Description Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.
1. Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells. Tumour Biol. 2013 Jun;34(3):1935-47. doi: 10.1007/s13277-013-0738-7. Epub 2013 Mar 22.
The combination therapy of lomeguatrib and TMZ decreased MGMT expression, increased p53 expression and DNA fragmentation and induced apoptosis in primary GBM cell cultures and glioma cell lines without affectinf MGMT methylation and cell cycle, where the sensitivity to the therapy was associated with the structure of MGMT methylation.
2. Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination. Mol Biol Rep. 2014 Feb;41(2):697-703. doi: 10.1007/s11033-013-2908-5. Epub 2013 Dec 25.
The combination of lomegutrin and TMZ decreased MGMT expression, increased p53 expression and induced apoptosis without affecting cell cycle in AA cell lines, where lomeguatrib enhanced the anti-AA activity of TMZ.
3. Inhibition of DNA repair with MGMT pseudosubstrates: phase I study of lomeguatrib in combination with dacarbazine in patients with advanced melanoma and other solid tumours. Br J Cancer. 2011 Sep 6;105(6):773-7. doi: 10.1038/bjc.2011.285. Epub 2011 Aug 2.
The combination of lomeguatrib, which depletes MGMT, and dacarbazine has been assessed in a phase I trial.
4. A phase I trial of lomeguatrib and irinotecan in metastatic colorectal cancer. Cancer Chemother Pharmacol. 2010 Oct;66(5):829-35. doi: 10.1007/s00280-009-1225-0. Epub 2009 Dec 29.
The combination of lomeguatrip and irinotecan has been assessed for MTD, safety, toxicity and clinical pharmacology in patients with metastatic cancer.
5. Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib. Clin Cancer Res. 2010 Jan 15;16(2):743-9. doi: 10.1158/1078-0432.CCR-09-1389. Epub 2010 Jan 12.
The minimal dosage of lomeguatrib to neutralize MGMT activity for 12 hours has been determined in patients with prostate, CNS and colorectal cancer.
Lomeguatrib is an O6-methylguanine-DNA-methyl-transferase (MGMT) inhibitor , with an IC50 value of about 6 nM to inactivate MGMT in MCF-7 cells, effectively .
MGMT activity is closely related to MTIC (a metabolite of dacarbazine)-mediated DNA damage .
Lomeguatrib sensitized MGMT-activity-bearing A375P cells to temozolomide (TMZ), but it failed to affect the effect of dacarbazine (DTIC). In other mutBRAF cells and several mutNRAS cell lines such as WM1361, similar results were obtained .
With one exception, patients treated with lomeguatrib showed no active or very low MGMT in PBMCs. Lomeguatrib at a dose of 20 mg resulted in 16.7 fmol/μg DNA active MGMT in a CNS-tumor-bearing patient. This patient showed a percentage of 25% for inactive tumor MGMT. This percentage was lower than that in the other two CNS patients with lomeguatrib at the same dose. Different tumor types showed remarkable differences in total tumor MGMT. Prostate cancers had the highest (554 ± 404 fmol/mg protein), CNS tumors had the lowest (89.9 ± 44.5 fmol/mg protein), and colorectal tumors had intermediate levels of total protein (244 ± 181 fmol/mg protein). In the colorectal cancer, the primary CNS tumor, and the prostate cancer of patients, increasing lomeguatrib doses resulted in increasing inactive MGMT proportions .
. Imanol Arozarena, Ibai Goicoechea, Oihane Erice, et al. Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. Molecular Cancer, 2014, 13:154.
. M Clemons, J Kelly, AJ Watson, et al. O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. British Journal of Cancer, 2005, 93:1152-1156.
. Amanda J. Watson, Ami Sabharwal, Mary Thorncroft, et al. Tumor O6-methylguanine-DNA Methyltransferase Inactivation by Oral Lomeguatrib. Clinical Cancer Research, 2010, 16(2):743-9.


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Youth/Club
Sweetlax Hires Brett Queener to Launch Gulf Coast Program
Written on February 6, 2019 . Posted in Club, Featured Posts, Florida Lacrosse News, Youth Instruction, Youth/Club.
via press release
NAPLES, FL – Sweetlax is excited to announce that Brett Queener will be joining their Florida staff as the Director of Coaching & Player Development for the Gulf Coast Wahoos, a new Naples-based Regional Development Program (RDP). In this position Queener will oversee the formation of club teams and the addition of player development programming aimed as serving local lacrosse communities up and down the Gulf Coast. Queener will also serve as a goalie coach for our Sweetlax Florida teams.
"We are excited to welcome Brett to the Sweetlax family. He is an extremely talented young coach and his passion for the game is contagious," said Kevin Martin, Sweetlax co-founder and Director of College Recruiting. "Coach Queener has already had a very positive impact on the Gulf Coast lacrosse community; We are very lucky to have him on our team."
Queener, a former All-American goalie at the University of Albany, has an impressive resume, but more importantly, has proven himself as an inspiring teacher of the game. Brett Coaches with an unmatched spirit and passion that brings out the best in his players.
Quick Highlights from Queeners Resume:
6 Time MLL All Star
DI player UAlbany
2 Time MLL Champion
2 Time Inside Lacrosse Personality of the Year
4 Year NLL Player
DI Coach : Syracuse / UAlbany : 3 Final Fours / 2 National Finals
Certified Organic Farmer
About the Wahoos:
The Wahoos are a newly launched Regional Development Program of Sweetlax Florida. We seek to help lacrosse players in the Gulf Coast region realize their full potential, on and off the field.
Tryouts for the Wahoos 2019 Summer Club Teams will take place on President's Day, February, 18th. You can register for tryouts here.
Tryout Times & Age Groups:
12:00 – 2:00 PM, U8* (1st/2nd Grade) & U10* (3rd/4th Grade)
2:00 – 4:00 PM, U12 (5th/6th Grade) & U14 (7th/8th Grade)
4:00 – 6:00 PM, High School A & B (All HS Grades)
Program Highlights:
3 Summer Tournaments (Dates & Events TBA at Tryouts)
10-12 Practices
Recruiting & College Placement Support for HS players
*The U8 and U10 practice and event schedule will be modified and age appropriate.

redpajama_set_name: RedPajamaCommonCrawl


The PIKE U Scholarship Program is a vital component of PIKE U. The scholarship program provides direct support for Pi Kappa Alpha chapters and colonies to encourage participation in PIKE U events.
Each chapter and colony has a scholarship account to help offset registration costs for PIKE U events (Leadership Summits, The Academy, Chapter Executive Conference, and Convention).
While completing the online registration, select the "PIKE University Scholarship Fund" option as your method of payment. Done. It's as simple as that! Post event, a chapter/colony may request reimbursement from their respective PIKE U scholarship account up to the total registration costs for the event. Post-event requests must be completed within 60 days of the close of the event. Contact the event coordinator at pikeuniversity@pikes.org for more information.
Additionally, a minimum of $250.00 is allocated to each chapter/colony on July 1 by the International Fraternity each year to help brothers attend PIKE U .
The PIKE Foundation maintains an endowment account for each chapter. After an account reaches $10,000 in donations, members of that chapter may receive an annual grant to their scholarship account, based on a percentage of the account's balance to attend Pike U events. Note: An endowment is a fixed amount of money that earns interest and provides a distribution from the interest earned. The corpus will grow over time with contributions and positive market returns resulting in a larger distribution amount, but the distribution is a percentage of the corpus.
Ask all student members to join φφκα.
Encourage alumni to make a designated, tax-deductible gift to the PIKE Foundation for your Chapter Endowment Fund.
Encourage parents and grandparents to make a designated, tax-deductible gift to the PIKE Foundation for your Chapter Endowment Fund.
Chapters that meet the criteria for the annual recruitment incentives may earn additional PIKE U scholarship funds. Please contact the Director of Membership Growth for more information.
Many of the international awards include merit-based PIKE U scholarship money. NOTE: Scholarship Amounts are subject to change.
To learn more about your chapter's endowment fund, contact Ginny Stalker at gstalker@pikes.org or 901-748-1948, ext. 141.


text:
Eridani's Crown by Alex Shvartsman
Issue: 3 February 2020
In the world of Eridani's Crown, there are no handy crutches for the reader to rest on. From its earliest pages, Alex Shvartsman's novel subverts many of the tropes of high fantasy. We still get prophecies, politics, warfare, magic, and fantastic creatures, but Shvartsman toys with our expectations at every turn. We follow the titular Eridani's journey from somewhat coddled princess to Queen Mother of the world, and along the way we're subject to treatises on how easily idealism is subverted, on how stories change depending on who is telling them—and on what the teller wants us to hear.
Early in the book—after she has killed her first man (in self-defense during a royal assassination attempt), but while she's still fairly innocent and idealistic—Eridani encounters the Sorceress of Skond and hears the first of several prophecies about her life. She has a complex and ambiguous destiny and everyone except her brother Danchu will come to betray her. As presented, there's none of the traditional craft associated with prophecies in fantasy novels: no investigation of animal innards or use of cards, no trance states or flashes of magic with glimpses of a greater unseen world. It's a simple moment between two women, one of whom is believed to hold mystical power and the other of whom in the moment feels powerless. Nothing in the scene precludes or confirms the presence of the Sorceress's "invisible deity," from whom she claims the prophecy comes. Eridani doubts, the Sorceress certainly sounds like she believes, and the reader is left to decide whether the Sorceress has access to magical means of divination or is just a masterful manipulator. Eridani expects betrayal at every turn, but also hopes that the wording of the prophecy gives her more than one dependable out. Does the prophecy come true because people choose to betray Eridani, or do people betray Eridani because the prophecy is true? There's also a very sly repeating undercurrent about what really constitutes a "betrayal" versus poor judgement. Shvartsman subverts the prophecy trope by never actually confirming whether the prophesier has any actual ability to see the future or is just playing odds based on local politics.
And what politics there are. The book opens with the opportunistic assassination of Eridani and Danchu's parents (and the attempted … kidnapping? murder? … of the siblings), in a bold power-grab by a man with the title of Patriarch. Almost immediately, powerful nobles take sides, most arrayed against the siblings in favor of the entrenched Patriarch. There are secret meetings, offers, counter-offers, and of course the betrayal of promises from that moment on. At first, Eridani is a pawn; later she is the chess master. This through-line is almost a master class in how young, idealistic politicians are slowly chipped away at and lose that idealism. Some get caught up making small concessions to gain support, but those concessions become a trap from which the only way out is more concessions, more backsliding on promises to the people they vowed to represent. Some simply want power or fame or to craft a legacy regardless of the cost. But payment comes due for everyone eventually, and especially for someone who thoroughly loses touch with where they started.
In high fantasy, politics almost always leads to warfare, and this is especially so in the Grimdark sub-genre. There is no shortage of bloody battles throughout the book, from Eridani's first swordfight through the solo battles that build her legend. But here again, Shvartsman plays with expectations: the bigger the battles get, the more removed from them Eridani becomes. There's more bloodshed in the second half of the book than the first, but our main character no longer experiences it firsthand. Instead, Shvartsman introduces a tertiary-level character to keep readers informed about the toll Eridani's destiny is taking on the average person. Here, the author cleverly inserts a bit of previously published flash fiction, "The 47 Dictums of Warfare," as a chapter that brutally reveals the impact constant warfare has on the rank and file, and what place honorable behavior might have in such a world.
Amid this careful unspooling of consequence, it's only about halfway through that we get any sense that magic might be real in this world. Shvartsman uses magic sparingly throughout the book, and it first appears through the presence of a giant bat-like creature which Eridani encounters. Even here and afterwards, the magic itself is mentioned but never becomes a focal point. Likewise, there's a warlock in Eridani's court and we see the toll magic takes on it as it becomes less human as the story unfolds, but we never learn why the magic has this effect on it. Eridani herself never wields magic (although she does take possession of what seems to be a legendary sword), while the Sorceress seems to employ magic in one of her later appearances but even that might be adept sleight of hand. Even in George R. R. Martin's A Song of Ice and Fire, magic and fantastical creatures eventually came to the forefront of the narrative; here, they never really do. Another expectation turned sideways.
Another common characteristic of high fantasy is inordinate length. There's a lot of landscape—both figurative and literal—to cover for Eridani's story to be complete. In some hands, this story would have topped a thousand pages, and in others it would stretch across a multivolume series of novels of ever-increasing girth. Shvartsman gives it all to us in a lean 284 pages, leaping first months then years in Eridani's life and letting light exposition fill in what we haven't seen. Not every dress worn, sword wielded, battlement stormed needs to be detailed to understand the world in which Eridani lives and which she irrevocably alters. There's not a wasted word in this book, and therefore every word is a signpost to one of the novel's themes.
One of those themes is that power corrupts. It's a cliché, with good reason, and here, too, Shvartsman undermines the trope: absolute power doesn't necessarily corrupt absolutely. Eridani starts out idealistic; she draws people to her because she does the right thing, if not always for the right reasons. This is true only for so long in the novel, however, before we see Eridani starting to change her goals and her reasons for pursuing them. There is plenty of evidence that Eridani is pained by the decisions she makes, regrets the results of those decisions. Power corrupts, but it may not corrode.
The novel's other major theme is that stories and facts can be manipulated to prove a point. Even if the Sorceress of Skond's prophecy is a true telling and not just intentional vaguery, what she chooses to tell Eridani—and what she chooses to leave unspoken—affect how Eridani acts from that point forward. Had Eridani been given more detail about who exactly would betray her or how, for instance, she might have interpreted certain characters' actions less as betrayal and more as honest mistakes. Similarly, and later in the novel, Eridani and her council encounter a subversive storyteller, a woman who uses language and colored smoke to relate the legend of Kalatar, a figure who once united much of the world under a single ruler. The storyteller manipulates the facts and even geography of Kalatar's story to make a very specific point about the nature of conquest and rulership, much as modern movie and theater directors pick and choose which details of a famous person's life to highlight in a biographical work (see the ongoing controversy over Lin-Manuel Miranda's Hamilton, for instance). The same storyteller is later convinced to tell Eridani's story in a way that presents her as beneficent ruler rather than brutal conqueror, despite much evidence to the contrary. To take it to a more meta level, Shvartsman himself leaves swathes of Eridani's life out of the narrative and leaves unresolved the reality and strength of magic. I think what's left out is intentional, to drive us to see Eridani in a certain light, and to take certain lessons from her story.
In the first half of the book, almost everything that happens to Eridani is out of her control: the death of her parents, the loss of key supporters. In the second half of the book, she reacts to that early lack of control by swinging too far in the other direction. Always afraid that what she has will be taken away from her, she loses sight of her youthful goals and becomes someone very different from the woman she thought she would grow into. Like the subversive Storyteller, Shvartsman uses only the moments of Eridani's life that illustrate how change in a personality, or in a person's goals and aspirations, happens so incrementally that we don't see it in ourselves—or that if we do, we often see it too late.
© Copyright 2020 By: Anthony Cardno
About Anthony Cardno
Anthony R. Cardno's reviews have also appeared in Icarus and Chelsea Station . His short fiction can be found in Beyond the Sun (Fairwood Press) and Oomph (Crossed Genres). He interviews creative types at www.anthonycardno.com and can be found on Twitter as @talekyn.


The class presents company officers and firefighters with the information necessary to accurately assess the fire potential in the dynamic wildland fire environment and to establish corresponding tactical decision points to enhance crew safety. The focus is on identifying the critical ingredients of extreme fire behavior potential, setting tactical decision points to enhance crew safety while engaged, and a systematic approach to the constant evaluation of situational awareness before and during tactical assignment. Critical elements of fire behavior and spatial awareness topics are covered in a concentrated and operational-based format for immediate use by firefighters.
The class will utilize lecture with supporting PowerPoint presentation, photographs and videos to deliver critical situational awareness and life safety skills for Company Officers in the Wildland Fire Environment. A scenario based training situation will be delivered for students to demonstrate their skills of critical decision making and fire potential recognition.


Mini Nyan Cat and more!
This post may contain referral/affiliate links. Please read my disclosure for more info.
I have lots of fun things going on! I have this little Nyan Cat project that I'm working on now that the quilt is finished (yes, it is done!). I'll show you the quilt once this little piece is done.
Saturday this beautiful bundle of fabrics came in the mail…..thank goodness we were already gone or I may have decided to just stay home and play with them!
This adorable collection called Happy Town was specially designed by Jacquelynne Steves of The Noble Wife. This collection was designed to help support the beautiful and growing outreach of Quilts for Kids!
You'll be seeing more of this as I'm going to make several projects and I will be sharing some of these fabrics in a giveaway.
The Noble Wife is my newest sponsor and I really look forward to working with her beautiful designs! She also has a giveaway on her blog that ends tonight so if you haven't entered…..you'd better visit her blog.
I also had this beautiful bundle of red fabrics and a pattern in the mail that I won from Patrica of Dogwood Lane Rambles during her recent blog anniversary. Thanks so much Patrica!
The Hugs & Kisses blog hop starts today and here is a little peek at my project. Tomorrow is my day on the schedule and I can't wait! Because of this I will start Linky Tuesday later this afternoon and of course you can always find it on the Linky Party Tuesday page.
Be sure and stop by Patchwork Times to see what others are working on.
Love the Nyan and the fabrics!! How fun!
I can't wait to see your blog hop entry either!
I love your gorgeous fabrics. Can't wait to see what you make with them.
Your fabrics are beautiful, and I love the Courthouse Steps block.
Aren't those fabulous fabrics? They will be so much fun to play with.
I.m looking forward to your special day.
Visit my shops at My Store or at Etsy or at Craftsy for quilt patterns.
Some of the links on this site are affiliate links and I may be compensated a small commission when you make a purchase by clicking on those links. I only promote products and services that I use and love myself. Your support enables me to maintain the content of this blog and I am truly grateful!


STANFORD, Calif. (AP) — Stanford's Chiney Ogwumike has become the first player to win Pac-12 Player of the Year and Defensive Player of the Year in the same season.
The conference also announced Tuesday that Stanford's Tara VanDerveer won coach of the year for the 13th time in her Hall of Fame career. Colorado's Arielle Roberson earned Pac-12 Freshman of the Year honors.
The conference's coaches vote on the awards.
Ogwumike is averaging 22.9 points and 12.7 rebounds while shooting 59 percent for fourth-ranked Stanford (28-2). She also won defensive player of the year last season.
Her older sister, Nneka Ogwumike, twice won Pac-12 Player of the Year — including last season. She now plays for the WNBA's Los Angeles Sparks.


Stunning two bedroom semi-detached cottage in a popular residential area.
Part Exchange Available - We are delighted to offer for sale this well maintained two bedroom semi-detached sandstone villa. The property has recently undergone a refurbishment and modernisation program and is offered to the market in fantastic decorative order. Properties of this type and nature come to the market very rarely. The combination of the older style, with its good looks and character, coupled with the neutral interior, will attract a variety of potential purchasers looking for their ideal home.
Formed over two levels the property consists of: a welcoming reception hallway. Immediately impressive bright and airy lounge/kitchen/dining area, with French doors to the rear aspect which floods the room with natural light. The kitchen area includes a good range of floor and wall mounted units with a striking worktop, which provides a fashionable and efficient workspace, making this the ideal kitchen for an aspiring chef. A large family shower room can also be found off the hall and includes a modern three piece suite. Finally downstairs there is the second bedroom it has a fitted wardrobe and window to the front of the property.
The upper accommodation comprises of a small landing area which gives you access to the large master bedroom with dormer window with the added bonus of beautifully installed en-suite.
For additional comfort, this family home benefits from both double glazing and oil central heating. Externally, there is a low maintenance rear garden which has a slabbed patio, chipped area, water feature and storage sheds.
Extras (Included in the sale) All floor coverings and integrated appliances.


"Almost 90% of Events are not secured", this statement came out when a research carried out on different events, which took place in Delhi, NCR and other places.
But, this above mentioned statement can be proved if the event planners, producers and organizers consider Security Service Event and Crowd Control Security Services. Event industry has its own style, it is totally unlike other industries, whether it is a concert, award show, festival, political party, tradeshow, they come up with a new idea and present something unique. It does not matter, whether the event is big or small, it remains exposed to risk all the time and requires safety, security, legal and financial considerations.
Secura Security provides best armed and unarmed security guards for Security Service for Events and Crowd Control Security as per the requirement of event organizers, producers and planners. The Security Guards provided by them for event security addresses the safety of planners, crowd, organizers, venue, etc. Provision of both male and female security guards is provided by them for Security Service Event. The organizers, planners and investors can choose the one which is required.


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Whether you are on your way to the bakery or the finish line – if you are on a bike, you are part of the ever-growing global family of two bilion cyclists. ŠKODA has been supporting this family since its founding day in 1895 and this year marks the 18th anniversary of our sponsorship of the Tour de France.
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Egan Bernal Firmly in the Lead of the Giro and Other Cool News from the World of Cycling
Another Monday is here, and so is our news from the world of cycling. So, what did you miss? Campenaerts […]
By Monica Buck May 24, 2021 at 12:05 pm 4 min reading
Another Monday is here, and so is our news from the world of cycling. So, what did you miss?
Campenaerts wins stage 15
Already the eighth time the breakaway managed to hold off the peloton at this year's Giro d'Italia and it was the hour-record holder Victor Campenaerts (Qhubeka Assos) who proved to be the strongest in the end. He outsprinted Oscar Riesbeek (Alpecin-Fenix) after the pair broke away from the rest of the escapees before the last climb. The peloton came across the line 17 minutes later. All the GC contenders allowed themselves a break before today's big test ending in Cortina d'Ampezzo.
So proud of you Beasty @VCampenaerts ❤ #WEareBack #Ubuntu https://t.co/KDK07grkCT
— Miss Lecluyse (@FannyLecluyse) May 23, 2021
Giro d'Italia 2021 – stage 15
Victor Campenaerts (Qhubeka-Assos) – 3:25:25
Oscar Riesbeek (Alpecin-Fenix)
Nikias Arndt (DSM) + 7s
Simone Consonni (Cofidis)
Quinten Hermans (Intermarché-Wanty-Gobert-Matériaux)
Dario Cataldo (Movistar)
Bauke Mollema (Trek-Segafredo) + 9s
Albert Torres (Movistar) + 44s
Juan Sebastián Molano (UAE Team Emirates) + 1:02
Max Walscheid (Qhubeka-Assos)
Egan Bernal (Ineos Grenadiers) – 62:13:33
Simon Yates (BikeExchange) + 1:33
Damiano Caruso (Bahrain-Victorious) + 1:51
Aleksandr Vlasov (Astana-Premier Tech) + 1:57
Hugh Carthy (EF Education-Nippo) + 2:11
Giulio Ciccone (Trek-Segafredo) + 3:03
Remco Evenepoel (Deceuninck – Quick-Step) + 3:52
Dani Martínez (Ineos Grenadiers) + 3:54
Romain Bardet (DSM) + 4:31
Tobias Foss (Jumbo-Visma) + 5:37
Too true?
Visual representation of Bernal following Ganna's slipstream. pic.twitter.com/plDVL6oifS
— Alex Dowsett (@alexdowsett) May 19, 2021
A post shared by We Love Cycling (@wlcmagazine)
We're all old
Asked who his cycling hero was when he was growing up, Attila Valter's answer was Peter Sagan.
I don't think I've ever felt older.
— Cillian Kelly (@irishpeloton) May 16, 2021
This is, uh… an interesting taste
I don't think any of us have ever doubted Froome's ability to suffer, but some of this is next level. pic.twitter.com/keOyqrDBL6
— Daniel Lloyd (@daniellloyd1) May 16, 2021
2021 Giro Cycling News Egan Bernal Giro d'Italia Oscar Riesbeek Victor Campenaerts
Written by: Monica Buck
Recumbents – Why Haven't You Tried Riding One?
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In 2010, I began my education at Calvin College. I graduated from Calvin College in January 2014 with a Bachelor's degree in Elementary Education and minors in Mathematics and Language Arts. I have returned to Calvin College and will be completing my Master's degree in Education and Literacy.
This will be my fifth year in the wonderful community at Dutton Christian School.
In my free time, I love spending time with my friends and family. I also enjoy reading, learning about healthy & wellness, and traveling. I have friends all over the state, and frequently go on weekend excursion to visit. I have also been all over Europe, and recently returned from a trip to Prague. I am a member at Encounter Church.
I love kids, I love teaching, and I love the Lord. I have been part of Christian education as both a student and teacher since I was very young. I truly see the value of being in a Christian community that strives to educate with a Christ-centered worldview. I had the opportunity to aid in several public school settings during my time at Calvin, and I realized the incredible difference that not only a Christian education, but also a Christian community can make. I love having the opportunity to share and discuss my faith with students, parents, and colleagues.
Faith is an integral part of everything that I do in the classroom. One way that I have seen faith impact students is through the use of prayer. The students share their prayer requests every morning during our devotion time, and I encourage students to pray throughout the day for one another and the things happening in their lives, whether big or small. I have seen students in my classes stop and pray for one another as they share the illness of a family member. I have prayed with students as they resolve conflicts and work to forgive and reconcile with their classmates. I have had students come and ask if I will pray with them just because they are having a rough day. I love incorporating prayer into the classroom and have seen the amazing impact it can have on the lives of the students, their relationships and community with each other, and their relationship with the Lord.
I was a ballet dancer for nine years.


An octagonal shaped platinum ring set with an old cut diamond, surrounded by square cut emeralds and sapphires; diamonds on shoulder. Second-hand ring.
Total weight 7 grams Finger size "N". We can resize the ring professionally for no extra cost.


Safety | Lyon-Lincoln Electric Cooperative, Inc.
At Lyon-Lincoln Electric Cooperative, the safety of our employees, members, and the general public is important to us. The following information is meant to keep you and your family safe, and possibly save a life.
Accidentally touching a power line can be dangerous and even deadly. Lyon-Lincoln wants our members to stay safe around power lines.
Whether you are working outdoors on a landscaping project or playing with your children, keep a safe distance away from power lines and other electrical equipment used to get electricity to your home.
Stay away from power lines, transformers, meters and electrical boxes.
If you get something stuck in a power line, call Lyon-Lincoln immediately.
Keep a safe distance away from power lines when working with a ladder.
Never touch anything that may be in contact with a downed power line, such as a tree or car.
Keep children and pets away from downed power lines.
Remember power lines can also be buried underground, so always "Call Before You Dig"- dial 811 from any phone and utility workers will come out and check the area for underground lines before you dig.
If a power line falls on a car, you should stay inside the car. Warn others outside the vehicle not to touch it or the power line and for them to stay a safe distance away. Call 911 immediately. The only circumstance where you should get out of the vehicle is if it is on fire. DO NOT step out of the vehicle but JUMP FREE of the vehicle, so that your body clears the vehicle before touching the ground. Electricity spreads out through the ground in ripplies, like a stone dropped in water. The voltage is highest in the ring closest to the vehicle and decreases with distance. Hop with feet together so that one foot won't be in a higher voltage zone than the other, which could make you a conductor for electricity.
Make sure fire detectors and carbon monoxide detectors are in good working condition.
Keep space heaters at least 3 feet from anything flammable and never leave unattended.
Place space heater on level, hard, non-flammable floor service - never on carpet, furniture or counter.
Do not overload circuits. Never use extension cords or multiple plugs with a space heater.
Before using an electric blanket, check for any damage to the blaket and cord.
Do not tuck electric blanket under mattress pad and do not place another blanket or comforter on top of it.
Click on the button to the left for more Safety Information.


The Leica Televid 25-50x Variable Asph Zoom Eyepiece is a unique, variable wide-angle eyepiece It has a fantastic field of view across the entire zoom range. The interchangeable bayonet system has an integrated, automatic eyepiece lock, which fixes all eyepieces securely to the scope and thanks to the construction of the optical system, the eyepiece's focal length doesn't change when changing from the 65 mm or 82mm scopes. The eyepiece is rubberised with comfortable rotating eyecups, which significantly increases the comfort factor when viewing for long periods and is waterproof up to 17ft (5m) plus. It has been filled with nitrogen to prevent internal fogging.
This product is covered under the Leica Passport. The Leica Passport scheme applies to new Leica Cameras, Lenses, Binoculars, Scopes and Rangefinders. All items under the Leica Passport Scheme are covered against accidental damage for one year.
If, during this one year cover any part of your Leica product stops working or functions incorrectly, including accidental damage, will be repaired or replaced by Leica - free of charge.
You will receive your Leica Passport Scheme application card along with your order. Simply fill in your details and post back to Leica. Your cover starts from the data of purchase and lasts for one year. Only products purchased from authorised Leica Dealers are covered by the Leica Passport Scheme, within the UK.
We are an Authorised Leica Dealer for Sports Optics, and all of our new Leica products are covered by the Leica Passport Scheme, for UK addresses only.


text:
Q: Codeigniter: delete or change form button style I'm using Codeigniter to build a form.
The submit button is:
echo form_submit('submit', 'Buy it', "id='bred'");

Now I'm processing the form in the same php file that it is:
if (isset($_POST['submit'])) {

    $query = "INSERT INTO table (product, price) VALUES ('$product', '$price')";
    mysql_query($query)
    or die(mysql_error());

//after inserting in the database I need to delete the submit button, so the form cannot be submitted twice

}

After inserting in the database I need to delete/change the css to opacity 0/change the css to display none the submit button, so the form cannot be submitted twice.
How can I do this?
Thanks

A: Except that the way you do isn't save:
Due to "echo" the button you have no possibility to delete it with PHP
A (not very stylish) way would be to echo some JS code that deletes the button.

A: Making use of jQuery will make this easy for you.
You will need to detect the submission of the form and then disable the submit button.
This code assumes that your form and button have the IDs 'myForm' and 'submitButton' respectively.
Javascript:
// Detect the submission of myForm
$('form#myForm').bind('submit', function() {

    // Disable the submit button and fade to half opacity
    $('input#submitButton').attr("DISABLED", true).fadeTo('fast', 0.5);
});

redpajama_set_name: RedPajamaStackExchange


Age : (i) The applicant shall have completed 21 years of age and not more than 35 years of age as on 01.05.2012 (cut-off date).
Selection Procedure : a) Selection will be made on the basis of a written test if necessary, followed by an Interview of candidates who qualify in the written test.
Application Fee (Non-Refundable) : For all candidates (other than SC/ST category): Rs.100/- (Rs. One hundred only). The application fee shall be paid by cash only at the cash counter during cash hours only of any Branch office of Life Insurance Corporation of India under Account Code 114034.


AAPFCO. 2002. Commercial Fertilizer Database, 1990-2002. Association of American Plant Food Control Officials, Division of Regulatory Services, Lexington, KY.
Alexander, R. B., R. A. Smith, and G. E. Schwarz. 2000a. Effect of stream channel size on the delivery of nitrogen to the Gulf of Mexico. Nature 403:758-761.
Alexander, R. B., R. A. Smith, G. E. Schwarz, S. D. Preston, J. W. Brakebill, R. Srinivasan, and P. A. Pacheco. 2000b. Atmospheric nitrogen flux from the watersheds of major estuaries of the United States: an application of the SPARROW watershed model. Pages 119-170 in R. Valigura, R. B. Alexander, M. Castro, T. Meyers, H. Paerl, P. Stacey, and R. E. Turner, editors. Nitrogen loading in coastal water bodies: an atmospheric perspective. American Geophysical Union Monograph.
Barrionuevo, A. 2005. Mountains of corn and a sea of farm subsidies. The New York Times, Business Section, November 9. New York, NY.
Boesch, D. F., and R. B. Brinsfield. 2000. Coastal eutrophication and agriculture: contributions and solutions. In, E. Balazs, E. Galante, J. M. Lynch, J. S. Schepers, J.-P. Toutant, D. Werner, and P. A. T. J. Werry, editors. Biological resource management: Connecting science and policy. Springer, Berlin.
Burkart, M. R., and D. E. James. 1999. Agricultural-nitrogen contributions to hypoxia in the Gulf of Mexico. Journal of Environmental Quality 28:850-859.
David, M. B., L. E. Gentry, D. A. Kovacic, and K. M. Smith. 1997. Nitrogen balance in and export from an agricultural watershed. Journal of Environmental Quality 26:1038-1048.
Diaz, R. J., and R. Rosenberg. 1995. Marine benthic hypoxia: a review of its ecological effects and the behavioural responses of benthic macrofauna. Oceanography and Marine Biology: An Annual Review 33:245-303.
Donner, S. D. 2003. The impact of cropland cover on river nutrient levels in the Mississippi River Basin. Global Ecology and Biogeography 12:341-355.
Donner, S. D., M. T. Coe, J. D. Lenters, T. E. Twine, and J. A. Foley. 2002. Modeling the impact of hydrological changes on nitrate transport in the Mississippi River Basin from 1955-1994. Global Biogeochemical Cycles 16:1-19.
Donner, S. D., and C. J. Kucharik. 2003. Evaluating the impacts of land management and climate variability on crop production and nitrate export across the Upper Mississippi Basin. Global Biogeochemical Cycles 17:11-11 - 11-16.
Donner, S. D., C. J. Kucharik, and J. A. Foley. 2004. Impact of changing land use practices on nitrate export by the Mississippi River. Global Biogeochemical Cycles 18:GB1028.
ERS. 2005. US Fertilizer Use and Price. In United States Department of Agriculture, Economic Research Service, Washington, DC.
ESRI. 2005. ArcMap v. 9.1. in. Environmental Systems Research Institute, Redlands, CA.
EWG. 2004. Agricultural Subsidy Database. in. Environmental Working Group, Washington, DC.
FAO. 2002. Fertilizer use by crop. Food and Agriculture Organization of the United Nations, Rome.
Fenn, M. E., J. S. Baron, E. B. Allen, H. M. Rueth, K. R. Nydick, L. Geiser, W. D. Bowman, J. O. Sickman, T. Meixner, D. W. Johnson, and P. Neitlich. 2003. Ecological effects of nitrogen deposition in the western United States. Bioscience 53:404-420.
Ferm, M. 1998. Atmospheric ammonia and ammonium transport in Europe and critical loads: a review. Nutrient Cycling in Agroecosystems 51:5-17.
FSA. 2004. The Conservation Reserve Program: summary and enrollment statistics. Farm Service Agency, Washington, DC.
Goolsby, D. A., and W. A. Battaglin. 2001. Long-term changes in concentrations and flux of nitrogen in the Mississippi River Basin, USA. Hydrological Processes 15:1209-1226.
Goolsby, D. A., W. A. Battaglin, B. T. Aulenbach, and R. P. Hooper. 2001. Nitrogen input to the Gulf of Mexico. Journal of Environmental Quality 30:329-336.
Goolsby, D. A., W. A. Battaglin, G. B. Lawrence, R. S. Artz, B. T. Aulenbach, R. P. Hooper, D. R. Keeney, and G. J. Stensland. 1999. Flux and sources of nutrients in the Mississippi-Atchafalaya River Basin: Topic 3 Report for the Integrated Assessment on Hypoxia in the Gulf of Mexico. NOAA Coastal Ocean Program Decision Analysis Series No. 17. NOAA Coastal Ocean Program, Silver Spring, MD.
Hey, D. L., and N. S. Philippi. 1995. Flood reduction through wetland restoration: The upper Mississippi River basin as a case history. Restoration Ecology 3:4-17.
IOMA. 2005. Green Markets Dealer Report. September. Pike and Fisher, Silver Spring, MD.
Johnson, D. W. 1992. Nitrogen retention in forest soils. Journal of Environmental Quality 21:1-12.
Justic, D., R. E. Turner, and N. N. Rabalais. 2003. Climatic influences on riverine nitrate flux: Implications for coastal marine eutrophication and hypoxia. Estuaries 26:1-11.
Knops, J. M. H., and D. Tilman. 2000. Dynamics of soil nitrogen and carbon accumulation for 61 years after agricultural abandonment. Ecology 81:88-98.
Lewis, W. M. J. 2002. Yield of nitrogen from minimally disturbed watersheds of the United States. Biogeochemistry 57/58:375-385.
Lins, H. F., and J. R. Slack. 2005. Streamflow trends in the United States. United States Geological Survey Fact Sheet 2005-3017, Reston, VA.
Lohrenz, S. E., G. L. Fahnenstiel, D. G. Redalje, G. A. Lang, X. Chen, and M. J. Dagg. 1997. Variations in primary production of northern Gulf of Mexico continental shelf waters linked to nutrient inputs from the Mississippi River. Marine Ecology Progress Series 155:45-54.
Lovett, G., K. C. Weathers, and W. V. Sobczak. 2000. Nitrogen saturation and retention in forested watershed of the Catskill Mountains, NY. Ecological Applications 10:73-84.
Mann, L. K. 1986. Changes in soil carbon storage after cultivation. Soil Science 142:279-288.
McIsaac, G. F., M. B. David, G. Z. Gertner, and D. A. Goolsby. 2001. Nitrate flux in the Mississippi River. Nature 414:166-167.
McIsaac, G. F., M. B. David, G. Z. Gertner, and D. A. Goolsby. 2002. Relating net nitrogen input in the Mississippi River Basin to nitrate flux in the Lower Mississippi River: a comparison of approaches. Journal of Environmental Quality 31:1610-1622.
Meisinger, J. J., and G. W. Randall. 1991. Estimating nitrogen budgets for soil-crop systems. In, R. Follett, D. R. Keeney, and R. Cruse, editors. Managing nitrogen for groundwater quality and farm profitability. Soil Science Society of America, Madison, WI.
Mitsch, W. J., J. W. J. Day, J. W. Gilliam, P. M. Groffman, D. L. Hey, G. W. Randall, and N. Wang. 1999. Reducing nutrient loads, especially nitrate-nitrogen, to surface water, ground water, and the Gulf of Mexico. Topic 5 Report for the Integrated Assessment on Hypoxia in the Gulf of Mexico. NOAA Coastal Ocean Program, Decision Analysis Series No. 19. NOAA Coastal Ocean Program, Silver Spring, MD.
Mitsch, W. J., J. W. J. Day, J. W. Gilliam, P. M. Groffman, D. L. Hey, G. W. Randall, and N. Wang. 2001. Reducing nitrogen loading to the Gulf of Mexico from the Mississippi River Basin: strategies to counter a persistent ecological problem. Bioscience 51:373-388.
Mississippi River/Gulf of Mexico Watershed Nutrient Task Force. 2001. Action Plan for Reducing, Mitigating, and Controlling Hypoxia in the Northern Gulf of Mexico. Washington, DC.
Moldan, F., and R. F. Wright. 1998. Episodic behaviour of nitrate in runoff during six years of nitrogen addition to the NITREX catchment at Gardsjon, Sweden. Environmental Pollution 102:439-444.
Mueller, D. K., and D. R. Helsel. 1996. Nutrients in the Nation's waters- Too much of a good thing?: U.S. Geological Survey Circular 1136. United States Geological Survey.
NADP. 2000. Nitrogen in the nation's rain. NADP brochure 2000-01b (revised). National Atmospheric Deposition Program, Champaign, IL.
NRC. 2004. Confronting the nation's water problems: The role of research. National Research Council, National Academies Press, Washington, DC.
Perakis, S. S., J. E. Compton, and L. O. Hedin. 2005. Nitrogen retention across a gradient of 15N additions to an unpolluted temperate forest soil in Chile. Ecology 86:96-105.
Rabalais, N. N., R. E. Turner, and D. Scavia. 2002a. Beyond science into policy: Gulf of Mexico hypoxia and the Mississippi River. Bioscience 52:129-142.
Rabalais, N. N., R. E. Turner, and W. J. J. Wiseman. 2002b. Gulf of Mexico hypoxia, A.K.A. "The Dead Zone". Annual Review of Ecology and Systematics 33:235-263.
Scavia, D., D. Justic, and V. J. J. Bierman. 2004. Reducing hypoxia in the Gulf of Mexico: advice from three models. Estuaries 27:419-425.
Scavia, D., N. N. Rabalais, R. E. Turner, D. Justic, and W. J. J. Wiseman. 2003. Predicting the response of Gulf of Mexico hypoxia to variations in Mississippi River nitrogen load. Limnology and Oceanography 48:951-956.
Schils, R. L. M., H. F. M. Aarts, D. W. Bussink, J. G. Conijn, A. M. Corré, A. M. van Dam, I. E. Hoving, H. G. van der Meer, and G. L. Velthof. 2002. Grassland renovation in the Netherlands; agronomic, environmental and economic issues. In, J. G. Conijn, G. L. Velthof, and F. Taube, editors. Grassland resowing and grass-arable crop rotations: Intenational Workshop on Agricultural and Environmental Issues, Wageningen, the Netherlands.
Smil, V. 2001. Enriching the earth. MIT Press, Cambridge, MA.
Smith, R. A., G. E. Schwarz, and R. B. Alexander. 1997. Regional interpretation of water quality monitoring data. Water Resources Research 33:2781-2798.
Stow, C. A., S. S. Qian, and J. K. Craig. 2005. Declining threshold for hypoxia in the Gulf of Mexico. Environmental Science and Technology 39:716-723.
Tetra Tech, Inc. 1998. Documentation of phase I and phase II activities in support of point source nutirent loading analysis in the Mississippi River system. Prepared for USEPA Nonpoint-source Control Branch, contract no. 68-C7-0014., Washington, DC.
Tietema, A., A. W. Boxman, M. Bredemeier, B. A. Emmett, F. Moldan, P. Gundersen, P. Schleppi, and R. F. Wright. 1998. Nitrogen saturation experiments (NITREX) in coniferous forest ecosystems in Europe: a summary of results. Environmental Pollution 102:433-437.
Turner, R. E., N. Qureshi, N. N. Rabalais, Q. Dortch, D. Justic, and J. Cope. 1998. Fluctuating silicate:nitrate ratios and coastal plankton food webs. Proceedings of the National Academy of Science 95:13048-13051.
Turner, R. E., N. N. Rabalais, and D. Justic. 2006. Predicting summer hypoxia in the northern Gulf of Mexico: Riverine N,P, and Si loading. Marine Pollution Bulletin 52:139-148.
Twichell, S., S. Sheldon, L. Deegan, and R. Garritt. 2002. Nutrient and freshwater inputs from sewage effluent discharge alter benthic algal and infaunal communities in a tidal salt marsh creek. Biological Bulletin 203: 256-258.
USDA. 1997. Farm drainage in the United States: History, status, and prospects. Misc. Publ.1455. United States Department of Agriculture, Washington, DC.


text:
Puppy mill research (×)
NY State Senate passes bill to shut down the puppy mill pipeline
NEW YORK—Today, the New York State Senate approved S.1130, to shut down the puppy mill pipeline and end the retail sale of dogs, cats and rabbits in pet stores across the state. Sponsored by Senate Deputy Majority Leader Michael Gianaris (D-Queens), the bill is supported by leading animal welfare...
New federal bill seeks to stop high-speed animal slaughter and meat processing during COVID-19
WASHINGTON—A coalition of animal welfare, consumer safety and worker rights organizations commend U.S. Reps. Marcia Fudge, D-Ohio, Rosa DeLauro, D-Conn., and Bennie Thompson, D-Miss., for introducing the Safe Line Speeds in COVID-19 Act, which would protect workers, animals, and consumers from the...
Speaking out: Young advocate finds her voice
Humane Generation cooks up 2020's hottest culinary trend in Los Angeles
The Golden Globes, the Screen Actors Guild Awards, the Critics' Choice Awards and now the Oscars have made history this year by featuring plant-based-only menus. It seems only natural that LA's young philanthropists would throw themselves into the movement by learning how to prepare plant-based...
Holding food companies accountable
by Matthew Prescott
The problem with plastics
You don't forget the images: the olive ridley sea turtle, a plastic straw lodged in his nose. The Rubenesque sea lion, neck cinched tight by a thick plastic packing strap. The Cuvier's beaked whale, stomach split open to reveal more than 80 pounds of plastic waste—snack bags, rope, rice sacks...
Rampant animal cruelty at California slaughter plant
Video evidence (below) compiled by the Humane Society of the United States shows inhumane handling methods that may have endangered the health of children. A shocking undercover investigation by the Humane Society of the United States reveals widespread mistreatment of "downed" dairy cows—those who...
Abused calves at Vermont slaughter plant
The Humane Society of the United States today released the results of an undercover investigation documenting shocking animal abuse at a Vermont slaughter plant. The U.S. Department of Agriculture and the Vermont Agency of Agriculture took decisive action today based on the information provided by...


text:
Q: Rigorous standardisation of data I have 5 sets of raw experimental data + 1 control set and would like to know what you think about standardising/normalising each set. I want to compare the 5 sets of experimental data to the control set, so my first thought was to divide each data set by the mean $\mu$ of the control data. Would you do this?
Eg. Normalised set 1= set_1/mean(control)
It doesn't seem very rigorous and more importantly why choose this method as opposed to dividing my median, or $\frac{x-\mu}{\sigma^2}$?


When you're looking to get away and not interested in a precise date, take a look at our flight offers this month. Flight deals from Belfast City to Toulouse are great time of year. Be inspired!
Once you have your flight Belfast City-Toulouse booked you can always use lastminute.com to organise the rest of your trip just the way you want it. lastminute.com allows you to book a hotel, car hire, tours and activities in Toulouse.
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text:
Ellen Wright
Ellen has a busy criminal practice acting as both a led junior and junior alone and regularly appears in the Crown Court on a wide range of matters representing clients charged with a variety of offences including murder, fraud, robbery, GBH, drug supply and witness intimidation. Ellen has extensive experience as a trial advocate and is also accustomed to dealing with Serious Crime Prevention Orders, Sexual Risk Orders, Sexual Harm Prevention Orders, Freezing/Forfeiture Orders and Criminal Behaviour Orders.
In addition to her criminal practice, Ellen accepts instructions through the Attorney-General's Junior Panel (formerly the Treasury Solicitor's Baby Barrister Panel) and undertakes work for the Ministry of Defence, the Home Office, the Foreign and Commonwealth Office, Her Majesty's Revenue and Customs and the Serious Fraud Office. Ellen is currently engaged in a significant and highly sensitive regulatory investigation for a band 1, white collar crime firm.
APPOINTMENTS & MEMBERSHIPS
Elected Bar Council Representative
Crown Prosecution Service Panel Advocate Grade 3
Criminal Bar Association
North Eastern Circuit
Young Fraud Lawyers Association
Author, 'Inquests, Article 2 and Covid-19 in Light of Maguire [2020]', Trinity Chambers News & Insights, September 2021 Inquests, Article 2 and Covid-19 in Light of Maguire [2020]
Author, 'Suspicious Activity Reports: The Law Commission's View', Young Fraud Lawyers Association Winter Newsletter, 2019 YFLA Winter Newsletter 2019
Co-author, 'Misusing Drugs and Misapplying Paternalism; Injecting Portuguese Decriminalisation into the UK Justice System', UK Legal Issues Journal, Volume 4, Issue 1, January 2016
Co-author, 'The HIV Stigma; Duty or Defence?' UCL Journal of Law and Jurisprudence, Volume 4, Issue 1, March 2015
EDUCATION & AWARDS
LLM Distinction, Teesside University
LLB (Hons) First Class, Teesside University
CBA Bursary for Excellence in Advocacy
The Rachel Lawrence Prize
Inner Temple Exhibitioner
The Ian Pennock Award for Excellence in Law
Outside her practice, Ellen has undertaken a number of voluntary roles including teaching children of secondary school age the legislation regarding revenge porn and consent through SPITE and the Schools Consent Project and helping prisoners improve their communication skills with debating through the Vocalise programme.
Liam Gorman
Lead Criminal & Regulatory Clerk
Chris Gibbin
Clerk (Middlesbrough)
Alyson Hailes
Criminal & Regulatory Clerk
R v B (2021)
Represented a defendant at Catterick Military Court in a six-handed matter concerning disgraceful conduct and misconduct through alcohol in a trial lasting six days. The Defendant was acquitted of the most serious charge against him.
R v CE (2021)
Instructed as a led junior in a six-handed murder trial lasting nine weeks. The Defendant's telephone evidence was of particular importance and a full download of the telephone was obtained and reviewed in order to produce a detailed phone schedule which was put before the Jury.
R v E (2021)
Successfully prosecuted multiple counts of outraging public decency following 'upskirting' offences in Eldon Square in a trial which lasted six days and required the presentation of complex expert evidence regarding phone capabilities.
R v M (2020)
Acquittal of Defendant who was indicted with the theft of high value construction pallets in a trial lasting five days and involving GPS data, lengthy video footage and multiple witnesses.
R v S (2019)
Represented Defendant charged with assault, theft and criminal damage said to have occurred during a road rage incident. D was acquitted of all the charges against him despite evidence from multiple witnesses, photographic evidence and acceptance of presence.
R v HS (2019)
Represented a 12-year-old charged with robbery and possession of a bladed article in a four-handed trial in the Youth Court lasting five days. This case required particular care as all the defendants had special educational needs and all the witnesses the Crown sought to rely upon were under the age of 13.
R v C (2018)
Represented Defendant convicted of his second offence of possessing an offensive weapon (machete) at sentence and successfully excluded a drill rap video as evidence of gang involvement.
R v H (2018)
Successfully argued for the removal of a bladed article condition from a Criminal Behaviour Order against a youth who was convicted of possession with intent to supply Class A drugs.
Liam@trinitychambers.co.uk
Liam joined Chambers in August 2010 as an Office Junior after leaving school at 17. He has held a number of positions in Chambers before becoming a Criminal Clerk in 2014. In 2017 Liam became our Lead Criminal and Regulatory Clerk. In this role, Liam is responsible for the Practice Management and Development of all members within his Team. This includes fee negotiation, diary management and business development across the group.
'The clerks, in particular the lead criminal clerk Liam Gorman, are excellent. Incredibly helpful and friendly and always respond quickly to queries. Have never had a problem with the service they provide, and they make everything very easy.'
'The criminal team is run to perfection by Liam Gorman.'
'Liam Gorman is a fantastic friendly clerk always willing to help.'
'The lead criminal clerk Liam Gorman is particularly good.'
'We receive exemplary service.'
chrisg@trinitychambers.co.uk
Chris had over 9 years experience as a Senior Clerk in a barristers chambers in Middlesbrough before joining Trinity Chambers. Prior to that Chris worked in the Lord Chancellors Department, now HM Courts and Tribunals Service, at Teesside Combined Court Centre for over 10 years. During that time Chris covered most areas but the majority of his experience was gained in dealing with Criminal and Family Law matters. Chris' latter years in the LCD were spent in the Listing Office at Teesside Crown Court where he developed his skills which ultimately saw him transferring to his role in a barristers chambers.
Chris is a member of the Institute of Barristers Clerks.
Outside of work Chris enjoys playing cricket for Marske Cricket Club in the North Yorkshire and South Durham League, watching football and rugby and socialising.
'Chris Gibbin is an extremely helpful and experienced clerk.'
'The Teesside branch is spearheaded by Chris Gibbin who is extremely helpful and efficient.'
'I cannot fault the clerking services – Chris Gibbin in Middlesbrough is very helpful, offers prompt responses and is always willing to assist.'
Alyson@trinitychambers.co.uk
Alyson has a wealth of experience having Clerked at a neighbouring set for 29 years. Day to day Alyson is responsible for the Management and development of our Criminal Teams diaries. Over many years of Clerking the in North East Alyson has very strong relationships with local Solicitors who know they can rely upon her for a very high level of service.
Away from work Alyson enjoys family holidays and has had a season ticket for Newcastle united since being a child.


text:
Microsoft Expands Anti-Linux Campaign
By Joris Evers
SAN FRANCISCO -- Microsoft is expanding its "Get the Facts" campaign against Linux by talking about the reliability of Windows versus Linux systems, a company executive said this week at the Open Source Business Conference here.
Get the Facts is a marketing effort by Microsoft that compares Windows favorably with Linux and other open source software products. Microsoft launched the campaign in mid-2003 and has gradually expanded its scope to now include: total cost of ownership, security, indemnification, and, the latest addition, reliability.
"Reliability has been challenging for us. It is an area that has been very noisy," says Martin Taylor, general manager of platform strategy at Microsoft. "Customers say that reliability is very important to them and that they are hearing that Linux and Unix are more reliable than Windows."
Put to the Test
In the absence of a clear definition of reliability or benchmarks, Microsoft commissioned a study that pitted Windows Server 2003 against Red Hat Enterprise Linux 3.0 AS. As part of the study, 18 Linux and 18 Windows system administrators were hired to run the simulated IT environments of a midsized company over a four day period.
"This is about end user uptime and how easy it is to configure and maintain a reliable environment," Taylor says.
The administrators had to troubleshoot intentionally introduced errors and conduct tasks such as configuring new devices, making backups and setting up remote access. Linux and Windows ran on three Hewlett-Packard ProLiant DL380 G3 servers. One was used as an infrastructure server, one as an e-mail server and one as a file and print server.
"We found that the Linux environment provided about 15 percent more end user loss of productivity," Taylor says. Over the 26 hour test period spread over four days, the Red Hat systems had services down for 4 hours, 59 minutes, and 44 seconds, while the Windows system had users waiting for services for 4 hours, 20 minutes, and 19 seconds, according to a copy of the study, which was conducted by VeriTest.
Additionally, the study found that the Windows administrators were able to complete more assigned tasks than their Linux counterparts. Also, the troubleshooting was easier on Windows, according to the study. On the Windows side the administrators needed 33 percent less in average total time to do their tasks than on the Linux side, the study says.
Linux administrators ran into a number of issues including a lack of integration, bad documentation, missing drivers, and update patches that caused trouble, Taylor says. Also, Windows warned the administrators when the system was low on memory, for example, allowing them to act, while the Linux system did not, resulting in system downtime, Taylor says.
What About Viruses?
But open source advocate Bruce Perens disputes the notion that Windows is more reliable than Linux and gives a simple example: computer viruses.
"Look at the viruses. Every day my mailbox gets 30 Windows viruses in it. They come from systems that have already been infected and are just sending out viruses to everyone they know. And that is not happening to the same extent for Linux or open source software," he says.
According to Perens, open source software will always be less prone to virus attacks because it was designed to be connected to the Internet. "Microsoft is still catching up with that," he says.
Having compared "apples to apples," Microsoft's Taylor says that he feels good about Microsoft's reliability story.
However, in real life Windows and Linux are not used for the same type of tasks, according to an independent Yankee Group survey of 509 IT users released earlier this week. The hourly cost of Windows downtime in actual user environments is three to four times higher than that of Linux downtime, according to Yankee Group.
Windows downtime is more expensive because the operating system is used for more crucial tasks in businesses when compared with Linux servers, according to the Yankee Group survey. Users also told the researchers that Windows and Linux security are nearly equal and that Windows recovers 30 percent faster from attacks than Linux servers.
Furthermore, according to Yankee Group, Linux is not displacing Windows in server rooms, but most users are installing Linux servers parallel with Windows servers.
Microsoft plans to use the reliability data it got from the VeriTest study in new ads, Taylor says.
Robert McMillan of the IDG News Service contributed to this report.


Antonio Allegra passed away suddenly on January 31, 2019 in Phoenix, Arizona, at the age of 52. Born March 15, 1966 in Rochester, New York he was the son of Carmelo and Giovanna Allegra. Tony is survived by his father Carmelo Allegra; brother John (Diane) Allegra; sister Josephine Fenton; niece and nephews Nicole, Jacob and Nicholas; and, great-nephew Jackson. Tony was predeceased by his mother Giovanna Allegra.
Relatives and friends are invited to Heritage Funeral Chapel on Monday, February 4th between 4:00 and 7:00pm for a visitation. Funeral Mass will be held Tuesday, February 5th at 10:00am at St. Thomas More Catholic Church, 6180 W. Utopia Rd. Glendale. Interment will immediately follow at Holy Cross Catholic Cemetery, 10045 W. Thomas Rd. Avondale.
To send flowers or a remembrance gift to the family of Antonio Allegra, please visit our Tribute Store.
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SAO PAULO/BRASÍLIA (Reuters) - Brazil's President Michel Temer said on Friday he had reached an agreement with Roraima state Governor Suely Campos for a federal "intervention" in the state that borders Venezuela.
Temer said via Twitter that he and the governor came to the conclusion that a negotiated intervention would be the best solution to "pacify" the situation in Roraima.
Waves of Venezuelan migrants have been entering the border area in recent months, seeking refuge from poverty and hunger in the neighboring country. The thousands of refugees are straining public services and the state's finances.
On Thursday, police officers and agents in Roraima's prisons called for a strike protesting delays in salary payments.
"The situation in Roraima is becoming worse. We have tried ways to rescue the state with resources, but couldn't find a legal way to do so," President Temer told journalists after the meeting with the governor and other government officials.
"That's why I told the governor that one way to solve the problems for now, particularly the salary situation, would be the federal intervention," Temer said.
According to local TV broadcaster Globo, Governor-elect Antonio Denarium, who is from the same party of President-elect Jair Bolsonaro, the PSL, would be named by Temer to lead the intervention, which would end on Dec. 31.
Denarium, and all other governors, as well as Bolsonaro, take office on Jan. 1.


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The Obesity Society Issues New Position Statement: Covid-19 Vaccines Are Effective in People with Obesity
Vaccines such as Pfizer, Moderna, Johnson & Johnson and AstraZeneca are designed to prevent severe Coronavirus-19 Disease (COVID-19) due to acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and are highly efficacious. The efficacy is not different in people with and without obesity except for AstraZeneca which is not known, according to a new position statement from The Obesity Society (TOS), the leading scientific membership organization advancing the science-based understanding of the causes, consequences, prevention and treatment of obesity.
Trials have demonstrated high efficacy in individuals with and without obesity against COVID-19-associated hospitalization and death. Therefore, TOS encourages individuals with obesity to undergo vaccination with any of the available vaccines authorized for emergency use by the U.S. Food and Drug Administration as soon as they are able.
"Analysis of COVID-19 vaccine efficacy in certain disease sub-groups has been difficult because the number of trial participants with the disease was too small. This was not the case for obesity. Because the prevalence of obesity among trial participants was high, and because obesity is highly associated with hospital admission and death in COVID-19, the trial results were able to show that, contrary to concerns of reduced vaccine efficacy in people with obesity, that the vaccines were just as efficacious among persons with obesity compared with persons without obesity," said Alexandra M. Hajduk, PhD, MPH, an epidemiologist and associate research scientist in the Department of Internal Medicine (Geriatrics) at Yale School of Medicine in New Haven, Conn. Hajduk is one of the co-authors of the position statement.
The disease of obesity is a recognized risk factor for increased morbidity and mortality in persons with COVID-19 subsequent to infection with the SARS-CoV-2 virus. In addition, obesity is associated with conditions that are independent risk factors and predictors of mortality from COVID-19, including diabetes, cardiovascular, cerebrovascular and pulmonary diseases.
Due to the increased prevalence of severe disease, hospitalization, and death, the Centers for Disease Control and Prevention (CDC) identified obesity as body mass index (BMI) ≥30 kg/m2 as a high-risk medical condition in the COVID-19 pandemic. On Dec. 20, 2020, the CDC's Advisory Committee on Immunization Practices recommended that persons aged 16-64 years with obesity should be prioritized for vaccination in Phase 1c of the phased allocation to provide guidance for federal, state and local jurisdictions where vaccine supply was limited.
Authors of the position statement wrote the document in response to published literature, as well as inquiries made to the Society by patients, providers, Society members, policymakers and others regarding the efficacy of vaccines in persons with obesity against SARS-CoV-2.
"In addition to general misconceptions about the disease of obesity, speculation on the effectiveness of COVID-19 vaccines in obesity has certainly added to vaccine hesitancy in those individuals with obesity. I hope this position statement not only will encourage those with and without obesity to get vaccinated, but to continue the conversations on the existing weight bias in our current health policies and poor coverage and reimbursement of effective treatments for obesity," said first author, W. Scott Butsch, MD, MSc, director of obesity medicine at the Bariatric and Metabolic Institute at the Cleveland Clinic in Ohio.
In their review, the authors found the following based on each of the vaccines:
Pfizer: In a sub-group analysis of the 13,218 participants with obesity (BMI ≥30 kg/m2, 31.5% of the study cohort), vaccine efficacy was 95.4 % among participants with obesity compared to 94.8% among participants without obesity. Further stratification by age revealed vaccine efficacy of younger adults (age 16-64) with obesity (94.9 %) and older adults (age ≥65) with obesity (100%).
Moderna: In a sub-group analysis among participants with severe obesity (BMI ≥40 kg/m2; 6.5% of cohort) demonstrated a vaccine efficacy of 91.2%, with only one case of severe COVID-19 illness identified among 901 participants with severe obesity, compared to 11 cases among 884 participants in the placebo group with severe obesity. Post hoc analysis reported a vaccine efficacy of 95.8% for participants with obesity (BMI ≥30 kg/m2; 34.5 percent of cohort), with 2 COVID-19 cases in the vaccine group and 46 in the placebo group.
Johnson & Johnson: There were 12,492 participants (28.5% of cohort) with obesity (BMI ≥30 kg/m2) in the trial. Vaccine efficacy 14 days after dose one was 66.8% and 65.9%, 28 days after dose one compared to placebo in participants with BMI ≥30 kg/m2. There were no deaths attributable to COVID-19 in the vaccine group, whereas 6 of the 7 fatalities due to COVID-19 in the placebo group were among participants with obesity.
AstraZeneca: Participants with obesity (BMI ≥30 kg/m2) comprised 19.4% and 20.3% of each trial cohort and was the most common comorbid condition. In an interim sub-group analysis of participants with one or more comorbidities, the vaccine efficacy was 73.4%, though, in the updated sub-group analysis, the vaccine efficacy was 62.7%. The specific vaccine efficacy and safety data in persons with obesity is not yet published.
The following recommendations are currently endorsed by TOS regarding vaccine efficacy in persons with obesity:
1. TOS has confidence in the FDA-approved vaccine trials and the CDC's Advisory Committee on Immunization Practices updated interim vaccine allocation recommendations in the indicated U.S. populations, including those individuals with obesity and severe obesity.
2. TOS recommends that persons with obesity be vaccinated for prevention of COVID-19, in agreement with CDC recommendations, as obesity is clearly associated with an increased risk of more severe course of COVID-19 disease and death.
3. There is no definitive way to determine which COVID vaccine is "best." Current FDA-approved COVID-19 vaccines from Pfizer, Moderna, and Johnson & Johnson were all highly efficacious against COVID-19–associated hospitalization and death in trials, and were found to be equally efficacious in persons with obesity compared to normal weight individuals. TOS advises persons with obesity to accept whichever available vaccination is offered.
4. Publication of long-term vaccine efficacy outcomes, stratified by obesity status, in peer-reviewed journals is needed and is strongly encouraged.
5. Currently, available peer-reviewed data do not support the hypothesis of impaired humoral responses to SARS-CoV2 vaccine in people with obesity.
6. TOS recommends that in the development of care plans for patients with COVID-19, obesity (BMI >30kg/m2) and severe obesity (BMI ≥40kg/m2) should be included as a significant risk of more severe course and outcome of COVID-19.
7. TOS strongly supports evidence-based weight management therapies which support a healthy BMI and the promotion of COVID-19 prevention strategies, including vaccine prioritization. TOS strongly supports policies which ensure access to such treatments, including adequate and equitable coverage for behavioral, medical, device and surgical treatments for obesity.
TOS plans to monitor emerging data on vaccine efficacy and will issue an updated evidence-based position statement at a future time.
"As new, more transmissible variants of SARS-CoV2 emerge, including the Delta variant, vaccination efforts are even more pressing to help limit the spread of disease. These vaccines work in individuals with and without obesity. We want to end this pandemic. Let's make it happen by getting vaccinated," said Catherine Kotz, PhD, FTOS; professor, University of Minnesota (Integrative Biology and Physiology), associate director of research, Geriatric Research, Education and Clinical Care, Minneapolis VA Health Care System; and president of The Obesity Society. Kotz is a co-author of the position statement.
"Accruing data on obesity and risk of COVID-19 severity are shocking, alarming and tragic. As individuals with obesity have a greater risk of severe COVID-19, in a sense they have even more to gain by getting vaccinated, preventing heart-breaking outcomes. By getting vaccinated, we are protecting ourselves and each other; let's get vaccinated!," said Ania M. Jastreboff, MD, PhD, associate professor, Yale University School of Medicine, an endocrinologist and obesity medicine physician-scientist and vice chair of TOS's Clinical Care Committee. Jastreboff is the senior author of the position statement.
Study Reveals How Our Immune System Reacts to Covid-19 Variants
mRNA Vaccines Slash Risk of Covid-19 Infection by 91% in Fully Vaccinated People


Election officials recently outlined steps they are taking to eliminate hacking risk and ensure voter information and votes aren't compromised in the upcoming election.
State Board of Elections officials say that they will be vigilant in surveying for hackers by closely monitoring Illinois' voter databases to identify cybersecurity threats. More extensive firewall protections have been installed to protect election results and voter records, cybersecurity experts have been hired to watch for irregularities, and local election officials have received thorough cyber training. Illinois National Guard cybersecurity specialists will also be on standby to provide cybersecurity support in the event the Board of Elections needs assistance leading up to or on Election Day.
In 2016, 76,000 Illinois voters' information was exposed through a data breach. Officials said that though the hackers accessed the voter information, they did not alter votes or election results.
If you suspect that you have been the victim of identity theft, contact the Illinois Attorney General's Identity Theft Hotline at 866-999-5630.


In this article the authors illustrate the importance of finding mutually shared and agreed perceptions of value by discussing the value created by autonomous vehicles.
Sensible decision making involves identifying the available decision options, expected outcomes of those options, and the value generated by the outcomes. When the decision is made by a group instead of an individual, situation gets complicated. The decision group members may have different expectations on the outcomes, and perceive the resulting value differently. Therefore, the decision makers may find any decision alternative good, bad, or something in between.
When making decisions, the starting point in evaluating the options should be in understanding the outcome of each decision. Unfortunately, many decisions have indirect effects that make the ex-ante evaluation of outcomes complicated, or even impossible. These questions and challenges gain relevance along the new technologies that emerging platforms enable.
What is the value that derives from a decision?
As a practical example, consider the prospects of autonomous vehicles. Removing human drivers from traffic through autonomous vehicles bring upon various elements that create value. Existing research refers to these as the dimensions of value. In turn, the particular importance of these different dimensions depends on the distinctive value perception of each individual. Different dimensions of value can influence the established perceptions on driving, owning, or sustainability. Driving-related developments include improved safety (no human errors), time saving (no need to drive provides freedom for other tasks), and higher throughput for the roads (autonomous vehicles need smaller tolerances).
In turn, owning of the cars are likely to change, as different sharing-economy based models take away the need for ownership, increase the utilization of each vehicle, and enables a reduction in the need for parking places, especially in city centers. Sustainability of the traffic increases as there are less vehicles in the roads, whereas ride-sharing solutions fill the remaining cars. However, one could disagree on the value of these changes and, for example, whether ride-sharing is a positive thing, since some of us value the seclusion of private cars or argue that privacy is prerequisite to work effectively during the trip. This indicates that all these mentioned dimensions of value in autonomous vehicles are tradeoffs in terms of perceived value.
Typically, decisions are compromises between two (or more) views. This implies that the achieved decision balances between two orthogonal axes, whereas the jointly experienced value increases to the top-right corner. The compromise takes place in a continuum between the two ends (see Figure 1). When the decision is composed in favor of goals set by one view (Policy A), it usually contradicts the goals set by another (Policy B). For example, Finns are accustomed to universal public healthcare, provided at reasonable cost, but with high quality. Simultaneously, an average tax payer might wish for better availability and shorter queues for the services, but for lower costs for the system through a decreased tax rate. Since a compromise takes place somewhere in between the two views, it is impossible to fulfill both competing goals simultaneously.
Therefore, rather than appealing for their cause, the decision-makers should target solutions that simultaneously increase the perceived value for both views. These resolutions require groundbreaking thinking, but when these revolutionary ideas emerge, they make the solution more appealing to both parties and shift the jointly perceived value of the achieved compromise toward the top-right corner (as illustrated in Figure 2). Both policies see themselves as winners. These solutions excel at acknowledging the value perceptions that are jointly shared between different views.
Revisiting the idea on the value of autonomous vehicles, what would be a change that is unanimously seen as a positive? Surely, one answer would be higher efficiency, especially if it comes without increased operating costs. Therefore, if policy makers would want to expedite the rise of autonomous vehicles, suitable arguments for their cause would be the changes that enable optimal driving in terms of energy consumption. So, how would autonomous vehicles contribute to improving fuel-efficiency?
We believe that there are a number of factors improving the economy of driving, some of which are neglected in current discussion. First, removal of human drivers enables optimizing the driving behavior and habits. Rather than educating people to drive economically, we can simply program the driving software to follow the current best practices.
Second, since the drivers become software with an internet connection, all cars can interact with each other. By knowing the destination and route plans of each vehicle, the system can even out and optimize the throughput of our roads, avoiding unnecessary congestion.
Third, the interconnection allows for the cars to cooperate with each other. This cooperation makes the traffic lights obsolete, as the intersection lights can be replaced with a simple beacon. Instead of allotting time periods for drivers coming from each direction, the beacon can designate individual turns for each and every vehicle to cross the intersection.
Fourth, and perhaps most notably, no longer will the cars stop in traffic lights. Derived from the previous changes, since the vehicles are now aware of the routes of their fellow road users and are issued individual turns for each intersection, the cars will moderate their speed between junctions and arrive into each at the optimal moment. The travelling experience becomes smoother, the need for constant braking and acceleration in urban areas is eliminated, the fuel economy is improved, and the emissions are reduced, which leads to improved air quality. We posit that these factors should be in a more focal role in the current discussion.
The importance of these benefits derives from their relevance to the key dimensions of value and the shared value perceptions. The cornerstone in urban traffic planning is to minimize the average time spent waiting in traffic lights. Smooth, effortless driving is achieved when there is no wait in the intersections. Therefore, it would make sense to highlight these arguments of eliminated waiting time and improved sustainability in the public domain. These are the key benefits to society that derive from autonomous vehicles.
Decisions are important, but equally relevant is how their outcomes are perceived. Depending on the perception, the same decision may appear to be good, bad, or somewhere in between. Sometimes, the decision-makers can lose the big picture and focus on a small detail, leading to sub-optimized decisions. By carefully considering the dimensions of value and the different value perceptions, platform actors can find solutions that all parties can agree.
 Underlining the relevance of the idea, there already exist solutions for this goal (such as Waze), that are currently targeted to human drivers. With autonomous vehicles, we can maximize the benefits of these systems.