Intel may have unintentionally lowered expectations for its new Pentium 4. Consumers are likely to remember the much ballyhooed move from the Pentium II to the Pentium III, where the only real difference was a set of Streaming SIMD Extensions (SSE).
Intel may have unintentionally lowered expectations for its new Pentium 4. Consumers are likely to remember the much ballyhooed move from the Pentium II to the Pentium III, where the only real difference was a set of Streaming SIMD Extensions (SSE). This time, the transition does merit a full name change, yet Intel may be seen as the boy who cried wolf. The company will have to work doubly hard to convince the public that the Pentium 4 is more than just a faster version of the Pentium III.
Reflecting the popularity of the Internet, Intel has tagged its Pentium 4 improvements with a new name: NetBurst micro-architecture. Boasting 42 million transistors, compared with 28 million transistors for the Pentium III, NetBurst is Intel's first new desktop processor micro-architecture since 1995, when the company introduced the P6 processor core for the Pentium Pro.
Formerly code-named Willamette, the Pentium 4 divides its pipeline into 20 stages, allowing clock frequency to be scaled far higher than with the P6 architecture. Intel was also able to implement Arithmetic Logic Units (ALUs) that run at twice the core frequency. The P4 can therefore execute certain integer instructions in half a clock tick, dramatically speeding up some operations.
This first crop of Pentium 4 desktops combines the Pentium 4 processor with the new Intel 850 chip set and RDRAM memory. The trio allows several significant advances, including a 400-MHz system bus (actually clocked at 100 MHz with four data transfers per clock cycle), which is three times as fast as the fastest 133-MHz Pentium III bus. To keep the system memory from becoming a bottleneck, Intel has implemented dual RDRAM memory channels, for a combined 3.2-GBps throughput.
On the graphics side, the 850 chip set—originally code-named Tehama—supports the 4x AGP interface (as do older 800-series chip sets). It also supports four USB ports instead of the two found on previous systems. Music and game fans will appreciate the 850's ability to support as many as six channels of AC97 audio, but we think that most high-end multichannel audio solutions will still be PCI–board–based.
The Pentium 4 also reduces the number of instructions needed to complete a task by expanding the Pentium III's built-in set of Streaming SIMD Extensions (SSE). Intel refers to the 144 new instructions as SSE2. These optimized instructions are designed to speed up speech recognition, video compression, encryption, image processing, financial calculations, graphics processing, and engineering calculations. Like SSE, SSE2 instructions have to be supported by individual programs, so you won't see their full effect until the next round of software upgrades.
Other features include a low-latency L1 data cache and an Advanced Transfer Cache. The latter shuttles data between the on-chip L2 cache and the processor core at more than twice the speed of the Pentium III.
Many of the oohs and aahs over the new Pentium 4 desktops will come from the higher clock speeds—1.4 GHz and 1.5 GHz at launch. Intel expects to reach the 2-GHz mark by the third quarter of 2001. The Pentium 4 is optimized for clock speed, perhaps because consumers fixate on that number and disregard all else.
The overall performance of any processor is a function of its clock frequency (in MHz or GHz) times the number of instructions per clock (IPC). Intel claims that the Pentium 4's frequency capabilities are increased by more than 40 percent over P6-core processors. However, the Pentium 4's IPC capabilities are actually 10 to 20 percent lower than those of P6-core chips—although according to Intel, the Pentium 4's lower IPC is more than made up for by the higher clock frequency and redesigned processor architecture.
As a result, we didn't expect a 1.5-GHz Pentium 4 to be 50 percent faster than a 1-GHz Pentium III when running processor-intensive benchmark tests or business applications. The benchmark test scores for desktops confirmed this.
For example, look at our 3D WinBench 2000 Processor test, which uses DirectX 7.1 transform and lighting engines that feature an optimized code path for SSE2. The scores were less than 35 percent higher than the scores on the same benchmark test from a group of 1-GHz Pentium III desktops reviewed in our December 5 article "The Perfect PC."
The 3D WinBench Processor test stresses the CPU's ability to perform transform and lighting (T&L) using SSE/SSE2 instructions and does not use the graphics board's T&L engines. We expect many games and other programs to benefit from the hardware T&L engines on graphics cards such as those based on GeForce2 and Radeon graphics chips.
To test business-application performance, we used Business Winstone 2001. Unfortunately, the tests contain code that isn't predictable with high levels of accuracy. This "branchy" code wreaks havoc with the Pentium 4's 20-stage pipeline, as mispredicted branches cause pipeline flushes and reloading of instructions from the correct code path. Case in point: Business Winstone 2001 scores for the 1.5-GHz Pentium 4 desktops averaged only 5 percent higher than the scores for the 1-GHz Pentium III desktops.
To help compensate for the Pentium 4's lower IPC and deep pipeline, Intel has implemented several enhancements that eliminate one-third of the mispredictions that would occur in P6-core processors.
With the Pentium 4 heavily skewed to maximum clock speed, main competitor AMD may be caught in a numbers game. The Athlon maker's CEO has publicly stated that AMD will have a 1.5-GHz Athlon available by the beginning of 2001. Because the Athlon isn't designed to reach high clock speeds at the expense of the IPC, AMD could find it harder to compete in a market where clock speed has become so central to the marketing of computers in the near term. How future 32-bit AMD processors compete with the Pentium 4 remains to be seen.


Let's hear it for moms! Here's to the women who tackle the #World'sToughestJob and deserve nothing short of oodles of praise and attention. Though we mean to constantly let them know how much we love and appreciate them, we often fall short on our follow-through, which is why we're grateful we have a day set aside just for them where we can lavish heaps of Mother's Day messages on them that are chock full of love and praise for all they do.
You've probably started thinking about sending cards to your mother, mother-in-law, and grandmother — and don't forget your sisters, and yes, those pet moms, too! All these women in your life will LOVE to get a Mother's Day card from you affirming what great moms they are, so here are some ideas you can use to let them know you see how hard they work and appreciate them for all they do.
I see you in things I do, I hear you in things I say — and these are some of the things I'm most proud of.
Now that I know what it's like, I really don't know how you did it – and did it all so well. I'm so grateful, though, that I had such a good example to follow. Love you, Mom.
I hope that I can be even a fraction of the wonderful mother you were to me. Have a beautiful Mother's Day.
The truth is, no matter how old we get, we'll always need our moms. And there will always be things she deserves to hear.
Mom, when you thought I wasn't looking — I was. Thank you for the million ways you supported, encouraged, helped, and loved me.
For all the times I didn't say it but should have…thank you, Mom. I love you.
The truth is, Mom…you were pretty much right every time. Thanks for all the good advice, even if it took me awhile to get it.
You're a beautiful person inside and out, and there's no way you could be anything but a fantastic mom.
Get ready for a collection of gifts made with noodles…and love like you've never known.
Take time to take it all in…and know how loved you are. Happy 1st Mother's Day!
The mother of your spouse oftentimes may get overlooked, but let's not forget who gave you your fab partner to begin with. Make her day by sending her some love, too, with a special Mother's Day message for your mother-in-law.
I hope your Mother's Day is filled with things that make you smile.
Out of all the mothers-in-law out there — I got the best. Have a beautiful day.
Most partners want to acknowledge their 'better half', highlighting that they're the 'glue' that makes it all work and keeps their family going.
You're my best friend and a wonderful mother to our children. Everything you do makes our lives so special, and you deserve a beautiful Mother's Day.
You don't hear it nearly as often as you should, but I appreciate you and love you for all you do for me and the kids.
the comfort, the support, and the love that only a mom like you can give.
I know I'm not the best at saying things as much as I should, but I'm always thinking how lucky I am to have someone like you who's an incredible wife and mother.
You deserve a Mother's Day that's every bit as wonderful as you are.
I don't know how you do it all, and I especially don't know how you make it look so easy. I could never do this without your and your love.
You count on them for their support and skill at putting out 'fires' (which seems an everyday occurrence). Let them know nothing they do goes unnoticed or unappreciated.
When you're frazzled, running ragged, and think no one appreciates all you do…I do. Every day.
This Mother's Day is all about letting you know how much I admire you and everything you do for our family.
and I appreciate you every single day.
There's no one I'd rather do this whole crazy parenting thing with than you.
For all the sacrifices and the many ways you show up for our family…thank you.
She's got so much going on and then some. Give her an uplifting message that says you realize how awesome she is at the whole mom thing.
It's your day — shine like the mom rock star you are.
You are freakishly-good at the whole mom thing. Go you!
Wishing you another year of wowing everyone who knows you. Have a great Mom's Day!
Amazing friend and awesome mom — that's you!
Your kiddos have the best mama of all. Cheers to you today!
There's nothing more meaningful (and memorable) than having your mom acknowledge that you're a pretty darn good mom yourself.
I always knew you'd become a wonderful mother because you're such an amazing daughter. Enjoy your Mother's Day.
I'm wishing you a Mother's Day that's every bit as special as you are to me.
On Mother's Day and always, I hope you know how loved you are.
Seems like yesterday I was holding you in my arms. Watching you with your own children fills me with so much pride. Enjoy every moment.
I couldn't ask for a more wonderful daughter and mother for my grandchildren. Love you so much.
She's not only taking care of your adorable grandkids, but she's also caring for your own kid, too, and it's the perfect chance to tell her she's doing a great job.
My grandbabies are so lucky to have such a good mama like you. You deserve to have a wonderful Mother's Day.
Your family knows how fortunate they are to have you — and so do I. Enjoy your Mother's Day!
Hope you know how much I appreciate all the work and good care you give your family every single day.
You do so much every day that I hope you relax today! You deserve it!
You really take such good care of your kids (and mine!). Thank you for all you do.
You've watched and helped each other go through ages and stages.
Let her know how much you admire the great mom she turned out to be.
Despite how hard and frustrating it must be at times, just want you to know that you're a really good mom.
I know it must be easy to think you're doing it all wrong, but from what I see you're doing it all so right. You deserve a fantastic Mother's Day.
You may not always see or realize all she does, but she's caring for your precious nieces and nephews 24/7, and would love to have nod from you that she's doing an A-OK job.
I know being a mom is the hardest thing ever – thanks for all you do. Have a great Mother's Day.
You've always felt more like a sister than in-law. Hope you know how loved you are and that your Mother's Day is amazing.
May your feet be up and your wine glass full! Have a great Mother's Day.
Thinking of you today with lots of love. Enjoy your Mother's Day!
To a great sis-in-law – you're the best and you deserve a great day.
Your love and support have always meant the world to me. I hope your Mother's Day is as beautiful as you are.
You're such a blessing to our family. Thank you for all the love you give and everything you are.
Your aunt would love getting a card full of happy wishes that make her realize how special she is to you.
You always made me feel like one of your own, and I'll never forget how special that felt. Hope you have a beautiful day.
I want you to know that I'm thinking of you and wishing you the happiest Mother's Day ever.
Thank you for being a mother, friend, and confidant. Don't know what I'd do without you.
When I think of you, I think of how your smile lights up a room, and just by your being there, everyone feels happy. Love you so much.
You deserve a Mother's Day that's every bit as special as you are. Love you lots.
You're the best aunt ever. Thanks for being there for me in all the ways that mattered.
Your niece took cues from you and the rest of the family on how to navigate the family circle, and now that she's a mom herself, your thoughtful wishes couldn't be more wanted.
You're the sweetest niece who's also a really good mom. Thinking of you today and hoping you enjoy your Mother's Day.
Raising kids is tough, but you're tougher. You're such a good mom, and I'm so proud of you.
Hope that Mother's Day is full of things that make you feel loved. You deserve it!
Every time I think of you I smile. I know you have so much going on, so I hope you take some time for just yourself today to relax and renew.
Your sweet kids are such a testament to what a great mom you are. Cheers to you!
You're good at taking care of everybody else, but today it's all about YOU. Enjoy your day!
She wants to be there for you, yet tries hard not to 'replace' your biological mom. That's a tough balancing act, but she does it because she loves you. Knowing she's doing ok by you would mean the world to her.
Thanks for being such an important part of my life and trying so hard. I appreciate you every day.
You give so much to our blended family, and I know it's not always easy. Today, it's our turn to take care of YOU!
Not only are you my stepmom, but you're my friend, too, and that means so much.
I wish you a day full of all the things you add to our lives: fun, laughter, and love.
Thank you for always making our home such a warm and comforting place to come back to.
I hope you have a wonderful Mother's Day that's full of all your favorite things.
Whether you met her in her infancy or much later, you tried your best to show her what it means to be a good mom. Now she's trying, too, and a note of love and encouragement would give her all the feels.
I'm so proud of the woman and mother you've become, and I wish you the happiest Mother's Day.
Remember that I'm always here if you need me, and I'm thinking of you and wishing you a beautiful Mother's Day.
Hope this day reminds you of what a special mother and stepdaughter you are.
A stepdaughter like you is one of the best things that could ever happen to a family. Hope you feel how loved you are today and every day.
Watching you with your family reminds me of us and all the special memories we share.
Let's leave the 'step' out of it — you're my daughter, and I love you and wish you a beautiful Mother's Day.
Maybe you were close, or maybe you kept each other at arm's length — just as most sisters do from time to time. But the love remains and always feels good when it's shared.
Always figured you'd make a pretty cool mom, and you totally are. Have a great Mother's Day.
Nothing's too good wish for a great stepsister like you. Hope you're reminded all day of how loved you are.
You should feel really proud of the mother you've become, because you pretty much rock. Enjoy your special day.
You were there for me from the moment we met — your kids are so lucky. Love ya.
Just seeing you happy with a beautiful family of your own makes me happy, too.
I know how hard you try every day; that's what makes you such a great mom.
If only all pets could have the kind of love you give. You rock!
There are lots of great pet moms out there, but you totally win Pet Mom of the Year.
Whatever you decide to write in your cards, one thing's for sure—the special ladies in your life are going be so touched that you thought of them and sent some Mother's Day love their way. Here's to moms!
Share Mother's Day greeting cards from the heart!
Share exceptional ecards with exceptional moms!
Give her the love & thanks she deserves!


text:
Ruperra Castle
Ruperra Castle Photo - Andrew King - Wikipedia - lic. under CC BY-SA 2.0
Location: Lower Machen, Caerphilly, Wales.
Condition: Ruins.
Ownership / Access: Mr Ashraf Barakat, For sale.
Opening Times: Check their website for more info.
Price of Admission: Check their website for more info.
Notes: Ruperra Castle is a Grade II* Listed building and Scheduled Ancient Monument, situated in Lower Machen in the county borough of Caerphilly, Wales. It is was built in 1626, now it is in a ruined condition and up for sale. Built in 1626 by Sir Thomas Morgan,[5] Steward to the Earl of Pembroke, it was one of the first of the 'mock' castles to be built in Wales. King Charles I spent two nights at Ruperra Castle in 1645 shortly after the Battle of Naseby. Resultantly the royal coat of arms was added to the decoration on the South Porch, and the present public footpath from Rudry to the Castle is still known as "King's Drive." It was bought as his home by wealthy John Morgan "the merchant" for 12,400 pounds. He was unmarried and it was consolidated on his death in 1715 into the Tredegar estates of the Morgan family. It was destroyed by fire in 1785, and rebuilt, resultantly became home, especially in the 19th century, to the heir of the estate. Godfrey Charles Morgan, 2nd Baron, 1st Viscount Tredegar, who was a captain in the 17th Lancers during the Charge of the Light Brigade at the Battle of Balaklava in the Crimean War, was born at Ruperra.[3][4] It was during the early Victorian age that he undertook a lot of development, adding three new lodges as well as in 1826 a now listed iron bridge, allowing a carriage way through Coed Craig Ruperra and across the Rhymney River to Lower Machen Church where the family and their servants attended Sunday services.[3][4] After the death of army officer turned politician Colonel Frederick Courtenay Morgan in 1909, his son Courtenay Morgan, 1st Viscount Tredegar, embarked on a programme of refurbishment. Minor adjustments were made to the main house, but his major improvement was the building of a new stable block to replace the one destroyed by fire in 1895, a new reservoir and pump house in the deer park, and a new power house fitted with duplicate steam-driven generators, dynamos and boilers. The 1840s brew house, laundry and dairy range were converted to accommodate the estates staff. Courtenay's son, Evan Morgan, 4th Baron, 2nd Viscount Tredegar, poet and noted eccentric with links to Aldous Huxley, Lord Alfred Douglas, Augustus John, Nancy Cunard and H. G. Wells, then owned Ruperra. He grew up there and, apparently, refused to sell it to William Randolph Hearst, whose lover, the actress Marion Davies, wanted a home in South Wales. Later, after Davis saw photographs of St Donat's Castle, Vale of Glamorgan in Country Life magazine, that property was bought and revitalised by Hearst in 1925 as a gift to Davis. But by 1935, the Morgan fortune was in decline. Despite having invested heavily in the property, the Morgan seat and main home remained Tredegar House, with Ruperra used as a weekend hunting lodge. The entire 3,000 acres (1,200 ha) estate was put up for sale, with the contents either moved to Tredegar House or sold in three-day auction. Un-staffed and effectively abandoned, at the start of World War II, like many other large estate houses, it was taken over by the British Army, under whose control in 1941 it was destroyed by another fire. Post-war, the entire estate was sold onwards as farm land, with the castle left as a decaying ruin, the status in which it remains today. Mr Ashraf Barakat bought the castle in 1998, and tried to revive the sport of polo in Wales.[9] After failing in a planning permission application to construct nine residential flats within the building, due to the discovery of nesting of both Greater and Lesser horseshoe bats, he later applied to demolish it to build housing, but again planning permission was refused. In September 2010, Barakat put the castle up for sale, at a price of £1.5M.
How To Get To Ruperra Castle (Map):
Ruperra Castle Links:
Ruperra Castle On Wikipedia
Ruperra Castle Preservation Trust
Castlewales.com on Ruperra

redpajama_set_name: RedPajamaCommonCrawl


text:
AC / DC will release a new album
AC / DC will release a new studio album, "PWR UP", on November 13. The new record was recorded and produced with Brendan O'Brien.
The Australian band confirmed its return to the music industry with a new album via a message posted on social media "ARE YOU READY? #PWRUP "
It is estimated that AC / DC has sold over 200 million records worldwide.
By adruby on Thu, 10/08/2020 - 08:11
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Go Driving Tuition: Learn to drive quickly, safely, economically - and pass first time!
Learn to drive quickly, safely, economically - and pass your test first time!
Naturally you want to learn to drive and pass your test as soon as possible so that you can enjoy the freedom of the road - so you're all ready to Go! That's why you can't make a better choice than Go Driving Tuition! Based in south Manchester, Go will help you to pass your driving test safely, swiftly and at a reasonable cost. So we'll offer you a course of lessons to match your budgets and needs; then we'll ensure that you develop good driving habits from the start - and we'll show you how to use your driving skills to pass your driving test first time!
At Go, our aim is to ensure that you're driving safely and independently as soon as possible, so our team of highly trained male and female instructors (all approved by the Driving Standards Agency) will coach you in a calm, reassuring and positive driving environment. At the same time, you'll be at the wheel of a smart, responsive Go vehicle that's easy to handle and a real joy to drive! So no wonder we have excellent first-time pass rates plus a top reputation! What's more, our growing business is largely from personal recommendations from happy, satisfied customers who've passed with Go!
Starting out? Then start right here!
If you're starting out on your driving career and don't even have a provisional licence yet, this website has a page dedicated to everything you need to know about driving, from driving licence application through to applying for your test - plus you'll find a whole range of invaluable click-throughs and important websites all about driving well and safely!


text:
Steroid receptor binding to nuclei: Effect of assay conditions on the integrity of chromatin
Robert A. Webster, Thomas C. Spelsberg
Various incubation conditions previously used in cell-free assays of steroid receptor binding to nuclei were evaluated on the basis of their effect on the integrity of the nuclear chromatin. Incubation of nuclei for 60 min in whole cytosol containing no added salt at 25°C resulted in significant DNA degradation and some proteolysis. This deterioration in the integrity of the chromatin increased its capacity to bind the [3H]-progesterone-receptor complex, possibly via exposure of previously "masked" acceptor sites. Decreasing the temperature and/or increasing the salt concentration reduced or eliminated these changes in the chromatin. Incubation of nuclei in an ammonium sulfate-fraction of the cytosol, which contained the partially purified progesterone receptor, resulted in no detectable deterioration of the chromatin integrity irrespective of the temperature (≤25°C) or the added salt concentration (0-0.15 M KCl). These results suggest that some of the conflicting reports on the nature of the nuclear acceptor sites for steroid receptors could be due to the use of inappropriate assay conditions, which permit degradation of the nucleo-protein and result in altered levels of steroid receptor binding. (Steroid/ Progesterone/Nuclei/Chromatin.).
Journal of Steroid Biochemistry
Fingerprint Dive into the research topics of 'Steroid receptor binding to nuclei: Effect of assay conditions on the integrity of chromatin'. Together they form a unique fingerprint.
Steroid Receptors Chemical Compounds
Assays Chemical Compounds
Chromatin Chemical Compounds
Progesterone Receptors Chemical Compounds
Proteolysis Medicine & Life Sciences
Deterioration Chemical Compounds
Webster, R. A., & Spelsberg, T. C. (1979). Steroid receptor binding to nuclei: Effect of assay conditions on the integrity of chromatin. Journal of Steroid Biochemistry, 10(4), 343-351. https://doi.org/10.1016/0022-4731(79)90318-2
Steroid receptor binding to nuclei : Effect of assay conditions on the integrity of chromatin. / Webster, Robert A.; Spelsberg, Thomas C.
In: Journal of Steroid Biochemistry, Vol. 10, No. 4, 04.1979, p. 343-351.
Webster, RA & Spelsberg, TC 1979, 'Steroid receptor binding to nuclei: Effect of assay conditions on the integrity of chromatin', Journal of Steroid Biochemistry, vol. 10, no. 4, pp. 343-351. https://doi.org/10.1016/0022-4731(79)90318-2
Webster RA, Spelsberg TC. Steroid receptor binding to nuclei: Effect of assay conditions on the integrity of chromatin. Journal of Steroid Biochemistry. 1979 Apr;10(4):343-351. https://doi.org/10.1016/0022-4731(79)90318-2
Webster, Robert A. ; Spelsberg, Thomas C. / Steroid receptor binding to nuclei : Effect of assay conditions on the integrity of chromatin. In: Journal of Steroid Biochemistry. 1979 ; Vol. 10, No. 4. pp. 343-351.
@article{f3fc2faca4764230b04e2fa225e8633e,
title = "Steroid receptor binding to nuclei: Effect of assay conditions on the integrity of chromatin",
abstract = "Various incubation conditions previously used in cell-free assays of steroid receptor binding to nuclei were evaluated on the basis of their effect on the integrity of the nuclear chromatin. Incubation of nuclei for 60 min in whole cytosol containing no added salt at 25°C resulted in significant DNA degradation and some proteolysis. This deterioration in the integrity of the chromatin increased its capacity to bind the [3H]-progesterone-receptor complex, possibly via exposure of previously {"}masked{"} acceptor sites. Decreasing the temperature and/or increasing the salt concentration reduced or eliminated these changes in the chromatin. Incubation of nuclei in an ammonium sulfate-fraction of the cytosol, which contained the partially purified progesterone receptor, resulted in no detectable deterioration of the chromatin integrity irrespective of the temperature (≤25°C) or the added salt concentration (0-0.15 M KCl). These results suggest that some of the conflicting reports on the nature of the nuclear acceptor sites for steroid receptors could be due to the use of inappropriate assay conditions, which permit degradation of the nucleo-protein and result in altered levels of steroid receptor binding. (Steroid/ Progesterone/Nuclei/Chromatin.).",
author = "Webster, {Robert A.} and Spelsberg, {Thomas C.}",
journal = "Journal of Steroid Biochemistry and Molecular Biology",
publisher = "Elsevier Limited",
T1 - Steroid receptor binding to nuclei
T2 - Effect of assay conditions on the integrity of chromatin
AU - Webster, Robert A.
AU - Spelsberg, Thomas C.
N2 - Various incubation conditions previously used in cell-free assays of steroid receptor binding to nuclei were evaluated on the basis of their effect on the integrity of the nuclear chromatin. Incubation of nuclei for 60 min in whole cytosol containing no added salt at 25°C resulted in significant DNA degradation and some proteolysis. This deterioration in the integrity of the chromatin increased its capacity to bind the [3H]-progesterone-receptor complex, possibly via exposure of previously "masked" acceptor sites. Decreasing the temperature and/or increasing the salt concentration reduced or eliminated these changes in the chromatin. Incubation of nuclei in an ammonium sulfate-fraction of the cytosol, which contained the partially purified progesterone receptor, resulted in no detectable deterioration of the chromatin integrity irrespective of the temperature (≤25°C) or the added salt concentration (0-0.15 M KCl). These results suggest that some of the conflicting reports on the nature of the nuclear acceptor sites for steroid receptors could be due to the use of inappropriate assay conditions, which permit degradation of the nucleo-protein and result in altered levels of steroid receptor binding. (Steroid/ Progesterone/Nuclei/Chromatin.).
AB - Various incubation conditions previously used in cell-free assays of steroid receptor binding to nuclei were evaluated on the basis of their effect on the integrity of the nuclear chromatin. Incubation of nuclei for 60 min in whole cytosol containing no added salt at 25°C resulted in significant DNA degradation and some proteolysis. This deterioration in the integrity of the chromatin increased its capacity to bind the [3H]-progesterone-receptor complex, possibly via exposure of previously "masked" acceptor sites. Decreasing the temperature and/or increasing the salt concentration reduced or eliminated these changes in the chromatin. Incubation of nuclei in an ammonium sulfate-fraction of the cytosol, which contained the partially purified progesterone receptor, resulted in no detectable deterioration of the chromatin integrity irrespective of the temperature (≤25°C) or the added salt concentration (0-0.15 M KCl). These results suggest that some of the conflicting reports on the nature of the nuclear acceptor sites for steroid receptors could be due to the use of inappropriate assay conditions, which permit degradation of the nucleo-protein and result in altered levels of steroid receptor binding. (Steroid/ Progesterone/Nuclei/Chromatin.).
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology


Hollow Metal Window Frames, Interior & Exterior | DWS, Inc.
For both interior or exterior situations, when a highly durable window frame is needed, hollow metal window frames are the answer. They both compliment and accentuate metal doors and metal door frames, and they fit as either a light duty, medium duty or heavy-duty solution.
Allegion, the makers of some of the finest hollow metal doors and hollow metal door frames, also work with DWS to provide you with some of the finest hollow metal window frames. They can be specially made for any application, and we have the tooling needed for custom preparation and welding too.
In many commercial applications, window glass can be large and heavy, which is the perfect environment for a hollow metal window frame. Overall strength is unsurpassed by any other material, and even if the glass is damaged from force of impact, the chances are that the frame will hold up and not need replacement, even if the glass does.
Both cleaning and maintenance are minimal and easy on a hollow metal window frame. Wiping them down with a damp cloth, or using a mild detergent, will make them look as good as new. They will never chip, warp or sliver, which makes them the ideal choice in an institutional setting, especially around kids.
There are several design options, but the most common ones are the types that have the same features of metal doors and metal frames. This symmetry in design gives a professional and elegant look in any setting they are featured, remaining pleasing to the eye as well as functional.
Like all metal, hollow metal frames are fire resistant, and they will not start on fire when exposed to flames. They are also weather resistant, and regardless of an exterior or interior application, they will retain their good looks through rain, snow, the humidity of summer or when used as window frames around pools.
Although there are a variety of application uses for hollow metal window frames, they always go best when coupled to metal frames or metal doors. There are two types of metal used, either steel or aluminum. Choose the one that best fits your needs and the commercial application that they will be used for.


text:
The Priests' Garments
1 "Now take a Aaron your brother, and his sons with him, from among the children of Israel, that he may minister to Me as b priest, Aaron and Aaron's sons: c Nadab, Abihu, d Eleazar, and Ithamar. 2 "And e you shall make 1 holy garments for Aaron your brother, for glory and for beauty. 3 "So f you shall speak to all who are gifted artisans, g whom I have filled with the spirit of wisdom, that they may make Aaron's garments, to consecrate him, that he may minister to Me as priest. 4 "And these are the garments which they shall make: h a breastplate, i an 2 ephod, 3 j a robe, k a skillfully woven tunic, a turban, and l a sash. So they shall make holy garments for Aaron your brother and his sons, that he may minister to Me as priest. 5 "They shall take the gold, blue, purple, and scarlet thread, and the fine linen,
6 m "and they shall make the ephod of gold, blue, purple, and scarlet thread, and fine woven linen, artistically worked. 7 "It shall have two shoulder straps joined at its two edges, and so it shall be joined together. 8 "And the 4 intricately woven band of the ephod, which is on it, shall be of the same workmanship, made of gold, blue, purple, and scarlet thread, and fine woven linen. 9 "Then you shall take two onyx n stones and engrave on them the names of the sons of Israel: 10 "six of their names on one stone and six names on the other stone, in order of their o birth. 11 "With the work of an p engraver in stone, like the engravings of a signet, you shall engrave the two stones with the names of the sons of Israel. You shall set them in settings of gold. 12 "And you shall put the two stones on the shoulders of the ephod as memorial stones for the sons of Israel. So q Aaron shall bear their names before the LORD on his two shoulders r as a memorial. 13 "You shall also make settings of gold, 14 "and you shall make two chains of pure gold like braided cords, and fasten the braided chains to the settings.
15 s "You shall make the breastplate of judgment. Artistically woven according to the workmanship of the ephod you shall make it: of gold, blue, purple, and scarlet thread, and fine woven linen, you shall make it. 16 "It shall be doubled into a square: a span shall be its length, and a span shall be its width. 17 t "And you shall put settings of stones in it, four rows of stones: The first row shall be a 5 sardius, a topaz, and an emerald; this shall be the first row; 18 "the second row shall be a turquoise, a sapphire, and a diamond; 19 "the third row, a 6 jacinth, an agate, and an amethyst; 20 "and the fourth row, a 7 beryl, an 8 onyx, and a jasper. They shall be set in gold settings. 21 "And the stones shall have the names of the sons of Israel, twelve according to their names, like the engravings of a signet, each one with its own name; they shall be according to the twelve tribes. 22 "You shall make chains for the breastplate at the end, like braided cords of pure gold. 23 "And you shall make two rings of gold for the breastplate, and put the two rings on the two ends of the breastplate. 24 "Then you shall put the two braided chains of gold in the two rings which are on the ends of the breastplate; 25 "and the other two ends of the two braided chains you shall fasten to the two settings, and put them on the shoulder straps of the ephod in the front. 26 "You shall make two rings of gold, and put them on the two ends of the breastplate, on the edge of it, which is on the inner side of the ephod. 27 "And two other rings of gold you shall make, and put them on the two shoulder straps, underneath the ephod toward its front, right at the seam above the 9 intricately woven band of the ephod. 28 "They shall bind the breastplate by means of its rings to the rings of the ephod, using a blue cord, so that it is above the intricately woven band of the ephod, and so that the breastplate does not come loose from the ephod. 29 "So Aaron shall u bear the names of the sons of Israel on the breastplate of judgment over his heart, when he goes into the holy place, as a memorial before the LORD continually. 30 "And v you shall put in the breastplate of judgment the 10 Urim and the Thummim, 11 and they shall be over Aaron's heart when he goes in before the LORD. So Aaron shall bear the judgment of the children of Israel over his heart before the LORD continually.
31 w "You shall make the robe of the ephod all of blue. 32 "There shall be an opening for his head in the middle of it; it shall have a woven binding all around its opening, like the opening in a coat of mail, so that it does not tear. 33 "And upon its hem you shall make pomegranates of blue, purple, and scarlet, all around its hem, and bells of gold between them all around: 34 "a golden bell and a pomegranate, a golden bell and a pomegranate, upon the hem of the robe all around. 35 "And it shall be upon Aaron when he ministers, and its sound will be heard when he goes into the holy place before the LORD and when he comes out, that he may not die.
36 x "You shall also make a plate of pure gold and engrave on it, like the engraving of a signet:
HOLINESS TO THE LORD. 37 "And you shall put it on a blue cord, that it may be on the turban; it shall be on the front of the turban. 38 "So it shall be on Aaron's forehead, that Aaron may y bear the iniquity of the holy things which the children of Israel hallow in all their 12 holy gifts; and it shall always be on his forehead, that they may be z accepted before the LORD.
39 "You shall a skillfully weave the tunic of fine linen thread, you shall make the turban of fine linen, and you shall make the sash of woven work.
40 b "For Aaron's sons you shall make tunics, and you shall make sashes for them. And you shall make 13 hats for them, for glory and c beauty. 41 "So you shall put them on Aaron your brother and on his sons with him. You shall d anoint them, e consecrate them, and 14 sanctify them, that they may minister to Me as priests. 42 "And you shall make f for them linen trousers to cover their 15 nakedness; they shall 16 reach from the waist to the thighs. 43 "They shall be on Aaron and on his sons when they come into the tabernacle of meeting, or when they come near g the altar to minister in the holy place, that they h do not incur 17 iniquity and die. i It shall be a statute forever to him and his descendants after him.


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is the very root of judgment, character, and will. . .
than to give practical instructions for bringing it about.
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and there are times to go out into the world and find such a thing for yourself.
We will be exploring in depth how our five senses can help us remain present to our lives.
All these classes are limited in numbers (6-10 participants) and occur in Tufnell Park.
The fee is £ 75 per child for one hour session per week for five weeks.
Class will go ahead only if there are enough participants.
May I be in my wonder in every day.
May I allow myself to be in wonder in every choice I make.
Thank you Catalina Stogdon for your lovely words.
It was such a pleasure to meet you and share some of my experience with you!


Harpenden and District Local History Society was founded in 1973 with the intention of researching and recording Harpenden's history and making it known by means of meetings, publications and exhibitions. The Society's website was built by CommunitySites back in 2010 as a natural extension of the society's aims, and enables users to contribute their memories and stories. It continues to grow and had nearly 800 pages at the last count.


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We hope you can join us on our walkthrough as we thoroughly evaluate your home's accessible features and components. Extensive experience and advanced tools give you an equitable perspective. Armed with unique investigative equipment, such as moisture meters and thermal imaging cameras, we are able to examine your home beyond the visible spectrum. See the full scope of your home in a new light.
Mr. Hamner was quite thorough and willing to extend his home knowledge to me which was greatly appreciated, especially as a first-time home buyer. He was not rushed and took time to explain what he was doing all throughout the inspection process.
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Homescope Inspection Services offers flexible availability and hours to Virginia residents, including, but not limited to the counties of Prince William, Loudoun, and Fairfax.


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GVN Convenes First-of-its-kind Conference to Evaluate the Public Health Magnitude of Long Covid
By vgn1 | July 22, 2022 | 0
GVN Convenes First-of-its-kind Conference to Evaluate the Public Health Magnitude of Long Covid and Define a Global Research Roadmap to Address the Crisis
World Leaders in Science, Healthcare, Academia, Business and Government Discuss Issues and Ramifications of Long Covid
Baltimore, MD, USA (July 22, 2022) – The Global Virus Network (GVN), a coalition of world leading medical virology research centers, yesterday concluded a two-day gathering on the 'Science of Long COVID.' The first-of-its-kind conference reviewed the wealth of cohort data on long COVID, constructed a framework to characterize and define the conditions, and identified the most critical and urgent areas of research needed to better understand, diagnose, and treat this developing public health crisis.
"There is no doubt that long COVID has proven to be as nightmarish as we feared, but what we heard over the past two days reassured us that our colleagues from the global scientific community are ready to come together to rise to the challenge. To do that effectively, the scientists of the GVN and those who participated in the conference call upon governments, foundations, and other institutions worldwide to commit the billions of research dollars required to address the catastrophe of long COVID," said Prof. Christian Bréchot, M.D., Ph.D., GVN President and Associate Vice President for International Partnerships and Innovation at the University of South Florida.
Across the globe, nearly half of COVID-19 survivors struggle with persistent symptoms four months or more after diagnosis and are colloquially referred to as long COVID or long haulers. Conference speakers from around the world focused on the vast public health implications of this highly prevalent condition. During the proceedings, they outlined approaches to and research of this complex phenomenon that has already cost Americans alone an estimated $50 billion annually in lost income, a data point that could translate to $200 billion or more of lost income around the globe.
"The prevalence of long COVID is staggering," said Robert Gallo, M.D., Co-founder and Scientific Chair of the GVN and Director of the Institute of Human Virology at the University of Maryland School of Medicine. "Two years into the pandemic, we have concrete and irrefutable proof from cohort studies following individuals as they experience a litany of symptoms—memory problems, relentless fatigue, difficulty breathing, cardiac concerns, insomnia and more. What we lacked, and what this conference achieved, is a data-driven and scientific baseline that helps scientific, policymaking and healthcare stakeholders to understand and approach the underlying aspects of long COVID and consequently arrive at a global research framework."
As part of the process to establish a global research framework, the conference presented key scientific and clinical evidence on long COVID's far-ranging global impact:
243 million long COVID cases worldwide with a disproportionate burden affecting females (49% versus 37% for men); continental differences (Asia 51% of COVID cases becoming long COVID, Europe 44%, U.S. 31%); and lasting elevated risk levels among long COVID survivors for cardiovascular disease and diabetes.
Striking clinical parallels exist between "COVID-fog" and "chemo-fog," with the whole-body inflammation in both causing changes to brain circuitry and cognitive impairment. Different cytokines—immune hormones that affect immune and other cells—may be promising biomarkers, and even therapeutic targets, to measure long COVID's effects in the body and ameliorate long COVID disease.
30-50% of long haulers report breathlessness and 10-20% report cough. More severe lingering effects of long COVID on the respiratory system include damage and scarring of lung tissue. These changes are not necessarily predicted by the severity of the disease or whether a patient was hospitalized. Vaccination has reduced the numbers of individuals with long COVID respiratory disease, while new COVID variants show milder effects.
Risk factors for long COVID include Type 2 Diabetes, SARS-CoV-2 RNAemia, Epstein-Barr virus viremia, microclots, protein misfolding, and both pre-existing and disease-specific autoimmunity. These associations are most detectable at the time of diagnosis, emphasizing the need for early disease measurements to advance understanding.
"Despite the fact that enormous numbers of people are suffering from persistent symptoms after recovering from Covid, it's been very difficult to define a syndrome to even start to consider how to make a difference. The conference was a great chance to bring together scientists and clinicians to brainstorm about the best future approaches, "said Eric Rubin, M.D., Ph.D., Editor in Chief, New England Journal of Medicine and Adjunct Professor of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health.
The GVN is committed to fostering true collaboration among virologists, medical specialists, governments, and non-governmental organizations alike to combat long COVID's critical threat to international health. The conference wrapped up with a call to action for governments and funding agencies to allocate resources to strengthen scientific training and response mechanisms across these priority focus areas:
Conduct large scale data analysis on existing cohort studies. Bring the scientific community together to share insights and use artificial intelligence to advance understanding.
Acknowledge the effect of time. Research cannot be relegated to studying the effects of ancestral strains of the virus prior to the availability of vaccines. We need diverse samples from patients infected by all subvariants, segmented by whether or not they were vaccinated and whether or not they had prior infection.
Transition to interventional clinical trials. A substantial amount of observational data exists on long COVID, documenting an effect on different organ systems in varying degrees of severity for a range of times. We now must move to understand the risks and benefits of treatment within those ranges of time and the best biomarkers to track them. We will need innovative trial designs to move swiftly from early phase studies to large scale clinical trials.
Linkage of people living with Long COVID to research activities. We recognize the desperation and frustration of people living with Long COVID and echo their calls for urgent investment in scientific and clinical research so that we can inform the design of much-needed clinical services, identify better diagnostic tests as well as optimal models of care, and discover treatment options for Long COVID.
The GVN and the leads of its long COVID Task Force agree that long COVID is an opportunity to create a cohesive, global public health response unlike any other historical effort. To better arm policymakers and decision-makers in prioritizing funding for research and interventions, we've mapped out in a clinical framework assessing how the virus preys on pre-existing conditions and interacts with our biological mechanisms, resulting in clinical manifestations. More than 243 million people worldwide have or had long COVID. The scientific pursuit of solutions will require adequate funding and a continued commitment to information sharing, which is why the GVN commits to convening regular global conferences to continue this urgent discussion.
The Global Virus Network (GVN) is essential and critical in the preparedness, defense and first research response to emerging, existing and unidentified viruses that pose a clear and present threat to public health, working in close coordination with established national and international institutions. It is a coalition comprised of eminent human and animal virologists from 69 Centers of Excellence and 11 Affiliates in 37 countries worldwide, working collaboratively to train the next generation, advance knowledge about how to identify and diagnose pandemic viruses, mitigate and control how such viruses spread and make us sick, as well as develop drugs, vaccines, and treatments to combat them.
No single institution in the world has expertise in all viral areas other than the GVN, which brings together the finest medical virologists to leverage their individual expertise and coalesce global teams of specialists on the scientific challenges, issues and problems posed by pandemic viruses. The GVN is a non-profit 501(c)(3) organization. For more information, please visit www.gvn.org. Follow us on Twitter @GlobalVirusNews
Posted in Press Release, SARS-CoV-2


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Bitelog is a Food Diary Website
Our Strong Points
Tons of calculators about calorie consumption and ideal weight. Is our specialty.
2 Diary Styles: The usual Daily Diary where every day is a separate page, and Scroll Diary where one sees all days together.
First class service, full personal attention. We can afford one-to-one communication with all our users.
Diet Interviews. Good questions, carefully thought of answers.
Happy logging & Eat well Bitelog team
Please select gender, age and height. Then press one of the weight calculator buttons.
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Loyola Radiologist Aruna Vade, MD, Receives Highest Honor from Chicago Radiological Society
MAYWOOD, IL – The Chicago Radiological Society has given Loyola Medicine pediatric radiologist Aruna Vade, MD, FACR, its highest honor, the Distinguished Service Award.
Dr. Vade was honored for her "outstanding leadership in organized medicine on local, state and national levels and her many years of dedicated service to radiology."
Dr. Vade is medical director of pediatric radiology and a professor in the departments of radiology and pediatrics at Loyola University Chicago Stritch School of Medicine. She is a fellow of the American College of Radiology.
Dr. Vade is a past councilor and current alternate councilor for the American College of Radiology and a member of the executive committees of the Chicago and Illinois radiological societies. She has served on numerous committees and in various officer positions for local and state radiological societies, including president of the Chicago and Illinois radiological societies. She is a member of the Pediatric Radiology Committee of the American College of Radiology and also has served on the college's credentials committee.
Dr. Vade has been active in the Indian Medical Association of Illinois, serving on its executive committee and in various officer positions, including president.
Dr. Vade is an author of two book chapters and 64 papers in peer-reviewed medical journals. She is a reviewer for two medical journals, Pediatric Radiology and Case Reports in Radiology. She has given 90 presentations and invited lectures and more than 50 scientific exhibits at local, national and international meetings.
Dr. Vade and her husband, Suresh Vade, MD, have two children, Shilpa, a radiologist who trained under Dr. Aruna Vade at Loyola, and Anand, and two grandchildren. Dr. Vade and her husband live in Burr Ridge, Illinois, and have traveled extensively throughout the world. They have visited every continent, including Antarctica.
About Loyola Medicine and Trinity Health
Loyola Medicine, a member of Trinity Health, is a quaternary care system based in the western suburbs of Chicago that includes Loyola University Medical Center (LUMC), Gottlieb Memorial Hospital, MacNeal Hospital and convenient locations offering primary and specialty care services from 1,877 physicians throughout Cook, Will and DuPage counties. LUMC is a 547-licensed-bed hospital in Maywood that includes the William G. and Mary A. Ryan Center for Heart & Vascular Medicine, the Cardinal Bernardin Cancer Center, a Level 1 trauma center, Illinois's largest burn center, a certified comprehensive stroke center and a children's hospital. Having delivered compassionate care for over 50 years, Loyola also trains the next generation of caregivers through its teaching affiliation with Loyola University Chicago's Stritch School of Medicine and Marcella Niehoff School of Nursing. Gottlieb is a 247-licensed-bed community hospital in Melrose Park with 150 physician offices, an adult day care program, the Gottlieb Center for Fitness, the Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park. MacNeal Hospital is a 374-bed teaching hospital in Berwyn with advanced inpatient and outpatient medical, surgical and psychiatric services, advanced diagnostics and treatments. MacNeal has a 12-bed acute rehabilitation unit, a 25-bed inpatient skilled nursing facility, and a 68-bed behavioral health program and community clinics. MacNeal has provided quality, patient-centered care to the near west suburbs since 1919.
Trinity Health is one of the largest multi-institutional Catholic healthcare systems in the nation, serving diverse communities that include more than 30 million people across 22 states. Trinity Health includes 92 hospitals, as well as 109 continuing care locations that include PACE programs, senior living facilities and home care and hospice services. Its continuing care programs provide nearly 2.5 million visits annually. Based in Livonia, Mich., and with annual operating revenues of $18.3 billion and assets of $26.2 billion, the organization returns $1.1 billion to its communities annually in the form of charity care and other community benefit programs. Trinity employs about 129,000 colleagues, including 7,800 employed physicians and clinicians. Committed to those who are poor and underserved in its communities, Trinity is known for its focus on the country's aging population. As a single, unified ministry, the organization is the innovator of Senior Emergency Departments, the largest not-for-profit provider of home health care services—ranked by number of visits—in the nation, as well as the nation's leading provider of PACE (Program of All Inclusive Care for the Elderly) based on the number of available programs.
Sr. Manager, Media Relations
jritter@lumc.edu


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Milton Keynes College awarded £5million from SEMLEP towards City Centre Campus project
Milton Keynes College has been awarded 5million from SEMLEP
Milton Keynes College has been awarded £5million from SEMLEP this month, through funding available from their Local Growth Fund skills capital investment programme.
This funding contributes to the major £38m project to relocate the college to refurbished Council premises in Milton Keynes centre which is due to open in Summer 2021.
The project forecasts 400 additional learners by 2021 and 1800 new learners by 2024/25 which will make a major contribution to developing the technical skills and apprenticeships in the area.
Imelda Galvin, chief operating officer, Milton Keynes College said: "Milton Keynes College is delighted to receive this funding which will support our goal of moving to a single campus in the heart of Milton Keynes. This in turn will allow more students to access the College and mean that students choose the course they really want to study, rather than the one that's closest to home.
"We will now move forward with our partners over the summer as our plans gather pace."
Judith Barker, director of programmes and governance at SEMLEP added: "Milton Keynes has a very successful and growing economy.
"Investment in Milton Keynes College responds to the skills needs of MK employers and confirms SEMLEP's commitment to improving the skills offer for growing local communities in our area.
"The award follows a very competitive funding competition and detailed due-diligence and appraisal process. I will be working very closely with the college to help them deliver this."


The use of acupuncture in the U.S. by individuals living with HIV/AIDS represents a novel area of clinical and academic study. Seeking relief from antiretroviral medication side effects, such as digestive symptoms or pain, many patients use acupuncture as an adjuvant to their medical care. Effective control of side effects is often associated with enhanced adherence to medication. For this reason, examining the value of acupuncture from therapeutic, public health, and economic perspectives becomes compelling. The first paper in this book(Dynamic Interplay of Adherence to HIV-Medication, Quality of Life and Side Effect Management) uses a conceptual model to explain these dynamic inter-relationships. Cost-effectiveness of Acupuncture to Improve and Sustain Adherence to Antiretroviral Therapies, the second paper, explores cost considerations of enhanced adherence. The final paper (Examining Changes in Utilization of Acupuncture Care Related to Reduction in Ryan White Care Act Funding) addresses utilization using bivariate and multivariate analyses to explore disparities associated with demographic and behavioral issues.


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Pop/Jazz/Hip-Hop/Virtuoso Violinist Gareth Johnson Releases Highly Anticipated New Single "Straight Gangster"
Jimmy Stars World 3 months ago
Pop/Jazz/Hip-Hop/Virtuoso Violinist Gareth Johnson has just released his highly anticipated new single "Straight Gangster." Now available worldwide, download or stream today!
...Regarded as one of the most musical and technically superior artists of his generation; bringing to the stage the vitality, charisma and energy of a 21st century modern virtuoso!
Gareth's love for the beautiful sounds of the violin came after seeing Itzhak Perlman in concert. His desire and passion to play at that point, along with his mother who holds a Doctorate in Music Education, gave him the pathway needed to become the master classical, Hip-Hop/Jazz/R&B and Pop artist he is today.
His studies with master violinists, performances all over the world, and a desire to reach a broader base to spread his love of the violin has allowed him to cross musical genres. This extraordinary talent crosses and connects all borders, all musical genres from Johnny Cash to Stevie Wonder and Bruno Mars, as well as Metallica and Guns & Roses, right into Luis Fonsi & Daddy Yankee's Despacito.
Gareth Johnson is the 2Pac of violin and the first Hip-Hop/Jazz/R&B and Pop violinist to write, produce and perform his music. Together with Gareth's writing and producer partner Juan Blair they have created magic.
In the past 5 years Gareth has taught and performed in South Africa: Johannesburg and Durban as well as Europe: England and the Netherlands. He adds these experiences to past tours in Asia, specifically China, Taiwan and the Republic of Hong Kong, Central America: El Salvador and Europe: Germany and Austria. Gareth has performed with Joshua Bell, Itzhak Perlman, Pinchas Zukerman, and several other world-renowned string players.
Gareth Johnson is that once in a lifetime artist.
Download "Straight Gangster" on iTunes in the United States here:
https://music.apple.com/us/album/straight-gangster-single/1478567728
Follow Gareth Johnson on the web:
Website: Garethlive.com
Spotify: https://open.spotify.com/artist/7vESlM3ioSEIc3rUg0mk7r?si=VEUNjgMORdCu_IZCDEaFug
Facebook: https://www.facebook.com/gareth.lailan
Instagram: https://www.instagram.com/gareth_live/
Twitter: https://twitter.com/GarethJ87111472
Reverbnation: https://www.reverbnation.com/garethjohnson1
Sonicbids: https://www.sonicbids.com/band/gareth-johnson/
Tagged in : gareth johnson, straight gangster, virtuoso, violinist, 2Pac of Violin, hip hop, jazz, r&b, virtuoso violinist, itzhak perlman,
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The Search for Yield and the Size Premium in Emerging Market Corporate Debt
43 Pages Posted: 20 Dec 2018
See all articles by Charles W. Calomiris
Charles W. Calomiris
Columbia University - Columbia Business School; National Bureau of Economic Research (NBER)
Mauricio Larrain
Sergio L. Schmukler
World Bank - Development Research Group (DECRG)
Tomás Williams
George Washington University - Department of Economics; George Washington University - Elliott School of International Affairs (ESIA)
Date Written: December 15, 2018
Emerging market corporations have significantly increased their borrowing in international markets after the global financial crisis. We show that this expansion was led by large-denomination bond issuances (bonds with face values exceeding US$300 million, and often exceeding US$500 million). The drastic shift in the pattern of bond issuances reflects increased investor willingness to purchase emerging market corporate bonds so long as they are included in international bond indexes, which require face values of at least US$300 and US$500 million. Inclusion in the index gives investors the advantage of holding more liquid bonds, which also makes them more similar to those issued by U.S. corporates and emerging market sovereigns. Additionally, those bonds allow investors to target performance closer to the market benchmark. After 2008, emerging market firms started facing a new trade-off. They could borrow at a lower cost (a full percentage point lower) by issuing index-eligible bonds, which often imply raising more financing than needed. Or, they could borrow smaller quantities at a higher cost, while avoiding accumulating substantial cash assets. Because the liquidity premium for large-denomination bonds is sizable, many companies have issued them. As a result, larger firms have become more likely to issue them and some smaller firms have issued large bonds for the first time, which has entailed large increases in their post-issuance cash holdings. The overall changes after 2008 in emerging market corporate issuance are not apparent in advanced economies.
Keywords: benchmark indexes, corporate bonds, corporate financing, emerging markets
JEL Classification: F21, F23, F32, F36, F65, G11, G15, G31
Calomiris, Charles W. and Larrain, Mauricio and Schmukler, Sergio and Williams, Tomás, The Search for Yield and the Size Premium in Emerging Market Corporate Debt (December 15, 2018). Available at SSRN: https://ssrn.com/abstract=3303628 or http://dx.doi.org/10.2139/ssrn.3303628
Columbia University - Columbia Business School ( email )
601 Uris, Dept. of Finance & Economics
National Bureau of Economic Research (NBER)
Columbia University ( email )
Sergio Schmukler (Contact Author)
World Bank - Development Research Group (DECRG) ( email )
1818 H. Street, N.W.
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HOME PAGE: http://www.worldbank.org/en/about/people/s/sergio-schmukler
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Monroe Hall, Suite 340
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Wisch, J. A. Texas Jewish Post (Fort Worth, Tex.), Vol. 29, No. 17, Ed. 1 Thursday, April 24, 1975, newspaper, April 24, 1975; Fort Worth, Texas. (https://texashistory.unt.edu/ark:/67531/metapth753195/: accessed April 20, 2019), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; .


One hour from Torino, escape into the bucolic hills of Piedmont. This beautiful 17th Century stone villa sits on 5.6 hectares (fourteen acres) at an altitude of 600 meters (2000 feet) near the small village of Bonvicino and four miles from Dogliani, in the heart of Piedmont, Italy.
Villa San Lorenzo di Bonvicino provides a perfect base for exploring the Piemonte region. Enjoy walking through Italian hill towns and vineyards, visit the well-known towns of Monforte D'Alba and Barolo (nine and 12 miles away). Sit on the balcony, sipping your morning coffee or enjoying a glass of wine at sunset while gazing out at the rugged and lush green mountain landscape. On clear days, enjoy spectacular views of the Alps.
I purchased and renovated Villa San Lorenzo because we wanted to provide a beautiful oasis for vacationers seeking delicious food and wine, lovely hikes, untouristed villages and enjoy a slower pace. The villa's renovation was completed between 2008 and 2015, including new bathrooms, gourmet chef's kitchen, beds, linens, antique furnishings, British satellite TV, high-speed internet, plumbing, electrical. Modern conveniences are combined with the antiquity of this centuries old farmhouse. Furnishings combine comfort in keeping with the style of the region and preservation of the house. There are seven bedrooms (Four rooms with Queen Size Beds, 3 rooms with the choice of 2 single beds or one queen bed). Seven modern bathrooms total with bath/shower, and one WC off of the chef's kitchen.
The villa includes a large chef's kitchen with six (6) gas burner stove, as well as a smaller fully equipped kitchen, two living spaces and one large dining/living space with floor to ceiling windows. The property offers privacy, spectacular views in a beautiful peaceful setting. Perfect for a family or a group of friends.
I loves to bake bread and pizza so I added a wood-fired traditional brick oven for pizza and bread in 2007. Swim in the 11 x 5 meter (36 feet x 16.5 feet) swimming pool with a view of Murazzano and the Italian Alps. Dine at the stone table overlooking the hills of the Alta Langa. Enjoy cooking in the gorgeous chef's kitchen, dining al fresco, or choose from one of the region's many delicious restaurants. Local cuisine offers fresh regional dishes based on seasonal ingredients.
The property is completely private, nestled in the Alta Langa hills. Just minutes from town (cafes, restaurants, shopping, cinema), you will feel peacefully secluded on this spacious property. Pick fresh figs, apples, cherries, and blackberries just outside your front door.
Walk directly from the house to view hawks, warblers, finches, sparrows, rabbits, deer, fox, coyotes, or drive to one of the many walks nearby. Local wineries abound, featuring the internationally acclaimed Barolo and Barbaresco wines.
The nearby town of Alba is known as the home of the famous white truffle. Bra prides itself on being the heart of the Slow Food movement. Nearby Cherasco is known for its famous chocolate, as well as offering a cultural museum and film retrospectives. Horseback riding and swimming are just minutes away.Dogliani offers a choice of cafes where you can sample homemade gelati, enjoy a cappuccino or stay for lunch or dinner.
Visit the farmer's market in a different local town each day of the week. Take a walk or drive to Bossolasco to sample their famous chocolates (including a variety of hot chocolate beverages) and views stretching over the entire region.You may want to take a trip to the Italian Riviera near Savona on the Ligurian Coast or to the Alps for skiing or hiking, both about an hour's drive away. Cinque Terre, Nice, and Milan are approximately two hours away. All linens provided. Daily or weekly cleaning available at additional cost.
Please email me at clay@29vsl.com in order to check availability and plan your visit to this stunningly beautiful part of Italy and share in La Dolce Vita!


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Juston R. Givens - Phillips Murrah P.C.
Juston R. Givens' practice is focused in commercial and business litigation and entertainment law. Juston represents a diverse group of individuals and businesses covering a wide range of industries, from construction to agriculture to entertainment.
A Director at Phillips Murrah, Juston represents a diverse group of individuals and businesses covering a wide range of industries, from construction to agriculture to entertainment. Juston's practice is primarily in the litigation of such matters, and his approach as a "problem solver" serves his clients well, regardless of the type of dispute in which they are involved.
Born and raised in rural Oklahoma Panhandle, he was immersed in the agriculture industry, gaining the unique perspectives that only farming and ranching can provide. These early life lessons positioned Juston to have a rare insight into the agriculture industry, and have served his clients well. Whether it is representing a family in a difficult disassociation matter or representing a farmer relative to the breach of an agreement to purchase grain, his familiarity with the agriculture industry allows him to guide his clients through the legal issues affecting their farms, ranches, and businesses.
As a former band-member, Juston has an insider's view into the music and entertainment industry, giving him strategic insight into effective representation of his clients, which has led him to representing promoters, venue owners, artists, and booking agencies. Familiarity with the practical side of the entertainment business, combined with considerable legal experience, has given Juston the opportunity to build an entertainment practice unique to Oklahoma City.
While in law school, he was a merit scholar and a member of Phi Delta Phi legal fraternity. During the summer of 2006, he completed the International Association of Defense Counsel's Trial Academy at Stanford University.
Juston lives in Edmond, Oklahoma, with his wife, Casie, and their children, Sawyer and Josie. He spends most of his free time with his family, enjoying time at the lake or taking an occasional trip to Colorado. He still enjoys playing music from time to time, and he also has an avid interest in classic cars of all kinds.
With a philosophy that good lawyers should be "problems solvers," Juston uses his unique insights and background to guide clients through difficult times and situations, when much can be at risk. Juston's expertise and approach starts with learning his clients' business; whether farmer, contractor, or musician, he develops legal strategies with his client's business objectives as the main focus.


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Get ready! you thought your old pictures were bad! Well we have found 16 old pre fame celebrity photos that you will barely recognize them in! You won t believe how much different they looked before!Ryan Seacrest: I bet you weren t ready for that picture! You can barely recognize him!


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Horses Daily
Horse Market
Horse Sport to Remain in Olympic Games
ALL EQUESTRIAN | DRESSAGE DAILY | EVENTING DAILY | SHOW JUMPING DAILY
OLYMPIC EQUESTRIAN GAMES
The FEI President has welcomed today's confirmation by the IOC that equestrian sport will be in the Olympic programme for the 2024 Games and approval of the Olympic formats submitted by the FEI for the Tokyo 2020 Games. The quota for equestrian at the 2020 Games remains unchanged.
"The IOC's confirmation of equestrian on the Olympic programme for the 2024 Games and approval of the new formats for Tokyo 2020 is a direct acknowledgment of our willingness to adapt and modernise our sport, so all the work to drive change and increase universality has been worthwhile", FEI President Ingmar De Vos said.
"Approval of the formats for Tokyo means that we can now increase the number of flags in equestrian sport in line with the Agenda 2020 recommendations. With more than 30,000 athletes registered to compete in our three Olympic disciplines – and the numbers are growing every year – our new formats mean that athletes from more countries than ever before will now have the opportunity of one day realising their dream of representing their country at the Olympic Games."
The new formats include teams of three and no drop score across the Olympic disciplines (Eventing, Dressage and Jumping) and the use of reserve athletes (horses and riders) for medical reasons. The format changes were approved by the FEI's member National Federations at last year's FEI General Assembly in Tokyo (JPN) following almost two years of consultation.
"It wasn't easy for our community to make such drastic changes to our Olympic formats, but the National Federations knew the importance of this decision and ultimately supported the proposed changes. Their willingness to embrace this change is without any doubt the reason we have got this fantastic news from the IOC today."
Ingmar De Vos also welcomed today's confirmation of the IOC Executive Board's unanimous approval of a working group recommendation that both the 2024 and 2028 Games be awarded later this year. The recommendation will be voted on at an IOC Extraordinary Session in Lausanne (SUI) next month and, if passed, the two Games will then be allocated at the IOC Session in Lima (PER) in mid-September, with Paris (FRA) and Los Angeles (USA) as the two candidate cities.
"We have visited the equestrian venues at Paris and Los Angeles and we're really excited to know that they will be hosting the next two editions of the Games after Tokyo 2020, as they both offer a fantastic opportunity to showcase our sport. We will have an iconic venue in Paris, as equestrian will be staged in the grounds of Versailles, with the chateau as a truly spectacular backdrop not only for the stadium, but also for the cross country. And for Los Angeles we will be in the beautiful Sepulveda Basin, just 15 minutes from the Athletes Village, on the site of an existing golf course.
"Both venues provide us with a great opportunity to deliver the Games in a cost-effective way and, as France and the United States have a long and successful equestrian tradition, there will be huge public support for our sport."
Olympic and World Champions Head Impressive Entry List for 2016 Rolex Kentucky Three-Day Event
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You are a heartbeat away from ship's captain. As member of the management team, you shape the culture of the restaurant. It will carry your imprint. In the absence of the Restaurant General Manager (RGM), the buck stops with you. Your role is to build the capability of your team, continue running great shifts, and partner with your RGM to make your restaurant stand out from the field. This is a training ground for you because all that you learn here will be taken with you when you become RGM. Savor every experience, lean on your RGM for feedback and coaching, and gain confidence in your leadership of others and the restaurant!


Snaith Primary School - What an amazing week!
Thank you all so much for your kind words, cards, emails and good wishes following our 'OUTSTANDING' Ofsted news. We are delighted for our whole school community with this report which we feel truly reflects our school. We will look to hold a special celebration with you all later in the summer term.


text:
Bristol Observer
A Stepsaver Publication
Features, Good Times
Walter Trout is back, healthy, and playing the blues
July 31, 2015 • Comments Off on Walter Trout is back, healthy, and playing the blues
By MIKE CHAIKEN
EDITIONS EDITOR
Walter Trout is honest.
"I thought I was done," said the blues guitarist in a phone interview earlier this year.
He recalled how he was in a hospital in Nebraska. His liver had failed. He had just had a transplant. He had lost more than 120 pounds, half of his body weight.
Walter said his son came to visit him in the hospital and brought along the bluesman's trusty Fender Strat. His son wanted Walter to play again.
But, said Walter, "I was too weak to hold the guitar or lift it."
So the nurses handed the Strat to him.
"I couldn't press down on the strings," said Walter. "I lost all my muscle."
That's when he thought his days as a bluesman were over.
But when he went home at last after the transplant, he said, "I played and played."
"Now I think I'm playing better than ever," said Walter.
"I feel great," said Walter, who is back up to a healthy weight.
Fans will get a chance to see for themselves how great Walter is playing when the fully recovered guitarist steps up on the stage at the Infinity Music Hall in Norfolk Friday night.
As Walter explained it, the liver disease snuck up on him. He would get cramps in his left forearm and hands. He said he tried everything to resolve it, but it didn't work.
"I was in excruciating pain," said Walter, who is a recovering alcoholic.
He had no idea it was liver disease.
At the time his liver was failing, he and his family were living in Los Angeles. He needed a new liver. But there were too many people ahead of him waiting for a liver as well. His wife discovered that he had an 18 percent survival rate if he stayed in LA. In Nebraska, he would have an 83 percent chance of survival.
The family moved to Nebraska. Within seven weeks of moving to Omaha, Walter said he had a new liver.
At that point if a transplant was not performed, Walter said doctors expected him to survive no more than 10 days.
"I was pretty much dead," he said.
As the disease took its toll on Walter's body, it also played with his head.
"I would lay in my hospital bed and watch myself on YouTube," said Walter. "I couldn't relate to that guy."
"I can't do that and I don't think I can do it again," Walter said he told himself.
When Walter wrote and recorded his most recent album, "The Blues Came Calling," he was already sick. (This was prior to the transplant.) "I was barely able to walk… I'd drive to the studio and hobble in."
Where he normally would spend 10 hours a day in the studio, said Walter, now he could only manage two hours. There were a few days where Walter would have studio time booked and he had to call in. "I can't do it today."
"It was pretty tough," he said.
And those times informed the music found in the grooves of that release.
Fans offered a great deal of support during those dark days in the hospital and after the transplant, thanks to the posts shared by his wife on his website. The fans offered words of support. And they also offered up donations through a crowdsource funding account established by Walter.
The assistance from fans was needed, said Walter. The medical expenses were mounting. And since Walter was sick, he couldn't play. And if he couldn't play, he couldn't tour to earn a living.
"The response was overwhelming."
During his illness, Walter found out that his music meant something to people. "It was an incredible thing to realize.'
Now, the liver is doing fine. Walter is doing fine. And when he was interviewed, it was clear he was rejuvenated.
By the time you read this, Walter was expected to have entered the studio to record a follow up to "The Blues Came Calling." He said he had accumulated a lot of musical and lyrical ideas, given his circumstances.
"It's taken me a while to figure out what I want to say and how I want to say it," said Walter. "The last album was dark," he said. Now, he said, all he sees in his life is sunshine.
However, he said, don't expect him to record an album of variations of "Kumbaya." After all, he is a bluesman.
The blues is about living a hard life. And Walter has been through some hard times.
"It's definitely deepened my appreciation for the genre," said Walter of his chosen musical form.
"I love lots of music… Charlie Mingus, Miles Davis, Joni Mitchell, Bill Monroe," said Walter, "but the blues has been always first and foremost my favorite."
When Walter comes to Connecticut, fans will hear a musician who has been practicing every day for this opportunity.
Given how long he was laid up, said Walter, "It's almost like starting over. I'm learning my entire catalogue. I'm going through 22 albums. We're doing songs we've never done live or resurrected for the set list." It's also the first time he's had a chance to play in concert the songs from "The Blues Came Calling." When the album finally came out, he was too ill to tour behind that album.
Walter Trout and his band play the Infinity Music Hall, Route 44, Norfolk on Friday, July 31 at 8 p.m. Tickets are $34 to $44
For more information, go to InfinityHall.com or WalterTrout.com
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Jose Gonzalez has revealed the details of his forthcoming album.
'In Our Nature' — the follow-up to his 2005 debut 'Veneer' — is due out in the US on September 25 via Mute.
Gonzalez is currently touring in South America and will be playing several festival dates this summer as well as touring the US this fall.


Completely renovated ranch in Morningside with pool on almost 1 acre! Lots of windows makes this home very sunny. Home boast 6 bedrooms & 5 full baths. Beautiful hardwoods throughout. Gourmet kitchen w/ monogram ss appliances, huge island, granite countertops & walk-in pantry open to keeping room w/fireplace & breakfast area. Separate formal living room, family room and another great room! Perfect for entertaining. Huge, fenced in yard. 2 car garage, carport & lots of additional parking. Unfinished basement great for storage. This is a must see! Wont last.
From Atlanta go North on I-85. MergeontoEXIT86towardBuford Hwy. TaketheMonroe Drexit towardPiedmont Rd S. TurnleftontoMonroe Dr. becomesPiedmont Cir. TurnrightontoPiedmont Rd. TakeleftontoCheshire Bridge Rd. RightontoLenox Rd.
1981 Lenox Rd has 6 bedrooms and 5 bathrooms located in Atlanta GA, Fulton County. This property is listed for sale at $1,074,000 and is currently active and accepting offers.


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World Cup 2022: Messi saves Argentina from elimination in 2-0 win against Mexico
The entire world tuned in as Lionel Messi and his squad retrieved a successful rescue mission against Mexico in a 2-0 victory.
Playing at the Lusail Stadium, Argentina fought hard at the beginning of the match to win all three points against Mexico, in what was a must-win Group C clash.
In the 10th minute, Mexico received a free-kick which Cesar Montes took to the left side of the pitch, with captain Hector Herrera missing the catch.
Both teams played aggressively in the match, with referee Daniele Orsato signalling several warnings to the two sides.
Mexico's Nestor Araujo received the first yellow card for a bad foul, as he took down Marcos Acuna.
A quarter of the way through the match, Argentina held most of the possession at 67.4%, with Mexico holding down the defensive line against the tournament favourites.
In the 34th minute, Messi was awarded a threatening free-kick from the right corner which curled itself into the hands of goalkeeper Guillermo Ochoa.
Before the whistle blew for halftime, Lautaro Martínez headed the ball from the centre of the box, slightly missing the net.
Mexico responded with an attack of its own as Alexis Vega's free-kick was metres away from clocking in a point for the underdogs.
Emiliano Martinez rescued the ball swiftly again, bringing Argentina's fears to an end.
After halftime, Argentina seemed focussed, yet desperate to make an opportunity count against the Mexicans.
With countless free-kicks gifted, Messi missed another as the ball flew over the box.
The pressure was felt within the stadium as the Mexican defence cut several runs by Messi's star-studded squad.
The Argentinian talisman would get his chance in the end, firing a shot that beat Ochoa's plunge and lodged into the bottom right corner of the net.
Gerardo Martino made a few surprise substitutions after the goal, bringing in forward Raul Jimenez and Uriel Antuna in the 67th minute.
Martino's defence strategy failed to stop 21-year-old Enzo Fernandez from receiving an assist from Messi, as he drilled a right-footer into the top corner in the 87th minute.
The match continued to run with 6 minutes of extra time that only found Mexico collapsing to an admirably-led Argentine squad.


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