Today the FDA approved a new drug—one of few available—for treating liver cancer. Regorafenib is a pill manufactured by Bayer and sold as Stivarga. Already it's been approved for use in some patients with refractory colon, rectal and GI stromal tumors.
While I think this generally good news for affected patients, my enthusiasm is tempered by the poor response rate, and by its toxicity. The FDA based its approval on results from a randomized trial of 573 patients with progressive hepatocellular (liver) cancer.
As reported by the FDA, overall survival for liver cancer patients receiving Stivarga was 10.6 months, as opposed to 7.8 months with placebo. I wouldn't dismiss that small difference, of 3 months, if the disease were more tempered by this drug in more of the patients who tried it. But progression-free survival (PFS) was only 3.1 months for those liver cancer patients taking Stivarga, vs. 1.5 months with placebo—an almost negligible difference. Meanwhile, side effects were serious and common, as described, including pain, rashes, fatigue, nausea, diarrhea, liver failure, hypertension and other cardiovascular problems, infection, you name it.
Liver cancer represents an increasingly common tumor in the U.S. and around the globe. The incidence of liver cancer has more than tripled since 1980, the ACS reports. The disease tends to strike in late middle age, but affects people in all generations, of all races, and men more than women. Chronic inflammation due to hepatitis B or C is implicated as a cause in many but not all cases. The IARC reports that liver cancer is the second most common cause of cancer deaths worldwide; around 750,000 people receive a diagnosis each year, and it's usually lethal.
According to the NCI's website today, fewer than 80% of patients reach the five-year survival mark. (I suspect that statistic, from 2009, is outdated, but the point remains.) There's a desperate need for better ways to treat liver cancer, but this drug doesn't approach the level of improvement that should be available soon.
This drug (Regorafenib, BAY-73-4506) is said by investigators at Bayer to be a broad inhibitor of cellular enzymes (proteins, called kinases). Unlike precision medicines, which at least in principle are designed to match a single or few molecular targets, this agent is not specific in its activity; it can affect many signals in cancerous and healthy cells. That is probably why it's comparatively toxic.
Of interest, you can buy a one-month supply of this drug for around $5,500, which is lower than the cost of most new anti-cancer agents (typically $12,000 per month for pills). Stivarga may cost less because doctors and patients have had bad experiences in terms of toxicity and treatment failures. Surely Bayer can do better than this.


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Africa Uncensored: The Journalists Exposing Corruption in Kenya | Media
December 2, 2019 - by decent
"Our goal is to show Africa as it really is: The good, the bad, the ugly, the potential," says John Allan Namu, an investigative journalist in Nairobi, Kenya.
He co-founded Africa Uncensored, an investigative journalism collective that works to hold the government accountable and cover stories often unreported by the media.
They are working on a massive story: The government is believed to have misappropriated millions of dollars after Kenya's health minister signed a multimillion-dollar deal in 2015 for what he said was much-needed hospital equipment. The government also promised to invest in the improvement of Kenya's medical services, which were seen to be especially failing the poor.
Namu had received a tip-off from a source, leading him onto the case.
"The data set that we received showed us that there are corrupt networks in many, many places. But the place we chose to focus our attention on was on the ministry of health because this is one of the president's key pillars for delivery to the public," he says.
"And it seems as if it's either has been hijacked or it was formulated to steal from this country."
They carry out their investigation, using hidden cameras to confront an official, despite fears of reprisal.
Meanwhile, they feel the urgency to publish as they speak to those most affected by failures in the health system, including a mother who could not afford her cancer treatment.
Still, the team maintains their faith in the power of journalism.
"I think that the key role of journalism is that we publish the things that some people don't want published, even if that means that we are scared. Because at the moment that citizens have the information that they require to live their lives, that's when positive change happens," Namu says.
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Q: How do the pairs complex conjugate embeddings extend in the semi-direct product of Galois groups? Let $K$ be a finite Galois extension of $\mathbb{Q}$ which is not totally real and let $(\sigma_1, \overline{\sigma_1}), \ldots, (\sigma_l, \overline{\sigma_l})$ be the pairs of complex conjugate embeddings of $K$ into $\mathbb{C}$. Let $L/K$ be a finite Galois extension such that $L/\mathbb{Q}$ is Galois and
$$Gal(L/\mathbb{Q}) \cong Gal(L/K) \rtimes Gal(K/\mathbb{Q}),$$
where $\rtimes$ stands for semi-direct product.
Let the $g_1, g_2, \ldots, g_n$ be the elements of $Gal(L/K)$.
Under the above conditions, I would like to know if the pairs of complex conjugate embeddings of $L$ into $\mathbb{C}$ are given by $(g_j\sigma_i, g_j\overline{\sigma_i})$ (with $1 \leq j \leq n$, $1\leq i \leq l$). If this is true, what would be a way to prove it? If the statement does not hold, can we say anything about how the complex conjugate pairs are related via the semidirect product?
Many thanks.

A: No, not necessarily. Consider $ K = \mathbf Q(\zeta_3) $, $ L = \mathbf Q(\sqrt[3]{2}, \zeta_3) $. We have that $ \textrm{Gal}(L/\mathbf Q) \cong S_3 $, which is the semidirect product of $ C_3 $ and $ C_2 $, so the desired condition is satisfied. Now, let $ \sigma $ be a $ 3 $-cycle and $ \tau $ be complex conjugation. The embeddings given by $ \sigma \tau $ and $ \sigma \bar{\tau} = \sigma $ are not conjugate: we have
$$ \sigma \tau (\sqrt[3]{2}) = \zeta_3 \sqrt[3]{2} $$
$$ \sigma(\sqrt[3]{2}) = \zeta_3 \sqrt[3]{2} $$
whereas $ \bar{\sigma}(\sqrt[3]{2}) = \tau \sigma(\sqrt[3]{2}) = \zeta_3^2 \sqrt[3]{2} $. Essentially, the desired condition breaks down because $ S_3 $ is not abelian.
However, it is obviously true that complex conjugate embeddings are given by $ (\sigma_i g_j, \bar{\sigma_i} g_j) $, since function composition is associative.

redpajama_set_name: RedPajamaStackExchange


First Nations want to be among those cashing in on what could become a multibillion-dollar industry if the federal government follows through on making marijuana a legal recreational drug in Canada.
The Trudeau government's goal is to make legalization a reality on or before July 1, 2018. Several First Nations are already trying to get into into the business of producing pot.
"It means economic opportunities for First Nations people … and so many First Nations across this country are in such dire straits," said Allan Adam, chief of the Athabasca Chipewyan First Nation, a fly-in community in northern Alberta.
Allan said his community is exploring investing in a company that's already producing medical marijuana — as a start. If recreational marijuana is legalized, he said, the First Nation will already have its foot in the door.
The marijuana industry could be a 'win-win' for both Canada and impoverished First Nations, said Chief Allan Adam. (CBC)"Until it becomes recreational, we have to invest in medical."
Other First Nations have gone beyond exploring and have invested millions in cannabis ventures, like the Wahgoshig First Nation near Kirkland Lake, Ont., which partnered with an Ontario company called DelShen Therapeutics in 2015 to convert a former forestry operation into a facility that will grow "pharmaceutical-grade" pot.
Former Assembly of First Nations head Phil Fontaine also recently moved into the medical marijuana business with his company, Indigenous Roots.
"Our primary interest here, of course, is business opportunities, job creation. It's about the Indigenous economy, job opportunities, and it's about training," Fontaine told CBC News in December 2016.
The Mohawk Council of Kahnawake in Quebec announced in March that it was on a "fact-finding mission," seeking information about the medical cannabis industry. The community's website says the council now has a Cannabis Working Group.
In an email, political press attache Joe Delaronde said the council "has made no secret of its very preliminary exploration of potential business opportunities in the medical marijuana field."
The Mohawk Council of Kahnawake is just one First Nation that's investigating the benefits of investing in legal marijuana, medical and recreational. (CBC)In an appearance on Kahnawake Television, a local station, council Chief Rhonda Kirby said leadership was also investigating other possible opportunities.
"We are looking for partnerships with people that are already licensed providers, and in anticipation of the federal law being passed in 2018, what would that mean for the community if a recreational [marijuana] law was passed?"
At the Assembly of First Nations annual meeting in Gatineau, Que., in December 2016, chiefs unanimously supported a resolution introduced by Chief Adam, which directs the organization to push Ottawa for "priorities and incentives to ensure that First Nations are given the opportunity to participate and benefit fully from the development of this new and emerging sector."
One issue that's likely going to come up when First Nations invest in recreational marijuana, Adam admits, is the health aspect — especially in those communities that are already grappling with addiction issues.
While he's willing to make money off any new pot industry, Adam said there still needs to be discussion between Canada and Indigenous communities before legalization.
"You can't just impose something that's going to have detrimental effects on our communities," he said.
He wants to see money from the business of pot invested in programs in First Nations communities, especially those aimed at youth.
"It's a win-win situation for Canada and it's a win-win situation for First Nations."


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Presidium, Gurgaon, hosted a grand ceremony, THE CHAIRPERSON HONOURS (October 2016 Meet), with a lot of excitement and enthusiasm. At the meet, Mrs. Sudha Gupta, the honorable Chairperson of Presidium, congratulated more than 230 Presidians for their extraordinary achievements in academics, sports and co-curricular activities. Presidium believes in the power of acknowledgement; it not only builds confidence but also strengthens the students' determination to achieve more, steering them to a path set by great leaders and achievers. At the ceremony, parents of these young leaders relished every moment of this unforgettable experience, too.


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HomeDVD Reviews
The Vinyl Verdict!
By Brian Wise on	 February 28, 2016 DVD Reviews MUSIC NEWS
Review by Roy Trakin.
Vinyl (HBO)
Like the recent Diary of a Teenage Girl, Vinyl is poised at the moment the '60s era of peace-and-love curdled into the druggy, coke-fueled desperation of the '70s. As for its surprisingly numerous detractors – many of whom claim to have experienced its depictions first hand – this is not a documentary, but a feverish dream of a music business that never existed in real life, a parody that's supposed to be funny. And you won't find me complaining about a narrative that includes an epiphany at an expertly recreated New York Dolls concert at a crumbling Mercer Arts Center.
Bobby Cannavale is a mash-up of Tommy Mottola, Walter Yetnikoff and, yes, the late Marty Thau, whose own life was changed when he discovered the Dolls, giving up a cushy promotion gig with Neil Bogart (another possible role model) to pursue his rock 'n' roll dreams.
Like Terence Winter's Boardwalk Empire, another show that got off to a slow start before finding its stride, Vinyl liberally mixes reality and fiction– Hy Weiss' "$100 handshake," the take-off on MCA's "Music Cemetery of America" put-down, Led Zeppelin manager Peter Grant's legendary temper, mobsters-cum-promotion men like Joe Isgro and corrupt label boss Morris Levy.
Sure, the time frame is off just a little – and Marty Scorsese's presence turns it more into Goodfellas meets Hit Men, while fellow executive producer Mick Jagger casts a sneering, lookalike son who's a combination of his old man and Richard Hell.
Still, I'm enjoying the small touches – when the Germans refer to 'The Led Zeppelin," it reminds me of real-life Polygram label chief Guenter Hensler, who used to enthuse in his thick accent, "Kiss is fan-tas-tic."
Sure, there's exaggerated melodrama – the crushing of Andrew Dice Clay's gun-wielding Spector-esque radio guy's head is more mafia than music biz — but that has always been part of its allure.
Vinyl airs in Australia on Showcase, Mondays at 8.30pm (repeated during the week).
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Antoine-François-Claude Ferrand (* 4. Juli 1751 in Paris; † 17. Januar 1825 ebenda) war ein französischer Politiker, Historiker und Mitglied der Académie française.

Leben
Graf Ferrand entstammte einer auf die absolute Monarchie eingeschworenen Adelsfamilie. Bereits mit 18 Jahren wurde er erblich Richter im Parlement de Paris. Der von Maupeou 1771 versuchten Reform des Parlements widersetzte er sich, wie viele seiner Kollegen, und wurde verbannt, 1774 von Ludwig XVI. aber zurückberufen. Nach Ausbruch der Revolution ging er schon 1789 in die Emigration und kämpfte in Condés Rheinarmee. Nach deren Auflösung kehrte er 1801 nach Frankreich zurück, blieb aber unter Napoleon politisch inaktiv.

Den Sturz Napoleons begrüßte er. Ludwig XVIII. machte ihn 1814 zum Staatsminister. 1815 wurde er Pair von Frankreich und 1816 vom König zum Mitglied der Académie française (Sitz Nr. 28) ernannt. Er starb 1825 im Alter von 73 Jahren.

Aus dem Exil begleitete Ferrand die Revolutionsereignisse bis 1795 mit zahlreichen polemischen Schriften. Zurück in Frankreich legte er 1802 eine vierbändige Geschichtsphilosophie vor, die sechs Auflagen erlebte. 1817 fügte er eine ebenfalls vierbändige Revolutionstheorie hinzu, 1820 eine dreibändige Geschichte der Teilungen Polens. Postum erschienen noch sein politisches Testament (1830) und Memoiren (1897). Daneben hatte er 1814 eine Biographie der Madame Élisabeth publiziert, die 1861 neu aufgelegt wurde. Seit seiner Verbannung 1771 schrieb Ferrand Versdramen, die er 1817 gesammelt veröffentlichte, die aber offenbar nur im privaten Rahmen zur Aufführung kamen.

Werke (Auswahl)

Zeitgeschichte und Geschichtsphilosophie
 Le rétablissement de la monarchie française. Ohne Ort 1793. 2. Auflage. Lüttich 1794.
 Éloge funèbre de Mme Élisabeth, sœur de Louis XVI. Rottermundt, Regensburg 1795.
 Des causes qui ont empêché la contre-révolution en France, et considérations sur la révolution sociale; suivies d'une notice sur Robespierre et ses complices. Haller, Bern 1795.
 L'Esprit de l'histoire, ou Lettres politiques et morales d'un père a son fils, sur la manière d'étudier l'histoire en général, et particulièrement l'histoire de France. 4 Bde. Paris 1802. 4. Auflage. 1805. 6. Auflage. 1826.
 Éloge historique de Mme Élisabeth de France, suivi de plusieurs lettres de cette princesse. Desenne, Paris 1814. 1861.
 Théorie des révolutions rapprochée des principaux événements qui en ont été l'origine, le développement ou la suite. 4 Bde. Michaud, Paris 1817.
 Histoire des trois démembrements de la Pologne. 3 Bde. Deterville, Paris 1820. 1865.
 Testament politique. Dufart, Paris 1830.
 Mémoires du Comte Ferrand, ministre d'État sous Louis XVIII publiés, pour la Société d'histoire contemporaine, par le Vicomte de Broc. Picard, Paris 1897. (hrsg. von Hervé de Broc 1848–1916, mit Kurzbiographie)

Theater
 Philoctète. 1786. (Philoktetes, mit langem Vorwort)
 Œuvres dramatiques. Paris 1817. (Le siège de Rhodes. Zoari. Philoctète. Alfred)
 Les Conjurés napolitains, tragédie en 5 actes et en vers. Barba, Paris 1838.

Literatur
 Dictionnaire des parlementaires de 1789 à 1889. Bd. 2. Paris 1889, S. 628–629

Weblinks

 Personaleintrag des Senats, französisch

Autor
Neuzeithistoriker
Geschichtsphilosoph
Mitglied der Académie française
Französischer Emigrant
Staatsminister (Frankreich)
Graf (Frankreich)
Mitglied der Pairskammer (Restauration)
Mitglied der Ehrenlegion (Kommandeur)
Bühnenautor
Franzose
Geboren 1751
Gestorben 1825
Mann

redpajama_set_name: RedPajamaWikipedia


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Братя Райт – Орвил и Уилбър, са американски пионери в авиацията.

Велосипедни механици, на 17 декември 1903 г. те извършват първия в историята на човечеството контролиран полет с моторен летателен апарат по-тежък от въздуха.

Изпитанието е извършено с моторен летателен апарат "Флайер I", който, пилотиран от Орвил, се задържа във въздуха 12 секунди и изминава разстоянието от 37 метра. На следващия ден Уилбър прави второ изпитание, като този път самолетът остава в небето 59 секунди, а изминатият път е 250 метра.

Всичко обаче започва 7 години по-рано, когато братята научават за смъртта на немския изобретател Ото Лилиентал, който загива по време на полет с разработения от него планер.

Братята вече имат работилница, в която продават, поправят и произвеждат велосипеди, което им осигурява средства за изследвания в областта на въздухоплаването.

Още през 1899 г. Уилбър и Орвил започват опити с хвърчила и безмоторни самолети. Следващата година вече са готови с безмоторен самолет в пълен мащаб, достатъчно голям да носи човек.

Братята Райт успяват да разработят система за хоризонтално управление на полета с вертикална опашка, предно управляващо крило за височината и система за деформиране на крилото, която да балансира аеродинамичната устойчивост на полета. След това се концентрират в търсенето на подходящ двигател. Много време им отнема и намирането на точната форма за витлото на машината. Опитът за летене обаче не е от най-сполучливите.

През 1901 г. построяват и изпробват втори, а година по-късно и трети, за да се стигне до утрото на 17 декември 1903 година. В района на пясъчните дюни недалеч от градчето Кити Хоук, край брега на Атлантическия океан в Северна Каролина.

Аеропланът "Флайер" (по-късно ще бъде добавена и номерация и ще го наричат "Флайер I") полетява, управляван от Орвил. Машината има бензинов двигател с мощност 12-конски сили.

В продължение на две години след успешните полети те усъвършенстват конструкцията на аероплана, като с него извършват около 200 полета. По-късно те построяват втори и трети самолет, като непрекъснато променят двигателите им и по този начин подобряват летежа им.

През 1905 г. изминават разстоянието от 39 km за 38 минути и 3 секунди.

На 22 май 1906 г. братя Райт получават патент за своето изобретение. През 1909 г. създават компанията "Райт", която се занимава с производство на летателни апарати и обучение на пилоти.

Братя Райт са сред най-значимите личности на 20 век, допринесли изключително много за развитието на авиацията.

Източници

Пионери в авиацията

Авиоконструктори от САЩ
Американски изобретатели

Американски семейства по професия
Родени на 19 август
Родени на 16 април
Починали на 30 януари
Починали на 30 май


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Bee therapy: From venom to drug
Salonaz Sami, Tuesday 6 Dec 2022
Apitherapy, also known as Bee venom therapy or (BVT), is a type of alternative medicine that relies on the use of honeybee venom for the treatment of many medical conditions.
For thousands of years, people have used honeybee products as medicines, with their curative effects even being described in the Bible and the holy Quran.
The use of bee venom can be traced back to Ancient Egypt, Greece and China.
Hippocrates, the ancient Greek doctor, was known for using bee venom for its therapeutic qualities.
Recently, however, the use of honeybee venom for treating chronic or autoimmune diseases, has resurfaced.
The venom fights off inflammation and destruction of connective tissues and can return activity and mobility by supporting the body's natural defences.
"Bee venom, also known as Apitoxin, is produced by a tiny gland, located in the abdominal cavity of the bee, often to be used as a defence tool when feeling threatened," explained Hag Mohammed Safaan, who has been working in the beekeeping business for over 35 years.
"It is a transparent and odourless liquid that dries soon after coming into contact with air," Safaan further explained.
Safaan believes that although bee-derived toxins are used, in classical medicine, to treat chronic inflammatory disorders, pain and neurological disorders among other conditions, it could be more beneficial to use the venom directly from the source.
"In traditional bee sting therapy, the bees go directly to the target point, on the human body, and stings," he said.
The live bee is gently held with tweezers by the person administrating the venom then places it on the part of the patient's body to be treated for the bee to sting.
"Sadly, after stinging the human body the bee cannot pull back the stinger and parts of its digestive tract along with some muscles and nerves," Safaan explained.
This major abdominal rupture kills the bee, he said.
Ice is then used to numb the skin and reduce the pain.
"The idea is that bee stings cause inflammation, which leads to an anti-inflammatory response by the patient's immune system," Safaan explained.
"The stings are applied over the body on a rotating basis so that the former treated area is given the time to heal from the previous stings," he said.
"As long as the patient receiving the stings is not hyper-allergic, the treatment is safe without any long-term adverse effects," he added.
The patients usually receive three bee stings a week, every other day.
If a person has not been stung by a bee before, it's crucial to try a test sting before applying full stings to be sure they are not hyper-allergic.
"In a test sting, the honey bee stinger is scratched out within a split second after it has become embedded in the skin," he explained
"We wait 20-30 minutes to see if the patient suffers from any allergic symptoms, like loss of blood pressure, fainting or breaking out in hives all over the body," he further explained.
Interestingly, the best spots, on the human body, to apply BVT are the places that acupuncturists insert their needles.
"Stings applied to these points give greater results than when applied in other areas," he added.
As with any treatment, there are minor side effects that can be expected from BVT. The most common include swelling, redness, itching, soreness and feeling pain and heat in the stung area. However, the symptoms improve on their own within 48 hours as the chemicals from the venom are filtered out of the body.
"At the beginning, I questioned why would anyone ever choose willingly to be stung by a bee? It is very painful, it swells up and creates inflammation," wondered Omaima Tawfik, 46, a stay-at-home mom.
"I did my research and discovered that in larger amounts bee stings are very toxic and very irritating to your body, however, in very small amounts, I believe it is more of a hermetic effect where you give a small dosage of something and your body then responds by creating a stress which then adapts and strengthen your immune system," she explained.
Tawfik has battled multiple sclerosis for a while, a disease that causes the body's nerves to slowly deteriorate.
"I was not able to move without feelings of numbness and tingling and was always in terrible pain," she said. After using conventional medications for a while, she decided to turn to Safaan.
Every week, Safaan treats tens of patients and sacrifices hundreds of bees, but the results are amazing.
Tawfik began an intensive treatment course, receiving about 50 stings a week for months.
Although honey bees only sting once and die, the stinger continues to inject venom into its victim even after being separated from the bee.
"The pain of the stings could last for up to an hour," she said, describing the experience. After 6 months of BVT, Tawfik has seen a dramatic change. She insists the therapy has cured her multiple sclerosis and have given her a new chance at life without pain.
On one hand, her physician says her illness is simply in remission, but on the other hand, she believes that bee stings have helped her walk again. But, whether her recovery is in her head or her hands and feet, for the first time in more than a year Tawfik feels she can resume living. A therapy most of us consider taboo is allowing her to have a future with renewed hope and without pain.
In addition, honeybee venom reduces blood glucose level through increased insulin secretion and glucose take-up, thus, it is being considered as a potential remedy for diabetes. It also plays an important role in fighting skin wrinkles, and it is used in the cosmetics industry as an ant wrinkle agent.
Actress Gwyneth Paltrow recently spoke with the New York Times about BVT, saying she had tried it. "People use it to get rid of inflammation and scarring. It is actually pretty incredible if you research it. But man, it is painful."
Apitherapy
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Private Academic Tutoring
Private Test Prep
Advocacy + IEP and 504 Plan Consulting
Private College & Career Counseling
Small-Group Classes
We're excited to launch several Zoom classes this summer. Please sign up using the interest form link below. Most courses have a three student minimum and eight student maximum. In the future, we look forward to partnering with local businesses to provide in-person summer camps.
Sign Up Link for Summer Zoom Classes
All of these Zoom classes are 10 hours total; 2 hours per day over one week (Monday-Friday). We will offer these classes twice during the summer: the weeks of June 29-July 3 and July 27-31. These classes are designed for students who want to get ahead/preview the content for the upcoming school year. The full 10-hour class is $250 per student. Minimum of 3 students, maximum of 8 students per class.
Pre-Algebra will be 8:30-10:30 a.m. Monday through Friday. Offered the weeks of June 29 and July 27.
Algebra 1 will be 11 a.m.-1 p.m. Monday through Friday. Offered the weeks of June 29 and July 27.
Geometry will be 1:30- 3:30 p.m. Monday through Friday. Offered the weeks of June 29 and July 27.
The test prep classes are 16 hours total; four hours per week over four weeks. Each class is two hours long. The classes will dig into the essential content and strategies for success on the tests. They are designed for students who are just beginning to prepare for the ACT/SAT. The cost is $500 per student with a book included. Minimum of 3 students, maximum of 8 students per class. In addition, on Friday, July 31, we will proctor a full, timed practice test. The practice test for the ACT will be 9am-12:30pm, and the practice test for the SAT will be 1-4pm.
ACT Prep will be Monday/Wednesday 10 a.m.–12 p.m. starting July 13 and ending Aug. 5. Additionally, there will be a full proctored test on Friday, July 31, from 9 a.m.–12:30 p.m.
SAT Prep will be Tuesday/Thursday 10 a.m.–12 p.m. starting on July 14 and ending Aug. 6. Additionally, there will be a full proctored test on Friday, July 31, from 1–5pm.
Early Grades Reading for K-2: This two-week reading program (10 hours total) will include multi-sensory, differentiated, explicit, and systematic instruction in phonemic awareness, phonics, fluency, vocabulary, and comprehension strategies. There are many skills that are woven into skilled reading, and during these one-hour sessions, we will dig deeply into each of these components. Phonics instruction will be based on a pre-assessment. Students will gain an understanding of sounding out one-syllable words with both short and long vowel sounds. After completion of this program, students will gain decoding and comprehension strategies that they can use to help them become more confident and fluent readers.
Dates/Times: Monday through Friday from June 29 through July 10, 9–10 a.m.
Cost: The full 10-hour class is $250 per student
Reading Comprehension for rising grades 3-5: This two-week reading program (10 hours total) will help students develop reading comprehension skills. During our one-hour sessions, we will practice comprehension strategies and metacognitive skills; then, we will read passages together to apply what we've learned. After completion of this program, students will be able to identify and effectively apply comprehension strategies and will be able to identify the main idea and supporting details of a variety of texts.
Dates/Times: Monday through Friday beginning July 6 and ending July 17. Class will meet 9:30-10:30 a.m.
Active Reading Circle for rising grades 6-8: The middle school active reading circle will be an opportunity for students to engage with stories and short novels in a social setting. Much like a book club, questions are designed to spark various perspectives and interpretations of literature, as well as authentic conversation about authorial choice. Additionally, this course is designed to ensure that students are also equipped with strategies and tools that will be useful in the school setting next school year. This is a three hour weekly committment over three weeks. Classes are 1.5 hours and will meet Tuesday and Thursday afternoons for the three-week period. This 9-hour class is $225 per student.
Dates/Times:
This class will meet on the following dates: July 7, 9, 14, 16, 21, 23. Classes will start at 1:00 p.m. and end at 2:30 p.m.
Cost: This 9-hour class is $225 per student.
Active Reading Circle for rising grades 9-11: The high school school active reading circle will be an opportunity for students to engage with stories and short novels in group settings. Text sets are collected by a teacher to spark thematic discussion around universal questions, "how do people assimilate into various cultures?" or "What is civil disobedience?" Much like a book club, various perspectives and interpretations of literature are encouraged. Additionally, this course is designed to ensure that students are equipped with strategies and tools that will be useful in the school setting next school year. This is a four hour weekly committment over three weeks. Classes are 2 hours and will meet Tuesday and Thursday afternoons for the three-week period. This 12-hour class is $300 per student.
Creative Writing for rising grades 6-8: In the creative writing class for middle school, students will participate in generative writing prompts—short models or questions that encourage quick drafting on various topics, from nature, family, hobbies, or memory. Writers will have between five and twenty minutes to independently develop poetry, story, or song, and can then choose what to share for the audience. Peer feedback will focus on the positive aspects of work and teacher feedback will focus on strengthening mechanics and style. Classes last 1.5 hours and will meet Mondays and Fridays for two weeks. The class is a total of six hours over the two week period. This six-hour class is $150 per child.
This class will meet on the following Wednesdays and Fridays: July 8, 10, 15, 17. All classes will start at 1:00 p.m. and end at 2:30 p.m.
Cost: The full six-hour class is $150 per student.
Writers Workshop for rising grades 9-12: The writers workshop course for high school students takes the middle school creative writing class to the next level of sophistication. In the high school class, students will develop their voice and sharpen their writing mechanics. Students will participate in generative writing prompts—short models or questions that encourage quick drafting on various topics and themes, from nature, family, growing up, and overcoming challenges. Writers will have between five and twenty minutes to independently develop poetry, story, or song, and can then choose what to share for the audience. Peer to peer feedback will focus on positive aspects of writing, and students will also receive individualized teacher feedback on voice, style, development of characters or plot, and organization of content. Classes last two hours and will meet Wednesdays and Fridays for two weeks. The class is a total of eight hours over the two week period. This 8-hour class is $200 per student.
Mindfulness Learning Strategies: Social emotional learning is about understanding feelings, emotions, and making connections with peers and adults. This class will focus on what emotions are and how to identify emotions correctly in different situations. The classes will include opportunities for self-reflection on the emotions that each student faces at different times, as well as mindfulness exercises and strategies to use at home and at school. Each group will meet two times for one hour (2 hours total).
Dates/times based on age group:
Ages 6-8: June 29 and July 1, 4-5 p.m.
Ages 9-10: June 30 and July 2, 4-5 p.m.
Ages 11-12: June 30 and July 2, 2-3 pm
Cost: The 2-hour class is $55 per student
IEP Advocacy for Parents: This class is designed to help parents understand IEPs, their rights as a parent, and get support on next steps for their child, as well as tips on how to navigate IEP meetings, evaluations, academics, and behaviors.
Thursday, July 16, 3-5 p.m.
Wednesday, August 5, 7-9 p.m.
Cost: The two-hour advocacy class is $55.
Serving Nashville, Brentwood, Franklin, and Murfreesboro, Tennessee
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MD ANDERSON INPATIENT
MD - a Mid-Atlantic state; one of the original 13 colonies Free State, Maryland, Old Line State U.S.A., United States, United States of America, US, USA, America, the States, U.S. - North American republic containing 50 states - 48 conterminous states in North America plus Alaska in northwest North America and the Hawaiian Islands in the Pacific Ocean; achieved . Webplural MDs or M.D.s.: doctor of medicine. John Smith, MD. She earned an M.D. from Harvard Medical School. Members pay what they would for a standard, managed-care . WebM.D. students study throughout Washington, Wyoming, Alaska, Montana and Idaho for maximum experience across urban and rural environments.
Community MD Anderson Cancer Center - North, located on the Community Hospital North campus, is filled with hope, collaboration and easy navigation. 17 hours ago · Maryland delegates held a hearing to question the state's college savings plan leaders after families complained for months that they couldn't access all of the money in their accounts. The University of Texas MD Anderson Cancer Center is a comprehensive cancer center in of inpatient and out-patient management, using existing UT MD Anderson. The M. D. Anderson Cancer Center campus includes an inpatient pavilion with beds, five research buildings, three outpatient clinic buildings. WebMD: Major Depression: MD: Medical Department: MD: Mode (DSC) MD: Missing Data (statistics) MD: Mini Disc: MD: Master's Degree: MD: Marketing Director: MD: Management Division: MD: Mother's Day: MD: Managing Director: MD: Memorial Day: MD: Molecular Dynamics: MD: Moldova (ISO country identifier) MD: Mason-Dixon (Civil War era . MD Anderson will file your insurance claims for both your hospital and physician visits. If you are an inpatient, your hospital insurance claim will be filed. WebM.D. students study throughout Washington, Wyoming, Alaska, Montana and Idaho for maximum experience across urban and rural environments. Jan 17, · The Bel Air Athletic Club will close on Feb. 16 after providing fitness, social, educational and child care opportunities to the Bel Air community for over 40 years. The reason for the closing.
The Scripps MD Anderson Cancer Center on Genesee Avenue in San Diego serves people from across the region who need cancer treatment. MD - a Mid-Atlantic state; one of the original 13 colonies Free State, Maryland, Old Line State U.S.A., United States, United States of America, US, USA, America, the States, U.S. - North American republic containing 50 states - 48 conterminous states in North America plus Alaska in northwest North America and the Hawaiian Islands in the Pacific Ocean; achieved . WebThe leading source for trustworthy and timely health and medical news and information. Providing credible health information, supportive community, and educational services by blending award. Start a Business in Maryland. Boat Registration Information. Bay Bridge Information. Coronavirus Disease (COVID) Outbreak Information. COVID Vaccinations in Maryland. Business Filings and Registrations. Individual Income and Business Tax Payments. Business Sales & Use Tax Payments. Business Entity Search, Certificate of Status & Document Order. The University of Texas M.D. Anderson Cancer CenterRice Business - Jones Graduate Work with multiple stakeholders and leaders to advance the inpatient. There are more than inpatient beds, including laminar flow rooms and medical and surgical intensive care units. Each year there are more than 17, The University of Texas M.D. Anderson Cancer Center has expanded their inpatient capacity at Alkek Tower in the Medical Center. Floors 20, 21, and In addition to the hands-on experience in the operating room, clinic, and inpatient floor, the trainees are required to attend the educational activities of the.
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MD: Major Depression: MD: Medical Department: MD: Mode (DSC) MD: Missing Data (statistics) MD: Mini Disc: MD: Master's Degree: MD: Marketing Director: MD: Management Division: MD: Mother's Day: MD: Managing Director: MD: Memorial Day: MD: Molecular Dynamics: MD: Moldova (ISO country identifier) MD: Mason-Dixon (Civil War era boundary between . Texas Children's Hospital West Campus recently announced a $50 million capital improvement plan to expand inpatient capacity, ambulatory capacity and supporting. Scripps MD Anderson is part of MD Anderson Cancer Network, a global collaborative network of hospitals and health care systems dedicated to MD Anderson's. It excels in providing acute medical and surgical services as well as intensive care, inpatient/outpatient surgery, neurology, cancer care, urology, pulmonary. WebJan 17, · The Bel Air Athletic Club will close on Feb. 16 after providing fitness, social, educational and child care opportunities to the Bel Air community for over 40 years. The reason for the closing. Webplural MDs or M.D.s.: doctor of medicine. John Smith, MD. She earned an M.D. from Harvard Medical School. Members pay what they would for a standard, managed-care .
WebMD Abbreviation for: macular degeneration, see there magnesium deficiency maintenance dose malate dehydrogenase male treated with deoxycorticosterone malic dehydrogenase manic-depressive (now, bipolar disorder, see there) Mantoux diameter maternal deprivation medical department medical discharge medical doctor (medicinae doctor, see there) . There is an active MD Anderson Master Plan thread that will span the next 8-years on HAIF. The Master Plan "closes out" in plural MDs or M.D.s.: doctor of medicine. John Smith, MD. She earned an M.D. from Harvard Medical School. Members pay what they would for a standard, managed-care plan, and they . Just great. Inpatient Pharmacy Technician(Former Employee) - Houston, TX - January 7, Everyone was respectful, the work wasn'. This position prefer candidates with inpatient coding experience. Mission Statement The mission of The University of Texas M. D. Anderson Cancer. Pisters became medical director and eventually vice president for MD Anderson's regional care system, comprising multiple Houston-area locations. He previously.


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Board Elects New President, Officers
2023 MCFB Officers: Arin Rader, Treasurer; Darren Davis, Vice President; J.C. Zimmerman, Secretary; Brian Dirks, President
The McLean County Farm Bureau Board of Directors elected officers at the January board meeting.
Brian Dirks, President
Darren Davis, Vice President
Arin Rader, Treasurer
J.C. Zimmerman, Secretary
2022-23 Board Election Results
McLean County Farm Bureau member, Austin O'Neall of LeRoy, was elected to serve as a member
of the board of directors. John Burkhart of Stanford, Arin Rader of Normal, and Carly Rickard of
Heyworth, were each re-elected to the board. All board members are elected to three year terms
McLean County Farm Bureau would like to commend and thank Fred Grieder of Carlock for 21 years of service as a member of the board of directors including five years as Vice President and six years as President. Grieder completed his seventh term and will stepped down as of January 2023.
The board would also like to recognize and thank Mark Hines for his four years of service as McLean County Farm Bureau President. Hines remains a member of the board, but did not seek re-election to the office of President.


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sarah.briggs@ndm.ox.ac.uk
DPhil Student
Sarah joined HERC in September 2018 to complete her DPhil under the supervision of Sarah Wordsworth. She is developing a genetic and environmental risk model for colorectal cancer, and evaluating the clinical utility and cost effectiveness of using this model to stratify approaches to bowel cancer screening in the English Bowel Cancer Screening Programme by prior risk. She is using UK Biobank (genetic, epidemiological and hospital data) to develop her risk model, and a HERC model of bowel cancer screening (Murphy et al. 2017) to evaluate its impact.
Sarah graduated with BMBCh from the University of Oxford. She then undertook an Academic Foundation post at Kings College Hospital, London, followed by an Academic Clinical Fellowship in Medical Oncology in Oxford, researching inherited predisposition to colorectal cancer under the supervision of Professor Ian Tomlinson (now at the University of Birmingham). She subsequently worked as a Medical Oncology registrar before beginning her DPhil studies.
DPhil title
Development and Assessment of a Genetic and Environmental Risk Model for Colorectal Cancer
Dr Sarah Wordsworth (HERC, Nuffield Department of Population Health)
Dr James East (Experimental Medicine, Nufield Department of Medicine)
Professor Julia Hippisley-Cox (Nuffield Department of Primary Care Health Sciences)
Professor Ian Tomlinson (University of Birmingham)
COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study.
Lee LYW. et al, (2020), Lancet Oncol, 21, 1309 - 1316
Evaluating the Integration of Genomics into Cancer Screening Programmes: Challenges and Opportunities
Briggs S. and Slade I., (2019), Current Genetic Medicine Reports, 7, 63 - 74
Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Law PJ. et al, (2019), Nat Commun, 10
Pattern recognition receptor polymorphisms as predictors of oxaliplatin benefit in colorectal cancer
CHURCH DN. et al, (2018), JNCI: Journal of the National Cancer Institute
Somatic POLE proofreading domain mutation, immune response and prognosis in colorectal cancer: a retrospective, pooled biomarker study
Domingo E. et al, (2016), Lancet Gastroenterology and Hepatology


I applied for VAT remowal almost two weeks ago. I sent to OVH support copies of my business name registration (I am sole trader with Registered Business Name) as well as Revenue VAT confirmation form . Surprisingly today I received email which states my company is not the registered organistion of the VAT number provided.
Is this a joke? How can I prove that I am not a camel. Revenue documents are not important for OVH, also VIES webpage says the same What now!
What is your customer ID/Order Number?
Are you inside of the EU? If so, it's more probable you should pay VAT, except under some rules I don't remember very well. Also, what about using your name for the request?
I do not recommend using OVH for any real business, you will be disappointed sooner or later!


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Taylor Swift Releases "Lover" Music Video
Taylor Swift has released the music video for "Lover," her third single and the title track off of her seventh studio album 'Lover.'
By Katherine Schaffstall
Katherine Schaffstall
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Taylor Swift on Thursday released the music video for the title track off of her upcoming album Lover.
The romantic ballad features a booming snare drum and piano as she sings to her lover. The song opens with Swift singing about her and her partner leaving the Christmas lights up into January, followed by the line, "Have I known you 20 seconds or 20 years?"
To chronicle the love story detailed in the tune, the music video opens with a little girl unwrapping a snowglobe Christmas gift. Soon entering the world of the snowglobe, fans get to see Swift portray a love story with dancer-musician Christian Owens. The video narrates the couple's life at home, showing them embrace while laying on the couch, eating dinner, having a party with friends, etc., all the while Swift serenades her "lover" with the song on her guitar.
In the YouTube live stream, Swift described the video as being "aesthetically pleasing from a color standpoint." The concept of the snowglobe derived from a "You Are in Love" song lyric, a song off her 1989 album. The song lyric reads: "And so it goes, you two are dancing in a snowglobe, round and round."
Swift praised her "heroic" co-star Owens, who was one of her dancers on her Reputation stadium tour last year. "Every single night I could see how expressive he was," she said. Apart from Owens being a dancer, Swift shared that he is also a musician to which "every record label is going to be fighting for him." She also added: "He's your new best friend. Your new favorite artist."
Swift released the song on Aug. 16 with a lyric video that features short clips from home videos. Before the release of the tune and lyric video, Swift teased on Twitter that the music video would drop after her YouTube Livestream. During the Livestream, Swift took the stage in front of a small audience and shared some details about the upcoming album, answered fan questions, performed her new song "The Archer,'" showed a behind-the-scenes look at her album cover photoshoot and offered a glimpse at her fashion collaboration with Stella McCartney.
"Lover" is the third song off of Swift's seventh studio album to have a music video. She first released the single "ME!" featuring Panic! at the Disco's Brendon Urie in April. The upbeat song was accompanied by a colorful music video that featured a number of hints about the album.
The anti-hate anthem "You Need to Calm Down" was the second single. The music video, which was released in June, features a star-studded cast including Billy Porter, Laverne Cox, Ellen DeGeneres, Ryan Reynolds, RuPaul Charles, Jesse Tyler Ferguson, Ciara, Katy Perry and the cast of Queer Eye.
Swift later released the promotional track "The Archer" in July ahead of the album's release date, which is Friday.
Watch the music video for "Lover" below.
Taylor Swift Reveals Why She Decided to Publicly Advocate for LGBTQ Rights
Lusia Harris, First Woman Drafted by NBA and Subject of 'The Queen of Basketball,' Dies at 66
Kaepernick Publishing to Release Autobiography of NBA Star Who Protested Anthem by Praying
New Sandman Universe Comic to Be Written by James Tynion IV (Exclusive)
Beijing Winter Olympics Will Offer Tickets to "Selected Groups" of Spectators
Colombian Author Gabriel Garcia Marquez Had Secret Mexican Daughter


Kitchen design is not an easy task. Every detail must be considered to the finest detail. An error may have resulted in a out. Such problems do not want to fight, you can choose the easy way with the model of a kitchen. Must not engage in random selections as well. Ready-made model of many firms producing in the market. Of course, the best of these companies and the future is best first to mind. The company is very elegant, beautiful and high quality productions for many years is launching the most popular models. Now our future is in the production of ready-made kitchen with a series of Regina will present examples. These models are good choices to make from the kitchen.


Doom 3 is one of my all time favourite video games of all time, I believe it to be a masterpiece with the level design and plot, as well as the gameplay all combining together to create the feeling that you really are on the doomed Mars UAC (Union Aerospace Corporation) facility surviving a Hell invasion. With Doom Id have gone back to their roots which many people felt Doom 3 strayed too far from, due to this knowledge I didn't have high hopes it would outclass the third game.
It seems that new Doom doesn't follow on from Doom, Doom II, or Doom 3 (if not for the game taking place at a similar time to the third one I feel it could have easily included that one as canon). You play as a nameless man known as Doom Marine who at the games start is freed from an ancient stone sarcophagus. The UAC had found a gateway to Hell, instead of doing what normal people would do and closing it up they instead decided to explore it and in doing so discovered a cheap and powerful energy source called Argent (as well as the resting place of the Doom Marine). The whole base is occupied with both finding new ways to use the limitless energy, as well as performing experiments on captured demons in hopes of making them into controllable biological weapons. However head researcher Olivia Pierce goes rogue and opens a Hell portal that summons in a demonic army who soon kill all on the base. You have been revived by the base's head of operations; the cyborg Samuel Hayden, who along with a powerful A.I called VEGA help you on your journey to close the portal to Hell, as well as stop Olivia.
Doom is a mix up of both the old and new style of Doom games, initially it shared far more in common with the previous game than I could have ever hoped, there is plenty of story while the UAC base feels like a proper location rather than a series of random levels (this time around there are levels rather than interconnecting areas, thirteen in all naturally). Most of these levels feature a similar layout, there will be corridors with exploration, then more larger open areas where you will be required to kill all demons before being able to continue on. Levels start off with more of the exploration side than fighting, there are plenty of secret areas to discover as well as power-ups to find, coolest secrets are rooms which unlock original Doom levels. Later into the game once the majority of demon types are shown it turns far more into a original Doom style game with oodles of frantic intense battles, levels design turns far more old school.
You have access to all the classic weapons including the plasma rifle, chain gun and fan favourite the almighty powerful BFG. All your main weapons have two different special modes that points can be used to upgrade, the shotgun for instance is either able to fire an explosive round, or fire three rounds at once. The BFG and chainsaw are limited to special slots so can only be used a few times before limited ammo is needed to be able to use them again. When you have dealt enough damage to enemies they get staggered and glow orange, these can then be glory killed in a variety of crazy ways, each enemy type has several different death animations with eyes being burst, throats cut and all sort of limbs being ripped off, these are all uber violent and fun to do only taking a second or two as well as providing you with additional health. You also get abilities in the form of runes that assist you in various ways such as making demons stagger quicker and making your boost jump more controllable.
All the classic Doom enemies are here, given updated looks and abilities, you have the zombie grunts who really are no issue at all, imps now clamber around walls and leap about all over the place. The Mancubus, Hell Knights, Cacodemon etc are all what you have known before and pretty much act like you would expect with some fun new twists. There doesn't seem to be any Doom II enemy types but there are a lot of enemies here with not really any copies. Throughout the campaign there are a few boss battles, none of these really gave me any problems but they were a fun change up to the usual gameplay. Graphically this looks great close up, I did notice some of the level backgrounds in the outdoor areas were really quite bland and flat looking, while the mix of industrial areas and rocky ones meant there wasn't a lot of variation. Music is all rock based and while it is very suitable for the carnage unfolding on screen it is not a patch on the original games (something that becomes especially apparent when playing one of the classic maps).
The campaign is around ten hours in length on a first playthrough, much shorter I imagine replaying it with souped up weapons and having no need to search for secrets would probably halve that time. The plot is ok, not a patch on three but I did appreciate that there was plot even if fighting through a Mars base post-invasion was not as exciting or engaging as in Doom 3 where you were fighting during the initial invasion. There are echoes that show you a ghostly flashback to the invasion but these are pretty limp looking and underwhelming. The UAC levels are much better designed than the levels set in Hell, I was a bit disappointed in the Hell levels overall, not very inventive in their look, also as a game this is not scary, far too action packed to create any sense of fear at all.
In addition to the main campaign there is a cool level editor, I never tried making a level myself (apparently it is quite easy) but there are already hundreds of fan made levels up that I had a load of fun trying out, I expect to revisit this in the future as these levels can only improve, they even feature weaponry not available in the main game. Classic levels once unlocked can be selected from the main screen, these feature the music and level graphics of the original but weirdly you, your weapons, and the enemies are all in the new Doom style, a weird mash up but as I own the original Doom in many versions I did not mind this. Id made much noise about their deathmatch mode, I tried it in Beta and wasn't impressed so didn't even try it in the finished game. From what I hear it is very bland trying to appeal to the Call of Duty crowd and failing quite hard. It is a shame all the DLC planned for this game is only going to be deathmatch levels and no single player content.
This game is a healthy does of dumb fun that does at times get a little bit tiring, I loved that the campaign was so long and that it wasn't a complete throwback to the games of old, however it certainly isn't a patch on the one before this (not that I expected it to be). The weapons have real punch to them, the enemies real fun to battle and overall I was pleased with it, even with the level editor though I can tell this unlike three is never going to be up there with my favourite games.


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Justia Regulation Tracker Agencies And Commissions Securities And Exchange Commission Self-Regulatory Organizations; NASDAQ BX, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Increase the BX Options Market Port Fees and Institute a Fee Cap at Chapter XV Section 3, 11381-11383 [2017-03461]
Self-Regulatory Organizations; NASDAQ BX, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Increase the BX Options Market Port Fees and Institute a Fee Cap at Chapter XV Section 3, 11381-11383 [2017-03461]
Download as PDF Federal Register / Vol. 82, No. 34 / Wednesday, February 22, 2017 / Notices post all comments on the Commission's Internet Web site (http://www.sec.gov/ rules/sro.shtml). Copies of the submission, all subsequent amendments, all written statements with respect to the proposal that are filed with the Commission, and all written communications relating to the proposal between the Commission and any person, other than those that may be withheld from the public in accordance with the provisions of 5 U.S.C. 552, will be available for Web site viewing and printing in the Commission's Public Reference Room, 100 F Street NE., Washington, DC 20549, on official business days between the hours of 10:00 a.m. and 3:00 p.m. Copies of such filings also will be available for inspection and copying at the principal office of the Exchanges. All comments received will be posted without change; the Commission does not edit personal identifying information from submissions. You should submit only information that you wish to make available publicly. All submissions should refer to File Number SR– NYSEMKT–2016–99 and should be submitted on or before March 15, 2017. Rebuttal comments should be submitted by March 29, 2017. For the Commission, by the Division of Trading and Markets, pursuant to delegated authority.19 Eduardo A. Aleman, Assistant Secretary. [FR Doc. 2017–03398 Filed 2–21–17; 8:45 am] BILLING CODE 8011–01–P [Release No. 34–80055; File No. SR–BX– 2017–009] Self-Regulatory Organizations; NASDAQ BX, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Increase the BX Options Market Port Fees and Institute a Fee Cap at Chapter XV Section 3 sradovich on DSK3GMQ082PROD with NOTICES February 16, 2017. Pursuant to Section 19(b)(1) of the Securities Exchange Act of 1934 (''Act''),1 and Rule 19b–4 thereunder,2 notice is hereby given that on February 8, 2017, NASDAQ BX, Inc. (''BX'' or ''Exchange'') filed with the Securities and Exchange Commission (''SEC'' or ''Commission'') the proposed rule change as described in Items I, II, and III below, which Items have been prepared by the Exchange. The CFR 200.30–3(a)(57). U.S.C. 78s(b)(1). 2 17 CFR 240.19b–4. 1 15 VerDate Sep<11>2014 16:05 Feb 21, 2017 Jkt 241001 I. Self-Regulatory Organization's Statement of the Terms of Substance of the Proposed Rule Change The Exchange proposes to increase the BX Options Market port fees and institute a fee cap at Chapter XV Section 3. The text of the proposed rule change is available on the Exchange's Web site at http://nasdaqbx.cchwallstreet.com/, at the principal office of the Exchange, and at the Commission's Public Reference Room. II. Self-Regulatory Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change In its filing with the Commission, the Exchange included statements concerning the purpose of and basis for the proposed rule change and discussed any comments it received on the proposed rule change. The text of these statements may be examined at the places specified in Item IV below. The Exchange has prepared summaries, set forth in sections A, B, and C below, of the most significant aspects of such statements. A. Self-Regulatory Organization's Statement of the Purpose of, and Statutory Basis for, the Proposed Rule Change 1. Purpose SECURITIES AND EXCHANGE COMMISSION 19 17 Commission is publishing this notice to solicit comments on the proposed rule change from interested persons. The purpose of the proposed rule change is to increase the BX Options Market port fees and institute a fee cap at Chapter XV Section 3(b).3 The Exchange notes that it has not increased fees for the connectivity provided under the rule since its adoption in January 2015 4 notwithstanding that the costs that the Exchange incurs in offering the connectivity have increased. As described below, the Exchange is also proposing to limit the total amount that an Options Participant 5 may be assessed under the rule. Under the Chapter XV Section 3(b), the Exchange assesses an Options Participant $200 per port, per month, 3 The Exchange initially filed the proposed pricing changes on February 1, 2017 (SR–BX–2017– 005). On February 8, 2017, the Exchange withdrew that filing and submitted this filing. 4 See Securities Exchange Act Release No. 73894 (December 19, 2014), 79 FR 78119 (December 29, 2014) (SR–BX–2014–060). 5 As defined by BX Options Rules Chapter II, Section 1. PO 00000 Frm 00046 Fmt 4703 Sfmt 4703 11381 per mnemonic 6 for Order Entry Ports,7 CTI Ports,8 BX Depth Ports,9 BX TOP Ports,10 and Order Entry DROP Ports 11 without a cap on how much a Participant is assessed.12 The Exchange is proposing to increase the fee assessed for Order Entry Ports, CTI Ports, BX Depth Ports, BX TOP Ports, and Order Entry DROP Ports to $650 per port, per month, per mnemonic, which is consistent with the fees assessed by The NASDAQ Stock Market for comparable connectivity.13 The Exchange is also 6 A ''mnemonic'' is a unique identifier consisting of a four character alpha code. 7 The Order Entry Port Fee is a connectivity fee in connection with routing orders to the Exchange via an external order entry port. BX Options Market Participants access the Exchange's network through order entry ports. A BX Options Market Participant may have more than one order entry port. 8 CTI offers real-time clearing trade updates. A real-time clearing trade update is a message that is sent to a member after an execution has occurred and contains trade details. The message containing the trade details is also simultaneously sent to The Options Clearing Corporation. The trade messages are routed to a member's connection containing certain information. The administrative and market event messages include, but are not limited to: System event messages to communicate operational-related events; options directory messages to relay basic option symbol and contract information for options traded on the Exchange; complex strategy messages to relay information for those strategies traded on the Exchange; trading action messages to inform market participants when a specific option or strategy is halted or released for trading on the Exchange; and an indicator which distinguishes electronic and non-electronically delivered orders. 9 A BX Depth Port provides access to BX Depth, which is a data feed that provides quotation information for individual orders on the BX book, last sale information for trades executed on BX, and Order Imbalance Information as set forth in BX Options Rules Chapter VI, Section 8. BX Depth is the options equivalent of the BX TotalView/ITCH data feed that BX offers under BX Rule 7023 with respect to equities traded on BX. As with TotalView, members use BX Depth to ''build'' their view of the BX book by adding individual orders that appear on the feed, and subtracting individual orders that are executed. See Chapter VI, Section 1(a)(3)(A). 10 BX TOP Port is a data feed that provides the BX Best Bid and Offer (''BBO'') and last sale information for trades executed on BX. The BBO and last sale information are identical to the information that BX sends to the Options Price Regulatory Authority (''OPRA'') and which OPRA disseminates via the consolidated data feed for options. BX TOP Port is the options equivalent of the BX Basic data feed offered for equities under BX Rule 7047. See Chapter VI, Section 1(a)(3)(B). 11 The DROP interface provides real time information regarding orders sent to the BX Options Market and executions that occurred on the BX Options Market. The DROP interface is not a trading interface and does not accept order messages. 12 The Exchange also assesses a $500 SQF Port fee, which is assessed per port, per month. A SQF Port is a port that allows a Participant acting as options Market Maker to enter its markets into the BX Options Market. The Exchange is not proposing to amend the fees assessed for SQF Ports or apply the proposed limit on fees to SQF Port fees. 13 See NASDAQ Options Rules Chapter XV, Section 3(b). E:\FR\FM\22FEN1.SGM 22FEN1 11382 Federal Register / Vol. 82, No. 34 / Wednesday, February 22, 2017 / Notices sradovich on DSK3GMQ082PROD with NOTICES proposing to limit the amount a Participant must pay for the aforementioned connectivity provided under Chapter XV Section 3(b) to $7,500 per month. 2. Statutory Basis The Exchange believes that its proposal is consistent with Section 6(b) of the Act,14 in general, and furthers the objectives of Sections 6(b)(4) and 6(b)(5) of the Act,15 in particular, in that it provides for the equitable allocation of reasonable dues, fees and other charges among members and issuers and other persons using any facility, and is not designed to permit unfair discrimination between customers, issuers, brokers, or dealers. The Exchange believes that increasing the fee assessed for Order Entry Ports, CTI Ports, BX Depth Ports, BX TOP Ports, and Order Entry DROP Ports to $650 per port, per month, per mnemonic is reasonable because it is competitive with the fees of other exchanges. Specifically, The NASDAQ Stock Market assesses $650 per port, per month, per mnemonic for comparable connectivity under Nasdaq Options Market Rules Chapter XV, Section 3(b). Moreover, the Exchange notes that it has not increased fees for the connectivity provided under the rule since it adopted the connectivity options on January 2, 2015,16 notwithstanding that costs associated with offering and supporting the connectivity have increased, which include the cost of technology and infrastructure. The costs that the Exchange incurs is substantially similar to those that The NASDAQ Stock Market incurs, since both exchanges use the same hardware and support services for the ports. Thus, the Exchange has determined that $650 per port, per month, per mnemonic is the appropriate fee that will allow it to cover its costs and realize a profit, while avoiding an overall reduction in the number of subscribers. The Exchange also believes that the proposed $7,500 fee cap is reasonable because, taken together with the proposed fee increase, it will allow the Exchange to cover costs while reducing the impact of the fees on Options Participants that subscribe to a large number of ports. Because Options Participants generally need an increasing number of ports as provided under BX Options Market Rules Chapter XV Section 3(b) as their activity expands on the BX Options Market, the Exchange believes that without such a cap Options Participants may be 14 15 U.S.C. 78f(b). U.S.C. 78f(b)(4) and (5). 16 See note 4, supra. inhibited from growing their activity on the Exchange. As a general principal, the Exchange believes that greater participation on the BX Options Market by Options Participants improves market quality for all market participants. Thus, in arriving at a fee cap of $7,500, the Exchange balanced the desire to improve market quality against the need to cover costs and make a profit. The Exchange believes that increasing the fee assessed for Order Entry Ports, CTI Ports, BX Depth Ports, BX TOP Ports, and Order Entry DROP Ports to $650 per port, per month, per mnemonic is an equitable allocation and is not unfairly discriminatory because the increased fee will apply to all Options Participants that have, or are seeking, the connectivity provided under the rule. As noted above, the Exchange is increasing the fees under the rule to align them with the costs associated with offering the ports as well as to allow the Exchange to realize a profit. The Exchange believes that the proposed $7,500 fee cap is an equitable allocation and is not unfairly discriminatory because the any Options Participant that subscribes to connectivity under the rule that would otherwise exceed $7,500 per month will have its fees capped. Although Options Participants that do not have fees under the rule in excess of $7,500 per month will not benefit from the fee cap, the Exchange notes that any Options Participant may increase the number of ports subscribed to receive the fee cap, should their activity on the BX Options Market warrant increased subscription. Moreover, Options Participants that do not qualify for the fee cap will benefit from the greater liquidity provided by Options Participants that conduct a sufficient level of activity on the BX Options Market to require connectivity in excess of the fee cap. The Exchange notes that it is not amending or applying a fee limitation to SQF Port Fees, which are also provided under BX Options Market Rules Chapter XV Section 3(b).17 The Exchange believes that it is equitable and not unfairly discriminatory to increase the other port fees, as proposed herein, and not increase the fee assessed for SQF Port Fees because SQF Port Fees are used by BX market makers in connection with their market making activities. Unlike other Options Participants, BX market makers add value to the market through continuous quoting and a commitment of capital. The Exchange believes that not applying a limitation on fees to SQF Port Fees is 15 15 VerDate Sep<11>2014 16:05 Feb 21, 2017 17 See Jkt 241001 PO 00000 note 12, supra. Frm 00047 Fmt 4703 Sfmt 4703 equitable and not unfairly discriminatory because the Exchange has found that maintaining the separation between SQF ports and the other ports under BX Options Market Rules Chapter XV Section 3(b) is appropriate given the different purposes for subscribing to the ports. Moreover, the Exchange does not believe that applying an independent fee limitation to SQF Port Fees is warranted at this juncture because of the limited number of SQF ports to which any single market maker subscribes. B. Self-Regulatory Organization's Statement on Burden on Competition The Exchange does not believe that the proposed rule change will impose any burden on competition not necessary or appropriate in furtherance of the purposes of the Act. In terms of inter-market competition, the Exchange notes that it operates in a highly competitive market in which market participants can readily favor competing venues if they deem fee levels at a particular venue to be excessive, or rebate opportunities available at other venues to be more favorable. In such an environment, the Exchange must continually adjust its fees to remain competitive with other exchanges and with alternative trading systems that have been exempted from compliance with the statutory standards applicable to exchanges. Because competitors are free to modify their own fees in response, and because market participants may readily adjust their order routing practices, the Exchange believes that the degree to which fee changes in this market may impose any burden on competition is extremely limited. In this instance, the proposed changes to the charges assessed for Order Entry Ports, CTI Ports, BX Depth Ports, BX TOP Ports, and Order Entry DROP Ports under BX Options Market Rules Chapter XV Section 3(b) do not impose a burden on competition because the Exchange's connectivity services are completely voluntary and subject to extensive competition both from other exchanges and from off-exchange venues. To the extent that the changes are viewed unfavorably by Options Participants, the proposed fees increase and fee cap may result in the Exchange losing subscribership and market participation, which would likely benefit other exchanges and trading venues. Accordingly, the Exchange does not believe that the proposed changes will impair the ability of Options Participants or competing order execution venues to maintain their E:\FR\FM\22FEN1.SGM 22FEN1 Federal Register / Vol. 82, No. 34 / Wednesday, February 22, 2017 / Notices competitive standing in the financial markets. C. Self-Regulatory Organization's Statement on Comments on the Proposed Rule Change Received From Members, Participants, or Others No written comments were either solicited or received. III. Date of Effectiveness of the Proposed Rule Change and Timing for Commission Action The foregoing rule change has become effective pursuant to Section 19(b)(3)(A)(ii) of the Act.18 At any time within 60 days of the filing of the proposed rule change, the Commission summarily may temporarily suspend such rule change if it appears to the Commission that such action is: (i) Necessary or appropriate in the public interest; (ii) for the protection of investors; or (iii) otherwise in furtherance of the purposes of the Act. If the Commission takes such action, the Commission shall institute proceedings to determine whether the proposed rule should be approved or disapproved. IV. Solicitation of Comments Interested persons are invited to submit written data, views, and arguments concerning the foregoing, including whether the proposed rule change is consistent with the Act. Comments may be submitted by any of the following methods: sradovich on DSK3GMQ082PROD with NOTICES Electronic Comments • Use the Commission's Internet comment form (http://www.sec.gov/ rules/sro.shtml); or • Send an email to rulecomments@sec.gov. Please include File Number SR–BX–2017–009 on the subject line. Paper Comments • Send paper comments in triplicate to Secretary, Securities and Exchange Commission, 100 F Street NE., Washington, DC 20549–1090. All submissions should refer to File Number SR–BX–2017–009. This file number should be included on the subject line if email is used. To help the Commission process and review your comments more efficiently, please use only one method. The Commission will post all comments on the Commission's Internet Web site (http://www.sec.gov/ rules/sro.shtml). Copies of the submission, all subsequent amendments, all written statements with respect to the proposed rule change that are filed with the 18 15 U.S.C. 78s(b)(3)(A)(ii). VerDate Sep<11>2014 16:05 Feb 21, 2017 Commission, and all written communications relating to the proposed rule change between the Commission and any person, other than those that may be withheld from the public in accordance with the provisions of 5 U.S.C. 552, will be available for Web site viewing and printing in the Commission's Public Reference Room, 100 F Street NE., Washington, DC 20549 on official business days between the hours of 10:00 a.m. and 3:00 p.m. Copies of the filing also will be available for inspection and copying at the principal office of the Exchange. All comments received will be posted without change; the Commission does not edit personal identifying information from submissions. You should submit only information that you wish to make available publicly. All submissions should refer to File Number SR–BX– 2017–009, and should be submitted on or before March 15, 2017. For the Commission, by the Division of Trading and Markets, pursuant to delegated authority.19 Eduardo A. Aleman, Assistant Secretary. [FR Doc. 2017–03461 Filed 2–21–17; 8:45 am] BILLING CODE 8011–01–P SECURITIES AND EXCHANGE COMMISSION Proposed Collection; Comment Request Upon Written Request, Copies Available From: Securities and Exchange Commission, Office of FOIA Services, 100 F Street NE., Washington, DC 20549–2736. Extension: Form N–8B–4; SEC File No. 270–180, OMB Control No. 3235–0247. Notice is hereby given that, pursuant to the Paperwork Reduction Act of 1995 (44 U.S.C. 3501 et seq.), the Securities and Exchange Commission (''Commission'') is soliciting comments on the collection of information summarized below. The Commission plans to submit this existing collection of information to the Office of Management and Budget (''OMB'') for extension and approval. Form N–8B–4 (17 CFR 274.14) is the form used by face-amount certificate companies to comply with the filing and disclosure requirements imposed by Section 8(b) of the Investment Company Act of 1940 (15 U.S.C. 80a–8(b)). Among other items, Form N–8B–4 requires disclosure of the following information 19 17 Jkt 241001 PO 00000 CFR 200.30–3(a)(12). Frm 00048 Fmt 4703 Sfmt 4703 11383 about the face-amount certificate company: Date and form of organization; controlling persons; current business and contemplated changes to the company's business; investment, borrowing, and lending policies, as well as other fundamental policies; securities issued by the company; investment adviser; depositaries; management personnel; compensation paid to directors, officers, and certain employees; and financial statements. The Commission uses the information provided in the collection of information to determine compliance with Section 8(b) of the Investment Company Act of 1940. Form N–8B–4 and the burden of compliance have not changed since the last approval. Each registrant files Form N–8B–4 for its initial filing and does not file post-effective amendments to Form N–8B–4.1 Commission staff estimates that no respondents will file Form N– 8B–4 each year. There are currently only four existing face-amount certificate companies, and none have filed a Form N–8B–4 in many years. No new faceamount certificate companies have been established since the last OMB information collection approval for this form, which occurred in 2014. Accordingly, the staff estimates that, each year, no face-amount certificate companies will file Form N–8B–4, and that the total burden for the information collection is zero hours. Although Commission staff estimates that there is no hour burden associated with Form N–8B–4, the staff is requesting a burden of one hour for administrative purposes. Estimates of the burden hours are made solely for the purposes of the PRA and are not derived from a comprehensive or even a representative survey or study of the costs of SEC rules and forms. The information provided on Form N–8B–4 is mandatory. The information provided on Form N–8B–4 will not be kept confidential. An agency may not conduct or sponsor, and a person is not required to respond to, a collection of information unless it displays a currently valid OMB control number. Written comments are invited on: (a) Whether the proposed collection of information is necessary for the proper performance of the functions of the agency, including whether the information will have practical utility; 1 Pursuant to Section 30(b)(1) of the Act, each respondent keeps its registration statement current through the filing of periodic reports as required by Section 13 of the Securities Exchange Act of 1934 and the rules thereunder. Post-effective amendments are filed with the Commission on the face-amount certificate company's Form S–1. Hence, respondents only file Form N–8B–4 for their initial registration statement and not for posteffective amendments. E:\FR\FM\22FEN1.SGM 22FEN1
[Federal Register Volume 82, Number 34 (Wednesday, February 22, 2017)]
[Release No. 34-80055; File No. SR-BX-2017-009]
Self-Regulatory Organizations; NASDAQ BX, Inc.; Notice of Filing
and Immediate Effectiveness of Proposed Rule Change To Increase the BX
Options Market Port Fees and Institute a Fee Cap at Chapter XV Section
February 16, 2017.
(``Act''),\1\ and Rule 19b-4 thereunder,\2\ notice is hereby given that
on February 8, 2017, NASDAQ BX, Inc. (``BX'' or ``Exchange'') filed
with the Securities and Exchange Commission (``SEC'' or ``Commission'')
the proposed rule change as described in Items I, II, and III below,
which Items have been prepared by the Exchange. The Commission is
publishing this notice to solicit comments on the proposed rule change
from interested persons.
The Exchange proposes to increase the BX Options Market port fees
and institute a fee cap at Chapter XV Section 3.
The text of the proposed rule change is available on the Exchange's
Web site at http://nasdaqbx.cchwallstreet.com/, at the principal office
of the Exchange, and at the Commission's Public Reference Room.
concerning the purpose of and basis for the proposed rule change and
Item IV below. The Exchange has prepared summaries, set forth in
sections A, B, and C below, of the most significant aspects of such
statements.
The purpose of the proposed rule change is to increase the BX
3(b).\3\ The Exchange notes that it has not increased fees for the
connectivity provided under the rule since its adoption in January 2015
\4\ notwithstanding that the costs that the Exchange incurs in offering
the connectivity have increased. As described below, the Exchange is
also proposing to limit the total amount that an Options Participant
\5\ may be assessed under the rule.
\3\ The Exchange initially filed the proposed pricing changes on
February 1, 2017 (SR-BX-2017-005). On February 8, 2017, the Exchange
withdrew that filing and submitted this filing.
\4\ See Securities Exchange Act Release No. 73894 (December 19,
2014), 79 FR 78119 (December 29, 2014) (SR-BX-2014-060).
\5\ As defined by BX Options Rules Chapter II, Section 1.
Under the Chapter XV Section 3(b), the Exchange assesses an Options
Participant $200 per port, per month, per mnemonic \6\ for Order Entry
Ports,\7\ CTI Ports,\8\ BX Depth Ports,\9\ BX TOP Ports,\10\ and Order
Entry DROP Ports \11\ without a cap on how much a Participant is
assessed.\12\ The Exchange is proposing to increase the fee assessed
for Order Entry Ports, CTI Ports, BX Depth Ports, BX TOP Ports, and
Order Entry DROP Ports to $650 per port, per month, per mnemonic, which
is consistent with the fees assessed by The NASDAQ Stock Market for
comparable connectivity.\13\ The Exchange is also
proposing to limit the amount a Participant must pay for the
aforementioned connectivity provided under Chapter XV Section 3(b) to
$7,500 per month.
\6\ A ``mnemonic'' is a unique identifier consisting of a four
character alpha code.
\7\ The Order Entry Port Fee is a connectivity fee in connection
with routing orders to the Exchange via an external order entry
port. BX Options Market Participants access the Exchange's network
through order entry ports. A BX Options Market Participant may have
more than one order entry port.
\8\ CTI offers real-time clearing trade updates. A real-time
clearing trade update is a message that is sent to a member after an
execution has occurred and contains trade details. The message
containing the trade details is also simultaneously sent to The
Options Clearing Corporation. The trade messages are routed to a
member's connection containing certain information. The
administrative and market event messages include, but are not
limited to: System event messages to communicate operational-related
events; options directory messages to relay basic option symbol and
contract information for options traded on the Exchange; complex
strategy messages to relay information for those strategies traded
on the Exchange; trading action messages to inform market
participants when a specific option or strategy is halted or
released for trading on the Exchange; and an indicator which
distinguishes electronic and non-electronically delivered orders.
\9\ A BX Depth Port provides access to BX Depth, which is a data
feed that provides quotation information for individual orders on
the BX book, last sale information for trades executed on BX, and
Order Imbalance Information as set forth in BX Options Rules Chapter
VI, Section 8. BX Depth is the options equivalent of the BX
TotalView/ITCH data feed that BX offers under BX Rule 7023 with
respect to equities traded on BX. As with TotalView, members use BX
Depth to ``build'' their view of the BX book by adding individual
orders that appear on the feed, and subtracting individual orders
that are executed. See Chapter VI, Section 1(a)(3)(A).
\10\ BX TOP Port is a data feed that provides the BX Best Bid
and Offer (``BBO'') and last sale information for trades executed on
BX. The BBO and last sale information are identical to the
information that BX sends to the Options Price Regulatory Authority
(``OPRA'') and which OPRA disseminates via the consolidated data
feed for options. BX TOP Port is the options equivalent of the BX
Basic data feed offered for equities under BX Rule 7047. See Chapter
VI, Section 1(a)(3)(B).
\11\ The DROP interface provides real time information regarding
orders sent to the BX Options Market and executions that occurred on
the BX Options Market. The DROP interface is not a trading interface
and does not accept order messages.
\12\ The Exchange also assesses a $500 SQF Port fee, which is
assessed per port, per month. A SQF Port is a port that allows a
Participant acting as options Market Maker to enter its markets into
the BX Options Market. The Exchange is not proposing to amend the
fees assessed for SQF Ports or apply the proposed limit on fees to
SQF Port fees.
\13\ See NASDAQ Options Rules Chapter XV, Section 3(b).
The Exchange believes that its proposal is consistent with Section
6(b) of the Act,\14\ in general, and furthers the objectives of
Sections 6(b)(4) and 6(b)(5) of the Act,\15\ in particular, in that it
provides for the equitable allocation of reasonable dues, fees and
other charges among members and issuers and other persons using any
facility, and is not designed to permit unfair discrimination between
customers, issuers, brokers, or dealers.
\14\ 15 U.S.C. 78f(b).
\15\ 15 U.S.C. 78f(b)(4) and (5).
The Exchange believes that increasing the fee assessed for Order
Entry Ports, CTI Ports, BX Depth Ports, BX TOP Ports, and Order Entry
DROP Ports to $650 per port, per month, per mnemonic is reasonable
because it is competitive with the fees of other exchanges.
Specifically, The NASDAQ Stock Market assesses $650 per port, per
month, per mnemonic for comparable connectivity under Nasdaq Options
Market Rules Chapter XV, Section 3(b). Moreover, the Exchange notes
that it has not increased fees for the connectivity provided under the
rule since it adopted the connectivity options on January 2, 2015,\16\
notwithstanding that costs associated with offering and supporting the
connectivity have increased, which include the cost of technology and
infrastructure. The costs that the Exchange incurs is substantially
similar to those that The NASDAQ Stock Market incurs, since both
exchanges use the same hardware and support services for the ports.
Thus, the Exchange has determined that $650 per port, per month, per
mnemonic is the appropriate fee that will allow it to cover its costs
and realize a profit, while avoiding an overall reduction in the number
of subscribers. The Exchange also believes that the proposed $7,500 fee
cap is reasonable because, taken together with the proposed fee
increase, it will allow the Exchange to cover costs while reducing the
impact of the fees on Options Participants that subscribe to a large
number of ports. Because Options Participants generally need an
increasing number of ports as provided under BX Options Market Rules
Chapter XV Section 3(b) as their activity expands on the BX Options
Market, the Exchange believes that without such a cap Options
Participants may be inhibited from growing their activity on the
Exchange. As a general principal, the Exchange believes that greater
participation on the BX Options Market by Options Participants improves
market quality for all market participants. Thus, in arriving at a fee
cap of $7,500, the Exchange balanced the desire to improve market
quality against the need to cover costs and make a profit.
\16\ See note 4, supra.
DROP Ports to $650 per port, per month, per mnemonic is an equitable
allocation and is not unfairly discriminatory because the increased fee
will apply to all Options Participants that have, or are seeking, the
connectivity provided under the rule. As noted above, the Exchange is
increasing the fees under the rule to align them with the costs
associated with offering the ports as well as to allow the Exchange to
realize a profit. The Exchange believes that the proposed $7,500 fee
cap is an equitable allocation and is not unfairly discriminatory
because the any Options Participant that subscribes to connectivity
under the rule that would otherwise exceed $7,500 per month will have
its fees capped. Although Options Participants that do not have fees
under the rule in excess of $7,500 per month will not benefit from the
fee cap, the Exchange notes that any Options Participant may increase
the number of ports subscribed to receive the fee cap, should their
activity on the BX Options Market warrant increased subscription.
Moreover, Options Participants that do not qualify for the fee cap will
benefit from the greater liquidity provided by Options Participants
that conduct a sufficient level of activity on the BX Options Market to
require connectivity in excess of the fee cap.
The Exchange notes that it is not amending or applying a fee
limitation to SQF Port Fees, which are also provided under BX Options
Market Rules Chapter XV Section 3(b).\17\ The Exchange believes that it
is equitable and not unfairly discriminatory to increase the other port
fees, as proposed herein, and not increase the fee assessed for SQF
Port Fees because SQF Port Fees are used by BX market makers in
connection with their market making activities. Unlike other Options
Participants, BX market makers add value to the market through
continuous quoting and a commitment of capital. The Exchange believes
that not applying a limitation on fees to SQF Port Fees is equitable
and not unfairly discriminatory because the Exchange has found that
maintaining the separation between SQF ports and the other ports under
BX Options Market Rules Chapter XV Section 3(b) is appropriate given
the different purposes for subscribing to the ports. Moreover, the
Exchange does not believe that applying an independent fee limitation
to SQF Port Fees is warranted at this juncture because of the limited
number of SQF ports to which any single market maker subscribes.
\17\ See note 12, supra.
The Exchange does not believe that the proposed rule change will
impose any burden on competition not necessary or appropriate in
furtherance of the purposes of the Act. In terms of inter-market
competition, the Exchange notes that it operates in a highly
competitive market in which market participants can readily favor
competing venues if they deem fee levels at a particular venue to be
excessive, or rebate opportunities available at other venues to be more
favorable. In such an environment, the Exchange must continually adjust
its fees to remain competitive with other exchanges and with
alternative trading systems that have been exempted from compliance
with the statutory standards applicable to exchanges. Because
competitors are free to modify their own fees in response, and because
market participants may readily adjust their order routing practices,
the Exchange believes that the degree to which fee changes in this
market may impose any burden on competition is extremely limited.
In this instance, the proposed changes to the charges assessed for
Order Entry Ports, CTI Ports, BX Depth Ports, BX TOP Ports, and Order
Entry DROP Ports under BX Options Market Rules Chapter XV Section 3(b)
do not impose a burden on competition because the Exchange's
connectivity services are completely voluntary and subject to extensive
competition both from other exchanges and from off-exchange venues. To
the extent that the changes are viewed unfavorably by Options
Participants, the proposed fees increase and fee cap may result in the
Exchange losing subscribership and market participation, which would
likely benefit other exchanges and trading venues. Accordingly, the
Exchange does not believe that the proposed changes will impair the
ability of Options Participants or competing order execution venues to
maintain their
competitive standing in the financial markets.
No written comments were either solicited or received.
The foregoing rule change has become effective pursuant to Section
19(b)(3)(A)(ii) of the Act.\18\
\18\ 15 U.S.C. 78s(b)(3)(A)(ii).
change, the Commission summarily may temporarily suspend such rule
change if it appears to the Commission that such action is: (i)
Necessary or appropriate in the public interest; (ii) for the
protection of investors; or (iii) otherwise in furtherance of the
purposes of the Act. If the Commission takes such action, the
Commission shall institute proceedings to determine whether the
proposed rule should be approved or disapproved.
Use the Commission's Internet comment form (http://www.sec.gov/rules/sro.shtml); or
Send an email to rule-comments@sec.gov. Please include
File Number SR-BX-2017-009 on the subject line.
and Exchange Commission, 100 F Street NE., Washington, DC 20549-1090.
All submissions should refer to File Number SR-BX-2017-009. This file
number should be included on the subject line if email is used. To help
the Commission process and review your comments more efficiently,
the Commission's Internet Web site (http://www.sec.gov/rules/sro.shtml). Copies of the submission, all subsequent amendments, all
written statements with respect to the proposed rule change that are
filed with the Commission, and all written communications relating to
the proposed rule change between the Commission and any person, other
than those that may be withheld from the public in accordance with the
provisions of 5 U.S.C. 552, will be available for Web site viewing and
printing in the Commission's Public Reference Room, 100 F Street NE.,
Washington, DC 20549 on official business days between the hours of
10:00 a.m. and 3:00 p.m. Copies of the filing also will be available
for inspection and copying at the principal office of the Exchange. All
comments received will be posted without change; the Commission does
not edit personal identifying information from submissions. You should
submit only information that you wish to make available publicly. All
submissions should refer to File Number SR-BX-2017-009, and should be
submitted on or before March 15, 2017.
Eduardo A. Aleman,


Company MAXIM LONGEVITY INC. is located in the city of BOCA RATON. The legal address of the company is 200 GLADES RD STE 3. Other interesting information can be found on working days by phone Data not provided. The scheme of travel to the company MAXIM LONGEVITY INC. can be viewed on the interactive map.


We at International Diagnostic Equipment are selling a 13 Panel Tanner Scientific CDOA2135 CLIA Waived Urine Drug Cup, FDA Approved Tests 13 Different Drugs of Abuse.
The Tanner Scientific DOA Multi-Drug Test Cup is a competitive immunoassay that is used to screen for the presence of various drugs and drug metabolites in urine. It is a chromatographic absorbent device in which, drugs within a urine sample are competitively combined to a limited number of drug monoclonal antibody (mouse) conjugate binding sites. When the test is activated, the urine is absorbed into each test strip by capillary action, mixes with the respective drug monoclonal antibody conjugate, and flows across a pre-coated membrane. This all-in-one drug testing kit is ideal for rehabilitation centers, medical facilities, and employers for on-site drug screening.
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Dr.Malpani's Blog: Patients with a sense of humour !
I answer a lot of queries from infertile patients by email.
Many infertile men are obsessed with their sperm count; and want to know how to improve it. I explain to them that the sperm account is not a bank account, that we should not worry about the number. The quality of the sperm are as important as the quality - and in any case, we treat couples - not numbers or lab reports !
One of my patients wrote back, saying - " I only wish my sperm count was like a bank account - one could beg, borrow or steal to boost it :).


Animals suffer from emotional stress just like humans, which the Bailey, Bach and Verbeia Essences are able to help. The modern world that our animals live in is far removed from their evolutionary path and adds anxiety to their daily lives. In the wild horses would explore their large environment in herds and dogs would live in packs.
The Bailey, Bach and Verbeia Essences are here to bring back the utopia of that time, by allowing animals to live out their lives in peace. The Flower Essences are made with only the energy of the flowers so they can be taken alongside other medications; they are also 100% safe. The Essences help to alleviate, fear, grief, anxiety, separation anxiety, excessive grooming and so much more.
Caroline is an Animal Holistic Therapist and writer. She has been using Flower Essences with Animals for over fourteen years and has helped many animals with complex emotional issues. She has clients all over the world who have benefited from the magic of these Essences. Caroline teaches Holistic Therapies for Animals online to Practitioner level and is also very passionate about working with Rescued Animals.