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https://mmajunkie.usatoday.com/2018/08/john-mccain-dies-remembering-history-ufc-human-cockfighting
Remembering John McCain's imperfect history with MMA
Steven Marrocco
August 26, 2018 4:15 pm ET
MMA was one of the smaller fights in John McCain's political career, but his role in its evolution resonates deeply with industry veterans.
McCain, a Republican senator from Arizona with a history of crossing the political aisle for causes dear to his heart, died Saturday after a long fight with brain cancer. For MMA, he leaves a legacy as an unlikely catalyst for the sport as we know it today.
"If it wasn't for Senator McCain forcing the issue of regulation in MMA, the sport wouldn't exist and flourish as it does today," former UFC co-owner Lorenzo Fertitta told Yahoo! Sports.
Before Sheldon Adelson abused his power to shut MMA out of New York, there was McCain. The UFC's chief antagonist, he infamously used the term "human cockfighting" in 1996 to describe MMA in a letter to all 50 state governors. The ensuing controversy bounced the UFC from cable providers, cutting off its chief revenue stream.
UFC 25th anniversary news conference face-offs video highlights, photos
McCain remembered the horror of watching his first UFC fight. One fighter sat atop his opponent, smashing them in the face, with no referee to intervene.
"That's not a sport," McCain said in 2015. "That's a throwback to the Roman Colosseum."
But McCain's opposition only strengthened the UFC's early proponents. They convened a group of industry veterans to create a set of unified rules that helped MMA get sanctioned in 2000. In 2001, the sport was sanctioned in Nevada, where Fertitta sat on the state's athletic commission before buying the UFC outright.
As MMA grew into a multi-million dollar industry, and McCain's ties to the UFC grew closer, his opposition softened. Although the new rules didn't prevent the scenes that so thoroughly offended him, they helped the sport shed its image of pure barbarism.
Empire State Fistfight: How New York legalized MMA, and why it's such a big deal
Guest column: Joe Lauzon says MMA and "human dogfighting" a poor comparison
"I don't enjoy it as much as I do regular boxing, because that's what I grew up with," McCain said. "But I don't have objections to it now."
Cut to 2014, and McCain stood beside Fertitta, Bellator chief Scott Coker and Bellator fighter Phil Davis, among others, pledging support for a study of fighters' brains. As a chief architect of the Muhammad Ali Act, which increased state oversight of boxers and protected them from onerous contracts, McCain drew no distinction between the plight of the pugilist and the martial artist in the cage.
At the meeting, McCain offered his best wishes to then-UFC champion Jon Jones. He even said he might have tried his hand at MMA if he had the chance.
For those who watched McCain's journey, his death didn't erase memories of the past. But it wasn't enough to overshadow his accomplishments as a patriot. However imperfect his history with MMA, McCain commanded respect.
I had many things to dislike about John McCain. He tried to destroy the sport I loved not because he felt it was right, but because of loyalties to political supporters & money. However I respect the man and his service to our country, his time in a POW prison cannot be forgotten
— Big John McCarthy (@JohnMcCarthyMMA) August 26, 2018
For more on the upcoming MMA schedule, visit the MMA Rumors section of the site.
Photos: Dana White separates UFC fighters


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Home > Posts > Asia Pacific > Ruth's Rankings News Flash! 2019-1: THE Asia/Pac update and other Asia rankings
Ruth's Rankings News Flash! 2019-1: THE Asia/Pac update and other Asia rankings
(11 Mar 2019) The calendar year 2019 rankings' cycle has begun. News Flashes will focus on ranking changes, if any, and new observations. News Flash 2019-1 includes updates to THE Asia/Pac rankings and QS subject rankings.
Who is THE's number one university in Asia/Pac?
What country has the most top ten universities?
On what top ten list will you find Peking U and Xiamen U?
THE released its 320 Best Universities in the Asia-Pacific in a format that allows for no filtering. The methodology uses the same universities and indicators from the world rankings, with the indicators slightly re-weighted. It gives less weight to teaching and more to industry income. The top 100 have individual ranks. The website list includes only the ranks. Click here to see the 2019 list with scores.
News Flash 2019-1 Table1 A below lists the top 10 Asia/Pacific universities. Eight universities from four countries are in all top 10 rankings. Hong Kong leads in 2019 with three of the top 10 universities. Tokyo and Peking rank higher in the world rankings than these regional rankings.
News Flash 2019-1. Table 1B lists the top 25 universities in Asia/Pac for 2019 compared to the 2018 and 2017 rankings and their 2019 World rankings. 27 universities make up the list for the three years. 24 of 2019 top 25 in the region are also the top 25 in the World rankings, with a little re-ordering.
News Flash 2019-1 Table 2.A below compares the percent of institutions by country to the percent in the top 25 for 2019. See Table 2.B for underlying data. Singapore and Japan represent the two extremes. For example, 32% of the universities are Japanese and only 2% are in the top 25. Singapore's two universities, less than one percent of the list, are both in the top 10.
THE published a regional ranking for all of Asia in February 2018 using the regular ranking interface. It has not been updated. The first non-Eastern or Southern Asian institution is Tel Aviv University, coming in at 25. The top nine are on both lists. Table 3 compares three THE Asian rankings with the QS Asian ranking. QS covers only Eastern and Southern Asia. Eight universities are top 10 on all four lists. For fun, I calculated an average rank that puts NUS at the top followed by Tsinghua.
The most interesting THE Asian list I came across highlights the top 10 most beautiful campuses in East Asia. I only visited three of them and was surprised by the inclusion of City U HK, whose main entrance is through a shopping mall. My first trip to China after moving to Singapore was to Xiamen University. It has a lovely campus and I was delighted to see it on the list.
THE Summary and Observations: Universities from China, Taiwan, Malaysia, Indonesia, The Philippines, and Thailand also appear in the Emerging Economies Universities rankings. The same universities rise to the top, in slightly different order. The multiple lists add little to the narrative. What strikes me, as shown in Table 2A above, is the profile for Singapore. With a population of about 5.6 million people, it has two ranked universities and they are both in the top 10. This provides Singapore with bragging rights. The challenge is how to improve the profiles of the four 21st century autonomous government universities. New Zealand, with a population of about 4.8 million people has only one university in the top 10 and eight ranked universities. The star is Hong Kong, with a population of 7.4 million with six universities and four in the top 25. The biggest loser is Japan with only one top ten universities.
CAVEAT: Remember when you read the ranking organization's news releases that they are looking for things to highlight. With little change over time, it is a challenge. What they chose to highlight may not be what is important to you and your organization. Finally, with so many ranking sources for Asian/Pac universities, pick one that has the best methodology to fit your organization, not the one that gives you the highest rankings. That is the one you should follow.
The next News Flash will evaluate QS' new subject rankings and the underlying Academic and Employer surveys that are the basis for the rankings.
Ruth's Rankings News Flash! is written by Ruth A. Pagell, emeritus faculty librarian at Emory University. After working at Emory, she was the founding librarian of the Li Ka Shing Library at Singapore Management University and then adjunct faculty [teaching] in the Library and Information Science Program at the University of Hawaii. She has written and spoken extensively on various aspects of librarianship, including contributing articles to ACCESS – https://orcid.org/0000-0003-3238-9674
This entry was posted in Asia Pacific, University Rankings and tagged Ruth Pagell, THE Asia-Pacific University Ranking 2019, THE Rankings on March 14, 2019 by admin.
‹ National Library launches 'enormous' archive of Australia's Internet Publons partners with Hindawi Limited to improve and speed up the peer review process ›

redpajama_set_name: RedPajamaCommonCrawl


Six years after his last album on Miasmah, Schattenspieler (MIA 013CD/LP, 2010), it's great to find Marcus Fjellström resurrected after several long years spent composing his audio-visual opera Boris Christ. Born out of shattered dreams and an obscured vision of the future, Skelektikon is a delirious yet lucid exploration of the farthest and most conflicted reaches of the heart, teeming with confusion, passion, and ghostly shadows. Being no conventional composer in any way, Marcus stumbles further down his musical domain of detuned orchestral (re-)arrangements and pain-inducing synth passages, arriving at a most unique and personal result. Where Schattenspieler gave way to noir filled alleyways, Skelektikon fills them with paranoia. It's the sound of limbo, of dancing amoebas, of deviant skeletons, nostalgia, and futurism, or quite possibly none of that. Inhabited by the bizarre and the beautiful, Marcus's music is a blurred yet encouraging representation of how you can never trust your own feelings - or eyes and ears for that matter. And yet, you can't shake the idea that the truth is to be found somewhere within this alien language, as delivered to us through the speakers. After the listener opens their eyes after the final track has dissipated, they shouldn't be surprised to find someone or something there, staring at us, in silent and unsettling knowledge. CD version comes in a digipak sleeve; Edition of 350.
Other releases by "marcus fjellstrom"


Congratulations Sadeeka Parker you are our winner… Smaller scaled chandeliers or mini chandeliers are becoming more and more popular. This allows home owners to use these fixtures for more intimate settings as well. For example, having two hanging mini chandeliers on either side of a bed vs. the traditional bedside lamps provides more glamour, interest, and an element of design for master bedrooms. We love this concept and so we decided to do a giveaway with Illumina. All you need to do is LIKE Illumina Lights & SHARE this post. Competition closes on Friday the 18th of October, so get going. Tweeting will get you far in this competition. Tweet [email protected] with this post.
Take a look at how the room chances once the Chandelier has been added.


On a recent trip to San Francisco, I misplaced by Bluetooth headset. Fortunately, I had something Bluetooth waiting for me when I got back, with the Jabra FREEWAY Speakerphone.
We have reported on the initial release of the FREEWAY back in March, and even though it has a clip for the car visor, it can also work on the desk as well. I found that it instantly recognized my Bluetooth-enabled smartphone within mere seconds of being powered on.
Having the three speakers with virtual surround sound was also handy, not to mention it announcing the name of the incoming caller. The ability to have it answered by me saying "Answer" is another added bonus.
Other features included the 14 hours of talk time and 40 days of standby. It is also good for A2DP streaming for playing of music, podcasts, and GPS directions. Another great feature is that it can link up with two Bluetooth devices at the same time.
According to the official web site, the Jabra Freeway is exclusively available at Amazon.com. The price is about $124.94, which might seem like a high price to some, but it is a good price for a Bluetooth speaker of this quality in my opinion. In short, I recommend the product.


You probably noticed that it's been a bit slow here at the blog lately. I've been working furiously to make sure everything was ready for the launch of my new project – a new pet sitting association – the APSE that I've launched with Petsittology owner Joshua Cary. I'm really excited about the APSE – we are off to a great start and it's our goal to make the APSE a new generation of pet sitting organization that promises to give pet sitters, through their membership and active participation, a new voice in shaping the future of the booming pet care industry.
The 49 billion dollar US pet industry is predicted to continue to grow annually by 6% through 2013 (Fast Company Feb 2009). This expansion brings many new opportunities for pet care providers like you and me. One the reasons that I've launched the APSE is because I want to ensure that pet sitters have the support and tools they need to expand their services to meet this growing customer demand. Josh and I see a need for an organization that provides a place for both new and established pet sitters to get the resources and business guidance they need to achieve excellence in their pet sitting business.
At the APSE we won't be simply rehashing the same-old tools and resources currently available for free, but looking to bring something unique and innovative to the pet sitting industry. We want the APSE to be a member-driven organization and, as such, that it will continue to grow and evolve according to the industry needs. We hope to learn from the members as much as they can learn from us.
As well as providing resources and tools for pet sitters we also want the APSE to become an organization that promotes the benefits of pet sitting in the community and recognizes excellence in the pet sitting industry, and connects pet sitting business owners to enable the sharing of knowledge.
At the APSE we plan to leverage cutting edge online technology to ensure that pet sitters are keeping up with the latest business trends and that our member resources are easily accessible. We will be holding regular virtual webinars and conferences that will allow pet sitters to gain the knowledge that they need to succeed on their schedule and at an affordable price.
We are offering three levels of membership with benefits including on-camera video website reviews, professional publicity audio and video creation, a unique pet sitter certification program, and over 150 articles, business forms, and marketing guides that pet sitters can put to immediate use in their business. Members can also connect with their peers in the APSE member lounge to learn from others that have already been successful and seek advice from an advisory board of pet business professionals. Check out all the APSE Member benefits and pricing now.
When you arrive at our membership benefits and pricing page you'll notice that we are celebrating our launch by giving you a special discount when you join before April 30th. If you join in these first two weeks you will save $40 on your annual APSE membership and be part of a very special group – our APSE Charter Members. As one of these action takers you will be recognized with a unique badge to place on your website and a special "Charter Member" banner will be displayed on your pet sitter locator profile. You will forever be seen as one of our founding members.
We will be asking our Charter Members who are with us during our first two weeks of life to give us feedback about what they experience when they step inside our members areas. We'll be listening in our Members Lounge to hear what you like, and what you would like to see added or changed and we'll be taking action to improve the APSE in response to your feedback. Our Charter Members will literally have the chance to shape the future of their APSE. We hope you join us as a Charter Member and have your say!
In the next couple of weeks we'll be announcing a new competition for members only with some great prizes and a special interview with Josh to learn exactly how he and wife Alitia grew NY based Alitia's animals to over six figures in less than 12 months.
For more information, visit the APSE website at http://www.petsittingexcellence.com. Come join us and help us build a world class place just for pet sitters!


I have launched the Inner Circle for Janome Machine Embroidery Enthusiasts that would like to receive instructions, videos, etc. on a regular basis that they can access in the comfort of their own home and learn at their own pace and I called it "The Studio".
This is all you will ever pay each month for as long as you remain a member, you are effectively "Grandfathered In" as a founding member.
Each month you will gain access to a new set of instructions demonstrating techniques that will help you create fantastic unique projects.
Where appropriate, I will also have a video that you can watch and replay so you will see exactly how to master the particular technique.
You will also receive special pricing for all my products as they are released.
I have just come across your ASQ hoop videos. I enjoyed very much. I Could not see any of the designs. (Feather designs) I would love to give that a go. Also could you please tell me the name of the batting that was used.
HI Geraldine, Please help. I have been pondering over what the file names associated with your download patterns mean. Ie. 11 12 15k. Does this relate to to the machine models or are I away off beam by thinking this way. I have a 15000 Horizon.
Geraldine, you are truly going above and beyond ! ?
There is so much content in your videos and your teaching style is very easy to follow. I highly recommend to anyone who's hesitating to join!!
Keep up the good work so we can learn more on how to use this great machine.
We are trying to incorporate different feet each month, is there any one in particular you would like to cover sooner than later.
Which new designs are you looking for, our design sets pop up in an advert in the righthand sidebar, if what you are looking for is not there let me know.
There has only been 1 update for the 15000 in 2 years ( you should have ver2) but you can check on Janome's website for machine update at anytime.
Thanks for your videos. I am a visual person and needs to refer to the videos often. Question please can these videos be saved on a stick or somewhere for future use. This would be a great help to me.
Yes I am like others who did not get much tuition when purchased my 15000.
Unfortunately at the moment because the videos are delivered within the members area and stored in a protected format there is no option to download at this stage.
If there enough interest we may be able to look at making the videos available on a DVD or USB stick in the future.
I am having trouble with video on the D foot. It is stuck loading and has been for days. Other ruffles videos are working fine. Can you help please?
Not sure I understand, the "D" is covered in the 1st video on month 6 along with the "Ruffler Foot", and plays fine this end. Have you tried refreshing the page?
I am so pleased with the Studio Tutorials and free designs I have received each month since joining. I have learned alert so far and can't wait to see what's next. I loved the specialty feet videos. The digitizing will be very helpfull since I am a beginner to MBX. Thanks so much.
Hi, I'm in the USA, I go by Kate. Not an owner of a Janome, but can see value in learning as much as I can about embroidery from every source available. I look forward to inter-acting with everyone.
Fred, as you are aware we are not on Facebook are we missing out on anything ?? Thanks Bob.
Hi Bob, some of the members have introduced themselves and where there from, there have also been a few questions which have been answered, so there is a little bit going on in the group. But anything created by Geraldine for "The Studio" is made available in the members area.
Fred, could you please turn down the background radio it is a bit distracting over Geraldine's voice !! Thanks Bob.
I just joined and I've really enjoyed watching your videos. I've only found three, though — the MC 15000 Introduction, the Mug Rug, and the ASQ hoop videos. Are there any more?
I've owned my 15000 for a little over a year now but still have a lot to learn I think. You do a great job demonstrating and explaining in your videosl Thanks!
What and where are the videos for the 1st month? Are they the ones I mentioned (the MC 15000 Introduction, the Mug Rug, and the ASQ hoop videos)? Also, are there pictures of the Zentangle designs in that collection?
Yes Paula, the Month 1 videos are the ones you refer to and we are organising photos of and will update the Zantangles page in the next few days.
Do you have visa? I do not have a paypal account.
at this time we can only process payments via Paypal, can you setup an account with them?
I seem to be able to get current messages on the facebook page, but I cannot get updates when I login to "The Studio". Other members are talking about "ducks", and Fred says he has posted a missing video in Month 2. I see the butterflies, but nothing beyond that. I'm still hoping I can unzip designs, rather that keep them in a zipped file. I do not know how to send a zipped file to my machine, or to view the design. Besides, I will then have both zipped and unzipped designs, which seems to me like it is complicating the process.
I have replied to you via email to explain that the additional content (ducts etc) are in Month 2, and you will have access on the anniversary of the day you joined.
The reason the design files are zipped is to allow for quicker downloads.
I can get to the site where the three videos are located, however when I try to watch the 15000, the screen remains green,, no pictures, there is audio. What do I need to do???
Where are you located Judy?
feel free to share any questions and your projects within the private FB group.
I am interested in all of the topics that you said that you will cover in the "Studio". I am floundering with the Artistic Edge Cutter 15 so any instruction or help would be terrific. In the future I hope to get the MBX5 software. In the free designs this month I was not able to access the 12 15K designs, the others OK. As Pat Hicks has said there is very little instruction available when you buy a new machine. The videos from you on the 15000 have been most helpful, Thank you.
Watched video on 15000, thanks! When I purchased my 15000, the dealer did not give any lessons with it and I have read manual and trial and error learned what I know. Thank you for the explanations you have given.


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Caribbean & International
SOURCE RADIO
Norton offers menu of measures to ease cost of living woes for citizens
Hughes urges end to bickering between Government and Opposition; Encourages cooperation on national issues
Opposition Chief Whip calls out Speaker again over "biased" treatment of Opposition MPs during Budget debate; Speaker responds
Shuman offers full support for Budget 2023; Chides rest of Opposition over debate contributions
Homeownership to be made much easier for citizens as Govt. maintains zero tolerance on squatting -Housing Minister
Harbour Bridge Management apologizes over F-bomb notice
Guyanese Attorney Chevy Devonish selected for prestigious US Law Firm programme
President urges regional financial sector to mobilize more capital to meet Caribbean's needs
GECOM concerned about persons posing as its workers in Region 1
By News Source Guyana on August 13, 2014
The Guyana Elections Commission has distanced itself from some persons who are posing as GECOM workers in the Region 1 area and who have been going around to residents with the Registration Lists and claiming that they represent the Elections Commission.
Gecom has launched an investigation into the matter and has said it has no such initiative in the area and none of its staff members are involved in such a programme.
According to a statement from the Elections Commission, investigations so far have revealed that the persons involved in the activity are alleged "Community Support Officers" in Mabaruma and Port Kaituma.
The Elections Commission said its probe also found that the persons have been walking around with a letter they claim was written by the Regional Executive Officer of the Region giving them permission to engage in the activity.
The People's National Congress Reform has also raised concern about the issue and has said its foundation has found that the persons are doing campaign work on behalf of the People's Progressive Party and are actually members of the Progressive Youth Organisation.
Similar To This Article
Region 10 Chairman accuses Government of marginalizing region and ignoring regional and local government bodies
Court action restrains Chief Elections Officer from submitting report for declaration; Appeal Court set to hear matter on Friday afternoon
PNC/R plans to meet with GECOM over voters list concerns and LGE
PPP threatens Court action if GECOM probes claims of "dead voting"
APNU+AFC Members and Supporters Picket GECOM for registration and claims and objections
DPP discontinues private criminal charge against GECOM Chair
Norton offers menu of measures to ease cost of living woes for citizens January 28, 2023
Hughes urges end to bickering between Government and Opposition; Encourages cooperation on national issues January 27, 2023
Opposition Chief Whip calls out Speaker again over "biased" treatment of Opposition MPs during Budget debate; Speaker responds January 27, 2023
Shuman offers full support for Budget 2023; Chides rest of Opposition over debate contributions January 27, 2023
Homeownership to be made much easier for citizens as Govt. maintains zero tolerance on squatting -Housing Minister January 27, 2023
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Police offer holiday shopping safety tips
By Tina Patel
TUKWILA -- It's not just crowds that come out during the holiday season. Criminals come out, too.
Remay McNally learned that the hard way.
"Someone grabbed my purse while I was just walking down the street," she says. "It was during the holiday, and they just took off."
Now she uses a little more caution when she hits the stores.
"I put my purse across my body and hold on to it while I'm shopping. I'm always conscious about my purse."
Police say shoppers should be careful with their purses and other belongings this time of year. But they say that's not enough.
"Very seldom do we see people individually victimized or robbed," says Tukwila police spokesman Mike Murphy. "It's much more common to have your car prowled, after you've put your packages in."
Many shoppers already take care when they have bags full of holiday gifts. Marcus Weisse says he puts a black blanket over his bags. Peg Beard puts everything in the trunk.
But police say some criminals sit in the parking lots, waiting for shoppers to drop off bags and go back into stores.
"Unfortunately, they have become more sophisticated," says Murphy. "They're watching you, watching the kind of bags you've got."
He says you should leave right after you've done your shopping. If you can't, he advises moving your car.
"Hide the packages in the trunk and then move to another part of the parking lot."
He says Tukwila police will make their presence known around Southcenter Mall this holiday season.
"You're going to see a lot more officers, more in cars, we're going to be on bicycles, we're going to be on foot."
But he says shoppers still need to be aware of what's going on around them, if they want to have a happy and safe holiday.


The surface is more porous, and cleaning agents that work on polished granite don't always work on honed. This countertop had mineral buildup and streaking from the previous cleaning agents, but I've substantially restored it in just a few cleanings. Experience and expertise matter!


DURHAM, NC — Community Investment Network (CIN) will host its 2014 National Conference at the Sheraton Imperial Hotel and Conference Center in Durham, North Carolina, October 2-5. "Coming Full Circle" is the theme of the 10th anniversary conference. The public is invited to participate in the conference to learn more about the impact of giving circles and how CIN members are working to transform communities.
For a decade, CIN has charted new paths in philanthropy by mobilizing grant-making giving circles composed of grassroots givers and donors of color. Giving circles are a way for people to pool resources and invest time, talent and treasure to build community and invest in creating social change. Cultivating over 200 members and 16 giving circles across nine states and growing, CIN carries a mission to inspire, connect and strengthen African Americans and communities of color to leverage their collective resources and create the change THEY wish to see.
CIN Founder Darryl K. Lester and Linetta Gilbert, a longtime champion of community-led philanthropy, are the conference's honorary co-chairs. The 2014 conference is set to provide an invigorating mix of fellowship and learning, with a focus on stories of impact. Plenary and breakout sessions will focus on why giving circles are a powerful vehicle for philanthropy and civic engagement, what giving circles across the country are doing and how to start and sustain a giving circle. Conference sessions will also explore the intersection of faith and generosity, initiatives focused on Black boys and girls and children of color, cultivating the next generation of givers, and more.
Register and learn more about the CIN 2014 National Conference at thecommunityinvestment.org. An early-bird special provides discounted registration rates through June. Giving Circle Coordinator Tony Pigford is available at tony@thecommunityinvestment.org to answer questions about membership and the conference.
CIN is currently seeking sponsors for its 10th anniversary conference. Inquiries about sponsorships can be sent to Valaida Fullwood, interim Executive Director, at valaida@thecommunityinvestment.org.


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Nominations Considered During the Second Session of the 106th Congress ...
Por United States. Congress. Senate. Committee on Environment and Public Works
Y 4.P 96/10:
FED - DOCS S.HRG.106-745
S. HRG. 106–745 NOMINATIONS CONSIDERED DURING THE SECOND
SESSION OF THE 106th CONGRESS
COMMITTEE ON ENVIRONMENT AND PUBLIC WORKS
ONE HUNDRED SIXTH CONGRESS
BOB SMITH, New Hampshire Chairman - JOHN W. WARNER, Virginia
MAX BAUCUS, Montana JAMES M. INHOFE, Oklahoma
DANIEL PATRICK MOYNIHAN, New York CRAIG THOMAS, Wyoming
FRANK R. LAUTENBERG, New Jersey CHRISTOPHER S. BOND, Missouri
HARRY REID, Nevada GEORGE V. VOINOVICH, Ohio
BOB GRAHAM, Florida MICHAEL D. CRAPO, Idaho
JOSEPH I. LIEBERMAN, Connecticut ROBERT F. BENNETT, Utah
BARBARA BOXER, California KAY BAILEY HUTCHISON, Texas
RON WYDEN, Oregon
LINCOLN CHAFEE, Rhode Island
DAVE CONOVER, Staff Director
TOM SLITER, Minority Staff Director
Baucus, Hon. Max, U.S. Senator from the State of Montana .............
Lautenberg, Hon. Frank R., U.S. Senator from the State of New Jersey ...........
Smith, Hon. Bob, U.S. Senator from the State of New Hampshire ...
Thomas, Hon. Craig, U.S. Senator from the State of Wyoming ..........
Wyden, Hon. Ron, U.S. Senator from the State of Oregon ....
Biden, Hon. Joseph, U.S. Senator from the State of Delaware ............
Bracy, Terrence L., Chairman, Board of Trustees for the Morris K. Udall
Scholarship and Excellence in National Environmental Policy Foundation ..
Eberhard, Eric D., nominated by the President to serve as a Member of
the Board of Trustees for the Morris K. Udall Scholarship and Excellence
in National Environmental Policy Foundation
Committee questionnaire ......
Senator John McCain ........
Terrence L. Bracy ...........
Prepared statement ........
Response to additional question from Senator Graham .......
McCabe, W. Michael, nominated by the President to serve as Deputy Admin-
istrator of the Environmental Protection Agency
Committee questionnaire
Letter, Office of Government Ethics .................
Prepared statement
Responses to additional questions from:
Senator Crapo .................
Senator Graham .............
Senator Lautenberg ........
Senator Smith .........
Senator Thomas ......
Resume, W. Michael McCabe ...........
Baucus, Hon. Max, U.S. Senator from the State of Montana ..
Bond, Hon. Christopher S., U.S. Senator from the State of Missouri
Hutchison, Hon. Kay Bailey, U.S. Senator from the State of Texas
Lieberman, Hon. Joseph I., U.S. Senator from the State of Connecticut ...........
Reid, Hon. Harry, U.S. Senator from the State of Nevada .................................
Smith, Hon. Bob, U.S. Senator from the State of New Hampshire .....................
Voinovich, Hon. George V., U.S. Senator from the State of Ohio .............. ...... 83,
Warner, Hon. John W., U.S. Senator from the Commonwealth of Virginia .......
Page WITNESSES Aidala, James V., nominated by the President to be Assistant Administrator
for the Office of Prevention, Pesticides and Toxic Substances, Environmental Protection Agency
81 Committee questionnaire .......
135 Letter, Environmental Protection Agency ......................................................
144 Prepared statement ............ Responses to additional questions from: Senator Baucus ....
130 Senator Graham .......
127 Senator Hutchison ............
133 Senator Smith .......................
............... 126, 146 Campbell, Arthur C., nominated by the President to be Assistant Secretary for Economic Development, Department of Commerce
Frist, Hon. Bill, U.S. Senator from the State of Tennessee ...
Robb, Hon. Charles, U.S. Senator from the Commonwealth of Virginia ..........
Roberts, Hon. Pat, U.S. Senator from the State of Kansas .....
70 Thompson, Hon. Bennie G., U.S. Representative from the State of Mississippi Wamp, Hon. Zach, U.S. Representative from the State of Tennessee Wong-Rusinko, Ella, nominated by the President to be Alternate Federal Co-Chair of the Appalachian Regional Commission .... Committee questionnaire .......
.............. Letters:
Appalachian Regional Commission ........
McConnell, Hon. Mitch, U.S. Senator from the Commonwealth of
Kentucky ............
Wong-Ruskinko, Ella, to Senator McConnell ........
Nash, Bob, Assistant to the President and Director of Presidential
Personnel ................
Prepared statement ...........


Auction closes on Tues 10th June at 20:00 GMT (That's tomorrow btw).
OP has a right to add in a BIN for 1.1 BTC.
I am still waiting for a response from a PM Buy it now offer, If they do not want it or I don't hear from them soon, I will consider them sold to s1lverbox.
In either case, Please consider them SOLD.
That, wasn't clear. Maybe for future make this more clear in the thread and all bids and buy it now's should be within thread not PM.
I cannot be sure that is not just your "word".
As this : "Possible Buy it now in progress as per my terms in op, Update soon." is not equal to SOLD.
maybe it's juts me. Anyway, 30 minutes left.
But I said my last post just to keep everyone informed.
Well, thanks for the offer and kind words.
I will not sell anything here again.
Check out my previous auctions, I get shot down for not doing what other people want, It's my auction!
I will follow through this one then thats it.
Don't beat yourself up - your auction - you have the right to accept a BIN or let the auction run till 8pm - if you say you took a BIN I wont be upset - but it's your auction.
I just won't run auction again, I am just fed up of the BS I have to fight just to sell stuff honestly and quickly, I will just run a "sale" and deals can be worked out there.
I will stick with the PM offer of buy it now, Consider closed.
Auction closed with BUT IT NOW offered, See op.
Thank you every one for auction. Shame that i didn't Bin it first but that's how this works.
OP your auction and your rules but for future keep everything in thread. As this PM is just joke for others. You have PM but keeping this to yourself and waiting without info. And later calling this "consider as sold"
Actually, I do see your point, But I did not say "no PM bids" I see some people do, Now I know why.
Shame that i didn't Bin it first but that's how this works.
I actually thought yesterday that 1.1 for the 3 was a really good deal in-hand in-uk. Me too should have just offered it. I wouldn't want to part with my 6 S1s for that price right now.
Just shows these things are holding their value even with the diff increases.


Download Free Hope For Today Book in PDF and EPUB Free Download. You can read online Hope For Today and write the review.
No mother ever expects to grieve the death of her child before or immediately after the child is born. Butthe National Institute of Environmental Health Sciences reports that as many as 31 percent of all pregnancies end in miscarriage, stillbirth, or infant loss. When the unthinkable happens, where do women turn for help? Written from the perspective of one grieving mommy to another, Hope for Today, Promises for Tomorrow is a ten-week study that will encourage and challenge women to delve into a deeper understanding of God's Word. As women engage in biblical teaching, they will learn to embrace God's promises of love, goodness, purpose, comfort, peace, refinement, restoration, hope, and eternity. "Hope for Today" verses peppered throughout each chapter, journaling cues, prayers, and the stories of other women who have experienced loss will help readers move from grieving in silent solitude to living life in the richness of God's love. While other books suggest a one-size-fits-all method for grief management or focus on understanding specific causes of child loss, Hope for Today, Promises for Tomorrow offers comfort for the reader, whatever her situation, by helping her focus on the light of the ultimate Promise, the hope of a Savior, Jesus Christ.
Hope is beyond faith. Faith is conviction of truth, assurance in Christ Jesus and total reliance upon Christ for salvation (Ephesians 2:8). "Faith is the substance [confidence, being sure] of things HOPED for and the evidence [certain] of [what we do not see] things not seen" Hebrews 11:1. Faith is having confidence in God's plan while Hope anticipates, expects, ponders, and yearns for it. Annette Herndon is a Christian recording artist, songwriter, pro-life activist, author, conference speaker/organizer, television host, wife and mother who has a heart for God and a passion for prayer that will move you out of your comfort zone and bring you face to face with your heavenly father. Annette stirs emotions, touches hearts, and impacts lives and she comes to you with a ministry of the Holy Spirit that will leave you encouraged and ready to experience a more intimate relationship with God.
A low-cost outreach edition of the Gospel of John with application notes throughout, as well as guides to the Apostles' Creed and the Lord's Prayer.
As the sun comes up every morning to give light to a dark world, we are reminded that God's mercies and compassions are new every morning (Lam. 3:22, 23). The sunrise also assures us that we can look to God's Word each day and find light for a world in spiritual darkness. This collection of daily devotions is intended to give hope and help with assurance that God has the answers to every situation and season of life. I want to acknowledge everyone who helped make this book a reality. I am especially thankful for the original typing, manuscript preparation, and assistance by WestBow staff, and the prayer and financial support of my church, Cornelius Chapel. I also thank all who encouraged me in this project. I want to acknowledge everyone who helped make this book a reality. I am especially thankful for the original typing, manuscript preparation, and assistance by WestBow staff, and the prayer and financial support of my church, Cornelius Chapel. I also thank all who encouraged me in this project.
God's Word is Truth. It is the very character and essence of God in written form. As you study the Scriptures with an alert mind and a receptive heart, you will be strengthened, empowered, and filled with the hope that comes through a loving and growing relationship with Jesus Christ. We are who the Bible says we are, we can have what it says we can have, and we can do all that it promises we can do. This is the heart of the message that Joel and Victoria Osteen share every week with an audience of millions around the world via television, the internet, and worship events. Their practical, uplifting message of hope found in Christ has changed the lives of individuals, impacted families, and literally transformed communities. They place an incredible value on the principles of the Bible, which have a miraculous, life-changing impact on anyone who is willing to study and obey its truths. The Hope for Today Bible is filled with insights, notes, and encouragements from Joel and Victoria designed to help you grow deeper in your walk with God. It also includes specific verses that you can pray over your relationships, your children, your finances, and your health. In addition, "HopePoints" are key words and supporting scriptures related to topics such as favor, forgiveness, anger, depression, loneliness, self-control, and many more. This Bible is presented in the New Living Translation, which combines phenomenal scholarship and textual accuracy with clear, easy-to-understand contemporary language. The Bible will come alive and become clear like never before.
The purpose of the book is to bring the word of God into the believers life on a daily basis in and up lifting form, a daily devotional to give them hope from the word of God, The Holy Bible. To survive in today's world. Words to exhort and comfort not to condemn. Words to help you stay on the right path daily to bring us to Gods expected end. Jer 29:11 11 For I know the thoughts and plans that I have for you, says the Lord, thoughts and plans for welfare and peace and not for evil, to give you hope in your final outcome. AMP Let God be your guide to your expected end.
Hope for Today, Al-Anon's newest daily reader brings fresh insight and much-needed support to anyone affected by a loved one's addiction.


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Stella McCartney pays tribute to George Michael in Paris Fashion show
The legendary popstar died of natural causes
Sophie McCoid
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Stella McCartney paid a touching tribute to George Michael in her Paris Fashion show.
Stella - The daughter of Paul and Linda McCartney - had her catwalk models sing and dance at the culmination of her autumn/winter collection show on Monday.
It was a fitting tribute to George, who famously cast five of the 90s' biggest supermodels - Naomi Campbell, Linda Evangelista, Tatjana Patitz, Christy Turlington and Cindy Crawford - in his Freedom 90 music video.
George Michael died of natural causes, inquest finds
(Image: AP)
It was followed up two years later when supermodels including Eva Herzigova, Linda Evangelista and Tyra Banks then appeared in his Too Funky video.
As her show ended the models danced along to George's iconic song Faith, as they were joined by more and more models.
Full list of winners at the 2017 Brits
They chanted "Love, faith" as they walked off the stage before Stella walked out to thank the crowd by blowing kisses their way.
George was found dead at his home on Christmas Day, aged just 53.
It was announced on Tuesday that a coroner had ruled his death as natural causes.
Oxfordshire's senior coroner Darren Salter said in a statement: "Inquiries into the death of George Michael have been concluded and the final post mortem report received.
Generous George Michael gave TV couple £15,000 for IVF bid
(Image: Chris Radburn/PA Wire)
"As there is a confirmed natural cause of death, being dilated cardiomyopathy with myocarditis and fatty liver, the investigation is being discontinued and there is no need for an inquest or any further inquiries."
The coroner added: "No further updates will be provided and the family requests the media and public respect their privacy."
Incredible pictures of Liverpool's historic Scottie Road over the years
NostalgiaSo much history is packed into this stretch of road just outside the city centre
Wirral's most wanted criminals who police are urgently trying to track down
WirralThese men remain on the run from officers


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Salman Khan's Sultan, Rajinikanth's Kabali top the Google trends 2016
Salman Khan's Sultan, Rajinikanth's Kabali top the Google trends 2016
Actors Sushant Singh Rajput and Disha Patani who starred in MS Dhoni: The Untold Story ruled the Bollywood leads chart for 2016.
By: Express Web Desk | New Delhi |
Bollywood superstar Salman Khan with his blockbuster film Sultan captured the peak position among top trending movies followed closely by Thalaiva Rajinikanth's massive hit Kabali.
Google India has released the 2016 recap of trending stuff in Bollywood and the entertainment world, and the results are not really surprising. Ofcourse, because it includes some of the biggest films and stars that hogged the Google search this year.
Bollywood superstar Salman Khan with his blockbuster film Sultan captured the peak position among top trending movies followed closely by Thalaiva Rajinikanth's massive hit Kabali. Shahid Kapoor starrer Udta Punjab, Akshay Kumar's Airlift and Ranbir Kapoor-Anushka Sharma's controversial film Ae Dil Hai Mushkil also made it to the Top 5.
A still from Airlift starring Akshay Kumar and Nimrat Kaur.
Among the Bollywood leads, power packed performance by Sushant Singh Rajput and Disha Patani not just won them accolades but the duo also emerged on the top trending charts of male and female Bollywood stars.
Check out all the trends here.
1. Top Trending Searches
Sultan, Kabali, Udta Punjab
A still from Udta Punjab staring Shahid Kapoor.
2. Top Trending People
Disha Patani, Urvashi Rautala, Pooja Hegde
3. Top Trending Movies
Sultan, Kabali, Udta Punjab, Airlift, Ae Dil Hai Mushkil, Sanam Re, Sairat, Rustom, Housefull 3, Mohenjo Daro
A still from Ae Dil Hai Mushkil starring Ranbir Kapoor and Anushka Sharma.
4. Top Trending Bollywood Actor (Male)
Sushant Singh Rajput, Kabir Bedi, Harshvardhan Kapoor, Pulkit Samrat, Salman Khan, Arshad Warsi, Suraj Pancholi, Anupam Kher, Ranveer Singh, Vicky Kaushal
A still from MS Dhoni: The Untold Story starring Sushant Singh Rajput and Disha Patani.
5. Top Trending Bollywood Actor (Female)
Disha Patani, Urvashi Rautela, Pooja Hegde, Mandana Karimi, Urmila Matondkar, Nimrat Kaur, Vaani Kapoor, Nora Fatehi, Kiara Advani, Saiyami Kher.
More from the world of Entertainment:
With 2017 just days away, it would be interesting to see how the Google trends change in the new year.
For all the latest Entertainment News, download Indian Express App.


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HomeAnother Monday Quiz – Try It If You Dare!
Another Monday Quiz – Try It If You Dare!
May 13, 2013 May 13, 2013 fasab Factoids, Questions, Tests, Unusual1918, 20 million people, Andie McDowell, animal, 'clean' animal, Baby Gays, beach, Bill Murray, break the sound barrier, British, Catgut, challenge, Chomolungma, collective noun, commercial aircraft, country, Craft of the Wise Ones, declaration of independence, disease, Dixon, education, Entertainment, female, first words, fruit machine, Glabella, God, Groundhog Day, high school, Illinois, july 4th, lakes, Land of Enchantment, largest library, lifeguard, male, Mexico, Misc, Miscellaneous, Name, Noah, Pennsylvania, People, phonograph, Punxsutawney, questions, quiz, quizzes, Random, second year, sophomore, Statue of Liberty, student, tablet, test, tests, the Ark, the world, Thomas A Edison, Tibetans, Tooth Fairy, Unicorns, university, US English, US president, US state, Washington DC
What better way to start of the week than with a quiz?
Okay, okay, so there are better ways, but this is the way we're doing it here.
I think some of the questions are pretty tough this week, but if you are up for a challenge please have a go at them.
As always the answers are waaaaaaaaaaaaaaaay down below, but NO cheating!
Q 1: From what animal do we get Catgut?
Q 2: What country has more lakes that the rest of the world combined?
Q 3: What is the collective noun for a group of Unicorns, should such a thing exist?
Q 4: How many of each 'clean' animal did God tell Noah to take into the Ark?
Q 5: How many people signed the Declaration of Independence on July 4th?
Q 6: What is the name that means "Craft of the Wise Ones"?
Q 7: What is printed on the tablet being held by the Statue of Liberty?
Q 8: The largest Groundhog Day celebration is held in Punxsutawney, Pennsylvania, made famous by the film of that name starring Bill Murray and Andie McDowell. But what date is Groundhog Day?
Q 9: By what name is the Tooth Fairy known in Mexico?
Q 10: What former U.S. president worked as a lifeguard in his youth at a beach near Dixon, Illinois and saved over 77 lives?
Q 11: What was the only commercial aircraft that able to break the sound barrier?
Q 12: They were originally called Baby Gays. What do we know them better as?
Q 13: What were the first words that Thomas A. Edison spoke into the phonograph? (Now you know this, even you think you don't)
Q 14: What disease killed over 20 million people worldwide in 1918?
Q 15: Used in US English to describe a student in the second year of study at high school or university, what does the word "sophomore" literally mean?
Q 16: The British call them a fruit machine, but what are they known as elsewhere?
Q 17: What US State is known as "Land of Enchantment"?
Q 18: The Tibetans call it Chomolungma. What do we know it better as?
Q 19: The vast majority of people, male and female, have a Glabella, but what is it?
Q 20: The largest library in the world is located in Washington D.C. What is its name?
A 1: Catgut comes from sheep not cats.
A 2: Canada has more lakes that the rest of the world combined.
A 3: A group of Unicorns is called a blessing.
A 4: According to Genesis 7:2, God told Noah to take 14 of each kind of 'clean' animal in to the ark.
A 5: Only two people signed the Declaration of Independence on July 4th, John Hancock and Charles Thomson. Most of the rest signed on August 2, but the last signature wasn't added until 5 years later.
A 6: Witchcraft
A 7: July IV, MDCCLXXVI
A 8: Groundhog Day is on February 2nd
A 9: In Mexico the Tooth Fairy is known as the Tooth Mouse, which takes the tooth and leaves treasures in its place
A 10: Ronald Reagan
A 11: The Anglo-French manufactured "Concorde".
A 12: Q-Tip Cotton Swabs
Q 13: What were the first words that Thomas A. Edison spoke into the phonograph? (Now you know this, even if you think you don't)
A 13: The first words that Thomas A. Edison spoke into the phonograph were, "Mary had a little lamb."
A 14: The flu pandemic of 1918 killed over 20 million people
A 15: "wise moron."
A 16: A slot machine.
A 17: New Mexico is known as the "Land of Enchantment"
A 18: Mount Everest
A 19: The space between your eyebrows is called the Glabella
A 20: The Library of Congress
← Are These Dumb Politicians And Bureaucrats Trying To Make America A Better Place Or Just Trying To Destroy It!
Did You Know? More Random Facts From Fasab's Files →
10 thoughts on "Another Monday Quiz – Try It If You Dare!"
Kanerva says:
I'm mortified 4/20. My unicorn collective is a stampede! Great quiz 🙂
BTW, in Australia slot machines are called pokies (that was one of my 4 correct answers 🙂 )
fasab says:
Good for you for trying it. I did say it was a difficult one. I love the term "pokies" maybe that will be a future question 🙂
Under 50% this week.
It was a tough one.
Only 8, all in the 2nd half except for the date on the Statue of Liberty. OUCH! (Unless you consider #10 to be in the first half – which I guess it is. Dixon was VERY proud of its' son in the 1980s, and made sure the rest of the state heard about it ALL THE DANG TIME! 😀 )
And please, PLEASE tell me why we need a term for the space between your eyebrows? I mean, the only time it's important is when there's hair there, and the term "unibrow" is just so much easier!
You make a good point, there are far too many words already and yet we keep adding to the total instead of deleting. And so we have a word for the space between eyebrows which is probably only ever used in quizzes!!!
Only 5 of 20 today. I knew Canada had more lakes than anywhere else, Groundhog Day is Feb. 2, the influenza pandemic, slot machines & the Library of Congress. I thought it said something about being a gift from France on the tablet at the Statue of Liberty & I thought Edison's first words were something about "Come here, I need you."
You didn't do too bad at all. That was a tough bunch of questions.
Wow, some of these were tough! And no, I apparently did not know the first words Edison spoke into the phonograph. Only 6 out of 20 for me.
I think you did okay considering that this was a tough lot, but we dare to go where no one has gone before 😉 .
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The Trail of Tears and Its Long-Term and Short-Term Effects
PHIL WHARTON
The Trail of Tears describes the routes taken by five Native American tribes after they were forced from their homes by the United States government. Beginning in 1831, tens of thousands of men, women and children were forced to move west from the Deep South to what is now Oklahoma. The motivations for this forced removal, and subsequent developments in the five tribes' homelands, highlight the magnitude of the trail's historic importance.
What Led Up to the "Indian Removal"
Immediate Gains and Losses
The Removal and the Development of Slavery
Lasting Effects
1 What Led Up to the "Indian Removal"
The "Indian Removal" of the early 19th century was the result of persistent pressure on and by successive United States governments. The Cherokee, Chickasaw, Choctaw, Muscogee Creek and Seminole peoples inhabited large areas of land which became increasingly financially valuable. As the land became more valuable, the states that included it put pressure on the federal government to make it available to them. This increasing pressure eventually led to the Indian Removal Act of 1830.
2 Immediate Gains and Losses
The terms "Trail of Tears" and "The Place Where They Cried" refer to the suffering of Native Americans affected by the Indian Removal Act. It is estimated that the five tribes lost 1 in 4 of their population to cholera, starvation, cold and exhaustion during the move west. The United States government, meanwhile, gained millions of square miles of territory, and put an end to the tribes' decades of legal and military attempts to protect their lands.
3 The Removal and the Development of Slavery
The Indian Removal Act freed up land to be farmed for the most important cash crop in the Deep South: cotton. Cotton production in the South rose from almost none in 1787 to 3.6 million 500 pound bales by 1860. This explosion in production depended on an increase in the numbers of slaves to harvest the cotton. The Southern economy's reliance on slavery, and increasing Northern opposition to it, would eventually lead to secession of 11 Southern states from the Union, and eventually to the American Civil War.
4 Lasting Effects
The tribes on the Trail of Tears were described as the "Civilized Tribes" because they had largely agreed to live peacefully alongside European settlers, and had adopted settler culture as it helped with co-existence. That the government forcibly removed them afterward led to an abiding lack of trust between the tribes and the United States, and subsequent laws, from the Dawes Act which led to massive acquisition of native lands by European speculators, through the Termination of the Reservations in the 1960s, have -- it can be argued -- ensured this alienation is still felt today.
1 PBS: Indian Removal
2 Teachinghistory.org: A Trail of 4,000 Tears
3 The New York Times: When Cotton Was King
4 History Today: Native Americans and the Federal Government
Based in Newcastle upon Tyne, Phil Wharton has been editing and contributing to magazines and newspapers since 2001. His articles have appeared in "Bread and Roses" magazine and "Industrial Worker." Wharton holds a Bachelor of Arts in humanities from Manchester Metropolitan University, an NCTJ Certificate of Journalism and is currently researching for a PhD in politics at Durham University.
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BOSTON (Feb. 10, 2014)--Reinforcing the need to look beyond genomic alterations to understand the complexity of cancer, researchers from Dana-Farber/Boston Children's Cancer and Blood Disorders Center report that a normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia (AML), to promote progression of the disease. This molecular partnership also promotes AML cells' resistance to treatment with FLT3-blocking drugs, potentially explaining the relatively poor showing of FLT3 inhibitors in multiple clinical studies. In an animal model of AML, treatment with a combination of FLT3- and SYK-inhibiting drugs was significantly more effective than treatment with either drug alone.
The findings, published Feb. 10 in the journal Cancer Cell, raise hopes that treatment strategies that focus on both enzymes simultaneously could help bring molecularly targeted treatments to AML, a common blood cancer. The study also may have broader implications for how clinicians approach the development of such treatments and understand mechanisms behind resistance to treatment in other cancers.
Approximately 14,600 Americans are expected to be diagnosed with AML this year; children account for about 18 percent of patients. The overall outlook for AML patients is mixed; while the majority of patients with AML achieve remission with treatment, many relapse. The cancer cells of some 20 percent of adult and 15 percent of childhood AML patients harbor a genomic alteration called FLT3-ITD, in which segments of the FLT3 enzyme are duplicated again and again, making the enzyme overactive.
"Patients whose AML cells express FLT3-ITD are among the highest risk group of patients with AML," says the study's senior author, Kimberly Stegmaier, MD, of Dana-Farber/Boston Children's Hematologic Malignancies Center. "Their AML is particularly difficult to treat."
FLT3 is a kinase, a molecular switch that routs signals for growth, division and other processes within cells. Many cancers harbor mutations or other alterations that leave kinases stuck in the "on" position. This knowledge laid the foundation for the targeted cancer treatment revolution inaugurated by imatinib (Gleevec®), which has made another blood cancer, chronic myelogenous leukemia, a controllable, chronic disease for many patients.
However, patients with AML have not yet benefitted from that revolution. Researchers and pharmaceutical companies are actively working on FLT3 inhibitors, but to date these efforts have been hampered by low efficacy and concerns about drug resistance.
In 2009, Stegmaier's laboratory discovered that SYK, a kinase that had attracted attention for its role in other malignancies, could be a potential drug target in AML. Unlike other cancer-associated kinases, SYK rarely undergoes mutations or other genomic alterations in cancer cells, remaining in its normal or "wild-type" form.
To better understand SYK's role in AML, in the current study, Stegmaier, lead author Alexandre Puissant, PhD, of Dana-Farber/Boston Children's, and their collaborators screened AML cell lines to reveal the full scope of the enzyme's molecular interactions. They found evidence of strong interactions between wild-type SYK and mutated FLT3, in particular FLT3-ITD.
"We wanted to understand the cooperative oncologic effects by which SYK contributes to AML," Stegmaier explains. "The concept of a normal enzyme aiding a mutant one has not yet been widely explored, and so we were both surprised and pleased to see FLT3-ITD come up as a high-priority hit in our screens."
Through experiments in cell lines, primary patient samples and animal models, the research team found that SYK and FLT3-ITD's interactions are a key ingredient in the progression of myeloproliferative disorder, a related blood cell disorder, into AML. AML cells' continued growth after turning malignant also relied on these interactions.
Additionally, the team found that SYK's hyperactivated form can promote resistance to the FLT3-targeting drug quizartinib (AC220, Ambit Biosciences). They could overcome this resistance with a combination of quizartinib and the SYK-blocking molecule PRT062607 (Portola Pharmaceuticals), significantly increasing survival and reducing signs of disease in an FLT3-ITD AML mouse model.
Highlighting their findings' clinical relevance, the researchers found strong SYK activity in cells from FLT3-ITD AML patients. The cells were also highly sensitive to SYK inhibition.
"These data affirm that SYK is an important target in AML," Stegmaier states. "They also suggest that interactions between oncologic kinases and SYK or other wild type enzymes may contribute to resistance of kinase inhibitors more broadly."
Stegmaier notes that over the course of this research, the team has developed a suite of tools that could prove invaluable for future clinical studies of treatments with SYK inhibitors or SYK inhibitors in combination with FLT3 inhibitors.
"We have not only identified SYK as a candidate treatment target in AML, but we have also identified a specific population of patients with AML more likely to respond to SYK inhibitors: patients with FLT3 mutations," she says. "Moreover, we have developed tools for identifying patients with high levels of SYK and FLT3 activation and can monitor these two targets while patients are receiving treatment. Predictive biomarkers of response are becoming increasingly important in the development of effective clinical trials of targeted therapies."
The study was supported by the National Cancer Institute (grant number R01CA140292), the American Cancer Society, the Starr Cancer Consortium, Project Cupid and One Mission, the Swedish Research Council and Swedish Cancer Society and the Leukemia and Lymphoma Society.
The Dana-Farber/Boston Children's Cancer and Blood Disorders Center brings together two internationally known research and teaching institutions that have provided comprehensive care for pediatric oncology and hematology patients since 1947. The Harvard Medical School affiliates share a clinical staff that delivers inpatient care at Boston Children's Hospital and outpatient care at the Dana-Farber Cancer Institute's Jimmy Fund Clinic. Dana-Farber/Boston Children's brings the results of its pioneering research and clinical trials to patients' bedsides through five clinical centers: the Blood Disorders Center, the Brain Tumor Center, the Hematologic Malignancies Center, the Solid Tumors Center, and the Stem Cell Transplant Center.


You may think modern cars incorporate enough high tech security features to deter thieves but the truth is somewhat different. Although car theft numbers have dropped significantly over the last ten years, the better part of 70,000 cars are still stolen each year.
Greater London is the UK's 'theft hotspot' with prestige cars most at risk – they filled the top ten of cars stolen and recovered in 2015 with no less than three Range Rover variants appearing on the list. If you're thinking of running one as your next car the following tips may be of particular interest.
A combination of taking basic security steps and perhaps investing in more security hardware could help ensure your car stays where you parked it.
Check it's locked properly – remote control 'plippers' can make us complacent when locking the car. A quick 'plip' with the key and walking away may not be enough; it's worth checking for certain the car has actually locked itself.
Thieves can use remote control blockers to interfere with the radio signal transmitted to the car by your key fob so stopping it locking; if you're in any doubt the car is locked check it manually.
Leaving unlocked and engine running – never leave your car unlocked and unattended. Even popping back indoors for a few seconds to fetch something while leaving the car unlocked is all the time an opportunist thief needs to jump in and drive your car away.
Leaving the engine running in your unattended car is asking for trouble – and it's illegal.
Parking carefully – try and take the time honoured advice of parking in a well lit street or car park, preferably amongst other vehicles. Thieves much prefer to work in dingier conditions rather than under strong street lighting.
Turn the front wheels towards the kerb when parking on the street or towards another car when using a car park. It makes it harder for the thief to move your car; likewise driving front first into a driveway or parking space makes it harder to quickly drive your car away as reversing will be involved.
Visual deterrents – investing in a visual deterrent such as a steering wheel lock can help. This extra level of security may make a thief think twice about trying to steal your car; they usually give themselves mere seconds to break into a car, so anything that could cause delays might dissuade them.
Valuables on display – don't leave tempting items in clear view such as briefcases, cameras, sat navs or laptops. Even a plastic bag with basic shopping could tempt a thief to break in and see what's inside. Take valuables with you or at least stow them out of sight in the boot.
Trackers – it's worth fitting a Thatcham approved one to a prestige car; if the car is stolen the police can more easily find it. Advertising the fact the car has a tracker fitted will help deter the thief.
Take care of keys – modern key security which enables the car to 'recognise' its key, makes keyless theft hard for thieves, so they may try and steal this. Don't leave yours lying about and ensure your property is secure as a thief may try and break in to get at your car key.
Much of the above is common sense and a matter of taking care and not taking any chances. Falling car theft figures and improved security tech has made some a little complacent; it still pays to be vigilant.


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Please contact us to arrange an appointment or to obtain a quotation.
You will often require the services of a Notary Public when you have documents which are needed to be used abroad. The Notary's signature and seal will verify to the authorities in that country that any relevant checks have been carried out and that the document has been properly signed.
The presence of the Notary's signature, often in combination with her unique official seal, will render the document in question, or the facts or circumstances attested by him therein as acceptable proof for the purposes of the judicial or other public authorities in the foreign country in which they are to be used.
Who is signing or presenting the documents – are they personal papers or for a Company?
Further authentication, in the form of an "Apostille" from the UK Foreign and Commonwealth Office, and/or from the appropriate foreign consulate or embassy in England (called "Legalisation") will often be required. Where it is, this process will involve delays and additional costs about which you will be properly informed.


text:
<?php

namespace Symfony\Component\Templating\Tests\Helper;

use Symfony\Component\Templating\Helper\CoreAssetsHelper;

/**
 * @group legacy
 */
class LegacyCoreAssetsHelperTest extends \PHPUnit_Framework_TestCase
{
    protected $package;

    protected function setUp()
    {
        $this->package = $this->getMock('Symfony\Component\Templating\Asset\PackageInterface');
    }

    protected function tearDown()
    {
        $this->package = null;
    }

    public function testAddGetPackage()
    {
        $helper = new CoreAssetsHelper($this->package);

        $helper->addPackage('foo', $this->package);

        $this->assertSame($this->package, $helper->getPackage('foo'));
    }

    public function testGetNonexistingPackage()
    {
        $helper = new CoreAssetsHelper($this->package);

        $this->setExpectedException('\InvalidArgumentException');

        $helper->getPackage('foo');
    }

    public function testGetHelperName()
    {
        $helper = new CoreAssetsHelper($this->package);

        $this->assertEquals('assets', $helper->getName());
    }
}

redpajama_set_name: RedPajamaGithub


Recently when Karan Johar was asked whether he would be comfortable directing a movie with Kangana Ranaut, he was quick to reply that Kangana was 'one of the best actresses we have' in the industry. Kangana has been courting controversy on several fronts with her comments and opinions on a number of occasions. She made comments about Abhishek Bachchan, Ranbir Kapoor and Alia Bhatt, Karan Johar and about 'nepotism' ruling roost in Bollywood. Bold in her comments she is outspoken and manages to ruffle feathers along the way.
It looks like Karan Johar has decided to let the past go and move on. He has made it clear that if the role demands it he has no qualms directing Kangana.
Karan is basking in the glory of the success of his movies Kesari and Kalank. His next movie is Takht to be released later in the year.
Kangana has been a great on screen success. After Queen she had a huge hit in Manikarnika: Queen of Jhansi. Currently she has bagged 3 movies- Mental Hai Kya, Panga and Thalaivi. The last is a biopic on the late Jayalalithaa and it is believed that Kangana is charging Rs 22 Crores for that- the highest to be paid to any actress in India to date.


What is Business Gamification? And Why Does It Matter?
Today, gamification is everywhere. From email tools to goal trackers, gamifying something makes it more engaging. Business gamification uses rewards and game mechanics, such as point scoring, leaderboards, competition with fellow employees and rules of play, to boost engagement in a business setting.
In the words of KISSmetrics, "Gamification is the concept of using game design elements in non-game applications to make them more fun and engaging."
Ideal for small to enterprise-sized companies that want to enhance engagement and performance ranging from sales quota to content creation, business gamification is a modern and innovative tactic that can be applied for virtually any industry.
Disloyal Customers: Due to the evolution of the Internet and the on-demand economy customers now have dozens of purchasing options. This level of accessibility provides heightened potential for customers to partake in business with your competitors and abandon the brands they've shopped with before.
Underperforming Employees: Employees don't optimize business processes when they fail to utilize provided technology. For businesses that find themselves with underwhelming KPIs, this is likely due to poor performance by their employees. Getting employees motivated to always reach your company's KPIs is a process that business owners should account for every single day. Many business owners supplement employee motivation with optimizing technology or trying to heighten efficiency–however this does not always replicate directly to a better performing work environment.
54 percent of customers are inactive in loyalty programs.
A whopping 69 percent of clients don't partake in any online forums or communities.
50 percent of employees don't use company-provided software.
88 percent of employees don't utilize of social software or platforms.
Instead of investing in endless tech, companies need to focus on finding ways to measure and influence the actions that matter to them. The measurement has to come in the form of engagement. Are your employees, the ones using this new technology, prepared & willing to bring on an entire new method to complete their job? Look at your business and research: Is it really the lack of technology, or the lack of motivation my team has to reach certain goals?
This is where gamification comes in.
Humans are competitive by nature. Customers and employees desire recognition, praise, incentives and attention. Thankfully, gamification helps fill all these needs, and in doing so, it makes customers more loyal and employees more engaged.
Business gamification applies to many areas of activity, ranging from online marketing to employee engagement. Commonly used as an incentive to enhance productivity and growth, business gamification can be used to improve customer retention and conversion, or even to improve the employee onboarding and training processes.
When executed correctly, business gamification can have a massive impact on the business environment, leading to more committed employees, better outcomes and a larger willingness to engage in new behaviors.
In 2015, Garter research concluded that 40% of the top 1000 organizations in the world have already implemented gamification into their businesses.
Although the concept of business gamification used to seem obscure, it's achieved mainstream popularity in the last several years. In fact, M2 Research predicted that spending in the gamification market would reach $2.8 billion by the end of 2016.
70% of business transformation efforts fail due to a lack of engagement.
Business gamification works by incentivizing certain behaviors, encouraging other behaviors and tapping into a person's inborn desire to play games. People are naturally inclined to compete and constantly better themselves–so why not implement this exact mentality within your business? While game makers have understood for years that making something fun is a great way to get people to participate, companies are more recently starting to figure our and adopt the concept within their business.
For example, a company that wants to use business gamification to enhance employee engagement might create a leaderboard, wherein employees get points for their willingness to collaborate with other team members or advisors. While there are dozens of ways to facilitate gamification, each approach relies on the concept of incentivizing new behaviors and making the "game" enjoyable.
When executed properly, gamification provides recordable data, which can help a company adjust or alter its strategy as needed. Keep in mind that, while business gamification takes the foundations of game play and applies them to business, gamification doesn't involve creating a game. Instead, it utilizes game mechanics to enhance a predetermined experience or approach.
Convoso is the leading provider of Gamification applied within the contact/call center environment. By providing gamified learning management systems, Convoso helps streamline the process of agent training and onboarding which in turn, helps eliminate high agent turnover, while boosting agent engagement and productivity. By gamifying your call centers' KPIs, agents are finally incentivized to as invested in your business as you are. Fostering healthy competition within a call center of agents looking to constantly better themselves... thus the betterment of your entire company.


text:
Daily Audio
Planet Pulse
Bases loaded, nobody out. The best home run hitter in the league, Mark McGwire, is at bat. He hits a soft fly to center that turns into a triple play. A perfect pitch by an almost perfect Virgo pitcher—the Big Unit, Randy Johnson—again.
Perfection Personified
Randy Johnson (born on September 10, 1963, in Walnut Creek, California) is a perfectionist, mentally-obsessive Virgo. Not only is his Sun placed in Virgo, but the revolutionary and unorthodox Uranus, the power-seeking Pluto and the self-worth planet Venus also squeeze into Virgo in his horoscope. Be glad you don't inhabit the Big Unit's mental unit—it's a tight fit.
But then there's that time when Virgo energy flows. It's not a state of mind; it's a state of being. And in this exquisite flawlessness, the ease of effort squeezes out like toothpaste from a fresh tube. Then the Big Unit, picture perfect, easily overwhelms a batter looking for that slight chance of getting a hit.
Virgo, with its thoughtful, fastidious and highly discriminating nature, often gets in its own way, typically by overdoing the thought process. Johnson claims he doesn't like to pitch on his birthday, which is late in the season. During the time when Virgo maximizes in the sky (when the Sun is in Virgo), the tendency to strive excessively in the direction of divine perfection can be overwhelming. The pressure causes too much mental agitation.
Perfect Perfectionism
There's a funny thing about the Venus in Virgo placement for the Big Unit. Venus can get jealous, very jealous. And when jealous, she's jealous with incalculable wrath (wrath originally meant energy). Then she turns competitive. Venus inspires other pitchers to increase their desire when they're up against Johnson. Mediocre pitchers often throw their best game of the season against him. Thinking, "I want what he's got," they rise to the occasion, perfecting their skills temporarily. Once Johnson had four shut outs tossed against him in a row. It's hard for even the Big Unit to compete with that.
An Odd Duck
Not only is Randy Johnson towering above most of his peers in height, but he is an unusual-looking man. His long hair, generally soaked with the perspiration of his toils, drips onto his uniform. His angled features gain intensity as he focuses on the target of the catcher's mitt. And his Uranus, in the pristine Virgo, allows him leeway and eccentricities not granted other players because of his uniquely crafted skill.
During the Arizona Diamondback's first year, there was a regulation on hair length and facial hair for team members. I guess now anything goes, since they bought Randy Johnson, with his long hair and occasional beard, for megabucks. Johnson's Uranus (which is a seven-year generational placement) shows a certain need to stand out in one way or another. Johnson has done it with not only his appearance, but his precise skill and extreme domination over other players.
Then There's Pluto
The planet Pluto, currently in Sagittarius, is forming a square to Johnson's Uranus that may help him to break records. At the All Star break Johnson led all the pitchers, with over 198 strikeouts and a possibility of reaching the single season strike out record held by Nolan Ryan. Given the current position of overpowering, intimidating Pluto, the odds remain good that Johnson will keep his control, strength and ability honed to exceptional proportions, which can only help him break the record. Unlike struggling teammate Omar Dahl, who has a Pluto transit as well (Pluto square the natal Sun), Randy's transiting configuration takes the challenge and thrives on the intensity of the game more than ever before.
When the Big Unit was born, Pluto—the powerful, the intimidating, the unconquerable—was in Virgo with all of his other planets, adding power to the combination. Get him on the mound and watch him strike out the side, with his fist clenched in the air, mouth flaming with energetic mutterings that most lip readers hesitate to translate, while saliva flies from his mouth. His raw Plutonian energy is formidable.
His six foot ten inch frame assists him in keeping batters off balance. When he comes crashing toward the plate, his long arm hurling the ball at what the batter must assume is his head, the natural instinct is to run to the next state. Batters duck from his pitches, and umpires call strikes. Some batters argue the ball was so fast the umpire didn't know where it was anyway. Doesn't matter—they're still out.
But It's Because He's Good
It's all because Randy's good. He's good because he studies the game. He's good because he perfects his craft. He's good because he focuses his intensity and drive for perfection into a healthy, unbeatable combination. We should all take copious Virgo notes.
Philip Sedgwick began his study of astrology in 1969. He is the author of Astrology of Deep Space, Astrology of Transcendence, The Sun at the Center: A Primer of Heliocentric Astrology, The Galactic Ephemeris (a compilation of over 8,300 points in deep space).
For more information about Philip Sedgwick, click here.
Other StarIQ articles by Philip Sedgwick:
Joyce Jensen 11/21/2002
Quaoar 10/11/2002
Carly Fiorina: Hewlett Packard's Head Profit 11/22/2000
The Boy Scouts: On Our Honor 11/8/2000
Hugh Hefner Kisses and Tells 11/3/2000
Rumble Under New York 10/24/2000
Bias in the Bureau of Indian Affairs 10/10/2000
The Wild, Wild Cards 10/5/2000
Ralph Nader: Green for the Red, White and Blue 9/14/2000
The FAA: Stormy Skies 9/6/2000
Whew, That Was Close! 9/1/2000
The West is Burning 8/27/2000
Air Rage 8/23/2000
Martin Luther: Ecumenical Evolution 8/13/2000
David Wells: Tapping the Wells 8/8/2000
Are You Ready for Some Football, Dennis Miller? 8/1/2000
Andres Galarraga: The Big Cat is Back 7/25/2000
Solar Flares 7/17/2000
All Stars Rising 7/11/2000
Staying Strong 7/4/2000
Investing in Bonds (Long Term) 6/27/2000
Sara the Tiger Trainer 6/24/2000
Nipped by the Bud 6/20/2000
Fathers and Sons 6/13/2000
Junior 6/6/2000
The Bronx Enigma: Derek Jeter 5/30/2000
Big Mac 5/23/2000
Bypass for the Express 5/16/2000
Ila Borders 5/9/2000
Swinging Sammy Sosa! 5/2/2000
Ripken Can Still Rip 4/25/2000
Neon Deion Flickers 4/11/2000
Baseball Gets Oriented 4/4/2000
A Rose is a Rose 3/28/2000
Tony Gwynn: Steady at the Plate 3/21/2000
Buz Myers 3/16/2000
Strawberry's in a Jam 3/14/2000
Off His John Rocker 2/29/2000