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What They Do
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Quick Facts: Dental Hygienists
2020 Median Pay
Typical Entry-Level Education
Work Experience in a Related Occupation
Number of Jobs, 2020
Job Outlook, 2020-30
11% (Faster than average)
Employment Change, 2020-30
What Dental Hygienists Do
Dental hygienists examine patients for signs of oral diseases, such as gingivitis, and provide preventive care, including oral hygiene.
Nearly all dental hygienists work in dentists' offices, and many work part time.
How to Become a Dental Hygienist
Dental hygienists typically need an associate's degree in dental hygiene. Programs usually take 3 years to complete. All states require dental hygienists to be licensed; requirements vary by state.
The median annual wage for dental hygienists was $77,090 in May 2020.
Employment of dental hygienists is projected to grow 11 percent from 2020 to 2030, faster than the average for all occupations.
About 15,600 openings for dental hygienists are projected each year, on average, over the decade. Many of those openings are expected to result from the need to replace workers who transfer to different occupations or exit the labor force, such as to retire.
Explore resources for employment and wages by state and area for dental hygienists.
Compare the job duties, education, job growth, and pay of dental hygienists with similar occupations.
More Information, Including Links to O*NET
Learn more about dental hygienists by visiting additional resources, including O*NET, a source on key characteristics of workers and occupations.
What They Do ->
What Dental Hygienists Do About this section
Dental hygienists wear safety glasses, surgical masks, and gloves to protect themselves and their patients from diseases.
Dental hygienists examine patients for signs of oral diseases, such as gingivitis, and provide preventive care, including oral hygiene. They also educate patients about oral health.
Dental hygienists typically do the following:
Remove tartar, stains, and plaque from teeth
Apply sealants and fluorides to help protect teeth
Take and develop dental x rays
Assess patients' oral health and report findings to dentists
Document patient care and treatment plans
Educate patients about oral hygiene techniques, such as how to brush and floss correctly
Dental hygienists use many types of tools—including hand, power, and ultrasonic tools—in their work. In some cases, they use lasers. Hygienists remove stains with an air-polishing device, which sprays a combination of air, water, and baking soda. They polish teeth with a power tool that works like an automatic toothbrush. Hygienists also use x-ray machines to take pictures to check for tooth or jaw problems.
Dental hygienists talk to patients about ways to keep their teeth and gums healthy. For example, they may explain the relationship between diet and oral health. They may also advise patients on how to select toothbrushes and other oral care devices.
The tasks hygienists may perform, and the extent to which they must be supervised by a dentist, vary by state and by the setting in which the dental hygienist works. A few states allow hygienists with additional training, sometimes called dental therapists, to provide some restorative services, such as extracting primary teeth and placing temporary crowns.
<- Summary Work Environment ->
Work Environment About this section
Dental hygienists discuss diet and other topics that affect a patient's dental health.
Dental hygienists held about 206,100 jobs in 2020. The largest employers of dental hygienists were as follows:
Offices of dentists 94%
Offices of physicians 1
Dental hygienists wear safety glasses, surgical masks, and gloves to protect themselves and patients from infectious diseases. When taking x rays, they follow procedures to protect themselves and patients from radiation.
Many dental hygienists work part time. Dentists may hire hygienists to work only a few days a week, so some hygienists work for more than one dentist.
<- What They Do How to Become One ->
How to Become a Dental Hygienist About this section
Dental hygienists remove tartar and plaque from teeth.
Dental hygienists typically need an associate's degree in dental hygiene; they may also get a bachelor's degree. Master's degree programs in dental hygiene are available but are relatively uncommon. A bachelor's or master's degree usually is required for research, teaching, or clinical practice in public or school health programs.
Dental hygiene programs are often found in community colleges, technical schools, and universities. The Commission on Dental Accreditation, part of the American Dental Association, accredits more than 300 dental hygiene programs.
Programs typically take 3 years to complete and offer laboratory, clinical, and classroom instruction. Areas of study include anatomy, medical ethics, and periodontics, which is the study of gum disease.
High school students interested in becoming dental hygienists should take courses in biology, chemistry, and math. Most dental hygiene programs also require applicants to complete prerequisites, which often include college-level courses. Specific requirements vary by school.
Important Qualities
Critical thinking. Dental hygienists must be able to assess and evaluate patients and to develop oral hygiene care plans.
Communication skills. Dental hygienists must share information with dentists and patients about oral health status, oral hygiene care plans, and, if necessary, lifestyle counseling.
Detail oriented. Dental hygienists must follow specific rules and protocols to help dentists diagnose and treat a patient. Depending on the state in which they work and/or the treatment provided, dental hygienists may work without the direct supervision of a dentist.
Dexterity. Dental hygienists must be good at working with their hands. They generally work in tight spaces on a small part of the body, which requires fine motor skills using precise tools and instruments.
Interpersonal skills. Dental hygienists work closely with dentists. They also must be considerate in working with patients, especially with those who are sensitive to pain or who have fears about undergoing dental treatment.
Problem-solving skills. Dental hygienists develop and implement oral hygiene care plans to maintain or improve patients' oral health.
Licenses, Certifications, and Registrations
Every state requires dental hygienists to be licensed; requirements vary by state. In most states, a degree from an accredited dental hygiene program and passing written and clinical examinations are required for licensure. To maintain licensure, hygienists must complete continuing education requirements. For specific requirements, contact your state's Board of Dental Examiners.
Many jobs also require cardiopulmonary resuscitation (CPR) certification.
<- Work Environment Pay ->
Pay About this section
Median annual wages, May 2020
Healthcare diagnosing or treating practitioners
Total, all occupations
Note: All Occupations includes all occupations in the U.S. Economy.
Source: U.S. Bureau of Labor Statistics, Occupational Employment and Wage Statistics
The median annual wage for dental hygienists was $77,090 in May 2020. The median wage is the wage at which half the workers in an occupation earned more than that amount and half earned less. The lowest 10 percent earned less than $54,200, and the highest 10 percent earned more than $104,420.
In May 2020, the median annual wages for dental hygienists in the top industries in which they worked were as follows:
Offices of dentists $77,330
Offices of physicians 75,590
Benefits, such as vacation, sick leave, and retirement contributions, vary by employer and may be available only to full-time workers.
<- How to Become One Job Outlook ->
Job Outlook About this section
Percent change in employment, projected 2020-30
Source: U.S. Bureau of Labor Statistics, Employment Projections program
Some of the projected employment growth in this occupation is due to recovery from the COVID-19 recession that began in 2020.
Demand for dental services will increase as the large baby-boom population ages and as people keep more of their original teeth than in previous generations.
Studies linking oral health and general health, along with efforts to expand access to oral hygiene services, will continue to drive demand for preventive dental services, including those performed by hygienists. In addition, demand for dental hygienists is expected to grow as state laws increasingly allow dental hygienists to work at the top of their training.
Employment projections data for dental hygienists, 2020-30
Occupational Title
SOC Code
Employment, 2020
Projected Employment, 2030
Change, 2020-30
29-1292 206,100 229,200 11 23,100 Get data
<- Pay State & Area Data ->
State & Area Data About this section
Occupational Employment and Wage Statistics (OEWS)
The Occupational Employment and Wage Statistics (OEWS) program produces employment and wage estimates annually for over 800 occupations. These estimates are available for the nation as a whole, for individual states, and for metropolitan and nonmetropolitan areas. The link(s) below go to OEWS data maps for employment and wages by state and area.
Projections Central
Occupational employment projections are developed for all states by Labor Market Information (LMI) or individual state Employment Projections offices. All state projections data are available at www.projectionscentral.com. Information on this site allows projected employment growth for an occupation to be compared among states or to be compared within one state. In addition, states may produce projections for areas; there are links to each state's websites where these data may be retrieved.
CareerOneStop includes hundreds of occupational profiles with data available by state and metro area. There are links in the left-hand side menu to compare occupational employment by state and occupational wages by local area or metro area. There is also a salary info tool to search for wages by zip code.
<- Job Outlook Similar Occupations ->
Similar Occupations About this section
This table shows a list of occupations with job duties that are similar to those of dental hygienists.
ENTRY-LEVEL EDUCATION
Dental Assistants
Dental assistants provide patient care, take x rays, keep records, and schedule appointments.
Postsecondary nondegree award $41,180
Dentists diagnose and treat problems with patients' teeth, gums, and related parts of the mouth.
Doctoral or professional degree $164,010
Medical Assistants
Medical assistants complete administrative and clinical tasks in hospitals, offices of physicians, and other healthcare facilities.
Physician assistants practice medicine on teams with physicians, surgeons, and other healthcare workers.
Master's degree $115,390
Physicians and Surgeons
Physicians and surgeons diagnose and treat injuries or illnesses and address health maintenance.
Doctoral or professional degree This wage is equal to or greater than $208,000 per year.
Radiation Therapists
Radiation therapists treat cancer and other diseases in patients by administering radiation treatments.
Associate's degree $86,850
Radiologic and MRI Technologists
Radiologic technologists perform diagnostic imaging examinations on patients. MRI technologists operate magnetic resonance imaging (MRI) scanners to create diagnostic images.
Registered nurses (RNs) provide and coordinate patient care and educate patients and the public about various health conditions.
Bachelor's degree $75,330
<- State & Area Data More Info ->
Contacts for More Information About this section
For information about educational requirements and available accredited programs for dental hygienists, visit
American Dental Hygienists' Association
For information about accredited programs and educational requirements, visit
Commission on Dental Accreditation, American Dental Association
The State Board of Dental Examiners in each state can provide information on licensing requirements.
For a career video on dental hygienists, visit
O*NET
<- Similar Occupations
Bureau of Labor Statistics, U.S. Department of Labor, Occupational Outlook Handbook , Dental Hygienists,
at https://www.bls.gov/ooh/healthcare/dental-hygienists.htm (visited January 18, 2022).
Last Modified Date: Wednesday, September 8, 2021
The What They Do tab describes the typical duties and responsibilities of workers in the occupation, including what tools and equipment they use and how closely they are supervised. This tab also covers different types of occupational specialties.
The Work Environment tab includes the number of jobs held in the occupation and describes the workplace, the level of physical activity expected, and typical hours worked. It may also discuss the major industries that employed the occupation. This tab may also describe opportunities for part-time work, the amount and type of travel required, any safety equipment that is used, and the risk of injury that workers may face.
The How to Become One tab describes how to prepare for a job in the occupation. This tab can include information on education, training, work experience, licensing and certification, and important qualities that are required or helpful for entering or working in the occupation.
The Pay tab describes typical earnings and how workers in the occupation are compensated—annual salaries, hourly wages, commissions, tips, or bonuses. Within every occupation, earnings vary by experience, responsibility, performance, tenure, and geographic area. For most profiles, this tab has a table with wages in the major industries employing the occupation. It does not include pay for self-employed workers, agriculture workers, or workers in private households because these data are not collected by the Occupational Employment and Wage Statistics (OEWS) survey, the source of BLS wage data in the OOH.
The State and Area Data tab provides links to state and area occupational data from the Occupational Employment and Wage Statistics (OEWS) program, state projections data from Projections Central, and occupational information from the Department of Labor's CareerOneStop.
The Job Outlook tab describes the factors that affect employment growth or decline in the occupation, and in some instances, describes the relationship between the number of job seekers and the number of job openings.
The Similar Occupations tab describes occupations that share similar duties, skills, interests, education, or training with the occupation covered in the profile.
Contacts for More Information
The More Information tab provides the Internet addresses of associations, government agencies, unions, and other organizations that can provide additional information on the occupation. This tab also includes links to relevant occupational information from the Occupational Information Network (O*NET).
The wage at which half of the workers in the occupation earned more than that amount and half earned less. Median wage data are from the BLS Occupational Employment and Wage Statistics survey. In May 2020, the median annual wage for all workers was $41,950.
Additional training needed (postemployment) to attain competency in the skills needed in this occupation.
Typical level of education that most workers need to enter this occupation.
Work experience that is commonly considered necessary by employers, or is a commonly accepted substitute for more formal types of training or education.
The employment, or size, of this occupation in 2020, which is the base year of the 2020-30 employment projections.
The projected percent change in employment from 2020 to 2030. The average growth rate for all occupations is 8 percent.
The projected numeric change in employment from 2020 to 2030.
Employment Change, projected 2020-30
Growth Rate (Projected)
The percent change of employment for each occupation from 2020 to 2030.
Projected Number of New Jobs
Projected Growth Rate
The projected percent change in employment from 2020 to 2030.
U.S. Bureau of Labor Statistics Office of Occupational Statistics and Employment Projections PSB Suite 2135 2 Massachusetts Avenue NE Washington, DC 20212-0001
Telephone: 1-202-691-5700 www.bls.gov/ooh Contact OOH


Our company is in the possession of a capacious and spacious warehouse unit that is fully equipped with all the required amenities needed for proper and secured storage. The warehouse is fabricated into various segments, which enables us to store the range of products as per their nature and specifications, thus making their identification and retrieval process hazel free and helps in swift delivery of the final stocks.
We also pay substantial attention in packaging of these products, ensuring their safe transit and delivery within the stipulated span of time. We ensure that these are packed in high grade quality packaging material, which adheres to industry set parameters, to safeguard the range of products from any damage or mishandling.
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Owing to their pain staking efforts, we are able to successfully offer our clients, an unmatched qualitative range, by incorporating the latest designs and thus attaining a top status in the industry. Over the decade, we have reached the high altitudes of success due to their unbound commitment in analyzing our customer's requirements and demands assisting us to keep abreast of time. In this aspect, their strategic market study has enabled us in satisfying our broad customer base spread all across the nation.
We offer a quality tested and genuine range of hardware collection. Our team of quality experts ensures that each and every product offered by us is manufactured from superior quality raw material to as per the industry quality standards. Furthermore, our infrastructure is segregated into several specialized departments like manufacturing unit, sales & marketing and quality testing that help us in timely delivery of provided products.


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Освобождение линии — тактический приём, при котором линия освобождается от фигур, мешающих нанести решающий удар.
В шахматной композиции тактический элемент комбинации — освобождение линии от фигур, препятствующих проведению манёвра другой фигурой.
 Простое освобождение линии, в задаче: фигуры белых освобождают линию, а фигуры чёрных отвлекаются от неё, затем белые наносят решающий удар по этой линии.
 Тематическое освобождение линии: фигура совершает манёвр вдоль линии, освобождая её для другой фигуры. См., например, бристольская тема, темы Лойда, Тертона, Цеплера—Тертона, Бруннера — Тертона и другие.

Литература

Шахматная тактика
Шахматная композиция
Темы в шахматной композиции

redpajama_set_name: RedPajamaWikipedia


This morning, Colorado Governor Jared Polis signed an executive order that will allow Colorado to take a big step toward the electric vehicle future that we need to tackle our state's current air pollution problem. The Governor's order takes meaningful steps toward an electric vehicle future including moving forward on a statewide electric vehicle program, dedicating millions more dollars toward converting dirty diesel buses to electric-powered, and building out electric vehicle charging stations in a systematic way across the state.
Good news came out of Denver City Council last night after they unanimously passed new safety and operational rules for electric scooters to allow their use in bike lanes and on city streets that have speed limits under 30 mph.
Today, Colorado's Air Quality Control Commission (AQCC) voted to adopt the Low Emission Vehicle (LEV) Program standards for cars and trucks. Vehicle emissions are among the largest contributors to carbon pollution in Colorado and contribute to the smog and air toxins that threaten public health. The new LEV standards will reduce the greenhouse gas emissions from cars that threaten our health and economy, help Coloradans breathe easier, and help families save money at the pump.
On Tuesday, CoPIRG Foundation organized an event with clean car advocates to announce that over 7,600 Coloradans have called on Colorado's Air Quality Control Commission (AQCC) to adopt state emission standards for gas-powered vehicles. The AQCC will be voting on whether to adopt the standards on either Thursday, November 15th or Friday, November 16th, depending on when the hearing on the rule concludes.


What is a sitemap? And how can you use one to help improve your rankings? If you want answers to these questions then check out this guide to SEO and sitemaps.
Converting website visitors into actual customers is a lot harder than most business owners realize. Only around 22 percent of business owners claim to be content with their current conversion rates.
The key to increasing website traffic is optimizing every aspect of your website for search engine success. While most business owners know about the importance of developing a keyword and content strategy, many fail to realize how important their sitemap when it comes to getting search engine attention.
An adequate SEO sitemap strategy can make attracting new customers much easier. In essence, a sitemap provides search engines with a blueprint of your website. The metadata found in your sitemap also informs search engines about how often pages are being updated and how these pages relate to one another.
Are you trying to optimize your sitemap? If so, consider the helpful tips below.
One of the main mistakes most business owners make when it comes to their sitemap is attempting to update it manually. Often times, this will lead to this task being ignored and a website's search engine ranking suffering as a result.
Instead of adding one more task to your already overflowing plate, you need to find tools to help you with this task. Luckily, there are a variety of tools that can automatically update sitemaps on a regular basis.
If you are using a WordPress website, you can use the built-in Yoast SEO program to handle this important job. Before downloading a plugin or software program, you need to make sure it is compatible with your website.
If you are new to the world of sitemap optimization, you may not realize that you can submit this important file directly to Google. Adding a test sitemap on the Google Search Console can be very beneficial.
Once you have uploaded the sitemap, you can test it to see if there are any errors present. If Google gives you error messages, your main goal needs to be fixing these problems immediately.
By submitting this sitemap, you can also begin the process of having the pages on your website indexed by this search engine. Doing this will allow you to get on Google's radar and begin your ascent up the search engine results ladder.
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Properly prioritizing the hierarchy of your sitemap is no easy task. If you are apprehensive about trying this on your own, you may want to reach out to SEO professionals for assistance.
When trying to have success with sitemap SEO, be sure to pay close attention to issues with indexing. If you notice that all of the pages on your website have not been indexed, it may be due to errors on these pages.
If you are running a large e-commerce website, finding these indexing issues can be challenging. Most experts recommend splitting these pages into different sitemaps. By testing each individual sitemap, you can pinpoint where your problems are.
Once you have located the problem pages on your website, you will need to make a decision on whether to fix them or label them as noindex. By labeling these pages noindex, you can avoid these problems in the future.
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One of the best ways to solve this issue is by creating canonical versions of your various site URLs. Doing this will make crawling much easier for search engine bots. The easier you can make the crawling process, the higher your site will ultimately be ranked.
Are you running a large website and are having trouble keeping up with all of your meta robots? Rather than continually dealing with this issue, you need to think about creating a dynamic XML sitemap.
These particular sitemaps will determine when a page needs to be changed from index to noindex. While you can create a dynamic XML sitemap manually, it can be extremely challenging.
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« MCMXXXVMCMXXXVII »
Roman Numerals: MCMXXXVI = 1936
MMXXIII-I-XXXI XXII:VII:XXXII
The year 1936 began on a Wednesday and was a leap year. Here you can read more about what happened in the year 1936.
The number 1936
The number 1936 is divisble by 2, 4, 8, 11, 16, 22, 44, 88, 121, 176, 242, 484 and 968 and can be prime factorized into 24×112.
1936 as a binary number: 11110010000
1936 as an octal number: 3620
1936 as a hexadecimal number: 790
Numbers close to MCMXXXVI
Below are the numbers MCMXXXIII through MCMXXXIX, which are close to MCMXXXVI. The right column shows how each roman numeral adds up to the total.
1933 = MCMXXXIII = 1000 + 1000 − 100 + 10 + 10 + 10 + 1 + 1 + 1
1934 = MCMXXXIV = 1000 + 1000 − 100 + 10 + 10 + 10 + 5 − 1
1935 = MCMXXXV = 1000 + 1000 − 100 + 10 + 10 + 10 + 5
1936 = MCMXXXVI = 1000 + 1000 − 100 + 10 + 10 + 10 + 5 + 1
1937 = MCMXXXVII = 1000 + 1000 − 100 + 10 + 10 + 10 + 5 + 1 + 1
1938 = MCMXXXVIII = 1000 + 1000 − 100 + 10 + 10 + 10 + 5 + 1 + 1 + 1
1939 = MCMXXXIX = 1000 + 1000 − 100 + 10 + 10 + 10 + 10 − 1

redpajama_set_name: RedPajamaCommonCrawl


Albert Einstein is arguably considered one of the smartest people to have ever lived, so when quotes are attributed to him, most of us would be wise to listen what he might have said. Below are 3 such quotes.
Compound Intertest is the Most Power Force in the Universe.
Compound Intertest is the 8th Wonder of the World.


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Advisory/Request Assistance – Suspicious Male
AdvisoryPublic Safety Alert
The Regina Police Service is asking the public for information in relation to a complaint of a suspicious male and advising the public to be on the lookout for this individual. Police are investigating this complaint as a possible attempted abduction.
The preliminary information available indicates that at about 1:50 p.m. today, Friday, July 18, 2014, a ten year-old female child was walking from one building to another (Conservatory Building to Darke Hall) on the University of Regina College Avenue campus. The girl was part of a group but was walking some distance behind the rest of the group as they entered the other building. An unknown male called out to the child and, when she came nearer, he grabbed her by the arm. She broke free and ran to tell authorities, including Campus Security, who contacted police. The girl was not physically harmed and her parent was notified. While police were obtaining more information, Wascana Centre Police and U-of-R Security did an area search but did not locate the suspect. The suspect's motive is not known at this time.
The suspect is described as male, Caucasian, approximately 50-65 years old, about 5' 9" tall, with a medium build. The victim described the suspect as having a scruffy, patchy beard and collar-length, combed-back, greyish-black hair. He was wearing jogging clothes and runners.
Anyone who has information about this event, or has information that could help police identify and locate this suspect is asked to contact the Regina Police Service at 777-6500 or call Crime Stoppers at 1-800-222-8477.
Categories: Advisory, Public Safety Alert July 18, 2014
PreviousPrevious post:Saskatoon Police Service Request InformationNextNext post:Police Investigating Fourth Homicide
Public Disclosure / Public Safety Alert: Louis Ted MERCREDI
Public Advisory – Police Operation 4700 Block Pasqua Street


Turmeric paste has a variety of uses due to its healing properties. It has been known to relieve ailments such as inflammation, sore joints, arthritis, and also works as a liver cleanser, antioxidant, digestive system enhancer, and astringent. Turmeric paste helps to alleviate pain and purify the blood too! Additionally, studies have shown that turmeric can help prevent and/or ease heart disease, certain cancers and Alzheimer's disease.
Combine turmeric and water in a medium saucepan over medium-high heat. Stir or whisk.
Bring the mixture to a boil. Continue to stir until a thick paste is formed.
Allow the turmeric paste to cool.
Stir one teaspoon of paste into ghee.
Mix 1 part turmeric to 2 parts honey. Follow this sweeter paste with warm water.


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Jean Paul Farrugia (born 21 March 1992) is a Maltese professional footballer who currently plays for Sliema Wanderers.

International career
Farrugia played his first international game with the senior national team on 4 June 2014 in and against Gibraltar (1–0), after he came on as a substitute for André Schembri in the 74th minute of that game. He scored his first goal on March 26, 2017 against Slovakia.

International goals
Scores and results list Malta's goal tally first.

Honours
Hibernians
Maltese League (2): 2008–09, 2014–15
Maltese FA Trophy (1): 2012–13
Sliema Wanderers
Maltese FA Trophy (1): 2015–16

References

External links

1992 births
Living people
People from Pietà, Malta
Maltese footballers
Malta international footballers
Association football forwards
Hibernians F.C. players
Marsaxlokk F.C. players
FC Chiasso players
FC Spartak Trnava players
Slovak Super Liga players
Maltese Premier League players
Swiss Challenge League players
Expatriate footballers in Switzerland
Expatriate footballers in Slovakia
Maltese expatriate sportspeople in Slovakia
Maltese expatriate sportspeople in Switzerland


The Floured Apron provides women from underserved communities with an opportunity to forge a more secure career path within the culinary industry. Through hands-on training in food safety and sanitation, knife and food prep skills, and bread and pastry baking, these women gain the knowledge they need to set out on new, promising career paths.
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The tournament slogan is "No friendlies. Just football." And the Italian clubs certainly lived up to it. Valencia beat Everton 1-0 in the late game for fifth place.
Tuesday's matches served as hors d'oeuvres for Wednesday's main course — the 9 p.m. championship game between Real Madrid and Chelsea, preceded by the third-place match between A.C. Milan and the Los Angeles Galaxy, the only non-European team in the event. A sellout crowd of 70,000 is expected.
For the European clubs, this tournament is a chance to give players game conditions three weeks before the start of their season. It also allows them to connect with fans and build their brand in the United States. For the Galaxy, which features U.S. national team star Landon Donovan and Ireland captain Robbie Keane, it's a chance to test themselves against some of the biggest names in the sport.
Inter and Juventus entered Tuesday's match with something to prove after disappointments in the earlier rounds. Juventus, the reigning Serie A champion, lost in penalty kicks to Everton and lost 3-1 to the Galaxy. Inter, also known as the Nerazzurri, fared worse, going scoreless with a 2-0 loss to Chelsea and a 4-0 loss to Valencia.
That is why Tuesday's victory felt so sweet for Inter players.
Juventus tied it in the 45th minute on a penalty kick by Chilean midfielder Arturo Vidal. Juventus was awarded the kick after Mirko Vucinic backed into the box against Inter defender Juan Jesus and fell. Jesus received a yellow card and Vidal got the equalizer just past the outstretched arms of Inter keeper Handanovic, who guessed right but couldn't reach.
Juventus coach Antonio Conte said the team leaves with plenty of positives, despite the eighth-place finish.


Sponge Daubers are made of high-density foam and are the ideal compact and hugely versatile crafting tool. Some of the many uses include applying paints stains, perfect placement of dyes, inks, applying liquid adhesives and more. Also, sponge daubers are perfect tools for stamping, stenciling and blending. Great for use on many surfaces such as paper, fabric, metal, plastic and much more. Use with water or solvent based inks and mediums. Place the Sponge Dauber on your fingertip for ultimate control. Easily cleaned with All-Purpose Stamp Cleaner.


We live in a world that has been dominated by a masculine approach. My profession has been, predominantly, lead by men and women who have embodied this approach, including myself. Medicine and many other professions are focused on structure, timelines, productivity, determination, discipline and physical stamina. Women have been incredibly successful in many realms where they have learned, through years of hard work, to walk, talk and think like a man. And it's been an essential part of how we have been elevated to our current place in the professional world. We need women to step up and embrace the logic and task-oriented approach that has gained us a seat at the table. I am grateful to those women (and those qualities in all of us) for how far we have come.
Centuries of living in a world created by men, for men, have taught us not to trust our feminine instincts. Yet, many women sense that something is missing. Restlessness and overwhelm have become the norm. Intuition whispers that there is better way. Inner yearnings are waking us up to possibilities that were, until now, impossible.
As a generation, we are the first women to taunt the realization of our fullest potential. It is within our capacity to heal our lives, shape our children and save our world. Our grandmothers struggled to open doors for us and our daughters are counting on us to walk through those doors, break down the walls and shatter the glass ceiling.
A different world is emerging.
A world that the Dalai Lama clearly states will be saved by the Western woman (Vancouver Peace Summit, 2009).
Women who embrace their authenticity.
Women who express their uniqueness.
Women who allow themselves to be seen.
Women who take a stand for other women and create space for ALL to shine.
We don our stilettos (or penny loafers), carry our bling-encrusted hand-bag (or backpack) and take a small step for womankind into a male-dominated world and speak our truth. We bring to the table compassion, caring, sensitivity and even tears. We bless our families and offices with flexibility, empathy, creativity and intuitive genius.
We believe, despite what society has been telling us, that we have what it takes to not only succeed but to lead.
We will not achieve the changes we desire by aligning with old stories or false beliefs. The only way to have the life we yearn for it to trust in our capacity to become everything and anything we want to and then take a giant leap to make it real.
Before we "blame" external conditions for fear, depression, anxiety, insomnia or stress, it's time to look inside. You are your own best advocate and you need to be your own best friend.
If you are waiting for some (any) external situation to arrive before you prioritize yourself, the wait is over!
Your life has arrived; don't let it pass you by.
Time will not magically appear, believe me, I've tried. Abra-ca-da-bra!
"Money does not grow on trees", says every father everywhere.
Deep and lasting marriages don't blossom out of neglect and apathy and we should be glad they don't because fire and passion are so much more fun!
My gift to you is this journaling exercise. Sit quietly and reflect on these 3 questions.
You will create deeper self-compassion if you answer with empathy and honesty. Your responses will uncover the path to making a positive change in your life that will feel centered and aligned with your true nature. You may realize something about yourself you didn't know. My hope is that you learn to listen inward when external noise is deafening, giving you a place to turn for answers that are always true to you.
Consider what it would be like to be fully YOU. What if you could take the filters off and stop trying so hard to please others? How would life look if you brought your best to every situation, no exceptions? If you structured life so that you had space for yourself and time to truly feel your creative impulses.
Consider what it would mean for others if you owned your power. How would your husband respond if you greeted him, each day, with love, acceptance, non-judgment and committed partnership. Consider the wife you become when you feel so good about yourself and your contribution that you exude happiness in every interaction. What would your home be like if you had time to hear your children's stories, sing their songs, dance their crazy moves and cuddle them each night?
Consider a world inhabited by strong women, like you, stepping into leadership and supporting each other to do the same. Women who understand their own needs, prioritize their own self-care and bring a fully functioning, highly capable, healthy, vital and joyful woman into every life and business interaction?
Imagine what it would mean for you and for the generations that follow if you decide, today, to own your life, extend your gifts, share your knowledge and act on the inner yearnings that are bubbling inside you.
Let's share your answers in our Empowered Women's Circle. Join our growing wellness movement for like-minded, health-conscious women. Everyone is welcome.
Sign up for the Empowered Women's Circle HERE!


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PIB 21st January
Home » PIB 21st January
PIB summaries Jan 2020
Pragati Scheme
Defense Acquisition Council
Center of Excellence for Studies in Classical Telugu (CESCT), Nellore
Central Government Notifies National Startup Advisory Council
Proactive governance and timely implementation
The platform is aimed at addressing common man's grievances, and simultaneously monitoring and reviewing important programmes and projects of the Government of India as well as projects flagged by State Governments
The PRAGATI platform uniquely bundles three latest technologies: Digital data management, video-conferencing and geo-spatial technology.
It also offers a unique combination in the direction of cooperative federalism since it brings on one stage the Secretaries of Government of India and the Chief Secretaries of the States.
With this, the Prime Minister is able to discuss the issues with the concerned Central and State officials with full information and latest visuals of the ground level situation. It is also an innovative project in e-governance and good governance.
It is a three-tier system (PMO, Union Government Secretaries, and Chief Secretaries of the States).
Issues to be flagged before the PM are picked up from the available database regarding Public Grievances, on-going Programmes and pending Projects
DEFENCE ACQUISITION COUNCIL
The Defence Acquisition Council is the highest decision-making body in the Defence Ministry for deciding on new policies and capital acquisitions for the three services (Army, Navy and Air Force) and the Indian Coast Guard.
The Minister of Defence is the Chairman of the Council.
It was formed, after the Group of Ministers recommendations on 'Reforming the National Security System', in 2001, post Kargil War (1999).
Set up under the Central Institute of Indian Languages (CIIL), Mysuru after Telugu was recognized as a Classical Language, in 2008.
The Center focusses on the protection, promotion and propagation of Classical Telugu
For more details on classical Telugu Literature and poets: Click here
Why in news?
The Central Government has notified the structure of the National Startup Advisory Council to advise the Government on measures needed to build a strong ecosystem for nurturing innovation and startups in the country to drive sustainable economic growth and generate large scale employment opportunities
Council will suggest measures to foster a culture of innovation amongst citizens and students in particular
Promote innovation in all sectors of economy across the country, including semi-urban and rural areas
Support creative and innovative ideas through incubation and research and development to transform them into valuable products
The National Startup Advisory Council will be chaired by Minster for Commerce & Industry.
The Council will consist of the non-official members, to be nominated by Central Government
Department for Promotion of Industry and Internal Trade will be the Convener of the Council
Since it started operations in 1996, UNAIDS provides the strategic direction, advocacy, coordination and technical support needed to catalyse and connect leadership from governments, the private sector and communities to deliver life-saving HIV services
UNAIDS is leading the global effort to end AIDS as a public health threat by 2030 as part of the Sustainable Development Goals.
UNAIDS is a model for United Nations reform and is the only cosponsored Joint Programme in the United Nations system. It draws on the experience and expertise of 11 United Nations system Cosponsors and is the only United Nations entity with civil society represented on its governing body
The UNAIDS Secretariat has offices in 70 countries, with 70% of its staff based in the field, and has a budget of US$ 140 million for 2018. The budget for the Joint Programme for 2018 is US$ 242 million


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Blackadder outlines how much Bath Rugby want to keep Anthony Watson beyond this season
The England and Lions back's contract is due to expire next summer
Daniel EvansHead of digital sport
Updated 18:24, 3 SEP 2018
When a 24-year-old who plays for England and the Lions has a contract up at the end of the season, there will inevitably be big interest in his signature.
But the speculation about Anthony Watson's future has started very early. According to French broadcaster RMC Sport, four unnamed Top14 clubs are showing an interest in prising him away from the Rec next summer.
Whether that's true or not it's not unlikely, but any suitors would have to be persuasive because he's right at the top of the list of players Bath Rugby want to keep for the very long term.
"We want Anthony to be here for the rest of his career," director of rugby Todd Blackadder told Somerset Live.
"Anthony shows great leadership and is one of our best players. We've got to make sure we do our due diligence, but we certainly want him to stick around, there's no doubt about that."
Bath Rugby analysis - They were very poor at Bristol Bears but it's not the end of the world
Watson is one of at least 20 players in the first-team squad in the final year of his contract. Any move abroad would mean that, after the 2019 World Cup in Japan, under the current selection policy, he would not be able to play for England.
As previously reported, Watson ruptured his left Achilles' tendon while playing for England against Ireland at Twickenham in March.
Anthony Watson leaves the pitch after rupturing an Achilles' tendon playing for England against Ireland at Twickenham (Image: Clive Rose/Getty Images)
The initial prognosis was for a six-month recovery, however he needed another operation on the same injury in July.
BBC Sport reported last week that he re-ruptured the tendon while catching an American football during and NFL photoshoot.
Somerset Live understands scans showed the tendon had not healed properly in the first place, however, and a second operation was inevitable regardless of whether he hurt himself that day.
Modest Jackson Willison shrugs off the skill which makes him a midfield danger
Watson is highly unlikely to play for Bath before a decision is made by him and/or the club about whether he signs a new deal. He might be tempted by a new challenge, of course, but Bath certainly want him to stay.
"There are a lot of players we want to keep," said Blackadder. "A player's value to the club is how well they play for this club.
"It's really, really simple. We want to retain all the players that actually play fantastic rugby for Bath. They've always got a future here.
Anthony Watson poses in Bath Rugby's away kit for the 2018/19 season (Image: Dan Mullan/Getty Images)
"There are always going to be clubs trying to poach and entice players. What we hope is to have such a good set-up and culture at this club that no-one ever wants to leave.
"That's our goal. It's our job to provide an environment where we can meet all their needs, as well as the financial ones.
Poll Result: Bath Rugby fans have high expectations for the 2018/19 Gallagher Premiership
"When it comes to the financials we've got some big decisions to make. Depending how much clubs are prepared to pay we can't afford to keep everyone.
"We've just got to make sure that we're doing the little things really well."


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Q: Error MSB3482: An error occurred while signing: Failed to sign I have .pfx certificate which is self signed. I've signed the ClickOnce manifest of my VSTO (Excel Add-In project type in Visual Studio) project. Recently we have migrated the application from .Net 3.5 to 4.5 and Office 2007 to 2010 since then project (that used to work) and now it gives me an error:

An error occurred while signing: Unknown error "-2147012894"
  SignTool Error: An unexpected internal error has occurred
  The certificate is perfectly valid and not expired

Anyone had this kind of error before? Any suggestions?

A: Try creating a new certificate.
Look at the "Signing" section under the project's properties.
In my case, my MSB3482 error occurred because my certificate had indeed expired.  I clicked the button called "Create Test Certificate" and I was able to build and run again. (At least for another year)

A: Go to Project properties > Signing > Uncheck "Sign the ClickOnce manifests" to run your code

redpajama_set_name: RedPajamaStackExchange


When the Microsoft Lumia 950, Lumia 950 XL, and Lumia 550 ship in November, they'll be some of the first smartphones available with Windows 10 software pre-installed.
But Microsoft will also begin rolling out Windows 10 as an update for some existing phones in December.
It's worth pointing out that while all of these phones will get user interface updates and support for Universal Windows Apps, among other things, they will not be able to support the new Continuum for Phones feature that lets you use a Windows 10 phone as a desktop by plugging in a docking station, keyboard, mouse, and monitor.
That's because these phones just don't have the horsepower (or USB Type-C ports) available from the Lumia 950 and Lumia 950 XL.
It's also worth noting that while Microsoft uses the Windows 10 name to describe both its smartphone and desktop PC software, the smartphone version is actually Windows 10 Mobile. It shares a lot of code with the desktop version of Windows 10, but you won't be able to run legacy Windows apps. On the other hand, you will be able to run new Universal Windows apps including the latest version of Microsoft Office.
Have a supported phone and don't want to wait until December? You can join the Windows Insider program to take preview builds of Window 10 Mobile for a spin… but only if you feel comfortable running beta software on your phone.
I know what I am not buying for Christmas this year. Thx Microsoft!
I'll have a new iPhone 6s before December.


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Mixed-phase clouds slow down global warming, but only up to a certain point
by University of Oslo
As the ice in the clouds melts into droplets, they reflect more sunlight. But in the end there is no more ice left to melt.
Clouds that contain both water droplets and ice crystals, calledmixed-phase clouds, have a slowing effect on global warming. This is because the clouds reflect more and more sunlight as ice turns to water.
But what happens when all the ice crystals have turned into droplets?
Doctoral Research Fellow Jenny Bjordal and Professor Trude Storelvmo at the Department of Geosciences at the University of Oslo have tried to figure it out.
"What we have found, is exciting, but also scary," Storelvmo says to Titan.uio.no.
The results were published today in the scientific journal Nature Geoscience.
Clouds of ice and water
The clouds they have studied are in areas of the atmosphere with temperatures between 0 and 38 degrees below zero.
"The area where we find most of them is across the Southern Ocean. They are also found elsewhere, but that is where most of them are," Bjordal says.
As climate scientists, they do not look at individual clouds and how they change or move. They study how the clouds change in an area over a long period of time—and whether they move in height, for example.
"These clouds consist of a mixture of ice crystals and drops," Storelvmo says.
"When the climate gets warmer, more of the ice crystals will melt," Bjordal explains.
Each small ice crystal turns into many even smaller droplets which gives an overall larger surface.
"Then the clouds reflect more sunlight," Bjordal says.
"In that sense, those clouds have helped us a little. They have curbed the warming so far," Storelvmo says.
Feedback effect
What happens to these clouds is an example of what is calledfeedback effects. Higher temperatures on Earth lead to changes in the clouds, which in turn affect the temperature.
Feedback effects can be both positive and negative. What the researchers call a positive feedback, means that the temperature will be even higher. Negative for the climate, that is, but positive in the calculations.
Mixed-phase clouds have a negative feedback. When it gets warmer, they reflect more light. They prevent sunlight from hitting the earth. Positive for the climate, but a minus in the figures.
"This means that we get a smaller temperature rise than we would have had without this effect," Bjordal says.
The hotter it gets, the more ice will melt. This effect will increase as the temperature rise and keep it in check a bit. It does not stop it, but slows it down.
But only up to a certain point.
What happens when all the ice is melted?
At some point, there will be no more ice left. The clouds will still reflect sunlight, but the effect will not be able to increase and become even greater.
"As long as you have ice that can melt, the clouds will constantly reflect more and more. But eventually it will reach a constant level, while the temperature continues to rise. Then the temperature will go even faster upwards," Bjordal says.
"You no longer have this calming effect of the clouds becoming more reflective. From that point on, the heating can go much faster," Storelvmo says.
She does not want to call it a tipping point, a concept that climate scientists are very concerned about, a point where there is no going back.
"But you can imagine that you cross a border into a climate system that is more sensitive to greenhouse gases than you had with this brake pad," Storelvmo says.
"This means that we should preferably avoid reaching this point. We would rather be where we still have our brake pad," she says.
It is currently not possible to determine exactly when this will happen or exactly what it takes for us to avoid ending up there. But it fits into the series of warnings from climate scientists.
"The hotter it gets, the faster it will go, and the harder it will be to stop the warming," Bjordal says.
More information: Jenny Bjordal et al. Equilibrium climate sensitivity above 5 °C plausible due to state-dependent cloud feedback, Nature Geoscience (2020). DOI: 10.1038/s41561-020-00649-1
Journal information: Nature Geoscience
Provided by University of Oslo
Why clouds are the missing piece in the climate change puzzle
Another study says warming may be worse than experts think
A better understanding of how cirrus clouds form
Cutting pollution won't cause global warming spike, study finds
Thin tropical clouds cool the climate
Clouds' response to pollution clarified with new climate analysis
Researchers model regional impacts of specific anthropogenic activities, their influence on extreme fire weather risk
Geologic history written in garnet sand
600-year-old marine sponge holds centuries-old climate records
Greenland melting likely increased by bacteria in sediment
A close look at forest fire smoke yields new clues about air pollution


text:
00 hours There was more efficient use of the entire theatre bloc
00 hours. There was more efficient use of the entire theatre block, suggesting a significant cultural change. Staff satisfaction was BI 2536 in vivo high. On-site consultant-driven surgical leadership has provided significant positive change to the provision of acute surgical care in our institution. The paradigm shift in acute surgical care has improved patient and theatre management and stimulated a cultural change of efficiency."
"A high-fat diet (HFD) can increase hypothalamic galanin (GAL). GAL has recently been shown to inhibit opiate reward, which in turn, decreases cAMP response element-binding protein (CREB) in the nucleus accumbens (NAc).
We hypothesized that injection of GAL into the paraventricular nucleus (PVN), or consumption of a selleck compound HFD, would be associated with a decrease in NAc CREB. In Exp. 1, GAL in the PVN of naive rats decreased phosphorylated-CREB (pCREB) which is the activated form of CREB, in the NAc compared to saline-injected controls. In Exp. 2, rats fed ad libitum HFD for 4 weeks had reduced NAc pCREB levels compared to rats with sporadic tastes of the HFD. Body weight, serum triglyceride and leptin levels were also raised in the chronic HFD-fed rats. These data suggest that PVN GAL or chronic intake of a HFD can decrease NAc pCREB. The implications of these findings may help to explain the lack of opiate-like withdrawal that has been reported in response to overeating a HFD, thereby
providing a potential mechanism underlying behavioral differences seen with addiction-like overconsumption of different types of
palatable foods. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved."
"Multiple mTOR inhibitor myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM-induced bone disease and forms a vicious cycle' of tumour development and bone destruction, intensified by suppression of osteoblast activity and promotion of osteoclast activity. In this paper, a mathematical model is proposed to simulate how the interaction between MM cells and the bone microenvironment facilitates the development of the tumour cells and the resultant bone destruction. It includes both the roles of inhibited osteoblast activity and stimulated osteoclast activity. The model is able to mimic the temporal variation of bone cell concentrations and resultant bone volume after the invasion and then removal of the tumour cells and explains why MM-induced bone lesions rarely heal even after the complete removal of MM cells. The behaviour of the model compares well with published experimental data. The model serves as a first step to understand the development of MM-induced bone disease and could be applied further to evaluate the current therapies against MM-induced bone disease and even suggests new potential therapeutic targets. (c) 2014 The Authors.
(C) 2013 Elsevier Espana, S L and SEMICYUC All rights reserved
(C) 2013 Elsevier Espana, S.L. and SEMICYUC. All rights reserved."
"Localized amyloidosis is characterized by amyloid protein deposition restricted to one organ or tissue without systemic involvement. TEW-7197 Gastrointestinal manifestations of localized amyloidoma are unusual, which makes amyloidoma restricted to the rectum a very rare diagnosis requiring a high index of suspicion. We present a rare account for rectal amyloidoma with an unusual presentation of obstructive symptoms and its treatment using a sophisticated surgical modality, transanal endoscopic microsurgery (TEM), which resulted in complete excision of the lesion without hospitalization and complications. The successful treatment
for this rectal amyloidoma using TEM emphasizes the need to broaden its application in the treatment
of various rectal lesions while preserving organ function and decreasing recurrence."
"The International Chemical Identifier (InChI) has been used to construct InChI-based optimal descriptors to model the binding affinity for fullerene[C60]-based inhibitors of human immunodeficiency virus type 1 aspartic protease (HIV-1 PR). Statistical characteristics of the one-variable model obtained by the balance of correlations are as follows: n = 8, r(2) = 0.9769, q(LOO)(2) = 0.9646, s = 0.099, F = 254 (subtraining set); n = 7, r(2) = 0.7616, s = 0.681, F = 16 (calibration set); n = 5, r(2) = 0.9724, s = 0.271, F= 106, R(m)(2) = 0.9495 (test set). Predictability of this approach has been checked with Protein Tyrosine Kinase inhibitor three random splits of the data: into the subtraining set, calibration set, and test set. (C) 2009
Elsevier Masson SAS. All rights reserved."
"Neutralizing antibodies (NABs) against IFN beta should be measured in specialized laboratories, using a test of inhibition of the cytopathic effect (bioassay or CPE test), based on the capacity of IFNss to block the infection of live monolayer-cultured cells by a virus, depending Sapanisertib chemical structure on the presence or absence of NABs. The European Federation of Neurological Societies (EFNS) considers this assay to be the gold standard. However, the various different ways to perform this assay complicate comparison of the results between laboratories. The World Health Organization (WHO) has published several recommendations to perform this assay using the A549 cell line and the murine encephalomyocarditis virus (EMCV). In order to validate the results previously obtained in our laboratory with HEP2/VSV, we undertook a comparative analysis of the two bioassays, HEP2/VSV and A549/EMCV, to assess whether the use of different cell lines and viruses influences sensitivity. We also calibrated the A549/EMCV assay with a reference IFNss. Our results confirm that the bioassay with HEP2/VSV is as sensitive as the assay with A549/EMCV and that a significant association and correlation exist in the results between both assays.
Three mouse phenotypes (wildtype, T-cell-deficient nude mice, and
Three mouse phenotypes (wildtype, T-cell-deficient nude mice, and nude mice reconstituted with T-cells taken from wildtype mice) were infected with one of two parasite clones (AS or AJ). Under a Bayesian framework, we use an adaptive population-based ACY-738 cell line Markov chain Monte Carlo method
and fit a set of dynamical models to observed data on parasite and red blood cell (RBC) densities. Model fits are compared using Bayes' factors and parameter estimates obtained. We consider three independent immune mechanisms: clearance of parasitised RBCs (pRBC), clearance of unparasitised RBCs (uRBC), and clearance of parasites that burst from RBCs (merozoites). Our results suggest that the immune response of wildtype mice is associated with less destruction of uRBCs, compared to the immune response of nude mice. There is a greater degree of synchronisation between pRBC and uRBC clearance
than between either mechanism and merozoite clearance. In all three mouse phenotypes, control of the peak of parasite density is associated with pRBC clearance. In wildtype mice and AS-infected nude mice, control of the peak is also associated with uRBC clearance. Our results suggest that uRBC clearance, rather than RBC infection, is the major mTOR inhibitor determinant of RBC dynamics from approximately day 12 post-innoculation. During the first 2-3 weeks of blood-stage infection, immune-mediated clearance of pRBCs and uRBCs appears to have a much stronger effect than immune-mediated
merozoite clearance. Upregulation of erythropoiesis is dependent on mouse phenotype and is greater in wildtype and reconstitited mice. Our study highlights the informative power of statistically rigorous model-fitting techniques in elucidating biological systems."
"American foulbrood (AFB) caused by Paenibacillus larvae is a bacterial disease in honey bee larvae that is observed worldwide. The aim of this study was to detect P. larvae in honey and beeswax samples from the suspected hives by direct PCR and culture growth. AF6 BMS-754807 inhibitor and AF7, the most sensitive pair of primers, were used to identify the DNA of P. larvae. A total of 100 suspected honey and beeswax samples collected from 25 different enterprises were examined. P. larvae were identified in 7 samples out of 8 by the PCR positive in total. Eight suspected larvae of honeybees were found positive by PCR. A suspected culture-negative sample was found positive through evaluation with PCR. One beeswax sample and seven honey samples were detected as positive for the larvae in the direct PCR detection."
"Purpose: This randomized trial compared 6- and 12-month outcomes of a home-based psychoeducational program to mailed information provided to 159 survivors of stroke (SS) and their spousal caregivers (CG). Methods: SS (age 50+) and CG were recruited as dyads post-discharge from inpatient rehabilitation. All dyads received mailed information for 12 months.
Methods: The framework comprises a number of logically connec
\n\nMethods: The framework comprises a number of logically connected steps. The first step utilizes multimodal registration of MRI and CT to map 2D boundary delineations of the prostate from MRI onto corresponding CT images, for a set of training studies. Hence, the scheme obviates the need for expert delineations CA3 Stem Cells & Wnt inhibitor of the gland on CT for explicitly constructing a SSM for prostate segmentation on CT. The delineations of the prostate gland on MRI and CT allows for 3D reconstruction of the prostate shape which facilitates the building of the LSSM. In order to perform concurrent
prostate MRI and CT segmentation using the LSSM, the authors employ a region-based level set approach where the authors deform the evolving prostate boundary to simultaneously fit to MRI and CT images in which voxels are classified to be either part of
the prostate or outside the prostate. The classification is facilitated by using a combination of MRI-CT probabilistic spatial atlases and a random forest classifier, driven by gradient and Haar features.\n\nResults: The authors acquire a total of 20 MRI-CT patient studies and use the leave-one-out strategy to train and evaluate four different LSSMs. First, a fusion-based LSSM (fLSSM) is built using expert ground truth delineations of the prostate on MRI alone, where the ground truth for the gland on CT is obtained via coregistration of the corresponding MRI and CT slices. The authors compare the fLSSM against another
LSSM (xLSSM), where expert delineations AZD7762 solubility dmso of the gland on both MRI and CT are employed in the model building; xLSSM representing the idealized LSSM. The authors also compare the fLSSM against an exclusive CT-based SSM (ctSSM), built from expert delineations of the gland on CT alone. In addition, two LSSMs trained using trainee CFTR inhibitor delineations (tLSSM) on CT are compared with the fLSSM. The results indicate that the xLSSM, tLSSMs, and the fLSSM perform equivalently, all of them out-performing the ctSSM.\n\nConclusions: The fLSSM provides an accurate alternative to SSMs that require careful expert delineations of the SOI that may be difficult or laborious to obtain. Additionally, the fLSSM has the added benefit of providing concurrent segmentations of the SOI on multiple imaging modalities. (C) 2012 American Association of Physicists in Medicine. [http://dx.doi.org.library.tamiu.edu:2048/10.1118/1.3696376]"
"Numerous studies reported that developmental dyslexia in alphabetic languages was associated with a wide range of sensorimotor deficits, including balance, motor skill and time estimation, explained by skill automatization deficit hypothesis. Neural correlates of skill automatization deficit point to cerebellar dysfunction. Recently, a behavioral study revealed an implicit motor learning deficit in Chinese children with developmental dyslexia in their left hands, indicating left cerebellar dysfunction.
difference was calculated by Review Manager 5 0 soft
difference was calculated by Review Manager 5.0 software and Stata 12. Twenty-four studies met the inclusion criteria of LN evaluation. 2,015 patients were involved in VATS group in contrast to 3,250 patients in thoracotomy group. The same number of total nodes stations (mean difference, 0.09; 95 % CI -0.25 to 0.42; P = 0.61) and mediastinal node stations (mean difference, -0.11; 95 % CI -0.24 to 0.01; P = 0.08) could be assessed by thoracotomy and VATS. The same number of N1 LNs (mean difference, -0.33; 95 % CI -0.70 to 0.05; P = 0.09) could be assessed by both groups. While more total (mean difference, -1.41; 95 % CI -1.99 to -0.83; P smaller than 0.00001) and mediastinal LNs (mean difference, -1.03; 95 % CI -1.81 to -0.24; P = 0.01) could be harvested by thoracotomy. Outcome showed that the same number of total and mediastinal Repotrectinib LN stations could be harvested by VATS and OT.
The same number of N1 LNs could be harvested by VATS and OT, while less total and mediastinal LNs could be harvested by VATS."
"Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor superfamily, whose members are capable of inducing apoptosis and inflammation. Endoplasmic reticulum stress (ERS) plays a key role in immune surveillance in macrophages. TRAIL mRNA and protein expression have previously been detected in macrophages; however, whether ERS has any effects on TRAIL expression in macrophages has not yet been determined. Here, we selleckchem demonstrate that thapsigargin (TG) and tunicamycin (TM), two ERS inducers activated macrophages were able to increase TRAIL mRNA and protein expression in RAW264.7 macrophages, the culture supernatant of THP-1 cells, and mouse peritoneal macrophages, indicating that ERS as a potent inducer of TRAIL transcription and expression in macrophages. This effect was blocked by the specific JNK inhibitor SP600125 and transcription factor AP-1 inhibitor SR 1130.
Interestingly, at the molecular level, regulation of TRAIL expression by ERS was accompanied by a significant Etomoxir cell line decrease in cytokine signaling suppressor 3 (SOCS3). SOCS3 siRNA clearly increased the expression of TRAIL mRNA and protein under ERS by activating the AP-1 components phosphorylated c-Jun and phosphorylated c-Fos in RAW264.7 cells. In contrast, over-expression of SOCS3 reversed ERS-induced TRAIL expression. These findings provide in vitro evidence that SOCS3 plays a critical negative role in the regulation of ERS-induced TRAIL expression via the Jun N-terminal kinase/AP-1 signaling pathway in macrophages."
"In this subacute toxicity study, ethyl methanesulfonate (EMS) was administered daily by oral gavage to SPF-bred Wistar rats of both sexes at dose levels of 20, 60 and 180/120 mg/kg body weight (bw)/day for a period of 28 days (for 19 days in the high-dose group). A control group was treated similarly with the vehicle, bidistilled water, only.
Because mutants in rigidity sensing show no detectable
displacement on 0.5-mu mdiameter pillars, there is a correlation between local contractions to 60 nm and rigidity sensing. Localization of myosin between submicron selleck kinase inhibitor pillars demonstrates that submicron scale myosin filaments can cause these local contractions. Finally, submicron pillars can capture many details of cellular force generation that are missed on larger pillars and more closely mimic continuous surfaces."
"Marcanine A was isolated from the stems of Polyalthia plagioneura as light yellow crystals. The molecular and crystal structures have been determined by 1D, 2D-NMR and X-ray diffraction analysis. It crystallizes in the triclinic system, space group P-1 with a = 5.2140(5)angstrom, b = 10.1871(11)angstrom, c = 11.0709(13)angstrom, alpha = 110.452(2)degrees, beta = 103.376(2)degrees gamma = 90.1870(10)degrees,
V = 533.74(10)angstrom(3), Z = 2. There are three intermolecular hydrogen bonds in a unit cell. It displays some inhibitory activities towards four kinds of human tumor cells, including BEL-7402, K562, SPCA-1and SGC-7409."
"Background. In some subjects with suspected asthma who have normal spirometry, administration of bronchodilators (BD) improves expiratory flow rates. The predictive value of this phenomenon in adults is not known. JNK inhibitor Objectives. To evaluate the predictive value of the response to SN-38 supplier BD for bronchial hyper-responsiveness (BHR) using the metacholine challenge test (MCT). Patients and methods. The study population included 62 non-smoking adult patients (41.9% women) 29.5 +/- 15.5 years of age (range 18-64 years) with suspected asthma with normal spirometry that underwent MCT within 1 week. The response to BD (200 g inhaled salbutamol) was compared between subjects with positive and negative MCT using cutoff levels of provocative
concentrations of metacholine causing a 20% decrease in forced expiratory volume in 1 second (FEV1) (PC20) of 4 and 8 mg/mL. Results. Mean (+/- SD) baseline FEV1 was 87.8 +/- 12% of predicted. After BD administration the mean FEV1 increased by 4.3 +/- 3.9%. The prevalence of BHR was 17.7% and 25.8% for PC20 for PC20 of 4 mg/mL and 8 mg/mL, respectively. The post-BD FEV1 increment for subjects with positive and negative MCT tests was 3.9% +/- 3.3% versus 4.4% +/- 4.1%, respectively; p = 0.89, using cutoff of 4 mg/mL. The corresponding figures for cutoff of 8 mg/ml were 4.3% +/- 3.1% vs. 4.3% +/- 4.2%, respectively; p = 0.8465. There was no correlation between post-BD FEV1 increment and PC20 values in patients with positive MCT test for the above-mentioned cutoff levels (correlation coefficient r = 0.1645, p = 0.6289; and r = 0.2417, p = 0.4051, respectively). Conclusions. In adults with suspected asthma who have normal spirometry, the response to BD cannot be used to predict BHR.
CHF patients compared with control subjects were similar with res
CHF patients compared with control subjects were similar with respect to myoglobin concentration: type I fibers 0.69 +/- 0.11 mM (mean +/- SD), type II fibers 0.52 +/- 0.07 mM in CHF vs. type I fibers 0.70 +/- 0.09 mM, type II fibers 0.49 +/- 0.07 mM in control, whereas SDH activity was significantly lower in CHF in both fiber types (P < 0.01). The myoglobin concentration in type I fibers
was higher than in type II fibers (P < 0.01). Consequently, the oxygen buffering capacity, calculated from myoglobin concentration/ SDH activity was increased in CHF: type I fibers 11.4 +/- 2.1 s, type II fibers 13.6 +/- 3.9 s in CHF vs. type I fibers 7.8 +/- 0.9 s, type II fibers 7.5 +/- 1.0 s in control, all P < 0.01). The click here calculated extracellular oxygen tension required to prevent core anoxia (PO(2crit)) in muscle fibers was similar when
controls were compared with patients in type I fibers 10.3 +/- 0.9 Torr in CHF and 11.5 +/- 3.3 Torr in control, but was lower NCT-501 in type II fibers of patients 6.1 +/- 2.8 Torr in CHF and 14.7 +/- 6.2 Torr in control, P < 0.01. The lower PO(2crit) of type II fibers may facilitate oxygen extraction from capillaries. Reduced exercise tolerance in CHF is not due to myoglobin deficiency."
"In patients who develop fulminant cerebral edema and elevated intracranial pressures, viral encephalitis can result in devastating neurological and cognitive sequelae despite antiviral therapy. The benefits of decompressive craniectomy, if any, in this group of patients are unclear. In this manuscript, the authors report their experience with 2 patients who presented with herpes simplex virus requiring surgical
decompression resulting in excellent neurocognitive outcomes. They also review the literature on decompressive craniectomy in patients with fulminating infectious encephalitis.\n\nFour Ulixertinib mouse published articles consisting of 13 patients were identified in which the authors had reported their experience with decompressive craniectomy for fulminant infectious encephalitis. Herpes simplex virus was confirmed in 6 cases, Mycoplasma pneumoniae in 2, and an unidentified viral infection in 5 others. All patients developed clinical signs of brainstem dysfunction and underwent surgical decompression resulting in good (Glasgow Outcome Scale [GOS] Score 4) or excellent (GOS Score 5) functional recoveries.\n\nThe authors conclude that infectious encephalitis is a neurosurgical disease in cases in which there is clinical and imaging evidence of brainstem compression. Surgical decompression results in excellent recovery of functional independence in both children and adults despite early clinical signs of brainstem dysfunction."
"Caspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic lethality in mice due to defects in endothelial tissues.
05) This study gives promising results concerning the normal com
05). This study gives promising results concerning the normal composition of PF and will be useful in the assessment of PF in diseased camels. (C) 2013 Elsevier B.V. All rights reserved."
"To compare the observation and analyzed on clinic effect of root canal preparation using Protaper ultrasonic machine Ni-Ti files (A group), Protaper hand Ni-Ti files (B group) and standard hand stainless
steel K-files (C group). A total of 180 teeth of 159 elder patients were randomly assigned to three groups, and then root canal preparation is taken for 60 teeth of each group respectively. Quisinostat The Protaper ultrasonic machine Ni-Ti files (A group) made good root canal shape after preparation in a safe and labor-saving method within a shorter time, and removed the debris and contamination level in the root canal thoroughly, It got significant differences from hand Ni-Ti files (B group) and hand stainless steel K-files (C group). As to dentine debris pushed out of apical foramen and solution quality and intraoperative reaction, Protaper ultrasonic
machine Ni-Ti file group was less than Protaper hand Ni-Ti file group (P<0.05); Protaper hand Ni-Ti file group was less than stainless steel K-file group (P<0.05). Significant differences existed among them. Compared with Protaper ultrasonic machine Ni-Ti files (A group), hand files (B0C group) can save more labor and time With less medical complications in the https://www.selleckchem.com/products/azd-1208.html process of elder root canal preparation, as well as less substances pushed out of apical foramen. Root canal treatment high success
rate."
"Nitration of 1-methoxy naphthalene with cerium (IV) ammonium nitrate in acetic acid gives a complex mixture of six nitro derivatives. Among the six compounds, five are known earlier and one is an unusual new dimer, 1,1′-dimethoxy-4,4′-dinitro-2,2′-binaphthyl, formed by the oxidative find protocol biradical coupling. The formation of 1,1′-dimethoxy-4,4′-dinitro-2,2′-binaphthyl is further confirmed by its reduction to 4,4′-diamino1,1′-dimethoxy-2,2′-binaphthyl."
"Acoustically sensitive emulsion droplets composed of a liquid perfluorocarbon have the potential to be a highly efficient system for local drug delivery, embolotherapy, or for tumor imaging. The physical mechanisms underlying the acoustic activation of these phase-change emulsions into a bubbly dispersion, termed acoustic droplet vaporization, have not been well understood. The droplets have a very high activation threshold; its frequency dependence does not comply with homogeneous nucleation theory and localized nucleation spots have been observed. Here we show that acoustic droplet vaporization is initiated by a combination of two phenomena: highly nonlinear distortion of the acoustic wave before it hits the droplet and focusing of the distorted wave by the droplet itself.
"Vascular complications of wrist arthroscopy are rare We
"Vascular complications of wrist arthroscopy are rare. We report the case of a 42-year-old male patient with a history of hemophilia who had a ganglion located where the radial pulse is taken that had been causing him pain for five months. After infusion of Exacyl (antifibrinolytic agent), the ganglion was drained arthroscopically. Fifteen days later, the patient presented with a pseudoaneurysm of the radial artery requiring urgent reoperation. (C) 2014 Elsevier Masson SAS. All rights reserved."
"Zingiber officinule (ZO), commonly known
as ginger, has been traditionally used in the treatment of diabetes mellitus. Several studies have reported the hypoglycaemic properties of ginger in animal models. The present study evaluated selleck the antihyperglycaemic effect of its aqueous extract administered orally (daily) in three different doses (100, 300, 500 mg/kg body weight) for a period of 30 d to streptozotocin (STZ)-induced diabetic rats. A dose-dependent antihyperglycaemic effect revealed a decrease of plasma glucose levels by 38 and 68% on the 15th and 30th day, respectively, after the rats were given 500 mg/kg. The 500 mg/kg ZO significantly (P<0.05) decreased kidney weight (%
body weight) in ZO-treated diabetic rats v. control rats, although the decrease in liver weight (% body weight) was not statistically significant. Kidney glycogen content increased significantly (P<005) while liver and skeletal muscle glycogen content decreased significantly (P<005) in diabetic controls v. normal controls. ZO (500 mg/kg) also significantly decreased kidney glycogen (P<005) selleck chemicals llc and increased liver and skeletal muscle glycogen in STZ-diabetic rats when compared to diabetic controls. Activities of glucokinase, phosphofructokinase and pyruvate kinase in VX-680 ic50 diabetic controls were decreased by 94, 53 and 61 %, respectively, when compared to normal controls; and ZO significantly increased (P<0.05) those enzymes' activities
in STZ-diabetic rats. Therefore, the present study showed that ginger is a potential phytomedicine for the treatment of diabetes through its effects on the activities of glycolytic enzymes."
"The biological threat imposed by orthopoxviruses warrants the development of safe and effective vaccines. We developed a candidate orthopoxvirus DNA-based vaccine, termed 4pox, which targets four viral structural components, A33, B5, A27, and L1. While this vaccine protects mice and nonhuman primates from lethal infections, we are interested in further enhancing its potency. One approach to enhance potency is to include additional orthopoxvirus immunogens. Here, we investigated whether vaccination with the vaccinia virus (VACV) interferon (IFN)-binding molecule (IBM) could protect BALB/c mice against lethal VACV challenge. We found that vaccination with this molecule failed to significantly protect mice from VACV when delivered alone.
(J Trauma Acute Care Surg 2013;75:871-877 Copyright (C) 2013
(J Trauma Acute Care Surg. 2013;75:871-877. Copyright (C) 2013
by Lippincott Williams & Wilkins)"
"Society's increased interest in renewable energy and materials put pressure on forest biomass production. Intensive fertilization of young Norway spruce (Picea abies) forest has a considerable potential to increase the production of tree biomass, but there are concerns about negative side-effects on forest ecosystem structure and function. Fertilization of young forest has a strong negative impact on light availability below the tree canopy and reduces the abundance of the forest floor vegetation. The silvicultural practice of thinning has been shown to affect composition and diversity of forest floor vegetation, EPZ5676 and it has been proposed, but C59 nmr rarely tested, that the effects of fertilization are interdependent on the type of thinning performed. Here we present responses on the forest floor vegetation following 25 years of fertilization and eighth years after thinning (removing 30% or 60% of the tree basal area) in a Norway spruce forest in northern Sweden. Fertilization without thinning led to a considerable reduction in abundance of most forest floor plants. It did not affect species richness but resulted in an increased evenness. Thinning reduced the fertilization effects
so that the total abundance of the vegetation was comparable to the unfertilized control plots. A considerable change in species composition had, however, taken place. Thinning favored early-successional species and pteridophytes on the account of dwarf-shrubs. Thinning
also increased species richness and functional richness, while none, or negative effects were seen on evenness and functional evenness, respectively. A comparison PRT062607 cell line with data from the National Forest Inventory revealed that the type of vegetation generated by fertilization, without or in combination with thinning, is a type of vegetation very uncommon in Swedish boreal forests. First, we conclude that the effects of fertilization on forest floor vegetation in young stands of Norway spruce are largely dependent on thinning regime. Secondly, fertilization will, independently of thinning, lead to considerable changes in the vegetation, including a functional shift from dwarf-shrubs with ericoid mycorrhiza to ferns and grasses with arbuscular mycorrhiza, resulting in a functional type of vegetation that is rare in this part of the boreal forest biome. Finally, in contrast to what previously has been suggested for unfertilized forests, thinning of fertilized forests may not promote late-successional species. (C) 2013 Elsevier B.V. All rights reserved."
"We studied the intracerebral dynamics of developing skills for self-regulation of psychophysiological functions in the biofeedback game model via functional MRI.


text:
Ohio House puts off vote on Davis-Besse bill until Aug. 1
COLUMBUS - The Ohio Senate passed House Bill 6 Wednesday, but the Ohio House of Representatives moved to suspend voting on the bill until Aug. 1, Ottawa County Commissioner Mark Stahl said late Wednesday evening.
The bill passed out of the Ohio Senate's energy committee Wednesday afternoon and went to the full Senate for a vote later in the day.
Stahl provided updates from Columbus on the bill's progress to the News-Messenger.
He said he didn't know exactly when the Senate would vote on the bill, or whether it would ultimately land on Gov. Mike DeWine's desk to be signed Wednesday evening or later in the week.
The commissioner said the version of the bill that passed 9-4 in the Senate's energy committee had an amendment attached to it that would help residents who were unable to pay their bills.
Stahl said the bill, if passed by the Senate, would need to go through a House and Senate conference committee before it reached the governor's desk.
The Cincinnati Enquirer reported July 2 that the latest version of HB 6 would give up to $150 million a year to FirstEnergy Solutions, which operates the two nuclear plants, starting in 2020.
That's less than what the House planned to offer: the lion's share of $197.6 million collected in fees on utility bills, starting in 2019.
If approved, FirstEnergy Solutions would get that $150 million in 2020 and the Public Utilities Commission of Ohio would audit the company's finances starting in 2021.
Under the Senate plan, each residential customer would pay 80 cents per month on utility bills — less than the $1 a month the House proposed.
Tom Becker, spokesman for FirstEnergy Solutions, said earlier this month that while the company is optimistic about HB 6's outcome, FES remains unable to purchase the fuel required for Davis-Besse's next refueling cycle without legislative support.
Becker added that should FES receive the long-term certainty that comes with an affirmative vote by the Ohio Legislature, the company will immediately evaluate its options.
Becker could not be reached for comment Wednesday.
Daniel Sawmiller, Ohio energy policy director for the Natural Resources Defense Council, said after the Senate vote that Ohio was the only state in the country bailing out extremely old coal and nuclear plants and paying for it by gutting its clean energy standards.
"This bill is a giant step backwards for Ohio and we will see the consequences for years to come as our bills rise and our clean energy jobs plummet. Other states in the region will certainly appreciate the opportunity to hoover up the jobs coming out of the growing clean energy sector," Sawmiller said.
Twitter: @DanielCarson7


Although stroke occurs rarely in cirrhotic patients, liver cirrhosis is associated with an elevated risk of developing subarachnoid or intracranial haemorrhage, a recent meta-analysis has shown.
In elderly adults with pneumonia, cirrhosis appears to be correlated with mortality and rehospitalization, a new study has found.
The use of direct-acting antivirals to treat hepatitis C virus (HCV) infection appears to also reduce the risk of cardiovascular disease events, a recent study has found.
Management of locally advanced hepatocellular carcinoma aims to improve survival and to maintain the quality of life of patients, with less likelihood of cure due to the advanced nature of disease. Upon diagnosis of the severity of liver cancer, offering appropriate and proven treatment options is important to extend the survival of these patients.
At the recent Annual Scientific Congress of the Malaysian Society of Gastroenterology and Hepatology (GUT 2016), held at Shangri-La Hotel, Kuala Lumpur, an expert from Hong Kong spoke on the role of direct-acting antivirals as well as pan-genotypic agents that are set to revolutionize hepatitis C treatment.
An expert panel meeting on hepatorenal syndrome (HRS) was recently convened in Kuala Lumpur with the aim of discussing management practices in different hospital settings. Chaired by Professor Sanjiv Mahadeva, consultant gastroenterologist, University Malaya Medical Centre, the meeting saw local and regional experts share HRS cases they have encountered in their practice.
Cabozantinib, an oral inhibitor of multiple tyrosine kinases, significantly improves overall survival (OS) and progression-free survival (PFS) in patients with advanced hepatocellular carcinoma (HCC) whose disease progressed following sorafenib or other systemic therapies.
Virtual hepatic venous pressure gradient (vHVPG), a novel noninvasive approach to assess portal hypertension, is shown to correlate well with the gold-standard invasive method in a recent Chinese study.
An index of three liver-specific microRNAs (the MiR-B Index) could serve as a biomarker of spontaneous or treatment-induced transition from active to inactive chronic hepatitis B virus (HBV) infection, facilitating disease monitoring and testing of new antivirals, according to Dr Mauricia Brunetto from the University of Pisa, Italy, who spoke recently at the Asian Pacific Digestive Week (APDW) 2017 in Hong Kong.
A new technology involving the use of monocyte-derived hepatocyte-like (MH) cells has demonstrated high sensitivity and specificity in the diagnosis of idiosyncratic drug-induced liver injury (DILI), data presented at the Asian Pacific Digestive Week (APDW) 2017 held in Hong Kong have shown.


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