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"Congo Jazz" & "The Booze Hangs High"
"Congo Jazz" (short) & "The Booze Hangs High" (short), 1930. Bosko dances with jungle animals, and Bosko dances with barnyard animals.
Directed by Hugh Harman & Rudolf Ising. Starring Johnny Murray.
Concept: 1/4 (Bad)
Story: 0/4 (Terrible)
Dialog: 2/4 (Indifferent)
Special effects/design: 3/4 (Good) for "Congo" / 2/4 (Indifferent) for "Booze"
Subjective Rating: 7/10 (Good, 3/4). These cartoons are kind of wonderful. They've changed Bosko's voice to a Mickey Mouse type thing, which means I wouldn't recognize him as a racial stereotype if I hadn't seen his earlier incarnation. And the lack of a plot doesn't hurt quite as much as it did in "Sinkin' in the Bathtub," maybe because they don't even bother to pretend there might be a story. It's just a lot of whimsical, old-timey dancin'. And, occasionally, something really bizarre happens.
Objective Rating (Average): 2.0/4 (Indifferent) / 1.9/4 (Eh)
Posted by Daniel at 11:15 AM No comments:
The Aristocats, 1970. A rich woman's butler tries to get rid of her cats.
Directed by Wolfgang Reitherman. Written by Larry Clemmons, Vance Gerry, Ken Anderson, Frank Thomas, Eric Cleworth, Julius Svendsen & Ralph Wright, based on a story by Tom McGowan & Tom Rowe. Starring Phil Harris & Eva Gabor.
Cinematography: 3/4 (Good)
Subjective Rating: 7/10 (Good, 3/4). There's no moral to be learned, no catchy songs, no marketable goofy sidekick, a villain that could not be less threatening, and rarely any action that involves the protagonist. So I can see why this film tends to be one of the less classic of the Disney "classics." But personally, I'd say every one of those points is a plus. Add to that some excellent animation, an adorable mouse played by Sterling Holloway, one or two very funny sequences, a fun score, and cat characters that are perfectly cat-like and believable, and I'd say this is probably one of the top ten Disney cartoons.
"Bath Day"
"Bath Day" (short), 1946. Minnie Mouse's cat is teased by alley cats.
Directed by Charles A. Nichols. Written by Eric Gurney. Starring Ruth Clifford & Clarence Nash.
Subjective Rating: 5/10 (Indifferent, 2/4). Fairly humorless, and not half as cute as it seems to think it is.
"Sinkin' in the Bathtub"
"Sinkin' in the Bathtub" (short), 1930. Bosko goes for a drive to visit his girlfriend.
Directed by Hugh Harman & Rudolf Ising. Written by Friz Freleng. Starring Carman Maxwell & Rochelle Hudson.
Subjective Rating: 7/10 (Good, 3/4). Absolutely delightful, for about two minutes. The lack of any kind of story starts to hurt more and more as it goes on.
Buffy the Vampire Slayer (the movie)
Buffy the Vampire Slayer, 1992. A shallow valley girl becomes a vampire hunter.
Directed by Fran Rubel Kuzui. Written by Joss Whedon. Starring Kristy Swanson, Donald Sutherland & Luke Perry.
Concept: 3/4 (Good)
Cinematography: 0/4 (Terrible)
Special effects/design: 0/4 (Terrible)
Acting: 1/4 (Bad)
Subjective Rating: 6/10 (Okay, 2/4). Surprisingly entertaining - sometimes because it's campy fun, more often because it's amusingly awful.
Objective Rating (Average): 1.4/4 (Bad)
Match Point, 2005. A man marries into wealth and has an affair.
Written & directed by Woody Allen. Starring Jonathan Rhys Meyers, Emily Mortimer & Scarlett Johansson.
Pacing: 1/4 (Bad)
Subjective Rating: 4/10 (Eh, 2/4). The first two thirds of the movie is a cliched melodrama with no character to empathize with. After that, it spontaneously turns into a suspense film. That second part is interesting, but not exceptional and certainly not worth watching the first part of the movie.
Objective Rating (Average): 2.0/4 (Indifferent)
Posted by Daniel at 12:37 PM No comments:
"Bosko the Talk-Ink Kid"
"Bosko the Talk-Ink Kid" (short), 1929 (unreleased). An animator asks his drawing to entertain the audience.
Directed by Hugh Harman & Rudolf Ising. Starring Ising & Carman Maxwell.
Acting: 2/4 (Indifferent). Bosko's very expressive. Rudolf Ising, not so much.
Subjective Rating: 6/10 (Okay, 2/4). It's very difficult to evaluate this. One the one hand, it's whimsical and fun and made me laugh. On the other hand, it's racist. The racism has nothing to do with what that cartoon is doing - the character just incidentally happens to be a caricature. So you can try to compartmentalize that and enjoy what would otherwise be a great cartoon. But it's still there.
Posted by Daniel at 2:50 PM No comments:
Amour, 2012. A man cares for his dying wife.
Written & directed by Michael Haneke. Starring Jean-Louis Trintignant & Emmanuelle Riva.
Pacing: 0/4 (Terrible). It's not just slow, it's static. Most scenes contain about ten seconds of action and several minutes of waiting for the next scene.
Acting: 4/4 (Great)
Subjective Rating: 3/10 (Bad, 1/4). I really expected to like this. I love movies about these sorts of characters. But this one didn't do a single thing for me. I was unaffected and bored silly.
Doctor Who #8: The Reign of Terror
Doctor Who: The Reign of Terror, 1964 (the last story of eight from season one). The French Revolutionary government imprisons the Doctor's friends.
Directed by Henric Hirsch (5 episodes) & John Gorrie (1). Written by Dennis Spooner. Starring William Hartnell, William Russell, Jacqueline Hill & Carole Ann Ford.
Pacing: 0/4 (Terrible)
Cinematography: 0/4 (Terrible). The two animated episodes are nearly unwatchable.
Special effects/design: 1/4 (Bad)
Subjective Rating: 3/10 (Bad, 1/4). Extremely boring.
Labels: doctor who 1963
"Dug's Special Mission"
"Dug's Special Mission" (short), 2009. Dogs are mean to another dog.
Directed by Ronaldo Del Carmen. Written by Del Carmen & Bob Peterson. Starring Peterson.
Subjective Rating: 4/10 (Eh, 2/4). It feels very forced - probably because it is. It clearly has no reason for existing other than as a selling point for the Up DVD.
"Burn-E"
"Burn-E" (short), 2008. A robot has bad luck repairing a spaceship.
Directed by Angus MacLane. Written by MacLane, Andrew Stanton & Derek Thompson.
Subjective Rating: 6/10 (Okay, 2/4). Cute. It can't stand on its own without Wall-E, although they could have made it do so - and ended up with a much better cartoon - if they'd wanted to.
Objective Rating (Average): 2.7/4 (Good)
from my 100 Popular Movies Marathon, part 2 of 100
The Magnificent Seven, 1960. Gunslingers defend a village from bandits.
Directed by John Sturges. Written by William Roberts. Starring Yul Brynner, Eli Wallach, Steve McQueen & Horst Buchholz.
Story: 3/4 (Good)
Special effects/design: 2/4 (Indifferent). It really bothered me that all of the gun sound effects are identical. I could barely pay attention to the final shoot-out, it's so distracting.
Subjective Rating: 7/10 (Good, 3/4). It's no Seven Samurai, but it's still a pretty darn good movie.
Labels: popular movies
Papillon, 1973. A man tries to escape from a French prison colony.
Directed by Franklin J. Schaffner. Written by Dalton Trumbo & Lorenzo Semple Jr., based on a book by Henri Charrière. Starring Steve McQueen & Dustin Hoffman.
Special effects/design: 2/4 (Indifferent).
Acting: 2/4 (Indifferent). McQueen actually does some great acting in the solitary confinement scenes. And some remarkably bad acting in the island scenes. I felt embarrassed for the movie.
Subjective Rating: 5/10 (Indifferent, 2/4). Very uneven. Most of it is pretty good, but then large chunks of it, especially toward the end, are terrible.
The Many Adventures of Winnie the Pooh, 1977. A compilation of Winnie the Pooh shorts.
Directed by Wolfgang Reitherman & John Lounsbery. Written by Winston Hibler, Larry Clemmons, Ralph Wright, Vance Gerry, Xavier Atencio, Ken Anderson, Julius Svendsen, Ted Berman & Eric Cleworth, based on books by A.A. Milne. Starring Sterling Holloway.
Characters: 4/4 (Great)
Dialog: 4/4 (Great)
Pacing: 2/4 (Indifferent). Too bad they don't let you watch them as shorts. It's like watching three movies in a row without a chance to take a breath in the middle - because that's exactly what it is.
Subjective Rating: 9/10 (One of my favorites, 4/4 5/4). "Blustery Day" and "Tigger Too" aren't as crazy amazaballs wonderful as "Honey Tree," which is a shame, but they're still delightful. "Honey Tree," though - that is one of the best things ever made.
Objective Rating (Average): 3.6/4 3.7/4 (Great)
VSM: 100 Very Popular Movies We Need To Watch
It's been a busy summer here - not much time to watch stuff, so not much blogging happening. But we are back at it now, with a massive project to draw us in. These are the most popular* features that we've either never seen, or haven't watched in the last five years or so.
* "popular" according to an arbitrary algorithm that takes into account IMDb scores, and number of IMDb votes weighted for the age of the movie
Very Slow Marathon #16: 100 Very Popular Movies We Need To Watch
1. Papillon, 1973
2. The Magnificent Seven, 1960
3. The Ten Commandments, 1956
4. The Matrix Reloaded, 2003
5. Speed, 1994
6. Die Hard: With a Vengeance, 1995
7. The Fifth Element, 1997
8. Taken, 2008
9. Lolita, 1962
10. The Butterfly Effect, 2004
11. RoboCop, 1987
12. Total Recall, 1990
13. Minority Report, 2002
14. Gattaca, 1997
15. Training Day, 2001
16. Dead Poets Society, 1989
17. Back to the Future Part II, 1989
18. The Rock, 1996
19. Scent of a Woman, 1992
20. Back to the Future Part III, 1990
21. The Invisible Man, 1933
22. Mr. Deeds Goes to Town, 1936
23. The Birth of a Nation, 1915
24. Freaks, 1932
25. Intolerance, 1916
26. Star Wars: The Phantom Menace, 1999
27. Star Wars: Revenge of the Sith, 2005
28. Stagecoach, 1939
29. The Breakfast Club, 1985
30. 300, 2006
31. Ferris Bueller's Day Off, 1986
32. Dirty Harry, 1971
33. The Untouchables, 1987
34. Cat on a Hot Tin Roof, 1958
35. The Phantom of the Opera, 1925
36. Blazing Saddles, 1974
37. The Last Laugh, 1924
38. To Have and Have Not, 1944
39. West Side Story, 1961
40. The Evil Dead, 1981
41. A Few Good Men, 1992
42. Night and Fog, 1955
43. Cast Away, 2000
44. X-Men, 2000
45. White Heat, 1949
46. This Is Spinal Tap, 1984
47. X-Men 2, 2003
48. Grease, 1978
49. Sullivan's Travels, 1941
50. Interview with the Vampire, 1994
51. Airplane!, 1980
52. The Fugitive, 1993
53. Breathless, 1960
54. American Psycho, 2000
55. Men in Black, 1997
56. The Rules of the Game, 1939
57. Home Alone, 1990
58. The Game, 1997
59. Mutiny on the Bounty, 1935
60. Clerks, 1994
61. As Good as It Gets, 1997
62. True Romance, 1993
63. Donnie Brasco, 1997
64. The Goonies, 1985
65. Lost in Translation, 2003
- 28 Days Later, 2002
- Aladdin, 1992
- Almost Famous, 2000
- Angels with Dirty Faces, 1938
- Black Hawk Down, 2001
- Blue Velvet, 1986
- Boondock Saints, 1999
- Carlito's Way, 1993
- Catch Me if You Can, 2002
- Collateral, 2004
- Dumb & Dumber, 1994
- Face/Off, 1997
- From Here to Eternity, 1953
- Gangs of New York, 2002
- The Girl with the Dragon Tattoo, 2011
- The Godfather Part III, 1990
- I Am Legend, 2007
- Ice Age, 2002
- The Intouchables, 2011
- Key Largo, 1948
- The Last Samurai, 2003
- Lethal Weapon, 1987
- Love Actually, 2003
- The Notebook, 2004
- Office Space, 1999
- The Others, 2001
- Pirates of the Caribbean: Dead Man's Chest, 2006
- The Pursuit of Happyness, 2006
- Rio Bravo, 1959
- Saw, 2004
- Shrek, 2001
- Superbad, 2007
- To Be or Not to Be, 1942
- Tokyo Story, 1953
- Transformers, 2007
Life of Pi, 2012. A boy and a tiger in a lifeboat.
Directed by Ang Lee. Written by David Magee, based on a book by Yann Martel. Starring Suraj Sharma & Irrfan Khan.
Subjective Rating: 7/10 (Good, 3/4). Maybe it's hurt by watching it on a two-dimensional small screen, but I don't understand all the fuss about the visuals. Yeah, they did a lot of stuff that would have been unfilmable five or ten years ago, but it still just looks like cartoons to me. This is nitpicking, though; it's a very good movie.
Posted by Daniel at 9:57 AM No comments:
The World's End, 2013. A man tries to relive his youth with a pub crawl, during an invasion of body snatchers.
Directed by Edgar Wright. Written by Simon Pegg & Wright. Starring Pegg.
Concept: 2/4 (Indifferent). Basically just repeats stuff from Shawn of the Dead.
Subjective Rating: 7/10 (Good, 3/4). Very entertaining, but not particularly memorable.


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01 April 2019 What is the optimal dose of clopidogrel in paediatric patients?
What is the optimal dose of clopidogrel in paediatric patients?
¿Cuál es la dosis óptima de clopidogrel en pacientes pediátricos?
Cristina Mondelo Garcíaa,
cristina.mondelo.garcia@sergas.es
, Cristina Martínez Rocaa, Fernando Rueda Núñezb, María Isabel Martín Herranza
a Departamento de Farmacia, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), A Coruña, Spain
b Departamento de Cardiología Pediátrica, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), A Coruña, Spain
Table 1. Patients, sex (M=male, F=female), age, diagnosis, treatment (clopidogrel, ASA=acetylsalicylic acid, ACO=anticoagulant therapy, PPI=proton pump inhibitor).
The aim of this study was to collect retrospective data on the prescription of clopidogrel, describe the conditions of its use in the paediatric population of a tertiary referral hospital, and evaluate its use based on the current scientific evidence.
We conducted a retrospective, observational and descriptive study between March 2010 and March 2017. We included all patients under the age of 18 who were discharged from our hospital for home treatment with clopidogrel within the study period. We collected data on the following: demographic data, diagnosis, indication for clopidogrel, start and end date of treatment, presence or absence of concomitant treatment with acetylsalicylic acid or other antiplatelet or anticoagulant drugs, concomitant treatment with proton pump inhibitors, effectiveness, and adverse effects.
The study included a total of 11 patients (45% male). The mean age was 3.1 years (range, 1 month to 8 years). The prescribed dose of clopidogrel was 0.2mg/kg/day in all patients, and 10/11 patients received concomitant treatment with acetylsalicylic acid with the purpose of optimising antiplatelet therapy. None of the children received concomitant treatment with anticoagulants, and only one of them received treatment with a proton pump inhibitor. We did not find evidence of haemorrhagic complications or other adverse effects associated with clopidogrel.
Based on our experience, a clopidogrel dose of 0.2mg/kg/day is a safe and effective treatment, regardless of the patient's age. The good tolerance observed in our study could be related to the adjustment of the optimal dose with the aim of achieving antiplatelet aggregation without increasing the risk of adverse effects.
Antiplatelet
Cardiac surgical procedures
El objetivo de este estudio fue recopilar datos retrospectivos sobre la prescripción de clopidogrel y describir las condiciones de uso en la población pediátrica de un hospital de referencia de nivel terciario y evaluarlas con base en la evidencia disponible.
Pacientes y métodos
Estudio observacional, descriptivo y retrospectivo realizado entre marzo de 2010 y marzo de 2017. Los criterios de inclusión fueron: 100% de los pacientes menores de 18 años que fueron dados de alta de nuestro hospital con clopidogrel como tratamiento domiciliario en el período de estudio. Se recogieron los siguientes datos: datos demográficos, diagnóstico, indicación de clopidogrel, fecha de inicio y de finalización del tratamiento, presencia o ausencia de tratamiento concomitante con ácido acetilsalicílico u otros antiagregantes plaquetarios o anticoagulantes, tratamiento concomitante con inhibidores de la bomba de protones, efectividad y efectos adversos.
Un total de 11 pacientes se incluyeron en el estudio (45% hombres). La edad promedio fue de 3,1 años (rango: 1 mes-8 años). La dosis recomendada de clopidogrel fue de 0,2mg/kg/día en todos los individuos, recibiendo tratamiento concomitante con ácido acetilsalicílico 10/11 pacientes para optimizar la terapia antiplaquetaria. Ningún niño recibió tratamiento concomitante con anticoagulantes y solo uno de ellos recibió tratamiento con inhibidores de la bomba de protones. No se observaron trastornos hemorrágicos u otros efectos adversos asociados con clopidogrel.
Según nuestra experiencia, la dosis de clopidogrel de 0,2mg/kg/día demostró ser una estrategia segura y efectiva, independientemente de la edad del paciente. La buena tolerancia observada podría estar asociada con el ajuste de la dosis óptima para lograr la antiagregación plaquetaria sin aumentar el riesgo de efectos adversos.
Agentes antiagregantes
Procedimientos de cirugía cardíaca
Clopidogrel is a prodrug derived from thienopyridine. It is metabolised by CYP450 to its active metabolite, which irreversibly and selectively blocks the adenosine-diphosphate (ADP) bond to its P2Y12 platelet receptor and the subsequent activation of the ADP-mediated GPIIb–IIIa complex, thereby inhibiting platelet aggregation.1
As it is administered orally and does not require monitoring of its blood levels or its antiplatelet activity according to its summary of product characteristics, clopidogrel offers an attractive alternative for treatment of paediatric patients at risk of thrombotic events.2
The PICOLO clinical trial (2008) showed that in children aged 0–24 months, a dose of clopidogrel of 0.2mg/kg/day achieved a suitable inhibition of platelet function, comparable to the effect observed in adults with a dose of 75mg/day.3
Little information has been published to date on the use of clopidogrel in children over the age of 2 years, and the available literature is limited to case series where there were significant differences in the administered doses of clopidogrel (0.2–9mg/kg/day).2,5–8
The aim of this article was to describe our experience with the use of clopidogrel in paediatric patients and the conditions of its use in a tertiary level hospital that is a referral centre for heart surgery and paediatric heart disease, and to evaluate this use based on the current evidence.
We conducted a retrospective, observational and descriptive study was on the use of clopidogrel in paediatric patients. The study included every patient under the age of 18 years who were discharged from our hospital for home treatment with clopidogrel between March 2010 and March 2017.
We identified patients by searching the electronic prescription database and the register of off-label medication dispensed by our pharmacy department. We reviewed the electronic clinical records using the IANUS® (the institutional electronic health record database of the Galician Health Service) and the ICIP® (Philips) applications, collecting data on the following: demographic variables, diagnosis, indication for clopidogrel, start and end date of treatment, use or lack thereof of concomitant treatment with acetylsalicylic acid or other antiplatelet or anticoagulant drugs, use or lack thereof of concomitant treatment with proton pump inhibitors (PPIs), effectiveness, and adverse effects associated with treatment. We considered effectiveness adequate if there were no documented no arterial thrombotic or thromboembolic events. We did not find evidence of any haemorrhagic complications or other adverse effects associated with the use of clopidogrel.
We consulted the Uptodate® and Micromedex® databases to compare our experience with the current scientific evidence (April 2017).
We included a total of 11 patients in the study (Table 1), 5 male and 6 female, with a mean age of 3.1 years (range, 1 month to 8 years). All patients received an oral solution of clopidogrel 5mg/mL prepared by the hospital pharmacy. Every patient had some type of hemodynamically significant congenital heart disease. The indication for administering clopidogrel was the prevention of arterial thrombotic and thromboembolic events associated with cardiac surgery or catheter-based interventions. Treatment with clopidogrel was initiated after implantation of one or more stents in all patients, with the exception of one patient in whom it was indicated following distal aortic arch reconstruction with anastomosis and sectioning of the ductus.
Patients, sex (M=male, F=female), age, diagnosis, treatment (clopidogrel, ASA=acetylsalicylic acid, ACO=anticoagulant therapy, PPI=proton pump inhibitor).
PPIs
1 M 5 months Tetralogy of Fallot 0.20mg/kg/24h (68 days) YES NO NO
2 M 1 month Shone syndrome 0.18mg/kg/24h (139 days) NO NO NO
3 F 8 months Tetralogy of Fallot 0.2mg/kg/24h(30 days) YES NO NO
4 F 4 years Pulmonary stenosis 0.22mg/kg/24h (135 days) YES NO YES
5 M 7 years Pulmonary atresia 0.20mg/kg/24h (30 days) YES NO NO
6 F 2 months Tetralogy of Fallot 0.24mg/kg/24h (25 days) YES NO NO
7 M 1 month Congenital pulmonary valve disease 0.20mg/kg/24h (24 days) YES NO NO
8 F 8 years Tetralogy of Fallot 0.18mg/kg/24h (60 days) YES NO NO
9 F 6 years Complex congenital heart disease 0.21mg/kg/24h (60 days) YES NO NO
10 F 5 years Hypoplastic left heart syndrome 0.21mg/kg/24h (39 days) YES NO NO
11 M 3 years Pulmonary atresia 0.23mg/kg/24h (30 days) YES NO NO
The prescribed dose was 0.2mg/kg/day in all patients, with 10/11 patients receiving concomitant treatment with acetylsalicylic acid (mean dose, 4.8mg/kg/day; range, 3.6–5.8mg/kg/day) to optimise the antiplatelet therapy. None of the patients received concomitant treatment with anticoagulant agens, and only one patient received treatment with PPIs. The mean duration of antiplatelet therapy was 58 days; median duration: 39 days (range, 24–139 days). No arterial thrombotic or thromboembolic events were documented. There was no record of haemorrhagic complications or other adverse effects associated with the use of clopidogrel. The platelet count remained within normal range in all cases, and none of the patients died during the followup (30 days to 5 years, depending on the patient).
The literature describes two groups of patients that would receive different doses of clopidogrel based on their age: a first group that would include all patients under age 2 years (dose of 0.2mg/kg/24h), and a second group including all patients aged more than 2 years (dose of 1mg/kg/24h). In our hospital, the prescribed dose of clopidogrel was 0.2mg/kg/24h regardless of the age of the patient (6 patients in our study were more than 2 years old).
For a clinical practice to be considered adequate, it has to be validated based on objective data on its efficacy and safety. This validation process is based on clinical trials. The need to carry out specific research in the paediatric population stems from the differences in physiological and psychological development relative to adults, which could result in specific responses to treatment and different safety profiles. However, clinical research in paediatrics is hindered by the fact that children are considered a vulnerable group that requires special protection as well as the limited economic appeal of many paediatric clinical trials for the pharmaceutical industry, and off-label prescriptions amount to 30% to 90% of the total in this age group.9
The main problems caused by the lack of drugs specifically approved for children are the absence of suitable formulations for their correct administration and a lack of data regarding their optimal dose, specific toxicity and long-term safety. In the case of clopidogrel, the current literature recommends two dose ranges depending on whether the child is aged more or less than 24 months.
The dose for newborns and children up to age 2 years recommended in literature (0.2mg/kg/day) derives from two clinical trials (PICOLO and CLARINET) that included a total of 998 patients. The results of the PICOLO trial showed that a dose of 0.2mg/kg/day of clopidogrel in children aged 0–24 months achieved adequate inhibition of platelet function, comparable to that achieved in adults with a dose of 75mg/day (approximately 1mg/kg/day). In this study, 79% of the included children received acetylsalicylic acid as a concomitant treatment, and none experienced serious haemorrhagic events.3 The CLARINET trial included children under 93 days of age with cyanotic congenital heart disease and systemic-to-pulmonary artery shunts who were treated with 0.2mg/kg/day of clopidogrel added to conventional therapy, which included acetylsalicylic acid in 87.9% of the patients. The addition of clopidogrel to conventional treatment did not lead to an increase in efficacy and was associated with a 0.7% increase in the incidence of severe haemorrhage.4
The dose of clopidogrel suggested for children aged more than 2 years in the literature has been derived from several case reports, with significant differences in the administered doses, which have ranged from 0.2 to 9mg/kg/day.
Finkelstein et al. carried out a retrospective review of 15 patients (mean age, 3.5 years; range, 6 weeks to 16 years) with congenital and acquired heart disease treated with clopidogrel at doses ranging from 1 to 6mg/kg/day. They reported no thrombotic events, although one patient experienced gastrointestinal bleeding under triple antithrombotic therapy (clopidogrel, warfarin and acetylsalicylic acid).5
Soman et al. carried out a prospective study of 17 patients (mean age, 8.8 years; range, 1.5–17 years) that had suffered ischaemic strokes and were treated with clopidogrel because they did not tolerate or respond to treatment with acetylsalicylic acid. The prescribed doses of clopidogrel ranged between 0.5 and 2.4mg/kg/day. Two patients experienced subdural haematomas while receiving treatment with clopidogrel combined with acetylsalicylic acid.8
In a retrospective study that included 90 patients (mean age, 6.7 years; range, 11 days to 17.9 years) treated with clopidogrel (mainly for cardiac disease), Maltz et al. reported a mean dose of 1.3mg/kg/day (range, 0.2–8.9mg/kg/day) and haemorrhagic complications in 4.4%.2
When it comes to its pharmacokinetics, clopidogrel is quickly absorbed after oral ingestion, reaching its peak plasma concentration 45minutes after administration. It is estimated that less than 50% of the dose is absorbed (calculated based on the urinary excretion of its metabolites), and is then eliminated by the kidneys (50%) or in faeces (46%).1 Clopidogrel is a prodrug that has to be metabolised via CYP450 to produce the active metabolite that inhibits platelet aggregation. It is mainly metabolised via two metabolic routes: one that is esterase-mediated, leading to hydrolysis in its carboxylic derivative, and another that is mediated by multiple cytochrome P450 enzymes. The active metabolite, a thiol derived from clopidogrel, is mainly formed by the action of CYP2C19 with the contribution of various CYP enzymes, including CYP1A2, CYP2B6 and CYP3A4. As the action of cytochrome CYP2C19 is required for clopidogrel to be transformed into its active metabolite, we may expect that the greater the patient's enzymatic CYP activity, the more clopidogrel will be activated. Taking into account that the glomerular filtration rate is estimated to be 100–120mL/min/1.73m2 from age 1 year, similar to the rate in adults,10 and that the expression and activity of the cytochrome CYP enzymes increase with age (from birth until reachingadulthood),11 we did not find any justification from a pharmacokinetic or pharmacogenetic perspective for the differences in the dosage of clopidogrel based on age recommended in some publications: 0.2mg/kg/day for children under the age of 2, and 1mg/kg/day for children over the age of 2.
This does not mean that the pharmacogenetics of cytochrome CYP are not important in the dosing of clopidogrel. There are several studies that demonstrate the relationship between CYP polymorphisms and the antiplatelet activity of thienopyridines.12–14 As early as 2010, the European Medicines Agency (EMA) already warned that the efficacy of clopidogrel could be reduced with the concomitant use of omeprazole or esomeprazole or other CYP2C19 inhibitors (EMA/174948/2010). There is no doubt that pharmacogenetics and pharmacodynamics are important in the activity of clopidogrel.
We think that a possible explanation for the different doses found in the literature in children older than two years old may be due to the fact that the published studies are case series that include few patients where the existing pharmacogenetic differences in CYP cytochromes could have a significant effect and lead to different outcomes. Clinical trials in paediatric patients aged more than 24 months are needed in order to establish the optimal dosage of clopidogrel and its safety profile in this age group, allowing the development of an evidence-based treatment protocol.
In our study, a dose of clopidogrel of 0.2mg/kg/day was prescribed to all patients regardless of whether they aged more or less than 2 years, and 10 out of the 11 patients received concomitant treatment with acetylsalicylic acid. We consider the dose of 0.2mg/kg/day of clopidogrel effective, as no arterial thrombotic or thromboembolic events were documented. We also consider it a safe dose, since none of the patients experienced haemorrhagic complications, and the patients' platelet counts remained within normal ranges throughout the followup. Our study has the limitations intrinsic to a retrospective, observational and descriptive study based on a review of health records in a small population.
In our hospital, clopidogrel is usually prescribed to prevent arterial thrombotic and thromboembolic events associated with heart surgery or catheter-based interventions in patients with complex heart defects. In our experience, clopidogrel administered at a dose of 0.2mg/kg/day, in most cases in combination with acetylsalicylic acid (mean dose, 4.8mg/kg/day, range, 3.6–5.8mg/kg/day) proved to be a safe and effective strategy, regardless of patient age. However, we did not take into account genetic polymorphisms, which may help determine whether a patient may require higher or lower doses. The good tolerance observed in our study could be associated with having adjusted the optimal dose in order to achieve ADP-induced platelet aggregation without increasing the risk of adverse effects. We consider that the optimal dosage of clopidogrel should be determined based on the pharmacokinetic profile of the patient, and not on the patient's age.
Technical data sheet for Plavix 75mg coated tablets. Available from: https://cima.aemps.es/cima/dochtml/ft/98069001/FT_98069001.HTML
L.A. Maltz, K. Gauvreau, J.A. Connor, K.J. Jenkins.
Clopidogrel in a pediatric population: prescribing practice and outcomes from a single center.
Pediatr Cardiol, 30 (2009), pp. 99-105
http://dx.doi.org/10.1007/s00246-008-9289-x
J.S. Li, E. Yow, K.Y. Berezny, M. Takahashi, T.P. Graham Jr., S.P. Sanders, et al.
Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial.
Circulation, 117 (2008), pp. 553-559
Y. Finkelstein, L. Nurmohamed, M. Avner, L.N. Benson, G. Koren.
Clopidogrel use in children.
http://dx.doi.org/10.1016/j.jpeds.2005.05.006
C.A. Hanke, B. Stiller, L. Nakamura, J. Grohmann, B. Zieger.
Prophylactic use of clopidogrel in paediatric cardiac patients.
Klin Padiatr, 224 (2012), pp. 166-169
http://dx.doi.org/10.1055/s-0032-1306345 | Medline
L. Mertens, B. Eykens, D. Boshoff, M. Gewillig.
Safety and efficacy of clopidogrel in children with heart disease.
J Pediatr, 153 (2008), pp. 61-64
T. Soman, M.F. Rafay, S. Hune, A. Allen, D. MacGregor, G. deVeber.
The risks and safety of clopidogrel in pediatric arterial ischemic stroke.
Stroke, 37 (2006), pp. 1120-1122
E. Fernández Uzquiano, P. Lavilla Uriol, A. Gil Aguado.
Ensayos clínicos en pediatría.
An Pediatr Contin, 6 (2008), pp. 361-363
D.L. Wessel, F. Berger, J.S. Li, I. Dähnert, A. Rakhit, S. Fontecave, CLARINET investigators, et al.
Clopidogrel in infants with systemic-to-pulmonary-artery shunts.
N Engl J Med, 368 (2013), pp. 2377-2384
http://dx.doi.org/10.1056/NEJMoa1114588
C. Fernández, L. Espinosa.
Pruebas de función renal.
An Pediatr Contin, 6 (2008), pp. 93-97
D. Molina Ortiz, R. Camacho Carranza, A.M. Domínguez Ramírez, A. Vences Mejía.
Modulación de la expresión de enzimas del citocromo P450 hepáticas durante las etapas fetal y pediátrica.
Rev Educ Bioquímica, 31 (2012), pp. 60-71
L. Styles, D. Heiselman, L.E. Heath, B.A. Moser, D.S. Small, J.A. Jakubowski, et al.
Prasugrel in children with sickle cell disease: pharmacokinetic and pharmacodynamic data from an open-label, adaptive-design, dose-ranging study.
J Pediatr Hematol Oncol, 37 (2015), pp. 1-9
http://dx.doi.org/10.1097/MPH.0000000000000291 | Medline
M.J. Price, S.S. Murray, D.J. Angiolillo, E. Lillie, E.N. Smith, R.L. Tisch, et al.
Influence of genetic polymorphisms on the effect of high- and standard-dose clopidogrel after percutaneous coronary intervention: the GIFT (Genotype Information and Functional Testing) study.
J Am Coll Cardiol, 59 (2012), pp. 1928-1937
H. Visscher, U. Amstutz, J. Sistonen, C.J. Ross, M.R. Hayden, B.C. Carleton.
Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics.
J Cardiovasc Pharmacol, 58 (2011), pp. 228-239
http://dx.doi.org/10.1097/FJC.0b013e3182163b82
Please cite this article as: García CM, Roca CM, Núñez FR, Herranz MIM. ¿Cuál es la dosis óptima de clopidogrel en pacientes pediátricos? An Pediatr (Barc). 2019;90:219–223.
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redpajama_set_name: RedPajamaCommonCrawl


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I still haven't gotten my code, and I have done all that stuff. Could a mod please look into it?
I own the game, played several matches, verified my email address and opted in to receive the information. Also, I did it all before the 10th of May.


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As NBA Fines Irving, the Long…
Lack of Rebrand Indication that Diamond Sports' RSNs are in Trouble?
Last week we wrote a story entitled 'Sky Not Falling on Diamond Sports' RSN Business' making the case that the cable sports networks "drive consumption to levels exceeding everything else on television (save the NFL)" and thus the Sinclair (indirect) subsidiary would have "no problem retaining carriage – and pricing power – for their RSNs through the next negotiating cycle (think: 5-8 years)." But what happens if cable and satellite programmers continue to squeeze the RSNs on pricing (see: DISH) and the cost of sports broadcast rights keeps rising? Industry observer Ben Miller said "it's hard to imagine a scenario so dire that Diamond Sports is forced to file bankruptcy in 2020, but it's not beyond the realm of possibility if the company isn't able to generate the revenue needed to cover the debt service it took out to acquire the channels in the first place." That's because with $8.2 billion in debt on the RSNs, the $1.5 billion loss Sinclair (SBGI) would take if it filed bankruptcy might be its most palatable option. There's seemingly little chance another buyer would be willing to pay $9.7 billion plus for the lot of cable channels.
Howie Long-Short: Miller (founder of The Worldwide Reader in Sports & Entertainment) is particularly concerned that Sinclair has yet to rebrand the FOX Sports RSNs (closing occurred in August '19). He reasoned, "if Diamond Sports was still going through the carriage disputes (see: DISH, Sling, fubo TV), but had rebranded the properties and was expanding their content offerings one would assume the company had a plan and was going to weather the storm. It begs to wonder why Sinclair has been so reluctant to spend the money to go through this rebrand?"
Advocates of the RSN business have suggested that a direct-to-consumer business (along with a smaller MVPD bundle and sports betting) will "in aggregate" eventually off-set any losses associated with the melting of the cable bundle, but Miller doesn't see it that way. He insists that DTC is simply "a stalking horse the RSNs use in carriage negotiations and not a Pandoras box that they really want to open." That's because "with just +/- 5% of people with RSNs in their cable bundle watching more than one game/week, there is a fear that just +/- 5% of sports fans would be willing to pay a monthly subscription fee for the channel if it were sold ala carte. And if a cable or satellite provider could tell subscribers who wanted to watch the games that they could have access DTC, the cable and satellite companies would have even more pricing power over the RSNs [because there would be no pressure from customers to include the channels in the bundle]." Miller believes that maintaining widespread distribution through the bundle and pushing down on the amount of money being paid out to the teams – so that the math works out – is the optimal path forward for RSN owners.
Diamond Sports' existing agreement with Comcast expires in June. Should the RSNs be dropped (as Rich Greenfield projects) it will push the company closer to bankruptcy. Those who believe a new carriage deal will get done cite the potential for anti-trust lawsuits if Comcast were to retain carriage of its own RSNs and drop those owned by a competitor. But the problem with that logic is one could argue Comcast benefits if a lack of carriage ultimately forces Diamond Sports to push back on the amount of money its paying out for broadcast rights and Miller believes the company would be willing to limit carriage of its own RSNs to achieve that outcome. He said, "Comcast must have some level of regret as to how much they're paying teams. If the Detroit Tigers are forced into taking a haircut because Fox Sports Detroit is now in less homes, Comcast could theoretically push down on the amount of money it's paying out to teams on their own RSNs. And if lowering the amount of money going out to the teams is contingent upon placing their own RSNs in a more premium package (to avoid lawsuits), I think they would be OK with that tradeoff."
Fan Marino: MLS recently announced that the league is considering a plan that would see each clubs' local rights housed under a single roof. While not a concern specific to Diamond Sports, Miller finds the possibility of pro soccer leaving the RSNs troubling. "If MLS were to get a lucrative rights deal from [a digital first platform like] ESPN plus and viewership remained strong for teams in their local markets, there is the possibility that other leagues would follow suit." Of course, the subsequent loss of MLB, NBA or NHL rights from the RSN ecosystem would be catastrophic for the business model.
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Editor's Note: This piece originally ran on Sept. 4, 2020. We felt it would be appropriate to re-run it today. I was 10 years old when my father, Martin Luther King, Jr., was assassinated. And…
Martin Luther King III
Interactive Data Viz Chart for All 30 NBA Franchise Valuations
https://d3data.sportico.com/NBAVal/NBAVal.html?height=1500&width=1000
Lev Akabas, Peter J. Schwartz
From Knicks to Pelicans: 2021 NBA Franchise Valuations Ranking List
Sportico's 2021 NBA Franchise Valuations report includes a feature story as well as an interactive data visualization display. Below is a rank-order listing of all 30 NBA teams. !function(){"use…
Peter J. Schwartz
Three NBA Teams Top $5 Billion in Sportico's 2021 Franchise Valuations Report
The game between the Denver Nuggets and Dallas Mavericks reached the middle of the third quarter when an alert flashed on the phone handed to Mavericks' owner Mark Cuban. As of later that night, it…


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Philip Mendes
Associate Professor, Social Work
EmailPhilip.Mendes@monash.edu
Associate Professor Philip Mendes teaches Social Policy and Community Development, and is the Director of the Social Inclusion and Social Policy Research Unit in the Department of Social Work. His key research areas include young people transitioning from out-home-care, income security including compulsory income management, social workers and policy practice, illicit drugs policy, and Indigenous social policy. He is a member of the Transitions to Adulthood for Young People Leaving Public Care International Research Group, and a member of the Sydney Myer Fund Poverty and Disadvantage Grants Committee. He is the author or editor of 11 books, and the author of more than 100 peer-reviewed academic journal articles and book chapters. His latest book is the 3rd edition of the popular textbook, Australia's Welfare Wars, published by UNSW Press.
young people transitioning from out of home care
income security
Indigenous social policy
illicit drugs policy
social work activism
Indigenous care leavers in Australia: A national scoping survey
Mendes, P., Saunders, B., McCurdy, S., Standfield, R. & Burton, J.
Agency and autonomy: a cross-national study of compulsory income management policies
Marston, G., Mendes, P., Bielefeld, S. & Humpage, L.
Rights in records by design
Evans, J., Bone, J., McKemmish, S., Mendes, P., Reeves, K. & Wilson, J. Z.
Australian Research Council (ARC), Monash University, University of Ballarat
Evaluation of Salvation Army Westcare Continuing Care program
Mendes, P.
Transitioning from out of home care: A longitudinal population-based study
Chung, D., Cordier, R., Mendes, P., Thoresen, S., O'Donnell, M., Martin, R., Stratton, K. & Lund, S.
10 Short Review
4 Other Report
1 Foreword / Postscript
Empowerment and control in the Australian welfare state: A critical analysis of Australian social policy since 1972
Mendes, P., 2019, 1st ed. London: Routledge. 254 p. (Social Welfare around the World)
How the BDS movement is poisoning academic discourse
Mendes, P., 5 Feb 2019, In : Fathom: for a deeper understanding of Israel and the region. 22, p. 1-7 7 p.
Research output: Contribution to journal › Article › Other
Community as a spray-on solution: a case study of community engagement within the income management programme in Australia
Mendes, P., 1 Apr 2018, In : Community Development. 53, 2, p. 210-227 18 p.
Ending the victim-blaming
Mendes, P., 1 Nov 2018, In : Gesher. 5, 4, p. 69-73 5 p.
Research output: Contribution to journal › Article › Research
Hope Street: From Voice to Agency for Care-Leavers in Higher Education
Wilson, J. Z., Mendes, P. & Golding, F., 2 Feb 2018, (Accepted/In press) In : Life Writing. p. 1-13 13 p.


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UW Symphony at Benaroya Hall
Friday, January 23, 2015 - 7:30pm
Benaroya Hall 200 University St, Seattle, WA 98101 - Google Map
$22 general; $17 seniors; $12 students. Notecard. TICKETS: Benaroya Hall Box Office: 206.215.4747
Purchase tickets online here
Lodovic Morlot conducting student orchestra
The UW Symphony goes downtown for an evening of performance featuring School of Music faculty members: Ludovic Morlot and David Alexander Rahbee, conductors; Robin McCabe and Craig Sheppard, piano; and Joël-François Durand, whose composition Le Tombeau de Rameau III will be presented in its world premiere performance.
Durand: Le Tombeau de Rameau III
Poulenc: Concerto for Two Pianos and Orchestra
Robin McCabe, Craig Sheppard, piano
Tchaikovsky: Symphony No. 4 in F Minor, Op 36
Ludovic Morlot, conductor
David Alexander Rahbee
Conductor David Alexander Rahbee is a native of Boston. He studied conducting at the New England Conservatory, Université de Montréal, Universität für Musik und Darstellende Kunst in Vienna and at the Pierre Monteux School. He also studied violin and composition at Indiana University. He further refined his artistic training by participating in master-classes with Kurt Masur, Sir Colin Davis, Jorma Panula, Zdeněk Mácal, Peter Eötvös, Zoltán Peskó, Helmut Rilling and Otto-Werner Mueller.
In September 2013, he will become conductor of the orchestra at the University of Washington in Seattle, where he will work closely with Seattle Symphony Music Director Ludovic Morlot to build a new program for talented young conductors.
He was awarded the American-Austrian Foundation "Herbert von Karajan Fellowship" for young conductors in Salzburg (2003), as well as fellowships from International "Richard-Wagner-Verband-Stipend" in Bayreuth, Germany (2005), the Acanthes Centre in Paris (2007) and the Atlantic Music Festival in the USA (2010).
At the Salzburg Festival in 2003 he was assistant conductor of the International Attergau Institute Orchestra, where he also worked artistically with members of the Vienna Philharmonic Orchestra and guest conductors including Bobby McFerrin.
He has appeared in concert with the RTE National Symphony Orchestra of Ireland, Orchestre Philharmonique du Luxembourg, l'Orchestre de la Francophonie, the Dresden Hochschule Orchestra, Orquesta Sinfonica de Loja (Ecuador), the Armenian Philharmonic Orchestra, "Cool Opera" of Norway (members of the Stavanger Symphony), the Savaria Symphony Orchestra, Schönbrunner Schloss Orchestra (Vienna), the Gächinger Kantorei, the Bach-Kollegium Stuttgart, the Kammerphilharmonie Berlin-Brandenburg and the Divertimento Ensemble of Milan.
In the genre of contemporary musical theatre, Rahbee lead a fully staged production of Bruno Maderna's chamber opera Satyricon with the Divertimento Ensemble. He also lead this ensemble in the Italian premiere of Helmut Lachenmann's Mouvement – vor der Erstarrung.
The first of his several ground-breaking articles on Gustav Mahler, "Gustave Charpentier's Louise and Mahler's Sixth Symphony" appears in the spring 2013 edition of the music journal Sonus.
His arrangement of the Overture to Rossini's Barber of Seville for trombone quartet has been recorded and released on CD by Summit Music, played by the quartet known as Four of a Kind, four of the world's greatest trombonists. This arrangement, along with many others, is published by Warwick Music, England.
The French conductor Ludovic Morlot is Music Director of the Seattle Symphony. His first two seasons in this position have been received with huge enthusiasm by musicians and audience alike; who have appreciated not only the artistic excellence of the performances but his innovative programming and focus on collaborating with the local community. During the 2013/14 season he will conduct a gala concert with Lang Lang and works by many different composers including Boulez, Dusapin, Dvorak, Mahler, Verdi and full programmes of Ravel and Stravinsky. The orchestra will also perform at Carnegie Hall in New York, with a programme of works by John Luther Adams, Varese and Debussy.
Ludovic Morlot is also Chief Conductor of La Monnaie. This season he will conduct new productions of La Clemenza di Tito and Jenufa as well as concert performances in both Brussels and Aix-en-Provence, including Britten's War Requiem and Messiaen's Trois petites liturgies. During his first season as Chief Conductor, he conducted productions of Pelléas et Mélisande and Cosi fan tutteas well as Alfred Bruneau's Requiem.
During the 2013/14 season Ludovic will return to the Orchestre National de France and the Rundfunk-Sinfonieorchester Berlin. He will also close the BBC Symphony Orchestra's subscription season with a performance in the Barbican of Poulenc's Les Mamelles de Tiresias and Fauré's Requiem. Last season, Ludovic made his debut conducting at the Saito Kinen Festival in Japan and returned to the Royal Concertgebouw and Los Angeles Philharmonic Orchestras.
Ludovic Morlot has regular relationships with the New York Philharmonic and Chicago Symphony Orchestras and has recently conducted the symphony orchestras in Philadelphia, Cleveland and Pittsburgh. He also has a strong connection with the Boston Symphony Orchestra whom he conducts regularly in Boston and Tanglewood and recently also on a tour to the west coast of America. This relationship started in 2001 when he was the Seiji Ozawa Fellowship Conductor at the Tanglewood Music Center and subsequently appointed assistant conductor for the orchestra and their Music Director James Levine (2004-07).
In Europe, Ludovic has made recent debuts with the Czech Philharmonic and the London Philharmonic Orchestra and Anne Sophie-Mutter, whom he conducted at the Royal Festival Hall and on tour in Germany. Other recent notable performances have included the Dresden Staatskapelle, Tonhalle, Budapest Festival, Royal Stockholm Philharmonic and Tokyo Philharmonic Orchestras. Ludovic served as conductor in residence with the Orchestre National de Lyon under David Robertson (2002-04).
Trained as a violinist, Ludovic studied conducting at the Royal Academy of Music in London and then at the Royal College of Music as recipient of the Norman del Mar Conducting Fellowship. Ludovic was elected an Associate of the Royal Academy of Music in 2007 in recognition of his significant contribution to music. He is Chair of Orchestral Conducting Studies at the University of Washington School of Music in Seattle.
Joël-François Durand
Joël-François Durand is Professor of Music at the University of Washington, where he has taught composition, analysis, and theory since 1991. He has been Associate Director of the UW School of Music since 2002 and serves as Chair of the Composition Program.
Durand studied mathematics, music education, and piano in Paris, then composition with Brian Ferneyhough in Freiburg im Breisgau, Germany (1981-84). During that time he also attended masterclasses with György Ligeti, Luciano Berio and Luigi Nono. In 1982 Durand was awarded a scholarship from the DAAD (German Academic Exchange), and a Darmstadt Institute Scholarship for his String Trio. He received the "Kranichsteiner Musikpreis" from the Darmstadt Internationalen Ferienkurse in 1990.
He left Europe in 1984 to pursue a Ph.D. in Composition (awarded in 1988) at the University of New York, Stony Brook (USA), where he studied with Bülent Arel. He also studied electronic music with Daria Semegen.
Durand has composed for a wide variety of instrumental combinations. His music has been commissioned and performed by many leading ensembles and orchestras in Europe, the US, Brazil, and South Korea, including Ensemble Intercontemporain, London Sinfonietta, Contrechamps, Arditti Quartet, ASKO, Nieuw Ensemble, Ensemble Köln, Recherche, musikFabrik, New York Philomusica, Counter)Induction, EarPlay, BBC Symphony Orchestra, Orchestre Philarmonique de Radio France, and Deutsches Symphonie Orchester Berlin.
Robin McCabe
Chair of the keyboard program at the University of Washington, celebrated American pianist Robin McCabe has enthralled audiences across the United States, Europe, Canada, South America, and the Far East in an international performance career spanning several decades. The New York Times observed, "What Ms. McCabe has that raises her playing to such a special level is a strong lyric instinct and confidence in its ability to reach and touch the listener." The Tokyo Press declared her a "pianistic powerhouse," and Richard Dyer, the eminent critic of the Boston Globe noted, 'Her brilliant, natural piano playing shows as much independence of mind as of fingers."
A native of Puyallup, McCabe earned her bachelor of music degree summa cum laude at the University of Washington School of Music, where she studied with Béla Siki, and her master's and doctorate degrees at the Juilliard School of Music, where she studied with Rudolf Firkusny. She joined the Juilliard faculty in 1978 then returned to the UW in 1987 to accept a position on the piano faculty. In 1994 McCabe was appointed Director of the School of Music, a position she held until 2009. She has held a Ruth Sutton Waters Professorship and a Donald Petersen Professorship in the School of Music. In addition, McCabe is a dedicated arts ambassador and advocate for arts audience development, frequently addressing arts organizations across the country. With colleague Craig Sheppard, she launched the highly successful Seattle Piano Institute, an intense summer "immersion experience" for gifted and aspiring classical pianists.
McCabe performs regularly throughout the United States, and in 2011 made her first visit to South Korea. She appears often as an invited jurist for international piano competitions, most recently in New Orleans, San Antonio, and Vancouver, Canada. In June of 2016 she will serve on the jury for the international Gina Bachauer Competition for piano.
A native of Philadelphia and a graduate of both the Curtis Institute of Music and the Juilliard School, Professor of Piano Craig Sheppardcame to the University of Washington in 1993 after living twenty years in London. Winning the Silver Medal at the 1972 Leeds International Pianoforte Competition in the UK, he moved there shortly thereafter, performing subsequently with all the major British orchestras, many on the European continent, a number in this country - including Chicago, Boston, Philadelphia, San Francisco and Seattle - and appearing with many leading conductors of the day. While in London, he taught at the Yehudi Menuhin School and the Guildhall School of Music and Drama, and gave numerous master classes at both Oxford and Cambridge universities.
In recent years, in addition to a highly acclaimed recital at the Berlin Philharmonic, Sheppard has traveled frequently to the Far East, India, Australia and New Zealand to teach and perform. In late March, he visits China for the third time to perform the 24 Preludes and Fugues of Shostakovich at the Shanghai Conservatory and the Forbidden City Concert Hall in Beijing, culminating in a performance and recording of the Shostakovich in Seattle's Meany Theater on April 25th.
Sheppard has collaborated with many of the most celebrated instrumentalists and singers of the day, and his CDs have garnered excellent reviews consistently from such diverse publications as Gramophone, International Record Review and Fanfare. His students have won prizes in major competitions and hold positions in universities and conservatories throughout this country, Europe and Asia. With colleague Robin McCabe, he will host the fifth annual Seattle Piano Institute this July at the School of Music. For more information, see www.craigsheppard.net and http://blogs.uw.edu/seapiano/.
University of Washington Symphony Orchestra


We are thrilled to introduce to you our new maternity bridal designs for Spring/Summer 2019. Our luxury maternity wedding collection is the epitome of graceful serenity. From ceremony to wedding breakfast to first dance, feel incredible in enchanting laces and silky satin jerseys across a beautiful range of styles. Choose from long and short wedding styles crafted out of luxurious laces and silky premium jerseys - the perfect combination for pregnant brides. All lovingly designed and made in Britain.


Consumer Reports will publish detailed ratings of consumer electronics products beginning Wednesday at technology news site ZDNet. The Yonkers, N.Y.-based ratings organization originally agreed to publish its information on ZDNet--owned by San Francisco-based CNET Networks--in October. ZDNet Equip users will have access to Consumer Reports' comprehensive purchasing advice summaries, including product features and trends. ZDNet users will also be able to purchase a complete Consumer Reports ratings and recommendations guide through a co-branded site. Consumer Reports rankings are also available at CNET Computers.com and CNET's mySimon site. CNET Networks is the publisher of ZDNet and News.com.
Consumer Reports will publish detailed ratings of consumer electronics products beginning Wednesday at technology news site ZDNet. The Yonkers, N.Y.-based ratings organization originally agreed to publish its information on ZDNet--owned by San Francisco-based CNET Networks--in October.
ZDNet Equip users will have access to Consumer Reports' comprehensive purchasing advice summaries, including product features and trends. ZDNet users will also be able to purchase a complete Consumer Reports ratings and recommendations guide through a co-branded site. Consumer Reports rankings are also available at CNET Computers.com and CNET's mySimon site.
CNET Networks is the publisher of ZDNet and News.com.


With high-performance curtain walls and windows, thermal bridge-free designs, and airtight building enclosures, more U.S. projects seek to achieve the rigorous European-based Passivhaus standard.
As the pursuit of sustainable, energy-efficient buildings continues to intensify, a more rigorous building design certification is starting to gain traction here in North America.
Originally developed in Germany in 1990 and well-established in Europe, the Passivhaus standard produces extremely low-energy buildings with high-performance, airtight building enclosures.
"One of the most effective and proven tools we have to drive down carbon emissions and reach a post-carbon world is Passive House," say Bronwyn Barry and Ken Levenson, co-presidents of the North American Passive House Network (NAPHN) in Passive House Accelerates, an in-depth review of the standard's development for residential and commercial buildings—called Passive House in lieu of Passivhaus—in North America.
Click here to view the full course via Architectural Record's Continuing Education portal.


In Chiang Mai, Songkran is often called Paweni Pi Mai Muang. Here you'll find a wonderful balance of water-based fun and sacred ceremonies that show the religious importance of this festival to the Lanna people. Highlights include the procession of Chiang Mai's prominent Phra Buddha Sihing image as well as bathing the image, and taking part in a parade bringing sand and Sali (the Bodhi tree) clutches to temples, cultural events and performances.
For more information, contact TAT Chiang Mai Office at 053-248-604-5, TAT Call Center at 1672, or visit TAT Chiang Mai.


Me and my hair have a bit of a frenemie relationship. I have battled with my hair since the day I was born. First there was the ginger thing- now, hear me out. I now love my ginger hair, red is c'est chic now, but let's be honest, there were downsides of being a 'carrot top' when you were a 12 year old shy, nerdy kid. But hey, water under the bridge!
But then, my hair took a second blow to me, it is naturally very curly, very frizzy, and very dry. So to cut a long story short, it's been a long uphill battle since day dot.
Needless to say, when milestone events come along, such as my impending graduation, I keep my fingers crossed it's going to behave for me. So to help it along I've been pampering it and giving it extra love lately, with a little help from a couple of products from Neal & Wolf and Label.m.
For actually washing and conditioning, I cannot part from Tresemme, however for that extra TLC, I've started using an Intensive Care Treatment.
For any type of damaged or over processed hair, you should always use a intensive conditioner to help give it an extra moisture boot to help it repair. After I've shampoo'd and conditioned normally, I'll step out of the shower, slather this all on, and pile my hair high on my head. Ideally, the longer you leave you hair the better, but I know time isn't always unlimited, so I leave it on while I do an intensive exfoliation so up to around 10 minutes.
Now for Graduation Ball, I want lots of volume in my hair, a la Cheryl Cole. Normally I don't use any extra products, as I find I always seem to end up with cake-y clogged up product in my hair. However I thought I'd try again. I've been experimenting with 2 products for the last few weeks, to perfect my technique, and I am very happy with the results.
First I've been using Neal & Wolfs Volumising lotion, which you apply to towel dry hair and blow dry. If your hair is naturally curly like mine, and you don't straighten it unlike me, apply this and tip your head upside down, and using a diffuser nozzle, blow dry and scrunch your hair. I promise your hair will be massive!
However, I've also been using label.m resurrectionstyle dust for the final touch. It is a very fine powder, a little more creamy than talc, which can be used to create a variety of styles. I've used it to back comb small sections of my roots, and its worked wonders as it holds together the hair and creates extra lift, giving my hair roots extra height.
I haven't personally, but my housemate tried it to create some texture in her fine hair, and stopped her style from dropping out as quick, which fine hair often does.
You might remember last week I went out for dinner and drinks with my friends. Well I had used all three of these products that night, and I personally think my hair was pretty fabulous (if I do say so myself).
Only 1 week now till Graduation Ball, I'm really excited. There is going to be a circus, and bands, and lots of gorgeous dresses to lust after.
If you still haven't found your perfect dress yet, I've put together a collection of Graduation Ball dress ideas that may help you.
Also if you have any beauty tips for me too, I'd love to hear them.
If you like my blog, you can follow me on bloglovin' to keep up to date.
Cool pics! I really like them!
you hair looked lovely :)!
LOVE that dress, you look gorgeous!


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Vivienne Franzmann
A gripping and urgent play about a well-meaning teacher who intervenes on behalf of a troublesome student, with terrifying consequences. Joint Winner of the Bruntwood Prize for Playwriting 2008.
When white secondary-school teacher Amanda is pushed to the ground by black student Jason, she's reluctant to report him as she knows exclusion could condemn him to a future as troubled as his past.
But when Jason decides to protect himself by spinning a story of his own, Amanda is sucked into a vortex of lies in which victim becomes perpetrator. With the truth becoming less clear and more dangerous by the day, it isn't long before careers, relationships and even lives are under threat.
'A tough, gripping spectacle' Guardian
'Outstanding… Franzmann manages to make all the characters credible and well-rounded, even the damaged perpetrator… She gets to the rotten core of what's going on in these melting-pot battlegrounds… The play of the year? In my book, quite possibly' Dominic Cavendish,Telegraph


at our Supported Living Project in central Bognor Regis.
The holders of this post within the Aldingbourne Trust are responsible for enabling our tenants to live the lives they choose safely, while developing their own independence. This means supporting people in their homes, in the community and on holiday.
You will work as part of a team with staff and the people we support to ensure that the emotional, social, medical and material needs of people are recognised, assessed and met.
Over the age of 18 and have a full manual driving licence.
Flexible to work on a rota to fit the needs of the project and the people we support.


Award summary and conditions: The Luce Scholars Program offers an intensive experience in Asia for those who would not, in the normal course of their careers, have such exposure. The Luce Scholars Program is experiential rather than academic in nature. Some Scholars are placed at Asian universities in teaching or research capacities, but none is formally enrolled as a student in a college or university and no academic credit is extended.
Letters of recommendation (4) - range of academic and professional references.
Selection process: An interview with each nominee will be held in November or December in person or via skype or telephone. In early January, about 45 finalists will be selected. Each will meet with one of three independent selection committees in late January and early February. Travel expenses will be paid by the Luce Scholars Program. From each committee, five or six Luce Scholars will be chosen.
Announcement date: Recipients will be notified by early February.


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NASA finds light rain in fading Tropical Depression 21E
by Rob Gutro, NASA's Goddard Space Flight Center
The GPM core satellite passed over Tropical Depression 21E in the Eastern Pacific Ocean on Nov. 18 at 0046 UTC (Nov. 17 at 7:46 p.m. EST) and found a few areas of light rain (blue) falling at a rate of 0.4 inches (10 mm) per hour and one small area of heavy rain (orange) where rain was falling at a rate of 1 inch (25 mm) per hour. Credit: NASA/JAXA/NRL
Tropical Depression 21E never matured into a tropical storm and a NASA analysis of rainfall rates show the storm won't have that chance.
NASA has the unique capability of peering under the clouds in storms and measuring the rate in which rain is falling. Global Precipitation Measurement mission or GPM core passed over Tropical Depression 21E (TD21E) from its orbit in space and measured rainfall rates throughout the storm.
TD21E formed on Saturday, Nov. 16 and maintained depression status over the weekend.
The GPM's core satellite passed over TD21E in the Arabian Sea, Northern Indian Ocean on Nov. 18 at 0046 UTC (Nov. 17 at 7:46 p.m. EST) and found a few areas of light rain falling at a rate of 0.4 inches (10 mm) per hour. There was one small area north of the center where heavy rain was falling at a rate of 1 inch (25 mm) per hour, but forecasters said that area "doesn't seem to be directly associated with the depression's circulation." Forecasters incorporate the rainfall data into their forecasts.
NOAA's National Hurricane Center or NHC noted at 4 a.m. EST (0900 UTC), the center of TD21E was located near latitude 12.2 north, longitude 105.0 west and is located about 470 miles (760 km) south of Manzanillo, Mexico.
The depression is moving toward the northwest near 7 mph (11 kph). A westward motion at a slower forward speed is expected for the next couple of days.
Maximum sustained winds are near 30 mph (45 kph) with higher gusts. The estimated minimum central pressure is 1007 millibars.
The depression is expected to become a remnant by early Tuesday and dissipate by Wednesday night or Thursday, Nov. 21.
NASA finds heavy rainfall along Central Philippine Coast from Tropical Depression Kalmaegi
Provided by NASA's Goddard Space Flight Center
Citation: NASA finds light rain in fading Tropical Depression 21E (2019, November 18) retrieved 21 January 2020 from https://phys.org/news/2019-11-nasa-tropical-depression-21e.html
NASA finds small area of heavy rain left in Tropical Cyclone Kyarr
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Heavy rainfall found in Tropical Storm Lorenzo by NASA


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Goodbye, First Amendment: 'Trespass Bill' will make protest illegal
Just when you thought the government couldn't ruin the First Amendment any further: The House of Representatives approved a bill on Monday that outlaws protests in instances where some government officials are nearby, whether or not you even know it.
The US House of Representatives voted 388-to-3 in favor of H.R. 347 late Monday, a bill which is being dubbed the Federal Restricted Buildings and Grounds Improvement Act of 2011. In the bill, Congress officially makes it illegal to trespass on the grounds of the White House, which, on the surface, seems not just harmless and necessary, but somewhat shocking that such a rule isn't already on the books. The wording in the bill, however, extends to allow the government to go after much more than tourists that transverse the wrought iron White House fence.
Under the act, the government is also given the power to bring charges against Americans engaged in political protest anywhere in the country.
Under current law, White House trespassers are prosecuted under a local ordinance, a Washington, DC legislation that can bring misdemeanor charges for anyone trying to get close to the president without authorization. Under H.R. 347, a federal law will formally be applied to such instances, but will also allow the government to bring charges to protesters, demonstrators and activists at political events and other outings across America.
The new legislation allows prosecutors to charge anyone who enters a building without permission or with the intent to disrupt a government function with a federal offense if Secret Service is on the scene, but the law stretches to include not just the president's palatial Pennsylvania Avenue home. Under the law, any building or grounds where the president is visiting — even temporarily — is covered, as is any building or grounds "restricted in conjunction with an event designated as a special event of national significance."
It's not just the president who would be spared from protesters, either.
Covered under the bill is any person protected by the Secret Service. Although such protection isn't extended to just everybody, making it a federal offense to even accidently disrupt an event attended by a person with such status essentially crushes whatever currently remains of the right to assemble and peacefully protest.
Hours after the act passed, presidential candidate Rick Santorum was granted Secret Service protection. For the American protester, this indeed means that glitter-bombing the former Pennsylvania senator is officially a very big no-no, but it doesn't stop with just him. Santorum's coverage under the Secret Service began on Tuesday, but fellow GOP hopeful Mitt Romney has already been receiving such security. A campaign aide who asked not to be identified confirmed last week to CBS News that former House Speaker Newt Gingrich has sought Secret Service protection as well. Even former contender Herman Cain received the armed protection treatment when he was still in the running for the Republican Party nod.
In the text of the act, the law is allowed to be used against anyone who knowingly enters or remains in a restricted building or grounds without lawful authority to do so, but those grounds are considered any area where someone — rather it's President Obama, Senator Santorum or Governor Romney — will be temporarily visiting, whether or not the public is even made aware. Entering such a facility is thus outlawed, as is disrupting the orderly conduct of "official functions," engaging in disorderly conduct "within such proximity to" the event or acting violent to anyone, anywhere near the premises. Under that verbiage, that means a peaceful protest outside a candidate's concession speech would be a federal offense, but those occurrences covered as special event of national significance don't just stop there, either. And neither does the list of covered persons that receive protection.
Outside of the current presidential race, the Secret Service is responsible for guarding an array of politicians, even those from outside America. George W Bush is granted protection until ten years after his administration ended, or 2019, and every living president before him is eligible for life-time, federally funded coverage. Visiting heads of state are extended an offer too, and the events sanctioned as those of national significance — a decision that is left up to the US Department of Homeland Security — extends to more than the obvious. While presidential inaugurations and meeting of foreign dignitaries are awarded the title, nearly three dozen events in all have been considered a National Special Security Event (NSSE) since the term was created under President Clinton. Among past events on the DHS-sanctioned NSSE list are Super Bowl XXXVI, the funerals of Ronald Reagan and Gerald Ford, most State of the Union addresses and the 2008 Democratic and Republican National Conventions.
With Secret Service protection awarded to visiting dignitaries, this also means, for instance, that the federal government could consider a demonstration against any foreign president on American soil as a violation of federal law, as long as it could be considered disruptive to whatever function is occurring.
When thousands of protesters are expected to descend on Chicago this spring for the 2012 G8 and NATO summits, they will also be approaching the grounds of a National Special Security Event. That means disruptive activity, to whichever court has to consider it, will be a federal offense under the act.
And don't forget if you intend on fighting such charges, you might not be able to rely on evidence of your own. In the state of Illinois, videotaping the police, under current law, brings criminals charges. Don't fret. It's not like the country will really try to enforce it — right?
On the bright side, does this mean that the law could apply to law enforcement officers reprimanded for using excessive force on protesters at political events? Probably. Of course, some fear that the act is being created just to keep those demonstrations from ever occuring, and given the vague language on par with the loose definition of a "terrorist" under the NDAA, if passed this act is expected to do a lot more harm to the First Amendment than good.
United States Representative Justin Amash (MI-03) was one of only three lawmakers to vote against the act when it appeared in the House late Monday. Explaining his take on the act through his official Facebook account on Tuesday, Rep. Amash writes, "The bill expands current law to make it a crime to enter or remain in an area where an official is visiting even if the person does not know it's illegal to be in that area and has no reason to suspect it's illegal."
"Some government officials may need extraordinary protection to ensure their safety. But criminalizing legitimate First Amendment activity — even if that activity is annoying to those government officials — violates our rights," adds the representative.
Now that the act has overwhelmingly made it through the House, the next set of hands to sift through its pages could very well be President Barack Obama; the US Senate had already passed the bill back on February 6. Less than two months ago, the president approved the National Defense Authorization Act for Fiscal Year 2012, essentially suspending habeas corpus from American citizens. Could the next order out of the Executive Branch be revoking some of the Bill of Rights? Only if you consider the part about being able to assemble a staple of the First Amendment, really. Don't worry, though. Obama was, after all, a constitutional law professor. When he signed the NDAA on December 31, he accompanied his signature with a signing statement that let Americans know that, just because he authorized the indefinite detention of Americans didn't mean he thought it was right.
Should President Obama suspend the right to assemble, Americans might expect another apology to accompany it in which the commander-in-chief condemns the very act he authorizes. If you disagree with such a decision, however, don't take it to the White House: Sixteen-hundred Pennsylvania Avenue. The vicinity is of course, covered under this act.
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Mario Tama ( mariotama ), Getty Images photographer. Currently based in Rio de Janeiro, Brazil by way of New York City.
Jessica Ennis-Hill ( jessicaennishill ) takes a selfie with Usain Bolt.
As a result, today's professional photographers have to be more creative and more innovative than their predecessors. They have to develop a unique sense of what makes a photograph historically important. And even then, there's a chance that someone will have the same idea; remember that iconic photograph of Usain Bolt smiling over his shoulder during the 100 metre heat? Well, there are actually two of these .
Cameron Spencer ( cjspencois ), Sydney based Getty Images staff photographer.
Bob Martin ( bubblesontour ), photographer and grandfather.
Gary Hershorn ( garyhershorn ), NYC based photographer and photo editor. Former Reuters, now contributing to SilverHub Media and Getty Images.
Adam Pretty ( adampretty ).
Fun social media stories are also a big hit at the games, as was true of US athlete Ben Kanute , who staged his own opening ceremony, when he couldn't make the official one.
Mark Reis ( mark.reis ).
Donald Miralle ( donaldmiralle ), Photographer, Waterman, Husband, Father.
David Burnett ( davidburnettfoto ), freelance photographer for National Geographic.
David Ramos ( davidramosgetty ) staff photographer with Getty Images in Barcelona.
Lucy Nicholson ( lucynic ) Reuters senior staff photographer. Born in London; based in LA, covering news, sport and features.
Jed Jacobsohn ( jedjacobsohn ).
Anthony Edgar ( anthonyedgar888 ).
Christophe Simon ( christophesimonafp ).
John Lehmann ( johnlehmann ), staff photojournalist with the Globe and Mail based in Vancouver, Canada.


i am up for suggestions on names for my dragons just comment and i'll have a look.
i'm working on a new dragon he is a jungle dragon with a background and he is going to be awesome. when he is done i will post him…….. i still don't have a name for him.


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Online Resources for Book History and Print Culture
Paper, Parchment, Pens: The Raw Materials
A growing selection of websites, articles, and videos which help explain aspects of book culture and material history.
Writing Surfaces
Putting Letters on the Page
Decorating Paper
Paleography: Reading Historical Handwriting
Writing in the Ancient World
The Book Before the Printing Press
The Hand Printed Book
The Book in the Industrial Era
Further Reading and Watching
Resources at Williams Available for Video Demo
Cuneiform Tablets
A graduate student at UCLA explains her work to decipher a group of cuneiform tablets, which were first used in Sumeria more than 4000 years ago, and demonstrates how how they were created using clay and a reed stylus.
A demonstration of the Sri Lankan process of preparing ola leaves, using a stylus to incise letters, and binding the finished book in wooden covers. Palm leaf manuscripts were produced in South and Southeast Asia as early as the 5th century BCE.
Washi: Japanese Handmade Paper
The technique of making paper from the mulberry plant was first developed in Japan in the 8th century.
Tapa Cloth
In the Pacific Islands, the inner bark of the paper mulberry tree is beaten to create tapa, a barkcloth.
Xuan Paper
In China, paper has been made by hand from rice straw and sandalwood bark since the 8th century.
Wax Tablets
A discussion of surfaces used for informal writing in ancient Greece and Rome as early as the 7th century BCE.
How Parchment is Made
A BBC segment on an English parchment maker who produces writing skins using traditional methods nearly identical to those used in Europe during the middle ages.
Parchment (the good, the bad, and the ugly)
This Smarthistory site gives a good overview of the materiality of medieval European writing on parchment.
Hand Papermaking in Fabriano
Artisans in Fabriano, Italy, have been making paper by hand since the 13th century. Today, the Fabriano mill demonstrates the integration of traditional techniques with industrial-era innovations.
Papermaking at the Hayle Mill
English papermakers produce cotton-fiber paper by hand, using many of the same techniques which have been employed since the hand press era. Paper was introduced to Europe from the Middle East in the 11th century, but the first paper mill in England was not established until 1490.
The Eagle Paper Machine
In the 19th century, steam power and other technological advances radically changed the way paper was made. Although it was built as a miniature demonstration model in 1914, the paper machine featured in this video uses processes typical of the later part of the 19th century.
Where did Writing Begin?
A brief introduction to the development of six ancient writing systems, from Mesopotamia to Rapa Nui.
Cracking Ancient Codes: Cuneiform Writing
An extensive and entertaining talk by British Museum curator Irving Finkel on the ancient use and recent decipherment of cuneiform, the world's oldest writing system.
Making Manuscripts: Quills
Preparing a feather quill pen with methods commonly used in Europe between the 7th and 19th centuries.
Suminagashi: Japanese Marbling Technique
Suminagashi, or water marbling, has been practiced in Japan since the 12th century.
Ebru: Turkish Paper Marbling
Marbled paper has been made in Turkey since at least the 16th century. The technique of marbling spread from Turkey and the Middle East to Europe in the 17th century, when it was commonly used for endpapers and bindings.
Art of the Marbler: The Cockerell Workshop in England
The British firm of Cockerell and Sons produces marbled paper using traditional European techniques. Of particular interest is the use of combs to produce repeatable patterns.
These resources will help develop skills in reading historical Latin and English handwriting.
Latin Palaeography from the Hill Museum and Manuscript Library
A user-friendly basic introduction to a variety of scripts from the ancient world to the early modern era.
English Handwriting 1500-1700: An Online Course
Intended for intermediate and advanced users, this site's interface is somewhat clunky, but detailed notes on the dating of each document and extensive supplementary materials make it a useful resource.
Early Modern Handwriting: Alphabets
A great quick reference for English alphabets, circa 1500-1700. Particularly useful for learning about what individual letters and abbreviations look like in their historical forms.
UK National Archives Tutorial in Palaeography, 1500-1800
A thorough introduction to early modern English scripts. The quick reference guide to dating, numbers, and other abbreviations is particularly helpful. Extensive exercises allow students to practice skills: each of 10 documents includes historical background notes ;a glossary; notes on the palaeography; a sample alphabet taken from each document, and a full transcript.
Script Tutorial: The English Documents
Extensive site created by Brigham Young University with resources for reading English scripts created between 1600 and 1800. Sample transcriptions and interactive exercises make it easy to practice.
Medieval Writing: Index of Scripts
This site, which is now only available through the Internet Archive, does a deep dive into European handwriting styles. The Index of Scripts page offers more granular detail and more examples than are available through the other links in this section.
Next: Writing in the Ancient World >>
Last Updated: Nov 25, 2020 12:27 PM
URL: https://libguides.williams.edu/onlineresourcesforbookhistory
Subjects: Art History, Classics, English, History, Science and Technology Studies
Tags: book history


PALO ALTO, Calif., March 7, 2011 – In conjunction with the official release of Microsoft's Windows MultipPoint Server 2011 shared resource OS, DisplayLink™ Corp. has released its production drivers.
Downloadable from the DisplayLink Download Page, the DisplayLink version 5.6 drivers feature improved performance and other enhancements to complement Windows MultiPoint Server 2011 compatible thin client and zero client components.
DisplayLink's USB virtual graphics technology leverages Windows MultiPoint Server 2011 to enable a greater than 10-seat zero-client solution – ideal for schools and other markets where a PC-per-person isn't possible. DisplayLink software and silicon allow one host computer to connect with 10 or more separate monitors via simple USB connections, saving time and money.
With the release of the Windows MultiPoint Server 2011 driver support, DisplayLink continues to reinforce its leadership position in the USB connected zero client market and also shows its ongoing commitment to this growing sector. DisplayLink anticipates a variety of new zero client hardware products featuring USB graphics technology to reach the market this month.


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Susan Burnett Comments on New Jersey Supreme Court Reglan Ruling In Law360
On Monday, August 22nd, the New Jersey Supreme Court ruled that state law claims alleging generic-drug manufacturers didn't adequately warn of neurological risks for Reglan aren't preempted by federal law. This decision has widened the emerging appellate court split on the issue of generic label preemption, which could make it's way before the U.S. Supreme Court for resolution.
Susan Burnett, partner in the firm's Austin office, commented on the ruling's impact on generic-drug manufacturers as well as consumers in future litigation.
"The 2004 label update was relatively small as it changed from saying that using Reglan beyond 12 weeks hadn't been evaluated and therefore couldn't be recommended to warning that Reglan shouldn't be used after 12 weeks, according to Susan Burnett of Bowman and Brooke LLP. The consumers will have to show that this minor change would have caused doctors to hold off from prescribing the drug for more than 12 weeks in order to show proximate cause, Burnett said."
She went on to say in Law360, "It's not the end of the ball game — [the drugmakers have] lost the battle but not lost the war..."
Read Law360's full article, NJ Reglan Ruling Widens Generic Label Preemption Split.
Susan E. Burnett
Partner, Austin


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KNCT Radio 4+
CENTRAL TEXAS COLLEGE
Central Texas public radio station KNCT-FM signed on the air in November 1970 from studios located on the campus of Central Texas College in Killeen, Texas. During the early years, KNCT-FM operated on a limited broadcast schedule of 2 p.m. until 10 p.m. Monday through Friday. Today, the station programs a beautiful music format combined with news, weather, and public affairs, operating 24 hours a day, seven days a week. Broadcasting with 50,000 watts of power from a transmitter located near Stillhouse Hollow Reservoir, KNCT-FM serves a wide area of Texas including Killeen, Copperas Cove, Belton, Temple, Waco, Georgetown, Round Rock, and Austin.
We provide programming of the highest quality that is not available on commercially formatted radio stations including our primary format of Simply Beautiful music, as well as a variety of public service and special interest programs. These include public affairs (Senior Report), outdoor sports (On the Dock), national news from the Associated Press, features (Stardate and Sounds of Texas), plus music shows that are designed for our specific audience. These include Sock Hop Saturday Night (oldies), and two programs that spotlight the Big Band era – Swingin' Down the Lane and Big Band Sunday. Our HD radio audience can tune to 91.3-2 for our Simply Classical channel, or listen live on the KNCT-FM website. KNCT-FM also serves as a laboratory facility for students enrolled in the Communication and Media Technology Program of central Texas College.
KNCT-FM is partially funded through grants from Central Texas College and the Corporation for Public Broadcasting and through generous donations from listeners like you. Donations to KNCT-FM are tax-deductible to the extent allowed by law.
Version 10.1.33
Bug fixes and performance improvements.
Texasukraine , 12/26/2018
KNCT great local station
Was very pleased when found this live stream app for KNCT. Great local station, have been listening to it for years. Great job CTC!
ClintDoggy 87 , 12/27/2020
Amazing station!
This is a great station. The music is very relaxing and easy to listen too. I have it on all the time!
Mark20191986 , 10/11/2019
Absolutely the best station! I'm glad they have an app so I can listen to it in Alabama.
The developer, CENTRAL TEXAS COLLEGE, indicated that the app's privacy practices may include handling of data as described below. For more information, see the developer's privacy policy.
© 2021 Securenet Systems, Inc.
CTC Radio
Nest FM
91.3 Hope FM
Grand Avenue Theater
Texas Rebel Radio
Boerne Radio
95.3 The Range


For updates on the Boca National golf course progress, please see the Greater Boca Raton Beach and Park District website Opens a New Window. .
At the February 13 City Council meeting, the City Council passed a budget amendment, resolution and ordinance authorizing the issuance of a revenue bond not to exceed $20,000,000 to provide funds on behalf of the Greater Boca Raton Beach & Park District for acquisition of the Ocean Breeze property. This property will be used for recreational and related facilities for the benefit of City and District residents.
The District is in the process of hiring and coordinating consultants and contractors to begin the redevelopment of the 27-hole golf course.
Resolution 10-2018, the Interlocal Agreement with the Greater Boca Raton Beach and Park District was adopted and the ordinances pertaining to the City Bond and City Budget Amendment were introduced.
Consideration of the City Bond Ordinance and City Budget Amendment will be considered at the February 13, 2018 City Council Meeting.
At the City Council Workshop on January 8, 2018, City staff gave a presentation of the draft interlocal agreement between the City and the Greater Boca Raton Beach and Park District (GBRBPD) for the financing, terms and conditions relating to the purchase of the Ocean Breeze Golf Course.
On January 16, 2018, the Beach and Park District Board of Commissioners unanimously approved the revised Interlocal Agreement for the Ocean Breeze financing. A signed copy of the agreement will be provided to City Council prior to consideration of the matter at the January 23 regular meeting. The Interlocal Agreement includes the revisions discussed by City Council at the January 8 workshop meeting, as described in the agenda materials for the matter.
At the meeting, the GBRBPD also discussed presentations by the 15 firms that responded to the District's Request for Proposals for a golf course designer/architect, and determined to open those presentations to the public. District staff advises that the 15 proposals and the RFP document will be posted on the District's website mybocaparks.org by January 20th.
January 29, 2018 (Monday) beginning at 5:30 p.m.
February 1, 2018 (Thursday) beginning at 5:30 p.m.
February 12, 2018 (Monday) beginning at 5:30 p.m.
Each meeting will consider five presentations from the proposers. The exact schedule of the proposers will be determined. The public is welcome to attend the presentations, but public comment will not be taken at these presentations. After the presentations are completed, the public will have an opportunity to comment at a regular District Board meeting prior to the Board's decision to proceed.
The Greater Boca Raton Beach & Park District Acquisition Reports have been removed. Please contact the Greater Boca Raton Beach and Park District for questions.
The Boca Raton City Council and the Greater Boca Raton Beach & Park District are working together to keep golf in Boca Raton with the District's purchase of the Ocean Breeze Golf Course.
On Tuesday, September 26, 2017, the Boca Raton City Council and the Greater Boca Raton Beach and Parks District (GBRBPD) held a third joint public meeting to discuss the 27 hole Ocean Breeze Golf Course located at 5801 NW 2nd Ave.
Mayor Susan Haynie requested additional information from the GBRBPD so the Council could make a decision on the amount of funding, but City Council members agreed that they would like to keep the land as a golf course in Boca Raton. The Mayor directed City staff to begin drawing up an interlocal agreement between the agencies.
At a City Council meeting on Tuesday, May 9, the Council again reiterated its interest in partnering with the District to purchase the Golf Course, but indicated they were waiting on additional information before a final decision on the amount could be made. City Manger Leif Ahnell discussed the different bond financing options and the timing of the process.


Ask Us Anything – August 2018!
1 Year of great questions!
Who can believe it's 1 year since we started this series! Welcome to our anniversary episode and thank you for all the questions you have all sent to us each month, we've had a great time answering them.
SPOILER ALERT: This month we were handed another crazy music video challenge – MUST WATCH!
To have our team of music geniuses answer your questions next month make sure to leave it in the comment section below or on our social media channels.


Self-driving cars could eventually save the U.S. hundreds of billions of dollars because of a dramatic reduction in traffic crashes, according to a new study. GPS tracking company Global Positioning Specialists found that the U.S., which loses more money on car crashes than any other country in the world, could save $306 billion a year due to the impacts of autonomous and connected vehicles. The study calculated the percentage of gross domestic product (GDP) lost to all types of road crashes each year and factored in how much of that would likely be reduced by driverless car technology. It's estimated that self-driving cars could cut the 90 percent of crashes caused by human error.