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Leah Michelle Hamilton | Singer Songwriter Miracle Album | The Stories Behind "Miracle"
When we are in unfamiliar surroundings or going thru experiences that we don't understand it can be frightening. We may not understand the culture or why something is happening. We may not like the smells or noises, and we may not like how we are affected. This song reminded me of a time when traveling to a country half way around the world that I am never alone. I realized home was not a house, but the relation that I had with my husband and God. Because of that there was meaning in being there, and I had protection and companionship. God showed up in the kindness of many people I met, and the love story of my daughter was being written while we were there. I grew to love the kind people, their culture, traditions, foods, and beautiful surroundings.
During a very sorrowful time in my life I had many sleepless nights, my mind was filled with concern during the day, and I felt so alone. I discovered thru this time that a number of seemingly small things began to remind me that God was there even though I did not feel it, and that he seemed to provide an angel that gave me small gifts that reminded me of the Giver. One of the most beautiful sunrises after a sleepless night, a family of raccoons strolling by my window, finding a Bible passage that spoke to my heart in that very moment, strangers saying encouraging things to me as though they knew me and they didn't, and an unmistakable miraculous presence of comfort and safety, these were reminders that my angel was back. He was always there and had never left.
One of the places I go to walk and rejuvenate is a local wilderness area. One day there was a young girl who began walking behind me who started to cry and in a desperate voice was quietly saying she needed a miracle. Very quickly another girl joined her who seemed to be her friend. That friend was her miracle in that moment as she was no longer alone, seemed to feel comforted and encouraged. This was a reminder to me how many miracles of love and life come thru our friendships, family, spouses, boyfriends, and girlfriends who in a moment transform darkness and loneliness into peace and hope. Most of all our God is ever present and uses these people who love us and we them to give miracles. If you listen closely you will hear the whispered words over the piano solo towards the end, "Save me Jesus." We may say this in desperation, but His "saving" is available every minute.
This is a really fun love song to have written. The music was inspired by an 1900s Russian romance folk song, "Dark Eyes." This is about the kind of unconditional love that is so deep. It is truly an indescribable gift to be known so well by someone that despite knowing all of our flaws, mistakes, and shortcomings, they see our heart and potential, and encourage us to be more.
This song developed during a time that I became acutely aware of the terrible price that Christ paid in horrible pain and death so that we might be free of guilt and shame, and in its place we are offered salvation, freedom, and forgiveness. What He did causes peace and love to rain down on us every day of our lives, even thru hardships.
This song is inspired from one of my favorite hymns growing up. This is a reminder of how God loves to be with us, spend time with us, converse with us. There is delight in lingering in a garden with someone we love, where time slows, beauty surround, and there is that one special person's full focus and they ours. God loves that kind of "Garden Walk" with us.
This song was made as a combination of several Psalms and passages from Revelation which have been so comforting and assuring to me, especially in losses of loved ones. It is a reminder we are journeying toward a different country unlike the one that we live in. In the world that we are heading for Christ is on the throne and loss and sorrow will be absent. Only gladness, worship, and gratefulness will exist for what He has done and what tremendous excitement there will be for what He has in store for us. Every race, gender, and culture that accepts Christ will join together to experience the love, peace, and belonging of God.
This was a song without lyrics. It is a song about reminiscing. When we look back on seasons of our live we often feel not a singular emotion, but a variety of pain and joy, disappointment and pleasure, sadness and happiness, grand moments and mundane ones. Each time I listen to this song I think of something different in the past. While we may look back with regrets and lessons learned, reminiscing also helps us to look at the whole of our lives and extract the good, of giving love and being loved, growth and change, learning what we are capable of, and the ability to have a personal relationship with God.
The miracles God reveals to comfort in times of fear.
The miracle of walking alongside a friend or stranger when they need support or encouragement. We all have a need to be deeply known by another.
When we reach out to others we are giving a precious gift of wanting to find them and see them. I have also found when we give love away it returns in ways we can't imagine.
the Prince of Peace who offered the ultimate price of peace.
The future miracle of hope for a "Heavenly Country" where there will be no more tears or sorrows.
To Mike Garson for working on each song with me from beginning to end to illuminate the musicality, inspiration and Spirituality of every note. It was an extraordinary privilege to develop each piece by your side, and to have your passion and undeniable talent for the piano breathe life into this album.
To Austin Creek for your engineering, recording and mixing expertise, as well as your wonderful vocal work. Your skills are unmistakably evident and I am very grateful for the time and heart you put into this album.
It was a great pleasure to have a variety of talented vocalists share their voices in these songs—each unique and pertinent to the heart of Miracle. Thank you for your beautiful melodies.
To Stacey Stanley for interior album design and overall CD production. Torie Hamilton for design consultation, and Soren Iverson, for exterior album design. Kelsie and Daniel Salarda for inspiration for "Wandering Stranger." Karin and Matthew Draper for continued support and inspiration. Mom and Dad, this would not be possible without you.
Dedicated to my husband, Larry: The only place I want to be is where you are in the world.
Yes, support local businesses and friends! "Undivided Heart" CD is available locally at Rejoice Bookstore at 27851 Via Fabricante in Mission Viejo, California. Check out all my music and browse the beautiful new store.


When we step in stopped escalator, we strongly feel odd sensation called "IWAKAN" in Japanese. Previous study argued that one could not suppress the motor program for "moving escalator" regardless of full awareness of escalator condition (i.e. escalator is stopped) and that the discrepancy between predicted and actual sensory feedback triggered an odd sensation. Furthermore, some could argue that structural nonuniformity of stopped escalator (i.e. the first step is shorter than other steps) caused clumsiness, and this clumsiness induced IWAKAN. We examined these possibilities by comparing the performance to stopped escalator with those to moving escalator and to the wooden stairs which duplicated the structure of stopped escalator. Our results did not support these possibilities. Specifically we correctly recognized the state of the escalator and adequately performed our action before stepping in stopped escalator. Once stepped in stopped escalator, drastic posture forward sway was observed. This sway was not observed in the performance to wooden stairs. These results suggested a new possibility which implied the motor program for moving escalator subconsciously emerge only after we stepped in stopped escalator. We also analyzed the participants' report of IWAKAN after stepping stopped escalator and wooden stairs. Participants felt no IWAKAN after stepped in wooden stairs. On the contrary, when stepped in stopped escalator, they felt IWAKAN, and we identified the kinematic index correlated with participants' report of IWAKAN.


This must be one of my favorite sections of the b-logging.com website! This is the area where you can compile your own unique blog piece and offer it for submission to this site. As a writer myself, I have over the years struggled to find a quality website to submit my work to, so I have worked tirelessly to ensure this is an exciting and hassle-free area that anybody interested in contributing to can do so with the minimum amount of fuss.
If you would love to be a part of the b-logging.com journey, please contact me using the contact form below for further details on this fantastic opportunity.
I am looking for the most interesting, informative and relevant guest blog posts that I can possibly find on the internet! My readers want to access reading material that is up-to-date, easy to understand but most certainly offers something of value during the reading experience. Do you know of a current trend doing the rounds online, have you found an honest way to make money online or have you tried and tested a new gadget before its release date, and you just can't wait to tell everyone about it? Whatever your reason for writing a blog post, if it conveys some form of expertise, knowledge or advice, I am keen to hear what your article has to offer the b-logging.com community.
This list has been compiled through taking a closer look at the search figures of visitors who come to this website. It, therefore, reflects the types of article subjects that people tend to look for the most on b-logging.com. However, because I know how trends and indeed tastes change, I am always revising this list and looking to add to it when the need arises, so it is a good idea to keep an eye on this section of the website for potential updates.
Alternatively, if you are still unsure if your blog post will fit into any of these categories, please don't dismiss it. Instead get in touch with me, and we can discuss its potential. You never know, you may just be the person who adds yet another category to the above list!
How Do the More Successful of People Motivate Themselves?
What Are the Top Trending Gadgets of The Season?
How Can I Derive Inspiration from The Art of Blogging?
Who Can Write for My Website?
As a writer myself, I have a vast experience of trying to find a reputable website to submit my work to. Because of this understanding, I have concluded that it is not about who you are, but what you know when you submit to b-logging.com. I am not interested in your credentials or any possible writing qualification. That is not what this community is about. I am merely interested in your opinion through the written word.
I hope that everyone who visits this website will feel as though they are able to submit their own words for inclusion to the site at any given time. I firmly believe that if you feel passionate about a subject or have some advice which you honestly think would benefit others, then that is all that you need to be able to compile a blog post. I don't want you to get distracted by grammar, paragraphs, and commas, I merely wish to read about what you have to offer the b-logging.com community.
Why Contribute to My Blog?
By offering the website and its readers a well-constructed and thought-provoking blog post, it is only right that you be acknowledged for your well-intentioned input! I, therefore, make it a rule that anybody who writes for this website is credited and their name will appear pride of place next to their blog piece. I also like to add a small bio of the author and mention a link back to their social media account where possible. This way I believe you get the attention you so thoroughly deserve for contributing to this progressive community.
Ultimately, by submitting to this website, I hope you develop a confidence from seeing your words on the screen and that this encourages you to write more! That feeling you get when you have your first piece published is at times beyond words, and I would love for you to be able to experience that thrill of getting your written words out there for the broader community and online world to access.
Just as I don't want you to become too distracted with your writing presentation, I also do not want you to worry about the submission process of b-logging.com. Therefore, I have worked to ensure that this part is the easiest and, once you have sent me your completed article, I will take care of the rest.
If you would prefer to get in touch with me first regarding your potential ideas for a blog post, I would be more than happy to offer you some guidance on your next steps. However, if you have written up your blog post already and want to access my advice, get in touch with me as soon as you can, and I will go through it all with you.
For anything related to the subject of blog guest posts, you can access my help directly through the contact form below. Either way, I look forward to hearing your ideas.


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This is a pure and fresh style of Europe and the United States. The color of a shirt is mosaic multi-colors and has an elegant lapel that will attract the eyes of any potential suitor. The pressed white collar stands out on the shirt and gives it a crisp look. This shirt is very casual with a slim silhouette. The shirt's sewing and workmanship is very fine and has a solid texture. This is a very good choice for young ladies who want a fresh, updated look. This has a London quality to it. This is something you would see on the young ladies in London walking down the street on a casual day. This is a great shirt to wear in the spring or summer. This shirt would match very well with white pants and shoes. It will get you attention and compliments from many people. The shirt comes in S, M, L and XL sizes.


Celebrate the 20th Anniversary of Upper Deck MVP hockey trading cards! The 2018-19 MVP hockey card collection has an impressive 250 card base set to collect! Find phenomenal new rookie cards including the base set High Series SP's falling 1 in 4 packs. Another good find would be the Silver Script Parallels hitting 1 in 7 packs.
This box contains 36 packs per box, 5 cards per pack.


That claim is sadly resonant. We've probably all encountered a Christian whose behaviour has challenged our faith in Christ and his Church. Even more certainly, our own behaviour has somewhere, some time, scandalised someone.
I don't mean scandalised like 'pass-the-smelling-salts I-think-I-might-faint scandal,' which is a quaint relic of the past. Skandalon is the Greek work for "stumbling block." It's easy to imagine one's bad temper, or lack of charity, or rank hypocrisy, becoming a stumbling block to another person's faith in the truth and authority of Jesus Christ. As a young lawyer working in South Africa, Gandhi was scandalised by the racism he observed in men and women who called themselves Christians. Hence his devastating observation.
Pope Francis, it seems to me, invokes this tragedy often, when he rails against modern-day scribes and Pharisees in his daily homilies. I think it must underly his zealous emphasis on the mercy of God. He knows — as we all know — that there are millions and perhaps billions of people who seek a peace the world cannot give, but the scandalous witness of some Christians prevents them from approaching Christ. The pope's solution, I think, is to preach the mercy of God in season and out of season.
In calling the Year of Mercy, he's conscripting the rest of the Church to join his effort. Just as the behaviour of Christians can be a stumbling block to faith, so the behaviour of Christians can be a bridge to Christ; a channel of grace. The witness of the saints is proof enough of that.
What if every Christian corresponded with the grace pouring down from Heaven during this Year of Mercy, and became another face of the mercy of the Father; another Christ? This, I think, is the Holy Father's noble vision for this holy jubilee. Hence his exhortation that we become familiar with the works of mercy, and practice them as often as we can.
I have suggested to my parishioners that conscientiously enacting each of the fourteen works of mercy constitutes a good Lenten discipline. To that end, I have distributed the attached document as an aid. Some of the illustrating examples are very good, and others are trite. But that's good! It might motivate you to discern better applications proper to your context.
NextAslan is not a tame lion; and you're a hypocrite!


For more than 30 years, I have represented those injured or the families of those killed by preventable crashes on our highways. Many of these claims have involved semi-trucks and trucking companies.
I read an article in Transport Topics expressing the importance of trucking. This op-ed was written by Garner Berry, a lawyer whose law firm defends these trucking companies and truck drivers.
Mr. Berry loves driving. He thought about being a truck driver. He points out that the trucking industry is invaluable to the American economy.
All too often, I am contacted by families whose members have suffered serious injuries or been killed by preventable crashes caused by a truck driver who lacked proper training, or was speeding, or distracted.
Recently, my law firm represented a teenager. This kid was driving home from a high school sports practice. He signaled his left turn. He stopped, waiting for an opening in traffic.
And then he was hit from behind by a truck driver who was just not paying attention.
The truck driver's failures resulted in a major crash, and very serious injuries to both my client and another driver.
The truck driver could not explain his failure.
He was on a roadway where folks commonly stopped to take left turns.
The above picture tells you enough about this story. It's a difficult image to see through rose-colored glasses.
First of all, no one needs to tell the public to fear the trucking industry.
That fear often comes from the experience of being passed by a 70,000-pound tractor-trailer, buzzing down the highway at 80 mph.
Secondly, it's normal to feel fear when you see images of terrible crashes—like my client above.
The solution to these fears is not to stop telling the stories of truck crash victims: it is to stop the truck crashes.
Are run by companies that may value profit over safety.
However, wisdom and experience teach us that one size does not fit all.
Not all trucking companies are bad.
Not all trucks should be feared.
But the statistics must be considered when looking at the industry.
It's been my experience that the public understands very well that professional truck drivers are trained more thoroughly than other drivers—as they should be.
We agree: commercial truck drivers operate large and potentially dangerous pieces of equipment. Therefore, they are held to a higher standard of care than regular motorists.
Fail to adhere to the federal regulations set by the Federal Motor Carriers Safety Administration (FMCSA).
involving large trucks and buses.
As you know, I represent families who've experienced serious injury or death in truck crashes. Mr. Berry defends trucking companies.
But there are some fundamental points that we could agree upon.
We agree: commercial trucking is important to our economy and way of life.
We could probably agree that properly designed and well-maintained roads are important.
And that the safety of those roads is important.
We could agree that well-trained truckers and law-abiding trucking companies are important part of that safety.
But we do disagree on one fundamental point.
Mr. Berry believes that revising the public perception of safety in the trucking industry should be a priority.
I strongly believe that safety itself should be at the forefront of the industry.


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IJK's Radio Interview On Light FM Lebanon
On July 19th 2017, IJK was interviewed by renowned french anchor Tanguy Faucon on Light FM Lebanon (90.5 FM), a leading radio station in Lebanon. The interview was aired during the last part of Tanguy's famous morning show "La Bonne Humeur".
Many topics were discussed including IJK's latest singles, his future plans and the current state of western music in the Middle East and the world.
You can find the full replay of the interview below:
https://soundcloud.com/lightfmlebanon/ijk-danse-avec-les-ombres
IJK Receives Positive Reviews For Latest Single "Dancing Shadows"
Following the release of IJK's latest single "Dancing Shadows", a number of news outlets have positively reviewed IJK's music and praised his singing and songwriting abilities.
Among these, the famous indie music magazine "Independent Music News 24" has written a rave review which you can find below:
http://independentmusicnews24.com/releases/ijk-dancing-shadows-a-polished-and-genuine-piece-of-music
IJK, Singer Songwriter
IJK's Bio | IJK's Music | IJK's Photos | Shop IJK's Music | IJK's Blog | Contact IJK
music.ijk@gmail.com, IJK (Imad Jack Karam), 2019 All Rights Reserved

redpajama_set_name: RedPajamaCommonCrawl


Walk to Lake Bottom Park from this brick Midtown condo! The foyer invites you into the living room with a fireplace and hardwood floors. The eat-in kitchen has been updated with tile floors, granite, stainless appliances, subway tile back splash, and track lighting. The separate dining room can also be used as a den, and it leads out to a private brick walled patio. The bedrooms are generously sized and the master bath has separate vanities and a walk in closet. Lots of extras, too!


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Alan Haynie joined ICES Secretariat as General Secretary in August 2022.
Alan has been involved in ICES network for many years, including serving as Chair of ICES Strategic Initiative on the Human Dimension (SIHD) and the US alternate member to ICES Science Committee (SCICOM), and chairing numerous expert groups. He has diverse experience with marine science and economics leadership, stakeholder engagement, climate change research, policy analysis and development, strategic planning, and organizational excellence. Before coming to ICES, Alan spent 18 years at NOAA Fisheries in Seattle, Washington, USA, with a focus on both regional issues in the North Pacific and national initiatives. He has a demonstrated commitment to diversity, equity, and inclusion in the workplace.
Alan has organized dozens of scientific workshops and conferences and effectively communicated with diverse audiences including the public, fishery managers, Congressional staffers, NOAA leaders, and indigenous as well as large-scale commercial fishers. He led the development of the NOAA Fisheries Human Dimensions Plan and the Rightsizing Project, which examined the long-term resource changes across US fisheries science centers. He served for 14 years on the Bering Sea and Aleutian Islands Plan Team and has organized workshops to improve interdisciplinary methods in stock assessment and integrated ecosystem assessments. He was an author of the US National Climate Assessment and has been a leader in interdisciplinary marine climate science. Earlier in his career, Alan received the Presidential Early Career Award for Scientists and Engineers (PECASE) from President Obama.
Alan grew up in and near New Orleans, Louisiana, USA, a culture rich in fisheries and maritime uses. He studied economics and international relations at Stanford University and obtained a PhD in economics from the University of Washington.
"I was drawn to the role of ICES General Secretary for many reasons. The need to collaborate to address the many scientific and management challenges of our time has never been greater. We have a unique opportunity to strengthen all aspects of the network to expand the impact of ICES and deepen the rigor and interdisciplinary content of our science and advice."
Alan Haynie, ICES General Secretary


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Petříček: Free movement between Czech Republic and Austria from mid-June
The foreign ministers of the Czech Republic and Austria have agreed to allow free movement of people between the two states from mid-June. The Czech minister of foreign affairs, Tomáš Petříček, made the announcement on Tuesday after speaking to his Austrian and Slovak counterparts. Talks on free movement between the Czech Republic and Slovakia will continue, Mr. Petříček said, adding that similar negotiations with the Hungarian government were planned.
The news means that people who cross the Czech-Austrian border will not need to enter quarantine or produce a negative Covid-19 test. The agreement still needs to be ratified at government level, Mr. Petříček said.
Ministers Petříček, Zaorálek team up to promote Czech culture abroad
Borders open as map of Europe "goes green"
Free movement between Czechia, Austria and Hungary restored
Foreign minister to Czechs seeking "settled status" in UK: Time and reliable information are…


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Utahns for Civic Engagement
About UT4CE
Apri 15: Taxation Without Representation? We Pay, We say!
Civic Engagement Trivia
Community and Civic Resources
Utah Advocacy Groups
Equality and Human Rights
Utah Communities
Utah Political Action Groups
Utah Political Parties
Film Inventory: Lending Library
Civil Liberties, Constitutional Rights
Taxes and Representation
War, Military, Terrorism
Countdown to Zero (2)
2010, 89 mins
Although the Cold War is behind us, the threat of nuclear disaster remains very real. Director Lucy Walker discusses the invention of the atomic bomb and brings the story into the present day, examining the possibility of nuclear calamity under the categories of "Madness," "Accident" and "Miscalculation." With narration by Gary Oldman, the film includes a hypothetical sequence of a nuclear explosion in New York City's Times Square, timed to coincide with the New Year's Eve countdown.
Discussion Guide: CTZP_discussion_guide_010611_v02
A peaceful Midwestern city attempts to recover after it is destroyed by a nuclear missile strike in this powerful and deeply disturbing testament to the folly of pro-military hawks who believed that annihilation was a justifiable means of attaining power and control. The Day After originally aired on network television. At the end of the broadcast, many stations offered teams of counselors staffing 800 telephone numbers to help distraught viewers calm down.
Utahns for Civic Engagement promotes civic engagement in the community, thru both political and non-political processes.
Utahns for Civic Engagement is an independent non-partisan educational initiative of Blue Sky Institute.
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See our calendar of events page at:
Central City Neighborhood Council February 1, 2023 at 6:00 pm – 8:00 pm Public Safety Building Community Rooms A & B 210 South 300 East, # 116 Salt Lake City, 413-3167 chair@ccncutah.org
Ballpark Community Council Meeting February 2, 2023 at 7:00 pm – 9:00 pm Taylor Springs Apartments Community Room 1812 South West Temple http://www.slcdocs.com/comcoun/pdfs/Community_Orgs_List.pdf
Downtown Community Counci Meeting February 15, 2023 at 6:00 pm – 8:00 pm Union Pacific Depot – Ticket Office (Main Floor) 400 West South Temple FAcebook page: https://www.facebook.com/downtownslccc 937-4473council phone christian.harrison@gmail.com
Capitol Hill Community Council Meeting February 15, 2023 at 6:30 pm – 8:00 pm Marmalade Library Multi - Purpose Room, 280 West 500 North Website: http://chnc-slc.org/
East Bench Community Council Meeting (No meeting in Jul, Dec) February 15, 2023 at 7:00 pm – 9:00 pm Anderson - Foothill Library 1135 South 2100 East No meeting in Jul, Dec Website: https://eastbenchslc.org/ 801-550-9538 eastcentralcommunity@gmail.com
Copyright © 2017 Utahns for Civic Engagement - All rights reserved.


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Young@Heart + Chicago Children's Choir = Mash-Up VII
WHAT: Mash-Up VII: The Young@Heart Chorus (Y@H) and Chicago Children's Choir (CCC)
WHEN: Saturday, May 4 @ 7:30PM
WHERE: Academy of Music Theatre, Northampton MA
The Young@Heart Chorus (Y@H) and Chicago Children's Choir (CCC) team up once again for Mash-Up VII on Saturday, May 4 @ 7:30PM at the Academy of Music Theatre, Northampton MA. Tickets are available at aomtheatre.com or by calling the Academy box office at 4134-230-9032 ext. 102
Y@H and the CCC close the generation gap in Mash-Up VII. The choruses are world renown for their commitment to changing lives through music, albeit from different stages of life. The Choruses will sing separately and together. Together they will explore music from Matisyahu to the Specials and Manhattan Transfer to Chicago's own, Sly and the Family Stone...and much more.
"One Day" w/ Y@H and CCC from 2014 https://www.youtube.com/watch?v=xwpyDP_PjEM
The Hyde Park Neighborhood Choir of Chicago Children's Choir is one of the shining lights of the South Side of Chicago. CCC Director Mollie Stone, who attended Amherst College, describes the impact of the collaboration:
"When our Chicago Children's Choir Hyde Park Neighborhood Choir toured to Northampton, Massachusetts in 2014 to collaborate with Young@Heart, our singers' lives were transformed. For the first time, they realized that the powerful experience of singing together and creating community within the context of an ensemble was a gift they could share for their entire lives. They started to understand that their music- making truly functioned as a way to create community with people from any background, any age, and any part of the world. Our singers had been performing for their elders at senior centers around Chicago for years, but had never had the chance to see their elders as fellow performers, and collaborators. Witnessing an entire ensemble of elderly singers coming together to sing music from genres that are usually perceived as belonging to the "younger generation" also gave our singers an important understanding that one can cross the imagined boundaries imposed on us by society—that they have the ability to learn about any type of music, and connect with the people who love it, and perform it."
Mash-Up VII is sponsored by Greenfield Savings Bank, Lathrop Communities, Christopher Heights, Daily Hampshire Gazette, Valley Advocate, The River/WHMP, the National Endowment for the Arts, the Mass Cultural Council, and the Davis Foundation.
Poster attached. Photos furnished upon Request.
For more information please contact Bob Cilman info@youngatheartchorus.com or call 413-230- 7909.
Chicago Children's Choir (Josephine Lee, President and Artistic Director) is the nation's preeminent youth choral organization, serving over 5,000 students across the city of Chicago. Founded in Hyde Park in direct response to the Civil Rights Movement in 1956, CCC has grown from one choir into a vast network of in-school and after-school programs driven by one mission: to inspire and change lives through music.
As a national and international touring ensemble, Chicago Children's Choir has performed throughout the United States, in Cuba, South Africa, India, Argentina, Uruguay, Korea, Canada, Japan and Europe and for such dignitaries as former President Barack Obama and former First Lady Michelle Obama, former President Bill Clinton, former Secretary of State Hillary Clinton, Chicago Mayor Rahm Emanuel, former Chinese President Hu Jintao, former South Korean President Lee Myung-Bak, Nelson Mandela, Archbishop Desmond Tutu and His Holiness the XIVth Dalai Lama Tenzin Gyatso.
CCC has performed with or for such acclaimed artists as Renée Fleming, Denyce Graves, Kathleen Battle, Luciano Pavarotti, Samuel Ramey, Yo-Yo Ma, Andrea Bocelli, Josh Groban, Enrique Iglesias, Quincy Jones, Al Green, Brian Stokes Mitchell, Ladysmith Black Mambazo, Bobby McFerrin, Kurt Elling, Celine Dion, Eddie Vedder and Beyoncé. CCC has recorded on multiple labels including James Ginsburg's Cedille Records (Songs from Spoon River, 2009) and has released five studio recordings under its own label– We All Live Here (2016), Holiday
Harmony (2010), Songs on the Road to Freedom (2008), Sita Ram (2006) and Open Up Your Heart (2004).
Young@Heart
What started out in 1982 at a Western Massachusetts elderly housing project to joyfully pass the time instead of passing before your time has developed into the stereotype- defying, generation-crossing musical extravaganza better known as The Young@Heart Chorus. From The New York Times to TIME, The Tonight Show to The Ellen Show and stars of the Fox Searchlight Top 50 all-time documentary, Young@Heart, this group of fearless seniors, ranging in age from 73- 92, has toured from Northampton to New Zealand, Europe to Japan. Featured in E*Trade's acclaimed Super Bowl ad This Is Getting Old (2018), Young@Heart continues to wow audiences worldwide while conducting weekly rehearsals and concerts with incarcerated singers in two local prisons through their PrisonVision program launched in 2014. In their annual Mash-Up concerts, they collaborate with the best youth performance groups, including Staten Island's PS22 Chorus, Chicago Children's Choir, and the Brooklyn Youth Chorus.
Posted by Northampton Arts Intern at 9:05 PM


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Q: Grid Search in Multi class classification problems using Neural networks I'm trying to do grid search for a multi class problem in neural networks.
I am not able to get the optimum parameters, the kernel keeps on compiling.
Is there any problem with my code? Please do help
import keras

from keras.models import Sequential
from keras.layers import Dense

# defining the baseline model:

def neural(output_dim=10,init_mode='glorot_uniform'):
    model = Sequential()
    model.add(Dense(output_dim=output_dim,
                    input_dim=2,
                    activation='relu',
                    kernel_initializer= init_mode))
    model.add(Dense(output_dim=output_dim,
                    activation='relu',
                    kernel_initializer= init_mode))
    model.add(Dense(output_dim=3,activation='softmax'))

    # Compile model
    model.compile(loss='sparse_categorical_crossentropy',
                  optimizer='adam',
                  metrics=['accuracy'])
    return model

from keras.wrappers.scikit_learn import KerasClassifier
from sklearn.model_selection import cross_val_score
from sklearn.model_selection import KFold
from sklearn.model_selection import GridSearchCV
estimator = KerasClassifier(build_fn=neural,
                            epochs=5,
                            batch_size=5,
                            verbose=0)

# define the grid search parameters
batch_size = [10, 20, 40, 60, 80, 100]
epochs = [10, 50, 100]
init_mode = ['uniform', 'lecun_uniform', 'normal', 'zero',
             'glorot_normal', 'glorot_uniform', 'he_normal', 'he_uniform']
output_dim = [10, 15, 20, 25, 30,40]

param_grid = dict(batch_size=batch_size,
                  epochs=epochs,
                  output_dim=output_dim,
                  init_mode=init_mode)

grid = GridSearchCV(estimator=estimator,
                    scoring= 'accuracy',
                    param_grid=param_grid,
                    n_jobs=-1,cv=5)

grid_result = grid.fit(X_train, Y_train)

# summarize results

print("Best: %f using %s" % (grid_result.best_score_,
                             grid_result.best_params_))
means = grid_result.cv_results_['mean_test_score']
stds = grid_result.cv_results_['std_test_score']
params = grid_result.cv_results_['params']
for mean, stdev, param in zip(means, stds, params):
    print("%f (%f) with: %r" % (mean, stdev, param))

A: There's no error in your code.
Your current param grid has 864 different combinations of parameters possible.
(6 values in 'batch_size' × 3 values in 'epochs'  ×  8 in 'init_mode'  ×  6 in 'output_dim') = 864
GridSearchCV will iterate over all those possibilities and your estimator will be cloned that many times. And that is again repeated 5 times because you have set cv=5.
So your model will be cloned (compiled and params set according to the possibilities) a total of 864 x 5 = 4320 times.
So you keep seeing in output that the model is being compiled those many times.
To check if GridSearchCV is working or not, use its verbose param.
grid = GridSearchCV(estimator=estimator,
                    scoring= 'accuracy',
                    param_grid=param_grid,
                    n_jobs=1,cv=5, verbose=3)

This will print the current possible params being tried, the cv iteration, time taken to fit on it, current accuracy etc.

redpajama_set_name: RedPajamaStackExchange


text:
Q: Definition of localized source in electrodynamics I'd like to know the exact definition in classical electrodynamics of a localized source, e.g. localized charge density $\rho(\mathbf{r},t)$ or localized current density $\mathbf{J}(\mathbf{r},t)$.  Do we merely require that $\rho(\mathbf{r},t) \rightarrow 0$ or $\mathbf{J}(\mathbf{r},t) \rightarrow \mathbf{0}$ as $r \rightarrow \infty$, or is there a requirement on the speed of the convergence?
I can't seem to find a precise definition in any standard textbook -- most just seem to say the densities must go to zero, but I'm not sure this is enough to make certain integrals converge.


However, Merkle's policies and views on migration have made her unpopular amongst the most conservative and the increasingly powerful far right, both in Germany and in the EU.
On the eve of the CDU voting on Angela Merkle successor for the 2021 Germany election, Reuters published in its photojournalism website "The Wider Image", a piece that tells the stories of three migrants in Berlin: Ali Mohammad Rezaie from Afghanistan, Haidar Darwish from Syria and Joseph Saliba, from Syria.
They are stories about their own personal pathways to integration in the city of Berlin.


text:
Justia Patents Drug, Bio-affecting And Body Treating Compositions Patents Designated Organic Active Ingredient Containing (doai) Patents Carbohydrate (i.e., Saccharide Radical Containing) Doai Patents O-glycoside Patents Oxygen Of The Saccharide Radical Bonded Directly To A Nonsaccharide Hetero Ring Or A Polycyclo Ring System Which Contains A Nonsaccharide Hetero Ring Patents The Hetero Ring Has 8 Or More Ring Carbons Patents (Class 514/28)
The Hetero Ring Has 8 Or More Ring Carbons Patents (Class 514/28)
The hetero ring has exactly 13 ring carbons (e.g., erythromycin, etc.) (Class 514/29)
The hetero ring has exactly 15 ring carbons (Class 514/30)
The hetero ring has 20 or more ring carbons (e.g., nystatin, etc.) (Class 514/31)
Water dissolvable macrocyclic lactone cyclodextrin complexes
Abstract: Injectable Ivermectin solution is safely administrable to humans and animals used the disclosed technology. A macrocyclic lactone cyclodextrin complex which is completely dissolvable or dissolved in water in a ratio of at least 50 micrograms to 500 milligrams of the macrocyclic lactone complex per 5 milliliters of water. The macrocyclic lactone cyclodextrin complex is non-toxic, without using organic solvents, and in embodiments, formed by adding a surfactant to the macrocyclic lactone complex to water. The macrocyclic lactone cyclodextrin complex is Ivermectin or an Ivermectin derivative in some embodiments. The cyclodextrin complex is 2-hydroxypropyl-beta-cyclodextrin in some embodiments of the disclosed technology. The surfactant can be polysorbate 80 and is in a ratio of 0.01% to 25%, by weight, to said water. The water soluble complexes can be added to the water. The water-soluble complexes can have at least one of an anti-parasitic, anti-viral and anti-cancer complex.
Date of Patent: August 3, 2021
Assignee: MOUNTAIN VALLEY MD INC
Inventor: Michael Farber
Use of avermectin derivative for increasing bioavailability and efficacy of macrocyclic lactones
Abstract: The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) wherein: (i) R1 is chosen from the group constituted of —CH(CH3)2, —CH(CH3)CH2CH3, or cyclohexyl, (ii) X represents —CH2—CH2—, or —CH?CH—, (iii) R2 is chosen from or an OH group, (iv) R3 is OH or NOH, (v) represents a single bond when R3 is OH, or a double bond when R3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.
Date of Patent: June 1, 2021
Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARN
Inventors: Anne Lespine, Roger Prichard, Cecile Menez
Process to improve crop yield
Abstract: The present invention relates to a process to improve the yield of strawberry crops, the process comprising the step of applying a polyene antifungal agent, especially natamycin, to the roots of a strawberry plant prior to planting said plant and/or to the medium to which the plant is to be planted. The claimed process results in an increased number of crop, an increase in the weight of individual crop, and an increase in the total weight of the crop, and may allow for an earlier harvest.
Assignee: DSM IP ASSETS B.V.
Inventor: Manoj Kumar
Homogeneous ophthalmic composition
Abstract: This application is directed to a homogeneous solution of an aqueous, topical composition useful for the treatment of infection and/or for the treatment of inflammation due to trauma to tissue. Specifically, this application relates to a homogeneous, aqueous composition of a quinolone antibiotic and an anti-inflammatory agent.
Inventor: Randal Davis
Veterinary composition comprising imidacloprid, moxidectin and praziquantel for cutaneous topical application (spot on), for the treatment and prevention of ecto and endoparasitoses affecting dogs
Abstract: A monodose veterinary composition for topical application (spot on) for canines, the said composition comprising: (a) Imidacloprid, between 8.18 and 10.00%, (b) Moxidectin, between 2.86 and 3.50%, (c) Praziquantel, between 8.18 and 10.00%, and (d) an aprotic solvent selected from Dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMAC), N,N-dimethylformamide (DMF) and their mixtures, between 65.45 and 80.00%; together with excipients acceptable from the veterinary viewpoint, where the percentages are related to the composition's total weight.
Assignee: LABYES USA, LLC
Inventors: Carlos D. Corrales, Jorge A. Dale
Plant parts and extracts having anticoccidial activity
Abstract: Methods of administering a composition that comprises plant extracts selected from the group consisting of Quercus infectoria, Rhus chinensis and Terminalia chebula containing compounds such as gallic acid, derivative of gallic acid, gallotannins and hydrosable tannins, which have been found to control coccidiosis in poultry and, more specifically, coccidiosis caused by Eimeria spp. The plant extracts result in a reduction of lesion score, oocysts per gram of fecal matter and mortality.
Assignee: KEMIN INDUSTRIES, INC.
Inventors: Gokila Thangavel, Rajalekshmi Mukkalil, Haridasan Chirakkal
Plant extracts having anticoccidial activity
Abstract: Natural plant parts and extracts of plants selected from the group consisting of Quercus infectoria, Rhus chinensis and Terminalia chebula containing compounds such as gallic acid, derivative of gallic acid, gallotannins and hydrolysable tannins have been found to control coccidiosis in poultry and, more specifically, coccidiosis caused by Eimeria spp. The plant parts and natural extracts result in a reduction of lesion score, oocysts per gram of fecal matter and mortality.
Inventors: Gokila Thangavel, Rajalekshmi Mukkalil, Haridasan Chirakkal, Hannah Kurian, Elke Schoeters, Hilde Wouters, Ilse Mast
Compositions and methods for treating Crohn's disease and related conditions and infections
Abstract: In alternative embodiments, the invention provides a "triple combination" therapy for treating, ameliorating and preventing Crohn's Disease (or Crohn syndrome, terminal or distal ileitis or regional enteritis) or related disorders and conditions in mammals, such as paratuberculosis in mammals, or Johne's disease, including genetically-predisposed and chronic disorders, where the microbial or bacterial flora of the bowel is at least one causative or symptom-producing factor; and compositions for practicing same. In alternative embodiments, methods and compositions of the invention comprise or comprise use of therapies, medications, formulations and pharmaceuticals comprising active agents that can suppress or eradicate the microbiota super-infection that causes Crohn's Disease or paratuberculosis infection in mammals.
Date of Patent: August 13, 2019
Inventor: Gaurav Agrawal
Methods and systems for determining infection
Abstract: Embodiments of the invention relate to methods and systems for the detection of Mycobacterium tuberculosis. Mycobacterium tuberculosis kills more than one million people each year. To better understand why M. tuberculosis is virulent and to discover chemical markers of this pathogen, we compared its lipid profile to that of the attenuated but related mycobacterium, Mycobacterium bovis Bacille Calmette Guerin (BCG). This strategy identified previously unknown compounds that are specific to M. tuberculosis, e.g. 1-tuberculosinyladenosine, N6-tuberculosinyladenosine, and various tuberculosinyladenosines having mycolic acids, produced by the Rv3378c enzyme.
Assignee: The Brigham and Women's Hospital, Inc.
Inventors: David Branch Moody, Emilie Layre, David C. Young
Process for the preparation of macrolide antibacterial agents
Abstract: Described herein are processes for the preparation of compounds of formula (I): and pharmaceutically acceptable salts, solvates, and hydrates thereof.
Assignee: CEMPRA PHARMACEUTICALS, INC.
Inventors: David Eugene Pereira, Manish K. Patel, Keshav Deo
Compounds for the treatment of diabetes and disease complications arising from same
Abstract: The present invention is directed to use of a series of tri-aryl compounds and compositions comprising the same for the treatment of diabetes and disease conditions arising as a consequence of the same.
Assignee: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
Inventor: Esther Priel
Compositions and methods for treating an infection
Abstract: The present application relates to compounded compositions, methods of making compounded compositions, and methods of using compounded compositions. For example, disclosed herein are compounded compositions and methods of making compounded compositions comprising one or more anti-infective agents such as mupirocin.
Assignee: CMPD LICENSNG, LLC
Inventor: Jay Richard Ray, II
Parenteral formulations of lipophilic pharmaceutical agents and methods for preparing and using the same
Abstract: There may be provided compositions of lipophilic pharmaceutical agents with improved solubility and stability. For example, there may be provided a non-aqueous composition that comprises a lipophilic pharmaceutical agent, and an amphiphilic polymeric solvent such as PEG400 but essentially free of organic solvents and non-solubilized particles. The composition may be further diluted with a desired aqueous diluent such as an infusion fluid for parenteral administration to a subject such as a human. The compositions may be useful for the treatment for diseases or conditions that are sensitive to lipophilic agents, such as infectious diseases, malignant or autoimmune diseases.
Assignee: Platform Brightworks Two, Ltd.
Inventors: Borje S. Andersson, Benigno C. Valdez, Jeffrey Tarrand
Macrolides and methods of their preparation and use
Abstract: Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.
Assignee: President and Fellows of Harvard College
Inventors: Andrew G. Myers, Ian Bass Seiple, Ziyang Zhang
Methods for treating resistant diseases using triazole containing macrolides
Abstract: Described herein are macrolide and ketolide antibiotics and pharmaceutical compositions, methods, and uses thereof for treating diseases caused at least in party by resistant bacteria.
Inventors: Prabhavathi Fernandes, David E. Pereira
Ternary fungicidal and pesticidal mixtures
Abstract: The present invention relates to novel mixtures, to processes for preparing these compounds, to compositions comprising these mixtures, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms or pests in crop protection and in the protection of materials and for enhancing plant health.
Assignee: BAYER CROPSCIENCE AG
Inventors: Haruko Sawada, Stefan Herrmann, Heiko Rieck, Christophe Dubost
Postprandial gastrokinetic agent
Abstract: To provide a therapeutic agent for gastrointestinal disorder such as diabetic gastroparesis. A postprandial gastrokinetic agent containing (A) ghrelin or a ghrelin agonist and (B) motilin or a motilin agonist as active ingredients, in which both the ingredients (A) and (B) are administered so as to act on the stomach after food intake.
Assignees: ZERIA PHARMACEUTICAL CO., LTD., SAITAMA UNIVERSITY
Inventors: Takafumi Sakai, Ichiro Sakata, Kayuri Kuroda, Makoto Yoshimura
Methods of treating lung infection with caspofungin
Abstract: Methods for the treatment and/or prevention of a fungal infection in the pulmonary system of a subject in need thereof with caspofungin or a derivative thereof are disclosed herein.
Assignee: Trilogy Therapeutics, Inc.
Inventors: David M. Ryckman, Iching G. Yu
Aminoglycoside and azole compositions and methods
Abstract: The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring III that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.
Assignee: Utah State University
Inventors: Jon Y. Takemoto, Cheng-wei Tom Chang, Sanjib K. Shrestha, Michelle Grilley
Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
Abstract: A method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by an insect or arthropod sting or bite, or a skin contact with a noxious weed or plant is disclosed. The method includes topically applying a dermatological composition containing an avermectin compound to an affected area immediately after said sting or bite, or said skin contact occurs. The method further includes moistening the affected area first prior to application of the dermatological composition.
Assignee: Galderma S.A.
Inventors: Jeffrey D. Parks, L. Dean Parks
Daptomycin formulations and uses thereof
Abstract: Lyophilized daptomycin formulations having improved reconstitution times are provided. The lyophilized daptomycin formulations include an additive, which can be a pharmaceutically acceptable antioxidant, a pharmaceutically acceptable organic acid or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable glucose derivative or a pharmaceutically acceptable salt thereof, or a combination thereof. Also provided are methods of methods of preparing the lyophilized daptomycin formulations, and methods of treating bacterial infections and treating or preventing biofilms by using the lyophilized daptomycin formulations.
Assignee: HOSPIRA AUSTRALIA PTY LTD.
Inventors: Jim Alexiou, Andrew Knill, Noel Norris, Darryl Whittaker
Methods for treating malaria, tuberculosis and MAC diseases
Abstract: Described herein are formulations and methods for treating diseases caused by infectious pathogens, including mycobacterium avium complex, mycobacterium tuberculosis, Nocardia, Plasmodium falcium, and Plasmodium berghei.
Inventor: Prabhavathi Fernandes
Administration of avermectin/milbemycin compounds for the treatment of ophthalmic pathologies
Abstract: Administration of at least one compound of the family of the avermectins or of the family of the milbemycins, notably ivermectin, is useful for the treatment of ophthalmic pathologies, including ocular rosacea.
Inventors: Alexandre Kaoukhov, Christophe Villard, Philippe Bouissou
Topical combination of fipronil, permethrin and pyriproxyfen
Abstract: The present invention relates to a liquid topical veterinary pharmaceutical composition consisting of fipronil, permethrin at high concentration and pyriproxyfen such that it does not crystallize when it is applied to the coat of an animal, and to the use thereof in the prevention and/or treatment of infestations of domestic animals by external parasites. The present invention also relates to the use of pyriproxyfen as an inhibitor of the crystallization of a liquid formulation comprising fipronil and permethrin at high concentration.
Assignee: VIRBAC
Inventor: Nathalie Delhom
Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria
Abstract: The invention provides methods of treating or preventing malaria comprising administering to an animal an effective amount of a compound of formula (I): Q-Y—R1—R2 (I), wherein Q, Y, R1, and R2 are as described herein. Methods of inhibiting a plasmodial surface anion channel of a parasite in an animal are also provided. The invention also provides pharmaceutical compositions comprising a compound represented by formula (I) in combination with any one or more compounds represented by formulas II, V, and VI. Use of the pharmaceutical compositions for treating or preventing malaria or for inhibiting a plasmodial surface anion channel in animals including humans are also provided. Also provided by the invention are clag3 amino acid sequences and related nucleic acids, vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions.
Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
Inventor: Sanjay A. Desai
Single dose oral formulations and methods for treatment of cats with ectoparasiticidal spinosad
Abstract: This invention provides a single-dose oral formulation of spinosad for the extended control of a C. felis infestation on a cat at a predictable dose of spinosad that is suitable for administration once every 30 days (i.e., one month). The invention also provides methods of using the formulation of spinosad.
Assignee: ELI LILLY AND COMPANY
Inventors: Kari Lynette Riggs, Daniel Earl Snyder, Michelle Leigh Totten
Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use
Abstract: The present invention refers to pharmaceutical formulations based on lipids for ophthalmic use comprising a phospholipid component composed of zwitterionic phospholipids of natural origin and an oily component composed of oils of natural origin emulsified in water. In particular, the invention refers to ophthalmic formulations useful, for example, for transporting drugs to the eye and in the treatment of ocular dryness, capable of restoring the lipid layer of the tear film. In particular, in a non-transitory but pathological situation such as the dry eye syndrome, such formulations also succeed in reducing the often-present inflammatory component.
Assignee: SIFI, S.P.A.
Inventors: Maria Grazia Mazzone, Valeria Maria Carmela Moschetti, Fausto Giuseppe Miano, Letizia Gaetana Lo Grasso
Use of tylvalosin as antiviral agent
Abstract: The invention relates to the use of a macrolide antibiotic, tylvalosin, as an anti-viral agent. Tylvalosin is particularly useful for the treatment of PRRSV.
Assignees: Cambridge University Technical Services, Eco Animal Health Limited
Inventors: Albert Philip Adrian Mockett, Thomas David Kay Brown, Amanda Denise Stuart
Concentrated aqueous azalide formulations
Abstract: Provided is concentrated aqueous azithromycin formulation from about from about 2%-20%, and a method of making a concentrated aqueous azithromycin formulation which includes preparing and sterilizing a first solution comprising a strong base to form a sterilized solution, dissolving the azithromycin in an aqueous solution comprising an acid consisting essentially of a strong acid, and adding the aqueous solution comprising the strong acid to the sterilized solution comprising the strong base. The strong acid has a pKa less than about ?1.74 and the method is carried out without addition or use of a weak acid.
Assignee: INSITE VISION CORPORATION
Inventors: Lyle M. Bowman, Sui Yen Eddie Hou, Tang Nguyen
Treatment of Clostridium Difficile Infection in High Risk Patients
Abstract: The present invention relates to methods of preventing and/or treating Clostridium difficile infection (CDI) in a subject at high risk for developing CDI including subjects receiving antibiotic therapy for a different infection comprising administering to the subject an effective amount of the compounds described herein.
Inventors: Sherwood Gorbach, Pamela Sears, Yoshi Ichikawa
Plant disease control agent with a tetrazolyl oxime derivative and either triflumizole or hydroxy-isoxazole as the active ingredients
Abstract: According to the present invention, a plant disease control agent having a superior control effect on plant diseases at a low dose is provided. The plant disease control agent of the present invention includes at least one selected from tetrazolyl oxime derivatives represented by formula (I) and salts thereof, and at least one selected from the group consisting of imidacloprid, triflumizole, spinosad, hydroxy isoxazole, thiophanate-methyl, tricyclazole, clothianidin, benomyl, acetamiprid and salts thereof. In formula (I), X represents a C1-6 alkyl group or the like; n represents an integer of 0 to 5; Y represents a C1-6 alkyl group; Z represents a group represented by NHC(?O)-Q; Q represents a C1-8 alkoxy group or the like; R represents a halogen atom; m represents an integer of 0 to 3.
Assignee: Nippon Soda Co., Ltd.
Inventor: Ichirou Urihara
Alginate oligomers for use in overcoming multidrug resistance in bacteria
Abstract: The invention provides a method of overcoming resistance to at least one antibiotic in a multidrug resistant bacterium, said method comprising contacting said bacterium with an alginate oligomer together with the antibiotic. The multidrug resistant bacterium may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with a multidrug resistant bacterium to overcome resistance to the antibiotic in said multidrug resistant bacterium. In another aspect the method can be used to combat contamination of a site with multidrug resistant bacteria, e.g. for disinfection and cleaning purposes.
Assignee: Algipharma AS
Inventors: Edvar Onsoyen, Rolf Myrvold, Arne Dessen, David Thomas, Timothy Rutland Walsh
SYNERGISTIC PESTICIDAL COMPOSITIONS AND RELATED METHODS
Abstract: A pesticidal composition comprises a synergistically effective amount of a nicotinic acetylcholine receptor (nAChR) allosteric activator compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)thio) propanamide (I), N-(3-chloro-1-(pyridine-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)sulfinyl) propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by insects comprises contacting the plant with the synergistic pesticidal composition.
Inventors: Luis E. Gomez, Ricky Hunter, Mike Shaw, Tony K. Trullinger, Mary E. Kubiszak, John Herbert
Active agent combinations
Abstract: The novel active compound combinations of extracts from seeds of the neem tree and the active compounds of groups (B) to (F) listed in the description have very good insecticidal and acaricidal properties.
Inventors: Gerhard Baron, Michael Kilian, Frank Rosenfeldt
Ectoparasiticidal Methods and Formulations
Abstract: Provided are novel methods and formulations for topically controlling ectoparasite infestations in animals using spinetoram or a pharmaceutically acceptable salt thereof.
Inventors: Jeffrey Alan Meyer, William Hunter White, Joseph Raymond Winkle
Adjuvant containing polyorganosiloxane and organic solvent for preparing a larvicidal tank mix
Abstract: The present invention relates to a method for controlling insects comprising the steps of preparing a tankmix by mixing a larvicide and a liquid adjuvant, wherein the adjuvant is essentially free of the larvicide and contains at least 1 wt % polyorganosiloxane, and at least 20 wt % synthetic organic solvent; and applying the tankmix on a water surface. The invention further relates to a liquid adjuvant for preparing a larvicidal tankmix, wherein the adjuvant is essentially free of a larvicide and contains at least 1 wt % polyorganosiloxane, and at least 20 wt % synthetic organic solvent. Finally, it relates to a method for preparing said adjuvant, comprising mixing the polyorganosiloxan and the synthetic organic solvent.
Applicant: BASF SE
Inventors: Claude Taranta, Helmut Mueller, Susanne Stutz, Egon Weinmueller, James W. Austin
ANTIBACTERIAL AGENTS: COMBINATION OF A RIFAMYCIN AND A SWITCH REGION INHIBITOR
Abstract: It has been determined that co-administration of a rifamycin and a switch-region inhibitor 1) results in synergistic antibacterial effects, enabling efficacy at low, subtoxic doses, and/or 2) results in a low spontaneous resistance frequency, enabling treatment of high-titer infections without treatment failure due to spontaneous resistance. Accordingly, certain embodiments provide composition comprising a rifamycin and a switch region inhibitor, as well as methods of use thereof.
Filed: February 5, 2013
Inventor: Richard H. Ebright
NANOTECHNOLOGY SYSTEM FOR AGRICULTURAL APPLICATIONS
Abstract: A first aspect of the invention is an agricultural composition comprising nanoparticles, an agrochemical active ingredient in the nanoparticles, and optionally (but in some embodiments preferably) a carrier for the nanoparticles. In some embodiments, the nanoparticles are viral particles or capsids, particularly plant viral particles or capsids. In some embodiments, the carrier comprises an inert or biodegradable carrier (e.g., a solid carrier) to which the nanoparticles are bound or in which the nanoparticles are suspended. In some embodiments, the carrier comprises inert or biodegradable polymer fibers.
Inventors: Steven A. Lommel, Julie Willoughby, Richard Guenther
PESTICIDE COMPOSITIONS EXHIBITING ENHANCED ACTIVITY
Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels are disclosed. In one embodiment, a composition includes at least one pesticide, at least one transition metal salt and least one proteinaceous material. In this embodiment, the composition exhibits enhanced pesticidal activity levels compared to a composition dissimilar only in not having the at least one transition metal salt and the at least one proteinaceous material.
Inventors: Stephen L. Wilson, Lei Liu, James D. Thomas, Raymond E. Boucher, JR., James E. Dripps, Margaret S. Kempe
Abstract: Provided are novel methods and formulations for topically controlling ectoparasite infestations in animals using spinetoram, or a pharmaceutically acceptable salt thereof.
Inventor: Joseph Raymond Winkle
Ribosome structure and protein synthesis inhibitors
Abstract: The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
Assignees: Melinta Therapeutics, Inc., Yale University
Inventors: Thomas A. Steitz, Peter B. Moore, Joyce A. Sutcliffe, Adegboyega K. Oyelere, Joseph A. Ippolito
Abstract: Pest controlling compositions exhibiting enhanced pesticidal activity levels are disclosed. In one embodiment, a composition includes at least one pesticide, at least one proteinaceous material and at least one polymeric material. In this embodiment, the composition exhibits enhanced pesticidal activity levels compared to a composition dissimilar only in not having the at least one proteinaceous material and the at least one polymeric material. Still, alternative embodiment pesticide compositions exhibiting enhanced activity levels are disclosed.
Filed: May 2, 2014
Applicant: Dow AgroSciences, LLC
MAILLARD REACTION INHIBITOR
Abstract: A Maillard reaction inhibitor which effectively inhibits the progress of a Maillard reaction in a living body, can be safely applied without adverse side effects, can be manufactured without any complicated process, a skin anti-aging agent, an anti-diabetic complication agent and foods and beverages using the same. The Maillard reaction inhibitor contains 50 to 90% by mass of polyphenol as an active ingredient. The Maillard reaction inhibitor has a potent Maillard reaction inhibitory activity in a living body and allows for the prevention and improvement of the various dysfunction of protein in a living body. Due to this activity, the Maillard reaction inhibitor suppresses aging and can prevent and/or treat diabetic complications. Furthermore, when the above-described tannin is mixed in foods and beverages containing collagen, it is possible to suppress the Maillard reaction in the foods and beverages to suppress the deterioration of the foods and beverages.
Inventors: Norihisa Nishida, Akifumi Nagatomo, Hideyuki Ito
PESTICIDAL MIXTURES INCLUDING SPIROHETEROCYCLIC PYRROLIDINE DIONES
Abstract: A pesticidal mixture comprising as active ingredient a mixture of component A and component B, wherein component A is a compound of formula (I), in which Q is i or ii wherein X, Y and Z, m and n, A, G, and R, are as defined as in claim 1, and component B is a compound selected from the following insecticides: a), pymetrozine; b). a pyrethroid selected from the group consisting of cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin; c). a macrolide selected from the group consisting of abamectin, emamectin benzoate, and spinetoram; d). a diamide selected from the group consisting of chlorantraniliprole and cyantraniliprole; e). thiamethoxam; f). sulfoxaflor; g). cyenopyrafen. The present invention also relates to methods of using said mixtures for the control of plant pests.
Applicant: SYNGENTA PARTICIPATIONS AG
Inventors: Anke Buchholz, Fabienne Hatt, Alfred Rindlisbacher, Michel Muehlebach
Pest controlling composition
Abstract: A pest controlling composition comprising spinetoram and a cyclic keto-enol compound having an acetyl CoA carboxylase-inhibiting activity as active ingredients.
Assignee: Sumitomo Chemical Company, Limited
Inventors: Yasutaka Shimokawatoko, Emiko Sakamoto, Mayuko Ozawa
Inventors: Jeffery Alan Meyer, William Hunter White, Joseph Raymond Winkle
Methods of Treating Recurring Bacterial Infection
Abstract: The present invention relates to methods of treating a recurring gastrointestinal (GI) infection of Clostridium difficile in a subject comprising administering to the subject an effective amount of the compounds of the present invention.
Applicant: Optimer Pharmaceuticals, Inc.
Inventors: Youe-Kong Shue, Sherwood Gorbach, Pamela Sears
STABLE INSECTICIDE COMPOSITIONS AND METHODS FOR PRODUCING SAME
Abstract: Insect controlling compositions including an N-substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximine compound exhibiting increased stability, along with methods for preparing same, are disclosed.
Inventors: Kuide Qin, Raymond E. Boucher, Jr.
PEST CONTROL COMPOSITION INCLUDING NOVEL IMINOPYRIDINE DERIVATIVE
Abstract: Provided is a pest control composition containing a novel iminopyridine derivative and other pest control agents. Provided is a pest control composition containing an iminopyridine derivative represented by the following Formula (I) and at least one of other pest control agents: [in the formula (I), Ar represents a 5- to 6-membered heterocycle which may be substituted, A represents a heterocycle having a 5- to 10-membered unsaturated bond including one or more nitrogen atoms, and has an imino group substituted with an R group at a position adjacent to the nitrogen atom present on the cycle, Y represents hydrogen, halogen and the like, and R represents any one of groups represented by the following Formulae (a) to (e), (y) or (z)].
Applicant: MEIJI SEIKA PHARMA CO., LTD.
Inventors: Ryo HORIKOSHI, Yasumichi ONOZAKI, Satoshi NAKAMURA, Masahiro NOMURA, Makoto MATSUMURA, Masaaki MITOMI
Dermatological cream-gels containing avermectin compounds
Abstract: Pharmaceutical cream-gel compositions useful for the treatment of a variety of dermatological conditions, disorders and afflictions, in particular of rosacea, contain at least one avermectin compound active principle, and which also contain an oily phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier, the oily phase comprising oils having a melting point below 30° C. and being free of solid fats having a melting point above 30° C., formulated into a physiologically acceptable medium therefor.
Inventors: Fanny Astruc, Sandrine Orsoni, Laurent Fredon


text:
News Film News
Watch an unsettling new clip from St. Vincent's horror film 'The Birthday Party'
Vincent has contributed the film to the anthology movie 'XX', which is out now
'The Birthday' Party, by Annie Clark (St. Vincent)
A new clip from St. Vincent's short horror film The Birthday Party has been shared, as the anthology movie it is taken from, XX, enjoys its release.
The artist – AKA Annie Clark – made her directorial debut with the contribution to XX, with her eight-minute film depicting a child's party that goes wrong.
With XX now in selected theatres and on-demand following its release yesterday (February 17), Clark has unveiled one final teaser for her part in the anthology. As guests file into the party, the camera switches between slow-motion shots of the exasperated main character and someone dressed in a panda costume locking eyes across the room.
Watch the final teaser for XX below.
Speaking to FACT about The Birthday Party, Clark revealed that the tale was somewhat based on a true story – albeit in a "very, very, very, very abstracted" way.
"It's the idea of waking up with a death in the house and making a split-second decision to try and protect your children for as long as you possibly can," she said.
Earlier this week, Clark paid tribute to Prince by dedicating the latest episode of her Beats One radio show, Mixtape Delivery Service, to the late musician.
http://link.brightcove.com/services/player/?bctid=3197839448001


text:
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Can I Be A Company Director If I'm Not An Australian Citizen? (2019 Update)
Find out whether Australia's rules and regulations prohibit non-Australian residents from being appointed as company directors.
Becoming a company director allows you to have great influence over the growth and operation of your business. Typically, a company may have one director or a board directors. But with great power comes great responsibility. All directors have duties and obligations that hold them responsible for managing the company's affairs. If you intend to be a director, you must first understand the rules which surround this process.
A company director is defined in Section 9 of the Corporations Act 2001 (Cth) as someone 'who is appointed to the position of director'.
Who Can Be A Director?
Generally, there are no restrictions on who can be a company director. Unless banned for previous offences, any Australian adult is eligible to be a director. However, there are two legal requirements relevant to the appointment of company directors:
A director must be at least 18 years of age; and
A director must consent to taking on the role and responsibilities of a director.
For proprietary companies, there must be at least 1 director and they must ordinarily reside in Australia. For a public company, there must be at least 3 directors, two of which must ordinarily reside in Australia.
Non-Australian Residents
In contrast, non-Australian residents (otherwise known as foreign residents) do not hold a permanent visa (such as a student visa) nor an Australian citizenship.
Criteria For A Permanent Person or Non-Resident
The number of directors a company can have depends on whether it is a proprietary company (has 'Pty' in its name) or a public company (does not have 'Pty' in its name). For proprietary companies, they must have at least one director residing in Australia. Non-Australian residents can be appointed if more directors are needed. In contrast, public companies must have a minimum of three directors with at least two residing in Australia. Here, a non-Australian resident can also be one of the three who is eligible to be a company director.
Ultimately, a foreign person must establish 'ordinary residence' or Australian residency and must be personally present or ordinarily resident to be appointed a director. More so, there has to be a degree of permanence of the person's residence. Therefore, in some circumstances, a company may appoint one or several foreign directors depending on the type of company and if they meet the above requirements.
Be aware some people may have dual residency that authorises them to have ordinary residence in more than one country at the same time.
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Not just anyone can be a director. There are types of people who are not eligible to direct a company. For a comprehensive list, check out Australian Securities and Investments Commission's Who Can Be A Director.
A director must be at least 18 years of old.
A person must consent to becoming a director.
Non-Australian residents can be directors. But this depends on the type of company and the number of directors the company has residing in Australia.
Before you can be a company director, it is important that you check that all the rules and regulations are being complied with. Otherwise, legal problems can arise, which can negatively affect the company. Are you unsure of your obligations as a company director? Our online lawyer marketplace can connect you with an experienced business lawyer.
Don't know where to start? Contact a LawPath consultant on 1800 529 728 to learn more about customising legal documents and obtaining a fixed-fee quote from Australia's largest legal marketplace.
Fiona Lu
Fiona is a Paralegal working in our content team which aims to provide free legal guides to facilitate public access to legal resources. With an interest in information, media, consumer and employment law, her primary focus is on how technology will affect the future of the legal industry.
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