text:
In this section: New Drugs at FDA: CDER's New Molecular Entities and New Therapeutic Biological Products
New Drugs at FDA: CDER's New Molecular Entities and New Therapeutic Biological Products
Novel Drug Approvals for 2020
Development & Approval Process | Drugs
Novel Drugs Summary 2016
Novel Drugs Summary
Center for Drug Evaluation and Research
www.fda.gov/drugs
Print version (PDF - 4MB)
Welcome to the FDA's Center for Drug Evaluation and Research's (CDER's) sixth annual Novel Drugs Summary.
Each year, CDER approves hundreds of new medications, most of which are variations of previously existing products, such as important new dosage forms of already-approved products, or cost-saving generic formulations. These new products contribute to quality of care, greater access to medication, more consumer choice, and a competitive marketplace that enhances affordability and public health. However, a small subset of these new approvals, referred to as novel drugs, are among the more innovative products that often help advance clinical care to another level. At the end of each calendar year, CDER summarizes these new products.
Our annual summary reports the number of novel drugs approved. However, we also focus on the medical value of many of these new drugs, their contributions to enhanced patient care, and the various regulatory tools CDER used to help ensure their safe and efficient development and approval. In 2016, novel approvals include the first treatment for patients with spinal muscular atrophy, the first drug approved to treat Duchenne muscular dystrophy, a new drug to treat hallucinations and delusions in some people with Parkinson's disease, a new drug to treat patients with a rare chronic liver disease known as primary biliary cirrhosis, and two new treatments for patients with hepatitis C. The field also includes new treatments for patients with ovarian cancer, bladder cancer, soft tissue sarcoma, and chronic lymphocytic leukemia—as well as two new diagnostic agents for detecting certain forms of cancer.
All of these newly approved products were required to meet our rigorous premarket safety standards—and they will all be part of a strong postmarket safety surveillance system watching how they perform after they are more widely used by larger patient populations. Complementing this year's summary of novel approvals is CDER's recent report titled, Drug Safety Priorities 2015-2016, which details the Center's key safety priorities as well as the depth and versatility of drug safety initiatives across CDER and the FDA. The report includes program updates and milestones achieved since the start of 2015, describing a variety of the FDA's most important efforts in drug safety science, surveillance, and oversight.
We hope our Novel Drugs summary provides an appreciation of the expected impact that many of the novel drug approvals of 2016 will have on patient care, as well as the valuable role CDER played in helping to bring these drugs to market.
Janet Woodcock, M.D.
Director, Center for Drug Evaluation and Research
CDER's 2016 Novel Drug Approvals
22 novel drugs
In calendar year 2016, FDA's Center for Drug Evaluation and Research (CDER) approved 22 novel drugs, approved either as new molecular entities (NMEs) under New Drug Applications (NDAs) or as new therapeutic biologics under Biologics License Applications (BLAs). Listed below are CDER's novel drugs of 2016.*
Novel drugs are often innovative products that serve previously unmet medical needs or otherwise significantly help to advance patient care and public health. NMEs have chemical structures that have never been approved before. However, in some cases an NME may have actions similar to earlier drugs and may not necessarily offer unique clinical advantages over existing therapies. This report summarizes all of the 2016 NME and novel BLA approvals, emphasizing those that offer new and innovative treatments to patients in need.
The vertical bars in the graph below indicate the number of novel drugs approved by CDER in each year of the past decade. CDER approved 22 novel drugs in 2016. From 2007 through 2015, CDER has averaged about 30 novel drug approvals per year.
Applications for new approvals remain steady
CDER approved a lower than average number of novel drugs in 2016, but the number of applications for these drugs that sponsors have submitted over time has remained relatively stable.
The points connected by lines in the graph below indicate the number of new NDA and BLA applications for NMEs and new therapeutic biologics CDER has received and filed for approval during the last 10 years. From 2007 through 2015, CDER filed an average of about 36 applications for novel drugs per year. CDER estimates 41 filings for 2016, which is consistent with previous years in this decade.
Novel Drugs Approved by CDER in Calendar Year 2016 (see New Molecular Entity and Therapeutic Biologics of 2016 for their non-proprietary names, approval dates, and what they are used for.)
Adlyxin, Anthim, Axumin, Briviact, Cinqair, Defitelio, Epclusa, Eucrisa, Exondys 51, Lartruvo, Netspot, Nuplazid, Ocaliva, Rubraca, Spinraza, Taltz, Tecentriq, Venclexta, Xiidra, Zepatier, Zinbryta, Zinplava.
* This information is accurate as of December 31, 2016. In rare instances, it may be necessary for FDA to change a drug's NME designation or the status of its application as a novel BLA. For instance, new information may become available which could lead to a reconsideration of the original designation or status. If changes must be made to a drug's designation or the status of an application as a novel BLA, the Agency intends to communicate the nature of, and the reason for, any revisions as appropriate.
In 2016 CDER approved 22 novel drugs
22 novel drug approvals in CY 2016 is less than the average number approved annually during the past decade
From 2007 through 2015 CDER averaged about 30 novel drug approvals per year
*The 2016 filed numbers include those filed in CY 2016 plus those currently pending filing (i.e., within their 60 day filing period) in CY 2016.
Receipts that received a "Refuse to File" (RTF) or "Withdrawn before filing" (WF) identifier are excluded.
Multiple submissions (multiple or split originals) pertaining to a single new molecular/biologic entity are only counted once.
The filed number is not indicative of workload in the PDUFA V Program.
Impact on Public Health
Many of the 22 novel drugs CDER approved in 2016 are notable for their potential positive impact and unique contributions to quality medical care and public health.
First-in-Class
CDER identified eight of the 22 novel drugs approved in 2016 (36%) as First-in-Class, which is one indicator of the innovative nature of a drug. These drugs often have mechanisms of action different from those of existing therapies.
Defitelio, Exondys 51, Ocaliva, Spinraza, Venclexta, Xiidra, Zinbryta, Zinplava
Noteworthy First-in-Class products include:
Defitelio - To treat adults and children who develop hepatic veno-occlusive disease with additional kidney or lung abnormalities after they receive a stem cell transplant from blood or bone marrow called hematopoietic stem cell transplantation
Zinbryta - To treat multiple sclerosis
Drugs for Rare Diseases
Nine of the 22 novel drugs approved in 2016 (41%) were approved to treat rare or "orphan" diseases that affect 200,000 or fewer Americans. This is significant because patients with rare diseases often have few or no drugs available to treat their conditions.
Anthim, Defitelio, Exondys 51, Lartruvo, Netspot, Ocaliva, Rubraca, Spinraza, Venclexta
Noteworthy examples of drugs to treat rare diseases among the 2016 novel drugs include:
Exondys 51 - To treat patients with Duchenne muscular dystrophy
Spinraza - For treatment of patients with spinal muscular atrophy
Other Noteworthy Novel Drugs of 2016
In addition to the noteworthy examples of innovative First-in-Class and "orphan" new products mentioned above, the 2016 novel drug field also includes a variety of other notable drugs. These include cancer therapies, Lartruvo to treat patients with a form of cancer called soft tissue sarcoma; Rubraca, to treat women with ovarian cancer; Tecentriq, to treat patients with the most common type of bladder cancer (urothelial carcinoma), and Venclexta, for certain patients with chronic lymphocytic leukemia. Also notable are two diagnostic agents, Axumin, which is an imaging agent to help detect prostate cancer, and Netspot, another imaging agent used to detect rare neuroendocrine tumors.
This year's novel approvals also include two new treatments for hepatitis C—Epclusa, to treat all six major forms of hepatitis C virus; and Zepatier, to treat adult patients infected with chronic hepatitis C virus genotypes 1 and 4.
Additional noteworthy approvals include Nuplazid, to treat hallucinations and delusions associated with psychosis experienced by some people with Parkinson's disease, and Ocaliva, to treat patients with a rare chronic liver disease known as primary biliary cirrhosis.
Methods for expediting innovative novel drugs to market
CDER used a number of regulatory methods to expedite the development and approval of novel drugs in 2016, including: Fast Track, Breakthrough, Priority Review, and Accelerated Approval.
Fast Track drugs have the potential to address unmet medical needs. Eight of the 2016 novel drugs (36%) were designated by CDER as Fast Track. Fast Track speeds new drug development and review, for instance, by increasing the level of communication FDA allocates to drug developers and by enabling CDER to review portions of a drug application ahead of the submission of the complete application.
Drugs designated with Fast Track status were: Anthim, Defitelio, Epclusa, Exondys 51, Lartruvo, Ocaliva, Spinraza, Zinplava
Breakthrough therapies are drugs with preliminary clinical evidence demonstrating that the drug may result in substantial improvement on at least one clinically significant endpoint (e.g., study result) over other available therapies. CDER designated seven of the 2016 novel drugs (32%) as Breakthrough therapies. A breakthrough therapy designation includes all of the Fast Track program features, as well as more intensive FDA guidance on an efficient drug development program. Breakthrough status is designed to help shorten the development time of a potential new therapy.
Drugs designated with Breakthrough status were: Epclusa, Lartruvo, Nuplazid, Rubraca, Tecentriq, Venclexta, Zepatier
Priority Review
A drug receives a Priority Review if CDER determines that the drug could potentially provide a significant advance in medical care. The drug is reviewed within six months instead of the standard 10 months. Fifteen of the 2016 novel drugs (68%) were designated Priority Review.
Drugs designated with Priority Review status were: Axumin, Defitelio, Epclusa, Exondys 51, Lartruvo, Netspot, Nuplazid, Ocaliva, Rubraca, Spinraza, Tecentriq, Venclexta, Xiidra, Zepatier, Zinplava
Accelerated Approval
The Accelerated Approval program allows for early approval of a drug for serious or life threatening illness that offers a benefit over current treatments. CDER approved six of the 2016 novel drugs (27%) under the Accelerated Approval program. This approval is based on a "surrogate endpoint" (e.g., a laboratory measure) or other clinical measure that we consider reasonably likely to predict a clinical benefit of the drug. Once Accelerated Approval is granted, the drug must undergo additional testing to confirm that benefit. This speeds the availability of the drug to patients who need it.
Drugs that received Accelerated Approval were: Exondys 51, Lartruvo, Ocaliva, Rubraca, Tecentriq, Venclexta
Overall use of expedited development and review methods
Sixteen of the 2016 novel drugs (73%) were designated in one or more expedited categories of Fast Track, Breakthrough, Priority Review, and/or Accelerated Approval. Each of these designations helps expedite the speed of the development and/or approval process and is designed to help bring important medications to the market as quickly as possible.
Drugs that used at least one expedited review program include: Anthim, Axumin, Defitelio, Epclusa, Exondys 51, Lartruvo, Netspot, Nuplazid, Ocaliva, Rubraca, Spinraza, Tecentriq, Venclexta, Xiidra, Zepatier, Zinplava
Fast Track 36%
Breakthrough 32%
Priority Review 68%
Accelerated Approval 27%
One or more expedited development and review methods 73%
PDUFA Goal Dates Met
Under the Prescription Drug User Fee Act (PDUFA), sponsors are assessed user fees that provide FDA with the additional resources needed to meet performance goals. Throughout the year, CDER was able to meet or exceed most PDUFA goal dates for application review, agreed to with the pharmaceutical industry and approved by Congress. In 2016, CDER met its PDUFA goal dates for 95% of the novel drugs approved (21 of 22).
Drugs for which CDER met our PDUFA review goal include: Adlyxin, Anthim, Axumin, Briviact, Cinqair, Defitelio, Epclusa, Eucrisa, Lartruvo, Netspot, Nuplazid, Ocaliva, Rubraca, Spinraza, Taltz, Tecentriq, Venclexta, Xiidra, Zepatier, Zinbryta, Zinplava
In 2016, CDER met its PDUFA goal for 95% of the novel drugs approved in 2016
First Cycle Approval
CDER approved 21 of the novel drugs of 2016 (95%) on the "first cycle" of review, meaning without requests for additional information that would delay approval and lead to another cycle of review.
Drugs approved on the first cycle include: Adlyxin, Anthim, Axumin, Briviact, Cinqair, Defitelio, Epclusa, Eucrisa, Exondys 51, Lartruvo, Netspot, Nuplazid, Ocaliva, Rubraca, Spinraza, Taltz, Tecentriq, Venclexta, Zepatier, Zinbryta, Zinplava
Approval in the United States Before Other Countries
Comparing approval to other countries offers another measure of approval efficiency. Although regulatory processes differ widely between FDA and those of regulatory agencies in other countries, 19 of the 22 novel drugs approved in 2016 (86%) were approved in the United States before receiving approval in any other country.
Drugs approved first in the U.S. include: Anthim, Axumin, Cinqair, Epclusa, Eucrisa, Exondys 51, Lartruvo, Netspot, Nuplazid, Ocaliva, Rubraca, Spinraza, Taltz, Tecentriq, Venclexta, Xiidra, Zepatier, Zinbryta, Zinplava
First Cycle Approval 95%
Approved First in U.S. 86%
This document represents a broad overview of CDER approvals of novel drugs for calendar year 2016.
A continuing upward trend for the annual number of CDER's novel drug approvals relies on a corresponding increase in the number of drug applications submitted for approval. During the past decade, submissions of applications for NMEs and novel BLAs by the pharmaceutical and biotechnology industry have remained relatively stable.
More important than the quantity of novel drugs approved in 2016 are the qualities of the new drugs the pharmaceutical industry has developed and the important new roles these drugs are serving to advance medical care.
Also noteworthy is the efficiency with which most of these drugs were reviewed and approved. CDER used a variety of expedited development and review regulatory tools in an effort to help speed these drugs to market.
In all cases, while striving for efficiency of review and approval of applications for new drugs, CDER maintains its rigorous standards for demonstration of effectiveness and safety in the process.
More important than the quantity of novel drugs approved by CDER in 2016 is their medical value and the important new roles they are serving to advance patient care.


With the prospect of energy prices rising means many firms and organisations will be looking to find a cheap business energy supplier in a bid to mitigate rising costs.
This makes sense since having cheaper energy means profitability will be boosted but few firms take the trouble to find a cheaper energy supplier.
Even though the process of finding a new supplier for business energy is much simpler, many firms tend to remain with their current supplier on a rollover contract basis.
One startling statistic revealed by the Competition and Markets Authority in 2015 revealed that 40% of UK businesses have not bothered to switch their energy supplier in the last five years which means many could be overpaying by huge amounts.
It's important to appreciate that for any organisation looking for cheap business electricity deals that they are straightforward and quick to find.
While many firms may undertake an Internet search to find a new supplier, it is much easier and quicker to use an organisation that looks at the entire market to find the best deal and tariff for the business.
It's also important to appreciate that business energy suppliers do not have a one size fits all approach to their energy prices, unlike domestic suppliers, so they will be needing more information so they can tailor a suitable tariff.
In addition to finding cheap business energy suppliers, many firms will be looking to find cheap business gas suppliers for their heating needs, for instance.
That's because energy firms will supply electricity and gas separately and may offer a dual billing arrangement; they can even supply different tariffs for different premises. Some suppliers will also offer green energy deals for those who want to do their bit for the environment.
While many firms could undertake the process themselves and ring around several potential business energy suppliers to find the best deal, which may take some haggling and negotiation, they will inevitably save money.
The amount to be saved will vary depending on the business's size but the potential can be huge; some firms will save thousands of pounds every year by simply switching energy suppliers.
So, for those businesses looking to find cheap business energy suppliers then contact the experts at D-energi who can offer impartial advice and find a cheaper deal for the business to save money on their bills.


text:
package VMOMI::UserSearchResult;
use parent 'VMOMI::DynamicData';

use strict;
use warnings;

our @class_ancestors = (
    'DynamicData',
);

our @class_members = (
    ['principal', undef, 0, ],
    ['fullName', undef, 0, 1],
    ['group', 'boolean', 0, ],
);

sub get_class_ancestors {
    return @class_ancestors;
}

sub get_class_members {
    my $class = shift;
    my @super_members = $class->SUPER::get_class_members();
    return (@super_members, @class_members);
}

1;

redpajama_set_name: RedPajamaGithub


text:
Q: Reycle Bitmaps in Android I am using google map view and adding markers to it using this code:
googleMap.addMarker(new MarkerOptions()
.position(chargingStationObject.geoData)
.title(chargingStationObject.name)
.snippet(chargingStationObject.stationAvailability)
.data((chargingStationObject.id))
.icon(iconDescriptor));

iconDescriptor is created like this:
iconDescriptor = BitmapDescriptorFactory.fromResource(getResources()
     .getIdentifier("mapicon", "drawable", getActivity().getPackageName()));

When there are too many markers on my map, the heap is filled to its maximum, and after a while the app crashed with an out-of-memory-exception. This only happens when there are or have been a larger amount of markers on the map. Even after I call .clear(), the heap is still rather large.
Maybe the bitmaps haven't been recycled properly?

A: Do on thing.
I assume, you are using same marker for all location.
Put the condition here
if(iconDescriptor==null){
            iconDescriptor = BitmapDescriptorFactory.fromResource(getResources().getIdentifier("mapicon", "drawable", getActivity().getPackageName()));
        }

Do not create new bitmap for every marker use just one copy for that and see what happens.

A: for handle larger amount of markers on google map have to use Google Maps Android Marker Clustering Utility
For find more visit,
https://developers.google.com/maps/documentation/android/utility/marker-clustering

redpajama_set_name: RedPajamaStackExchange


Are you looking for an interesting, versatile workout? The ProForm Acitvator is designed to give you the ability to lose weight quicker than ever before. The product combines the support of a stabilizing handle with dumbbells to help achieve the most from your next workout. There is a console with a thirty, forty five, and sixty second timer and you can select the vibration intensity as well. The product has easy to use foot controls and a slip-resistance platform. One pair of thirty pound selectable weight dumbbells is included.


The Met Office has just announced that last month was the wettest June on record back to 1910, while July has started with more heavy rain. Is this just another example of the variability of English weather, or is it part of a longer term trend?
The Met Office graph in Figure 1 shows a clear cut change to drier summers around 1960, followed by a return to earlier levels in the last decade or so. The Met Office also keep records going back to 1766 for England & Wales, (but not Scotland), and these give quite a bit of extra information.
1) As seen in Figure 1, the long term trend has been towards drier summers since 1766.
2) Since 1970, though, the trend has been towards wetter summers.
3) As figure 4 shows, most of the wettest summers occurred in the earlier part of the record. Only one of the top twenty wettest summers has occurred since 1956, which was in 2007. The three wettest years were 1912, 1879 and 1829.
Earlier this year DEFRA, the UK's Department for Environment, issued its "Climate Change Risk Assessment", which projected a "change in average summer rainfall volumes ranging from a decrease of about 60% to an increase of about 10%" by the 2080's. (It also forecast an increase in winter rainfall, which has been declining in recent years).
Perhaps they should take another look at their models.
MORAL – Be extremely of any claims about "normal" climate (especially when issued by the Met Office, or any other organisations run by ex WWF executives).
Your final sentence is so true. Manipulation of statistics seems to be the Met office's favourite pastime.
So the back story is more Greenie infiltration and subversion.


text:
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John Michael McDonagh's problematic follow-up to The Guard begins with an ingenious, arrest(...)
Father and son go head -to-head in IFTAs
John Butler's comedy The Stag and John Michael McDonagh's state-of-the-nation piece Calvary have topped the charts in the nominations for the upcom(...)

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: How to build a CSS dial guage dynamically?
*

*How can I add the grey dial underneath like in the picture below?

*I have created a dial that shows 100%. I was wondering if I can write a function to dynamically render the %(may be by using a math.random function)?

.ring {
  position: relative;
  width: 50vmin;
  height: 50vmin;
  background-image: radial-gradient(#C816CDFF 0, #C816CDFF 50%, transparent 50%, transparent 100%),
  radial-gradient(#C816CDFF 0, #C816CDFF 50%, transparent 50%, transparent 100%),
  radial-gradient(white 0, white 66%, transparent 66%),
  conic-gradient(#C816CDFF 0, #c816cd 150deg, white 60deg, white 200deg, #C816CDFF 210deg, #C816CDFF 360deg);
  background-size: 5.0% 5.0%, 5.0% 5.0%, 100% 100%, 100% 100%;
  background-repeat: no-repeat;
  background-position: 27.2% 95.6%, 75.5% 94.2%, center center, center center;
  border-radius: 50%;
  border-style: none;
}

.speed {
  display: inline-block;
  position: absolute;
  top: 50%;
  left: 50%;
  transform: translateX(-50%) translateY(-50%);
  text-align: center;
  color: gray;
}

.speed .number {
  font-size: 10px;
  font-weight: bold;
  color: black;
}

.speed .units {
  font-size: 25px;
  color: black;
}

Lorem ipsum dolor

100%


Bullish scenario: Long positions above the daily pivot point 1.0990$ with targets at 1.1070$ next 1.1130$ in extension.
Alternatively, Short positions below the daily pivot point 1.0990$ with targets at 1.0930$ next 1.0855 in extension.
Bullish scenario: Long positions above the daily pivot point 1.5495$ with targets at 1.5575$ next 1.5690$ in extension.
Alternatively, Bearish Scenario: Short positions below the daily pivot point 1.5495$ with targets at 1.5380$ next 1.5295$ in extension.
Bullish scenario: Long positions above the daily pivot point 0.9470 with targets at 0.9510 next 0.9560 in extension.
Alternatively, Bearish scenario: Short positions below the daily pivot point 0.9470 with targets at 0.9420 next 0.9380 in extension.
Bullish scenario: Long positions above the daily pivot point 122.45 with targets at 122.95 next 123.35 in extension.
Alternatively, Bearish scenario: Short positions below the daily pivot point 122.45 with targets at 122.05 next 121.60 in extension.
Bullish scenario: Long positions above the daily pivot point 1.2715 with targets at 1.2785 next 1.2850 in extension.
Alternatively, Bearish scenario: Short positions below the daily pivot point 1.2715 with targets at 1.2655 next 1.2585 in extension.
Bullish scenario: Long positions above the daily pivot point 0.7450 with targets at 0.7505 next 0.7550 in extension.
Alternatively, Bearish scenario: Short positions below the daily pivot point 0.7450 with targets at 0.7400 next 0.7350 in extension.
Bullish scenario: Long positions above the daily pivot point 0.6655 with targets at 0.6690 next 0.6720 extension.
Alternatively, Bearish scenario: Short positions below the daily pivot point 0.6655 with targets at 0.6625 next 0.6590 in extension.
Pivot points are very useful tools for FX professional traders that use the previous bars' highs, lows and closings to project potential support and resistance levels for future bars.


text:
Home»Premier League»10 key things to know ahead of Fulham vs. Liverpool Premier League opener – Liverpool FC
10 key things to know ahead of Fulham vs. Liverpool Premier League opener – Liverpool FC
By admin August 5, 2022 No Comments6 Mins Read
Liverpool's 2022/23 Premier League campaign gets underway with a trip to face newly-promoted Fulham on Saturday.
Fulham vs. Liverpool
Premier League (1) | Craven Cottage
Saturday, August 6, 2022 | 12.30pm (BST)
It's back! After a five-week pre-season, Liverpool return to Premier League action this Saturday lunchtime.
The Reds kickstarted their campaign with an impressive Community Shield victory against Man City last weekend, and will be hoping for a similar result at Craven Cottage.
Here's everything you need to know before Liverpool's first league clash of the season.
1. Here we go again!
That summer absolutely flew by, didn't it?
12 weeks after Liverpool's 2021/22 Premier League finale against Wolves, it's time to start things all over again.
The final match of the previous campaign was, of course, a disappointing one, with the Reds falling short to Real Madrid in the Champions League final.
But spirits were instantly lifted after another mind blowing parade through the city centre the following day.
There have been changes to the squad over the course of the summer, with the likes of Sadio Mane, Divock Origi and Takumi Minamino departing and Fabio Carvalho, Darwin Nunez and Calvin Ramsay joining the club.
Pre-season trips to Asia and Austria all went to plan and last weekend's Community Shield victory proved the Reds are more than ready for the campaign ahead. We go again!
2. Is Alisson fit?
Thankfully, yes!
Having missed a large chunk of pre-season, Klopp has confirmed Alisson is now "fine" after recovering from an abdominal injury.
The Brazilian sustained the problem during Liverpool's tour of Asia last month, and with Caoimhin Kelleher also sidelined, Adrian ended up playing more minutes than any other Liverpool player during pre-season.
Good to have you back, Ali!
3. 8, possibly 9 players unavailable
Klopp provided an extensive injury update during Friday's pre-match press conference, with a number of Liverpool players still unavailable for selection.
Kelleher, Calvin Ramsay, Kaide Gordon and Diogo Jota remain out, having missed all of the summer friendlies through injury.
Ibrahima Konate, Kostas Tsimikas, Curtis Jones and Alex Oxlade-Chamberlain are also sidelined after picking up knocks during pre-season.
Naby Keita missed last Sunday's friendly against Strasbourg through illness but could yet be available for the trip to Craven Cottage, with Klopp expecting the Guinean to train on Friday.
The Liverpool boss also added that left-back Tsimikas could be back in training next week.
4. Predicted Reds lineup – Firmino or Nunez?
NEW: 2 Liverpool lineups vs. Fulham with Firmino or Nunez decision https://t.co/XvYkA8bsYy
— This Is Anfield (@thisisanfield) August 5, 2022
Expect Alisson to go straight back into the team, with Adrian dropping to the bench. Konate's injury should mean that Joel Matip continues alongside Virgil van Dijk in the heart of the Liverpool defence.
The big call for Klopp is in attack, with Roberto Firmino and Darwin Nunez battling it out for a place up front.
Don't be surprised if the Brazilian gets the nod again, with Klopp reiterating on Friday that he's in no rush to throw Nunez straight in at the deep end.
The reintroduction of the five substitutions rule means Klopp will be able to call upon more players to impact the game in the second half, with the likes of Nunez, Elliott, Keita and Fabio Carvalho all impressing off the bench against City.
Possible Liverpool XI: Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Fabinho, Henderson, Thiago; Salah, Diaz, Firmino
5. What to expect from Fulham?
Earlier this week, Fulham manager Marco Silva went as far as to say that his side were "not ready" for their Premier League opener against the Reds. Sounds good to us!
"I have to tell you, and I don't want to speak for too much time about the situation, I want to be clear with you; now we have 16 senior players in our squad," he told reporters.
"No one competes at this level with 16 senior players in your squad."
The Cottagers were promoted to the Premier League as Championship winners last season but Liverpool have, of course, taken one of their star performers off them in Fabio Carvalho.
Centre-back Shane Duffy arrived on loan from Brighton on Friday and could feature against the Reds, with Joao Palhinha, Andreas Pereira, Kevin Mbabu, Bernd Leno and Manor Solomon their other summer signings.
Ex-Liverpool winger Harry Wilson has been ruled out of the match through injury, while midfielder Nathaniel Chalobah is also absent.
6. "Massive talent"
In his pre-match press conference, Klopp was asked how Carvalho, who arrived from Fulham earlier this summer, has settled into life on Merseyside.
"Top player. I love it. Massive talent.
"Really good kid and really happy to have him, so very important for us because we count on this age group as well.
"We don't wait now until they are 22, 23 or whatever and use them. No, no, no. He is ready like Harvey is ready in the similar age group. That's really cool.
"We all need luck in life as well with injury and stuff like this, but without that he will be a really important player for us."
A goal on his league debut against his former team? Don't rule it out!
7. The man in the middle
The Reds' first Premier League referee of the season will be Andy Madley, who has only taken charge of five Liverpool matches before this one.
The good news is that they were all Liverpool wins!
Madley refereed 16 Premier League matches last season, including the 3-0 victory over Crystal Palace at Anfield last September.
8. Did you know?
Liverpool failed to win either of their league encounters against Fulham in 2020/21.
The first saw the Reds held to a 1-1 draw at Craven Cottage in December 2020, on a day Joel Matip started as the team's only recognised centre-back alongside Fabinho, before being forced off with an injury of his own at half-time. Bad, bad memories.
The return fixture saw Fulham win at Anfield, with Mario Lemina's strike enough to secure them the three points. Liverpool's back four that day was Neco Williams, Nat Phillips, Rhys Williams and Andy Robertson. Even worse memories!
9. Not the only Liverpool game this weekend…
Think the friendlies are all over? Think again!
Those who don't start at Craven Cottage are likely to be involved in a behind closed doors match that's been scheduled for Sunday, which is believed to be against Aston Villa.
The Reds took on the same opposition in a similar friendly this time last year, one day after their opening day victory against Norwich.
Players who weren't involved at Carrow Road featured against Villa the next day, and that will be the case again this time around, as Klopp looks to give his whole squad more valuable minutes.
10. Follow TIA's live blog!
Liverpool's first league game of the season is available to watch live on BT Sport for viewers in the UK.
If you are unable to watch the action, Henry Jackson will be guiding you through proceedings on This Is Anfield's matchday live blog.
It's good to be back. Up the Reds!
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A local guide to Wesley Chapel NC real estate, news, events, neighborhoods, schools and more. Search Wesley Chapel NC homes and land for sale.
For local and knowledgeable service in Wesley Chapel NC real estate, contact Carol Fox of Allen Tate Realtors directly at 704-905-3935.
Although the Village of Wesley Chapel was not incorporated until 1998, Wesley Chapel as a community has existed since the early 1800s. The center of the Wesley Chapel community was the intersection of Potters Road and Highway 84. Here the Wesley Chapel Methodist Church started in a brush arbor about 1832 with a church building built shortly thereafter. The various church buildings in Wesley Chapel held school classes from the beginning. What is believed to be the first rural public high school in North Carolina was established at Wesley Chapel in 1904. A new brick school building was built at Wesley Chapel in 1922. Today,Wesley Chapel Elementary School at the Potters Road/Highway 84 intersection continues the educational tradition of the village.
Wesley Chapel incorporated in 1998 with approximately 2500 acres. It has grown to over 5300 acres through involuntary annexations since then. The current town center is at the intersection of Highway 84 and Waxhaw-Indian Trail Road. The Wesley Chapel Village Commons includes a Target, Petsmart, several restaurants, two grocery stores, other shops and a YMCA. The Village of Wesley Chapel will construct a town hall at this site as well.
A community visioning and planning process is underway in the village. Results of a September 2007 community survey provides a glimpse of the lifestyles of Wesley Chapel residents. Seventy one percent are newcomers, having lived in Wesley Chapel for nine years or less. Twenty five percent of survey respondents work at home while 36 percent commute 50 or more miles per day. Approximately 23 percent of the commuters drive to Uptown Charlotte while another 35% drive to South Charlotte.
When asked for lifestyle preferences, most survey respondents prefer preserving the rural small town atmosphere and agricultural activity of the area. Most prefer single family homes on large lots. Eighty seven percent favor open green space and recreation areas.
Most Wesley Chapel neighborhoods are relatively new. They tend to be in the moderate price range on third acre to half acre lots. Many of the newer neighborhoods include neighborhood amenities such as pools, playgrounds and walking trails.
Search for homes in Wesley Chapel NC by clicking the links below. Search results may include properties outside the Village of Wesley Chapel.
Ask me a question about Wesley Chapel NC.
I'll be happy to answer your questions about neighborhoods, homes for sale and living in Wesley Chapel NC. Drop me a note via the email form below or give me a call at 704-905-3935.


text:
Окръг Кюстенджа или Окръг Констанца (Județul Constanța) e разположен в най-югоизточната част на Румъния. На север граничи с окръг Тулча, на юг – с румънско-българската граница, на запад – река Дунав го разделя от окръзите Кълъраш, Яломица и Браила, а на изток – с Черно море.

С площ от 7071,29 кв. км, Окръг Кюстенджа обхваща 2,97% от площта на Румъния, с което заема 7-о място сред окръзите по площ и 5-о по население. Населението му е 671 910 души (по приблизителна оценка от януари 2020 г.).

Списък на населените места в окръг Кюстенджа

Общински градове
 Кюстенджа
 Меджидия
 Мангалия

Градове

Кметства

Морски курорти

Транспорт
Окръгът има добре развита пътна и железопътна мрежа, речни пристанища (Черна вода, Хърсово, Меджидия, Басараби, Овидиу и Аджиджа), морски пристанища (Кюстенджа, Аджиджа, Мангалия и Мидия), международно летище ("Михаил Когълничану" в Констанца) и местно летище (край Тузла).

Източници

redpajama_set_name: RedPajamaWikipedia


text:
From Beads to the Big House: Scenes From a Mardi Gras Ride-Along
The GQ Box
The GQ Shop
You know about the revelry every year in New Orleans—booze, boobs, and bad behavior reign on Fat Tuesday. But what about on the other side? One GQ reporter hits NOLA and hangs with an overworked police department, scanning the streets, watching the mayhem, and taking a closer look at what goes down inside a jail during America's biggest party
By Rafi Kohan
Lieutenant Joe Valiente picks me up just after 7a.m. on Mardi Gras morning. His is the fourth squad car I've been in since my plane touched down, barely 15 hours earlier, at Louis Armstrong airport. I put on my seatbelt, and we shoot down St. Charles Avenue. The radio is quiet, the day's parades still hours off, and yet the street's median, the eventual viewing gallery, is already peopled with bleary-eyed revelers. Some of them have been here all night, camping out for a spot.
I wanted to spend the day in jail. That was the original idea. Instead, I'm riding shotgun with the cops, with the New Orleans Police Department, perhaps the only people in or around Big Easy who could do without Mardi Gras. Take it or leave it. Actually, leave it. They're like the Grinches of Carnival—not because they hate fun and breasts; they're just so damn overworked, deep-fried oyster shells, husks.
Standing over six feet tall, with a neatly trimmed salt-and-pepper mustache (OK, mostly salt) and a full helmet of hair to match, Valiente heads NOPD's three-man special-events unit. At 55, he's a year from retirement. Less than a year—"the day after next Mardi Gras." But Valiente isn't checking out just yet. For every event that comes through town, he and his team put together what's known as an "incident plan," a tightly scripted logistical blueprint for how things should go down, which is disseminated throughout the department. There is intense pressure to avoid fuck-ups or oversights. This is only the second Mardi Gras for reformist New Orleans mayor Mitch Landrieu and his police superintendant, Ronal Serpas, and the official Mardi Gras season, at least from NOPD's perspective, stretches almost two weeks before Fat Tuesday, featuring dozens of parades, large and small, during that time.
Which is to say nothing of Bourbon Street.
For Mardi Gras, Valiente's incident plan fills out an inches' thick three-ring binder. In these waning days, the local police are operating on little more than caffeine and instinct, officially clocking 12-hour shifts, but in reality logging anywhere from 12 to 16 job-related hours. Valiente refers to this grueling schedule as "Mardi Gras mode." You can spot the street cops by their Mountain Dew-colored vests, a recent implementation, which Valiente tells me "are great—they're working, man." The cops patrol on foot and on Segways, on motorcycles and horseback. They move parades and safeguard the French Quarter. Trapped inside squad cars, officers nip at water bottles—swallowing just enough to stave off dehydration, but not so much that nature calls (during Mardi Gras, it isn't just the drunken tourists who suffer from a lack of loos).
Put on by glorified social clubs, known as krewes, the parades are chief Mardi Gras attractions. As of this morning, there are still two major processions left to march: Zulu and Rex. Both will be departing from within a few blocks of each other, on Claiborne Avenue, which is where Valiente now parks his vehicle. He leads me into the Krewe of Rex's den, an enormous warehouse space, at the corner of Third, where they have all their floats stashed. James Carville is onsite, glad-handing with Rex royalty and faux-flashing passing motorists. Dude is positively set to cut loose. "People come here to vent," says Valiente. "It's a weird town." I duck into an adjoining room, a changing area stuffed with racks of silk and sparkles, bins of masks and feathers—a Liberace wet dream. Outside, the temperature is quickly gaining momentum. Mercury rising. It's not yet 9 a.m., and some folks already have booze-weary complexions. They're not going to make it. I've been separated from Valiente, though soon we reconnect. I'll be riding in Rex, he tells me. In the command van that leads the way.
"We have got to do something about these vests!"
Officer Ross Bourgeois, one-third of Lieutenant Valiente's special-events unit, steps back into the van, out of the humidity, and tears at the Velcro of his police vest. "They're not meant to be worn all day long," he moans.
Captain Mike Pfeiffer, commander of NOPD's crime lab, doesn't disagree. "I feel like I'm shrink wrapped," he says, tugging uncomfortably at his uniform.
"It's all cuz the people like it," chimes in Lieutenant Anthony "Buddy" Micheu, taking a break from the radio, where he's communicating with his motorcycle men. "They say, 'I like to see the police.' "
"That's a double-edged sword," Bourgeois sighs. "When you have plenty of police, it's great. When you don't, it's just as obvious. We're down a hundred policemen from what we had last year. Lost a hundred, hired zero. Well, just hired thirty."
The command van, a 1995 model with only 27,000 miles, is on loan from Louisiana State Police, and there are a dozen of us bouncing around the 35-foot vehicle, moving between the platters of fried chicken and coconut shrimp in back and the driver's cabin, where Sergeant Jerry Smith, from LSP, is rolling along slowly, at about 2 MPH, stepping on the brakes every fifty feet or so. Cedric Palmisano, EMS planning coordinator, is also on board, sucking at an electric cigarette and detailing all the various bumps and bruises that are turning up along the parade route.
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"Lots of lacerated eyebrows and ice packs as a result of thrown beads," he says.
Which reminds another passenger, an organizational member from one of yesterday's parades, about an incident. "Someone got hurt," he admits.
"Doesn't the law protect you?" asks Bourgeois.
"You gotta prove negligence."
Bourgeois nods. "That's hard to prove."
Some of the most common Mardi Gras injuries, according to Palmisano, come as a result of falling drunks, the aforementioned beads, and kids toppling off of ladders, where they've been perched for a better view. But that's never the extent of it. "We've already had one cardiac arrest today," he says. And over the weekend, after the Zulu ball, some guy "was having the big one, passed out in the driveway." He coded on the way to the hospital, but they got him back.
It's sort of a given that folks don't have their own safety in mind during Mardi Gras. Just last Saturday, Smith tells me, some drunk climbed the back ladder of the command van, to surf on the moving vehicle. Now the ladder is boarded up, and that idiot is facing charges of criminal mischief and public drunkenness.
Palmisano's radio crackles. A kid just got hit in the head, it seems, with a coconut—"an infant," he clarifies—which sparks a debate over whether Zulu, the krewe known for tossing coconuts, will be able to keep its insurance. "They've got to get rid of them coconuts," Bourgeois insists.
The van reaches the end of its route down Napoleon and turns left, onto St. Charles, the parade's main drag. We enter a locus of humanity, a tipsy but civil-looking crowd—we're still uptown; far from the French Quarter—and a few of us decide to get out and walk. Suddenly everything is surround-sound. Trash and beads litter the street, which smells like a mix of dreg-beer and horseshit. It isn't long before someone runs up, an older guy in a fleece vest and sunglasses, toting a Michelob Ultra. "Need a painkiller?" he offers.
I'm between Pfeiffer and Palmisano. No thanks.
"There are a lot of characters in this town. You learn who's harmless and not—body posture, eye contact. You see who's going to show and not show," says Pfeiffer. "The whole idea is don't escalate anything."
"I've only been in a handful of 10-55s," says Palmisano.
Pfeiffer explains that there are "two signals police use when they need help fast. One's a 10-55. The worst one is a 108—that means an officer's life is in danger. You get that and people start coming out of the woodwork." On cue, Pfeiffer's radio comes alive. Not a 108, it's a 94. "Ninety-four is a shot," he says. Gunfire, I ask? Yes, though it turns out to be the burners from someone's gas grill, and I feel weirdly disappointed. The officers probably do not.
The NOPD, after all, is perhaps the most scrutinized police department in the country. When you type "NOPD" into Google (and then hit space bar), the first search suggestion is "NOPD corruption." Last year, a 10-month federal investigation into the department revealed that officers partook in "unconstitutional conduct," including excessive use of force, unwarranted stops, searches, and arrests, and discriminatory practices. Like any police force, NOPD occasionally fails its citizens, but when it does, it tends to be in a high profile, headline-earning manner. Whether they've been under too high-powered a microscope since Katrina, as some honest Crescent City cops may feel, is beside the point on Mardi Gras—as Valiente puts it, "We've got some bad apples, but show me an institution that doesn't"—because NOPD has always had a single saving grace: its reputation as the "masters of crowd control."
According to Bourgeois, the secret to the department's success is simple: "We're tolerant," he says, "and that comes from experience." Pfeiffer is even more specific: "The first rule is don't over-police. People are out here to have a good time, use that to your advantage. The troublemakers, you go in and, like a swat team, you hit them. With flashing, you suppress it in family areas. In adult areas?" He covers his eyes, miming tunnel vision. "Once you're off the route for something like that, you're not there for safety issues."
Back in the van, we go by one family who practically has a full bar set up—they're passing around handles of Grey Goose and Bacardi. Bourgeois nudges me, points out the window. "We were talking about tolerance? No city in the world would allow that. And if we went and confronted them, it would start a riot."
Soon the Rex parade is entering Lee Circle, and as planned, has merged with Zulu. Things are picking up inside the command van, as well.
"We're right behind Zulu's ass," I hear Micheu say.
Palmisano gets a call. "Another seizure?"
"We're directly on their ass."
"That seizure I believe is a Tulane cheerleader."
Someone cracks wise: "Tulane lost again, huh?"
Someone else sighs: "I wish Tulane was better."
After the Rex parade disbands, Officer Bourgeois drives me down Iberville, toward the French Quarter, toward Ground Zero of Mardi Gras, toward Bourbon Street. On the outskirts, we encounter a chubby fella with far-gone eyes. He's sporting a crew cut, a tank top, and a tribal tat. He flags us down and bashfully asks where he might find the Hustler Club. "It's on Bourbon," Bourgeois tells him. "Go down and make a left."
The man looks confused, betrayed by this advice. "I thought I was on Bourbon," he says.
Happy Mardi Gras.
Personally, I don't see my first pair of (female) breasts until almost 5 p.m., and even those are basically a profile shot, some side boob. Along with Bourgeois, I'm pushing through the French Quarter foot traffic with two other cops, and I realize my travel party, decked out in neon lemon-lime vests, probably isn't helping anyone loosen their inhibitions, let alone bra straps. One of the officers sees a guy in a glitter Speedo whip out his Johnson—a big New Orleans no-no—but lets him off with a warning, informing the flasher that he wouldn't be able to convict him, anyway, "due to lack of evidence."
It will come as no surprise that a solid chunk of Mardi Gras arrests occur in the Quarter. A few of the most common charges: drunk in public, disturbing the peace (or whatever semblance of peace there is on Mardi Gras), and public urination. Officers I speak to concede that the restroom situation is less than fair for partiers, that the bars and clubs are running a merciless racket, because "when you drink beer you're only renting that beer." Still, if they catch you peeing, "we'll let you finish, but then we'll put the Roles on." There are paddy wagons that make regular deliveries between here and Central Booking, and over the weekend, the Orleans Parish Sheriff's Office, which runs Central Booking, sets up a station in the French Quarter, as well, to help handle the increased volume. Perhaps the worst offense you can commit is messing with a mounted officer's horse. "Fuck with the officer, but do not fuck with the horse," I am warned. According to Bourgeois, the demographic that behaves the worst in jail is drunken white women in their 30s and 40s. "They're uppity. Excuse me?" he says, mimicking their attitudes. "Honey, you're in jail. It's not Walmart."
After hoofing it a few more blocks, the officers decide to give me a balcony view. We enter a tourist-trap shop, a rat hole selling beads and novelty shirts and everything fleur-de-lis, and they let us through to the back steps, to the upstairs apartment, where we crash a bachelor party-in-progress, eleven guys from the Boston area who've rented the space for $1,500. From my new vantage point, I can see what Captain Pfeiffer had been telling me earlier about crowd dynamics. "It's like a river, there's a flow," he'd said. "Little eddies crop up when there's a problem or if someone's flashing. You have to control the disturbances to that flow." It is mesmerizing to watch. I would be content to stay here for hours, though I soon discover we are unwelcomed guests. "You leaving soon?" the groom-to-be asks me. "Because we were just about to smoke some weed."
The officers and I reenter the river of humanity, journeying further away from Iberville, and finally discover a woman beyond the moral-tightening effects of any color neon, vest or otherwise. She has the wild, standing-on-end hair of what I can only assume is recent electroshock, nipples for breasts, and a washcloth-sized loin cloth-slash-skirt. She's perched on a second-floor balcony and is grinding on a handrail. To her right, a middle-aged white woman with Harry Potter hair suctions her mouth to the exhibitionist's chest—I try to imagine these women in Walmart, bargain-hunting. The cops decide now would be a good time to turn me off Bourbon Street. We make a right on Toulouse, then another on Royal. A brass band is playing. From a balcony a handful of pranksters are dangling what appear to be furry puppet tails on fishing line. The crowd is hysterical to grab them. One house over, I see a wisp of a man materialize from behind translucent curtains. He looks pale, misunderstood. Next to me, a guy with long hair and a polo shirt glances up, sees the apparition, hollers to his buddies: "Does he look like a faggot or what?"
I look at my watch—shit. I'm late for jail.
As I wait to be buzzed into the secure sector of the Orleans Parish Intake and Processing Center (i.e. Central Booking), I notice a young woman being claimed by her father. He is not tall and has a pointy wolf beard, an oversized raincoat. The girl has a gash across her cheek. Before leaving, this man profusely thanks the female deputy behind the bullet-resistant glass, but she has not saved his daughter, and likely knows it. On the other side of this glass, where the deputy is sitting, there are signs taped up as reminders—"Do not take bond from American Bail Bonds"; "Only accept cash from B.B.C. Management Bail Bonds."
Chief Deputy Jerry Ursin is expecting me. He shakes my hand and offers to give me a tour, describing how, when arrestees arrive, they are sent down a sort of assembly-line penal process. They are searched and stripped of possessions. They watch a 12-minute orientation video. They are medically screened, given a bar code, a color classification on a scale of baby blue (for first-timers) to red (for old friends). The facility's color scheme, meanwhile, is jaundice and lima bean, and the high-ceilinged main room contains a swath of DMV-like seats—what they call "open-sitting lockup"—and two locked holding pens in back. "This was actually our kitchen warehouse," says Ursin. "FEMA converted it after Katrina."
By the open-sitting area, there are large-screen TVs, and anyone who isn't in for an aggravated charge, and isn't misbehaving, is allowed to remain cage-free. To my surprise, it seems like a slow day, and Ursin tells me that arrests actually go down on Mardi Gras day. "The police are tired," he says, by way of explanation. Though he adds that, as of 5 p.m., the Sheriff's office had booked 1,164 people since the start of the season, which is a 5% jump over last year. To prepare for Mardi Gras, the IPC typically doubles its weekly supplies.
A little before 7p.m., Ursin has to leave and passes me off to one of the Sheriff's sergeants. Together we wander through the main room, as recent arrivals twitch and slump in their seats. The female holding pen is almost empty—just two women asking for blankets—though the male cell is roiling with boredom and grief. Some inmates itch inside their starchy orange jumpsuits. Others lie down, using toilet paper rolls as pillows, hunting for an ounce of comfort. I walk up to the cage, to see if anyone wants to talk. Many do.
"I was at Harrah's, the casino, then I woke up in jail," one guys tells me. "I'm getting out tomorrow, only minor charges." When I ask him what he's in for, he has to check his paper. "Uh, resisting arrest—see I don't remember none of this—disturbing the peace, and public drunkenness. In a casino. I don't understand how you disturb the peace in a casino." The next person I talk to, a clean-cut athletic type in the Abercrombie mold, tells me how he was walking back to his hotel with a co-ed but got distracted from his mission when they stumbled upon another couple. The woman was on the floor crying. She looked abused. "So I stepped in," he says. Turns out: not a mark on her.
I'm surprised at first that these men want to speak with me from the other side of the bars. Perhaps they're looking for an ally, a scrap of understanding. I am a stranger, I suppose, as good as anyone. Captain Pfeiffer had told me that this is a place where individuals can "drop off the map," if they can't post bond—an amount that typically ranges from $300 to $2,500, for municipal charges.
So what are some of the others in for?
"DWI, which was stupid of me. I should have given my keys to a friend or something."
"I got caught with a firearm."
"My chick lied."
"I was just chilling in the cut, rolling up a blunt, and the cops came out of nowhere, with their Tasers out."
"The cops saw me picking up an iPhone and they told me I stole it."
"I'm too wild. I smacked a dude with a beer bottle."
This last man, with a shaved head and twisted teeth, seems more at ease in convict clothes than most of the others, and he tells me that he was just released, in 2011, after serving a ten-year prison term. I speak to him longer than anyone, because he seems most desperate for a connection. "I haven't slept since Friday, just been popping Adderall and drinking beer. I hope they just drop this shit," he says, his voice then softening to a whisper. "That's not bad, though, right? Hitting someone with a beer bottle. Does it sound bad?" I tell him that, yes, to me it sounds bad. I ask how it sounds to him. He sighs. "My record's fucked up, man. It sounds fucked up."
The total number of arrests during the Mardi Gras season fluctuates from year to year, with two major influencing factors: the weather and the date. (The later Mardi Gras falls, the more it aligns with college spring breaks.) My cab driver doesn't believe that I am not among 2012's statistics when he picks me up from Central Booking. His name is Smain, he is from Algeria, and he is used to making this run, retrieving Mardi Gras washouts.
"So what'd you do?" he asks me, as we pull away.
"Me? Nothing."
"Come on."
"Really," I tell him. "I'm just a reporter."
"I am."
"Are you serious?"
He is very impressed that the Sheriff's office allowed me into Central Booking, and asks a few questions about the place. I tell him what I can. "The people fight too much. You can tell from the face," he agrees.
We fall into silence and I complain about the humidity, which hits a nerve: "You got to take at least shower a day, minimum. Swear to God." And then he begins to tell me about his own crazy Mardi Gras experiences over the years, like the time a couple got into the backseat and offered him $500 just to drive up and down Tchoupitoulas Street and "let us do the sex." And the time he picked up "a gay guy, who was gay," and who offered to give Smain $50 if he would let him suck his dick. In fact, just last weekend, he tells me, he drove a girl to New Orleans East, who tried to pay him with drugs and flesh. "I say no, that's not me."
By the flickering passes of yellow streetlight, and in the same backseat Smain refused to let two punch-drunk would-be lovers "do the sex," I scribble in my notepad. What are we trying to accomplish with all this Mardi Gras business, I wonder? Why do grown men, with gray hair and wrinkled skin, dress up in doctors' smocks and wear nametags that read: BREAST EXAMINER? What gives us such presumed license to misbehave? To not know our own limits? Are we so desperate for each other's debasement? For our own? Are we so repressed? Lonely? What?
"We're here," Smain says. I pay him with American currency.
A few hours later, minutes before midnight, I make it back to the French Quarter, to walk with the police down Bourbon Street, a procession that signifies the end of Mardi Gras, the last parade. The crowd is crammed onto the sidewalks, cheering wildly for our convoy, for the boys in blue, but is hardly dispersing. We'll tell you when Mardi Gras is over, they seem to say. And the party will indeed go on for hours more, until the power washers hit the pavement, and the beads and the puke and the hangers-on are all rinsed away. I will not be awake for that. I turn back and head for Canal Street. There, at the very lip of the Quarter, I pass an out-of-tune jazzman blowing into his horn. This is my last image of Mardi Gras. He doesn't even have a tip jar, this man. He's just wailing his heart out. I take a picture and think: Surely one of us is missing the point.
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You are here » Convicts transported to Australia » New South Wales. » Royal Admiral » 01 July 1830. » Thompson, James.
Convicted at Warwick Assizes for a term of life on 27 March 1830.
James Thompson, one of 192 convicts transported on the Royal Admiral, 01 July 1830.
Convicted at Lancaster (Liverpool Borough) Quarter Session for a term of 7 years on 26 October 1829.
Transported by Sir Charles Forbes (01 April 1830.).
Convicted at Durham Quarter Session for a term of 7 years on 11 January 1830.
Transported by Manlius (23 April 1830.).
Convicted at Leicester Quarter Session for a term of 7 years on 11 January 1830.
Transported by Marquis of Huntley (05 April 1830.).
Convicted at London Gaol Delivery for a term of 7 years on 26 October 1791.
Convicted at Surrey Quarter Session for a term of 7 years on 01 September 1828.
Transported by Persian (26 June 1830.).
Convicted at Stafford Assizes for a term of life on 29 March 1828.
Transported by Florentia (11 August 1830.).
Convicted at Salop (Town of Shrewsbury) Quarter Session for a term of 7 years on 23 April 1830.
Transported by Earl of Liverpool (December 1830.).
Convicted at Monmouth Assizes for a term of 7 years on 22 August 1829.
Convicted at Somerset Quarter Session for a term of life on 11 January 1830.
Convicted at Middlesex Gaol Delivery for a term of 7 years on 10 September 1829.
Transported by Royal George (25 June 1830.).
Convicted at Middlesex Gaol Delivery for a term of 7 years on 29 October 1829.
Convicted at Leicester (Borough) Assizes for a term of life on 06 August 1830.
Transported by Red Rover (21 October 1830.).
Convicted at Oxford Quarter Session for a term of 7 years on 19 October 1829.
Convicted at Cornwall Assizes for a term of 7 years on 25 March 1828.
Convicted at Dorset Assizes for a term of life on 12 March 1830.
Transported by Burrell (22 July 1830.).
Convicted at Lancaster Quarter Session for a term of 7 years on 19 July 1830.
Transported by John (09 October 1830.).


Lack of anti-venom in rural areas and difficulty accessing health centres are among a number of factor contributing to 46,000 deaths every year.
NEW DELHI // Chirag Roy set off for the nearby Indian village of Kollara after receiving a call that fateful morning.
A spectacled cobra had been spotted in the neighbouring village, one kilometre away. Would he be able to come immediately?
As the resident naturalist at Svasara Resorts, in the Tadoba Tiger Reserve in eastern Maharashtra, Roy had wanted to rescue the snake. But that morning on March 1, he was bitten by the cobra and died on the way to hospital.
Roughly 46,000 people die of snakebites in India every year, according to the American Society of Tropical Medicine and Hygiene, accounting for nearly half of the 100,000 annual snakebite deaths the world over.
But most of these deaths are entirely avoidable, said Gerry Martin, a Bengaluru-based conservationist who works to reduce snakebite mortality.
A colleague had followed Roy that day, leaving Svasara minutes later after assembling a kit to rescue the snake. By the time he reached Kollara, Roy had been bitten by the cobra.
He was not bleeding, but he knew what had happened. "I need to go to a hospital," Roy told his colleague.
The nearest government hospital was 14 kilometres away, and the doctors there failed to see the urgency of Roy's condition. By the time he was given a shot of anti-venom, it was clear he needed further medical attention as he could not breathe and was vomiting.
An ambulance was parked at the hospital but its attendants were nowhere to be found.
Another van was commandeered, but the journey to the city of Nagpur took two hours. Roy died on the way, at the age of 30.
Roy's death was quite unusual, Mr Martin said.
The infrastructure to deal quickly and effectively with snakebites is often inadequate in rural areas. Roads to the nearest hospital may be bad or non-existent, so ambulances may struggle to get victims to health centres. In remote hospitals, stocks of anti-venom can run low.
But the real problem, Mr Martin said, is a lack of awareness.
In villages where snakes are common visitors, victims tend to ignore bites, presuming they were bitten by non-venomous snakes. Often, they turn to faith healers or local medicine men instead of seeking prompt medical treatment.
Even more egregious, Mr Martin said, is how ill-equipped doctors and medical staff are to treat snakebite.
He recalled the case of a nine-year-old girl who went to a government health centre after being bitten by a Russell's viper – considered one of the most dangerous snakes in Asia.
In reality, snakebite is not a medical enigma. Anti-venom, administered at the right time, is sufficient to negate the effects of the bite.
Polyvalent anti-venoms can neutralise the effects of venom from multiple species of snakes.
The process of producing anti-venom is straightforward but painstaking, said M V Khadilkar, a veterinary doctor who co-founded Premium Serums and Vaccines, one of India's leading manufacturers of anti-venom.
Even today, nearly all of the world's anti-venom is generated by injecting horses with sub-lethal doses of snake venom. The horses produce biological agents – or antibodies – to fight off the effects of the venom. These antibodies, which can be collected from the horses' blood, form the raw material of anti-venom.
A few years ago, a vial of anti-venom cost roughly 1,000 rupees (Dh55). "In 2014, the government started to control the price of anti-venom, and the price of a vial has now been fixed at 600 rupees," Mr Khadilkar said.
But Mr Martin argued that India had enough anti-venom. What it lacks is distribution – the ability to get anti-venom on to the shelves of every government health centre and hospital in the country, particularly in rural areas. Anti-venom must also be stored in refrigerators, but this is a problem in a country where power supply can be erratic, especially in rural areas.
In the case of the nine-year-old girl who died, even if her first doctor had run short of anti-venom, he could have sent her in an ambulance to another hospital that still had a stock of the drug.


During the 2017 event donations were received from 42 states! How many states did your organization receive donations from? How many could you receive donations from? There are many people who may no longer live in Warren County who still appreciate the good work your organization does and will support you – if you ask. Reach out to those you know. Email, phone, Facebook – spread the word. $10 is all it takes and the online giving is so quick and easy regardless of where you live.
As an added incentive the organization that receives donations from the most states will receive an incentive prize of $100. States will be determined by the credit card billing address of donors. Ties will be broken by total number of donations and then by total dollars donated.
Winner will be determined as a percentage, year over year. The incentive prize for the winning organization is $100. Ties will be broken by total number of donations.
It's a mystery but any organization could be the winner – everyone has an equal chance of winning but you must be present at the check ceremony to take home the $100 prize! If the winner is not present at the ceremony another winner will be announced until awarded.