Heart disease is the third most common cause of maternal death, and 20% of the patients suffering from cardiac disease have severe haemodynamic instability related to the underlying cardiac problem. Parturients with cardiac disease often undergo surgery and neuraxial anaesthesia for various reasons and in different trimesters. There are few reports in the literature describing the management of parturients with cardiac disease during neuraxial anaesthesia. This article reviews current data and discusses important aspects of heart disease in relevance to neuraxial anaesthesia in a parturient. As labour and delivery are the most important aspect of pregnancy, the major focus of this article is on this segment.
The physiological changes occurring in the cardiovascular system due to pregnancy are exaggerated in the presence of a cardiac lesion., These cardiovascular changes along with coagulation abnormalities may discourage the use of neuraxial blockade due to the sympathetic blockade produced with the resulting haemodynamic changes. The author searched electronic databases including the following: MedLine, PubMed, and the Cochrane Central register of controlled clinical trials (until June 2018) and applied the following search terms: neuraxial block, spinal and epidural anaesthesia (EA), heart disease, surgery, and pregnant patient. Only the relevant English literature reports are considered in this review.
Approximately 60%–80% of parturients suffering from cardiac disease have congenital heart disease. The commonest ones are tetralogy of Fallot, septal defects, and Eisenmenger's syndrome. Valvular heart disease comprises 15% cases, of which rheumatic mitral stenosis is the most common. [Table 1] lists the common cardiac diseases in which successful use of neuraxial anaesthesia has been performed.
Hypercoagulability associated with pregnancy and the possible need for anticoagulation (e.g., patients in chronic atrial fibrillation (AF), prosthetic heart valve, and pulmonary thromboembolism) increase the risk of thrombosis or bleeding during neuraxial block. [Table 2] represents the major haemodynamic changes in different cardiac conditions.
Apart from the physiological responses towards pregnancy and delivery, the other factors that affect haemodynamic status during neuraxial block include gestational age, intravascular fluid status, positioning of the patient, and the route, dose, and choice of uterotonic agents.
Not all the parturients suffering from cardiac disease are fit to undergo a neuraxial block. The following lines depict some indications and contraindications of neuraxial anaesthesia in parturients with cardiac disease.
Parturient may require neuraxial anaesthesia during labour, delivery, or during the second trimester for procedures such as appendicectomy and ovarian cyst removal. Many reports have been published of successful administration of neuraxial blockade in parturient with cardiac disease coming for these procedures.
A detailed evaluation of the underlying cardiac problem including risk stratification is essential to consider for extensive monitoring/switch over to general anaesthesia and need for the help of a specialised team with experience of cardiovascular anaesthesia and intraoperative echocardiography. Pertinent cardiac testing (angiography, computerised tomography, or magnetic resonance imaging) apart from the routine echocardiography can determine the disorder that can affect the anaesthesia management. If available, serum β-type natriuretic peptide can be done for the parturient with the potential to develop heart failure during additional stress of surgery or anaesthesia. Patients with coartation of aorta are at increased risk of hypertension and ecampsia and neuraxial block should be avoided. Bleeding at the time of surgery/delivery is more common in patients having cyanotic heart disease and/or on anticoagulation.
Infective endocarditis (IE) prophylaxis is needed in parturient with highest risk of IE, for example, those with prosthetic heart valve, history of IE before, and with some complex congenital lesions. In high-risk parturient, the preferred regime is ampicillin 1.5 mg/kg (maximum 120 mg) given intravenously 30 min before neuraxial block followed by ampicillin 1 g given intravenously/intramuscularly or amoxicillin 1 g given orally 6 h later. The parturient needs to undergo some risk assessment scores, for example, CARPREG or ZAHARA and KHAIRY score to predict maternal cardiovascular events. Patients with NYHA class >II, with a prior cardiac event (heart failure, stroke, or arrhythmia), critical mitral or aortic stenosis, severe left ventricular dysfunction, presence of a valve prosthesis or severe pulmonary regurgitation, and smoking history have an increased risk of both maternal and neonatal events during the course of pregnancy, labour, and delivery.
The extensiveness of monitoring depends on the severity of disease. In case of mild disease, monitoring includes noninvasive blood pressure measurement, electrocardiography (ECG), tocodynamometry, and foetal HR monitoring. In moderate to severe disease, the following additional monitoring aids may be applied depending on the availability. External defibrillator paddles should be placed before surgery in patients especially prone to intractable tachyarrhythmia. Filter in all intravenous lines in patients with shunt lesion to prevent paradoxical air embolism.
Pulse oxymetry: For rapid detection of desaturation, for example, tetralogy of Fallot's patient developing hypercyanotic spell.
ECG: Continuous five lead monitoring and ST segment monitoring is required for the detection of myocardial ischemia in patients with aortic stenosis (AS), coronary artery disease (CAD), or hypertrophic obstructive cardiomyopathy (HOCM) or arrhythmia in other patients.
Intra-arterial catheter: In moderate to severe disease patients for minute-to-minute monitoring of arterial pressure, arterial blood gas sampling, and management of vasoactive drugs, if any.
Central venous pressure (CVP): In high-risk patients especially those who are prone to hypotension, pulmonary oedema, or peripartum haemorrhage, a CVP line is a guide to fluid therapy and administration of inotropes and vasodilators.
Pulmonary artery catheter: Rarely used, for example, in a patient with severe pulmonary hypertension in which it guides titration of pulmonary vasodilators.
Echocardiography: Have some role in assessment of ventricular function both pre and post surgery or delivery and direct visualisation of the ventricles to know the volume status.
Mitral stenosis is the commonest lesion in pregnancy in our country. The symptoms depend on the severity of stenosis. However, the usual features are breathlessness, palpitation, chest pain, haemoptysis, pulmonary oedema, and thromboembolism. Knowing the severity of mitral stenosis (MS) is of paramount importance [Table 4] to manage neuraxial block during labour and delivery. AF is common in parturients. An increase in HR decreases left ventricular filling time and thereby a fall in CO. This in combination with an increase in plasma volume as well as increase in preload (due to autotransfusion) following delivery may lead to pulmonary oedema. The anaesthetic goals in these parturients are as follows: maintenance of acceptable HR, immediate treatment of acute AF, avoidance of aortocaval compression, maintenance of adequate venous return and normal blood pressure, adequate analgesia, as well as avoidance of hypoxia, hypercarbia, and acidosis.
Combined spinal epidural with intrathecal opioid such as fentanyl in the first stage followed by titrated dose of local anaesthetic (LA) in the second stage is beneficial to prevent stress-related tachycardia. The addition of fentanyl to dilute LA mixture enhances the quality of analgesia without contributing to the sympathetic blockade. The fall in SVR in this stage is managed with small bolus (50–100 μg) of phenylephrine. Ephedrine is avoided unless there is relative bradycardia (HR <70/min). For a critically ill parturient, opioid alone may be administered through epidural/intrathecal route. Adequate perineal and segmental analgesia reduce stress-induced increase in HR and potentiate the urge to push. This allows foetal descent to be accomplished by uterine contractions and avoiding the deleterious effects of Valsalva maneuver during the second stage of labour. Low SA (when EA is not used) may be administered for a controlled second stage and delivery.
In moderate to severe disease, SA is avoided due to acute fall in SVR following the block. EA with titrated dose of LA is preferred over SA as the former results in better control of haemodynamic state due to slower onset of blockade. Prophylactic use of vasopressors and intravascular volume loading are best avoided. A careful titration of anaesthetic and analgesic dose allows judicious and appropriate volume supplementation in a critical parturient. These parturients are prone to hypotension not only because of EA, but also due to venous pooling, prior beta-adrenergic blockade, and diuretic therapy. About 50–100 μg of phenylephrine or 20–40 μg of metaraminol is used in case of hypotension with little or no untoward effect on uteroplacental circulation. Caution use of oxytocin is warranted.
Few details about the anticipated changes during neuraxial block in parturients with other cardiovascular disease, anaesthetic goals, and neuraxial block of choice that anaesthesiologists should know are described in [Table 5].
Postoperative analgesia in these cases is usually with an opioid or α-agonist or a combination of opioid and nonsteroidal anti-inflammatory drugs intravenously. Patient-controlled analgesia is an alternative mode of analgesia in these group of patients.
Optimal management during neuraxial anaesthesia requires a thorough assessment of the anatomic and functional capacity of the diseased heart along with an analysis of how the described major physiologic changes are likely to affect the specific limitations imposed by the intrinsic disease, patient's tolerance to pain during labour or surgery, impact of uterine contraction-induced autotransfusion, postpartum changes induced by relief of vena caval obstruction, potential for postpartum haemorrhage, and use of uterine oxytocic agents.
Elkayam U, Goland S, Pieper PG, Silverside CK. High-risk cardiac disease in pregnancy: Part I. J Am Coll Cardiol 2016;68:396-410.
Talbot L, Maclennan K. Physiology of pregnancy. Anaesth Intensive Care med 2016; 17:341-5.
Perloff JK. Pregnancy and congenital heart disease. J Am Coll Cardiol 1991; 18:340-2.
European Society of Gynecology (ESG), Association for European Paediatric Cardiology (AEPC), German Society for Gender Medicine (DGesGM), Regitz-Zagrosek V, Blomstrom Lundqvist C, Borghi C, et al. ESC guidelines on the management of cardiovascular diseases during pregnancy: The Task Force on the Management of Cardiovascular Diseases During Pregnancy of the European Society of Cardiology (ESC). Eur Heart J 2011; 32:3147-97.
Ziskind Z, Etchin A, Frenkel Y, Mashiach S, Lusky A, Goor DA, et al. Epidural anesthesia with the trendelenburg position for cesarean section with or without a cardiac surgical procedure in patients with severe mitral stenosis: A hemodynamic study. J Cardiothorac Anesth 1990; 4:354-9.
Rayburn WF, Fontana ME. Mitral valve prolapse and pregnancy. Am J Obstet Gynecol 1981; 141:9-11.
Sugrue D, Blake S, MacDonald D. Pregnancy complicated by maternal heart disease at the National Maternity Hospital, Dublin, Ireland, 1969 to 1978. Am J Obstet Gynecol 1981; 139:1-6.
Choi HJ, Chui L, Hurd JM, Tremper KK. Epidural anesthesia for a woman with severe aortic stenosis undergoing a cesarean section. Anesthesiol Rev 1992; 19:61.
Sen S, Chatterjee S, Mazumder P, Mukherji S. Epidural anesthesia: A safe option for cesarean section in parturient with severe pulmonary hypertension. J Nat Sci Biol Med 2016; 7:182-5.
Chohan U, Afshan G, Mone A. Anaesthesia for caesarean section in patients with cardiac disease. J Pak Med Assoc 2006; 56:32-8.
Duan R, Xu X, Wang X, Yu H, You Y, Liu X, et al. Pregnancy outcome in women with eisenmenger's syndrome: A case series from West China. BMC Pregnancy Childbirth 2016; 16:356.
Atanassoff PG, Schmid ER, Jenni R, Arbenz U, Alon E, Pasch T. Epidural anesthesia for a cesarean section in a patient with pulmonary atresia and ventricular septal defect. J Clin Anesth 1991; 3:399-402.
Solanki SL, Jain A, Singh A, Sharma A. Low-dose sequential combined-spinal epidural anesthesia for Cesarean section in patient with uncorrected tetrology of Fallot. Saudi J Anaesth 2011; 5:320-2.
Sharma SK, Gambling DR, Gajraj NM, Truong C, Sidawi EJ. Anesthetic management of a parturient with mixed mitral valve disease and uncontrolled atrial fibrillation. Int J Obstet Anesth 1994; 3:157-62.
Krenz EI, Hart SR, Russo M, Alkadri M. Epidural anesthesia for cesarean delivery in a patient with severe pulmonary artery hypertension and a right-to-left shunt. Ochsner J 2011; 11:78-80.
Slomka F, Salmeron S, Zetlaoui P, Cohen H, Simonneau G, Samii K, et al. Primary pulmonary hypertension and pregnancy: Anesthetic management for delivery. Anesthesiology 1988; 69:959-61.
Hands ME, Johnson MD, Saltzman DH, Rutherford JD. The cardiac, obstetric, and anesthetic management of pregnancy complicated by acute myocardial infarction. J Clin Anesth 1990; 2:258-68.
Rosenlund RC, Marx GF. Anaesthetic management of a parturient with prior myocardial infarction and coronary artery bypass graft. Can J Anaesth 1988; 35:515-7.
Ruys TP, Bekkers JA, Duvekot JJ, Roos-Hesselink JW. A pregnant patient with native aortic coarctation and aneurysm. Aorta (Stamford) 2014; 2:110-2.
Kim G, Ko JS, Choi DH. Epidural anesthesia for cesarean section in a patient with Marfan syndrome and dural ectasia – A case report- Korean J Anesthesiol 2011; 60:214-6.
Indira K, Sanjeev K, Sunanda G. Sequential combined spinal epidural anaesthesia for cesarian section inperipartum cardiomyopathy. Ind J Anaesth 2007; 51:137.
Ituk US, Habib AS, Polin CM, Allen TK. Anesthetic management and outcomes of parturients with dilated cardiomyopathy in an academic centre. Can J Anaesth 2015; 62:278-88.
Sinha R, Rewari V. Takayasu aortoarteritis with dilated cardiomyopathy: Anesthetic management of labor analgesia. Acta Anaesthesiol Taiwan 2010; 48:99-102.
Pryn A, Bryden F, Reeve W, Young S, Patrick A, McGrady EM, et al. Cardiomyopathy in pregnancy and caesarean section: Four case reports. Int J Obstet Anesth 2007; 16:68-73.
Shnaider R, Ezri T, Szmuk P, Larson S, Warters RD, Katz J, et al. Combined spinal-epidural anesthesia for cesarean section in a patient with peripartum dilated cardiomyopathy. Can J Anaesth 2001; 48:681-3.
Kasai H, Gohda Y, Sasaki K, Kemmotsu O. Anesthetic management of caesarean section in a patient with primary pulmonary hypertension. Masui 1988; 37:476-82.
Weitzel NS, Gravlee GP. Cardiac disease in the obstetric patient. In: Bucklin BA, Gambling DR, Wlody D, editors. A Practical Approach to Obstetric Anesthesia. Philadelphia: Lippincott Williams & Wilkins; 2009. p. 403-34.
Camann WR, Goldman GA, Johnson MD, Moore J, Greene M. Cesarean delivery in a patient with a transplanted heart. Anesthesiology 1989; 71:618-20.
Holzman RS, Nargozian CD, Marnach R, McMillan CO. Epidural anesthesia in patients with palliated cyanotic congenital heart disease. J Cardiothorac Vasc Anesth 1992; 6:340-3.
Carp H, Jayaram A, Vadhera R, Nichols M, Morton M. Epidural anesthesia for cesarean delivery and vaginal birth after maternal Fontan repair: Report of two cases. Anesth Analg 1994; 78:1190-2.
Monteiro RS, Dob DP, Cauldwell MR, Gatzoulis MA. Anaesthetic management of parturients with univentricular congenital heart disease and the Fontan operation. Int J Obstet Anesth 2016; 28:83-91.
Gogarten W, Vandermeulen E, Van Aken H, Kozek S, Llau JV, Samama CM, et al. Regional anaesthesia and antithrombotic agents: Recommendations of the European Society of Anaesthesiology. Eur J Anaesthesiol 2010; 27:999-1015.
Osta WA, Akbary H, Fuleihan SF. Epidural analgesia in vascular surgery patients actively taking clopidogrel. Br J Anaesth 2010; 104:429-32.
Bates SM, Greer IA, Hirsh J, Ginsberg JS. Use of antithrombotic agents during pregnancy: The seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 2004; 126:627S-44S.
Furui T, Kurauchi O, Oguchi H, Nomura S, Mizutani S, Tomoda Y, et al. Pregnancy and successful delivery in a patient with triple heart valve prosthesis. Int J Gynaecol Obstet 1993;41:89-92.


Our soundboy this week is DJ DISCROW.
It will be 2 years for me in October. I was back and forth to play gigs for about 5 years before that and it was always the plan to get over here fulltime. I had a few things to do back in Aus that I wanted to get done before I made the move so it was good motivation and I've never looked back!
HOW DOES THE MUSIC SCENE IN BALI DIFFER FROM BACK HOME?
It's just so much different. The diversity of tunes over here is amazing and the amount of venues you get to play good quality house music at is amazing.
YOU RECENTLY LANDED YOURSELF A SIGNIFICANT ROLE AT MRS SIPPY, TELL US ABOUT THAT AND THE VENUE ITSELF?
I recently took over the Music Director role at Mrs Sippy from Adam Bennetts who was at the helm for the first year since opening. We have really established Mrs Sippy as one of the major beach clubs in Bali now and everything is going really well at the moment with high season.
WHAT IS YOUR FAVORITE VENUE IN THE WORLD?
My favourite venue in the world is actually Mrs Sippy, but I also love Singlefin at Uluwatu – its hard to beat open air venues.
IF MONEY WAS NO OBJECT WHAT CAR OR MOTORBIKE WOULD YOU TREAT YOURSELF TO?
Right now, in Bali? Tough call - Probably a BMW x5.
IF DONALD TRUMP CAME TO MRS SIPPY AND CAME UP TO MAKE A REQUEST WHAT WOULD YOU SAY TO HIM?
Show me the money or get out of my face.
WHAT HAS BEEN THE MOST INCREDIBLE THING YOU HAVE SEEN FROM BEHIND A DJ BOOTH?
I have seen some crazy stuff over the last 12 years – most of which I can't say. Over the last year and half I have seen some great stuff (mainly backslams) off the 5m dive platform at Mrs Sippy every day.
WHAT'S YOUR SECRET SPOT IN BALI WHERE YOU GO TO ESCAPE?
Nusa Lembongan if I get a couple of days off to relax or 40thieves at night for a tasty cocktail and a boogie.
The locals getting paid more on average, especially at the bigger venues, these guys and gals work their buts off!!
Here's a mixtape from one of Dj Discrow's set at Mrs. Sippy! Press play and enjoy!


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When Is It Time to Redesign Your Packaging?
April 02, 2019 - by Cheryl Swanson
Knowing when to rebrand or redesign your packaging is often a tough decision. You don't want a situation like the one Tropicana had in 2009 when it redesigned its packaging and lost 20% of its sales in just two months. Ultimately, they went back to the original packaging after losing nearly $50MM on the redesign.
How do you avoid this kind of crisis? Here are some signs your brand is ready to be repackaged, re-launched, and re-energized.
Your brand was once an innovator, but has lost its edge with new consumers and is declining in the marketplace.
In 1982, Diet Coke was revolutionary for its great cola taste and zero calories. Today, however, Millennials want new taste adventures and design that speaks to them directly. After six quarterly declines for this #1 diet cola, the rebrand was born. Diet Coke modernized its flavors and packaging to address Millennial desires, while keeping the original Diet Coke intact for its diehard fans. It re-launched last year with four new flavors (Ginger Lime, Feisty Cherry, Zesty Blood Orange, and Twisted Mango) along with sleek, contemporary packaging. The rebrand and repackaging has been an amazing success, propelling Diet Coke to sales increases and a solid #1 in the diet cola wars.
Your brand is stuck with baggage – old, outdated perceptions that remain despite all efforts at modernization.
Prior to 2010, Old Spice was perceived as the "old" brand for "old guys" despite offerings like Red Zone and High Endurance, which were meant for a younger generation. (Remember the aftershave with the old schooner emblazoned on the front? Probably not…it's old.) After losing market share to Axe, Old Spice pivoted to younger men with hilarious commercials and equally tongue-in-cheek packaging. According to Landor (the design firm that did the redesign), they studied the "new manliness" and brought the cheeky new visual identity to all consumer touch-points. The result? Double-digit growth since the rebranding was launched.
You've become overly complex with too many products/line extensions/logo versions/graphics and colors.
Simplicity is the call to arms for successful branding now, so much so that the identity firm Siegel+Gale uses the word as its own core essence. It's in every touch-point of its communications. They have even created a "Simplest Brand" report, which talks to 15,000 people worldwide and not only measures the role of simplicity in brand experience but in the monetary value it brings. Simplicity affords clear communication and ease of "accessing" the brand's story. According to the report, "brands leave $98B on the table when they don't simplify". Globally, the top "simple" brand is Netflix, followed by Aldi and its private label packaging.
When you are suffering from a bad reputation.
McDonald's had a reputation for cheap, unhealthy, obesity-creating fast food. Its red packaging with golden arches became synonymous with this reputation, so McDonald's invested heavily in new packaging and restaurant design to become a more trusted and respected brand. Its new packaging still features the iconic golden arches, but with a clean, simple approach, including a white background that hints at the refreshed recipes and new, healthier offerings (like salads).
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redpajama_set_name: RedPajamaCommonCrawl


In this tutorial, I will show you how to configure VPN access and Dynamic DNS on your router. With these configuration you will be able to access your network from anywhere.
In this tutorial, I will show you how to completely block bitTorrent on your network.
In this tutorial, I will show you how to enhance your mangle rules for faster DNS resolution, Winbox, Google Play Services, optimized browsing and better router management.
In this tutorial, I will show you how to fix one of the most common queue issues by disabling fasttrack.
In this tutorial, I will show you how to use Mangle rules to mark packets that are passing through the router. I will be marking browsing, P2P and other packets. These marking will be used to create a queue tree (QOS).


He called me yesterday to talk through our new Sponsorship Welcome Packets I was putting together.
We talked for a long time about our partners and donors and our relationship with the people who make all our work overseas possible. Zambrano, Honduras took up quite a bit of our conversation and what it was like to minister and work with the beautiful people in Zambrano.
When we began discussing Tierra Bomba, Colombia, it was during that part of our conversation that I really got a sense for his heart. He talked about the overwhelming number of impoverished and starving children who live in the island community of Tierra Bomba. Our talk was about a church in Cartagena that wanted to partner with us to reach the people of Tierra Bomba with the message of hope in Jesus Christ.
If he physically and financially could, I think he would feed absolutely every child on the island of Tierra Bomba and every child in Honduras!
Our Founder and President, Ernie, has such a heart of compassion for these children and that is what I absolutely respect and love! He and his wife, Robyn, are fully committed to the work of feeding hungry children in other parts of the world. They lead by example by giving of their personal resources all the time to make sure that these children have the food they need. Every single penny that comes into ER International goes directly to helping these children both in Honduras and in Colombia.
To echo our Founder's words I have to ask myself and you, "How can I NOT feed these hungry children?"
I invite you to join me in support of the work of ER International. You can join us by giving a one time gift or by sponsoring a needy child for $22 per month.
Click on the "Give" link below and follow the prompts.
We are so grateful for all of our partners. Together we are making a difference in other parts of the world, one life at a time.


Would you like to donate an instrument to the BIG BLUE BAND?? See our donation page on the links located on the top left of this page!
Make a difference in a band member's life!
DONATE your gently used instruments today!
*Please bookmark this page and view it frequently for news, announcements, schedules, and photos of the BIG BLUE BAND.


This ribbon adds a simple and elegant finish to your gift packaging. The Simplicity Grosgrain Ribbon is lightweight, has a ribbed grosgrain texture and is 4mm wide, the perfect width for beautiful, delicate bows. It is double faced and features white edges surrounding a bold, single stripe down the center on both sides of the ribbon. Perfect for parties, gift wrapping, and crafts. Made of 100% Polyester.


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Jan. 25 – COMMENTARY: Parking Plan's impact on Workers? Full SaMMI Board Needs to Meet and Weigh in
Last Updated on Thursday, 25 January 2018 17:48	Lou Phelps	25 January 2018	Published on 25 January 2018	Hits: 6826
Category: Editorial & Opinion
By Lou Phelps, Publisher, Savannah Business Journal
January 25, 2018 – You see the 'DOT' free shuttles (pictured below) operating along the streets of Savannah's Historic District, but you may not realize how that system is funded.
And, in light of the City of Savannah's new parking plans that went into effect a few weeks ago - which reduced available spaces on certain blocks, extended hours when meters had to be fed, and increased per hour rates - new issues have arisen where the workers at the hotels, restaurants and bars that both locals and tourists frequent can't find places to park.
Further, they state they can't afford to park where they've always been parking, or are having to walk many blocks at 2:00 a.m. and 3:00 a.m. to get to their car in a distant city parking garage that offers more reasonable rates.
Critics believe the City rolled out its new 'Parking Matters' plan without taking into consideration this part of the impact of the new parking strategy, overseen by Sean Brandon.
The free DOT bus shuttle service is funded by money generated by, and overseen by, Savannah Area Mobility Inc., known as "SaMMI" to those in the tourism industry. It is a 501(c)6 non-profit organization that receives just over $1.4 million a year from a $1.00 "per occupied room" fee, called a 'POR.'
Founded in 2006, the purpose of SaMMI is to implement and oversee Savannah's Visitor Mobility Plan for an integrated mobility system, run by an eleven member board of directors that is made up of representatives of hospitality, tourism and municipal interests.
By contract, the City of Savannah's Revenue Dept. collects the money from all the hotels, distributes it to SaMMI, and that board then has responsibility for distributing the funds or signing contracts for transportation services.
One problem is, the board hasn't met since April 2016.
And, a new issue has arisen because City Manager Rob Hernandez notified the current chair of the Board, Jodi McIntyre, that he did not intend to renew the contract that ended Dec. 31. 2017, whereby the City agreed to collect the money and remit it to SaMMI.
The problem is: the $1.00 is a fee that the hotels agreed to charge themselves, back 12 years ago, in order to meet a need that city or county transportation planners were not addressing: moving those attending conventions between the city's hotels and over the bridge to the trade center on Hutchinson Island. The City Council passed an enabling Revenue Ordinance to back up the collection of the fee, but it was not a fee that prior City Council's imposed on the city's hotels.
It's important not to confuse these funds with the new $5.00 per room night that hotels now pay to the State of Georgia, as part of 2015 Statewide Transportation bill, HB 170, that added a flat $5.00 a night fee to all hotel's with more than five rooms, aimed at raising funds going to statewide transportation projects. Those funds are administered by the State.
When SaMMI was created, the initial 'POR' per occupied room started at $.35 cents a night onto the hotel bill, but then quickly was raised to $1.00 by the hotel stakeholders, the rate that has been used for over 10 years.
And, SaMMI began with the city's 13 largest hotels joining together who all voted amongst themselves to create a fund to pay for convention transportation due to the city's convention center being built across the river.
The money collected is divided between the DOT shuttle; the ferry system; and a Convention Transportation Fund that any convention group that meets certain criteria can apply to, to receive money to offset their needed buses and shuttles to get attendees from the Trade Center and between hotels.
The Westin pays $2.50 a night, more than double the POR of other hotels, because their guests need much more in the way of access to the city for restaurants and other entertainment venues. The CVB, under the leadership of Joe Marinelli, oversees approval and disbursement of the Convention Transportation Fund portion.
And, in the beginning, 10% of the money went to a fund to help fund festivals that would theoretically increase occupancy, to benefit all hotels, as the city was working to build its tourism numbers.
All of the city's hotels with over 25 rooms in what is termed the 'convention district' now participate in the SaMMI POR.
But, some of the hotel and tourism leaders interviewed, believe that, at its heart, it was and is a voluntary fee. The City's Revenue Ordinance simply created the legal vehicle for the City to collect. They point to the fact that the money is then given to SaMMI, which has the legal responsibility for its distribution.
The Bylaws of SaMMI spell out how the board is to be constituted, as well.
Several years ago, members of the SaMMI executive board – there is some level of disagreement on who approved what - voted that SaMMI would partner with Chatham Area Transit on services, even though "our visitors don't use CAT services, and never really have," says one of Savannah's top tourism leaders.
And, there have been 'issues' with the DOT shuttle, which some believe "has a clientele, including a lot of homeless riders, that turned off tourists," states another.
There are those who argue,also, that it's really the city and the county's responsibility to build a public transportation system that insures employees can get to work – not the job of the tourism industry – particularly when the city approves building permits and issues business licenses, and is glad to tax the heck out of everyone, but doesn't have a plan for where employees are supposed to park.
Hernandez and the City Council can decide to end their contract with SaMMI, but they also risk that hotels will be unwilling to charge the POR of $1.00 that is helping support the tourism jobs, property taxes and sales tax dollars that fund the city government.
The current SaMMI board members are: Jody McIntyre, Chair, Director of Sales and Marketing, Savannah Marriott Riverfront; Robert Coffey, Consultant, Savannah International Trade & Convention Center; Charlie Brazil, General Manager, Old Town Trolley Tours; Chris Crane, Vice Chair,General Manager at Embassy Suites Savannah; Mark Dana, Vice President, Prince Bush Smith Hotels; Marc Friday, Immediate Past Chair, General Manager, Planters Inn; Bill Hubbard, President & CEO, Savannah Area Chamber of Commerce; Joe Marinelli, President, Visit Savannah; Kellie Linder, Secretary-Treasurer, General Manager, Hotel Indigo; Veleeta McDonald; Director of Parking and Mobility Services, City of Savannah; Curtis Koleber, Chief Executive Office.
The City is apparently retaining the money, cutting out the SaMMI board process, and ignoring the history of cooperative efforts by the city's hotels to address needed transportation problems.
It's clear that before this issue goes any further, and the City keeps operating in a vacuum about the needs of ALL downtown businesses and their employees trying to get to work, the SaMMI Board needs to meet, adhere to its Bylaws, decide on their future, and issue a full report to all its member hotels.


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Contract Program Security Officer
Advantage SCI Reston, VA, USA
Position: Contract Program Security Officer
Reports To: The Customer and Program Manager
Clearance Type: Active TS/SCI with CI Poly
Work Location: Reston, VA
Advantage SCI is seeking Contract Program Security Officer to be considered for employment. Individual will provide support to the government Program Security Officer (PSO). CPSO's are responsible for program security and execution of all security policies and requirements for specified Special Access Programs (SAPs), compartments, sub-compartments, and projects. CPSOs must review, verify, edit, draft, and submit security paperwork to accredit facilities and automated information systems (AIS) in accordance with applicable policies. They will conduct or support the periodic security inspections of cleared facilities to ensure compliance with the Technical Specifications for Construction and Management of SAP Sensitive Compartmented Information Facilities, National Industrial Security Programs Operating Manual (NISPOM), the NISPOM supplemental, and-any unique requirements of various classified programs. Travel within the United States (CONUS plus Alaska and Hawaii, but not the U.S. Territory) to conduct or support facility inspections. Draft and maintain standard operating procedures (SOP), Security Classification Guides (SCGs) and other essential security documents, records. Implement a security education program for assigned personnel tailored to supported programs.
Bachelor's degree or equivalent experience.
5 years specialized experience with government security databases (e.g., JADE, Scattered Castles, JPAS).
Training and experience working with SAPs.
Completion of the instructor led Center for Development of Security Excellence (CDSE) Introduction to SAPSs course; experience implementing security training to meet specific SAP requirements; experience performing PSO functions in support of both government and contractor customers.
Completion of CDSE Orientation to SAP Security Compliance Inspections course.
Experience with SCIF Accreditations and Inspections.
Possess a TS/SCI and successfully passing CI Poly.
Knowledge of the Microsoft Office Suite, particularly Outlook, Word, and Excel.
Excellent written and oral reporting skills, interpersonal skills, and the ability to communicate at all levels of the organization and customers across geographically dispersed sites.
Experience working in DIA a plus.
Must have a valid certification of completion in PII and Cyber Awareness Challenge from Information Assurance Support Environment (Only valid within 30 days of hire). To obtain the certification, visit http://iase.disa.mil/eta/.
Able to sit and work at a computer keyboard for extended periods of time
Able to stoop, kneel, bend at the waist and reach daily
Able to lift up to 35 pounds occasionally.
Noise level: Low to moderate
Advantage SCI, LLC is an Equal Opportunity Employer
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Posted date: 14 days ago
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text:
Donate FAQ's
What is the cost of a meal?
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Nutri-eSCREEN
Breakfast Form
Our Management Staff and Committee
Catering & Fundraising
A bequest is a gift or legacy left in a Will. Bequests are a tangible way of ensuring continuance of quality care for people with a variety of support needs, thus enabling them to reside for as long as possible where they are happiest – in their own home.
If you do choose to provide a bequest your generous donation will go towards assisting the Association to continue to fulfill its mission of supporting the Meals on Wheels Member Services in their provision of meals to those in need.
If you are considering a bequest to the Meals on Wheels Pine Rivers and District Inc. please consult with your Solicitor to arrange a suitable clause to be included in your Will.
The Association has developed a standard bequest form, which may be useful when planning and arranging your bequest.
 Make your Bequest Now.
If you wish to make a donation or bequest to your local Service Provider please contact them directly for advice.
Donations and Bequests can be given to:
the State Association for the wider work of Meals on Wheels; OR
to the Local Service operating in a specific area.
Donations of $2.00 and over are tax deductible. If you require a receipt please email us at admin@mowpr.org to let us know you have made a donation to the GIFT FUND and require a receipt.
The Form of Bequest is a Policy document of Queensland Meals on Wheels Services Association Inc.
Meals on Wheels Pine Rivers and District was founded 38 years ago and has been operating from the same premises at Hyland House 3 Mundin St Petrie Qld. We are an Incorporated Association operating as a Registered Charity. read more...
Meals on Wheels Pine Rivers and District has operated from Mundin St, Petrie since 1976. We are an Incorporated Association and Registered Charity. read more...
We are located at Hyland House,
3 Mundin Street Petrie Qld 4502
07 3285 2532
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Meals on Wheels Services Pine Rivers and District is supported by funding from the Australian Government and other government sources.
The material contained herein this website does not necessarily represent the views or policies of the Australian Government, local government or agencies.
Meals on Wheels Pine Rivers and District 07 3285 2532 admin@mowpr.org


Wanda Tima-Gilles, president of L'Union Suite, the popular Haitian-American social platform, and two other organizers initially had planned a simpler welcome for Miss Haiti, Raquel Pelissier.
But on Thursday night, scores of Haitians, including celebrity DJ Michael Brun, turned up at the invitation-only event to honor Pelissier, who was named runner-up behind Miss France Iris Mittenaere in the Miss Universe pageant.
Written by Jacqueline Charles and originally published at Miami.com.


.: Sheila Kealey :: Ski XCOttawa.ca :: Skiing in Ottawa and Gatineau Park :.
Cooking and baking . . . I love creating new recipes!
Hill repeats - any hill really, but Gatineau Park's Penguin hill or the climb from P12 are the longest and most scenic!


most varied of contexts and disciplines selected over 200 works from 100 years of international radio art for »Radiophonic Spaces« and arranged them in 13 ›narratives‹. The result is a kaleidoscopic overview of the development of radio art as well as of recurring themes, motifs and procedures.
The listening discovery course allows works of radio art to be heard that are often, otherwise difficult to access and to relate these to different contexts. »Radiophonic Spaces« is an experimental archive that does not claim to be either complete or self-contained. Rather, it is an invitation to the public to playfully reflect on the design and structure of the radiophonic space. An immersive headphone system enables visitors to quite literally submerse themselves in radio art and to listen their way through the collection.


Enjoy reading and share 56 famous quotes about Take One Step At A Time with everyone.
"All of this, you and me, is brand new, you're right. Let's just take this one small step at a time."
"Before I love you can come out of my mouth again, the front door swings open and Julia walks outside. "We're going to have to set some ground rules," she says. There's more amusement in her voice than anger or annoyance.
"Sorry, Julia," I yell over my shoulder. I turn back to Lake and kiss her one last time, then take a step away from her. "It's just that I'm madly in love with your daughter!"
Want to see more pictures of Take One Step At A Time quotes? Click on image of Take One Step At A Time quotes to view full size.


1.Can meet your require at any time.
2.OEM Accepted : as your design produce .
3.Good Quality :We have strict quality control system.
4.We offer competitive price and guaranteed quality.
5. High efficiency,considerate service,We are reliable exporter, you are always welcome!


text:
package ninja.leaping.permissionsex;

import com.google.common.collect.ImmutableSet;
import ninja.leaping.permissionsex.util.command.CommandSpec;
import org.slf4j.Logger;
import org.slf4j.LoggerFactory;

import javax.sql.DataSource;
import java.io.File;
import java.util.Set;
import java.util.concurrent.Executor;

public class TestImplementationInterface implements ImplementationInterface {
    private final File baseDirectory;
    private final Logger logger = LoggerFactory.getLogger("TestImpl");

    public TestImplementationInterface(File baseDirectory) {
        this.baseDirectory = baseDirectory;
    }

    @Override
    public File getBaseDirectory() {
        return baseDirectory;
    }

    @Override
    public Logger getLogger() {
        return logger;
    }

    @Override
    public DataSource getDataSourceForURL(String url) {
        return null;
    }

    /**
     * Get an executor to run tasks asynchronously on.
     *
     * @return The async executor
     */
    @Override
    public Executor getAsyncExecutor() {
        return Runnable::run;
    }

    @Override
    public void registerCommand(CommandSpec command) {
    }

    @Override
    public Set<CommandSpec> getImplementationCommands() {
        return ImmutableSet.of();
    }

    @Override
    public String getVersion() {
        return "test";
    }
}

redpajama_set_name: RedPajamaGithub


Hot pepper (Capsicum annuum) is one of the most consumed vegetable crops in the world and useful to human as it has many nutritional and medicinal values. Genomic resources of pepper are publically available since the pepper genomes have been completed and massive data such as transcriptomes have been deposited. Nevertheless, global transcriptome profiling is needed to identify molecular mechanisms related to agronomic traits in pepper, but limited analyses are published. Here, we report the comprehensive analysis of pepper transcriptomes during fruit ripening and pathogen infection. For the ripening, transcriptome data were obtained from placenta and pericarp at seven developmental stages. To reveal global transcriptomic landscapes during infection, leaves at six time points post-infection by one of three pathogens (Phytophthora infestans, Pepper mottle virus, and Tobacco mosaic virus P0 strain) were profiled. The massive parallel transcriptome profiling in this study will serve as a valuable resource for detection of molecular networks of fruit development and disease resistance in Capsicum annuum.
Large amounts of transcriptome data have been released using next-generation sequencing technology for past decades, which enables us to study organisms in a genomic perspective. In plants, global gene expression profiling was performed to elucidate molecular mechanisms for organ specificity, developmental changes, and disease resistance1,2,3,4,5,6,7,8,9,10. For example, the transcriptome analysis on developing seeds suggested that transcriptional change in endosperm and embryo was regulated by distinct co-expressed networks in wheat and maize1,2. In addition, the expression analysis of pathogen infected leaves in Arabidopsis and tomato revealed that a number of genes and networks interacted with each other in a specific time and a stage7,8,9,10. A recent study using multiple transcriptomes identified the vacuolar protease SLVPE3 and their target, serine protease inhibitor KTI4, involved in fruit ripening and disease resistance11. These genomic and transcriptomic studies have allowed us to unveil gene expression mechanisms and find target genes associated with agronomic traits.
Hot peppers (Capsicum spp.), belonging to Solanaceae family, are the most widely cultivated spice in the world. In 2013, the worldwide production of pepper was 31.1 million tons (14.6 billion US dollars), which was the third largest among vegetable crops12. The pepper fruits are rich sources of vitamin C, pigments, minerals and pungent agents that are known as nutritional and functional properties for human health13. The genus Capsicum consists of 33 undomesticated and five domesticated species including the most widely cultivated species, Capsicum annuum14. Various genetic studies for the pepper have been performed to unveil molecular mechanisms of important agronomic traits and disease resistance15,16,17,18,19,20,21,22,23,24. Recently, completion of the multiple reference pepper genomes with the deposited large amount of transcriptome data has enabled to perform in-depth analyses for these agronomical traits13,25,26,27,28. However, comprehensive transcriptome analyses to identify expression and expressional variations of genes using the large transcriptome resources of the peppers are still lacking.
In this study, we openly released the hot pepper transcriptomes that were previously published13,21,23. We described in detail the expression profiling methods of samples from fruit development, pathogen infection in each time point and tissues in C. annuum (Fig. 1). Total 125.68 Gb of transcriptome data from previously reported fruit tissues (pericarp and placenta) and infected leaves with P. infestans, Pepper mottle virus (PepMov), and Tobacco mosaic virus (TMV) P0 strain was generated (Table 1 and Data Citation 1: figshare https://doi.org/10.6084/m9.figshare.c.4070300). After preprocessing analyses, we mapped the remaining sequences to the reference pepper genome (Data Citation 1: figshare https://doi.org/10.6084/m9.figshare.c.4070300). The preprocessed sequences were validated through quality assessment (Fig. 2). A principal component analysis (PCA) showed the global gene expression patterns and variations between samples (Fig. 3). Consequently, the expression profiling of multiple conditions in pepper will provide valuable resources for analysis on fruit development, ripening and disease resistance.
Figure 1: Schematic overview of the analysis pipeline.
The pepper transcriptome of fruit organs and pathogen- infected leaves including three biological replicates except for Mock-Up (n=2) were collected from NCBI SRA (SRP106410 and SRP119199). All raw sequences were pre-processed and assessed using FastQC (http://www.bioinformatics.babraham.ac.uk/projects/fastqc) and MultiQC. The filtered reads were mapped to Capsicum annuum reference genome (v.1.55) using CLC assembly. The mapped reads were normalized RPKM and log2 transformed mean value were used to PCA.
Table 1: Statistics of pepper transcriptomes used in this study.
Figure 2: Quality assessment of pepper transcriptomes.
The filtered reads from all 136 samples were assessed by MultiQC. (a) Mean quality scores distribution in each position. (b) Read counts distribution for mean sequence quality. (c) GC ratio distribution. (d) Read length distribution.
Figure 3: Global gene expression pattern in pepper transcriptomes.
The log2 transformed mean RPKM values were plotted by boxplot function in R (a). The line plot (b) and scatter plots of PC1 versus PC2 (c) and PC1 versus PC3 (d) were drawn using previously published code with modification32. The abbreviations see method section 2.
Massive transcriptome data for seven developmental stages in fruit (fruit development set) and six to seven time points in leaves infected by pathogens (pathogen infection set) were generated to decipher global gene expression profiling for fruit development and disease resistance in C. annuum. The reference pepper genome annotation v1.55 was used (http://peppergenome.snu.ac.kr). Reference mapping and normalization for filtered transcriptome were performed after quality filtering and assessment. A principal component analysis (PCA) was performed to elucidate global gene expression patterns and evaluate the correlation between samples using log2 transformed RPKM values (Fig. 1).
The transcriptome data in this study were acquired from CM334 dataset (Data Citation 2: NCBI Sequence Read Archive SRP119199 and Data Citation 3: NCBI Sequence Read Archive SRP106410). For transcriptome profiling of fruit development, pepper fruits at seven ripening stages were harvested at 6, 16, 25, 36, 38, 43, and 48 days post-anthesis (DPA) as previously described13. For transcriptome profiling of immune response to multiple pathogens, pepper leaves were inoculated with 15 μl droplets of 5×104 zoospores ml−1 suspension in P. infestans, and PepMov and TMV P0 strain purified from systemically infected tobacco leaves as previously described21,23. Inoculated leaves harvested at several time points from three biological replicates were ground in liquid nitrogen, which was used for total RNA purification. The strand-specific libraries with 150–200 bp insert size were constructed and sequenced with Illumina HiSeq 2000 and 2500 platforms (Illumina Inc., San Diego, USA) using fruit development set and pathogen infection set, respectively. Sample names were assigned: placenta (PL); pericarp (PR); stage 1, 6 DPA (1); stage 2, 16 DPA (2); stage 3, 25 DPA (3); mature green, 36 DPA (MG); breaker, 38 DPA (B); breaker plus 5, 43 DPA (B5); and breaker plus 10, 48 DPA (B10); control for P. infestans (TDW) and virus (Mock); infection for P. infestans (Pi), pepper mottle virus (PepMov), TMV P0 strain (TMV). Only single (forward) reads were used in pathogen infection set to reduce the read type variable for the fruit development set.
The raw sequences of transcriptome were filtered and trimmed using previously described methods to remove contaminated and low quality reads13. The raw reads containing reference bacterial sequences were filtered using Bowtie2 v2.0.0-beta7 with modified parameters (--local –D 15 –R 2 –N 0 –L 20 –I S,1,0.65)29. The sequences with quality scores below 20 were trimmed using the CLC quality trimming software (CLC bio, Aarhus, Denmark). Minimum length cut-off for 50 bp and 101 bp read was 35 bp and 71 bp, respectively. The reads were validated using FastQC v0.11.5 (ref. 30) and MultiQC v1.3.dev0 (ref. 31) software with default parameters. The processed reads were mapped to the v.1.55 pepper CDS using CLC assembly cell with –s 0.99 –l 0.9 parameters (CLC bio, Aarhus, Denmark). Total mapped reads were normalized to reads per kilobase per million mapped reads (RPKM).
Average RPKM values for each time point and tissue were used for PCA. To reduce the influence of extremely expressed genes, RPKM values were log2-transformed and boxplot was drawn using boxplot function in R. PCA was performed using previously published code with modification32.
The detailed transcriptome information and average RPKM values for all pepper samples were deposited in figshare (Data Citation 1: figshare https://doi.org/10.6084/m9.figshare.c.4070300). The raw reads for transcriptome were deposited in NCBI Sequence Read Archive (SRA) accession (Data Citation 2: NCBI Sequence Read Archive SRP119199 and Data Citation 3: NCBI Sequence Read Archive SRP106410).
To assess total data quality, we performed the quality check using FastQC and MultiQC software for all preprocessed samples. Overall, the mean quality scores in each base position were higher than 27 (Fig. 2a). The read counts per quality scores were distributed above 25 and average quality was higher than 35 (Fig. 2b). The normal distribution of GC content was indicating non-contaminated in sequencing process (Fig. 2c). The average sequence lengths were 50 bp and 99 bp for fruit development set and pathogen infection set, respectively (Fig. 2d). These numerical values represent that high-quality sequences were obtained for further analysis.
To elucidate global gene expression patterns in multiple conditions, filtered reads were mapped to pepper CDS and normalized by RPKM. The average RPKM values of three biological replicates in each sample were used for further analysis. A principal component analysis using log2 transformed RPKM showed that first three PCs explained most of the variance (Fig. 3a,b). The comparisons between PC1 and PC2 or PC3 indicated that the group of fruit organs and leaves infected by pathogen were separated clearly. In addition, the leaves infected by P. infestans and group of virus (PepMov and TMV P0 strain) showed a different pattern with minor overlap. (Fig. 3c,d).
How to cite this article: Kim M.-S. et al. Global gene expression profiling for fruit organs and pathogen infections in the pepper, Capsicum annuum L. 5:180103 doi: 10.1038/sdata.2018.103 (2018).
Lu, X. D. et al. The differential transcription network between embryo and endosperm in the early developing maize seed . Plant Physiol. 162, 440–455 (2013).
Pfeifer, M. et al. Genome interplay in the grain transcriptome of hexaploid bread wheat . Science 345, 1250091 (2014).
Digel, B., Pankin, A. & von Korff, M. Global transcriptome profiling of developing leaf and shoot apices reveals distinct genetic and environmental control of floral transition and inflorescence development in barley . Plant Cell 27, 2318–2334 (2015).
Han, Y. et al. Comparative RNA-seq analysis of transcriptome dynamics during petal development in Rosa chinensis . Sci. Rep 7, 43382 (2017).
Kang, C. Y. et al. Genome-scale transcriptomic insights into early-stage fruit development in woodland strawberry Fragaria vesca . Plant Cell 25, 1960–1978 (2013).
Li, J. Y. et al. Comprehensive RNA-Seq analysis on the regulation of tomato ripening by exogenous auxin . PLoS ONE 11, e0156453 (2016).
Jupe, J. et al. Phytophthora capsici-tomato interaction features dramatic shifts in gene expression associated with a hemi-biotrophic lifestyle . Genome Biol. 14, R63 (2013).
Lewis, L. A. et al. Transcriptional dynamics driving MAMP-triggered immunity and pathogen effector-mediated immunosuppression in Arabidopsis leaves following infection with Pseudomonas syringae pv. tomato DC3000 . Plant Cell 27, 3038–3064 (2015).
Pombo, M. A. et al. Transcriptomic analysis reveals tomato genes whose expression is induced specifically during effector-triggered immunity and identifies the Epk1 protein kinase which is required for the host response to three bacterial effector proteins . Genome Biol. 15, 492 (2014).
Windram, O. et al. Arabidopsis defense against Botrytis cinerea: chronology and regulation deciphered by high-resolution temporal transcriptomic analysis . Plant Cell 24, 3530–3557 (2012).
Wang, W., Cai, J., Wang, P., Tian, S. & Qin, G. Post-transcriptional regulation of fruit ripening and disease resistance in tomato by the vacuolar protease SlVPE3 . Genome Biol. 18, 47 (2017).
Food and Agriculture Organization of the United Nations. FAO statistics http://faostat.fao.org/ (2013).
Kim, S. et al. Genome sequence of the hot pepper provides insights into the evolution of pungency in Capsicum species . Nat. Genet. 46, 270–278 (2014).
van Zonneveld, M. et al. Screening genetic resources of Capsicum peppers in their primary center of diversity in Bolivia and Peru . PLoS ONE 10, e0134663 (2015).
Ramchiary, N., Kehie, M., Brahma, V., Kumaria, S. & Tandon, P. Application of genetics and genomics towards Capsicum translational research . Plant Biotechnol. Rep. 8, 101–123 (2014).
Caranta, C. et al. A complementation of two genes originating from susceptible Capsicum annuum lines confers a new and complete resistance to pepper veinal mottle virus . Phytopathology 86, 739–743 (1996).
Caranta, C., Thabuis, A. & Palloix, A. Development of a CAPS marker for the Pvr4 locus: a tool for pyramiding potyvirus resistance genes in pepper . Genome 42, 1111–1116 (1999).
Grube, R. C., Blauth, J. R., Arnedo, M. S., Caranta, C. & Jahn, M. K. Identification and comparative mapping of a dominant potyvirus resistance gene cluster in Capsicum . Theor. Appl. Genet. 101, 852–859 (2000).
Huh, S. U. et al. Capsicum annuum transcription factor WRKYa positively regulates defense response upon TMV infection and is a substrate of CaMK1 and CaMK2 . Sci. Rep 5, 7981 (2015).
Tran, P. T., Choi, H., Choi, D. & Kim, K. H. Virus-induced gene silencing reveals signal transduction components required for the Pvr9-mediated hypersensitive response in Nicotiana benthamiana . Virology 495, 167–172 (2016).
Kang, W. H., Kim, S., Lee, H. A., Choi, D. & Yeom, S. I. Genome-wide analysis of Dof transcription factors reveals functional characteristics during development and response to biotic stresses in pepper . Sci. Rep 6, 33332 (2016).
Lee, H. A. et al. Multiple recognition of RXLR effectors is associated with nonhost resistance of pepper against Phytophthora infestans . New Phytol. 203, 926–938 (2014).
Lee, H. A., Kim, S., Kim, S. & Choi, D. Expansion of sesquiterpene biosynthetic gene clusters in pepper confers nonhost resistance to the Irish potato famine pathogen . New Phytol. 215, 1132–1143 (2017).
Kim, S. B. et al. Divergent evolution of multiple virus-resistance genes from a progenitor in Capsicum spp . New Phytol. 213, 886–899 (2017).
Kim, H. J. et al. Pepper EST database: comprehensive in silico tool for analyzing the chili pepper (Capsicum annuum) transcriptome . BMC Plant Biol. 8, 101 (2008).
Liu, F. et al. PepperHub, an informatics hub for the chili pepper research community . Mol. Plant 10, 1129–1132 (2017).
Qin, C. et al. Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization . Proc. Natl. Acad. Sci. U.S.A. 111, 5135–5140 (2014).
Kim, S. et al. New reference genome sequences of hot pepper reveal the massive evolution of plant disease-resistance genes by retroduplication . Genome Biol. 18, 210 (2017).
Andrews, S. FastQC: a quality control tool for high throughput sequence data. Available online at http://www.bioinformatics.babraham.ac.uk/projects/fastqc (2010).
Ewels, P., Magnusson, M., Lundin, S. & Kaller, M. MultiQC: summarize analysis results for multiple tools and samples in a single report . Bioinformatics 32, 3047–3048 (2016).
Söllner, J. F. et al. An RNA-Seq atlas of gene expression in mouse and rat normal tissues . Scientific Data 4, 170185 (2017).
This work was supported by a grant from the Agricultural Genome Center of the Next Generation Biogreen 21 Program of RDA (Project No. PJ01127501).
D.C. conceived the project, designed the content, and organized the manuscript. M.-S.K. performed data collection, analysis, and wrote the manuscript. E.S., S.-I.Y., S.-B.K., and H.-A.L. generated the transcriptome data. S.K., J.J., K.-T.K., H.-A.L., H.-Y.L., J.P., Y.-H.L. and D.C. wrote the manuscript.


text:
At Your Own Risk is the second studio album by American West Coast hip hop artist King Tee. It was released on September 24, 1990 via Capitol Records. Production was handled by several record producers, including DJ Pooh, E-Swift, Bilal Bashir, Bronick Wrobleski, J.R. Coes, DJ Aladdin, and King T himself. It also features guest appearances provided by Ice Cube and Breeze on the album's final track "Played Like a Piano". The album spawned four singles: "Ruff Rhyme (Back Again)", "Diss You", "At Your Own Risk" and "Played Like a Piano", which were later included on the rapper's greatest hits album titled Ruff Rhymes: Greatest Hits Collection.

The album peaked at number 175 on the US Billboard 200 and number 35 on the Top R&B/Hip-Hop Albums. Its single "Ruff Rhyme (Back Again)" peaked at number 18 on the Hot Rap Songs.

Track listing

Personnel
 Roger McBride – main artist, producer (tracks: 1, 2, 13), mixing (tracks: 1, 2, 8, 10)
 O'Shea Jackson – featured artist (track 14)
 M.C. Breeze – featured artist (track 14)
 Mark S. Jordan – producer (tracks: 2, 3, 5-7, 9-14), co-producer (track 4), mixing (tracks: 3-7, 9-14)
 Bilal Bashir – producer (tracks: 1, 8)
 J.R. Coes – producer (track 4), co-producer (track 7)
 Bronek Wroblewski – producer (track 4)
 Eric Brooks – producer (track 11)
 Bob Morse – engineering (tracks: 1, 3-7, 9-14)
 Vachik Aghaniantz – engineering (tracks: 2, 8)
 Alphonso Henderson – mixing (track 10)
 Glen E. Friedman – photography
 Jorge Hinojosa – management
 Eric Greenspan – management

Album singles

Chart positions
Album

Singles

References

External links

1990 albums
King Tee albums
Capitol Records albums
Albums produced by DJ Pooh
Albums produced by DJ Aladdin

redpajama_set_name: RedPajamaWikipedia


text:
Relativity makes bid for Maker Studios worth up to $1.1B
The offer is a last-minute effort to thwart the Disney acquisition deal that is scheduled to be voted on tomorrow.
By Melita Kuburas
UPDATED AT 17:48 EST: Later on Monday Maker Studios announced shareholders approved the merger with Disney.
Relativity Media is trying to sweep up Maker Studios away from Disney with a last-minute bid worth up to $1.1 billion.
Relativity amended the deal Monday morning after initially offering $500 million plus $400 million if financial targets are met, and an additional $100 million in bonuses for key YouTube talent and execs.
A source familiar with the deal says the new offer, made at about 7:30 a.m. PST, is now $525 million in cash and stock, plus a potential $500 million in cash and stock if certain financial targets are met. Relativity is still sweetening the deal with an additional $75 million bonus pool that would be available to YouTube talent within Maker's network as well as key Maker executives. The bonus offer (in stocks) is guaranteed, not contingent on performance targets, the source confirms. It's meant for people who have been critical to the success of the company, but aren't existing stockholders.
"Relativity's proposal fully values Maker Studios while providing its shareholders far more upside potential for growth than the Disney offer. Our offer also includes a substantial opportunity for Maker's talent and employees to directly and significantly participate in the long-term growth of Relativity should the transaction be completed," the company says in a statement.
"Relativity and Maker Studios are natural partners. We both share a commitment to challenging the status quo, breaking down old models that don't work and inventing new ones that do. We are confident the Maker Studios board and its shareholders will recognize the full value of the Relativity offer."
Barclays and Jefferies are Relativity's bankers on the deal. Relativity is the company behind movies like The Social Network, Safe Haven and Act of Valor.
Last week, former Maker CEO Danny Zappin and three other co-founders filed a lawsuit in an attempt to thwart the Disney sale.
Danny Zappin, Disney, Maker Studios, Relativity Media
Melita Kuburas is the editor of StreamDaily. You can reach her directly at press[at]streamdaily.tv or on Twitter @melitakuburas
Sale approved: Maker goes to Mouse
Maker Studios signs Lindsey Stirling
ITV invests into Zealot, touting digital studio potential
Maker Studios: Ynon Kreiz out, Courtney Holt in


text:
Articles Posted in EAD
Immigration Updates: TPS Extensions for Haitians and USCIS Commitments to Immigration in the New Year 2023
We close off the week with some new announcements from the United States Citizenship and Immigration Services (USCIS) regarding TPS extensions for Haitian nationals, and USCIS commitments to improve immigration in the new year – fiscal year 2023.
TPS Extended for Haitian Nationals
On December 5, 2022, the Secretary of Homeland Security, Alejandro N. Mayorkas, announced that the TPS designation for Haiti will be automatically extended for 18 additional months. Haitian nationals with TPS benefits will have the opportunity to re-register for an extension of their TPS benefits for a period of 18 months from February 4, 2023, through August 3, 2024.
This automatic extension has been granted because the Secretary has determined that conditions continue to exist to support Haiti's TPS designation due to extraordinary and temporary conditions in the country including a prolonged political crisis, insecurity, gang violence, and catastrophic earthquakes. According to Secretary Mayorkas, "The conditions in Haiti, including socioeconomic challenges, political instability, and gang violence and crime – aggravated by environmental disaster – compelled the humanitarian relief we are providing today."
As a reminder, Haitians entering the United States after November 6, 2022, are not eligible for TPS benefits and, will be subject to removal from the United States if they have no legal basis to remain in the country.
TPS will apply only to those individuals who have already been residing in the United States as of November 6, 2022, and who meet all other requirements to receive the TPS extension. Those who attempt to travel to the United States after November 6, 2022, are NOT eligible for TPS benefits.
Soon, the Department of Homeland Security will publish a notice in the Federal Register explaining the eligibility criteria and procedures to re-register for TPS, renew Employment Authorization Documents (EADs), and submission of initial TPS application under the re-designation.
Posted in: Adjustment of Status, Biden administration, DHS, EAD, EAD Renewal, Employment Authorization Document, Employment Based Petitions, Employment-Based Categories, Family Visas, Federal Register, First Time Clients, Free Consultation, Global Immigration, Haiti, Immediate Relatives, Immigrant Visas, News, Temporary Protected Status, TPS, TPS Re-Registration, USCIS, USCIS Backlogs, USCIS Field Offices, USCIS Lockboxes, USCIS Service Centers, Visa Backlogs and Work Visas
Updated: December 8, 2022 6:49 pm
USCIS Announces Accrediting Council for Independent Colleges and Schools (ACICS) Loses Accreditation: How this Impacts F-1 Students, STEM OPT Extensions, H-1B Master's Cap, and More…
In this blog post, we bring you some unfortunate news. Recently, the U.S. Department of Education announced that it will no longer recognize the Accrediting Council for Independent Colleges and Schools (ACICS) as an accrediting agency.
Sadly, this means that certain F-1 student visa applicants will be impacted by this change, including those undertaking an English language study program. The U.S. Citizenship and Immigration Services has said that such programs are required to be accredited under the Accreditation of English Language Training Programs Act.
Additionally, this change will impact F-1 students applying for a 24-month science, technology, engineering and mathematics (STEM) optional practical training (OPT) extension, because government regulations now require use of a degree from an accredited, Student and Exchange Visitor Program (SEVP) certified school to receive a STEM OPT extension.
The regulations make clear that the school must be accredited at the time of the application (the date of the designated school official's (DSO) recommendation on the Form I-20, Certificate of Eligibility for Nonimmigrant Student Status).
Students who have been impacted by this change will receive notification letters from SEVP informing them that their schools' certification has been withdrawn.
USCIS has said that students who are enrolled at an ACICS-accredited school should contact their DSOs immediately to understand how this loss of accreditation will impact their status and/or immigration benefits.
To make matters worse, schools accredited by ACICS will not be able to issue program extensions, and students will only be allowed to finish their current session if the ACICS-accredited school chooses to voluntarily withdraw its certification or if is withdrawn by SEVP.
If a student's ACICS-accredited school can provide evidence of a Department of Education recognized accrediting agency or evidence in lieu of accreditation within the allotted timeframe, the student may remain at the school to complete their program of study.
Requests for Evidence Imminent for I-539 Extend/Change of Status
The U.S. Citizenship and Immigration Services (USCIS) will be issuing requests for evidence (RFEs) to individuals who filed Form I-539, Application to Extend/Change Nonimmigrant Status, on or after August 19, 2022, requesting a change of status or reinstatement to attend an ACICS-accredited English language study program.
Once the individual receives the RFE, they will be given the opportunity to provide evidence in response, such as documentation showing that the English language study program they are seeking to enroll in meets the accreditation requirements.
If the student does not submit a new Form I-20 from a school accredited by an entity recognized by the Department of Education, USCIS will deny a change of status or reinstatement request.
Posted in: Biden administration, DSO, EAD, EAD Renewal, Employment Authorization Document, English Language Study, F-1 Visa, First Time Clients, Free Consultation, Global Immigration, H-1B Lottery, H1B Employers, H1B FY 2023, H1B Visas, Highly Skilled Workers, I-140, I-20, I-539 Change of Status, I-765, International Students, News, NOID, NOIDs, Nonimmigrant Visas, OPT, Optional Practical Training, Policies, Policy, Request for Evidence, RFE Deadlines, RFEs, SEVIS, SEVP, Specialty Occupations, STEM, STEM OPT, Student Visa, Student Visas, Temporary Visas, USCIS and Work permits
Updated: November 4, 2022 7:25 pm
DHS Announces Ethiopia Designation for Temporary Protected Status for 18 Months
Happy Halloween! In this blog post, we bring you a brand-new immigration update.
On October 21, 2022, the Department of Homeland Security (DHS) announced the designation of Ethiopia for Temporary Protected Status (TPS) for a period of 18 months. This decision marks Ethiopia's first designation for TPS.
This designation was made based on ongoing armed conflict and extraordinary and temporary conditions in Ethiopia that prevent its nationals from safely returning to their country. Concerns relating to conflict-related violence including killings, rape, and gender-based violence prompted the Secretary of Homeland Security to make this decision. Other temporary conditions further complicate the return of Ethiopian nationals including flooding, drought, and disease outbreaks.
In response to the DHS announcement, Secretary of Homeland Security Alejandro N. Mayorkas explained, "Ethiopian nationals currently residing in the U.S. who cannot safely return due to conflict-related violence and a humanitarian crisis involving severe food shortages, flooding, drought, and displacement, will be able to remain and work in the United States until conditions in their home country improve."
Posted in: Biden administration, Deportations, Detention, Detentions, DHS, EAD, Employment Authorization Document, First Time Clients, Free Consultation, Global Immigration, I-765, News, Temporary Protected Status, TPS, USCIS, USCIS Backlogs and Work permits
Updated: October 31, 2022 10:27 pm
Biden administration extends TPS protections for Venezuelan Nationals, Re-Registration Period Opens
Welcome back to Visalawyerblog! We hope you had a wonderful weekend.
In this blog post, we share with you some exciting news for Venezuelan nationals receiving benefits under the Temporary Protected Status (TPS) program.
The Biden administration has made the decision to extend Temporary Protected Status for Venezuelan nationals currently receiving protections under the program until March 10, 2024. In addition, the re-designation means that certain eligible Venezuelan nationals will be able to apply for TPS protections for the first time.
Extension of Designation of Venezuela for TPS
On July 11, 2022, the Secretary of Homeland Security, Alejandro Mayorkas, announced an 18-month extension and redesignation of Temporary Protected Status (TPS) for the country of Venezuela. This extension and re-designation will be in effect from September 10, 2022, through March 10, 2024 (an 18-month period).
Secretary Mayorkas made this decision after consulting with government officials and taking into consideration the ongoing conflict in Venezuela, lack of access to food, water, healthcare, and other conditions.
Mayorkas found that these circumstances ultimately prevented Venezuelan nationals from safely returning to their home country stating, "After careful consideration, and in consultation with the Secretary of State, today I am extending that designation. This action is one of many ways the Biden administration is providing humanitarian support to Venezuelans at home and abroad, together with our regional partners. We will continue to work with our international partners to address the challenges of regional migration while ensuring our borders remain secure."
Currently, there are an estimated 343,000 individuals potentially eligible for TPS under the existing designation of Venezuela. The program's extension will mean that these beneficiaries can re-register for benefits and retain TPS status through March 10, 2024, so long as they can demonstrate that they continue to meet the TPS eligibility requirements.
Posted in: Biden administration, EAD, EAD Renewal, Employment Authorization Document, Federal Register, First Time Clients, Free Consultation, Global Immigration, I-131, I-765, I-821, News, Policies, TPS, TPS Re-Registration, USCIS, Venezuela and Work permits
DHS hosting upcoming webinar for nationals of Cameroon interested in applying for Temporary Protected Status: September 8, 2022
Are you a national of Cameroon interested in applying for Temporary Protected Status (TPS)?
Then you may be interested to know that the U.S. Citizenship and Immigration Services (USCIS) will be hosting a webinar on Thursday September 8, 2022, from 2 to 3 pm Eastern Time all about the application criteria. As previously reported, beginning April 15, 2022, DHS designated Cameroon for TPS benefits for a period of 18 months. The registration period is set to close on December 7, 2023.
Individuals eligible for TPS under Cameroon's designation must have continuously resided in the United States since April 14, 2022 and demonstrate continuous physical presence in the United States since June 7, 2022.
Any nationals of Cameroon who attempt to travel to the United States after April 14, 2022, will not be eligible for Temporary Protected Status.
TPS applicants must meet all eligibility requirements and undergo security and background checks to gain approval.
What will be discussed during the webinar session?
During the webinar, USCIS will provide an overview of the designation of Cameroon for TPS and then hold a question-and-answer session. USCIS cautions the public that it will not be addressing case-specific questions, questions outside the scope of the engagement, or issues under active litigation.
To Register for the Webinar:
Individuals must visit the registration page.
You will be asked to provide your email address and select "Submit."
On the next screen, you will see a notification that you successfully subscribed to this event.
Once your registration is complete, you will receive a confirmation email with additional details.
If you have not received a confirmation email within three business days, you may email at public.engagement@uscis.dhs.gov.
For more information about Cameroon's TPS designation please click here.
Posted in: Biden administration, Cameroon, DHS, EAD, EAD Renewal, First Time Clients, Free Consultation, Global Immigration, I-821, News, Temporary Protected Status, TPS, TPS Re-Registration, USCIS, Webinars and Work permits
Updated: August 29, 2022 10:10 pm
New USCIS Data Reveals Employment Authorization Processing Crisis for Asylum Seekers
Welcome back to Visalawyerblog. We kick off the start of a brand-new week with unfortunate news for asylum-based applicants for I-765 employment authorization.
New data from the U.S. Citizenship and Immigration Services (USCIS) indicates that the agency has been woefully inadequate at processing work permits, failing to meet the 30-day required processing time for employment authorization cards, also known as EADs, filed by asylum seekers.
By law, USCIS must process work permits (EADs) within 30 days of receipt of an asylum seekers I-765 application for employment authorization. However new data shows that USCIS has not been meeting this required timeline throughout 2022, and processing has been declining to a record low.
Data released by USCIS, as part of ongoing litigation, shows that during the last three weeks of February 2022, 93 percent of I-765 applications had been pending for at least 30 days. In March 2022, this figure plummeted to just 68 percent of I-765's being processed within the 30 days. Sadly, in recent months, the data shows that processing of EADs has been getting worse and worse on a monthly basis. For instance, in April of this year, this figure dropped to 41 percent of I-765 applications being processed within 30 days. In May the drop continued to just 21 percent, and in June to just 6 percent. Finally, this past month of July, the agency processed less than 5 percent of EAD applications within the required 30-day window. This trend puts on full display the asylum visa processing crisis with no end in sight.
The drop in EAD processing coincides directly with a court ruling handed down in February. USCIS appears to be clearing out the backlog by first processing work permit applications pending the longest, creating substantial delays for more recent applications for employment authorization.
The data indicates that the vast majority of applications USCIS processed over the past three months had been pending for more than 120 days (nearly 4 months).
Due to the EAD processing crisis, USCIS now faces a backlog of more than 77,000 pending work permit requests received by the agency within the past three months alone.
Posted in: Affirmative Asylum, Asylum, Asylum Law, Backlogs, Biden administration, Defensive Asylum, Delays, DHS, EAD, EAD Renewal, Employment Authorization Document, Expedite Requests, First Time Clients, Free Consultation, Global Immigration, I-765, Immigrant Visas, News, Permanent Residents, Special Immigrants, Special Situations, USCIS, USCIS Backlogs and Work permits
Immigration Updates: USCIS Announces I-589 Asylum Receipt Notice Issuance Delays and I-765 E-Filing for (C)(11) Parolees
In this blog post, we share with you the latest immigration updates from the U.S. Citizenship and Immigration Services.
I-589 Application for Asylum and Withholding of Removal Receipt Notice Delays
More blunders are being made at USCIS service centers. On July 28, USCIS announced delays in the issuance of receipt notices for Form I-589, Applications for Asylum and for Withholding of Removal, stating that applicants may not receive their notices in a timely manner.
With respect to the 1-year filing deadline for asylum, the filing date will still be the date that USCIS received your properly filed Form I-589 (not the date it was processed).
Applications that were not properly filed will be rejected and deficiencies will be noted in the filing. USCIS reminds applicants that if they have not received their receipt notices in a timely manner, they should not submit multiple Forms I-589, as it will result in case delays.
USCIS has provided the following reminders to help applicants determine whether their form I-589 was properly filed to prevent further delays:
You must submit your application for asylum within one year of arriving in the United States (one-year filing deadline), unless you can establish that there are changed circumstances that materially affect your eligibility for asylum or extraordinary circumstances directly related to your failure to file within one year.
You must type or print all of your answers in black ink.
You must provide the specific information requested about you and your family and answer all the questions on the form. If any question does not apply to you or you do not know the information requested, answer "none," "not applicable," or "unknown."
If you file your application with missing information, we may return it to you as incomplete.
Posted in: Asylum, Asylum Law, EAD, EAD Renewal, First Time Clients, Free Consultation, Global Immigration, I-589, I-765, News, USCIS, USCIS Backlogs, USCIS Service Centers and Work permits


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No-one's safe from the whimsical charms of our frozen tormentors, the poros. Their distilled adorability has taken the community by storm and when that happens, the arts follow! There's more to this showcase than abominable furballs though: we've also got illustrations, scratchboards, dolls and more, so get your click on and check out the cream of the community's creation crop!
What's that noise on the roof? It's a hailstorm of poro-tastic submissions raining down from the community. Akya, Paulishuku and Glakos bring us poro plushies. Nikkels and Titivilus show off their furball illustration skills. Finally, April Mist made poro keychains with spot-on lolling tongues and shining eyes.
Alice Sama packs a wallop in this Vi cosplay. Not only does she nail the gauntleted-gal's armor, she pulls it off with perfect pink hair. Ka-pow!
Kalagirl's illustration renders Zyra's vivid hues in full bloom, but beware! Every terrifying plant-woman has her thorns.
Kaerri8's scratchboard rendering of Ziggs is a black and white imagining of the sheer joy that everyone's favorite bombastic yordle plies from his chief hobby.
J Troublez crafted this Trundle doll as an offering of tribute to the newly crowned Troll King. The only question is how a troll so cute can still look so ANGRY.
Remember summoners, next time it could be your arts and crafts being shown off to the community at large. Drop your eminently showcaseable creations in our inbox!


With venture capital investments growing at a faster right than ever before, it's not a bad time to be a startup. According to the MoneyTree report released last week, investors dished out double the amount to startups this past quarter than they did during the same period of 2013.
While there has been a proliferation of venture capital investments in startups across the board, investments have been largely focused in technology startups. The reason for this is attributed to the fact that technology startups are staying private longer and venture capital firms are chasing returns in fast growing private companies.
All in all, the MoneyTree report shows that software startups got the most funding of any other sector during the first quarter in 2014. The second biggest category for venture investments was in biotech startups, while the third category was in medical devices and equipment.
Fortunately for startups, as long as the amount of capital available for investment in startups keeps rising, startups will continue receiving big checks from venture capitalists. This is due to the fact that hedge funds and private equity firms are increasingly joining venture capitalists.
Instead of raising just enough money for the next 18 months, startups are now raising all the money they could possibly need in one fell swoop. As these grand investments in startups continue, we can expect to see a tremendous surge in startups across the nation.
The takeaway here: It truly is a GREAT time to be a startup.


Abundant Solar is a full-service solar provider. We are passionate about sales, leadership, personal development and recruiting. Our employees aren't just our greatest asset but are the purpose of our company. We find leaders who want to win and help give them the skills to accomplish much more than they ever thought possible.
We are currently seeking to hire an Outside Sales Manager to oversee and lead door to door solar sales reps in our San Antonio Texas market. More specifically we as a company do a good job of hiring, on-boarding, training and preparing door to door sales reps to sell solar. But we need someone with experience to help them set their leads and close their deals till they are self-sustaining.
If you feel you could be the right fit for us, please Apply!
Why Work at This Company?
Fun culture, learning environment, success oriented, and room for growth.


text:
A Box of Rain
Jump down to see edition details for: Hardcover | Paperback
Publisher Viking Pr
Publication date October 1, 1990
Book category Adult Non-Fiction
Availability§ Out of Print
Original list price $24.95
Amazon.com says people who bought this book also bought:
DeadBase 50: Celebrating 50 Years of the Grateful Dead | DeadBase 50: Celebrating 50 Years of the Grateful Dead | The Complete Annotated Grateful Dead Lyrics | Jerry on Jerry
A collection of more then 250 song lyrics by Robert Hunter includes all his songs written for the Grateful Dead, Jerry Garcia, other artists, and those performed by Hunter himself, along with epic song-poems that have only been partially recorded
Amazon.com description: Product Description: A collection of over 250 classic songs by the main lyricist for the Grateful Dead--with a new introduction and over 20 additional songs, including from the Dead's next album. Hunter also explains the sources of certain songs and describes the evolution of others over years of performance. Complete discography.
from Viking Pr (October 1, 1990)
About: A collection of more then 250 song lyrics by Robert Hunter includes all his songs written for the Grateful Dead, Jerry Garcia, other artists, and those performed by Hunter himself, along with epic song-poems that have only been partially recorded
Rep sub edition from Penguin USA (November 1, 1993)
9780140134513 | details & prices | 7.25 × 9.50 × 1.25 in. | 1.40 lbs | List price $20.00
from Viking Pr (November 1, 1991)


text:
Rafael Nadal Makes Much Awaited Return in Cincinnati: "I am happy to be back.."
Rafael Nadal is ready to make his first appearance in the 2022 North-American Hard Courts season as he reaches Cincinnati to play in the Western and Southern Open for the first time in five years.
Nadal has been out of the court since his withdrawal from the 2022 Wimbledon Championship semi-finals game against Nick Kyrgios. After missing several hard court tournaments, including the Canadian Open, the 22-time grand slam champion is set to make his much-awaited return in the Cincinnati Masters 2022 this week on Wednesday.
The Cincinnati Masters (also known as the Western and Southern Open) is currently underway with the rounds of 64 being played right now. Nadal, seeded 2nd in the tournament, has gotten a bye in the first round. The Spaniard will play either Lorenzo Musseti or Borna Coric in the round of 32.
Earlier this week, Nadal talked about how he feels about coming back to Cincinnati and also his chance of regaining the no. 1 spot in the ATP rankings in the pre-tournament press conference. When asked to reflect on how he feels about his return to Cincinnati, the 36-year-old replied, "I am happy to be back in Cincinnati after a couple of years. I am having a good season and I am enjoying it. I want to enjoy this week in Cincinnati."
With the current world no. 1, Daniil Medvedev getting knocked out in the first round of the Canadian Open last week, Nadal is presented with a chance to climb back to the world no. 1 in the ATP rankings. "It means a lot to me to have that opportunity (to regain no. 1). Something that I didn't expect could happen again. The main thing is to stay healthy and play the events that I want to play," stated Nadal
"I am going to put all my efforts into every single event I play. It is something that doesn't matter if I have the chance to be No. 1, but I am happy to be in this position and if it happens, I will be very happy." added the world no. 2.
Rafael Nadal won the Cincinnati Masters trophy only once in his career in 2013. Considering how incredible a year he is having in 2022, it is likely that we see Nadal win his fifth title of the year in Cincinnati.


GLO CLEVELAND is a movement. We provide opportunities for the creative class to incubate ideas utilizing our platforms. Our studio space and pop up shop showcase a variety of local brands, artists, performers, designers, photographers and more. We have 5000 square feet of blank canvas for you.
We are where creatives come to play. Look out for us popping up in your community or come experience the light at our unique space. Also, enjoy our own line of apparel and products, always in development. Have an idea? Let us know.
We sell our own custom apparel and carry local brands, art and more on consignment.


Moda Blockheads BOW #20 is called Devil's Claws by Betsy Chutchian. It is a lovely block and easy to do, but I'm sorry to say that I did not do it justice. By not following the very clear directions I will lose some of my points when I join the block to my others. This is what happens when I get distracted. I WILL be redoing this one.
The instructions to this block and all previous blocks are on the Moda Fabrics Blog site.


text:
Periods of rain and snow. Temps nearly steady in the mid to upper 30s. Winds NE at 5 to 10 mph. Chance of precip 90%..
Snow this evening will taper off to light snow late. Low 34F. Winds NNE at 5 to 10 mph. Chance of snow 80%. Snow accumulating 1 to 3 inches.
Memphis puts road win streak on the line against Minnesota
Memphis Grizzlies (5-6, 10th in the Western Conference) vs. Minnesota Timberwolves (3-8, 15th in the Western Conference)
Minneapolis; Friday, 8 p.m. EST
BOTTOM LINE: Memphis will try to keep its three-game road win streak intact when the Grizzlies face Minnesota.
Minnesota went 19-45 overall and 8-24 at home a season ago. The Timberwolves gave up 117.5 points per game while committing 21.4 fouls last season.
Memphis went 34-39 overall and 20-26 in Western Conference play during the 2019-20 season. The Grizzlies averaged 26.9 assists per game on 42.6 made field goals last season.
Minnesota and Memphis square off for the second time this season. The Grizzlies won the last meeting 118-107 on Jan. 13. Jonas Valanciunas led Memphis to the win with 24 points, 16 rebounds and two blocks.
INJURIES: Timberwolves: Jake Layman: out (personal).
Grizzlies: Jontay Porter: out (knee), Killian Tillie: out (hip), Jaren Jackson Jr.: out (knee), Ja Morant: out (ankle), Justise Winslow: out (hip).
© 2021 Data Skrive. All rights reserved.


text:
Olímpico Internacional (COI) é uma organização não governamental. Foi criada em 23 de junho de 1894, por iniciativa de Pierre de Coubertin, com a finalidade de reinstituir os Jogos Olímpicos realizados na antiga Grécia e organizar e promover a sua realização de quatro em quatro anos.

O COI é financiado através de publicidade e comercialização de artigos comemorativos dos Jogos e através da venda dos direitos de transmissão dos eventos Olímpicos.

Em 1896, após uma pausa de 1 500 anos, realizaram-se os primeiros Jogos Olímpicos da era moderna, que o barão de Coubertin esperava ajudassem a fomentar a comunicação e paz internacional.

Atualmente, o objetivo do COI é a administrar e legislar sobre os Jogos, e também servir como entidade legal que detém os direitos de autor, marcas registradas e outras propriedades relacionadas com os Jogos Olímpicos. Por exemplo, a Bandeira Olímpica, o Lema Olímpico e o Hino Olímpico pertencem e são administrados pelo COI. Adicionalmente há outras organizações, nomeadamente os Comités Olímpicos Nacionais e as Federações Esportivas Internacionais, que são controladas pelo COI e que coletivamente são designadas por "Movimento Olímpico".

As cidades que desejarem ser sedes dos Jogos Olímpicos de Verão ou de Inverno devem entregar uma proposta candidatura para seus Comitês Olímpicos Nacionais que devem autorizar ou não a sua candidatura. Estes devem entregar a proposta de organização ao COI, que tem a palavra final na decisão de onde se realizarão os Jogos, através da votação de delegados que representam a maioria dos países-membros. Por lei, todos os membros do COI têm de se retirar ao atingir 81 anos de idade.

Missão e objetivos
A Carta Olímpica define que o Comitê Olímpico Internacional é responsável por:
 Incentivar e apoiar a organização, desenvolvimento e coordenação de competições esportivas e esportivas;
 Assegurar a celebração regular dos Jogos Olímpicos;
 Cooperar com as organizações e autoridades públicas ou privadas competentes na tentativa de colocar o esporte a serviço da humanidade e, assim, promover a paz;
 Atuar contra qualquer forma de discriminação que afete o Movimento Olímpico;
 Incentivar e apoiar a promoção das mulheres no desporto a todos os níveis e em todas as estruturas, com vista a implementar o princípio da igualdade entre homens e mulheres.

Presidentes

O presidente do COI é responsável por representar o COI como um todo e tomar decisões por ele quando o Conselho Executivo não está apto a se reunir. Desde 1894 o COI teve oito presidentes.

O atual presidente é o alemão Thomas Bach, que ocupa a posição desde 2013.

Ver também
 Comité Paralímpico Internacional
 Lista de países por código do COI

Ligações externas

Organizações esportivas fundadas em 1894
Observadores da Assembleia Geral das Nações Unidas