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Use the button below to register any child, 0-18 years old. Questions? Contact the Church Office.
Please give full name, current grade (or age,if preschool), and complete birth date with year.
Please select any health concerns you may have, or that the church Sunday School teachers may need to be aware of.
We have no health concerns for this child.
By checking the box below, you agree to have your child's/children's image(s) used in classroom projects and in church materials, but without name attribution.
Yes, I agree to have my child's/children's image(s) used in classroom projects and in church materials, but without name attribution.
All potty-trained 3 year olds through kindergarteners are invited to attend Sunday school in our preschool/kindergarten room located downstairs. This class is also known as extended session and runs from 10:30 to the end of the service. Parents may come and get their children for communion and return them to the classroom or keep them in the service. The teachers for this class are Alison Buckley and Margie Grimsley. Children must be potty-trained to attend this class.
All children in First through Sixth grades are invited to attend Sunday school! Our classes are downstairs under our worship space. Class begins at 10:30 and ends when the children are brought up into the church to join their families for the exchange of the Peace and for Communion — usually about 11:15. The curriculum for this age group is "Living the Good News", a lectionary-based program that focuses on common themes for the whole parish, young and old. This class will be taught using a rotation model where an adult parishioner commits to teach for three weeks. A second adult helper is always present in the classroom.
Please note St. Paul's Sunday school is peanut/tree nut free.


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Q: Unity Shader Bug I am working on a Unity shader that can display multiple different tiles on a single plane. Unity passes a floating point array to the shader with a list of tile IDs and a 4x4 tile map and for the mostpart it works perfectly, however there is one slight issue.
I have attached an image of the phenomenon, at the seams of the tiles you can see grey lines. I turned on the tile masking to extenuate the issue so it's easier to see.
Below is the shader code:

Shader "Unlit/TileMap"
{
    Properties
    {
        // Texture configuration
        _DiffuseTex("Diffuse", 2D) = "white" {}
        _MaskTex("Mask", 2D) = "black" {}
        _MapWidth("Map Width", int) = 0
        _MaskMapWidth("Mask Mask Width", int) = 0
        _WorldWidth("World Width", int) = 0

        // Global illumination modifiers
        _GlobalLumosity("Global Lumosity", Range(0, 1)) = 1
        _GlobalHue("Global Hue", Color) = (1, 1, 1, 1)

    }
    SubShader
    {
        Tags { "Queue"="Transparent" "RenderType"="Transparent" }
        LOD 200
        ZWrite On

        Blend SrcAlpha OneMinusSrcAlpha

        Pass
        {
            CGPROGRAM
            #pragma target 4.0
            #pragma vertex vert
            #pragma fragment frag
            #include "UnityCG.cginc"

            struct appdata {
                float4 vertex : POSITION;
                float2 uv : TEXCOORD0;
            };

            struct v2f {
                float2 uv : TEXCOORD0;
                float4 vertex : SV_POSITION;
            };

            sampler2D _DiffuseTex;
            float4 _DiffuseTex_ST;

            sampler2D _MaskTex;
            float4 _MaskText_ST;

            uint _ID;
            uint _MapWidth;
            uint _MaskMapWidth;
            uint _WorldWidth;

            half _GlobalLumosity;
            float4 _GlobalHue;

            float _allIDs[16];

            v2f vert (appdata v) {
                v2f o;

                o.vertex = UnityObjectToClipPos(v.vertex);
                o.uv = TRANSFORM_TEX(v.uv, _DiffuseTex);

                return o;
            }

            fixed4 frag (v2f i) : SV_Target {
                float mapSizeModif = 1.0f / _MapWidth;
                float maskMapSizeModif = 1.0f / _MaskMapWidth;
                float worldSizeModif = 1.0f / _WorldWidth;

                // float lightness = tex2D (_MaskTex, i.uv * _MapWidth);
                float lightness = 1.0f;

                uint index = (int)  (floor(i.uv.x * _WorldWidth) +
                                    (floor(i.uv.y * _WorldWidth) * _WorldWidth));

                i.uv.x = i.uv.x % worldSizeModif;
                i.uv.y = i.uv.y % worldSizeModif;

                uint id = (uint) _allIDs[index];

                i.uv.x += mapSizeModif * (id % _MapWidth);
                i.uv.y += mapSizeModif * floor (((float)id) / _MapWidth);

                fixed4 col = tex2D (_DiffuseTex, i.uv);
                col *= _GlobalLumosity;
                col *= _GlobalHue;

                col.a = lightness;

                return col;
            }

            ENDCG
        }
    }
}

And here is an image of what happens:

I feel like some sort of padding would be needed to fix this issue but I don't know what kind of padding I would need. I feel it has something to do with the lines, and an issue that involves some sort of floating point accuracy error:
// Convert position into localised scaling
i.uv.x = i.uv.x % worldSizeModif;
i.uv.y = i.uv.y % worldSizeModif;

And this is the MonoBehaviour controller that sets the tile information:
void Update()  {
    propBlock.SetFloatArray("_allIDs", new float[16] { 1, 1, 3, 2, 1, 1, 2, 2, 1, 3, 2, 1, 1, 2, 1, 1 });
    renderer.SetPropertyBlock(propBlock);
}

I thought it may be simple texture bleed between the tiles, however, even when forcing it so that no tile bleed is possible (by putting an offset on the UV) it still happens
Any help would be appreciated
Let me know if there is any more info you'd like

A: The problem here is that the lowest mip of your texture is being fetched on some pixels, showing up as the average of your picture (gray-ish). The reason for this is that mip level is computed based on the derivative of the texture coordinates, which works when they are continuous (in screen space), which is not your case since you do a modulo per pixel.
You can get around this by using tex2Dgrad (https://learn.microsoft.com/en-us/windows/desktop/direct3dhlsl/dx-graphics-hlsl-tex2dgrad) and passing the derivatives of the continuous UVs, using ddx() and ddy()

redpajama_set_name: RedPajamaStackExchange


text:
Conren to Build 108 Homes on the Site of Hotusa's Failed Luxury Hotel in Barcelona
The fund manager has purchased a plot on Paseo de Sant Joan where the Hotusa chain had been planning to build a five-star hotel.
The real estate manager Conren Tramway has acquired a plot of land located at the intersection of Paseo de Sant Joan and Avenida Vilanova, in the Eixample district of Barcelona, next to Arco del Triunfo metro station.
For more than a decade, the land has belonged to the Hotusa hotel group, which had planned to build a unique luxury hotel on the site. However, first, the refurbishment and expansion of the nearby metro station, and then the approval of the hotel moratorium launched by the city's mayor Ada Colau when she arrived at the town hall (which prevents the opening of new hotels in the city centre) put paid to those plans. As such, the hotel group has now decided to sell the plot.
Author Carmel DrakePosted on June 9, 2020 Categories Hospitality, Real Estate News, ResidentialTags barcelona, Conren, homes, Hotusa
Realterm Enters Spain with the Purchase of a Logistics Warehouse in Barcelona
Realterm Logistics, a US investment group specialising in logistics properties in the United States, Canada and India, has arrived in Spain with the acquisition of its first warehouse in the town of Palau de Plegamans (Barcelona).
Realterm Logistics, a US investment group specialising in logistics properties in the United States, Canada and India, has arrived in Spain with the acquisition of its first warehouse in the town of Palau de Plegamans (Barcelona). The operation, advised by Savills Aguirre Newman, demonstrates the strength of the Catalan logistics market despite the current health crisis generated by Covid-19.
The property is a cross-dock logistics warehouse with a constructed surface area of 6,578 square metres on a plot measuring 14,160 square metres. It is located in one of the most strategic municipalities for the distribution sector due to its excellent communications including the airport (43 km) and the port of Barcelona (30 km) and connections with the city, which is just 25 minutes away. The warehouse is currently occupied by a transport company.
Author Carmel DrakePosted on May 20, 2020 Categories Industrial & Logistics, Real Estate News, Real Estate TransactionsTags barcelona, debut, Realterm Logistics, warehouse
The Previous Recession Lasted 6 Years and House Prices Fell by 30%: What will Happen in this Crisis?
During the crisis that started in 2008, the País Vasco was home to the most expensive house prices, but Madrid saw a better recovery; meanwhile, Guadalajara and Toledo registered the greatest price decreases.
In 2008, the housing bubble that had been growing for almost a decade in Spain, driven by the heat of the country's economic boom, burst. Then, a period of falling prices and declining sales began in the residential market; at the national level, the market had not yet recovered by the time the coronavirus crisis hit earlier this year.
Last time, the fall in prices lasted 6 years, from the first quarter of 2008, when they peaked, to the first quarter of 2014, when they bottomed out. "Between the period just before the real estate bubble burst in 2008 and the moment just before the recovery, average sales prices fell from €2,017 per square metre to €1,414 per square metre, whereby losing 30% of their value", explains Antonio Ramudo, Data Scientist at Brainsre.
At the end of 2019, according to the Ministry of Development, only 53% of the value lost during the crisis had been recovered, with the average price reaching €1,734 per square metre.
In terms of sales, the volume of homes bought and sold per year went from 952,805 in 2016 to just 299,953 in 2013, representing a collapse of 68.5%. By 2019, when 567,753 sales were registered, only 41% of the transaction volume executed at the height of the boom had been recovered.
Although the peak in terms of the volume of house sales in Spain occurred in 2006, when almost a million homes were sold, the maximum average transaction price (€2,017 per square metres) was not reached until the first quarter of 2008. "This shows that fewer transactions were being registered before prices started to drop," says the Data Scientist at Brainsre.
Likewise, the data reveals that, after the 2008 economic crisis, the minimum number of house sales was recorded in 2013, when 299,953 units were sold; meanwhile, the value of those transactions continued to decline until 2014, when in the first quarter the minimum average transaction price (€1,414 per square metre) was reached, a value that had not been recorded since 2004.
In other words, before prices began to increase, the number of transactions began to rise. "An uptick in demand produced an initial increase in transactions and a subsequent rise in prices and, vice versa, the decrease in demand led to fewer transactions being registered and, subsequently, to a decrease in prices," explains Ramudo.
Madrid and País Vasco, the most expensive regions
The regions with the most expensive residential product are also those that suffered the largest decreases in absolute values. In this way, the range between the maximum prices in 2008 and 2009 and the minimum prices reached after the crisis is greater. Such is the case of Madrid, País Vasco and Cataluña.
When the previous crisis began in 2008, the País Vasco was home to the most expensive house prices, but Madrid saw a better recovery, and thus, according to the latest available sales prices, the Community of Madrid leads the ranking. On the other hand, the Canary Islands and the Balearic Islands – regions with the next highest prices after Madrid and País Vasco – have smaller ranges between their maximum and minimum prices, and in both cases, current prices already exceed the peaks seen just before the 2008 crisis.
Where did prices fall by the most last time?
The Autonomous Regions that recorded the greatest drop in prices were La Rioja, Castilla-La Mancha, Aragón and Cataluña, where house prices decreased by more than 40%. Meanwhile, Guadalajara and Toledo were the provinces where prices suffered the largest decreases last time, with collapses of 54% and 53%, respectively. "The large urbanisations of Guadalajara, around the Henares corridor, and Seseña (Toledo) were victims of these sharp price reductions caused by the sudden lack of demand," says the Data Scientist.
The autonomous cities of Ceuta and Melilla and the Balearic Islands recorded more moderate price drops, with a loss in value of 20% or less.
Andalucía was the mainland region that registered the lowest price drop, with a decrease of only 25% compared to the peaks of 2009.
In terms of the recovery, the islands have performed the best thanks to tourism, second homes and international clients. In both the Balearic Islands and the Canary Islands, current prices are at all-time highs.
On the other hand, Madrid is the mainland region where prices have recovered by the most, with almost 66% of their value now restored compared to the maximum pre-crisis prices. Andalucía is the second region in terms of the recovery of prices, with almost 49% of their value now restored. In this sense, Málaga is the mainland province that has performed the best since the fall, as it has now recovered 85% of the value lost during the previous crisis.
The duration of the fall
Unlike the coronavirus crisis, the crisis that began in 2008 reached different Spanish regions at different times. Then, Aragón was the first region to see a decrease in house prices, specifically, during the third quarter of 2007; and Extremadura was the last to suffer, specifically, during the second quarter of 2011, almost four years later.
In terms of the regions with the most activity, Madrid was the market that began to suffer first, since house prices started to fall there in the first quarter of 2008; it was quickly followed by Cataluña and País Vasco in the second quarter of that same year.
After Ceuta and Melilla, the Canary Islands was the region where the recovery from the crisis began first; there, values bottomed out and began to rise in the third quarter of 2013 – four and a half years after prices first started to fall. In this context, Cataluña and the Community of Valencia were the regions that started to recover next; they began to record price increases in the second quarter of 2014.
Madrid, meanwhile, did not begin its recovery until the third quarter of 2015, almost eight years after the first decreases, from an average of €3,045 per square metre -registered at the end of 2007- to €2,029 per square meter in 2015. Extremadura, the region that was hit the latest, was also the one whose recovery started last. It was not until the second quarter of 2017, when prices there stopped falling and began to grow.
In terms of the duration of the crisis, from the beginning until the end of the price decreases, there was also considerable asymmetry between the different regions: from 4 and a half years in the Canary Islands to eight years in Aragon.
The highest prices, which exceeded €3,000 per square metre, were reached in Madrid and País Vasco in 2008. Those two regions saw the lengthiest decreases, since the price falls -of 33% and 31%, respectively- took seven and a half years in total. Meanwhile, in Cataluña, the decrease in prices was greater, 43% of the peak values reached in 2008, but it was faster, with prices bottoming out there after six years. By province, there was even more variation, since in Álava and Zaragoza the price decreases lasted 10 years, whereas in Santa Cruz de Tenerife, Cáceres and Jaén, they barely lasted four years.
No-one knows how long this crisis will last and many indicators are showing that the regions where coronavirus will have the greatest economic impact are those that are the most dependent on tourism, especially in the short term. "Although that may be true, if the experience of the crisis that began in 2008 has taught us anything, it's that the regions that recover first and best are the important tourist centres, such as the Balearic Islands, the Canary Islands, Málaga and Alicante," explains Ramudo.
Prices in the major cities
In the seven most populated municipalities in Spain, the behaviour of the housing market after the bubble burst was relatively similar. Madrid reached its maximum average transaction price earlier than the rest of Spain, in the third quarter of 2007; whereas the Spanish average for that milestone was the first quarter of 2008. Naturally, in other places it was reached later: Valencia, Murcia and Sevilla recorded their peaks in late 2008 and in Malaga the peak was not reached until 2009.
On the other hand, the minimum values were reached between 2013 and 2014 in most regions and since then prices have been rising consistently in the main municipalities.
Strong increase in the sale of new build homes
The years 2007 and 2008 were when the most new-build homes were sold in Spain, with 411,726 such homes transacted. That was also when the percentage of new build sales over total registered transactions reached its peak. Between 2008 and 2009, more than 50% of all sales involved new build homes, a percentage that has gradually decreased until the Covid-19 crisis, although it has remained relatively stable at around 10% since 2016.
In 2016, the new home market bottomed out with just 46,927 transactions registered, representing 11.5% of the more than 409,760 homes that were sold in total (new and second hand). Since then, the number of new homes sold has been increasing slightly, to reach 56,195 operations in 2019.
Had Madrid and Barcelona reached their peaks again?
If we focus on the most important markets, Madrid and Barcelona, we see that in the city of Barcelona, prices reached their peak in mid-2019, at €4,162 per square metre; there, average house prices fell in the last quarter of 2019 to reach €4,131 per square metre. In addition, the volume of transactions has decreased progressively over the last two years – just like in 2008, when prices reached their peak, the number of transactions began to decrease two years earlier.
Furthermore, sales values in Madrid also seem to have peaked, regardless of the health crisis. There, house prices reached €3,362 per square metre during the last quarter of 2019, which was lower than those seen in the previous quarter. Also, the number of transactions registered in 2019 reflected a decrease of 8% compared with 2018.
As we wait for the Ministry of Development to publish data for the first quarter of 2020, and based on the data that does exist, "we observe a slight contraction in transaction values in the main urban centres, which could indicate (leaving aside the consequences of the crisis) a hypothetical fall in prices or at least the stabilisation of them", says Ramudo.
Author Carmel DrakePosted on May 7, 2020 May 7, 2020 Categories Real Estate News, ResidentialTags barcelona, crisis, house prices, house sales, Madrid, recession
Segro Closes 4 Operations and Plans to Invest €1 Billion in Spain
The British real estate company is planning to invest €1 billion in the Spanish market over the next few years. It has just closed 4 turnkey logistics operations and pre-rentals in Madrid and Barcelona, spanning 92,000 m2 in total.
The British real estate company Segro, which specialises in the management of logistics assets, is planning to invest €1 billion in the Spanish market over the next few years. It has just closed 4 turnkey logistics operations and pre-rentals in Madrid and Barcelona, spanning 92,000 m2 in total.
The company, which currently has a portfolio worth more than €400 million that spans 440,000 square metres in Spain, wants to increase its investment to €1 billion "in the medium to long-term", according to the group. Furthermore, its objectives include expanding its portfolio by 200,000 square metres in three years, mainly in the Madrid and Barcelona markets.
Author Carmel DrakePosted on May 5, 2020 Categories Industrial & Logistics, Real Estate NewsTags barcelona, logistics platform, Madrid, Segro
Blackstone Buys La Llave de Oro's Project in 22@ for €100M
17 January 2020 – Idealista
Blackstone has agreed to purchase an office building that La Llave de Oro is currently constructing in Barcelona's 22@ district, in a deal that is expected to be closed for €100 million. The property is located on Calle Sancho de Ávila and will have a gross leasable area of 17,400 m2, on a plot spanning 3,300 m2.
The purchase of office buildings off-plan is becoming a bit of a habit in the Catalan capital's 22@ technological district after the German bank Commerzbank paid €132 million in December for two offices that Conren Tramway is constructing there.
Author Carmel DrakePosted on January 21, 2020 Categories Offices, Real Estate News, Real Estate TransactionsTags 22@ district, barcelona, Blackstone, Commerzbank, Conren Tramway, La Llave de Oro, office building
Bonavista Developments to Invest €40M in the Construction of a 11,500 m2 Office Building in Barcelona's 22@ District
13 January 2020 – El Periódico
Bonavista Developments, through Mitsubishi Estate London and Europa Capital, has completed the purchase of a plot of land in the heart of the 22@ district of Barcelona, on Calle Cristóbal de Moura, for an undisclosed sum.
The two companies are planning to invest €40 million in the construction of a new office building on the site. The new offices are expected to span a surface area of 11,500 m2 and construction is scheduled to begin later this year.
Original story: El Periódico (by Max Jiménez Botías)
Author Carmel DrakePosted on January 14, 2020 Categories Land, Offices, Real Estate News, Real Estate TransactionsTags 22@ district, barcelona, Bonavista Developments, Europa Capital, Mitsubishi Estate London, office building, plot, surface area
Partners Group Negotiates the Purchase of 5 More Office Buildings from Meridia Capital
10 January 2020 – El Confidencial
The Swiss manager Partners Group is in talks with Meridia Capital, led by the Catalan businessman Javier Faus, with a view to purchasing half of the office portfolio that Meridia put up for sale at the end of last year.
The two players enjoy a close relationship following a deal closed last April, which saw Partners acquire a portfolio of 18 offices from Meridia for €215 million, and the Socimi continuing to manage the portfolio.
A similar arrangement could be sought this time around. The portfolio on the table in 2020 comprises a dozen offices in Madrid and Barcelona worth around €200 million, although Partners is only interested in half of the properties.
Both parties declined to comment on the reports of a potential sale, however, sources in the know confirmed that a due diligence process has begun on five of the assets.
Original story: El Confidencial (by Ruth Ugalde)
Author Carmel DrakePosted on January 13, 2020 Categories Offices, Real Estate NewsTags barcelona, deal, due diligence, Javier Faus, Madrid, Meridia, Meridia Capital, negotiation, Partners Group, Socimi
Addmeet: Investment in RE in Madrid Exceeded that in Barcelona by 2.5x in 2019
According to the real estate portal, Addmeet, real estate investment in Spain amounted to €35.0 billion in 2019, of which 70% was concentrated in Madrid and Barcelona (€18.0 billion and €6.8 billion, respectively). The data compiled reflects all real estate operations amounting to more than €3 million in all sectors of the professional real estate market.
In the Community of Madrid, investment broke all records (€18 billion), exceeding the figures recorded in 2018 (€15 billion) and in 2008 (€10 billion). There, the office sector was the main driver, accounting for 61% of the total figure (€11 billion). The star transaction was the sale of Santander's Ciudad Financiera, which the financial entity repurchased from Marme Inversiones for €3.2 billion 11 years after selling it to that same firm.
Other office-related deals included the sale of the La Finca business park to the Socimi owned by the Cereceda family for €423 million; and the purchase by Allianz Real Estate of Castellana 200 (comprising 20,000 m2 in office space and 6,500 m2 in retail area) for €250 million.
The next main drivers were the residential sector, which accounted for 11% of investment (€2 billion), boosted by the build to rent segment, and the retail sector, which accounted for 11.5% of the total investment.
Meanwhile, record figures were also recorded in the province of Barcelona (€6.8 billion) despite the "procés". In fact, the investment volume almost doubled that recorded in 2008 and far exceeded the total recorded two years ago (€5.6 billion).
Like in Madrid, the office sector in Barcelona accounted for most of the real estate investment (46% or €3.1 billion). The retail sector represented 11.5% (€0.8 billion), whilst the hotel segment attracted almost €1 billion (14%) and the residential segment just €0.5 billion.
Major deals in the Catalan capital in 2019 included the sale by Telefónica of Diagonal 00 to the Philippine magnate Andrew L. Tan for €150 million, amongst others.
Author Carmel DrakePosted on January 9, 2020 January 9, 2020 Categories Offices, Real Estate News, Retail & Shopping CentersTags Addmeet, barcelona, Ciudad Financiera, Diagonal 00, hotel sector, investment, investment volume, Madrid, Marme Inversiones, office sector, residential sector, retail sector, santander
HausInvest Returns to Spanish Real Estate Market
6 January 2020 – Real Assets IPE
Commerz Real's €15.5bn HausInvest fund has returned to the Spanish real estate market after more than 14 years.
The German property fund is purchasing two office development projects in Barcelona off-plan for €130m from developer Conren Tramway.
It is the first time the fund has invested in Spain since it acquired the Espai Gironés shopping centre near Girona in 2005.
The two office buildings, which will be built on Carrer de Badajoz in Barcelona, will provide 13,900sqm and 9,300sqm of space, respectively.
Original story: Real Assets IPE
Edited by /Summary: Carmel Drake
Author Carmel DrakePosted on January 8, 2020 Categories Offices, Real Estate NewsTags barcelona, Carrer de Badajoz, Commerz Real, Conren Tramway, Espai Gironés shopping centre, HausInvest, off-plan, offices, surface area
Sales of Offices Buildings in Barcelona Rise by 45%
6 January 2020 – Barcelona is experiencing record sales of office buildings, reaching highs not seen since before the beginning of the financial crisis. The sales are largely driven by high levels of liquidity and low bond yields. Ten buildings worth more than one hundred million euros sold during 2019, pushing total investments for the year to €2.816 billion. That figure is 44% above the amount sold in 2018, according to a report by CBRE.
The profile of investors has recently changed as well, as larger institutional investors looking for stable, long-term returns have slowly replaced more opportunistic buyers. Furthermore, the political turmoil in Catalonia also seems to have failed to scare off most investors.
Barcelona está experimentando ventas récord de edificios de oficinas, alcanzando máximos no vistos desde antes del comienzo de la crisis financiera. Las ventas están impulsadas en gran medida por los altos niveles de liquidez y los bajos rendimientos de los bonos. Se vendieron diez edificios por valor de más de cien millones de euros durante 2019, lo que empujó las inversiones totales para el año a 2.816 millones de euros. Esa cifra es un 44% superior a la cantidad vendida en 2018, según un informe de CBRE.
El perfil de los inversores también ha cambiado recientemente, ya que los inversores institucionales más grandes que buscan retornos estables a largo plazo han reemplazado lentamente a los compradores más oportunistas. Además, la agitación política en Cataluña también parece no haber asustado a la mayoría de los inversores.
Original Story: Expansión – Marisa Anglés
Photo: Elena Ramón/EXPANSION
Translation/Summary: Richard D. Turner
Author Richard TurnerPosted on January 6, 2020 Categories Offices, Real Estate NewsTags barcelona, CBRE, record sales, research reports, sales of office buildings, statistical data

redpajama_set_name: RedPajamaCommonCrawl


text:
package addprefix

import (
	"context"
	"net/http"
	"testing"

	"github.com/containous/traefik/config"
	"github.com/containous/traefik/testhelpers"
	"github.com/sirupsen/logrus"
	"github.com/stretchr/testify/assert"
	"github.com/stretchr/testify/require"
)

func TestNewAddPrefix(t *testing.T) {
	testCases := []struct {
		desc         string
		prefix       config.AddPrefix
		expectsError bool
	}{
		{
			desc:   "Works with a non empty prefix",
			prefix: config.AddPrefix{Prefix: "/a"},
		},
		{
			desc:         "Fails if prefix is empty",
			prefix:       config.AddPrefix{Prefix: ""},
			expectsError: true,
		},
	}

	for _, test := range testCases {
		test := test
		t.Run(test.desc, func(t *testing.T) {
			t.Parallel()

			next := http.HandlerFunc(func(w http.ResponseWriter, r *http.Request) {})

			_, err := New(context.Background(), next, test.prefix, "foo-add-prefix")
			if test.expectsError {
				assert.Error(t, err)
			} else {
				assert.NoError(t, err)
			}
		})
	}
}

func TestAddPrefix(t *testing.T) {
	logrus.SetLevel(logrus.DebugLevel)
	testCases := []struct {
		desc            string
		prefix          config.AddPrefix
		path            string
		expectedPath    string
		expectedRawPath string
	}{
		{
			desc:         "Works with a regular path",
			prefix:       config.AddPrefix{Prefix: "/a"},
			path:         "/b",
			expectedPath: "/a/b",
		},
		{
			desc:            "Works with a raw path",
			prefix:          config.AddPrefix{Prefix: "/a"},
			path:            "/b%2Fc",
			expectedPath:    "/a/b/c",
			expectedRawPath: "/a/b%2Fc",
		},
	}

	for _, test := range testCases {
		test := test
		t.Run(test.desc, func(t *testing.T) {
			t.Parallel()

			var actualPath, actualRawPath, requestURI string

			next := http.HandlerFunc(func(w http.ResponseWriter, r *http.Request) {
				actualPath = r.URL.Path
				actualRawPath = r.URL.RawPath
				requestURI = r.RequestURI
			})

			req := testhelpers.MustNewRequest(http.MethodGet, "http://localhost"+test.path, nil)

			handler, err := New(context.Background(), next, test.prefix, "foo-add-prefix")
			require.NoError(t, err)

			handler.ServeHTTP(nil, req)

			assert.Equal(t, test.expectedPath, actualPath)
			assert.Equal(t, test.expectedRawPath, actualRawPath)

			expectedURI := test.expectedPath
			if test.expectedRawPath != "" {
				// go HTTP uses the raw path when existent in the RequestURI
				expectedURI = test.expectedRawPath
			}
			assert.Equal(t, expectedURI, requestURI)
		})
	}
}

redpajama_set_name: RedPajamaGithub


text:
De 712e Infanteriedivisie (Duits: 712. Infanterie-Division) was een Duitse infanteriedivisie tijdens de Tweede Wereldoorlog. De divisie fungeerde ruim drie jaar als bezettingsmacht en kustverdediging in het westen. Toen de geallieerden in september 1944 dichterbij kwamen, werd de divisie over de Schelde gebracht en in Noord-Brabant ingezet en later boven de Maas en Waal. In januari 1945 werd de divisie dan overgebracht naar het ineenstortende Duitse front in Polen en later ingezet langs de Oder. De divisie werd grotendeels vernietigd in april 1945 in de Kessel van Halbe.

Geschiedenis

Oprichting
De 712e Infanteriedivisie werd opgericht op 5 mei 1941 rond Trier in Wehrkreis XII als onderdeel van de 15. Welle. Opgericht werd Infanterie-Regiment 732 uit Divisie.Nr. 172, Infanterie-Regiment 745 uit Divisie.Nr. 182 en Artillerie-Abteilung 652 uit Divisie.Nrs. 172 & 182.

Bezettingsmacht
De divisie werd in juli 1941 verplaatst naar bezet Frankrijk, eerst naar Bretagne en in september 1941 naar de demarcatielijn met Vichy-Frankrijk. Medio juni 1942 werd de divisie dan verplaatst naar de kust, waar ze het gebied rond Zeebrugge bezette, inclusief de zuidelijke oever van de Schelde. In dit gebied bleef de divisie tot begin september 1944.

Nederland
Begin september 1944 naderden de geallieerden, die oprukten vanuit Normandië, het gebied waar de divisie lag. Tezamen met de rest van het 15e Leger werd de divisie samengedrukt aan de Belgische kust/Zeeuws-Vlaanderen. Vanaf 20 september 1944 werd de divisie overgezet naar Walcheren en kwam rond 23 september aan bij Tilburg. En ging daarna door naar het front ten oosten van 's-Hertogenbosch. Hier kreeg de divisie op 22 oktober 1944 de Britse aanval te verduren van Operatie Alan (deel van Operatie Fazant). Ruim een week later was de divisie over de Maas gedrongen. Hier nam de divisie stelling in op de noordoever. Een maand later werd de sector ingenomen rondom Tiel langs de Waal.

Oostfront
Op 15 januari 1945 kreeg de divisie bevel op transport te gaan richting het oostfront. Al op 17 januari 1945 stonden de eerste delen van de divisie in actie in Polen, bij Żarki en enkele dagen later bij Georgenberg en verder richting Schwarzwasser. Vervolgens werd de divisie ingezet aan de Oder bij Frankfurt (a/d Oder). In de gevechten hier tussen 6 februari en 13 maart 1945 leed de divisie samen met de Pantsergrenadierdivisie "Kurmark"  een verlies van 2000 man. Daarmee was de divisie grotendeels vernietigd en daarop werden Grenadier-Regiment 732, Füsilier-Bataillon 712 en Artillerie-Regiment 1712 in de 45e en 68e Infanteriedivisies ingevoegd, maar de divisiestaf bleef separaat bij Heeresgruppe Weichsel.

Heroprichting
Op 26 maart 1945 werd de divisie alweer heropgericht bij Küstrin, uit de nog aanwezige divisiestaf en enkele regimenten die tijdelijk onder Pantsergrenadierdivisie "Kurmark" bij Küstrin hadden gevochten plus een regiment van Schatten-Division Hannover.

Bij het begin van het Sovjet offensief tegen Berlijn stond de divisie aan de Oder. Deels werd de divisie betrokken bij de Slag om de Seelower Höhen, maar grotendeels gingen de Sovjets langs de noordelijke flank. Wel werd de divisie als deel van het 9e Leger langzaam naar achteren gedrongen richting Fürstenwalde en daarna verder naar het Spreewald. Hier raakte het 9e Leger ingesloten. Toen ontspon zich de Slag om Halbe. In deze Kessel (zak) gezeten, probeerde het 9e Leger uit te breken naar het westen. Slechts een klein deel redde het om aansluiting te vinden bij het tegemoetkomende 12e Leger tot 3 mei 1945. Hierbij bevonden zich ook de schamele resten van de divisie. Het grootste deel van de divisie bleef achter, dood of gevangengenomen door het Rode Leger.

Het einde
De resten van de 712e Infanteriedivisie trokken tussen 3 en 7 mei 1945 over de brug over de Elbe bij Tangermünde en gaven zich daar over aan US-troepen.

Bovenliggende bevelslagen

Commandanten

Generalleutnant Neumann was van 12 tot 29 januari 1944 tijdelijk plaatsvervangend commandant van het 89e Legerkorps en ook nog eens van 30e Legerkorps van 23 november tot 16 december 1944. Verder is hij genoemd als commandant van "Korps Neumann" van 10 augustus tot 23 augustus 1944, waarbij Oberst Fiebig zijn vervanger was.
Generalmajor von Siegroth raakte in de Kessel van Halbe vermist (2 mei 1945).

Samenstelling
1941
 Infanterie-Regiment 732
 Infanterie-Regiment 745
 Artillerie-Abteilung 652
 Divisie-eenheden 712
1943
 Artillerie-Regiment 652 gevormd uit Artillerie-Abteilung 652, eind december 1943 omgedoopt in Artillerie-Regiment 712 en in januari 1944 omgedoopt in Artillerie-Regiment 1712
januari 1944
 Füsilier-Bataillon 712 uit I./Grenadier-Regiment 745
 Ost-Bataillon 628 als vervanging voor I./Grenadier-Regiment 745 ingevoegd
24 december 1944
 een derde regiment voor de divisie, Grenadier-Regiment 764, werd opgericht
maart 1945
 Grenadier-Regiment 732 uit Grenadier(Führungsnachwuchs)-Regiment 1239
 Grenadier-Regiment 745 uit Grenadier(Führungsnachwuchs)-Regiment 1241
 Grenadier-Regiment 764 uit Regiment B (Marburg) van de Schatten-Division Hannover
 Artillerie-Regiment 1712 met alleen de IV. Abteilung

Heer (Wehrmacht)
Duitse militaire eenheid in de Tweede Wereldoorlog

redpajama_set_name: RedPajamaWikipedia


Wichita, Kansas: The Hubbard Dianetic Foundation, 1951. First Edition. Hard Cover. Very Good binding/Fair dust jacket. The first trade edition, with "First Edition" stated on the copyright page.. Typed slip on the front endpaper: "This book should contain two charts eight inches by twenty-four inches in length. If these charts are not in back of the book, please see your bookseller." The two original charts are present, as well as what appears to be two old photostats of the chart. Previous owner name stamped in green ink on the yellow pastedown, as appears to be usual. There is some old tape residue. The dustjacket is present, with tape repairs and loss. Most uncommon. Very Good binding / Fair dust jacket.


The so-called "brain-eating" amoeba, a water-based threat that poses a risk to water utilities, has taken another life.
Fabrizio Stabile, a 29-year-old man from Ventnor, NJ, appears to have contracted the amoeba on a trip to Central Texas. He died on September 21 in the Atlantic City Medical Center in New Jersey.
"Stabile tested positive for Naegleria fowleri -- an amoeba that typically occurs in warm fresh water -- the day before his death," NJ.com reported, citing a GoFundMe page creating a foundation in his memory.
His diagnosis was primary amoebic meningoencephalitis (PAM), a rare condition most recently diagnosed in 2016, according to WIRED. The Centers for Disease Control (CDC) have only reported 143 cases since 1962. PAM's initial symptoms are flu-like.
"This is actually the first time it's been detected in a New Jersey resident," says state epidemiologist Tina Tran, per WIRED. "It's more common in the southern states, where the water tends to be warmer."
Stabile did not immediately realize that his health had been severely compromised.
"On September 16, he was mowing the lawn when he had to stop due to a severe headache. He took medication and slept through the night, but was still dealing with pain the next day, and went back to sleep with more medication. That afternoon, his mother tried to wake him up but Stabile was unable to get out of bed or speak coherently, and he was rushed to the hospital," PEOPLE reported.
It is believed that Stabile contracted the amoeba on a trip to a waterpark in Waco, TX. Officials are testing the water to find out.
The amoeba poses a risk to municipal water systems.
"As rare as PAM is, the amoeba that causes it is common in freshwater. Epidemiologists have found it in lakes and rivers as far north as Minnesota, which saw its first case of PAM in 2010, and in pools, water parks, and municipal water systems across the American south. Researchers at the CDC have gone so far as to call it ubiquitous. Those same researchers predict its range will only expand, as global temperatures increase," WIRED reported.
In 2014, Louisiana set rules for water utilities with regard to the amoeba.
The rule "required that water systems in the state maintain a higher residual disinfectant level and increase their number of sampling sites by 25 percent. Most drinking water systems in Louisiana were required to meet this new higher standard by February 1, 2014," the department said.


We have had this joint venture as FSF since 2004. Although Laura has had agriculture, dairy and dairy goats in her life since the day she was born. Laura grew up on a dairy farm in Upstate New York, involved in every area of the business from bookwork to milking, breeding and field work. As a teenager, Laura wanted to show cattle, and her dad was unsure about that. Not one to back down, she partnered with Heifer Project and was able to start her own dairy goat herd. Chris had limited agriculture experience before meeting Laura, although his extended family has deep roots in West Central MN. Being a quick study and a problem solver, Chris has become equally knowledgeable.
We raise, sell, and show Saanen and Nubian dairy goats. We are very active showing our goats around MN and some in WI. We have shown at a National level a few times. In addition, we participate in DHIA milk testing for our goats, taking advantage of the proven level of production of our herd over generations. We also participate in the linear appraisal program, which is similar to classification in dairy cattle. This helps us evaluate each animal and impact of breeding decisions over time.
Our end customer is usually someone looking to add a highly productive member to their herd. Some are first-time buyers, many are return buyers after valuing the production and longevity of our animals in their herd. Some purchase bucks to bring genetics into their herd over many years, others are looking for a family milker or 4H project for youth. In addition to selling to other people, we also spend alot of time educating others about dairy goats and agriculture. We have participated in many open house events in communities around us. We also value time spent with family and friends at the farm, always having a teachable moment.
We have had 3 consecutive Junior Champion Saanen does at the MN State Fair from 2013 through 2015, and followed that in 2016, that first Junior Champion became our first Senior Champion at the MN State Fair. We exported our first animal to Puerto Rico this year! An amazing experience, and we are so honored that this buyer put so much trust in our genetics.
I love the dairy industry, and dairy goats specifically. There is no other animal with so much personality, intelligence, or humor. I have had dairy goats in my blood since a 4-H project that turned into a business, then came back into my life as an adult. They are my therapy!
We are not licensed to sell milk commercially or sell product (cheese, milk, etc.) to the public.Our main focus in on animal husbandry, genetics, and a high level of management so that the animals can succeed and reach their highest potential.
MN and the Midwest are the center of the US and therefore serve as a bit of a hub in the way of high quality feed and forages, resources and research, as well as other breeders to network with.
One of my favorite MN locations has to be the MN Science Museum. First of all, Chris and I had our first date there when we met. Since then we have found great value in a membership and being able to take in new exhibits and spend time there when farm related items allow us to get out for an afternoon. It's a nice day out.
In a heavy saucepan, combine sugar with 1 cup water. Bring to a boil over high heat, swirling the pan occasionally to dissolve the sugar. Once the sugar has dissolved, boil the mixture, swirling occasionally (do not stir), until it has a medium amber color and honey-like consistency. (If the mixture seems to be browning too fast, lower heat to medium.) Remove pan from heat and stir in butter and salt. Slowly pour in goat's milk (mixture will bubble furiously) and stir until smooth. Let the cajeta cool slightly before serving.


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Smith, Scharping and the Huskies are ready for the challenge, though. "I think we're as good as any team out there," Smith said. "Playing against these guys, I see them as equal. ...It's going to be a challenge. For us to go up against them, It's a challenge, but it's going to be the right challenge and it's the right challenge for us because we have a great team. "Seeing us at Nebraska last year....We're going to go out there relentless, smart, tough. It's going to be a ball game. I don't think anybody in this country thinks otherwise. If they do, well then, get ready to watch." The Huskies are coming off a 2017 season, in which they finished with a 8-5, 6-2 Mid-American Conference record.
On offense, the Huskies return quarterback Marcus Childers, who was the 2017 conference freshman of the year. Childers took over mid-way through the season, guiding the Huskies to a 5-2 record during their last seven games of the regular season. He completed 152 of 265 (57.4 percent) of his throws for 1674 yards and 16 touchdowns. Childers was also a viable option on the ground, finishing as NIU's second-best rusher with 609 rushing yards and five rushing touchdowns on 143 carries. NIU coach Rod Carey made it clear Childers was the No. 1 guy at the end of last season.
Asked what the ceiling is, Scharping said there is none. "You see our opponents and you see what we're up against," he said. "We want to prove ourselves that we're one of the best teams in the country." NIU opens the 2018 regular season Saturday September 1 at Iowa.
DeKALB – Northern Illinois All-American defensive end Sutton Smith wore a red NIU polo with a matching hat and a full-smile Monday inside the Yordon Center.
Joined by teammate Max Scharping, both had reason to be happy with NIU football officially beginning spring practice Tuesday morning. The Huskies will conduct 15 total spring practices, including the annual Huskie Bowl scheduled on Saturday April 28.
These practices will be crucial for NIU, which faces a stacked schedule in 2018 with non-conference opponents that include Iowa, Utah, Florida State and BYU, along with three MAC-bowl contenders from last season in Akron, Ohio and Toledo.


Factor XI or plasma thromboplastin antecent is one of the enzymes of the coagulation cascade.
Factor XI (FXI) is produced by the liver and circulates as a homo-dimer in its inactive form.
Deficiency of factor XI causes the rare Haemophilia C; this mainly occurs in Ashkenazi Jews and is believed to affect approximately 8% of that population.
Deficiency of factor XI is associated with a bleeding tendency, but the correlation between the plasma level and the severity of the haemorrhagic manifestations is poor.
Factor XI is a serine protease enzyme, encoded by a gene located on chromosome 4 and synthesized in the liver.
The principal inhibitor of activated factor XIa in the circulation is alpha 1-antitrypsin.
Factor XI deficiency is a very rare bleeding disorder, occurring in an estimated one in 100,000 Americans.
Factor XI is a protein that helps blood clot and is activated by thrombin.
If you have factor XI deficiency, chances are your symptoms are milder than those of either hemophilia A or hemophilia B, and there may be no strong relationship between your factor XI levels and bleeding complications.
As in human beings, factor XI deficiency in Holstein cattle is inherited as an autosomal trait.
Prevalence and inheritance of factor XI (plasma thromboplastin antecedent) deficiency in cattle.
Factor XI is a 160,000 Dalton glycoprotein proenzyme that is produced by the liver and megakaryocytes.
Hereditary factor XI deficiency, referred to as Hemophilia C is transmitted as an autosomal recessive mutation.
The bleeding associated with factor XI deficiency is generally not as severe as that found with hemophilia A or B.
Factor XI is a plasma glycoprotein which circulates in a non-covalent complex with high molecular weight kininogen (1).
Factor XI circulates as a zymogen and requires proteolytic activation to acquire serine protease activity.
Factor XIa consists of two NH -terminal derived heavy chains, and two COOH-terminal derived light chains, all of which are held together by disulfide bonds.
Production and therapeutic use of a factor XI concentrate from plasma.
Factor XI deficiency is an uncommon bleeding disorder usually manifested by excessive bleeding after surgery or trauma.
We describe the efficacy and safety of a new factor XI concentrate produced from human donor plasma by a modification of the method used for antithrombin III concentrate.
The mean recovery of factor XI in the circulation measured on 62 occasions was approximately 91% of the injected dose, and the mean half-disappearance-time was 52 h.
Factor XI by thrombin in the intrinsic pathway (5).
Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces.
Factor XI deficiency is an inherited bleeding disorder observed in Holstein-Friesian cattle worldwide.
As a result, little testing for Factor XI has occurred in the U. despite its presence here at a frequency that could be as high as the 7 percent currently estimated for Canadian Holsteins.
In the case of the human deficiency of Factor XI, which is found in a variety of ethnic groups around the world, at least 15 separate mutations have been identified as causes of the bleeding symptoms.
Individuals with this factor deficiency are prone to easy bruising, nosebleeds, or blood in their urine.
By a physician knowledgeable about the disorder, by measuring the Factor XI level in the blood, and by identifying a specific PTA gene mutation.
By measuring Factor XI level in blood or identifying a known mutation.
Lysis of a thrombin induced clot in the presence or absence of anti-factor XI antibodies or PCI.
on clot lysis of inhibition of factor XI and TAFI.
Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene.
Factor XI (pronounced Factor 11) Deficiency is an inherited bleeding disorder.
In Factor XI Deficiency, the level of Factor XI in the blood is lower than normal.
For reasons that are not well understood, the use of Factor XI concentrate raises the risk of blood clots forming in the bloodstream where they are not wanted (thrombosis).
PhosphorImager analysis revealed 40%, 15%, and 4% conversion of factor XI to heavy and light chains, respectively, in the lanes of the upper panel, and 16%, 8%, and 1% conversion in the lanes of the lower panel.
Factor XII-independent activation of factor XI in plasma: effects of sulfatides on tissue factor-induced coagulation.
Prothrombin is a cofactor for binding of factor XI to the platelet surface and for platelet-mediated factor XI activation by thrombin.
Sometimes factor testing may be done on a patient with a known deficiency to monitor the factor deficiency, and to evaluate the effectiveness of treatment.
Factor testing may be done if an inherited factor deficiency is suspected, especially when bleeding episodes begin early in life or when a close relative has an inherited factor deficiency.
Factors may be decreased because of: DIC, liver disease, uremia, some cancers, bone marrow disorders, exposure to snake venom, a Vitamin K deficiency, anticoagulation therapy, an accidental ingestion of the anticoagulant warfarin, or due to blood transfusions (stored units of blood lose some of their clotting factors).
Gene: Factor XI deficiency in caused by mutations in the F11 gene, which is located at 4q35.
It encodes for the protein Factor XI or plasma thromboplastin antecendent (PTA), which is involved in blood coagulation.
Use of Plasma concentrate of Factor XI may be necessary for major surgery.
Background: Factor XI (FXI) deficiency is an autosomal disorder that may be associated with bleeding.
FXI remains on the surface and activates factor IX in plasma.
This results in no measurable FXI in the homozygous state and a measurable factor XI level that is lower than the expected 50% in the heterozygous state.
Factor inhibitors are not normally present in plasma.
Factor inhibitor assays are ordered in response to clinical impression, and are performed periodically on individuals who have inhibitors and are receiving therapy.
Factor II deficiency is a disorder of blood clotting (coagulation) resulting from a deficiency of prothrombin.
What is Factor XI Deficiency (Hemophilia C)? -- Bleeding Disorders Association of Northeastern New York (BDANENY), Inc.
The incidence of factor XI deficiency is 1 in 100,000, though it occurs more frequently among members of some ethnic groups.
There are at least three different known genetic changes associated with factor XI deficiency; these vary in their effect on bleeding.
Factor XI deficiency is usually diagnosed after injury-related bleeding, and symptoms tend to be mild.
Factor XII deficiency, also a cause of a prolonged aPTT, is not associated with bleeding (and possibly associated with thrombosis) and therefore should not be treated with plasma or any other agent to prevent bleeding.
Dzik WH, Arkin CF, Jenkins RL: Transfer of congenital factor XI deficiency from a donor to a recipient by liver transplantation.
Zivelin A, Bauduer F, Ducout L, et al: Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene.
Factor XI deficiency with a novel homozygous mutation Trp599Arg near the C-terminal region.
Factor XI (PTA) deficiency in an English-American kindred.
We have recently shown that Factor XI deficiency in Holstein cattle is caused by a mutation that leads to a shortened protein that lacks biological activity.
As a result, little testing for Factor XI has occurred in the U. where its frequency could be as high as the 7 percent currently estimated for Canadian Holsteins.
ADHIS adopts codes for Factor XI ADHIS recognised Factor XI as a single locus genetic defect that exists in Holstein cattle in 2003.
In the case of Factor XI, the carrier animal does sometimes exhibit signs of deficiency and furthermore is able to be identified by a blood test.
The genetics show that there is a simple but effective way of reducing the incidence of Factor XI deficiency in the national herd - that is to reduce the use of carrier bulls to a minimum, and eventually the number of carrier cows will be negligible.
Factor XI Although factor XI deficiency is a rare bleeding disorder with only 500 affected individuals identified nationally in the United Kingdom, it is very common in Ashkenazi Jewish people.
Not only would this provide better care for affected individuals, but in the process of screening, blood samples could be stored for genetic analyses and studies of the haemostatic process in relation to factor XI.
Acquired factor XI deficiency in systemic lupus erythematosus.
The low factor XI levels were not due to a classical coagulation inhibitor, but to a plasma factor (probably an immunoglobulin) that selectively bound factor XI.
The factor XI deficiency improved after treatment with corticosteroids.
Thus it is possible that in SLE immune complexes may bind clotting factors making them unavailable for use in the coagulation cascade.
Factor XI deficiency is another inherited bleeding disorder, which affects both males and females, and which is rare except in some ethnic groups.
Many people with Factor XI deficiency do not experience bleeding problems, but some do, particularly after surgery or trauma.
When treatment is needed, the patient's Factor XI level can be raised by transfusion of fresh frozen plasma or Factor XI concentrate.
PARIS, FRANCE -- July 9, 2001 -- Factor XI is increased in women with severe coronary artery disease (CAD), investigators reported at the Eighteenth Congress of the International Society on Thrombosis and Haemostasis (ISTH).
The study was designed to investigate the role of prothrombotic risk factors which are believed to be important in cardiovascular disease among women and to dissect the interaction of coagulation factor risk factors with those of other known risk factors.
Although one study has noted high factor XI levels in relation to deep-vein thrombosis, this is the first study to examine this association in arterial disease and particularly in women with CAD."


Several examples have always illustrated how access to large numbers of biospecimens and associated data plays a pivotal role in the identification of disease genes and the development of pharmaceuticals. Hence, allowing researchers to access to significant numbers of quality samples and data, genetic biobanks are a powerful tool in basic, translational and clinical research into rare diseases. Recently demand for well-annotated and properlypreserved specimens is growing at a high rate, and is expected to grow for years to come. The best effective solution to this issue is to enhance the potentialities of well-managed biobanks by building a network. Here we report a 5-year experience of the Telethon Network of Genetic Biobanks (TNGB), a non-profit association of Italian repositories created in 2008 to form a virtually unique catalogue of biospecimens and associated data, which presently lists more than 750 rare genetic defects. The process of TNGB harmonisation has been mainly achieved through the adoption of a unique, centrally coordinated, IT infrastructure, which has enabled (i) standardisation of all the TNGB procedures and activities; (ii) creation of an updated TNGB online catalogue, based on minimal data set and controlled terminologies; (iii) sample access policy managed via a shared request control panel at web portal. TNGB has been engaged in disseminating information on its services into both scientific/biomedical - national and international - contexts, as well as associations of patients and families. Indeed, during the last 5-years national and international scientists extensively used the TNGB with different purposes resulting in more than 250 scientific publications. In addition, since its inception the TNGB is an associated member of the Biobanking and Biomolecular Resources Research Infrastructure and recently joined the EuroBioBank network. Moreover, the involvement of patients and families, leading to the formalization of various agreements between TNGB and Patients' Associations, has demonstrated how promoting Biobank services can be instrumental in gaining a critical mass of samples essential for research, as well as, raising awareness, trust and interest of the general public in Biobanks. This article focuses on some fundamental aspects of networking and demonstrates how the translational research benefits from a sustained infrastructure.
This article was published online in the Orphanet Journal of Rare Diseases and is free to access.


Are your employees falling sick often? If yes, they may be suffering fromSick Building Syndrome (SBS). SBS is caused by poor indoor air quality, whereby bad air is being circulated within the building by the air conditioning system.
When workers are ill, productivity rate falls while medical expenditure for the employers go up. This situation can be minimized by introducing certain scents and fragrances in the office (especially those with natural healing, antiseptic, antibacterial properties). Hence, companies can use scent marketing machines to create a healthier working environment and improve the mental alertness and productivity of staff. Besides, the scents can also leave a lasting impression upon customers and visitors.
For mental clarity and stimulation the best oils are Rosemary, Peppermint, Lemon, Basil, Ginger, and Cypress. These oils can help with fatigue and lack of focus.
A pleasant but subtle scent that increases work productivity by stimulating employees' senses.
Employees will experience positive feelings through such an environment because of the positive image it represents. Therefore, work performance will also be positive.


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Air New ZealandAirlinesHeadlinesMaintenance
Air New Zealand expects 787-9 engine checks to be completed in 12 months
written by australianaviation.com.au August 24, 2018
An Air New Zealand Boeing 787-9 at Auckland Airport. (Andrew Aley)
Air New Zealand expects all necessary inspections for its Rolls-Royce Trent 1000 engines that power its Boeing 787-9 fleet will be completed within the next 12 months.
In the meantime, the airline plans to dry lease three widebody aircraft as cover for grounded 787s awaiting engine checks alongside schedule changes on certain routes in order to offer "better reliability" for passengers, Air New Zealand chief executive Christopher Luxon said during the company's 2017/18 full year results presentation on Thursday.
"We continue to work closely with Rolls-Royce to limit the impact of the global Trent 1000 engine issues but we do recognise that we need to deliver greater schedule certainty for our customers going forward," Luxon said.
Over the recent summer holidays and again earlier in 2018, Air New Zealand wet-leased aircraft as cover for its Boeing 787-9s being grounded due to regulators calling for inspections on the Rolls-Royce Trent 1000 engine.
However, as the mandatory engine inspections have taken longer than previously expected to complete, Air New Zealand sought aircraft for dry lease, where they are operated by the airline's own pilots and cabin crew.
In May, Singapore Airlines Boeing 777-200ER 9V-SVL was registered on the New Zealand Civil Aviation register as ZK-OKI. The aircraft, which is configured in a two-class configuration across business and economy, has been scheduled to operate Auckland-Honolulu between July and September and then Auckland-Perth in September and October.
Air New Zealand has also dry leased EVA 777-300ER B-16717 as further cover. The aircraft, which has a business, premium economy and economy cabin, has been registered as ZK-OKT and will operate on the Auckland-Vancouver, and Auckland-Nadi routes over August and September, as well as between Auckland and Honolulu over September-October, according to the airline's website.
The company said in its full year results the three dry lease aircraft would comprise two 777-200s and one 777-300.
Meanwhile, schedule changes including retiming flights to Tokyo Haneda and reducing frequencies to Buenos Aires and yet-to-commence flights to Taipei.
This would be the equivalent of freeing up two widebody aircraft in order to allow for a bit more schedule certainty for passengers.
Rolls-Royce ramping up MRO capacity for Trent 1000 inspections
Regulators have called for more regular checks on Rolls-Royce Trent 1000 engines' intermediate pressure compressor rotor blades. de to some durability issues.
Rolls-Royce said earlier in August the peak number of aircraft on ground reached about 50 earlier in 2018 and was gradually being reduced as the company ramped up its maintenance, repair and overhaul (MRO) capacity to cope with the increased inspections.
"We have the situation with each customer's engines plotted out over the next 12 to 18 months and that is a dynamic situation but we are working very closely with them on that," Rolls-Royce chief executive Warren East East said during Rolls-Royce's first half results presentation on August 2.
Luxon said the inspections were taking longer than initially expected.
"We were recently notified that there is likely to be a delay in getting some of our engines back," Luxon said.
"Just to be clear, the delay is not in relation to any new technical issues. Rather it is because the timing of the engine maintenance program has shifted.
The Air New Zealand chief executive described the situation as a "global production and parts backlog".
"Obviously this is an issue affecting a global fleet and as Rolls-Royce deal with that through their production facilities they have got a throughput issue and a challenge," Luxon said.
"And so when we send the engines up there for their maintenance checks and servicing, it's taking longer for them to get through the shop and that's ultimately what's leading us to reset now."
"Based on everything that we know today and the guidance that we're giving, we expect to be able to get those engines through those shops in the next 12 months."
Boeing 777-300ER B-16717 is now operating for Air New Zealand as ZK-OKT. (Wikimedia Commons/Kohei Kanno)
Boeing 777-200ER 9V-SVL is now operating for Air New Zealand as ZK-OKI. (Wikimedia Commons/RHL Images)
Air New Zealand orders more Airbus A321neos
In other Air New Zealand fleet news, the airline said it had signed a commitment with Airbus for seven A321neos for its domestic operations.
The commitment was separate to the existing order for 13 Airbus narrowbodies, comprising seven A321neos and six A320neos that will begin to arrive in the coming months and be deployed on trans-Tasman and Pacific Islands routes.
The use of the larger A321neo on its domestic network was raised as a possibility at the airline's investor day in June.
Air New Zealand chief financial officer Jeff McDowall said the domestic A321neos would offer efficient growth through upgauging and deliver cost efficiencies.
"We've been growing our domestic business very strongly over the past five years," Air New Zealand chief financial officer Jeff McDowall said.
Currently, Air New Zealand has 17 A320ceos operating in its home market, where the airline has increased capacity by about 20 per cent since 2016 through increased utilisation.
The domestic fleet would be expanded to 20 aircraft in 2019, with the temporary transfer of A320ceos currently used on the trans-Tasman routes redeployed into the New Zealand market.
The fleet will stay at 20 aircraft from the the time domestic-configured A321neos start arriving in 2020 and replace A320ceos on a one-for-one basis until all seven have been delivered in 2024.
Air New Zealand said this would enable seat growth of about 25 per cent from 2018 to 2024.
A slide outlining Air New Zealand's domestic fleet plan until 2024. (Air New Zealand)
Air New Zealand reports improved 2017/18 net profit
As far as the bottom line for the previous financial year was concerned, Air New Zealand posted net profit of NZ$390 million for the 12 months to June 30 2018, up 2.1 per cent from NZ$382 million from the prior corresponding period.
Revenue rose 7.4 per cent to NZ$5.49 billion, the company said in a regulatory filing to the Australian Securities Exchange and New Zealand stock exchange on Thursday. (Air New Zealand is listed on both sides of the Tasman.)
In recent years, Air New Zealand has been in expansion mode, with long-haul services to the Americas and Asia such as Buenos Aires, Houston and Singapore launched as the airline sought to take advantage of strong growth in visitor numbers to New Zealand.
There has also been capacity growth in its home market as it upgauged regional routes from 19-seat Beechcraft turboprops to 50-seat Q300s or 68-seat ATR 72s. There has also been more jet services added on main trunk routes.
And there is more to come, with new services to Chicago and Taipei due to commence in November. Closer to home, Air New Zealand is also ramping up capacity on trans-Tasman routes from the end of October, when its alliance with Virgin Australia ends.
(Air New Zealand announced in April it would walk away from the seven-year joint-venture with Virgin Australia, preferring to go it alone on the Tasman as it sought to encourage more Australians travelling to North America and South America to travel via its Auckland hub. The airline has also signed a codeshare agreement with Qantas for access to Australian domestic destinations it doesn't fly to.)
The slender improvement in full year profit was achieved amid a 25 per cent increase in oil prices, which lifted Air New Zealand's total fuel bill for 2017/18 to NZ$160 million, or 19 per cent.
Meanwhile, earnings before taxation, which the company regarded as the best indication of financial performance, rose 2.5 per cent to NZ$540 million, compared with NZ$527 million a year ago.
"This is an impressive financial result, driven by strong revenue growth across the airline's key markets, as well as continued focus on sustainable cost improvement, despite significantly higher fuel prices," Air New Zealand chairman Tony Carter said in a statement.
Looking ahead, Air New Zealand has guided the market to expect underlying earnings before taxation in the range of NZ$425 million to NZ$525 million for 2018/19.
The forecast did not include the estimated $30 million to $40 million impact from the Rolls-Royce Trent 1000 engine issues that have impacted the 787-9 fleet. Air New Zealand said the engine troubles on its 787-9 fleet did not have a material impact on its 2017/18 earnings.
Air New Zealand's capacity guidance showed available seat kilometres (ASK) was expected to grow between four and six per cent in the current year.
The airline planned to increase capacity in the domestic market between three and five per cent as it added extra jet flights to Dunedin and Queenstown, and expanded in some regional ports.
Its Tasman and Pacific Islands network was forecast to expand by seven to nine per cent, which accounted for the new flying schedule to Australia and the introduction of the Airbus A321neo into those markets.
And international long haul ASKs were expected to grow between three to five per cent as it started flights to Chicago and Taipei, as well as increased flying to Singapore.
"As we look forward we continue to see good demand across our key markets," Luxon said.
"Despite the higher fuel price that growth is expected to be profitable and it is aligned with our philosophy that all routes have to perform on their own merits."
The company declared a final dividend of 11 cents per share.
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Hello again from the team here at The House of Ugly Fish! We thought we'd feature these two panels for today's blog, as they perfectly show off how a pair of bespoke fused glass art pieces can work together to create a theme in a kitchen. Just take one look at the images we've included and it should be immediately obvious how well these two splashbacks match the kitchen. They really unify the look of the room, with designs that work to complement both each other and the wider décor at the same time!
When you view the two pieces together, the effect should be immediately obvious!
The central splashback features a striking flower burst style design that makes full use of the space it sits in. Leaf shaped pieces explode outwards in an incredibly vivid burst of colour. You'll be able to notice all sorts of shades and hues being utilised to their full effect, building on a base of subtle golden yellow and green inspired by the colour of the kitchen.
The second piece that sits across from it is much more subtle in comparison, but there's so much to see even with its relatively simple design! Two smaller flowers sit nestled at the edges of the piece, with a colour palette that's perfectly paired with the first splashback and the kitchen as a whole. Step closer and you'll see endless layers of subtle texture underneath the stylish accents that sit in each corner.
If you love the way that these two pieces look together, why not go for the same approach in your own kitchen? We here at The House of Ugly Fish are specialists when it comes to providing bespoke fused glass art that can transform any space in your home. You're guaranteed to get something unique and personalised, so make sure you don't wait to get in touch via the details on our contact page. It's as easy as picking up the phone for a chat or dropping us an email.


One Marvel fan imagines the effect of Thanos' victory in Avengers: Infinity War at Sesame Street. The beginning of the culmination of everything that has transpired in the MCU since 2008's Iron Man, the Joe and Anthony Russo-directed movie set up the stage up for Earth's Mightiest Heroes' final battle against Thanos in next year's Avengers 4. Not much is known regarding the narrative of the Phase 3 capper, but it's expected to see the Avengers doing everything in their power to restore peace in the universe.
Currently, the galaxy is in shambles after Thanos fulfilled his goal of balancing the universe by killing half of life in the universe. Fans have previously discussed how other surviving characters in the MCU like Aunt May or Valkyrie may have dealt with the outcome of the galactic genocide, but one fan visualizes what it's like at Sesame Street.
Big Bird has to think about that for a moment. He went missing one time, when he was a blue bird in a circus, but his friends found him and brought him home. But something about Alan's face tells Big Bird that this isn't the kind of missing where your friends can find you.
Towards the end, Chris added that aside from Alan, there are countless more people who disappeared after the snap, making Big Bird sadder. And although this specific story isn't canon to the MCU, it gives fans a good perspective of the full impact of Thanos defeating the Avengers. What people saw at the end Infinity War was just a fraction of the chaos that the galactic genocide caused. At least the Avengers and their allies knew what was happening, but it's infinitely more terrifying for people who didn't have a clue about what just happened. Aside from human and alien beings, the deadly click also wiped out half of plant and animal life in the universe which means that even in the most remote areas, the effect of the snap was felt.
Marvel Studios is putting off dealing with the aftermath of Avengers: Infinity War until next year's Avengers 4. Aside from the post-snap sneak peek that fans saw at the end-credit scene for Ant-Man & The Wasp, no one really knows the full consequences of the snap, perhaps even Thanos as the Russo brothers recently implied that there's a high price to pay for using all the Infinity Stones at the same time. MCU is usually good with showing audience different perspectives of a single inciting incident (case in point: the Sokovia incident in Avengers: Age of Ultron sparked Baron Zemo's revenge job against the Avengers in Captain America: Civil War). But with such a broad scope of affected areas, it's curious how they'll be able to do that with regard to Thanos' mass murder.