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Footage of first Parkinson's treatments found after 50 years
Mind 21 January 2016
By Helen Thomson
George Cotzias: Parkinson's pioneer
Bob Peter/ The LIFE Images Collection/Getty
Videos just discovered show the first people ever to be treated for the symptoms of Parkinson's disease. The footage, hidden for half a century, shows Chilean miners with severe movement problems improving on daily doses of L-dopa.
The videos were filmed by George Cotzias at Brookhaven National Laboratory in Upton, New York. In 1963, while studying the toxic effects of manganese in human tissues, Cotzias learned of four workers in the Corral del Quemado mine in Andacollo, Chile, who had developed a syndrome called manganism – which resembled Parkinson's – through inhaling manganese dust.
Cotzias travelled to Chile to include the miners in a trial of leva-dopa, a chemical building block that the body converts into dopamine, low levels of which cause uncontrolled movements in people with Parkinson's. L-dopa was being tested in Parkinson's patients around the same time but with little success – even small amounts caused adverse side-effects that prevented a high enough dose reaching the brain.
The footage clearly shows the severe problems with walking and turning miners had before treatment. After several months of receiving a daily dose of L-dopa, they were able to feed themselves, shave, tie their shoelaces, and run.
A lasting success
"It's a very important part of the history of neurology," says Marcelo Miranda, a researcher at Clinica Las Condes in Santiago, Chile, who found the footage, some of which was shown at a conference in the 1960s, but hasn't been seen since. "It's the only available document of that period that shows the first patients with Parkinson's symptoms treated with L-dopa and their extraordinary response."
Working with Ismael Mena at the Catholic University of Chile, Cotzias showed that L-dopa has a dramatic effect on Parkinson's symptoms. Initially, Cotzias thought the drug would work in a different way. He was hoping L-dopa would reverse the discolouration of a brain area called the substantia nigra, which has also been linked to Parkinson's disease. Instead, the miners improved because L-dopa helped treat their dopamine deficiency.
Cotzias thinks he succeeded where others failed because he built up the miners' dose of L-dopa slowly, observing the effects over a long period of time, which allowed his study to get past the lag-period before L-dopa starts to work.
Afterwards, Cotzias insisted researchers try the same procedure in other people with Parkinson's disease. Once they had seen his videos, they repeated their tests with equal success, and almost 50 years later, L-dopa remains the most effective agent for treating Parkinson's disease.
Journal reference: <i>Neurology</i>, DOI: 10.1212/WNL.0000000000002223
Read more: People with Parkinson's walk again after promising drug trial
Prairie voles still form social bonds without oxytocin sensors in the brain. The findings challenge the long-held belief that the hormone is a crucial part of the bonding process for all mammals
Early relatives of primates lived in the Arctic 52 million years ago
Analysis of fossilised teeth from Ellesmere Island, Canada, reveals that extinct relatives of monkeys and apes reached the Arctic during a period when the climate was hotter


We are a "food consulting company" supporting the development of our franchisees' businesses based on know-how we've created since we started our company.
With our domestic ramen business as well as our franchise business, we are expanding our operations both nationwide and worldwide.
Based on know-how we've been cultivating from the founding period, we will continue to expand globally as a "food consulting company".


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by cool water on August 8, 2022
What is the Future of Hip Hop in 2022 and Beyond?
Hip-hop artists have aced the entertainment industry, from legends and idols to underground trailblazers. Hip-hop culture is slightly different. This recent hip-hop news is about the world's biggest hip-hop festival yielded to its home city. Rolling Loud Miami, which hosted nearly 200,000 attendees, had no shortage of beautiful moments and headline stuff. Now, with chaos in hip-hop fans' minds, this blog wants to break the future trends that may be promising to proppin' in 2022 and beyond.
Future Trends For 2022 Hip-Hop Culture
After such an amazing hip-hop festival, recently, the hip-hop culture has gained more popularity across the nation and love among the fans. Growing up hip-hop news and trends have shaped the industry. Let's have a look at the enlisted trends.
Urban Kids will Be Taking Over and Ruling Hip Hop for Years
The fact is actual! Whether these artists will be coming to the forefront or not, they will be loud and visible in the coming days. At the same time, the exciting and dynamic Hip Hop artists will soon be announced and spot-lighted. From Pusha-T and Lil Baby to Kanye West is set to rock the floor. Urban artists, from the disabled comedian Dani Aditya to Lil Nas X from the LGBTQ community, are ready to make the Hip-Hop industry more inclusive.
Breakdancing Will Be In Every Corner
Breakdancing is already well-known and adored by people everywhere. According to the recent hip-hop news, the visibility of breakdance will skyrocket in the 2024 Olympics in Paris. For the first time, breakdance will be an Olympics sport. Isn't it thrilling? Participants will be trained as a Breakdance Olympic team by choreographers to clear the events, tournaments, and rounds.
Bass-Heavy Dance Rap Continues to Thank Tiktok
Tik Tok is bigger than ever. The platform has pulled out many artists and turned them into Tik Tok stars. Hip-hop producers and many artists have tended to create tracks with a thrilling and catchy beat and danceable hooks. The recent hip-hop news is about how the hip-hop industry is still and will continue to thank the platform, appreciating the culture and praising emerging artists.
The Hip Hop Culture Continues To Spread Thrill & Love To Fans
It's always a thrill to celebrate Hip-hop culture and praise the artists creating milestones. The newest hip-hop news is no less than good news for hip-hop fans as the future trends will continue to admire the industry with talented artists.
Prolific Hip Hop Artist Common to Star as Caster in Upcoming Digital Comic Book Series
by Kiesha Joseph
Is Soledad O'Brien Really Giving Us What's Black In America ?

redpajama_set_name: RedPajamaCommonCrawl


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Girish Chandra Murmu sworn-in as LG of Jammu and Kashmir
The warrant of appointment of Murmu, a 1985 batch IAS officer from Gujarat, was read out by Chief Secretary B V R Subrahmanyam
G C Murmu was on Thursday sworn in as the first lieutenant governor of the union territory of Jammu and Kashmir following the bifurcation of the state into two union territories. The oath of office to Murmu, who will turn 60 next month, was administered by Jammu and Kashmir Chief Justice Gita Mittal at a simple function held at Raj Bhawan at the foothills of the Zaberwan range.
The warrant of appointment of Murmu, a 1985 batch IAS officer from Gujarat, was read out by Chief Secretary B V R Subrahmanyam.
BJP leader Jugal Kishore and Rajya Sabha MP and PDP member Nazir Laway were among the over 250 guests present the function.
J&K Lieutenant Governor
GC Murmu


text:
Eustace Miller
((WATCH TV!)) Washington - California live stream 23 October 2022
Washington vs California Prediction, Game Preview, Live Stream, Odds & PicksWashington Goes for First Road Win vs host California Golden Bears on Two-Game Losing Streak The Washington Huskies try to get their first win away from home this season when they face the host California Golden Bears in a Pac-12 contest on Saturday night. Washington is coming off a win at home against Arizona, snapping a two-game losing streak and putting it in a tie with Oregon State for fifth in the Pac-12 standings. California has lost two in a row and three of four and is among three teams tied for seventh in the conference at 1-2. Before you do your betting online on this contest, check out our in-depth preview. Let's check the latest college football odds, stats, injury reports and college football lines for Washington vs California.
Read More By BetUS Locker Room Staff / October 20, 2022 The Notre Dame Fighting Irish seem destined for a lost season regardless of what happens Saturday when they play the... Read More By Megan Teske / October 20, 2022 Tough losses in conference play in last out Cross-divisional Big 10 opponents meet in Week 8, the Minnesota Golden Gophers... Read More By Ryan Knuppel / October 20, 2022 Red Raiders on Two-Game Slide The West Virginia Mountaineers try for a second straight win when they visit the Texas... Read More By Riley Thomas / October 20, 2022 Strength Against Strength The Iowa Hawkeyes' perilous schedule continues in Week 8 as they will play their third consecutive Top-25... Read More By Matt De Saro / October 20, 2022 The South Carolina Gamecocks (4-2, 1-2) head home in Week 8 to face off against fellow SEC member, the Texas...
Washington vs. California: How to Watch Week 8 MatchupAll betting lines are courtesy of DraftKings Sportsbook. Washington (5-2, 2-2) at California (3-3, 1-2) Date: Saturday, October 22nd Time: 7:30 PM PT Radio: 93. 3 KJR FM TV: ESPN Streaming: Espn. com/live Betting Line: Washington -7. 5, O/U 53. 5.
We've plenty of NCAA football odds for you to consider. Washington Tries To Travel Well The Washington Huskies have had a home-field advantage this season, going 5-0 at Husky Stadium, but they are going to need to have that translate to the road if they're going to stay in contention in the Pac-12 race.
To do that, quarterback Michael Penix Jr. needs to be on his game as he was against Arizona last weekend, when he passed for 516 yards and four touchdowns. "It's not just about what he did statistically, " Washington coach Kalen DeBoer said of Penix after Saturday's win over Arizona. "He just keeps putting the pressure on and leading the charge to help us win the football game. We needed all those points and all those yards that he gave us. " Penix set the school record for passing yards and total yards in a game (529), pushing the Huskies to 608 yards of total offense.
Expected Score: Washington- 31, Cal- 23. *** Other Saturday Pac-12 Games #9 UCLA (6-0, 3-0) at #10 Oregon (5-1, 3-0) Time: 12:30 PM PT TV: FOX Streaming: Foxsports. com/live Betting Line: Oregon -6, O/U 70. Expected Score: Oregon- 38, UCLA- 32. Arizona State (2-4, 1-1) at Stanford (2-4, 0-4) Time: 1:00 PM PT TV: Pac-12 Networks Streaming: Pac-12. com/live Betting Line: Stanford -3, O/U 53. Expected Score: Stanford-28, Arizona State- 25. Colorado (1-5, 1-2) at Oregon State (5-2, 2-2) Time: 5:00 PM PT Betting Line: Oregon State -23.
m. ET Washington vs California Live Stream: ESPN By Jose Rohdin / October 20, 2022 Saturday features a big game between independent schools as BYU plays Liberty. BYU travels to Virginia as the favorite in... Read More By Ryan Knuppel / October 20, 2022 Colorado Off the Schneid The Colorado Buffaloes, fresh off their first win of the season, visit the Oregon St. Beavers... Read More By Matt De Saro / October 20, 2022 The No. 14 Syracuse Orange look to continue a truly improbable (6-0) start to their season with a road showdown... Read More By Derrick Erickson / October 20, 2022 The Duke Blue Devils and Miami Hurricanes are part of a muddled and complicated picture in the ACC Coastal Division....
Washington vs. Cal: How to watch online, live stream info With earthTV's live webcam Washington D.C.., you can visit Washington D.C. live online and enjoy The White House and other
National Data Buoy Center APL-UW, University of Washington Applied Physics Laboratory. Australian Bureau of Meteorology. Brazilian Navy Hydrographic Center. California
If California is going to contend against the explosive Huskies, it will need a much better performance from its offense. Quarterback Jack Plummer had 262 passing yards and a touchdown in last week's loss, but he also threw an interception for just the third time all season. The senior has passed for 1, 509 yards and nine touchdowns. The Golden Bears will need to run the ball successfully to keep Washington's offense off the field on Saturday. Freshman Jadyn Ott had 274 yards on 19 carries in the win over Arizona, scoring three times, but he's rushed just 33 times for 117 yards in the two games since.
The junior transfer from Indiana has been outstanding this season, passing for a national-best 2, 560 yards and 20 touchdowns. Sophomore wide receiver Rome Odunze was the recipient of much of Penix's attention against Arizona, as he finished with nine catches for 169 yards and two touchdowns. It was the fourth straight game of at least eight catches and 115 yards for Odunze, who has 44 catches for 693 yards and six touchdowns on the season. Offense Lacking For California In Losses The California Golden Bears are averaging 23. 7 points per game and put up 49 in a win over Arizona on Sept. 24, but in the two games since that victory, the Bears have scored a total of 22 points. Not surprisingly, both games ended in losses for California, including last weekend's 13-9 overtime setback to previously-winless Colorado.
Read More By Matt De Saro / October 20, 2022 The Kansas Jayhawks (5-2) and Baylor Bears (3-3) are Big 12 rivals with surprisingly similar seasons through seven weeks. Both... Read More Washington vs California Betting Lines Washington vs California Prediction The Washington Huskies have been one of the more explosive offenses in the country this season, and that should come through again against the California Golden Bears. The Huskies finally get their first road win, routing the host Bears.
California has taken care of the football this season, fumbling just twice and losing only one to lead the Pac-12 in both categories. That will only help the Bears against the opportunistic Washington defense. Washington vs California Game Injuries Washington vs California Head-To-Head If Saturday's contest is anything like last year's meeting between the Washington Huskies and the California Golden Bears, fans will be in for a treat. Washington won a 31-24 overtime contest after California rallied from a 14-point third-quarter deficit. That snapped a two-game winning streak by the Golden Bears against the Huskies, though Washington has an all-time 55-41-4 advantage against California. The college football lines for Saturday's contest are favoring the visiting Huskies to win easily. Washington vs California Game Information Game: Washington (5-2, 2-2 Pac-12) vs California (3-3, 1-2 Pac-12) Location: California Memorial Stadium Day/Time: Saturday, 10:30 p.
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German journal on Ancient Egypt.
Local Egyptology society web-site, in North-west Great Britain, with Egyptological information, musings, reviews, links to other British Egyptology societies and other Egyptological resource.
Information about gods, goddesses, pharaohs, dynasties and symbols of Ancient Egypt.
A 3D reconstruction of the Giza Necropolis, based on the "Giza Archives Project". It gives a very informative overview of the Giza Plateau and all its features. Roam at will in 3D throughout the Necropolis, follow guided tours of the monuments, and browse all the pictures and collected objects meticulously reconstructed in 3D.


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Opinion » Letters to the Editor
Another Equal Rights Victory
America's "heartland" is all "heart" and "mind." Iowa's Supreme Court legalized gay marriage! It wasn't a case of "4 to 3", liberals versus conservatives, it
by Eric Flowers
America's "heartland" is all "heart" and "mind." Iowa's Supreme Court legalized gay marriage! It wasn't a case of "4 to 3", liberals versus conservatives, it was a unanimous decision upholding a lower-court's rejection of marriage being between one man and one woman. The decision language was brilliant: "We are firmly convinced the exclusion of gay and lesbian people from the institution of civil marriage does not substantially further any important governmental objective." Also, the Iowa lawmakers have "excluded a historically disfavored class of persons from a supremely important civil institution without a constitutionally sufficient justification," and any other decision "would be an abdication of our constitutional duty."
Oregon's Bill of Rights states: "No law shall be passed granting...privileges, or immunities, which...shall not equally belong to all citizens." I suggest Oregon's Supreme Court is guilty of abdicating their "constitutional duty." Prejudice must not negate equal human rights - ever! Those who oppose gay marriage, also oppose their own state constitutions! But wait, there's more. Vermont's legislators on Tuesday (Apr. 7) approved gay marriage with an override vote to counter the Governor's threatened veto! What's important here is that this was a legislative act, not a Supreme Court decision as was the case in Massachusetts, Connecticut and Iowa.
Bills are on the books before the legislatures to allow gay marriage in Maine, New Hampshire, New York and New Jersey. If those states approve gay marriage, that would be eight states and if California and Oregon come through, it would be ten states or 20 percent. There may be a landslide coming! Hear! Hear! for the gay communities throughout the country. It's about time.
Bob Bates
Eric Flowers
More by Eric Flowers
The Year the Music Died
The music industry took a big hit in 2020. Will it roar back in 2021?
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Letters to the Editor 12/31/20


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Divya Khosla Kumar: World would be so dry without women
Actress and filmmaker Divya Khosla Kumar feels the world would be so dry without women, adding that several women around her are very inspiring.
"I feel so proud being a woman because it's such a beautiful thing to be born as a woman. I think men can never understand how beautiful it is to be born as a woman because you are gentle, you are so caring and there is so much you give and so much love you spread in the world. I think the world would be so dry without women. I can't even imagine a world like that," said Divya.
"You feel very emotional and proud about the fact that you are a woman. You feel proud when you look at the women around you and when you see that they are so inspiring. I think in today's time each woman is adding to the world. I get inspired all the time from women around me."
Divya, who acted in films such as "Love Today", "Ab Tumhare Hawale Watan Saathiyo" and the short film "Bulbul", is the wife of Bhushan Kumar, the chairman and managing director of T-Series. They have a son, Ruhaan.
She has also directed the films "Yaariyan" and "Sanam Re", both produced by Bhushan Kumar.
Asked if it is easy for a woman to make it to the top on her own, she replied: "Nothing is easy and I don't think it's a gender thing because in any field you work you have to put in hard work and your passion. In the same field, you compete with men and other women, so, your strength, your desire to be there, your passion and hard work matter more than anything. I don't feel it's a gender thing."
Divya will next be seen on screen in the John Abraham-starrer "Satyameva Jayate 2", which is slated to release on October 2. "I am paired opposite John. I am really excited about the film. It's a patriotic film. I don't want to reveal much about it but I am just excited for my role," she said.
"Satyameva Jayate 2" is a vigilante action film and a sequel of the 2018 film "Satyameva Jayate". The film is co-produced by Bhushan Kumar and Nikkhil Advani, and directed by Milap Zaveri. - IANS
Divya Khosla Kumar
Milap Zaveri
Kajol: Understood my mother after I had my daughter
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You & I Magazine Ugadi Special - With Nitya Naresh, Vasavi Reddy and Pallavi Bhoopal Coondoo
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To explain the present importance of surgery in TB management.
To describe the indications for surgery.
To discuss the different stages of surgery, along with important points to consider.
To present examples of data from one institution to help demonstrate the issues to be considered in surgical management.
Summary Surgery remains an important adjunctive method in the treatment of MDR-TB. In this article, adapted from the European Respiratory Society (ERS) School Course on "Multi-resistant tuberculosis and atypical mycobacterial disease", held at the 2004 ERS congress in Glasgow, the indications for surgical management in patients with MDR-TB are discussed, together with data from 75 patients with MDR-TB operated on in the Sureyyapasa Thoracic and Cardiovascular Diseases Teaching Hospital, Turkey, between 1993 and 2003.


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Creating and editing payroll profiles
How to select the National Insurance contribution basis in a limited company director's payroll profile
This article explains how to select the National Insurance contribution basis when creating a payroll profile for a limited company director.
Please note that FreeAgent's payroll functionality won't be available if you have an unincorporated landlord account or if you're preparing your accounts using cash basis accounting.
When setting up payroll in FreeAgent, you will need to create a payroll profile for each employee that will be included on the payroll. This includes choosing a National Insurance contribution basis for limited company directors and entering a directorship starting date (where applicable).
Please note that if the employee is not a director of the company, the information below does not apply. You will need full (level 8) access to FreeAgent in order to create a payroll profile.
National Insurance contribution basis
When you're creating a payroll profile for an individual, the 'Employment Details' section contains information about their National Insurance contribution basis. If the employee is a director of the company you can choose whether to use the 'Director' basis or 'Director (alternative arrangements)' basis.
Regardless of which basis you choose, National Insurance contributions are calculated on earnings above the primary threshold for the employee contributions, and the secondary threshold for the employer contributions.
Director method
Directors have the option to pay their National Insurance cumulatively, so that they pay less at the start of the tax year and more at the end. This means that employee NI will start to be deducted from their salary when their cumulative NICable salary for the tax year to date goes over the primary threshold, and employer NI deducted once their cumulative NICable salary for the tax year to date goes over the secondary threshold. Both of these are calculated on an annual basis.
To select this option for the individual, select the 'Director' option.
Director (alternative arrangements) method
Alternatively, directors can choose to pay their National Insurance monthly, like an employee. This means that each time the director is paid, both the employee and employer NI contributions are calculated based on their monthly pay.
To select this option for the individual, select the 'Director (alternative arrangements)' option.
Whichever method you select, both employee and employer National Insurance contributions will automatically be re-calculated in month 12 on the annual basis ('Director' method) for the Director.
Changing National Insurance contribution basis during the tax year
You can change the National Insurance contribution basis from the 'Director (alternative arrangements)' method to the 'Director' basis during the tax year by updating the individual's payroll profile.
However, HMRC does not allow the National Insurance contribution basis to be changed from the 'Director' method to the 'Director (alternative arrangements)' method during the tax year. This should only be selected when initially creating the payroll profile, or when transferring the profile over to the next tax year.
If the individual leaves the directorship during the tax year but remains an employee of the company, HMRC's guidance is to continue to calculate the National Insurance contributions using the 'Director' or 'Director (alternative arrangements)' method until the end of the tax year. Therefore these changes won't apply until the tax year ends. When transferring the profile over to the next tax year, you can select the 'Employee' basis.
Directorship Starting Date
If the individual became a director of the company during the current tax year, enter the 'Directorship Starting Date'. When a director starts part-way through the tax year, the threshold for how much salary they can receive before they start paying National Insurance contributions is calculated pro rata on a weekly basis. For more information, please refer to HMRC's guidance.
If, at any stage, the employee becomes a director of the company, consider the following when you update this information in their payroll profile:
If the employee is due to be paid again before their directorship start date, don't update the 'NICs calculated as' options until the following month - but make sure you do so before you run that month's payroll.
If the employee is not due to be paid again until after their directorship start date, you should update the 'NICs calculated as' options straight away - make sure you do so before you run the current month's payroll.
How to create a payroll profile
How to edit a payroll profile
How to add an emergency tax code to an employee's payroll profile
How to enable student loan deductions in FreeAgent's payroll


old man entered our care.
cuit and has done an admirable job.
tion of law to each individual case.
— a high for the last three decades.
how that respect was returned to him.
are evident in his law practice.
require many hours per day resting.
for close to 20 years.
qualified candidate for that position.
broad understanding of the law.
No Starting Bids and No Hidden Reserves!
Prices Start at Less than $160 per acre!
and far-reaching effects of the flu.
View Medical Clinic in Enterprise.
tion between Ron Polk and Allen.
witnesses from both sides of the case.
that may arise in court.
to vote for Wes by Nov. 6.


We think we have ironed out all the hardware issues in the two prototype generations. All production units should not have any hardware issues left.
The FPGA currently only contains some basic code to forward samples from the ADC to the SSC of the sam3u. As the ADC clock rate is currently fixed, it needs to do some decimation.
add a mode where samples (or rather: blocks of samples contained in one USB transfer) are time-stamped with a sample counter. Of course this will not work with the standard audio profile, only with options 2+3 above.
power up the device with low clock frequency and all peripherals disabled, as we are only allowed to draw 100mA until the host has selected a configuration that indicates more (e.g. 500 mA). This is to avoid breaking any USB ports e.g. on a bus-powered hub.
Right now the DFU loader doesn't have the capability to flash itself (i.e. the DFU partition). It can only flash the application partition.
Also, there is no way how the flash-based FPGA can be updated yet. This is a bit tricky, as the FPGA image is larger than any of the two flash banks or the RAM inside the sam3u. Also, the FPGA vendor only provides some (soruce code to a) virtual machine + bytecode that runs inside that VM to do bit-banging and flash the FGPA.
devise and implement a method how we can update the FPGA image via DFU or some other custom protocol over USB.
put documentation into the wiki and work on a real user manual.


We provide the following information for you to gather an idea of charges associated with building your website with KMWeb Designs. Because no two sites are ever built the same, it is hard to provide an exact amount of all charges. We are always happy to provide estimates/bids free of charge. Please click here to contact us.
All Of Our Work Is Completed To Your 100% Satisfaction!
When creating a site from scratch or redesigning an existing site, we provide a set amount during the proposal process and as long as the project stays close to the original work agreement, that is what we will charge. We do not charge a page rate or by the hour on initial design. Because each project is different, we can not provide any rate information here, but please contact us for a free proposal.
Please allow 4-6 weeks for the creation of a new site. A 30% fee is applied to any rush request (2-3 weeks).
Minor updates, along with email and phone support, are provided for a period of 30 days after a new site is taken live. After the 30 days have passed, clients are strongly encouraged to purchase a Website Maintenance Contract at a cost of $20.00 per month. Clients who host their site with us will receive a 25% discount at a cost of $15.00 per month.
Unlimited basic site updates at no additional charge. This can include changes to text, changes to images and addition of links.
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Updates are guaranteed to be completed within 48 hours.
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You may cancel your Maintenance Agreement at any time, by giving one month's written notice. A pro-rated refund will be given for any unused period of the advance annual payment.
In the absence of a maintenance agreement, any site updates or modifications will be subject to a $85.00/hour fee. There will be a 30 minute minimum charge for any updates ($42.50).
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We provide you with 10 different designs. If you are not satisfied with any of them, we can refer you to other designers and you do not pay the final 50%.
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MESSAGE BOARD: $170.00 Setup Fee - We install a customizable message board (PHPBB) that provides a number of popular features that help enhance and build an online community. This includes an administration panel and client training so you can manage your community without us!
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FLASH DESIGN: $85.00/hour - Only specific requests will be taken. Please contact us for more information.
AUDIO: $85.00/hour - We can convert audio from a CD into online media and display using your choice of media players.
VIDEO TRANSFER & EDITING: Transfer your precious memories to CD/DVD & ensure years of enjoyment without degradation or fading! Instead of fast forwarding through miles of boring tape footage (like the times you were recording and didn't know it!), have your home & wedding videos edited to your taste! Music, voice overs...it's all within your reach...and your budget! VHS, Hi8, Digital8 and miniDV. Please contact us for more information.
KMWeb Designs is pleased to offer you a branded, shopping cart solution that is economical, flexible and scalable for any type of business. Please carefully review the information provided below. All fees listed on this page are in addition to any site design that has been quoted.
To sell products on your site, you will need three things: A Shopping Cart so that your customers can choose to add and remove the products they would like to purchase, a Secure Server so that online transactions take place in a secure environment, and a Merchant Account which allows you to accept credit cards and transfer money into your bank account.
$85.00/hour - A database is simply site code that allows powerful functionality for your website. From content management solutions, to user registration accounts and backend administration panels, a database can put site control in your hands and allow for solutions to almost anything you can dream up.
If you are looking for services not listed, let us know. We may provide them or we may be able to recommend you to someone who does.


According to the Centers for Disease Control, global access to safe water, adequate sanitation, and proper hygiene education can reduce illness and death from disease, leading to improved health, poverty reduction, and socio-economic development. However, many countries are challenged to provide these basic necessities to their populations, leaving people at risk for water, sanitation, and hygiene (WASH)-related diseases. Resources available within this theme offer information on providing access to safe water and appropriate sanitation facilities, and introducing sound hygiene behaviors.


إزالة العلامة المائية والحقوق من الصور والفيديو ببساطة وبسرعة مع برنامج Apowersoft Watermark Remover.
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Michelson Medical Research Foundation / Gary K. Michelson / Videos & Interviews | Gary Karlin Michelson, M.D. / SABIN Award 2015: Gary K. Michelson [Video] [2015-03-25]
Gary K. Michelson, Peter J. Hotez, Maria Bottazzi et al.; Humanitarian SABIN Award [MMRF] [2015-03-25]
Press Excerpt
On March 25th 2015, renowned orthopedic spinal surgeon and inventor Dr. Gary K. Michelson is awarded the Albert B. Sabin Humanitarian Award by the SABIN Vaccine Institute in acknowledgement of the significant, continual financial contributions he has made to their research programs including the Michelson Neglected Disease Vaccine Initiative.
Peter J. Hotez: This artist basically talked to all of our scientists and said, "What are the words that come to mind when you think about working here in our unit?" Poverty, community —
Female: Perseverance.
Peter J. Hotez: Perseverance, awareness, compassion.
Maria Bottazzi: That's a great idea.
Gary K. Michelson: This is what we were talking about on the walk over. This is what we need to do. Yeah, it's great.
Michael Marine: Dr. Michelson is exactly the kind of person we want to recognize and honor through the Albert B. Sabin Humanitarian Award. I've had the pleasure of seeing firsthand the game-changing impact that his support has made in bringing NTDs to the consciousness of global decision-makers through the Michelson Fund for NTDs Global Awareness.
We count ourselves very fortunate to have Dr. Michelson by our side in working toward a world free of needless human suffering from vaccine-preventable and neglected tropical diseases. Together we are delivering on the promise of a healthier future for the nearly two billion people still plagues by NTDs and vaccine-preventable diseases. Thank you, Dr. Michelson, for all that you do.
And I'd also like to thank our guests for joining us this evening. Thank you very much.
Axel Hoos: Good evening. I just wanted to take a moment and welcome you for this wonderful event tonight. I'm Axel Hoos. I'm the interim chairman of the SABIN Vaccine Institute, and I'm welcoming you to the awards dinner for the SABIN Humanitarian Award that we are having the opportunity to give to Dr. Gary K. Michelson tonight.
Now one word about the SABIN Humanitarian Award: the award commemorates the work of Albert B. Sabin, who has developed the first vaccine against polio that has helped to almost eradicate polio worldwide, which is a very important contribution to global human health and is a model that we like to look at when we try to do the same for other, um, vaccinatable diseases.
So with having said that, one word about Dr. Michelson. I have met you the very first time today. Besides the financial contributions you have made to SABIN that have enabled us to drive some of our programs forward, I've been very impressed with your intellectual curiosity and your drive to tackle some of the problems we face in a very different way than we conventionally do. And I think there's a lot more we can do together and I'm very pleased that this opportunity exists.
Peter J. Hotez: So Gary represents to me the type of person that I admire most who's a scientist and a physician, but also strives towards humanitarian goals. I often like to quote Dr. Albert Sabin who once said, "A scientist is also a human being, cannot rest while knowledge, which might relieve suffering, rests on the shelf," and that's I think how Gary and I really got introduced.
So he's now receiving, this evening the Albert B. Sabin Humanitarian Award. And, I don't know if Gary knows this, but only two other people have gotten the Albert B. Sabin Humanitarian Award. Are you ready? Richard Holbrook and Paul Simon.
Male 1: I hope you can sing.
Peter J. Hotez: I'm absolutely thrilled you're linked with us, Gary, and, um, I feel very, very honored that, um, you're a part of the SABIN family, the SABIN team at Baylor and Texas Children's Hospital. Yeah, we're just absolutely lucky to have you.
Dr. Michelson is supporting us and advising us — so it's not just support; it's also advice — on how to tackle the most common afflictions of the world's poor.
So if you think about the 1.4 billion people in the world that live on no money, live below the World Bank poverty figure of $1.25 a day, every single of those individuals is infected with the diseases that we study here at SABIN Vaccine Institute.
This economist that we've worked with Hoyt Bleakley, at the University of Chicago has now done an analysis showing that chronic hookworm infection reduces your future wage earning by 40 percent. So the other message of these diseases, which is a little hard to — 'cause a lot of these are not killer diseases.
Gary K. Michelson: If nothing else, they should care about the economic impact. That's what they're all about.
Peter J. Hotez:	Right, right. So these are the diseases that trap the bottom billion in poverty. They're also the ones that trap Americans in poverty too.
Gary K. Michelson: I've actually gone around a good part of the world, and up until two or three years ago when I read Peter's article, I had no idea about this.
So how could that possibly — how could the industrialized world be so ignorant about this? I think we don't see it, because these societies that we live in don't wanna see it.
Peter J. Hotez: What's amazing about what Gary does is he just doesn't go after the high-profile diseases that make the cover of TIME magazine. He's actually getting to the heart of what causes poverty in the developing world.
Maria Bottazzi: This is Maureen Merrifield.
Gary K. Michelson: Hi, how are you?
Maureen Merrifield: Nice to meet you. How are you? Good.
Maria Bottazzi: Maureen is my right-hand side for all the regulatory components when we have to deal with FDA —
Peter J. Hotez: So we have to provide annual reports to the FDA. The FDA will ask us questions, and it's very prescriptive how you do it. You can't just pick up the phone and answer the question. It has to be answered in a certain way and —
Maria Bottazzi: Yeah, there's an etiquette. These machines actually help them really design how to clean that —
Peter J. Hotez: This is the ÄKTA avant system, so this is what Texas Children's bought us, which is great.
These will allow you to look at multiple column resins and separate proteins on the basis of charge or mass, or charge-mass ratio, and do it in a very standardized way so you get the same result each time.
Male 2: So this is our analytical section. We do all our protein characterization down here. We have some new technologies. We have here a CD, circular dichroism, where we look at secondary structures of proteins.
We have down there an HBLC hooked to [inaudible] looking at size of the proteins, but also looking through dynamic light scattering and static light scattering. For example, looking if there are, for example, glycans around the proteins. We also have a —
Peter J. Hotez: So he's really pioneering how to use biophysical methods to analyze your vaccine.
Maria Bottazzi: So we have different scales so we can go from one-liter scale, which — this is a manifold, so the same machine can actually optimize different parameters.
Then we go scale up to five liters, and in the other room I can show you the 10-liter, and then in this one is our master 20-liter. So this is exactly the same scale and fermenter that you would find in a manufacturing facility.
Peter J. Hotez: This is the minimum scale you would need to get enough material to do a Phase I trial.
Gary K. Michelson: People are living on the razor's edge of starvation, and in addition to that, there're being eaten from the inside out by worms who are stealing the little bit of nutrition that they have. It's unconscionable.
Peter J. Hotez: It takes a village to make a vaccine. Out of all the different areas that —
Gary K. Michelson: You're preaching to the preacher.
Maria Bottazzi: Yes, exactly.
Gary K. Michelson: I mean this is exactly what we're talking about for this conference. It doesn't matter that they're not working on vaccines. It's not what we need to be doing. We just need this.
Dr. Gary K. Michelson Receives Albert B. Sabin Humanitarian Award
WASHINGTON, D.C. — March 25, 2015 — The Sabin Vaccine Institute (Sabin) will present the Albert B. Sabin Humanitarian Award to Gary K. Michelson, MD, a distinguished orthopedic spinal surgeon and inventor, in recognition of his extraordinary philanthropy and commitment toward the control and elimination of neglected tropical diseases (NTDs) through high-level advocacy and vaccine research and development. He will be honored today at a private event with Sabin's executive leadership, Board of Trustees and key members of the scientific community in Houston, Texas.
"We are pleased to honor Dr. Gary K. Michelson whose advocacy, research and tremendous generosity has enabled millions of people to live healthier, more productive lives," said Peter J. Hotez, MD, PhD, president of Sabin. "An innovator and entrepreneur, Dr. Michelson's impact on the field of science and technology is undeniable. We also greatly admire his leadership in the advancement of science through philanthropy — a quality that distinguishes him among scientists. This commitment is evident in his work with various foundations and significant investments in cutting-edge medical research."
His inventions, including surgical instruments known as "Michelson devices," are widely acknowledged for making spinal surgery safer, faster, more effective and less expensive. He continues to push for innovative advancements through philanthropic investments in medical research and bioscience that could potentially help some of the world's poorest, most marginalized communities.
"If out of sight is out of mind, then I can think of no area of medicine where so very many people are being adversely impacted that is more in need of being brought to the consciousness of the rest of the world," said Dr. Michelson, in reference to the scourge of NTDs.
Since his retirement from medical practice, Dr. Michelson has fully dedicated himself to philanthropic efforts and founded several charitable organizations that focus primarily on genetic research, an open architecture platform for higher education textbooks, and animal welfare. In addition, the Michelson Medical Research Foundation, which supports forward thinking initiatives in medical science, has made generous investments in the Michelson Fund for NTDs Global Awareness and the Michelson Neglected Disease Vaccine Initiative. These investments have raised awareness and mobilized new resources to increase treatment programs for NTD control and elimination and supported game-changing vaccine research and development initiatives for NTDs, respectively.
The Albert B. Sabin Humanitarian Award recognizes an individual who has made extraordinary contributions to reduce needless human suffering from vaccine-preventable and neglected tropical diseases. The award commemorates the legacy of Dr. Albert B. Sabin, who developed the oral live virus polio vaccine that is widely heralded for contributing to the near eradication of polio worldwide.
Previous recipients include doctors and researchers, such as Franklin H. Top Jr., MD, and Wayne T. Hockmeyer, PhD, as well as philanthropists from the media and entertainment industry, among them Larry King and Paul Simon.
Dr. Gary Michelson Receives Albert B. Sabin Humanitarian Award [2015-03-25. Kelly Toves. Sabin Vaccine Institute]
About the Sabin Vaccine Institute
The Sabin Vaccine Institute (Sabin) is a non-profit, 501(c)(3) organization of scientists, researchers and advocates dedicated to reducing needless human suffering from vaccine-preventable and neglected tropical diseases (NTDs). Since its founding in 1993 in honor of Dr. Albert B. Sabin, the developer of the oral polio vaccine, Sabin has been at the forefront of global efforts to eliminate, prevent and cure infectious and neglected tropical diseases.
Sabin develops new vaccines, advocates for increased use of existing vaccines and promotes expanded access to affordable medical treatments in collaboration with governments, academic institutions, scientists, medical professionals and other non-profit organizations. For more information please visit www.sabin.org.
On March 25th 2015, Dr. Gary K. Michelson was awarded the Albert B. Sabin Humanitarian Award by the SABIN Vaccine Institute. Left: Maria Elena Bottazzi, Center: Gary Karlin Michelson, Right: Peter Hotez. {#0138B} (Credit: Anna Grove)
On March 26th 2015, Dr. Gary K. Michelson was awarded the Albert B. Sabin Humanitarian Award by the SABIN Vaccine Institute. Left: Peter Hotez, Right: Gary Karlin Michelson.
Left: Peter Hotez, Center: Gary Karlin Michelson, Right: Maria Elena Bottazzi.
(Front to Camera) Peter Thoren, Ann Hotez, Peter Hotez, Gary Karlin Michelson & Maria Elena Bottazzi; (Back to Camera) Marc Shapiro, Michael Marine.
Dr. Albert B. Sabin
A scientist is also a human being, cannot rest while knowledge, which might relieve suffering, rests on the shelf.
People are living on the razor's edge of starvation, and in addition to that, there're being eaten from the inside out by worms who are stealing the little bit of nutrition that they have. It's unconscionable.
Michael Marine
We count ourselves very fortunate to have Dr. Michelson by our side in working toward a world free of needless human suffering from vaccine-preventable and neglected tropical diseases.
Peter J. Hotez
What's amazing about what Gary does is he just doesn't go after the high-profile diseases that make the cover of TIME magazine. He's actually getting to the heart of what causes poverty in the developing world.
Vimeo [2015] Gary K. Michelson; SABIN Humanitarian Award 2015 [MMRF] [2015-03-25]
Beneficiary Initiative Library
SABIN Vaccine Institute Michelson Neglected Disease Vaccine Initiative [Sabin] Neglected Tropical Diseases Archives


Hugh Jackman and Russell Crowe both had a rocky start in the roles. Jackman did a much better job as Valjean as soon as he was allowed to shave -- he plays 'kind soul with a dark past' better than 'haggard vagrant crushed by the injustice of the world'. Russell Crowe did not grow so well into the role. Still, he was only distractingly bad near the beginning -- I got used to it.
I won't say any more, lest I spoil, except to point out that I cried, a lot. If your heart has turned to stone and you need a film to reach inside you and move something, go see Les Miserables.


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About DGS
Studying at SEU
Welcome to the Deanship of Graduate Studies at Saudi Electronic University. We are looking to play a leading role in the development of postgraduate studies in Saudi Arabia by employing advanced techniques and computing applications which will enhance active learning and scientific research at the postgraduate level. These skills involve networking and gathering information to help build a knowledge-based society.
The Deanship of Graduate Studies is pleased to offer full assistance and support to students in all areas of study and research. Also, we are committed to cooperating with other deanships and colleges to raise the level of the university and achieve its strategic plans to ensure that the Saudi Electronic University becomes a leader in providing postgraduate programs, attracting outstanding students, and contributing towards qualitative research.
The Deanship is also aiming at establishing scientific and practical partnerships with various institutions to improve societal needs and achieve the country's developmental goals.
Why our programs?
All graduate programs are offered in English with partnership of an international leading university Colorado State University- Global Campus, following the latest model of eLearing.
The students received at the completion of the graduate program a certificate from both SEU and Colorado State University- Global Campus.
Our programs are accredited by ABET - ACBSP - CAHME
The Electronic University signs a memorandum of understanding with the Center for Information and Studies
12 ربيع آخر 1441
Tweets by Arabic Online


Merchco's carpentry crews are skilled at installing a variety of finished millwork products and interior trim work with precision and attention to detail. Our teams know that quality and appearance are paramount to our customer's satisfaction and go to great lengths to ensure the job is done right. We are well experienced in the installation of cashwraps, countertops, wall display cabinets, showcases and wood display systems as well as installation of trim work such as dressing rooms, cornice, and moldings and casework. Merchco can provide both union and non-union crews.


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About NVERS
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Regional Trainings
NVERS and NVHA Announce Merger
On April 30, 2021, the Northern Virginia Emergency Response System (NVERS) and Northern Virginia Hospital Alliance (NVHA) announced exciting news about the future of the two organizations. Thanks to the commitment and efforts of many regional partners, the two organizations have successfully coordinated, supported, and promoted a regional approach to preparedness, response, and recovery activities for the past two decades.
The hospitals and localities of Northern Virginia believe region-wide systems and capabilities, spanning both jurisdictional and discipline boundaries, are essential to a collective and coordinated response to emergencies and disasters to provide the highest level of care to our community. In that spirit, NVHA and NVERS are pleased to announce the planned merger of the two organizations. The merger will remove an organizational boundary to allow for enhanced collaboration among our expanding coalition of community partners.
When the leadership of the 16 member hospitals formed NVHA in 2002 in the wake of 9/11, they did so recognizing that while the hospitals are daily competitors, it was imperative to operate as a unified healthcare system during disasters and emergencies. In doing so, NVHA formed the nation's first healthcare coalition and became the catalyst for others and federal support for similar efforts throughout the nation. Today there are more than 470 federally recognized and funded healthcare coalitions.
NVERS charted a similar path. Although it was created in 2005 as a regional Metropolitan Medical Response System, the partners quickly recognized an opportunity for broader emergency response collaboration. They rebranded as NVERS in 2007 to reflect that multi-disciplinary focus. Today, nine disciplines representing twenty-five localities build and enhance Northern Virginia's capability and capacity and serve as a national model for a regional approach to preparedness.
Over the course of the past two decades, both organizations and the region we serve have evolved. Our stakeholders and their needs have expanded and begun to overlap, either through necessity or due to funding requirements, as community preparedness now involves a multitude of partners and capabilities. That has blurred our organizational boundaries.
While natural synergies exist between NVHA and NVERS, not least of which being our shared missions for coordinating preparedness and response among our respective members, a boundary has nonetheless persisted due to the restrictions of our separate federal funding streams. Merging these two regional organizations will remove such restrictions. It also will reduce competing or redundant activities, allowing us to focus more on meeting the expanding needs of our coalition partners, and clear any confusion about our sometimes overlapping roles. For example, it is NVHA that operates the Regional Healthcare Coordination Center that interacts regularly with the response agency membership of NVERS.
The interdependence of our two organizations, and the value of a more seamless relationship, has been highlighted during the region's ongoing response to COVID-19, through which we have supported our partners every step of the way from procurement of PPE to testing to vaccination. This merger will provide even greater opportunities for stakeholders to further their efforts with strategic planning, priority setting, information sharing, training, exercises, and equipment acquisition.
Participation from stakeholders will continue as before, albeit soon with the combined resources, expertise, and support from a combined organization. A formal name change will be forthcoming. Our member hospitals and localities are excited to begin this transition, and we are grateful to all of our partners for their continued time and dedication to the communities we serve. We look forward to sharing additional updates as we undertake this next chapter in regional preparedness and response in Northern Virginia.
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This website was prepared under a grant from the Federal Emergency Management Agency's Grant Programs Directorate (FEMA/GPD) within the U.S. Department of Homeland Security. Points of view or opinions expressed in this document are those of the authors and do not necessarily represent the official position or policies of FEMA/GPD or the U.S. Department of Homeland Security.
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A Singapore Government Agency Website How to identify
Official website links end with .gov.sg
Government agencies communicate via .gov.sg websites (e.g. go.gov.sg/open). Trusted websites
Secure websites use HTTPS
Look for a lock ( ) or https:// as an added precaution. Share sensitive information only on official, secure websites.
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A PLACE TO GO: HEROIC AND POWERFUL...
A PLACE TO GO: Heroic and Powerful – Jurong Town Hall
Tan Kok Hiang, principal director of Forum Architects, lets us in on what it takes to restore Jurong Town Hall, an icon of modern architecture.
Jurong Town Hall was very heroic and powerful. It had something to say," says Tan. In 2017, his firm, Forum Architects, completed a detailed restoration of the iconic Jurong Town Hall, which has become a significant landmark and symbol of Singapore's successful industrialisation efforts.
Completed in 1974, Jurong Town Hall served as the headquarters of Jurong Town Corporation (currently known as JTC Corporation) formed in 1968 to spearhead industrial growth. A site was chosen atop an 80-foot-long hill commanding sweeping views of the area and a design competition was held in 1969. The winner, selected from 34 entries, was Architects Team 3 led by pioneer architect Datuk Seri Lim Chong Keat, who designed many significant buildings in the 1960s and 1970s including the Singapore Conference Hall.
The building's sense of gravitas comes from its brutalist design, an extension of modern architecture known for massive, unadorned and unpretentious structures built from raw concrete. Lim Chong Keat also added nautical design elements – from the outside, the cantilevered upper storeys gave the building the appearance of a ship's hull and the tall clock tower, a mast.
Jurong Town Hall is a product of an exceptional period in our history, and its architecture captures the spirit of an era when our pioneer generation was boldly imagining and developing the future of Singapore," says Ng Lang, CEO of JTC Corporation (2017 to 2020). "Even today, it stands as an innovative landmark embodying what the JTC spirit stands for."
In 2000, JTC moved to the JTC Summit, and the building was renamed iHub in 2004 to attract start-up technology companies who needed affordable office space. Upper levels were subdivided into many units until 2005, when Jurong Town Hall was gazetted first as a conserved building before it was designated as a national monument in 2015. Since 2017, it is a hub for trade associations.
To peel back the layers of history, Tan and his team found information and inspiration from a surprising source: old copies of the Singapore Institute of Architects Journal which had detailed coverage of the competition and original photos. He also met a long-time JTC employee, who regaled the team with stories about the old building. The result is a masterpiece that continues to reflect the spirit and essence of the building.
The grand entrance
Visitors to Jurong Town Hall enter an airy square concourse atrium, the building's focal point. From high above, natural sunlight streams through a glass ceiling, illuminating glossy white stucco walls and marble floors buffed to a mirror finish. Surprisingly, the marble is original, says Tan, a testament to using quality building materials.
Overhead, the upper floors appear stacked in cantilevered tiers, creating a visual effect that emphasises horizontal lines, which Tan explains is typical of the original architect's design aesthetic. Tan referenced this aesthetic when he created the thin horizontal brass strip that runs along all four walls of the concourse, level with the lintels of the door openings.
In the centre of the concourse, a massive cantilevered white concrete and marble staircase leads to the basement. Special waiver was sought to preserve it, as the height of the handrails would not meet current building code.
Illuminating the void
At the far end of the concourse, 2 walls in original white ceramic tile slope down through narrow voids to the basement below. The voids, likely added for air and light circulation, had been sealed over during previous renovations, but Tan reopened the space and installed sculptural light installations above them. Tidy rows of wires dangling naked bulbs at various lengths, some continuing straight through to the basement, draw the eye to the spaces without overpowering them.
Retro 70s events
The ceiling in the main auditorium was of interest, with curious 70s-style curved details that Tan describes as almost marine in appearance. To update the acoustics of the great hall, he chose a wall treatment that referenced the original dark wood walls that flank the stage, creating a herringbone-like texture of wooden planks. A wainscot in matching dark wood covers the lower portion of the walls, providing a further design connection between the stage and hall.
Functional spaces
Over the years, every square foot of usable space was sectioned off for office rentals. Glass windows that overlooked the atrium lobby were boarded up. A recessed terrace with stunning views was closed off. Now, the spaces have been stripped back to their original bones and the upper levels reveal airy open spaces and wide corridors illuminated by natural light that streams in through restored windows.
Design motifs
In updating spaces for contemporary use, such as breakout rooms and meeting spaces, Tan retained the spirit of the building through décor motifs. Hexagons are instantly noticeable, adorning walls, carpets and glass panels. "If you look at the outside of the building," he says, "you'll see that it's actually shaped like two elongated hexagons, so we replicated that."
These spaces are also where he has introduced color: brass, chrome, shades of lime, orange and other earthy tones that provide subtle winks to the building's 70s roots. The maritime theme is continued in the rounded corner detail, or 'fillet', of the internal doorways, a style that was popular in the 1970s.
More on Jurong Town Hall
Jurong Town Hall is among the 7 national monuments built after World War II. According to the National Heritage Board, the building was gazetted as a monument because of its national significance, being built during Singapore's early years of industrialisation and was the work of a pioneering group of local architects.
The building is also part of Singapore's modern architecture that reflect the gradual awakenings and aspirations of nation-building after 1945. Through careful balancing of land use needs and in consultation with the Conservation Advisory Panel and other stakeholders and communities, a significant number of modern buildings have been protected over the years. These were presented in URA's exhibition, 'Heritage of our modern past' to celebrate their value and importance to Singapore's built heritage. The exhibition was on display at the Singapore Heritage Festival in 2017 and 2018.
By Jennifer Eveland
Photography by Darren Soh
This article was first published in Skyline issue 9.
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(mort avant 1231) fut vicomte de Léon, succédant à son père .

Biographie

 (dit "le Bref"), décédé avant 1231, fut capturé, ainsi que le  duc de Bretagne  en 1202 alors qu'ils assiégeaient Mirebeau où était réfugiée Aliénor d'Aquitaine, grand-mère d', contre son fils Jean sans Terre dans la revendication du trône d'Angleterre laissé vacant par le décès de Richard Cœur de Lion en 1199. Emprisonné au château de Chinon, il est libéré en  par les troupes de Philippe Auguste.

Conan tuteur de son neveu le jeune Henri d'Avaugour tente ensuite de défendre les droits de ce dernier contre la spoliation du nouveau duc Pierre Mauclerc. Entre 1214 et 1216, le Léon est envahi par Pierre de Dreux, dit Mauclerc, qui conquiert Lesneven en 1216. La rébellion menée par de nombreux nobles bretons et à laquelle participe Conan le Bref, est matée lors de la bataille de Châteaubriant en 1222, et ces nobles doivent accepter Pierre Mauclerc, époux d'Alix de Thouars, héritière du duché, comme nouveau duc de Bretagne.

Union et postérité
 a épousé, vers 1195, Alix de Penthièvre, fille d'.

Son fils  lui succède comme vicomte de Léon.

Notes et références

Bibliographie
 Patrick Kernévez, André-Yves Bourgès Généalogie des vicomtes de Léon (,  et s). Bulletin de la Société archéologique du Finistère, t. , 2007, 157-188.

Vicomte de Léon
Famille de Léon

redpajama_set_name: RedPajamaWikipedia


I wanted to thank you Gary Cope for resolving the issue regarding the missing pages from the GP records. I know it was causing issues from your side and it could have resulted in us having a problem when trying to comply with the Courts directs. You resolved it immediately, which I thank you for.


While you can't force someone to seek treatment for BPD, but you can take steps to improve communication, set healthy boundaries, and stabilize the relationship. What you need to know about BPD People with borderline personality disorder (BPD) tend to have major difficulties with relationships, especially with those closest to them.... The danger of using the familiar form when you should not, is that you may come across as insulting or condescending to the person you are speaking to, even if you do not intend to. In general, you should use the formal forms of "you" unless there is a reason to use the familiar form. That way, you are safely coming across as polite rather than risking being rude.
Support The Guardian 'Don'ts' aren't helping: here's five things you can say to someone with a disability Robert Hoge . When it comes time to talk about living with a disability, many of us... A reason why would someone would not be in the mood to talk is simply they are under the optimal mood and that is contentment, something is bothering them or they are busy with something else more important then your desire to chat with someone.
If the person doesn't respond or you become aware that he or she has a hearing problem, you can increase your volume. Speaking in a slightly lower register can also help if someone …... 10/12/2006 · CharlieDIY wrote: BobTrips wrote: It's useful to the extent that it lets one shoot from camera positions other than camera-to-eye. But it's just a work-around to a system that needs to be replaced.
If someone is describing their complicated job to you or a profession you're not familiar with they may be well aware of your lack of knowledge. By repeating what they say or asking for clarification, you're creating a sense of interest and rapport.
The danger of using the familiar form when you should not, is that you may come across as insulting or condescending to the person you are speaking to, even if you do not intend to. In general, you should use the formal forms of "you" unless there is a reason to use the familiar form. That way, you are safely coming across as polite rather than risking being rude.
Remember, both of you aren't dating yet, and you have no right to tell this person who they can or can't talk to. If you show off your displeasure to your crush, they'd only get more annoyed with your behavior. Just pretend like it doesn't bother you.
When you spend a lot of your mental energy focusing on a celebrity, they can often make an appearance in your dream as someone you are very familiar with. Unfortunately, dreaming about a celebrity does not mean you are going to start dating your celebrity crush.
You might talk about religious or cultural traditions around death that are important in the person's faith or culture. In films, use depictions of death as an opportunity to talk about the permanence of death.


Company Profile - Hughes Transport Ltd.
First established in 1979 by Stuart Hughes with one truck transporting products around Auckland.
Over the years Stuart mainly operated as a local company until deregulation of the industry enabled him to transport further a field.
In 2008 Bryn & Sue Smith purchased the business from Stuart, and have continued to evolve into one of New Zealand's up and coming freight companies, with it's emphasis on "service first" and specialist food freight NZ-wide. Our commitment to our customers is to ensure efficient, reliable and trouble free management of your freight requirements - by providing the very best service along with the very best rates.
Hughes has built a reputation and business success on delivering on the commitments we've made to our customers - and by proving that we do truly care.


Classic black and silver with brass rivoting Weighs only 80 gram (2.8 oz ).
Classic black and silver flipknife with brass rivoting. Good choice for a working knife.
A very fuctional cutting tool with a super comfortable handle, made from Zytel which is a material widely used for tool handles, it is very strong, light and shockproof.
Satin finished High Carbon Sheffield Steel is an excellent steel used in many cutting tools.
Drop point hollow ground blade hardened to Rockwell 58, which is as hard as possible and still retain blade flexabilty. This steel blade will discolour and patina with use - just like a regular saw blade or chisel. Side bolsters ,locking leg and knife fittings are made from stainless Sheffield steel.


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text:
namespace extensions {

class InputImeApiTest : public ExtensionApiTest {
 public:
  InputImeApiTest() {}

 protected:
  // Sets the private flag of |track_key_events_for_testing_| in InputMethod.
  void SetTrackKeyEvents(ui::InputMethod* input_method, bool track) {
    input_method->track_key_events_for_testing_ = track;
  }

  // Returns true if the key events get from input method equals to the expected
  // key events.
  bool CompareKeyEvents(
      const std::vector<std::unique_ptr<ui::KeyEvent>>& expected_key_events,
      ui::InputMethod* input_method) {
    if (expected_key_events.size() != GetKeyEvents(input_method).size())
      return false;
    for (size_t i = 0; i < expected_key_events.size(); i++) {
      ui::KeyEvent* event1 = expected_key_events[i].get();
      ui::KeyEvent* event2 = GetKeyEvents(input_method)[i].get();
      if (event1->type() != event2->type() ||
          event1->key_code() != event2->key_code() ||
          event1->flags() != event2->flags()) {
        return false;
      }
    }
    return true;
  }

 private:
  // Returns the tracked key events of using input.ime.sendKeyEvents API.
  const std::vector<std::unique_ptr<ui::KeyEvent>>& GetKeyEvents(
      ui::InputMethod* input_method) {
    return input_method->GetKeyEventsForTesting();
  }

  DISALLOW_COPY_AND_ASSIGN(InputImeApiTest);
};

// TODO(crbug.com/882338) This test fails basically once per try run.
// See bug for details.
IN_PROC_BROWSER_TEST_F(InputImeApiTest, DISABLED_BasicApiTest) {
  // Manipulates the focused text input client because the follow cursor
  // window requires the text input focus.
  ui::InputMethod* input_method =
      browser()->window()->GetNativeWindow()->GetHost()->GetInputMethod();
  std::unique_ptr<ui::DummyTextInputClient> client(
      new ui::DummyTextInputClient(ui::TEXT_INPUT_TYPE_TEXT));
  input_method->SetFocusedTextInputClient(client.get());
  ExtensionFunction::ScopedUserGestureForTests scoped_user_gesture;
  base::AutoReset<bool> auto_reset_disable_bubble(
      &InputImeActivateFunction::disable_bubble_for_testing_, true);
  SetTrackKeyEvents(input_method, true);

  // Listens for the input.ime.onBlur event.
  ExtensionTestMessageListener blur_listener("get_blur_event", false);

  ASSERT_TRUE(RunExtensionTest("input_ime_nonchromeos")) << message_;

  // Test the input.ime.commitText API.
  const std::vector<base::string16>& insert_text_history =
      client->insert_text_history();
  ASSERT_EQ(1UL, insert_text_history.size());
  EXPECT_EQ(base::UTF8ToUTF16("test_commit_text"), insert_text_history[0]);

  // Test the input.ime.setComposition API.
  ui::CompositionText composition;
  composition.text = base::UTF8ToUTF16("test_set_composition");
  composition.ime_text_spans.push_back(ui::ImeTextSpan(
      ui::ImeTextSpan::Type::kComposition, 0, composition.text.length(),
      ui::ImeTextSpan::Thickness::kThin,
      ui::ImeTextSpan::UnderlineStyle::kSolid, SK_ColorTRANSPARENT));
  composition.selection = gfx::Range(2, 2);
  const std::vector<ui::CompositionText>& composition_history =
      client->composition_history();
  ASSERT_EQ(2UL, composition_history.size());
  EXPECT_EQ(base::UTF8ToUTF16("test_set_composition"),
            composition_history[0].text);
  EXPECT_EQ(base::UTF8ToUTF16(""), composition_history[1].text);

  // Tests input.ime.onBlur API should get event when focusing to another
  // text input client.
  std::unique_ptr<ui::DummyTextInputClient> client2(
      new ui::DummyTextInputClient(ui::TEXT_INPUT_TYPE_TEXT));
  input_method->SetFocusedTextInputClient(client2.get());
  ASSERT_TRUE(blur_listener.WaitUntilSatisfied()) << message_;

  input_method->DetachTextInputClient(client2.get());
}

// The following test verifies that key events do not get sent on any page.
// This is in preparation of deprecating the sendKeyEvents API.
// TODO(crbug.com/1004628) Flakes on Windows and Linux
#if defined(OS_WIN) || defined(OS_LINUX)
#define MAYBE_SendKeyEventsOnNormalPage DISABLED_SendKeyEventsOnNormalPage
#else
#define MAYBE_SendKeyEventsOnNormalPage SendKeyEventsOnNormalPage
#endif
IN_PROC_BROWSER_TEST_F(InputImeApiTest, MAYBE_SendKeyEventsOnNormalPage) {
  // Navigates to special page that sendKeyEvents API has limition with.
  ui_test_utils::NavigateToURL(browser(), GURL(chrome::kChromeUINewTabURL));
  // Manipulates the focused text input client because the follow cursor
  // window requires the text input focus.
  ui::InputMethod* input_method =
      browser()->window()->GetNativeWindow()->GetHost()->GetInputMethod();
  std::unique_ptr<ui::DummyTextInputClient> client(
      new ui::DummyTextInputClient(ui::TEXT_INPUT_TYPE_TEXT));
  input_method->SetFocusedTextInputClient(client.get());
  ExtensionFunction::ScopedUserGestureForTests scoped_user_gesture;
  base::AutoReset<bool> auto_reset_disable_bubble(
      &InputImeActivateFunction::disable_bubble_for_testing_, true);
  SetTrackKeyEvents(input_method, true);

  ASSERT_TRUE(RunExtensionTest("input_ime_nonchromeos")) << message_;

  std::vector<std::unique_ptr<ui::KeyEvent>> key_events;

  EXPECT_TRUE(CompareKeyEvents(key_events, input_method));

  input_method->DetachTextInputClient(client.get());
}

// The following test verifies that key events do not get sent on any page.
// This is in preparation of deprecating the sendKeyEvents API.
// TODO(https://crbug.com/795631): This test is failing on the Linux bot.
// TODO(https://crbug.com/795631): This testis failing on Windows bot.
#if defined(OS_WIN) || defined(OS_LINUX)
IN_PROC_BROWSER_TEST_F(InputImeApiTest, DISABLED_SendKeyEventsOnSpecialPage) {
#else
IN_PROC_BROWSER_TEST_F(InputImeApiTest, SendKeyEventsOnSpecialPage) {
#endif
  // Navigates to special page that sendKeyEvents API has limition with.
  ui_test_utils::NavigateToURL(browser(), GURL("chrome://flags"));

  ui::InputMethod* input_method =
      browser()->window()->GetNativeWindow()->GetHost()->GetInputMethod();
  std::unique_ptr<ui::DummyTextInputClient> client(
      new ui::DummyTextInputClient(ui::TEXT_INPUT_TYPE_TEXT));
  input_method->SetFocusedTextInputClient(client.get());
  ExtensionFunction::ScopedUserGestureForTests scoped_user_gesture;
  base::AutoReset<bool> auto_reset_disable_bubble(
      &InputImeActivateFunction::disable_bubble_for_testing_, true);
  SetTrackKeyEvents(input_method, true);

  ASSERT_TRUE(RunExtensionTest("input_ime_nonchromeos")) << message_;

  std::vector<std::unique_ptr<ui::KeyEvent>> key_events;

  EXPECT_TRUE(CompareKeyEvents(key_events, input_method));
  input_method->DetachTextInputClient(client.get());
}

}  // namespace extensions

redpajama_set_name: RedPajamaGithub


text:
International Science Council (ISC) – Paris, France
Date added: October 5, 2018 Application deadline: October 28, 2018 Contract type: permanent Hours: full-time Salary: Dependent on experience and qualifications
The International Science Council (ISC) is a non-governmental organisation with a unique global membership that brings together 40 international scientific Unions and Associations and over 140 national and regional scientific organisations, including Academies and Research Councils.
The mission of the ISC is to act as the global voice for science. Its activities focus on three principle areas of work:
Science-for-policy
Policy-for-science
Scientific freedom and responsibility
The International Science Council (ISC) is seeking a Senior Communications Officer to join its Communications team on a permanent contract and starting as soon as possible.
Reporting to the Science Director, you will take the lead in developing the ISC communications and outreach strategy, in line with the ISC vision and mission.
You will be responsible for managing the development and implementation of communication activities in support of that strategy, including membership engagement, press/media relations and all types of content: print, audio-visual and digital (website, blogs, social media, etc).
You will also manage the use and promotion of the ISC brand.
You will work alongside colleagues on a wide range of ISC projects, activities and events, as well as representing the Council in meetings and conferences.
You will participate in relevant Management Working Groups and take responsibility for the management of one of ISC's Advisory Bodies, working on issues of outreach and engagement.
This role involves working closely with the other members of the communications team at ISC (total of 3 staff) and interacting with project teams across the organisation's Paris headquarters (23 staff in 2018) and with broader networks of ISC Members, Governance Bodies, stakeholders and partners.
This is an exciting opportunity to join a brand-new organisation that has recently been launched, following the merger of two prestigious membership bodies representing the natural and the social sciences – the International Council for Science (ICSU) and the International Social Science Council (ISSC).
ISC is seeking enthusiastic candidates who have a keen interest in issues around the intersection between policy, science and society and with the following:
Qualifications and knowledge
Master's degree or higher in a relevant discipline
At least 10 years' experience in communications and outreach, in an international environment
Knowledge and experience of the key actors and networks comprising the international scientific landscape
Excellent track record in media relations and in public relations
Experience in developing communications activities in support of member engagement
Experience and knowledge of website management and social media tools
Experience of events communications and of developing campaigns
Excellent knowledge of English; knowledge of French would be an advantage
Excellent interpersonal and networking skills and ability to work in an international and multicultural context
Capacity to work cooperatively in a project mode and to contribute across different teams
Excellent writing and storytelling skills; able to produce communications content rapidly and efficiently
Applicants should either be EU nationals or should hold a valid French work permit.
Applications (preferably in one combined PDF file) should include a CV, cover letter and the contact details of three referees and should be sent to [email protected] with "Senior Communications Officer" in the subject line.


text:
Laura Ingle is a correspondent for Fox News.

Joining the network in 2005, Ingle was originally based in Dallas, and is currently based in New York.  She has also appeared on the FNC program Geraldo Rivera Reports.

Prior to being hired by Fox News, Ingle reported on the Scott Peterson and Michael Jackson trials for talk radio station KFI AM 640 in Los Angeles, and served as a news anchor/reporter for KFBK in Sacramento.  At KFBK, Ingle worked with a number of current Fox News personalities, including Fox Business anchor/host and Fox News Radio host Tom Sullivan, and Fox News Radio host Spencer Hughes.

Personal life
Ingle is married to Kenny Kramme. In 2013, she gave birth to their son, Jackson Marshall Kramme.

References

External links
 Bio on FoxNews.com

Year of birth missing (living people)
American television journalists
American women television journalists
Living people
Fox News people
21st-century American women


text:
Marlene Lee is a 49-year-old Blogger from New Zealand. He was born on Tuesday, August 21, 1973. Is Marlene Lee married or single, and who is he dating now? Let's find out!
As of 2023, Marlene Lee is possibly single.
Her first Instagram post was on June 9, 2013, and was a photo of a note her daughter had written her.
Marlene Lee
August 21, 1973 (age 49)
Fun Fact: On the day of Marlene Lee's birth, "Brother Louie" by Stories was the number 1 song on The Billboard Hot 100 and Richard Nixon (Republican) was the U.S. President.
Marlene Lee's Girlfriend
Marlene Lee is single. He is not dating anyone currently. Marlene had at least 1 relationship in the past. Marlene Lee has not been previously engaged. She has one daughter. According to our records, he has no children.
Like many celebrities and famous people, Marlene keeps his personal and love life private. Check back often as we will continue to update this page with new relationship details. Let's take a look at Marlene Lee past relationships, ex-girlfriends and previous hookups.
Marlene Lee's birth sign is Leo. Leos love being coddled and having their egos stroked. Leos are attracted to someone who's just as vibrant and unique as they are. The most compatible signs with Leo are generally considered to be Aries, Gemini, Libra, and Sagittarius. The least compatible signs with Leo are generally considered to be Taurus and Scorpio. Marlene Lee also has a ruling planet of Sun.
Marlene Lee Biography
Marlene Lee was born on the 21st of August in 1973 (Generation X). Generation X, known as the "sandwich" generation, was born between 1965 and 1980. They are lodged in between the two big well-known generations, the Baby Boomers and the Millennials. Unlike the Baby Boomer generation, Generation X is focused more on work-life balance rather than following the straight-and-narrow path of Corporate America.
Marlene's life path number is 4.
Marlene Lee is best known for being a Blogger. Blogger and freelance photographer based outside of London. She runs the blog Cookies & Candies, which covers lifestyle topics such as fashion, travel and beauty. She has interviewed figures such as Carin Olsson and Alice Gao for her blog. The education details are not available at this time. Please check back soon for updates.
Marlene Lee is turning 50 in
Marlene was born in the 1970s. The 1970s were an era of economic struggle, cultural change, and technological innovation. The Seventies saw many women's rights, gay rights, and environmental movements.
The 49-year-old American was born in the Year of the Ox and is part of Generation X
According to Chinese Zodiac, Marlene was born in the Year of the Ox. People born in the Year of the Ox are persistent and straightforward. They have a strong faith and can be seen as stubborn in their old ways.
Marlene Lee Facts
What is Marlene Lee marital status?
Is Marlene Lee gay?
Marlene Lee has no children.
Is Marlene Lee having any relationship affair?
Was Marlene Lee ever been engaged?
Marlene Lee has not been previously engaged.
How rich is Marlene Lee?
Discover the net worth of Marlene Lee on CelebsMoney
Marlene Lee's birth sign is Leo and he has a ruling planet of Sun.
– View Marlene Lee height, weight & body stats
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Just because the end of the summer is upon us, it is no excuse to put the suncreen away. It's a fact that you need to wear sunscreen each and everyday of the year. You need to reapply your sunscreen if you are spending a lot of time outdoors, doing any kind of activity outside where sunscreen could be wearing off or if you are in the water, of course. I normally have a pretty regular rotation of sunscreen bit this year was different as a few new sunscreen launched over the summer and these new sunscreens are so innovative that they are not only offering sun protection, but they are doing so in such a way to make them stand out from the norm. These are my sunscreen saviors.
This everyday sunscreen is so silky soft and lightweight and perfect for everyday use before putting on makeup. It literally glides on and feels like nothing on the skin except that it tightens the skin and blurs it so it acts as a wonderful pore filler and primer. It was formulated with green tea and rice extract amongst other ingredients that make this a really luxurious sunscreen that I am using as my last step in my skin care routine.
I love this sunscreen for when I am outdoors at the beach or pool. It actually contains a highly advanced Smart Tone technology that matches any skin tone so after it is applied, it matches your skin and gives a little bit of color to the skin so it evens out the skin. I like it because I'm not one to wear a full face of makeup to the beach and this offers a nice amount of protection and evens out my skin so I can slap on some mascara and lip balm with SPF and be good to go. This is also formulated with a 12-hour time release antioxidant complex that helps to guard against photo-damage in the long run and we all could use that.
For my body, I have been depending on this new sunscreen from Moroccanoil. It's not only perfect for offering high sunscreen protection (it comes in SPF 30 as well), it is formulated with nourishing ingredients to hydrate my skin while wearing. Argan oil is antioxidant rich so my skin reaps the benefits plus Vitamin E helps lock in moisture. I really like that this one is super lightweight and melts into my skin as soon as I smooth it on.
When I'm at the beach or pool, I have been using this dry oil. It is also enriched with Argan oil so my skin is nourished while wearing, but this one leaves skin with a bit of a sheen while offering broad spectrum UVA/UVB protection. This dry oil is not greasy and my skin is loving it.


text:
Q: Updating to the database in php I am trying to get the code to update some data that has been selected by the user.
What is happening is that its updating everything in that column to the value the user has edited it to.
For example i have bob, bob1, bob2 and i want to select bob1 to edit. I then edit it so bob1 is now fred1, when it updates it updates every value to fred1. So there is 3 fred1's.
Could someone help? please.
update.php
<?php
session_start();
include_once 'connection.php';

if (isset($_POST['update'])) {
    $success = updateValue($_POST['name']);

    if (!$success)
        echo 'Sorry, the update failed';
    session_destroy();
}
?>
<!DOCTYPE html>

    <meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
    <title>Main Page</title>

    <form action="<?php echo $_SERVER['PHP_SELF']; ?>" method='post'>
        View a Member's Details:
        <select name='members' value='members'id="Mmembers">
            <?php
            $results = getResults('members');
            if ($results) {
                foreach ($results as $row) {
                    echo '<option value="' . $row['member_id'] . '">' . $row['name'] . '</option>';
                }
            }
            else
                echo '<option value="0"0"> No Data</option>';
            ?>

        </select>

        <input type="submit" id="submit" value="Submit"/>

    </form>

    <?php
    if (isset($_POST['members'])) {

        $ResultSet = getMemberResults(($_POST['members']));
        echo "
 Member Details.
";
        echo "
";
        echo "
 Id	 Name	";

        foreach ($ResultSet as $row) {
            echo "<form action=update.php method=POST>";
            echo "
";
            echo "" . "<input type=text name=member_id value=" . $row ['member_id'] . " 	";
            echo "" . "<input type=text name=name value=" . $row ['name'] . "     	";
            echo "" . "<input type=submit name=update value=update" . " 	";
            echo "
";
            echo "</form>";
        }
        echo "
";
    }
    ?>

connection.php
<?php

//Connect to the database
function getSQLConnection() {
    $mysqlConnection = new PDO('mysql:host=localhost;dbname=', "root", "");

    return $mysqlConnection;
}

//Get all results from members table
function getResults($tablename) {
    $sql = "SELECT * FROM " . $tablename;

    $mysqlConnection = getSQLConnection();

    $ResultSet = $mysqlConnection->query($sql);
    return $ResultSet;
}

function getMemberResults($id) {
    $sql = "SELECT * FROM members WHERE members.member_id = '$id'";

    $mysqlConnection = getSQLConnection();

    $ResultSet = $mysqlConnection->query($sql);
    return $ResultSet;
}

function updateValue($id) {
    $sql = "UPDATE members SET name='$id' WHERE members.member_id = members.member_id";

    $mysqlConnection = getSQLConnection();

    $ResultSetting = $mysqlConnection->query($sql);
    return $ResultSetting;
}

?>

A: Your SQL UPDATE statement is incorrect.
WHERE members.member_id = members.member_id

The above where is always going to resolve true for all rows, making your call
UPDATE members SET name='$id'

You should set the name and also add the members id (a unique identity) in the WHERE cause.
/** give functions descriptive names **/
function updateMemberName($id, $name) {
  $sql = "UPDATE members SET name='$name' WHERE id = '$id'";
  //...

update.php
You would then just need to modify the function call
if (isset($_POST['update'])) {
    $success = updateMemberName($_POST['member_id'], $_POST['name']);

A: function updateValue($id) {
$sql = "UPDATE members SET name='$id' WHERE members.member_id = members.member_id";

This is equivalent to
UPDATE members SET name='$id'

as the where clause evaluates to TRUE for all rows

A: Answering only to make it work like you expect it to, This function:
function updateValue($id) {
$sql = "UPDATE members SET name='$id' WHERE members.member_id = members.member_id";
...
}

Needs to be
function updateValue($id, $value) {
$sql = "UPDATE members SET name='$value' WHERE members.member_id=$id";
...
}

redpajama_set_name: RedPajamaStackExchange