text:
Notre équipe clinique
Maladies inflammatoires systémiques
Maladies allergiques
Immunodéficiences
Suivi des transplantés d'organes
Laboratoire de diagnostic
Système Qualité
Pré-analytique
Médicaments biologiques
Hépatites virales
HLA & transplantation
Autoimmunité
Gammapathies
Immunité cellulaire
Site WEB du Département des laboratoires
Service de diagnostic HIV
Traductions LIA
Maladies immunologiques
Notre offre de formation
Formation prégraduée
Formation postgraduée
Thèmes 2020
Main scientific focus areas
Anti-viral immunity
CD8 T cell responses
HIV specific CD4+ T cell responses
Basic HIV research
Antigen variation
Neuroimmunology
Characterization of TBC specific T cell responses
Development of new TBC diagnosis tools
Vaccine design and development
Pre-clinical HIV Vaccine development
Role of adenovirus
Shorts CV
Vaccine and Immunotherapy Center
What is a clinical trial ?
How to get involved ?
Community Advisory Board - CAB
Our team / Notre Equipe
Clinical immune-monitoring platform
Lab Meetings 2020
Un vaccin contre le VIH?
d'immunologie et allergie
Maladies Maladies inflammatoires systémiques Maladies allergiques Immunodéficiences Suivi des transplantés d'organes
Laboratoire de diagnostic Nouveautés Informations Archives Site WEB du Département des laboratoires Service de diagnostic HIV Formulaires de demande d'analyses Liens utiles Traductions LIA
Notre offre de formation Formation prégraduée Formation postgraduée
Formation continue Thèmes 2020 Thèmes 2019 Thèmes 2018 Thèmes 2017 Thèmes 2016 Thèmes 2015 Thèmes 2014 Thèmes 2013
Main scientific focus areas Anti-viral immunity Autoimmunity Basic HIV research Neuroimmunology Transplantation Primary Immunodeficiency Tuberculosis Vaccine design and development Shorts CV
Vaccine and Immunotherapy Center About us What is a clinical trial ? How to get involved ? Ongoing studies Past studies Community Advisory Board - CAB Our team / Notre Equipe
Présentation du Service Un vaccin contre le VIH?
Primary immunodeficiency (PID) is a term used to indicate disorders of the immune system that are genetically determined. PIDs are a group of rare and heterogeneous diseases that can affect all arms of the immune system and generally present with infection patterns unusual for severity, frequency, anatomical distribution and/or involved organisms. Other frequent clinical features of PIDs are susceptibility to autoimmune diseases, autoinflammatory syndromes and malignancy.
About 300 forms of PID are currently known the study of which represent unique opportunities to unravel the mechanisms underlying development, differentiation and function of the immune system.
Defining the molecular basis of PIDs
While many forms of PIDs have clinical presentations that are pathognomonic, in many cases different disease have overlapping and common clinical features. In addition, atypical presentations of well-known syndromes often complicate the clinical interpretation. Establishing a definitive genetic diagnosis is of paramount importance to make prognostic assessments and to provide adequate clinical management and genetic counseling to affected patients and families. The revolution of genomic analysis brought about by the development of high-throughput, next generation sequencing (NGS) methods has allowed tremendous progress in identifying mutations that cause undiagnosed childhood genetic diseases. It is now therefore possible to apply NGS platforms to the screening of genes responsible for known forms of PIDs, as well as of candidate genomic regions that may be implicated in the pathophysiology of still undefined immunologic defects.
We have established a platform for targeted gene sequencing of a library of >360 genes that are either known to be causing PID phenotypes or that have known associations with biological pathways implicated by genes that are known to be causing PID phenotypes. Genomic DNA of patients with clinical suspicion of PID will be analyzed using this approach and deleterious genomic sequences identified and characterized. To this aim our laboratory performs:
1. Studies in patient-derived primary immune cells.
Several immune system cell types (e.g. lymphocytes, dendritic cells) can be maintained in culture for relatively long period of time, which allows for characterization of functional defects in vitro. Examples of such functional assays are cell proliferation and cytokine production tests, cytotoxic and podosome formation assays, etc.1-12
2. Studies in patient-derived immortalized cell lines.
When possible and relevant, lymphocyte cell lines will be established through immortalization mediated by Epstein-Barr virus for B lymphocytes and saimiri virus or HTLV-1 for T lymphocytes.3,4,13-15
3. Studies in patient-derived primary progenitor cells.
Several in vitro differentiation systems are available that can be utilized to generate cell types that may be present in the patient's circulation in small numbers or to analyze the differentiation steps that may be affected by the specific genetic defects. To these aims, hematopoietic progenitors cells obtained from patients are induced to differentiate into mature T, B, NK and myeloid cells in vitro.16-18
4. Studies in patient-derived induced pluripotent stem cells (iPSc).
Access to patient's primary hematopoietic progenitors can be challenging. Generation of patient-derived iPSCs from patient dermal fibroblasts overcomes this potential problem. Fibroblasts will be reprogrammed into iPSCs through the temporary expression of OCT4, SOX2, KLF4 and cMYC, and differentiated into embryoid bodies that, in turn, will be used in the lympho-hematopoietic differentiation systems described above.
5. Modeling specific gene mutations by gene editing.
We will supplement the above-described studies with the generation of model systems based on healthy control cells in which the original variants detected in patient samples will be introduced by gene editing using zinc-finger nucleases and the CRISPR/Cas-9 system.19 Target cells types will include primary lymphocytes, hematopoietic progenitors (e.g. CD34+ bone marrow, cord blood or peripheral blood mobilized progenitors), and iPS cells.
Role of the Wiskott-Aldrich Syndrome Protein in the Differentiation and Regulation of the Immune System
The proposed research project plans to investigate the role of the Wiskott-Aldrich Syndrome protein (WASp) in the mechanisms that underlie the differentiation of the normal immune system and the maintenance of tolerance. Our experimental plan builds on prior observations from our group and demonstrating that both mice and humans with affected expression of WASp have important phenotypic and functional deficiencies within several key cellular components of the immune system (e.g. natural regulatory T cells - Treg, immature and mature B lymphocytes) that results in immunodeficiency, immune dysregulation and development signs and symptoms of autoimmunity.5,7-9,11-12,20-27 This project aims at expanding our studies to other critical aspects of immune system regulation such as the generation of peripherally induced regulatory T cells (iTreg), Treg cell-derived effector T lymphocytes (Ex-Treg cells), marginal zone (MZB) and follicular B cells, as well as follicular helper T lymphocytes (Tfh cells). Based on the current knowledge of the immunological role of WASp and our own published data, we have formulated the following main hypotheses:
1. WASp has a cell-intrinsic role in the function of FoxP3-expressing, regulatory T cells;
2. Wasp plays a role in the differentiation of MZB cells at the BCR and/or Notch2 signal level.
3. Wasp plays a role in the germinal center tolerance checkpoint in GC B cells and/or Tfh cells.
To test these hypotheses, we will pursue the following primary objectives:
a) To characterize a mouse model of regulatory T cell-specific WASp deficiency by performing T and B cell suppression assays, study the effects of the absence of WASp in the generation of iTregs, define the effects of Wasp-defective Tregs in the occurrence of peripheral autoreactive B cells, and investigate the effects of the absence of WASp on the the generation of effector Ex-Treg cells.
b) To assess the role of WASp in the BCR and NOTCH signal-dependent MZB cell differentiation and maintenance steps in inducible B cell conditional Was knock-out mice.
c) Assess the role of WASp in peripheral naïve B cell tolerance and GC B cell selection.
d) Assess the susceptibility to induced and spontaneous autoimmunity of mice carrying WASp deficient Tfh cells.
The results deriving from this proposal will advance our understanding of the mechanisms underlying the differentiation of the normal immune system, the maintenance of tolerance and have the potential to lead to the development of novel therapeutics for autoimmune diseases.
This research project investigates the role of the Wiskott-Aldrich Syndrome protein (WASp) in the immunological mechanisms that are responsible for maintenance of tolerance. Genetic deficiency of WASp expression in humans results in a clinical syndrome including thrombocytopenia, hemorrhages, eczema, recurrent infections, cancer, and autoimmunity. The latter complication can affect 40% to 70% of the patients and its occurrence has been associated with increased susceptibility to malignancies and poor overall prognosis.
Prior observations from our group demonstrated that both mice and humans with defective or absent expression of WASp have important functional deficiencies among critical tolerance inducing immune cells, such natural regulatory T cells (nTreg) 5,9 and develop signs and symptoms of autoimmunity 11,20. Our current research aims at expanding our investigations to other critical aspects of immune system regulation such as the generation of peripherally induced regulatory T cells (iTreg), generation and function of regulatory B cells (Breg) and transcriptional regulation of Th1 differentiation. Based on the current knowledge of the immunological role of WASp, our own published and preliminary data, we have formulated the following main hypotheses:
WASp plays a role in the differentiation of naïve T cells into tolerogenic regulatory T cells;
Mutations affecting WASp function interfere with the generation and/or function of IL-10-producing regulatory B cells;
The Th1-inducing transcriptional activity of WASp can be uncoupled from its ARP2/3-dependent cytosolic role in in vivo models of WASp deficiency.
To test these hypotheses, we are pursuing the following objectives:
Assess the role of WASp in peripheral Treg induction by comparing WASp-deficient and control naïve T cells for Foxp3 induction (in vitro and in vivo) and generation of functional iTreg cells.
Assess the presence and function of CD19+ CD1dhigh CD5+ B cells in Was-/- mice and IL-10-producing CD24high CD38high B lymphocytes in WAS patients.
Generate and characterize the immune phenotype of lymphocytes expressing mutated forms of WASp either lacking the NLS, NES, or VCA domains using iPSCs and genetically targeted mouse models.
The results deriving from this proposal will advance our understanding of the molecular bases of the immunological mechanism maintaining tolerance and have the potential to lead to the development of novel therapeutics for autoimmune diseases.
1 Otsu, M. et al. Lymphoid development and function in X-linked severe combined immunodeficiency mice after stem cell gene therapy. Mol Ther1, 145-153 (2000).
2 Wada, T. et al. Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism. Proc Natl Acad Sci U S A98, 8697-8702 (2001).
3 Wada, T., Jagadeesh, G. J., Nelson, D. L. & Candotti, F. Retrovirus-mediated WASP gene transfer corrects Wiskott-Aldrich syndrome T-cell dysfunction. Hum Gene Ther13, 1039-1046 (2002).
4 Bosticardo, M. et al. Retroviral-mediated gene transfer restores IL-12 and IL-23 signaling pathways in T cells from IL-12 receptor beta1-deficient patients. Mol Ther9, 895-901 (2004).
5 Adriani, M. et al. Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol124, 41-48 (2007).
6 Davis, B. R. et al. Somatic mosaicism in the Wiskott-Aldrich syndrome: molecular and functional characterization of genotypic revertants. Clin Immunol135, 72-83 (2010).
7 Nikolov, N. P. et al. Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein. Blood116, 740-747 (2010).
8 Taylor, M. D. et al. Nuclear role of WASp in the pathogenesis of dysregulated TH1 immunity in human Wiskott-Aldrich syndrome. Sci Transl Med2, 37ra44 (2010).
9 Adriani, M. et al. Defective inhibition of B-cell proliferation by Wiskott-Aldrich syndrome protein-deficient regulatory T cells. Blood117, 6608-6611 (2011).
10 Lawrence, M. G. et al. Elevated IgE and atopy in patients treated for early-onset ADA-SCID. J Allergy Clin Immunol (2013).
11 Shimizu, M. et al. Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J Allergy Clin Immunol131, 587-590 e581-583 (2013).
12 Simon, K. L. et al. Molecular and phenotypic abnormalities of B lymphocytes in patients with Wiskott-Aldrich syndrome. J Allergy Clin Immunol133, 896-899 e894 (2014).
13 Candotti, F. et al. Retroviral-mediated gene correction for X-linked severe combined immunodeficiency. Blood87, 3097-3102 (1996).
14 Candotti, F. et al. In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction. J Exp Med183, 2687-2692 (1996).
15 Candotti, F. et al. Retrovirus-mediated WASP gene transfer corrects defective actin polymerization in B cell lines from Wiskott-Aldrich syndrome patients carrying 'null' mutations. Gene Ther6, 1170-1174 (1999).
16 Haddad, R. et al. Dynamics of thymus-colonizing cells during human development. Immunity24, 217-230 (2006).
17 La Motte-Mohs, R. N., Herer, E. & Zuniga-Pflucker, J. C. Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro. Blood105 (2005).
18 Lagresle-Peyrou, C. et al. Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nat Genet41, 106-111 (2009).
19 Peterson, L. et al. Comparison of Gene Editing Strategies for Gene Correction of Wiskott-Aldrich Syndrome in Mouse Embryonic Stem Cells. Mol. Ther.22, S216-S217 (2014).
20 Shimizu, M. et al. Development of IgA nephropathy-like glomerulonephritis associated with Wiskott-Aldrich syndrome protein deficiency. Clin Immunol142, 160-166 (2012).
21 Recher, M., et al., B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood119, 2819-2828 (2012).
22 Crestani, E., et al., Broad spectrum of autoantibodies in patients with Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J Allergy Clin Immunol136, 1401-1404 (2015).
23 Kolhatkar, N.S., et al., Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome. J Exp Med212, 1663-1677 (2015).
24 Pala, F., et al., Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients. J Clin Invest125, 3941-3951 (2015).
25 Yokoyama, T., et al., Age-Dependent Defects of Regulatory B Cells in Wiskott-Aldrich Syndrome Gene Knockout Mice. PLoS One 10, e0139729 (2015).
26 Volpi, S., et al., N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome. Blood 127, 216-220 (2016).
27 Lexmond, W.S., et al., FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J Clin Invest 126, 4030-4044 (2016).
Service d'immunologie et allergie
BH10-527


China Doll song lyrics are the property of the respective artist, authors and labels, they are intended solely for educational purposes and private study only. The chords provided are my interpretation and their accuracy is not guaranteed.
China Doll lyrics and chords are here for your personal use, this is an extraordinary Slim Whitman song. You can learn to pick and sing this country classic with these lyrics and chords.
The first time my wife heard Slim Whitman sing this wonderful song she wanted to add it to her music book. If you don't have it in your music library, order one of Slim's CDs that includes this classic on the play list. Print China Doll lyrics and chords, practice a bit and then enjoy the pleasures of classic country music.


This is a chic black Haori with diamond, pair bird, "Kiri" (paulownia) and 'Kiku'(chrysanthemum) design, which is embroidered.
Gold foil threads are added to the design partly.
It has slight frays on back embroidery.
It has slight patinas, discoloration and stains on the lining.


The new Octaspring® Hybrid Plus™ mattress is a perfect way to experience unique Octaspring® technology, combined with the conventional feel of pocket springs, a perfect hybrid of modern and traditional.
he new Octaspring® Hybrid Plus™ mattress is a perfect way to experience unique Octaspring® technology, combined with the conventional feel of pocket springs, a perfect hybrid of modern and traditional.
The new Octaspring® HYBRID™ mattress is a perfect way to experience unique Octaspring technology, combined with the conventional feel of pocket springs.


text:
Chorwacja wystawia reprezentację kobiet na mistrzostwa Europy w curlingu od 2005, do 2009 grała w grupie B, od 2010 w grupie C. Łącznie w reprezentacji wystąpiło 19 zawodniczek.

Wyniki

Reprezentacja

Mecze

Curling w Chorwacji
Chorwacja, kobiety
Curling

redpajama_set_name: RedPajamaWikipedia


-Brief biography of your musical project, no longer than one page in length. Keep it concise and to the point and avoid using fluff words.
-8 x 10 hi resolution promotional photo of the artist/band, something that could be used in printing flyers, posters, and the like.
-Three or four song demo, showcasing your best recorded material to date. You are only as good as your latest release.
-Fact sheet of music industry, press, radio, and show accomplishments. This basically acts as your professional resume for journalists and music venue bookers to refer to.
-Press page with selected quotes and reviews of your live show and studio albums. +Looking for Press Contacts?
-Radio page, containing all of the radio stations that have and are currently spinning your latest release. +Looking for Radio Contacts?
-Shows page explaining where and when you have played and where you are currently booked. This must include city and state listings when pursuing an out of state venue for bookings. +Looking for Music Venues and Booking Contacts?


text:
CODE 911: Alleged prowler leaves getaway car
Sun | Local
Lynette Meachum — Dec 8th, 2000
CENTRAL KITSAP - Deputies arrested a 15-year-old boy after his mother helped them find stolen stereo parts in the trunk of her car Wednesday, according to a Kitsap County sheriff's report.
A resident of Olympic Village Apartments spotted a car prowl happening in the parking lot and called 911 as the two alleged perpetrators, both in ski masks, ran away, the report said.
Deputies found a CD player and amplifier missing from the car, and began to check other cars in the lot to see if they had also been robbed.
One car had its door open, the keys in the ignition and a ski mask lying on the seat, the report said.
They called the car's registered owner, who told them her car was missing and so was her son, the report said. She came to the scene and unlocked the trunk for them.
Inside were the stolen items, along with another stereo system.
The mother later called deputies when her son arrived home. He told them he stole the stereos because he needed money, the report said.
CODE 911: Family says armed intruder has stalked them from California
POULSBO - A 14-year-old Poulsbo boy called Kitsap County sheriff's deputies Sunday to report an armed burglar in his mobile home. The boy said he was drawing a bath when he saw a man, dressed all in black and armed with a Bowie ... [Read More...]
CODE 911: Girlfriend allegedly threatened
NAVY YARD CITY - A man suspected of slitting a California man's throat allegedly threatened to give his girlfriend the same treatment Sunday morning. According to a Kitsap County sheriff's report, the couple was arguing outside the C&C Supersave on G ... [Read More...]
CODE 911: Suspected check thief drives off with car
BREMERTON - A woman reported her car stolen Thursday after a friend drove it away and left her at the store where he allegedly had just forged a stolen check. The man purchased some clothes at the Fred Meyer store on Highway 303 with ... [Read More...]
Man holes up in car for five hours
A domestic violence incident turned into a nearly six-hour ordeal with sheriff's deputies early Thursday, according to the Kitsap County Sheriff's Office. An Indianola woman called 911 Wednesday night to report that an ex-boyfriend was at her door with a gun tucked into his ... [Read More...]
CODE 911: In-law problems
CENTRAL KITSAP - A 37-year-old man and his 71-year-old father-in-law were both arrested Friday after several domestic disputes. The young couple was living in a motor home on North Ridge Lane, while the older man was staying on the same property in a ... [Read More...]

redpajama_set_name: RedPajamaCommonCrawl


In this paper we present a specific example of the current state-of-the-art in desktop image access in the GI section of the Department of Radiology at the Hospital of the University of Pennsylvania. We describe a system which allows physicians to view and manipulate images from a Philips digital fluoroscopy system at the workstations in their offices. Typically they manipulate and view these images on their desktop Macs and then submit the results for slide making or save the images in digital teaching files. In addition to a discussion of the current state-of-the-art here at HUP, we also discuss some future directions that we are pursuing.


text:
package org.usfirst.frc.team4453.robot.commands;

import org.usfirst.frc.team4453.robot.Robot;

import edu.wpi.first.wpilibj.command.InstantCommand;

/**
 *
 */
public class notUsed_TiltReset extends InstantCommand {

	public notUsed_TiltReset() {
		requires(Robot.shooter);
		setInterruptible(false);
	}

	@Override
	protected void initialize() {
		System.out.println("TiltReset");
	}

	@Override
	protected void execute() {
		Robot.shooter.tiltLower();
	}

	@Override
	protected void end() {
	}

	@Override
	protected void interrupted() {
		Robot.shooter.tiltStop();
	}
}

redpajama_set_name: RedPajamaGithub


Psalm 1:1-6. This sermon was preached by Pastor Marty Bonner on January 6, 2019.
As we begin this New Year, we begin by praying for our walk with God. We need His wisdom and guidance for the path ahead of us, and we need to grow in our ability to follow Him. However, more than these things from the Lord, we need His presence in our life. So we come to the question. Am I walking with God as I should? Am I following the One that He sent, the Lord Jesus Christ? This is a question that we can ask ourselves every day. It is that important.
The Bible presents Jesus as the perfect Son of God. He is our example of how to walk with God the Father. Yes, He is definitely more than an example, but He is one nonetheless, which we would do well to follow.
Our passage today compares and contrasts the one who refuses to walk with the world, and walks with God, to the one who does not. This is not about disconnecting from society and the people around us in order to go on a spiritual journey. Rather, it is living our life in the midst of society and the people around us by following God's direction and not our own. It is recognizing that my way provides no salvation for myself or this world, but His way brings life.
We need to learn to walk with the Lord.
Verse one of this psalm opens with a series of statements that use the verbs "walk, stand, and sit." It is clear that the psalmist is not just thinking of the simple actions in and of themselves. He is not worried that a sinner might walk beside him on the road to Jerusalem, or that a scoffer might happen to sit by him at a wedding. Rather, he uses these verbs as extensions of the choices that we make in our heart and in our mind, which cause us to do these things in league with certain people.
Thus, it is not about who happens to be walking next to me, but who I choose to walk with. Similarly it is not about who happens to be standing or sitting beside me, but about those whom I choose to stand with and sit beside because I share their purpose and outlook on life. We need to learn to choose to walk in harmony with the Lord, to walk in fellowship with Him, and to walk by His leading.
Thus we end up with a list of things that we should avoid because they take us away from the Lord. As we look at this list, we should also note how Jesus perfectly demonstrates how to avoid them. First, the blessed man chooses not to listen to the counsel of the wicked. Now, the wicked are those who reject God's Word and do what they want. They have chosen a path that is adverse to God's path for mankind. Those who reject God's path, and consequently His fellowship, have their own way of looking at things and their own "wisdom." Their counsel or advice is always a twisted reasoning why they should not follow the counsel of the Lord. Their counsel is like that of the devil's when he tempted Eve. "Has God really said…" The wicked can be openly hostile to God, or they may operate under the umbrella of God's people. Yet, their counsel always provides an exit off of the path of God's way. If we are to do well this year, we must learn to avoid listening to the counsel of the wicked.
Second, the blessed man chooses not to stand on the path of sinners. "Sinners" here is a conceptual rhyme with the earlier "wicked." They are essentially the same with a slight difference in nuance. Yet, the emphasis moves from their counsel to their path. We start walking away from the Lord by first listening to their counsel, but then we find ourselves walking their same path. The sinner's path is not the path of the Lord. The very definition of the word sinner is one who misses or falls short of God will. They go a different way than the Lord. Again, if we are to do well this year, we must not go down the path of those who reject God's counsel and are refusing to walk with Him.
Third, the blessed man chooses not to sit in the seat of scoffers. The image of a seat seems to be the end of a series of choices that lead to a worse and worse situation spiritually. Having listened to false counsel, and walking down a false path, we can end up in a destination full of those who scoff, mock, and scorn those who follow God. How sad to go from walking with God to mocking those who still do so. If you find yourself sitting with those who mock and deride God and His Word, if you find yourself in league with such people and such attitudes, then you are in a bad place. If we are to do well this year, we will need to avoid that mocking spirit which wants to pull us off of the path of Christ and on to a path of our own making.
Now verse 2 gives us the positive things that a blessed person embraces. Here we see that the first is the Law of the Lord. Now the psalmist is an Israelite living prior to the times of Christ and the Law of the Lord represented the apex of God's Word. God had made a covenant with Israel and given them His Law. As Christians we are not under the Law of Moses, but rather the Law of the Spirit of life in Christ Jesus (Romans 8:2). The point here is not about legalism. The Law represented God's counsel and wisdom to Israel as to how they should run their society and show their faithfulness to Him. For Christians today, we also need to heed God's counsel and his wisdom in order to stay in fellowship with God and show our faithfulness to Him. However, we have the Gospel from Jesus and His apostles. We need to listen to the counsel that they give us. Jesus will not lead us towards wickedness, sin, or mocking.
We should also note that it says that we should delight in God's Word. This represents an emotional response to the grace that God gives when He gives us His Word, His wisdom. If we are to do well this year, we will need to delight in receiving God's Word and then follow it.
Secondly, we should embrace meditating upon God's commands. It is not enough to merely hear God's Word. We are told to meditate upon what He says. This is an inner dialogue that we can have with God in which we contemplate His Word, how it applies to us, and what obstacles we need to overcome. The focus is to fill our minds with the understanding of God's counsel and commands. This involves recognizing and casting aside those understandings and counsels that are adverse to Christ. If we do not take time to meditate about our choices in this life, we will fall far short of walking with the Lord. If we are to do well this year, we will need to set aside time each day to meditate about the path in front of us, and prayerfully ask God to help us see His path.
In verse 3 we see the effect of the path that we walk upon our life. Those who walk with the Lord become fruitful and beneficial to others. This image of a fruit tree may somewhat conflict with the imagery of walking with the Lord. However the difference in imagery helps to further explain what is intended for us to see. The one who is walking with the Lord is simultaneously a tree in this world. The rivers of water point to the need for trees to have water. Without it there can be no growth. God and His Word is our source of water. When we are connected to God as our water source then we will become fruitful.
Now the whole point of a fruit tree is to provide something for others. Apple trees do not eat their own apples. Our growth is not about getting all sorts of stuff to feed ourselves. The one who follows God's path becomes like a tree laden with fruit and all who come upon them can find good sustenance from them. What kind of fruit am I in the life of those around me? If we are to do well this year then we must turn our roots towards the waters of life, and not the stagnant waters of this world. Then we will be fruitful and beneficial to those whom God has put in our life.
Walking with the Lord also makes one to prosper. "Whatever he does shall prosper." With so many teachers talking about prosperity, it would be good to pause and remind ourselves of what prosperity is and what it is not. For many it only means to be financially wealthy and physically healthy. However, in pursuing these things we can often be feeding the lusts of our own flesh. We can promote greed, selfishness, lack of discipline, and idolatry as we try to prosper. We cannot serve God and wealth!
Instead, the New Testament emphasizes spiritual prosperity above material prosperity (I did not say instead of). It is not that God will not take care of our material needs, but that our flesh gets too attached to material prosperity at the expense of spiritual prosperity. Thus we are called to be thankful and content with whatever material things God supplies, be it little or much. We are to be other-focused and become spiritually beneficial to people around us, and, as the Lord directs and supplies, materially beneficial to them as well. Ultimately we worship God and serve Him, rather than dollar signs and looking good in front of other people. If we are to truly be prosperous this year, then we will need to break down the idol in our hearts that wants to be rich and satisfy all the desires of our heart. Then we will truly prosper.
Verse 4 reminds us that if we don't walk with the Lord the effects will be negative. The ungodly will not be like a tree that has plenty of water and bears good fruit. Though the psalmist could have stuck with the tree imagery and said that they produce poisonous fruit, he doesn't. We switch to another metaphor, that of wheat. The wheat metaphor makes it clear. The ungodly will perish.
Wheat has a hard shell that must be broken off of it in order to get to the useful food beneath. The broken remnants of these shells are called chaff. It was common to crush the wheat and then throw it into the air. The wind would blow the light and insubstantial chaff away, but leave the heavier, good wheat behind.
This metaphor can be taken two ways. First, all the trials and difficulties of this world have the effect of separating us into two categories. We are either wheat that will be gathered into God's barn, or we are chaff that the wind of God will blow away.
Second, we can also recognize a further truth that all the trials and difficulties of our life are testing and breaking the chaff off of us. If we will allow Him, God will use those pains and hurts to break off the hard shell around our heart and remove it far from us. We can become that which is good and the bad part will be blown away by the wind of God. Though this image doesn't bring up the sense of God's love for His people and His desire to be loved by them, its lesson is still important. God is always working to remove the bad and protect the good. If we are to do well this year then we must learn to cooperate with this work in our life. Quit worrying about those who reject God. Even if they seem to prosper and seem to be so substantial in this world, the day will come when the wind of God will blow them away and they will perish. Don't seek to be like them, rather seek to tell them about God's love for them.
The psalm ends with the warning that the ungodly will not stand in the Day of Judgment. We will all one day stand and give account to the God of heaven, specifically Jesus Christ. In that day those who have walked with Him will be blessed and enabled to stand, but those who have rejected His ways, mocked and derided them, will recognize their folly too late. Don't be such a person and don't make such mistakes. In fact, be a tree of life that when such a person crosses your path, you have enough power of Christ within you to get their attention. If we are to do well this year, then we need Christ to help us offer something helpful to the lost world around us.
May this year be a year in which you walk with the Lord and are truly blessed.
John 15:1-8. This sermon was preached by Pastor Marty Bonner on February 5, 2017.
Our mission statement, here at Abundant Life Christian Fellowship, is: Connecting people to the Abundant Life found in Jesus. This is a brief and succinct way of saying what our Lord has told us to do. Connections are a big part of what God is trying to do in this world. Yet, these connections must be more than just a natural thing. This all starts with making a spiritual connection to the ultimate, spiritual source of life that is found in Jesus.
Let's look at verses 1-3 first. Jesus describes the metaphor and identifies what each part signifies. Jesus is the true vine. His disciples are the branches that are connected to him. The Father is the gardener who is tending to the branches of the vine in order that it might bear more fruit. Jesus doesn't explain how they became branches connected to him. So let's flesh that out a bit.
How does one get to be a branch connected to Jesus? John 3:16 becomes a good starting point. "For God so loved the world that He gave His Only Begotten Son that whoever believes on Him shall not perish but have everlasting life." Thus the connection begins with belief in Jesus (Faith, Trust). Do you trust that the work of Jesus on the cross covers your sin? And, do you trust that following him as your master will lead to eternal life? If you do then the Spirit of God connects you to Christ by taking up residence within you. John 1:12-13 also says, "But as many as received Him, to them He gave the right to become children of God, to those who believe in His name: who were born, not of blood, nor of the will of flesh, nor of the will of man, but of God." Thus when the reality of who Jesus is comes to us, we must receive Him as He is, God's Son. Still, our spiritual birth is a spiritual thing, not a natural thing. No one becomes connected to Jesus because they were born in a particular family or of a particular race. We must individually believe in Him. Lastly Romans 11 tells us that God grafts us into the olive tree, which is Jesus, so that we can partake in the life of the tree and its roots. So we have a part in receiving the Truth that God gives us about Jesus and believing Him enough to follow Him. God does the spiritual part of connecting us spiritually to Jesus.
Notice that Jesus calls himself the "true" vine. He doesn't say anything more about that in the rest of the passage, and so we might miss its significance. If there is a true vine then it implies that there has been a false vine or many false vines. The presence of a false vine had been promising life, but had actually delivered spiritual death to the religious leaders of Israel. They had been tempted to connect to something other than the One, True God. Of course, on the surface it looked like they were. But that was only a superficial connection. Their true spiritual connection was to the ways of the world, to the devil himself. This is our human predicament. We tend to connect to all manner of things that we hope will bring us life, but they never satisfy. Jesus is the true vine that will actually deliver on the life that it promises. He is not a pretender.
In verse 2 we are told that the Father prunes the branches because He wants them to be fruitful. So what is this fruit that God desires? Just as Jesus is a life giving vine, so God wants us to be life giving branches. The fruit represents that which gives life. Galatians 5 tells us that the fruit of the Spirit of God in our life is Love, Joy, Peace, Patience, Kindness, Goodness, Faithfulness, Gentleness, and Self-Control. But it also says that the fruit of my own flesh and connection with this world is: sexual immorality, impurity and debauchery; idolatry and witchcraft; hatred, discord, jealousy, fits of rage, selfish ambition, dissensions, factions, and envy; drunkenness, orgies, and the like. Then Paul says, "I warn you, as I did before, that those who live like this will not inherit the kingdom of God." So there is a certain amount of cutting that happens in the life of a follower of Jesus who is spiritually connected to Him. They will be pruned so that they can be more fruitful. Pruning always starts with cutting off the dead stuff. It stresses the tree and robs it of strength to grow more fruit. Pruning also cuts off perfectly good twigs. This is done because sunlight and oxygen have trouble hitting all parts of the tree. We can complain with things that God removes from our life, but He does so for our own good; that we might be a fruitful branch.
Verses 4-8 give us a better picture of what it means to draw life from Jesus and it begins with a command. It is not enough to connect to Jesus for a moment or temporarily. We must abide in Him. That word is also translated as "remain," or "dwell." Jesus needs to become the source that we are hoping to draw life from. And, in those times when we are tempted to find another source, we must resist the urge to move. It doesn't work to "try" Jesus for a week, a month, a year, or decade. We must remain in Him and keep drawing into ourselves the life that He is supplying. So the temptation comes from our flesh and the world around us to disconnect from Jesus and to connect to the so-called life of this world. But in the end it only leads to death. This is what Adam and Eve faced. They were living in connection to God. It wasn't just superficial. He was their very life. But one day the devil comes as the serpent and tempts them to connect to something else. You can't have both. To connect with the wisdom of the devil is to automatically disconnect from the wisdom of God. And thus, death entered the world.
In verse 5 Jesus makes it clear that producing any real fruit is impossible without Him. Some people's lives look very fruitful because they are making money and living the high life. But, that is not good fruit that gives life. You can accomplish all manner of things without Jesus, but none of them will satisfy your soul and give you a life that is so powerful that it is eternal. Fruitfulness that is recognized by God is only accomplished by following Jesus and nothing else.
In verses 6 and 7 we are reminded again that the connection must be a living connection. There must be life flowing from Jesus to us. Now this part of the passage can be seen as each branch being an individual person. From time to time God cuts off those who have remained in His Church but are only pretending a connection to Him. They refuse to draw life from Him by trusting the way of Jesus. However, it is also true that God goes through our life from time to time and asks us to surrender particular areas of growth that may not be bad in and of themselves. But, they must be removed if we are to be fruitful. So Jesus points to His Word remaining in us as a further description of Him living in us. When we hear the Word of God it is speaking to us about what should be cut off and what should be encouraged to grow. The Holy Spirit also convicts us in our hearts to surrender in trust to the words of Jesus. In these moments we either draw life from Christ or we harden our heart towards his life. The enemy of our souls seeks to make us question God's Word and quit trusting, believing it. This is what he did with Adam and Eve. "Did God really say…" Always, he seeks to break that living connection that we have with the Spirit of God.
Lastly in verses 7-8 Jesus speaks to the area of prayer. He points out that our prayers are affected by this connection. The disciples were often amazed at the power of Jesus' prayers. For our prayers to be answered we must have a living connection with God. That living connection is maintained by hearing and putting our trust in it. Yes, it is important to obey God's word, but we must do more than that. We must obey out of a trust in God himself and all that He says. Now some people try to take this passage to mean that you can have anything you want if you are connected to Jesus. But, don't forget that a living connection to Jesus will change what your heart desires. At least it will cause the things of God to rise to the top. When you are trusting in Jesus you aren't praying from the desires of your flesh. Instead you are praying from a heart and life that has learned the wisdom of God's pruning. Even in our prayer life, God is trying to teach us how to prune our own prayers. Do you want your prayers to be fruitful? Then learn to pray in accordance with the Spirit of God, rather than the lusts of your flesh. Our lives can bring glory to God when we trust Him and prayerfully ask His help in this life.
I pray that you have made that connection to Jesus. But if you haven't don't let another day go by without letting go of the false vine of this world and the false life that it promises. Take hold of eternal life today by putting your faith in Jesus. Then start drawing life from Him immediately by entering into a trusting relationship with Him.
Mom and Dad, I just want you to know that everything I've written so far in this letter is false. None of it is true. But, Mom and Dad, it IS true that I got a C- in French and flunked my math class…and it IS true that I'm going to need some more money for my tuition payments.
Being a mom is a difficult task that presents a unique set of challenges. Yet, it is easy to lose perspective about it. What is it I am really supposed to do? What is success and what is failure? Today we are going to look at three phases of life for moms: before being a mother, during the child rearing years, and after the kids leave the house.
Is Motherhood To Be Desired?
Over the last century being a mother has come to be a despised thing in some circles. Whether it is Margaret Sanger calling for a 10 year moratorium on child births in the 1940's or modern arguments that refer to motherhood as an enemy to women, a mom and dad raising a kid have much to overcome. So, for a young woman, a very serious question to wrestle with is this: Is motherhood to be desired? Is it some ancient form of slavery and restriction of women? Does it necessarily ruin your professional and marital life?
Now before we deal with this question, I want to recognize that there are many women who, for one reason or another, have not or cannot have children. I do not intend to diminish the difficulties of desiring to give birth to a child and being told you can't. Let me just say to those who are in that situation, trust God and talk with Him about your desires. He may have something different for you that can be just as rewarding, whether becoming a foster parent, simply blessing kids around you, or mothering children spiritually. So don't make the act of birthing a baby of your own, the end all, of life and purpose.
Let's go back to the question of the desirability of being a mother. In Genesis 1:27-28, we see that motherhood is part of God's design for women. A man and woman coming together in a committed relationship to create the next generation is part of God's design of humanity. Whatever motherhood is, women were designed for it and it is not just a good thing, it is a God thing.
We also see in this Genesis passage that God refers to this process with the metaphor of being fruitful. This is a powerful picture because no one would say that a tree without fruit is useless, and yet a tree that has fruit is something quite different altogether. Throughout the Bible fruitfulness is more than physically giving birth to a child. It is at its core a giving of life. Yes, a child is birthed. But it must be cared for and nurtured for it to be able to come to a point where it can live on its own. Thus a woman's fruitfulness is more than giving birth. It is her ability to come alongside of another and give life to them. This can be done regardless of one's ability to conceive. In fact the case can be made that the physical fruitfulness becomes a curse if the higher fruitfulness of physical and spiritual nurturing is neglected. Rotten teens are not an argument against raising children. They are an argument against the lack of a higher order of birthing that must happen. The conception to birth process can be seen as an analogy of the higher order process that brings a child from birth into adult society.
In Psalm 127:3-4 we are told that children are an inheritance from the Lord. In other words it is a portion that he has for many women that they can enjoy and tend to it. It is not the only possible inheritance for women in life (If you are unable to have children recognize that God has an inheritance for you). But neither should it be slighted as undesirable.
Motherhood is something that is good and desirable. Take time to walk with God and He will make it clear if you are to be a mother or not. Don't lose perspective of the fact that you will come to the end of your life and there will be no going back. Yes, we all have regrets, but don't wall yourself off from motherhood without first spending the time in prayer to seek God's will.
Am I A Failure As A Mother?
Once a woman has had a child, or more, it is very common to be plagued with doubts as to your success at it. In fact they are very rarely doubts. Generally you may feel quite sure that you have failed at it. In Psalm 119:105, we are told that the Word of God is a lamp to our feet and a light to our path. Thus, if you feel that you are a failure and don't know what to do, turn to God for wisdom. Let His Word shed light on what you should do.
James picks up on this in James 1:5. However, he not only counsels us to let God's Word be a light to our path, but also counsels us to pray and ask for it. Reading God's Word is the content side, but we also have a spiritual and emotional side. Spend time in prayer asking for wisdom to raise your child. On top of this we can take our anxieties and worries, and put them in God's hands because we know that He cares for us both emotionally and practically.
Now here are some rapid-fire encouragements that all of us know, but need to hear often. Be realistic in how you judge yourself. We can expect far too much of ourselves and our children. In fact, a unrealistic expectation can make our "failures" even worse, by an unhealthy emphasis on perfection. Relax and realize that you are not God. There is only so much that you can do. God does not expect you to be super-mom. But you can be a supernatural mom by relying on God for His help.
Also, learn to prioritize. Priorities help you to decide between what is going to get done and what isn't. Being a parent is one of those jobs that is never done and you're always on the clock. Many things that we see as failures are simply our limitations as a human. You can't do everything and God doesn't expect it from you. Prayerfully set priorities that make the really important things primary and the not so important things tertiary at best.
Another important thing is to find some friends that can understand what it means to be a mother. The power of being able to talk with someone who understands us cannot be underestimated. Don't wall yourself off from others because you are such a "miserable failure." Isolation can make a person feel lonely even when they are surrounded by family. So purposefully counteract it by seeking out friends who are raising kids themselves. Alongside this, you can pray for God to lead you to a good mentor who is further along in life, a seasoned mom who can help you gain perspective. In the now it feels like it is never going to end. But a mom who has raised her kid can help keep you encouraged. Normally this would be your mom and/or grandma. But if this isn't an option for you, don't sit there. Proactively seek out a mentor.
It is called the empty nest syndrome. Some people look forward to the empty nest with far too much glee and, yet, others dread it with far too much gloom and depression. A hyper-desire for what is down the road can adversely affect our actions in the now. No, you don't have to be perfect, but you do need to be engaged in the here and now. Emotional abandonment can be a very heavy thing to place upon the shoulders of a child. On the other hand, those who are depressed over the emptying of their nest can develop an unhealthy selfishness and lack of faith that God has other good things ahead for you. If God gave you kids to enjoy then He will be faithful to give you things to enjoy at the next stage. Yes, all you have known for the last 20-30 years is suddenly gone and you face an unknown future. But you have been there before. The same God who has led you to this point has a plan forward. Take His hand and rejoice!
We see such attitude in Hebrews 11:24-27. Moses is given a task by God. He knew what was being asked on the macro-level. But there was much ahead that required trusting God. Surrender to the next stage and let God lead you forward just as God led Moses. There is a reward ahead. This highly transitional time can go in many different directions and will definitely go through several transitions. Some of them will be your choices, and yet, some of them may not. Many a couple has emptied the nest only to immediately be presented with failing parents who need their care. Or perhaps you have an adult child who has special needs and will never be able to live on their own. Many things can lie ahead: grandkids, travel, new professions, hobbies, and expanded horizons. No one thing is necessary for you to have a full and rewarding life. The only thing you really need is to trust God as He leads you into the next phase of your life.


I believe in my clients, often rather more so than they do in themselves, and we coaches believe you already have all the answers inside, especially when it comes lack of focus, how you procrastinate, why you don't practise extreme self-care and why it's different for you.
But it's all rather different when it comes to money and business, because you don't know all those answers. You haven't necessarily got the wisdom innately just lurking inside you waiting for me to ignite it, although sometimes when ignition happens you might easily say "oh yes, I knew that" and you mean instinctively. But knowing isn't all, you'll be wanting to take inspired action as well.
A business mentor doesn't necessarily know all the answers either. But she may have 35 years' experience of running her own serial businesses and those of her accounting clients and if she doesn't know, she usually knows a woman who does. And often she can get you an appointment to speak to that woman who may also be delighted to help you.


Immediate reconstruction after mastectomy became confirmed treatment that brought breast cancer patient better esthetic benefit. Recently many comparatively locally advanced breast cancer patient also became to receive this operation.The purpose of this present study is to investigate prognosis in patients with/without immediate reconstruction.
A retrospective study on 353 patients (stage II-IV) who underwent mastectomy and had pre/post operative chemotherapy in our institute between 2007 and 2014 was conducted. 39 patients (11% of all) had immediate reconstruction (IR), and 314 patients had mastectomy only (M). Clinicopathological predictive factors, operation procedure, and prognosis (local recurrence or distant metastasis) were collected by chart review.
Patient stage in each group (IR/M) was stage II (23/181 case), III (11/73 case), IV (5/60 case). Median tumor size was 3.6/3.9 cm.(range 2.1-14/2.1-12 cm) As to reconstruction, operation procedure was 6 of implant, 11 of latissimus dorsi muscular flap (LD), and 22 rectus abdominis myocutaneous or deep inferior epigastric perforator flap. Local recurrence occurred 5 cases (9.6%) in IR, 20 cases (6.4%) in M, respectively. Median DFI was 12/42 months. 13 cases (25%) in IR developed distant metastasis, 12 cases (3.8%) in M. Univariate analyses on prognosis by the Kaplan and Meier method shows significant differences between IR and M in regard to both local recurrence and distant metastasis. Among clinical characteristics and operation procedure investigated, presence of high Ki-67, triple negative, and advanced stage was significantly associated with poorer prognosis while other factors including age, tumor size, reconstruction procedure were not significant.
Immediate reconstruction was found to be significantly associated with higher recurrence and distant metastasis rate. Furthermore, high Ki-67, triple negative, and advanced stage are more important notice in the treatment of locally advanced breast cancer.


This page (together with the documents referred to on it) tells you the contractual terms which you accept by purchasing one of the $1 experiences that are on offer for Screw it, let's do it Sunday (the "Terms").
We recommend that, if you intend to purchase an Experience, you print a copy of these Terms for your future reference.
1. The promoter is Virgin Holidays Limited, Registered office: The VHQ, Fleming Way, Crawley, West Sussex, RH10 9DF. ("VIRGIN HOLIDAYS").
4. Please note you will be allocated on a first come, first served basis with a select number of the experiences available.
6. The $1 experiences are only on offer for one day, Screw it, Let's do it Sunday: Sunday 21 January 2018, between 10:00 and 18:00.
7. There is only a limited amount of 200 discounted experiences on offer, with only a set amount available on each experience.
10. A code can only be used on one booking with no more than two adults. Children are excluded from the offer.
11. This code cannot be used in conjunction with any other offers, promotion or discount including Frequent Virgin Club, Virgin Atlantic Flying Club and Tesco Clubcard.
12. The $1 experiences costs will be charged to the purchaser in dollars. The exchange rate in pound sterling (GBP) will be calculated by your bank. Please note that further foreign currency charges may apply – please check with your bank for details.
13. Virgin Holidays does not accept responsibility if you are not able to take up the Experience. In such event, the booking will not be refunded.
16. No more than one experience may be purchased per person.
18. Virgin Holidays may disregard any entry it believes has been made in breach of these Terms.
19. Experiences are subject to availability. Once all have been purchased, no further opportunities will become available.
22. The closing date for purchasing experiences will be 18:00 (UK time) on 21 January 2018 ("Closing Date"). After this time, no further experiences can be purchased.
23. A purchased experience is non-transferable, non-refundable, non-negotiable, cannot be sold and no cash alternative is available.
26. Receipt of purchase will not be acknowledged. Virgin Holidays does not accept any responsibility or liability for any purchase not successfully completed due to a technical fault, technical malfunction, computer hardware or software failure, satellite, network or server failure of any kind.
29. Purchasers may be asked to take part in free publicity surrounding their Experience but participation in such publicity is not compulsory.
30. Virgin Holidays is not responsible for printing or typographical errors in any promotional materials relating to the Experience.
33. By entering, you agree to release Virgin Holidays from any liability whatsoever for any claims, costs, injuries, losses or damages of any kind arising out of or in connection with the promotion or with the applications for a discounted Experience (except death or personal injury caused by Virgin Holiday's negligence, or fraud, or otherwise as prohibited by law).
34. Virgin Holiday's decision is final and no correspondence will be entered into.
35. Events beyond our control: Events may occur that render the Virgin Holidays Screw it, Let's do it Sunday $1 experiences give away itself or the selection of a recipient impractical due to reasons beyond Virgin Holiday's control. We may, at our discretion, make such variations or amendments to the give away as we feel are necessary as a result of such events.
36. Cancellation of the discount offer: Virgin Holidays reserves the right to cancel, terminate, modify or suspend the $1 experiences offer for a day in whole or in part at anytime.
37. The Purchaser shall be subject to the terms and conditions of $1 experiences offer on Screw it, Let's do it Sunday.
Virgin Holidays reserves the right to hold void, cancel, suspend or amend the promotion where it becomes necessary to do so.
These Terms are governed by the laws of England and Wales and entrants submit to the exclusive jurisdiction of the English courts.


Moving Up Arkansas (MUA) is a migrant summer school program offered to high school students of migrant families in Arkansas. Each student must complete an application in order to be eligible. If approved, students are able to attend classes in order to acquire credits. There are several classes offered. Some include English, Civics, History, Algebra, and Geometry. The class sizes are small so the certified teachers can provide individual attention to his/her students. MUA classes are held on the campus of Arkansas Tech University in Russellville, Arkansas and last two weeks - one week for each semester credit.


text:
Q: New line issue when testing mobile app on a real devise (iPhone - Safari) I have a mobile app, which contains a manually created icon - a circle with some text and number inside. It looks and works perfectly when testing it on PC; however, on a mobile device - text gots broken to a new line. I am sure there is enough space for it.
My question is - what can be the issue (something wrong in my CSS?), and how can it be fixed (for example, force it staying on the same line)?
CSS
.title-circle {
  width: 65px;
  height: 65px;
  background-color: #eb5505;
  border-radius: 50%;
  display: flex;
  align-items: center;
  justify-content: center;
  flex-direction: column;
  margin-right: 0.9375rem;
}
.title-circle-txt {
  position: relative;
  top: 0.2em;
  color: #fff;
  text-align: center;
  font-size: 9.5px;
}
.title-circle-txt span {
  font-size: 24px;
  display: block;
  line-height: 1;
}

HTML

Point
1

A: you set .title-circle-txt span class css property display: block;. display: block; property creating the issue. change display: block; to display: inline-block; it will be fix.
.title-circle-txt span {
  font-size: 24px;
  display: inline-block; /* block to inline-block */
  line-height: 1;
}

Here is the example.

redpajama_set_name: RedPajamaStackExchange


On My Way to Emory & Henry College bottle, bib, and rattle set. They're never too young for Emory! This set comes packaged together in a clear, plastic container.
Plush cocoa bear by Mascot Factory. Has an embroidered Emory & Henry scarf. Measures 12" sitting.
Plush marshmallow bear from Mascot Factory. Wears an embroidered Emory & Henry scarf. Measures 12" sitting.
Gold cap embroidered with the wasp. For toddlers. Elastic back.
Navy infant tee by TRT Classics. 100% cotton.
Navy onsie by CI Sport. 60/40 poly/cotton.
Navy cap embroidered with the wasp. For toddlers. Elastic back.
Infant cap, bib, and blanket set by College Kids. 100% cotton. One size.
Pink onsie by CI Sport. 100% cotton.
6" plush unicorn by Mascot Factory.
Light blue bodysuit by College Kids. 100% cotton.
10" Theodore Bear by Mascot Factory.
Navy toddler tee by TRT Classics. 100% cotton.
10.5" Wilson Bear by Mascot Factory.
Crochet youth beanie by LogoFit. 50/50 wool/polyester yarn. Fleece lined.
Light yellow bodysuit by College Kids. 100% cotton.
Daisy yellow infant tee by New Agenda. 100% cotton.
Navy heathered tee by CI Sport. 60/40 cotton/poly.
Youth wasps tee by College Kids. 100% cotton.


text:
Jethro Paine
About Jethro
Jethro grew up in the Balkans, where his dance training began aged six at the Sarajevo National Theatre. He went on to train at the Royal Ballet School and, at the age of 18, moved to the United States to join Boston Ballet II. An injury meant that he had to return home in early 2020, during the COVID-19 pandemic. Jethro recently completed his Bachelor of Arts degree in dance studies (first class honours) and is currently studying part time for a masters in social and cultural anthropology. Having worked with Ballet Cymru in 2021, he is excited to be back in Wales in 2022 and performing with the company!
Other Dancers
Beth Meadway
Caitlin Jones
Chlöe Willis
Isobel Holland
Jacob Hornsey
Jakob Myers
Robbie Moorcroft
Kotone Sugiyama
Sanea Singh
Samuel Banks
Founders & Patrons
Ballet Cymru acknowledges support from
All Photos Copyright Siân Trenberth unless otherwise stated
Charity No. 1000855 Registered in England and Wales as Gwent Ballet Theatre Ltd. 02535169.
Registered office address: Ballet Cymru, Unit 1, Wern Trading Estate, Rogerstone, Newport NP10 9FQ Wales UK


NO CANTEEN WILL BE AVAILABLE, but the Lebrina shop is also next the hall and grounds.
Certificate will be presented instead of prizes.
Lebrina recreation grounds behind the Lebrina Hall, Golconda Road, Lebrina.


text:
@interface NSMutableAttributedString (JSAttributedString)

-(NSMutableAttributedString*)trimString;

@end


text:
Colt helped our family during the most difficult days. Not only was the service beautiful for our Mo...ther. He was there from the beginning to the end. He is caring, genuine and truly a wonderful person. Thank you for all your care, love & respect during this very difficult time. Connelly funeral home of Dundalk is a class act. Thank you again for all your kindness & care. See More
Chadbourn: Dorothy Bass Green, 94 of Chadbourn died Sunday, May 19, 2019 at the Grand Strand Medical Center in Myrtle Beach, S. C.. She was the daughter of the late Richard Dick Bass and Edith Gore Bass and was preceded in death by her husband, Ira Litchfield Green, Sr. . She was baptized at the First Baptist Church in Whiteville. She was a loving homemaker to the complete Green Family. Survivors include two sons, Richard D. Green, Sr. (Zelda W.) of Cerro Gordo, N.C. and David...
Whiteville: Polly Jean Benton Jernigan, 57 of Whiteville died Saturday, April 13,2019 at the New Hanover Regional Medical Center in Wilmington, N.C. She was the daughter of William Cecil Benton and Dolly Ward Benton. She was a former member of New Britton Baptist Church. She worked at Sam's Pit Stop on Jefferson St. for over 26 years as Store Manager. Survivors include her husband, Gary Dean Jernigan, Sr. of the home. Daughter, Amanda Jean Jernigan Price ( Jonathan) of...
Tabor City: Larry Scott Simmons, 46 of Tabor City died Friday, April 12, 2019 at his residence. He was the son of Larry Dale Simmons and Frances Simmons. He was employed by D & S Pump and Supply Company Inc in Whiteville, NC. Survivors include Father, Larry Dale Simmons of Clarendon, NC; Brother, Mark Simmons (Renee) of Nakina, NC; Niece, Jillian Simmons of Nakina, NC. Funeral Service will be Monday April 15, 2019 at 2:00 p.m. at McKenzie Mortuary Chapel with Rev. Chris Hardee...
These are great tools for learning more about our products and services. In addition, we have added several videos that you can use as free marketing tools for your business. These can be added to your website via a link and are perfect for educating your customers on trophy care, mount options and more! To help you reach the full potential of our products, our technical assistants are available Monday-Friday, 8 AM - 5:30 PM Eastern Time at 1-800-279-7985 for any question you may have.
On May 24, 2019 Don B. Brady devoted husband of the late Brenda Brady (nee Burton) for 50 yrs; beloved father of Todd Brady, Steve Brady and his wife Jamie, Kelly Picou and her husband Shawn, and the late Shane Brady; cherished son of Beulah and the late Vernon Deaver; dear brother of Danny Deaver, Vernon Deaver, Jr., Tonya Marceaux and the late Bob Brady; loving grandfather of Nicholas, Colton, Brittany, Carina, Victoria, Noah, Skyla, Jadyn, Caden, Athan, Alec, Ian, Avery and the late...
On May 29, 2019 Mary Delores Ash (nee Hansen) devoted wife of the late John D. Ash, Sr.; beloved mother of Cynthia "Dawn" Gambrill and her husband Charles "Alex", and the late John D. Ash, Jr., and his wife Roxane; loving "Nana" of John III, Kourtney, Zachary and Christina; cherished great "Nana" Jaxon and Charlotte; dear sister of Beverly Parrish, Darlene Wolfe, Margaret Wolfe, Caroline Wolfe, Lolo Clem and Jr Wolfe. Also survived by numerous nieces...
The caring personnel at Connelly Funeral Home-Dundalk provide calming and well-maintained grounds created to meet the needs of each family and to commemorate the lives of these buried at the grounds. The funeral director can guide you through all aspects of the service; including funeral flowers, casket choices, suitable music selection, and local accommodations. Trust is their top concern and they specialize in tradition funerals, basic cremation, grief support, urn selection, and military funeral service services which includes offering veteran burial flags. The professional, devoted staff can help you in making memorial service service preparations, funeral preparation, and talk you through cremation options.
Doris Lee Fowler Bullard of Delco, NC passed away peacefully in her home Saturday, June 1, 2019. She was born January 14, 1934 in Green Sea, SC the daughter of the late Charlie Lee and Jeffie Strickland Fowler. She was the oldest of seven siblings and is preceded in death by her husband, Horace Bullard of Delco, NC and her two sisters Dola Fowler and Margaret Fowler Buffkin. Doris, "Nannie, Aunt Dot, Mrs. Doris, Grandma," proudly served the community for 54 years as the...
Nakina: Jessica Lynn Gore , 33 of Nakina died April 12, 2019. She was the daughter of Debra Fowler Gore and the late William James Gore. She worked as a Textile Operator with National Spinning in Whiteville, N.C. Jessica is survived by her mother; Debra Fowler Gore of Whiteville, four sons; Jonathon Allen McPherson, Christopher William McPherson, and Colton Chase McPherson all of Whiteville, Elijah Riley Porter of Nakina, her fianc'e ; Timothy Alan Porter of Nakina, one brother;...
Please click the red button and browse the entire collection for step-by-step instructions on everything from completing an antler mount to tanning a deer skin. For special instructions that may not be listed, our technical assistants are available Monday – Friday 8 AM to 5:30 PM Eastern Time at 1-800-279-7985 for any questions you may have regarding further instruction.
As a dedicated funeral establishment our responsibility is to the families we serve. We provide the most elaborate funeral service to the simplest graveside ceremony, the most unusual memorial service, to the most basic direct cremation. Since no two people are alike, neither should their funeral ceremony be alike. We are prepared to assist families from every walk of life to create a unique ceremony that reflects a life well-lived.
Monte Hale Formy-Duval, 71, passed away Friday, May 17, 2019 at Duke University Hospital in Durham, NC  He was born in Columbus County, NC on March 30, 1948, the son of the late James Cecil and Emma Gore Formy-Duval. He was preceded in death by his former wife, Mary Ann Brown Formy-Duval and also a brother, J.C. Formy-Duval. Mr. Formy-Duval had retired as a Valve Tech with Nuclear Power Plants.  He was a member of Pleasant Plains Baptist Church.  Surviving is his...
Now that things have finally slowed down and back to somewhat normal, we would like to extend our gr...atitude to McKenzie Funeral Home for making everything perfect. Tim handled the service in a very professional manner, and was there for our every need and concern, Beth was always there to answer every question and if she couldn't she was on it and getting us the answers. They are the most understanding, compassionate people in a time like this. Thank you from Randolph and Christopher for making this experience as good as it could be! See More
On May 29th, 2019 Leroy "Butch" George Jackson, Jr. devoted husband to Teresa Ann Jackson; beloved stepfather to Tanya and Raymond Welsh, Amanda and Martin Satterfield and DeAnna Delcostello; dear brother of John and Ronald Jackson and the late Donald Jackson; cherished grandfather to Katlyn, Desirae, Alyssa, Wyatt, Jaxson, Hunter and Landyn. A funeral service will be held at the Edgemere Church of God, 7414 Ellen Avenue, Sparrows Point MD 21219 on Saturday June 8th, 2019 at...


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The importance of school resource officers
By Denton Postlewait |
Posted: Tue 5:20 PM, Dec 03, 2019 |
Updated: Tue 6:40 PM, Dec 03, 2019
ALTOONA. Wis. (WEAU) The incidents at Waukesha South High School and Oshkosh West High school each involved a school resource officer and show the importance of a district having one in its buildings.
Officer Tim Peterson has been in law enforcement for 10 years. Now, as school resource officer, Peterson said his job title may have changed, but his duties as an officer have not.
"It's basically a small city in itself," Peterson said. "I'm dealing a lot of the same issues as road officers do, it is just within these walls of the school."
Officer Peterson is in his first year as the school resource officer for the Altoona School District.
"I was just learning the job at the start of the year," Peterson said. "I'm starting to get my feet under it now."
But Peterson said he is familiar with Altoona High.
"I graduated from here back in 2003." He said. "It's kind of nostalgic; walking the same halls I used to in high school."
Peterson also walks the halls of the Altoona Elementary and Middle Schools.
"I take probably 12,000 to 15,000 steps a day," he said. "It's all a challenge. It is different than a patrol officer; it's a challenge every day. Whether it could be dealing with a kindergartner who's having a really bad day or a senior who is having drug issues at the school, it varies every day."
Peterson said his main goal is to build positive relationships with students.
"I don't want them to see officers as negative; I want them to them as positive," he said. "Someone they can approach and trust."
For staff, Peterson provides another outlet for students to talk to.
"He's been excellent in times of crisis as well," said Altoona High School principal Jim Reif. "Whether it is a student having suicidal thoughts or students having challenges at home, he is always there to listen and guide them and help them."
Reif said it also provides a sense of security to the district.
"Kids know that he is always around and he is able to approach them. By that same token, if they are having bad thought, he is always around. He is always in full uniform and fully equipped to do his job."
"If they're having a bad day they can come talk to me, or if they know of something bad that is happening in school, they can come talk to me about it," Peterson said.
Officer Peterson also said since he became a school resource officer, it has taught him to be more patient and learn how to handle a wide variety of situations.


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Q: How do I remove the first character of a string and treat the remaining values as an integer in BigQuery I currently am working with a large data set that was pre-populated in BigQuery. I have a column of orderID's which have the following set-up: o377412876, o380940924, etc. This is stored in a string. I need to do the following and am running into problems:
1) Strip off the first character using the BigQuery query language
2) Convert the remaining (or treat the remaining values), as an integer.
I will then run a join against the values. Now, I would be abundantly happier down this operation in either Python, R, or another language. That said, the challenge I have been given based on client needs is to write all the scripts in BigQuery's querying language.

A: SELECT 10 * INTEGER(REGEXP_REPLACE(x, '^.', ''))
FROM
  (SELECT 'o1234' AS x)

12340

A: You can use SUBSTR function and SAFE_CAST (in case there are NULL values in your column). INTEGER does not work on BQ.
SELECT SAFE_CAST(SUBSTR(x, 2) AS INT64)
FROM (SELECT 'o1234' AS x)

Output: 1234


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Бульйо-ін-Монте () — муніципалітет в Італії, у регіоні Ломбардія,  провінція Сондріо.

Бульйо-ін-Монте розташоване на відстані близько 530 км на північний захід від Рима, 90 км на північний схід від Мілана, 15 км на захід від Сондріо.

Населення —   (2014).

Демографія

Сусідні муніципалітети

 Арденно
 Бербенно-ді-Вальтелліна
 К'єза-ін-Вальмаленко
 Колорина
 Форкола
 Торре-ді-Санта-Марія
 Валь-Мазіно

Див. також
 Список муніципалітетів провінції Сондріо

Примітки

Муніципалітети провінції Сондріо


Submitted to our Flickr Pool by Lori Whelan, today's Photo of the Day shows a view of the ongoing restoration of Toronto's Tower Automotive Building on Sterling Road. The historic 1919-built industrial structure will soon live on as Auto BLDG. and MoCA at Lower JCT, part of a mixed-use development by Castlepoint Numa and Greybrook Realty Partners. Once complete, the Museum of Contemporary Art Toronto Canada will serve as a foothold for the development in the increasingly artist-friendly and rapidly de-industrializing area.
Age Of Design, architectsAlliance, Castlepoint Numa, ERA Architects, Greybrook Realty Partners, RJC Engineers, SvN, TACT Architecture, Urban Strategies Inc.


Far from movie poster design trends, there are some that design from a different, an alternative visual perspective, their own. A look at some redesigns of popular movie posters.
With this post I want to show a parallel presentation between the original and alternative movie poster design. Why? Well, because it's interesting to analyse and see if they deliver the message, especially looking at the gap between the targeted audiences (some movies are 30 years old) and the designers style and his understanding of the movie.
A ruthless mercenary renounces violence after learning his soul is bound for hell. When a young girl is kidnapped and her family slain by a sorcerer's murderous cult, he is forced to fight and seek his redemption slaying evil.


Luxury flat 3+1, total area 100 sq.m., 4th floor with elevator. The flat has two bedrooms (one with double bed + single bed, second with a double bed), living room with another double bed, kitchen and 2 bathrooms (one with bathtub and second with shower).
The bathrooms (bathtub, shower stall, valves) Grohe + Nattuzi, heated floors, combinated wood + tiles. Apliances: washing-machine, drier, dishwasher and refridgerator. TV, high speed Internet access etc. Electronic window blinds. The apartment feature free WiFi internet access.
The price is for 1-7 persons per night, including bed linen, towels, internet connection and energy consumption.
Airport/train/bus station transfer is offered for 27 € (4 persons), minibus 39 € (up to 8 persons).
Cleaning fee is paid once per stay 50 €.


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Three Generations of Vigilance - A local family's impact on sport in our region
BY CURTIS J PHILLIPS — Email
Gold and sugar are two of the main exports of Guyana. However, in 1969 a young man in his 20s, by the name of Compton Vigilance, left this South American country, then known as British Guyana, to move to Canada.
Ten years later, he relocated to Fort McMurray, Alberta along with his wife Carrolle and sons Colin and Dwayne.
Ever since then, there have been countless golden moments.
Through his dedication to coaching, officiating and volunteering within our community, this sweet man has unlocked the age of enthusiasm in countless athletes, young and old.
Be it basketball, soccer, volleyball or a multitude of other sports, Compton is a familiar face in local sport.
"The main thing I get out of volunteering is seeing the young kids or old kids, by that I mean senior kids in high school, improving," said Compton, who along with his wife, were members of the All Saints Anglican Church, active in the soup kitchen and visiting patients at the Northern Lights Regional Health Centre.
"When you have a kid coming onto your soccer team that cannot kick the ball with their left foot at the start of the season and then you go to provincials at the end of the season and he scores the winning goal with a left foot kick to the corner… that gives you the joy to say you have accomplished something with that kid."
With three decades of coaching at Fort McMurray Composite High School, Compton, who worked at Syncrude Canada, has a Miner Pride award named in his honour.
He also has local soccer pitch named in his honour at Syncrude Athletic Park.
Compton, 70, has guided countless youth to major Winter and Summer Games events. He is like a father to many.
Typical of his dedication, at the 2015 Western Canada Summer Games hosted in the Regional Municipality of Wood Buffalo, he was at the basketball courts and soccer pitch as a marshal, ticket-taker, usher, scorekeeper and the list goes on.
Compton relocated to Edmonton in 2016 due to the fact that their Abasand Heights residence was lost to the fire in early May.
Our city champion now officiates basketball and soccer in the City of Champions.
His son Dwayne (pictured right), 45, is in his sixth year as head coach of the Keyano Huskies women's basketball team competing in the Alberta Colleges Athletic Conference (ACAC).
Compton had coached the Huskies for several years in the Alberta Conference Athletic League prior to their entrance into the ACAC in 2010-2011. He would be an assistant coach for Dwayne for five years.
"I think I have been lucky to be surrounded by people who love sports like my dad," said Dwayne, who played post-secondary basketball in Alberta and British Columbia. "It is easy for me to stay in love for sports with so many good role models around me. I am so lucky."
"My passion comes from my dad. We grew up playing basketball, playing soccer, playing any type of sport to get out of the house. My dad has also taught us that it is about the process."
Dwayne, who coached professional women's basketball in Australia before returning to Fort McMurray, continued: "It's not always about winning. Sometimes when you lose, that is when you win the most as that is where you learn the most. He taught us to have passion for the game and to respect the game and people."
Of his belief in community involvement, Compton, says: "We are not on this earth by ourselves. We are on this earth for each other and to help out no matter who you are…rich, poor, black and white. We have to depend on each other to make sure we are not alone in this world."
Three generations of the Vigilance family are set to light the cauldron finishing the ATCO Torch Relay at the 2018 Wood Buffalo Alberta Winter Games Opening Ceremonies with Compton, Dwayne and granddaughter Jayla, six.
"It is a great honour," says Dwayne. "We have been involved in sports for such a long time as players, coaches and volunteers. It is especially nice for my dad and all of the effort he has put in for several decades. We are all very excited and very humbled."
Previous Article Partners in Promoting Local Youth & Sport - Fort McMurray Public Schools and 2018 Alberta Winter Games
Next Article The Golden Years
CURTIS J PHILLIPS
Curtis J. Phillips has been a sports journalist in print/electronic mediums since 1976. A strong advocate of volunteerism, he is a founding father of numerous local events and organizations including the Challenge Cup and Wood Buffalo Sports Hall of Fame. Phillips is also recognized internationally as a sports historian.
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Rotary Links: A Family-Friendly Golf Course


Featuring the voice of Zawe Ashton. In the far future, mankind has spread throughout the stars. The Galactic Human Empire is ruled by a massive byzantine theocracy, a dense, ancient mess of rituals, dogma and bureaucracy, so old and complex that nobody really understands it all any more.
Fleeing the authorities after selling a batch of dodgy codpieces is Sarah – a small time crook who has got in over her head and is now branded a heretic. Forced along with her are an unlikely crew of reluctant rebels, caught up in the action against their will.
Their friendship is forged in their mutual struggle for survival after it becomes obvious that the Theocracy is interested only in destroying them all.
Backed in to a corner by the vicious regime, they reluctantly begin to build a resistance movement using only their wits and an inexhaustible supply of eagles.


Based until recently in the Twin Cities, Anda Tanaka now lives and works in Boston. In her prints geometric shapes dominate, while ink, colors and textures draw the viewer closer. Tanaka concerns herself with bringing quiet, some order and a sense of balance in what she perceives to be a chaotic world. While some shapes seem unsettled when focused on, overall compositional spaces do bring the viewer's eye to rest. Her esthetic is deeply rooted in a landscape tradition, which her predilection for abstraction cannot obscure. In January of 2018 Tanaka's work was featured in a solo show "Patience and Effort: Printmaking and the Prairie" in the Watkins Gallery at Winona State University, MN.
Silkscreen on white wove paper.Edition of 9.Signed, titled, dated and numbered in pencil.


I love coffee! I love the way it smells, the way it tastes and what it means to me. No, but really... I have at least 4 different ways to make coffee in my house. Living in Italy transformed my relationship with coffee from a sleep over every once in a while to a full fledged committed relationship. Though some would say I am not a TRUE coffee drinker because I often drink decaf, I beg to differ. Coffee was a part of my every day ritual in Italy. I would go to the same cafe, where they quickly learned my name, and as soon as I would walk in the door they would look up and say "ciao, vorrai un cappuccino decafinato?" (would you like a decaf cappuccino?) and with a giant smile on my face I would reply "si, grazie mile." Many hours were spent laughing with friends, learning Italian and creating memories in that cafe. Even thinking of it now brings tears to my eyes and warmth to my heart.
Flash forward a few years with long work hours and a busy schedule. I noticed that coffee with cream was no longer working for me. I was getting jittering and anxious after drinking it and would crash a few hours later. It wasn't until I discovered adding adaptogens and fat to my lattes that I was able to have a cup every day or at least a few times a week. I no longer get the jitters or feel anxious as I am fueling my body with herbs that are helping it to adapt to stress as well as fat that keeps the caffeine from hitting my blood stream so harshly.
One of my favorite coffee companies is Chameleon Cold Brew. Cold brew is great because it is less acidic and has a deep and smooth flavor. Of all the brands I've tried, this one has the best flavor, is organic and is ran by people who are truly passionate about sustainable and organic coffee. I love to heat it up over the stove in the morning with a bit of homemade nut milk and then add it to my blender with ghee, adaptogens and spices. Its the perfect start to the day. Now that the weather is heating up, I enjoy a cold coffee mid morning or early afternoon. I created this Cinnamon Pecan Frozen coffee. It is slightly sweet and completely delicious. I used Astragalus for lung and immune support, cordyceps for an extra energy boost and endurance and reishi for adrenal and nervous system support. Tocos is great to add to any coffee drink as it is a bio-available form of vitamin E and adds a delicious creaminess. You could certainly leave the adaptogens and tocos out (but, like why?). It's the perfect addition to a hot summer day.
Combine everything in a high speed blender and blend on high for 30 seconds to a minute. Pour into your favorite glass and enjoy in the sunshine.