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text:
Q: Visual Studio 2015 Build Time for Small Project There are many questions on SO about improving the build time in Visual Studio (cf. here, here, etc.), but the vast majority of answers are aimed at projects which are fairly large. Many of these answers (e.g. increasing amount of parallel builds) will only have a marginal effect on small projects, which is what motivates this question.
I am using Visual Studio Express 2015 with one solution, a single C++ project, containing only three files: an 800-line source file, and two .h files. I am running on Windows 7, my processor is Intel Core i5, CPU 2.60GHz, RAM 8GB.
My build time is a staggering 1 minute or more.
Based on suggestions in other SO threads, I have emptied my %temp% and prefetch directories, but this only had a marginal effect. I changed my code to remove as many warnings as possible. I removed all the unnecessary files from the VS directories for my project. My antivirus is disabled.
Here and here it was suggested that an SSD could help. I find it hard to believe, however, that my performance should be this poor with HDD.
I would be glad to hear any suggestions about this issue. Thank you in advance.

A: Some things you can do (not all may be relevant to your code):
Remove unneeded includes.
Build without optimization except for when doing release builds.
Use extern templates where possible.
Split your code into multiple source files so that only a subset of it needs recompilation when you make changes.
Use precompiled headers.

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I split the lesson into several areas: technique studies, reading studies (if student is interested in reading), improvisation practice, learning songs.
Spotswood (NJ), Milltown (NJ), South River (NJ), Helmetta (NJ), North Brunswick (NJ) .
Postal Code(s) associated with East Brunswick, NJ: 08816 .
The above search is a free service maintained by DoReMiWORLD.com for the benefit of private music teachers, as well as music students and their parents. Our goal is to help you locate a private music instructor, for example, a private piano teacher, a private violin teacher, a private voice coach, an online music teacher or another music education specialist who may offer private music lessons or online lessons to music students in East Brunswick New Jersey.
Private music instruction is considered to be the best way to learn to play a musical instrument. Use this directory to find a private music teacher offering music lessons in your local area (East Brunswick NJ) or online lessons around the world. At the moment, our directory is limited to the United States, Canada, United Kingdom, Australia, United States, and New Zealand. This music teachers directory classifies private music instructors by instrument, such as private piano teachers (for private piano lessons), private voice teachers (for private voice lessons), private violin teachers (for private violin lessons), etc. Please use the above search function to find a private music teacher near you.
We welcome the following types of instructors in our East Brunswick New Jersey directory: Accordion Professionals, Dulcimer Coaches, Harp Professionals, Trumpet Instructors, Percussion Tutors, English Horn Teachers, Flute Teachers, Drums Instructors, Piccolo Educators, Banjo Educators, Viola Tutors, Electric Guitar Instructors, Lute Educators, Cello Educators, Saxophone Teachers, Piano Coaches, Harpsichord Instructors, Bass Educators, Acoustic Guitar Tutors, Tuba Teachers, Viola Da Gamba Tutors, Trombone Professionals, Mandolin Teachers, Bassoon Professionals, Electric Bass Tutors, Keyboard Instructors, Voice Professionals, Classical Guitar Educators, Bass Guitar Teachers, Violin Coaches, Organ Coaches, Recorder Instructors, Double Bass Coaches, Clarinet Coaches, French Horn Professionals, Oboe Instructors, Brass Teachers, Woodwinds Educators, Ukulele Coaches, Bagpipes Tutors .


WHY INVEST IN OUR HARD MONEY LOANS?
Did you know you can roll your IRA or 401k in to either a self-directed IRA or self-directed Pension and fund other peoples' real estate investment transactions and your own?
Borrower defaults on the loan and you have to foreclose on the property.
You, the lender, need your capital at some point during the term of the loan.
These are the primary risks that come to mind, not to say there aren't others, but these are the most common risks associated with such an investment. We try to mitigate/minimize the first 2 by only loaning a maximum of 70% of the value, so you should be in a good enough equity position to not lose any or most of your investment. There are a number of other ways to mitigate this risk, which can be discussed during a consultation call. Regarding the 3rd point, if you worry that you may need the capital throughout the duration of the loan, then this may not be a good investment for you. However, if this does happen, there are other investors who may be interested in purchasing that note from you.
Disclaimer: The returns stated above are the interest rates charged to the borrower, and what you as an investor would earn assuming the borrower complies with the terms and conditions of the loan, therefore in no way is KC Investor Funding guaranteeing or promising these returns. Actual terms are dependent upon the borrower and the actual loan provided. Past performance does not determine or dictate future performance. Any capital used by investors should be risk capital Every investor must carefully look at their financial situation and only invest funds that they are financially able to lose.
KC Investor Funding or principals do hereby declare they are NOT a Financial Advisor, Licensed United States Securities Dealer, Broker, or U.S. Investment Advisor. This is not an offer to purchase or sell securities. The acquisition of a Note and Deed of Trust or Mortgage Deed or a participation therein does not constitute the "purchase" or "sale" of a "security" within the meaning of the Securities Act of 1933, the Securities Exchange Act of 1934 or Rule 10b5 promulgated thereunder, any applicable state securities statute or law, or any rule or regulation under any of the foregoing.


text:
Lumino City
Lumino City is a BAFTA award-winning handmade puzzle adventure game. By exploring the city, and using your ingenuity piece together all sorts of puzzling mechanisms to help the people who live in its unique world. Discover gardens in the sky, towers marooned high on an immense waterwheel, and houses dug precariously into cliffs. To create the environment, a ten foot high model city was built by hand and by laser cutter, with each motor and light wired up individually, bringing the scenes to luminous life.
It's no exaggeration to say that this unique puzzler is one of the most interesting, beautiful, and delightful games in years. Kids and adults alike will be blown away by its gorgeous visuals, captivated by its haunting ambient music, and reeled in by puzzle after mind-bending puzzle.
Kids can learn critical-thinking skills, inductive and deductive reasoning, logic and pattern recognition, sequencing, musical technique, and much more. Though it isn't explicitly a learning game, its rich inquiry-based gameplay brims with experimentation, hypothesis testing, discovery, and logic puzzles. While it's not social in a traditional sense, it frequently requires players to work with the characters and get them to help each other, which introduces the idea of cooperation. Kids will become immersed in the narrative, grapple with the puzzles, and practice perseverance as they travel through the beautiful world of Lumino City.
Lumino City is a wonderful puzzle adventure crafted entirely by hand out of paper, card, miniature lights, and motors.
Through this gorgeous environment weaves a clever, charming and puzzling adventure. Lumi's grandfather, the caretaker of Lumino City, has been kidnapped. To find him, you must explore the city and figure out the fascinating mechanisms that power this unique world.
Winner of numerous international awards, including the BAFTA for Artistic Achievement alongside nominations for Innovation and Best British Game, Lumino City now finds its home on the App Store as the perfect tactile experience for iPhone and iPad.
Lumino City has an estimated 8 - 10 hours of gameplay and no In-App Purchases.
AN ENTIRELY HANDMADE CITY. Everything you see on screen was made using paper, cardboard and glue, miniature lights and motors.
A UNIQUELY BEAUTIFUL WORLD TO EXPLORE. Venture beyond the city gates to discover gardens in the sky, boats marooned high on an immense waterwheel, and houses dug precariously into cliffs.
AWE INSPIRING PUZZLES. Play with real objects within each scene. Control windmills in the clouds, provide power to a house using only lemons plus your own ingenuity, and work out how to win at the most puzzling pinball table ever created.
A PERFECT EXPERIENCE FOR TOUCHSCREENS. With a seamless interface optimised for iPhone / iPad and tactile puzzles made from real materials, you'll feel like you're diving into a miniature world of physical playthings.
RECORD AND SHARE. New for iOS 9, use Replay Kit to screen record full motion video of the wonders you discover, then share it with other players and viewers online and on your social networks.
iCLOUD SYNCING. Switch play between all your iOS devices and pick up where you left off.
FAST DOWNLOAD, BETTER PERFORMANCE. Lumino City uses the latest iOS9 App Thinning technology to ensure you download only what you need. Hard disk space is saved, downloads are faster.
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redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Issues with creating objects of classes in Python I am trying to make a sword appear when I press the space bar and disappear when I hit key 5.
if event.type == pg.KEYUP:
                if event.key == pg.K_ESCAPE:
                    self.quit()
                if event.key == pg.K_SPACE:
                    self.sword = Sword(self, self.player.rect.centerx-7, self.player.rect.bottom, self.player)
                if event.key == pg.K_5:
                    self.sword.kill()

I can make the first sword appear and disappear without any issue, but when I try to press the spacebar again, I get this error message:
File "/Users/(User)/Desktop/ZeldaGame/sprites.py", line 183, in __init__
    self.image.set_colorkey(WHITE)
AttributeError: 'Sword' object has no attribute 'set_colorkey'

Here is my Sword class:
class Sword(pg.sprite.Sprite):
    def __init__(self, game, x, y, entity):
        self.groups = game.all_sprites
        pg.sprite.Sprite.__init__(self, self.groups)
        self.game = game
        self.image = self.game.sword
        self.image.set_colorkey(WHITE)
        self.rect = self.image.get_rect()
        self.x = x
        self.y = y
        self.rect.x = x
        self.rect.y = y
        if entity.direction == 'down':
            self.image = pg.transform.rotate(self.image, -90)

        def update(self):
            kill()

Could anyone help me make the sword able to appear, disappear, and appear over and over again?

A: Warning: I don't know anything about PyGame.
It seems as if game.sword initially, before the very first sword is created, is a pygame.Surface object - This is just a guess, because you didn't show that part of the code. (set_colorkey seems to be a pygame.Surface method, and by virtue of the fact that you can invoke Sword.__init__ the first time without any errors tells me that game.sword must initially be a pygame.Surface object, otherwise self.image.set_colorkey(WHITE) would raise an error).
Then, the second time you press the spacebar, game.sword will be refering to a Sword object, since you executed self.sword = Sword(... the first time you pressed the spacebar. You enter the second sword's __init__, but now game.sword refers to a Sword, not a pygame.Surface. Swords don't have a set_colorkey method, hence the error (I'm guessing pygame.Sprite does not inherit from pygame.Surface).


text:
DIGITAL MARKETING NEWS
Timothy Taylor Gallery Relocates in London to Townhouse Double Its Size -ARTnews
A rendering of Timothy Taylor's new London gallery.
COURTESY TIMOTHY TAYLOR
After 15 years at its prior location in London, Timothy Taylor gallery will move to a new and expanded headquarters in the city's Mayfair district.
The gallery's new London address will be 15 Bolton Street, putting it within walking distance of the Royal Academy of Arts and other galleries such as David Zwirner and Stephen Friedman. Timothy Taylor, which also maintains a New York venue in Chelsea, will now be located in a five-story townhouse with 4,500 square feet of space—more than double the size of its previous home.
"Having programmed that space for 15 years, I wanted a change," Timothy Taylor, the gallery's founder, told ARTnews. "Quite frankly, I think many of the artists wanted a change as well."
Taylor's previous space was, like those of many art enterprises in Mayfair, a white-cube gallery. The townhouse, he said, offers new opportunities. "Gallery design has evolved into something that's more domestic," Taylor said. "You've got wooden floors, you've got windows allowing the outside inside, and you've got lighting systems accommodating both natural and artificial light. There is a sense that people are being invited to see the work in a living environment."
First up is a three-person exhibition featuring work by Simon Hantaï, Pierre Soulages, and Antoni Tàpies, all of whom are on Taylor's roster (which also includes artists such as Alex Katz, Eddie Martinez, and Kiki Smith). The inaugural exhibition is due to open in September.
Expanding in London these days can be a risky affair, as some British dealers have cited the ongoing threat of Brexit and the country's precarious state as a reason to be conservative about growing operations. But Taylor said he sees his gallery's relocation as a way to further tap the art world in London and beyond.
"There is, of course, a precarious political situation, but it doesn't affect the international art world," the dealer said. "London remains very, very relevant. People want to come here and see great things, and galleries have to keep evolving to stimulate people, to get them here and get them to look. This home is going to do just that."
Arthur Jafa, Lithuania Win Top Prizes at Venice Biennale -ARTnews
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For 50th Anniversary of Stonewall Rebellion, Public Art Fund Will Restage Felix Gonzalez-Torres Billboard -ARTnews
Integrate sets sights on event leads with $34M purchase of Akkroo
Copyright 2019 - Designed by Manuel


The Possibilities: This idea can apply to every type of museum or display. Example if you have a diorama of the Boston Tea Party and then the touch screen next to it will have the following people to learn more about: John Adams, John Hancock, James Otis, Josiah Quincy, Paul Revere and Dr. Joseph Warren.
My 4 year old son helping himself to some info about the fish in the tank in front of him.
So do…keep information brief and easily accessible right where it's needed.
This entry was posted on January 13, 2015 by Paulina Constancia in Create, Explore and tagged everyday solutions, learning tools.


text:
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A new free Microsoft IT Solution Assessment Program launched for Bulgarian small and medium business
December 21, 2022 | CEE Multi-Country News Center
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To support digital transformation of small and medium business (SMBs) in Bulgaria, Microsoft launched a Solution Assessment Program. A new program fully founded by Microsoft gives the opportunity to small and medium businesses to nominate themselves for assessment and analysis their readiness – for successful digital transformation via following link: Solution Assessment Program (microsoft.com) The four-phased program structured to conduct an analysis of specific business needs of each organization, identify best options for increasing productivity and IT security, innovation, growth, and based on data-driven insights and expertise to provide information to businesses of the recommended next strategic moves.
Small and medium businesses are a base of Bulgarian economy. In 2022, there have been more than 338.000 SMBs operating in Bulgaria, boosting local economy and creating more job opportunities. According to the global consulting firm McKinsey & Company, digitalization will play an important role in supporting and enabling the CEE economic model transformation. Adoption and taking advantage of digital tools and solutions can become the next growth engine for Bulgaria and can provide an opportunity for businesses to reach new customers and expand into regional and global markets. Thus, Microsoft and its partners launched a Solution Assessment Program for Bulgarian SMB to help them on their digital transformation journey.
Microsoft Solution Assessment program combines highly skilled partners and modern technology to deliver deep organizational insights to make informed IT decisions aligned to business strategy. The program covers such areas as Workforce Productivity, IT Security, Cloud Migration, Modernize Applications, Sustainability, Business Applications, and others. Data-driven recommendations will help SMBs to determine actionable steps for digital transformations, cloud migrations and process improvement.
What will Bulgarian Businesses receive from a Solution Assessment program?
The process of Solution Assessment Program is fully funded by Microsoft and takes up to 5 weeks. Each selected company's assessment will slightly differ, depending on available information, infrastructure, and requirements. The Microsoft Solution Assessment partner will support selected businesses through each phase of the engagement to ensure an effective and smooth process that delivers insights required for the business need.
At the end of the program Bulgarian SMBs will have an opportunity to receive the following outcomes:
Comprehensive overview of the IT estate
Highlighted risks and recommendations for improvement
Total Cost of Ownership (on Prem vs cloud)
Migration roadmap (where applicable)
Once completing the program, the businesses will have an opportunity to be benefit from reduced costs by making more informed decisions, executing on cloud migrations tailored to unique business situation, and migrate to the cyber protected cloud confidently with expert help along the way.
How to nominate Your company for the program?
Bulgarian SMBs that have already been considering the digital transformation as a key driver for their future growth, but still are not sure where to start from, are welcomed to apply for the program via following link: Solution Assessment Program (microsoft.com). Once the nomination is received, it will be reviewed and approved by Microsoft team. If the nomination fulfills the criteria, the applicant will be reached out by a Solution Assessment expert.
From leveraging the cloud as a platform for implementing the best business practices to strengthening business' security infrastructure, Solution Assessment program can help Bulgarian business to plan digital transformation and achieve their business goals. Microsoft is here to help Bulgarian businesses to deliver better process and cost transparency, improve IT services, and ensure alignment with business objectives. Built on a foundation of trust, Microsoft's mission is to empower every organization on the planet to achieve more.
More about the entire process of the "Solution Assessment" program can be found here.
https://eus-streaming-video-rt-microsoft-com.akamaized.net/957ce536-2e35-4051-b502-fc24c7245444/46f632d1-1035-43d8-80ec-66224de4_6750.mp4
Tags: Microsoft Bulgaria, Press Release, SMBs, Solution Assessment Program
Wartime banking: serving citizens and the Ukrainian economy
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Be warned, ice cream tests positive for coronavirus in China
Home›News Now›'They Don't Care About Black People Dying In The Bush'
'They Don't Care About Black People Dying In The Bush'
By alternativeafrica
This article is part of HuffPost's Project Zero campaign, a yearlong series on neglected tropical diseases and efforts to fight them.KISANGANI, Congo ― To save people from a deadly smallpox-like virus that appears on the United States bioterrorism list and once spread from the African bush to the American Midwest, Dr. Anne Laudisoit spends much of her time scaling tall trees in Congolese forests to spy on squirrels.
The 38-year-old biologist also dissects deceased rats, bats and antelopes, and meets people covered in pustulous rashes ― all in the hope of tracing the main animal culprits spreading monkeypox, a painful and contagious virus that has no vaccine and is not well understood.
"That's my work, finding the reservoir or reservoirs of this virus," said Laudisoit, who grew up in a small village in Belgium and came to Congo in 2004 to track plague-carrying rats.
For the past seven years, Laudisoit's team has traveled huge distances on their mission to identify more than a dozen possible monkeypox carriers. They track critters. They track infected people. If a bushmeat hunter kills an animal and the carcass tests positive for monkeypox, Laudisoit's team is on it.
"I'm not afraid ― you just need to be careful where you work," she said, standing among frames of squashed squirrels, stuffed rodents and monkey skulls at the Centre for Biodiversity at the University of Kisangani, in the Democratic Republic of Congo's third largest city.
But when a virus is so overlooked that it doesn't even appear on the World Health Organization's list of neglected diseases, trying to raise awareness means visiting areas where few Westerners have come before ― except to plunder resources.
"If you're a white person and you come sailing down the river in a dugout canoe for four days and trekking through the forest, people think you're coming for diamonds and gold," Laudisoit said.
Far from seeking Congo's riches, she is looking for the origin of monkeypox. The disease was named in 1958 after it was discovered in laboratory monkeys brought from Asia to Denmark, but it originated in the forests that Laudisoit now roams.
Monkeypox was traced to Congo in 1970, when it was first found in humans. It initially causes fever, headache, muscle aches and exhaustion, and later painful lesions that blister, scab and can cause fatal infections usually from septicemia, especially in people with weak immune systems.
The virus is now known to be found in remote tropical rainforests and in 10 or so west and central African countries. And it could be spreading on the back of one of mankind's greatest public health successes ― the eradication of smallpox.
In 1980, after some 3,000 years and hundreds of millions of deaths, the world celebrated the global eradication of smallpox, a virus with a 30 percent mortality rate. It was, and remains, the only human infectious disease to be wiped from the planet. But that achievement also meant an end to smallpox inoculations.
In Congo, home to more than 80 million people, the loss of the smallpox vaccine ― which provides up to 85 percent immunity against monkeypox ― has led to "an increase in cases, primarily among young people, because the herd immunity is going down," Laudisoit said.
According to Laudisoit, there were just under 50 cases of monkeypox in the 1970s. Now, some areas report more than 250 cases each year. And it's not an isolated problem. Of the total 516 health zones that Congo's Ministry of Health monitors, 216 have reported at least one case of monkeypox.
"Almost half a country that is four times as big as France is at risk of developing a disease like smallpox," she said.
Laudisoit often goes to events held by international health organizations to share her knowledge and concerns about monkeypox. She says she sees the same apathy toward this virus as there once was toward Ebola, which was discovered in Congo in the 1970s.
"They don't care about black people dying in the bush," Laudisoit said. "They knew about Zika for 70 years in Uganda ― but when it affects Olympic Games and golfers, then they care."
"At conferences, I ask, 'If a place as big as France, Spain, Belgium and the Netherlands combined had a case of something like smallpox, wouldn't we have already reacted and already revaccinated people?' You've got to ask, because that's exactly what's happening here."
Research into monkeypox is so minimal that Laudisoit's team ― going village to village to record cases and train medics in how to identify the rash ― has cast doubt on existing data. For instance, the World Health Organization estimates that the virus kills between 1 and 10 percent of victims during an outbreak. But Laudisoit and her team have documented mortality rates that are much higher.
"The figures are completely obsolete because there are no recent studies," she said. "Last year, I investigated an epidemic. We went to a village where there were 61 cases, and 12 deaths" ― almost double the stated mortality rate.
There had been little interest in funding research and vaccines for monkeypox until a 2003 outbreak in the U.S. caused by African giant pouched rats imported from Ghana to Texas.
The virus spread from the rats to native prairie dogs at an Illinois pet dealership to more than 70 people across Illinois, Wisconsin, Indiana, Missouri, Kansas and Ohio.
No one died from these first human monkeypox infections outside Africa, and the virus was quickly contained.
But "it could have been a different story," Laudisoit thinks, had the U.S. been hit by the much more virulent Central African strain, which comes from Congo and which, unlike its West African cousin, can kill humans.
Still, the outbreak resulted in the U.S. tightening restrictions on animals imported from Africa. And the Centers for Disease Control and Prevention ― which lists the Central African strain of monkeypox alongside anthrax, SARS and Ebola as a potential bioweapon ― sent teams to places like Congo to search for the virus.
But while CDC teams focus their efforts on human cases, Laudisoit says she and her team "are interested in finding the animal reservoirs." She wants to see more collaboration between virologists, medics and biologists to crack this disease, which, like Ebola and Zika, could mutate, find new hosts and travel farther to infect more people.
Dr. Jean-Jacques Muyembe ― a top Congolese virologist who treated the first known Ebola cases and helped work on a vaccine that was ignored until the virus hit the U.S. ― is still warning developed countries about overlooked diseases that are increasingly spreading.
"These neglected diseases can become a threat to developed countries," Muyembe said. "With travel and everything we have now, the world has become a village."
"Everything comes from animals," he added, "and [Congo's] ecology is one that favors the emergence of these new diseases."
While smallpox could be eradicated because it only existed in humans, "monkeypox probably has 10 or so animal reservoirs," Laudisoit said. "So we need a vaccine, because we can't exactly kill all the animals."
This year, the CDC, in partnership with the Kinshasa School of Public Health and Congo's Ministry of Health, started trials with an injectable vaccine on some 1,000 Congolese health workers in Tshuapa province and some lab workers in the capital.
"Our big push now is trying to get health care workers protected against this," said Benjamin Munroe, a monkeypox specialist at the CDC.
Munroe has seen a resurgence of monkeypox cases in the last couple of years, citing Sierra Leone and the Central African Republic as examples of where more cases are being reported. But he's not worried about a global pandemic.
"I don't think monkeypox will become a mutant, rampant virus and take over the world," he said. "And if it were to, we already have strategies and vaccines from eradicating smallpox. You can pull out that playbook, dust it off and do it again if you had to."
But rolling out a new and expensive monkeypox vaccine to all those at risk would require serious international funding for something that's considered a disease of poverty, Munroe noted.
"Incredibly poor people who are forced into the forest to subsist on what they can are the people we see getting these diseases," he said.
And Laudisoit sees little hope on the horizon for them.
"For as long as there's not a white person who has monkeypox ― with spots like in the '60s from smallpox ― there will be a lack of money," she said. "I assure you that when that happens, within three days, there will be funding, and that's true for all neglected diseases."
This series is supported, in part, by funding from the Bill & Melinda Gates Foundation. All content is editorially independent, with no influence or input from the foundation. If you'd like to contribute a post to the series, send an email to ProjectZero@huffingtonpost.com. And follow the conversation on social media by using the hashtag #ProjectZero.
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"Thank God I am leaving the hospital in good health and I will return to work tomorrow," the 82-year-old leader said.
RAMALLAH, West Bank - Palestinian Authority President Mahmoud Abbas was released from the hospital on Monday after an eight-day stay and treatment for what officials said was a lung infection.
"Thank God I am leaving the hospital in good health and I will return to work tomorrow," the 82-year-old leader, dressed in a suit and smiling, told reporters before walking out of the hospital in the city of Ramallah in the West Bank.
Abbas, who is a heavy smoker, was admitted on May 20 for what doctors had initially said were medical tests following ear surgery. Officials later said he was being treated for pneumonia.
Abbas, who was also hospitalized for medical checks during a trip to address the UN Security Council in February, became president after the death in 2004 of Yasser Arafat.
The Western-backed president pursued US-led peace talks with Israel but these broke down in 2014 and his democratic mandate expired eight years ago.
There has been no Palestinian presidential election since 2005, and the term of office is only five years. Abbas's authority is essentially limited to the West Bank, with the Islamist group Hamas in control of the Gaza Strip.


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text:
Toll-like receptor polymorphisms and rheumatoid arthritis: A systematic review
Young Ho Lee, Sang Cheol Bae, Jae Hoon Kim, Gwan Gyu Song
The aim of this study was to determine whether toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis (RA) and influence the clinical characteristics of RA. The authors conducted a systematic review on associations between TLR polymorphisms and RA susceptibility and clinical findings. Meta-analysis was performed if at least three comparisons of an issue were available. A total of 14 studies were included in this systematic review, which included European and Asian studies. Meta-analysis of five European studies showed no association between the TLR4 Asp299Gly (rs4986790) polymorphism and RA (OR for the minor allele = 0.907, 95 % CI = 0.755-1.088, p = 0.291). Furthermore, none of these studies found any association between the polymorphism and clinical characteristics. A significant difference between TLR9 rs187084 allele frequencies in RA patients and controls was found in one Turkish study (p = 0.003), and a moderate association between RF positivity and TLR8 rs5741883 was found in an European study (p = 0.001). The numbers of guanine-thymine [(GT)n] repeats in intron II of the TLR2 gene were found a significantly higher S-allele frequency in Korean patients with RA than in controls (30.3 vs. 23.0 %, p = 0.03). This meta-analysis shows lack of an association between the TLR4 Asp299Gly polymorphism and RA. However, our finding suggests the possibility that TLR polymorphisms are associated with the development and clinical characteristics of RA. Because of a paucity of data of the TLR polymorphisms, case-control studies are required to determine whether TLR2, 4, 8, 9 polymorphisms contribute to RA susceptibility or severity in more than 2,000 patients and controls.
Rheumatology International
Toll-like receptor
Dive into the research topics of 'Toll-like receptor polymorphisms and rheumatoid arthritis: A systematic review'. Together they form a unique fingerprint.
Toll-Like Receptors Medicine & Life Sciences 100%
Rheumatoid Arthritis Medicine & Life Sciences 75%
Meta-Analysis Medicine & Life Sciences 22%
Gene Frequency Medicine & Life Sciences 19%
Thymine Medicine & Life Sciences 13%
Guanine Medicine & Life Sciences 12%
Introns Medicine & Life Sciences 9%
Lee, Y. H., Bae, S. C., Kim, J. H., & Song, G. G. (2014). Toll-like receptor polymorphisms and rheumatoid arthritis: A systematic review. Rheumatology International, 34(1), 111-116. https://doi.org/10.1007/s00296-013-2666-7
Toll-like receptor polymorphisms and rheumatoid arthritis : A systematic review. / Lee, Young Ho; Bae, Sang Cheol; Kim, Jae Hoon et al.
In: Rheumatology International, Vol. 34, No. 1, 01.2014, p. 111-116.
Lee, YH, Bae, SC, Kim, JH & Song, GG 2014, 'Toll-like receptor polymorphisms and rheumatoid arthritis: A systematic review', Rheumatology International, vol. 34, no. 1, pp. 111-116. https://doi.org/10.1007/s00296-013-2666-7
Lee YH, Bae SC, Kim JH, Song GG. Toll-like receptor polymorphisms and rheumatoid arthritis: A systematic review. Rheumatology International. 2014 Jan;34(1):111-116. doi: 10.1007/s00296-013-2666-7
Lee, Young Ho ; Bae, Sang Cheol ; Kim, Jae Hoon et al. / Toll-like receptor polymorphisms and rheumatoid arthritis : A systematic review. In: Rheumatology International. 2014 ; Vol. 34, No. 1. pp. 111-116.
@article{ec82acd4fed04b85b77c751fc723eae7,
title = "Toll-like receptor polymorphisms and rheumatoid arthritis: A systematic review",
abstract = "The aim of this study was to determine whether toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis (RA) and influence the clinical characteristics of RA. The authors conducted a systematic review on associations between TLR polymorphisms and RA susceptibility and clinical findings. Meta-analysis was performed if at least three comparisons of an issue were available. A total of 14 studies were included in this systematic review, which included European and Asian studies. Meta-analysis of five European studies showed no association between the TLR4 Asp299Gly (rs4986790) polymorphism and RA (OR for the minor allele = 0.907, 95 % CI = 0.755-1.088, p = 0.291). Furthermore, none of these studies found any association between the polymorphism and clinical characteristics. A significant difference between TLR9 rs187084 allele frequencies in RA patients and controls was found in one Turkish study (p = 0.003), and a moderate association between RF positivity and TLR8 rs5741883 was found in an European study (p = 0.001). The numbers of guanine-thymine [(GT)n] repeats in intron II of the TLR2 gene were found a significantly higher S-allele frequency in Korean patients with RA than in controls (30.3 vs. 23.0 %, p = 0.03). This meta-analysis shows lack of an association between the TLR4 Asp299Gly polymorphism and RA. However, our finding suggests the possibility that TLR polymorphisms are associated with the development and clinical characteristics of RA. Because of a paucity of data of the TLR polymorphisms, case-control studies are required to determine whether TLR2, 4, 8, 9 polymorphisms contribute to RA susceptibility or severity in more than 2,000 patients and controls.",
keywords = "Polymorphism, Rheumatoid arthritis, Systematic review, Toll-like receptor",
author = "Lee, {Young Ho} and Bae, {Sang Cheol} and Kim, {Jae Hoon} and Song, {Gwan Gyu}",
note = "Funding Information: Acknowledgments This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).",
journal = "Rheumatology International",
T1 - Toll-like receptor polymorphisms and rheumatoid arthritis
AU - Lee, Young Ho
AU - Bae, Sang Cheol
AU - Kim, Jae Hoon
AU - Song, Gwan Gyu
N1 - Funding Information: Acknowledgments This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065).
N2 - The aim of this study was to determine whether toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis (RA) and influence the clinical characteristics of RA. The authors conducted a systematic review on associations between TLR polymorphisms and RA susceptibility and clinical findings. Meta-analysis was performed if at least three comparisons of an issue were available. A total of 14 studies were included in this systematic review, which included European and Asian studies. Meta-analysis of five European studies showed no association between the TLR4 Asp299Gly (rs4986790) polymorphism and RA (OR for the minor allele = 0.907, 95 % CI = 0.755-1.088, p = 0.291). Furthermore, none of these studies found any association between the polymorphism and clinical characteristics. A significant difference between TLR9 rs187084 allele frequencies in RA patients and controls was found in one Turkish study (p = 0.003), and a moderate association between RF positivity and TLR8 rs5741883 was found in an European study (p = 0.001). The numbers of guanine-thymine [(GT)n] repeats in intron II of the TLR2 gene were found a significantly higher S-allele frequency in Korean patients with RA than in controls (30.3 vs. 23.0 %, p = 0.03). This meta-analysis shows lack of an association between the TLR4 Asp299Gly polymorphism and RA. However, our finding suggests the possibility that TLR polymorphisms are associated with the development and clinical characteristics of RA. Because of a paucity of data of the TLR polymorphisms, case-control studies are required to determine whether TLR2, 4, 8, 9 polymorphisms contribute to RA susceptibility or severity in more than 2,000 patients and controls.
AB - The aim of this study was to determine whether toll-like receptor (TLR) polymorphisms confer susceptibility to rheumatoid arthritis (RA) and influence the clinical characteristics of RA. The authors conducted a systematic review on associations between TLR polymorphisms and RA susceptibility and clinical findings. Meta-analysis was performed if at least three comparisons of an issue were available. A total of 14 studies were included in this systematic review, which included European and Asian studies. Meta-analysis of five European studies showed no association between the TLR4 Asp299Gly (rs4986790) polymorphism and RA (OR for the minor allele = 0.907, 95 % CI = 0.755-1.088, p = 0.291). Furthermore, none of these studies found any association between the polymorphism and clinical characteristics. A significant difference between TLR9 rs187084 allele frequencies in RA patients and controls was found in one Turkish study (p = 0.003), and a moderate association between RF positivity and TLR8 rs5741883 was found in an European study (p = 0.001). The numbers of guanine-thymine [(GT)n] repeats in intron II of the TLR2 gene were found a significantly higher S-allele frequency in Korean patients with RA than in controls (30.3 vs. 23.0 %, p = 0.03). This meta-analysis shows lack of an association between the TLR4 Asp299Gly polymorphism and RA. However, our finding suggests the possibility that TLR polymorphisms are associated with the development and clinical characteristics of RA. Because of a paucity of data of the TLR polymorphisms, case-control studies are required to determine whether TLR2, 4, 8, 9 polymorphisms contribute to RA susceptibility or severity in more than 2,000 patients and controls.
KW - Polymorphism
KW - Rheumatoid arthritis
KW - Toll-like receptor
JO - Rheumatology International
JF - Rheumatology International


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"MAXIMALISM - 5555 years passed: subconsciousness, Darkness filled the boundless all, The night of the hunted begins", solo show @ artespace LessingEINS, Zürich, 2011 (...)
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"<+$+> Part II, Die Säule, der Monolith, das Spektrum, tiefschwarz, doppelt geköpft (thx-giving)", group show @ Helmhaus, Werk- und Atelierstipendien der Stadt Zürich, 2011 (...)
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"ungesehen und unerhört - Künstler reagieren auf die Sammlung Prinzhorn / Quadrabble", group show @ Sammlung Prinzhorn, Heidelberg, Germany, 2010 (...)
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"Basement Projects I / Veal tongue, Poppopel", group show @ Museum Bärengasse, Zürich, 2010(...)
"A new formalism / A selection of the U5 archive", group show @ Art Fair Dubai / Bidoun Projects, 2010 (...)
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Letter Writing Time Again
The Devils Lake Water Improvement District and its Board of Directors has spent the past few months working to bring grass carp back to Devils Lake. We are nearing the finish line and it's time to ask for your help once again. Please take the time to draft a letter to the Oregon Department of Fish and Wildlife Commission (ODFW) based on the instructions below to voice your support of the reintroduction of grass carp in Devils Lake. Here's an update on our progress, followed by our letter writing request.
The District is pursuing a permit under OAR 635-056-0075(2) from the Oregon Department of Fish and Wildlife to re-introduce sterile grass carp into Devils Lake. In furtherance of this goal the District has submitted a permit application which also serves as its management plan setting forth the timelines, policies, and processes that will be used for the re-introduction and ongoing management of grass carp in Devils Lake. In order for our permit to be processed certain changes to the Oregon Administrative Rules (OAR's) pertaining to grass carp are required.
We have been working extensively with ODFW staff to draft the required rule changes. Once finalized, these draft rule changes will be presented to the ODFW Commission in February with a recommendation from staff for approval. The District is optimistic that these rules will be approved leading to the successful placement of grass carp in late spring of 2023.
We have been assured that the ODFW Commission will place this issue on its agenda for their meeting held February 16th and 17th, 2023. Our attorney Sarah Stauffer-Curtiss from Stoel Rives will be making comments on behalf of the lake. We are not recommending that our public attend this meeting as we feel it will be more effective for the Commission to hear our support for the rule change via written submissions.
This is where you come in. We have created a template for the Commission and we would request everybody forward it to the ODFW Commissioners. All letters must arrive at least 48 hours prior to the meeting, so the due date for this request is February 14th, 2023. Does it really do any good for each of them to receive a couple hundred of the same letter? Indeed it does.
Here's what to do by February 14, 2023
Download the letter from this link. (WORD) (PDF)
Optionally edit the letter to include your name and address.
Send the letter as an attachment by email, feel free to add a few photos if you wish. You can add a more personal message in the body of the email or modify the 4th paragraph to describe how the elodea invasion has affected you directly.
Send the email to [email protected]
Let us know you did it by completing a brief questionnaire
posted by Mitchell Moore | 297.20sc
1 comment Share
Fall Harvesting (Video)
New Devils Lake Strategic Plan
The Devil's Lake Water Improvement District Board of Directors approved a new strategic plan for Devil's Lake at its October meeting. The entire text can be found at this link. Here are some of the highlights.
At its core the new strategic plan is based on the District's mission and four main goals.
The District is authorized to direct a range of initiatives, programs, and actions to achieve the restoration, maintenance, and enhancement of Devils Lake. These responsibilities can be grouped under four general areas, which form the District's core mission: water supply, water quality, natural systems, and public access. The District has established goals for each of these areas of responsibility:
Water Supply Goal: Ensure the proper supply and level of water in Devils Lake to provide for all existing and future reasonable and beneficial uses while protecting and maintaining water resources and related natural systems.
Water Quality Goal: Protect and improve water quality to sustain the water resources, environment, economy, and quality of life.
Natural Systems Goal: Preserve, protect, and restore natural systems to support their natural hydrologic and ecologic functions and improve the environment for fish, wildlife, and humans in Devils Lake and its watershed.
Public Access Goal: Improve and maintain public access and awareness, safe and efficient navigation, and recreational opportunities in and on Devils Lake
The District is implementing a wide array of programs and projects to meet these four goals. These activities are grouped under 7 Strategic Initiatives:
Minimum Flows and Levels Establishment and Monitoring
Water Quality Assessment and Planning
Water Quality Maintenance and Improvement
Aeration and Oxygen Level Improvement and Monitoring
Mitigation of Submerged Aquatic Vegetation Infestation
Public Access, Marina, and Community Outreach
Each of these strategic initiatives is described in detail in the plan document. Upon approval the Board discussed how this plan will require review and possible modification as required by the impact it has on the lake environment. This review will occur annually.
Ballot Measure 22-213
The Devils Lake Neighborhood Association cannot and does not take a position in any election. We do however try to help keep our neighbors aware of important issues that impact the neighborhood.
On November 8, 2022, voters will be asked whether to approve an increase in property taxes for the next five years for the Devils Lake Water Improvement District (DLWID). If approved, funds will be used to continue District operations, which includes vegetation management, water quality testing, district operations, and special projects.
According to the 2022 General Election Voters Pamphlet the tax revenue from this measure would allow the Devils Lake Water Improvement District to continue its vegetation management program. Programs to be funded annually by the revenue include approximately $200,000 for targeted herbicide treatments, $50,000 for mechanical harvesting and disposal, and $67,000 for re-stocking and managing grass carp in Devils Lake. The district has in their operating budget monies for vegetation management, this additional levy is what the district needs to control the vegetation at its current level.
Given the clear history of rapid aquatic vegetation overgrowth in Devils Lake, vegetation management has become our key priority. Our district completed a successful treatment project which improved several acres of the Lake. However, this treatment only covered a limited amount of invasive milfoil eradication. Since the 2019 project, our waters have taken a major turn. A very prolific submerged plant has all but overtaken Devils Lake. In under 18 months what was very sparse vegetation has exploded to cover very large expanses of our waterbody. If the growth continues at this rate the lake will soon become non-navigable and negative impacts to fish and wildlife will increase. The district has begun a pilot targeted herbicide application program and is working with State Fish and Wildlife officials to reintroduce sterile grass carp as control methods. Additionally, a mechanical harvester has been contracted to work on the Lake to maintain navigability. Due to the cost of these management options additional funding is necessary to continue managing the vegetation overgrowth in Devils Lake.
The levy is $.2499 (In-Watershed) and $.128 (Outside-Watershed) per $1,000 of assessed property value. At the $.2499 rate a home valued at $300,000 would pay $75 per year or less. At the $.128 rate a home valued at $300,000 would pay $39 per year or less.
Harvesting 2.0
If you have been following our updates you know we have recently completed three weeks of mechanical harvesting on Devils Lake. The main goal of that project was to gain on lake experience with harvesting while removing as much elodea as we could. In the meantime, the condition of the lake has evolved with large masses of plant material floating to the surface eventually gathering in various locations around the lake.
We have learned from our research that this calving is part of the elodea's survival strategy. These large mats eventually sink to the bottom where they overwinter and emerge next spring as a new population of plants. In the meantime, they act as a nearly impenetrable "reef" of material that can stop a boat in its tracks. Normally our wind patterns would deposit nearly all of this material on the Southern shore but this has been an unusual fall with winds blowing from the North, South, and East. This has resulted in elodea rafts being deposited all over the lake, with highest concentrations still on our Southern shoreline.
Faced with this reality the Devils Lake Water Improvement District board has located a second harvesting company with a machine available for use in Devils Lake. The District was able to procure a harvester and a crew to operate it out of the bay area in California from Aquatic Harvesting Inc. They will be arriving September 19th and operating the harvester on our lake for up to a month. This is a different machine than the one we had on the lake in August with a 8 foot wide cutter, a cutting depth of 6 feet and a much larger capacity to store cut weeds. It also is better equipped for unloading the material on the shore once cut.
The goal of this second project is to remove as much material as possible from the lake. If these rafts of elodea effectively are the seeds of next year's weeds we want to get as much of that out of the lake as possible in hopes that it will slow the expansion of this infestation.
This project has come together quickly and is truly a community effort. Several of our local businesses are assisting the District in getting this off the ground. Our sincere appreciation goes out to North Lincoln Sanitary Service, Sexton Construction, and Whistler Construction for their invaluable help. We will also need volunteer help from our community, please consider raising your hand for the effort. If you know of anyone that we can put on the list to volunteer to operate an excavator to load the dump trailers, transport the dump trailers to the dumping location and return the dump trailers to the lake loading site, or if you're willing to occasionally help clean up our offload sites please let us know.
Harvesting is an expensive proposition and the Devils Lake Neighborhood Association has solicited and collected many donations to fund our first project. This second project will be primarily funded by the Devils Lake Water Improvement District who help fund the DLNA project. Our remaining harvesting funds will be forwarded to the District to help fund this important project. We are still accepting donations, so if you made a donation and still want to help or if you committed to a donation and are not sure where to make the payment you can follow this link or the button in the sidebar. All harvester donations will be forwarded to the District to help defer the cost of operations over the next month.
Additionally, the District is working out the details of relocating a harvester owned by Aquatic Harvesting Inc. to Devils Lake which will be its permanent home for the next 4-5 years. This machine includes a barge that connects to the harvester making the offloading task more efficient. This will guarantee we have a harvester on the lake next spring to begin removing the new growth as it appears. Harvesting represents an important component of the District's vegetation management plan which also includes herbicide and the eventual reintroduction of grass carp in the lake.
Thank you all for your participation in this season's harvesting projects. This is all new to our community but we have gained some valuable experience and hopefully began to reduce the weed population in Devils Lake.
Carp Update September 1, 2022
Back in July the Devil's Lake Neighborhood Association asked all of you to write letters to a variety of decision makers. The community responded and many letters were sent. As a result, people who work in the State government quickly became aware of the weed problem on Devil's Lake. Mission accomplished. Thank you for your grassroots efforts.
The Devils Lake Neighborhood Association and Devils Lake Water Improvement District invited many individuals from the Oregon Department of Fish and Wildlife, State Legislators, County Commissioners and local government officials to come join us for a tour to see the condition of the lake in person. It was a nice day yet only Representative David Gomberg and Senator Dick Anderson joined us. There were no other attendees. It was, however, a worthwhile event as Representative Gomberg was making phone calls before he even left the boat.
On August 5th, Josh Brainard DLWID Lake Manager appeared briefly before the ODFW Commission at their meeting in Salem. He explained our situation during the three minutes allotted to individuals during the public comment portion of the meeting.
Subsequently, a few meetings have occurred between ODFW staff and the Devils Lake Water Improvement District. In these meetings we learned that it is ODFW staff's position that the Commission's existing ability to waive certain restrictions related to grass carp would not be sufficient for placement of fish on Devils Lake. It is their position that it will take an Oregon Administrative Rule (OAR) change to allow the eventual restocking of fish on Devils Lake.
With that position in mind ODFW staff delivered a draft position paper as well as draft proposed changes to the Oregon Administrative Rules pertaining to the placement of sterile grass carp on Devils Lake. Our review found some of the rules to be simply unworkable. However, subsequent conversations have resulted in a commitment to remove or modify most of the objectionable wording. At this time, the greatest outstanding issue is the discrepancy between the State and DLWID over the number of carp they will allow to be placed. Negotiations continue.
The process of making these Administrative Rule Changes is specified in Oregon statutes. Therefore the timeline is dictated by the steps required by Oregon law. Much of the timeline related to this process is to provide ample time for interested parties to become aware of the ruling and comment if they so desire. Our goal is to win approval for placement in the spring. Draft OAR changes will be taking place over the next several weeks. Both parties feel that all changes should be completed and ready for the ODFW Commission's final approval at their January 2023 meeting. If so, this would represent a very quick turn around, so don't be surprised if this timeline expands some prior to completion.
Does this mean we are going to get approval for grass carp? That's impossible to say, but so far we are pointing more toward a positive result than failure. In the meantime, patience is required as this will not happen overnight.
Harvesting Lessons Learned
During the last five weeks we have completed three weeks of harvesting on Devil's Lake. We wish to thank all of you who made donations to make this learning experience possible. If you have committed to a donation and wish to complete it follow this link.
The main purpose of this project was to gain on lake experience to be used in planning of future harvesting activities and hopefully provide a little relief to the current situation. In the near term harvesting will be part of Devils Lake Water Improvement District's (DLWID) three prong approach to vegetation management. The plan also includes application of herbicides and restocking sterile grass carp in Devils Lake. Here's a summary of what we've learned in the harvesting project.
Overwhelming Volume
During our 3 weeks of harvesting we removed 41.5 tons of elodea from the lake. That's 83,000 lbs!
Massive amounts of elodea suddenly appeared in Devils Lake between 2021 and 2022; a plant that was virtually non-existent in the lake two years earlier. To better understand the current situation the Devils Lake Neighborhood Association (DLNA) has funded an engineering survey of the weeds in the lake to document the physical weed coverage of the lake. This survey will provide the DLWID with information that should help the establish the extent of the weeds within the lake and the volume of weeds in the lake. This information will be useful to the DLWID and the ODFW in their discussion as to the appropriate number of sterile carp that hopefully will be approved for re-introduction into the lake at a future date.
Expectations Exceeded Reality
Our harvesting efforts resulted in a tremendous amount of material being removed from the lake. Depending on where you are on the lake the harvesting results vary. The weeds were so thick on the West end we spent a full week just trying to clear a path in front of the docs on the South shore. Because of our prevailing winds within a week more plant material floated across the lake through our clearing and stacked up against the South shore. On the North shore the harvester fared better.
When operating the harvester collects 90% of what it grabs. In the days that follow, bits of elodea that remained in the harvested area eventually break off and float with the wind. This material floats away from the North shore heading across the lake to the South. This phenomenon would continue for a couple of days after the harvester passed.
We had some success in creating channels by removing the first four feet of elodea making the areas somewhat passable by a boat. Unfortunately as the weeks progressed materials continued to drift South overwhelming the recently created channel on the South shore. The North shore channel seemed to remain somewhat intact.
Effort Frustrated by Elodea's Life Cycle
Our project dates were limited given that we were well into the season when we found an available lake harvester. Our harvesting project completed about the same time that elodea begins its fall shedding. So by mid-August we began to see large floating mats of elodea on the lake. These are not remnants of the harvesting but rather part of the natural life cycle of elodea. Each year the plants shed large sections into the water column in preparation for a second growing season in the fall. These floating mats are a key part of the plant's reproductive strategy, floating off, eventually sinking to the bottom and root in a new location.
If you live on the South shore you're absolutely overwhelmed by large tangled floating islands of weeds. Some are so dense that you will see ducks hitching a ride. Currently, homeowners on the South shores can clear their shoreline one day only to return to see thick dense weeds solid from bottom to surface within days. This is a huge problem that requires a solution.
Timing May Be Everything
As a community I think we were all surprised, perhaps shocked when we looked in the water this spring. Elodea was everywhere! Due to the relative lack of weeds in the preceding years there were no plans in May to have a harvester arrive at Devils Lake. That's when DLNA attempted to find a harvester and schedule some time on the lake. Initially we received a one week commitment. We were able to extend that commitment to 3 weeks.
Upon initial review it appears the best approach to harvesting in the future would be to begin a few weeks early in May to knock down a channel around the perimeter of the lake. Then return in late August to remove the floating mats of weeds that appear when the plants are sheading.
It's important to remember that the primary reason for using a harvester as well as herbicide is to reduce the volume of weeds in the lake. We want to give our future grass carp, if approved, a chance to have an impact earlier in their life cycle. This revised schedule should maximize the volume of material that could be removed and hopefully accelerate the lake's recovery.
A Different Model
It appears that for at least the next 5 years harvesting activities will be a part of our lake. Ongoing harvesting will likely be done under contract to the Devils Lake Water Improvement District. We suggest the District fund the spring and fall harvesting projects. Perhaps during the interceding time individuals could independently contract with a harvester willing to come to the lake to work their individual properties.
Removal and Disposal
One of the biggest challenges in harvesting Devils Lake is setting up dump sites and removing the weeds from the site. This season we relied heavily on the generosity and expertise of North Lincoln Sanitary Service who helped stage drop boxes and backhoes in various locations as the harvesting progressed. We were able to use some public access points such as the boat ramps and a few homeowners gave us access to their lakefront. Some sites worked better than others. We learned drop boxes work but dump trailers may be a better solution as they're more readily accessible to the shoreline. We also need to find better methods of pulling the weeds out of the lake and putting them in the trailer. The 41 tons of material was hauled to North Lincoln Sanitary Service where it was laid out to dry. It was then gathered up and trucked out for composting. Our activities at shoreline dump sites made a bit of a mess and many of you volunteered to clean up these sites at the end of each day. Thank you all for your assistance.
A Learning Experience
Again we wish to thank all who participated in this project. It provided us with valuable information. The information we learned will be incorporated in the Devils Lake Carp Management Plan which will be a requirement of any permit granted by the Oregon Department of Fish and Wildlife. Next year ongoing harvesting activities will benefit from the knowledge gained.
Elodea Lifecycle
Elodea canadensis is a submerged aquatic plant of slower flowing rivers and lakes, native to North America. It has been intentionally introduced into areas outside of its native range as an ornamental aquarium species. This species has a wide ecological tolerance and grows relatively fast. It is a perennial, overwintering in the deeper water, and reproducing asexually. Disturbance increases the dispersal of numerous buds and the vigorous re-growth is enhanced through changes in availability of nutrients. Elodea canadensis can form dense mats which can interfere with recreational activities, navigation and port infrastructure. In addition to this, the dense mats outcompete native plant species and therefore decrease the biodiversity in an area. It also accentuates the accumulation of finer organic silts which enhances its growth further as nutrients are released. Elodea canadensis originates from North America, concentrated around the St Lawrence Valley and the Great Lakes regions and the Pacific West Coast, but now occurs throughout the US. Elodea canadensis is considered invasive in Australia, New Zealand, Cuba, Alaska. Oregon classifies Elodea canadensis as a native plant.
Elodea male plants are less common than female in its native range. Plants are usually dioecious (individuals bear either male or female flowers only) and produce seeds in ellipsoid or oval capsules. The plants reproduce readily by asexual fragmentation, and many invasive populations consist entirely of individuals of the same sex, having originated from a single, introduced, plant fragment. The main growing season is between mid-April and October. Plants can die back in Autumn but may survive in temperate climates. Turions or short, densely-leaved resistant stems, develop then break off to float around the water body before they sink to the bottom over winter, where they rest until they re-grow in spring.
Over-wintering buds and fragments of the brittle branches are easily detached by waves, currents, foraging animals and boat traffic. New roots develop quickly on the nodes of these fragments which are carried away to form new stands. This method of propagation gives Elodea canadensis a considerable advantage over annual species and resulted in its rapid spread throughout North America.
Survival is by densely-leaved crowded ends or turions. During autumn, turions cease to elongate and come to bear tightly clustered dark green leaves, which contain increased starch and are slightly more waxy than the normal foliage leaves. These turions may be liberated when the parent stems disintegrate and sink to the bottom, or remain attached throughout winter. The turions remain dormant until spring, when the leaves expand, roots develop from the lower nodes, the axis elongates and a new plant is formed. Elodea canadensis begins to grow during the spring season and is well formed by early May.
More detailed information is available at this link.
Patience Please
The few individuals who have volunteered to assist the DLWID in trying to solve this crisis are just homeowners like you. They did not plant elodea in the lake. They do not get paid. They have better ways of spending their time and we are grateful for their assistance.
As the summer rolls on, the DLNA has been fielding emails and comments that draw from frustration and border on nasty. That's not going to help solve this problem. Please, let's keep our discourse civil and continue to work together on solving this problem.
Harvesting Week 1 Completed
Week one of weed harvesting on Devils Lake has come to a close an we removed an astounding 12 tons of weeds from the lake. We got five pretty good days of harvesting in this week but midday on Friday the ECO Harvester suffered a major breakdown. One of the large steel rollers for the main belt drive failed. You can see from the image something's very wrong. Unfortunately the repair couldn't be done in Lincoln City so the machine is headed back to its home port in Coos Bay.
Overall the harvesting cut a tremendous amount of material out of the lake, as measured in tons! Western Shoreline Restoration will be back on August 15th for two more weeks of harvesting on Devil's Lake. Overall we learned a tremendous amount of information about what to expect in a harvesting project. More than anything we learned just how dense the Elodea is in some areas especially the West end of the lake. We are learning about what to expect in terms of daily progress. We're learning about what's required in terms of staging drop boxes and excavators. We learned that no matter how much we take out the lake just keeps on giving.
Take Action Volunteer Make a Donation


Discussion in 'ten-forward' started by Mr.Blaze, May 5, 2003.
Sounds like a hardware prob. Did the BSOD mention anything about a VxD or any other hints to what exactly was wrong?
Got it all figured out then?
You mean these: http://download.microsoft.com/download/vb60pro/Redist/sp5/WIN98Me/EN-US/vbrun60sp5.exe ? Help yourself.
I guess you are talking about Acronis True Image.
At the moment the latest version is 6.0 build 334 from April 21, 2003.
Well, I don't know whether that might solve your prob.


text:
Q: Set multiple div elements to "position: fixed" at the bottom of a page I have 4 div on my page. I want to set those 4 div at bottom, so that those div stay at bottom even when there are scrollbar.
This is my HTML.

1) Lorum Ipsum Dolor Sit Amet

Lorum Ipsum Dolor Sit

Lorum Ipsum Dolor Sit

Lorum Ipsum Dolor Sit

Lorum Ipsum Dolor Sit

Lorum Ipsum Dolor Sit

Lorum Ipsum Dolor Sit

Long Dummy content.

Footer - scroll 1

Footer - scroll2

Footer - scroll 3

Footer - scroll4

And my Css
.footerdiv {
    position: fixed;
    bottom: 0;
    width: 100px;
}

It is setting my div at bottom, But all the bottom div are overlapping.
I want to show them side by side by keeping all 4 div at bottom.
JsFiddle

A: Rather than positioning each element at the bottom, wrap the elements and set the parent element's position to fixed and position it at the bottom.
In doing so, the .footerdiv elements are still in the normal flow, and they can be positioned beside each other.
Updated Example
.footer-container {
  position: fixed;
  left: 0; right: 0;
  bottom: 0;
}
.footer-container .footerdiv {
  display: inline-block;
}

A: You had actually used 4 div's with same DIV id.
This is what you had to do-

Footer - scroll 1

Footer - scroll2

Footer - scroll 3

Footer - scroll4

and set css to 100%, let it take up the horizontal space of the page-
.footerdiv {
    position: fixed;
    bottom: 0;
    width: 100%;
}

Have a look at the working demo on JS fiddle.
Hope it helps :) Happy coding!

A: Set an id for each div and refer to each div that way.

Footer - scroll 1

Footer - scroll2

Footer - scroll 3

Footer - scroll4

Then you can say:
.footerdiv {
    position: fixed;
    bottom: 0;
}
#d1 {
    left: 100px;
}
#d2 {
    left: 200px;
}
#d3 {
    left: 300px;
}

A: How about a table? You can create a new column for each one of your elements.

    Footer - scroll 1
    Footer - scroll 2
    Footer - scroll 3
    Footer - scroll 4

A: You can wrap them in footer like this. Here is fixed version:
https://jsfiddle.net/4dq215h4/2/
and change css to this:
.footerdiv {
background: #0070FF;
line-height: 2;
text-align: center;
color: #042E64;
font-size: 20px;
font-family: sans-serif;
text-shadow: 0 1px 0 #84BAFF;
box-shadow: 0 0 15px #00214B;
display:inline-block;
float:left;
width:100px;
}
footer{
  position:fixed;
  bottom:10px;
}


Lights: WHEN ATCT CLSD ACTVT HIRL RY 17/35; REIL RYS 17 & 35 - CTAF.
Landing fee: yes, RAMP FEE FOR CIVIL ACFT; WAIVED WITH FUEL PURCHASE.
NIXIN 221/32.0 326 05E BVP -... ...- .--.
100LL AVBL 24 HRS SELF SERVE. FOR JET A AFT HRS CALL 281-275-2400 BEFORE 2300.
NITROGEN AVBL DURG BUSINESS HRS.
Elevation: 82.0 ft. 74.3 ft.
Displaced threshold: 380 ft. 1984 ft.
+27 FT RR 90 FT FM THLD ON CNTRLN; +17 FT RD, +30 PLINE.
- NO TOUCH & GO LNDGS AFTER TOWER CLOSES.
- MILITARY AND CORPORATE GND TRANSPORTATION PRVDD.
- NOISE ABATEMENT PROCEDURE: NOISE SENSITIVE AREAS - INFO AVBL AT TERMINAL.
- NO INTERSECTION DEPARTURES FOR MULTI-ENGINE ACFT.
- FOR CD WHEN ATCT IS CLSD CTC HOUSTON APCH AT 281-443-5844 TO CNL IFR AT 281-443-5888.
- SURFACE CONDITIONS NOT REPORTED FRIDAY 10:00 PM - SUNDAY 10:00 PM.
Photo by Joey Fedorchik Photo taken 16-Apr-2014 looking south.
Do you have a better or more recent aerial photo of Sugar Land Regional Airport that you would like to share? If so, please send us your photo.
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A man stole a New York City police vehicle left idling in the Bronx, N.Y., Saturday morning and drove it to LaGuardia Airport, MyFoxNY.com reported.
The police officer allegedly left his vehicle unattended and idling while he grabbed a bite to eat inside a local diner, the New York Post reported.
"All of a sudden I see a cop come out of the restaurant running," Sammy Obaid, who works by the diner, told the New York Post. "He was going crazy. He was on the phone, making calls. He was freaked out."
There was a loaded shotgun inside the vehicle when it was stolen.
The suspect was arrested inside an airport terminal.
Click here for more on this story from MyFoxNY.com.


text:
from unittest import TestCase
from nose.tools import raises
from pprint import pprint  # noqa

from jsonmapping.network import Network
from .util import resolver, fixture_uri, fixture_file, csv_mapper

class NetworkTestCase(TestCase):

    def setUp(self):
        super(NetworkTestCase, self).setUp()
        self.mapping, uri = fixture_uri('everypol/mapping.json')
        resolver.store[uri] = self.mapping
        self.csvobj = fixture_file('everypol/term-26.csv')

    @raises(TypeError)
    def test_require_schema(self):
        network = Network(resolver)
        network.add({})

    def test_sa_term26_mapping(self):
        network = Network(resolver)
        for obj in csv_mapper(self.csvobj, self.mapping, resolver=resolver):
            # pprint(obj)
            network.add(obj)

        d3_data = network.to_dict()
        assert 'nodes' in d3_data, d3_data.keys()
        assert 'links' in d3_data, d3_data.keys()
        assert len(d3_data['links']), d3_data['links']

        # assert False

redpajama_set_name: RedPajamaGithub


Just because the government turns out the lights, shuts down agencies such as the IRS, closes the gates of national parks, and furloughs 800,000 "nonessential" workers doesn't mean taxpayers save money. In fact, it could prove more costly than business as usual – adding hundreds of millions of dollars a day to state and national spending.
For one thing, those workers may be entitled to back pay and will be eligible for unemployment. States will have to shell out money ahead of transfers from Washington. Then there's all the work that will have piled up. When they return, many government employees will have to put in extra time.
A shutdown also can add to the money needed by government agencies, which lose the ability to collect fees on their services. During the government shutdown in 1995, for instance, the national parks lost 7 million visitors, costing the National Park Service an estimated $14 million in tourist revenues. Overall, the Office of Management and Budget estimates the shutdown cost taxpayers around $100 million each day at first – and more than $1 billion after three weeks.
And this isn't counting a potentially huge impact on the private sector. For instance, some kinds of trading on Wall Street won't take place.
Bart Chilton, chairman of the U.S. Commodity Futures Trading Commission, said in a statement on Thursday the financial damage from a shutdown would be "potentially incalculable" – and the consequences of less regulatory policing "could be enormous." His own agency, he warned, was entering "dangerous territory" by making public its contingency plans.
States have worries of their own.
While the last shutdown in 1995 lasted only 20 days, Maryland had to come up with an extra $1.4 million in state employee salaries. Federal shares of those salaries had been suspended. The District of Columbia had to spend $4.4 million.
Over the last three decades, the government has shut down 16 times. This report by the Congressional Research Service covers some of the causes and consequences. A Goldman Sachs economist has estimated that a shutdown today would equal $8 billion in weekly spending.


text:
/*
 *          Author:Sam
 *          Email:ellen@hoyi.org
 *          CreateDate:2015-01-20
 *          ModifyDate:2015-01-20
 *          hoyi entities @ hoyi.org
 *          使用请在项目关于内标注hoyi版权,
 *          hoyi版权归hoyi.org所有
 */
using System;
using System.Collections.Generic;
using System.Configuration;
using System.Linq;
using System.Text;

namespace Infrastructure.Database.Cluster
{
    /// <summary>
    /// 数据库集群 操作.
    /// </summary>
    public class DataBaseCluster
    {
        /// <summary>
        /// 单集群.
        /// </summary>
        public static ClusterInfo cluster_a;
        /// <summary>
        /// 集群描述 配置文件内的内容
        /// </summary>
        public static string db_cluster_info_conf = "db_cluster_info";
        /// <summary>
        /// 初始化服务器列表.
        /// </summary>
        public static void InitServers()
        {
            if (cluster_a == null)
            {
                cluster_a = new ClusterInfo();

                IDatabase tmpdb;
                List<IDatabase> dbs = new List<IDatabase>();

                foreach (ConnectionStringSettings conns in ConfigurationManager.ConnectionStrings)
                {
                    tmpdb = DatabaseFactory.InitDatabase(conns);
                    if (tmpdb != null)
                        dbs.Add(tmpdb);
                }

                string db_cluster_info = ConfigurationManager.AppSettings[db_cluster_info_conf];
                string[] dbsp = db_cluster_info.Split('|');
                string mastername = dbsp[0];
                string re_masternames = dbsp[1];
                string slavernames = dbsp[2];
                string info_r_w_types = dbsp[3];

                IDatabase master = dbs.Single(s => s.DBServerName.Equals(mastername));

                List<IDatabase> re_master = dbs.Where(s=> re_masternames.Split(',').Contains(s.DBServerName)).ToList();
                List<IDatabase> slavers = dbs.Where(s => slavernames.Split(',').Contains(s.DBServerName)).ToList();

                Cluster_R_W_TYPE r_w_type = (Cluster_R_W_TYPE)Enum.Parse(typeof(Cluster_R_W_TYPE), info_r_w_types);

                cluster_a.Init(master, re_master, slavers, r_w_type);
            }
        }
        /// <summary>
        /// 获取写服务器.
        /// </summary>
        /// <returns></returns>
        public static IDatabase Get_WRITE_SERVER()
        {
            InitServers();
            // 如果客户端有切分区的标识,就到指定分区内拿数据.
            if (cluster_a != null)
            {
                return cluster_a.Get_WRITE_SERVER();
            }
            return null;
        }
        /// <summary>
        /// 获取读服务器.
        /// </summary>
        /// <returns></returns>
        public static IDatabase Get_READ_SERVER()
        {
            InitServers();
            if (cluster_a != null)
            {
                return cluster_a.Get_READ_SERVER();
            }
            return null;
        }
        /// <summary>
        /// 获取一个事务的新的读服务器.
        /// </summary>
        /// <returns></returns>
        public static IDatabase Get_Transaction_WRITE_SERVER()
        {
            InitServers();
            if (cluster_a != null)
            {
                return cluster_a.Get_NEW_WRITE_SERVER();
            }
            return null;
        }
    }
}


Ah, the age-old question prospective home buyers are haunted by: to rent or to buy? Buying (or not buying) a home is a big decision, and there is not an easy answer. While some believe buying a home is not a viable option, others believe renting a home is just a waste of money. For instance, a recent study completed by RENTCafe.com, determined that most millennials will pay $92,600 in total rent by the time they turn 30. That's a big chunk of cash that could have been put toward a down payment or mortgage payment, which creates equity in your home.
Your finances: Are you financially ready to buy a home? A home is not a liquid investment, and you can't count on being able to sell a home for a profit, or even break even, in your first few years of ownership. Plus, the down payment and mortgage are not the only costs associated with owning a home. Don't forget about the additional expense of utilities, insurance property taxes and potential Homeowner's Association fees—and that's before simple upkeep and repairs from routine wear and tear.
Your neighborhood: What is the financial state and housing market like in the area you're looking to live? Will a mortgage payment exceed rental costs in the area or vice versa? When you buy a home, you are also investing in the economy of the area in which you buy. Therefore, it's important to consider whether the neighborhood is stable or appreciating in value.
Your future plans: How long do you plan on staying? If you're confident you'll live in the area for at least 5 years, buying a home is something you should consider. If your future plans are up in the air, renting offers more flexibility to move around as needed and invest, save and/or spend elsewhere.
The real estate market: What is the current state of the real estate and mortgage market? Is it hot or not? Do your research and contact a professional for advice on the best times and places to purchase a home or rent a home.
Using Method Mortgage's Rent or Own Calculator is a quick-and-simple way to compare the true costs associated with renting or owning a home based on your length of stay and several other parameters. For more information or to discuss your specific situation, contact a Method Mortgage loan officer today!


The real estate sector has become more structured and accountable, post the implementation of various policy reforms, like RERA and GST, by the Modi government. Now developers just can't keep doing whatever they want. Instead, in this new regime, they need to streamline systems, processes and practices to make the whole process transparent to the end customer. The government's focus on affordable housing has also given a boost to the realty sector as this segment has become the fastest-growing segment in the realty market.
Regulatory reforms have also led to changes in developer strategies and customer buying patterns. We now see developers splitting their projects into smaller phases in order to reduce completion time, inventory overhang and manage cash flows. Additionally, end buyers are seeking security for their investments, and hence prefer to choose a developer with strong credentials and track record of delivery. Prospective home buyers' tax burden has also eased, following a 4% reduction in the goods & service tax (GST) to 8%. This has led to higher sales momentum, particularly in the affordable housing segment. The Credit Linked Subsidy Scheme (CLSS) has also helped the affordable housing a lot. It has basically been a big step for the construction sector by increasing activity on the demand side.
Not only residential, but the commercial space is also witnessing a systemic change with more focus on developing smart spaces that are more people centric. These developments are interactive, lively and cater to the millennials. Developers are trying to be innovative by creating new-age & modern developments that are a mix of retail, hospitality and next-gen work spaces while also continuing with the existing traditional commercial developments.
Now, the established developers are expected to expand their scope of business categories. The premium housing feature is an add-on to the affordable housing. Developers catering to the low-segment housing have expanded their focus on spacious and efficient projects for buyers with deep pockets, a trend that is expected to gain further momentum. However, the trend of affordable housing has remained intact and is likely to get further momentum.
India will be almost 50% urbanized by 2030. Smart cities with smarter ways of living along with affordable housing will help solve the problems of urban areas. Hence, our intention must be to create a positive environment to attain the Government of India's goal to achieve Housing for All by 2022.