text:
Your First Prenatal Visit
Pre-pregnancy Health Check
Symptoms of Pregnancy
Diet for a Healthy Pregnancy
The skin in pregnancy
Diagnosis of pregnancy
Mixed Incontinence
Bypass Incontinence
Overflow Incontinence
Disorders During Pregnancy
Hypertensive States of Pregnancy
- Preeclampsia
- Eclampsia
- Chronic Hypertension
Diabetes Mellitus and Pregnancy
- Type 1 Diabetes
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Medical conditions complicating pregnancy
Facts About Ovulation
Home Pregnancy Tests
Are You Ovulating?
Facts On Infertility
Hi-Tech Solutions for Infertility
Treating Infertility With Herbs
Birthing Alternatives
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Contraception for Adolescents
Menstrual Irregularities
Adolescent Dysmenorrhea
Ovarian Masses
Precocious Puberty
Vulvo-Vaginal Disorders
Cervical Polyps
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Gynecology news |
New Finding May Help Explain Development of Preeclampsia
Feb 08, 2008 Viewed: 650
In a study of pregnant women, those with pregnancy-induced high blood pressure were found to have higher levels of a peptide that raises blood pressure in the pieces of tissue linking mother and fetus, according to researchers at Wake Forest University Baptist Medical Center. The finding, reported online in the journal Hypertension, may help explain how the disorder develops.
Preeclampsia, or high blood pressure induced by pregnancy, affects 7 to 10 percent of pregnancies in the United States and is the second-leading cause of maternal mortality. It is the leading cause of pre-term delivery and contributes significantly to stillbirths and death in newborns.
The researchers found that in women with preeclampsia, levels of angiotensin II (Ang II), a hormone that constricts blood vessels and causes blood pressure to rise, was doubled in the chorionic villi, part of the placenta that links mother and fetus and supplies food and oxygen.
"This finding may be part of the preeclampsia puzzle," said Lauren Anton, a graduate student who is first author on the research. "Anything that gets us closer to understanding this disease is important because there is no treatment and no cure and women are still delivering babies too early."
The researchers theorize that Ang II may restrict the fetal vessels that lie within the chorionic villi, which not only raises blood pressure, but also lowers oxygen and nutrient flow to the baby and may result in lower birth weight and other complications of preeclampsia.
The study involved 21 women with preeclampsia and 25 women without the disorder. After delivery, tissue sections were taken from the center of the placenta for analysis.
Ang II is part of the renin angiotensin system (RAS) that regulates blood pressure. The system has been shown to play an important role in preeclampsia. However, changes in the system also occur in women who don't develop the condition. In normal pregnancies, estrogen causes increased levels of several hormones, including Ang II, in the blood. Despite the increase of Ang II in the blood during pregnancy, most women do not develop preeclampsia.
This the first study to demonstrate that all three peptides involved in the RAS are found in the chorionic villi of both normal and preeclamptic women. And, it was the first to show that levels of Ang II are higher in the chorionic villi of women with preeclampsia.
"This implies that local tissues are contributing to the problem," said K. Bridget Brosnihan, Ph.D., senior researcher, who has been studying preeclampsia for 12 years. "The hormone is remarkably elevated in this relatively small tissue, which implies that it has an important role in the development of preeclampsia."
The researchers hope that the findings may one day lead to treatment for preeclampsia.
ACE inhibitor drugs are currently used to lower Ang II in non-pregnant women with hypertension, but these drugs cannot be given to pregnant women. The study authors suggest that other therapies aimed at regulating blood pressure might be beneficial if they target the chorionic villi rather than the system as a whole. They are currently working to determine if growth factors that cause the placenta's blood supply to develop may also be regulated by the increase in Ang II.
The study was supported, in part, by the National Institutes of Health and the American Heart Association. It was published in the Go Red issue of Hypertension that is dedicated to women's cardiovascular health.
Co-researchers are David Merrill, M.D., Ph.D., Liomar Neves, Ph.D., Kathryn Stovall, B.S., Patricia Gallagher, Ph.D., Debra Diz, Ph.D., Cheryl Moorefield, R.N., Courtney Gruver, R.N., and Carlos Ferrario, M.D., all with Wake Forest.
Wake Forest University Baptist Medical Center is an academic health system comprised of North Carolina Baptist Hospital, Brenner Children's Hospital and Wake Forest University Health Sciences, which operates the university's School of Medicine and Piedmont Triad Research Park. The system comprises 1,154 acute care, rehabilitation and long-term care beds and has been ranked as one of "America's Best Hospitals" by U.S. News & World Report since 1993. Wake Forest Baptist is ranked 32nd in the nation by America's Top Doctors for the number of its doctors considered best by their peers. The institution ranks in the top third in funding by the National Institutes of Health and 4th in the Southeastern United States in revenues from its licensed intellectual property.
Source: Wake Forest University Baptist Medical Center
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Natural Products (Pro)
Calanolide A
Scientific Name(s): Calophyllum lanigerum var. austrocoriaceum
Common Name(s): Calanolide A
Medically reviewed by Drugs.com. Last updated on Sep 14, 2020.
Clinical Overview
Calanolide has demonstrated antimicrobial activity, and interest focuses on applications in HIV; however, clinical studies are lacking.
Calanolide A is an investigational anti-HIV drug that has been given in early clinical trials at an oral dose of 200 to 800 mg; however, it is not available for use. Its safety and efficacy remain to be defined.
Contraindications have not yet been identified.
Pregnancy/Lactation
Information regarding safety and efficacy in pregnancy and lactation is lacking.
None well documented.
Because this product is a relatively new discovery, no data are available.
Calanolide A is an investigational anti-HIV drug. Its safety and efficacy remain to be defined.
Scientific Family
Clusiaceae (Mangosteen)
Calanolide A is a compound isolated from the latex of the tree Calophyllum lanigerum var. austrocoriaceum that grows in the rain forest of the Malaysian state of Sarawak on the island of Borneo. There are at least 200 species in the genus Calophyllum.McKee 1998, Shenon 1994, USDA 2016
Rain forests are a very promising source of natural medicines because of their vast diversity. It has been estimated that more than half of the world's 250,000 plant species exist in tropical rain forests. Searching for natural drugs in these areas, the National Cancer Institute (NCI) contracts scientists to gather specimens for analysis. In 1987, an Illinois team obtained samples from many trees, one of which was Calophyllum lanigerum. Four years later, the NCI discovered that a preparation from this gum tree was active against the human immunodeficiency virus type 1 (HIV-1).Defant 2015, Shenon 1994
Plants from the genus Calophyllum have been shown to contain xanthones, steroids, triterpenes, coumarins, and benzopyrans. Calanolide A is considered a dipyranocoumarin, with nonnucleoside HIV-1 specific reverse transcriptase inhibiting properties. McKee 1998, McKee 1996 Many studies in this area discuss findings from the genus Calophyllum, and offer structural representations, related compounds and their derivatives, modifications of the molecule, etc.Galinis 1996, Kashman 1992, Ma 2008, McKee 1998, McKee 1996, Sekino 2004, Yu 2007, Zembower 1997 Calanolide A has been synthesized in the lab and was found to have similar actions to the natural product.Flavin 1996
Uses and Pharmacology
Antiviral activity
Calanolide A and other related compounds from the genus Calophyllum have demonstrated antiviral activity including nonnucleoside reverse transcriptase inhibition,Matthee 1999, Newman 1998 and activity against influenza H3N1 and H1N1 viruses.Rajasekaran 2013
Early interest in Calophyllum extracts in the management of HIV infections persists,Matthee 1999, Newman 1998 particularly as an option for clinically relevant mutant HIV strains.Usach 2013
Calanolide A is being investigated in phase I clinical trials for safety, tolerability, and pharmacokinetics.Creagh 2001, Usach 2013
Other effects
Calanolide A is being investigated as an anti-tumor agentDefant 2015 and for activity against Mycobacterium tuberculosis.Liu 2015
Calanolide A is an investigational anti-HIV drug that has been given in early clinical trials at an oral dose of 200 to 800 mg; however, it is not available for use. Safety and efficacy remain to be defined.Creagh 2001
Pregnancy / Lactation
Information is limited.Creagh 2001, Usach 2013
Information is limited.
Creagh T, Ruckle JL, Tolbert DT, et al. Safety and pharmacokinetics of single doses of (+)-calanolide a, a novel, naturally occurring nonnucleoside reverse transcriptase inhibitor, in healthy, human immunodeficiency virus-negative human subjects. Antimicrob Agents Chemother. 2001;45:1379-1386.11302799
Defant A, Mancini I, Tomazzolli R, Balzarini J. Design, synthesis, and biological evaluation of novel 2H-pyran-2-one derivatives as potential HIV-1 reverse transcriptase inhibitors. Arch Pharm (Weinheim). 2015;348(1):23-33.25523431
Flavin M, et al. Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (+/-)-calanolide A and its enantiomers. J Med Chem. 1996;39(6):1303-13.8632437
Galinis D, et al. Structure-activity modifications of the HIV-1 inhibitors (+)- calanolide A and (-)-calanolide B. J Med Chem. 1996;39(22):4507-10.8893846
Genus Calophyllum L. USDA, NRCS. 2016. The PLANTS Database (http://plants.usda.gov, September 2016). National Plant Data Team, Greensboro, NC 27401-4901 USA. Accesssed September 2016.
Kashman Y, et al. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum. J Med Chem. 1992;35(15):2735-43.1379639
Liu Z, Guo X, Liu G. Modified calanolides incorporated with furan-2-nitro mimics against Mycobacterium tuberculosis. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1297-300. doi: 10.1016/j.bmcl.2015.01.04625681226
Ma T, Liu L, Xue H, et al. Chemical library and structure-activity relationships of 11-demethyl-12-oxo calanolide A analogues as anti-HIV-1 agents. J Med Chem. 2008;51(5):1432-1446.18284187
Matthee G, et al. HIV reverse transcriptase inhibitors of natural origin. Planta Med. 1999;65(6):493-506.10483367
McKee T, et al. New pyranocoumarins isolated from Calophyllum lanigerum and Calophyllum teysmannii. J Nat Prod. 1996;59:754–58.8792623
McKee T, et al. Pyranocoumarins from tropical species of the genus Calophyllum: A chemotaxonomic study of extracts in the National Cancer Institute Collection. J Nat Prod. 1998;61:1252-56.9784162
Newman R, et al. Pharmaceutical properties of related calanolide compounds with activity against human immunodeficiency virus. J Pharm Sci. 1998;87(9):1077-80.9724557
Rajasekaran D, Palombo EA, Chia YT, et al. Identification of traditional medicinal plant extracts with novel anti-influenza activity. PLoS ONE. 2013;8(11):e79293.
Sekino E, Kumamoto T, Tanaka T, Ikeda T, Ishikawa T. Concise synthesis of anti-HIV-1 active (+)-inophyllum B and (+)-calanolide A by application of (-)-quinine-catalyzed intramolecular oxo-Michael addition. J Org Chem. 2004;69(8):2760-2767.15074925
Shenon P. Hunt in forests of Borneo aims to track down natural drugs. New York Times. 1994 Dec 6.
Usach I, Melis V, Peris JE. Non-nucleoside reverse transcriptase inhibitors: a review on pharmacokinetics, pharmacodynamics, safety and tolerability. J Int AIDS Soc. 2013 Sep 4;16:1-14. doi: 10.7448/IAS.16.1.18567.24008177
Yu D, Morris-Natschke SL, Lee KH. New developments in natural products-based anti-AIDS research. Med Res Rev. 2007;27(1):108-132.16888749
Zembower D, et al. Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-0l ring (ring C). J Med Chem. 1997;40(6):1005-17.9083491
This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.
This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.
Copyright © 2020 Wolters Kluwer Health
More about calanolide a
Pregnancy Category Not classified N
Truvada, tenofovir, Atripla, Stribild, Complera, Epzicom

redpajama_set_name: RedPajamaCommonCrawl


This blouse original will be your believer associated because you will be able to wear it with garments sophisticated for a night look or with your basic for the everyday life. Blouse with V-neck raised by metallic can be buttonholes or eyeholes and adjustable tie to your taste, with detail of ruffles that provide movement. Long sleeve drapeen with steering wheel detail and finished with cuff and button. Of asymmetrical cut, longer in the back, polyester is made of semi-transparent fabric 100%. And take of gift an interior t-shirt of fine spaguetti suspenders made of soft knit 100% viscose.


After a couple of years, you get to a point in your young parenting life when you relinquish the ideas of your former self. Last year I converted my old work/workout area into a inspired writer's nook. A lovely thought, right? Over a year later, I believe I wrote from that spot a total of three times. If I got a chance to work on my writing, it was likely at the dining room table in between making dinner, doing some work and cleaning up crayons. Our once adult basement slowly transformed. With large plastic toys cluttering the basement TV viewing area, the man cave part of the basement was a man cave no more. So I threw up the white flag. Mommy surrender.
My once serene writer's nook has been transformed into a toddler's playroom. The sacrifice was worth the reward. We now have friends over to watch a game while the kids quietly (or not so quietly) play right behind us, and we know they are safe. I plan on showing the full playroom in weeks to come when I finish the cute sporty touches, but for now, I wanted to share a little fun art corner addition.
Our toy room is sectioned off by two three foot tall walls that divide the room. I decided it was the perfect height and length to turn it into a chalkboard wall for Lincoln and his friends. Originally, I just planned on painting the wall, until I discovered chalkboard contact paper. Much less fuss, much less smell, much less mess and hopefully easier to clean up if I decide I do not want it anymore.
I ordered the contact paper through Amazon. I needed two rolls to fill our wall space. It is easiest to have someone help you to reduce the amount of bubbles in the paper.
The process is pretty simple. Cut your paper to the length of your space (I made mine a little longer and cut it off at the end). Peel of the back of the contact paper. Starting at the top of the wall, press across then down. Continue this until you reach the bottom. Pull downward and a little bit outward with the paper to avoid bubbles. Use a credit card to smooth the paper and adhere it to the wall. Cut the extra edges (if you have any) with a scissors. If you have any small overlaps over molding or at the corners, take an Exacto knife and simply slice off the extra pieces, being careful not to slice the wall. Repeat with as many pieces as you need to fill your space. Make sure to line up your paper and make as few seams as possible.
Lincoln was very excited to get to play on his new chalkboard wall and I am happy as a clam typing with my Mac in my lap or on the table. Life may not be what it used to be, but life is pretty darn good.
I've got something cooking for the other side, which I will share in the future. I plan to use the leftover contact paper for some fun projects too. Stay tuned!
this is awesome – so fun!
it was so nice to meet you last week!! i hope we can chat again soon.
Thanks! It was great to meet you too! Hopefully we will meet up again!


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World Leaders React to Deadly Sri Lanka Blasts
Posted By: Moaz Awad 0 Comment World Leaders React to Deadly Sri Lanka Blasts
COLOMBO: World leaders have condemned a series of blasts in Sri Lanka that killed more than 150 people on Sunday, including dozens of foreigners — with British, Dutch and American citizens believed to be among them.
Hospital sources also said Japanese citizens were among those injured by the bombs which ripped through high-end hotels and churches holding Easter services.
Here is a summary of the reactions:
Pope Francis condemned the attacks as "such cruel violence" and said he was close to the Christian community, hit while celebrating Easter.
British Prime Minister Theresa May described the attacks as "truly appalling."
"The acts of violence against churches and hotels in Sri Lanka are truly appalling, and my deepest sympathies go out to all of those affected at this tragic time," she tweeted.
"We must stand together to make sure that no one should ever have to practice their faith in fear."
"Terrible reports from Sri Lanka about bloody attacks on hotels and churches on this Easter Sunday," Dutch Prime Minister Mark Rutte tweeted after the attacks first emerged.
"Thoughts are with the victims and their relatives."
Prime Minister Scott Morrison said Australia was thinking of those killed in a "horrific terrorist attack."
"To the beautiful people of Sri Lanka, Australia sends its heartfelt sympathies and our prayers and our support — and our offer to do whatever we can to support you in this terrible time of need," he said in a statement.
"At this time as Easter Sunday draws to a conclusion here in Australia, our heart goes out to those Christians and all of those other innocents who have been slaughtered today in this horrific terrorist attack."
A month after dozens of Muslims were killed in a shooting at two mosques in Christchurch, New Zealand Prime Minister Jacinda Ardern described the attack as "devastating."
"New Zealand condemns all acts of terrorism, and our resolve has only been strengthened by the attack on our soil on the 15th of March. To see an attack in Sri Lanka while people were in churches and at hotels is devastating.
"New Zealand rejects all forms of extremism and stands for freedom of religion and the right to worship safely. Collectively we must find the will and the answers to end such violence."
Catholic Church in Jerusalem
The Catholic Church in Jerusalem said the blasts were particularly sad as they "came while Christians celebrate Easter."
"We pray for the souls of the victims and ask for speedy recovery of the injured, and ask God to inspire the terrorists to repent of their killing and intimidation," the statement said.
"We also express our solidarity with Sri Lanka and all its inhabitants in their various religious and ethnic backgrounds."
Indian Prime Minister Narendra Modi also expressed solidarity with the fellow South Asian country, and said "there is no place for barbarism in our region."
Imran Khan also took to Twitter to condemn the attacks, saying: "My profound condolences go to our Sri Lankan brethren."
Iran's foreign minister says he is "terribly saddened" by the Easter Sunday bombings.
Mohammad Javad Zarif tweeted that "terrorism is a global menace with no religion: it must be condemned & confronted globally."
In Nod to Debt Concerns, China Belt and Road Summit to Urge Sustainable Financing
Experts: Reduction of dollar exchange rate does not mean immediate inflation rate drop
Hong Kong Suspends Subway and Train Services, Appeals to Public after Rioting
October 6, 2019 Moaz Awad 0
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Security of Global Energy Is At Risk
AAAID Inaugurates Wheat Harvest in Gezira Scheme
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text:
You are at:Home»News»Defense»Airbus begins A400M flight test program for SAF
Airbus begins A400M flight test program for SAF
By Web Team on 14th September 2022 Defense, Flight Testing
The flight test program to show that the A400M military transport aircraft can be run on SAF (Image: Airbus)
Airbus is flight testing the A400M with SAF, with the flight test flight campaign starting with a successful first flight using a 29% mix of the drop-in biofuel earlier this summer.
The Sustainable Aviation Fuel (SAF), a biofuel made of residuals of oils, vegetables and fats, was tested on A400M test aircraft MSN4, known as Grizzly 4 by the flight test team, by the Military Air Systems unit of Airbus Defence and Space at Airbus´ San Pablo plant in Seville, Spain.
During the first test flight, engine number 2 of the aircraft was run on a blended load of 29% SAF. The use of SAF was limited to one engine to better analyze the fuel system´s behavior feeding a single engine.
The flight headed towards the North of Huelva and landed back in Seville, making a trip of more than an hour in total.
César González, flight test engineer at Airbus Defence and Space said, "During the flight, we performed a close comparison between engine number 2, the one using SAF, and the other 3 engines using standard fuel Jet A1, so we had a very good opportunity to compare the performance of the different fuels.
"The results we got confirmed that using this blended SAF does not affect engines or aircraft performance, so the A400M can receive the whole potential of it in terms of environmental benefit", González added.
This flight demonstrated that both the aircraft and its TP400-D6 engines, can meet the new fuel requirements with a blend of 50% certified SAF for a more sustainable military aviation.
Airbus and the maker of the A400M's TP400-D6 turboprop engines EuroProp International are to establish a roadmap towards 100% SAF certification for the aircraft.
"This flight is a significant step forward, and relying on the expertise of our parent companies, we are confident that TP400-D6 robust design will enable us to reach the highest SAF standards", said Stephan Schlisske, head of design organisation at Europrop International.
More than 100 A400M aircraft are deployed in 8 different countries. Rocío Gutierrez Alonso, chief engineer of A400M power plant said, "Our operators had expressed their willingness to use SAF in their military operations, and we are here to respond to their needs. After running all flight test procedures and performing the required ground tests analysis, the engineering team gave the green light to this first test flight with SAF.
The Grizzly 4 A400M test aircraft has been in use since December 2010, including the development and certification of AAR (air to air refueling) capabilities as a tanker and receiver and also for cargo and parachute drops, as it was designed in such a way that the cargo hold was free of instrumentation and therefore, fully usable for aerial delivery or additional fuel tanks (CHT).
This first flight with SAF is number F994 in the MSN4´s service record, so it is only six more flights away from being retired after nearly 2,000 flight hours.
"This flight of an A400M using SAF is a first step in our division that creates the momentum to progress steadily and persistently at an efficient pace along a path towards sustainability", Gutiérrez said. "More flight tests with SAF are planned for the coming months for the C295 and the A330 MRTT, which will soon join the A400M in this fascinating race towards sustainable military aviation."
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Caroline Rowland (* 1971) ist eine britische Psychologin. Seit 2016 ist sie Direktorin am Max-Planck-Institut für Psycholinguistik in Nijmegen (Niederlande).

Leben
Rowland studierte Psychologie an der University of Manchester und promovierte 2000 an der University of Nottingham. Ihre Promotionsschrift trug den Titel The acquisition of wh-questions in early English multi-word speech. Sie lehrte als Professorin für Entwicklungspsychologie an der University of Liverpool. Bis 2019 war sie Co-Direktorin von LuCid (ESRC International Centre for Language and Communicative Development), einer millionenschweren Zusammenarbeit zwischen den Universitäten von Manchester, Liverpool und Lancaster. Sie leitete zwischen 2014 und 2019 das Language 0-5 Projekt, das größte Projekt für die Erforschung der Sprachentwicklung von Kindern im Vereinigten Königreich.

Seit 2016 ist sie Direktorin am Max-Planck-Institut für Psycholinguistik und Professorin an der Radboud University.

Ihre Forschung konzentriert sich darauf, wie Kinder Sprache lernen. Dabei richtet sie ein Augenmerk auf Grammatik und darauf, wie die Umgebung des Kindes den Sprachgebrauch fördert und gestaltet. Dafür verwendet sie Experimente, Datenanalyse und Computermodelle.

Einzelnachweise

Wissenschaftliches Mitglied der Max-Planck-Gesellschaft
Psychologe
Brite
Engländer
Geboren 1971
Frau

redpajama_set_name: RedPajamaWikipedia


This link takes you directly to the State of California's river-flow database. It's a pretty impressive and extremely useful page -- not only can you find real-time flow data, but also water temperatures, information on scheduled reservoir releases, historical flow data, reservoir levels, and so on. (This is why we're not providing individual links to the rivers themselves -- you'd otherwise miss much of the site's utility for planning fishing trips.) Please note that you may have to make a click-thru or two to find the specific river you're interested in. Flows for the McCloud and Pit Rivers, for example, are reached using the "Sacramento River to Lake Shasta" button shown under the SACRAMENTO RIVER REGION heading.
This useful link provides real-time stream flow and reservoir storage data for Eastern Sierra waters managed by the Los Angeles Department of Water and Power.
With nearly 400 California streams listed, this site is an incredible resource for real-time and historical flow data. It somewhat duplicates the State of California (CDEC) site, but also presents a variety of rivers and creeks that have USGS rather than state-operated flow gauges. Finding a particular stream is a little tough, as listings tend to be clumped into large regional groups. But if you persevere, you'll likely locate what you're seeking.


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17 Altering Execution

Once you think you have found an error in your program, you might want to
find out for certain whether correcting the apparent error would lead to
correct results in the rest of the run.  You can find the answer by
experiment, using the gdb features for altering execution of the
program.

For example, you can store new values into variables or memory
locations, give your program a signal, restart it at a different
address, or even return prematurely from a function.

Assignment:                   Assignment to variables

Jumping:                      Continuing at a different address

Signaling:                    Giving your program a signal

Returning:                    Returning from a function

Calling:                      Calling your program's functions

Patching:                     Patching your program

redpajama_set_name: RedPajamaGithub


text:
What Kind Of Paper Is Acid On?
Drugs active in microgram range, most notably LSD, are commonly distributed illicitly on blotting paper. A liquid solution of the drug is applied to the blotting paper, which commonly is perforated into individual doses and artfully decorated with what is known as blotter art.
1 Is paper made with acid?
2 Is acid free paper?
3 What is blotter paper made of?
4 How is cotton rag paper made?
4.1 What is the importance of paper?
4.2 Which types of paper is used for newspaper?
4.3 What is a blotter used for?
4.4 Is cotton paper archival?
4.5 Can rag paper be recycled?
4.6 When was rag paper invented?
4.7 What is regular paper called?
4.8 What is acid free archival paper?
4.9 What is the paper size of a newspaper?
4.10 What did they sprinkle on ink?
Is paper made with acid?
Is 'normal' paper acidic? Standard paper made from wood pulp is indeed usually acidic, and becomes increasingly so the older it gets. The natural deterioration of Lignin (a natural part of plant cells in paper) causes the paper to become acidic and break down.
Is acid free paper?
Today, much of the commercially produced paper is acid-free, but this is largely the result of a shift from kaolin clay to precipitated calcium carbonate (PCC) as the main filler material in the pulp: PCC reacts with acids, and therefore requires the pulp to be chemically neutral or alkaline.
What is blotter paper made of?
Manufacture. Blotting paper is made from different materials of varying thickness, softness, etc. depending on the application. It is often made of cotton and manufactured on special paper machines.
How is cotton rag paper made?
Cotton paper, also known as rag paper or rag stock paper, is made using a cotton linter or cotton from used cloth (rags) as the primary material. … Cotton paper is superior in both strength and durability to wood pulp-based paper, which may contain high concentrations of acids, and also absorbs ink or toner better.
What is the importance of paper?
It is a versatile material with many uses, including printing, packaging, decorating, writing, cleaning, filter paper, wallpaper, book endpaper, conservation paper, laminated worktops, toilet tissue, currency and security paper and a number of industrial and construction processes. You may also read,
Which types of paper is used for newspaper?
Newsprint is a low-cost, non-archival paper consisting mainly of wood pulp and most commonly used to print newspapers and other publications and advertising material. Invented in 1844 by Charles Fenerty of Nova Scotia, Canada, it usually has an off white cast and distinctive feel. Check the answer of
What is a blotter used for?
Blotter may refer to: Blotting paper, used to absorb ink or oil from writing materials, particularly when quill or fountain pens were popular.
Is cotton paper archival?
Cotton paper is superior in both strength and durability to wood pulp-based paper. It is said that 1% of cotton equals one-year lifespan making cotton-based paper ideal for archival purposes, which is why cotton paper is known to last hundreds of years without appreciable fading, discolouration or deterioration. Read:
Can rag paper be recycled?
Recycling of used paper before the industrialisation of paper production, rag paper was recycled to make low-grade board. A process for removing printing inks from recycled paper was invented by German jurist Justus Claproth in 1774.
When was rag paper invented?
The Han dynasty Chinese court official Cai Lun (c. 50–121 CE) is credited as the inventor of a method of papermaking (inspired by wasps and bees) using rags and other plant fibers in 105 CE.
What is regular paper called?
In the United States and Canada the normal size of paper is called letter size, or sometimes US letter. It is 8 1⁄2 inches wide and 11 inches long (216 × 279 mm). The other common size of paper in the US is called legal, or sometimes US legal.
What is acid free archival paper?
Acid-free papers are made using alkaline paper making technology. This means the pH of the pulp that is used to form the paper is above 7 (neutral). The paper is also buffered with an alkaline reserve, such as calcium carbonate, to neutralize acid compounds absorbed from the atmosphere or formed through natural aging.
What is the paper size of a newspaper?
Width × Height (mm)
Width × Height (in)
Broadsheet 600 × 750 mm 23.622 × 29.528 in
Berliner 315 × 470 mm 12.402 × 18.504 in
Tabloid 280 × 430 mm 11.024 × 16.929 in
Compact 280 × 430 mm 11.024 × 16.929 in
What did they sprinkle on ink?
Pounce is a fine powder, most often made from powdered cuttlefish bone, that was used both to dry ink and to sprinkle on a rough writing surface to make it smooth enough for writing. … The pounce or sand is gently sprinkled all over the writing on the paper.
What Literary Genre Is The Phantom Of The Opera?
What Type Of Hearing Loss Did Beethoven Have?


…with great reason, of course. Bled is a great resort town. It (and its six boroughs) wraps around the beautiful Bled Lake, used by boaters and water skiiers in the summer. Sitting above Bled Lake in the above photo are Bled Castle and St. Martin's Church.
St. Martin's is similar to churches I've encountered among former Austro-Hungarian countries (don't know the name of the style). At the time the above photo was taken, Mass had recently concluded and the parishioners were enjoying a Sunday coffee in the church courtyard. The parishioners were of all ages, leaving one to imagine the same scene having taken place for decades, possibly centuries.
The castle also has a high-quality restaurant, and I thoroughly enjoyed my meal. It was a Slovene version of saumagen (basically a pork stomach stuffed with ground meats and chunks of sausage). It was far tastier than it sounds, and the Slovenia pilsner I had with it was very much on par with Austrian and German pilsners. And the meal was dirt cheap due to the exchange rate.
The island below is Bled Island, dominated by a 900-year old church that was the seat of Tyrolean bishops for eight centuries. In pamphlets I read at the castle, this church's floor has recently been excavated and underneath were the remnants of churches built in the early days of Christianity.
Sadly, given that this was a cold Sunday in November, I elected not to visit the island. But as you see below, there are dozens of wooden ferries making regular runs to the island in the summer.
The main town is loaded with resorts, so can imagine the crowds that better weather brings. Several new shopping centers have been built and all the top-name brands are on display. Still, it was nice to wander around the area and still see the lion's share of the area relatively untouched by the new hordes of visitors that have come since 1991.


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Amgen's John Kearney to be ABPI president
Linda Banks
The Association of the British Pharmaceutical Industry (ABPI) has appointed John Kearney as president. He will take up office on 24 April 2015, replacing Pfizer's Jonathan Emms who is relocating to the US.
John Kearney
John Kearney, general manager UK and Ireland at Amgen, has 35 years of experience in the industry, holding roles at GlaxoSmithKline and Pfizer before joining Amgen in 2007. He has been on the ABPI's board since 2008 and was closely involved in negotiations with the Department of Health to secure the 2014 Pharmaceutical Price Regulation Scheme (PPRS).
Stephen Whitehead, CEO of ABPI said: "I am delighted to be working alongside John as president. His unique experience and expertise across the industry will be crucial as he leads the ABPI and the UK pharmaceutical industry through the opportunities and challenges in 2015."
John Kearney added: "I am delighted to be building on the recent leadership of Jonathan Emms, at a time when the pharmaceutical industry as a whole is delivering such a high quality and quantity of new science and treatment innovations. I look forward to playing my part in ensuring those innovations are able to make a real difference in the funding and provision of health services, in the outstanding work of healthcare professionals in the UK, and – ultimately – to patients. I am committed to playing my part by listening to all those involved in planning and providing health services in the UK, and leading the ABPI in its engagement with them."
Jonathan Emms has been promoted to global marketing lead in Pfizer's global established pharmaceutical business, based in New York. He said, "It's been a great privilege to serve as ABPI president and I'm proud of what has been achieved during my tenure. The industry is recognised as a key sector for growth in the UK, but despite this we are operating against a backdrop of government austerity measures and an NHS budget under significant pressure."
He cautioned that there would be challenging discussions ahead with government over drug pricing, access and uptake, adding, "It is imperative that the one-off austerity contribution made by industry through the PPRS is met with good faith by the government, which must re-double its efforts to ensure that the agreement results in improved access to modern medicines."
Rising UK drugs bill raises fears of price controls


If you are currently planning out your wedding and if you are stuck for money or on an extremely tight budget there are many different ways that you can cut down costs on your wedding and still have the perfect day. To begin with, you can easily scrap the concept of a big white ball gown for your wedding and choose instead to wear a gorgeous coloured evening gown which will be much cheaper and potentially a lot more beautiful. Who knows, you may even end up setting a new trend. Many people tend to associate the white wedding gown with purity but the fact of the matter is that the only reason that anyone wears white on their wedding day is because queen Victoria chose to wear white one hundred years ago at her wedding and ended up setting a trend that was to last many centuries. Therefore, there is really no reason to wear something simply based on the fact that someone wore it one hundred years ago. Even the purity aspect, which has no basis whatsoever, does not make sense in this modern world where young people will almost always live together a few years before their wedding.
Event photography, especially for weddings can be extremely expensive and you find yourself spending massive amounts of money to a photographer who will spend a few hours taking a few pictures and then leave to the next wedding.
It is the same case with event videography in Singapore and although you will have some beautiful pictures by a professional, at the end of the day, they will be mostly posed pictures with no real passion in them.
One extremely creative ways of getting all your wedding memories without having to spend too much money is to ask your guests to take pictures of your wedding with their phones. They will do so anyway because we live in a world where people have their phones in their hands at any given occasion and therefore, you could make use of the situation and save a lot of money in the process.
While doing so however, it is important for you to allocate a few special people who will be in charge of taking pictures just in case your other guests do not manage to capture any great picture or in case their batteries die in the process. Ask about ten of your closest friends to be in charge of taking pictures so that you have a guarantee of great pictures at the end of your big day.
Is The Natural Look Always Better?


3-Alvin Wilfred McHugh was born on 3 Mar 1897 in Ulverstone, Tasmania, died on 4 Sep 1916 in World War 1 at Mouquet Farm, Pozieres, France at age 19, and was buried in Villers-Bretonneux, Departement de la Somme, Picardie, France.
Private Alwyn McHugh, of Devonport, whose death in action in France was announced in the 'Advocate' yesterday exhibited the truly patriotic spirit. As soon as he passed through the Senior Cadets into the Militia, he enlisted for active service, and sailed with the 7th reinforcements in October last; after a few months in Egypt he landed in France in June, where he has made the supreme sacrifice. His elder brother, Andrew, was a member of the first contingent, and served in Gallipoli, being invalided to England, where he was seen by Sir John McCall Agent-General, who advised his parents of his condition. He had been in France for some months and according to the last letters received, the brothers had not had the opportunity to meet each other.


Twitter - have you got it?
If you've been reading this series of Twitter 'how to' posts, and you have started using Twitter in the process, I'm guessing you will quickly have picked it up and worked out what's so good about it by now.
I know there were a few people in my Twitter Surgery at the Social Media Exchange in January that created Twitter accounts either during or after the session, and they seemed to have the hang of it within a day or two.
So, if it's so simple, why did I start this series on Twitter?
Because so many people were telling me they didn't 'get it', and so many people are still telling me that. In the same breath, though, they are keen to find out why I use it, what I use it for, and why I encourage charities to adopt it - along with other social media. A lot of them are people that run, or work at, PR, fundraising and marketing agencies, too, which I find surprising.
Almost everywhere I go someone is talking about Twitter. At a concert I went to the other night, there was a couple in the seats behind me talking about it during the interval and, on the tube on Friday night, another couple in my carriage were talking about how they'd thought Twitter was a waste of time until recently, when it started to get a lot of press. Both sets of couples were agency types, talking about how they wanted to understand Twitter more, so they could 'leverage' it for their clients and incorporate it into their digital strategies.
However, it's not surprising that so many people still think using Twitter is pointless. There is a lot of misinformation around about it and many people prepared to express an opinion about it, profess to use or understand it - not wanting to appear behind the times - that either haven't even set up a profile at all, have posted once or twice and got little from the experience, or have a profile because they think they should be seen to have one, but only post once in a blue moon for appearance's sake.
I've been neglecting my blog of late, and there are all sorts of things stacking up in my head that I've been wanting to post about. For now, here's something that caught my eye this morning.
I noticed that TripAdvisor is donating $1 million to charity and has nominated five organisations that it will split the amount between, 'as determined by the percentage of total votes that each charity receives' from visitors to its site.
You can vote for either, Save the Children, Medecins Sans Frontieres, National Geographic Society, The Nature Conservancy or Conservation International.
Once you have voted, if you log back in, you can go back and check TripAdvisor Causes to get an update on what percentage of the overall vote each charity has received -- A nice touch.
You also get the opportunity to invite others to add their vote by using a neat little dashboard with links to Delicious, StumbleUpon, Facebook, and a function that allows you to pull up to 50 of your contacts in from whichever web-based email you use. Easy!
I couldn't help thinking how clever TripAdvisor is to come up with a CSR offering so well aligned with their user-generated model, and was impressed at how straightforward they have made it for people to share the message (which, of course, is in their interests, since it drives traffic to their site). Still, it's something a lot of non-profit organisations could learn from.
I think it's a bit of a shame that there aren't clear links from TripAdvisor to any of the charities' home pages -- in some cases no links at all! -- which you would have thought Tripadvisor might have been kind enough to promote and those organisations would have pushed for. It smacks a little of self-interest on TripAdvisor's part; wanting to keep traffic within their site, or perhaps it's just an oversight?
Is this the tipping point for UK charities' adoption of social media?
However, as things turned out, I was needed at my desk more and I was pipped to the post by Jon Waddingham from Just Giving. The considerable upside of this was that I was able to keep track of some of the buzz from this year's Convention by following Jon's tweets, even though I wasn't able to be there. It was the next best thing – thanks again, Jon.
What I was really interested in – if you hadn't guessed – was whether the speakers this year would be tuned into social media, whether the charities and agencies would be presenting any useful insights into how they are using them, what they have learned and what's been working for them.
Tom Mansel-Pleydell, head of client services at Just Giving, whose session was entitled, 'Social Media: Join in or miss out'.
You can visit Jon's profile for more. And you can compare and contrast with this piece published shortly afterwards on the Guardian website. Both provide some very useful insights.
And I hope it's not lost on those who are still reluctant, that this post would not exist without social media, and people using them to connect around a common interest.
What, you mean you don't give to charity???
I found myself suggesting to a friend recently that supporting good causes was undergoing a huge change; that it's becoming almost fashionable to support a charity and more and more people are doing it because they think everyone else is, and it's the thing to do.
I think social media is the big lever in this, because it gives people a platform to show others what they're doing, where they're going, who with, what they did, how much fun they had doing it; it gives us all a way to share more about ourselves with the people we've got a connection with. You could argue that there's an element of competitiveness about some of what people share, but it's also hugely positive -- because it gives us a deeper understanding about the people we know, through this series of windows into their lives and their psyches, to an extent we never had in the past.
We find out that a business associate we've known for years takes the most beautiful photographs, that a friend we haven't seen for a while is backpacking solo in Japan, that one of our old clients is an aficionado of facial hair, that an old house mate now has two gorgeous children and two enormous pedigree cats, that someone we went to school with likes Jon Spencer Blues Explosion too. And we find out which charities they all support -- because they invite us to join the group or campaign they've set up for the cause on Facebook.
There's something highly tribal about this –- which is effectively what fashion is all about –- and I think the power it has to spread ideas and information is going make charity giving 'mainstream' in a way it has never quite been previously.
I realise this could be perceived as a slightly tasteless thing to say, when so many charities are raising money for deeply serious causes, but I'd rather people gave money to charity than spend it on Louis Vuitton handbags any day -– so shoot me.
Social networking - an income generator?
I've been thinking a lot about this subject recently, and I saw an article today from the States that has inspired me to post.
It's always interesting to hear how charities are beginning to tap into the potential of online social networks, because it's such early days yet, and there's still not much evidence around of this type of engagement with charities converting into income on any scale. However, I think organisations need to change their perceptions about this anyway.
Debates seem to be raging all over the place – particularly online – about whether digital media will replace print media (most people are focusing, as usual, on direct mail), and whether charities should 'switch their budgets' from one to the other. I've also heard budget-holders say that they're considering digital because it's 'a cheaper medium to reach more people' than direct mail. This all seems to be in the context of recruiting financial supporters.
Social media are relationship-building tools that will help organisations engage with individuals who might support their mission in many ways; not necessarily financial.
Time will tell, but my hunch is that social media offer excellent channels to connect with new audiences, increase awareness, recruit campaigners and advocates (remember that a lot of these people have proactively joined up around your cause – they're online activists), and create a new kind of self-selecting prospect pool, from which a percentage will convert to financial support if you engage them in the right way.


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Erika Stüven ist eine ehemalige deutsche Handballspielerin.

Werdegang
Der Torhüterin gelang 1989 mit dem TuS Alstertal der Aufstieg in die Bundesliga. Im Anschluss an die Saison 1989/90, in der der Bundesliga-Klassenerhalt verfehlt wurde, beendete sie zunächst ihre Laufbahn, blieb dem TuS Alstertal aber als Kassenwartin der Handballabteilung treu. Später spielte sie wieder in der 2. Bundesliga für den Hamburger Verein.

Einzelnachweise

Handballspieler (SC Alstertal-Langenhorn)
Handballtorwart (Deutschland)
Deutscher
Geboren im 20. Jahrhundert
Frau


With over 3.7 million direct jobs the IT sector is the largest private sector employer in India. There are 16,000 IT firms in India and with an increasing number of start-ups popping up, the Indian market offers cost-effectiveness, high quality, great reliability, quick deliveries and the use of state-of-the-art technologies in the IT Industry. India already is a preferred IT destination for many companies and various international organizations have set up offices in India. This has led to a great increase in Foreign Direct Investments to India. Between 2000 and 2016, the IT sector ranked 4th in total FDI inflow in the country.
With approximately 67% of the global market, India is the world's largest sourcing destination for the IT Industry. More importantly, the industry has led the economic transformation of the country and has helped India to make its mark on the global economy map.
Sales in India – what is my best India market-entry strategy?
With the umpteen customizations, dedication and process orientation to Ivoclar, Maier+Vidorno has proved to us that they are perfect partners in Ivoclar Vivadent's success in India.
Selling German quality products in India is rewarding and challenging at the same time. The team of Maier+Vidorno supports our goal to deliver quality – in time.
Manish Sahay, Country Manager, Leuze electronic Pvt. Ltd.


Join the Grimes Lions Club at the annual Grimes Easter Eggstravaganza on March 31, 2018. The Lions will be serving mini donuts, french toast sticks and pancake wrapped sausage links on a stick. A free will offering will be collected. The event will be held at the Grimes Community Complex at 410 SE Main Street, Grimes, in the heart of the Governors District from 9:00 until 12:00. The Easter egg hunt begins at 10:40.


Other big companies should emulate the tech giant's focus on helping suppliers get there, too.
Once Hawaii publicized its goal to be powered entirely by renewable energy by 2045, the state's options to get there expanded greatly. "We saw a slew of different solutions that can help Hawaii get to its renewables goal," said Luis Salaveria, director of the Hawaii Department of Business, Economic Development and Tourism (DBEDT). That includes the renewables mix of hydro, wind and solar, as well as the technology to get power on the grid.
Why they're listening to customers more closely than ever to get there.


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En la actualidad, la comunicación multimodal es un campo en el cual se está investigando y se ha producido frontera para las comunicaciones. La dificultad no  en cómo adaptar todos estos datos e información de manera que no es
 interfaz electrónica los pueda interpretar y nos permita interactuar con ella mediante esta comunicación.

Respecto a los elementos citados anteriormente que influyen en esta comunicación podemos decir que: apenas una pequeña parte de estos instrumentos comunicativos se ha estudiado a fondo, mientras que la lingüística hace 2000 años atrás que se estudia. La lingüística ha estudiado las reglas que gobiernan el comportamiento verbal, pero casi no se han investigado el resto de las modalidades.

Por todo esto podemos decir que la interactividad y la comunicación multimodal es una apuesta de futuro que ya se está desarrollando en el presente.

Impacto de la comunicación multimodal en educación

Existen diversos modos de comunicación que se articulan entre sí para dar como resultado la creación de significados derivados del discurso de un emisor. En el ámbito educativo, este discurso multimodal adquiere relevancia en el espacio áulico ya que es ahí donde se da el mayor intercambio de palabras, gestos, posturas, esquemas, ilustraciones, etc., en relación con un objeto determinado de estudio entre el maestro y sus alumnos.

Los conceptos que se estudian en las materias científicas son contenidos muy bien estructurados, por lo que resulta relevante estudiar los modos de comunicación más apropiados para construir un significado común en torno al objeto de estudio. Conceptos como "el ciclo del agua", "la fotosíntesis", "la reproducción asexual de las plantas", etc., son ejemplo de ello. Se habla de una construcción en común porque intervienen en ella los alumnos como el docente para llegar a cierto consenso en la definición de cierto concepto. Es decir, se puede hablar de una dimensión social en los hechos de la comprensión científica de un objeto en particular o de una construcción social del aprendizaje.

Pero, ¿cuáles son estos modos particulares de comunicación o modos semióticos de los que estamos hablando? "Procesadores de textos, aplicación de dibujo o diseño, programas de animación (Citados por Márquez, 2003) y otros más que van surgiendo gracias al desarrollo de la misma tecnología. Además de lenguaje oral y escrito que tradicionalmente se ha venido utilizando en la práctica educativa.
Más de alguno de los anteriores modos y otros que no se han mencionado tienen lugar en el aula; es decir, que son utilizados por el docente en su afán de enseñar y por los alumnos, en su tarea de aprender.

Hoy en día existe la necesidad de utilizar nuevas formas para que los alumnos se apropien de los conocimientos propiciando el empleo de las TICs en el diseño de ambientes de aprendizaje.
En la actualidad es fundamental que el docente provoque  la participación activa de los estudiantes durante su proceso de aprendizaje y solo se logrará utilizando diversos dispositivos donde se utilice la comunicación auditiva, visual, táctil y gesticular, con la posibilidad de realizar dicha interacción desde cualquier lugar y en cualquier tiempo.

Nos vamos acercando a la contribución más importante de esta multiplicidad de formas de comunicar los contenidos de aprendizaje. En la medida que se elijan las mejores formas comunicativas, las más variadas, las más pertinentes, el nivel de transferencia y apropiación de ciertos contenidos se acrecentará en la figura del docente como de los alumnos, lo cual tiene importantes implicaciones para obtener mejores resultados en los procesos de enseñanza y aprendizaje.

Impacto de la comunicación multimodal dentro de una sesión de clase

La incorporación de la comunicación multimodal en la educación presenta numerosas ventajas en el proceso de enseñanza-aprendizaje, su aplicación exige una preparación especial por parte de docentes y estudiantes para poder aprovecharla adecuadamente, exigiendo estrategias, modificaciones en su planeación, diversidad de materiales para presentar la información y una adecuada incorporación de las TIC que propicien la búsqueda y generación de conocimientos que permitan obtener el mayor beneficio de la labor docente y de los aprendizajes de los alumnos.

La incorporación de las TIC en la enseñanza influye en la presentación de la información en clase y exige cambios en la planeación y tratamiento didáctico, además de que facilitan la actualización rápida de la información y la posibilidad de poder complementarla entre diversos medios didácticos enmarcados en la clase no presencial como complemento de la clase presencial, finalmente es necesario lograr en los docentes la capacitación necesaria para la adecuada valoración y explotación de las TIC.

Lenguajes de funcionamiento
Los lenguajes utilizados como estándar para descifrar los diferentes modos de comunicación son:

 VoiceXML es un lenguaje de etiquetado que permite crear diálogos con los que se puede interactuar escuchando comandos hablados, controlables a través de entradas de voz. VoiceXML se encarga de convertir habla en texto y para ello utiliza, entre otros mecanismos; SRGS (Gramática de Reconocimiento del Habla).
 SRGS tiene como función principal, permitir que una aplicación de voz indique a un reconocedor, qué es lo que tiene que escuchar, es decir, palabras, modelos en los que estas palabras surgen, lenguaje hablado de cada palabra, etc.
 SSML, lenguaje de marcado de Síntesis del Habla, basado en XML, forma parte del proceso de salida de información y funciona como componente de conversión ayudando a generar habla sintética. Este lenguaje tiene como principal objetivo ofrecer a los autores de contenido sintetizable un camino estándar para controlar aspectos del habla como pueden ser la pronunciación, volumen, tono y velocidad, mejorando así la calidad del contenido sintetizado.
 EMMA es un lenguaje utilizado para el intercambio de datos en sistemas de administración de interacción multimodal. Es una especie de lenguaje común utilizado en la comunicación entre componentes de un sistema multimodal, cuyo objetivo es integrar la entrada de datos procedente de los usuarios desde diferentes recursos, y darle forma para ser procesada en una representación única que será a su vez procesada por componentes avanzados de procesamiento de información.

Ejemplificación
Un usuario señala un lugar en un mapa y dice: ¿cómo se llama este sitio? El sistema de interacción multimodal responde diciendo La Plaza de Europa, Gijón, Principado de Asturias, España, mostrando en el mapa el texto siguiente La Plaza de Europa, Gijón, Asturias, España. Ahora veamos las acciones llevadas a cabo por los componentes que intervienen en dicha acción:

Usuario: Señala un lugar en el mapa y dice,¿Cómo se llama este sitio?
Componente de reconocimiento del habla: Reconoce las palabras ¿Cómo se llama este sitio?
Componente de reconocimiento del ratón: Reconoce las coordenadas x-y que el usuario ha señalado en el mapa.
Componente de interpretación del habla: Convierte las palabras ¿Cómo se llama este sitio? en una notación interna.
Componente de interpretación de indicación: Convierte las coordenadas x-y del lugar indicado por el usuario en una notación interna.
Componente de integración: Integra la notación interna de las palabras ¿Cómo se llama este sitio?, con la notación interna de las coordenadas x-y.
Componente del administrador de la interacción: Almacena la notación interna en el objeto de la sesión. Convierte la petición en una petición de una base de datos, envía la petición a un sistema de administración de peticiones, la cual devolverá el valor La Plaza de Europa, Gijón, Asturias, España. Añade la respuesta a la notación interna en el objeto de sesión. El administrador de la interacción convierte la respuesta en una notación interna y envía la respuesta al componente de generación.
Componente de generación: Accede al componente de entorno para determinar que los modelos de voz gráficos están disponibles. Decide presentar el resultado como dos modelos complementarios, voz y gráficos. El componente de generación envía una notación interna representando La Plaza de Europa, Gijón, Asturias, España al componente de estilo de voz, y envía una notación interna al componente de estilo de gráficos, mostrando la ubicación de La Plaza de Europa.
Componente de estilo de voz: Convierte en SSML la notación interna que representa La Plaza de Europa, Gijón, Asturias, España.
Componente de estilo de gráficos: Convierte la notación interna que representa la ubicación en un mapa de La Plaza de Europa, Gijón, Asturias, España en una notación HTML.
Componente de conversión de voz: Convierte la notación SSML en voz acústica para que el usuario pueda oírla.
Componente de estilo de gráficos: Convierte la notación HTML en gráficos visuales para que el usuario pueda verlos.

Véase también
Reconocimiento del Habla

Telecomunicaciones


text:
Prospective randomized trial to assess effects of continuing hormone therapy on cerebral function in postmenopausal women at risk for dementia. PloS one Rasgon, N. L., Geist, C. L., Kenna, H. A., Wroolie, T. E., Williams, K. E., Silverman, D. H. 2014; 9 (3)
The objective of this study was to examine the effects of estrogen-based hormone therapy (HT) on regional cerebral metabolism in postmenopausal women (mean age?=?58, SD?=?5) at risk for development of dementia. The prospective clinical trial design included pre- and post-intervention neuroimaging of women randomized to continue (HT+) or discontinue (HT-) therapy following an average of 10 years of use. The primary outcome measure was change in brain metabolism during the subsequent two years, as assessed with fluorodeoxyglucose-18 positron emission tomography (FDG-PET). Longitudinal FDG-PET data were available for 45 study completers. Results showed that women randomized to continue HT experienced relative preservation of frontal and parietal cortical metabolism, compared with women randomized to discontinue HT. Women who discontinued 17-ß estradiol (17ßE)-based HT, as well as women who continued conjugated equine estrogen (CEE)-based HT, exhibited significant decline in metabolism of the precuneus/posterior cingulate cortical (PCC) area. Significant decline in PCC metabolism was additionally seen in women taking concurrent progestins (with either 17ßE or CEE). Together, these findings suggest that among postmenopausal subjects at risk for developing dementia, regional cerebral cortical metabolism is relatively preserved for at least two years in women randomized to continue HT, compared with women randomized to discontinue HT. In addition, continuing unopposed 17ßE therapy is associated specifically with preservation of metabolism in PCC, known to undergo the most significant decline in the earliest stages of Alzheimer's disease.ClinicalTrials.gov NCT00097058.
View details for DOI 10.1371/journal.pone.0089095


text:
Peropteryx pallidoptera és una espècie de ratpenat de la família dels embal·lonúrids. Viu a l'Equador i el Perú.

Descripció

Dimensions
És un ratpenat de petites dimensions, amb una llargada total de 57–67 mm, els avantbraços de 39–43 mm, la cua d'11–15 mm, les potes de 8–10 mm, les orelles de 15–17 mm i un pes de fins a 6 g.

Descripció
El pelatge és llarg. Les parts dorsals són marrons, amb la base dels pèls més clara, mentre que les parts ventrals són lleugerament més clares. El musell és puntegut i manca de pèls. El front és alt. Les orelles són triangulars, amb l'extremitat arrodonida, marrons, cobertes de plecs cutanis a la superfície interna del pavelló auricular i ben separades entre si. El tragus és curt i amb l'extremitat arrodonida, mentre que l'antitragus és semicircular, llarg i s'estén cap endavant gairebé fins a l'angle posterior de la boca. Les membranes alars són de color marró clar, semitransparents i acoblades posteriorment al llarg del maluc. Un sac glandular poc desenvolupat és present entre l'avantbraç i el primer metacarp, està disposada paral·lelament al cos, s'estén fins a la vora d'entrada alar i s'obre cap endavant. La cua és relativament llarga i sobresurt per l'uropatagi a aproximadament la meitat de la seva llargada. El calcani és llarg.

Biologia

Comportament
Viu a l'interior de coves als boscos.

Distribució i hàbitat
Aquesta espècie és difosa a l'Equador oriental, el Perú septentrional i l'estat brasiler de Pará.

Viu en boscos situats fins a 400 metres d'altitud.

Estat de conservació
Com que fou descoberta fa poc, l'estat de conservació d'aquesta espècie encara no ha estat avaluat.

Referències

Bibliografia

pallidoptera


In Welcome to the Big Leagues, I discuss some of the teachings from my former business coach, John Sorci. In the book, I refer to John as being the best business leader that I have worked for, and after you get to know him it's easy to see why. Having sustained a thriving business career for 30 years, John has mastered the game. He's recently retired but continues to live a fulfilling and meaningful life. The interview below combines questions that are both pre and post retirement. I hope that you enjoy gaining the perspective of this greater leader and business coach who has helped to guide me and many others.
Me: With more than 25 years of leadership experience, what advice would you give to the corporate rookies of today?
John: For starters, I think it's very important to have a passion for what you do. You should care about it and enjoy what you are doing. I also encourage rookies to spend time thinking about their careers. To this day, it still surprises me how many take it day to day and don't think about the long term. I believe that it is each person's responsibility to be the CEO of his or her career. It is also very important to know where you want to go and what you want to do. Without such awareness it will be difficult to surround yourself with the right people and learn from those who could help you get there.
Me: Despite your hectic workload and busy travel schedule, you always spent much of your time coaching or mentoring. Why was this a priority?
John: We are all hired to get results. As a manager, growth and development of the people within the organization is critical, as we are each only as good as the team we lead. The best way that I knew how to make the team better is by offering challenging assignments and coaching for success; which is why I remained committed to such employee development programs. I also found it equally rewarding to help those who are eager to better themselves. It was sort of my way of giving something back.
Me: What do you believe are the key attributes of a good coach and are there any parallels to being a good parent?
John: The key attributes of a good coach are to know the strengths and weaknesses of the people or players on your team. With this knowledge, a coach can place each team member in a job that puts them in the best position to win.
I also believe that a good coach needs to care about people and be willing to dish out tough love when needed; which is very similar to what you do as a parent. Having raised four children and coached 18 years of baseball, I consider the attributes of a good Parent, Manager and Sports Coach to be very similar. Attributes like integrity, passion, patience, dedication and commitment have helped me to experience success in each arena.
Me: Do you still find yourself learning today? If so, what techniques do you use to stay current?
John: Absolutely. I am always learning or trying to re-sharpen the saw. If not, one will quickly become obsolete. I complete all of the assignments in my coaching program but do most of my learning through reading and observation. I have learned a lot throughout my career by watching how others handle things. Observing what not to do can be equally as important as learning what to do.
Unfortunately, there is never enough time to read everything that I would like. In fact, I purchased a speed reading program to help me tackle more but haven't found the time to get through it.
Me: Are your views of leadership today the same as when you started or has it been an evolution?
John: The basics of leadership have remained the same. Have a vision and clearly communicate that vision in such a way that others willingly follow.
In today's world, the speed of change is drastically different. Communication is 24/7 and change is constant. Thirty years ago we didn't have any of the tools that we do today. No internet, email or voice mail. This made it extremely difficult to direct people out of their comfort zones or to adopt new technologies.
The coaching I did in my early 30s was also perceived differently. Employees were fresh out of school and viewed me more as a peer. Today, I'm more like a father figure. I have a higher position and, hopefully, more wisdom acquired through the school of hard knocks. Therefore, employees are more willing to accept what I have to say.
It is very rewarding to see people that I coach develop. However, motivation has always been and will always be an internal engine. They have to do it. As a leader you have to walk the talk and hope they use some of your techniques.
Me: How have you managed family/work life balance throughout your career?
John: Each person needs to have their own set of values that they adhere to. I personally work to live rather than live to work. My career has always been important to me but never as important as my family. For 18 years, I coached baseball; which meant that I would have to leave work at 3:30pm two days per week. I'd make up for it in other ways. But the commitment to my children was well worth the sacrifice. I'm proud to say that I never missed any of my kid's games or other big events in their life while being a parent.
When people are out of balance, they're unhappy. My perception of success has always been on the balance as opposed to earning more money.
Me: As a leader, you tell it like it is and went above and beyond the call of duty by hosting general Q&A sessions to keep all employees better informed. Did it bother you when turnout or engagement was low?
John: To be honest with you, I was very frustrated by the low participation level. People were constantly saying that they never knew what's going on in the company. So I made myself available twice per quarter through Q&As and All Hands meetings. I also did my homework in advance of each meeting to be sure that I could address most issues. Unfortunately, I would only receive three to four questions, usually from the same people, in each meeting. I also felt like I had to bribe employees with a free lunch to attend in person! For those who would call in on the phone, I've asked that they email me questions in advance but that never worked either. I thought about no longer hosting those meetings, but then wanted to remain true to making myself available.
I was always honest about results; most topics were usually fair game and I addressed the challenging issues. I am not sure what more I could have done to get the team engaged.
Me: What do you enjoy most when you are outside of the office?
John: Sports. In particular, Major League Baseball and the NFL. Family events. We have six grandchildren. I also enjoy flying (John has a private pilot's license) but I don't get to do that nearly as much as I would like. When it happens, my wife and I will typically get out for a day trip. I also enjoy leisure travel. Not business! The best vacation I ever had was 10 years ago in Rome. Seeing the Vatican, the Sistine Chapel and the Roman Ruins was a big treat for me, as well as enjoying the amazing food.
Me: Now that you are retired can you say that you planned well for this period of your life?
John: Yes, after 2.5 years now, I am please with how it is working out. Planning for retirement is typically not something high on most people's list until they enter their 50's and that was true of myself. Like most people, I wanted to keep the same lifestyle and shift my priorities to things I enjoy (family, travel, reading, flying, ball games, etc.) and not worry about making enough money to support it. In addition, good health is the first requirement for a happy retirement so one can pursue their passions and I am fortunate to have that as well (thanks to good genes and not necessarily my own efforts).
Me: Looking back at your career: What do you miss most and would you have done anything differently?
John: I miss the people and personal relationships the most. Although I keep up with a few people via email and an occasional lunch, they and I have moved on so we have less in common. I sometimes miss the intellectual challenge and working with suppliers. To be brutally honest, I miss being in a leadership position at times. I don't miss the 40 mile commute, business travel or the relationships with some difficult people.
Looking back, I stayed at the same company for too long mainly for financial reasons (stock appreciation) and should have moved on to a position of increased responsibility 5-7 years before I retired with more customer interaction like I had at previous companies. I enjoyed having direct responsibility vs. running a number of support groups like I did in my last role.
A few years ago, as part of an employee coaching program I hosted a session on the book Mastery by George Leonard. Despite the fact that Mastery was written more than 20 years ago, I found its teachings to be timeless. I strongly recommend this read for anyone with the dedication to pursue this extremely disciplined path. I reference some of Leonard's material in Chapter 6 of Welcome to the Big Leagues, as the true advocates of mastery will never find themselves in a Slump.
You can find free links to download George Leonard's book online or purchase a physical copy on Amazon. I would post the free link here but do not feel right about giving away an author's copyrighted material. Instead, I will give you a free copy of the slide deck I created on the book to help keep the learning fun. Enjoy!
At the end of Welcome to the Big Leagues, I recommend 5 additional books to read. These will help to keep the learning streak alive and broaden your perspective on the world, and your role in it. I do not mention When Science Goes Wrong by Simon LeVay, but I will do so now, as it is an easy and enthralling read. In business, quality is everything. Simon's book is full of short, but true examples of great catastrophes and errors made by some of the most educated, if not brilliant. As an individual and as a species, we have all been known to face extreme setbacks on the road to success. The more we learn now, the better chance we have of dodging such bullets in the future.
In Chapter 7, The Stretch, of Welcome to the Big Leagues, I write about wellbeing and one of the key areas focuses on the Physical. You may be thinking "why would a business book take on the subject of Physical Wellbeing"? My answer: Welcome to the Big Leagues is much more than just an ordinary business book. My goal was to help the rookie crowd to avoid the drastic mistakes that I and many others have made. These errors go beyond the office, as trouble in one area of our lives impairs others.
There are many business veterans who teeter on the line of success. This group will also benefit from reading Welcome to the Big Leagues as a refresher.
As a person who almost always worked hard to stay physically fit, there were two periods in my life where I let the wheels fall off. As you may have guessed, the first occasion was as a corporate rookie. Consumed by work, I gained approximately 25 lbs. within a year.
The embedded pictures display my repeated battle between good and poor health. In Picture A, I was a newbie to the corporate world who just started to put on a few extra pounds; which didn't concern me. Picture B, was taken only one year later. During this time, I was in very poor health and shape. My workout regimen had been abandoned and it was not uncommon for me to binge at fast food restaurants four times per week. I felt and looked as though this lifestyle had aged me by at least 10 years.
Picture C was taken roughly two years after picture B. I had been living a much healthier lifestyle. Exercise was part of my daily routine and I made very smart food choices. My youth had been restored and I was in excellent health. You are what you eat and it showed.
Picture D was taken only one year after picture C. Those additional 25lbs returned home once again! Only this time, heart complications came with it. After a couple of poor EKGs, my newly sought cardiologist prescribed blood pressure medication.
The good news is that I returned to good health once again. I lost the extra weight and committed myself to a steady exercise routine. I have completed three full marathons after Picture D was taken and will complete more in the future.
Like all topics in this book, the areas of Wellbeing are very important to me. My stories and remedies were shared to help you. In order to effectively spread knowledge, I revealed and exposed more about myself than I ever thought that I would. As a leader who tells it like it is and leads by example, this really doesn't surprise me. Help to spread the good word and pick up your copy of Welcome to the Big Leagues on 4/12.


We encourage anyone (see guidelines below) who has a desire to participate in the Children and Youth Ministries to become involved. There are numerous opportunities to teach, help, and support these programs.
All volunteers in Children and Youth Ministries must go through our Safe Sanctuaries process. Volunteers must have an active relationship with St. John's for over six months. In addition, a Criminal Record Check, Child Abuse Clearance and FBI Fingerprinting must be obtained. Volunteers must interview with staff, provide references and participate in our training program. For more information, please contact David Bigam, Director of Children and Youth Ministries, at 215-357-6998. To begin the process click the link below.


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China's currency is having an even better year than the US dollar. Here's why
Hong Kong (CNN Business)China is grappling with a slowing economy, yet its currency has rarely been stronger. The yuan is also outperforming the US dollar this year even as the Fed prepares to hike interest rates. So what gives?
The Chinese currency has soared more than 8% in 2021, according to an index that tracks the yuan's performance against 24 other currencies. Based on that gauge — the CFETS RMB Index — it is just 0.26% short of its previous record high set in November 2015.
The yuan has also gained ground on the dollar. The yuan has risen between 2.4% and 2.8% this year against the greenback — depending on whether it trades in China or offshore. Both versions are now at their highest levels against the dollar in three years or more. The offshore rate currently trades at 6.34 yuan per dollar, a level not seen since May 2018.
Headed into December, the yuan's gain this year
Headed into December, the yuan's gain this year was "the best in the world," said Marc Chandler, managing director for Bannockburn Global Forex, an Ohio-based capital markets trading firm.
Booming exports and hot money chasing comparatively juicy returns on Chinese government bonds are behind the surge "despite weaker economic growth," according to Becky Liu, head of China macro strategy at Standard Chartered Bank.
The currency's strong performance could continue into 2022, even as China's economy struggles with factory inflation, a major slowdown in real estate, and an ongoing regulatory crackdown targeting its private sector.
Liu expects the yuan to strengthen to 6.3 per dollar in the first few months of next year. Analysts at Goldman Sachs suggest the same could happen in the first half of 2022, for similar reasons. (In 2014, the offshore yuan touched nearly 6.01 against the dollar, its highest level since China conducted a landmark reevaluation of its currency in 2005.)
There are upsides to this trend. The stronger the yuan, the more likely central banks are to keep a lot of the currency in reserve, promoting its global use. It could also help to make imports cheaper and curb high inflation. China buys a lot of commodities that are priced in dollars.
But there's a pretty big downside if the currency appreciates too rapidly. For as strong as Chinese exports are right now, a pricier currency could also cause those exports to become less competitive abroad. Given how vital trade has been to China's economy, that could threaten an already fragile recovery.
Strong exports
China's economy has been hit in recent months by shipping disruptions and a deepening property crisis. A severe energy crunch, which has since eased, also contributed to the economy expanding at its weakest rate in a year last quarter.
Even so, Chinese exports have held up well. Shipments from China reached $325.5 billion in November, a 22% jump over the year before, according to government statistics released Tuesday. Exports through the first 11 months of the year have surged 31% to more than $3 trillion — more than all of 2020.
Analysts have attributed that performance mainly to strengthening demand for Chinese goods as the world recovers from the coronavirus pandemic. China, which has taken a zero-tolerance approach to Covid-19, has also largely avoided the disruption suffered by rival exporters, such as Vietnam and Indonesia, because of coronavirus outbreaks.
The main reason for the yuan's surge is the amount of money flowing into China, largely thanks to surging exports, said Larry Hu, head of China economics at Macquarie Group.
He said it's likely that exports will remain strong even as the world responds to the Omicron variant of the coronavirus, "if the experience from the Delta variant this summer is any guide."
Analysts at Standard Chartered also said last week that China's exports could get a boost as the United States increases shipping capacity. They pointed out in a research note that constraints on such capacity should ease as more US ports increase operations.
Betting big on Chinese bonds
Another reason for the yuan's rally, according to analysts, is the amount of international enthusiasm for Chinese bonds.
The value of yuan-denominated bonds held by international investors rose for the eighth straight month in November to hit 3.9 trillion yuan ($620 billion), according to the People's Bank of China.
Global investments pouring into Chinese bonds accelerated after FTSE Russell, the global index provider, in October added Chinese government bonds to its flagship World Government Bond Index. That's one of the world's most widely used global bond benchmarks.
Analysts at ANZ expect China's inclusion in the index to bring around $130 billion worth of investment to Chinese government bonds over the next three years. They also estimated that foreign investors will own 4 trillion yuan ($625 billion) worth of China's onshore bonds by the end of this year.
"Concerns over downside risks to China's near-term growth outlook will not deter foreign investors from increasing their allocation to Chinese assets, in our view, " the analysts wrote in a research report last month.
Global investors are chasing "attractive" returns from Chinese government bonds, they added. China right now offers a 10-year yield of 2.9%, compared to the US Treasury 10-year yield of 1.44%. The ANZ analysts expected those bonds to keep their appeal, helped by the low volatility of the yuan, which still does not trade entirely free of government intervention.
Stabilizing the yuan's rise
And Beijing may yet intervene to brake the yuan's rapid appreciation.
The People's Bank of China announced Thursday it would raise the foreign exchange reserve requirement ratio to 9% from 7% — the second hike in the ratio this year. The move will force Chinese financial institutions to keep more foreign money in reserve, and has been widely interpreted as an attempt to temper the yuan's rally.
"This is one of the strongest signals" that the central bank is uncomfortable with the yuan's pace of appreciation, wrote Gaurav Garg and Philip Yin, analysts for Citi, in a report on Friday.
The central bank had already warned last month that financial institutions and companies should refrain from making "speculative" bets about the yuan. Analysts said regulators are concerned that if the yuan is too strong, it will hurt the competitiveness of Chinese goods around the world. Financial markets could also be rattled by a rapid influx of capital if the currency appreciates too quickly.
"It is desirable for the [yuan] to stay largely stable [for] the Chinese authorities, in our view," said Liu from Standard Chartered.
Still, Liu expected that the odds remain low that China would deploy "heavy-handed direct intervention," such as directly buying dollars and selling yuan.
A US interest rate hike or two may also take some of the heat out of the yuan, as China heads in the opposite direction on monetary policy in a bid to boost growth.
"We still expect further gains in the yuan, but at a much more gradual pace," Goldman Sachs analysts wrote in a research report last month, noting that China's "key trading partners" have started to tighten policies.


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September 5, 2012 / 5:43 PM / 7 years ago
Kyrgyzstan MPs elect new prime minister to avert turmoil
Olga Dzyubenko
BISHKEK (Reuters) - Kyrgyzstan's divided parliament elected a neutral candidate as prime minister on Wednesday in an attempt to avert political turmoil and revive the shrinking economy in the volatile Central Asian country.
Head of the presidential administration Zhantoro Satybaldiyev (bottom) attends a parliamentary session in Bishkek, September 5, 2012. REUTERS/Vladimir Pirogov
Zhantoro Satybaldiyev, the 56-year-old head of the presidential administration, warned deputies in the five-party parliament that his new cabinet would take "unpopular measures" to fight corruption and restore growth.
"I have never promised to replenish the budget," he said before securing 111 of 113 votes cast in a late-night vote in parliament. "We will have to cut budget spending, and we will also have to improve tax administration."
Kyrgyzstan, a predominantly Muslim nation of 5.5 million which borders China, lies on a drug trafficking route out of Afghanistan and hosts both U.S. and Russian military air bases.
The mountainous nation, one of the poorest of the 15 former Soviet states, has seen two presidents deposed by violent revolts since 2005 and was rocked by ethnic riots in June 2010, when around 500 people were killed.
A new model of parliamentary democracy, backed by the United States but viewed with suspicion by former imperial master Russia, makes parliament the main decision-making body and gives the prime minister more powers than the president.
"In the name of Kyrgyzstan and development, I call on everyone to work in peace and harmony," said Satybaldiyev, who headed the state body set up to rebuild Osh and Jalalabad, the southern cities worst hit by the 2010 unrest.
Three of the five parties in parliament agreed this week to form a coalition government, two weeks after the previous administration collapsed under the strain of graft accusations against then-Prime Minister Omurbek Babanov.
"Until stability is established, we will not be able to attract large-scale foreign investment," said Satybaldiyev, whose previous jobs include transport minister and governor of Osh region. "We need to lead a fight against corruption."
Babanov resigned last weekend after his Respublika party was frozen out of the three-party ruling coalition spearheaded by the Social-Democratic Party of Kyrgyzstan.
His election as prime minister last December had been a glimpse of hope for many in the impoverished country, signalling the conclusion of an 18-month drive to build the first parliamentary democracy in otherwise authoritarian Central Asia.
But the Kyrgyz economy, which depends heavily on production from Canadian miner Centerra Gold's Kumtor mine, was dealt a heavy blow this year as output dropped, contributing to a 5 percentage-point contraction in January-July GDP.
Remittances from migrant Kyrgyz workers also help keep the economy afloat. Per capita GDP is less than a tenth of that in oil-rich neighbour Kazakhstan.
Withdrawing from the previous coalition on August 22, deputies from the Ata-Meken party - which also sits in the new coalition - warned that Kyrgyzstan risked defaulting on its $2.8 billion foreign debt.
The only party outside the previous coalition, Ata Zhurt, enjoys strong support among Kyrgyz nationalists, particularly in the poorer south. It won marginally more seats than any other single party in the last parliamentary election in October 2010.
Writing by Dmitry Solovyov and Robin Paxton; Editing by Michael Roddy


From now until December, the Government wants to hear from as many people as possible to help ensure New Zealand is the best place to be a child.
Oat the Goat | Oti te Nanekoti has won the Interactive Purple Pin and Moving Image Purple Pin at the Design Institute of New Zealand awards.
A new report released today by the Ministry of Education reflects the Ministry's ongoing commitment to giving parents confidence in ECE.
We want to hear what you think is working well and what could be changed to improve early learning for all children from birth to 5 years old.
Outstanding education practices in early learning services and schools were celebrated at the PM's Education Excellence Awards ceremony held on 3 July 2018.


Join us Sunday, February 17 for 10:30 a.m. worship as we celebrate Baptist Women in Ministry Month of Preaching (formerly Martha Stearns Marshall Month of Preaching) by welcoming Minister Tamara Crutcher of First Baptist Church East Castle Street as our guest preacher. We will have special music from Castle Street musicians as well as our own Chancel Choir, so don't miss this special worship opportunity!
Tamara Crutcher serves as an associate minister at First Baptist Church in Murfreesboro, TN. She is a Lewisburg, TN native and received a Bachelor's of Sociology degree from Middle Tennessee State University in 2009. Currently, Tamara is pursuing her master's degree in Social Work. She is happily married to her high school sweetheart, Derrick Crutcher.
Mrs. Crutcher was licensed to preach at First Baptist Church in Murfreesboro, TN under the leadership of Pastor James M. McCarroll, Jr. She has a passion for sharing the gospel and helping women and at-risk youth lead lives on fire for the Lord. Currently, Mrs. Crutcher works behind the scenes in community mental health, is a published author, and is the founder of FIT Women of God—an online ministry designed to help women identify their strength in Christ and become faithful in the transitional spaces of life.
She approaches ministry and life with the mentality that God has brought her too far to hide in the back now. This approach has aided her in showing others how God can use them no matter where they are in life. Tamara's belief is that God never intended for us to navigate through this world alone, so His expectation is that we do life together.


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PK Women's Specialist Clinic
2 Tai Thong Crescent
Dr Tan Poh Kok is an obstetrician and gynaecologist with more than 15 years of experience. He was a Senior Consultant at the Department of Obstetrics and Gynaecology, Singapore General Hospital until he left in late 2011 to set up his own practice.
Dr Tan provides care for pregnant women and general gynaecological services. In 2005, the Ministry of Health sent him on a scholarship to undergo training in Melbourne, Australia in the subspecialty of Urogynaecology, which is his special interest. This sub-specialty is dedicated to the treatment of women with female pelvic floor disorders such as ... See more [ + ]post-natal (post-pregnancy) or post-menopausal womb prolapse and female urinary incontinence (involuntary urinary leakage).
Dr Tan has extensive experience in performing vaginal surgeries including vaginal hysterectomy for non-prolapse benign uterine conditions (such as uterine fibroids / adenomyosis) as well as pelvic floor reconstruction for womb prolapse. He is also well-versed in laparoscopic (key-hole) pelvic surgery for common gynaecological conditions (eg ovarian cysts and fibroids).
English, Hokkien, Mandarin
National University of Singapore Faculty of Medicine
Ministry of Health's Health Manpower Development Plan Scholarship in Urogynaecology & Pelvic Floor Reconstruction Surgery tenable in Melbourne, Australia Singapore Health Quality Service Award SingHealth Excellence Award SGH Service with a Heart Award Gold EXSA Award, 2008
Former Senior Consultant at the Department of Obstetrics and Gynaecology, Singapore General Hospital
Former Co-Director, Pelvic Floor Disorder Service, Singapore General Hospital
Former Clinical Lecturer, Yong Loo Lin School of Medical, National University of Singapore
See more [ + ] Examiner, MBBS Obstetrics and Gynaecology Examinations, Yong Loo Lin School of Medicine since 2003
Fortis Hospital
Gleneagles Hospital
Mount Alvernia Hospital
See more [ + ]Mount Elizabeth Hospital
Mount Elizabeth Novena Hospital
Parkway East Hospital
Thomson Medical Centre


Plaintiffs brought an action against the City of Marietta, Georgia, challenging the validity of its zoning ordinance. The district court granted summary judgment in favor of the city and against plaintiffs on all claims except for one plaintiff's claim (Covenant) that the city's ordinance, as amended in November 2004, facially violated the Religious Land Use and Institutionalized Persons Act (RLUIPA), 42 U.S.C. 2000cc, by treating religious assemblies less favorably than non-religious assemblies. The court held that claims seeking injunctive relief were moot in light of the passage of the 2008 Ordinance and dismissed those claims for lack of subject matter jurisdiction. The court held that, to the extent that RLUIPA claims sought damages, they failed on the merits because all damages stemmed from Covenant's inability to build a church in the R-2 residential zone and Covenant was not entitled to build a church in that zone. The court further held that the district court did not err in concluding that the 2004 Ordinance facially violated the equal terms provision of RLUIPA and did not err in awarding nominal damages for this claim. The court finally held that the district court did not abuse its discretion in denying Covenant's motion to leave to amend the complaint.


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Crux has grown up a little bit today with the launch of our new Arts & Culture section - edited by Poppie Johnson.
I've known Poppie for a few years and she is not only brimming with talent and enthusiasm, but has a real empathy with writing plus all the creative things that make life extra special.
Art and Culture defines us, therefore the Southern Lakes could not be in better shape. I suspect we have more creative talent here per capita than any other place in New Zealand. Sadly, this essential part of our community does not always get the support or attention it deserves. Crux Arts and Culture aims to fix that.
We'd love for Crux Arts & Culture to become the Hub for all things artistic in the district - to help publish projects, help connect funding with the arts, and increase awareness of just how fundamental it is for our community to embrace this part of our lives.
Please support Poppie and our new section with comments and sharing on social media. Offer to write something. Paint something. Photograph something. Do something - but please be part of it. It's important.