text:
It doesn't get much beta than this: Novel beta-lactam antibiotics for multidrug-resistant gram-negative organisms
By Adrienne Terico, PharmD, BCPS, BCIDP*
As the threat of infection with multidrug-resistant gram-negative organisms persists, new antimicrobials are a welcome addition to the armamentarium of infectious diseases clinicians.
The intrinsic and acquired resistance mechanisms of gram-negative bacteria, coupled with their ability to share resistance genes with one another, provide these organisms with great survival advantages. As demonstrated over the past few decades, infections with multidrug-resistant gram-negative organisms (MDR GNOs) are responsible for great morbidity and mortality.1 As these pathogens continue to threaten the health of many, much focus has been on the development of new antimicrobials targeted against these organisms and their expressed resistance mechanisms. Imipenem-cilastatin-relebactam (IMI-REL) and cefiderocol are 2 intravenous novel beta- (β-)lactam–based therapies with broad-spectrum activity that target some of the most common modalities of resistance employed by MDR GNOs.
IMI-REL
Relebactam is a non–β-lactam, bicyclic diazabicyclooctane β-lactamase inhibitor, with a structure similar to that of avibactam. When paired with imipenem, it provides additional activity against organisms that produce Ambler class A (eg, extended spectrum β-lactamases and Klebsiella pneumoniae carbapenemases) and class C (eg, AmpC) β-lactamases.2 This leads to enhanced activity against many species of Enterobacterales as well as Pseudomonas aeruginosa.
The addition of relebactam to imipenem improves its activity against non-Proteeae Enterobacterales significantly, with 78.5% to 95% of imipenem-nonsusceptible organisms demonstrating in vitrosusceptibility to IMI-REL.3,4 This improved activity is primarily due to inhibition of β-lactamases, especially Klebsiella pneumoniae carbapenemases. Against non-Proteeae Enterobacterales, IMI-REL has activity similar to that of ceftazidime-avibactam and meropenem-vaborbactam. Imipenem is intrinsically less active against Proteus mirabilis due to decreased binding of penicillin-binding proteins; therefore, the addition of relebactam has a negligible effect on its activity against this species.3,5
The major mechanism of P aeruginosa resistance against imipenem is a combination of downregulation of an outer membrane protein paired with AmpC production.1 Relebactam inhibition of AmpC resulted in improved in vitrosusceptibility against approximately 78% of imipenem-nonsusceptible P aeruginosa isolates.3,6 Improved antipseudomonal activity is an advantage of IMI-REL when compared with meropenem-vaborbactam. This is due to differing mechanisms of resistance to the carbapenem backbone. Resistance to meropenem in P aeruginosa is the result of multidrug efflux pumps, namely the MexA-MexB-OprM system; therefore, the addition of the β-lactamase inhibitor vaborbactam does not improve the antipseudomonal activity of meropenem in the slightest.2 Other novel β-lactam/β-lactamase inhibitors with improved activity against carbapenem-resistant P aeruginosa include ceftolozane-tazobactam and ceftazidime-avibactam. Similar to IMI-REL, this is primarily due to inhibition of AmpC; ceftolozane-tazobactam is also less susceptible to efflux pumps.7,8IMI-REL and the aforementioned agents do not have improved activity against other pathogenic nonfermenting GNOs, such as Acinetobacter baumanii or Stenotrophomonas maltophilia, as they frequently produce class B and D β-lactamases.2
IMI-REL received approval from the FDA for intraabdominal infections and complicated urinary tract infections (cUTI) on the basis of two phase 2 trials, which established the noninferiority of IMI-REL to imipenem alone. Most organisms in these studies were carbapenem-susceptible.9,10 RESTORE-IMI 1 sought to study IMI-REL in a more applicable setting: the treatment of carbapenem-nonsusceptible infections. This study demonstrated an overall favorable response to IMI-REL that was comparable with imipenem plus colistin, with lower numerical 28-day mortality and less nephrotoxicity in patients who received IMI-REL. While this small study (n = 31) was not powered for statistical inference, it provided a basis for the utilization of IMI-REL to treat carbapenem-nonsusceptible GNOs.11 Results from RESTORE-IMI 2 led to an additional FDA indication for the treatment of hospital-acquired and ventilator-associated pneumonia. In this double-blind, phase 3, noninferiority trial, IMI-REL was noninferior to piperacillin-tazobactam with regard to 28-day mortality and response at end of follow-up.12 These studies provided an array of evidence to use IMI-REL confidently in clinical practice. A summary of the aforementioned studies is available in Table 1.
Cefiderocol
Cefiderocol is a siderophore cephalosporin that utilizes a "Trojan horse" strategy to overcome resistance associated with passive diffusion across the cell membrane of GNOs. Although similar in structure to ceftazidime and cefepime, the addition of a catechol moiety on the side chain at position 3 permits cefiderocol to chelate iron, allowing for active transport across the cell membrane via iron transporter channels.13 In addition to avoiding resistance mechanisms associated with passive diffusion, cefiderocol is stable against hydrolysis by β-lactamases in all 4 Ambler classes, including metallo-β-lactamases, and it is minimally affected by multidrug efflux pumps.13,14
As one might imagine, bypassing 3 major mechanisms of resistance leads to significantly improved in vitroactivity against many GNOs, fermenters and nonfermenters alike. A series of surveillance studies under the SIDERO-WT program evaluated 28,629 GNO clinical isolates from North America and Europe over a period of 3 years and demonstrated that more than 99% of isolates had low cefiderocol minimum inhibitory concentration (MIC) values.14-20 The multinational SIDERO-CR 2014/2016 program specifically collected carbapenem-resistant isolates, for which cefiderocol suppressed the growth of 96.2% at the MIC breakpoint of ≤4.14,21-23 Against carbapenem-resistant Enterobacterales (n = 1022), including 23% ceftazidime-avibactam–resistant isolates, cefiderocol suppressed the growth of 97% of strains. For MDR A baumannii (n = 368), P aeruginosa (n = 262), and S maltophilia (n = 217), cefiderocol suppressed the growth of 90.9%, 99.2%, and 100%, respectively. This included 71.4% ceftolozane-tazobactam–resistant P aeruginosa.21,22 Its gram-positive and anaerobic activity is essentially negligible, which is a disadvantage when compared with the more recently available β-lactam/β-lactamase inhibitors described above.13
While it's in vitroactivity is captivating to infectious diseases clinicians everywhere, the indication for which cefiderocol received initial FDA approval was lackluster at best. Its approval for cUTI in adults with limited or no treatment options was based on a phase 2 study that established noninferiority of cefiderocol compared with imipenem/cilastatin.24 The CREDIBLE-CR study evaluated the use of cefiderocol compared with best available therapy (BAT) for infections caused by carbapenem-resistant organisms and was included as part of the application for approval prior to its peer review and publication.25 Although it was not powered to assess for differences in mortality, an obvious imbalance was seen in patients receiving cefiderocol for pneumonia, bloodstream infections (BSI), or sepsis—a majority of which were caused by A baumannii in critically ill patients. The concern surrounding this result is reflected as a warning for increase in all-cause mortality in the prescribing information.26 Subsequently, results were made available prepublication for the APEKS-NP study, which evaluated patients with nosocomial pneumonia caused by carbapenem-susceptible organisms. Cefiderocol met noninferiority compared with high-dose extended-infusion meropenem for the primary outcome of all-cause mortality at day 14, with similar results at day 28.25,27 While the APEKS-NP study did not show any mortality concerns, it also did not reflect real-world use of this agent for carbapenem-resistant organisms. The GAMECHANGER study is currently enrolling patients to receive cefiderocol or BAT for gram-negative BSIs and will hopefully provide some insight on its utility for treatment of severe infections caused by MDR GNOs.28
In conclusion, IMI-REL and cefiderocol are broad-spectrum agents that fill a void in the armamentarium against MDR GNOs. Although broad-spectrum, each has its own niche in vitroto combat specific resistance mechanisms expressed by these organisms, for which their use should ultimately be reserved. While clinical data have been made available demonstrating success of IMI-REL against BAT for MDR GNOS, such data for cefiderocol are incomplete and arguably conflicting at this time.9-12,25,27 However, it must not go unnoticed that in the grand scheme of gram-negative infections, those caused by extensively MDR organisms are few and far between and extremely difficult to study with sufficient power analyses in clinical practice. Hopefully, full publication of CREDIBLE-CR, APEKS-NP, and the GAMECHANGER studies will help define the clinical utility of cefiderocol. In the meantime, this agent will likely be reserved for the treatment of infections where other options are limited to none, as highlighted in a number of case reports of successful treatment thus far.29-32
Adrienne Terico, PharmD, BCPS, BCIDP, is currently the clinical pharmacy specialist in infectious diseases at Pennsylvania Hospital in Philadelphia. Her interests include multidrug-resistant organisms and antimicrobial stewardship.
Antibiotic resistance threats in the United States: 2019. CDC. November 2019. Updated December 2019. Accessed July 23, 2020. https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf
Zhanel GG, Lawrence CK, Adam H, et al. Imipenem-relebactam and meropenem-vaborbactam: two novel carbapenem-β-lactamase inhibitor combinations. Drugs. 2018;78(1):65-98. doi:10.1007/s40265-017-0851-9
Karlowsky JA, Lob SH, Kazmierczak KM, et al. In vitro activity of imipenem-relebactam against clinical isolates of gram-negative bacilli isolated in hospital laboratories in the United States as part of the SMART 2016 program. Antmicrob Agents Chemother. 2018;62(7):e00169-18. doi:10.1128/AAC.00169-18
Canver MC, Satlin MJ, Westblade LF, et al. Activity of imipenem-relebactam and comparator agents against genetically characterized isolates of carbapenem-resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2019;63(9):e00672-19. doi:10.1128/AAC.00672-19
Bontron S, Poirel L, Kieffer N, et al. Increased resistance to carbapenems in Proteus mirabilis mediated by amplification of the blavim-1-carrying and IS 26-associated class 1 integron. Microb Drug Resist. 2019;25(5):663-667. doi:10.1089/mdr.2018.0365
Lob S, Hackel MA, Kazmierczak KM, et al. In vitro activity of imipenem-relebactam against gram-negative ESKAPE pathogens isolated by clinical laboratories in the United States in 2015 (results from the SMART Global Surveillance Program). Antimicrob Agents Chemother. 2017;61(6):e02209-16. doi:10.1128/AAC.02209-16
Legacé-Wiens P, Walkty A, Karlowsky JA. Ceftazidime-avibactam: an evidence-based review of its pharmacology and potential use in the treatment of Gram-negative bacterial infections. Core Evid. 2014;9:13-15. doi:10.2147/CE.S40698
Cabot G, Bruchmann S, Mulet X, et al. Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC. Antimicrob Agents Chemother. 2014;58(6):3091-3099. doi:10.1128/AAC.02462-13
Lucasti C, Vasile L, Sandesc D, et al. Phase 2, dose-ranging study of relebactam with imipenem-cilastatin in subjects with complicated intra-abdominal infection. Antimicrob Agents Chemother. 2016;60(10):6234-6243. doi:10.1128/AAC.00633-16
Sims M, Mariyanovski V, McLeroth P, et al. Prospective, randomized, double-blind, phase 2 dose-ranging study comparing efficacy and safety of imipenem/cilastatin plus relebactam with imipenem/cilastatin alone in patients with complicated urinary tract infection. J Antimicrob Chemother. 2017;172;(9):2616-2626. doi:10.1093/jac/dkx139
Motsch J, Murta de Oliveira C, Stus V, et al. RESTORE-IMI 1: a multicenter, randomized, double-blind trial comparing efficacy and safety of imipenem/relebactam vs colistin plus imipenem in patients with imipenem-nonsusceptible bacterial infections. Clin Infect Dis. 2020;70(9):1799-1808. doi:10.1093/cid/ciz530
Titov I, Wunderink RG, Roquilly A, et al. A randomized, double-blind, multicenter trial comparing efficacy and safety of imipenem/cilastatin/relebactam versus piperacillin/tazobactam in adults with hospital-acquired or ventilator-associated bacterial pneumonia (RESTORE-IMI 2 study). Clin Infect Dis. Published online August 12, 2020. doi:10.1093/cid/ciaa803
Zhanel GG, Golden AR, Zelenitsky S, et al. Cefiderocol: a siderophore cephalosporin with activity against carbapenem-resistant and multidrug-resistant Gram-negative bacilli. Drugs. 2019;79(3):271-289. doi:10.1007/s40265-019-1055-2
Sato T, Yamawaki K. Cefiderocol: discovery, chemistry, and in vivo profiles of a novel siderophore cephalosporin. Clin Infect Dis. 2019;69(S7):S538-S543. doi:10.1093/cid/ciz826
Hackel MA, Tsuji M, Yamano Y, et al. In vitro activity of the siderophore cephalosporin, cefiderocol, against a recent collection of clinically relevant Gram-negative bacilli from North America and Europe, including carbapenem-nonsusceptible isolates (SIDERO-WT-2014 study). Antmicrob Agents Chemother. 2017;61(9):e00093-17. doi:10.1128/AAC.00093-17
Karlowsky JA, Hackel MA, Tsuji M, et al. In vitroactivity of cefiderocol, a siderophore cephalosporin, against Gram-negative bacilli isolated by clinical laboratories in North America and Europe in 2015-2016: SIDERO-WT-2015. Int J Antimicrob Agents. 2019;53(4):456-466. doi:10.1016/j.ijantimicag.2018.11.007
Kazmierczak KM, Tsuji M, Wise MG, et al. In vitroactivity of cefiderocol, a siderophore cephalosporin, against a recent collection of clinically relevant carbapenem–non-susceptible Gram-negative bacilli, including serine carbapenemase- and metallo-β-lactamase–producing isolates (SIDERO-WT-2014 study). Int J Antimicrob Agents. 2019;53(2):177-184. doi:10.1016/j-ijantimicag.2018.10.007
Hackel M, Tsuji M, Echols R, Sahm D. In vitro antibacterial activity of cefiderocol (S-649266) against gram-negative clinical strains collected in North America and Europe (SIDERO-WT-2014 study). Poster presented at: IDWeek [infectious diseases meeting] 2016; October 26-30, 2016; New Orleans, LA. Poster 1828.
Tsuji M, Hackel M, Yamano Y, et al. Cefiderocol in vitro activity against gram-negative clinical isolates collected in Europe: results from three SIDERO-WT surveillance studies between 2014-2017. Poster presented at: 29th European Congress of Clinical Microbiology and Infectious Diseases; April 13-16, 2019; Amsterdam, Netherlands. Poster 1852.
Tsuji M, Hackel M, Echols R, et al. In vitro antibacterial activity of cefiderocol against gram-negative clinical strains collected in North America and Europe, SIDERO-WT-2016. Poster presented at: American Society of Microbiology Annual Meeting (ASM-Microbe); June 20-24, 2019; San Francisco, CA. Poster AAR-767.
Hackel MA, Tsuji M, Yamano Y, et al. In vitro activity of the siderophore cephalosporin, cefiderocol, against carbapenem-nonsusceptible and multidrug-resistant isolates of Gram-negative bacilli collected worldwide in 2014 to 2016. Antimicrob Agents Chemother. 2018;62(2):e01968-17. doi:10.1128/AAC.01968-17
Yamano Y, Tsuji M, Echols R, et al. In vitro activity of cefiderocol against globally collected carbapenem resistant gram-negative bacteria including isolates resistant to ceftazidime/avibactam, ceftolozane/tazobactam and colistin: SIDERO-CR-2014/2016 study. Poster presented at: 27th European Congress of Clinical Microbiology and Infectious Diseases; April 22-25, 2017; Vienna, Austria. Poster 1316.
Tsuji M, Hackel M, Echols R, et al. In vitro activity of cefiderocol against globally collected carbapenem-resistant gram-negative bacteria isolated from urinary tract source: SIDERO-CR-2014/2016. Poster presented at: IDWeek 2017 [infectious diseases meeting]; October 4-8, 2017; San Diego, CA. Poster 1199.
Portsmouth S, van Veenhuyzen D, Echols R, et al. Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomized, double-blind, non-inferiority trial. Lancet Infect Dis. 2018;18(12):1319-1328. doi:10.1016/ S1473-3099(18)30554-1
FDA briefing document.meeting of the antimicrobial drugs advisory committee (AMDAC). October 16, 2019. cefiderocol injection. FDA. Accessed August 4, 2020. https://www.fda.gov/media/131703/download
Fetroja. Prescribing information. Shionogi; 2019. Accessed x x, 2020. https://www.xxxx[GT4]
Matsunaga Y, Echols R, Katsube T, et al. Cefiderocol (S-649266) for nosocomial pneumonia caused by gram-negative pathogens: study design of APEKS-NP, a phase 3 double-blind parallel-group randomized clinical trial. Abstract presented at: American Thoracic Society International Conference, San Diego, California, 18-23 May 2018. Abstract B42.
RCT [randomized controlled trial] [of] Cefiderocol vs BAT [best available therapy] for Treatment of Gram Negative BSI [bloodstream infections] (GAMECHANGER). ClinicalTrials.gov. Updated November 25, 2019. Accessed August 4, 2020. https://clinicaltrials.gov/ct2/show/NCT03869437
Edgeworth JD, Merante D, Patel S, et al. Compassionate use of cefiderocol as adjunctive treatment of native aortic valve endocarditis due to extremely drug-resistant Pseudomonas aeruginosa. Clin Infect Dis. 2019;68(11):1932-1934. doi:10.1093/cid/ciy963
Trecarichi EM, Quirino A, Scaglione V, et al; IMAGES Group. Successful treatment with cefiderocol for compassionate use in a critically ill patient with XDR Acinetobacter baumannii and KPC-producing Klebsiella pneumoniae: a case report. J Antimicrob Chemother. 2019;74(11):3399-3401. doi:10.1093/jac/dkz318
Stevens RW, Clancy M. Compassionate use of cefiderocol in the treatment of an intraabdominal infection due to multidrug-resistant Pseudomonas aeruginosa: a case report. Pharmacotherapy. 2019;39(11):1113-1118. doi:10.1002/phar.2334
Alamarat ZI, Babic J, Tran TT, et al. Long term compassionate use of cefiderocol to treat chronic osteomyelitis caused by extensively drug-resistant Pseudomonas aeruginosa and extended-spectrum-β-lactamase-producing Klebsiella pneumoniae in a pediatric patient. Antimicrob Agents Chemother. 2020;64(4):e01872-19. doi:10.1128/AAC.01872-19


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A CE Júpiter, teljes nevén Club Esportiu Júpiter egy spanyol labdarúgócsapat. A klubot 1909-ben alapították, néhány éve már csak különböző regionális bajnokságokban szerepel. Székhelye Barcelona városa.

Statisztika

Ismertebb játékosok

  Crisant Bosch
  José Parra
  Joaquim Rifé

Külső hivatkozások
 Hivatalos weboldal

Barcelonai labdarúgócsapatok
1909-ben alapított labdarúgócsapatok

redpajama_set_name: RedPajamaWikipedia


text:
The Best First Grade Read Alouds
There's no better way to get kids talking about, laughing at, and interested in books than a good read aloud. Some books just come alive when read aloud to a group of eager ears and eyes. These are some of my favorites!
1ST GRADE READ ALOUDS
Sam and Dave Dig a Hole
Sam and Dave are digging a hole to find something spectacular. They dig and dig and dig, but find nothing. After a lot of work, the boys take a rest, and something quite spectacular happens.
Kids will laugh out loud as the boys dig and miss finding anything spectacular (they are often oh-so-close). It's also a great read for examining illustrations. Subtle differences from the beginning to the end of the book make a big difference!
Wolfie the Bunny
The Bunny family adopts a new son, but their daughter Dot is not impressed. In fact, she's worried because her new brother is a wolf! She tries to warn her parents that Wolfie will eat them all up, but her parents are too smitten with Wolfie to listen. One day it is Wolfie, not Dot, who is threatened. Can Dot help her new brother?
The Thing Lou Couldn't Do
Lou and her friends love adventure! Building fortresses, rescuing wild animals, being race car drivers, or being a deep sea diver - it's what they do. But when a pirate adventure needs a ship, and their ship is up in a tree, Lou knows she'll have to sit this one out. She's never climbed a tree before and she doesn't think she can. She avoids the ship, she makes excuses, and she comes up with SO MANY REASONS not to try. Lou simply cannot climb that tree.
Her friends, however, finally give her the oomph she needs to try and climb. And as Lou grabs on and starts to climb, she struggles and she pulls herself and... she doesn't make it. But that's okay. As she and her friends run off to play a new game, she knows she'll try to climb that tree again.
Click, Clack, Moo: Cows That Type
Farmer Brown has a big problem! His cows learned to type and now they are typing out demands and going on strike until they get what they want. When other farm animals join in, the problem only escalates.
Kids love the humor and repetition: click, clack, moo.
The Digger and the Flower
Digger, Crane, and Dozer work hard every day to build tall buildings, bridges, and roads. But when Digger finds a blue flower in the middle of their rubble, he stops to care for it. When the city is full of buildings and there is only one spot left to fill, Dozer starts his engine and cuts the flower down before Digger can protest. Digger then sets out on a new course, away from the city, to salvage what remains of the flower.
That Is Not a Good Idea
A hungry fox invites a mother goose to dinner. As they trek closer to the fox's house, the mother's goslings repeated warn and shout that it is "really not a good idea!"
With great illustrations, repetition, and a twist ending, kids love reading and re-reading this book!
There Was an Old Lady Who Swallowed Fly Guy
Kids love the easy to read Fly Guy Series! This book puts a spin on the "There was an old lady who swallowed a fly" story. When Buzz and his pet fly Fly Guy go to Grandma's house, she accidentally swallows Fly Guy… and then a spider and then a cat and so on. It's a great combination of an old nursery rhyme and an introduction to a new series kids love to dive into.
Duncan wants to color, but when he opens his box of crayons, no colors can be found. Instead, he only finds letters from each color telling him they've had enough and are done! Orange and yellow are arguing over the correct color of the sun. Black wants to be used more often. Every crayon has a reason. What can Duncan do?
*Bonus Book: The Day The Crayons Came Home
Iggy Peck, Architect
Iggy Peck loves building! Iggy also loves building with a variety of creative materials – peaches, apples, dirty diapers? Unfortunately, his teacher states that she doesn't like architecture. This only helps Iggy realize how much he loves it and how important building is to him, revealing the theme of the importance of pursuing your passion.
*Bonus Book: Ada Twist, Scientist & Rosie Revere, Engineer
The True Story of the Three Little Pigs
Everyone has heard the story of the three little pigs, but have you ever heard the wolf's side of the story? You might not know all the facts, and Alexander T. Wolf would like to explain how this big misunderstanding happened.
Kids (and adults) love hearing the wolf's spin on how he is actually innocent in this fairy-tale remake.
Everyone knows how Humpty Dumpty fell off that wall, but have you ever wondered what happened after? This book is about picking up the pieces after an accident. Our stories don't stop when we make mistakes. What matters is what happens after we get back up.
Jabari Jumps
Jabari is ready to jump off the diving board! But first, he needs to figure out what kind of jump to do. And he should probably stretch, too. Even though Jabari is a great jumper and he's passed his swim test, the diving board is still a little intimidating. With the help of his patient and encouraging father, Jabari prepares himself for the jump.
I Want My Hat Back
The first book in Klassen's hat trilogy:
A bear lost his hat and he wants it back. He very politely asks several animals if they have seen it but no one has (even though the rabbit he asks is wearing a red pointy hat just like his). Just as the bear loses hope that he'll ever find his hat, he realizes he has seen it! The bear charges back to find his hat!
Kids will love the unusual ending to the book and they will love being in on the joke that the rabbit has the bear's hat the whole time.
This Is Not My Hat
The second book in Klassen's hat trilogy:
A little fish wearing a round hat quickly tells the reader that he stole that hat from a big fish. The little fish knows it's wrong to steal, but he rationalizes the theft and isn't worried at all about the big fish finding him. He has a plan.
The little fish's plan doesn't go so well when the big fish tracks him down. Kids have strong reactions to the ending which is left somewhat up to the reader. What do you do when someone steals your hat?
We Found a Hat
The third book in Klassen's hat trilogy:
When two turtles find a hat and it looks good on both of them, they decide they should just leave it there and forget they found it. But one shifty-eyed turtle has other plans.
Like all of Klassen's work, the illustrations are just as important as the text. Kids eagerly wait to see how the turtle balances his desire for the hat and his friendship.
Hannah and Sugar
Every day after school Violet P.'s dog Sugar is waiting to greet her and the other kids. Hannah, however, is scared of dogs and just can't get over that fear. Even as time passes, the fear doesn't go away.
One day, Sugar isn't there. She's missing. Hannah joins in the search for Sugar and actually finds her. Though she is nervous, Hannah is able to push her fear aside and save Sugar.
If You Give the Puffin a Muffin
In a follow-up to The Angry Little Puffin the Puffin is back and he still isn't happy. When the narrator offers the Puffin a muffin, he kindly says, "No thank you," and explains that puffins do not eat muffins. However, the narrator keeps pressing and Puffin's responses go from polite to annoyed.
When Puffin realizes he is in another book without his permission just because puffin and muffin rhyme, he gets angry! He schemes and calls upon friends to get him out of the book. When those attempts don't work, he confronts the author directly to let him know what he thinks of this story he is in.
With its fantastic illustrations and a main character full of personality and opinions, it is sure to be a new favorite!
Harrison P. Spader, Personal Space Invader
Harrison is a hippo who wants to share his love of life with everyone. But he wants to share it a little too much and a little too closely. Harrison doesn't realize how other people feel when he gets into their space. So when he crowds his friends again and again, his dad gets a few calls from concerned parents, teachers, and coaches.
Harrison's dad shows him a neat trick called the Space Saver, and they practice it together. Harrison is so good at the Space Saver he even starts using it when he doesn't need to, which brings up a new set of frustrations from his friends and teachers. With a little more help, Harrison is able to (mostly) leave an appropriate amount of personal space with his friends.
Stinker
Stinker is a smelly dog waiting to be adopted. His story is narrated by an orange cat who thankfully explains on the first page that the book will have a happy ending, a much needed reassurance for kids (or adults) who might otherwise be worried about Stinker's life stuck in the pound.
Though many families and people seem interested in him, Stinker's stink drives everyone away. With the help of his cat narrator, Stinker breaks out of the pound. Is there a human for every dog? Can Stinker find his?
Want More Book Ideas?
on 10:50:00 AM
Labels: Book Lists, Children's Books, Picture Books, Read Alouds
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Tis the season where motivation is lacking; not only with physical activity but most areas of life that benefit our mind, body and spirit. Here are some tips and tricks to stay motivated not just through the holiday season, but all year long as well! 1. Set Goals & Intentions Start with an easily obtainable … Continue reading Motivation Musts.


Beer and nuts go hand in hand and this recipe brings them both together in one, addictive recipe. Hints of grainy mustard help to add some subtle spice. Perfect for St. Patrick's Day, game night, or anytime you need a really great snack.
In a large saucepan, whisk together Guinness, light brown sugar, and mustard. Bring to a boil over medium-high heat. Reduce heat to medium-low and cook until mixture has thickened, 5-10 minutes. Once thickened, add peanuts (pecans or almonds). Stir to coat completely, and continue to cook over low heat just until all of liquid gets absorbed into nuts, another 1-2 minutes.
Remove from heat and transfer nuts to a large baking sheet. Spread out into an even layer (nuts will be sticky and some of nuts will clump, but that's ok). Sprinkle with salt allow to cool completely, stirring and breaking up nuts a bit as they cool. Transfer to a serving bowl and enjoy!
cook's note: The nuts will keep covered for up to 3 days. Because of the syrup, the nuts will continue to clump together even after they've cooled so you'll need to break them apart each time before serving.


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November 2018 Forecast
November 2018 plays sharply to one base. Every one of the month's putative three biggest films is aimed at children, leaving other demographics with a less lucrative if not unimpressive slate. The focus of the month is on legendary brand name characters - Lisbeth Salander, Robin Hood, Rocky Balboa, The Grinch, Gary Hart - as popular culture thrives on, borne back ceaselessly into the past.
1. The Grinch (November 9th)
The Grinch, Theodor Geisel's best-known character, bursts out of the grave to stalk the traumatized citizens of Whoville and their holiday paraphernalia yet once more, in the tradition of Jason Voorhees, Freddy Krueger, and Michael Myers before him.
December 24 is the night he comes home.
This time, it's the power of CGI animation that brings him back, with Illumination Entertainment and Universal Studios at the helm. Geisel (real name: Doctor Seuss) wrote the book in 1957, and then the Grinch's animated television special has never quite left the air since its debut in 1966. It gave inspiration to Ron Howard's live action How the Grinch Stole Christmas, a film that opened on November 17, 2000 to a $55m weekend, and then, by the time the last errant holiday decoration had been removed in February 2001, had earned a sterling total of $260 million to its credit. It was the biggest movie of 2000. And that was the end of an era, just about the last year ever in film history before the hordes of comic book heroes and Lord of the Rings-type fantasy adaptations arrived to take #1 at the box office over and over again.
The 2000 version had some spectacular scenery and intriguingly malnutritious-looking costuming on its Whos, characters who veered into the grotesque even as they remained modestly good-hearted. The film starred Jim Carrey at the height of his absurd-movie face contorting stardom, and while the casting this time is perhaps not as nakedly obvious, it has a certain hindsight logic. The new Grinch is Benedict Cumberbatch, who will provide for a holiday spoiler less hammily malevolent and more chillingly deadpan, if the history of his performances comes through. Unlike, say, Wreck-It Ralph, the rest of the voice credits are not elaborate and lengthy, but they don't lack talent - Rashida Jones plays Cindy Who's mother, and Angela Lansbury, who made her film debut in 1944, is Whoville's Mayor. Long live the queen.
As for the title, the tradition began by The Fast & the Furious (2009) continues, as this CGI-animated remake slits off a couple of words from the longer 2000 moniker and voila, at simply "The Grinch" is ready to be remade with a brand new name.
The Grinch of 2018 begins nice and ripe and early on the 9th, eight days earlier than Grinch 2000. As a holiday film, it'll have a lot of good weekends. And if Mary Poppins (lord, her again, the horror) isn't all that in December, it could even win the entire last third of 2018, even with the number I give it below.
2. Ralph Breaks the Internet (November 21st)
Ralph Breaks the Internet is a jolly-looking CGI animated sequel to what I'm told is a popular and well-made film, fundamentals that in theory would have it winning the month, if The Grinch just didn't carry such an innate and in-built seasonal advantage. This film is a follow-up to Wreck-It Ralph from 2012, and as such is a rare non-Pixar CGI sequel that arrives quite so many years after its original (assume it was worth the wait). Would Ralph Wrecks the Internet have been a more astute title?
John C. Reilly reprises his title role, the pixel-made arcade game mainstay, who six years ago broke free from his digital bonds and explored a vast pop culture world of video game icons. Sarah Silverman returns as his concierge, von Schweetz, and all manner of comedy practitioners provide their voices in support - Bill Hader, Jane Lynch, Ed O'Neill, and the list continues into infinity and beyond, ad Apatow.
As with The Nutcracker below us, Ralph comes from Walt Disney Studios, and should mine the studio's ever-growing toolshed of icons for cameos and cultural mileage. The posters make no secret of the presence in the film of any number of Disney Princesses, a fact that would have excited me... never. But the world, apparently, doesn't revolve around me.
Expect very positive reviews (75% on the Tomato seems a minimum) and a hearty, leggy box office run into early next year.
Opening weekend: $65 million (5-day) / Total gross: $201 million
3. Fantastic Beasts Bite Back (November 16th)
Actually known as Fantastic Beasts: The Crimes of Grindelwald. As with entry #2 here, this is a sequel to a November film that I have somehow, still, neglected to see... (and I've seen at least five Leprechaun movies, so you know I'm comprehensive).
Every single sequel must try to outflank its original, whether in body count, casting, or quality, and the Beasts at the very least try on one front, adding no less than two winners of the People Magazine's Sexiest Man Alive title to their acting roster: Johnny Depp joins the Harry Potter Cinematic Universe as legendarily malfeasant villain Grindelwald, and Jude Law is, yes, a (somewhat younger) Professor Dumbledore, whose murky ageing process need not be addressed here (yes, I know Harry Potter is actually set in the 1980s - and therefore got there with its idea before Stranger Things).
Eddie Redmayne straps on the period attire and magic wand again in the lead, in what is, I suppose, technically the tenth Harry Potter film. His friends and acquaintancees from film number one basically all return - Katherine Waterston and Alison Sudol as feisty New York sisters, Dan Fogler as the series' first major non-supernatural character (a token), and Ezra Miller and Zoë Kravitz as magical sprites on whatever side of the good-evil-other spectrum. I can assume that major cast members from Beasts 1 who do not reprise were killed off (Colin Farrell, dead?).
Fantastic Beasts was the first Potter film set in the United States, a novelty that's shorn off this time around, as the leads head back to Europe to confront their own magic world alternative to World War II in the 1930s. The director, David Yates, can now be said to have directed most Harry Potter films, having been on the job since Order of the Phoenix back in 2007 and gamely showing less exhaustion with the material than I experience just forecasting it.
When Fantastic Beats was released in November 2016, about five years after the last Potter misadventure, I estimated fan fervor at higher-than-existing levels, and perhaps overforecast. I predicted $350m. The real number was $234m. This time around, Grindelwald could set a record, whether it wants to and especailly if it doesn't, as the lowest-grossing film in this extended franchise. But nearly two hundred million dollars ain't chump change.
4. Creed II (November 21st)
Adonis Creed is, as one should instantly recall, the fictional son of fictional boxer Apollo Creed, who was killed in the ring in 1985 (also in the movies) and is still fondly remembered as Rocky Balboa's original antagonist. Adonis reclaimed his father's legacy in a 2015 film that at once resurrected the Rocky franchise, netted Sylvester Stallone his first acting Academy Award nomination since Rocky in 1976, and shifted the series' axis onto another focal point:
Michael B. Jordan, who once more plays Creed, in the second of what could perhaps end up a sixology of films about the character, if history repeats itself (as I often say, the Rocky films are unique as a multi-sequel phenomenon not in the horror, science fiction, or traditional action genres). Jordan was quite scary and effective in his first villain role, over in Black Panther, and here should help punch in an excellent 2018 for himself.
Original Creed director Ryan Coogler does not return to helm this sequel, having been off making something inexplicable (oh, it was Black Panther). Sylvester Stallone is back as Rocky, of course, and since the character barely skated past death's door in the first Creed, it is difficult to predict if he will quite pass by again the second time around. Surely, if there's film number three, he's toast. Tessa Thompson is again the love interest, and the three years since the first have been kind to her movie star status.
The Creed series is about addressing old wounds and rehashing old rivalries, and so it's only natural that in film two Adonis Creed face-off against Viktor Drago, the son of the man who killed his father in the ring, Russian boxer Ivan Drago. Dolph Lundgren reprises his old Drago role, and it's heartening to see him in a major film again (he was also one of the Expendables); first-time Romanian actor Florian Munteanu joins as his son (no actual Russians were harmed in the making of this film). Rocky IV, where Balboa faced Drago, was just about Lundgren's first film, so Munteanu may also have a long career to look forward to (those Expendables reboots in the 2040s aren't casting themselves).
Now, when it comes to box office, Creed II has a sort of ace in the hole: its direct ancestor Rocky IV remains the series' biggest title, after opening on basically the same weekend in 1985 as do the Creed films, and totaling with a $127m potluck (yes, Rocky III, which finished with $125m, was thoroughly outflanked). I hope that Rocky IV's most memorable line, "if he dies, he dies," is reprised, as perhaps should be its great cheesy '80 music. I don't know if Creed II will get good reviews (it's certainly quite possible), but its reserved audience goodwill is such that it will do well irregardless.
Also noted: in a sense, Creed II is the eighth Rocky film, though Rocky Balboa (2006) may be the last one in the series to bear that man's name. I propose, in the tradition of Halloween (2018), that some day they could make Rocky (2026), which again stars Stallone, and ignores everything that happened in the series since the closing credits of the very first film in 1976, with Balboa facing off against Apollo Creed for the first time since the first time. So see Creed II while it still exists.
Opening weekend: $52 million (five-day) / Total gross: $122 million
5. Bohemian Rhapsody (November 2nd)
Bohemian Rhapsody was a 1975 single by Queen, the English rock and roll band of the 1970s and 1980s, known for period attire and exceptionally declarative ballads. It is now a film bearing the same title. The star of the show, then as now, is frontman Freddie Mercury, who led Queen into superstardom and achieved rock immortality before dying of AIDS in 1991.
I may be a big disgrace, but my extensive mental database does not include much information about Queen aside from a few macho song titles vaguely jaggling around in that brain ("We are the Champions," "We Will Rock You," "Another One Bites the Dust"). But I do sense that, as uncommon as it is for biopics, even musical ones, Bohemian Rhapsody is likely to go forth more as a fan rushout film than an awards contender.
Mercury is played by Rami Malek, known by me as the kindly Pharaoh Ahkmenrah in the Night at the Museum films, and by many others for starring in, but not as, Mr. Robot on television. Among his band mates here are Ben Hardy (Angel from X-Men: Apocalypse) and Joseph Mazzello, who as a child actor starred in everything from Jurassic Park to Simon Birch to Star Kid, and who lately has been consigned merely to supporting work in The Social Network and a G.I. Joe sequel. The film had some behind-the-scenes excitement (Bryan Singer is still credited as director, though Dexter Fletcher did much of the job) and an even longer production history before that (Sacha Baron Cohen was attached to star at one point, completely irony-free). But all is now in the past, as Bohemian Rhapsody arrives on the magnetic buzz of its lead character/actor, and trailers that highlight the film's appeal in IMAX exhibitions, with music that's felt as it is heard. That's enough for Bohemian Rhapsody to coast on for a solid weekend or two.
6. Widows (November 16th)
Four women whose husbands die in the midst of a robbery conspire to finish the job, with bad guys and police on their posterior (armed robbery is technically illegal. I checked).
Widows is the latest from Steve McQueen, previously the director of somber, important artistic films Hunger (2008), Shame (2011), and his Best Picture-winning masterwork, 12 Years a Slave (2013). Widows is somber, too, and might be important - class, race, and economic disenfranchisement are unavoidable topics even in a commercial package.
Viola Davis leads the team of women, with the strength and ferocity she brings to her authority figure roles in Suicide Squad and How I Met Your Mother How to Get Away with Murder. Her co-horts in redemptive thievery are Michelle Rodriguez, in another of the cascade of no-nonsense roles she's carried since 2000; Elizabeth Debicki, towering above it all; and Cynthia Erivo, who was very good as the soul singer in last month's Bad Times at the El Royale, a film I decidedly recommend.
In support are Liam Neeson as Davis' husband, Jon Bernthal as Rodriguez', Robert Duvall and Colin Farrell playing a father-and-son pair prone to suspicious behaviour, and Daniel Kaluuya (the Oscar nominee from Get Out) as an enforcer on Davis' trail. In short, as this exhaustive laundry list of impressive names indicates, Widows has quite a lot going for it: cast, director, and reviews (ninety something mega-fresh), a trifecta for a film taking on the kind of mid-November slate inhabited by a lot of recent, meaty, awards contenders; and in her role as a grieving woman taking violent action into her own hands, Davis recalls another of those titles, Three Billboards Outside Ebbing, Missouri, with Frances McDormand's righteous anger finding a worthy comrade here.
7. Instant Family (November 16th)
Mark Wahlberg and Rose Byrne play a couple who decide their house is just too big and too empty for the two of them (at least I think that's it), and so adopt three adorable children, led by a teenage girl with the trained skills of a master manipulator (Isabela Moner of Sicario). From that point forward, the script writes itself: conflict, drama, comedy, and moral certitude mix and erupt.
Moved up from 2019 to have more fun with the holiday release frame, Instant Family should follow in the tradition of, say, Dennis Quaid and Rene Russo's Yours, Mine & Ours (2005), a Thanksgiving family release about overwhelmed parents and their eighteen or so offspring, give or take.
Instant Family, too, is presumably aimed at children, a demographic whose attention and limited resources will be in high demand this November, although a broad comedy with no fantasy elements offers a nice and marked contrast to all the special effects and CGI manipulation careening about their galaxy (Beasts, Nutcracker, Grinch, etc.). Wahlberg has established himself as a star of, well, practically anything and everything, having headlined R-rated action and PG-stamped holiday films with equal zest and workmanship. His two Daddy's Home films are probably more popular with their target audience than they are with me, and Instant Family should be a defacto part three. If a part three is something you'd want to sign up for, sign away.
8. The Nutcracker and the Four Realms (November 2nd)
The Four Realms is an addendum that's new to me, but this new film is a big-screen high-budget special effects version of Pyotr Ilyich Tchaikovsky's 1892 Russian ballet The Nutcracker. That piece itself was based on the 1816 story The Nutcracker and the Mouse King, by legendary German genre writer E. T. A. Hoffmann, who would have been the third, gentler Grimm brother had the position become available. On-camera, the story has been told in a couple of minor films (in 1986, 1990, 1993, and 2010), one animated, one starring Macaulay Culkin, and two misc.; it was also occasionally seen on television, but this is the first production that can be described as a major studio film with considerable box office expectations (with remarkable if undesirable consistency, none of those previous film versions I mentioned topped two million dollars in domestic box office. This version has its work cut out for it).
Mackenzie Foy (previously the little spawn of two teenage idols in Twilight) stars as Clara, the Austrian girl of the 1920s who is accosted one Christmas Eve by some kind-hearted supernatural creatures, whom she follows from her Vienna estate down into a world of fantastical abundance. Amping up the action and drama, the film gives big supporting roles to the antagonistic Mother Ginger (Helen Mirren), Keira Knightley as the Sugar Plum Fairy, and several character actors playing all the way to type (Eugenio Derbez and Richard E. Grant as quirky rulers of magical realms, Morgan Freeman as the ever-helpful Drosselmeyer). Misty Copeland and Sergei Polunin add an element of ballet, what they do best.
Through some complex accounting and melodrama, the film has two accredited directors, Joe Johnston, a veteran of more than his share of sturdy PG-rated fantasy (Captain America, Jumanji), and Lasse Hallström, known for lush melodramatic films like The Cider House Rules and Chocolat. Here, they're in charge of a project that wouldn't suffer from a little lushness, melodrama, and sturdiness, separately or in unison. The film's Christmas setting and appeal to smaller, younger, children might limit its opening weekend, but could help it along in the nine or so weekends left until the end of the year, as the malls of America begin more and more to resemble the film's setting.


Kyle is passionate about language learning and teaching through music, which happens to be his personal favorite learning method. He currently studies linguistics in Middlebury, Vermont, but spends all of his free time and money traveling and eating well in the meantime. He has big dreams of inspiring as many people as possible to learn languages through music by showing them how much more fun and efficient of a method it is. To pay for all this, he teaches English and German on italki and is constantly thinking of new ways to encourage everyone to learn languages in the way that best suits them.


1 What Causes Pet Allergies?
2 Are Some Pets Better for Allergies than Others?
3 How Can You Avoid Getting Rid of a Pet?
4 What is the Best Way to Remove a Pet from the Home?
America is a nation of pet lovers! As a matter of fact, it is estimated that, across the country, Americans have around 100 million pets! They provide comfort, companionship and joy and are an important part of many households.
This is why pet allergies are such a concern for so many people, especially if there is a child with asthma in the household. For while around 5-10% of the general population has pet allergies, for asthmatic children, the number is closer to 30%. These allergies can cause asthma attacks, which remains the number one reason, nationwide, why parents take kids to the emergency room. This can mean that parents of asthmatic children can face some tough choices when it comes to the question of pets.
Contrary to popular belief, it is not the pet's actual fur that causes an allergic reaction. People are actually allergic to the proteins found in the pet's dried saliva, urine and dander (which is a medical term for sloughed-off dead skin cells). The pet's fur can also harbor other allergens like dust mites, mold and pollen. A child who hugs or kiss a pet, sleeps near them or even just pets them can breathe these airborne allergens in or can transfer them through the hands by eating food or rubbing the nose or eyes without first washing the hands.
Are Some Pets Better for Allergies than Others?
To begin with, parents and children need to both understand that there is no such thing as a hypoallergenic pet: all cats and dogs shed these proteins from urine, saliva and dead skin cells. However, there are some breeds of cats and dogs which can reduce the amount of allergens a child is exposed to. Terriers, poodles and other breeds which do not develop (and shed) winter coats and some cat species like Siberian or Russian blues do shed less. For some kids, choosing a breed like this can make it more likely that they will be able to keep their pets. Some children are so allergic, however, that any breed can cause a reaction.
How Can You Avoid Getting Rid of a Pet?
Wash your pet or wipe them down with a damp cloth twice a week; it has been shown that a twice weekly treatment can help reduce dander by as much as 85%.
Teach your child to wash hands after playing with a pet; if you have an outdoor pet, then if possible have them remove their clothes in the laundry room and take a quick shower when coming in from playing with the pet to avoid tracking any dander into their bedrooms.
Make sure your child's allergies and asthma are under control with some combination of oral antihistamines (like Zyrtec), nasal sprays, eye drops, asthma inhalers and, if needed, long-term immunotherapy (allergy shots). You and your doctor can sit down and talk about what combination of medications will best meet your child's needs.
In short, keeping a pet when your asthmatic child has a pet allergy can mean a lot of extra work. Also, for some kids, even if parents follow the guidelines above, the allergies are so strong that they can simply not be around pets without developing a reaction, in which case you will have to go to the next level and remove the pet from the home.
What is the Best Way to Remove a Pet from the Home?
In short, pet allergies – especially with more vulnerable, asthmatic children – are difficult to deal with, whether that involves trying to keep the family pet or find it a new home. For some children, however, simply reducing exposure and making sure that allergies and asthma are medically managed can be enough to contain the problem!


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Obituaries for the week of October 25, 2017
By Atmore Newsaccess_time5 years ago
Timmy Joe Sprinkle
Mr. Timmy Joe Sprinkle, age 32, passed away Sunday, October 15, 2017 in Atmore, Ala. He was a native and life-long resident of Bay Minette, Ala.
He was preceded in death by his mother, Peggy Sue Morrow and sister, Donna Joe Cooley.
Mr. Sprinkle is survived by his father, Emmette Philyaw of Bay Minette; three brothers, Richard Sprinkle, Shane Philyaw and Matthew Sprinkle, all of Bay Minette; one sister, Angie Lynn Davidson (Maurice Daniels) of Bay Minette.
Funeral services were held Friday, October 20, 2017 at 10 a.m. at Petty-Eastside Chapel Funeral Home with Sis. Helen Stewart officiating. Burial followed at Oak Hill Cemetery.
The family received friends Friday, October 20, 2017 from 9 a.m. until service time at 10 a.m. at Petty-Eastside Chapel Funeral Home.
Pallbearers were Jr Sprinkle, James Brown, Maurice Daniels, Shane Philyaw, Matthew Sprinkle, Mark Marrow, James Ray and Terry Philyaw.
Petty-Eastside Chapel Funeral Homes, LLC in charge of all arrangements, Atmore, Ala.
A.J. Mathews
Mr. A.J. Mathews, age 72, passed away Sunday, October 15, 2017 in Winston-Salem, N. C. He was a native of Delhi, La., former resident of McMinnville, Tenn. and has resided in Clemmons, N.C. for the past year. He had forty-one years of service in the garment industry where he served as president and vice-president.
He was preceded in death by his wife, Beverly Mathews; parents, Lonzey and Lula Mathews; four sisters, Juanita Williams, Christine Duckworth, Lonette Guice and Judy Butler; three brothers, L.C. Mathews, John Macklon Mathews and C.T. Mathews.
Mr. Mathews is survived by two sons, Dana Allen (Tracy) Mathews of Murfreesboro, Tenn. and Scott Clyde (Denise) Mathews of Winston-Salem; one brother, Donnie Joe (Deanna) Mathews of Louisiana; two sisters, Joan (Mitchell) Hale of Louisiana and Sharon (Jim) Fenwick of Ohio; sister-in-law, Francis Mathews of West Virginia; brother-in-law, Malcomb Butler of Louisiana and two grandchildren, Daniel and Christopher.
Funeral services were held Saturday, October 21, 2017 at 10 a.m. at Petty-Eastside Chapel Funeral Home with Rev. Earl Harrison and Rev. Eric Bryan officiating. Burial followed at Oak Hill Cemetery.
The family received friends Saturday, October 21, 2017 from 9 until service time at 10 a.m. at Petty-Eastside Chapel Funeral Home.
Pallbearers were Dana Mathews, Scott Mathews, Donnie Joe Mathews, Mitchell Hale, Malcomb Butler and Mike Duckworth.
Clinton Cole Gregson
Mr. Clinton Cole Gregson, age 20, passed away Monday, October 16, 2017 in Atmore, Ala. He was a native of Monroeville, Ala. and has resided in Uriah, Ala. most of his life. He was a member of the Goodway Church of Jesus Christ of Latter-day Saints.
He was survived by his father, Clint Gregson of Uriah; mother, Donna Marie Pierce of Tenn.; grandparents, Bernie and Joanna Gregson of Uriah and Elaine Lyons of Knoxville, Tenn.; half- brother, Austin Weatherly of Knoxville; sister, Brooke Ann Gregson of Knoxville; fiancé, Ashley Fountain of Uriah and numerous aunts, uncles other relatives and many friends.
Funeral services were held Friday, October 20, 2017 at 3 p.m. at Goodway Church of Jesus Christ of Latter-day Saints with Elder Greg Fralick and Elder Edward Glade officiating. Burial followed at Poplar Springs Cemetery.
Family received friends Friday, October 20, 2017 from 2 p.m. until service time at 3 p.m. at the Goodway Church of Jesus Christ of Latter-day Saints.
Pallbearers were Kyle Fralick, Tripp Gibson, Austin Gregson, Blake Gregson, Austin Weatherly, Cooper Dean, Kyle Williams and Tyler Gregson.
Marilyn Stewart Anderson
Mrs. Marilyn Stewart Anderson, age 71, passed away Thursday, October 19, 2017 in Rabun, Ala. She was a native and resident of Rabun. She was a member of the Fretwell Tabernacle Holiness Church.
She was preceded in death by her parents, Woodrow and Sadie Stewart; son, James "Trey" Long, III; brother, Billy Stewart; sister, Betty Allen and step-daughter, Shelly Thead.
Mrs. Anderson is survived by her two daughters, Teresa and Chris Vanderkooi of St. Petersburg, Fla. and Connie Long of Rabun; one step-daughter, Shelia and Lee McGuire of Tyler, Texas; three brothers, Burk and Lucille Stewart, Jerry and Carolyn Stewart and Rocky and Shelia Stewart, all of Rabun; six sisters, Barbara and Rayford Hadley, Sherry Jean Ryan, Joal Linette Thomas, Janice and Alonzo Sims and Shelia and Bryan Foster, all of Rabun and Margie and Steve Doyle of Crossroads, Ala.; four grandchildren, Briannia, Jett, Josh and Alex; five step-grandchildren; one great-grandchild, Harper; eleven step-great-grandchildren and eight step-great-great-grandchildren.
Funeral services were held Monday, October 23, 2017 at 2 p.m. at Petty-Eastside Chapel Funeral Home with Sis. Helen Stewart officiating. Burial followed at Dean Cemetery.
The family received friends Monday, October 23, 2017 from 12:30 p.m. until service time at 2 p.m. at Petty-Eastside Chapel Funeral Home.
Pallbearers were Kory Doyle, Derek Doyle, Lonnie Sims, Garrett Franklin, Shane Stewart and Kyle Presley.
Erma Estelle Higdon
Mrs. Erma Estelle Higdon, age 89, passed away Thursday, October 19, 2017 in Montevallo, Ala. She was a native of Bratt, Fla. and has resided in Atmore, Ala. most of her life. She was a member of the True Hope Fellowship.
She is preceded in death by her parents, George and Celia Dockens and her husband, Bryan Higdon.
Mrs. Higdon is survived by her two daughters, Emily and Jim Allen of London, Ky. and Marty and Jack Beeman of Montevallo, Ala.; five grandchildren, Heather, Jacob, Michael, Caleb and Kelly and ten great-grandchildren, Rylee, Reese, Rowan, Georgia, Hadley, Emma, Max, Drew, Shontel and Josh.
Funeral services were held Tuesday, October 24, 2017 at noon at Petty-Eastside Chapel Funeral Home with Bro. Doug Coburn and Bro. Jimmy Dukes officiating. Burial followed at Judson Baptist Cemetery.
The family received friends Tuesday, October 24, 2017 from 11 a.m. until service time at noon at Petty-Eastside Chapel Funeral Home.
Pallbearers were Jody Hardy, Billy Hardy, Jake Beeman, Michael Beeman, Caleb Beeman and Terry Reeves.
Susan Marie Moore
Ms. Susan Marie Moore, 63, of Atmore, Ala., passed away Sunday, October 15, 2017 as a result of an automobile accident. A native of Atmore, she had lived in Virginia and Florida. She enjoyed cooking and talking with family and friends.
She was preceded in death by her parents, Cornelius Rothchild and John Beverly and several siblings.
Ms. Moore is survived by her daughter, Katrena Moore of Norfolk, Va.; her son, Demerice Moore of N. C.; two sisters, Velma Alice Dailey of Atmore and Laura Rollins of Fort Lauderdale, Fla.; one brother, James Moore of Atmore; six grandchildren and eight great- grandchildren; nieces, nephews, and cousins.
Funeral services were held Saturday, October 21, 2017 at 11 a.m. at Longmire-Jones Memorial Chapel of Turner Funeral Chapel with Chief Apostle Carolyn Banks officiating.
Turner Funeral Chapel LLC in charge of all arrangements.
Dennis Odom
Mr. Dennis Odom, age 50, of Flomaton, Ala., passed away Saturday, October 14, 2017 at Baptist Hospital in Pensacola, Fla. A native of Century, Fla., he was a graduate of Flomaton High School and worked in construction.
Mr. Odom is survived by his wife, Mildred Odom of Macon, N. C.; two daughters, Stephanie Odom of Jacksonville, Fla. and Denise Odom of Macon; one son, Dennis Odom of Macon; his mother, Hattie Mae Odom-Lett and step-father, Cecil Lett, Sr. of Brooklyn, N.Y.; three sisters, Katherine (William) Pinkney of Queens, N.Y., Kenya (Robert) English of Century, and Candice (Eric) Moliere of Brooklyn; one brother, Jerry Odom of Flomaton; one grandson; two step-brothers, Cecil Lett, Jr. and Kelvin Lett; two step-sisters, Gloria Lett and Connie Lett, nieces, nephews, and other family and friends.
Funeral services were held Saturday, October 21, 2017 at 2 p.m. at Damascus Baptist Church – Flomaton with Rev. Henry Hawkins, Pastor, officiating. Interment followed in Fannie-Damascus Cemetery.
Torrey T. McNabb
Mr. McNabb, age 40, of Montgomery, Ala., passed away Thursday, October 19, 2017 in Atmore, Ala.
Funeral services are incomplete at this time but will be announced later by Turner Funeral Chapel, LLC.
Olivette Williams
Olivette Williams, age 73, of Atmore, Ala. (Freemanville Community) passed away Saturday, October 21, 2017 at her home.
Public viewing was held Friday, October 27, 2017 from 5 until 7 p.m. at Christian Memorial Funeral Home.
Funeral services were held Saturday, October 28, 2017 at 1 p.m. at Mt. Gillead Missionary Baptist Church. Burial will follow at Fairview Cemetery.
Christian Memorial Funeral Home in charge of all arrangements.
John "Bo" Fields
Mr. John "Bo" Fields, age 48, of Evergreen, Ala., passed away Wednesday, October 18, 2017.
He was preceded in death by his parents, R.C. Fields and Patricia Fields; grandparents, John and Vader Fields.
Mr. Fields is survived by his brothers, Rusty Fields of Hanceville, Ala. and Michael Fields of Evergreen; sisters, Lisa F. (Mike) Acuff of Hanceville and Theresa F. (Chris) Crosby of Evergreen; special friend, Pam Fields and a host of nieces, nephews, cousins and other relatives and friends.
Funeral services were held Saturday, October 21, 2017 at 11 a.m. with Rev. E. J. Waters, Jr., officiating. Interment followed at New Home Church of Christ Cemetery.
Pallbearers were Rusty Fields, Cody Fields, Nick Fields, Tyler Crosby, Todd Driver and Chris Crosby.
Flower bearers were family and friends.
Christian Memorial Funeral Home in charge of all arrangements. Evergreen, Ala.
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The stars were abuzz for the 68th Annual Emmys Awards and I was on hand to spin up their official Nominees and Presenters bash at the Pacific Design Center. The night brought out top nominees like Sarah Paulson, who won for her role in The People Vs OJ Simpson, as well as Cuba Gooding Junior, Regina King, Ru Paul and many more! I spun up crowd favorites like Bruno Mars Uptown Funk and new jams by Sia throwbacks by Michael Jackson and more while rocking out a special Mason By Michelle Mason Polka dot paneled silk dress, Stuart Weitzman studded heels, Gas Bijoux chandelier earrings and a Treesje metallic clutch. Check out the snaps from the big night below.
Shop Mason By Michelle Mason! A Special Thanks for dressing me for the big night!


On this Royal Wedding Day, I present the happy couple with this lovely field of Texas flowers! I just love how flowers don't discriminate…they'll grow wherever their seeds land without regard for their neighbors, their political or religious beliefs, their education, their birth certificate…none of that matters. What really matters is turning their pretty faces toward the sun and soaking up as much as possible. And maybe attracting a bee or two.
So, here's to the newlyweds out there…may you catch a few sunny rays!


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'The Batman' director Matt Reeves ditches Ben Affleck script, has a'new story
Matt Reeves is creating a new script for the upcoming "The Batman," which is set to launch a trilogy. (YouTube/Warner Bros.)
The director is not using the script that Ben Affleck came up with in collaboration with Chris Terrio and Geoff Johns.
July 13, 2017 at 5:32 AM July 13, 2017 at 5:32 AM
DC's "The Batman" has gone through quite a struggle to find its footing with pre-production. Earlier this year, actor Ben Affleck stepped down from his directorial role in the upcoming standalone film that was expected from "Batman v Superman: Dawn of Justice" and this year's "Justice League." Matt Reeves has stepped in to fill the role that Affleck left, and the "War for the Planet of the Apes" director has lofty plans for the upcoming standalone film.
First of all, Reeves is already planning a trilogy, which is unsurprising, as most major superhero movies come in threes nowadays.
Secondly, he's also looking to make it "noir-driven," telling the story from Bruce Wayne's very own eyes. Based on his most recent statements about the film, the news that he dropped Affleck's script is now unsurprising. The 51-year old "Felicity" creator opened up about why he let go of the script that Affleck, Chris Terrio, and DC's Geoff Johns worked on for the film.
Matt Reeves is 'starting again' with the new script
MTV (via The Hollywood Reporter) revealed that "The Batman" director Matt Reeves said that the new script is "a new story. It's just starting again." He added that he is very excited about the new script, which he described as "really cool."
Joe Manganiello's fate as Deathstroke uncertain
With all the changes surrounding "The Batman," it isn't surprising that there's no word yet on Joe Manganiello's casting as Deathstroke.
The actor was cast for the role back when the script required Deathstroke to appear in the film. At this point, director Matt Reeves and star Ben Affleck have not confirmed that Manganiello's Deathstroke will still be in the film.
New 'Justice League' TV spot features the Flash
As fans wait for Ben Affleck's "The Batman" solo outing, the actor will return as Bruce Wayne in this year's "Justice League," which comes out in November.
A new international TV spot for the highly anticipated film has been released, and it features three of the five superheroes. There's Gal Gadot returning as Wonder Woman, Ezra Miller as Flash, and Affleck as Batman. Anticipation is high for fans of "Justice League," as a new trailer is most likely going to be showcased at the upcoming San Diego Comic Con, happening this July 20 and will go through the weekend following that date.
"Justice League" is set to open in theaters this November 17. Check out the new TV Spot trailer below.
Jane Flowers
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Coach Jordan Carlson will also be helping the furthering of fitness at CrossFit Loomis this week. I highly recommend that you get a class with him. A member of our armed forces, Jordan has continually represented very well in his fitness abilities. He has a wealth of knowledge regarding functional movement and mobility. Come and be challenged. You will not regret it.


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Study Unfairly Pegs Selfie Men as Psychos
J.D. Rimann and J.D. Rimann|February 1, 2015
Aaron J. Stewart
A photo illustration depicting the relationship between men who take an abnormal amount of selfies and psychopathy. Modeled by Junior Theater Major Stuart Rial. -Aaron J. Stewart
Both quarterbacks from last night's Super Bowl are avid selfie-takers. According to a new study, both of them, then, likely lean toward narcissism and self-objectification. To that I say: do we really need a study to tell us that Tom Brady is a narcissist?
The word "selfie" could be said to have officially entered the English lexicon in 2012, when TIME Magazine included it on their list of top 10 buzzwords for the year. Three years later it has done more than arrived — it has moved in, settled down and started a family.
Selfies (i.e. pictures taken of oneself, often with a mobile device) have caused international incidents, been the crux of multiple marketing campaigns, inspired the rebranding of the monopod as the "selfie stick" and now even have a TV series (ABC's creatively titled "Selfie") made about them.
All of this attention inspired researchers at The Ohio State University to try to find out just what kind of person it is who takes selfies. Researchers surveyed 800 men ranging in age from 18 to 40, using an online survey that inquired about their photo-posting behavior on social media. The men were also asked to complete standard questionnaires regarding anti-social behaviors and self-objectification. The results: men who often take and post selfies tend toward narcissism, self-objectification and psychopathy.
"It's not surprising that men who post a lot of selfies… are more narcissistic, but this is the first time it has actually been confirmed in a study," said Jesse Fox, lead author of the study and an assistant professor of communication at The Ohio State University.
Students at The University of Southern Mississippi generally agreed.
"Generally someone who takes a lot of selfies has a self-esteem issue as it is," said Alissa Clouse, a junior interior design major. "It could be (caused by) low self-esteem or preoccupation with themselves."
David Jordan, a sophomore business major, said that while "you can't really generalize people who take selfies like that, it is an interesting study nonetheless." I am inclined to agree with Jordan myself. The findings of the study strike me as over-the-top. It is somewhat of a stretch to claim that all men who commonly take and post selfies are psychopaths.
Unless, of course, you think Barack Obama is a narcissistic psychopath. In this case Republicans might completely agree with the study. That is, until being informed that Mitt Romney is also a serial selfie-taker.
Other men who commonly take selfies include Leonardo diCaprio, Jay-Z, George Clooney and Vladimir Putin (the psychopath part is probably spot-on in that last example).
At the end of the day, most every student – male or female – takes at least a couple of selfies a week. It is, by and large, really nothing more than a harmless cultural phenomenon.
Of course, some might take it a little too far. Renowned selfie-taker James Franco wrote an entire op-ed in the New York Times back in 2013 defending his frequent selfie-taking, a column he ended by saying: "I am actually turned off when I look at an (Instagram) account and don't see any selfies, because I want to know whom I'm dealing with." He sounds pretty psychopathic to me.
But then again, I take selfies every day too.
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The battle of the gods has begun! Here we get to have a sneak peak of the upcoming battle between Goku and Bills. Please note that Bills is the weaker of the 12 Gods, that's right 12 Gods that still exist in the DBZ Universe. So expect a new series or movie sequels to appear after this.
Anyway, onto the epic battle between Super Saiyan 3 Goku and the Egyptian God Anubis 'aka' Bills.


ALEXANDRIA, Va. – Jose Lopez Torres, 26, of Falls Church, and Jesus Alejandro Chavez, 25, of Alexandria, were both sentenced today to life in prison for their roles in two murders and one attempted murder in Northern Virginia, among other charges.
According to court records and evidence presented at trial, on Oct. 1, 2013, Torres, along with co-conspirator Jaime Rosales Villegas and others drove to Gar-Field High School in Woodbridge to murder a fellow gang member. However, one of the gang members in the car had not only alerted police to the murder plot, he also recorded phone calls and a meeting during which gang members, including Torres, Villegas, and Pedro Anthony Romero Cruz, who participated from prison on a contraband cell phone, planned the murder. The gang members' vehicle was under surveillance that night, the victim had been warned to not be at school, and the informant was wearing a body wire.
According to court records and evidence presented at trial, on Oct. 7, 2013, Torres, Omar DeJesus Castillo, Juan Carlos Marquez Ayala, Araely Santiago Villanueva, Jose Del Cid, and three others murdered fellow gang member Nelson Omar Quintanilla Trujillo. The gang believed Trujillo was a snitch, and so the gang members lured him to Holmes Run Park in Falls Church, and brutally killed him by stabbing him with knives and slashing him with a machete. When they were done they buried Trujillo in a shallow grave. Several gang members returned a short time later and, with the assistance of Alvin Gaitan Benitez, reburied the body of Trujillo.
According to court records and evidence presented at trial, on June 19, 2014, Jesus Alejandro Chavez, along with Del Cid and Genaro Sen Garcia murdered Julio Urrutia. Several gang members including Chavez, who had been released from prison a mere eight days earlier, were out looking for rival gang members when they approached a group of young men, flashed their gang signs, and challenged them about their gang affiliation. During the exchange Chavez pulled out a gun and shot Urrutia in the neck at point blank range. Urrutia died from the gunshot wound two days later.
A total of 13 defendants were charged in this case. Of those, six defendants went to trial and were convicted of all charges on May 9. Six defendants pleaded guilty prior to trial, and one defendant was severed from the case and will have a separate trial at a later date. Each defendant convicted at trial faces a mandatory sentence of life in prison. Please see the table at the end of this press release for additional information on each defendant.
Dana J. Boente, U.S. Attorney for the Eastern District of Virginia; Paul M. Abbate, Assistant Director in Charge of the FBI's Washington Field Office; Colonel Edwin C. Roessler Jr., Chief of Police, Fairfax County Police Department; Earl L. Cook, Chief of Police, Alexandria City Police Department; and Barry M. Barnard, Chief of Police, Prince William County Police Department, made the announcement after sentencing by U.S. District Judge Gerald Bruce Lee.
Assistant U.S. Attorneys Julia K. Martinez and Tobias D. Tobler are prosecuting the case. The case was investigated by the FBI's Washington Field Office, the Fairfax County Police Department's Gang Investigations Unit, the Prince William County Police Department, and the Alexandria City Police Department.
A copy of this press release may be found on the website of the U.S. Attorney's Office for the Eastern District of Virginia. Related court documents and information may be found on the website of the District Court for the Eastern District of Virginia or on PACER by searching for Case No. 1:14-cr-306.


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Best Nephrology Hospitals in Dubai
Choose from 6 best Nephrology hospitals in Dubai
Kidney Tumor (1)
Top Hospitals For Nephrology In Dubai
Canadian Specialist Hospital, Dubai
Dr. Sulaiman Al-Habib Hospital
Saudi German Hospital
Thumbay Hospital
Dubai, United Arab Emirates - 4 / 5 - (1 Review)
Al Zahra Private Hospital Dubai is a world-class medical facility providing tertiary care in multiple specialties and has attained national and international accreditations. The 187 bedded hospital has state-of-the-art infrastructure and is equipped with top-notch technology, offering basic to complex medical interventions. The hospital has a team of accomplished medical professionals having international reputation along with highly trained support staff team constituting specialized nurses, paramedical team and others. This premier healthcare service provider aims to deliver first-rate quality clinical care to all the patients on a global level.
Bariatric Surgery, Cardiology, Colorectal medicine, Ear Nose & Throat, Endocrinology, Gastroenterology, General Medicine, General Surgery, Hematology, Nephrology, Neurology, Neurosurgery, Nuclear Medicine, Obstetrics & Gynecology, Oncology, Ophthalmology, Orthopedics, Pediatric Cardiology, Plastic Surgery, Pulmonology, Radiation Therapy, Reproductive medicine, Spinal Surgery, Urology, Vascular surgery
Guinness world record for the most blood cholesterol readings in 8 hours.
UAE's Distinguished Hospital Award
Dubai, United Arab Emirates - 4 / 5 - (2 Reviews)
Canadian Specialist Hospital is premier medical facility providing comprehensive tertiary healthcare services and is a referral facility from other healthcare centres in the Middle East. With a capacity of 200 beds, this hospital has more than 300 specialized centre and is one of the largest hospitals in Dubai with world-class infrastructure and advanced technology. The hospital houses a panel of renowned doctors with reliable experience in their field of medical expertise along with a trained support staff to provide immaculate medical care to all the patients.
Canadian Specialist Hospital won Best Hospital for Medical Tourism Award at the DHA Health Awards 2018
Happy Lyfboat Patients
Lwawire Robert Katula traveled from Tanzania to India for Aneurysm Treatment
"My Name is Lwawire Robert Katula. I come from Tanzania. About… two months ago, it was discovered, I would say maybe accidentally, because… I had not gone to the hospital for this aneurysm but I
Mathews Kaoma from Zambia Traveled to India for Heart Treatment
Mathews Kaoma from Zambia Traveled to India for Heart Treatment "For so many years I suffered from a disease that was not known to me. I was being treated in zambia for a wrong disease called spondy
Ibrahim Kharir Traveled from Alfasher, Sudan to India for Medical Treatment
Ibrahim Kharir Traveled from Alfasher, Sudan to India for Medical Treatment I am Ibrahim Karir, from Sudan. I came to India upon the advice of my colleague, Christopher Laker who had been to India. He
Zulekha Hospital Dubai is a reputed multi-specialty hospital, with a capacity of 179 beds encompassing 32 departments and specialties operated under the highly qualified and accomplished set of doctors. This hospital, established in 2004, is a part of Zulekha Healthcare Group which was founded under the esteemed leadership of Dr. Zulekha Daud in 1964 when she started her practice in Sharjah, UAE. Dr. Zulekha has been the winner of the International Women's Day Excellence Award by 'Dhwani', the New Global Indian Excellence Award and the Lifetime Achievement – Healthcare Award for her services and contribution to the healthcare sector.
Bariatric Surgery, Cardiology, Colorectal medicine, Ear Nose & Throat, Endocrinology, Gastroenterology, General Medicine, General Surgery, Nephrology, Neurology, Neurosurgery, Nuclear Medicine, Obstetrics & Gynecology, Oncology, Ophthalmology, Orthopedics, Pediatric Cardiology, Plastic Surgery, Pulmonology, Radiation Therapy, Reproductive medicine, Spinal Surgery, Urology, Vascular surgery
Dubai Quality Awards 2015
The Dubai Chamber CSR Label Award 2014
Unilever MENA Sustainable Living Plan Award 2014
Business Excellence Department of Dubai Economic Development awards the organizations with the "Dubai Quality Award" which has three levels of honors for implementing the EFQM Excellence Model successfully
Dubai Quality Appreciation Award (DQAP) and Dubai Quality Award (DQA) in the year 2007, 2011 and 2014.
Dubai, United Arab Emirates - 3.8 / 5
Dr. Sulaiman Al-Habib Hospital is a 200 bedded state-of-the-art medical facility. The hospital is a part of Dr. Sulaiman Al-Habib Medical Group (HMG), one of the largest private healthcare providers in the Saudi Arabia. The hospital is a multi-disciplinary health centre offering a wide range of medical services and world-class facilities in combination with international standard of quality and clinical excellence. Sulaiman Al-Habib Hospital ensures that all the patients, domestic and international, receive utmost care and reliable medical treatment. The hospital is equipped with the latest medical equipment and technology for diagnostics, therapeutic use, and critical care.
Bariatric Surgery, Cardiology, Dentistry, Ear Nose & Throat, Endocrinology, Gastroenterology, General Surgery, Nephrology, Neurology, Neurosurgery, Obstetrics & Gynecology, Ophthalmology, Orthopedics, Urology, Vascular surgery
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Saudi German Hospital is a multi-specialty hospital offering comprehensive medical facilities, established in 1988 by one of the largest group of healthcare providers - Saudi German Hospital Group (SHG). With a capacity of over 300 beds, the tertiary care hospital offers excellent medical services with outpatient, inpatient and critical care units in a multitude of specialties and departments. The hospital is a world-class internationally accredited medical center operates with advanced curative techniques, state-of-the art centres for excellence, providing high standard clinical care.
HIMSS by Dubai Health Authority
Best Hospital Award 2014 – 9th Edition DHA ( WHTC)
Best Hospital in Medial Tourism – Socrates Awards Ceremony (ITALY)
Asian Patient Safety Awards 2014 (Infection Prevention and Practice )
Best Hospital Award 2015 – Gulf Business Magazine
Best Hospital Award 2016 – 11the Edition DHA ( WHTC)
Best Urgent Care Hospital (Winners Review 2017)
The Most Outstanding Medical Tourism executive of the World
Dubai, United Arab Emirates - 4 / 5
Thumbay Hospital in Dubai is top-class multi-specialty hospital in Dubai providing multidisciplinary medical services, and is owned by Thumbay Group which is one of the largest healthcare providers in the area. The state-of-the-art facility has a capacity of 150 beds and offers excellent outpatient, inpatient and critical care services to the all the patients. The hospital has made its mark in the sector based on international standard quality clinical care offered by the medical experts, nurses, and the support staff at the hospital.
Bariatric Surgery, Cardiology, Colorectal medicine, Dentistry, Ear Nose & Throat, Gastroenterology, General Medicine, General Surgery, Hematology, Nephrology, Neurology, Neurosurgery, Nuclear Medicine, Obstetrics & Gynecology, Oncology, Ophthalmology, Orthopedics, Pediatric Cardiology, Plastic Surgery, Pulmonology, Radiation Therapy, Reproductive medicine, Spinal Surgery, Urology, Vascular surgery
Dubai Quality Appreciation Award
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Dr. Alind Kumar
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There are many innovative automated weeding technologies coming out of Europe. One of these is the autonomous weeding robot being developed by Ecoroboti (Yverdon-les-Bains, Switzerland). The device is lightweight and solar powered. Early prototypes used a spider like, three-axis delta robot to precisely deliver herbicides to target weeds. Videos of the device were futuristic and intriguing to watch. The company has since moved on to a simpler weeding robot equipped with a fixed boom for spot spraying weeds (Fig. 1 & 2). The autonomous robot has some specifications that are plausible for use in Arizona vegetable production. Machine travel speed is 2.2 mph and work rate is 15 acres/day (10 hour day). Spot spray resolution is reasonable at 2.5 inch2 (1.5 x 1.5 inch). This is accomplished using a series of 52 nozzles mounted on an 80 inch wide boom (Fig. 2). The machine uses computer imaging and artificial intelligence for crop/weed differentiation to identify and target weeds.
This past summer, the system was tested in sugar beets in Germany. Results showed the system correctly sprayed about 80% of the weeds. For a first time, real-world, field scale test, this outcome is encouraging.
There are some limitations however. According to product literature, the machine's artificial intelligence system will identify a crop plant as a weed approximately 5% of the time. Given the high value of vegetable crops, killing 5% of the crop as a trade-off for robotically controlling weeds is probably not viable. It should be noted that this level of crop/weed recognition performance is consistent with other artificial intelligence-based systems reported in the literature.
Don't give up hope though. This type of technology is advancing rapidly, and may become feasible in the future. Computing speed and sensor capabilities are advancing all the time. A review of literature indicates that systems that combine 3-D morphology, optical color and accurate location data with deep learning techniques may be a viable approach to reliably differentiate crops from weeds. It will be interesting and exciting to watch this technology as it develops. That's for sure.
As I have mentioned before, automated thinning and weeding technologies are advancing at a very rapid pace. If you know of a new technology that would be of interest and appropriate for this newsletter, please feel free to contact me.
Areawide Insect Trapping Network (September 30, 2020)
DBM captures beginning to increase in all trap locations comparable to previous years during September.
To date, average captures ( < 1 moths / night ) comparable to the 2018-19 growing season
Moths have been most active in the Yuma Valley where they averaged ~ 1 moth/night in the in traps in both the north and south ends of the valley.
Comparisons between paired fields showed that a significantly higher number of adults were trapped in transplants (cabbage and cauliflower) compared to direct seeded broccoli.
Moth activity is 5-fold higher now than this time last year.
We have started our Areawide Insect and DBM Trapping Network for the 2019-20 season.
We have added another trapping location in Bard, CA.
Area wide Insect Trapping Network VegIPM Update, Vol. 11, No. 20, Sep 30, 2020
Corn earworm: Moth activity about normal for September but beginning to increase, particularly in Dome Valley and south Yuma Valley.
Beet armyworm: Moths remain active throughout the desert, especially in Texas Hill and Tacna growing areas- Staring to pick up in the south Yuma Valley.
Cabbage looper: Cabbage looper activity unusually low for mid-late September. Larvae just starting to show up in some fields.
Whitefly: Adult movement has been relatively light and about average for this time of year. Activity highest in Dome Valley.
Aphids: No aphids have been caught on traps thus far. Normal for this time of year. Still early, anticipate they will begin to show up in October.


McDaniel's campaign has challenged the state's GOP orthodoxy.
JACKSON, Miss. — Don't breathe that sigh of relief just yet, Mississippi.
As the tumultuous fight for Sen. Thad Cochran's seat in Washington hurtles toward a close on Tuesday, this bitter reality has started to dawn on Republicans here: The larger battle for power within the Mississippi Republican coalition is only just beginning.
In this deeply Republican, nearly one-party state, the race between Cochran and conservative challenger Chris McDaniel has torn open long-developing divisions within the GOP power structure. The six-term senator and his allies, led by former Gov. Haley Barbour and an army of entrenched figures in Washington and the state capital, have maintained a tight grip on political power in Mississippi since it became a Republican state in the first place.
McDaniel's campaign has challenged that edifice of party orthodoxy. A confrontational conservative who made a name for himself as a sharp-elbowed member of the Legislature, McDaniel has been surrounded in his race by a throng of ideological fellow travelers in the state Senate. They ride on his campaign bus and speak at his rallies. Like McDaniel, they have campaigned against the establishment in Jackson and enjoy support of the tea party — and they may set their sights on higher office as early as next year.
Win or lose this week, conservatives here predict that Mississippi's state elections in 2015 will bring another reckoning for the party. The reality that McDaniel has come so close to unseating Cochran may herald a larger-scale shift in culture for a state where seniority has long been king.
The brimming activist rage over Cochran's efforts to win Democratic crossover votes this week has added an extra shot of determination to the insurgents' efforts. Feeling that they have been opposed at every turn by power brokers in Jackson, including every major sitting GOP official in the state, they are looking to the 2015 elections as the next chance to upend state politics.
Watson said he would be open to challenging one of the state's Republican statewide officials next year, though he declined to say which one. In addition to Gov. Phil Bryant, Lt. Gov. Tate Reeves and auditor Stacey Pickering are among the elected Republicans facing reelection.
On the sidelines of a McDaniel rally last week, conservative state Sen. Tony Smith predicted turbulent times ahead.
Conservative and tea party leaders draw encouragement from the trend in other states where hard-right challengers have won upset victories. In Kentucky, Sen. Rand Paul's surprise victory in a 2010 spurred the rise of Paul-like candidates such as Rep. Tom Massie and state Agriculture Commissioner James Comer. Less than two years after Texas Sen. Ted Cruz mounted a come-from-behind GOP primary campaign, tea party candidates romped in the 2014 state primaries.
The ruptures within the Mississippi GOP are as cultural as they are ideological; they have as much to do with tone and temperament as they do with substantive divisions over policy. McDaniel has attacked his opponents — and the Barbours specifically — for representing Mississippians who are "relatively wealthy or elite in status," while losing touch with the priorities of voters in places like his Jones County home.


Modern society is increasingly dependent on the security and reliability of IT systems and the Internet, but the vulnerability of our digital world is still proved painfully by hacker attacks on networks or databases, computer viruses, internet worms, and trojan horse attacks. In addition to these facts: the more sensible data like online orders, medical data, or electronic cash is transmitted in open networks like the Internet, the more targets exist for such attacks. So computer and network protection must be one of the most important objectives. This includes protection measures on the underlying network level upto the level of applications and data.
Secure Cloud Storage: CloudRAID - Enabling secure and efficient use of public cloud storage services via multi-cloud techniques.
Secure Cloud Access Management - Managing user's access control in enterprise and multi cloud environment.
Anomaly Detection and Security Risk Analysis of Cloud Services - Detecting and mitigating malicious activities in multi-cloud storage systems using security risk-driven techniques.
Timestamping service that provides a secure and certified connection of a time information with an electronic document, e.g. time of publishing, or time of signing.
Our Handbook on WWW was published by Springer in 2004. A multimedia book presentation can be found here.