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'Harold & Kumar' Creators Jon Hurwitz and Hayden Schlossberg Still Love to Bake...Christmas Cookies
on November 06, 2011 by Drew Tewksbury
When Jon Hurwitz and Hayden Schlossberg were in high school, they became friends. When they were seniors in college (Hurwitz studied investment banking at Penn, Schlossberg studied law at the University of Chicago), they resolved to switch gears and do something creative. And when they graduated, the two moved to LA where they became roommates, writing partners and hot, young Hollywood commodities when Harold & Kumar Go to White Castle became an unexpected demi-hit. Though they've charmed their way into new projects (like the upcoming Pie sequel American Reunion) they've stuck with the stoner dudes through two more Kumar comedies and have wild ideas for more—Harold and Kumar: Black History Month, anyone?
How old were you guys when you sold your first script?
Jon Hurwitz: We were right out of college. We sold our first script when we were seniors in college. It was a different script called Filthy. We were 21. So then we moved down to LA and were, you know, 22 together in Los Angeles. And our lifestyle was similar to Harold and Kumar's although the difference for us was we both worked at home. And we lived together. We worked together. We would have our long days at work busting our asses to try to solve that next thing. And then at night we would "get hungry" and go out and go on an adventure for burgers.
Oh, I see. "Get hungry." I know what that means. [Editor's note: It's illegal.]
Hayden Schlossberg: We'd "get hungry" quite a bit. Every now and then we still "get hungry."
I would hope so.
Schlossberg: Not as much as we used to...
Sounds like some of your own personal experiences went into this film.
Schlossberg: I think it's our experience watching Christmas movies that comes into our writing. You know, we loved A Christmas Story. Growing up, you'll watch a Christmas movie and there's a warmth that comes out of the movie, whether it's Home Alone or even Christmas Vacation. There's this Christmas energy and vibe that is so warm and fuzzy, and it felt like Harold and Kumar are so outrageous that having them in a Christmas movie would be completely sacrilegious and outrageous.
Hurwitz: That's the area where it does come from true life. It was a very real thing. We found that there are certain people, as you become an adult, who sort of head down a path where you become a "super-adult," and you're really focused on adult things and you lose some of yourself. We always believe in the child within, and I think Harold in this movie has sort of gone a little bit off the rails from a fun standpoint. And Kumar, we have friends who are like Kumar, who are still harping on the same thing they did when they were just getting out of college and haven't progressed and haven't taken adult life seriously and done anything with it. We've seen friendships disappear—people who we used to hang out with who we no longer do. But every time that you end up seeing each other, you find kind of who you were when you were young again.
You guys have been friends for a long time. When did you first come up with these characters of Harold and Kumar?
Schlossberg: While we were in college we decided to write a screenplay, and at the time, there hadn't been a great R-rated youth comedy that had come out. We wanted to write a movie that just had high school or college age characters where they are actually the way those kids are. We had a lot of Asian and Indian friends growing up, and so we made sure in that first screenplay, even though it wasn't a Harold and Kumar movie, to have Asian and Indian side characters, and we actually named them Harold and Kumar: one because we had a friend named Harold at the time and another friend whose brother's name was Kumar. We had sold a couple screenplays but nothing was getting produced, and it just seemed like we wanted to write something that was just different from every other youth comedy that was out there at the time. If we put the spotlight on Harold and Kumar, it'll feel different—we don't need to write it about the Asian-American experience. We can write a movie starring Asian characters that's just about something we'd go through.
Hurwitz: Well, that was the thing. The whole point about Harold and Kumar was that they're no different from us. We were like, "What's a movie that we can write that's personal to us that we think could bring big laughs that no one else in town is writing?" And that's where Harold & Kumar Go to White Castle came from.
Although the movies are comedies, there is an interesting statement about race, ethnicity, and identity. The characters really represent this larger group of first generation Americans from different cultures, who are randomly put together in dormrooms and bond over cheeseburgers and weed.
Hurwitz: We just sort of thought that the Asian and Indian-Korean and Indian—those were the characters that were not being portrayed on the big screen in a way that reflected society, the society that we knew. We thought it would be really fun to pair the two of them, rather than have, you know, a white guy and an Asian guy or black guy and Indian guy. We just figured an Asian guy and an Indian guy are two unrepresented minorities.
Schlossberg: If you look at the schools that we went to, they were so multicultural. When you looked at youth comedies, every high school comedy or college comedy was just a group of white guys. If you look at American Pie, it's all white guys. So it just felt like that's not real. In the world that we grew up in, if you were to have four or five friends, there'd at least be one Indian guy or Asian guy or black guy in the mix—if not in the majority. So it was really just that we saw a disconnect between reality.
The movie is definitely a stoner movie. What are some of your favorites?
Schlossberg: Half Baked is one of my favorite stoner comedies. The Big Lebowski.
Hurwitz: There were no great stoner comedies when we were growing up—
Schlossberg: We didn't set out to be guys who created a stoner franchise, although we did when we wrote Harold & Kumar Go to White Castle. But when we entered screenwriting, it was really, like, we just trying to write movies that would be crowd pleasers. I think that what's fun about Harold and Kumar is there are fewer rules.
What are the hallmarks of a great stoner film?
Hurwitz: Weed. Nudity. Animals. Neil Patrick Harris.
Animals?
Hurwitz: Yeah, animals are usually a part of it.
Schlossberg: The first movie has a cheetah. The second movie has a deer, you know. The third movie has the reindeer. There's all sorts of—
Animal death. Very important. Neil Patrick Harris, how involved was he with writing the movie?
Hurwitz: We write all the Neil stuff, but we collaborate with him. It's one of those things where we'll tell him our ideas, he'll respond to them, we'll write stuff up, we'll send him pages, he'll react to the pages and we'll discuss. It's really just a discussion, but we generally come up with the bulk of the ideas with the stuff with Neil, and he tells us, "Hey, what if we do this?"
Now it's time for the lightning round. I'll give you a holiday, and you give me what would happen in that Harold and Kumar movie. Ready?
Hurwitz: Yeah
Harold & Kumar: Easter Time.
Schlossberg: They would have to hide eggs in a weird place, I think. In an uncomfortable place.
Harold & Kumar: Valentine's Day.
Hurwitz: That's the one where they finally-
Schlossberg: They finally ditch the girlfriends and get real and start making out with each other.
And then finally: Harold & Kumar: Black History Month?
Schlossberg: I think Frederick Douglass gets involved and they all kick ass.
Hurwitz: They just all-they go on a shooting spree.
Schlossberg: It's Frederick Douglass vs. Neil Patrick Harris, like Mothra vs. Godzilla.
Tags: Jon Hurwitz, Hayden Schlossberg, A Very Harold & Kumar Christmas
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Police have arrested a man in connection with a fatal stabbing early Saturday in the east valley.
Police have arrested a man in connection with a fatal stabbing early Saturday near downtown Las Vegas.
Julio Aguero-Alvarez, 34, was arrested Saturday morning, Metro said in a news release.
About 2:30 a.m., police responded to reports of a stabbing in the 300 block of North 16th Street, the release said. Other officers in the nearby area of Bruce Street and Stewart Avenue saw a woman being chased by a man, the release said. The man was detained, and the woman led officers to the location of a man suffering from multiple stab wounds inside a nearby residence. Metro said that two men were arguing over the woman before one stabbed the other, according to the release.
The man was transported to University Medical Center where he later died, the release said. His identity will be released by the Clark County coroner's office.
Aguero-Alvarez is being held in the Clark County Detention Center where he faces a charge of murder with a deadly weapon and attempted murder with a deadly weapon, the release said.
Metro said this is the 35th homicide the department has investigated in 2016. No more details were immediately available.


text:
Beyond Air® Reports Positive Interim Results for LungFit® GO Pilot Study Using High Concentration Inhaled Nitric Oxide Self-Administered, At-Home for Nontuberculous Mycobacterial Lung Disease
XAIR
Beyond Air™
October 20, 2021, 8:00 AM ·8 min read
Interim results show that 250 parts per million (ppm) nitric oxide (NO) was well-tolerated with no study discontinuations or treatment-related serious adverse events observed
At the time of data cutoff, 8 subjects were successfully titrated up to 250 ppm NO with none having titrated down while in the study
LungFit® GO is the first NO generator and delivery system safely used in a clinical trial in the home setting with patients self-administering high concentration NO treatment
GARDEN CITY, N.Y., Oct. 20, 2021 (GLOBE NEWSWIRE) -- Beyond Air, Inc. (NASDAQ: XAIR), a clinical-stage medical device and biopharmaceutical company focused on developing inhaled nitric oxide (NO) for the treatment of patients with respiratory conditions, including serious lung infections and pulmonary hypertension, and gaseous NO (gNO) for the treatment of solid tumors, today announced positive interim data from the ongoing LungFit® GO pilot study in Australia. In this study, patients self-administered high concentration inhaled NO at home to treat severe nontuberculous mycobacterial (NTM) lung disease. The Company expects complete safety and efficacy results to be reported in 2022.
At the time of the data cutoff on September 6, 2021, a total of 8 subjects were enrolled in the pilot study. The mean age of subjects was 56.6 years (range: 22–73 years) with the majority female (87.5%), a distribution consistent with real-world NTM disease, and occurring at a higher rate in older adult women than men1. At baseline some subjects were diagnosed with more than one strain of NTM.
Interim data showed that high concentration inhaled NO was well tolerated with no study discontinuations and no treatment-related serious adverse events. All 8 subjects were successfully titrated to 250 ppm NO in the hospital setting, and none have required dose reductions during the subsequent at-home portion of the study. Methemoglobin and NO2 concentrations remained within acceptable ranges in all subjects during NO treatment, and below the safety thresholds of 10% and 5 ppm, respectively. The study continues to enroll patients, and the totality of the data will be used to evaluate efficacy measures including quality of life, physical function, and sputum bacteria as compared to baseline measurements.
"We believe these data show that safe self-administration of nitric oxide at concentrations up to 250 ppm in the home setting is now a reality. This therapeutic advance was made possible by the Beyond Air engineering team's ability and dedication to produce the LungFit® system. We believe that LungFit® GO will ultimately offer freedom to NTM patients, and others suffering from chronic refractory severe lung infections, by allowing them to self-administer treatment in the comfort of their own homes or anywhere they choose with a standard electric outlet available," said Steve Lisi, Chairman and Chief Executive Officer of Beyond Air. "The Beyond Air team continues to work with our Australian colleagues, who have been outstanding in a difficult COVID-19 lockdown environment, to complete this study. We are encouraged by these interim data and look forward to reporting the complete efficacy and safety results, which are expected to be announced in 2022."
"I am very pleased with the safety profile of 250 ppm NO to date, as this is the highest concentration of inhaled NO that has ever been tested in a clinical trial with patient self-administration in the home. The bactericidal effects of high concentration NO on the Mycobacterium abscessus strain of NTM have been well documented in preclinical in vitro studies, along with its broad-spectrum activity against multiple bacterial and fungal pathogens at 200 ppm NO," commented Andrew Colin, M.D., Batchelor Family Professor of Cystic Fibrosis and Pediatric Pulmonology Director, Division of Pediatric Pulmonology, Miller School of Medicine, University of Miami. "Refractory NTM lung infection is notoriously difficult to treat, and patients often suffer side effects and require complex dosing schedules to complete the 6-to-18-month combination antibiotic regimens that are the current standard of care. Given these new interim safety and tolerability data, with methemoglobin and nitrogen dioxide levels remaining at acceptable levels, the future for the LungFit® GO device is promising. I look forward to the final analyses of the full data set and hope to see results to support a move to a larger, definitive study in NTM patients. If successful, such a study could prove transformative for the lives of NTM patients."
1 Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration (FDA). The Voice of the Patient. Non-Tuberculous Mycobacterial (NTM) Lung Infection. Public Meeting: October 15, 2015. Report Date: April, 2016. accessed 10/4/2021 at http://www.fda.gov/downloads/ForIndustry/UserFees/PrescriptionDrugUserFee/UCM496941.pdf
LungFit® GO NTM Trial Design
The 12-week, multi-center, open-label clinical trial is taking place in Australia and will enroll approximately 20 adult subjects with chronic refractory NTM lung disease. The trial is enrolling both cystic fibrosis (CF) and non-CF subjects chronically infected with Mycobacterium avium complex (MAC), Mycobacterium abscessus complex (MABSC) or other strains of NTM. The trial consists of a run-in period followed by two treatment phases. The run-in period provides a baseline for the efficacy endpoints, such as patient physical function and bacterial load. The first treatment phase takes place over a two-week period and begins in the hospital setting where subjects are titrated from 150 ppm NO up to 250 ppm NO over several days. During this first treatment phase subjects receive NO for 40 minutes, four times per day while methemoglobin and nitrogen dioxide (NO2) levels are monitored. Subjects are trained to use LungFit® GO and subsequently discharged to complete the remaining portion of this two-week treatment period at their home administering the highest tolerated NO concentration. For the second treatment phase, a 10-week maintenance phase, the inhalation treatments are administered twice daily. The study evaluates safety, quality of life, physical function, and bacterial load among other parameters, as compared to baseline measurements.
About Beyond Air, Inc.
Beyond Air, Inc. is a clinical-stage medical device and biopharmaceutical company developing a revolutionary NO Generator and Delivery System, LungFit®, that uses NO generated from ambient air to deliver precise amounts of NO to the lungs for the potential treatment of a variety of pulmonary diseases. The LungFit® can generate up to 400 ppm of NO, for delivery either continuously or for a fixed amount of time and has the ability to either titrate dose on demand or maintain a constant dose. The Company is currently applying its therapeutic expertise to develop treatments for pulmonary hypertension in various settings, in addition to treatments for respiratory tract infections that are not effectively addressed with current standards of care. Beyond Air is currently advancing its revolutionary LungFit® for clinical trials for the treatment of severe lung infections such as acute viral pneumonia (including COVID-19) and nontuberculous mycobacteria (NTM). Additionally, Beyond Air is using ultra-high concentrations of NO with a proprietary delivery system to target certain solid tumors in the pre-clinical setting. For more information, visit www.beyondair.net.
About the LungFit®*
Beyond Air's is a portable device that weighs only 20 lbs. and operates with a standard electrical outlet (120-240 volts). Since NO is generated from ambient air that flows through a reaction chamber, there is an unlimited supply. Beyond Air's proprietary nitrogen dioxide (NO2) filters are required for the system to generate and safely deliver NO. Toxic levels of NO2 can result from high concentrations of NO without proper filtration. The filters also program the system, via an attached RFID chip, with respect to NO concentration, flow rate and duration of therapy. The Company believes this design provides maximum flexibility for NO administration. Filters are single patient use and there are no special requirements for disposal. Alarms monitor system performance.
* Beyond Air's LungFit® is not approved for commercial use. Beyond Air's LungFit® is for investigational use only.
About Nitric Oxide (NO)
Nitric Oxide (NO) is a powerful molecule, naturally synthesized in the human body, proven to play a critical role in a broad array of biological functions. In the airways, NO targets the vascular smooth muscle cells that surround the small resistance arteries in the lungs. Currently, exogenous inhaled NO is used in adult respiratory distress syndrome, post certain cardiac surgeries, and persistent pulmonary hypertension of the newborn to treat hypoxemia. Additionally, NO is believed to play a key role in the innate immune system and in vitro studies suggest that NO possesses antimicrobial activity not only against common gram-positive and gram-negative bacteria, but also against other diverse pathogens, including mycobacteria, viruses, fungi, yeast and parasites, and has the potential to eliminate multi-drug resistant strains.
Nontuberculous mycobacteria (NTM) infection is a rare and serious bacterial infection in the lungs causing debilitating pulmonary disease associated with high morbidity and mortality. NTM infection is acquired by inhaling aerosolized bacteria from the environment, and can lead to NTM lung disease, a progressive and chronic condition. According to the Cystic Fibrosis Foundation, 13% of U.S. cystic fibrosis patients had a positive culture for a NTM species in 2017. NTM is an emerging public health concern worldwide because of its multi-drug antibiotic resistance. Current treatment guidelines suggest a combination of multiple antibiotics dosed chronically for as long as two years. These complex, expensive and invasive regimens have a poor record in the treatment of Mycobacterium abscessus complex (MABSC) and refractory Mycobacterium avium complex (MAC) and have the potential to cause severe adverse events. Beyond Air's system is designed to deliver 150 - 400 ppm NO to the lung, and early data indicate that this range of NO concentrations could have a positive effect on patients infected with NTM.
This press release contains "forward-looking statements" concerning inhaled nitric-oxide and the Company's LungFit®† product, including statements with regard to potential regulatory developments, the potential impact on patients and anticipated benefits associated with its use. Forward-looking statements include statements about our expectations, beliefs, or intentions regarding our product offerings, business, financial condition, results of operations, strategies or prospects. You can identify such forward-looking statements by the words "anticipates," "expects," "intends," "impacts," "plans," "projects," "believes," "estimates," "likely," "goal," "assumes," "targets" and similar expressions and/or the use of future tense or conditional constructions (such as "will," "may," "could," "should" and the like) and by the fact that these statements do not relate strictly to historical or current matters. Rather, forward-looking statements relate to anticipated or expected events, activities, trends or results as of the date they are made. Because forward-looking statements relate to matters that have not yet occurred, these statements are inherently subject to risks and uncertainties that could cause our actual results to differ materially from any future results expressed or implied by the forward-looking statements. These forward-looking statements are only predictions and reflect our views as of the date they are made with respect to future events and financial performance. Many factors could cause our actual activities or results to differ materially from the activities and results anticipated in forward-looking statements, including risks related to: our approach to discover and develop novel drugs, which is unproven and may never lead to efficacious or marketable products; our ability to fund and the results of further pre-clinical and clinical trials; obtaining, maintaining and protecting intellectual property utilized by our products; our ability to enforce our patents against infringers and to defend our patent portfolio against challenges from third parties; our ability to obtain additional funding to support our business activities; our dependence on third parties for development, manufacture, marketing, sales, and distribution of products; the successful development of our product candidates, all of which are in early stages of development; obtaining regulatory approval for products; competition from others using technology similar to ours and others developing products for similar uses; our dependence on collaborators; our short operating history and other risks identified and described in more detail in the "Risk Factors" section of the Company's most recent Annual Report on Form 10-K and other filings with the SEC, all of which are available on our website. We undertake no obligation to update, and we do not have a policy of updating or revising, these forward-looking statements, except as required by applicable law.
Maria Yonkoski, Head of Investor Relations
Beyond Air, Inc.
Myonkoski@beyondair.net
Corey Davis, Ph.D.
LifeSci Advisors, LLC
Cdavis@lifesciadvisors.com

redpajama_set_name: RedPajamaCommonCrawl


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gst-launch -e videotestsrc pattern="snow" ! video/x-raw-yuv, framerate=10/1, width=200, height=150 ! videomixer name=mix !
According to the online documentation the position and Z-order can be adjusted using the GstVideoMixerPad properties; however, I do not yet know how to use this.
gst-launch -e videotestsrc pattern="snow" ! video/x-raw-yuv, framerate=10/1, width=200, height=150 ! videobox border-alpha=0 top=-20 left=-25 !
Note that the "top" and "left" values are negative, which means that pixels will be added to the incoming stream. Positive value means that pixels are cropped from the incoming stream. If we'd made "border-alpha" equal 1.0 we'd seen a black border on the top and the left of the child image extending to the edges of the window.
gst-launch -e videotestsrc pattern="snow" ! video/x-raw-yuv, framerate=10/1, width=200, height=150 !
This was easy, wasn't it?
videobox border-alpha=1.0 top=-2 bottom=-2 left=-2 right=-2 ! videobox border-alpha=0 alpha=0.6 top=-20 left=-25 !
We are now ready to move on to a more complex example.
videotestsrc pattern=0 ! video/x-raw-yuv, framerate=1/1, width=350, height=250 !
textoverlay font-desc="Sans 24" text="CAM1" valign=top halign=left shaded-background=true !
videobox border-alpha=0 top=-200 left=-50 ! mix.
videotestsrc pattern="snow" ! video/x-raw-yuv, framerate=1/1, width=350, height=250 !
textoverlay font-desc="Sans 24" text="CAM2" valign=top halign=left shaded-background=true !
videobox border-alpha=0 top=-200 left=-450 ! mix.
videotestsrc pattern=13 ! video/x-raw-yuv, framerate=1/1, width=350, height=250 !
textoverlay font-desc="Sans 24" text="CAM3" valign=top halign=left shaded-background=true !
videobox border-alpha=0 top=-200 left=-850 ! mix.
multifilesrc location="pluto.jpg" caps="image/jpeg,framerate=1/1" ! jpegdec !
textoverlay font-desc="Sans 26" text="Live from Pluto" halign=left shaded-background=true auto-resize=false !
ffmpegcolorspace ! video/x-raw-yuv,format=(fourcc)AYUV ! mix.
For the large background image, which is a still frame I wanted to use the "imagefreeze" block which generates a video stream from a single image file. Unfortunately, it seems that this block is very new and not in the gstreamer package that comes with Ubuntu 10.04. Thereofre, I had to do the trick with "multifilesrc" making it read the same file over and over again.
I had a hard time getting this pipeline work. Eventually I found out that my problems were due to incompatible caps in the miltifilesrc part of the pipeline. That's why there is an extra color conversion block between the textoverlay and the videomixer.
The videobox elements are used to add a transparent border to the small video feed causing the real video to be moved according to the pixels specified for the "top" and "left" parameters. I have later learned that it can be accomplished without using videobox, see my Gstreamer cheat sheet.
The frame rate is set to 1 fps because I have been doing this on a slow computer. You should feel free to experiment with higher frame rates if you are sitting at a faster computer.
videotestsrc pattern=1 ! video/x-raw-yuv,framerate=5/1,width=320,height=180 ! videobox border-alpha=0 top=0 left=0 ! mix.
videotestsrc pattern=15 ! video/x-raw-yuv,framerate=5/1,width=320,height=180 ! videobox border-alpha=0 top=0 left=-320 ! mix.
videotestsrc pattern=13 ! video/x-raw-yuv,framerate=5/1,width=320,height=180 ! videobox border-alpha=0 top=-180 left=0 ! mix.
videotestsrc pattern=0 ! video/x-raw-yuv,framerate=5/1,width=320,height=180 ! videobox border-alpha=0 top=-180 left=-320 ! mix.
videotestsrc pattern=3 ! video/x-raw-yuv,framerate=5/1,width=640,height=360 ! mix.
Be sure to check out my Gstreamer cheat sheet which is a continuously updated wiki page and feel free to leave a comment if you have other tips and tricks.


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