text:
Ülkenizi Seçiniz (Select Your Country)
Türkiye (Turkey) Almanya (Germany) Amerika Birleşik Devletleri (United States) Arnavutluk (Albania) Avustralya (Australia) Avusturya (Austria) Azerbaycan (Azerbaijan) Belarus (Belarus) Belçika (Belgium) Birleşik Arap Emirlikleri (United Arab Emirates) Birleşik Krallık (United Kingdom) Bolivya (Bolivia) Bosna Hersek (Bosnia and Herzegovina) Brezilya (Brazil) Bulgaristan (Bulgaria) Çek Cumhuriyeti (Czech Republic) Çin (China) Danimarka (Denmark) Ermenistan (Armenia) Finlandiya (Finland) Fransa (France) Gürcistan (Georgia) Hırvatistan (Croatia) Hindistan (India) Hollanda (Netherlands) Hong Kong (Hong Kong) Irak (Iraq) İrlanda (Ireland) İspanya (Spain) İsveç (Sweden) İsviçre (Switzerland) İtalya (Italy) İzlanda (Iceland) Jamaika (Jamaica) Japonya (Japan) Jersey (Jersey) Kanada (Canada) Karadağ (Montenegro) Katar (Qatar) Kazakistan (Kazakhstan) Kenya (Kenya) Kıbrıs (Cyprus) Kırgızistan (Kyrgyzstan) Kore Cumhuriyeti (Korea, Republic of) Kore Demokratik Halk Cumhuriyeti (Korea, Democratic People's Republic of) Kosova (Kosovo) Kutsal Görüş (Vatikan Şehir Devleti) (Holy See (Vatican City State)) Kuveyt (Kuwait) Litvanya (Lithuania) Lübnan (Lebanon) Lüksemburg (Luxembourg) Macaristan (Hungary) Makedonya, Eski Yugoslav Cumhuriyeti (Macedonia, the Former Yugoslav Republic of) Maldivler (Maldives) Meksika (Mexico) Mısır (Egypt) Moldova Cumhuriyeti (Moldova, Republic of) Monako (Monaco) Nepal (Nepal) Norveç (Norway) Özbekistan (Uzbekistan) Pakistan (Pakistan) Peru (Peru) Polonya (Poland) Portekiz (Portugal) Porto Riko (Puerto Rico) Rusya Federasyonu (Russian Federation) Sırbistan (Serbia) Sırbistan ve Karadağ (Serbia and Montenegro) Singapur (Singapore) Slovakya (Slovakia) Slovenya (Slovenia) Sri Lanka (Sri Lanka) Suudi Arabistan (Saudi Arabia) Şili (Chile) Tayland (Thailand) Türkiye (Turkey) Türkmenistan (Turkmenistan) Ukrayna (Ukraine) Ürdün (Jordan) Yunanistan (Greece)
Dil Seçiniz (Select Language)
Iznik Mavi Cini was founded in 2002 by Mahmut Calışkan, Serap Ereyli and Ismail Kaya to produce traditional Iznik tiles, of which production ended in the 18th century and began only in the 21st century, using modern technology.
Iznik tile is known in the world's ceramic literature as the ceramic that is impossible to produce. The challenge lies in quartz -the raw material- that is present in all layers as well as the fact that an excessive amount goes to waste during shaping and firing stages. With its constant R&D efforts and design prowess, Iznik Mavi Cini works to prevent these exquisite works of art from going into oblivion, seeks to introduce them to new generations so that they can be used by future generations as well. In 2011, the Ministry of Culture and Tourism named company shareholders Mahmut Calışkan, Serap Ereyli and Ismail Kaya as the Bearers of Intangible Cultural Heritage due to their successful and original works.
İsmail Kaya
Glazing & Kilning Specialist
After starting his professional career in 1995 in a tile company in Iznik, Kaya continued as the head of his department where Iznik tile were built, glazed and fired. He had the opportunity to work with important masters up until 2002 such as Faik Kırımlı, Faruk Şahin, Fehmi Demirel and Fikret Esen. He is one of the shareholders of the Iznik Mavi Çini company founded in 2002 and works in the glazing & kilning stages of the Iznik tile production of the company.
Mahmut Çalışkan
After graduating from Eskişehir Anadolu University's Department of Mining as a mine technician, he worked as a line manager in COMAG Eskişehir and then Soil Ceramic Mine Enrichment Organization in Bilecik. Between 1997-2002, he worked as a raw material and R&D manager in a tile company in Iznik. He is one of the shareholders and technical manager of the Iznik Mavi Çini which was founded in 2002.
Serap Ereyli
After graduating from Mimar Sinan University's Department of Turkish Handcrafts and Ceramics, Ereyli worked as a tile designer and then as the head of the design department in a ceramic company. She is one of the shareholders and designer of the Iznik Mavi Cini founded in 2002. She received an honorable mention with her design at the 4th Dösim Souvenir Design Contest held by the Ministry of Culture and Tourism.
Total Square Meters
FOR THE FIRST TIME AFTER 450 YEARS, A MONO-BODY IZNIK CERAMIC WAS PRODUCED (40X80 CM)
SERAP EREYLİ, THE DESIGNER AND A SHAREHOLDER OF THE COMPANY WAS AWARDED AN HONORABLE MENTION AT THE 4TH DOSIMM SOUVENIR DESIGN CONTEST.
FIRST IZNIK CERAMIC RESTORATION WAS CARRIED OUT - BURSA GREEN TOMB
THE WORLD'S LARGEST IZNIK TILE PANEL WAS BUILT IN 2013 - KAYSERİ SQUARE
THE WORLD'S LARGEST MINIATURE IZNIK TILE PANEL WAS BUILT IN 2014– ESKİŞEHİR DEDE KORKUT MONUMENT
THE COMPANY MOVED INTO THE FACILITIES OWNED BY IZNIK MAVI CINI
THE FIRST FOREIGN IZNIK CINI RESTORATION WAS CARRIED OUT – AL-MASJİD AN-NABAWİ-MEDINA
Subscribe and we will keep you informed of new products and announcements.
Right of Withdrawal and Conditions of Return
P.D.P.L Text
Selçuk Mahallesi
Yunus Emre Sokak No:26
İznik / Bursa / Turkey
iletisim@iznikmavicini.com
Veri politikasındaki amaçlarla sınırlı ve mevzuata uygun şekilde çerez konumlandırmaktayız. Detaylar için veri politikamızı inceleyebilirsiniz. Kabul Ediyorum


text:
U-Turn Over Law on Bail To Protect Victims of Domestic Violence
Holocaust Memorial Day 2021 – be the light in the darkness
West Midlands seeks £11m to support huge community effort during lockdown
We must stay vigilant despite vaccine roll-out
Kashmiris will never give up their demand for their birth and fundamental right to self-determination at any cost Fahim Kayani
Kashmiri diaspora in the UK demand immediate suspension, & investigation of British MP Virenda Sharma in abusing his position
Gawkadal massacre: JKNF calls for shutdown on 21 January Urges world community to hold India accountable for its crimes
Strict Bail Conditions on Domestic Abuse and Sexual Violence Suspects
Fewer Than One in 10 Police Officers Fired After Gross Misconduct Finding
Debbie Abrahams MP raises concerns about human rights violations in IIOJ&K in an official letter to UK PM Boris Johnson
Diaspora Activists Call for International Action to End 73 Year-Long Indian Occupation
Washington: The World Kashmir Awareness Forum (WKA) issued the following statement in honor of Kashmir's "Right to Self Determination Day" on January 5.
"On January 5, 1949, the United Nations Commission on India and Pakistan (UNCIP) affirmed Kashmir's right to self-determination through a free and fair plebiscite. More than seven decades later, India's brutal military occupation has continuously denied Kashmiris this right.
Today, the situation in occupied Kashmir is existential. With 100,000 civilian deaths, 10,000 missing and civic, political and economic life critically suppressed, the people of Kashmir are on the brink of genocide. In a further escalation of oppressive tactics, in 2019, India imposed the longest internet blackout ever in a democracy, while engineering laws that are forcibly grabbing land and changing the demographics of the region in favour of Indian settler colonies. As recently as November 2020, India has carried out surprise raids against non-governmental organisations (NGOs), media outlets, human rights activists, political opponents and journalists.
On 'Right to Self-Determination Day,' the World Kashmir Awareness Forum (WKA) sharply condemns the Indian government's occupation of Jammu and Kashmir, and the human rights violations resulting from it. 73 years of oppression and terror have not weakened the Kashmiri peoples' commitment to self-determination. It is the responsibility of all nations who uphold democracy and human rights to champion our cause; the WKA is hopeful that the new Biden-Harris administration will take the lead in this vital work."
Facebook Twitter LinkedIn Tumblr Pinterest Reddit VKontakte WhatsApp Telegram Viber Share via Email Print
Message from President of the Islamic Republic for Pakistan On the Occasion of Pakistan Day 23 rd March, 2019
Journalists injured in election-related violence in West Bengal
Why the Left Should Argue for More Immigration – But Not Open Borders
Xi Jinping to give important speech at National Day celebrations
Children's Right to Live in the Community

redpajama_set_name: RedPajamaCommonCrawl


The SMCN0781 Countersunk neodymium magnet is made from high performance N42 NdFeB, with Nickel coating. The dimension of this item is 7/8" od × 1/8" thick with countersunk hole for #8 screw, magnetized Through Thickness, with tolerance of ±0.004" × ±0.004" × ±0.004" × ±0.004". The weight of this super strong neodymium magnet is 0.0199375 lbs. It can pull up to 10.23 lbs steel.


text:
Anorak News | Facebook Delete Unborn Baby
Facebook Delete Unborn Baby
by Anna Leach | 3rd, June 2011
AMERICA is the last place you'd expect this to happen, what with all those groups banging on about The Rights Of The Unborn Child. But, it did, and Mark Zuckerberg is to blame. Facebook deleted the profile page of an UNBORN baby.
Marriah Greene's Facebook profile was deleted without warning -despite her having 260 friends. The blame really lies with her parents – let's be honest – they thought that giving their embryo a Facebook page was the best way to update everyone of the process of her mum's pregnancy.
Father Matt Greene told ABC news:
"We weren't sure how to tell all our friends the baby was coming. We'd held off on telling people — we wanted to make sure everything was fine with the pregnancy. We thought the quickest way to tell everyone would be to use Facebook."
If getting a friend request from an unborn embryo really is the quickest way to get the news of a birth out there, there's probably some kind of communication failure going on.
Most crucially, they ignored the bit which says you need to be over 13 to start a Facebook profile.
It raises a bunch of moral issues though: is an embryo really a person? If it has toenails, is it allowed to have a Facebook profile? We hope someone is thinking about the implications.
Facebook have got more aggressive about deleting profiles it suspects are rogue. Over the past few months that has included the profile of an American Kate Middleton and Mark Zuckerberg – the insurance salesman. Both real people, both share names with famouses, both fell on the wrong side of the law.
Though maybe in this particular case, someone at Facebook just got disgusted at how icky it had all become – the parents said their child was at the "university of tummy". Get rid of it all now.
Spotter: International Business Times
Anna Leach
Posted: 3rd, June 2011 | In: Key Posts, Technology Comment | TrackBack | Permalink


Pair Late 19th Century Chinese Figural Carved Gilt-wood Panel, Very good Condition. Size: 25"T x 11"W.
The item "Pair Late 19th Century Chinese Figural Carved Panel" is in sale since Wednesday, March 6, 2019. This item is in the category "Antiques\Asian Antiques\China\Figurines & Statues". The seller is "gmg-clocks" and is located in Temple City, California. This item can be shipped worldwide.


text:
Talk about anything you want in the comments. [Author: [email protected] (Ann Althouse)]
Queen Guitarist Brian May Says COVID 'Beast' Is Still In His Body
The rock legend told his Instagram followers that "there IS life after Covid! But DO be careful … you do not want this, and neither do your family."
Tags: News, Instagram, Brian May Says
The best Canadian social media campaigns of 2021
It's that time of year again! As the new year approaches, we're looking back on the best Canadian social media campaigns of 2021. There are tons of lessons to be learned from the best brands on social media! Grab yourself some Timbiebs and a double-double, and check out our favourite social media campaigns from the past year! The best Canadian Social Media Campaigns of 2021: 1. Makeup for Melanin Girls When it comes to the cosmetics industry, BIPOC consumers struggle to feel val...
Tags: Twitter, Instagram, Youtube, Marketing, Digital, Social Media, Content Marketing, Social Media Marketing, Canada, Justin Bieber, Starbucks, Globe, Hulu, Calgary, Influencer Marketing, Richmond
The moon hangs on a tree...
... at 7:22 a.m. on the first day of winter. [Author: [email protected] (Ann Althouse)]
Tags: Photography, Law, The moon, Ann Althouse
How Instagram nano influencers make money with under 10,000 followers
Jen Lauren is a "nano" influencer on Instagram and YouTube.Jen Lauren "Nano" influencers are generally defined as having fewer than 10,000 followers on Instagram. And some have turned their social-media hobbies into part-time jobs or side hustles. Here's how several creators earn money as nano influencers on Instagram and other platforms. See more stories on Insider's business page. "Nano" influencers may only have a few thousand followers, but that's not keeping them from turning...
Tags: Media, Instagram, Youtube, Advertising, Trends, Nano, Creators, Ncaa, Influencers, Broder, Lauren, Tech Insider, Sydney Bradley, Khadijah Lacey Taylor, Jen Lauren, Nano influencers
Chris Noth Dropped From The Equalizer Following Sexual Assault Allegations
CBS has dropped Chris Noth from its reboot of "The Equalizer" TV show in the wake of multiple sexual assault allegations against the actor. Noth previously co-starred opposite Queen Latifah on the crime drama series as William Bishop, an old friend of Robyn McCall (Latifah) and her former handler at the CIA who continues to aid her in her newfound career as a justice-seeking vigilante.Universal Television and CBS announced the news in an official statement (via TVLine), reading, "Chris Noth will...
Tags: Hbo, Television, Movies, News, Instagram, Davis, Cbs, Cia, Miranda, Lily, Cynthia Nixon, Nixon, Parker, Latifah, Kristen Davis, Carrie
How to create an influencer media kit to get brand deals
Marina MogilkoMarina Mogilko Social-media influencers use media kits to pitch themselves to brands. These documents often provide metrics, and some kits also include pay rates. We spoke with a dozen creators who shared the exact media kits they use. See more stories on Insider's business page. Many social-media creators rely on brand deals as their main source of income.Influencers can offer advertisers a range of content types — like in-feed posts on Instagram, a 30-second TikTok, or a...
Tags: Media, Instagram, Youtube, Advertising, Trends, Influencers, Tech Insider, Roberto Blake, Josh Richards, Tiktok, YouTube Brands, Amanda Perelli, Marina Mogilko, Mogilko, Macy Mariano, Jade Darmawangsa
5 Free 4×6 Photo Prints From Walgreens
https://i.dansdeals.com/wp-content/uploads/2018/03/11113702/535px-Walgreens_Logo.svg_-674x150.png
Tags: Deals, Photos, Walgreens, Free Stuff
10 things in tech you need to know today
Hi there. Oracle is buying medical-records giant Cerner, and SpaceX is launching human muscle cells into space. Let's get to it.If this was forwarded to you, sign up here. Download Insider's app – click here for iOS and here for Android. Larry Ellison, Oracle's founder.Robert Galbraith/Reuters 1. Oracle is buying medical-records giant Cerner. The $28 billion deal — which is nearly twice as big as Microsoft's $16 billion bid for Nuance Communications — dwarfs a lot of the work t...
Tags: Google, Amazon, Spacex, Elon Musk, UK, New York, London, Instagram, Microsoft, California, US, America, Newsletter, Trends, Tech, Tesla
Have Arsenal striker Pierre-Emerick Aubameyang's entourage already revealed his next destination?
Aubameyang out in the cold Stripped of the Arsenal captaincy. Training on his own. It has been one hell of a fall from grace for Pierre-Emerick Aubameyang in the last fortnight, coinciding with an upturn in the Gunners form that has seen them win three games on the bounce.After a disciplinary breach, allegedly returning from France a day late, the future looks bleak for the Gabon star, with no indication that he will be reintegrated into the first team any time soon. Arsenal announced that f...
Tags: Instagram, France, Sport, Soccer, Liverpool, Arsenal, Mikel Arteta, Gabon, San Siro, Pierre Emerick Aubameyang, Sunderland Manchester United, Pierre Aubameyang, Charlie Patino, Vlahovi, Willy Aubameyang, AC Milan Willy
2021-12-21 SCRIMMAGE MEET-WMC Indoor Track
SCRIMMAGE MEET-western maine conference – 12/21/2021USM Licensed to Down East Sports Timing – Contractor License HY-TEK's Meet Manager 12/21/2021 09:41 PM SCRIMMAGE MEET-western maine conference – 12/21/2021 USM Results Girls 55 Meter Dash =================================================================================== Name Year School Seed Finals H# Points =================================================================================== Finals 1 Abigail Jacobson 10 GREE 8.00 1 2 ...
Tags: Photos, Sport, Running, Poland, Gree, Ian Moore, Freeport, WMC, YHS, Sam Morris, Luke Jackson, Myles Brown, Christopher Livingston, Freeport High School, Greely High School, Steven Jiang


text:
ADVANCED CASE SEARCH
An affiliate of the U.S. Chamber of Commerce
NEWS ALERT:
U.S. Supreme Court agrees with U.S. Chamber that the FOIA exemption for "confidential" business information provided to the government is not limited to information that would cause competitive harm if disclosed
Chamber of Commerce, Murray Energy Corporation, et al. v. EPA (2015 Ozone NAAQS)
Tab Group
Merits Stage
Abeyance lifted
Click here to view the order.
Case held in abeyance
U.S. Chamber and coalition file lawsuit challenging EPA's unprecedented ozone regulations
The U.S. Chamber of Commerce -- joined by other national business groups including the National Association of Manufacturers, American Petroleum Institute, Utility Air Regulatory Group, Portland Cement Association, American Coke and Coal Chemicals Institute, Independent Petroleum Association of America, National Oilseed Processors Association, and American Fuel and Petrochemical Manufacturers -- filed a petition for review in the U.S. Court of Appeals for the D.C. Circuit today to challenge the Environmental Protection Agency's (EPA) rule lowering the National Ambient Air Quality Standard (NAAQS) for ground-level ozone to 70 parts per billion (ppb).
"The EPA set an unattainable mandate with this new ozone standard that will slow economic growth opportunities," said William Kovacs, senior vice president, Environment, Technology & Regulatory Affairs for the U.S. Chamber of Commerce. "This new standard could halt progress in communities across the country as businesses are forced to slow expansion plans and outside development looks to other regions. The EPA has created a web of regulations that makes it almost impossible for businesses to succeed in this already tough economic climate."
"Through no fault of their own, many communities have yet to meet EPA's 2008 ozone standard, making it almost impossible for them to realistically meet the new standard unless they make painful decisions that the public will likely not accept," said Karen Harbert, president and CEO of the U.S. Chamber's Institute for 21st Century Energy. "As our 'Grinding to a Halt' series demonstrated, the EPA's new rule 'moves the goalposts' on states and communities working to achieve the 2008 rule. Moreover, numerous areas with growing populations and high levels of background ozone simply have no means of complying, and will be unfairly punished by EPA as a result."
Leading up to this new regulation, the U.S. Chamber actively engaged local communities through forums examining how a lower ozone standard would threaten local jobs and economic growth. Panel discussions included government officials, business leaders and local Chambers of Commerce.
The Chamber's Institute for 21st Century Energy Grinding to a Halt reports provide an in-depth look at how EPA's tightened ozone standards could halt transportation funding and permitted. The series includes snapshot looks at the impact of the new regulations on Washington, D.C., Las Vegas, Denver, Dallas-Fort Worth, and Southern California.
James R. Bieke, Roger R. Martella, and Joel F. Visser of Sidley Austin LLP served as co-counsel for the amici in this case.
Petition for Review -- U.S. Chamber, et al. v. EPA (2015 Ozone NAAQS).pdf
U.S. Chamber Motion to Intervene -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
Briefing Schedule Order -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
Joint Opening Brief of Industry Petitioners -- U.S. Chamber, et al. v. EPA (2015 Ozone NAAQS).pdf
Opening Brief of State Petitioners -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
Opening Brief of Public Health and Environmental Petitioners -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
National Association of Home Builders Amicus Brief -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
American Thoracic Society and American Lung Assn. Amicus Brief -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
Respondent EPA's Brief -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
Brief of Industry Respondent-Intervenors -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
Joint Reply Brief of Industry Petitioners -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
Final Joint Opening Brief of Industry Petitioners -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
Final Brief of Industry Respondent-Intervenors -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
Final Joint Reply Brief of Industry Petitioners -- Murray Energy Corporation v. EPA (2015 Ozone NAAQS).pdf
Order re Abeyance -- Murray Energy Corporation v. EPA (D.C. Circuit).pdf
Order Lifting Abeyance -- Murray Energy Corporation v. EPA (D.C. Circuit).pdf
Movement through the Court System
Case Status: Pending
Docket Number: 15-1385 (consolidated with Nos. 15-1392, 15-1490, 15-1491, and 15-1494)
Oral Argument Date: December 18, 2018
National Ambient Air Quality Standards (NAAQS)
Clean Air Act (CAA)
Administrative Law & Government Litigation
Ozone NAAQS Litigation Group, et al. v. EPA
American Lung Association, et al. v. United States Environmental Protection Agency, et al.
Financial Litigation
Food, Drug & Health
Forum Shopping
Government Litigation
Tax Litigation
© 2017 U.S. Chamber of Commerce 1615 H Street N.W. Washington, DC 20062-2000 All Rights Reserved.


text:
Q: FAILED TO CONNECT TO /127.0.0.1:443 - ANDROID STUDIO i have this kind of problem when i try to run my app project in android studio it keeps give me an error "failed to connect to /127.0.0.1:443". im using local ip for that. but when i try using 192.168.1.10 or 10.0.2.2 it doesn't work too.
this is my retro code
public class RetroServer {
private static final String baseURL = "https://127.0.0.1/laundry/";
private static Retrofit retro;
public static Retrofit konekRetrofit(){
    if(retro == null){
        retro = new Retrofit.Builder()
                .baseUrl(baseURL)
                .addConverterFactory(GsonConverterFactory.create())
                .build();
    }
    return retro;
}

in my retro code there's 2 of this symbols }}
and this is my androidmanifest.xml code
<uses-permission android:name="android.permission.INTERNET"/>
<uses-permission android:name="android.permission.ACCESS_NETWORK_STATE" />
<application
    android:usesCleartextTraffic="true"
    android:allowBackup="true"
    android:icon="@mipmap/ic_launcher"
    android:label="@string/app_name"
    android:roundIcon="@mipmap/ic_launcher_round"
    android:supportsRtl="true"
    android:theme="@style/Theme.Laundry">
    <activity
        android:name=".Activity.MainActivity"
        android:exported="true"
        tools:ignore="MissingClass">
        <intent-filter>
            <action android:name="android.intent.action.MAIN" />
            <category android:name="android.intent.category.LAUNCHER" />
        </intent-filter>
    </activity>
</application>

if you guys can help me with this problem, thank you so much

A: Can you do simple test in your emulator.
From your emulator.
Can you open your browser. After that, open your URL. (10.0.2.2)
If everything good.
Then you need to setup network_config in your android manifest.
Please check https://developer.android.com/training/articles/security-config
<?xml version="1.0" encoding="utf-8"?>
<network-security-config>
    <domain-config cleartextTrafficPermitted="true">
        <domain includeSubdomains="true">10.0.2.2</domain>
    </domain-config>
    <base-config cleartextTrafficPermitted="false" />
</network-security-config>

A: If you are running in localhost you should use http://10.0.2.2:8080/ as a base url, you need to specify the port, otherwise it won't work.

redpajama_set_name: RedPajamaStackExchange


text:
Lake Pepin Fish and the Missing Rapids of the Mississippi River Gorge
We're continuing the celebration of World Fish Migration Day with a look at how restoring the Mississippi Gorge will not only bring St. Anthony Falls back to life, but migratory fish as well.
Olivia Dorothy | May 23, 2018
Guest blog by Mike Davis of Minnesota Department of Natural Resources for our continued celebration of World Fish Migration Day.
Lake Pepin is a 23 mile long riverine lake in the Mississippi River created by the delta of its tributary, the Chippewa River of Wisconsin. Pepin is the widest place on the entire Mississippi River and at one time reached from the Chippewa to the city of St. Paul, MN and within about 10 miles of the foot of the rapids that extend upstream to St. Anthony Falls. By the 1800's St. Anthony Falls had eroded upstream far enough to leave around 6 miles of prime spawning habitat for fish species dependent on rapids for spawning. The 60 mile run upstream to these rapids was an easy trip on a free flowing river for the fish of Lake Pepin and the river in between.
Residents around Lake Pepin in the 1800's reported being awakened at night by the splashing of thousands of paddlefish feeding at the surface, probably targeting the enormous insect hatches common to the lake in summer. Commercial fishermen landed hundreds of sturgeon and paddlefish in seines. Huge spawning runs of blue suckers attracted settlers to the gorge to pitchfork and club them to feed to livestock and to pickle for later home consumption.
All that changed as industry set its sights on the river as a source of power and transportation. In 1917 a high dam was erected near the foot of the historic rapids that stopped the age-old migration of fish into the rapids. Pollution and lack of access to critical spawning habitat greatly reduced populations of these fish. Since the Clean Water Act of 1972, pollution has been greatly reduced and these fish populations have begun to increase. However the rapids spawning habitat that they need remains a missing link to their full recovery.
Aerial photo of Lock and Dam 1 at the Mississippi River Gorge. | Photo: USACE
Today we have an historic opportunity to return rapids habitat to the Mississippi's last remaining rapids that lies submersed below the reservoir of Lock and Dam 1. Locks have stopped serving the barge industry that they supported for decades and an Army Corps of Engineers Disposition Study is now underway to determine the fate of this dam and another upstream at St. Anthony Falls. Dam removal is a feasible option that could be the recommended outcome of this study. Removal of the dams would allow for restoration of the world-class St. Anthony Falls rapids and reopen the habitat lost a century ago. Sturgeon, Paddlefish, and other rapids dependent species could once again migrate and spawn in the midst of this major metropolitan area and in full view of its human residents.
As we continue to celebrate World Fish Migration Day we look to the new places where we could see rivers once again flowing free. World Fish Migration Day could, in a few years, become an annual celebration along the Mississippi's resurrected rapids in downtown Minneapolis!
TAGS: Floods & Floodplains, Most Endangered Rivers, Restoring Damaged Rivers
One response to "Lake Pepin Fish and the Missing Rapids of the Mississippi River Gorge"
Brian Dawson says:
Just curious as to the effect this will have on invasive species…
Olivia Dorothy
Director, Upper Mississippi River Basin
Learn more about Olivia Dorothy
Explore More From Our Writers
Blue Trails Climate Change & Rivers Conserving Clean Water Dam Removal Discover Rivers Energy Development Environmental Justice Floods & Floodplains Grants Hydropower Most Endangered Rivers National River Cleanup® Protecting Rivers Restoring Damaged Rivers Science Stormwater and Sewage Take Action Urban Waters Water Pollution Water Supply Wild and Scenic Rivers
Join more than 180,000 amazing people who stay up to date on news and ways they can help protect our rivers.
Mississippi River Gorge [MN]
Help us restore a free-flowing Mississippi River through Minneapolis. Tell the Army Corps that...
10 Things You Probably Didn't Know About Migratory Fish
In celebration of the World Fish Migration Day, here are 10 fun facts about migratory fish!...
Migratory Fish and Connected Rivers: Celebrating World Fish Migration Day
Celebrate migratory fish and connected rivers with us!
Removal of Bloede Dam: A Ray of Hope for River Herring
Restoration of Maryland's Patapsco River is re-opening spawning habitat for the first time in...


text:
Man found guilty of murder in November shooting death
Updated: 3:22 PM CDT Jun 11, 2016
A Calhoun County jury has found a Pomeroy man guilty of first-degree murder for the shooting death of a North Dakota man.The Fort Dodge Messenger reports that the jury reached the verdict Friday afternoon in the case against 48-year-old Freddy Crisp, who shot 41-year-old Dale Currie Potter, of Devils Lake, North Dakota.Deputies found Potter dead on Nov. 10 when Crisp called 911 to report the shooting. Crisp was arrested eight days later.Crisp has maintained that he shot Potter in self-defense after Potter pulled a gun during an argument. But prosecutors pointed to inconsistencies in Crisp's recollections about the shooting.Sentencing has been set for July 22, when Crisp faces a mandatory life sentence.
ROCKWELL CITY, Iowa —
A Calhoun County jury has found a Pomeroy man guilty of first-degree murder for the shooting death of a North Dakota man.
The Fort Dodge Messenger reports that the jury reached the verdict Friday afternoon in the case against 48-year-old Freddy Crisp, who shot 41-year-old Dale Currie Potter, of Devils Lake, North Dakota.
Deputies found Potter dead on Nov. 10 when Crisp called 911 to report the shooting. Crisp was arrested eight days later.
Crisp has maintained that he shot Potter in self-defense after Potter pulled a gun during an argument. But prosecutors pointed to inconsistencies in Crisp's recollections about the shooting.
Sentencing has been set for July 22, when Crisp faces a mandatory life sentence.


The family story in wine making goes back to the early 1900s, when great grandfather Mr Kolas established at his home place, Pera Pedi village, one of the very first commercial wineries in Cyprus. Wine making in the old winery was passed down to the next generation but was discontinued in 1978, leaving the place with just memories of a bygone era. It was in 1999, when young Doros Hadjiantonas decided to take on the family tradition and begun practicing wine making as a hobby. At that time, he decided to use the harvested crop from the family vineyards in order to produce small volumes of wine for the family. The experiment proved successful and Doros begun spending hours into piles of wine books, attended a series of wine courses and came into close contact with local winemakers and oenologists. Urged by his enthusiasm and passion and a small initial investment, Doros achieved to produce in 2004 nearly 45.000 bottles of wine, mainly from his family owned vineyards. Keen to see the family name again on wine bottles, he proudly named his wine 'Hadjiantonas' and turned the hobby into a business.


text:
HIPAA: Back to basics with the BAA
Rachel V. Rose, JD, MBA
With cybersecurity and criminal government actions involving protected health information (PHI), now is a good time to understand the importance of the required Business Associate Agreement (BAA).
Before delving into the nuances of the requisite BAA, it's important to highlight the following three items:
Two of the U.S. Department of Justice's (DOJ) False Claims Act enforcement priorities are cybersecurity and electronic health records;
The Eastern District of Texas U.S. Attorney's Office recently announced that another individual out of a group of co-conspirators was sentenced in July 2021 for the "theft of protected health information, the fabrication of physicians' orders, and the sale of prescriptions will not be tolerated in the Eastern District of Texas";
A former Scripps Health employee, as well as three alleged co-conspirators, were charged in San Diego for the theft of patient information, which was in turn used to submit false and fraudulent unemployment claims.
These three items are important because HIPAA, like the Federal Anti-Kickback Statute (AKS), has criminal penalties available to HHS. The DOJ is responsible for criminal prosecutions, as illustrated by the two aforementioned examples. As HHS states on its website,
A person who knowingly obtains or discloses individually identifiable health information in violation of the Privacy Rule may face a criminal penalty of up to $50,000 and up to one-year imprisonment. The criminal penalties increase to $100,000 and up to five years imprisonment if the wrongful conduct involves false pretenses, and to $250,000 and up to 10 years imprisonment if the wrongful conduct involves the intent to sell, transfer, or use identifiable health information for commercial advantage, personal gain or malicious harm.
The inter-play between the FCA, AKS, and HIPAA is illustrated by the DOJ's 2015 enforcement action against pharmaceutical manufacturer Warner Chilcott to resolve a felony healthcare fraud scheme that resulted in a $125 million settlement to resolve criminal and civil liability. Here, the pharmaceutical company remunerated physicians either in cash or in-kind through speaker programs and meals in exchange for access to patient records, which led to reps evaluating and assisting with pre-authorizations or submissions to government programs. In light of the Supreme Court's 2016 Escobar decision, which upheld that false claims can be predicated upon the theory of implied certification, this is an area to watch because it difficult to argue that HIPAA, HITECH Act, and 21st Century Cures Act compliance is not material to the United States Government.
This leads up to the discussion around the BAA. First, a BAA is required between a covered entity and its business associate; and, in turn, between a business associate and its subcontractor. As HHS articulated on its website:
A "business associate" is a person or entity, other than a member of the workforce of a covered entity, who performs functions or activities on behalf of, or provides certain services to, a covered entity that involve access by the business associate to protected health information. A "business associate" also is a subcontractor that creates, receives, maintains, or transmits protected health information on behalf of another business associate. (emphasis added).
Business Associates encompasses a wide range of persons, which include, but are not limited to: accountants, attorneys, private equity firms, technology companies, app developers, independent contractors, medical device companies, and pharmaceutical companies. Bottom line—if you or your company "creates, receives, maintains, or transmits" protected health information in an electronic form, a BAA is required. This is not new—the requirement existed long before the HIPAA Final Omnibus Rule was published in the Federal Register on January 25, 2013.
This leads us to the four primary purposes of the BAA:
provide reasonable assurances that both parties have the requisite technical, administrative, and physical safeguards in place;
that the parties will act in accordance with the HIPAA Privacy and Security Rule, including what entity has the obligation to provide patients with their medical record requests;
breach notification requirements; and
destruction or return of data when the relationship between the parties ends.
Later this month, I will delve into the specifics of the BAA to alleviate any confusion. For those who have read numerous BAAs, it should come as no surprise that certain language is consistent throughout. This is because HHS provided a template. Parties are free to add additional language, but it must not contradict what is required.
The overall take-aways are that HIPAA compliance is not optional and depending on the facts and circumstances, may lead to significant civil and/or criminal liability.
Rachel V. Rose, JD, MBA, advises clients on compliance and transactions in healthcare, cybersecurity, corporate and securities law, while representing plaintiffs in False Claims Act and Dodd-Frank whistleblower cases. She also teaches bioethics at Baylor College of Medicine in Houston. Rachel can be reached through her website, www.rvrose.com.


Specific treatment for very damaged hair due to technical services, especially bleaching, chemical straightening and perms. Consisting of the same mixture of amino acids and noisome as ESLABONDEXX line, Immediate Rescue formula is enriched with vegetable proteins. This special mix of ingredients is absorbed into the hair cortex, strengthening it internally, and at the same time develops a protective film to strengthen, protect and provide shine. It also repairs the hair structure, balances its elasticity, preventing it from breaking after each chemical treatment.
After technical services and in particular bleaching services, chemical straightening and perm.
After Eslabondexx Rescue Shampoo, spray on lengths and tips, especially on the most damaged areas. Leave on for 10 minutes and rinse thoroughly. Complete the treatment by applying Eslabondexx 3.Sustainer. Repeat at least twice a week.
Aqua (Water), Citric Acid, Amodimethicone, Propylene Glycol, Hydrolyzed Vegetable Protein PG-Propyl Silanetriol, Soy Isoflavones, Glycosphingolipids, Acetyl Cysteine, Hydrolyzed Wheat Protein, Polyglyceryl-10 Oleate, Polyglyceryl-6 Laurate, Hydrolyzed Soy Protein, Sorbitan Palmitate, Dicetyl Phosphate, Hydrolyzed Corn Protein, Trideceth-12, PEG-40 Hydrogenated Castor Oil, Arginine, Glycine, Alanine, PCA, Aspartic Acid, Sodium PCA, Sodium Lactate, Polysorbate 20, Serine, Valine, Cetrimonium Chloride, Proline, Threonine, Histidine, Isoleucine, Phenylalanine, Methylchloroisothiazolinone, Phenoxyethanol, Methylisothiazolinone, Parfum (Fragrance), Sodium Benzoate, Benzyl Salicylate.
Nio-protect technology: innovative combination of active ingredients contained into niosomal vesicles. It actively protects hair cells from damages during the chemical service.
Soybean Isoflavones: they provide added nourishment improving hair conditions.
N-acetyl-L-cysteine: it strengthens and protects the hair.
Phytoceramide: derived from rice, it establishes a protective shield around the hair shaft.
Hydrolyzed vegetable protein: unique hydrating complex offering a combination of moisture-balancing and film-forming properties.
Soothing mousse shampoo for sensitive or dry scalp. With softening action, reduces itching sensation and fosters the wellbeing of scalp.
Energizing reinforcing conditioner for fragile hair. Hair is strengthened and easier to comb.
Disciplining spray lotion for curly hair that are likely to become frizzy. With filming and fixing action, shapes curls increasing their definition and hold. Eliminates frizz.


text:
Tag: Uluru Stud
Not A Single Doubt filly wins Angus Armanasco Stakes
There's not much of Summer Sham but she gave her rivals in Saturday's $200,000 MRC Angus Armanasco S. 1400m G2 little chance to weigh in against her as she became Not A Single Doubt's 51st stakeswinner.
The 3YO filly's brilliant gate speed, which gave her an immediate two-length lead, was only part of the race's story. She also showed plenty of heart at the finish and defied Palazzo Vecchio and Miss Wahoo to score by 0.4 lengths in 1:23.37.
Watch Summer Sham win the MRC Angus Armanasco S. G2.
Trainer Danny O'Brien said, "It was a nice race for her today. She drew a good barrier, she was brilliant from the gate and gave nothing else a chance from there.
"She's a sharp filly and it was pleasing to see her get a really strong 1400 metres today in these (windy) conditions."
Now unbeaten in three starts, Summer Sham is likely to be seen next in the VRC A.V. Kewney S. G2 on 10 March, with a Sydney Autumn campaign under consideration.
Bred and raced in partnership by Uluru Stud, Summer Sham is the first foal out of Hot Summer Night (by Fusaichi Pegasus) and boasts 3×3 in-breeding to celebrated broodmare Shantha's Choice. That gives her a pedigree page full of stars including Redoute's Choice, as well as the Group 1-winning filly Shoals, her dam The Broken Shore and Lucky Raquie, all owned by Arrowfield and GSA Bloodstock.
While barnmate Snitzel keeps setting records at the top of the General Sires' Premiership, Not A Single Doubt is steadily compiling another terrific season record. He's 4th by stakeswinners (9) & stakes wins (10), and 5th by earnings with $7.1 million.
Although his lifetime tally of stakeswinners is evenly split between colts (25) and fillies (26), Not A Single Doubt's 2017/18 performance has been dominated by fillies and mares. Caulfield Guineas G1 winner Mighty Boss is the exception, with Summer Sham and Group 3 winners Cool Passion, Faraway Town and Payroll heading the girls' team.
Not A Single Doubt has six colts and two fillies catalogued for next week's Inglis Melbourne Premier Sale, and 19 lots in the Inglis Easter Sale, including a pair of colts in Arrowfield's consignment.
Author UpgrowthPosted on February 26, 2018 Categories Archive NewsTags Arrowfield, Caulfield, Danny O'Brien, Not A Single Doubt, Shantha's Choice, stallions, Summer Sham, Uluru Stud


This pack is for chronic tonsil stone sufferers who also suffer with post nasal drip/sinus problems and has everything required to get rid of the tonsil stones and get the bacterial infestation under control.
Everything you will need to get rid of tonsil stones and to prevent them from coming back is included in this kit. You will start noticing changes in the first day of use already.
Using the tongue cleaner gently scrape your tongue, running the cleaner over the surface of the tongue 5-6 times.
Brush your teeth with Therabreath plus toothpaste and thereafter rinse with Therabreath extra strength oral rinse using one measured capful for 60-90 seconds.
Spray 4-5 squirts of the Therabreath Fresh Breath Throat Spray in your throat and on the back of your tongue 4-5 times during the day. By doing this you will be neutralizing the anaerobic, sulphur producing bacteria.
The lozenges and gum help to stimulate saliva flow and keep breath fresh through out the day, especially when you don't have your toothbrush handy.


Anger management experts focus on teaching you to control your emotions when angry, however, for some people this can take many months or even years to achieve. Many people have difficulty understanding how both physical and emotional well-being need to be balanced in order to have a healthy and happy existence. They are quick to learn avoiding physical pain yet repeat emotional pain time after time.
Having the ability to vent one's anger (catharsis theory) without damaging anything or anyone is often considered a useful anger management coping skill. It might involve taking one's anger out on a punch bag or undertaking some form of physical workout to let off steam, or alternatively, some people find it helpful to go somewhere isolated and simply shout and scream aloud.
However, it should be noted that some studies e.g. Bushman 2002, challenge the belief of venting one's aggression and anger through the release of physical energy e.g. hitting a pillow or punch bag. Some researchers feel that these actions reinforce the expression of hostility and aggression, which may increase the likelihood of a similar and even more intense reaction in the future.
If distancing oneself mentally from the environment proves difficult, physically leaving the environment can be an aid. This is sometimes referred to as 'time-out'.
At a basic level, it is a technique that is commonly taught to children in the form of, 'Count to 10'. However, simple as it is, it can be a very effective technique even for adults; simply keep counting until your anger subsides. If followed through it will prevent instant retaliation, whether physical or verbal. It will help you focus on other things besides your angry emotions and give you time to cool off.
If you are a parent, you know that children can sometimes be extremely challenging. If this is a significant problem for you, what about escaping to recharge your batteries? Consider having a trusted family member or a friend look after them for a few hours (or maybe days), so that you can get away and 'regroup'. Do something that you enjoy – maybe go for a walk, indulge in some retail therapy or do anything that helps you to relax. A more relaxed parent will be a happier person, be less prone to snapping and having angry outbursts at the children, and in general, be a far more pleasant person around others.
Time-outs can refer to many different scenarios. For example, repeated exposure to stressful images, thoughts and situations can intensify your emotional response. If you find that your anger escalates when you are exposed to these triggers, you will need to make a conscious effort to reduce or eliminate exposure to them. For example, some people just tend to wind you up. Avoiding them if at all possible, especially if you or the individual has a pattern of lashing out, takes away the negative emotion that comes with it.
This can be particularly difficult when it involves family members who do not get along but are expected to meet at family gatherings, such as at Thanksgiving or Christmas time. Parents raise children in the expectation that when they become adults with children of their own, large family get-togethers will be joyful occasions to look forward to. Unfortunately, the reality can be somewhat different.
In situations such as these, it is imperative to take control by avoiding excessive alcohol intake, having minimal contact with the individual and when you do, remaining polite. The last thing other family members want to see is a war, especially when children are present. Focus your energy on the other relatives and children present. If you have a desire to resolve the problem it should not be done on such occasions. Instead, get together at a different time and always choose a neutral place to meet e.g. café, coffee shop.
Time-out involves removing oneself from the environment that seems to frustrate and irritate you; it may involve simple things such as going to the next room, having a walk outside or just taking some personal time for yourself each day. Furthermore, taking a vacation and being able to get away helps a person to reflect on one's actions and may give them a different perspective on the problem. If it is not possible to travel alone, make a conscious decision to at least spend some time alone on holiday. Space and time can be very therapeutic.
Sometimes the process of being grateful and not taking what we have for granted can help extinguish the anger that resides in us. Making a habit of being appreciative, paying compliments and showing love and affection to those around us, becomes a way of life that's not only good karma but a sign that the person is at peace with themselves. 'Practice makes perfect' applies in this context and through it, we and everyone around us become happier.
Make time to listen to the voice in your head – it's not a sign of madness! We all talk to ourselves in our head and though we may not be aware of it, we typically have a running commentary of self-talk most of the time. Catch what's being said and work on developing rational self-talk, especially as your anger rises. Also, injecting humorous thoughts can be a way of diffusing anger.
These will vary from person to person, but some people find it a useful tool for letting things go and not choosing anger when confronted by unreasonable people or actions. Violent or aggressive imagery should always be avoided.
For example, consider people as apples in a bucket. Out of ten apples, 5 will be lovely and healthy, 3 are average in appearance and 2 are rotten to the core. Instead of feeling angry at the rotten apples, feel sorry for them. In this context it means not responding with anger or aggression to unpleasant situations and unreasonable people. Accept that is what they are but you choose not to become tainted.
Don't take it upon yourself to be judge and jury in every negative situation. Some people deal with it by believing in Karma and 'what goes around comes around', whilst some religious people find additional comfort in the belief that retribution for unreasonable acts will come on judgment day!
In addition, many people find visualizing a potentially confrontational scenario very helpful. Role-play in your mind, rehearse a response and focus on staying in control. Speak calmly and maintain a slower pace of speech. Then, when the time arises in real life, put into practice what you have visualized.


The complete genetic blueprint for 2 of the deadliest cancers, pancreatic cancer and brain cancer, was recently deciphered by a team at the Johns Hopkins Kimmel Cancer Center. Understanding the molecular mechanisms of these cancers can help us develop new therapeutic modalities. You are listening to ReachMD, The Channel for Medical Professionals. Welcome to The Clinicians Roundtable, I am Dr. Leslie Lundt and with me today is one of the investigators in this trial, Dr. Will Parsons. Dr. Parsons is a Fellow in Pediatric Oncology at the Johns Hopkins Kimmel Cancer Center. Dr. Parsons' long-term goal is to develop as an independent translational investigator in the molecular biology and treatment of brain tumors. He currently is undertaking a large scale genomic approach in collaboration with the Kinzler-Vogelstein labsto sequence more than 15,000 genes from several cases of both glioblastoma multiforme and medulloblastoma.
Welcome to ReachMD Dr. Parsons.
I appreciate you having me.
Why study pancreatic and brain cancer Will?
There are 2 reasons we did that, one was that they are both among relatively common cancers in the United States with pancreatic cancer occurring in roughly 40,000 new patients a year and brain cancer glioblastoma in about half of that and they also are ones that we have very limited treatment options.
So, tell us what you have found so far.
I am just going to go back a little bit if I may to explain the origin of why we are doing this study. Over the last 20 years or so, it has become clear that cancer is an essence of genetic disease. I am not meaning that it is something that's inherited from your parents, but it is a disease in which mutations in individual genes in a cell cause the cells to grow out of control and not die when they are supposed to and generally not be regulated in any way, and in the few cases, investigators have found specific genes causing that process and have been able to target them for therapies and for medicines and also in terms of diagnostics and has been remarkably successful in a few isolated instances. What's become clear though is that we really don't know the real framework and the vast majority of the genes and the genetic alterations that are causing these cancers. So, our goal here was to take a step back, start from the beginning and look at all the genes that are present in the human tumor cells and try and figure out what's going on.
What we found was that the background and the landscape so to speak is much more complicated than we might have imagined. So, instead of having only 1 or 2 alterations in a single gene or it being in a very limited number of genes, we found the average tumor cell in pancreatic and brain cancer to have on the order of 60 different mutations or alterations occurring.
In 1 cell and part of the trick has been figuring out which of those are occurring just due to chance because in the replication of DNA in the cell there is always some background rate of errors that are occurring and some of them likely have nothing to do with the growth of the cell and try and differentiate those from ones that are really making a difference, and so, we have to derive all sorts of statistical kinds of tests for that and ways to look at it. In the end, all it comes down to is on the order of about 10 of them, 10 to 15 may be are actually playing a role in creating the cancer.
Now in your paper, you mentioned pathways, tell us about that.
Well one way to make this more simplified both in terms of making sense of it intellectually and also in terms of targeting these changes in terms of using them for diagnostics or therapeutics is to provide some order to it and in one way we can do that is by assigning these genes to different pathways, so for example, there might be a pathway that's involved in certain aspect of cell growth and there are number of different genes in that pathway, what we have found is that different tumors may have different mutations within different genes in that pathway. So, instead of all of them simply having something wrong with gene A, some proportion of them may have something wrong with gene A, some other proportion different tumor has something with gene B, and so on, so that the net effect is that the pathway is affected in nearly all the tumors, but that in any single individual tumor, there is some variety to it.
What do we know Will about the difference between solid tumors and other problems like leukemia.
We are still learning about that a little bit. Most of the studies that we have done so far have focussed on solid tumors and so the numbers in terms of numbers of mutations and things that I was talking about are most directly relevant to that. Other investigators have also been looking at leukemia or what we call from the more liquid tumors. There have been a couple of very interesting cases and leukemia is where a single alteration, in one case, a translocation between 2 different genes occurring in chronic myelogenous leukemia for example has been found in the vast majority of patients which is obviously a very nice finding because then it can be targeted with a single medicine or single group of medicines in most patients, so that's really been quite effective. We are still learning about some of the differences between the tumor types.
If you are just joining us, you are listening to The Clinicians Roundtable on ReachMD, The Channel for Medical Professionals. I am Dr. Leslie Lundt, your host, and with me today is Dr. Will Parsons. We are discussing his research looking into the molecular mechanisms of cancer.
Will, it has been suggested that may be the development of new treatments is really not the way of the future for looking at cancer, should we may be focussing our energy on prevention and early detection instead of treatment necessarily?
I think that's a great point and that's actually one of the things we are very interested in looking at. The important part to note about these studies we are doing is that we are just trying to find the background information such that we can design rationale purchase to all of these questions. So for example, by finding the different mutations that are commonly occurring in tumors, we can use it in number of ways.
1. You can obviously design medicines for those changes which is what you are first referring to.
2. You can use the changes for diagnosis and prognostication, for example, one of the mutations that we found in a decent minority of patients with glioblastomas was found to be associated with a much more benign relatively speaking clinical course. So instead of having a medium survival for about a year as most patients with that terrible tumor do, those patients had a survival of more like 4 years and might be susceptible to different treatment. Then the third leg of that is what you are getting at is something I think is really interesting in that once we have knowledge of these changes, our hope is that we will be able to use them for early diagnosis as well. For example, it is now possible to detect DNA and mutated DNA from tumors in blood even if it's not a leukemia or not a tumor that's normally in the blood. So, we could for example if we have common mutations or panel of mutations that are occurring in one of these tumors, to design a test from the blood to see if you see any these alterations and obviously that would be a way of hopefully diagnosing them earlier. So, both of these types of tumors, they are ones that create symptoms relatively late and at that point it is already a big problem.
Then of course we have to think about ethical issues like insurance coverability, that's the word, if you have that certain panel of mutations that are likely to develop cancer, might you have a hard time getting insurance.
I guess that's going to be one of the big ethical issues facing us in the century is how to handle this additional information about the patient. You know obviously, the basic principles are the same in terms of not sharing them in ways that the patients are not approving off and we have all the regulations that you know well about governing that, that clearly in these next years is going to be of infinite amount more genetic information available, so it is going to require us to be very careful about how we use them.
So, what's next with your work?
What's next is couple of different things. One is we are very interested in looking at other different tumor types and comparing them because some of the most valuable information we find is when we find things that are either common to multiple types of tumors, so for example, a gene might be mutated in brain cancers and also pancreatic cancers, but then it is also interesting to see what the differences are and for example as you are asking about the leukemias before what kind of differences in terms of number of mutations in terms of the types of genes that are mutated and what that might say about these things mechanistically. Looking at other kinds of tumors is one step. The other important part is followup on the findings that we have from these sources of studies, so these are only first step in terms of providing any improved therapies for patients for these kinds of cancers. First we find these genes, next we have to look at them and see, for example, what they are doing, how these mutations alter their function, try to figure out such ways in which we could target that in some ways in which we can use them for diagnostic. So, really the next step is following up on some of the interesting genes.
Now, I assume that a lot of this work is done at multiple centers not just at Hopkins. How do you coordinate what must be a massive amount of information?
It's absolutely true. It's a collaborative effort. Many of these "big science projects" that are being done these days by necessity require a bunch of different people, resources from different places, and talents from different groups. So, this project, for example, was done primarily here at Hopkins, but also with our collaborators at Duke University and a number of others. In part, that's because the samples are difficult to come by because it requires really carefully curated and analyzed samples such that we know that they are very pure tumor samples that does match normal DNA, for example, from the same patients and that we have associated clinical data, so we can make some sense of the results. So, it is something that requires a number of groups. Basically, the way we do it is frequent communication, a number of meetings, and having a very clear overall plan of which parts of the group are responsible for which parts of the project and then we adapt from there, a very effective way to do things, to rely on the talents of a number of different people.
And in this most recent study how many patients roughly did you look at?
Roughly we looked at on the order of 100 patients with each of the different types of tumors.
So, you had mentioned that one of the next steps is to look at other tumors, what else besides glioblastoma and pancreatic CA are you interested in?
We are interested in number of others actually and we are still trying to decide where to go next. In other studies we have already looked at breast and colon cancer on a slightly smaller scale than on this project. So, we are interested on those results as well.
Now if people want to learn more about your work, where should they look?
The simplest way to do it would be to in terms of looking on the Internet would be just to search for Johns Hopkins Sidney Kimmel Comprehensive Cancer Center and then search for any of these types of tumors that I am talking about.
Fantastic. Will thank you so much for your time today.
No problem. It is good talking to you.
We have been speaking with Dr. Will Parsons from the Johns Hopkins Sidney Kimmel Cancer Center in Baltimore, Maryland. An interesting question perhaps the development of new therapeutics is not the way of the future for cancer treatment could provide for a thought. I am Dr. Leslie Lundt. You are listening to ReachMD, The Channel for Medical Professionals. For a complete program guide and downloadable pod casts, visit our website at www.reachmd.com. Thank you for listening.
You are listening to ReachMD, The Channel for Medical Professionals. Here is a sample of the great shows airing this week. I am Lisa Deandre. Join me this week on The Clinicians Roundtable, when I will be speaking with Sue Kling Colson about the University of Michigan's Hospital Intensive Insulin Program.
This is Dr. Mark Nolan Hill. This week we will be speaking with Dr. John Dixon, Associate Professor of Medicine at Monash University Medical School in Melbourne, Australia. We will be talking about gastric banding surgery towards type 2 diabetes remission.
This is Susan Dolan, join me this week when my guest will be Amparo Gonzales, President of the American Association of Diabetes Educators discussing how diabetes educators are making a difference for patients and physicians.
Thank you for listening to ReachMD where we change topics every 15 minutes. For our complete weekly guest and program guides, visit us at www.reachmd.com.
The complete genetic blueprint for two of the deadliest cancers, pancreatic and brain cancer, was recently deciphered by a team at the Johns Hopkins Kimmel Cancer Center. Understanding the molecular mechanisms of these cancers can help us develop new therapeutic modalities. In this segment, Dr. Will Parsons, one of the trial investigators, joins host Dr. Leslie Lundt to discuss the groundbreaking results of their work.


text:
Q: Expectation of an Observable If we have the complex scalar
$\langle f|\Omega|g\rangle$ as in equation (2.73) of these course notes (where $\Omega$ is Hermitian), and want to evaluate it in the position basis, I would proceed as follows:
$\langle f|\Omega|g\rangle  =\iint dx \ dy\langle f|y\rangle  \langle y|\Omega|x\rangle  \langle x|g\rangle  =\iint dx \ dy \ (f(y))^{*}g(x)\langle y|\Omega|x\rangle \quad \quad \mathbf{(1)} $
However, said notes claim that
$\langle f|\Omega|g\rangle=\int dx \ (\Omega f(x))^{*}\ g(x)=\int dx \ (f(x))^{*}\Omega \ g(x) \quad \quad \mathbf{(2)}$
which I don't understand. I'm okay with the first equality in $\mathbf{(2)}$, but have an issue with the second one. $(\Omega f(x))^{*}$ is really $\langle \Omega f | x\rangle=(\langle x|\Omega|f\rangle)^{\dagger}$, so I don't see how the $\Omega$ can just be plucked out.
Context:
I want to evaluate the expectation $\langle \hat{O}\rangle_{\psi}$ of observable $\hat{O}$ using the position basis. By my usual approach in $\mathbf{(1)}$,
$\langle \psi| \hat{O} | \psi \rangle=\iint dx\ dy \ (\psi(y))^{*}\psi(x)\langle y|\hat{O}|x\rangle$
but if this can be whittled down to
$\langle \psi| \hat{O} | \psi \rangle=\int dx \ \|\psi(x)\|^{2}\langle x|\hat{O}|x\rangle$
then I'd like to know if that is indeed possible! I was trying to follow part 2 of Valerio's answer here.

A: First, let's be familiar with the notation given on your source.
Consider a Hermitian operator $\Omega$ so that
$$\Omega=\Omega^\dagger$$
Look at the matrix element of $\Omega$ in some basis
$$\langle u|\Omega|v\rangle=\langle u|\Omega v\rangle$$
or $$\langle u|\Omega|v\rangle=\langle u|\Omega^{\dagger}|v\rangle=\langle \Omega u| v\rangle=\langle u|\Omega v\rangle$$

Note the following
$$\Omega|v\rangle=|\Omega v\rangle$$ and
$$\langle u|\Omega^\dagger=\langle \Omega u|$$

Now for functions $f(x)$ and $g(x)\in \mathcal{C}$
$$\langle f|g\rangle=\int(f(x))^*g(x)dx$$
where * means complex conjugate. Also for Hermitian operator, we have proved above:
$$\langle \Omega f| g\rangle=\langle f|\Omega g\rangle$$
The quantity of interest
$$\langle f|\Omega|g \rangle=\langle \Omega f| g\rangle=\langle f|\Omega g\rangle$$
In position basis we can directly write
$$\langle \Omega f| g\rangle=\int(\Omega f(x))^*g(x)dx$$
and $$\langle f|\Omega g\rangle=\int(f(x))^*(\Omega g(x))dx$$
$$\int(\Omega f(x))^*g(x)dx=\int(f(x))^*(\Omega g(x))dx$$
Note that $\Omega $ is still a abstract operator because we don't know its matrix element $\langle x|\Omega|x'\rangle$ in position basis. But this doesn't change the equality of those two.

You can do them another way:
$$\langle f|\Omega| g\rangle=\int \langle f|x\rangle\langle x|\Omega|g\rangle dx=\int (f(x))^* (\Omega g(x))dx$$
or $$\langle f|\Omega| g\rangle=\int \langle f|\Omega|x\rangle\langle x|g\rangle dx=\int (\Omega f(x))^* g(x) dx $$
which are equal.


Have you heard of the iphone contract that Janell Burley Hofmann set up for her son? Its made national news and after reading it.. I just had to share it. You can also find this, along with many other great posts on her blog at Janell Burley Hofmann.com.
Have a read for yourself..
12. Do not send or receive pictures of your private parts or anyone else's private parts. Don't laugh. Someday you will be tempted to do this despite your high intelligence. It is risky and could ruin your teenage/college/adult life. It is always a bad idea. Cyberspace is vast and more powerful than you. And it is hard to make anything of this magnitude disappear — including a bad reputation.
So what do you think? I think its brilliant. Its something that we all should be doing for our kids. With all the technology avilable now.. we all have to set up guidelines for our young kids who are just starting to experience all the vast amounts of technology that surrounds them. Just a few weeks ago, I took my 11 year olds smart phone.. uploaded everything.. including contacts.. and I was able to get all the text messages and emails too. I don't think in this era we can be too safe with our kids.
Just had to share this.. any thoughts?
11 comments on "Take Note Parents.. ↓This is how its Done ↓"
I read about this last week, and it's awesome! COMPLETELY AWESOME!!!
I do not even have children and I think this is awesome.
I have 15 nieces and nephews though and I hope that their parents have a contract like this between them before a phone is given.
I agree with you, it is brilliant! Love it! Thanks for becoming a Follower of my Blog. I am happy to follow back.
@ 2justByou.. Its amazing right!? I loved it!
@ Suburban Prep.. I think its great. Both of my kids have smart phones at 10 and 11 years old.. I didn't make them sign anything but we had some serious discussions about the right and wrong ways to use their devices. So far so good..and we have spot checks where I take the phones when I want and go through them.. so far so good!
OK love this! We have 6 kids, 5 boys and a baby girl! Our rule on cell phones is you get one when you turn 16, so J will be 16 in September, he already told my hubbie which one he wants! I had some rules wrote down also, but I sure enough will be using some of her rules. I totally agree with everything in this!
Thanks for visiting my blog and following, I am a follower also!
@ Judy.. Nice to meet you! I love the contract.. Love.. love .. love!! Happy New Year!
@ Ceri G.. Nice to meet you! Happy to be following you.. can't wait to get to know you better in the future!
@ Pamela.. You should take some take some or all of those rules.. My kids take the phone to school but it has to be on silent. I like the idea of GPS being on the phones in case something God Awful was to happen.. ( watch Nancy Grace wayyy to much! ) but besides that.. I totally agree with everything! Good luck with your son in September!! I bet he will do great with it!
Fun blog! Thanks so much for following Saved by Grace -- I'm following you back!
I saw this on Pinterest and loved it! This lady is awesome!
This is awesome! I had not heard about this before. My kids are still far too young for a cell phone of any kind (3 and 1), but I will definitely keep this in mind for when they're older. Thanks for sharing!
@ Michelle.. Nice to meet you too! =) And yes.. shes right on the money with how to give a child a phone.. Loved it!
@ Ms T.. Print it off and put it in your files because I guessing sometime in the future.. you might need it!


text:
Home The Sunday Standard
Pakistan launches sneaky cyber attack on Indian Army
The neighbour is striking Indian Army personnel by sending virus-laden emails
Published: 16th October 2016 08:48 AM | Last Updated: 16th October 2016 10:29 AM | A+A A-
Few Army translators for terror chatter
By Pradip R Sagar
NEW DELHI: India's cross-border surgical strikes involved real men and real bullets. In a counter- offensive, Pakistan is using computers and virus-laden emails to 'attack' the Indian Army. Launching a cyber war, Pakistan Army is sending spoofed emails to Indian Army personnel with the subject line 'Actual story of surgical strike done by Indian Army in PoK'. A hacked email address of a key office in the directorate of military intelligence is being used to send and give credibility of the phishing mail.
With a large number of Army personnel reporting the cyber attack in the last 10 days, Army Headquarters has issued an alert to all its units to be cautious.
"The content of the email tempts users to trust the legitimacy of the message by indicating that the attached document is an official statement from Indian Army on surgical strike in PoK and subsequent response after Uri attack," a Army Headquarters statement said.
After tracing the spoofed email, the Army's Cyber Group established that the malicious file's IP address was linked to a server in Germany, which appears to be fake.
"This malware is designed to steal user data and credentials. It also allows the hackers to take remote control of the targeted machine (computer)," an Army Cyber Group alert confirmed.
Since the September 29 pre-dawn strike by Indian commandos of the Special Forces, Pakistan has carried out several attacks in the virtual world. At least 50 IT companies in Hyderabad have come under a wave of cyber attacks from Pakistan-based hackers over the past 10 days.
On October 3, the National Green Tribunal's website was attacked by a group of Pakistani hackers who posted a message mocking the Indian side over the surgical strikes.
Few months ago, China's Western Headquarters, which overseas India, launched a cyber attack on the Indian Army, raising alarms bells.
Recently, a similar cyber attack was launched in the name of the Seventh Central Pay Commission malware, a topic of interest among defence and government officials. In 2013, computer systems of the Defence Research and Development Organisation were breached by Chinese hackers.


text:
Eastern District of Virginia
Meet the United States Attorney
EDVA Overview
Find a Court Document
Locate an Inmate
Environmental Justice and Enforcement
U.S. Attorneys » Eastern District of Virginia » News
Recidivist Defendant Sentenced to 120 Months for Possession of Child Pornography
ALEXANDRIA, Va. – An Alexandria man was sentenced yesterday to 10 years in prison followed by a lifetime of supervised release for possession of child pornography.
James B. Clawson Sr., 59, was convicted by a federal jury in the Eastern District of Virginia of possession of child pornography on Aug. 26, 2021. According to court documents and evidence presented at trial, Clawson was previously convicted of distribution of child pornography in the Eastern District of Virginia after law enforcement discovered that he was serving as the administrator of an online forum dedicated to child sexual abuse material and distributing such material to members of his forum.
While on a term of federal supervised release in connection with this conviction, a U.S. Probation Officer visited Clawson's home and found a laptop and thumb drives in a hidden compartment in Clawson's closet. Though Clawson had denied owning a laptop, law enforcement's investigation established that Clawson had been using the laptop to search for and download images and videos of minors engaged in sexually explicit conduct, which he then stored on one of his thumb drives. Once saved to his thumb drive, Clawson categorized and renamed these files based on the specific sexual conduct they depicted.
Jessica D. Aber, U.S. Attorney for the Eastern District of Virginia and Assistant Attorney General Kenneth A. Polite Jr. of the Justice Department's Criminal Division, made the announcement.
The FBI Washington Field Office investigated the case, with significant assistance from the High Technology Investigative Unit of the Justice Department Criminal Division's Child Exploitation and Obscenity Section (CEOS).
Assistant U.S. Attorney Seth M. Schlessinger and Trial Attorney William G. Clayman of the Criminal Division's CEOS prosecuted the case.
This case was brought as part of Project Safe Childhood, a nationwide initiative to combat the epidemic of child sexual exploitation and abuse, launched in May 2006 by the Department of Justice. Led by U.S. Attorneys' Offices and CEOS, Project Safe Childhood marshals federal, state, and local resources to better locate, apprehend, and prosecute individuals who exploit children via the internet, as well as to identify and rescue victims. For more information about Project Safe Childhood, please visit http://www.justice.gov/psc.
A copy of this press release is located on the website of the U.S. Attorney's Office for the Eastern District of Virginia. Related court documents and information are located on the website of the District Court for the Eastern District of Virginia or on PACER by searching for Case No. 1:20-cr-119.
Criminal - Child Exploitation and Obscenity Section
USAO - Virginia, Eastern
USAVAE.Press@usdoj.gov
NICS Inquiries
NICS Inquiries/Firearms Records Checks
Send to USAVAE.NICS@usdoj.gov
Protect yourself from fraud, and report suspected cases of financial fraud to local law enforcement.
Victim Witness Case
U.S. V. KRISTOPHER LEE DALLMANN ET AL
U.S. V. JAVAID PERWAIZ
U.S. V. ALEKSEI BURKOV
U.S. V. CHOKSI
Megaupload - Release For Victim Notification
Project Safe Neighborhoods (PSN)
Talk to your kids about gangs and how to avoid them.