The reason for my request is that I am looking for good place where I can order SSD VPS hosting solution and this company seems to be good for me. What do you think about serveyoursite.com? As I see their plans are attractive. Do you know anything about them?
I'd recommend you to use VPS deals from time-tested companies like a2hosting.com and winnervps.com.
VPS hosting from them brings the power and features of a dedicated server at a much lower price point. All of their VPS hosting plans include full root access, allowing you to customize the VPS to your specific needs.
Try to check kvchosting.com ssd vps hosting solutions. The code SSDVPS gives 50% off the price.
I am very pleased working with my site using 4Goodhosting.com. In my personal experience they are exceptional host! Their pricing is reasonable compare to the expensive host I have used before. Their servers is 3x more fast and there are no downtime. The most lovely part is the 24 hours support team. They respond immediately when needed. My support email is responded often with full solution. They never respond in hours. It only takes few minutes. Try them!
To know more about hosts reliability you should look for customer reviews on their services. According to my knowledge serveyoursite.com is delivering top hosting services and stable network. Their servers are solid and support is responsive.
No doubt, SolVPS.com is extremely reliable and the sites go up fast and stay up. The email customer support is fantastic even when the problems are self-created. I've tried other services that looked cheaper on the outside but have always come back to these guys. They offer really good ssd vps deals.
According to my experience Kvchosting.com is the best option to get SSD VPS hosting solutions. Reliability is highest, support is helpful and prices are reasonable.
I can highly recommend Vpsnine.com - decent and time-tested VPS hosting provider with different server locations choice.
Like many webmasters have pointed out, SolVPS.com have provided excellent and reliable service. Customer support has been extremely fast and helpful. The fact that this company cared enough to follow up even with the customer that may have had an issue, told me that they TRULY cared about ALL there customers.
I am using my income tax to finally get my mufflers. Anyone have a coupon or a good place to get them from that has good prices?
I know Kvchosting.com as one of the most professional and engaging technical professionals. I had a couple of questions during the initial setup, I received very quick and informative responses from the staff.
You can check the reviews of this web host at various web hosting forums. This will help you to know more about their server up-time, service reliability and support staff responsiveness. These all factors will help to choose the right host for your needs.
In case you wish to have other web hosts to compare the plans, I would suggest you to try out AccuWebHosting.com for quality Linux and Windows SSD VPS Hosting solutions. All VPS plans are backed up by 99.99 % up-time, 24/7/365 Fully Managed and Responsive support.


text:
#ifndef BSPMAP_INCLUDED
#define BSPMAP_INCLUDED

#include "Q3BspRenderHelpers.hpp"

/*
 *  Base class for renderable bsp map
 */

class BspMap
{
public:
    BspMap() : m_renderFlags(0)
    {
    }

    virtual ~BspMap()
    {
    }

    virtual void Init() = 0;
    virtual void OnRenderStart()  = 0;  // prepare for render
    virtual void Render()         = 0;  // perform rendering
    virtual void OnRenderFinish() = 0;  // finish render

    virtual bool ClusterVisible(int cameraCluster, int testCluster) const    = 0;  // determine bsp cluster visibility
    virtual int  FindCameraLeaf(const Math::Vector3f & cameraPosition) const = 0;  // return bsp leaf index containing the camera
    virtual void CalculateVisibleFaces(const Math::Vector3f &cameraPosition) = 0;  // determine which bsp faces are visible

    // render helpers - extra flags + map statistics
    inline void  ToggleRenderFlag(int flag)    { m_renderFlags ^= flag; }
    inline bool  HasRenderFlag(int flag) const { return (m_renderFlags & flag) == flag; }
    inline const BspStats &GetMapStats() const { return m_mapStats; }

protected:
    int      m_renderFlags;
    BspStats m_mapStats;
};

#endif

redpajama_set_name: RedPajamaGithub


text:
How To Fix A Canker Sore Fast
Fast Relief from Canker Sores Our Insight powered by
If he has a canker sore I put the oils in both of our mouths (pretending to put it on a sore in my mouth as well) and we lean over the sink and make silly loud sounds as we spit out the excess into the sink. It gets rid of the sores without pain to your child.... 1/11/2007 · Some canker sores are an allergic reaction to an ingredient in toothpaste. Try using Rembrandt brand of toothpaste and get the type that's labelled Extra Gentle because it does not contain the ingredient that causes canker sores. It is a bluish/aqua trim on white box and stated on the back that it is "made for mouths that are prone to canker sores." Ask the pharmacist to order it if they don't
72 Home Remedies for Canker sore
But before we get to that part, it helps to have a general understanding of what a canker sore actually is. In short, a canker sore is a shallow ulcer that forms in your mouth.... They will eventually go away on their own but, due to the pain they can cause, many people want to know hot to get rid of canker sores fast at home. Canker sores …
Cure Canker Sores FAST With These 8 Natural Remedies
Canker sore outbreaks can also be associated with nutritional deficiencies. Nutrient deficiencies related to zinc, folic acid, iron, selenium, and calcium. Nutrient deficiencies related to zinc, folic acid, iron, selenium, and calcium. how to fix backgroun sound in final cut Take the powder and apply it directly to your canker sore. I will burn extremely bad for about 1 minute, but after the pain will be alleviated for hours. Repeat as needed, but the canker sore will be gone in about 2, 3 days max.
What's a Canker Sore? How to Get Relief Water Tower
Over-the-counter products such as Zilactin-B Canker Sore Gel and Colgate Orabase Soothe-N-Seal form a long-lasting protective coating over the sore to speed healing and provide fast pain relief. how to fix traction alopecia With a weak immune system, your body cannot repair the area of canker sore quickly. The more time the canker sore is an open wound, the more chance of irritating and elongating the sore. The more time the canker sore is an open wound, the more chance of irritating and elongating the sore.
DenTek® Canker Cover® Canker Sore Relief Patch
How can I fix my canker sore fast? Yahoo Answers
Best Home Remedy For Canker Sores – Glady Medium
A canker sore is a small, painful ulcer with a yellow or white-gray center and a well-defined red border. It usually develops on the inside of the lip or cheek, and sometimes on the tongue, and hangs around for three to four days.
The sore should be dry (pat with tissue) if possible. Place the Canker Cover Patch on a clean, dry finger with the white side up. Place the white side on the sore and hold in place for 20 seconds. If sore is difficult to reach (in the fold between the cheek and gum or near the teeth or lip) break the patch along the score and use half. Some discomfort may occur during the first few minutes
Minor – Minor canker sores are small, oval or round ulcers that heal within 1-2 weeks without scarring. This is the most common type of canker sore. This is the most common type of canker sore. Major – Major canker sores are larger and deeper than minor sores.
Canker sore outbreaks can also be associated with nutritional deficiencies. Nutrient deficiencies related to zinc, folic acid, iron, selenium, and calcium. Nutrient deficiencies related to zinc, folic acid, iron, selenium, and calcium.
First, however, you need to be able to tell the difference between a canker sore and a cold sore, or fever blister, which is caused by the herpes virus.
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Bruce G. Li on How To Look Like Vin Diesel
Marlin on Sylveon How To Get Ultra Sun
Samanta Cruze on How To Get Ash Pikachu

redpajama_set_name: RedPajamaCommonCrawl


text:
i2c powers QNB Group's digital issuance for the Visa FIFA World Cup Qatar 2022™ prepaid card
Implementation demonstrates speed-to-market and the enablement of bespoke digital mobile financial solutions
News provided by i2c Inc.
December 16, 2022 09:45 Korea Standard Time
REDWOOD CITY, CALIF.--(Business Wire / Korea Newswire) December 16, 2022 -- i2c Inc., a leading provider of digital payment and banking technology, today announced its partnership with QNB Group, the Official Middle East and Africa Supporter of the FIFA World Cup 2022™ to power the digital issuance of the Visa FIFA World Cup Qatar 2022™ Prepaid Card.
By leveraging i2c's agile banking and payments platform, QNB Group is issuing virtual Visa prepaid cards to end users' mobiles, securely enabling digital and NFC-based contactless digital payments as well as Apple Pay.
"We are honored to support such an innovative and impactful use case in support of one of the world's most beloved events," said Amir Wain, founder and CEO of i2c. "By operating on our secure, highly-configurable platform, QNB Group is providing fans a great digital-first payments experience and an easy and simple way to pay."
"As the Official Middle East and Africa Supporter of the FIFA World Cup 2022™, we are extremely proud to bring this product to market and to be able to participate in the enhancement of the banking user experience. We are also grateful for our partnership and combined efforts with i2c," said Mr. Adel Ali Al-Malki, General Manager QNB Group Retail Banking of QNB Group. He also added, "Through their expertise, dedication and technology we were able to deliver a truly innovative product in record time and on the world's greatest stage."
More than one million visitors are expected to attend the month-long tournament which is being billed as the most payment-enabled FIFA tournament ever with more than 5,300 contactless payment terminals across official venues including eight stadiums.
About Qatar National Bank
Through its subsidiaries and associate companies, QNB Group extends to more than 30 countries across three continents providing a comprehensive range of advanced products and services. The total number of employees is 27,000 operating through 1,000 locations, with an ATM network of more than 4,700 machines. For more information visit qnb.com
About i2c Inc.
i2c is a global provider of highly-configurable payment and banking solutions. Using i2c's proprietary "building block" technology, clients can easily create and manage a comprehensive set of solutions for credit, debit, prepaid, lending and more, quickly and cost-effectively. i2c delivers unparalleled flexibility, agility, security and reliability from a single global SaaS platform. Founded in 2001, and headquartered in Silicon Valley, i2c's next-generation technology supports millions of users in more than 200 countries/ territories and across all time zones. For more information, visit www.i2cinc.com and follow us at @i2cinc.
Website: http://www.i2cinc.com/
i2c Inc.
Christine Alemany
All releases from i2c Inc.
i2c Named "Best in Class" Credit-Card-as-a-Service Provider by Aite-Novarica
i2c Partners with Fintech Unicorn PingPong to Power Rapidly Growing B2B Mastercard Credit Offering
i2c Partners with Wirex to Expand Prepaid Crypto Card to the US


For use with Rainwave timers only!
Moisture meter does not require batteries to operate. RED ZONE: Plants require little water- water only when dry and needle goes below halfway mark in RED zone. GREEN ZONE: Plants require regular watering - when needle drops halfway in GREEN zone. BLUE ZONE: Plant requires no water.
Monitor how much water you use with this flowmeter. Attaches between the faucet and the hose and is activated with the simple twist. Turn the knob to the amount of water you wish to use and the unit will turn off when that amount is achieved. Ideal for newly planted trees and shrubs.


Catering Services are usually handled by hotels, pubs or restaurants that serves food for many occasions such as wedding or reception, birthday parties, new year celebrations, graduation day parties, or a farewell, and for other functions or occasions. If you need appreciation for conducting parties, then you must first focus on hiring good catering services. Else, the effort you put to make your party decoration attractive, would bring failure to attract the party attenders.
Not just wall or stage decoration, but even decorating food in a attractive way becomes important. And this will be taken care-off by the caterers in Godhra.
Thus, if you want your function or party to be memorable event, by serving delicious mouthwatering dishes, you need to approach these caterers in Godhra to please your guests. You can find several popular catering services in Godhra, which are listed below.
Hope the above information is enough for you to find the excellent catering services in Godhra.


text:
Last month, the music world faced yet another tragedy with the untimely passing of Juice WRLD, who died at the age of 21. Now, a coroner has...
Jay Electronica Reveals Toronto and Montreal Shows
It is the year 2020, and we still don't have a Jay Electronica album (let alone that project with JAY-Z), but fans in Eastern Canada will ha...
TOBi Gets the Game for His "City Blues" Remix
Not even a full year removed from sharing his Still album, TOBi has shared a remix of album cut "City Blues" featuring the Game. The Lago...
Eminem Music to Be Murdered By
There were rumours of a new album that casually popped up throughout 2019, but at no point was it suggested that Eminem would release a surp...
GZA / Killah Priest / Raz Fresco Commodore Ballroom, Vancouver BC, January 20
GZA's sophomore album, Liquid Swords, is not only one of the best solo Wu-Tang Clan releases, it's a hip-hop classic on its own. This year i...
Watch PARTYNEXTDOOR Save Toronto in His Claymation Video for "Loyal" with Drake
PARTYNEXTDOOR gave us his Drake-featuring "Loyal" late last year, and now the pair are revisiting the song for a new video. As you'll wit...
Mac Miller Circles
There is so much potential for disaster on posthumous albums. But Circles, the final effort from the deeply missed Mac Miller, sets a new st...
Behold Insane Clown Posse's "Frothy Whoop Dub" Clown Craft Beer
Insane Clown Posse are just over a month away from kicking off another decade of fandom and community with Juggalo Weekend 2020, and ahead o...
Stream Mac Miller's Posthumous Album 'Circles'
Mac Miller's posthumous album Circles has arrived, and you can stream his final collection now. Before passing away at the age of 26, Mil...


4 years agoUpdate expectations of SRW-Z39.50 diagnostic mapping.
Update expectations of SRW-Z39.50 diagnostic mapping.
This has actually changed in YAZ.
to fetch handler and handler must set it to return a record.
6 years agoEXTRA_RESPONSE_DATA for search+scan.
This is for SRU only .
6 years agoAdded support for returning the display term as part of a scan response.
Added support for returning the display term as part of a scan response.
file - given by option -c.
Fixes crash one some older versions of Perl.
7 years agoDescribe clarification of licence terms.
Describe clarification of licence terms.
This is same license as YAZ.
5. Nothing relevant seems to have changed.
should avoid ICU-version Dependency Hell.
8 years agoDo not include IDMETA in distribution.
Do not include IDMETA in distribution.
8 years agoMANIFEST.SKIP ignores git crud instead of CVS crud.
MANIFEST.SKIP ignores git crud instead of CVS crud.
8 years agoBack to sleeping only one second -- didn't help to go higher.
Back to sleeping only one second -- didn't help to go higher.
that means that the whole build fails. Hopefully this will fix that.
8 years agoIgnore SimpleServer.o in git.
9 years agoRemove present handler's setting of HITS=0 in argument hash.
Remove present handler's setting of HITS=0 in argument hash.
9 years agoDo not set hits member of bend_present_rr.
Do not set hits member of bend_present_rr.
YAZ 4, so this should have no effect.
systems. For amd64 architectures and others this may be different from int.
this is an Index Data build.
around. It wouldn't be so bad if it was restricted to the "debian"
10 years agoIgnore failure of rmdir.
Simple Perl API for building Z39.50 servers.


Paying your way through college, especially with the staggering prices of tuition fees can be overwhelming, if not discouraging, for some. Luckily, there are more affordable, cost-efficient ways that are available, such as financial aid and scholarships.
In a typical American family, their primary source of funding for college tuition fees is grants and scholarships. Usually, grants and scholarships are the two types of financial aid that do not need to be reimbursed in the future.
However, steering through the entire financial aid process can be tricky. This guide will walk you through with the basics so that you can pay off college through financial aids and scholarships, and helping you achieve your goals.
Financial aids help you and your family pay off your college expenses such as tuition fees, books, school supplies, lodging, and transportation. These are usually in the form of scholarships, grants, work-study programs, and private and federal loans.
These types of aids usually come in a variety of sources ‒ foundations, colleges, high schools, federal and state agencies, to name a few. The total amount a student receives depends on a variety of factors, such as institutional, state and federal guidelines.
First and foremost, file the FASFA, or also known as the Free Application for Federal Student Aid ‒ the application for applying for federal student aid. You can check the Department of Education's website, where you can fill out the free application form, as well as keep track with the latest announcements. Usually, students and families can begin filling out forms as early as October 1 for the subsequent academic year. The deadline for the federal financial aid is generally on June 30, but other schools and universities that utilize FASFA have earlier deadlines.
Some schools such as private colleges require an additional form, the College Scholarship Service Profile, for them to know their financial aid funds. The fee for a CSS Profile as of the school year 2018 to 2019 is $25. Any additional report cost for about $16.
According to certified financial planner Joseph Orsolini, there are only about 250 colleges that need the CSS Profile (elite colleges.) These schools, according to Orsolini, will dig deeper into your family's overall finances. It takes into consideration assets and properties that are otherwise, excluded from the FAFSA. For example, it counts the total value of your family home and other small businesses.
Students can also be eligible for a state, institutional, federal and private aid. These four main sources usually come from the state and federal government, institutions, and other private organizations.
One of the biggest financial aid providers, the federal government offers grants, loans, and work-study funds. Students who are interested in filing this type of aid must submit the Free Application for Federal Student Aid (FAFSA).
Just like the federal government, the state also offers students loans, grants, scholarships, tuition assistance, and work-study funds.
A private aid comes from private sources such as religious, cultural, professional and service organizations. These are usually in the form of loans and scholarships.
This type of aid usually comes from a form of financial assistance, one that is offered by the school. It often varies, since different colleges and universities have different procedures when it comes to establishing their financial aid.
There are four main financial aid types for students- scholarships, loans, grants, and work-study funds.
Scholarships usually do not require repayment. Some institutions and private organizations offer them and can be based on a variety of factors such as athletic ability, academic performance, race, religious affiliations, to name a few.
Grants, like scholarships, do not to be repaid later on. These are usually offered by the state and federal government, as well as some institutions. They are either need-based, merit-based or student-specific. Student-specific grants are traditionally given to students with disabilities, women and other minorities.
Both the government and private institutions usually offer loans. Loans are the money that you borrow to put you through college. However, you need to repay these loans in a given term with added interest rates.
Loans allow students and their respective families to gain access to funds that will help put a student through college.
Subsidized Loans – Loans that are granted for students that demonstrate financial need. While a student is in school, the Department of Education pays off the interest, with a six-month grace period after graduation.
Unsubsidized Loans – Loans that are made available to students regardless of their financial need. They are usually the ones responsible for paying interest rates.
Private loans are loans that are usually granted by private banks. The eligibility for applying for this type of loan largely depends on one's credit score. Take note that private loans typically have higher interest rates than government loans.
A work-study program is where a student earns money to help pay off school. This type of program usually gives students federally funded jobs found on campus or designated locations. Some facilities on campus employ work-study students, and the pay usually varies.
With the rising costs of college education, getting financial aid can make can make a significant difference in the debt that you need to pay off after graduation. That's why, at this stage, you need to be resourceful as much as you can. Explore all the possible options to fund your college tuition fees and other expenses. If you do that, there is a greater chance that you can maximize the financial aid that you'll receive.
Now that you are aware of the different financial aid that is available to support you in your studies, the next step is to check for available financial aid opportunities out there, allowing you to utilize all the available resources to support and fund your college education.


text:
Nitroz #7949
atxmartin #8860 atxmartin #7937 GabeLogan #7380
« first ‹ previous Page 1 of 2 next › last »
legendary-arrow-6353 25 Dec 2021, 1:17 a.m. Warpless Finished recorded 2 entrants 0:42:57.1
fancy-aullos-3615 25 Dec 2021, 12:10 a.m. Warpless Finished recorded 2 entrants 0:52:06.4
puzzled-turtle-5821 24 Dec 2021, 11:04 p.m. Warpless Finished recorded 2 entrants 0:50:18.6
reliable-seashell-9518 24 Dec 2021, 10:09 p.m. Warpless Finished recorded 2 entrants 0:51:45.6
splendid-facade-8637 24 Dec 2021, 12:15 a.m. Warpless Finished recorded 2 entrants 0:56:02.3
prudent-manbo-2409 20 Dec 2021, 7:09 p.m. Warpless Finished recorded 2 entrants 0:48:13.5
curious-face-0019 26 Sep 2021, 6:35 p.m. Warpless Finished recorded 2 entrants 1:05:01.7
amazing-aullos-7749 21 Sep 2021, 9:42 p.m. Warpless Finished recorded 3 entrants 1:03:55.9
sleepy-sword-9145 19 Sep 2021, 9:45 p.m. Warpless Finished recorded 5 entrants 1:27:25.4
fearless-wind-8105 16 Apr 2021, 10:43 p.m. Warpless Finished recorded 2 entrants 0:47:00.1
Try our hot sauce! Nah, just kidding.


text:
Wage growth slows to 9.1 percent
Written by MTI
Year-on-year wage growth in Hungary slowed to 9.1 percent in August from 10.8 percent in July, data released by the Central Statistical Office (KSH) on Friday show.
31. October 2020 9:11
In absolute terms, the average gross monthly wage for full-time employees stood at 391,600 forints (EUR 1,063). The average net wage was 260,400 forints.
Calculating with twelve-month CPI of 3.9 in August, real wage growth stood at 5.0 percent.
Excluding the 90,400 Hungarians in fostered work programmes — who earned on average gross 81,700 forints in August — the average gross monthly wage in Hungary was 402,400 forints.
The average gross wage in the business sector, which includes state-owned companies, rose by 9.9 percent to 407,500 forints, excluding fostered workers. The average gross wage in the public sector, excluding fostered workers, increased by 7.1 percent to 393,700 forints.
For the period January-August, wage growth reached 9.9 percent.
People working in the ICT sector were the highest earners, getting a monthly gross 657,600 forints, while Hungarians in the commercial accommodations and catering sector had the lowest monthly pay of 251,700 forints.
KSH noted that men earned, on average, about 18.4 percent more than women in January-August.
Commenting on the data, state secretary for employment policy Sandor Bodo said the wage growth seen in the period January-August was as rapid as in previous periods. However, inflation reached 3.5 percent over the past eight months, he told public news channel M1, adding that there were signs that wage growth would slow in the coming period.
Wages in Budapest remain significantly higher than in other parts of the country, with those employed in the capital making over 20 percent more than workers in Gyor-Moson-Sopron County, Bodo said.
GDP could be down by 6.4 pc in 2020
Looking for the best country for European company formation?


text:
Catalog Record: The ocean, atmosphere, and life. Being the second series of a descriptive history of the life of the globe | HathiTrust Digital Library
The ocean, atmosphere, and life.
Being the second series of a descriptive history of the life of the globe.
By Élisée Reclus. Illustrated with two hundred and fifty maps or figures, and twenty-seven maps printed in colors.
Reclus, Elisée, 1830-1905.
New York, Harper, 1873.
Human geography.
Biogeography.
Climatology.
Meteorology.
Ocean.
534 p. illus., maps (part col.) 24 cm.
Full view Library of Congress
Full view New York Public Library
The ocean, atmosphere, and life. Being the second series of a descriptive history of the life of the globe.
The earth: a descriptive history of the phenomena of the life of the globe.
The ocean, atmosphere and life : being the second series of a descriptive history of the phenomena of the life of the globe /
Reclus, Elisée, 1830-1905,
Reclus, Elisée, 1830-1905.
Earth; phenomena of the life of the globe;
The earth; a descriptive history of the phenomena of the life of the globe,
The earth : a descriptive history of the phenomena of the life of the globe /
The earth, a descriptive history of the phenomena of the life of the globe.


For a long time, I've wanted to find some way to spread the word about issues I care about and let people know that there are simple ways to get involved and make a difference. So, as long as Lisa is willing to let me be a guest blogger, I see my mission as, not only to alert you to issues I care about but to provided ways you can DO SOMETHING ABOUT IT.
I'm on the Moveon.org mailing list http://Moveon.org. They just sent a letter letting me know that their campaign to roll back the FCC's recent rules changes needs everyone's help and I thought I'd pass on their concerns to those of you not already on their mailing list. They need to put more pressure on the Senate in the next few days to get them to vote to roll back the recent FCC's changes that would allow a few big companies to control our country's airways.
Later this week or early next week, the Senate will likely take up its last major vote on media reform, and it'll be very close. After a grassroots groundswell tipped the balance toward rolling back the FCC rule change that would allow greater media concentration, lobbyists from big media conglomerates have been working around the clock to tip it back.
Together, we can make sure that America's media is diverse, competitive, and balanced.
The final steps: Volunteer: We need your help. If you have some time to give, press here.
Donate: If you can't give time, can you make a financial contribution to support this campaign?


text:
Professor of Music, Composition
gfh2107@columbia.edu
Georg Friedrich Haas joined Columbia University's composition faculty as a full-time tenured professor in September 2013. This appointment promises to sustain and enhance our composition program's reputation as one of the strongest, most progressive, and most international such programs in the United States.
Haas has emerged as one of the major European composers of his generation. His music synthesizes in a highly original way the Austrian tradition of grand orchestral statement with forward-looking interests in harmonic color and microtonal tuning that stem from both French spectralism and a strand of American experimentalism. The result is an exploratory, uncompromising music that is also sensuously attractive. His music appeals to unusually diverse constituencies, from avant-garde composers for its microtonal investigations to casual listeners for its spacious forms and euphonious harmony.
Haas's hour-long in vain, for 24 musicians, is widely regarded as one of the most original and path-breaking new compositions in the past quarter century. Another important work is limited approximations, for orchestra and 6 microtuned pianos. He has composed several operas and concertos and a variety of chamber works, including seven string quartets. He has received numerous national and international prizes, including the Kompositionspreis of the SWR Symphony Orchestra (2010) for limited approximations and the Grand Austrian State Prize for Music (2007), the country's highest artistic honor.
Professor Haas comes to Columbia after having held dual professorships at the Hochschle für Musik in Basel, Switzerland, and the Kunstuniversität in Graz, Austria.
Georg Friedrich Haas is published by Universal Edition.


The mission of South Central's pediatric physical therapist is to promote the highest quality of life for all children with developmental disabilities and their families. Grace Brunk, a pediatric physical therapist at South Central, explains that some common reasons that parents seek physical therapy for their children are cerebral palsy, down syndrome, maybe they aren't walking at the same time as other kids their age, and maybe there is some kind of movement dysfunction. After a referral from your pediatrician, the first step is to have a physical therapy evaluation. They will get the parents to communicate the child's birth history, any issues they had at birth, any surgeries, or anything that would impact the therapist's care as well as what is their concern. The therapists will do a good examination of the child, and then they will develop a treatment plan to address the issues found during the examination. The earlier a child begins physical therapy, the greater the impact therapy can have.
To learn more, call (601) 399-0534 or visit scrmc.com.


Japanese band BAND-MAID has announced to return to America and Europe for a tour including lives in five countries.
BAND-MAID has formed back in summer of 2013 and consists of 5 female band members: vocal and guitarist Miku, vocal Saiki, guitarist Kanami, bassist MISA and drummer Achi. In March 2016 the band travelled abroad for the first time to be part of Sakura-con that took place in Seattle, USA. Only two months later they headed over to London for their first performance in Europe at MCM London COMIC-CON.
In addition to Regular tickets that you can buy as of tomorrow, July 29th 10am (CEST) you will be able to buy a VIP ticket that includes early entrance, meet&greet with the band, signed photo and a limited DVD. Keep an eye on B7Klan's facebook for more information!


This is one of my favorite newer vintage tops. It has metallic gold threaded into it adding a lovely look-at-me sheen to it! To add an updated twist, I wore it with a spicy mini and platform heels. I like to balance out the long-sleeve covered-up tops with smaller skirts for night-time. I wear conservative clothes all week for work and like to show some skin for a night out! Since I am an avid fan of COLOR, I added some red lips for a 'lil something something to my otherwise black/gold outfit.


This bill would allow a person who is issued a protective order to conceal carry a firearm for up to 120 days after the order was issued, without needing a concealed firearm permit.
This bill makes a firearm owner liable for damage caused by their firearm if they share it with another person whose conduct is a felony.
This bill protects the right of an intoxicated person to carry firearms under certain circumstances.
This bill ensures that even alleged felons can defend themselves against aggression that is unrelated to their criminal activity.


Let Paradise Doves help you add drama to your event, as our white doves of celebration wing their way out of their baskets, circle spectacularly overhead, and return to their home in West Richland, Washington.
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Copyright 2002 Paradise Doves. All rights reserved.


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text:
Urban property sector following demographic push, pull
Wang Ying
Updated: May 27,2021 09:34 China Daily
Demand for new homes is rising steadily in top Chinese cities and major city clusters, thanks to the country's rapid urbanization pace, according to the country's recently released seventh national census, experts said.
The census, the largest of its kind across the world, was conducted last year and published on May 11. According to the National Bureau of Statistics, the number of people on the Chinese mainland currently stands at 1.41 billion, up 5.38 percent from the previous census conducted in 2010.
In total, about 370 million people are living and working in cities outside of their hometowns, up 69.73 percent from a decade ago.
The growing migrant population has also shed light on the country's future urban living patterns, with a higher proportion of people opting for houses in major cities and their surrounding areas, including city clusters within the Yangtze River Delta region, the Guangdong-Hong Kong-Macao Greater Bay Area, the Beijing-Tianjin-Hebei region, as well as the Chengdu-Chongqing dual city cluster, said Xu Xiaole, chief market analyst with Beike Research Institute.
The higher proportion of younger people migrating to the larger cities will lead to a significant increase in new home demand, as these people settle down, get married, and have children, said Yan Yuejin, director of the Shanghai-based E-house China Research and Development Institution.
The number of people aged 14 and below rose by 1.35 percentage points in the last 10 years and accounted for 17.95 percent of the nation's total population. The number of people in urban areas aged between 35 and 60 is expected to increase by 5 percentage points in the next decade, fueling additional demand for homes, Xu said.
The higher population, especially in the 60 years and above age group, which grew by 5.4 percentage points from 2010, has triggered demand for apartments that are in convenient locations with necessary facilities and access to retail outlets as well as eldercare facilities, Yan said.
Experts also expect greater demand for small homes as an increasing number of young people are choosing to stay single or delay their marriage. A decade ago, an average Chinese family had 3.1 members, while the latest census puts it at 2.62 members per family.
Taking all the factors into consideration, over the next 10 years, about 1.3 billion square meters of gross floor area for new homes will be sold every year, said Xu. Existing home sales during the same period are set to expand from 6 trillion yuan ($930 billion) at present to 10 trillion yuan.
The demographic changes will also affect housing demand on a regional basis, experts said.
East China, which has seen rapid urbanization in the last decade, is now one of the most preferred locations in the country for real estate purchases. Looking forward, development of such areas will continue to sustain urbanization as more people relocate to these regions for a better living and working environment, Yan said.
Central China, where the local infrastructure is seeing steady improvement, is another area that is expected to see a lot of investment in the future.
The census results have also indicated opportunities as well as challenges for different regions in the country.
East China not only accounted for the biggest chunk of the nation's population, but also saw its weighting in the nation's population rise by 2.15 percentage points over the levels in 2010.
This is in stark contrast to Northeast China, whose residents accounted for the lowest proportion of the Chinese population, with their weighting falling by 1.2 percentage points from a decade ago.
Thirteen of the 31 provinces, autonomous regions, and municipalities in the Chinese mainland saw their weighting in the total population decline. Liaoning, Jilin, Heilongjiang, Shanxi, and Gansu provinces as well as the Inner Mongolia autonomous region, reported actual population declines.
All of these factors will undermine demand in the local property markets, said a report published by consultancy TopSur.
Better housing, emergency response help minimize earthquake damage
Program helps save water in urban areas
China's home prices slightly up in April


text:
A Super Bowl IX az 1974-es NFL-szezon döntője volt. A mérkőzést New Orleansban, a Tulane Stadionban játszották 1975. január 12-én. A mérkőzést a Pittsburgh Steelers nyerte.

A döntő résztvevői

A Pittsburgh Steelers az alapszakaszból 10–3–1-es mutatóval került a rájátszásba az AFC-ből. A konferencia-elődöntőben otthon a Buffalo Bills ellen, majd a konferencia-döntőben idegenben az Oakland Raiders ellen győzött. A Steelers először játszott Super Bowlt.

A Minnesota Vikings is 10–4-es teljesítménnyel zárta az alapszakaszt az NFC konferenciában. A konferencia-elődöntőben otthon a St. Louis Cardinals ellen, majd a konferencia-döntőben szintén hazai pályán a Los Angeles Rams ellen győzött. A Vikings 1970-ben és 1974-ben játszott Super Bowlt, mindkettőt elvesztette.

A mérkőzés
A mérkőzést 16–6-ra a Pittsburgh Steelers nyerte, és története során először nyert Super Bowlt. A legértékesebb játékos a Steelers fullback-je, Franco Harris lett.

Jegyzetek

Források

További információk
 Az NFL hivatalos honlapja

Super Bowl 0009
1975 a sportban

redpajama_set_name: RedPajamaWikipedia


Welcome to the Nova Entertainment web site ("Web Site"). The Web Site is operated by Nova Entertainment Pty Ltd ACN 093 553 989 ("we" or "us" or "Promoterâ€).
4.1 When you are a Web Site account holder, you may submit various content, including videos, photographs, images and comments (collectively referred to as "User Generated Contentâ€) to the Web Site.
4.3 You must not include any image of, voice of, or personal information about any other person in any User Generated Content without that person's express consent. You warrant that if any such thing is included, you have obtained the express consent of the relevant person.
8.4 All Content is provided "as isâ€. We make no warranties or representation about any Content or information on the Web Site, either express or implied, and to the fullest extent permitted by law, we and our related companies (including Nova Entertainment exclude all warranties and representations about the currency, accuracy, suitability or reliability of any Content or information on the Web Site. We do not warrant that the Web Site is compatible with your computer equipment or that the Web Site or its server is free of errors or viruses, worms or "Trojan horses" and we are not liable for any damage you may suffer as a result of such destructive features.
11.3 Importantly, you must not use or apply any of our or Nova Entertainment's trade marks without our consent. Our trade marks include our name, our logos, our slogans and the names of our competitions.
1 These Terms of Entry apply to all promotions conducted by the Nova Entertainment group stations referred to in paragraph 53 below, which are not covered by Terms of Entry specific to that promotion. By entering, entrants accept these Terms of Entry. These Terms of Entry may be amended or replaced from time to time; entrants should check the Promoter's website (as specified in paragraph 53) for the current version.
2 Entry is open only to residents of the Australian state(s) where the promotion is being conducted who comply with any entry restrictions as specified by the Promoter. Directors, officers, management, employees and other staff (and the immediate families of directors, officers, management, employees and other staff) of the Promoter or of its related bodies corporate, or of the agencies or companies associated with this promotion or of any Australian commercial radio broadcaster are ineligible to enter.
3 An entrant who has won prizes to the value of $10,000 or more, in any promotion(s) run by the Promoter (or any related bodies corporate) in the previous six (6) months prior to their entry in this promotion is ineligible to enter this promotion and any entry will be deemed invalid, in the Promoter's sole and absolute discretion.
4 The promotion will be conducted during the promotion period specified by the Promoter.
5 To enter the promotion, entrants must, during the promotion period, follow the entry method specified by the Promoter.
6 Entries must be received by the Promoter during the promotion period. Entrants may submit up to the maximum number of entries specified by the Promoter. Multiple entries (where permitted) must be submitted separately and must independently comply with these Terms of Entry.
7 The Promoter accepts no responsibility for late, lost, incomplete, incorrectly submitted, delayed, illegible, corrupted or misdirected entries, claims or correspondence whether due to error, omission, alteration, tampering, deletion, theft, destruction, transmission interruption, communications failure or otherwise. The Promoter has no control over communications networks or services, the Internet, or computer or telephone networks or lines and accepts no responsibility for any problems associated with them, whether due to traffic congestion, technical malfunction or otherwise. The Promoter is not liable for any consequences of user error including (without limitation) costs incurred. Any form of automated entry using any device or software is invalid. Entries are deemed to be received at the time of receipt by the Promoter not at the time of transmission by the entrant.
8 If this promotion involves SMS entry, the maximum cost of each SMS is 55 cents (inc GST) and entries must be submitted from the entrant's mobile phone. SMS entry is only open to entrants with an SMS compatible mobile phone with calling line identification connected to a service provider which permits text and premium messaging to and from the promotional SMS number. Entrants should check with their network service provider to see if their mobile phone is compatible. Entrants under the age of 18 must obtain the bill payer's permission prior to entering. The Promoter's service provider is Salmat Digital Pty Ltd (helpline: 1300 131 276).
9 If this promotion involves entry via a promotion phone line, the maximum cost of a call to the promotion phone line is 55 cents (inc GST) except that higher rates may apply from mobile or public phones. Entrants under the age of 18 must obtain the bill payer's permission prior to entering.
10 Costs associated with accessing any station website remain an entrants responsibility and may vary depending on Internet Service Provider used.
11 The promotion will be drawn and/or decided at the time, on the date/s and at the location/s as specified by the Promoter. The prize/s will be awarded to a valid entrant or entrants (as applicable) who are randomly drawn or are deemed to have submitted the "best" entry, as determined by the judges, in accordance with the details specified by the Promoter regarding how the prize/s will be awarded.
12 The prize/s are as specified by the Promoter and their value will not exceed $1,000 (inc GST) each, with the total prize pool for the relevant blanket permit number stated below not exceeding $100,000 (inc GST).
13 If this promotion is a game of skill, chance plays no part in determining the winner/s and each valid entry will be individually judged (by representatives of the Promoter) based on the judging criteria specified by the Promoter.
(d) will, at the Promoter's reasonable request and at the Promoter's cost, at all times do all things (including signing all documentation) necessary to give full effect to the requirements of this clause.
15 Entries that, in the Promoter's judgment are offensive, defamatory or otherwise objectionable or inappropriate or that infringe any third party rights will be invalid.
16 The Promoter's decisions are final and no correspondence will be entered into.
17 Once an entry is submitted, entrants acknowledge that the entry may not be withdrawn, altered or deleted (except as and where required by the Promoter).
18 If the promotion involves a challenge as described by the Promoter (the Challenge), the Challenge will be conducted in accordance with the Challenge details specified by the Promoter and on the Challenge date at the Challenge location as specified by the Promoter. If an entrant participating in the Challenge is deemed, by representatives of the Promoter, to have completed the Challenge successfully within the time period specified by the Promoter (where applicable), and in accordance with any other criteria specified by the Promoter, they will receive a prize as specified by the Promoter. Unless otherwise specified, entrants are responsible for making their own way to and from the Challenge location to participate in the Challenge. If the Challenge location is specified to be an "entrant's home" or similar, the entrant warrants that the address nominated by the entrant is the address where the entrant lawfully and usually resides and that the entrant has authority to allow persons access to the home and the land on which it is situated. The entrant consents to the Promoter and any other persons as required by the Promoter accessing and entering the home and the land, for the duration of the Challenge and for any period before or after the Challenge, as reasonably required for the purposes of the Challenge. Unless the contrary intention appears, a reference in these Terms of Entry to the word "person" includes an individual, a firm, a body corporate, a partnership, a joint venture, an unincorporated body or association, or any government agency or entity.
19 Where a prize includes international or domestic travel, the prize cannot be taken during peak periods or any travel 'blackout' periods applying, and must be booked and completed as specified by the Promoter and/or the supplier or organiser of the prize. If the prize is event based, travel must be taken to coincide with the relevant event on the dates specified by the Promoter. Any flights and accommodation constituting part of a prize are subject to booking and availability. All costs associated with a travel prize which are not specified to be included in the prize, including but not limited to any transfer costs, meals, taxes, insurance and all other ancillary costs, are the responsibility of the winner and their companion/s (if any). The winner and any travelling companion/s are responsible for ensuring that they have all necessary travel insurance and documents to travel to the relevant place (including a current passport and visas, if required). The Promoter is not responsible for any cancellation, delay or rescheduling of flights and any costs incurred as a result (including, without limitation, accommodation costs) will be the sole responsibility of the winner. Where a prize includes international travel, winners are advised to consult their healthcare professional regarding recommended immunisations and/or health checks prior to travelling and to check for travel warnings and any perceived hazards with appropriate authorities, including www.dfat.gov.au.
21 If the prize includes vouchers, all vouchers are valid until the voucher expiry date as specified on the voucher or by the provider of the voucher. Vouchers are subject to the conditions stipulated by the provider of the voucher. If the total value of a voucher is not used at the time of redemption, a new voucher may (subject to the conditions stipulated by the provider) be issued for the remaining amount. Any such further voucher is valid for the remainder of the original voucher expiry period. Vouchers cannot be redeemed for further vouchers.
22 If the prize includes tickets, all tickets are valid for the date or period as indicated on the tickets. Tickets are subject to the conditions stipulated by the provider of the tickets.
23 If a winner of a prize is under the age of 18 years (where entry by persons under 18 is permitted), the Promoter may, at its discretion, award the prize to the winner's parent or guardian (who is aged over 18 years).
24 The Promoter may, at its discretion, require any person taking any prize to be 18 years of age or over, or if a person is under the age of 18, require that that person be accompanied by a parent or legal guardian while taking the prize.
25 The Promoter may in its absolute discretion prohibit an entrant's participation in this promotion, cancel a prize or otherwise cease to provide any benefit of a prize to a winner and their companion/s if the winner (or their companion/s), in the opinion of the Promoter, is under the influence of alcohol or any other drug, behaves aggressively or offensively, or behaves in a manner which may diminish the good name or reputation of the Promoter, any of its related bodies corporate or any of its promotional partners (or of the business of the Promoter, any of its related bodies corporate or any of its promotional partners), is contrary to law or is otherwise inappropriate.
26 The Promoter encourages consumers to enjoy alcohol responsibly. Legal aged consumers are advised to consider the safe drinking levels recommended in the National Health and Medical Research Council Australian Alcohol Guidelines. A full version of the Guidelines is available at http://www.alcoholguidelines.gov.au/.
27 Entrants must, at the Promoter's request, participate in all promotional activity (such as publicity and photography) surrounding this promotion or the winning of any prize, free of charge, and sign any additional documents reasonably required by the Promoter to give effect to this condition. An entrant consents to the Promoter and its related bodies corporate using the entrant's name, likeness, image and/or voice (including photograph, film and/or recording of the same) in any media for an unlimited period of time without further notification, remuneration or compensation for the purpose of promoting, publicising or marketing the promotion (including any Challenge) (including any outcome), taking or using any prize and/or promoting any products or services manufactured, distributed and/or supplied by the Promoter.
28 If an entrant is unable to or refuses or fails to take part in any element of this promotion (including, but not limited to, any Challenge) or a winning entry is deemed not to comply with these Terms of Entry, the Promoter reserves the right to discard that entrant's entry and proceed as if that entrant had not entered the promotion.
• in all other states: on air and/or in writing.
By entering this promotion, each entrant requests that his or her full address not be published.
• in all other states: by the date and time as specified by the Promoter. If a date/time is not specified, prizes must be claimed within 3 months of the final draw/decision date.
Unless otherwise specified, winner/s must collect their prize/s from the Promoter's station address (as specified in paragraph 53).
31 If any prize is not claimed by the Prize Claim Date and Time in NSW, SA or QLD, the relevant winner's entry will be deemed invalid and the Promoter reserves the right to distribute the relevant prize/s by, for games of skill, awarding the relevant prize/s to the next best valid entry or entries (as applicable) or, for games of chance, by conducting such further draws at the location/s and on the date/s specified by the Promoter as are necessary to distribute the prize/s, subject to any directions given by any relevant authority. If any prize is not claimed by the Prize Claim Date and Time in VIC or WA, the relevant winner's entry will be deemed invalid and the unclaimed prize/s will be distributed at the Promoter's discretion. If required by law or any relevant authority, the winner/s will have their name and state of residence published in accordance with paragraph 29 above. If a prize is no longer capable of being redeemed, the new winner/s will receive a prize, as determined by the Promoter, of equivalent value (as if the original prize had been awarded to that person, less any administrative expenses incurred by the Promoter), subject to the approval of the relevant authorities in the relevant state, if required.
32 Entrants acknowledge that there may be inherent risks in some aspects of the promotion (including, but not limited to, any Challenge) or the prize and that participation in the promotion (including, but not limited to, any Challenge) and/or using the prize may involve participating in dangerous activities. By entering this promotion and/or accepting the prize, entrants accept that risk.
33 In order to participate in this promotion, any Challenge and/or the activities which may be awarded as part of the prize, the winner (and their companion/s, as applicable) must comply with applicable height, weight, health, fitness, skill, balance, dexterity and any other requirements normally associated with the particular activity. It is the entrant's responsibility to ensure that they (and their companion/s, as applicable) are sufficiently healthy and fit so as to safely participate in this promotion, any Challenge and/or undertake the activities awarded as part of the prize. The Promoter reserves the right to deem that an entrant/winner (or their companion/s, as applicable) is not sufficiently healthy or fit. The entrant/winner must comply with all requirements and directions of the people responsible for the conduct of the relevant activity and must ensure that their companion/s also comply, if applicable.
34 If requested by the Promoter, any entrant or winner (and their companion/s, if applicable) (or if an entrant, winner or companion is aged under 18 years, their parent or guardian) must sign an indemnity and exclusion of liability form (provided by the Promoter) in favour of all parties involved in this promotion and/or providing the prize prior to undertaking any specified activities forming part of the promotion or prior to taking a prize. If any entrant, winner, nominated companion/s or parent/guardian (if applicable) do not sign the indemnity form provided by the Promoter within the time requested by the Promoter, the relevant entrant's or winner's entry or claim will be deemed invalid. Where a winner's entry or claim is deemed invalid, the Promoter reserves the right to determine a new winner in accordance with paragraph 11 or 18 (as applicable).
35 Prizes and participation in this promotion is subject to any conditions imposed by the supplier or organiser of the prize, as applicable.
36 The Promoter and its associated agencies and companies will not be liable for any direct or indirect loss (including, without limitation, special or consequential loss or loss of profits), expense, damage, personal injury or death which is suffered or sustained (whether or not arising from any person's negligence) in connection with this promotion, any Challenge or accepting or using any prize, except for any liability which cannot be excluded by law (in which case that liability is limited to the minimum allowable by law). Applicable manufacturers and/or distributors should be contacted in regards to all prize warranty claims.
37 Without limiting the previous paragraph, the Promoter and its associated agencies and companies will not be liable for any damage to or delay in transit of prizes. Prizes will be provided by the Promoter to the winner/s in the manner notified by the Promoter.
38 Entrants can only register in their own name. Entrants who provide incorrect, misleading or fraudulent information are ineligible to enter and participate in the promotion and all entries of an entrant who is deemed by the Promoter to have provided incorrect, misleading or fraudulent information may, at the sole discretion of the Promoter, be deemed invalid. The Promoter may require the winner/s to provide (within the requested time) identification as requested by the Promoter including (without limitation) proof of identity, proof of age and proof of residency (to the Promoter's satisfaction, at its sole discretion) in order to confirm the entrant's identity, age, residential address, eligibility to enter, participate and claim a prize, and any information submitted by the entrant in entering and participating in the promotion, before issuing the prize (including confirming consent of an entrant's parent or legal guardian and the name, age and address of the parent or legal guardian that gave their consent, where an entrant is under 18 years of age). Identification considered suitable for verification is at the Promoter's discretion. If the documentation required by the Promoter is not received by the Promoter (or its nominated agent) or an entrant has not been verified or validated to the Promoter's satisfaction, then any and all entries of that entrant will be ineligible and deemed invalid.
39 If due to any reason whatsoever the Promoter becomes aware after an entrant has won a prize that the entrant has not complied with these Terms of Entry, that entrant will have no entitlement to the prize, even if the Promoter has announced them as a winner and that entrant will be required, at the direction of the Promoter, to return, refund or otherwise make restitution of the prize.
40 The Promoter reserves the right to verify the validity of any and all entries. The Promoter may, in its sole discretion, disqualify any or all entries from, and prohibit further participation in this promotion by, any person who: (a) tampers with or benefits from any tampering with the entry process or with the operation of the promotion; (b) acts in violation of these Terms of Entry; (c) acts in a disruptive manner; (d) acts with the intent to annoy, abuse, threaten or harass any other person; or (e) engages in any unlawful or other improper misconduct calculated to jeopardise the fair and proper conduct of the promotion. The Promoter's legal rights to recover damages or other compensation from such an offender are reserved.
41 This prize must be taken as offered and cannot be varied. No prize is transferable or exchangeable, nor can it be redeemed for cash (unless otherwise indicated). In the event for any reason a winner does not take an element of any prize at the time stipulated by the Promoter then that element of the prize will be forfeited by the winner and cash will not be supplied for that element of the prize. The Promoter accepts no responsibility for any variation in prize value. Where a prize is unavailable for any reason, the Promoter may substitute for that prize another item of equal or higher value as determined by the Promoter, subject to the approval of any relevant authorities (if required). Without limiting the foregoing, the Promoter may, in its absolute discretion, substitute cash for any prize (the amount of cash being equal to the prize value).
42 Without limiting paragraph 36, the Promoter and its associated agencies and companies make no warranties or representations about the fitness for purpose or suitability of any prize and will not accept responsibility for the quality or fitness for any purpose of any prize, or the failure of any prize to be of merchantable quality. If liability under terms implied by legislation cannot be excluded, the liability of the Promoter and its associated agencies and companies is limited to re-supplying the relevant goods or services or paying the cost of replacing them.
43 If for any reason any aspect of this promotion is not capable of running as planned for any reason beyond the reasonable control of the Promoter, including, but not limited to, by reason of war, terrorism, state of emergency or disaster (including natural disaster), infection by computer virus, telephone network failure, bugs, tampering, unauthorised intervention, fraud, technical failures or anything which corrupts or affects the administration, security, fairness, integrity or proper conduct of this promotion, the Promoter may, in its sole discretion, cancel, terminate, modify or suspend the promotion, invalidate any affected entries and/or, if necessary, provide an alternative prize to the same value as the original prize, subject to the approval of the relevant authorities in each relevant state, if required.
44 Without limiting any other paragraph, the Promoter may, at its sole discretion, amend any aspect of this promotion or of these Terms of Entry from time to time, subject to applicable laws and subject to the approval of the relevant authorities in the relevant state, if required.
45 The Promoter accepts no responsibility for any tax implications that may arise from the prize winnings. Independent financial advice should be sought. Where the operation of this promotion results in, for GST purposes, supplies being made for non-monetary consideration, entrants agree to follow the Australian Taxation Office's stated view that where the parties are at arm's length, goods and services exchanged are of equal GST inclusive market values.
46 Each entrant must ensure that any other person whose personal details have been provided by the entrant to the Promoter for the purposes of the entrant's participation in this promotion has given their implied or express consent for their details to be provided to the Promoter and any of its related bodies corporate and to be contacted by the Promoter or any of its related bodies corporate in relation to this promotion.
48 The Promoter will provide to the entrant, at time of entry into the promotion, a collection statement that details the Personal Information being collected, the purpose of its collection and how it will be shared with third parties. The collection statement will comply with the Promoter's disclosure obligations under the Privacy Act 1988 (Cth) as amended by the Privacy Amendment (Enhancing Privacy Protection) Act 2012 (Cth). By entering and participating in the promotion in the manner required, entrants agree to the collection and disclosure of their Personal Information in accordance with the collection statement.
49 By entering this promotion, an entrant also acknowledges that a further primary purpose for collection of the entrant's Personal Information by the Promoter is to enable the Promoter to use the information to assist the Promoter in improving goods and services and to contact the entrant in the future with direct marketing materials, including information on special offers or to advise the entrant of the Promoter's other programs, products, services, events or activities that the Promoter believes the entrant may be interested in, via any medium including mail, telephone and commercial electronic messages (SMS (Short Message Service), MMS (Multimedia Message Service), IM (Instant Messaging) and email) or any other form of electronic, emerging, digital or conventional communications channel whether existing now or in the future. The Promoter may share information with trusted third parties who may contact the entrant with special offers in this way where the entrant has provided their consent at the time of entry. By registering in the promotion, an entrant acknowledges and agrees that the Promoter may use the entrant's Personal Information in the manner set out in this condition.
50 Unless the contrary intention appears, a reference in these Terms of Entry or in any advertisement relating to this promotion, to Australian dollars, dollars, AUD$ or $ is a reference to the lawful currency of Australia.
51 Where this competition is communicated and/or conducted via a social media platform (including, but not limited to, Facebook, Instagram and/or Twitter), entrants acknowledge that use of social media platforms generally is subject to the prevailing terms and conditions of use of the social media platform (including, but not limited to, Facebook, Instagram and/or Twitter). The promotion is in no way sponsored, endorsed or administered by, or associated with, any social media platform (including, but not limited to, Facebook, Instagram and/or Twitter). The winner and their companion(s) (if any) are solely responsible and liable for the content of their entries and/or posts and any other information they transmit to other Internet users. To the extent permitted by law, the winner and their companion(s) (if any) agree to indemnify, defend and forever hold harmless any and all social media platforms (and their associated agencies and companies) (including, but not limited to, Facebook, Instagram and/or Twitter) used in conjunction with this promotion, against any and all losses, actions, claims, costs, expenses and damages (of any nature) which may be incurred by the winner and their companion(s) (if any) in respect of the winner's and their companion(s)' (if any) participation in the promotion and any prize. Any questions, comments or complaints about the promotion must be directed to the Promoter and not to any social media platform used in conjunction with this promotion (including, but not limited to, Facebook, Instagram and/or Twitter). Entrants understand that they are providing their information to the Promoter and not to any social media platform (including, but not limited to, Facebook, Instagram and/or Twitter).
52 Where a prize includes an Apple product, entrants acknowledge that Apple is not a participant in or sponsor of this promotion.
54 By entering this promotion, an entrant consents to their voice, name, location and any other information submitted to the Promoter being broadcast on air and/or published online, and each entrant consents to the content of their entry being broadcast on air and/or published online.
"Personal Information" means, for the purpose of the Privacy Act 1988 (Cth) as amended by the Privacy Amendment (Enhancing Privacy Protection) Act 2012 (Cth), information or an opinion about an identified individual, or an individual who is reasonably identifiable, whether the information or opinion is true or not and whether the information or opinion is recorded in a material form or not.


They didn't look at it as redemption for last year, they just went out and won it for this year. And in the process, the Maryland Terrapins women's lacrosse team made history with an undefeated season to go with their third national championship in four years as they beat Boston College, 16-13 in Gillette Stadium in front of a record-breaking championship game crowd of 11,668. It is Maryland's 14th National Championship in program history.
Caroline Steele also put her name in the record books individual with six goals, tying the championship game record. Maryland needed them against a tough Boston College team, especially considering their own star player Kenzie Kent had five goals and five assists in the game.
Steele's goals were split evenly between the first and second half, but especially in the first half where Maryland totaled only five goals on 25 shots, her scores were crucial in helping Maryland keep it level at the break. She then scored two more in a vital five-goal Maryland run to open the second half that gave them enough of a cushion to withstand Boston College's run at them.
Just ten seconds into the game, freshman Kali Hartshorn ran straight to the net off a pass from Tewaaraton Award finalist Zoe Stukenberg. Hartshorn put the ball into the goal and set the record for the fastest score in Maryland history.
Just a minute after that goal, Taylor Hensh collected a rebound off a shot and sent the ball back into the net accurately to give Maryland a quick 2-0 lead.
Boston College wouldn't let the Terps run away with things, though. Sam Apuzzo put the Eagles on the board four minutes into the match after a perfectly-timed pass by Kent. While Hartshorn was winning draw controls, which ultimately aided in Maryland's scoring opportunities, some early ground ball pickups by the Eagles likewise gave them some chances.
After a save by Eagles goalkeeper Zoe Ochoa, Apuzzo tied the game after cutting inside and finishing a pass from midfielder Kaileen Hart.
That was when Steele scored three in a row herself, including two just two minutes apart to put the Terps ahead 5-2.
But turnovers were hurting Maryland in the first half as well. They had three turnovers within a five-minute period that turned into two goals by Boston College. A free position goal from Lauren Frankenfield with 10 minutes left in the half forced a 5-5 tie at halftime.
Maryland was struggling to create succinct plays to score, but their defense was helping them. Maryland goalkeeper Meg Taylor only had three saves in the first 15 minutes, but they were enough to keep the game level and gave the team some confidence going into the second half.
Taylor had nine saves in the second half but it was also helpful for the Terps that they got off to a very hot start in the second half. Maryland came out swinging and scored five straight goals to build a 10-5 lead. The first goal mirrored the start of the game, with Megan Whittle scoring just 20 seconds into the second stanza. Steele then scored back-to-back goals to raise her tally to five for the game. She also assisted Jen Giles' first goal of the game soon after. Giles added another goal to complete the run.
While Ochoa started the game and the top-scoring Terps offense only scored five goals in the first half, Boston College decided to make a goalie change at halftime and went with Lauren Daly. But after the five-goal Maryland run, they made the move back to Ochoa.
And with her in goal, Boston College worked on a comeback with a goal from Kate Weeks, which was assisted by Kent. Kent then went on to make a run in front of the goal and sent a shot low past Taylor.
After three shot attempts and a five-minute possession, Kent added her second straight goal to cut Boston College's deficit down to only two. With possession and momentum, they had a chance to make it a one-goal game, but the Eagles turned the ball over. Lizzie Colson scooped up the ball, Maryland went on a fast-break and Whittle scored to end an eight-minute scoring drought and put the Terps back up by three goals. That really proved to be crucial because even though the Eagles could get back within one goal, they were never able to tie the game in the second half.
Apuzzo scored two more times in the final three minutes to up her total for the year to 80 goals and helped set a new Division I women's championship game record with a combined 29 goals, but the Terps were able to run out the clock late to complete their incredible 23-0 championship season.


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Soros-backed enviro group sues Trump Administration (again), GOP Congressman Brian Mast suddenly goes silent
The Center for Biological Diversity, a group funded by liberal mega-donor George Soros, filed yet another lawsuit yesterday against President Donald Trump's administration, which they proudly boast brings the total number of lawsuits filed against the president or his administration to 136. The group's latest lawsuit names the U.S. Army Corps of Engineers, U.S. Fish and Wildlife Service and National Marine Fisheries Service as defendants and asks the court to halt discharges that the Army Corps says are necessary to prevent Lake Okeechobee from reaching dangerous levels.
In preemptively lowering Lake Okeechobee, the Army Corps says its primary goal is human safety, seeking to avert a Hurricane Katrina type of disaster that would put South Florida under significant flooding in the event of a failure of the Herbert Hoover Dike.
But environmental activists, including the Soros group, working with Republican Congressman Brian Mast, have been vocal in their opposition to the discharges, complaining about algae blooms caused by the nutrient-rich fresh water flowing into coastal estuaries. The groups, long courted by Mast, have supported his controversial plan to release water from Lake Okeechobee to extreme low levels that experts say would require water usage restrictions for millions of residents in South Florida.
Officials in West Palm Beach and a citizens group have come out strongly against the proposal by the Center for Biological Diversity and Mast, according a recent story in the Palm Beach Post:
Debate over Lake Okeechobee water levels is raising the hackles of city officials and a new group led by a former Florida House contender that is concerned a lower lake will leave West Palm Beach high and dry during drought.
Flyers distributed in West Palm Beach this past weekend by the South Florida Water Coalition refer to the 2011 drought where the lake dropped so low the city was forced to buy water from the county, public fountains were shut off and a glass of water at a restaurant was a special request.
Mast's office did not respond to a request to comment for this story, but his ties to the the Soros-backed Center for Biological Diversity are deep. He's appeared at several events hosted by the group, and social media posts show him posing with the group's senior attorney, Jaclyn Lopez and another liberal environmental activist.


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HomeQuick_newsSri Lankan president congratulates Murali on 800-wicket Test haul
Sri Lankan president congratulates Murali on 800-wicket Test haul
By Keira Daley
The President of Sri Lanka, HE Mahinda Rajapaksa, has today congratulated Muttiah Muralitharan on becoming the first bowler in history to take 800 wickets in Test cricket, as he retired from the game today. The Sri Lankan began the match against India, his 133rd Test, having taken 792 career Test wickets. Effective bowling forced the visitors side to follow on and Muralitharan's haul included Indian legend Sachin Tendulkar, taking him to 800 wickets in his Test career.
"Sri Lanka is proud of this son of our soil, who has reached the greatest height as a bowler with his new record, winning the highest respect of his contemporaries in the game the world over," said Rajapaksa, congratulating Murali on his world record.
Muli, as he is affectionately known, a Tamil by birth, has also taken 515 wickets in 337 one-day internationals, and a further 13 in Twenty20 internationals. His controversial bowling style has added to his international reputation leading to many comments on his unique bent-arm action.
Away from the international game, he has had spells with English counties Kent and Lancashire, and also starred for Chennai Super Kings in the lucrative Indian Premier League – taking 1-17 from his four overs as Chennai won this year's IPL final.
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I've been aware of Trilogy as a brand for some time, but mostly in relation to the Rosehip Oil which has won many awards – and yet I hadn't tried any Trilogy products until now.
The Trilogy Refresh & Shine Shampoo contains Keracyn™ which protects your hair by coating the hair shaft with a restorative botanical shield. It contains Calendula which brightens as it rinses away excess oil and product build up. It also contains marshmallow for shine, rosehip for condition and chamomile to sooth the scalp and make hair more manageable.
I've been trying to find the perfect shampoo for quite a while. I'm not sure if this is the one but it does do a great job at making my hair feel squeaky clean and it certainly feels as if it removes product build up. This is something that I've had to address more as I've started to experiment with more hair products such as heat protection spray.
Truth be told it's really a conditioner or hair mask that that I've been looking for. So I was looking forward to seeing what the overall effect would be when I used Trilogy Refresh and Shine Conditioner following on from using the Trilogy shampoo. It claims to effectively de-tangle your hair by smoothing hair cuticles, leaving your hair easy to manage and style. It contains Keracyn™ too as well as artichoke extract to protect your hair from sun and oxidisation damage; aloe vera for intense hydration and to preserve shine. It also contains rosehip and chamomile.
Did it wow me and give me the amazing texture and shine I was looking for? Well no, but it gave it a very good shot! My hair was definitely shiny and fragrant smelling but I still needed to use oil to make my hair feel weighty and glossy. To be fair I think that I need a treatment to kind of put my hair into rehab! These are great every day products for normal hair that hasn't been overheated and stressed.
Do you love Trilogy products? What have you tried?
This post contains affiliate links. The products were gifted for review but the opinions are my own and not prescribed.
Haha! That's true! I'm using them now so they're on the side of the bath in full view. I suppose I'm just saying that I wouldn't be drawn to them!


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Tag Archives: Ministry Of Health
Ten Countries With The Best Response To Covid 19
"The virus is cleverer than us, the virus is running faster than us." Dr. Li Ailan
The one thing that the countries that seem to be doing better at controlling the virus have in common is that their governments, healthcare, and science are working together. Early action, testing, and contact tracing were key steps in controlling the virus. It is a very different approach than the countries with leaders who are using the crisis to accelerate their authoritarianism by blaming the "others", demonizing journalists, and blanketing their countries in "I will never leave" darkness. Here are some countries in order from most to least cases with success stories. The numbers are from December 26.
Denmark 151,167 cases 1,153 deaths
Denmark's response to the pandemic was "act fast and act with force." Denmark is a peninsula and only shares one border with Germany. It was still one of the first country's to close its border and have a national lockdown. Denmark immediately banned large public gatherings, closed down all unnecessary venues across its cities, heavily discouraged the use of public transportation and all manner of travel unless absolutely essential. Daycares, schools, and universities were very quickly shut down and air travel was severely restricted. Their entire free health care system was able to prioritize and reorganize medical departments, isolation wards, and hospital beds, as well as doctors and nurses, to be optimally prepared to isolate and treat admitted patients. The Danish people have complete trust in their government and politicians. There were no conspiracy theories or widespread panic surrounding the virus. They acted responsibly and followed the rules.
Singapore 58,519 cases 29 deaths
Timely preparation, aggressive testing, tracing of carriers helped limit the impact of Covid-19 in Singapore. The city-state's comparatively small population of 5.7 million people and experience of SARS in 2003 gave it the upper hand against the encroaching virus. The government tightened border controls almost immediately after the disease first erupted in China – while also providing a clear public communication strategy.
South Korea 56,872 cases 808 deaths
The government of South Korea has been able to keep the disease under control without paralyzing the national health and economic systems. The critical factors in South Korea's public health administration and management that led to success include national infectious disease plans, collaboration with the private sector, stringent contact tracing, an adaptive health care system, and government-driven communication.
Australia 28,308 cases 908 deaths
Australia put their faith in science to get the pandemic under control. They formed a National Cabinet comprised of the leaders of each state and territory and the Prime Minister to resolve differences and put the necessary restrictions in place. National cooperation was further enhanced by working with the Australian Health Protection Principal Committee. In March they closed their borders and issued a two-week quarantine. Australians were quick to comply.
Uruguay 16,218 cases 147 deaths
Less than two weeks into his new job as Uruguay's president, Luis Lacalle Pou acted promptly when Uruguay's first case of covid-19 was confirmed in the capital of Montevideo on March thirteenth. Unlike most Latin American presidents, Lacalle Pou shut down schools and businesses but asked rather than ordered people to stay at home to protect the population, the oldest in Latin America. Subsidies for small businesses were financed in part by a reduction of politician and executive-level public servants' salaries, as well as by contributions made by business and social organizations. The swift action of the government slowed the spread of the virus and bought the country vital time to prepare its hospitals and testing system, says the team of scientists advising it. It also meant they could stop the virus's spread before it became exponential as it did in the hardest-hit nations. The alignment of decision-makers, scientists, and national health authorities was perfect and clearly with great timing," says Gonzalo Moratorio, a virologist directing Uruguay's covid-19 testing unit. Early testing and contact tracing were key. The strategy of appealing to citizens' sense of responsibility with measured restrictions has proven successful.
Iceland 5,683 cases 28 deaths
Although it is a small country with a population of 360,000 people, Iceland emerged as one of the leaders in controlling the virus. They immediately had a regiment of testing. contact-tracing and isolation, as well as genetic sequencing of the virus. On a per-capita basis, no country has done more testing They started screening in January a month before the first case arrived for high-risk people and anyone else who wanted to test. They took samples of the virus from every person infected to check for mutations. The widespread screening helped them pick out asymptomatic people who might have been spreading the virus.
New Zealand 2,144 cases 25 deaths
New Zealand started in February 2020 to identify cases and chains of transmission of the virus before it infected vulnerable populations. They did widespread testing, contact tracing, isolating infected cases, and quarantined their contacts. New Zealand has strict border control policies for produce and plants and immediately implemented them for people as well. They had a very stringent five-week lockdown in March. Rapid, science-based risk assessment linked to early, decisive government action was the difference between New Zealand and the countries where the virus spreads out of control.
Viet Nam 1,440 cases 35 deaths
Viet Nam shares a border with China and moved quickly. With the help of the World Health Organization, Viet Nam already had an emergency health plan in place. They had 16 cases in February and imposed a three-week quarantine in those places. There were no more cases. In March a case came in from the UK. They closed the borders. Both the military and local governments were mobilized to provide testing, meals, and amenity services to all and quarantine facilities which remained free during this period. There was never a nationwide lockdown, people were advised to stay home and some restrictive physical distancing measures were implemented throughout the country. Masks were mandatory. The Vietnamese public had been exceptionally compliant with government directives and advice, partly as a result of trust built up thanks to real-time, transparent communication from the Ministry of Health, supported by the WHO and other UN agencies. A COVID-19 song was released, with lyrics raising public awareness of the disease, which later went viral on social media with a dance challenge on Tik Tok initiated by Quang Dang, a local celebrity. (I love this)
Taiwan 783 cases 7 deaths
Taiwan was hit badly with SARS in 2003 and so as soon as a few cases of Covid 19 were identified in January, they were wearing masks. They had a public health response mechanism already in place to respond to the next pandemic. Taiwan has a world-class health system with universal coverage which moved quickly to respond to the threat. They immediately implemented a travel ban to China. Medical officials held daily public briefings with instructions to prevent the spread of the virus. They were able to stop the spread of Covid 19 without a lockdown because they started in January when the Western World did not.
Cambodia 363 case 0 deaths
In the first few months, Cambodia detected and managed 122 cases and avoided widespread community-level transmission. With the support of WHO and partners, Cambodia has made important investments over the last ten years in its health security system that allowed it to successfully respond to the initial outbreak of COVID-19. A whole-of-government and whole-of-society approach, along with vigilant surveillance, laboratory, rapid response teams, and good collaboration between the Ministry of Health and technical partners have all contributed to Cambodia's successful response. They are better prepared for the second wave than they were ten months ago but like everywhere people have pandemic fatigue and need to work.
Today alone Los Angeles recorded 30,000 new cases and 150 new deaths. I am so angry right now. Nations as poor as Cambodia and Viet Nam moved quickly and listened to the science and health care professionals and the greatest country in the world did not. All this death could have been avoided.
Please stay safe,
Posted in Health, travel, World Affairs	Tagged Australia, Australian Health Protection Principal Committee, border control, Cambodia, contact tracing, Covid-19, Denmark, genetic sequencing, Gonzalo Moratorio, healthcare, isolation, lockdown, Luis Lacalle Pou, Masks, Ministry Of Health, National Cabinet, preparation, Quang Dang, reponsibility, SARS, Singapore, South Korea, Taiwan, testing, Tik Tok, travel ban, UN, Uruguay, World Health Organization	3 Replies


text:
Regulation of TNF-α expression in normal macrophages: The role of C/EBPβ
Richard Pope*, Shubangee Mungre, Hongtao Liu, Bayar Thimmapaya
Medicine, Rheumatology Division
Microbiology-Immunology
C/EBPβ is present in monocytes and macrophages, binds to the proximal region of the TNF-α promoter, and contributes to its regulation. This study was performed to characterize the ability of C/EBPβ to regulate the TNF-α gene in myelomonocytic cells and primary macrophages. In transient transfection assays, overexpression of wild type C/EBPβ resulted in a 3-4-fold activation of a 120 base pair TNF-α promoter-reporter construct, while overexpression of a dominant negative (DN) C/EBPβ inhibited LPS-induced activation. In vitro monocyte-differentiated macrophages, infected with an adenoviral vector expressing the DN C/EBPβ (AdDNC/EBPβ) or the control Adβgal, expressed their transgenes weakly, however expression was greatly enhanced in the presence of PMA. Infection with AdDNC/EBPβ resulted in 60% suppression of LPS induced TNFα secretion compared to Adβgal infection (P < 0.001) in PMA-treated macrophages. Northern blot analysis demonstrated approximately a 40% reduction of the TNF-α mRNA in the presence of the DN C/EBPβ, suggesting that the effect of the DN C/EBPβ was at the transcriptional level. In contrast, AdDNC/EBPβ infection did not result in inhibition of LPS-induced TNF-α secretion in the absence of PMA. Further, DN versions of both C/EBPβ and c-Jun, but not NF-κB p65, suppressed PMA-induced TNF-α secretion in macrophages. These observations demonstrate that, C/EBPβ and c-Jun contribute to the regulation of the TNF-α gene in normal macrophages following treatment with PMA. (C) 2000 Academic Press.
https://doi.org/10.1006/cyto.2000.0691
C/EBPβ
10.1006/cyto.2000.0691
Dive into the research topics of 'Regulation of TNF-α expression in normal macrophages: The role of C/EBPβ'. Together they form a unique fingerprint.
Tumor Necrosis Factor Veterinary Science and Veterinary Medicine 100%
Macrophage Medicine and Dentistry 19%
macrophages INIS 19%
Secretion (Process) Medicine and Dentistry 8%
Infection Medicine and Dentistry 8%
Adenovirus Vector Medicine and Dentistry 8%
Regulatory Mechanism Medicine and Dentistry 8%
regulations INIS 8%
Pope, R., Mungre, S., Liu, H., & Thimmapaya, B. (2000). Regulation of TNF-α expression in normal macrophages: The role of C/EBPβ. Cytokine, 12(8), 1171-1181. https://doi.org/10.1006/cyto.2000.0691
Pope, Richard ; Mungre, Shubangee ; Liu, Hongtao et al. / Regulation of TNF-α expression in normal macrophages : The role of C/EBPβ. In: Cytokine. 2000 ; Vol. 12, No. 8. pp. 1171-1181.
@article{56c5a4697f014e839ca6a8aaf088dc88,
title = "Regulation of TNF-α expression in normal macrophages: The role of C/EBPβ",
abstract = "C/EBPβ is present in monocytes and macrophages, binds to the proximal region of the TNF-α promoter, and contributes to its regulation. This study was performed to characterize the ability of C/EBPβ to regulate the TNF-α gene in myelomonocytic cells and primary macrophages. In transient transfection assays, overexpression of wild type C/EBPβ resulted in a 3-4-fold activation of a 120 base pair TNF-α promoter-reporter construct, while overexpression of a dominant negative (DN) C/EBPβ inhibited LPS-induced activation. In vitro monocyte-differentiated macrophages, infected with an adenoviral vector expressing the DN C/EBPβ (AdDNC/EBPβ) or the control Adβgal, expressed their transgenes weakly, however expression was greatly enhanced in the presence of PMA. Infection with AdDNC/EBPβ resulted in 60% suppression of LPS induced TNFα secretion compared to Adβgal infection (P < 0.001) in PMA-treated macrophages. Northern blot analysis demonstrated approximately a 40% reduction of the TNF-α mRNA in the presence of the DN C/EBPβ, suggesting that the effect of the DN C/EBPβ was at the transcriptional level. In contrast, AdDNC/EBPβ infection did not result in inhibition of LPS-induced TNF-α secretion in the absence of PMA. Further, DN versions of both C/EBPβ and c-Jun, but not NF-κB p65, suppressed PMA-induced TNF-α secretion in macrophages. These observations demonstrate that, C/EBPβ and c-Jun contribute to the regulation of the TNF-α gene in normal macrophages following treatment with PMA. (C) 2000 Academic Press.",
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note = "Funding Information: This work was supported in part by an NIH grant (ROI AR43642), and by an NIH Multipurpose Arthritis and Musculoskeletal Diseases Center grant (P60 AR30692). We thank Harris Perlman and Constantinos Georganas for careful review of the manuscript.",
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Pope, R, Mungre, S, Liu, H & Thimmapaya, B 2000, 'Regulation of TNF-α expression in normal macrophages: The role of C/EBPβ', Cytokine, vol. 12, no. 8, pp. 1171-1181. https://doi.org/10.1006/cyto.2000.0691
Regulation of TNF-α expression in normal macrophages : The role of C/EBPβ. / Pope, Richard; Mungre, Shubangee; Liu, Hongtao et al.
In: Cytokine, Vol. 12, No. 8, 08.2000, p. 1171-1181.
T1 - Regulation of TNF-α expression in normal macrophages
T2 - The role of C/EBPβ
AU - Pope, Richard
AU - Mungre, Shubangee
AU - Liu, Hongtao
AU - Thimmapaya, Bayar
N1 - Funding Information: This work was supported in part by an NIH grant (ROI AR43642), and by an NIH Multipurpose Arthritis and Musculoskeletal Diseases Center grant (P60 AR30692). We thank Harris Perlman and Constantinos Georganas for careful review of the manuscript.
N2 - C/EBPβ is present in monocytes and macrophages, binds to the proximal region of the TNF-α promoter, and contributes to its regulation. This study was performed to characterize the ability of C/EBPβ to regulate the TNF-α gene in myelomonocytic cells and primary macrophages. In transient transfection assays, overexpression of wild type C/EBPβ resulted in a 3-4-fold activation of a 120 base pair TNF-α promoter-reporter construct, while overexpression of a dominant negative (DN) C/EBPβ inhibited LPS-induced activation. In vitro monocyte-differentiated macrophages, infected with an adenoviral vector expressing the DN C/EBPβ (AdDNC/EBPβ) or the control Adβgal, expressed their transgenes weakly, however expression was greatly enhanced in the presence of PMA. Infection with AdDNC/EBPβ resulted in 60% suppression of LPS induced TNFα secretion compared to Adβgal infection (P < 0.001) in PMA-treated macrophages. Northern blot analysis demonstrated approximately a 40% reduction of the TNF-α mRNA in the presence of the DN C/EBPβ, suggesting that the effect of the DN C/EBPβ was at the transcriptional level. In contrast, AdDNC/EBPβ infection did not result in inhibition of LPS-induced TNF-α secretion in the absence of PMA. Further, DN versions of both C/EBPβ and c-Jun, but not NF-κB p65, suppressed PMA-induced TNF-α secretion in macrophages. These observations demonstrate that, C/EBPβ and c-Jun contribute to the regulation of the TNF-α gene in normal macrophages following treatment with PMA. (C) 2000 Academic Press.
AB - C/EBPβ is present in monocytes and macrophages, binds to the proximal region of the TNF-α promoter, and contributes to its regulation. This study was performed to characterize the ability of C/EBPβ to regulate the TNF-α gene in myelomonocytic cells and primary macrophages. In transient transfection assays, overexpression of wild type C/EBPβ resulted in a 3-4-fold activation of a 120 base pair TNF-α promoter-reporter construct, while overexpression of a dominant negative (DN) C/EBPβ inhibited LPS-induced activation. In vitro monocyte-differentiated macrophages, infected with an adenoviral vector expressing the DN C/EBPβ (AdDNC/EBPβ) or the control Adβgal, expressed their transgenes weakly, however expression was greatly enhanced in the presence of PMA. Infection with AdDNC/EBPβ resulted in 60% suppression of LPS induced TNFα secretion compared to Adβgal infection (P < 0.001) in PMA-treated macrophages. Northern blot analysis demonstrated approximately a 40% reduction of the TNF-α mRNA in the presence of the DN C/EBPβ, suggesting that the effect of the DN C/EBPβ was at the transcriptional level. In contrast, AdDNC/EBPβ infection did not result in inhibition of LPS-induced TNF-α secretion in the absence of PMA. Further, DN versions of both C/EBPβ and c-Jun, but not NF-κB p65, suppressed PMA-induced TNF-α secretion in macrophages. These observations demonstrate that, C/EBPβ and c-Jun contribute to the regulation of the TNF-α gene in normal macrophages following treatment with PMA. (C) 2000 Academic Press.
KW - C/EBPβ
KW - LPS
KW - Macrophages
KW - PMA
KW - TNF-α
U2 - 10.1006/cyto.2000.0691
DO - 10.1006/cyto.2000.0691
JO - Cytokine
JF - Cytokine
Pope R, Mungre S, Liu H, Thimmapaya B. Regulation of TNF-α expression in normal macrophages: The role of C/EBPβ. Cytokine. 2000 Aug;12(8):1171-1181. doi: 10.1006/cyto.2000.0691


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