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Pancreatic Cancer: Translation of New Ideas
The New York Academy of Sciences
Presented by the Cancer and Signaling Discussion Group
Recent years have witnessed remarkable developments in our understanding of pancreatic ductal adenocarcinoma, and many new concepts are beginning to be translated into novel therapeutic approaches. Though pancreatic cancer remains one of the deadliest cancers, work on the fundamental biological programs that drive the disease has yielded insights into the importance of stromal cells within the tumor, the behavior the neoplastic epithelial cells, and the paracrine signals that tie them together. This symposium will cover the latest research developments in pancreatic cancer, with a focus on preclinical and early clinical investigations of rationally targeted drugs that were translated from basic science observations.
This event will also be broadcast as a webinar.
Please note: Transmission of presentations via the webinar is subject to individual consent by the speakers. Therefore, we cannot guarantee that every speaker's presentation will be broadcast in full via the webinar. To access all speakers' presentations in full, we invite you to attend the live event in New York City where possible.
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* Presentation times and titles are subject to change.
Jennifer Henry, PhD, The New York Academy of Sciences
Kenneth P. Olive, PhD, Columbia University Medical Center
Oncogenic K-Ras and the Pathobiology of Pancreatic Cancer
Dafna Bar-Sagi, PhD, NYU Langone Medical Center
Autophagy, Metabolism, and Pancreatic Cancer
Alec Kimmelman, MD, PhD, Dana Farber Cancer Institute
Targeting KRAS in Pancreatic Cancer: Challenges and Opportunities
Adrienne D. Cox, PhD, University of North Carolina at Chapel Hill
Developing Therapies for Pancreatic Cancer
David Tuveson, MD, PhD, Cold Spring Harbor Laboratory
Addition of Algenpantucel-L Immunotherapy to Standard Adjuvant Therapy for Pancreatic Cancer: A Phase 2 Trial
Jeffrey M. Hardacre, MD, University Hospitals Case Medical Center
Meeting Close
Kenneth P. Olive, PhD
Dr. Kenneth P. Olive began his doctoral studies in 1998 with Tyler Jacks at the MIT Center for Cancer Research, investigating the neomorphic effects of mutant p53 in a mouse model of Li-Fraumeni Syndrome. While at MIT, he also helped develop a conditional mutant model of advanced lung adenocarcinoma. After graduating in 2005, Dr. Olive began a postdoctoral fellowship in the laboratory of David Tuveson at the University of Pennsylvania, later moving with the lab to the University of Cambridge in England. There he built a translational research facility for studying novel anticancer therapeutics in genetically engineered mouse models of pancreatic cancer. His studies into chemoresistance and the effects of Hh pathway inhibitors on drug delivery in pancreatic cancer were published in Science in 2009, and have led to multiple clinical trials to evaluate the approach in patients with metastatic pancreatic cancer. In 2010, Dr. Olive joined the faculty of the Columbia University Herbert Irving Comprehensive Cancer Center, where he has established a laboratory dedicated to translational science and experimental therapeutics in pancreatic ductal adenocarcinoma.
George Zavoico, PhD
George B. Zavoico, PhD, is Managing Director, Research, and a Senior Equity Research Analyst at MLV & Co, a boutique investment bank and institutional broker-dealer based in New York. He has over 7 years of experience as a life sciences analyst writing research on publicly traded equities. Prior to MLV, he was an equity analyst with Westport Capital Markets and Cantor Fitzgerald. Prior to working as an analyst, Dr Zavoico established his own consulting company serving the biotech and pharmaceutical industries by providing competitive intelligence and marketing research, due diligence services, and guidance in regulatory affairs. He also wrote extensively on healthcare and the biotech and pharmaceutical industries for periodicals targeting the general public and industry executives. Dr Zavoico began his career as a Senior Research Scientist at Bristol-Myers Squibb Co., moving on to management positions at Alexion Pharmaceuticals, Inc. and T Cell Sciences, Inc. (now Celldex Therapeutics, Inc.). He has a BS in Biology from St. Lawrence University and PhD in Physiology from the University of Virginia and has held post-doctoral positions at the University of Connecticut Health Sciences Center and Brigham and Women's Hospital and Harvard Medical School.
Jennifer Henry, PhD
Dafna Bar-Sagi, PhD
NYU Langone Medical Center
Dafna Bar-Sagi, PhD, has been the senior vice president and vice dean for science, chief scientific officer of NYU Langone Medical Center since the summer of 2011. She is also a Professor of Biochemistry. One of the country's leading cancer biologists, Dr. Bar-Sagi is widely known for elucidating cellular pathways involved in controlling cell growth. She has published more than 100 peer-reviewed research papers in leading journals on the molecular mechanisms underlying tumor development, devoting considerable research to RAS proteins, essential control elements of molecular machineries that drive the neoplastic process in many human cancers. Prior to joining the Medical Center in 2006 as chair of the Department of Biochemistry, Dr. Bar-Sagi headed the Department of Molecular Genetics and Microbiology at the State University of New York (SUNY) at Stony Brook. She earned her undergraduate and master's degrees from Bar-Ilan University, Israel, and her PhD from SUNY at Stony Brook. She has been a member of many scientific advisory boards including Starr Cancer Consortium, Pancreatic Cancer Action Network, and Abramson Family Cancer Research Institute and has served on the editorial boards of multiple journals including Cancer Cell, Oncogene, and Molecular and Cellular Biology.
Adrienne D. Cox, PhD
Adrienne D. Cox, PhD, is Associate Professor of Pharmacology and Radiation Oncology at the University of North Carolina at Chapel Hill. She was a National Merit Scholar at Pomona College, a founding student of the interdisciplinary Biomedical Sciences PhD program and a National Science Foundation Fellow at Eastern Virginia Medical School. She performed her postdoctoral studies with Channing Der in La Jolla, CA, at what is now the Sanford-Burnham Institute. Dr. Cox has extensive experience in basic and translational studies of Ras family small GTPases. Since the earliest studies of the mechanisms of action of farnesyltransferase inhibitors, she has helped to elucidate the role and importance of posttranslational modifications such as isoprenoid lipids and phosphorylation to the membrane targeting events that drive Ras family signaling specificity, and emphasized the importance of isoform differences in promoting context-dependent oncogenesis. Her focus on molecular therapeutics of pancreatic cancer is driven by these findings. A member of the Lineberger Comprehensive Cancer Center, Dr. Cox is currently Chief of the Division of Cancer Research in the Department of Radiation Oncology.
Jeffrey M. Hardacre, MD
University Hospitals Case Medical Center
Dr. Hardacre graduated from the University of Wisconsin-Madison with a BS in Molecular Biology. He received his MD from Duke University School of Medicine where he was a Howard Hughes Medical Student Research Training Fellow. He completed his surgical training at The Johns Hopkins Hospital. In 2004 he joined the Department of Surgery at University Hospitals Case Medical Center and Case Western Reserve University School of Medicine in Cleveland, OH. Currently, he is an Associate Professor of Surgery and the Section Head of Pancreatic Surgery at University Hospitals Seidman Cancer Center.
Alec C. Kimmelman, MD, PhD
Dana Farber Cancer Institute
Dr. Kimmelman is currently an Assistant Professor of Radiation Oncology at the Dana-Farber Cancer Institute at Harvard Medical School. He completed his undergraduate education at Cornell University and received his MD/PhD from the Mount Sinai School of Medicine in NY. After graduating, he completed residency training at the Harvard Radiation Oncology Program and performed his post-doctoral studies in the laboratory of Ronald A. DePinho at the Dana-Farber Cancer Institute where he identified novel genes that are important in the invasive and metastatic phenotype of pancreatic cancer. Dr. Kimmelman's lab is focused on pancreatic cancer and their recent work involves the study of the deregulation of metabolic pathways in the disease and its relation to therapeutic resistance. These studies have identified that pancreatic cancers are addicted to autophagy for continued growth and have motivated the development of two clinical trials at the Dana-Farber Harvard Cancer Center for the treatment of pancreatic cancer patients. Dr. Kimmelman is also currently an attending Radiation Oncologist at the Dana-Farber Cancer Institute and Brigham and Womens Hospital specializing in Gastrointestinal Malignancies and is the Director of Preclinical Therapeutics of the small animal microirradiator facility.
David A. Tuveson MD, PhD
David Tuveson is Professor and deputy director of the cancer centre at Cold Spring Harbor Laboratory. Dr. Tuveson obtained a bachelors degree in chemistry at MIT, followed by MD and PhD degrees at Johns Hopkins. Dr. Tuveson was a medical resident at Brigham and Women's Hospital and a medical oncology fellow at Dana-Farber/Partners Cancer Care. During his post-doctoral years in Boston, Dr. Tuveson co-developed KIT inhibitors for gastrointestinal stromal tumors with George Demetri. Simultaneously, he generated several widely-used mouse cancer models with Tyler Jacks. As an independent investigator, his lab generated the first mouse models of ductal pancreatic cancer at the University of Pennsylvania. Subsequently, Dr. Tuveson was recruited to the University of Cambridge to develop preclinical and clinical therapeutic strategies for pancreatic cancer. In Cambridge, his lab identified a variety of parameters that limit therapeutic efficacy in pancreatic cancer, including poor drug delivery and survival factors in the microenvironment. These findings are currently undergoing clinical evaluation. Dr. Tuveson was recruited back to the USA to direct the Cancer Therapeutics Initiative at CSHL and to serve as Director of Research for the Lustgarten Foundation. He continues to practice medical oncology with an adjunct appointment at MSKCC. His awards include the Rita Allen Scholarship.
Academy Friends
The Lustgarten Foundation
Transnetyx
Icarus Consultants Inc.
The high prevalence of activated forms of K-Ras in pancreatic cancer is believed to reflect the capacity of Ras-dependent signaling pathways to regulate cellular processes that are relevant to both tumor initiation and progression. A major goal of our work is to enhance the understanding of the specific roles that oncogenic K-Ras-triggered signals play in the process of pancreatic tumorigenesis, and to explore the amenability of these signals to pharmacological intervention. The talk will focus on ongoing efforts to delineate the functional contribution of oncogenic K-Ras to tumor immunity and bioenergetics.
KRAS has been shown repeatedly to be a key driver of pancreatic cancer initiation and maintenance, and is therefore a critical therapeutic target for this disease. However, despite massive efforts to develop molecularly targeted agents that directly inhibit Ras itself, no clinically successful candidate drugs have been identified. Agents that interfere with Ras membrane targeting and downstream effector function are the subjects of intense investigation as potentially more tractable approaches, yet these too remain extremely challenging. Our recent development of inducible kinase tools and identification of ERK isoform-selective functions in pancreatic cancer provide new opportunities to improve therapeutic outcomes by blocking critical signaling events driven by KRAS, and these will be discussed.
Background: Despite continued investigation, limited progress has been made in the adjuvant treatment of resected pancreatic cancer. Novel or targeted therapies are needed.
Methods: Multi-institutional, open-label, dose-finding, phase 2 trial evaluating the use of algenpantucel-L (NewLink Genetics Corporation, Ames, IA) immunotherapy in addition to chemotherapy and chemoradiotherapy in the adjuvant setting for resected pancreatic cancer (ClinicalTrials.gov identifier: NCT00569387). The primary outcome was 12-month disease-free survival. Secondary outcomes included overall survival and toxicity.
Results: Seventy patients were treated with gemcitabine and 5-fluorouracil based chemoradiotherapy as well as algenpantucel-L (mean 12 doses, range 1-14). After a median follow-up of 21 months, the 12-month disease-free survival was 62%, and the 12-month overall survival was 86%. The most common adverse events were injection site pain and induration.
Conclusions: The addition of algenpantucel-L to standard adjuvant therapy for resected pancreatic cancer may improve survival. A multi-institutional, phase 3 study is ongoing (ClinicalTrials.gov identifier: NCT01072981).
Alec C. Kimmelman, MD, PhD, Dana Farber Cancer Institute
Pancreatic cancers have an intense resistance to currently available therapeutics which results in a dismal 5-year survival rate. This resistance points toward altered cell survival and metabolic pathways. In this regard we have previously shown that pancreatic cancers have elevated basal autophagy which is required for their continued growth. Importantly, inhibition of autophagy pharmacologically or by RNAi approaches leads to decreased oxidative phosphorylation, a drop in ATP production, and ultimately growth inhibition. These findings have implicated autophagy as a key component of pancreatic cancer metabolism and have motivated the opening of multiple clinical trials assessing the efficacy of hydroxychloroquine as an autophagy inhibitor in pancreatic cancer. Additional work from our group has demonstrated that oncogenic Kra spromotes a systematic rewiring of pancreatic cancer metabolism allowing glucose and glutamine to be utilized in a variety of biosynthetic pathways. Importantly, several of these metabolic pathways are critical for tumor growth and therefore represent potential therapeutic targets. These and other aspects of pancreatic cancer metabolism will be discussed.
Developing Therapies in Pancreatic Cancer
David Tuveson, MD, PhD Cold Spring Harbor Laboratory
Pancreatic Cancer is a deadly disease that lacks effective therapies. We have generated a mouse model of advanced pancreatic cancer and used it to investigate the response to conventional and investigational agents. Recently, we showed that that drug delivery is hampered by poor perfusion and diffusion of agents into pancreatic tumors, and devised a variety of strategies to circumvent this. Currently, we are characterizing a biological agent that attenuates the activity of Connective Tissue Growth Factor (CTGF). We find that CTGF antagonism promotes apoptosis of neoplastic cells and survival of mice when co-administered with the cytotoxic gemcitabine, without increasing the delivery of gemcitabine. The potential mechanisms of action of this approach and relevance to the clinic will be discussed.
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American Bar Association 2018 Midyear House of Delegates Meeting
Retired Chief Justice Maureen O'Connor
Chief Justice Maureen O'Connor
Thank you, Deborah, for that warm introduction. I would also like to thank President Hilarie Bass, President-elect Robert Carlson, and all members of the House of Delegates.
As the president of the Conference of Chief Justices, it is my honor to continue the tradition of addressing the ABA House of Delegates.
This tradition — in its ninth year — reinforces the strong alliance between the ABA and our state courts. As we all know, attorneys play a key role in supporting fair and impartial courts. You educate citizens about how the system works. And you help protect access for all. The Conference of Chief Justices appreciates the work you do to strengthen our justice system.
Allow me to start by sharing some news, and because I consider myself someone who sees the glass half full, I'll start with the good news. The National Center for State Courts recently released its annual survey on the "State of the State Courts," and it shows that the courts remain the most trusted branch of state government.
A whopping 71 percent of the respondents have confidence in their courts, compared with 61 percent in their governors and 57 percent in their state lawmakers. As we continue to try to better serve the public, I think you'll agree this is great news
But we have work to do. The survey also reports that six out of 10 people believe state court judges are out of touch with community concerns. And 73 percent said delivering access to justice in rural courts is a problem. The survey also shows that 78 percent view the opioid epidemic as a major problem in their communities, one that's not improving.
These drugs are killing our family members and our friends — in big cities like Chicago and in small ones like Chillicothe, Ohio. In the East, in the West and everywhere in between. Because they are so available and because they are so lethal — these drugs are being abused nationwide and are literally tearing apart our social fabric.
If you don't believe me, visit a courthouse in West Virginia or New Mexico or Massachusetts, or just about any other state in the country. And just watch. Watch as judges make decisions about whether opioid abusers should go to jail or to a treatment center. About which treatment they should receive. And about where their children should live. This epidemic has flooded the courts with abusers and their relatives, all of whom desperately need our help. Judges and court administrators recognize their role in managing this epidemic.
We need to be a part of the solution. The Conference of Chief Justices and the Conference of State Court Administrators have formed a national opioid task force. The task force's goals are ambitious. This new Task Force met just last week to identify these goals.
The identification of court programs that have met with success is crucial. The state courts realize that it is only by partnering in our communities with treatment providers, state and local agencies and the private sector that we will effectively deal with the opioid epidemic.
The emphasis that this is a health crisis more so than a criminal matter is a paradigm shift that has taken root in the legal and medical communities and in many instances in the policy makers of federal, state and local governments.
Indiana's Chief Justice, Loretta Rush co-chairs the Task Force. Stay tuned as policies and practices and education and trainings are identified for the judiciary and court staff that move us in the direction of effectively addressing this epidemic.
The task force will have membership consisting of judges and others who are on the front lines of this epidemic working in family courts and other trial courts. I want to switch gears and talk about money, specifically court fines, fees and bail — and the desire by many state court judges to reform this system.
If you live in Ohio, as I do, you may have heard of Markcus Brown, who has become a poster child for bail reform. He lives in Dayton. He and some friends were at a bus stop last year, when police officers approached them for violating the transit authority's dress code: They were wearing hoodies and saggy pants.
The ban on hoodies and saggy pants is part of a larger set of rules that officials there say has helped decrease criminal activity on transit authority property. Brown, who was warned twice before about trespassing on transit authority property, refused to cooperate with the officers, so they took him to jail. His bail was set at $150. A lot of people can come up with $150 very quickly. Maybe everyone in this room can.
But Markcus Brown couldn't. He spent nine days in jail until his mother could secure a car title loan so he could make bail. While he was in jail, he missed a job interview. After he got out, he learned he was banned from public buses in Dayton, so he now needed a car before he could find a job. But if you can't come up with $150 for bail, what kind of car can you afford? Probably not one that runs.
And there's the irony right there: Drug dealers, burglars and other criminals who threaten public safety often have no trouble coming up with their bail and are back on the streets in no time. Non-violent offenders sometimes spend days or weeks in jail before their cases get to court.
It has been my honor and privilege to co-chair the National Task Force on Fines, Fees and Bail Practices, and I have what some would call a very strong opinion on this issue: No one in America should be sent to jail solely because they are poor.
In too many instances, state and local officials treat the court system as an ATM for their spending priorities. This must change, and our task force is committed to taking steps to drive that change.
The task force has developed a bench card for judges to help determine a person's ability to pay as well as other solutions, which can be found on the National Center for State Court's >website. Even people who don't particularly care about the Markcus Browns of the world often care that Dayton and most other cities are paying as much as $200 a day, with no hope of recouping that amount in costs, to incarcerate these non-violent offenders in a local jail. I think you'd agree this is not a good use of taxpayers' money, and we need to do better.
If you're as passionate about this issue as I am, please join me to help make a difference in this area. In closing, I would like to recognize one of the most important roles of the ABA and that is the long standing commitment of the ABA to assist with the selection of our judiciary. Whether it's weighing in on the way states elect, select or appoint judges or taking an active role in the appointment process of our federal judiciary.
Please continue to ensure that the treasured practice of an apolitical, nonpartisan evaluation continues. That legal competency, experience, and judicial temperament are the paramount factors that must guide the process.
We, all people in America, whether citizens, residents, or visitors, need and deserve a judiciary that is independent, vital, and above reproach. On behalf of the Conference of Chief Justices, thank you, President Bass and the House of Delegates for allowing me to address you.
It's my hope that I've made it clear that state courts are vitally committed to accountability, impartiality and fairness. I also hope that in 2018, we — the Conference of Chief Justices and the ABA — will double down on our common cause to support equal and accessible justice for all.
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redpajama_set_name: RedPajamaCommonCrawl


text:
package VMOMI::CustomizationLinuxIdentityFailed;
use parent 'VMOMI::CustomizationFailed';

use strict;
use warnings;

our @class_ancestors = (
    'CustomizationFailed',
    'CustomizationEvent',
    'VmEvent',
    'Event',
    'DynamicData',
);

our @class_members = ( );

sub get_class_ancestors {
    return @class_ancestors;
}

sub get_class_members {
    my $class = shift;
    my @super_members = $class->SUPER::get_class_members();
    return (@super_members, @class_members);
}

1;

redpajama_set_name: RedPajamaGithub


This is an Idea I had a couple of days a go, no Idea if it can be done.
What about a stand-alone launcher for glitch, with singleplayer and perhaps even LAN network games.
Nothing would change apart from loss of home streets, avatars and similar details. It would be like your own mini-glitch you could play at home, and even set up a "server" for your friends.
I don't really think I would enjoy a singleplayer glitch, The community is so great!
But I'd rather have glitch than no glitch at all.
Yes keeda, I see the point you are making but as creative commons liscense depicts no commercial gain can be made not many are going to be willing to do an online version, I think this is just about the best chance glitch has right now.
Deus: Awesome! Do you need any help with it? I have extended knowledge of the Python programming language and I'm sure I could pick up flash with the right tutorials. If not, is there any way you could give me updates I.e through email or something? I would love to hear more about it. Also, take what I said about LAN servers into account, they can be hosted loccaly without any cost needed, which would be cool as glitch still be multiplayer, if not as massive as it was before.
Please respond to me, either on this thread of via my email at hector8mail@gmail.com. Hope you see this.
Maybe IOS version? just me? stoot?
"New Glitch" could be for IOS or Android. They could have a Kickstarter (think about all and all of those glitch players who miss it, a simple donat button wouldn't do much though), and have personal servers for the worlds. Events could be made and scheduled by owners. Servers could make areas using streeet projects, and delete ones that were not to the owners liking. Home streets would drift and dock to servers for visiting. Most channels would be server sourced, like trade or rook alerts, but if Tiny speck wanted to operate a few channels that would be fine.
If the singleplayer glitch would be an app, I think It should be for android.
Can someone inside TS Give us some help on this? I really want to know how far a singleplayer glitch could go.
Very nice idea Durza. I am going to program a Singleplayer glitch on Html 5, then perhaps move on to a multiplayer one, but that would depend on popularity. I will take what you have said into account, but I'm not sure IOS or android are the way forward. In my opinion, Glitch is too complicated a game to be forced into the limited controls on a phone/tablet. A new glitch should either be online, or a client based game.
Yeah... But there is code given for IOS. Take a look at the developer website.


text:
Cannula is a genus of African grasshoppers in the family Acrididae. There are at least three described species in Cannula.

Species
These three species belong to the genus Cannula:
 Cannula gracilis (Burmeister, H., 1838) c g
 Cannula karschi (Kirby, W.F., 1910) c g
 Cannula vestigialis Roy, R., 2003 c g
Data sources: i = ITIS, c = Catalogue of Life, g = GBIF, b = Bugguide.net

References

External links

Acrididae

redpajama_set_name: RedPajamaWikipedia


text:
The Jewish Collective
Breaking News / Middle East
Lebanon will never agree to grant citizenship to so-called Palestinian refugees: Foreign Minister
by BtNews · September 14, 2018
In light of reports that the US will disclose a citizenship plan for so-called Palestinian refugees in Arab countries, Lebanon's Foreign Minister Jebran Bassil emphasized that Lebanon "will never accept the naturalization of Palestinian refugees," Lebanese media reported on Thursday.
"This position is neither new nor surprising. We are accustomed to such positions taken by the United States and Israel, and I have always been aware of this the latest was in front of the Arab League two days ago," Bassil said.
Noting also the latest US decision to cut funding for the UNRWA, he said: "The disability of Arabs encourages the transition from the cessation of funding for UNRWA to the next step. But if the entire world accepts naturalization, Lebanon will never accept it."
"As we defeated Israel by removing its occupation, we will defeat it with the naturalization project and with the right of return, which will remain sacred," Bassil fantasized.
Israel building a massive anti-terror wall to protect civilians from Hezbollah
Lebanon is currently home to roughly 590,000 'Palestinian refugees' (out of some five million worldwide), according to official Lebanese figures.
Earlier this week the US announced the closure of the PLO terror group mission in Washington.
"The United States was paying [the Palestinians] tremendous amounts of money. And I'd say, you'll get money, but we're not paying you until we make a deal. If we don't make a deal, we're not paying. And that's going to have a little impact," President Trump said last week.
The Trump administration has cut funds to the United Nation's Palestinian refugee agency UNRWA—an organization that cares for great-grandchildren of refugees—and pulled out of the world body's human rights council due to anti-Israel bias.
The US government has also ended some $200 million in payments by USAID to the Palestinian Authority and Gaza.
- 7 hours ago
PM Netanyahu compares EU's reaction to Iran deal breaches to 30's Nazi appeasers https://t.co/HnYAyruBUP https://t.co/TGXGbef3R6
Italy: Air-to-air missile, arsenal seized during raids on neo-Nazi cell https://t.co/AtKrmyM0Iv https://t.co/4oqlnrupGm
Watch – Hamas summer camps: Raising the next generation of Muslim terrorists https://t.co/VcFnZvHzpY https://t.co/8iyHYEWK91
9 wanted terrorists arrested in Judea and Samaria – Terro cell nabbed – Weapons seized https://t.co/on9o6wRsGY
US grants visa to Iran's Zarif for UN meeting, limits him and delegation to 6 blocks https://t.co/NFwUY4v5vP https://t.co/Sr96nX2OCi
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We all have those days. You wake up, go through your morning ritual, go to work, and do the typical tasks of the day. It's almost the same thing you did yesterday, and you have a constant feeling of déjà vu. It feels like you're going through the day on autopilot, and the monotony is killing you. You may feel like making some big changes in your life, but you also might have been burned by taking risks in the past. Because change is scary, you keep going through the motions even though things are just alright the way they are, but not really great. However, you don't have to live your life that way. By continuously making small changes in your daily habits, you can slowly attain the lifestyle you have always wanted without taking huge risks. We follow the same approach with our clients, but this is a mindset that transcends digital marketing.
Let's flashback to when you were first figuring out your career path. When you were in college or even high school, people would ask you what you wanted to do when you graduated. More than likely, you had an answer because it was expected that you have a plan for what you wanted to do with your life. However, once you had an internship or started studying what you envisioned doing, you might have changed your mind. It was not enough to visualize yourself in a certain job or listen to what people told you about a career choice. You had to try it out for yourself in order to see if it was a good fit for you. Maybe it was exactly what you thought, or it might have been completely different than your expectations. Nonetheless, you had to test out different jobs until you found the right one.
Think about the last time you decided to eat healthier. Rather than making small changes to your regular eating habits, like slowly cutting out a few unhealthy items here and there, you may have been sold on the latest and greatest life-changing diet. You probably dreaded the days leading up to the time when you started it, and while you were eating "healthy," you probably hated your life and counted the days until you were finished. That is, if you even had the dedication to see it through the end. When you completed your diet, you probably thought you deserved a special treat and slipped into your old habits again. Drastic changes sound great in theory, and it's one of the reasons quick weight loss plans and self-proclaimed miracle drinks sound so appealing. However, a much more feasible and effective process for reaching healthy eating habits is to introduce small changes over time.
We can apply the same logic to exercising. If you never worked out and decided to run a marathon tomorrow, the results would not be pleasant. The odds of you completing the race would be slim, and even worse, it would discourage you from wanting to work out in the future. Conversely, if you set a goal to run for a few minutes this week and a few minutes longer next week, or even tested different exercises to see what you enjoyed doing, you would slowly make gains and get into better shape.
The optimizer mindset can be applied to finding and getting good at a new hobby as well. In order to find the activities you love doing, you have to try lots of different things. Some people are musically talented, other people are gifted athletes, and some people are both. If the only hobby you ever tried was playing the guitar, your true passion could be playing baseball, but you would never know that if you only took guitar lessons. The fact of the matter is that you don't know what you enjoy until you test it. Then, once you do find the hobbies you enjoy, you might want to get better at them. You'll do that by testing small changes to your technique and see what helps you improve. Everyone is unique, so you have to constantly test your approach in order to keep your craft in top shape.
There's a good chance that you already apply this mindset when managing people at work, but you may not think of it in the same way. If you are a good manager, then you are constantly looking for ways to maximize the performance and efficiency of your employees. When someone new starts, you might test different techniques for managing that person because no two employees are the same. You will test different management strategies and give them different projects to find what they're good at. Once you establish a standard management style and deliverables, employees will have expectations for the job. If you drastically changed expectations overnight without giving your employees time to adjust, they would not be very happy. You would be disappointed with their performance and may have to fire some of them. Even worse, if the change was too disruptive, you may have to rebuild the entire department.
There are countless ways that you can apply the optimizer mindset to your daily life. The primary thing to remember is that you can reduce the risk associated with lifestyle changes when you introduce change in small increments. Quick, drastic changes are idealistic, but they are very risky. Big changes are possible, but they take time.
As you may know, the digital marketing landscape has changed. We have numerous tools that enable us to apply an agile approach to digital marketing. With today's technology, we can test small changes and measure small improvements to our websites and marketing campaigns. We no longer have to undergo complete redesigns of our websites to increase conversions and risk being burned by a drastic, expensive process. If this is all unfamiliar to you and seems a bit overwhelming, that's ok. We can help make incremental improvements at your organization. Simply fill out our contact form, and we can help bring your organization into the future.


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A Bangladeshi court has acquitted Hasnat Karim who was detained over suspecting his involvement in militants attack on a cafe in Dhaka.
A Bangladeshi court has reportedly acquitted British citizen, Hasnat Karim on Wednesday (8) who was detained without charge for two years suspecting his involvement in militants attack which killed 22 people on a cafe in the capital city of Bangladesh, Dhaka in 2016, his lawyer said.
Human rights group Amnesty International tried its best for the release of Hasnat Karim, who was in the cafe along with his daughter when the attack took place.
Karim's lawyer, Sanwar Hossain Somazder confirmed that his client would be released from jail later in the day. The lawyer has also clarified that his client would not be seeking any compensation.
Militants had attacked the cafe when Karim and family were celebrating his daughter's 13th birthday party. The militants took 22 people hostages, most of them foreigners, who were killed on the same day.
Karim was detained after witnesses stated that he agreed to act as human shield during the attack.


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Madonna University
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We appreciate the global perspective you bring as an international student and we invite you to join the Geneva College community.
If you're a high school student searching for a high-quality, Christ-centered education to prepare you for your life's work, Geneva College could be right for you. Geneva offers students an academically rigorous liberal arts education in a superb learning environment.
Geneva, which was founded on and still holds true to strong Christian principles, is a place where you can make lifelong friendships with fellow students who share your values. You can develop meaningful relationships with professors who care about your academic, personal, and spiritual growth.
Preparation for your life's work
As a liberal arts college with a vocational focus, Geneva prepares students to excel in today's world. Geneva alumni serve as doctors, engineers, teachers, airline pilots, missionaries, church and community leaders, elected officials, business owners, and in many other roles requiring intellectual agility and practical wisdom.
Geneva offers over 145 undergraduate majors and programs. Our ABET-accredited Engineering program was ranked among the "Best Undergraduate Engineering Programs" in the nation by U.S. News & World Report, and 100% of our Engineering students are working or in graduate school six months after graduation. Over 80% of Geneva graduates who apply to medical school are accepted.
A Geneva education is grounded in the truth of God's Word in every aspect of student life—academics, athletics, and activities. Every one of our experienced and accomplished professors is a committed Christian who challenges students to be all that God created them to be. Our low student-faculty ratio means more personal attention and guidance in all areas of your life.
A valued private education
Geneva College is a sound investment for families who must make decisions with real budgets and long-term commitments in mind. Geneva shares a focus on value with families and strives to keep the cost of a private Christian college education within reach in several ways.
First, Geneva offers many students significant scholarships based on their high school academic performance. Second, Geneva helps high school students lower costs by reducing the credits necessary to complete a degree through programs like Early College. Third, the College community welcomes student workers who can reduce their expenses directly through their earnings.
Geneva has been named a College of Distinction six years in a row for providing students with outstanding preparation that is highly valued by employers and graduate schools and recognized as a Christian College of Distinction for high-quality academics founded on the truth of God's word.
There's a lot going on at Geneva. The College offers high-level athletic training and competition with 19 NCAA Division III varsity sports for men and women. We also offer extensive intramural and club sports that connect athletic and non-athletic students with opportunities to enhance physical fitness, character development, and leadership. Examples include flag football, indoor and sand volleyball, rugby, dodgeball, and Ping-Pong.
Organized music ensembles include The Genevans choir, Marching Band, Symphonic Band, and more. There are theater productions and Film Fest, groups such as Spanish Club and Dagohir, and professional organizations for Accounting, Engineering, Criminal Justice, and more. Geneva has 40+ student organizations and coordinates 200+ student programs and activities each year.
Geneva's beautiful 55-acre campus in Beaver Falls, Pennsylvania, is about 35 miles northwest of Pittsburgh and just miles from Ohio. The campus allows students great access, as it is within minutes of the Pennsylvania Turnpike, I-376, and I-79 and sits just 25 miles from the Pittsburgh International Airport.
Geneva is named a Christian College of Distinction, affirming the school's dedication to high-quality academics founded on the inerrant truth of God's word.
Geneva College is ranked among the Top Regional Universities in the United States | U.S. News & World Report
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As a College of Distinction, Geneva is nationally recognized for providing outstanding preparation that is highly valued by graduate schools and employers.
With its first rate programs and recognized professional accreditation in the Education field, Geneva is named a college of distinction.
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OUR CHRISTIAN PERSPECTIVE
Geneva is governed by the Reformed Presbyterian Church of North America. We believe that the Holy Bible is the foundation of all that is right, good, and true. All faculty and staff are professing Christians who care about the development of students' minds, hearts, and spirits.
Incoming students don't have to pass a litmus test of beliefs, so people of many denominations and doctrines study at Geneva. Our conversations are honest, frank, and often eye-opening.
• 63 different denominations are represented in the student body.
WHAT AN OUTCOME!
A Geneva education prepares students to think, reason, and communicate well with others. Graduates achieve quality professional performance and a life of faithful and fruitful service.
• 93% of students are employed or in grad school within 6 months of graduation.
GENEVA COLLEGE MEANS VALUE
Academic excellence and affordability are key factors in selecting a college. They make up value, and that's exactly what Geneva is noted for.
• 13:1 student-faculty ratio
ACADEMIC OPTIONS ABOUND
Geneva's most popular majors include Engineering, Business, Elementary and Special Education, Biology, and Computer Science. Other majors of note include Nursing, Communication Disorders, Music Business, Aviation Business Administration, Cybersecurity, and Student Ministry.
At Geneva, you can even work with your advisor to design and pursue an Independent Major that's just right for you.
• 145+ majors and programs
• 100+ off-campus study abroad programs
An Inside Look


text:
Q: How to get star coordinates for a given time Fixed in 10.3.1

In the documentation of StarData, there is an example that shows how to get the altitude of Sirius at a given time (in the horizontal coordinate system).
However, when I try to run the example code
StarData["Sirius",
 EntityProperty["Star",
  "Altitude", {"Date" -> DateObject[{2014, 4, 9, 22, 0, 0}]}]]

the result is

Missing["NotAvailable"]

Additionally, if I run
StarData["Sirius", EntityProperty["Star", #]] & /@ {"Altitude",
  "Azimuth"}
StarData["Sirius",
   EntityProperty["Star", #, {"Date" -> Now}]] & /@ {"Altitude",
  "Azimuth"}

I get the correct output for the first command and

{Missing["NotAvailable"], Missing["NotAvailable"]}

for the second, which is very strange. Is this a bug with the EntityProperty function?

A: This bug appears to be fixed as early as of version 10.3.1.

redpajama_set_name: RedPajamaStackExchange


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Nora Young is the host and the creator of Spark, CBC's national radio show and podcast about technology and culture. She was the founding host of the CBC Radio show Definitely not the Opera, where she often focused on new media and technology.
As a journalist, author, and speaker, Young explores how new technology shapes the way we understand ourselves and the world around us. Her book, The Virtual Self, on the explosion of data about our behaviours, opinions and actions, is published by McClelland and Stewart.
Young blogs at norayoung.ca, and produces the indie podcast The Sniffer with her friend, Cathi Bond. Her favourite technology is her bicycle. Find her on Twitter, @nora3000.
Marcus Daniels is a digital product entrepreneur, seed capital investor and innovation platform architect who helps Canadian start-ups win in global markets.
Co-founder and CEO of Highline, a VC-backed acceleration platform that helps digital start-ups supercharge growth and secure institutional capital. Focused on delivering "speed to seed" through specialized accelerator products, timely investments and programming in Vancouver, Toronto, New York and San Fransisco. Highline's foundation is derived from the Extreme Startups-GrowLab merger and financially backed by top institutional investors whose funds under management exceed $two-billion.
Daniels is the founder and executive chairman of MeshSquared Ventures, an investment and education company focused on evolving digital products. He is an investor in Highline and owner of the Toronto Standard, a conversational media and marketing company.
Prior to Highline, Marcus was the managing director of Extreme Startups, a venture capital-backed start-up accelerator. He was the chief operating officer of trendhunter.com, the world's number one trend-spotting website with over two-billion views and an innovation partner to Fortune 500 brands. He also served as the vice-president of operations and product at Frameworks. He founded the e-learning division at AME Learning, a global financial education company. A digital native, Daniels started out by hacking together ventures in 1989, which led him to co-found Fluid eNovations, an award-winning Web marketing agency.
He has significant board of director experience that includes Highline, Extreme Startups, Youth in Motion (Canada's Top 20 Under 20), Canadian eLearning Enterprise Alliance and SDEVM. Daniels is active in the community as a frequent mentor and judge. He sits on the advisory council for the Dell Center for Entrepreneurs and the board of advisors of Venture for Canada, and co-chairs the Toronto chapter of Enactus. He's a frequent speaker on growing digital start-ups, seed investing and venture capital, and corporate innovation accelerators. He has also developed digital strategy curriculum for the University of Toronto.
Marcus holds an MBA from Queen's School of Business, and a BA in psychology and economics from McGill University, and completed the Venture Capital Executive Program at Haas School of Business, UC Berkeley.
In his role as managing director of OMERS Ventures, Jim Orlando is responsible for leading investment activities in the North American market focusing on high-growth companies in the technology, media, and telecommunications sectors. With more than 14 years of experience in the venture capital and private equity sectors, Orlando has a strong track record of finding deals and closing investments, and in working with strong founders, CEOs and management teams on the ongoing development and growth of their businesses. He is responsible for OMERS Ventures' investments in BuildDirect.com, Ranovus, Shopify and Wattpad.
Prior to joining OMERS Ventures, Orlando was a managing director at OMERS Private Equity, which directly owns and actively manages a diversified, multibillion-dollar portfolio of investments in North America and Europe. Orlando was involved with direct investments in the software, mobile telephone and retail sectors.
Prior to that he held key roles with Bell Canada Capital and Battery Ventures in Silicon Valley, and he has ten years of operational experience in the telecom industry.
Orlando holds bachelor of computer engineering and management, and master of electrical engineering degrees from McMaster University.
Mark Ruddock has over 20 years of experience at the helm of venture-backed technology start-ups, including two successful exits. Ruddock is currently the managing director of international consumer lending at Wonga, one of the world's fastest-growing digital finance companies. His responsibilities include overseeing all of the consumer and e-commerce businesses outside of the U.K. These include operations in Germany, Poland, Spain, South Africa and Canada, amongst others.
Before joining Wonga, Ruddock was CEO of the Canadian wireless software company Viigo, which won numerous awards and was often regarded as the most highly used app on a Blackberry after email. Viigo was acquired by BlackBerry in 2011.
Prior to that, Ruddock was the founder and CEO of INEA, an enterprise software company that became a strategic partner to many of the world's leading financial institutions, including RBC, Scotiabank, RBS, JP Morgan Chase and Mellon amongst others. INEA had been deployed in over 44 countries by the time the company was acquired by Cartesis (now SAP) in 2005.
Ruddock has a B.Sc. from Trinity College, University of Toronto. His most dubious accomplishment is having flown over a million miles, for which he was awarded a small plastic plane that he is irrationally proud of.
Vicki is a serial entrepreneur, passionate mentor and advisor to the next generation of change-makers, and a leading advocate for entrepreneurship as a way of creating positive transformation in the world.
Saunders is the founder of SheEO. SheEO supports women who create businesses that build new models, new mindsets and new solutions for a better world. SheEO is building out a global platform to accelerate, finance and celebrate women-led ventures on their own terms.
Saunders has co-founded and run four ventures in Europe, Toronto and Silicon Valley, including Zazengo (an online platform for consumer and employee engagement for Fortune500 companies focused on sustainability), KidsNRG/The NRG Group (which went public on the Toronto Stock Exchange in 2000) and Impactanation, a global consulting firm focused on engaging youth to tackle the grand challenges we are facing.
Most recently, Saunders's passion to create a strong ecosystem for social entrepreneurs in Canada has had her advising at the Office of Social Enterprise with the Ontario government, Ryerson University, and TheNext36, with the aim to drive wealth creation and positive social change in Canada and beyond.
In 2001, Saunders was selected as a Global Leader for Tomorrow by the World Economic Forum. She has spoken regularly at events around the world, including the World Economic Forum in Davos, Women of Influence Series in Canada, Schwab Foundation for Social Entrepreneurs events and the Tallberg Forum.
David Stein is an entrepreneur, an investor and a board member who has successfully co-founded, grown and sold two technology companies.
The first company, Workbrain, is a developer of enterprise workforce management solutions. It was founded in 2000 and was acquired by Infor for $227 million in 2007. The second company, Rypple, develops sales performance management solutions. It was founded in 2008 and was acquired by salesforce.com in 2012.
By challenging the status quo and taking advantage of emerging trends, both Workbrain and Rypple grew very quickly against established competitors and delivered game-changing solutions for their customers.
He currently serves as vice-president at salesforce.com, and enjoys family time, golf, cycling and wine. In his spare time, he invests in and advises a select group of technology companies. David holds a B.Sc. in computer science from McGill University.


Functionality at the service of creativity.
Lupo has a historical tradition in photography that dates back to the origins of the company, founded in 1932 by Carlo Lupo (professional photographer) and, bearing in mind these origins, we now develop a full range of lighting products for photography and video shooting. Our passion for photography drives us to produce increasingly high quality products that can facilitate the work of professionals.
Lupo offers a full range of accessories for all models. Continuous light is undoubtedly simpler and more immediate to use in any condition, but we know the needs of photography professionals. All Lupo products are compatible with a wide range of softboxes, grids, tripods, battery kits, clamps, padded carrying cases and much more. Discover all available accessories.
We are proud to manufacture technology products with an elegant and attractive design Made in Italy. In our philosophy, aesthetics are undoubtedly at the service of functionality, but during design we give ample space to the creation of modern and pleasant lines. Great care is also dedicated to the mechanics and modularity of the internal components so that any customer assistance, whenever required by the authorized centres, is quick and easy.
Whether you are just starting your adventure in the world of photography or you are an expert, you can be sure that you will find the perfect solution for your needs with the range of Lupo lighting products. Entry-level models and ultra-professional models are available in different versions, but all without distinction are characterized by the utmost care of details and by a reliability you can count on. Always. Fashion, still-life, portrait, glamour, boudoir, food, art. The versatility of quality continuous light makes all your shots easier.
In the design and development of all our products, we pay close attention to the main features that they must have: robustness, lightness and ease of use. We want those who buy a Lupo range model to be sure that they have a reliable product that will last in time, which is easy to use and at the same time powerful and easy to carry inside and outside the studio. For this reason, all products are made with quality materials and components. The reinforced technopolymer we use for many models of our range is an incredibly durable and innovative material, widely used in all the most advanced technology sectors.
Our professional LED lighting products are all powered by the mains and by battery because we are convinced that the convenience of having versatile equipment both inside and outside the studio is critical for a professional. With a few simple accessories you can use your battery powered lights wherever you want.
In all of our products, we keep quality of light in the highest consideration and make our range increasingly more advanced in lighting technology. Our LED range features excellent colour rendering, without casts. The average values of the colour rendering index (CRI) are greater than 95. Lupo products are evolving constantly because we know that you can only strive for perfection with continuous improvement, just as everyone in professional photography and imaging in general knows. With the Lupo range models you can be sure you have reliable, high quality products that will accompany you over the years in the creation of your works.


text:
Indigenous people best custodians of threatened forests, studies show
An Embera indigenous woman with her son in Quibdo, Colombia, on March 18,2017. PHOTO: EPA
http://str.sg/47Bk
WASHINGTON (REUTERS) - Granting formal land rights to indigenous people living in the world's tropical forests is among the most effective, but underused, ways to stop illegal deforestation that fuels violence, poverty and global warming, according to new research.
Local communities are best equipped to safeguard valuable forests, and those with strong land rights are the most effective, said a raft of studies presented this week at the World Bank's annual Land and Poverty Conference.
Deforestation is known to be detrimental to the earth's climate. Clearing woodlands for agriculture and grazing, and fires that often follow, is responsible for about one-tenth of carbon emissions that contribute to a dangerous rise in global temperatures, researchers say.
Shrinking forests can cause poverty and conflicts as well, as local residents are forced to compete for fewer resources.
A six-nation study for the World Bank's Program on Forests found deforestation rates are significantly lower where communities have legal rights to the forests and government support for management and enforcement, compared with areas elsewhere.
"Critical links" exist among land security, local economic development, biodiversity conservation and reduced carbon emissions, it said.
Research from Indonesia showed conflict over land was minimised and investment was encouraged when local communities were involved in designing transportation corridors around proposed mining projects.
Another study from Indonesia showed granting long-term rights over mangrove swamps to indigenous people has better protected the critical coastal ecosystems than in areas where the endangered buffers between land and sea are not locally managed.
Less than a fifth of the world's population has formal land rights, or tenure.
More than 1,500 land rights specialists converged on the US capital this week to share their findings.
The use of giant swathes of information such as advanced satellite imagery can identify patterns such as water use in land rights and land management, said Andrew Steer, head of the Washington-based World Resources Institute and a former World Bank Special Envoy for Climate Change.
"We can show water risk, make future projections of population, use crowd sourcing and cloud computing in a way that is transforming how water is used by private companies and indigenous communities," he said.
Many papers highlighted challenges posed to developing nations by big mining and agricultural industries that are using technology to gain access to remote regions.
Nevertheless, researchers said indigenous peoples and campaigners working with them are harnessing technology as well to expose illegal deforestation or land use and seek remedies and justice.
The research is significant to help back up indigenous communities' claims that they are the best custodians of global forests.
Some critics have claimed remote tropical forests looked after by indigenous groups are protected due to a lack of development pressure rather than good management techniques.
An estimated 15 per cent of the world's forest cover remains untouched.
Brazil, once a leader in slowing deforestation, has recently been accused of rolling back gains made by providing land rights to rural people in the face of recession and a political crisis.
The World Bank estimates that forest ecosystems cover a fifth of the land in Latin America, representing half of the world's tropical forests.


text:
Garth Ancier
Find sources: "Garth Ancier" – news · newspapers · books · scholar · JSTOR (May 2009) (Learn how and when to remove this template message)
(1957-09-03) September 3, 1957 (age 63)
Perth Amboy, New Jersey, U.S.
Media executive
Garth Ancier (born September 3, 1957 in Perth Amboy, New Jersey[1]) is an American television producer media executive.
2 Career
Ancier graduated from the Lawrenceville School in 1975[2] and Princeton University in 1979.[3]
He began his broadcasting career as a high school sophomore in 1972, working as a reporter for NBC radio affiliates WBUD-AM and WBJH-FM in Trenton, New Jersey.[3] In radio, he created American Focus, a weekly national interview program carried by over 300 radio stations in the U.S., including New York's WNBC, under the non-profit Focus on Youth.[4] Ancier served as executive producer and host of over 250 episodes through 1979, each featuring a full-length career retrospective interview with guests ranging from Ayn Rand to Henry Fonda to David Brinkley. The show continued production for 17 years.[citation needed] Other guests included presidents Jimmy Carter, Gerald R. Ford, George H.W. Bush, and Caspar W. Weinberger, Lucille Ball, Howard Cosell, Henry Fonda, Tom Wolfe and Pete Rose. Five hundred of its programs were given to what is now known as the Paley Center for Media in 1984.[4]
Ancier's network television career began in 1979[5] when NBC Entertainment president Brandon Tartikoff hired him as a program associate.[6] He rose through the ranks and supervised production of the network's top comedies including The Cosby Show, Cheers, Family Ties and Golden Girls.
In 1986, Barry Diller, Jamie Kellner and Rupert Murdoch tapped the then 28-year-old Ancier to be the founding entertainment president for the new Fox Broadcasting Company,[7] where he put 21 Jump Street, Married... with Children, The Simpsons and In Living Color on the air.
Ancier went from Fox (resigning March 1, 1989) to Disney as president of network television for Walt Disney Studios on April 18, 1989.[8] He developed Home Improvement and oversaw Disney's signature franchise The Magical World of Disney, hosted by Disney CEO Michael Eisner.
From October 1991 through July 1992, Ancier served as the television consultant to the Democratic National Committee, specifically to advise on the television presentation of the Democratic Convention in New York City and reporting to DNC Chairman Ron Brown. In that role, Ancier introduced political convention format innovations, such as a 56-screen "videowall" integrated into the convention podium and program, to such forums for the first time.
Also in late 1992, Ancier co-created and executive produced Ricki Lake[7] with former Donahue producer Gail Steinberg. The tabloid talk show aired for 11 seasons from 1993 to 2004.
In 1994, Ancier re-teamed with Fox colleague Jamie Kellner and Warner Bros. CEO Barry Meyer to launch The WB as its chief programmer from 1994 to 1999,[7] where he helped put 7th Heaven, Dawson's Creek, Charmed, Buffy the Vampire Slayer, The Steve Harvey Show and The Jamie Foxx Show on the air.
Beginning in May 1999, Ancier served as president of NBC Entertainment,[7] where he helped put The West Wing and Law & Order: SVU on the air,[citation needed] while conversely being the one who cancelled the 1999 teen drama-comedy series Freaks and Geeks, a move over which in 2014 he wrote that it was "an awful decision that has haunted me forever".[9] Ancier was forced out from NBC in November 2000.[7]
Ancier returned to what had become AOL Time Warner in 2001 as EVP, Programming for Turner Broadcasting[10] (including the WB) and programmed CNN, TBS, TNT, etc., where he launched CNN's American Morning and its signature 10PM newscast with Anderson Cooper, as well as expanded Adult Swim on Cartoon Network by acquiring the then-cancelled Family Guy series from 20th Century Fox.
Ancier returned to The WB as Co-Chairman in September 2003,[citation needed] then became the Chairman of the WB Television Network from May 2004 until its merger with UPN to form The CW in September 2006,[10] during which Supernatural and One Tree Hill were launched.[citation needed] He was transferred to run In2TV, the Warners/AOL broadband television network.[10] Through the Garth Ancier Company, he was developing a talk show at the pilot stage while negotiating a potential network, cable and first-run syndicated shows deal with Telepictures and Warner Horizon as of October 2006.[11]
He served as first president of BBC Worldwide America from February 2007[10]-March 2010, where he launched Top Gear, Torchwood, and DC produced BBC World News America (BBC's first US produced daily newscast) on BBC America. Ancier also moved BBC's iconic Doctor Who series from the Syfy network to BBC America and prepared CBeebies for a US launch. Ancier was able to increase by 78% BBC Worldwide America's profit and was to continue to hold a director's seat on its board after his departure from management was planned for March 2010.[12]
In April 2013, Ancier formed Zeus Media Partners, Inc. as a retro cable network company to provide four decade focused channels (1960s-1990s), later called The Quad.[13][14]
Ancier has worked for a number of media corporations as a senior advisor to management on digital streaming, SVOD and vMVPD projects. His most notable clients have been Intel Media on a virtual-MSO system,[15] and IAC/Vimeo.[citation needed]
He is also known for being one of only two people (the other being Fred Silverman) to have programmed three of the five US broadcast television networks (founding programmer at Fox, founding programmer at The WB (now The CW), and NBC Entertainment).
^ Who's Who. 2008 ed., Vol. 1, p. 94
^ "Notable alumni > Business". The Lawrenceville School. Retrieved 16 October 2014.
^ a b Adalian, Josef (17 November 1999). "Ancier rejoins big three". Variety. Retrieved 16 October 2014.
^ a b "Student-run radio show is focusing on America". The New York Times. 11 March 1984. Retrieved 16 October 2014.
^ "Biographies: Garth Ancier". BBC Press Office. Retrieved 31 May 2009.
^ Buck, Jerry (3 September 1986). "Young Garth Ancier Has Fox By The Tail". Orlando Sentinel. Retrieved 16 October 2014.
^ a b c d e Adalian, Josef; Schneider, Michael (13 December 2000). "Peacock Zucker-punched". Variety. Retrieved 17 February 2015.
^ Haitman, Diane (30 March 1989). "Disney TV Chief Heads Back to Mainstream". Los Angeles Times. Retrieved 4 June 2014.
^ Dockterman, Eliana (15 October 2014). "Seth Rogen Confronted the Guy Who Canceled Freaks and Geeks". Time.
^ a b c d Nordyke, Kimberly (14 February 2007). "Ancier carries flag for the BBC". The Hollywood Reporter. AP. Retrieved 17 February 2015.
^ Nordyke, Kimberly (9 October 2006). "Ancier talker in the works at Telepictures". The Hollywood Reporter. AP. Retrieved 17 February 2015.
^ Andreeva, Nellie (19 November 2009). "Garth Ancier exiting BBC Worldwide America". The Hollywood Reporter.
^ Spangler, Todd (31 May 2013). "Garth Ancier Lines Up TV Vets to Launch Four Retro Cable Nets". Variety. Retrieved 13 February 2015.
^ "Quad Media Partners". garthancier.com.
^ Wallenstein, Andrew, "Garth Ancier advises Intel on virtual-MSO plan", Variety, May 8, 2012. Retrieved 2019-06-10.
"Former NBC official takes job at Turner", The New York Times, 21 March 2001.
Finke, Nikki, "Garth Ancier Stepping Down As President Of BBC America In U.S.; In Works Since July", 19 November 2009.
Presidents of NBC Entertainment
Sylvester Weaver (1953–1955)
Robert E. Kintner (1958–1966)
Julian Goodman (1966–1974)
Herb Schlosser (1974–1978)
Fred Silverman (1978–1981)
Brandon Tartikoff (1981–1991)
Warren Littlefield (1991–1998)
Scott Sassa (1998–1999)
Garth Ancier (1999–2000)
Jeff Zucker (2000–2004)
Kevin Reilly (2004–2007)
Ben Silverman (2007–2009)
Jeff Gaspin (2009–2010)
Robert Greenblatt (2011–2018)
George Cheeks and Paul Telegdy (2018–2019)
Paul Telegdy (2019–2020)
Frances Berwick (2020–present)
Presidents of Fox Entertainment
Peter Chernin (1989-1992)
Sandy Grushow (1992-1994)
John Matoian (1994-1996)
Peter Roth (1996-1998)
Doug Herzog (1998-2000)
Gail Berman (2000-2005)
Peter Liguori (2005-2007)
Kevin Reilly (2007-2012)
Peter Rice (2012-2014)
David Madden (2014-2017)
Michael Thorn (2017-present)
Retrieved from "https://en.wikipedia.org/w/index.php?title=Garth_Ancier&oldid=988792506"
BBC people
People from Perth Amboy, New Jersey
NBC executives
The WB executives
Princeton University alumni
Lawrenceville School alumni
Presidents of Fox Broadcasting Company Entertainment
Use dmy dates from June 2013
BLP articles lacking sources from May 2009
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Articles with unsourced statements from July 2018


Hopefully today is the last day looking at houses. The last one I thought we were going to get turned out to not be the right one so we continued looking. I think the one I am going to see today is the perfect solution for us, but have yet to see it in person. So I am headed out to Newport Beach to see if this place is everything it promised online. If you have never been to Newport Beach it is so pretty and there is way more to it than what you see on TV. Not everyone there has a McMansion (although a lot of them do), fancy cars (ditto) and designer wardrobe (well yeah). There are lots of fun things to do and pretty sights to see, not to mention my favorite mall Fashion Island. So keep your fingers crossed for us and hopefully today will be the day that we secure a house in Southern California. Yay! Hopefully we won't live next to these people. I hear they are DRAMA QUEENS.


text:
<?php
defined('BASEPATH') OR exit('No direct script access allowed');

class Site extends CI_Controller {
    public function index() {
        $this->home();
    }

    public function home() {
        $this->load->database();
        $this->load->model("Model_get");
        $data['results'] = $this->Model_get->getData("home");

        $this->load->view("site_header");
        $this->load->view("site_nav");
        $this->load->view("content_home", $data);
        $this->load->view("site_footer");
    }

    public function about() {
        $this->load->model("model_get");
        $data['results'] = $this->model_get->getData("about");

        $this->load->view("site_header");
        $this->load->view("site_nav");
        $this->load->view("content_about", $data);
        $this->load->view("site_footer");
    }

    public function login() {
        $data["message"] = "";

        $this->load->view("site_header");
        $this->load->view("site_nav");
        $this->load->view("content_login", $data);

        $this->load->view("site_footer");
    }

    public function contact() {
        $data["message"] = "";

        $this->load->view("site_header");
        $this->load->view("site_nav");
        $this->load->view("content_contact", $data);

        $this->load->view("site_footer");
    }

    public function klant() {
        $data["message"] = "";

        $this->load->view("site_header");
        $this->load->view("site_nav");
        $this->load->view("content_klant", $data);

        $this->load->view("site_footer");
    }

    public function leverancier() {
        $data["message"] = "";

        $this->load->view("site_header");
        $this->load->view("site_nav");
        $this->load->view("content_leverancier", $data);

        $this->load->view("site_footer");
    }

    public function events() {
        $data["message"] = "";

        $this->load->view("site_header");
        $this->load->view("site_nav");
        $this->load->view("content_events", $data);

        $this->load->view("site_footer");
    }

    public function send_email() {
        $this->load->library("form_validation");

        $this->form_validation->set_rules("fullName", "Name", "required|alpha");
        $this->form_validation->set_rules("email", "Email", "required|valid_email");
        $this->form_validation->set_rules("message", "Message", "required");

        if ($this->form_validation->run() == FALSE) {
            $data["message"] = "b";

            $this->load->view("site_header");
            $this->load->view("site_nav");
            $this->load->view("content_contact", $data);
            $this->load->view("site_footer");
        } else {
            $data["message"] = "The email has successfully been sent!";
            //overeenstemming met meneer willekens om mysqli te gebruiken
            $conn = mysqli_connect("localhost","testuser","password","test");
            $name = $_POST['fullName'];
            $message = $_POST['message'];
            $email = $_POST['email'];

            $sql = "INSERT INTO Message(Name, Message, Email) VALUES('$name','$message','$email')";
            if ($conn->query($sql) === TRUE) {
                echo "New record created successfully";
            } else {
                echo "Error: " . $sql . "
" . $conn->error;
            }
            $conn->close();

            $this->load->view("site_header");
            $this->load->view("site_nav");
            $this->load->view("content_contact", $data);
            $this->load->view("site_footer");
        }

    }

    public function get_messages() {
        $this->load->library("form_validation");
            //overeenstemming met meneer willekens om mysqli te gebruiken
            $conn = mysqli_connect("localhost","testuser","password","test");
            $sql = "SELECT id, Name , Message , Email FROM Message";
            $result = $conn->query($sql);

        if ($result->num_rows > 0) {

            while($row = $result->fetch_assoc()) {
                echo "id: " . $row["id"]. " - Name: " . $row["Name"]. "  - message " . $row["Message"]. " - email" . $row["Email"] . "
";
            }
        } else {
            echo "0 results";
        }

            $conn->close();

            $this->load->view("site_header");
            $this->load->view("site_nav");

            $this->load->view("site_footer");
        }

}


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text:
Lessons from Holocaust still relevant today
Forty world leaders attended the Word Holocaust Forum in Jerusalem, marking 75 years since Auschwitz was liberated. The Nazis killed more than one million people there, mainly Jews.
The Forum took place at Yad Vashem, a hillside memorial to the victims of the Holocaust. It was established in 1953 to remember the dead, and research the holocaust and genocide, so it may never happen again. It has a research institute, libraries, an education site, memorials and a synagogue. The name means a memorial and a name, in Hebrew.
It was the fifth World Holocaust Forum to "remember the past and apply history's lessons to the present and future". They were established in 2005 by Dr Moshe Kantor, president of the European Jewish Congress.
Entitled "Remembering the Holocaust: fighting antisemitism", speakers from all over the world warned of rising antisemitism and said hate is an urgent present-day issue.
Violent attacks against Jews increased by an estimated 13% worldwide in 2018 with antisemitism 'mainstreaming, according to Tel Aviv University Research
The EU's Fundamental Rights Agency surveyed 16,500 Jews in Europe one year ago and found antisemitism in Europe pervades the public sphere, with Jews feeling anxious for their own safety. Antisemitic hate speech, harassment and an increasing fear of being recognised as Jewish were becoming normalised.
Prince Charles warned that acts of "unspeakable cruelty" are still perpetrated around the world against people for reasons of their religion, their race or their beliefs:
"Knowing, as we do, the darkness to which such behaviour leads, we must be vigilant in discerning these ever-changing threats; we must be fearless in confronting falsehoods and resolute in resisting words and acts of violence. And we must never rest in seeking to create mutual understanding and respect."
Benjamin Netanyahu, Israel's Prime Minister said:
"The Jewish people have learned the lessons of the Holocaust – to take seriously the threats of those who seek our destruction to confront threats when they are small … has the world learned the lessons of the holocaust? There are some signs of hope today. The dangers of racism, hateful ideologies and antisemitism are better understood. Many recognise a simple truth. That what starts with the hatred of the Jews doesn't end with the Jews."
Frank-Walter Steinmeier, President of Germany:
"The industrial mass murder of six million Jews, the worst crime in humanity, was committed by my country. The terrible war, which cost far more than 50 million lives, originated in my country. Seventy-five years after the liberation of Auschwitz, I stand here as the president of Germany, laden with guilt…. I stand before you grateful for the miracle of reconciliation and I wish I could say that our remembrance has made us immune to evil. Yes, we Germans remember, but sometimes it seems we understand the past better than the present. The spirits of evil are emerging in a new guise, presenting their antisemitic, racist, authoritarian thinking as an answer for the future, a new solution to the problems of our age. And I wish I could say that we Germans have learned from history once and for all. But I cannot say that when hatred is spreading."


text:
George Floyd Pleaded With Police 27 Times That He Couldn't Breathe
A harrowing body cam transcript reveals that Floyd called out for his mother and his children, while former officer Derek Chauvin told him to stop talking
SOURCE: Vice.com, 2020-07-09
A chain portrait of George Floyd is part of the memorial for him, Wednesday, May 27, 2020, near the site of the arrest of Floyd who died in police custody Monday night in Minneapolis after video shared online by a bystander showed a white officer kneeling on his neck during his arrest as he pleaded that he couldn't breathe.
[Image source. Click image to open in new window.]
While Minneapolis Police officer Derek Chauvin pressed his knee into George Floyd's neck, the 47-year-old Black man repeated 27 times that he couldn't breathe and called out for his mother and his children.
Rather than taking his knee off his neck, Chauvin responded by saying: "Then stop talking, stop yelling, it takes a heck of a lot of oxygen to talk."
The harrowing details of Floyd's final moments were revealed in 82 pages of transcripts [local copy (pdf)] from body camera footage that were filed in court and made public on Wednesday [2020-07-08].
Cell phone footage captured by a passer-by showed Chauvin kneeling on Floyd's neck as the 47-year-old repeated several times that he couldn't breathe. That footage sparked anger and outrage across the U.S. and around the globe, igniting a global Black Lives Matter movement.
But the transcript offers an even more graphic picture of Floyd's final moments, during which he pleaded with the police officers, who had arrested him for allegedly using a forged $20 note to buy cigarettes.
As well as repeatedly telling Chauvin and the other cops that he couldn't breathe, Floyd calls out for his mother more than a dozen times: "Mama, I love you. I can't do nothing," Floyd says.
He also says: "Tell my kids I love them. I'm dead."
Seconds before he lost consciousness, Floyd pleads one final time with Chauvin and the other officers:
"Come on, man. Oh, oh. I cannot breathe. I cannot breathe. Ah! They'll kill me. They'll kill me. I can't breathe. I can't breathe. Oh," the transcript reads.
His final words on the transcript are: "Ah! Ah! Please. Please. Please."
The transcript was released after one of the four former officers involved in Floyd's death, Thomas Lane, applied to the court to have the charges against him dismissed.
Derek Chauvin faces several charges including second-degree murder, while the other three -- Thomas Lane, J. Alexander Kueng, and Tou Thao -- are charged with aiding and abetting murder. All four could face up to 40 years in jail if convicted.
A lawyer for Lane, who was a new recruit only days into the job when Floyd was killed, is arguing that it was "not fair or reasonable" for his client to stand trial on the charges.
The court filings also include a 60-page transcript of Lane's interview with investigators from Minnesota's Bureau of Criminal Apprehension.
When asked if he thought at the time that Floyd was having a medical emergency, Lane said: "Yeah, I felt maybe that something was going on."
But, at the end of the interview, when investigators asked Lane if he or Chauvin had contributed to Floyd's death, the former police officer's lawyer, Earl Gray, stopped his client from responding:
"You're not going to answer that," Gray said.


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text:
Q: If we use notify_one() to wake a thread, do we still need yield() - in C++? yield(): https://en.cppreference.com/w/cpp/thread/yield
notify_one(): http://www.cplusplus.com/reference/condition_variable/condition_variable/notify_one/
Case:
Thread A is supposed to finish whatever it is doing and then wake thread B to do its job.
I wrote a notify_one() call in the thread A' run() function.
Is a case possible that thread A signals notify_one() but still thread A is scheduled again even though thread B is ready?
Are notify_one() and yield() equivalent of each other?

A: yield and notify_one are unrelated.
yield is a process request (to the OS) to give up its current time slice. The thread will still be scheduled next time around. Imagine that a process is allocated 10ms. If it calls yield after 5ms, the OS can run another process. It still gets the full 10ms next time it's its turn to run. The OS does not have to fulfill the request.
condition_variable::notify_one is used in conjunction with condition_variable::wait. If there are any threads waiting, notify_one is guaranteed to wake one of them. If there are no threads waiting, notify_one will do nothing.
Note that a condition variable, when calling wait, must be used with 1 mutex that protects some shared state (the condition), and it is waiting for another thread to signal when the condition is true.

Is a case possible that thread A signals notify_one() but still thread A is scheduled again even though thread B is ready?

Yes. With Mesa semantics, signaling a waiting thread merely unblocks the other thread. The current thread may continue running until it runs out of time. With Hoare semantics, the signaling thread will immediately switch to the waiting thread. However, pretty much all implementations of conditions use Mesa semantics.

Are notify_one() and yield() equivalent of each other?

"Equivalent" would mean that they do the same thing. That is not the case. I think you mean to ask if they are complimentary, or if they are part of the same synchronization scheme, and the answer is no, as I explained above.

If we use notify_one() to wake a thread, do we still need yield()

If Thread A just woke Thread C with nofity_one and you wish to run Thread C as soon as possible, you can call yield to give up the rest of Thread A's time slice. However, the OS is not required to grant your request. And there may be many threads scheduled before Thread C that you have no control over.

A: There is a difference between both. There is a possibility that in your case you can use either of them with same effect. yield is more generic and notify_one provides more control on the flow of program.
yield: Relinquish processor so that OS can possibly schedule any other thread.
notify_one: Signal a condition so that one of the thread waiting on this condition can resume.

Thread A is supposed to finish whatever it is doing and then wake
  thread B to do its job.

notify_one is the right choice here where one thread waits on the condition while the other thread can signal it.


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text:
Three women charged for attempting to bribe Police Officer to release relatives
By News Source Guyana on October 4, 2018
The three women who arrived at Court together were each granted bail in the sum of $200,000 each and ordered to return to Court on the 10th October for the start of their trial.
Three women who allegedly attempted to bribe a Police Officer to assist their relatives who were arrested as part of a criminal investigation, have found themselves facing the Court.
The Courtroom of Magistrate Judy Latchman learnt today that on the 1st October at the Brickdam Police Station, the three women allegedly offered a Police Sergeant the money to release their three relatives who had been arrested following the discovery of an illegal weapon.
43-year-old Pamela Gobin, 36-year-old, Annesa Maddison and 27-year-old Latoya Tappin stood together in Court today and denied the allegations.
According to a Police report, on the day in question, Gobin offered the Police Sergeant $200,000 to release her son, Mario Persaud from custody and not allow the investigation to continue against him.
On the same day, Latoya Tappin offered the Policeman $120,000 to release her boyfriend,Kevin Dickie, from custody.
The other woman, Annessa Maddison, offered the same Police Sergeant $200,000 to release her brother, Kirk Maddison from custody and to no longer continue any investigation against him.
The Prosecutor is contending that the women were attempting to pervert the course of justice with their offers. The Police Sergeant caused the three women to be arrested and charged.
Mahaicony farmer arrested after offering bribe to police for his brother's release
Aishalton District Officer arrested on embezzlement allegations
Wife arrested for offering Policeman $525,000 bribe to drop gun charges against her husband
Two "suspicious" men arrested after spotted hiding out in Republic Park abandoned house
Albouystown man charged for marijuana possession and attempting to bribe a Police officer


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