text:
Václav Havel: Outtakes from an Interview
By Adam Thirlwell
My first memory of Václav Havel is of watching the news as a kid, after the Hanna-Barbera cartoons, and seeing pictures of Havel in his living room: a prison of stuffed bookshelves. For me, Havel was the image of a literary hero, an ideal of literature as integrity.
I've always, in other words, been a sucker for the questions of Prague—especially Prague in the era of Soviet Communism, probably because these questions all relate to a larger problem: a writer's responsibility and resistance to political life, the serious business of being flippant. In the setups of his farcical plays and—following his imprisonment in 1977 for involvement in a human-rights charter—through the patient linguistic analysis of his essays, Havel's subject was always the same: how language can be made to connive in unreality. But he also believed that words could be renovated, that a politics was possible. And this hope led him, for instance, to the courage of the following statement in his 1977 trial: there were certain words, he said, "which recur continually in the indictment and which one would describe as loaded, words like subversion, lies, malice, illegal organizations, anticommunist centers, vilification, hatred and so on. However, when one looks closely at these words, one finds that there is nothing behind them." Just as it made him read Bellow's libertine Herzog, in prison, in these dissident terms: "A professional with 'words' goes mad in a situation where words have no weight. He clearly lacks what we do not, which is to say a situation in which words have so much weight that you must pay quite dearly for them."
This was why, in the summer of 2010, I found myself proposing a Paris Review interview to Havel. I wanted to ask him my own series of Prague questions, about his love of Bohumil Hrabal's stories, the cinema of the Czech New Wave, his intuition of farce … These questions, basically, were one big question: What was it like for a writer, as he did, to end up in the Presidential Palace?
The Interview, however, turned into a melancholy comedy of its own.
When we met, in November 2010, Havel was seventy-four, and in the middle of postproduction on his first movie: an adaptation of his last play, Leaving, which was first put on in Prague in 2008, five years after he'd left the presidency of the Czech Republic. The play tells the story of Vilem Rieger, a former chancellor of an unnamed country, who must either support the new regime of his previous deputy or be forced from his state-owned villa.
Havel was neatly dressed in a black turtleneck and a black corduroy jacket. He looked, I thought, sometimes like William H. Macy and sometimes like Asterix. He was magnificently small. His offices were around the corner from the Café Slavia and the National Theater. They were kept tropically warm: for Havel, who had already had one lung removed, lived in constant danger of respiratory problems. On the walls, there were photos of Havel with Obama, with the Prince and Princess of Wales, with the former Pope. There was a kind of rich, jazzy, sixties style to the furniture: angles and leather, black and red.
But as the conversation proceeded it became clear that my ideal dialogue would have to wait. Havel's exhausting work on his film meant that, for the moment, he could only offer me forty minutes. Time, therefore, was the first problem. The second was language. I asked my questions in English, then Havel replied in Czech—very quickly, and very softly—and then his translator translated. Which is another way that language connives in unreality.
The film of Leaving premiered around four months later, in March of this year. Earlier that month, Havel had been hospitalized following an inflammation of the lungs. After the premiere, his personal assistant politely wrote saying that they had indefinitely cleared Havel's schedule.
When I heard with sadness this weekend that Havel had died, I considered our transcript. It was so sketchy that it felt more like a bootleg tape. But, then again, maybe that was right. Because, famously, Havel's Prague Revolution was also American, a revolution in love with the New York counterculture. And after all, the last thing that I'd talked about with this hero of the Velvet Revolution was his love of the Velvet Underground.
You began your most recent play, Leaving, before the Revolution of 1989. Could you describe the process of this play's composition?
Before the 1989 Revolution, I had an idea for a character like King Lear, who loses power, and then the world starts to disintegrate. It might have been the influence of the generation of 1968—the people who had been party members, who had professional careers. And then all of a sudden after '68 they were thrown out and started to live ordinary lives, and they pretended that they didn't mind, but in fact they did. I was also trying to make certain references to other works. There's a certain hint of King Lear, a certain hint of Chekhov's The Cherry Orchard, a certain hint of Samuel Beckett. Mostly they were just references for myself.
There are also many moments when you quote from your own essays. In one essay you say that man should be at the center of politics. This phrase gets repeated, sarcastically, in your play. It's almost as if you're writing the play against yourself.
I think it's important for one to take a certain distance from oneself. I've always tried to see the absurdity of my own dealings, my own acts—and I think that this is reflected not just in the plays but in my civic life as well. I always noticed, even in my dissident life, the comical moments.
In your work there's a very porous boundary between the absurd and the political. In your 2007 memoir To The Castle and Back, you suddenly use the term "Ptydepe," the nonsense language you invented in your 1965 play The Memorandum, to describe the language of European Union communiqués. And I wonder if there's something specifically Prague about this—in showing the gap between a word and its meaning. Are there other Central European writers who influenced you?
I like Hašek, with his very original and very specific sense of humor. And Ionesco really influenced me in my youth in the late fifties, together with Beckett and Genet. But if I were to say who influenced me most, then I'd say Franz Kafka. And his works were always anchored in the Central European region. About twenty years ago, I was awarded an honorary degree at the University of Jerusalem where I gave a speech called "Franz Kafka and my Presidency." I basically said that if Franz Kafka hadn't written his works, then I would have had to do it for him. Which sounds a bit vain, but I think people understood what I meant.
I remember that in the fifties you also wrote one of the earliest essays on Bohumil Hrabal.
I was one of the first people, maybe the first person, to write about his work. It was published in one of those samizdat pamphlets. I was very young then, about twenty, and people noticed this particular piece. He wasn't published then. He was working in some waste-collection point, where he was sorting rubbish. The first texts by Hrabal were absolutely breathtaking, like Jarmilka. It was a very short novel—it was rough, it was almost surreal, it was mysterious, it had a very tense note to it. Later, in the sixties, Hrabal started to be published—and his texts were smoother, more polished, cleaner, which resulted from the fact that, unfortunately, he listened to his editors.
Why did you decide to make Leaving into a film?
Originally, it wasn't my idea to make a film. A Czech director thought of it. But then I decided I could do it myself. I'd always had so many other people interpreting my texts and putting them in movies.
Did Jan Němec and his generation of filmmakers—like Jiří Menzel, and Miloš Forman—influence you?
We were the first generation unstained by the conflict of Communism or anti-Communism: we were still young in the postwar years, in February 1948. We were friends, and even though we were all studying something different, we were close. We shared the same experience: a non-ideological experience. We were a non-ideological generation.
But how far do you think a style can be non-ideological? There's a famous anecdote of Forman in Cannes in May 1968. He was there to show his movie The Fireman's Ball, which had only just gotten past the Communist censors. But Godard and Truffaut, in support of the students in Paris, had stopped the whole festival. They were shouting Communist slogans, in favor of the workers. And Forman, in the end, because he loved their films so much, allowed his film to be withdrawn in solidarity. It's such a strange illustration of the way ideology was fluid, how the experiences of Paris and Prague in 1968 were fundamentally misaligned.
I think it depends on how we define ideological. If we see it as a set of opinions that are fixed, stationary, closed, that have no room for curiosity, that are omnipresent and omniscient—in this sense, we were a non-ideological generation. As opposed to some older friends who could be called left wing, or could be called former Communists, we didn't start with a dogmatic ideology. That's the difference between the two generations.
There's a moment in Disturbing the Peace where you say that every member of the audience must find a play out for themselves. You've always separated this writing from your political essays—but is there a way in which your theory of the audience is also a theory of a citizen in a democracy, of someone who interprets and takes part in a dialogue?
In my opinion, theater shouldn't give advice to citizens. Theater is there to search for questions. It doesn't give you instructions. I always fought for a more humble position in life. For the small, the mysterious: something that can't be summed up in four words. How each citizen takes on his citizenship is very individual. And I think that theater is there to create a certain atmosphere of togetherness. I think people are there to ask themselves questions, as a community.


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'Tis the season to be out of reading material.
I work in a bookstore, so I get fairly decent deals off of books, and as a result, I read more than a little. For classes, I, of course, have to, but I mean for pleasure.
And I'm looking for suggestions. Good books are my aim, but some people thought Twilight was good, so I'll give you some pointers so that you don't make such grave mistakes.
I mostly like fantasy, science fiction, and historical fiction. Essentially, adventure books. However, my favourite books tend to be things like Wicked (or rather, the sequel), Life of Pi, Watership Down and, best book of all time, Fantastic Mr. Fox (so awesome).
Any suggestions, preferably along the whole "epic fantasy/historical fiction" route?
As you can see, it's kinda heavily leaning towards epic fantasy series, so if you've got a good one, sing it out. Obviously, I've read more than this, but reccomend away. I'll tell you what I have an haven't read, and tell you my various and varying opinions on them.
I used to have a whole bunch of titles, I think. That probably makes me better than you. Maybe.
If you like epic fantasy, then all I can do is recommend George R. R. Martin.
Koontz is someone I'm looking into. He's frankenstein series is very tempting. I think I'ma get into that over christmas.
Which grisham would you recommend, if you could only recommend one?
I've ready ALOT of fantasy. Perhaps a more exauhstive list is required.
Also, there's no point in reading Martin. he's never going to finish the series, since he writes one book EVERY UMPTEEN YEARS!! I mean, dammit, how long has it been since Feast for Crows came out? 2005? That's minimum four years ago, possibly FIVE. And we have no idea when it`s coming out. If it was coming out in 2010, we`d know. The earliest is therefore 2011.
Anyways, other awesome fantasy that I`ve read are (including the above list) and by author rather than series.
I can't think of any other important/age appropriate ones. there may be. Keep the suggestions coming! I know you all read fantasy!
Please don`t suggest Goodkind, I think he's terrible.
If you haven't read Feist's Krondor novels, you should.
I've read some of them, but not all.
I read the Betrayal of Krondor, which is one of the first ones, quite a long time ago. More recently I read his trilogy about Talon of the Silver Hawk. Twas alright, but not really that impressive. Any specific books you recommend?
Add Elizabeth Moon's "The Deed of Paksenarrion" to your list. You won't regret it.
Read Magician. It's a large book, usually sold in two volumes now (Apprentice and Master). Get the Author's Preferred Edition, if you can find it.
The whole Riftwar Saga is pretty good, actually.
Thanks. I'll check 'em out.
Boy's Life by Robert McCammon. It was recommended to me by a co-worker a couple weeks ago. I read it and loved it.
here are some suggestions for ya!
ive read them all. thats all i can think of at the moment oh and also there was a trilogy i think the first book was assassins apprentice.
I have been reading all of R.A. Salvator's books. All the ones in reference to Drizzt the Dark Elf.
gonna google to see which ones tho.


text:
Q: When was the last time Anakin fought Dooku prior to RotS? I thought this was asked before so I tried to find the question, but couldn't find it so I apologize if this has an answer already.
Anyways, Anakin said to Dooku:

"My powers have doubled since the last time we fought Count"

Using canon, when was the last time they actually fought? Was Episode two the last time?

A: CANON: Anakin fought Dooku last in The Clone Wars season 6 episode 10 "The Lost One".

Anakin and Obi-Wan engage Dooku in combat where they learn that the man called Tyranus is really Count Dooku. Because of this, the Council deduces that Dooku was responsible for the creation of the army. Questioning why their enemy created them an army, Yoda explains that this was really the work of the Dark Lord of the Sith and that all they could do is "play his game".
- source

In case of confusion: the fight between Anakin and Dooku that occurred in season 6 episode 13 "Sacrifice" was actually a just dream-like vision or illusion that happened in Yoda's mind.

A: In Dark Disciple, a canon book based on unfinished episodes of Star Wars: The Clone Wars, Anakin and Dooku fight while Obi-Wan

 is with Ventress saving Quinlan Vos.

According to the official chronology on starwars.com, this is set after season six. From what we know, this is the last time they fought before Star Wars Episode III: Revenge of the Sith. Funnily enough, this was pretty far into the last year of the war, so it didn't take Anakin long to double his powers.

redpajama_set_name: RedPajamaStackExchange


A former militia leader from the Central African Republic known as "Colonel Rambo" was tortured in detention before his transfer to The Hague on war crimes charges, his lawyer said Friday.
The arrest of Alfred Yekatom, who made his first appearance at the International Criminal Court since his extradition, was "brutal" and he was later beaten with rifle butts, his defence said.
Yekatom, 43, was arrested in October in Bangui and sent on Saturday to the Netherlands for his role in bloody unrest in the CAR pitting Christian and Muslim groups against each other since 2013.
"The arrest was, according to him, brutal," lawyer Xavier-Jean Keita told the court.
He faces 14 charges of war crimes and crimes against humanity including murder, mutilation, torture, cruel treatment and recruiting child soldiers into his so-called anti-Balaka militia group.
"No one said anything to me, I was at parliament and there was a bit of trouble there. Then they arrested me and sent me here," the ex-fighter, wearing a suit and listening to a translation of the proceedings on headphones, told the court.
The court will hold an official hearing to confirm the charges on April 30 2019, Judge Antoine Kesia-Mbe Mindua said.
"You have raised a very important problem and we cannot deal with it orally. We have to have written submissions, at this stage we cannot discuss this question, nor resolve it."
The arrest warrant said the shooting incident in parliament showed "that he resorts to violent acts" and that his arrest was necessary "to prevent him from committing further crimes within the jurisdiction of the court."


text:
Professor, School of Kinesiology, Faculty of Education, University of British Columbia
Professor, Faculty of Land and Food Systems, University of British Columbia
Exercise and Physical Fitness
David.Wright@bcchr.ca
V5Z 4H4
My laboratory is interested in understanding the impact, and underlying mechanisms, of exercise, nutrition and pharmaceutical interventions on fat tissue (adipose) and the liver and in turn how this influences how the body utilizes and stores fat and carbohydrate. A particular area of emphasis over the past few years has been examining the metabolic side effects of antipsychotic medications, a class of drugs that are prescribed to individuals with schizophrenia. In this area of research, we have been attempting to identify the utility of lifestyle approaches, i.e. diet and exercise, to offset weight gain and hyperglycemia caused by antipsychotic medications.
Intermittent cold exposure improves glucose homeostasis despite exacerbating diet-induced obesity in mice housed at thermoneutrality
McKie, G.L. and Shamshoum, H. and Hunt, K.L. and Thorpe, H.H.A. and Dibe, H.A. and Khokhar, J.Y. and Doucette, C.A. and Wright, D.C.
DOI: 10.1113/JP281774
Topical application of the pharmacological cold mimetic menthol stimulates brown adipose tissue thermogenesis through a TRPM8, UCP1, and norepinephrine dependent mechanism in mice housed at thermoneutrality
FASEB Journal
McKie, G.L. and Medak, K.D. and Shamshoum, H. and Wright, D.C.
DOI: 10.1096/fj.202101905RR
CHOP is dispensable for exercise-induced increases in GDF15
Townsend, L.K. and Medak, K. and Weber, A.J. and Dibe, H. and Shamshoum, H. and Wright, D.C.
DOI: 10.1152/japplphysiol.00698.2021
Plant and marine N3-PUFA regulation of fatty acid trafficking along the adipose tissue-liver axis varies according to nutritional state
Rajna, A. and Brown, L.H. and Frangos, S.M. and Gonzalez-Soto, M. and Hucik, B. and Wang, C. and Wright, D.C. and Mutch, D.M.
DOI: 10.1016/j.jnutbio.2022.108940
An increase in serial sarcomere number induced via weighted downhill running improves work loop performance in the rat soleus
bioRxiv
Hinks, A. and Jacob, K. and Mashouri, P. and Medak, K.D. and Franchi, M.V. and Wright, D.C. and Brown, S.H.M. and Power, G.A.
DOI: 10.1101/2022.02.18.481073
The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued by cilostamide
Physiological Reports
Medak, K.D. and McKie, G.L. and Shamshoum, H. and Seguin, I. and Wright, D.C.
DOI: 10.14814/phy2.15187
New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk
Townsend, L.K. and Macpherson, R.E.K. and Wright, D.C.
DOI: 10.1210/clinem/dgab333
AMPK mediates energetic stress-induced liver GDF15
Townsend, L.K. and Weber, A.J. and Day, E.A. and Shamshoum, H. and Shaw, S.J. and Perry, C.G.R. and Kemp, B.E. and Steinberg, G.R. and Wright, D.C.
DOI: 10.1096/fj.202000954R
Peripheral mechanisms of acute olanzapine induced metabolic dysfunction: A review of in vivo models and treatment approaches
Behavioural Brain Research
Shamshoum, H. and Medak, K.D. and Wright, D.C.
DOI: 10.1016/j.bbr.2020.113049
Voluntary physical activity protects against olanzapine-induced hyperglycemia
Shamshoum, H. and McKie, G.L. and Medak, K.D. and Ashworth, K.E. and Kemp, B.E. and Wright, D.C.
The confounding effects of sub-thermoneutral housing temperatures on aerobic exercise-induced adaptations in mouse subcutaneous white adipose tissue
Biology Letters
McKie, G.L. and Wright, D.C.
DOI: 10.1098/rsbl.2021.0171
Adipose tissue (adipokinome), skeletal muscle (myokinome), and liver (hepatokinome) as endocrine regulators during exercise
The Routledge Handbook on Biochemistry of Exercise
Townsend, L.K. and McKie, G.L. and Shamshoum, H. and Wright, D.C.
Reactive oxygen species-dependent regulation of pyruvate dehydrogenase kinase-4 in white adipose tissue
American journal of physiology. Cell physiology
Townsend, L.K. and Weber, A.J. and Barbeau, P.-A. and Holloway, G.P. and Wright, D.C.
DOI: 10.1152/ajpcell.00313.2019
Cardiac CapZ regulation during acute exercise
Laskary, A. and Townsend, L.K. and Wright, D. and Pyle, W.G.
Recent advances in the role of interleukin-6 in health and disease
Current Opinion in Pharmacology
Peppler, W.T. and Townsend, L.K. and Wright, D.C.
DOI: 10.1016/j.coph.2020.04.010
Epinephrine responsiveness is reduced in livers from trained mice
Dibe, H.A. and Townsend, L.K. and McKie, G.L. and Wright, D.C.
Exercise and Dairy Protein have Distinct Effects on Indices of Liver and Systemic Lipid Metabolism
Townsend, L.K. and Gandhi, S. and Shamshoum, H. and Trottier, S.K. and Mutch, D.M. and Reimer, R.A. and Shearer, J. and LeBlanc, P.J. and Wright, D.C.
DOI: 10.1002/oby.22621
Biochemical adaptations in white adipose tissue following aerobic exercise: From mitochondrial biogenesis to browning
DOI: 10.1042/BCJ20190466
GLP1 receptor agonism protects against acute olanzapine-induced hyperglycemia
American Journal of Physiology - Endocrinology and Metabolism
Medak, K.D. and Shamshoum, H. and Peppler, W.T. and Wright, D.C.
DOI: 10.1152/AJPENDO.00309.2020
Effect of acute high-intensity interval exercise on whole-body fat oxidation and subcutaneous adipose tissue cell signaling in overweight women
International Journal of Exercise Science
Islam, H. and Smith, M.M.W. and Scribbans, T.D. and McCrady, E. and Castellani, L.N. and Allen, M.D. and Wright, D.C. and Simpson, C.A. and Gurd, B.J.
Looking on the "brite" side exercise-induced browning of white adipose tissue
Pflugers Archiv European Journal of Physiology
Townsend, L.K. and Wright, D.C.
Loss of glucagon signaling alters white adipose tissue browning
Townsend, L.K. and Medak, K.D. and Knuth, C.M. and Peppler, W.T. and Charron, J. and Wright, D.C.
Acute administration of IL-6 improves indices of hepatic glucose and insulin homeostasis in lean and obese mice
American Journal of Physiology - Gastrointestinal and Liver Physiology
Peppler, W.T. and Townsend, L.K. and Meers, G.M. and Panasevich, M.R. and Macpherson, R.E.K. and Rector, R.S. and Wright, D.C.
DOI: 10.1152/ajpgi.00097.2018
Female mice are protected against acute olanzapine-induced hyperglycemia
Psychoneuroendocrinology
Medak, K.D. and Townsend, L.K. and Hahn, M.K. and Wright, D.C.
DOI: 10.1016/j.psyneuen.2019.104413
Distinct Gut Microbiota and Serum Metabolites in Response to Weight Loss Induced by Either Dairy or Exercise in a Rodent Model of Obesity
Mayengbam, S. and Mickiewicz, B. and Trottier, S.K. and Mu, C. and Wright, D.C. and Reimer, R.A. and Vogel, H.J. and Shearer, J.
DOI: 10.1021/acs.jproteome.9b00304
Housing temperature affects the acute and chronic metabolic adaptations to exercise in mice
McKie, G.L. and Medak, K.D. and Knuth, C.M. and Shamshoum, H. and Townsend, L.K. and Peppler, W.T. and Wright, D.C.
A blend of fatty acids, organic acids, and phytochemicals induced changes in intestinal morphology and inflammatory gene expression in coccidiosis-vaccinated broiler chickens
Poultry Science
McKnight, L.L. and Peppler, W. and Wright, D.C. and Page, G. and Han, Y.
DOI: 10.3382/ps/pez241
AMPK ß1 activation suppresses antipsychotic-induced hyperglycemia in mice
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shamshoum, H. and Medak, K.D. and Townsend, L.K. and Ashworth, K.E. and Bush, N.D. and Hahn, M.K. and Kemp, B.E. and Wright, D.C.
High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress
Journal of Lipid Research
Townsend, L.K. and Medak, K.D. and Peppler, W.T. and Meers, G.M. and Scott Rector, R. and LeBlanc, P.J. and Wright, D.C.
DOI: 10.1194/jlr.M092510
Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation
Frendo-Cumbo, S. and Jaldin-Fincati, J.R. and Coyaud, E. and Laurent, E.M.N. and Townsend, L.K. and Tan, J.M.J. and Xavier, R.J. and Pillon, N.J. and Raught, B. and Wright, D.C. and Brumell, J.H. and Klip, A.
Regulation of Hepatic Follistatin Expression at Rest and during Exercise in Mice
Medicine and Science in Sports and Exercise
Peppler, W.T. and Castellani, L.N. and Root-Mccaig, J. and Townsend, L.K. and Sutton, C.D. and Frendo-Cumbo, S. and Medak, K.D. and Macpherson, R.E.K. and Charron, M.J. and Wright, D.C.
DOI: 10.1249/MSS.0000000000001893
Exercise Protects Against Olanzapine-Induced Hyperglycemia in Male C57BL/6J Mice
Castellani, L.N. and Peppler, W.T. and Miotto, P.M. and Bush, N. and Wright, D.C.
DOI: 10.1038/s41598-018-19260-x
Subcutaneous inguinal white adipose tissue is responsive to, but dispensable for, the metabolic health benefits of exercise
Peppler, W.T. and Townsend, L.K. and Knuth, C.M. and Foster, M.T. and Wright, D.C.
Obesity exacerbates the acute metabolic side effects of olanzapine
Townsend, L.K. and Peppler, W.T. and Bush, N.D. and Wright, D.C.
DOI: 10.1016/j.psyneuen.2017.12.004
Rosiglitazone is superior to resveratrol in inducing the expression of glyceroneogenic genes in adipose tissue from obese participants
Applied Physiology, Nutrition and Metabolism
Beaudoin, M.-S. and Gaudio, N. and Reed, J.K. and Foute-Nelong, J. and Mutch, D.M. and Wright, D.C.
DOI: 10.1139/apnm-2017-0606
Dietary mannoheptulose does not alter glucose or lipid metabolism in adult Labrador Retrievers
Journal of Animal Physiology and Animal Nutrition
McKnight, L.L. and France, J. and Wright, D. and Davenport, G. and Shoveller, A.K.
DOI: 10.1111/jpn.12713
AICAR prevents acute olanzapine-induced disturbances in glucose homeostasis
Bush, N.D. and Townsend, L.K. and Wright, D.C.
DOI: 10.1124/jpet.118.248393
Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis
Knuth, C.M. and Peppler, W.T. and Townsend, L.K. and Miotto, P.M. and Gudiksen, A. and Wright, D.C.
Estradiol does not directly regulate adipose lipolysis
MacDonald, T.L. and MacPherson, R. and Castellani, L. and Cervone, D. and Anderson, E. and Wright, D.C. and Dyck, D.J.
Alcohol extract of North American ginseng (Panax quinquefolius) reduces fatty liver, dyslipidemia, and other complications of metabolic syndrome in a mouse model
Canadian Journal of Physiology and Pharmacology
Singh, R.K. and Lui, E. and Wright, D. and Taylor, A. and Bakovic, M.
DOI: 10.1139/cjpp-2016-0510
Dairy Attenuates Weight Gain to a Similar Extent as Exercise in Rats Fed a High-Fat, High-Sugar Diet
Trottier, S.K. and MacPherson, R.E.K. and Knuth, C.M. and Townsend, L.K. and Peppler, W.T. and Mikhaeil, J.S. and Leveille, C.F. and LeBlanc, P.J. and Shearer, J. and Reimer, R.A. and Wright, D.C.
Central-Acting therapeutics alleviate respiratory weakness caused by heart failure-induced ventilatory overdrive
Science Translational Medicine
Foster, A.J. and Platt, M.J. and Huber, J.S. and Eadie, A.L. and Arkell, A.M. and Romanova, N. and Wright, D.C. and Gillis, T.E. and Murrant, C.L. and Brunt, K.R. and Simpson, J.A.
DOI: 10.1126/scitranslmed.aag1303
Glucagon receptor knockout mice are protected against acute olanzapine-induced hyperglycemia
Castellani, L.N. and Peppler, W.T. and Sutton, C.D. and Whitfield, J. and Charron, M.J. and Wright, D.C.
Microbiome and NAFLD: Potential influence of aerobic fitness and lifestyle modification
Physiological Genomics
Panasevich, M.R. and Peppler, W.T. and Oerther, D.B. and Wright, D.C. and Rector, R.S.
DOI: 10.1152/physiolgenomics.00012.2017
Cycling our way to fit fat
Townsend, L.K. and Knuth, C.M. and Wright, D.C.
Proliferative endocrine effects of adipose tissue from obese animals on MCF7 cells are ameliorated by resveratrol supplementation
Theriau, C.F. and Sauv{\'e}, O.S. and Beaudoin, M.-S. and Wright, D.C. and Connor, M.K.
Reduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes
American Journal of Physiology - Cell Physiology
Dragos, S.M. and Bergeron, K.F. and Desmarais, F. and Suitor, K. and Wright, D.C. and Mounier, C. and Mutch, D.M.
CL 316, 243 mediated reductions in blood glucose are enhanced in RIP140-/- mice independent of alterations in lipolysis
Biochemical and Biophysical Research Communications
Peppler, W.T. and Miotto, P.M. and Holloway, G.P. and Wright, D.C.
DOI: 10.1016/j.bbrc.2017.03.067
Habitual physical activity protects against lipopolysaccharide-induced inflammation in mouse adipose tissue
Peppler, W.T. and Anderson, Z.G. and MacRae, L.M. and MacPherson, R.E.K. and Wright, D.C.
Beneficial effects of combined resveratrol and metformin therapy in treating diet-induced insulin resistance
Frendo-Cumbo, S. and MacPherson, R.E.K. and Wright, D.C.
Challenging dogma: is hepatic lipid accumulation in type 2 diabetes due to mitochondrial dysfunction?
Perry, C.G.R. and Wright, D.C.
Weighing the effects of exercise and intrinsic aerobic capacity: Are there beneficial effects independent of changes in weight?
Thyfault, J.P. and Wright, D.C.
Sarcolipin knockout mice fed a high-fat diet exhibit altered indices of adipose tissue inflammation and remodeling
MacPherson, R.E.K. and Gamu, D. and Frendo-Cumbo, S. and Castellani, L. and Kwon, F. and Tupling, A.R. and Wright, D.C.
North American ginseng influences adipocyte–macrophage crosstalk regulation of inflammatory gene expression
Journal of Ginseng Research
Garbett, J. and Wilson, S.A.F. and Ralston, J.C. and De Boer, A.A. and Lui, E.M.K. and Wright, D.C. and Mutch, D.M.
DOI: 10.1016/j.jgr.2015.07.001
Reduced ATGL-mediated lipolysis attenuates ß-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue
Macpherson, R.E.K. and Dragos, S.M. and Ramos, S. and Sutton, C. and Frendo-Cumbo, S. and Castellani, L. and Watt, M.J. and Perry, C.G.R. and Mutch, D.M. and Wright, D.C.
Prior exercise training blunts short-term high-fat diet-induced weight gain
Snook, L.A. and Macpherson, R.E.K. and Monaco, C.M.F. and Frendo-Cumbo, S. and Castellani, L. and Peppler, W.T. and Anderson, Z.G. and Buzelle, S.L. and Leblanc, P.J. and Holloway, G.P. and Wright, D.C.
DOI: 10.1152/ajpregu.00072.2016
Voluntary wheel running attenuates lipopolysaccharide-induced liver inflammation in mice
Peppler, W.T. and Anderson, Z.G. and Sutton, C.D. and Rector, R.S. and Wright, D.C.
Hyperactive mTORC1 signaling is unaffected by metformin treatment in aged skeletal muscle
Dungan, C.M. and Li, Z. and Wright, D.C. and Williamson, D.L.
DOI: 10.1002/mus.24698
Combined high-fat-resveratrol diet and RIP140 knockout mice reveal a novel relationship between elevated bone mitochondrial content and compromised bone microarchitecture, bone mineral mass, and bone strength in the tibia
Molecular nutrition & food research
Miotto, P.M. and Frendo-Cumbo, S. and Sacco, S.M. and Wright, D.C. and Ward, W.E. and Holloway, G.P.
DOI: 10.1002/mnfr.201500870
Postprandial control of fatty acid transport proteins' subcellular location is not dependent on insulin
Snook, L.A. and Wright, D.C. and Holloway, G.P.
DOI: 10.1002/1873-3468.12260
Statin therapy alters lipid storage in diabetic skeletal muscle
Frontiers in Endocrinology
Rebalka, I.A. and Raleigh, M.J. and Snook, L.A. and Rebalka, A.N. and MacPherson, R.E.K. and Wright, D.C. and Schertzer, J.D. and Hawke, T.J.
DOI: 10.3389/fendo.2016.00095
Respiratory muscle weakness in the Zucker diabetic fatty rat
Allwood, M.A. and Foster, A.J. and Arkell, A.M. and Beaudoin, M.-S. and Snook, L.A. and Romanova, N. and Murrant, C.L. and Holloway, G.P. and Wright, D.C. and Simpson, J.A.
Exercise-mediated IL-6 signaling occurs independent of inflammation and is amplified by training in mouse adipose tissue
Castellani, L. and Perry, C.G.R. and MacPherson, R.E.K. and Root-McCaig, J. and Huber, J.S. and Arkell, A.M. and Simpson, J.A. and Wright, D.C.
Feeding butter with elevated content of trans-10, cis-12 conjugated linoleic acid to obese-prone rats impairs glucose and insulin tolerance
Lipids in Health and Disease
Hamilton, M. and Hopkins, L.E. and AlZahal, O. and MacDonald, T.L. and Cervone, D.T. and Wright, D.C. and McBride, B.W. and Dyck, D.J.
Adipose tissue mitochondrial respiration: Key insights from RYGB-induced weight loss
MacPherson, R.E.K. and Wright, D.C.
Heat shock proteins: In vivo heat treatments reveal adipose tissue depot-specific effects
Rogers, R.S. and Beaudoin, M.-S. and Wheatley, J.L. and Wright, D.C. and Geiger, P.C.
Dietary mannoheptulose does not significantly alter daily energy expenditure in adult Labrador retrievers
McKnight, L.L. and Root-McCaig, J. and Wright, D. and Davenport, G.M. and France, J. and Shoveller, A.K.
Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice
MacPherson, R.E.K. and Baumeister, P. and Peppler, W.T. and Wright, D.C. and Little, J.P.
Adipose Tissue Insulin Action and IL-6 Signaling after Exercise in Obese Mice
Macpherson, R.E.K. and Huber, J.S. and Frendo-Cumbo, S. and Simpson, J.A. and Wright, D.C.
Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats
Bonen, A. and Jain, S.S. and Snook, L.A. and Han, X.-X. and Yoshida, Y. and Buddo, K.H. and Lally, J.S. and Pask, E.D. and Paglialunga, S. and Beaudoin, M.-S. and Glatz, J.F.C. and Luiken, J.J.F.P. and Harasim, E. and Wright, D.C. and Chabowski, A. and Holloway, G.P.
The contribution of IL-6 to beta 3 adrenergic receptor mediated adipose tissue remodeling
Buzelle, S.L. and MacPherson, R.E.K. and Peppler, W.T. and Castellani, L. and Wright, D.C.
Glucose-dependent insulinotropic polypeptide directly induces glucose transport in rat skeletal muscle
Snook, L.A. and Nelson, E.M. and Dyck, D.J. and Wright, D.C. and Holloway, G.P.
Exercise- and resveratrol-mediated alterations in adipose tissue metabolism
Wright, D.C.
Novel effects of rosiglitazone on SMAD2 and SMAD3 signaling in white adipose tissue of diabetic rats
Beaudoin, M.-S. and Snook, L.A. and Arkell, A.M. and Stefanson, A. and Wan, Z. and Simpson, J.A. and Holloway, G.P. and Wright, D.C.
Aging-associated reductions in lipolytic and mitochondrial proteins in mouse adipose tissue are not rescued by metformin treatment
Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Mennes, E. and Dungan, C.M. and Frendo-Cumbo, S. and Williamson, D.L. and Wright, D.C.
DOI: 10.1093/gerona/glt156
Adiponectin is sufficient, but not required, for exercise-induced increases in the expression of skeletal muscle mitochondrial enzymes
Ritchie, I.R.W. and Macdonald, T.L. and Wright, D.C. and Dyck, D.J.
DOI: 10.1113/jphysiol.2014.273680
Lack of REDD1 reduces whole body glucose and insulin tolerance, and impairs skeletal muscle insulin signaling
Dungan, C.M. and Wright, D.C. and Williamson, D.L.
Feeding butter with elevated content of trans-10, cis-12 conjugated linoleic acid to lean rats does not impair glucose tolerance or muscle insulin response
Stefanson, A. and Hopkins, L.E. and Alzahal, O. and Ritchie, I.R. and Macdonald, T. and Wright, D.C. and McBride, B.W. and Dyck, D.J.
DOI: 10.1186/1476-511X-13-101
The day/night proteome in the murine heart
Podobed, P. and Glen Pyle, W. and Ackloo, S. and Alibhai, F.J. and Tsimakouridze, E.V. and Ratcliffe, W.F. and Mackay, A. and Simpson, J. and Wright, D.C. and Kirby, G.M. and Young, M.E. and Martino, T.A.
Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue
Wan, Z. and Root-Mccaig, J. and Castellani, L. and Kemp, B.E. and Steinberg, G.R. and Wright, D.C.
Exercise training protects against an acute inflammatory insult in mouse epididymal adipose tissue
Castellani, L. and Root-Mccaig, J. and Frendo-Cumbo, S. and Beaudoin, M.-S. and Wright, D.C.
Impairments in mitochondrial palmitoyl-CoA respiratory kinetics that precede development of diabetic cardiomyopathy are prevented by resveratrol in ZDF rats
Beaudoin, M.-S. and Perry, C.G.R. and Arkell, A.M. and Chabowski, A. and Simpson, J.A. and Wright, D.C. and Holloway, G.P.
Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice
MacPherson, R.E.K. and Castellani, L. and Beaudoin, M.-S. and Wright, D.C.
Short-term disruption of diurnal rhythms after murine myocardial infarction adversely affects long-term myocardial structure and function
Circulation Research
Alibhai, F.J. and Tsimakouridze, E.V. and Chinnappareddy, N. and Wright, D.C. and Billia, F. and O{'}Sullivan, M.L. and Pyle, W.G. and Sole, M.J. and Martino, T.A.
DOI: 10.1161/CIRCRESAHA.114.302995
Adiponectin is not required for exercise training-induced improvements in glucose and insulin tolerance in mice
Ritchie, I.R.W. and Wright, D.C. and Dyck, D.J.
IL-6 and epinephrine have divergent fiber type effects on intramuscular lipolysis
MacDonald, T.L. and Wan, Z. and Frendo-Cumbo, S. and Dyck, D.J. and Wright, D.C.
Changes in mechanisms proposed to mediate fat loss following an acute bout of high-intensity interval and endurance exercise
Williams, C.B. and Zelt, J.G.E. and Castellani, L.N. and Little, J.P. and Jung, M.E. and Wright, D.C. and Tschakovsky, M.E. and Gurd, B.J.
FAT/CD36 regulates PEPCK expression in adipose tissue
Wan, Z. and Matravadia, S. and Holloway, G.P. and Wright, D.C.
Correction: IL-6 indirectly modulates the induction of glyceroneogenic enzymes in adipose tissue during exercise (PLoS ONE)
Wan, Z. and Ritchie, I. and Beaudoin, M.-S. and Castellani, L. and Chan, C.B. and Wright, D.C.
DOI: 10.1371/annotation/3029d433-8e4e-41ca-a2da-6561aa0701bd
Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol
Smith, B.K. and Perry, C.G.R. and Herbst, E.A.F. and Ritchie, I.R. and Beaudoin, M.-S. and Smith, J.C. and Neufer, P.D. and Wright, D.C. and Holloway, G.P.
Enhanced glucose homeostasis in BHE/cdb rats with mutated ATP synthase
Harasym, A.C. and Thrush, A.B. and Harper, M.-E. and Wright, D.C. and Chan, C.B.
DOI: 10.1016/j.mito.2013.04.006
IL-6 is not essential for exercise-induced increases in glucose uptake
O{'}Neill, H.M. and Palanivel, R. and Wright, D.C. and Macdonald, T. and Lally, J.S. and Schertzer, J.D. and Steinberg, G.R.
Resveratrol supplementation improves white adipose tissue function in a depot-specific manner in Zucker diabetic fatty rats
Beaudoin, M.-S. and Snook, L.A. and Arkell, A.M. and Simpson, J.A. and Holloway, G.P. and Wright, D.C.
Dietary supplementation with vitamin E and C attenuates dexamethasone-induced glucose intolerance in rats
Williams, D.B. and Wan, Z. and Frier, B.C. and Bell, R.C. and Field, C.J. and Wright, D.C.
Epinephrine induces PDK4 mRNA expression in adipose tissue from obese, insulin resistant rats
Wan, Z. and Frier, B.C. and Williams, D.B. and Wright, D.C.
DOI: 10.1038/oby.2011.252
Epinephrine and AICAR-induced PGC-1a mRNA expression is intact in skeletal muscle from rats fed a high-fat diet
Frier, B.C. and Wan, Z. and Williams, D.B. and Stefanson, A.L. and Wright, D.C.
IL-6 Is Not Necessary for the Regulation of Adipose Tissue Mitochondrial Content
Wan, Z. and Perry, C.G.R. and Macdonald, T. and Chan, C.B. and Holloway, G.P. and Wright, D.C.
Identification of a novel malonyl-CoA IC50for CPT-I: Implications for predicting in vivo fatty acid oxidation rates
Smith, B.K. and Perry, C.G.R. and Koves, T.R. and Wright, D.C. and Smith, J.C. and Neufer, P.D. and Muoio, D.M. and Holloway, G.P.
DOI: 10.1042/BJ20121110
Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle
Perry, C.G.R. and Kane, D.A. and Herbst, E.A.F. and Mukai, K. and Lark, D.S. and Wright, D.C. and Heigenhauser, G.J.F. and Neufer, P.D. and Spriet, L.L. and Holloway, G.P.
Exercise restores insulin, but not adiponectin, response in skeletal muscle of high-fat fed rodents
Gulli, R.A. and Tishinsky, J.M. and MacDonald, T. and Robinson, L.E. and Wright, D.C. and Dyck, D.J.
IL-6 indirectly modulates the induction of glyceroneogenic enzymes in adipose tissue during exercise
Skeletal muscle and beyond: The role of exercise as a mediator of systemic mitochondrial biogenesis
Little, J.P. and Safdar, A. and Benton, C.R. and Wright, D.C.
DOI: 10.1139/h11-076
The effects of glucocorticoids on adipose tissue lipid metabolism
Metabolism: Clinical and Experimental
Peckett, A.J. and Wright, D.C. and Riddell, M.C.
DOI: 10.1016/j.metabol.2011.06.012
Reductions in RIP140 are not required for exercise- and AICAR-mediated increases in skeletal muscle mitochondrial content
Frier, B.C. and Hancock, C.R. and Little, J.P. and Fillmore, N. and Bliss, T.A. and Thomson, D.M. and Wan, Z. and Wright, D.C.
Interactions between the consumption of a high-fat diet and fasting in the regulation of fatty acid oxidation enzyme gene expression: An evaluation of potential mechanisms
Frier, B.C. and Jacobs, R.L. and Wright, D.C.
Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp rat
Jacome-Sosa, M.M. and Lu, J. and Wang, Y. and Ruth, M.R. and Wright, D.C. and Reaney, M.J. and Shen, J. and Field, C.J. and Vine, D.F. and Proctor, S.D.
DOI: 10.1186/1743-7075-7-60
Epinephrine-mediated regulation of PDK4 mRNA in rat adipose tissue
Wan, Z. and Thrush, A.B. and Legare, M. and Frier, B.C. and Sutherland, L.N. and Williams, D.B. and Wright, D.C.
The effects of apelin treatment on skeletal muscle mitochondrial content
Frier, B.C. and Williams, D.B. and Wright, D.C.
Adiponectin resistance precedes the accumulation of skeletal muscle lipids and insulin resistance in high-fat-fed rats
Mullen, K.L. and Pritchard, J. and Ritchie, I. and Snook, L.A. and Chabowski, A. and Bonen, A. and Wright, D. and Dyck, D.J.
Exercise and adrenaline increase PGC-1a mRNA expression in rat adipose tissue
Sutherland, L.N. and Bomhof, M.R. and Capozzi, L.C. and Basaraba, S.A.U. and Wright, D.C.
Muscle-specific differences in the response of mitochondrial proteins to ß-GPA feeding: An evaluation of potential mechanisms
Williams, D.B. and Sutherland, L.N. and Bomhof, M.R. and Basaraba, S.A.U. and Thrush, A.B. and Dyck, D.J. and Field, C.J. and Wright, D.C.
Trans-11 vaccenic acid reduces hepatic lipogenesis and chylomicron secretion in JCR: LA-cp rats
Journal of Nutrition
Wang, Y. and Jacome-Sosa, M.M. and Ruth, M.R. and Goruk, S.D. and Reaney, M.J. and Glimm, D.R. and Wright, D.C. and Vine, D.F. and Field, C.J. and Proctor, S.D.
DOI: 10.3945/jn.109.109488
PGC-1a-mediated regulation of gene expression and metabolism: Implications for nutrition and exercise prescriptions
Benton, C.R. and Wright, D.C. and Bonen, A.
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
Hancock, C.R. and Han, D.-H. and Chen, M. and Terada, S. and Yasuda, T. and Wright, D.C. and Holloszy, J.O.
Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: Potential mechanisms and the relationship to glucose intolerance
Sutherland, L.N. and Capozzi, L.C. and Turchinsky, N.J. and Bell, R.C. and Wright, D.C.
Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans
Thrush, A.B. and Heigenhauser, G.J. and Mullen, K.L. and Wright, D.C. and Dyck, D.J.
Antioxidant supplemention in the treatment of skeletal muscle insulin resistance: Potential mechanisms and clinical relevance
Wright, D. and Sutherland, L.
Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1a expression
Wright, D.C. and Han, D.-H. and Garcia-Roves, P.M. and Geiger, P.C. and Jones, T.E. and Holloszy, J.O.
DOI: 10.1074/jbc.M606116200
Calcium induces increases in peroxisome proliferator-activated receptor ¿ coactivator-1a and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activation
Wright, D.C. and Geiger, P.C. and Han, D.-H. and Jones, T.E. and Holloszy, J.O.
Mechanisms of calcium-induced mitochondrial biogenesis and GLUT4 synthesis
IL-6 increases muscle insulin sensitivity only at superphysiological levels
Geiger, P.C. and Hancock, C. and Wright, D.C. and Han, D.-H. and Holloszy, J.O.
How muscle insulin sensitivity is regulated: Testing of a hypothesis
Geiger, P.C. and Dong, H.H. and Wright, D.C. and Holloszy, J.O.
Are tyrosine kinases involved in mediating contraction-stimulated muscle glucose transport?
Wright, D.C. and Geiger, P.C. and Han, D.-H. and Holloszy, J.O.
Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men
Magkos, F. and Wright, D.C. and Patterson, B.W. and Mohammed, B.S. and Mittendorfer, B.
Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin
Geiger, P.C. and Wright, D.C. and Han, D.-H. and Holloszy, J.O.
Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle
Wright, D.C. and Geiger, P.C. and Holloszy, J.O. and Han, D.-H.
A role for calcium/calmodulin kinase in insulin stimulated glucose transport
Wright, D.C. and Fick, C.A. and Olesen, J.B. and Lim, K. and Barnes, B.R. and Craig, B.W.
DOI: 10.1016/j.lfs.2003.06.041
Phorbol esters affect skeletal muscle glucose transport in a fiber type-specific manner
Wright, D.C. and Geiger, P.C. and Rheinheimer, M.J. and Han, D.H. and Holloszy, J.O.
Ca2+ and AMPK Both Mediate Stimulation of Glucose Transport by Muscle Contractions
Wright, D.C. and Hucker, K.A. and Holloszy, J.O. and Han, D.H.
DOI: 10.2337/diabetes.53.2.330
Evidence for the involvement of a phospholipase C - protein kinase C signaling pathway in insulin stimulated glucose transport in skeletal muscle
Wright, D.C. and Fick, C.A. and Olesen, J.B. and Craig, B.W.
DOI: 10.1016/S0024-3205(03)00256-X
Preliminary report: The effects of phospholipase C inhibition on insulin-stimulated glucose transport in skeletal muscle
Wright, D.C. and Craig, B.W. and Fick, C.A. and Lim, K.I.
DOI: 10.1053/meta.2002.30500
CIHR Project Grant: Identifying a Novel Role for GDF15 during Exercise
Exercise has profound effects on virtually every organ and tissue and profoundly influences how the body utilizes carbohydrate and fats. The wide-ranging effects of exercise are mediated, at least in part, by signaling factors secreted from different tissues, such as muscle, liver and fat tissue. A recently identified signaling factor that increases with exercise is GDF15. This molecule signals to the brain and regulates food intake. In addition, we have found that GDF15 also increases the utilization of fat in the liver and the production of molecules called ketone bodies that can be taken up and used as a fuel source by other tissues like the heart and muscle. The purpose of the current project is to determine how GDF15 increases the production of ketone bodies, and then investigate if GDF15 regulates the effects of exercise on these processes. It is our hope that identifying how GDF15 controls sugar and fat metabolism and the role that it plays in exercise, will lend insight into potential new avenues to treat conditions of altered sugar metabolism such as those seen in type 2 diabetes.
CIHR Project Grant: Targeting Exercise Activated Pathways to Offset the Metabolic Side Effects of Anti-Psychotic Drugs
Antipsychotic drugs are used to treat a number of conditions including schizophrenia, anxiety and bipolar disorders and their use has increased dramatically over the past decade. Unfortunately, these drugs have harmful metabolic side effects such as weight gain and rapid increases in blood sugar with each dose of drug. Together these effects increase the risk for developing type 2 diabetes and cardiovascular disease. In recent work, we have shown that a single session of exercise prior to treatment with antipsychotics completely protected against the acute increase in blood sugar. Although exercise adherence is poor in individuals taking anti-psychotic drugs we have been using exercise as a model to identify pathways which could be targeted to reduce the metabolic side effects of these drugs. Based on preliminary data from our laboratory we have shown that the activation of an energy-sensing enzyme called AMPK confers the same protection against anti-psychotic metabolic side effects as exercise. The purpose of this project is to examine the effects of AMPK in protecting against the acute and long-term metabolic side effects of anti-psychotic drugs and to determine if AMPK mediates the beneficial effects of exercise. The data generated from these studies will provide insight into new approaches that could be used to lessen the metabolic consequences of anti-psychotic drugs and could shed insight into the mechanisms mediating the protective effects of exercise.
NSERC Discovery Grant: Temperature Sensing and the Regulation of Fuel Metabolism
The long-term objective of my NSERC program is to examine how environmental, nutritional and exercise stressors modulate adipose tissue and liver metabolism, the underlying mechanisms therein, and how this influences systemic carbohydrate and fat homeostasis. To address these basic, fundamental questions, we use rodent models coupled with cell/tissue culture approaches and examine endpoints ranging from whole body energy expenditure to the regulation of gene expression. A new direction we have started to explore is the impact of cold stress on adipose tissue and systemic metabolism. Building upon recent discoveries, and further guided by exciting
preliminary data, over the next 5 years we will examine how the sensation of cold triggers metabolic adaptations, specifically examining the role of the cold sensing cation channel TRPM8 (Transient Receptor Potential cation channel subfamily Melastatin member 8) in these processes. In the first two aims we will decipher the mechanisms through which activation of TRPM8 acutely increases thermogenesis (Aim 1) and how the repeated activation of TRPM8 induces the expression of mitochondrial/thermogenic genes and proteins (Aim 2). In Aim 3 we will investigate the necessity of TRPM8 in mediating the metabolic response to cold and in Aim 4 will explore interactions between TRPM8 activation and exercise in the regulation of adipose tissue and systemic metabolism. The experiments outlined in this proposal will increase our basic, fundamental understanding of adipose tissue biology and how these changes impact systemic fuel metabolism. A diverse group of HQP will receive a rich training experience which will prepare them for careers, or further training, in the natural sciences.
CIHR Project Grant (2021-26): Identifying a Novel Role for GDF15 during Exercise
CIHR Project Grant (2018-24): Targeting Exercise Activated Pathways to Offset the Metabolic Side Effects of Anti-Psychotic Drugs
NSERC Discovery Grant (2017-22): Role of Adipose Tissue and IL-6 in Liver Metabolism
Tier II Canada Research Chair in Lipids, Metabolism and Health (2010-2020)
Young Investigator Award Canadian Society of Exercise Physiology (2012)
CIHR New Investigator Award (2008-10)
Meagan Arbeau
AnnaLaura Bellucci, doctoral student
Stewart Jeromson, Postdoctoral Fellow
Kyle Medak
The importance of diet with antipsychotic medication: Q&A with new investigator Dr. David Wright
Dr. David Wright is a new investigator with BC Children's Hospital Research Institute aiming to develop treatment that can reduce the side effects of antipsychotic drugs in children and adults.
Continue reading The importance of diet with antipsychotic medication: Q&A with new investigator Dr. David Wright
Do common food additives increase kids' risk of inflammatory bowel disease?
We asked Dr. Genelle Healey about emerging research that shows associations between consuming food additives and development or worsening of inflammatory bowel disease, such as Crohn's disease and ulcerative colitis.
Continue reading Do common food additives increase kids' risk of inflammatory bowel disease?
New project hopes to uncover the origins of type 1 diabetes
A team of researchers at BC Children's is doing a deep dive into why the immune system attacks islet cells — the cells in the pancreas that produce insulin — and how metabolic pathways are involved. This could lead to new treatments for type 1 diabetes.
Continue reading New project hopes to uncover the origins of type 1 diabetes
When research is personal
Lindsay Pallo and Raelyn Gallant were both diagnosed with type 1 diabetes as children. Now they're conducting diabetes research in Dr. Bruce Verchere's lab. Read about their lived experience and how that enriches their work.
Continue reading When research is personal
Outstanding Achievement Award by a Master's Student: Dr. Kristen Favel
Dr. Kristen Favel is the 2022 recipient of BCCHR's Outstanding Achievement Award by a Master's Student. Her passion for pediatric type 1 diabetes (T1D) research and clinical care drove her to make significant discoveries that could transform the national standard of care for children with T1D.
Continue reading Outstanding Achievement Award by a Master's Student: Dr. Kristen Favel
Video games can trigger deadly heart rhythms in at-risk kids
Video games can cause life-threatening irregular heart rhythms in susceptible children, according to a new study co-authored by BC Children's Dr. Shubhayan Sanatani and published last week in the journal Heart Rhythm, believed to be the first research into this subject.
Continue reading Video games can trigger deadly heart rhythms in at-risk kids

redpajama_set_name: RedPajamaCommonCrawl


criteria for user agents in an effort to improve interoperability.
our public bug database. All feedback is welcome.
that have not yet been resolved.
aforementioned mailing lists and take part in the discussions.
of the participants in the W3C HTML working group endorse the contents of the specification.
copy (which may contain unfinished text in the process of being prepared) is also available.
identical from the table of contents onwards.
HTML4, XHTML 1.0, and DOM2 HTML specifications.
Different parts of this specification are at different levels of maturity.
all use different text to fire events, etc).
updating the HTML specifications to address issues raised in the past few years.
implementations with respect to the requirements of this specification.
clearly presentational and authors wishing to cause text to blink should instead use CSS.
to allow reuse of the specifications.
license on the WHATWG site.
serialization of the HTML vocabulary.
specifications, and therefore cannot be considered a complete replacement for them.
mechanism are encouraged to continue using the XHTML 1.1 line of specifications.
semantics of human literary works such as poems and scientific papers.
e-mail applications, word processors, real-time strategy games, and the like.
This specification aims to extend HTML so that it is also suitable in these contexts.
be implemented in the same XML processor.
The in-memory representation is known as "DOM5 HTML", or "the DOM" for short.
abstract language, two of which are defined in this specification.
The first such concrete syntax is "HTML5". This is the format recommended for most authors.
, then it will be processed as an "HTML5" document by Web browsers.
ignored in the "HTML5" syntax.
"DOM5 HTML". Comments that contain the string "
" can be represented in "DOM5 HTML"
but not in "HTML5" and "XHTML5". And so forth.
all elements, and the concepts used in defining elements.
handle each element, are also given.
modify content, which are described in this section.
running on the same client.
with rules for how to parse HTML.
areas that are out of scope for this specification.
?Warning! This is a warning.
attributes for HTML and XML attributes, and DOM attributes for those from the DOM.
parser or created purely through the DOM).
(this does not apply to XHTML)".
visual medium; they must be considered to apply to other media in equivalent ways.
specification have no namespace (they are in the per-element partition).
ASCII case-insensitive match for the string "
document tree, the root element will be an orphaned node.
in the DOM. A user agent must not mutate the DOM in such situations.
and is said to be setting when a new value is assigned to it.
a plugin by this definition.
those in the user agent.
0x26, 0x27, 0x2C - 0x3F, 0x41 - 0x5A, and 0x61 - 0x7A.
explicitly marked non-normative. Everything else in this specification is normative.
uppercase letters in this specification.
meaning of the key word ("must", "should", "may", etc) used in introducing the algorithm.
implementors) and documents (relevant to authors and authoring tool implementors).
the conformity of the input documents.
element as an opaque element that forms part of the transform.
described in this specification, so that users can interact with them.
fragments in this specification, as described in the WebIDL specification.
except that they are exempt from requirements regarding user interaction.
the UA would not need to support any of the focus-related DOM APIs.
events and the DOM were supported.
unable to fully convey the author's intent.
elements only contain quoted material).
conforms to the applicable requirements of this specification.
Criteria that can be expressed in a DTD.1.
Criteria that can only be checked by a human.3.
conforming conformance checker according to this specification.
accordance to the semantics of the documents that they process.
Authoring tools and markup generators must generate conforming documents.
elements and attributes are most appropriate.
enabling users to create well-structured, semantically rich, media-independent content.
these two formats, although supporting both is encouraged.
implementations are defined, in this specification, in terms of operations on the DOM.
as extensions to the DOM Core interfaces.
IDL fragments, as described in the Web IDL specification.
Implementations must support some version of the Media Queries language.
This section will eventually be removed in favour of WebIDL.
"indexth" liberally. We should define those to be zero-based and be clearer about this.
method in its IDL definition, the excess arguments must be ignored.
This specification defines several comparison operators for strings.
codepoint for codepoint, except that the characters in the range U+0041 .. U+005A (i.e.
are considered to also match.
compatibility caseless match operation to compare the two strings.
Converting a string to uppercase means replacing all characters in the range U+0061 ..
Converting a string to lowercase means replacing all characters in the range U+0041 ..
truncating s to pattern's length leaves the two strings as matches of each other.
and how to parse them.
and U+000D CARRIAGE RETURN (CR).
are those that have the Unicode property "White_Space".
algorithm that invoked these steps.
Let result be the empty string.2.
the collected characters are not used.
of a string is the number of Unicode codepoints in that string.
represent a false value, the attribute has to be omitted altogether.
U+0030 DIGIT ZERO (0) to U+0039 DIGIT NINE (9).
ignored. Trailing spaces and indeed any trailing garbage characters are ignored.
Let input be the string being parsed.1.
Let position be a pointer into input, initially pointing at the start of the string.2.
Let value have the value 0.3.
If position is past the end of input, return an error.5.
If position is past the end of input, return an error.7.
Add the value of the current character (0..9) to value.2.
Advance position to the next character.3.
algorithm (that's the step within which these substeps find themselves).
digits that follows the U+002D HYPHEN-MINUS, subtracted from zero.
Let sign have the value "positive".4.
If position is past the end of input, return an error.6.
Advance position to the next character.2.
If position is past the end of input, return an error.3.
If sign is "positive", return value, otherwise return 0-value.10.
Optionally, a U+002D HYPHEN-MINUS ("-") character.1.
A single U+002E FULL STOP (".") character.1.
Either a U+0065 LATIN SMALL LETTER E character or a U+0045 LATIN1.
is one). If there is no E, then the exponent is treated as zero.
the ECMAScript operator ToString to n.
The rules for parsing floating point number values are as given in the following algorithm.
Let value have the value 1.3.
Let divisor have the value 1.4.
Let exponent have the value 1.5.
Change value and divisor to −1.1.
DIGIT NINE (9), then return an error.
Collect a sequence of characters in the range U+0030 DIGIT ZERO (0) to U+003910.
If position is past the end of input, return value.11.
Advance position to the next character.1.
one of U+0030 DIGIT ZERO (0) .. U+0039 DIGIT NINE (9), then return value.
Fraction loop: Multiply divisor by ten.3.
Advance position to the next character.5.
If position is past the end of input, then return value.6.
DIGIT NINE (9), return to the step labeled fraction loop in these substeps.
If position is past the end of input, then return value.2.
If position is past the end of input, then return value.3.
If the character indicated by position is not one of U+0030 DIGIT ZERO (0) ..
U+0039 DIGIT NINE (9), then return value.
DIGIT NINE (9), and interpret the resulting sequence as a base-ten integer.
Multiply exponent by that integer.
Multiply value by ten raised to the exponentth power.6.
A valid denominator punctuation character is one of the characters from the table below.
If the string is empty, then return nothing and abort these steps.1.
nothing and abort these steps.
Set number1 to the number returned by the sub-algorithm in step 2.4.
valid denominator punctuation character, set denominator to that character.
examined by the sub-algorithm in step 2.
If the sub-algorithm in step 9 returned nothing or an error condition, return number1 and10.
Set number2 to the number returned by the sub-algorithm in step 9.11.
valid denominator punctuation character, return nothing and abort these steps.
DIGIT NINE, return nothing and abort these steps.
Otherwise, return number1 and number2.15.
returns either nothing, a number, or an error condition.
range U+0030 DIGIT ZERO to U+0039 DIGIT NINE.
If there are no such characters, return nothing and abort these steps.2.
number is returned, then it is further categorised as either a percentage or a length.
If position is past the end of input, return an error.4.
If position is past the end of input, return value as an integer.10.


Beautifully updated Pinecrest 3br/2ba on great street!
This house has so much to offer. Nice covered and screened patio and pool, updated kitchen and baths, huge family room with vaulted ceilings, separate formal living and dining rooms, wood floors, laundry room and excellent schools.
Pool and lawn included. Nice big lot giving you space and privacy from your neighbors!


Bloomberg PolarLake is seeking an experienced Quality Assurance Engineer to work as part of the expanding QA & Test function for its Managed Service which includes the testing framework for a large web-based application. You will be a self-motivated problem solver with hands-on experience in QA & Test function with a desire to work in a fast-paced environment.
The purpose of this role is develop and maintain QA Test Cases (both manual and automated), ensure that quality assurance and testing is carried out in accordance with industry best practise and follows strict audit standards. This role will involve working with offshore and onshore teams.
To create and execute test plans and report on test execution.
Represent QA function at team meetings when required.
Ability to triage complex issues to ensure they are directed to the correct team.


Appleton, Wisconsin. The Appleton Home Staging Cost Report is a concise report on everything you need to know about the cost of home staging in the Appleton area.
The cost of home staging services is included in the estimate. Price takes into account removing clutter and rearranging furniture. Items excluded: furniture rental and home repairs.


All applicants should send their CV's into enquries@nricivils.co.uk quoting the job description as reference.
NRI Civils was formed in 2012, and is involved in the constructing of major Civil Engineering works (Roads and Sewers) and private Groundworks (Foundations, Concrete Floors etc.) for national house builders such as Persimmon Homes, TaylorWimpey, Morris Homes and Orbit Homes and has an annual turnover of circa £13million.
Our management team is based in our Head Office (Great Oakley, Northants) and we are split into four departments…..Construction / Commercial / Buying / Accounts. The whole team benefits from a friendly but cohesive working environment, and our main strengths are being forward thinking by taking a proactive stance on day to day activities which can improve our efficiency and working environment.
Our main objective is to form a 'Partnership' with our clients and suppliers, to continue to provide a personal and professional service.


text:
Q: Inequalty with complex numbers i'm being fighting with this for a long, it shouldn't be that hard, can you provide some ideas?
Let a,b on $\mathbb{C}$ if |a|<1 and |b|<1 prove:
$$\left|\frac{a-b}{1-\bar{a}b}\right| < 1$$
Thanks!

A: The inequality is equivalent to
$$|a-b|<|1-\bar{a}b|$$
thus to
$$(a-b)(\bar{a}-\bar{b})<(1-\bar{a}b)(1-a\bar{b})$$
which you can expand to
$$a\bar{a}-a\bar{b}-\bar{a}b+b\bar{b}<1-\bar{a}b-a\bar{b}+a\bar{a}b\bar{b}$$
so it reduces to
$$|a|^2 + |b|^2 < 1 + |a|^2\,|b|^2$$
that is
$$(1-|a|^2)(1-|b|^2)>0$$
which is true by hypothesis.
Notice that $\bar{a}b\ne1$, because that would imply
$$|a||b|=1$$
which can't happen under your hypotheses.


I love thee for thou savest me allll the money.
I love thee for thou savest the environment.
I love thee as I now have beautiful *almost* plastic-free cupboards that look like they are straight outta Pinterest.
Bulk buying has changed my life. When I first heard about it, it seemed much too intimidating and if I'm being real, TOO MUCH WORK. Plus, I was certain it would be more expensive. After careful consideration* I made my way to the least intimidating option, my local Bulk Barn. After some fumbling, and awkward conversations** I got it done. I purchased lentil pasta (bad choice, $$$ and just plain gross), some spices and hemp hearts. Despite the expensive pasta, I STILL spent less on those items than I would have at my chain grocer! I was shocked how much money I saved, and my next couple forays into bulk buying led me to have amazing conversations with people at the checkout as well as the customers standing in line. Who knew reusable produce bags were such a conversation starter?
So how do you get started?!
1. Get some reusable bags and some jars. You can use empty, clean jars from products you've used up or purchase them at a thrift store. I bought my produce bags on Amazon when I hadn't yet fallen down the eco rabbit hole. I suggest sewing them (you can find a simple tutorial here) or supporting someone local through Etsy... like me.
2. Purchase a funnel. Trust me. It will save you from awkwardly yelling CLEANUP IN AISLE THREE and then shamefully running away.
3. Make sure it's all clean and, most importantly, dry.
4. Ask the cashier to weigh (or tare) your jars and bags.
5. Fill em' up! Take a picture of the bin number, or type it in your phone.
6. Finally, pay for your purchases and bask in the glory of a job well done.
I honestly spend less money and have more time since bulk buying. Not having to recycle packaging or sent said packaging to landfill is so freeing, and I'm in and out of the store in less than 10 minutes.
I live in Kamloops, British Columbia, so I have created a list of stores where you can purchase bulk and package-free items, as well as their relative costs. If you live anywhere else click here for Litterless blog's amazing directory. If you have something to add to my list, hit me up here.
· Psyllium husks (don't know what these are? Check out this post and recipe https://www.mynewroots.org/site/2013/02/the-life-changing-loaf-of-bread/ by My New Roots. It is truly life-changing.).
Oil… and vinegar. You can bring back the bottles and they will reuse them.
And don't forget… if you forget your produce bags and are afraid of your veggies getting too intimate, use a couple brown paper mushroom bags!
*Just kidding, I grabbed a couple jars and hoofed it to the store. Impulsive is my middle name, uncomfortable scenarios are my game.
**The staff weren't used to people bringing in jars. It's literally what the company is about, but apparently jars haven't caught on here yet. There is a giant poster of a jar on the front window. But, you know, convenience still abounds.


text:
module REPL
  class GetTasks

    def initialize(todo_list: )
      request = GetTasksRequest.new todo_list: todo_list
      response = ::GetTasks.new request

      case response.outcome
      when :found
          response.result.each do |task|
            puts "#{task.id}: #{task.instruction}"
          end
      when :bad_request
        puts "Request had invalid details"
      when :not_found
        puts "TodoList with name '#{request.todo_list_name}' not_found"
      end
    end

  end
end

redpajama_set_name: RedPajamaGithub


We can tell you the price of a degree - but that's not the same as its value. You really can't put a price on turning your dream into reality.
If you are an eligible full-time undergraduate student from the UK or EU you can apply for a tuition fee loan to cover the full cost of your fees each year. The tuition fee loan is repayable - but not until you've left university and your income is over £25,000 a year.
Pay back your student loan (tuition and maintenance) when you are earning over £25,000 a year. Repayments will be 9% of your income above £25,000, so the amount repaid each month depends on how much you earn.
If you are a social work student you can apply for all of the funding listed above in the same way as other students, however you may also be entitled to a social work bursary from the NHS in Year 2 and Year 3 of the BA (Hons) Social Work. We are waiting for government confirmation about the bursary for 2019-20.
Teesside University provides a care leavers' bursary of £1,000 a year for those students who come to us from a care background. Find out more from Student Finance (contact details below).
This course does not attract any funding from the Student Loans Company as it doesn't meet their eligibility criteria. This means that you won't be able to obtain a tuition fee loan to cover the fees and should be prepared to self-fund this course.
Eligible part-time students can apply for a tuition fee loan to cover the cost of their course. You may also be entitled to receive a maintenance loan to help towards your living costs. All eligible students receive the tuition fee loan but your entitlement to the maintenance loan depends on a number of factors including the level of course and household income. Both the loans are repayable but repayments only start if you are earning over £25,000 in the April four years after the start of your course or the April after you leave your course, whichever comes first.
Employers may be able to pay part or all of your fees up front if you ask them. You get to study for a qualification that will improve your ability to do your job and advance your career, and your employer benefits from a better-qualified, more productive and motivated employee.
If you hold at least an honours degree or higher level higher education qualification and start a part-time honours degree course in science, technology, engineering or maths you may qualify for a part-time fee loan for a new course. Please contact a student adviser in Student and Library Services for advice about which courses qualify for part-time funding in these circumstances.
If you have attended a higher education course before, this can have an impact on the funding you get for any course you want to do in the future. Please contact a student adviser in Student and Library Services for advice about your edibility before starting a course.
You may also be eligible for other forms of support that don't have to be paid back.


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The complete abandonment of the Christian religion and not merely a denial of some article of the creed. Since apostolic times, it was classified among the major crimes, along with murder and adultery, whose remission in the sacrament of penance carried severe censures and, among certain rigorists, even remission of the sin was denied. St. Cyprian (d. 258), Bishop of Carthage, defended the Church's right to remit apostasy before the hour of death, and the practice was supported by Pope Cornelius (d. 253). Under the Christian Roman Empire, apostates were punished by deprivation of civil rights, including the power to bequeath or inherit property. During the late Middle Ages, Christian who apostatized were subject to trial and punishment by the Inquisition.
The Code of Canon Law of 1918 declared that apostates from the faith (as also heretics and schismatics) incur ipso facto excommunication, are deprived, after warning, of any benefice, dignity, pension, office, or any position they may have in the Church, and are declared under infamy. After a second warning, clerics are to be deposed, and members of a religious community automatically dismissed.


text:
ZIP code 99630 Education Attainment Charts
This section of charts contains education data for ZIP code 99630 Alaska based mainly on the latest year 2022 Census data using the American Community Survey but also the survey from Common Core Data available for Public Elementary through Secondary Schools. In Figure 1, the percent of all people aged 25 years or older, who have either graduated from high school or completed the Graduate Equivalency Degree (GED) or some equivalent certification/credential. 99630 depicts it has a High School Grad or higher of 80% which is in the mid range of other zip codes in the greater region. The zip code with the highest percent high school graduates or better in the area is 99681 which depicts a high school graduates of 90% (12.6% larger).
In Figure 2, the percentage of people aged 25 years or older who have graduated from college/university with at least a bachelor's degree is provided. Note that the bachelor's degree is also called a four-year degree because it normally takes four years of full-time study to finish the course curriculum required to obtain the degree. This chart portrays the proportion of the population in this region who are college graduates with at least a bachelor degree or higher. In many ways, this analysis alongside the prior chart are very quick measures of the level of education in any particular area. ZIP code 99630 shows it has a Bachelors Degree or higher of 5% which is the second most percent with a bachelors degree or higher of all the zip codes in the greater ZIP code 99630 region. The zip code with the highest percent with a bachelors degree or higher in the area is 99637 which depicts a percent with a bachelors degree of 15% (approximately 2.9 times bigger).
Figure 4 shows the percentage of people 25 years of age or older who either have no schooling at all or dropped out of school before being able to complete high school. Additionally, these are people who also do not have a Graduate Equivalency Degree (GED) or some other high school level type credential/student achievement. This analysis, along with the last two charts, provides another high level review and comparative data on the ZIP code 99630 Alaska educational level. 99630 shows it has a School Dropout Rate of 20% which is in the center range of other zip codes in the metro area. The zip code with the highest percent who dropped out of school in the area is 99561 which depicts a percent who dropped out of school of 26% (29.8% larger).
Figure 5 provides a more detailed look at the educational attainment for ZIP code 99630 Alaska. This chart provides the proportion of people aged 25 years of age or older and what was their level of educational attainment. The chart provides 5 broad categories including: No Education/No School, Some High School, High School or equivalent, Some college or Associates Degree, and Bachelors Degree or higher. ZIP code 99630 has one of the largest proportions of percent of people with no schooling at 20% of the total and is ranked #3. Only #2 99614 (22%), and #1 99561 (24%) are larger. Second, it has less than most other zip codes in the surrounding region in terms of percent of people with less than a high school education at 50% of the total.
The next chart shows a break down of people who have received a bachelor's degree or higher advanced degree generally in a campus learning environment. In particular, Figure 6, provides the proportional breakdown of all the people who have received a postsecondary education along with what the level of advanced degree that was obtained. Note that these categories do not include any type professional development type activities such as those related to maintaining professional credentials in workshop lessons. Note Professional Degree includes medical, dental, lawyers, etc. ZIP code 99630 has one of the largest proportions of percent of people with an associate degree at 35% of the total and is ranked #3. Only #2 99561 (42%), and #1 99681 (62%) are larger. Second, it has one of the largest proportions of percent of people with a bachelors degree at 29% of the total and is ranked #2. The only larger zip code being 99637 with 62%.
The chart in Figure 7 shows the broad area of academic concentration or the discipline for people who have received a bachelors degree. This high level classification is essentially the field of study for which a degree was obtained. ZIP code 99630 has the largest proportion of percent of people with a science or engineering degree at 45.5% of the total and is ranked #1. Second, it has the largest proportion of percent of people with an arts, humanities, or other degree at 27.3% of the total and is ranked #1.
The next chart (Figure 8) provides a more detailed deep dive on the category of major degree obtained for people aged 25 years or older who earned a bachelor's degree or higher. Specifically, this frequency distribution details out what the major field of study was the degree obtained. ZIP code 99630 has the largest proportion of percent of people with a degree in social sciences at 27.3% of the total and is ranked #1. Second, it has the largest proportion of percent of people with a degree in multidisciplinary studies at 45.5% of the total and is ranked #1. Third, it has the largest proportion of percent of people with a degree in science and engineering related fields at 27.3% of the total and is ranked #1.
Figure 9 provides comparative data between the places in the greater ZIP code 99630 Alaska region for broad educational attainment. This analysis uses provides five broad education attainment categories including: No Education/No School, Some High School, High School or equivalent, Some college or Associates Degree, and Bachelors Degree or higher. ZIP code 99630 has the percentage of percent of people with less than a high school degree less than most other zip codes in the metro area at 49.8% of the total. Second, it has in the middle range of other zip codes in the local area when sorted by percent of people with high school (or ged) at 25.1% of the total.
A more detailed frequency distribution of educational attainment is provided in Figure 10. In particular this illustration breaks out the highest levels of university educational opportunities beyond the four year college degree. Included in the breakout are the relative proportion of masters degrees, PhD/Doctorate/Doctorial holders, and professional degrees such as medicine, dentistry, lawyers, etc. ZIP code 99630 has one of the largest proportions of percent of people with no schooling at 19.9% of the total and is ranked #3. Only #2 99614 (21.8%), and #1 99561 (24.2%) are larger. Second, it has less than most other zip codes in the greater region when sorted by percent of people with less than high school at 49.8% of the total. The next exhibit (Figure 11) provides detailed cross tabulation analysis that provides education success data broken out or cross tabulated by age group. Please note that the columns add to 100% and you must use the pagination buttons at the bottom of the table to see all the rows.
ZIP code 99630 School Enrollment Charts
The next section of chart resources look at school enrollment by a variety of educational institutions and are categorized into a number of other groupings. Figure 14 provides the overall school enrollment by broad range of school age/level groupings. ZIP code 99630 has the percentage of percent of children in kindergarten in the center range of other zip codes in the greater region at 28.4% of the total. Second, it has one of the largest proportions of percent of children in grade 1 to 4 at 30.7% of the total and is ranked #3. Only #2 99690 (34.2%), and #1 99614 (39.2%) are larger. Third, it has one of the largest proportions of percent of children in grades 5 to 8 at 34.1% of the total and is ranked #3. Only #2 99690 (34.2%), and #1 99637 (45.9%) are larger.
The next chart in this series of resources shown in Figure 20 looks at the total number of students enrolled in any educational institution for each place in the greater ZIP code 99630 region. (Total enrollment in this case includes all students from preschool all the way through students enrolled in graduate school.) ZIP code 99630 shows it has a Total Enrolled of 97 which is the second smallest in order of total population enrolled in school of all the other zip codes in the local area. The zip code with the highest total population enrolled in school in the area is 99637 which depicts a total population enrolled in school of 323 (approximately 3.3 times bigger). Comparing total population enrolled in school to the United States average of 81,076,829, ZIP code 99630 is only about 0.0% the size. Also, measured against the state of Alaska, total population enrolled in school of 180,211, ZIP code 99630 is only about 0.1% the size.
ZIP code 99630 Area Schools Charts
Figure 23 lists all the schools in the area along with the school district, county location and other program information/credential such as if they are a public charter school or private charter school or magnet school. Some of the Area Schools are: Nuniwarmiut School, Paul T. Albert Memorial School, Nelson Island Area School, Negtemiut Elitnaurviat School, and Ayaprun School. The next illustration in Figure 24 shows the total child school enrollment for all grades (through 12th grade) at the school shown using NCES data (Common Core of Data, Public Elementary-Secondary School Universe Survey.) Looking at Enrollment for Area Schools we find that Hooper Bay School ranks the largest with a value of 399 enrolled students. The next largest values are for: Chevak School (307), Scammon Bay School (217), Nelson Island Area School (203), and Chief Paul Memorial School (191). The difference between the highest value (Hooper Bay School) and the next highest (Chevak School) is that the enrolled students is about 30.0% larger.
Figure 25 show the ratio of the number of students to the number of teachers in the classroom. A good student to teacher ratio should be low because it indicates that there are less students for any one teacher to educate in a class and generally a better learning environment, better success and optimal teaching excellence. Teachers includes all educational staff such as special education teachers and any other educator. Note that distance learning (online learning/remote learning) is not included in these values. Looking at Student to Teacher Ratio for Area Schools we find that Nuniwarmiut School ranks the largest with a value of 11.2 student to teacher ratio. The next largest values are for: Akiuk Memorial School (12.6), Scammon Bay School (12.8), Paul T. Albert Memorial School (12.8), and Chevak School (12.8). The difference between the lowest value (Nuniwarmiut School) and the next lowest (Akiuk Memorial School) is that the student to teacher ratio is 12.2% larger.
The next chart, Figure 26, shows the racial mix of students at each location in this district of the state of Alaska department of education.
Zip code 99630, Alaska Education Data
Figure 1: 99630, AK At least High School Education
Figure 2: 99630, AK Bachelors Degree or Better Education
Figure 4: 99630, AK School Dropout Rate
Figure 5: 99630, AK Education Attainment Breakdown
Figure 7: 99630, AK Bachelors Degrees Field of Study
Figure 8: 99630, AK Bachelors Degree Obtained
Figure 9: 99630, AK Education Attainment by Level Comparison (Age 25+)
Figure 10: 99630, AK Education Attainment Detailed Comparison (Age 25+)
Figure 11: 99630, AK Detailed Education Attainment Breakout by Age Group (Age 18+)
Figure 12: 99630, AK Detailed Education Attainment Breakout by Race (Age 25+)
Figure 13: 99630, AK Detailed Male and Female breakdown of Educational Attainment
Figure 14: 99630, AK School Enrollment by Aggregate Categories
Figure 15: 99630, AK Overall Public vs. Private School Enrollment
Figure 16: 99630, AK Public vs. Private K-8 School Enrollment
Figure 17: 99630, AK Public vs. Private High School Enrollment
Figure 18: 99630, AK Public vs. Private College Enrollment
Figure 19: 99630, AK Public vs. Private Graduate or Professional School Enrollment
Figure 20: 99630, AK Total Enrolled in Schools
Figure 22: 99630, AK Public vs. Private Preschool
Figure 23: List of Schools in the 99630, AK Area (2013)
Figure 24: 99630, AK School Enrollment (2013)
Figure 26: 99630, AK School Racial Mix (2013)
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1 Then the LORD said to Moses, 2 "Set up the Tabernacle  on the first day of the new year.  3 Place the Ark of the Covenant  inside, and install the inner curtain to enclose the Ark within the Most Holy Place. 4 Then bring in the table, and arrange the utensils on it. And bring in the lampstand, and set up the lamps.
5 "Place the gold incense altar in front of the Ark of the Covenant. Then hang the curtain at the entrance of the Tabernacle. 6 Place the altar of burnt offering in front of the Tabernacle entrance. 7 Set the washbasin between the Tabernacle  and the altar, and fill it with water. 8 Then set up the courtyard around the outside of the tent, and hang the curtain for the courtyard entrance.
9 "Take the anointing oil and anoint the Tabernacle and all its furnishings to consecrate them and make them holy. 10 Anoint the altar of burnt offering and its utensils to consecrate them. Then the altar will become absolutely holy. 11 Next anoint the washbasin and its stand to consecrate them.
12 "Present Aaron and his sons at the entrance of the Tabernacle, and wash them with water. 13 Dress Aaron with the sacred garments and anoint him, consecrating him to serve me as a priest. 14 Then present his sons and dress them in their tunics. 15 Anoint them as you did their father, so they may also serve me as priests. With their anointing, Aaron's descendants are set apart for the priesthood forever, from generation to generation."
16 Moses proceeded to do everything just as the LORD had commanded him. 17 So the Tabernacle was set up on the first day of the first month of the second year. 18 Moses erected the Tabernacle by setting down its bases, inserting the frames, attaching the crossbars, and setting up the posts. 19 Then he spread the coverings over the Tabernacle framework and put on the protective layers, just as the LORD had commanded him.
20 He took the stone tablets inscribed with the terms of the covenant and placed them  inside the Ark. Then he attached the carrying poles to the Ark, and he set the Ark's cover—the place of atonement—on top of it. 21 Then he brought the Ark of the Covenant into the Tabernacle and hung the inner curtain to shield it from view, just as the LORD had commanded him.
22 Next Moses placed the table in the Tabernacle, along the north side of the Holy Place, just outside the inner curtain. 23 And he arranged the Bread of the Presence on the table before the LORD, just as the LORD had commanded him.
24 He set the lampstand in the Tabernacle across from the table on the south side of the Holy Place. 25 Then he lit the lamps in the LORD's presence, just as the LORD had commanded him. 26 He also placed the gold incense altar in the Tabernacle, in the Holy Place in front of the inner curtain. 27 On it he burned the fragrant incense, just as the LORD had commanded him.
28 He hung the curtain at the entrance of the Tabernacle, 29 and he placed the altar of burnt offering near the Tabernacle entrance. On it he offered a burnt offering and a grain offering, just as the LORD had commanded him.
30 Next Moses placed the washbasin between the Tabernacle and the altar. He filled it with water so the priests could wash themselves. 31 Moses and Aaron and Aaron's sons used water from it to wash their hands and feet. 32 Whenever they approached the altar and entered the Tabernacle, they washed themselves, just as the LORD had commanded Moses.
33 Then he hung the curtains forming the courtyard around the Tabernacle and the altar. And he set up the curtain at the entrance of the courtyard. So at last Moses finished the work.
34 Then the cloud covered the Tabernacle, and the glory of the LORD filled the Tabernacle. 35 Moses could no longer enter the Tabernacle because the cloud had settled down over it, and the glory of the LORD filled the Tabernacle.
36 Now whenever the cloud lifted from the Tabernacle, the people of Israel would set out on their journey, following it. 37 But if the cloud did not rise, they remained where they were until it lifted. 38 The cloud of the LORD hovered over the Tabernacle during the day, and at night fire glowed inside the cloud so the whole family of Israel could see it. This continued throughout all their journeys.
<< 40:2a Hebrew the Tabernacle, the Tent of Meeting; also in 40:6, 29. 40:2b Hebrew the first day of the first month. This day of the ancient Hebrew lunar calendar occurred in March or April.
<< 40:3 Or Ark of the Testimony; also in 40:5, 21.
<< 40:7 Hebrew Tent of Meeting; also in 40:12, 22, 24, 26, 30, 32, 34, 35.
<< 40:20 Hebrew He placed the Testimony; see note on 25:16.


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Region: Land-Rich Developed Countries
The Population of Cleveland in 2013 was 1,865,023, increasing at an average annual rate of 1.1% since 2000. The population of Cleveland in 2000 was 1,622,727, increasing at an average annual rate of 1.7% since 1990, when its population was 1,376,230.
The Urban Extent of Cleveland in 2013 was 192,157 hectares, increasing at an average annual rate of 3.3% since 2000. The urban extent in 2000 was 124,807 hectares, increasing at an average annual rate of 4.6% since 1990, when its urban extent was 79,395 hectares.
Built-up Area Density in Cleveland in 2013 was 16 persons per hectare, decreasing at an average annual rate of -2.5% since 2000. The built-up area density in 2000 was 22 persons per hectare, decreasing at an average annual rate of -3.4% since 1990 when the built-up area density was 31.33 persons per hectare.
The Urban Extent Density in Cleveland in 2013 was 10 persons per hectare, decreasing at an average annual rate of -2.2% since 2000. The urban extent density in 2000 was 13 persons per hectare, decreasing at an average annual rate of -2.9% since 1990 when the urban extent density was 17 persons per hectare.
A total of 44,156 hectares of built-up area was added to the Cleveland urban extent between 2000 and 2013. Of that added built-up area, 36% was Infill, 30% was Extension, 0% was Leapfrog, and 34% was Inclusion. A total of 28,764 hectares of built-up area was added to the urban extent between 1990 and 2000. Of that added built-up area, 40% was Infill, 39% was Extension, 0% was Leapfrog, and 21% was Inclusion.
Average road width in the Cleveland 1990-2014 expansion area was 21.76 meters, compared to 10.82 meters in its pre-1990 area.
The share of built-up area in Cleveland occupied by roads in the 1990-2014 expansion area was 16%, compared to 19% in the pre-1990 area.
The density of arterial roads in Cleveland's 1990-2014 expansion was 1.21 km/km2, compared to 1.63 km/km2 in its pre-1990 area.
The share of built-up area within walking distance of an arterial road in Cleveland's 1990-2014 expansion area was 91%, compared to 95% in the pre-1990 area.
Average block size in Cleveland's 1990-2014 expansion area was 7.7 hectares, compared to 5.3 hectares in its pre-1990 area.