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'Next generation' precision medicine for cystic fibrosis wins prestigeous drug discovery award
Published: 14 Dec 2016 in Society news
A new medicine to treat cystic fibrosis has received Drug Discovery of the Year 2017, a prestigious award from the British Pharmacological Society. A combination of two drugs (lumacaftor and ivacaftor) offers a significant step forward for the treatment of this life-limiting, inherited disease. The award is made to the team of researchers at pharmaceutical company Vertex Pharmaceuticals, which is responsible for the development of lumacaftor/ivacaftor, in recognition of the drug offering an innovative approach that addresses a significant unmet medical need.
Cystic fibrosis is a genetic disease that can cause the lungs and digestive system to become clogged with thick, sticky mucus. Over time, the lungs become increasingly damaged and prone to chronic infection, and they may eventually stop working properly. A number of treatments are available to help reduce symptoms, but unfortunately average life expectancy is reduced for people with cystic fibrosis.
It is estimated that there are over 70,000 people with cystic fibrosis worldwide[i], and 1 in every 2,500 babies born in the UK has the condition[ii]. Children with cystic fibrosis inherit a defective or missing protein – known as CFTR – resulting from mutations in the CFTR gene. There are approximately 2,000 known mutations in this single gene.
Lumacaftor/ivacaftor is an example of precision medicines: it responds to one type of CFTR gene mutation in patients with cystic fibrosis — treating the root cause of the condition, rather than just focusing on symptoms. Patients in clinical trials experienced improvements in lung function and body mass index (BMI) scores. Lumacaftor/ivacaftor was approved for use in people over 12 years old with this gene mutation in the USA and Europe in 2015.
"By tackling the underlying causes of the disease, lumacaftor/ivacaftor marks progress in the development of the next generation of treatments for cystic fibrosis. The British Pharmacological Society is pleased to make this award to the team at Vertex Pharmaceuticals for their contribution to our understanding of precision medicines in the treatment of cystic fibrosis," said Dr Tom Blackburn, chair of the British Pharmacological Society's judging panel.
He added, "The British Pharmacological Society celebrates the importance of pharmacology in drug discovery and the benefit of this research to society. The life expectancy for someone with cystic fibrosis was 18 years old in the 1980s, but even in 2016 around half of patients die before their 41st birthday. Life expectancy will only continue to improve as the pharmacology community makes further advances in the treatments available to people with this life-limiting condition."
James Barrow, Head of External Affairs at the Cystic Fibrosis Trust, commented: "The drug is an exciting breakthrough in the treatment of cystic fibrosis. It's the first time that two compounds have worked together to improve the function of the most common CFTR mutation. It is already transforming the lives of thousands people living with cystic fibrosis."
The Drug Discovery of the Year award is being presented by Professor David Webb, President of the British Pharmacological Society, to the Vertex Pharmaceuticals team during the Society's annual conference, Pharmacology 2016.
[i] Sosnay PR et al. Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene. Nat Genet. 2013;45(10):1160-1167.
[ii] NHS Choices. Cystic fibrosis. Available online: http://www.nhs.uk/Conditions/Cystic-fibrosis/Pages/Introduction.aspx
BJCP article: Greater efforts are needed to encourage patients to report adverse drug reactions
BJCP article: Efforts Are Needed to Optimize the Use of Biologics for Treating Patients with Rheumatoid Arthritis


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A STUDY ON THE IMPACT OF REPEATED FREEZE-THAW CYCLES ON THE SERUM CYTOKINE ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)
Moses D Lugos *, Umanka Y Polit, James G Damen
ABSTRACT:Sandwich ELISA is a modified form of the standard ELISA technique used by researchers and in routine laboratories for detecting and quantifying specific analytes in samples. This study is designed to evaluate the impact offreeze-thaw cycles on the results of serum cytokine measurement by sandwich ELISA technique. Serum samples were collected from four healthy donors and stored in 3 aliquots at -80oC for three days per thaw-freeze cycle. The concentrations of IL-4, IL-6, IL-8 and IL-9 in the aliquots of serum samples exposed to one, two and three freeze-thaw cycles respectively were determined. Data shows an increase in the cytokine levels following two and three freeze-thaw cycles compared to the expression levels obtained after one freeze-thaw cycle (baseline). The increases reported are as follows: IL-4; 6.56pg/ml (19%) and 3.52pg/ml (10%), IL-6; 103pg/ml (20.9%) and 24.6pg/ml (5%), IL-8; 105.05pg/ml (14%) and 102.76pg/ml (11%) and IL-9; 117pg/ml (17.77%) and as high as 312pg/ml (47.52%) respectively. These results suggest that the repeated thawing and freezing of serum samples can alter the values of serum cytokines measured by ELISA, in most cases with an increase. The reasons for the increase in the values of these cytokines following repeated thawing and freezing have not been investigated. To minimize the effects of thaw-freeze cycles on serum cytokine ELISA, fresh serum samples should be used for the analysis of serum cytokines. Alternatively, aliquots of serum samples can be stored in the -80°C Freezers for single use or by the application of a methodology that will subject samples to similar treatments, for instance, analysing several samples in parallel as in Multiplex assay. These approaches will minimise variations due to repetitive freeze-thaw cycles.
KEY WORDS: Sandwich ELISA, Freeze-thaw cycles, IL-4, IL-6, IL-8 and IL-9
Van Weemen, B. and A. Schuurs, Immunoassay using antigen—enzyme conjugates. FEBS letters, 1971. 15(3): p. 232-236.
Nakamura, R.M. and W.R. Dito, Nonradioisotopic immunoassays for therapeutic drug monitoring. Laboratory Medicine, 2016. 11(12): p. 807-817.
Robinson, D.L. and J.M. Lau, Assessment of an ELISA laboratory exercise. The american biology Teacher, 2012. 74(8): p. 558-563.
Hornbeck, P.V., Enzyme‐linked immunosorbent assays. Current protocols in immunology, 2015. 110(1): p. 2.1. 1-2.1. 23.
Aydin, S., A short history, principles, and types of ELISA, and our laboratory experience with peptide/protein analyses using ELISA. Peptides, 2015. 72: p. 4-15.
Gan, S.D. and K.R. Patel, Enzyme immunoassay and enzyme-linked immunosorbent assay. J Invest Dermatol, 2013. 133(9): p. e12.
Thakur, K., et al., Revisiting the dilution factor as vital parameter for sensitivity of ELISA assay in CSF and Plasma. Annals of neurosciences, 2015. 22(1): p. 37.
Bullock, S.L. and K.W. Walls, Evaluation of some of the parameters of the enzyme-linked immunospecific assay. Journal of infectious diseases, 1977. 136(Supplement 2): p. S279-S285.
Miura, K., et al., Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines. Vaccine, 2008. 26(2): p. 193-200.
Cox, K.L., et al., Immunoassay methods. 2014.
Engvall, E. and P. Perlmann, Enzyme-linked immunosorbent assay, ELISA III. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. The Journal of Immunology, 1972. 109(1): p. 129-135.
Plikaytis, B.D., et al., Comparisons of standard curve-fitting methods to quantitate Neisseria meningitidis group A polysaccharide antibody levels by enzyme-linked immunosorbent assay. Journal of clinical microbiology, 1991. 29(7): p. 1439-1446.
Flynn, S., et al., Factors affecting enzyme-linked immunosorbent assay (ELISA) for insulin antibodies in serum. Clinical chemistry, 1981. 27(10): p. 1753-1757.
Reverberi, R. and L. Reverberi, Factors affecting the antigen-antibody reaction. Blood transfusion, 2007. 5(4): p. 227
Le Bon, A. and D.F. Tough, Links between innate and adaptive immunity via type I interferon. Current opinion in immunology, 2002. 14(4): p. 432-436.
Zhou, X., et al., Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research. Current opinion in clinical nutrition and metabolic care, 2010. 13(5): p. 541.
Lee, J.-E., S.Y. Kim, and S.-Y. Shin, Effect of repeated freezing and thawing on biomarker stability in plasma and serum samples. Osong public health and research perspectives, 2015. 6(6): p. 357-362.
Pinsky, N.A., et al., Effect of multiple freeze-thaw cycles on detection of measles, mumps, and rubella virus antibodies. Clinical and diagnostic laboratory immunology, 2003. 10(1): p. 19-21.
Aziz, N., et al., Analytical performance of a highly sensitive C-reactive protein-based immunoassay and the effects of laboratory variables on levels of protein in blood. Clinical and diagnostic laboratory immunology, 2003. 10(4): p. 652-657.
Wang, J., et al., Effects of storage conditions on the stability of serum CD163, NGAL, HMGB1 and MIP2. International journal of clinical and experimental pathology, 2015. 8(4): p. 4099.
Kragstrup, T.W., et al., A simple set of validation steps identifies and removes false results in a sandwich enzyme-linked immunosorbent assay caused by anti-animal IgG antibodies in plasma from arthritis patients. Springerplus, 2013. 2(1): p. 263.
Lugos MD, Polit UY, Damen JG; A study on the impact of repeated freeze-thaw cycles on the serum cytokine enzyme-linked immunosorbent assay (ELISA). Int. J. Med. Lab. Res. 2018, 3(2): 29-36

redpajama_set_name: RedPajamaCommonCrawl


Your vote means nothing…it is how the SOS reports the vote…And you believe them? | Scanned Retina – A Resource for the People!
← Contrary to what we had been told…more misrepresentation?
Your vote means nothing…it is how the SOS reports the vote…And you believe them?


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La A13 è un'autostrada che percorre da nord a sud l'intera Svizzera orientale, da Sankt Margrethen, cittadina ai confini con l'Austria, fino ad Ascona, sul Lago Maggiore. Il suo tratto alpino più impervio non ha caratteristiche autostradali, bensì semiautostradali (carreggiata unica senza incroci a raso, quasi sempre con un'unica corsia per senso di marcia); tale tratta è comunque sottoposta a pedaggio in quanto interdetta ai pedoni e ai veicoli privi di motore, e consente limiti di velocità piuttosto elevati, in genere sui 100 km/h.

La A13 comincia come detto a Sankt Margrethen dalla congiunzione con la A1 e il futuro raccordo autostradale con l'Austria. Prosegue verso sud costeggiando il Reno e il Principato del Liechtenstein. Nei pressi di Sargans si collega alla A3 proveniente da Zurigo. Da qui si entra nel Canton Grigioni lambendone la capitale, Coira, pochi chilometri dopo la quale l'asse viario si riduce a una semi-autostrada. Da questo punto il percorso assomiglia molto di più a una seppur larga e comoda strada di montagna che a una superstrada, essendo permesso il sorpasso invadendo l'opposto senso di marcia non essendoci spartitraffico.

La strada costeggia quindi la cittadina di Splügen da cui nei mesi estivi si può raggiungere l'omonimo passo di confine con l'Italia e quindi imbocca il Tunnel del San Bernardino, lungo 6,6 chilometri, da cui si sbuca nella Svizzera Italiana. Discesa la valle Mesolcina grazie a numerosi tornanti, poco dopo Mesocco l'arteria riprende la struttura autostradale. Termina quindi provvisoriamente il suo percorso immettendosi nell'A2, per il San Gottardo a nord e il confine con l'Italia a sud.
Una seconda tratta comincia presso l'aeroporto di Locarno per terminare, con 2 lunghi tunnel attraverso Locarno e Ascona, a sud di Ascona sul Lago Maggiore.

Percorso
Percorso: Sankt Margrethen - Buchs - Sargans - Landquart - Coira - Thusis - Splügen - Hinterrhein - San Bernardino galleria e passo - Mesocco - Roveredo - Bellinzona.
Locarno - Ascona.

 (1) Entrata e uscita solo in direzione nord
 (2) Entrata e uscita solo in direzione sud
Limiti di velocità: 120 km/h nelle tratte autostradali; 100 km/h (talvolta 80 km/h sulle parti semi-autostradali).

Pedaggio: compreso nella vignetta annuale.

Tangenziale di Locarno

La sezione di A13 che passa tangente alla cittadina di Locarno ha inizio ad est dell'abitato, da una rotatoria sulla strada cantonale 406, a 10 km dallo svincolo di Bellinzona Sud dell'autostrada A2. La A13 cantonale locarnese è classificata come semiautostrada e dopo un percorso di 9,5 km termina al ponte sul fiume Maggia dove il cambio di segnaletica indica l'inserimento sulla Strada principale 13 per Brissago.

Note

Voci correlate
 Strada principale 13
 Viamala-Brücke
 Ponte Cascella
 Ponte Nanin

Altri progetti

Collegamenti esterni

A13
Trasporti nel Canton Grigioni
Trasporti nel Canton San Gallo
Trasporti in Canton Ticino

redpajama_set_name: RedPajamaWikipedia


A healthy diet contains a variety of different types of foods to help our bodies receive the vitamins and minerals it needs to function properly.
As much as we may enjoy one or two specific foods, we know (at least I HOPE we know!) that a diverse diet is a necessity for optimal health.
The same applies to our running "diet." As runners, we need to incorporate different types of workouts into our training schedule in order to help us minimize our risk of injury while maximizing our progress toward our goals.
There is one type of workout that many of my running friends tend to undervalue in their training, and that is the easy run.
There are many benefits of running at an easy pace, no matter what your running goals might be.
If you think running easy is of little value, here are just a few of the changes you can see by slowing down during some of your workouts.
Reduced Risk of Injury: Running at a high intensity is hard on the body, and if you do it too frequently, you definitely increase your risk of sustaining an injury that may force you to miss several weeks (or months) of training as you heal. Easy days allow you to get time on your feet and miles under your belt with much less stress and strain on your body.
Higher Quality Hard Workouts: In order to get the most benefit out of your hard workouts (repeats/hills/tempo runs/etc.), you need to be able to run them HARD! If you're not keeping your easy runs easy, you are likely to already be fatigued going into your hard workouts which will minimize the effectiveness of those workouts. Running easy allows you to be able to really hammer your hard workouts and get the most out of them.
Increased Endurance: Most runners don't need to run faster in order to race faster. What they need to do is be able to maintain a faster pace for a longer period of time. Running at an easy pace for long periods of time will build that endurance so that on race day you will be better suited to hold your goal pace from start to finish.
Improved Muscle Memory: The more we run, the better we get at it. That's because our bodies become more adept at putting one foot in front of the other over and over again. Improving our muscle memory allows us to become more efficient runners over time.
Long story short, as counterintuitive as it may seem, slowing down during the majority of your training runs will absolutely help you become a better runner!
That said, it does take some time to see the improvements associated with running easy, so you need to be patient and trust that what you're doing will pay off.
You won't notice much of a change after a few weeks.
You may not notice much change in a few months even.
It's taken me almost a full year of slowing down to see the benefits to my endurance and my top speed, but there is no question that it is working for me.
If you'd like more information and some of the science that backs up the notion that slowing down will make you faster, check out the book 80/20 Running by Matt Fitzgerald.


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text:
S5W-11433: Richard Lochhead (Moray)
To ask the Scottish Government what progress it has made with the installation of cycling facilities at railway stations (a) nationally and (b) on the Aberdeen to Inverness line.
Answered by: Humza Yousaf 4 October 2017
My officials at Transport Scotland engage regularly with ScotRail on progress being made to install cycle parking facilities at railway stations. Since the franchise commenced in April 2015 nearly 1,300 additional cycle parking spaces have been rolled out at 44 stations, including Elgin and Inverurie on the Aberdeen to Inverness line. Proposals are currently being developed for additional cycle parking facilities at Dyce, Aberdeen and Inverness station.
ScotRail has also rolled out the Bike and Go hire scheme at 12 stations including at Aberdeen and Inverness station.


The Board of Ascent Resources plc, the European focused oil & gas exploration and production company, is pleased to provide an update on progress with its Petisovci project in Slovenia.
The completion of the necessary infrastructure is progressing well. The line from the CPP to the export line has passed the technical inspection and is ready for use. Refurbishment of the separation equipment at the CPP has progressed as planned. The refurbished separator has been installed and the remaining connections are being made.
The flowline from Pg-11A to the CPP has been installed, tested and is ready to connect to the well once downhole operations have completed.
Our customer, INA, is due to complete the re-certification of its pipeline on the Croatian side of the border in time to receive Petisovci gas, we have been advised to expect this before the end of July 2017.
Work to bring Pg-11A into production continues.
As previously announced we engaged a coiled tubing unit to assist with the part of the final downhole portion of the recompletion. This part of the operation has been completed and the coiled tubing equipment has now left the site. Additional work is required to prepare the well for production, which is expected to take approximately two weeks.
Once the work-over is complete we will immediately connect the well to the infrastructure, enabling gas to be produced for sale. The Company looks forward to providing an update once these works are completed.
"We have made significant progress over the last three weeks in getting the infrastructure ready and look forward to commencing the supply of gas to INA shortly."


Located right between an old Turkish village and an abandoned Greek village ruins, one of the stops of the antique Mimas-Efes hiking route. It's a place like eagle's hen located on a small hill. Away from all the noise, with the sound of goats and bells, a place with a breeze of the hills during summer. All rooms are located with 180 degree angles which gives a view to mountain, sea, town lights and unique sunrise. For the internal design, nothing is bought. Everything is made in our workshop with natural materials. Exciting rooms which are full of energy with not exaggerated, humble and small details. With the works of the artist Ayhan Tomak, beds, sinks and tables also provide nice solutions for the enviroment. All the marmelades, olives, olive oils etc. are made by us. If you wish, you could purchase thoose products. For the dinner, you enjoy your meal and drink accompanied with a great view and the moonlight.


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Home /City of Montevallo establishes trial program for public transportation
LocalAugust 21, 2018
City of Montevallo establishes trial program for public transportation
A Montevallo Area Express bus stops outside Napier Hall. Photo by Waid Jones
As students move back onto the University of Montevallo's campus, they may notice signs proclaiming, "It's time to ride." These are signs denoting the pickup locations for the City of Montevallo's new pilot program for a bus system called Montevallo Area Express, or MAX for short. This experimental program took its maiden voyage on Monday, Aug. 13, just a week before students began returning to the University.
The bus system is a partnership with the Birmingham-Jefferson County Transit Authority to provide public transportation for Montevallo. The system is free to ride during the pilot program, which will end at the beginning of 2019, and covers many of Montevallo's most important stops.
The bus route currently has stops on Main Street, as well as at Meroney House, the McChesney Student Activity Center and Napier Hall. The route also includes both Oak Park and Cobblestone Apartments and will run from 7 a.m. to 8 p.m., seven days a week. In total, the loop should take approximately 30 minutes from beginning to end, and can be monitored using the myStop Mobile app. The app also provides an approximation of the bus's current location, as well as departure and arrival times for all the stops on its route.
The buses themselves, as well as all stops, are ADA compliant and allow for wheel chair access. Buses additionally allow passengers to stow bikes on board to aid with longer journeys. Free Wi-Fi will also be available for passengers while on the bus.
The entire route, as well as the bus's schedule, is available on the City of Montevallo's website and will be posted around town. Mayor Hollie Cost hopes to encourage Montevallo citizens to embrace riding the bus instead of walking everywhere, an issue she noted on the bus's maiden voyage as one of the program's key struggles.
In a press release regarding the new program, the city stated it hopes the bus system will help citizens cut down on using their vehicles to make short trips and will allow for the city to be more environmentally conscious, saying, "on average, bus transit routes produce 33% less greenhouse gas emissions than single occupancy vehicles."
At a City Council meeting the night of the inaugural voyage, the council appeared optimistic about the success of the program and its ability to help the community and their constituents.
"I think it's a great opportunity for Montevallo to have a transit system," said Jason Peterson, City Council Member for District 4, adding, "I hope we can expand it more." Peterson also stated that he hopes additional stops can be added into more residential areas.
In a Public Transit Meeting held July 16 at Montevallo's City Hall, Mayor Cost stated, "We need to look at the ridership and see how it best services the community," when asked about adding more stops and investing city money into the program.
During the pilot program the city will be monitoring the success and use of the bus system so they can better tailor it to the needs of the community. Some changes have already been proposed, with more stops planned to be added on Highway 25 by the end of September.
TAGS: city of Montevallomontevallo area expresspublic transportation
Waid Jones
Waid Jones was the editor-in-chief of The Alabamian during the 2019–2020 academic year. In 2018, while managing editor of The Alabamian, he received the Veterans of Influence Rising Star Award from the Birmingham Business Journal. Prior to coming to UM he was in the U.S. Marine Corps for two and a half years. Jones graduated with a degree in political science from UM in 2020. He is currently the news editor for the Jackson County Sentinel in Scottsboro, Alabama.
https://www.thealabamian.com/author/waidjones/
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Now we are going to provide you the very handsome Free Photo Frame Mockup PSD that will elaborate all the specifications that you required. This is the best for your photos and the images and you will find a huge bundle of attraction in it. Via smart-object layer you can place your desire image or picture. Like our every design, we have made it as best as the requirement of this age and you will love it.


(January 15, 2018) Blast off with our newest Flash Giveaway contest! 2018's First Man landed a Rotten Tomatoes critics score of 88-percent (stay tuned for Michael Scott's exclusive review, due soon), making it a very compelling film. And to celebrate the film's disc release, Universal Studios has given AV NIRVANA one Blu-ray and one 4K Blu-ray copy to give away! That means we'll select two lucky winners!!
Much like past Giveaways, anyone can enter (you only need to be a member of AV NIRVANA, which is 100% free). So, if you're not a member, your first step is to register.
Step two, enter the contest by leaving a comment below!
Follow those steps and you'll gain one entry into the contest.
Best of luck to everyone that enters and here's a special thanks to those members that have made AV NIRVANA their home theater destination! If you would like to become a supporter of our community, click here for more information.
The contest runs from January 15, 2019 through January 25, 2019 (9:00AM EST).
Two winners will be selected at random and announced in this thread. The first drawing will select the Blu-ray winner. The second drawing will select the 4K Blu-ray winner.
The Blu-ray disc will ship direct from Universal Studios, the 4K copy will ship via Media Mail.
There's still time to enter our Halloween giveaway!
Hopefully you're name gets drawn second!
I'm in. I am interested in the video quality. Space movies of late have had great video and audio. Plus the film looks solid.
Awesome- Count me in Todd!
So cool! I loved the movie! So count me in!
I've REALLY been looking forward to this one so please count me in. Thanks again for these great giveaways.
JBrax and jdubs75 like this.
I did not know about this give-away or I wouldn't have just ordered it and saved money when I won.
I watched First Man in HD last night. An excellent film.
I would love to win the 4K and rewatch a few more times.
Put me down to win the 4K.
If I'm only half lucky and win the HD, you can put it up again. BUT if my name pops up for the 4K, I WANT. I really want.
This contest is LOCKED! Drawing in a second!
Mind boggling how good the odds are. Amazingly, this contest had thousands of views on Twitter alone... not to mention other social media and here on the site. I guess folks aren't interested in free flicks? Kudos to our members who are loving throwing their hat in the ring! We appreciate all of you and enjoying running these contests to drop a little joy into your home theater lives!!
Ok... Siri is going to pick our winners. First up is for the Blu-ray copy!
LOL. #11 is the pick. The Champ.
Pick number 2 is #14! TrippleJ is in the winners circle!
TrippleJ, I think you had said Blu-ray only. If you want to talk with JBrax and do a flip, you can. If you guys want to chat, then contact Michael Scott to let him know?
Not jbrax again. No one can be that lucky.
I'll happily swap if you like @tripplej! Thanks yet AGAIN A/V Nirvana for these incredible giveaways.
Wow, so exciting! Thanks for the opportunity and for the giveaway.
I will gladly accept the blu ray version.
Sweet! If you don't mind shoot Mike a message letting him know you're ok with the swap and thank you.
Sure. I don't have 4K TV or player or anything that supports 4K so 1080p blu ray is all I need.


text:
Leo Wilhelm Wilkens (25 de noviembre de 1893-4 de enero de 1967) fue un deportista sueco que compitió en remo como timonel. Participó en los Juegos Olímpicos de Estocolmo 1912, obteniendo una medalla de plata en la prueba de cuatro con timonel.

Palmarés internacional

Referencias

Remeros de Suecia
Remeros en los Juegos Olímpicos de Estocolmo 1912
Medallistas olímpicos de plata de remo
Medallistas olímpicos de plata de Suecia
Medallistas olímpicos de plata de Estocolmo 1912
Suecos del siglo XX
Nacidos en Malmö
Fallecidos en Greenwich (Connecticut)


rec. 1956, location not given.
A CD at full price with little more than 30 minutes duration? Well, this is something rather special for collectors. If like me you've known and loved these pieces through recordings such as that on EMI conducted by Leonard Bernstein – also recorded with a pungently expressive French orchestra – then you will certainly be curious as to how the composer himself conducted these works.
With Le boeuf sur le toit, Milhaud leaps out at us from behind the curtains with theatrical verve, keeping up a high tempo in the more lyrical sections where Bernstein has a tendency to stretch and pull things around more. This immanent urgency brings the work in at a good 3 minutes under Bernstein's timing. The orchestral playing is tremendously vital, and even with a certain amount of distortion at peaks and one or two audible edits, this is a performance to which you just have to move about. The subtitle Cinema-Symphonie was never more appropriate than here, with the mind constantly conjuring images of hobbling donkeys, brash and colourful South American characters, dusty days and sultry nights.
La création du monde is full of heartbreakingly beautiful and thrilling music, and if you don't know it you must go out and find yourself a recording as soon as possible. Bernstein's version is my favourite. There is another one on the Naxos label with the Orchestre National de Lille (see review) which is OK, but doesn't have quite the emotional impact of either Bernstein or the present recording sous la direction de l'Auteur. That saxophone solo in the beginning just has to be played with plenty of eloquent vibrato, which we find with both Bernstein and Milhaud. Detail in the recording is better with Bernstein as you would expect, and you have to put up with that distortion as well at times with the present disc. The André Charlin release doesn't go in for information about mastering or sources, though as the original engineer one has to assume these are taken from master tapes. There is a little hiss on the recording which is no problem at all, though the emphasis is more on the treble in terms of balance. Milhaud doesn't obtain quite the jazzy swing Bernstein obtains during all that counterpoint which develops in the first five minutes or so, and with a thinner bass presence the embrace of the pedal tones and bass lines over which the harmonies turn and grow is more distant and less effective. The percussion section of the Champs Elysées orchestra seems to suffer collective anticipatory rush-itis, and one can sense their collective heads buried in their parts, the poor conductor cast adrift after each initial cue. Bernstein's control in this department is most certainly superior. All of this taken into consideration, there is a magic about this performance which transcends technical criticisms, and it has to be said, this is a unique document which breathes the same air and generates a similar atmosphere of adventure and discovery as some of Stravinsky's original recordings, and as such deserves a similar status.
These are not to be confused with the mono recordings Milhaud made with the Concert Arts Orchestra in 1954 which are now available on EMI. There are great things on that CD (CDC 7 54604 2 also in the Composers in Person box), and while the recording of La création du monde is definitely inferior the Champs Elysées recording Le boeuf sur le toit sneaks in as the last track, so it has to be worth considering. If you already have a favourite version of these pieces and aren't turned on by the historical resonances and irreplaceable sense or time and place generated by this kind of recording, then this is probably not going to be worth your while given the price. If however you seek that gritty feel of a period performance under the directorship of the composer, then this is the genuine article.


George Fox University's School of Physical Therapy presents the third annual event designed to impact Newberg and surrounding communities through nutrition, exercise and behavioral health classes.
All classes are free and open to the public. Events are scheduled at George Fox University's Roberts Center, located at 501 N. Villa Road, in Newberg.
Each day will be dedicated to a different aspect of health and wellness.
Learn about heart-healthy foods, calorie budgeting, how to read food labels, strategies on maintaining or getting to a healthy weight, and how to cook healthy meals. Participants will receive a folder with educational handouts that include healthy recipes and hands-on training through an active cooking session on site. Come and share a meal with us.
Spine/Back Care Class, 6 p.m.
Nearly 80 percent of the population will experience back pain in their lifetime, as pain is often provoked with various postures and movements. This class will focus on both acute and chronic low-back pain as well as providing state-of-the-art innovative strategies for maintaining a healthy back. Participants will experience moving better with less pain.
Behavioral Health Class, 6 p.m.
Learn simple and effective coping techniques to juggle the demands of life.
This class will focus on incorporating various exercises into a manageable lifelong habit. Several different classes will beheld concurrently and will be appropriate for all ages and abilities, covering topics such as balance, strengthening, aerobics, high intensity interval training, and yoga.
This event provides a fun and safe space for kids with special needs to swim, play and be well. Come join us for a fun pool party where kids can have support from physical therapy faculty and students.
Learn about heart-healthy foods, calorie budgeting, how to read food labels, strategies on maintaining or getting to a healthy weight, and how to cook healthy meals. A live cooking demonstration will be included.
This class will focus on both acute and chronic lowback pain and will provide state-of-the-art innovative strategies for maintaining a healthy back. Participants will experience moving better with less pain.
Are you ready to develop healthy habits? Learn about behavioral changes you can make to improve your quality of life. Plus, get tips on parenting the "tween" years and find out how stress impacts your body.
This class will focus on incorporating various exercises into a manageable lifelong habit. Classes will cover topics such as balance, strengthening, aerobics and yoga.
This is a semi-annual event that provides a fun and safe space for kids of all abilities to enjoy time in the water with support from physical therapy students. Come join us for a pool party where your kids can swim, play and be well!
Why a Health and Wellness Week?
62.2 percent of the county's adult population was considered either "overweight" or "obese" in 2016.
7.5 percent of our population is coping with diabetes.
Heart disease (19 percent) is the second-leading cause of death in the county, and many in our community struggle with high blood pressure.
Here's the good news: Many of these health challenges are preventable and can be reversed. George Fox University's Health and Wellness Week is a tangible way to assist community members in their pursuit of healthy living. Let's see if we can make a positive change in the health and wellness of Newberg.
For more information on the event, contact Tyler Cuddeford at tcuddeford@georgefox.edu.


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World Technology
Sudden accelerations in Tesla cars were user error: US govt
San Francisco, Jan 9 (IANS) A year-long review of Tesla cars in the US has concluded that there is not enough evidence to open a full investigation into claims that some Tesla vehicles were accelerating without warning the users.
The National Highway Traffic Safety Administration (NHTSA) said in a statement on Friday that "pedal misapplication" at the end of drivers was the actual cause of the problem.
NHTSA received 246 complaints about this "sudden unintended acceleration" phenomenon, reports The Verge.
"There is no evidence of any fault in the accelerator pedal assemblies, motor control systems, or brake systems that has contributed to any of the cited incidents," the agency said.
"There is no evidence of a design factor contributing to increased likelihood of pedal misapplication. The theory provided of a potential electronic cause of SUA in the subject vehicles is based upon inaccurate assumptions about system design and log data."
Tesla has settled most of a purported class action lawsuit in 2018 over the acceleration issue.
The review was opened in January 2020 in response to a petition by Brian Sparks, a Tesla investor.
"I believe Tesla vehicles have a structural flaw which puts their drivers and the public at risk. I further believe Tesla must know of this flaw and be unresponsive to it," he wrote in December 2019.
Tesla responded to the review with a blog post that claimed there was no merit to the idea
"We investigate every single incident where the driver alleges to us that their vehicle accelerated contrary to their input, and in every case where we had the vehicle's data, we confirmed that the car operated as designed," the company emphasised.
Electric Vehicle (EV) maker Tesla is under scrutiny over battery and security issues after at least two dozen complaints were filed with the NHTSA.
Tesla in November last year recalled over 9,500 Model X and Y SUVs built in 2015 and 2016.
Tesla issued the recall with NHTSA for 9,136 Model X SUVs built in 2015 and 2016 over pieces of the body that can detach while driving due to a lack of primer.
Tesla also issued a recall for 437 Model Y SUVs over a potentially loose bolt that could result in the upper control arm separating from the steering knuckle.
Previous articleLG unveils upgraded smart TV platform with new voice controls
Next articleBlessed to be first Keralite to hit century in ODI: CP Rizwan
Virgin Orbit's rocket deploys 10 NASA payloads via air launch
Apple planning a podcast subscription service: Report
Beijing sees robust growth in animation, mobile game industries


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Learn More About Administrative Law in Siloam, North Carolina
Siloam is an unincorporated community in southeastern Surry County, North Carolina, United States. The Yadkin River makes up the community's southern border, and the Ararat River flows between it and the community of Shoals to the east. It is a Piedmont Triad community. The population of the ZIP Code Tabulation Area (ZCTA) for Siloam's ZIP code (27047) was 1,233 at the 2000 census.
Administrative Law Lawyers In Siloam North Carolina
What is administrative law?
Administrative Law involves compliance with and challenges to rules, regulations, and orders of local, state, and federal government departments. Administrative law attorneys may represent clients before agencies like the workers compensation appeals boards, school board disciplinary hearings and federal agencies like the Federal Communications Commission. Administrative attorneys help negotiate the bureaucracy when interacting with the government to do things as varied as receiving a license or permit or preparing and presenting a defense to disciplinary or enforcement actions.
Answers to administrative law issues in North Carolina
Administrative law is law made by or about the executive branch agencies, departments, the President (at the federal...
What can be done to report tax fraud to the IRS?
The Tax Relief and Health Care Act of 2006 made significant changes to the Informants Reward Program under the False...
Federal court opinions concerning administrative law in North Carolina
307 US 174 United States v. Miller
790 F2d 694 Circle Dairy Inc v. Ao Smith Harvestore Products Inc
908 F2d 595 State of Oklahoma v. Environmental Protection Agency
972 F2d 222 Woodline Motor Freight Inc v. National Labor Relations Board
222 F3d 788 Duane Choate Patsy Sue Madewell Estate of Clinton Keith Madewell v. Champion Home Builders Company Heritage Mobile Homes Inc
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Learn the Law


In the most dramatic preview in Bachelor history, ABC uses the music from the epic Once Upon a Time trailer and sets it to clips from the season finale!
OK! NEWS: BACHELOR BEN FLAJNIK ON COURTNEY ROBERTSON'S BEHAVIOR: "AFTER WATCHING, IT'S NOT OKAY"
The lone Bachelor, Ben Flajnik, has to make a choice between good, Lindzi Cox, or evil, Courtney Robertson, but what will he do?
"I'm unsure of how this is going to end," Ben teases in the preview clip.
We're pretty sure Courtney didn't use any potions or poison apples on Ben, but she sure did manipulate him in more ways than one throughout the season (skinny dipping anyone?).
On the other hand, Lindzi, the sweet horseback rider from Seattle, did nothing but cherish her time with winemaker Ben, even if it didn't involve a naked rendezvous in the Puerto Rican sea.
So, who will Ben choose — the pretty princess Lindzi or the evil queen Courtney (We know, we're having too much fun with this whole Once Upon a Time thing!).


MMUA annually publishes 11 editions (combining July and August) of The Resource newsletter. This full-color, tabloid newspaper promotes association activities and provides in-depth coverage of the people, issues and events that affect Minnesota's municipal utilities. The Resource is a significant member benefit and popular advertising vehicle for those doing business with the state's municipal utilities.


Damon portrays astronaut, Mark Watney who is on a manned mission to Mars when a fierce storm pummels their attempt leaving his crew with the assumption he didn't survive and is summarily left behind. Stranded and left for dead on a hostile planet, with only the most base of supplies, means Watney must dig deep within to survive and search for a way to signal back to Earth that he is alive. Back on Earth, NASA and a large team of scientists try to come up with a plan to bring him home, all the while his team pools every ounce of daring they possess to attempt a remarkable rescue mission. The film is full of everything that's great about being a part of the human race.
Joining Damon on this mission are Jessica Chastain, Kristen Wiig, Jeff Daniels, Kate Mara, Sean Bean and Chiwetel Ejiofor as part of a truly star-studded cast directed by the one and only Ridley Scott and based on the book of the same name by Andy Weir. Check out the first trailer and then hit theaters when it bows in November of this year.
This entry was posted on Sunday, June 14th, 2015 at 1:34 am	and is filed under Film, News. You can follow any responses to this entry through the RSS 2.0 feed. You can skip to the end and leave a response. Pinging is currently not allowed.
« Film Review: 'Heaven Knows What'!


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Q: Less compiler issue - Deprecated feature I am trying to compile a .Less file and when I run it in Chrome, I get this problem:

I have installed both the dotless and Web Compiler 2022+ extensions in my project. I did have a look at this thread Here but it wasn't clear to me as it is referring to SASS not Less.
I have right-clicked on the .less file and clicked on Web Compiler > Compile, which generated the my.css file and the my.min.css.
Reference to .less file:
<link rel="stylesheet" href="css/My.less" type="text/css">

I'm using Visual Studio Community 2022 version 17.4.4

redpajama_set_name: RedPajamaStackExchange


The Global Dry Toilet Association of Finland renewed its strategy during the years 2011 and 2012. The work was lead by the strategy group where a large number of the Association's stakeholders participated. The new strategy for the 2013-2017 period was accepted during the autumn meeting of November 2012. The main targets of the strategy are the extension and maintenance of funding; providing services for the members; strengthening of the operations and security prerequisites.
Achievement of ecologically, socially, economically and culturally sustainable sanitation and nutrient cycle everywhere. The Global Dry Toilet Association of Finland is the best known expert organisation promoting ecological sanitation and DT technology in the country.
Mission The mission of the Association is to provide information, education and advice on dry toilets and the nutrient cycle (DT technology). The Association operates both in Finland and abroad, and the two modes of activity support each other. Ecological sanitation and a closed nutrient cycle ensure accessibility to safe, clean water and food supplies especially in developing areas.
Human rights based approach (HRBA) – Every individual has an equal right to clean drinking water and appropriate sanitation.
Operations based on ecologically, economically, socially and culturally sustainable development – In all activities, the principles of sustainable development are respected.
Safety and respect towards the laws of nature – Nutrients return sagely and in an environmentally friendly way to the cycle of life.
Openness and cooperation – Transparency and fairness are important aspects of the Association's working culture. Cooperation and networks are resources for the Association.


One of the primary ways the School aims to advance learning, knowledge, practice and capacity in the fields of public health and health systems is through the continued and increasing strategic collaboration with our partners in health.
There are no ivory towers or disciplinary boundaries, just a determination to produce people, and research that solve big problems. In drafting the School's strategic plan, we consulted widely with partners health promotion, public health, and health care.
Our partners identified six grand challenges for us to incorporate into our research, training, and service: the prevention and management of chronic diseases; food and water safety, security and governance; health for aging populations; health care system reform and integration; reducing health inequalities; and mitigating the effects of the environment on health.
They also asked for closer alliances and timely access to world leading faculty and students.
Create practice centres where agencies can get timely help from experts, and our students can get experience (i) with complex analyses and analytics; (ii) conducting rigorous scientific and policy reviews; (iii) designing and conducting program and policy evaluations; (iv) devising and testing new health informatics technologies and visualization techniques; (v) designing effective health communication and education, and more.
Create joint practice chairs with external partners, scientists in residence, entrepreneurs in residence, visiting professorships, and professional exchanges/interchanges.
Involve more professional leaders in our curriculum and research projects.
Offer customized training and professional development for partners.
Establish or link to leading edge, multi-disciplinary research centres related to each of the grand challenges.
Develop working relationships with like-minded academic institutions on every continent.


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Q: Non-equivalent phrasings of Playfair's Axiom which are in use For example on ProofWiki Playfair's Axiom is given as

Exactly one straight line can be drawn through any point not on a given line parallel to the given straight line in a plane.

but for example Wikipedia give it as

In a plane, given a line and a point not on it, at most one line parallel to the given line can be drawn through the point.

but both are not equivalent, which an be seen for example the incidence geometry consisting of three points $P, Q, R$ and the lines $\{ P, Q \}, \{ Q, R \}$ and $\{ P, R \}$. It fullfils the last, but not the first. So what is the real parallel postulate, and as they are both not equivalent they can not be equivalent to all the other forms, for example that being parallel is transitive and so on?

A: Both axioms you wrote are equivalent if you use the whole set of Hilbert's absolute geometry axioms.
It can be proved that at least one parallel line can be drawn through a point not lying on the line from absolute geometry axioms without any equivalent of Euclid's fifth postulate.
Lemma. An exterior angle of a triangle is greater than interior angle not adjacent to it.
With this lemma you can prove that if alternate angles are equal then the lines are parallel.
To prove that you can draw a parallel line through a point you lay off an alternate angle (you can do this by one of the axioms)

A: The notion of equivalence depends on the theory and the logic.
The two versions of Playfair's postulate you are giving are not equivalent in absolute geometry (a geometry without any assumption about existence and uniqueness of parallels) but are equivalent in neutral geometry (a geometry where parallel always exist but are not necessarily unique).
In the context of Tarski's neutral geometry, and without any continuity axiom, the uniqueness of parallel can be shown to be equivalent to the transitivity of parallelism.


CKC registered puppies come with a two year health guarantee, PetSecure Insurance, Tatoo, Microchip, etc. We have Chocolate, Yellow and Black puppies available at various times throughout the year. We breed for donating for assistance dogs, but also have puppies for sale to approved homes.
Contact for more information or have a peek at our website-or better yet,come visit our kennel!


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Sappington-Concord Historical Society
Located in the South County area of St. Louis, Missouri, USA
Veterans and SCHS
History and Me
Daytime Presentations
SCHS at Friendship Village Sunset Hills
Cakeway Cupcake Prize
Kids and History
Meet-at-the-Site Tours
Archival Displays
Family Roots
Harster Paintings
SCHS Community
Father Dickson Cemetery
Thomas Sappington House
Sunset Hills Historical Society
St.Louis Regional Historical Societies
Sappington-Concord: A History
Hometown Heroes Book
Women and Race
St Louis 250
Sappington-Arban House
St. Louis Moment by Moment – Katie Moon – Nov 7, 2014
Will Rogers Talk at SCHS Oct 22, 2014
Summer 2014 Bus Tour
Lewis and Clark Night for Kids
Memorial Day Ceremony – 2014
St Louis History Bus Tour
Memorable Women of the South County Area
250 Years of St. Louis History
Dr John Oldani – St. Louis Folklore
The Changing Forms of Polite Behavior
Related Events in Area
US Grant Symposium
Directions to Event Venues
Directions to Crestview Senior Living
Oak Bend Library
Directions to Grant's View Library
Spirit Festival Directions
Directions to Lindbergh High School
Directions to Tesson Ferry Library
Directions to S-C Memorial Park
Directions to St. Lucas UCC
Directions to St. Johns Evangelical UCC
Directions to Friendship Village Sunset Hills
Key to Photo Bars
The Dig at Sappington House
The Dig in Photos (2016-2018)
The Student Experience and Sappington House Campus
Resources – Sappington House
Resources – General Archaeology
Fliers, Brochure, Registration
Archaeological Institute of America – StL
Dig Events and Announcements
The Dig 2019 as it Progresses
Youth Education Programs at Sappington House
Soldiers Memorial Grand Reopening Nov 3
Stephen Hanpeter / November 3, 2018
Explore St Louis article on Soldiers memorial
The grand reopening will begin with a 9 am concert honoring veterans, followed by a formal ceremony at 10 am. Brigadier General Jeannie M. Leavitt, a St. Louis native and the US Air Force's first female fighter pilot, will give the keynote address.
Discover the new exhibits and explore the revitalized Soldiers Memorial and Court of Honor after the ceremony. The first 5,000 visitors will receive commemorative pins.
Enjoy a special musical performance of All Is Calm: The Christmas Truce of 1914, performed by Mustard Seed Theatre. Experience the story of soldiers who defied their commanders with a night of peace on the battlefield. Performances will take place daily at 3pm and 7pm, and the exhibits will remain open until the show begins each evening. Reserve your tickets at mohistory.org/all-is-calm.
Start your day at the 3rd annual St. Patrick Center Veterans Day 5K, which raises awareness for veteran homelessness. Afterward, head to Soldiers Memorial at 10am for the 35th Annual Regional Veterans Day Observance, a ceremony honoring area veterans. Stick around for the 35th Annual Veterans Day Parade, which will begin at 12pm at Chestnut St. and Tucker Blvd. and pass by Soldiers Memorial.
The armistice that ended hostilities during World War I was signed on the 11th hour of the 11th day of the 11th month of 1918. To commemorate the centennial of this important moment, join representatives of the American Legion 11th and 12th District for their annual veterans ceremony and wreath laying, starting at 10:55am.
For additional activities taking place between November 3 and 12, please visit mohistory.org/soldiers-reopening.
http://mohistory.org/events/grand-reopening-celebration_1541253600
Help commemorate the grand reopening of the revitalized Soldiers Memorial Military Museum, beginning with a musical arrangement honoring veterans. A formal ceremony will follow, with remarks from veterans and civic leaders. After the ceremony, stay to explore the new exhibits and the renovated museum. This event is free and open to the public.
The first 5,000 visitors to Soldiers Memorial will receive commemorative pins. Additionally, the US Postal Service will conduct a stamp cancellation commemorating the grand reopening of Soldiers Memorial from 11am to 1pm.
Food trucks will be available from 8am to 2pm.
American Sign Language interpretation will be provided at this program.
9am: Concert
10am: Formal opening ceremony
11am: Soldiers Memorial opens to the public
http://mohistory.org/blog/go-south-to-sunny-germany/
https://www.stltoday.com/news/local/photos-the-soldiers-memorial-is-ready-to-reopen-three-years/collection_8d21918f-c2e1-5826-a1a1-ce19f39d3c28.html#15
https://www.stltoday.com/entertainment/arts-and-theatre/after-million-overhaul-soldiers-memorial-shines-for-its-grand-reopening/article_424b1266-e569-5163-b563-c18646cf7a19.html
https://www.stlouis-mo.gov/government/departments/public-service/Soldiers_Memorial/news/soilders-memorial-grand-reopening.cfm
https://www.timesnewspapers.com/westendword/multimedia/photo_galleries/soldiers-memorial-military-museum-grand-re-opening/collection_c1616ce8-dc6b-11e8-821c-eb4dcc280b75.html
https://explorestlouis.com/event/the-grand-reopening-of-soldiers-memorial/
The grand reopening will begin at 9 a.m. with a concert honoring veterans, followed by a flag raising. The formal ceremony, featuring remarks from veterans and civic leaders, will begin at 10 a.m. American Sign Language interpretation will be provided.
Soldiers Memorial will open to the public at 11 a.m., and the first 5,000 visitors will receive commemorative pins. Additionally, the US Postal Service will conduct a stamp cancellation commemorating the grand reopening of Soldiers Memorial from 11 a.m. to 1 p.m.
Food trucks will be available from 8 a.m. to 2 p.m. and there will be a flag lowering ceremony at 5 p.m.
https://www.riverfronttimes.com/stlouis/grand-reopening-of-the-soldiers-memorial-military-museum/Event?oid=26641902
November 3, 2018 in Related Events in Area.
Nick Fry on The Ohio and Mississippi Railroad Jan27 2020
Sunset Hill Historical Society 2020 event schedule
Route 66 Aficionado Phil Denton – October 28 2019
← History book reprint available for sale November 10
'Bells of Peace' for Armistice Centennial Nov 11, 11am →
Upcoming SCHS Events
History Talks at Friendship Village
Slideshow from Photos page
Like SCHS on Facebook!
Recent SCHS Posts
German Fest at Sunset Hills Community Center 2019
Sunset Country Club by Jim Healey
SCHS Annual Memorial Day Ceremony – 2019
Birds on the Bats at Sunset Hills Historical Society
Celebration by Dan O'Neill
Forest Park – Don Corrigan
Categories of Posts Select Category Annoucement (1) Announcement (7) General historical information (11) Issues of Concern (7) Local News (12) Member Information (44) Membership Sales (1) Memorial Park (4) Messages from the President (2) Moments of History (5) Of special interest to kids (5) Press Release (8) Related Events in Area (148) Grant's View Library (3) Sappington House and Barn Restaurant (36) Sunset Hills Historical Society (32) US Grant National Historic Site (6) Report from Site (3) SCHS Events (86) Annual SCHS Memorial Day Ceremony (9) Bus Tour (2) Daytime Presentation (9) General Meeting (16) Meet-at-the-Site Tour (8) SCHS at Crestview (1) SCHS at Friendship Village (15) SCHS in the News (2) SCHS Members in Action (1) SCHS Programs (13) Book Reading and Discussion (2) Cakeway to the West (1) Library Display Case (4) Program Background Information (4) SCHS Display (1) SCHS program background information (1) The dig at Sappington House (27) Uncategorized (5) Video (1)
Sappington-Concord Historical Society proudly serving the area of the Lindbergh Schools in South St. Louis County, Missouri, USA for 25 plus years.
Follow SCHS on Facebook at https://www.facebook.com/ SappingtonConcord HistoricalSociety
SCHS serving the greater community of the Lindbergh Schools.
The World War II Honor Roll at Sappington-Concord Memorial Park.


Will ISIS attack the 2018 Winter Olympics?
What makes Singapore stronger than Qatar & UAE?
Governments' hollow rhetoric on Pakistan's expected climate disaster?
Trump Putin meeting: what hurdles will they have to address?
Pak-China cooperation strong at OBOR summit: What is India missing?


Charlotte's defense has fared well against the run. The 49ers, who share both Old Dominion's record (2-3) and a three-game losing streak like the Monarchs, rank third in Conference USA, allowing an average of 144 yards. In fact, Charlotte is the league's No. 1-ranked defense, permitting an average of 333.8 yards a game.
The 49ers have moved the ball well on the ground, led by Phillips, whose average of 101 yards a game rushing ranks behind only Lawry and Louisiana Tech's Kenneth Dixon in the league. Charlotte's problem has been scoring.
The 49ers rank next-to-last in the conference, averaging 16.2 points. Charlotte was hurt by turnovers in losses to Middle Tennessee and Florida Atlantic, and the offense moved the ball well against Temple but couldn't score.
Charlotte's coach isn't pinning all of the blame on players' performances.
Lambert says bad weather – the Florida Atlantic and Temple games were played in downpours – and facing good defenses contributed to the woes.
"But everyone plays in bad weather, and we've got to overcome that," he says.
Old Dominion has faced the same problem. The Monarchs, coming off a bye week like Charlotte, are only slightly ahead of the 49ers in scoring offense (16.6 points a game). Both teams are troubled in the passing game. Charlotte ranks 12th of 13 Conference USA teams in passing yardage per game. Old Dominion is 13th.
Injury update: Lambert says most of the players who missed games recently are ready to go Saturday. That includes Matt Johnson (quarterback), Austin Duke and Corey Nesmith Jr. (wide receivers) and Jamal Covington (offensive line).
He says linemen Eugene German (shoulder) and Devon Johnson (Achilles) appear to be ready, but the 49ers won't know for sure for a few days.
Future game times: Three of the 49ers' remaining seven games have kickoff times listed as "TBA," but Charlotte officials say the Nov. 14 home contest against Texas-San Antonio probably will start at 2 p.m. There's still no final word on the Halloween home game against Marshall and the Nov. 22 contest at Kentucky. Television networks will have the final word on those kickoffs.
A former assistant football coach for the University of Colorado has been sentenced to 30 days in jail for assaulting his ex-girlfriend.


Cadastre-se agora e comece a mapear o seu ciclo.
Sign up to receive your free Moondala!
Moondala is a map to study the synchronicity between the Lunar Cycle and your Menstrual Cycle.
With this simple, but powerful tool full of ancient wisdom, you are going to be able to get to know yourself and the mysteries and powers of your Woman Being from a new and profound perspective.
Sign up with your email address to receive your free Moondala, Moon Calendar, and a guide with instructions to begin this journey of no return into your body and towards the sacred woman that inhabits you.


WHAT IS LANGUAGE FOR LEARNING?
Language for Learning is the oral language program that teaches children the language they need for achievement in the classroom. Studies have shown that children differ greatly in how fast they learn language due to the amount of everyday language experience the child has in the home and school. For children who lack this language experience, through language instruction is urgently needed to help them succeed in the classroom.
Why Do We Feel Comfortable With This Program?
-Carefully orchestrated lessons leave nothing to chance.
-Everything that is introduced is taught through demonstration, actions, or pictures.
-Everything that is taught is practiced in many contexts until students fully understand the concept and can express them clearly.
How Do Students Benefit From Language for Learning?
• Learn hundreds of basic language concepts and instructional words.
• Practice following and giving directions and answering questions.
• Use different sentence forms.
• Accumulate general information and knowledge of classroom workings.
Every Instructional activity presented is part of an overall sequence that leads to higher order thinking.


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Tropical leaf extracts may boost pre-diabetic health measures: Clinical trial
By Stephen DANIELLS
10-Apr-2013 - Last updated on 11-Apr-2013 at 14:31 GMT
Ficus deltoidea
Related tags: Nutrition, Diabetes mellitus, Blood sugar
Daily supplements containing extracts from Elaeis guineensis or Ficus deltoidea may benefit the health of people with pre-diabetes by improving blood sugar and lipid levels, say findings from a clinical trial.
Eight weeks of supplementation with leaf extracts from the botanicals were associated with improvements in blood glucose levels for Elaeis guineensis and blood lipid levels for Ficus deltoidea, according to findings published in Nutrition Journal.
African oil palm (Elaeis guineensis) is said to equal soybeans as a source of human vegetable oil consumption. The mistletoe fig (Ficus deltoidea) has traditionally been taken in Malaysia as tea.
Extracts from the leaves of both botanicals have been reported to be rich in phenolic compounds with potential hypoglycemic effects. The study was funded by Biotropics Malaysia, which also provided the extracts used in the study.
Interesting implications
Lead author Douglas Kalman PhD, RD, Director, Nutrition & Applied Clinical Trials at Miami Research Associates, told NutraIngredients-USA that the study's findings have "interesting implications".
"These botanicals have prior data for having pharmacologic and physiologic activity as related to blood sugar control," he explained. "Early pre-clinical work demonstrated an incretin effect. This study was the first human clinical trial in a population at risk for diabetes (meeting the definition of pre-diabetic).
"We were pleasantly surprised to observe an effect of the E Guineensis for glucose and insulin effects (lowering) as well as the F Deltoidea for reducing lipids. Hallmarks of metabolic syndrome include abnormal blood sugar control and elevated blood lipids.
"These two botanicals seemed to have interesting and clinically relevant effects for improving the health of pre-diabetics. Most certainly both botanical agents are deserving of further research," added Dr Kalman.
As many as 79 million American adults are pre-diabetic, with many of them classed as overweight or obese, according to estimates from the US Centers for Disease Control and Prevention (CDC). This puts them at three times higher risk for developing type-2 diabetes than normal weight people.
Study details
Dr Kalman and his co-workers recruited 30 otherwise healthy adults with pre-diabetes with an average age of 45.6 and an average BMI of 32.1 kg/m2. Participants were randomly assigned to one of three groups: The first two groups received 500 or 1,000 milligrams per day of E. guineensis leaf extract, respectively, while the third group received 1,000 mg or F. deltoidea leaf extract for eight weeks.
Results showed that E. guineensis was associated with decreases in fasting plasma glucose and insulin levels, insulin resistance, and increases in insulin sensitivity.
On the other hand, F. deltoidea leaf extract was associated with significant reductions in total and LDL cholesterol concentrations, but no changes in glycemia variables, said the researchers.
Dr Kalman and his co-workers reported that they did not observed any serious adverse events during the study.
Commenting on the observations, the researchers noted that E. guineensis is rich in catechins and polyphenols, and earlier studies had indicated an effect in lab animals with diabetes.
"This suggests a potential benefit for the pre-diabetic and diabetic states," they said.
The results for F. deltoidea, however, disagreed with earlier animal studies, which had indicated a glucose lowering effect.
"This study did, however, demonstrate a lipid lowering effect of great clinical interest," wrote Dr Kalman and his co-workers.
"The decreases in total cholesterol and LDL observed are of statistical and clinical significance and are worthy of further exploration."
Source: Nutrition Journal
2013, 12:36
"Efficacy and safety of Elaeis guineensis and Ficus deltoidea leaf extracts in adults with pre-diabetes"
Authors: D.S Kalman, H.I. Schwartz, S. Feldman, D.R. Krieger
Related topics: Nutrition, Supplements
Spirulina can better manage blood sugar in diabetes patients
Analysis of Dietary Supplements and Health Foods
Agilent Technologies | 18-Feb-2021 | Data Sheet
The vitamins A, C, D, E, B6, B12, folate, and the minerals selenium, zinc, copper, and iron, are essential for normal immune function. Dietary supplements...
Pycnogenol® Reduces Severity of Dry Mouth
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Amerks' Tuesday Practice; Meyer Returns
There is a new face on the ice today. That face stands about a full head above all the other players. Looks like the Amerks are making good with their promise to get us a guy who can plow through goons like Mirasty (Syracuse Crunch) with one fluid punch. This beast's name is Riley Emmerson. He stands at 6'8″ and weighs in at 248 lbs. He was the tallest player drafted in the 2005 entry draft.
He was assigned to the Florida Everblades this seaon by the Minnesota Wild.
Like posted yesterday, Curt Styres didn't just want a guy who can just drop the gloves. Any team that looked on the Amerks' bench during a game would have to notice Emmerson and bemore careful about the moves they make on the ice, knowing there is someone there who is going to protect his teammates.
Check a few of Riley's fights out in some YouTube videos.
The very first thing I got to see when I sat down in my seat to watch practice today was Stefan Meyer getting on the ice. It's pretty exciting to see him out there…like a missing puzzle piece returning to complete a picture. He is out doing a full practice. Hopefully this means he will be able to play this weekend. He is an important part of this team and I expect him to be wearing the other "A" when the time comes.
Tyler Plante and Chris Beckford-Tseu were out early getting some extra tips from Bob Janosz. They have been working hard all season, but that just hasn't been enough so far. Something needs to click and it needs to happen soon.
Benoit keeps telling the players it doesn't matter how tired they are. "If you are tired and you are going to dump the puck, you PLACE it, PLACE IT!"
Jason Garrison still has the greatest looking slapshot I have seen. He hits the net about 9/10's of the time and it is powerful.
Janis Sprukts was just at the white board after the coaches explained what they are going to be doing next. He was helping explain to his linemates (Matthias and Repik) where they need to be during the play they are doing.
Keaton Ellerby was slacking during the sprints at the end of practice. He wasn't going all the way to the lines and was almost beheaded by Benoit for it. He is now going to be the last person on the ice doing laps until he learns not to slack ever again. There was a lot of yelling and a lot of bad words for Ellerby when he was caught not doing the drill right.
Michael Duco got elbowed in the face and it knocked his neck sideways, but he is fine. We asked him what he had to say about Mirasty calling him a rat. He only had one thing to say about it, "He's a loser."
Ellerby looks like he wants to kill himself now. Rory Fitzpatrick even came out from the showers (in his towel) just to yell at Keaton for the slacking he did. Why Rory was taking a shower is a mystery to me.
Missing players again today were Jordan Henry and Karl Stewart. Karl Stewart is out not because of injury, but because is having problems with his Visa. Plante told us everything will be worked out in time for Friday's game.
Tyler also told our son to wish them luck in the next game because, "They need a win."
Tyler's right, this team needs to turn this bus around and hopefully with the (possible) return of Meyer and the acquisition of Emmerson, this weekend can be the point in the season where we look back and laugh at our 0-5 start.
Friday's home game against the Quad City Flames starts at 7:35pm. That is only the first game of yet another busy weekend for the Amerks.
On Saturday, the Amerks take the short drive down the 90 to face the Syracuse Crunch. I would tell as many fans as possible to get to this game. With Emmerson on the roster, there is sure to be a matchup with Jon Mirasty. If nothing else…that will be very good to see.
And then on Sunday, the Amerks go down to Hershey to face the Bears. This will be a game I will purchase on the AHL Live network. I love to watch the two of the oldest teams in the AHL faceoff against each other.
Tags Injury UpdateJanis SpruktsPracticeRiley EmmersonRochester AmericansStefan MeyerTransactions


Maybe bring a brolly, just in case.
Talks on welfare reform, flags, parades and the past continued through the night.
The grand secretary of the Orange Order has said the organisation has made a "massive effort" to ensure tomorrow's celebrations pass off peacefully.
The Sinn Féin leader was speaking in the wake of yesterday's negotiation walk-out by Unionist parties.
Eamon Gilmore scheduled the meeting with Haass when he spoke with him on Monday.
Eamon Gilmore also called for a 'renewed commitment' to the peace process.
They asked people in the streets of the capital what they thought.
Comments by Sinn Féin's Martin McGuinness in relation to some of the unionist influence over the Haass talks have angered the leader of the DUP.
Richard Haass left Belfast on Tuesday, but says the effort involved in coming back this weekend is justified.
Richard Haass has been asked to chair an all-party panel that will make recommendations on how to deal with the most divisive issues by the end of the year.
Recent violence on the streets of Belfast filled me with despair; we need to teach our children respect for each other's identity and traditions to avoid passing on the failures of the past, writes Peter Osborne.
Violent scenes and riots in recent months have led the Police Federation for Northern Ireland to suggest the ban.
Both the BBC and the Press Association report that the the councillor was arrested after apologising for her comments last night.
The Tánaiste said he believed most members of the Orange Order would not condone the violence or the burning of the Irish flag.
More than 4,000 PSNI officers backed by 630 reinforcements from Britain are on duty across Northern Ireland.
Almost 50 parades described as "sensitive" as PSNI calls up additional support.
Sinn Féin MLA Gerry Kelly says a PSNI jeep drove at him, leaving him holding on to the security grill of the vehicle for a "considerable distance". Another MLA was injured in the incident.
The Parades Commission has issued determinations for three additional parades passing Clifton Street in Belfast.
The incident occurred in the early hours of this morning in west Belfast.
Sure, the rain fell but we had a laugh, right?
There was no Macnas in those days.
Protestors today did not try to "parade unlawfully into the city centre" – a move welcomed by police authorities.
Jack Wilshere was an unused sub in the Gunners' 0-0 draw with Aston Villa but manager Arsene Wenger says it's nothing to worry about.
Here are the five things you need to know as you head out of the office this afternoon.
The Royal Black Institution, a Protestant fraternity, played music outside a Catholic church in spite of advice from the Parades Commission.
The PSNI has called for "anyone with influence" to help them bring an end to the renewed violence.
We've put together lists for Ireland's main cities from the Gardaí and AA Roadwatch.
Nine things you need to know by 9am: O'Bama comes home, the UN votes to clamp down on Libya, and an end in sight for Japan's nuclear fears?
A round-up of the best events taking place around Ireland this weekend to celebrate St Patrick's Day.
A TOTAL OF 15 people were injured in a hit-and-run incident in Belfast on the night of the 11 July, the Belfast High Court has heard. The court heard that accused, a 29-year-old man, accelerated his car after it was surrounded by a group of men shouting sectarian abuse in the Village area of the city. The court denied the man's application of bail to attend the birth of his child.
AN 11-YEAR-OLD BOY HAS BEEN charged in connection to the Ardoyne riots which began on 12 July, BBC Northern Ireland reports. The boy, who is due to appear in court later this month, has been charged with riotous assembly and possession of an offensive weapon. He cannot be named for legal reasons, and is due back in court on 29 September.
PSNI says costs will impact on police services in the area.


text:
Q: How would one address a female priest in the Anglican Community? How would one address a female priest in the Anglican Community?
What do you call a female priest in the Episcopal church?

A: It varies, depending on the priestess's and parishioners' personal preferences (believe it or not, no pun intended).
She may be referred to as "The Reverend Cassandra Jones," yet, when addressed directly, she could be:
Dear Mother Jones
or
Dear Cassandra
See for yourself!


Grammy-nominated singer Kelis, provided guests with a culinary experience of some of her top dishes at Ford's My City, 4 Ways culture festival.
She also participated in a Q&A panel where she discussed her love for healthy cooking.
Guests were able to enjoy the Ride & Drive experience in the latest lineup of Ford vehicles including Ford Mustang, F-150, Explorer and Fusion. Both Fusion and Explorer are equipped with SYNC 3 that now comes with Alexa allowing hands-free navigation to direct you to your favorite restaurant, museum, concert or an important business meeting.
The day was topped off by a soulful performance by Raheem Devaughn.
Ford's My City, 4 Ways culture festival is a guide to the perspectives of four young African-Americans on Washington D.C.'s social and cultural landscapes: Arsha Jones (Lifestyle Influencer); Hamilton Glass (Art Influencer); Black Alley Band (Music Influencer); Chef Resha (Food Influencer). The event also included a powerful entrepreneur panel discussion with The Budgetnista, Melissa Butler, Emory Jones and Arsha Jones; as well as featured art by D.C.'s own Hamilton Glass.


Going around the world and seeing new countries is an exciting way to expand your cultural understanding. Unfortunately, medical emergencies can happen and cost you a lot of money. In these instances, Medigap can help.
When a person travels overseas, they are at the mercy of their travel nation's medical care system. In most cases, countries have pretty reasonable and reliable healthcare systems. However, that isn't always the case. Some nations have better healthcare systems than others and may cause a person to get either sub-standard care or stuck with a huge bill.
The American Board of Medical Specialists typically has a variety of doctors and hospitals posted at U.S. embassies. The quality of these doctors and hospitals will vary, but they are generally high-quality and reliable. However, they may not accept most types of Medicare.
Generally speaking, Medicare will not pay for medical treatment outside of the United States. This includes all 50 states, the District of Columbia, Puerto Rico, the U.S. Virgin Islands, Guam, American Samoa, and the Northern Mariana Islands. Coverage will only kick in if you are in America and the foreign hospital is either the only one that can treat your or is closer than another hospital.
This situation is typically only in border states like Texas or Canada. In fact, if you are traveling through Canada between Alaska and another state, Medicare may pay for your coverage if you are closer to a Canadian hospital. Beyond these rare and rather specific moments, Medicare will not pay for your treatment.
Medigap health insurance is designed to fill in the gaps between what your Medicare won't pay. For example, Medigap policies C through N will offer some kind of travel emergency health care coverage for travel outside of the country. Each policy will pay about 80 percent of your cost of care. This coverage will manage only your first 60 days of the trip and require a $250 deductible.
In most instances, your plan will have a limit of $50,000 per its lifetime. However, this is a major benefit for those who are traveling overseas. Rather than worry about getting angry bills in the mail or having to pay excessive money for the rest of their life, they can manage the situation in a constructive and money-saving way.
So anybody who plans on traveling around the world for an extended period need to consider getting this kind of Medigap insurance coverage. It can make their travel more enjoyable and avoid serious concerns and anxiety. For more information, contact companies like Senior Care Insurance Services.


We consistently get asked many questions by our existing clients and moving companies in general regarding their blogs and search traffic in general. So we thought we would take a step backward and discuss some here.
If you think about it, there is one main purpose for your website – to get a prospective moving customer to call you, email you or fill out your "request a quote" form. When one of those 3 things, or events, is completed, your website and all the SEO that goes into it has succeeded.
This can't happen without search traffic. But traffic is really a vanity metric. It can be good for the ego, especially that of an SEO company. It is great to show a client that their traffic is increasing, this IS a good thing. But a blog is supposed to be a customer acquisition channel, not a traffic acquisition channel. So yes, we are saying, it's not about traffic, it's about the right traffic, and then more of that traffic.
We worked with a moving company client that had previously written one particular blog post on their site which accounted for over 20% of their search volume. But when we dug into the metrics, none of that traffic converted to a call, email or filling out a form. Yes, it was great for the ego – it DID increase traffic, but it had nothing to do with moving customers.
In SEO terms we know we have a good blog post when the keywords the post is optimized for have high "search intent". Ok, another new buzzword! What the heck! But if you think about it, this will make total sense. We rank keywords from the number 0 to 3, where 0 is a keyword query that has nothing to do with moving or the future need to move, and 3 is someone that is looking for a mover now. That is what we mean by search intent, what is the intended result of the searcher.
For example, if someone types the keyword query "planning a move to san diego", "moving to san diego" or "how to move to san diego" and your blog post comes up at the top of the page, you have a high chance of getting them to convert to a potential client. These keywords and the many synonyms around them are definitely "high intent" search queries. We want that traffic.
So we recently wrote a blog post for one of our clients 10 Things you must know before you move to San Diego to do just that.
This post holds the top position for "planning a move to san diego".
This blog post, although relatively new is already ranking in the top for many keywords related to "moving to San Diego". It also is getting a large and growing search volume from all over the U.S. Its power is only going to grow over time and you can certainly expect that some of those landing on it, will want to fill out one of the forms on the page.
In later posts, we are going to talk more about featured snippets. That is when you write a blog post that answers a search query question and Google rewards you with the answer.
So keep on blogging and make sure the keywords you are targeting have "high search intent" and you surely can't go wrong.


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Ward 6 Councilwoman Wanda Smith, born and raised in Clarksville, continues the traditions of a family that blazed a trail of African-American activism and achievement in our community.
Smith credits her mother, Virginia Martin Hatcher, for teaching her the principles of justice, equality and community engagement. Her father, Otis L. Martin Sr. -- one of the Clarksville Police Department's first Black officers -- taught her to be merciful and to treat everyone with kindness and respect.
"Mrs. Hatcher was regarded by many as the Harriett Tubman of Clarksville," Councilwoman Smith said. "She wanted equality. She helped all races. She believed that God created us all equal and we all deserve freedom and peace as one people."
Smith said her father, who served CPD from the late 1950s to the '70s, taught her about community service.
"They called him Big Otis, and he was recognized for his long service," Smith said. "He always taught us to treat people with kindness and respect, and that you never mistreat people just because you have power. He would give people a second chance and help them if they were in trouble."
Smith, who grew up among five sisters and a brother, graduated from Clarksville High School, where she starred on the girls basketball team. Her parents owned and operated Virginia's Cafe, a soul food restaurant, where she developed her work ethic as she supervised, cooked, and waited on guests.
She also was the child who was drawn into her mother's quest for racial equality.
"I marched with her as a young girl. I was the one who worked with her in the NAACP and CORR (the Commission on Religion and Racism). I was her assistant, and her writer," Smith recalls.
Mrs. Hatcher was always ready to jump into local struggles for justice. As president of the NAACP branch in the 1970s, she investigated why Black officers weren't given police cars. Citing provisions in Title VI of the Civil Rights Act, she marched on, and soon, Black officers were driving police cruisers and patrolling the streets in the same manner as their white colleagues.
Later, she took up the cause of improving living conditions and treatment of inmates in the Montgomery County Jail. She fought for more equitable treatment of Black employees at Austin Peay State University, and she took on the Clarksville-Montgomery County School System over alleged mistreatment of a student from an activist family.
Mrs. Hatcher died in September 2017 and Otis Martin died in 1976, when Smith was 16.
Along the way, Smith accepted her call to become a minister -- first showing an early prophetic gift as she preached her first sermon at age 8 to her sisters at a homemade pulpit. She served on the ministerial staff at Cathedral of Praise in Nashville, and assistant to the president of Cathedral of Praise College. She also served as chaplain at the Montgomery County Jail, and has authored several religious books and papers, including The Kingdom Builder and The Baptist Leader, published by R.H. Boyd Publishing.
She's gone on to earn a bachelor's degree at American Baptist College in Nashville, a master of Theological Studies at Vanderbilt University, and a Doctor of Ministry degree from United Theological Seminary in Dayton, Ohio. She currently is working on a master's in Criminal Justice.
Throughout her work and ministry, Councilwoman Smith has remained committed to the local struggle for civil rights, racial equality and justice. For example, she was secretary of the Voter's Council, which registered hundreds of voters. She also led community efforts to name the Martin Luther King Jr. Parkway and to protect the Red River District. She was the keynote speaker at the 2008 Fort Campbell Black History Month program, and honored by the post's command.
In 2014 Smith was elected to represent Ward 6 on the Clarksville City Council. She was re-elected in 2018 to a second four-year term. She has been a strong advocate for her ward and diversifying the City's governance and workforce. She counts her advocacy to clean up and redevelop Ward 6, especially the old Frosty Morn plant, as one of her Council success stories.
⇐Previous Many City facilities to reopen MondayNext⇒ State seeks input on transportation access


Washington, Sep 4 (Prensa Latina) The International Committee for the Release of the Five Cuban Antiterrorist Fighters convicted in the United States, called today friends and solidarity groups to multiply yellow ribbons, a symbol of hope for the return of these men to their homeland.During the actions to be carried out from September 5 to October 6, especially those on September 12, the day marking the 15th anniversary of the detention of the Cuban Five.
Havana, May 7 (Prensa Latina) The return to Cuba of the four anti-terrorist fighters who remain imprisoned in the United States is a priority for Rene Gonzalez, who started the procedures to renounce his U.S. citizenship yesterday in this capital. "Until they all are here we must continue fighting (…) They will resist, they will not yield," Rene told the reporters after beginning the procedures to renounce his citizenship at the U.S. Interests Section in Havana, accompanied by his lawyer Philip Horowitz.
Havana, Apr 26 (Prensa Latina) René Gonzalez, one of the five Cuban anti-terrorist fighters unjustly convicted in the United States, is in this capital on a private and family visit, national media reported today. René is being held on U.S. soil for three years of supervised release, despite having served his sentence, and following the death of his father, Candido Gonzalez, he asked for permission to the Court for the Southern District of Florida to be with his family.


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text:
Most kids now eligible for COVID-19 vaccine
WUWF | By Dave Dunwoody
Jae C. Hong
Six-year-old Eric Aviles receives the Pfizer COVID-19 vaccine from pharmacist Sylvia Uong at a pediatric vaccine clinic for children ages 5 to 11 set up at Willard Intermediate School in Santa Ana, Calif., Tuesday, Nov. 9, 2021.
After months of testing and speculation, children ages 5-11 can begin getting vaccinated for COVID-19 this week.
"We had vaccine almost year ago now for adults; and we have taken the time to get this right for our children," said CDC Director Dr. Rochelle Walensky, appearing on the "CBS Morning Show."
Federal health officials gave final approval last week to use the Pfizer-BioNTech vaccine for about 28 million kids in that age group.
"This is a child-size dose, it's one-third the [adult] dose; we've done the clinical trials in children between the age of 5-11," said Walensky. "We've done the incredible due-diligence to take the time to get it right."
Almost 2 million children ages 5-11 have been infected with COVID-19 or with the Delta variant, according to the Centers for Disease Control and Prevention. More than 8,300 have been hospitalized, with 94 deaths. The latter places the virus among the top 10 causes of death in that age group.
"Young people are not just smaller, older people, and with all vaccines we have different doses," Walensky said. "So, what they've done in these clinical trials is to look at dose de-escalation — to make sure the younger children are getting the right dose — both to balance the effectiveness and to make sure there were no side effects. And they absolutely hit that 'sweet spot' with this dose."
Federal health officials gave final approval on Nov. 2 for using the Pfizer-BioNTech vaccine, for about 28 million kids. The protocol is two shots, given 21 days apart.
The Florida Department of Health in Escambia County offers that, and continues to offer COVID-19 vaccines to adults, in its clinic at West Fairfield Drive in Pensacola.
"We are so excited to be able to provide vaccines for children 5-11 years old now in our clinic; and we'll be offering those vaccines from 8 a.m. until 3:30 p.m. Monday through Friday," said Dr. Vanessa Philips at Escambia DOH.
She adds that, contrary to some rumors, this is not a watered-down version of the adult vaccine.
"Pediatric doses are a little smaller than the adult doses, to accommodate for evenly," said Phillips. "I hope and pray [for] a large turnout on Monday, but no matter the turnout, we are ready. The clinics are operational, and we have enough staff to accommodate."
Although the patients change — from adults to children in this instance — the Health Department's message remains the same.
"The vaccines are here; they're safe, and they're effective for every age group. This is the way we're going to get back to normal," Phillips said. "Right now, I'm not sure when we're expecting more, but we have more than enough doses to accommodate a full rush for the next couple of months."
And Phillips says the main protocol they continue to practice — now with the new eligibility— is also unchanged.
"I think our key measures were availability— we wanted to make sure that we removed any gaps that were there — or lessen those gaps where possible and provide an access," Phillips said. "And that's what we pride ourselves on. We are making sure that vaccine is available to whoever needs, whenever they want it."
Questions can be directed to FDOH-Escambia's COVID-19 phone line at 850-595-6500, option 6.
Dave Dunwoody
Dave came to WUWF in September, 2002, after 14 years as News Director at the Alabama Radio Network in Montgomery, Mobile and Birmingham and a total of 27 years in commercial radio. He's also served as Alabama Bureau Chief for United Press International, and a stringer for the Birmingham Post-Herald.
See stories by Dave Dunwoody


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Corvite é uma povoação portuguesa do município de Guimarães com 1,85 km² de área e 883 habitantes (2011). Densidade: 477,3 hab/km².

Foi sede de uma freguesia criada em 1 de Janeiro de 2004 por desanexação de territórios da freguesia de Ponte e extinta em 2013, no âmbito de uma reforma administrativa nacional, para, em conjunto com Santo Tirso de Prazins, formar uma nova freguesia denominada União das Freguesias de Prazins Santo Tirso e Corvite com a sede em Prazins Santo Tirso.

Património
 Igreja Velha de Santa Maria de Corvite

População

Freguesia criada pela Lei nº 62/2003, de 22 de Agosto, com lugares desanexados da freguesia de Junta de Ponte . Em 2011 registava 883 habitantes.

Antigas freguesias de Guimarães


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