive level and below
Building a leadership strategy for organisations, including leadership succession and development
Developing talent strategies for organisations to ensure a future pipeline to deliver the strategy of the business
Undertaking a comprehensive diagnosis of organisational effectiveness and propose appropriate change strategies
Assist organisations build a human capital strategy and framework and reposition their human resources function to improve effectiveness
Advising organisations on building a learning academy to improve the effectiveness of their skills development strategy
He has recently been appointed to the Global OD Faculty of Barclays Plc. to assist in the leadership development and culture change in that organisation.
On the Academic front, Terry was a full time Faculty member of Wits Business School for 8 years where he taught organisational behaviour and was responsible for the highly regarded Master of Management in HR Programme.
He is currently Programme Director for the HR Executive Leadership Programme run by Stellenbosch Business School and which he was responsible for designing.
He also runs the Wits Business School International Executive L&D Study Tour where he leads a number of senior HR and L&D professionals to engage with top global companies and Business Schools in the US and Europe.
He previously lectured on the UNISA SBL Executive Development Programme.
While at Wits he won an award for the best academic article in a local academic journal.
As an author he has written or co-edited 6 important books and has contributed articles to a number of journals.
His books include:
Meyer, T 1996 Competencies: Creating Competitive Advantage, Knowledge Resources
Meyer & Boninelli, 2004 Conversations in Leadership: South African Perspectives, Knowledge Resources
Boninelli & Meyer, 2004, Building Human Capital: South African Perspectives, Knowledge Resources (NB: This is currently being revised)
Babb & Meyer, 2005, Perspectives in Learnerships, Knowledge Resources
Boninelli & Meyer, 2011, Human Capital Trends, Knowledge Resources
Meyer, T 2012 Strategy, Leadership and Change: A Practical Guide for Busy Executives, Knowledge Resources
As a presenter he has spoken at a number of top conferences and regularly runs public and in house training programs in his fields of expertise.
He has played a leadership role as a professional. He was a Board member of the IPM on two occasions and was instrumental in facilitating the turnaround strategy of the IPM in 2007 and 8. He is registered as a Master HR Professional with the SABPP.
He has received a number of professional awards, including the IPM Presidential Award in 2008, an award at the International HRD Congress in Mumbai in 2009 and a Lifetime Achievement Award from the SABPP in 2012.
Terry has the ability to blend extensive academic thought leadership with his practical experience in a corporate role and as a consultant. He is considered a leading thinker and advisor in his various fields of expertise. His primary theoretical basis is grounded in systems thinking and he has the ability to approach organizational problem solving from a multi-disciplinary perspective.

redpajama_set_name: RedPajamaCommonCrawl


text:
package com.facebook.infrastructure.net.io;

import java.net.InetSocketAddress;
import java.nio.ByteBuffer;
import java.nio.channels.FileChannel;
import java.nio.channels.SocketChannel;
import java.io.*;

import org.apache.log4j.Logger;
import org.apache.commons.lang.ArrayUtils;

import com.facebook.infrastructure.db.Table;
/**
 * Author : Avinash Lakshman ( alakshman@facebook.com) & Prashant Malik ( pmalik@facebook.com )
 */

class ContentStreamState extends StartState
{
    private static Logger logger_ = Logger.getLogger(ContentStreamState.class);
    private static long count_ = 64*1024*1024;
    /* Return this byte array to exit event loop */
    private static byte[] bytes_ = new byte[1];
    private long bytesRead_ = 0L;
    private FileChannel fc_;
    private StreamContextManager.StreamContext streamContext_;
    private StreamContextManager.StreamStatus streamStatus_;

    ContentStreamState(TcpReader stream)
    {
        super(stream);
        SocketChannel socketChannel = stream.getStream();
        InetSocketAddress remoteAddress = (InetSocketAddress)socketChannel.socket().getRemoteSocketAddress();
        String remoteHost = remoteAddress.getHostName();
        streamContext_ = StreamContextManager.getStreamContext(remoteHost);
        streamStatus_ = StreamContextManager.getStreamStatus(remoteHost);
    }

    private void createFileChannel() throws IOException
    {
        if ( fc_ == null )
        {
            logger_.debug("Creating file for " + streamContext_.getTargetFile());
            FileOutputStream fos = new FileOutputStream( streamContext_.getTargetFile(), true );
            fc_ = fos.getChannel();
        }
    }

    public byte[] read() throws IOException, ReadNotCompleteException
    {
        SocketChannel socketChannel = stream_.getStream();
        InetSocketAddress remoteAddress = (InetSocketAddress)socketChannel.socket().getRemoteSocketAddress();
        String remoteHost = remoteAddress.getHostName();
        createFileChannel();
        if ( streamContext_ != null )
        {
            try
            {
                bytesRead_ += fc_.transferFrom(socketChannel, bytesRead_, ContentStreamState.count_);
                if ( bytesRead_ != streamContext_.getExpectedBytes() )
                    throw new ReadNotCompleteException("Specified number of bytes have not been read from the Socket Channel");
            }
            catch ( IOException ex )
            {
                /* Ask the source node to re-stream this file. */
                streamStatus_.setAction(StreamContextManager.StreamCompletionAction.STREAM);
                handleStreamCompletion(remoteHost);
                /* Delete the orphaned file. */
                File file = new File(streamContext_.getTargetFile());
                file.delete();
                throw ex;
            }
            if ( bytesRead_ == streamContext_.getExpectedBytes() )
            {
                logger_.debug("Removing stream context " + streamContext_);
                handleStreamCompletion(remoteHost);
                bytesRead_ = 0L;
                fc_.close();
                morphState();
            }
        }

        return ArrayUtils.EMPTY_BYTE_ARRAY;
    }

    private void handleStreamCompletion(String remoteHost) throws IOException
    {
        /*
         * Streaming is complete. If all the data that has to be received inform the sender via
         * the stream completion callback so that the source may perform the requisite cleanup.
        */
        IStreamComplete streamComplete = StreamContextManager.getStreamCompletionHandler(remoteHost);
        if ( streamComplete != null )
        {
            streamComplete.onStreamCompletion(remoteHost, streamContext_, streamStatus_);
        }
    }

    public void morphState() throws IOException
    {
        /* We instantiate an array of size 1 so that we can exit the event loop of the read. */
        StartState nextState = stream_.getSocketState(TcpReader.TcpReaderState.DONE);
        if ( nextState == null )
        {
            nextState = new DoneState(stream_, ContentStreamState.bytes_);
            stream_.putSocketState( TcpReader.TcpReaderState.DONE, nextState );
        }
        else
        {
            nextState.setContextData(ContentStreamState.bytes_);
        }
        stream_.morphState( nextState );
    }

    public void setContextData(Object data)
    {
        throw new UnsupportedOperationException("This method is not supported in the ContentStreamState");
    }
}

redpajama_set_name: RedPajamaGithub


This week we are starting a new segment where we will highlight a favorite resort or hotel. For our fist Hotel Spotlight segment, we are showcasing the newly renovated Hilton Playa del Carmen. Read on for everything you need to know about this stunning property!
The Hilton Playa del Carmen has been re-branded from the former The Royal Playa del Carmen. If you stayed at The Royal Playa del Carmen in the past, you can expect the same gorgeous property but with Hilton's unprecedented level of service. This is a great option for groups or couples because it is exclusively for adults.
To make this property even more luxurious, Hilton completely renovated their rooms and suites. Check out the photos below!
Hilton Playa del Carmen can expect a multitude of luxuries when they book an all-inclusive stay. You'll find 7 restaurants, 5 bars and lounges, and 24-hour in-suite dining. Dining options include oceanfront dining, a tequileria and cigar club, and tons of different cuisines.
There are also tons of different suite options to choose from. You'll find swim-up suites and beachfront walkout suites. In addition, each and every suite above ground level has its own private balcony and double jetted tub.
Hilton Playa del Carmen also offers an abundance of activities for it's guests, including gorgeous pools and beaches with drink and food service, a fully equipped fitness center, introductory scuba lessons, cooking demonstrations and tequila tastings, Zumba and other dance classes, non-motorized water sports, and live nightly entertainment.
Location, location, location! This is a great property for those who want to venture off property for nightlife, restaurants and bars, or shopping. Located just steps from Playa del Carmen's famous Fifth Avenue, Hilton Playa del Carmen brings you the best of both worlds. With all-inclusive luxury, restaurants, bars, pools, and beach on property and adventure and more on Fifth Ave, you'll never get bored here. This unique property will keep you occupied both on the resort and off! Plan a group getaway for an adventurous crew here, or a romantic getaway to explore the hidden gems of Fifth Avenue. Whatever you decide, you're sure to have an amazing experience.
If you are not familiar with Playa del Carmen's amazing 5th Avenue, you're in for a treat. Called "Quinta" by locals, this pedestrian street runs parallel to the beach and has a ton of options for shopping, dining, and entertainment. The most popular and busy area runs from Calle 3 sur (south 3rd street) to 40th Street. It includes about 22 blocks of shopping and dining options.
Starting on the south end, you'll begin at Paseo Del Carmen shopping plaza. This shaded area offers mostly clothing and souvenir shops. Once you past Paseo Del Carmen, you can skip the area between this and Calle 1 Sur as it is very cheap and tacky. Once you make it to Calle 1 Sur, the area between this street and Juarez Avenue is known as Parque Fundadores. This is a really exciting area and a great place for families, with a kids play area. There is even handicap beach access here. In addition, you'll find papantla dancers throughout the day and Mayan dancers once sun sets. Be sure to check out the little white church on the corner of Parque Fundadores. It is a historic site and you will see it used on Sunday mornings. You can even attend a service here if you wish.
If you are looking for American brands and shopping opportunities, head to the intersection of 12th Street where you will find Calle Corazon shopping mall. You'll find stores like H&M, Sephora, and more. 12th Street also has a lot to offer in the way of nightlife. The night clubs and bars stay open here until 5 AM!
Contact us today to book your own stay at Hilton Playa del Carmen. You can reach us at 402-390-9291 or get started here.


Daytona State College's Marketing and Communications Department supports the college mission of open access and student success by communicating the excellence of programs, initiatives and services of the college through electronic and print media, advertising and photography, and working with news outlets.
Daytona State's Marketing and Communications Department contributes to student success by supporting and promoting the programs and services of the college. The team is responsible for creating and implementing a coordinated and comprehensive image of the college through electronic and print communications, advertising, publications, photography and special events.


FUSIO have extensive experience in the provision of high quality mobile services and applications. We have built mobile-enabled websites for several of our clients, and have extensive experience of developing mobile applications, such as alerts and interactive SMS applications.
For examples of our work check out the range of mobile apps and mobile sites that we have developed.
If your website does not render correctly for mobile phone browsers, you should seriously consider contacting FUSIO to help adapt your site to attract the growing population of web savvy users that search, browse, book and buy services and products from their mobile phones.


After double-digit growth a year earlier, Turkey's market for agricultural and forestry machinery hits a brake, increasing by 6% as Turkish farmers struggle with low prices, a slowing food processing sector, and a major slowdown in agricultural export activities. After Turkey's failed coup attempt in July 2016, foreign direct investments into food processing sector dip by 54% . Russian trade sanctions make significant contribution to trade slowdown, as Russia's share of agricultural exports dips 10 percentage points in 2016. Affected by slow market growth, income of agricultural machinery also slows, rising by 6% . Industry expected to see 8% CAGR over 2016-2021, driven by growing mechanisation in agricultural sector, continuing land consolidation, and new government incentives to modernise Turkish farms.
This Euromonitor industrial report provides unique data and analysis of Agricultural and Forestry Machinery in Turkey: ISIC 2921. With this industrial report, you'll be able to explore in detail the entire industry from its sources of supply to its buyers.


text:
Author Interviews, Cancer Research, Dermatology, Melanoma, Vitamin C / 10.01.2023
Finnish Study Finds Fewer Melanoma Cases Among Regular Users of Vitamin D
MedicalResearch.com Editors' note: Please consult your health care provider before initiating any vitamin supplementation, including Vitamin D as potentially serious side effects are possible. MedicalResearch.com Interview with: Prof. Ilkka T Harvima Department of Dermatology University of Eastern Finland and Kuopio University Hospital Kuopio, Finland MedicalResearch.com: What is the background for this study? Response: The North Savo Skin Cancer Program in Eastern Finland was launched in 2017, and it aims at reducing the incidence, morbidity and mortality caused by skin cancers, such as basal cell carcinoma, squamous cell carcinoma and melanoma. A part of this program constituted a follow-up project of patients with an assessed risk of skin cancer. There are also several other parts, such as analysis of skin cancer material reposited in the Biobank of Eastern Finland (see the enclosed BMC Cancer 2021 reference), public information, education of general physicians and medical students etc. In 2021, we published the article in BMC Cancer (enclosed), where we attempted to clarify the reasons for the relatively high melanoma mortality in relation to its incidence in this region (North Savo) of the country. By using the biobank material we also published an article in 2022 showing that melanoma and melanoma in situ associate with keratinocytic premalignant lesions and keratinocyte skin carcinomas (Suhonen V, Siiskonen H, Suni M, Rummukainen J, Mannermaa A, Harvima IT. Malignant and in situ subtypes of melanoma are associated with basal and squamous cell carcinoma and its precancerous lesions. Eur J Dermatol 2022 Apr 1;32(2):187-194. doi: 10.1684/ejd.2022.4221.). The follow-up study of about 500 subjects is ongoing (COVID-19 caused pretty much trouble for the recruitment). This is focused on finding risk factors and biomarkers for skin cancers and carcinogenesis. The first study on these follow-up patients was published in 2021 (Komulainen J, Siiskonen H, Harvima IT. Association of elevated serum tryptase with cutaneous photodamage and skin cancers. Int Arch Allergy Immunol 2021;182(11):1135-1142. doi: 10.1159/000517287.). The article on vitamin D just recently published in Melanoma Research on Dec 28, 2022, is the second one. The third work in pipeline deals with the association of atopic disorders with skin cancers, and the manuscript is under revision. So, these provide with some background for the article in Melanoma Research. Actually, we thought that vitamin D use might associate with skin photoaging, actinic keratoses and carcinogenesis, but the only, though very important, finding was its association with melanoma. We have not focused our research just on vitamin D only, but it looks like we need to go further. (more…)
Author Interviews, Dermatology / 21.12.2022
The Latest Trends in Psoriasis Research
Autoimmune skin conditions like Psoriasis...
Author Interviews, Dermatology, Lancet / 13.12.2022
Atopic Dermatitis- Eczema: New Antibody Therapy Has Potential to Modify Disease Course
MedicalResearch.com Interview with: Dr. Emma Guttman-Yassky, MD, PhD Waldman Professor and System Chair The Kimberly and Eric J. Waldman Department of Dermatology Director, Center of Excellence in Eczema Director, Laboratory of Inflammatory Skin Diseases Icahn School of Medicine at Mount Sinai MedicalResearch.com: What is the background for this study? What are the main findings? Response: The background for this study are studies that show that OX40 is a pathway that is upregulated in patients with atopic dermatitis (or eczema). OX40 is involved in activation of immune molecules associated with allergy and atopy, and also with formation of memory immune cells that are required for disease recurrence. The hypothesis to the study was that giving an OX40 antagonist will not only ameliorate the disease but perhaps have a remittive effect in that the disease will not come back. Indeed all drug doses were significantly effective at week 16, the primary endpoint compared to placebo and continued to improve towards week 36, the secondary endpoint. In addition, the responders to treatment maintained their responses for an additional 20 weeks, which is unusual, suggesting a potential for disease modification. (more…)
Aging, Author Interviews, Brigham & Women's - Harvard, Dermatology, Heart Disease, Herpes Viruses, Stroke / 23.11.2022
Herpes Zoster: Persistent Increased Risk of Cardiac Event or Stroke After Shingles
MedicalResearch.com Interview with:| Sharon G. Curhan, MD, ScM| Director, CHEARS: The Conservation of Hearing Study Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston, MA 02114 MedicalResearch.com: What is the background for this study? Response: Herpes zoster, commonly known as "shingles," is a viral infection that often causes a painful rash. Shingles can occur anywhere on the head or body. Shingles is caused by the varicella zoster virus (VZV), the same virus that causes chickenpox. After a person has chickenpox, the virus stays in their body for the rest of their life. Years and even decades later, the virus may reactivate as shingles. Almost all individuals age 50 years and older in the US have been infected with the varicella zoster virus and therefore they are at risk for shingles. About 1 in 3 people will develop shingles during their lifetime, and since age is a risk factor for shingles, this number may increase as the population ages. The risk is also higher among individuals of any age who are immunocompromised due to disease or treatment. A number of serious complications can occur when a person develops shingles, such as post-herpetic neuralgia (long-lasting pain), but there was limited information on whether there are other adverse long-term health implications of developing shingles. There is a growing body of evidence that links VZV, the virus that causes shingles, to vascular disease. VZV vasculopathy may cause damage to blood vessels and increase the risk of stroke or coronary heart disease. Although some previous studies showed a higher risk of stroke or heart attack around the time of the shingles infection, it was not known whether this higher risk persisted in the long term. Therefore, the question we aimed to address in this study was to investigate whether shingles is associated with higher long-term risk of stroke or coronary heart disease. To address this question, we conducted a prospective longitudinal study in 3 large US cohorts of >200,000 women and men, the Nurses' Health Study (>79,000 women), the Nurses' Health Study II (almost 94,000 women) and the Health Professionals Follow-Up Study (>31,000 men), without a prior history of stroke or coronary heart disease. We collected information on shingles, stroke and coronary heart disease on biennial questionnaires and confirmed the diagnoses with medical record review. We followed the participants for up to 16 years and evaluated whether those who had developed shingles were at higher risk for stroke or coronary heart disease years after the shingles episode. The outcomes we measured were incident stroke, incident coronary heart disease [defined as having a non-fatal or fatal myocardial infarction (heart attack) or a coronary revascularization procedure (CABG, coronary artery bypass graft or percutaneous transluminal coronary angioplasty)]. We also evaluated a combined outcome of cardiovascular disease, which included either stroke or coronary heart disease, whichever came first. (more…)
Makeup Applied to Facial Features Improves Perceived Skin Evenness
MedicalResearch.com Interview with: Carlota Batres, Ph.D.
Assistant Professor, Department of Psychology
Director, Preferences Lab PreferencesLab.com
Franklin and Marshall College MedicalResearch.com: What is the background for this study? Response: Previous research has found that complexion-oriented makeup products, such as foundation and concealer, make the skin appear more even. Interestingly, though, the effect size of perceptual judgements has been found to be larger than the effect size of physical measurements, suggesting that there are factors affecting the perception of skin evenness that are not captured by the physical measurements of isolated skin patches. (more…)
Dermatology, Lifestyle & Health / 28.10.2022
Science-Backed Health Benefits Of Medical Spa Treatments
A recent scientific study found that Botox injections can help reduce the symptoms of mental health conditions like anxiety and depression, according to a report on Euronews. As more people seek non-invasive treatments to achieve beautiful, youthful, and natural looks, market experts predict that the medical spa industry will continue to grow. Currently, medspa therapies range from loose RNA that stimulates regeneration of skin to hydrafacials, microneedling, body sculpting, and laser hair removal. And while many people are embracing these medspa treatments, there are major concerns about their effectiveness. Keep reading to learn the science-backed health benefits of medical spa treatments. (more…)
Author Interviews, Cancer Research, Dermatology, Race/Ethnic Diversity / 18.10.2022
Hair Straightening Chemicals May Increase Uterine Cancer Risk
MedicalResearch.com Interview with: Alexandra J. White, PhD, MSPH Stadtman Investigator Epidemiology Branch National Institute of Environmental Health Sciences National Institutes of Health Research Triangle Park, NC MedicalResearch.com: What is the background for this study? What is the chemical primarily used in hair straighteners? Response: Hair products such as dye and chemical straighteners contain several different chemicals that may act as carcinogens or endocrine disruptors and thus may be important for cancer risk. Straighteners in particular have been found to include chemicals such as phthalates, parabens, cyclosiloxanes and metals and may release formaldehyde when heated. Previous research has suggested that hair dye and chemical straighteners are related to other hormone-sensitive cancers such as breast and ovarian cancer, but no previous study has considered how they are related to uterine cancer risk. (more…)
Author Interviews, Dermatology, Immunotherapy, NEJM, University of Pittsburgh / 06.10.2022
NEJM: Trial of IVIG for Autoimmune Disorder Dermatomyositis
MedicalResearch.com Interview with: Rohit Aggarwal, MD, MS Rheumatology, Professor of Medicine Medical Director, Arthritis and Autoimmunity Center Sub-Specialty Education Coordinator Division of Rheumatology Department of Medicine University of Pittsburgh MedicalResearch.com: What is the background for this study? Response: Dermatomyositis is a rare autoimmune inflammatory disease that affects muscles and skin, although muscular forms without skin symptoms and vice versa are also seen. The exact etiology of the disease is not known but is thought to be immune-mediated with many patients having highly specific autoantibodies. There is no cure for dermatomyositis, but several types of treatment have been successfully used in the last years including different kinds of immunosuppressants (e.g. steroids) and intravenous immune globulins (IVIG) to improve the patient's condition. So far, none of these treatments was approved for use in dermatomyositis based on large, randomized, placebo-controlled trials. Their effectiveness was mainly deduced from clinical experience and from small clinical trials. The ProDERM study was the first large, pivotal, randomized placebo-controlled trial to evaluate the efficacy and safety of intravenous immune globulin (IVIG) in dermatomyositis patients. (more…)
Author Interviews, Cancer Research, Dermatology, Melanoma / 22.09.2022
Melanoma: Tel-Aviv University Study Finds Blocking Two Key Proteins May Block Brain Metastases
MedicalResearch.com Interview with: "Prof. Ronit Satchi-Fainaro, the Director of the Cancer Biology Research Center led this study with an outstanding PhD student, Sabina Pozzi" Prof. Ronit Satchi-Fainaro, Ph.D. Head, Cancer Research and Nanomedicine Laboratory Kurt and Herman Lion Chair in Nanosciences and Nanotechnologies Director, Cancer Biology Research Center Department of Physiology and Pharmacology Sackler Faculty of Medicine Sagol School of Neuroscience Tel Aviv University, Tel Aviv 69978, Israel MedicalResearch.com: What is the background for this study? Response: Cutaneous melanoma is the deadliest of all skin cancers, especially due to its tendency to invade and develop metastases with an incidence of brain metastasis development of 40% to 50% in patients with melanoma stage IV (although the incidence post mortem is 70–90%). We know that the brain microenvironment represents the first line of reaction in favor or against the tumor due to its dual ability to generate an immune-stimulatory or immunosuppressive niche, which will ultimately determine the establishment and growth of melanoma brain metastasis. Among the brain-resident cells, astrocytes are responsible for the maintenance of the brain homeostasis, and subsequent to melanoma brain colonization, they sustain and foster the growth of melanoma cells (more…)
Author Interviews, Cost of Health Care, Dermatology, JAMA / 08.09.2022
Private Equity and Health Care: More Patients, More Charges
MedicalResearch.com Interview with: Jane M. Zhu, M.D., M.P.P., M.S.H.P. Assistant Professor of Medicine Division of General Internal Medicine and Geriatrics School of Medicine Oregon Health & Science University Portland, Oregon MedicalResearch.com: What is the background for this study? Response: Private equity (PE) acquisitions of physician practices are accelerating across many specialties, but there is still little robust evidence on the effects of these acquisitions. Concerns about PE involvement is predicated on the fact that these firms expect high annual returns, which require either reducing costs or increasing revenue, or both. Using PE acquisition data from 2016-2020, linked to commercial claims data, we sought to understand what common mechanisms of revenue generation were being adopted after private equity acquisition of physician practices. (more…)
Author Interviews, Dermatology, Infections / 15.07.2022
Dermatology Researchers Test First Topical Gel for Treatment of Molluscum Contagiosum
MedicalResearch.com Interview with: Dr Dilip Kachhawa, MD Department of Skin & Venereal Disease Dr Sampurnanand Medical College Jodhpur, Rajasthan, India MedicalResearch.com: What are the main findings? Response: Molluscum Contagiosum (MC) is an infection caused by molluscipoxvirus. It is difficult to study since the virus only survives in human skin, and therefore there isn't an animal or cell model to study potential treatments. Molluscum lesions appear as raised, domed shaped skin-colored lesions and can occur anywhere on the body but are most common on the face, neck, arms, legs, and abdomen. Sometimes there are few lesions, but clusters of several lesions can appear. Children are the most likely to get molluscum, and the virus is highly contagious, transmitted by direct contact with infected skin or contaminated objects, like towels, linens and toys. Scratching can cause autoinoculation which is when a person reinfects themself. MC is very common, impacting an estimated 6 million adults and mostly children in the US each year. In 2010, there was an estimated 122 million cases worldwide. It occurs primarily in humid and warm climates, and transmission via swimming pools and bathtubs may be possible. Therefore, molluscum is often called "water warts." Many physicians may take a "watch and wait" approach since the virus may clear on its own. However, it can take months to up to 5 years for some to experience complete clearance, In the meantime, the person is still highly contagious and may spread the virus to others, particularly children. Lesions can be bothersome, causing itching and sometimes a secondary infection. There is also a psychosocial component. In a recent study, 1 in 10 children with molluscum experienced a major quality of life issue. Berdazimer Gel, 10.3% is a potential first-in-class topical controlled-nitric oxide releasing medication containing Berdazimer (sodium), a new chemical entity, and the active ingredient in berdazimer gel 10.3%. The mechanism of action of berdazimer in the treatment of molluscum is unknown, but in vitro lab studies show that the nitric oxide, released when berdazimer is combined with a hydrogel, may impede viral replication and perhaps help body's natural immune response against molluscum. (more…)
Hair Loss: Sexual Dysfunction Signal Linked To Finasteride Use Young Men
MedicalResearch.com Interview with: Naeem Bhojani, MD, FRCSC Division of Urology, Centre Hospitalier de l'Université de Montréal (CHUM), University of Montréal, Montréal, Québec, Canada David-Dan Nguyen MPH Division of Urological Surgery and Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsFaculty of Medicine and Health Sciences, McGill University, Montréal, Québec, Canada MedicalResearch.com: What is the background for this study? Response: In a recent study by our group published in JAMA Dermatology (https://jamanetwork.com/journals/jamadermatology/fullarticle/2772818), finasteride use was found to be associated with increased reporting of suicidality and depression in young patients with androgenetic alopecia. This previous analysis suggested that the association between finasteride and depression might be mediated by sexual dysfunction. Building on this work, we conducted this second analysis to examine the association between finasteride use and reports of sexual dysfunction. (more…)
Author Interviews, Dermatology, Race/Ethnic Diversity / 28.04.2022
Tinted Sunscreens: Consumer Preferences Based on Light, Medium, and Dark Skin Tones
MedicalResearch.com Interview with: Dr. Neelam Vashi MD Director of the Boston University Center for Ethnic Skin Dermatologist at Boston Medical Center, and Dr. Henriette De La Garza MD Research fellow Boston University School of Medicine MedicalResearch.com: What is the background for this study? Response: The COVID-19 pandemic abruptly shifted many of our daily activities to an online world, dramatically increasing the use of electronic devices. Although visible light exposure from screens is small compared with the amount of exposure from the sun, there is concern about the long-term effects of excessive screen time. Recent studies have demonstrated that exposure to light emitted from electronic devices, even for as little as 1 hour, may cause reactive oxygen species generation, apoptosis, collagen degradation, and necrosis of skin cells. Visible light increases tyrosinase activity and induces immediate erythema in light-skinned individuals and long-lasting pigmentation in dark-skinned individuals. In recent years, tinted sunscreens have been rising in popularity because they are an effective and convenient way to protect against high-energy visible light while providing cosmetic benefits. The purpose of this analysis was to study current available options and product factors that may influence consumer preference when choosing a tinted sunscreen so dermatologists can improve their familiarity with available products and tailor their recommendations to patients with all skin tones. (more…)
Author Interviews, Dermatology, JAMA, Melanoma, University of Pittsburgh / 08.04.2022
Melanoma: Screened Patients More Likely to be Diagnosed with Thin Tumors
MedicalResearch.com Interview with: Laura Ferris, M.D., Ph.D. Professor of Dermatology Director of clinical trials for UPMC Department of Dermatology University of Pittsburgh School of Medicine MedicalResearch.com: What is the background for this study? Response: In this quality initiative at UPMC (a large academic and community health system in Western PA and surrounding areas) Primary Care Physicians were trained to perform annual skin cancer screening examinations of their patients who were aged 35 years and older at routine medical visits. Over a 5-year period more than 595,000 patients who were eligible to be screened were seen by a UPMC PCP and about 24% of them were screened. We compared the number and thickness (an important indicator of prognosis) of the melanomas diagnosed in those patients who were screened to those who were not screened. (more…)
Author Interviews, Dermatology, Yale / 08.04.2022
JAK Inhibitors Show Promise For Treatment of Severe Alopecia Areata
Brett King, MD, PhD, FAAD Associate Professor of Dermatology Yale School of Medicine MedicalResearch.com: What is the background for this study? Response: Alopecia areata is an autoimmune disorder marked by disfiguring, non-scarring hair loss, and there are no therapies approved by the U.S. Food and Drug Administration for treatment of the disease. JAK inhibitors are showing promise for treatment of severe alopecia areata. In this work, the pooled results of two phase 3 clinical trials of the JAK inhibitor baricitinib were reported out to 52 weeks. (more…)
Abuse and Neglect, Author Interviews, Dermatology, JAMA, Pediatrics / 27.03.2022
Atopic Dermatitis and Growth Parameters in Children
MedicalResearch.com Interview with: Aaron Drucker MD, ScM, FRCPC Division of Dermatology, Department of Medicine, Women's College Hospital Scientist, Women's College Research Institute Assistant Professor, Department of Medicin and Institute of Health Policy, Management and Evaluation University of Toronto Adjunct Scientist, ICES MedicalResearch.com: What is the background for this study? What are the main findings? Response: Because atopic dermatitis is a chronic condition that is common in children, parents and physicians often wonder if it will affect overall child well-being, including their growth parameters. Previous studies were mostly cross-sectional, so we conducted a longitudinal study to follow children over time. We found that although young children with atopic dermatitis were somewhat shorter with higher BMI than children without atopic dermatitis, these differences were small and attenuated as children grew older. (more…)
Author Interviews, Dermatology, Diabetes / 22.02.2022
Leg Wounds: Topical Timolol Accelerated Healing Times in Elderly Patients
MedicalResearch.com Interview with: Chih-Shan Jason Chen, MD, PhD Director, Dermatologic and Mohs Micrographic Surgery Unit Memorial Sloan Kettering Skin Cancer Center at Hauppauge Attending Mohs Surgeon, Dermatology Service Memorial Sloan Kettering Cancer Center Chief, Dermatologic Surgery Northport VA Medical Center Associate Professor of Clinical Dermatology Renaissance School of Medicine at Stony Brook University MedicalResearch.com: What is the background for this study? Response: Managing a surgical wound on the lower leg can be a challenge. Often, higher wound tension, atrophic skin, edema, and compromised circulation result in higher risks of wound dehiscence and infection, and significantly limit the capacity of wound closure post-surgically. Therefore, healing by secondary intention is a practical option for many lower leg Mohs defects. However, a secondary intention wound on the lower leg is expected to take a longer time to heal. Certain factors such as older age and health conditions of the host may adversely affect healing time. Timolol is a nonselective beta-adrenergic receptor antagonist that has FDA approval for the treatment of glaucoma. In addition to this FDA-approved indication, topical timolol has several off-label uses in dermatology, such as for the treatment of infantile hemangiomas, venous stasis ulcers, and refractory wounds. Although timolol solution has been used in chronic wounds, knowledges of the efficacy and utility of timolol in an acute post-surgical wound setting is lacking. (more…)
Dermatology / 21.02.2022
Why The Water Content Level in Your Skin Matters
The body contains around 60%...
Author Interviews, Dermatology, Emory, JAMA, Race/Ethnic Diversity / 27.01.2022
Differences in Sun-Protective Behaviors Among Asian American Subgroups
MedicalResearch.com Interview with: Howa Yeung, MD MSc | He/him/his Assistant Professor of Dermatology Emory University School of Medicine Atlanta, GA 30322 MedicalResearch.com: What is the background for this study? Response: Asian Americans are the fastest growing racial group in the United States but are underrepresented in health research. Existing research often categorize Asian Americans into a single racial category, which may mask differences in health behaviors and outcomes subgroups. We sought to examine potential differences in skin cancer-related risk factors and screening among Asian Americans in a large, nationally representative study. (more…)
Allergies, Author Interviews, COVID -19 Coronavirus, Dermatology, UCSF / 27.11.2021
'Hypoallergenic' Hand Sanitizers Often Contain Common Allergens
MedicalResearch.com Interview with: Carina M. Woodruff, MD Department of Dermatolog University of California, San Francisco MedicalResearch.com: What is the background for this study? What are the main findings? Response: Rigorous hand hygiene has been an important component of the CDC's COVID-19 guidelines. With millions of Americans now using hand sanitizers regularly, we are seeing many more cases of hand dermatitis. Our study evaluated the key product features and most common allergens in the top-reviewed, commercial hand sanitizers sold by major US retailers. We found that the most common potential allergens were tocopherol, fragrance, propylene glycol and phenoxyethanol. Our study also showed that nearly 1 in 5 marketing claims on these products was misleading. For example, 70% of sanitizers with the marketing claim "hypoallergenic" included at least one common allergen in its formulation. (more…)
Author Interviews, Cancer Research, Dermatology, Lancet, Melanoma, Technology / 11.11.2021
Dermatology: Datasets Used for AI Lack Diversity and Completeness
MedicalResearch.com Interview with: Dr David Wen BM BCh NIHR Academic Clinical Fellow in Dermatology University of Oxford MedicalResearch.com: What is the background for this study? Response: Publicly available skin image datasets are commonly used to develop machine learning (ML) algorithms for skin cancer diagnosis. These datasets are often utilised as they circumvent many of the barriers associated with large scale skin lesion image acquisition. Furthermore, publicly available datasets can be used as a benchmark for direct comparison of algorithm performance. Dataset and image metadata provide information about the disease and population upon which the algorithm was trained or validated on. This is important to know because machine learning algorithms heavily depend on the data used to train them; algorithms used for skin lesion classification frequently underperform when tested on independent datasets to which they were trained on. Detailing dataset composition is essential for extrapolating assumptions of generalisability of algorithm performance to other populations. At the time this review was conducted, the total number of publicly available datasets globally and their respective content had not previously been characterised. Therefore, we aimed to identify publicly available skin image datasets used to develop ML algorithms for skin cancer diagnosis, to categorise their data access requirements, and to systematically evaluate their characteristics including associated metadata. (more…)
Author Interviews, COVID -19 Coronavirus, Dermatology, Respiratory / 06.10.2021
Study Evaluates Risk of Respiratory Infections, Including COVID-19, In Psoriasis Patients on Biologics
MedicalResearch.com Interview with: Lara van der Schoot MD, PhD candidate Department of Dermatology Radboud University Medical Center Nijmegen, The Netherlands MedicalResearch.com: What is the background for this study? Response: Psoriasis is a chronic, immune mediated skin disease for which effective targeted biological agents have become available the past years. Inherent to their immunomodulatory mechanism of action, biologics might increase infections risk. We know from clinical trial data that respiratory tract infections are among the most common adverse events during biologic treatment, but real-world data is sparse. Regarding the risk of serious infections among biologic users, mostly defined as infections requiring hospitalization, previous studies provided different results and there is limited comparative data for the newer biologics available. The COVID-19 pandemic turned attention to the risk of infections among biologic users, especially for respiratory tract infections, as they might relate to susceptibility for viral respiratory tract infections such as COVID-19. In our study, the primary aim was to determine the risk of respiratory tract infections among real-world psoriasis patients treated with biologics, including the newer IL-17 and IL-23 inhibitors. The secondary aim was to assess risk of serious infections in this cohort. Additionally, rates of SARS-CoV-2 infections were assessed. (more…)
Mt. Sinai Researchers Explore Polycomb Induced Skin Pigmentation, Without UV Light
MedicalResearch.com Interview with: Elena Ezhkova, PhD Professor, Department of Cell, Developmental, and Regenerative Biology Professsor, Dermatology Lab Head,The Black Family Stem Cell Institute Icahn School of Medicine at Mount Sinai New York Meng-Yen Li, PhD Postdoctoral Fellow The Black Family Stem Cell Institute MedicalResearch.com: What is the background for this study? Response: The epidermis is the primary barrier and the first line of defense to combat environmental stressors. The sun's ultraviolet (UV) is one of the main environmental stressors that our body is exposed to daily. UV produces DNA damage in epidermal cells and is a leading cause of skin cancers. To protect from the damaging effects of UV, epidermal cells become pigmented by melanocytes, pigment-producing cells. Taken up by epidermal cells, the melanin pigment absorbs UV light and reduces DNA damage. How the epidermis senses UV and how it leads to epidermal pigmentation is poorly understood. (more…)
Aging, Author Interviews, Cancer Research, Dermatology, Frailty, JAMA / 08.09.2021
Basal Cell Skin Cancer: Watchful Waiting Better for Some Frail, Elderly Patients
MedicalResearch.com Interview with: Marieke van Winden MD MSc PhD candidate Dermatology Radboud Institute for Health Sciences Department of Dermatology Radboud University Medical Center Nijmegen, the Netherlands MedicalResearch.com: What is the background for this study? What underlying conditions would factor in a decision for Watchful Waiting? Response: Basal cell carcinomas are frequently treated because of the risk for progression, which can cause a significant morbidity due to local tissue invasion and destruction. However, most BCCs are characterized by a relatively indolent nature, growing slowly and frequently asymptomatically. Because patients with a limited life expectancy might not live long enough to develop symptoms from basal cell carcinoma progression, they might not live long enough to benefit from treatment. Underlying conditions that determine life expectancy should therefore be considered when weighing BCC management options. When life expectancy is expected to be relatively short, and the consequences of watchful waiting (WW) are relatively low risk (low tumor burden expected within the remaining lifespan), WW should be considered. (more…)
Author Interviews, Dermatology, JAMA, Race/Ethnic Diversity / 16.08.2021
Skin Disease Hidradenitis More Commonly Afflicts Black Patients
MedicalResearch.com Interview with: Joerg Albrecht, MD, PhD Dermatologist, Internist, Clinical Pharmacologist Division of Dermatology, Department of Medicine Attending Dermatologist, Chair Division of Dermatology Chair system-wide Pharmacy & Therapeutics Committee Cook County Health Chicago, IL 60612 MedicalResearch.com: What is the background for this study? Response: The study was stimulated by data that suggested that an unusually large proportion of inpatient with Hidradenitis suppurativa (HS) were African American. HS is an underdiagnosed disease and the total numbers of inpatients with HS in the year we looked at initially seemed small. So we wanted to test whether this finding held up when the period of observation was extended. Point estimates can be unreliable and we had followed another finding in the data that did not hold up when we looked at other years, so we felt one year was not enough to confirm a trend (more…)
Alzheimer's - Dementia, Author Interviews, Dermatology / 15.08.2021
Skin Cells May Provide Biomarker for Frontotemporal Dementia Diagnosis
MedicalResearch.com Interview with: Annakaisa Haapasalo, PhD Adjunct Professor Research Director (Associate Professor A.I. Virtanen Institute for Molecular Sciences Molecular Neurodegeneration University of Eastern Finland | UEF | MedicalResearch.com: What is the background for this study? At what age might these changes be present? Response: Our research team is interested in understanding the underlying disease mechanisms and developing biomarkers for frontotemporal dementia (FTD). FTD is the second most common cause of dementia in the working age population. Presently, no efficient therapies exist for FTD, it is challenging to diagnose, and the disease mechanisms of different types of FTD remain largely unclear. We are especially interested in FTD associated with the C9orf72 repeat expansion because it is the most common genetic cause of frontotemporal dementia and exceptionally prevalent in Finnish FTD patients. Many current studies of FTD and C9orf72 repeat expansion have largely concentrated on examining neurons, as these are the principle CNS cells that are affected in neurodegeneration. Neurons are also one of our key research interests, but obtaining neurons directly from living patients is difficult in many ways. Therefore, we became interested in exploring the FTD patient skin fibroblasts with the idea in mind that they might represent more easily accessible patient-derived cells than neurons for trying to decipher disease mechanisms of FTD. Moreover, we were interested in finding out if these cells show any specific alterations or deficiencies that could be utilized later on in biomarker studies or testing drug effects. (more…)
Author Interviews, Dermatology, Geriatrics, Sleep Disorders / 07.08.2021
Geriatric Patients with Atopic Dermatitis Can Suffer From Sleep Disturbances
MedicalResearch.com Interview with: Dr. Jonathan L. Silverberg MD PhD MPH Associate Professor Director of Clinical Research Director of Patch Testing George Washington University School of Medicine and Health Sciences Washington, DC MedicalResearch.com: What is the background for this study? Response: Atopic dermatitis affects people of all ages, including geriatric patients. Previous studies found age-related differences in the clinical manifestations of atopic dermatitis between children and adults. Though, few studies examined whether there are age-related differences of AD severity between geriatric and younger adults. We performed a cross-sectional real-world observational study and found that geriatric age (≥65 years) was not associated with atopic dermatitis severity. However, geriatric age was associated with increased sleep disturbances, delays falling asleep and nighttime awakenings from itch, as well as fatigue. (more…)
Author Interviews, Cancer Research, Dermatology, NEJM / 20.07.2021
KLISYRI® (tirbanibulin): Shorter Topical Treatment for Common Precancerous Actinic Keratoses
MedicalResearch.com Interview with: Jane Fang, MD Clinical Athenex, Inc. MedicalResearch.com: What is the background for this study? Response: Tirbanibulin is a first-in-class synthetic molecule that has potent anti-proliferative activity by inhibiting tubulin polymerization and disrupting src kinase signaling. It has been formulated as an ointment for the treatment of actinic keratosis, a very common precancerous condition of UV-damaged skin that affects over 50 million people in the US. The most commonly adopted management approach is to remove AK lesions as it is hard to predict which lesion will become cancerous. Lesion-directed treatment like cryotherapy can effectively remove lesions one at a time but does not treat larger field of cancerization. Also, it is limited by associated pain and long term complication such as scarring. Currently approved topical treatments involve cumbersome application courses of weeks or months, and induce considerable local skin reactions that were not well tolerated by patients. The Phase 3 studies demonstrated that a short 5-day once daily course of tirbanibulin ointment 1% is an efficacious and safe topical treatment of actinic keratosis. (more…)
EU Discusses Increasing Prevention of Melanoma and Non-Melanoma Skin Cancer
Professor Marie-Aleth Richard EADV Communications Committee Chair Professor, University Hospital of La Timone Marseille, France MedicalResearch.com: What is the background for this Roundtable event? Would you describe the mission of the European Commission's Beating Cancer Plan? Response: Europe's Beating Cancer Plan is the first, comprehensive EU strategy on cancer, aimed at tackling the disease through all key stages: prevention; early detection; diagnosis and treatment; and quality of life of cancer patients and survivors. The Plan also aims to create opportunities to improve cancer care through research and innovative projects, such as artificial intelligence, and to promote equal access to knowledge and treatments in cancer care across Europe. The EADV seeks to create a bridge between the EU health policy agenda and scientific research, by engaging with policymakers, patient organisations and other stakeholders to support a patient centric-approach; tackling melanoma and non-melanoma skin cancers (NMSC) at all stages of the pathway, from prevention to follow-up care. Through our Roundtable event, the EADV brought together these key stakeholders to evaluate the effectiveness of the EBCP on preventing both melanoma and NMSC, as well as identify joint recommendations that step-up measures towards this goal. (more…)
Author Interviews, Dermatology, PNAS / 01.06.2021
Itch Signals Transmitted Differently in Hairy vs Non-Hairy Skin
MedicalResearch.com Interview with: Haley Steele Graduate Student Researcher Georgia Institute of Technology MedicalResearch.com: What is the background for this study? Response: Chronic itch is a debilitating symptom that arises from a broad range of etiologies including skin disease, systemic disease, and as a common side-effect of medication. While in the last few decades significant advances in our understanding of the mechanisms underlying chronic itch have been made, a large majority of those advancements were restricted to studies in hairy skin. Conditions such as plantar and palmar psoriasis, dyshidrosis, and cholestasis, however, are known to exhibit chronic itch restricted primarily to glabrous skin (found on the palms of hands and soles of feet). This is an area that is considered to be particularly debilitating. Therefore, in this study we investigated the role three previously identified pruriceptive neurons (MrgprA3+, MrgprD+, and MrgprC11+) play in mediating acute and chronic glabrous skin itch. (more…)


Description: Blingsting WWW.BLINGSTING.COM Pepper Spray is our core (and first) product, which launched about one year ago. This summer, we wlll introduce new designs and also a new personal safety alarm. Blingsting is designed to clip to the outside of a purse, backpack, leash or on keys, so that it's accessible when and if a girl actually needs it. And of course, it's sparkly. We are re-shaping the way that girls think and feel about personal safety products. Traditionally, this is a very 'boring' space filled with boring products that are found in obscure places like gun shops and hardware stores. The main players in the personal safety /self-defense industry have never taken the approach we are taking, and it's working! We believe in sparkly, practical, quality products placed in high-end retail packaging and a real focus on branding that incorporates pop-culture, humor, and style.


text:
ACCEPTED

#### According to
The Catalogue of Life, 3rd January 2011

#### Published in
Willdenowia, Beih. 7: 103 (1972)

#### Original name
Athelia nivea Jülich, 1972

### Remarks
null