"The only thing we have to fear is fear itself," said Franklin D Roosevelt at his inauguration as US President in 1933.
I think "the only thing we have to fear is the fear index itself" is a better description of where investors are at right now.
It's been a wild ride on Wall Street and beyond of the past week – the worst in two years for the S&P 500 – with the volatility causing many to ask if the bubble has burst and the equities bull market is over.
Instead, I believe the unusually sharp burst of volatility is largely the result of products and asset allocation strategies linked to the VIX, the so-called "fear index", rather than any major re-assessment of the fundamental outlook.
To be sure, investors are right to be more worried than before about inflationary pressures arising from improved global economic conditions, the associated upward revision on the future path of interest rates and how that in turn impacts the valuation of share markets.
However, I would suggest that these expectations haven't changed anywhere near as rapidly as market prices. Investment products linked to the VIX appear to have amplified the recent market adjustment.
And those that are not, such as fixed income and currency markets, experienced much more orderly changes.
The VIX measures the stock market's expectation of volatility implied by the price of option contracts on the S&P 500 index. Options enable investors to insure against large moves in the share market. When investor uncertainty rises, the share market becomes more volatile, the price of insurance through option contracts increases, and so the VIX index rises. The VIX index spikes at times of markets crisis. Hence the "fear index" moniker.
Initially the VIX was simply designed to provide a measure of expectations of volatility for the US share market. However, over time many derivative instruments and exchange traded products were developed that allowed investors to bet on the performance of volatility itself.
This has introduced the possibility of a destabilising feedback loop because there is often a requirement for these funds to quickly sell market exposure in response to a rise in volatility. This action can, in turn, push VIX even higher. That appears to have been the case this past week.
The growth in popularity of these volatility-linked products has been due to their strong track record in a world where investors are searching for high income with low risk.
The provision of insurance can be a profitable venture, especially if there is a strong demand and high insurance premiums as was the case for financial insurance in the aftermath of the Global Financial Crisis. And with investors believing that central banks were deliberately trying to suppress volatility, the VIX index was pushed down to historical lows, boosting the performance of these products.
However, more recently, given the growth in the supply of this insurance and the much-reduced premiums for its provision, these products were priced for disappointment and were susceptible to any surprise that pushed VIX higher.
A modest improvement reported last week on the outlook for wages and its impact on interest rate expectations produced an increase in fundamental share market risk. This appears to have triggered a risk cascade producing catastrophic losses in these products and several have been closed by their sponsors.
That probably doesn't quite represent the end of this episode because it is widely known that there is also a large amount of institutional money whose asset allocation depends on the level of equity volatility. These strategies tend to target an overall level of realised portfolio volatility so they systematically sell equities when volatility increases and buy when volatility decreases.
Given the extremely low level of volatility prevailing at the start on the year, these strategies will currently be at the top end of their permitted range of equity exposure. I'd expect their portfolio managers will quite likely be required to sell some equities in the weeks ahead because volatility is unlikely to fall back to very low levels any time soon.
Given that, many other investors may sit back waiting for evidence that these trades have cleared the market before they step back into their own discretionary strategies.
A few years ago, we did experience a few spikes in the VIX index related to uncertainty about economic developments in China. These episodes were short lived and market volatility quickly retraced to very low levels because investors were convinced central banks would continue to protect asset prices.
The difference now is that economic conditions have improved, and unconventional monetary policy is beginning to be withdrawn. So central banks may have a higher tolerance for some asset market volatility. In the language of the option markets "the strike price for the central bank put is now further out of the money".
Does any of this alter our assessment of the market outlook? Not really. We have, for some time, been anticipating a moderate increase in volatility as monetary policy shifts to a less accommodative phase.
Importantly, I don't interpret the recent developments as the market signalling a rise in the likelihood of an economic recession over the next 18 months, even if there is a modest tightening of credit conditions. Nor do I believe that many businesses will alter their investment plans in light of this bout of extreme market volatility.
In a few months' time, I expect that the debate in markets will again focus on critical fundamental issues - the outlook for growth and inflation, the trajectory of cash rates, asset market valuations, as well as any unfolding geo-political developments.


I'll Take a Wrap and a Pouch, to Go.
So I'm really getting into babywearing these days. I have a 3 month old now that loves to be held. I mean, he would have us holding him constantly if he could have his way. This has prompted me to become more interested in slings and babywearing. I knew that I wanted to "wear" Lennon when I started reading this blog, but I didn't realize that I would want to try out every different sling known to man. Well, I want a closet full of slings. I don't need a closet full, but it's totally addictive. Today I thought, "My sling doesn't match my outfit at all!" This is funny, because you should see me most days. Picture yoga pants, flip flops, and hair up in a messy bun. Hopefully when you're seeing me I've remembered to take a diaper bag with me, but now you can bet that I WILL have remembered a sling! Now I want my sling to match my concert t-shirt and my Jan Brady plaid pants. It's getting ridiculous!
On the left, is the Moby Wrap I got today (that's not me, in case you wondered!). I instantly liked this wrap. It's super easy to use once it's on. I know a lot of people are intimidated by the giant piece of fabric, but if I can use it, anyone can. It can be used with infants/toddlers from preemie-35 lbs., and it is extremely versatile. Just look at all the different ways you can carry your child!
I've also been using my ModMum pouch quite a bit. Lennon likes to be held facing out, and he is so content in the pouch! I didn't think I would dig the pouch, but this one is not only pretty to look at, but serves as an awesome perch for little L.
I also still really dig my ring slings from Rockin' Baby Sling (Strawberry Fields-so appropriate) & Bronwen Handcrafted. Be sure to check out Rockin' Baby Sling for the funkiest styles. Their fabrics are amazing-right up my retro alley! My light, silk ring sling from Bronwen will be perfect for summer.
I have not had the pleasure of owning one of her slings, but I just think that the owner of nest is rad, and you should buy a sling over at her store too!
To recap: babywearing is great, and I love having the chance to wear Lennon around in all these cool fabrics!
on my counters and not feel like my skin is suffering because of toxic ingredients when I wash my hands. The EPIC hand soap contains no petroleum solvents, no dyes and no respiratory or skin irritants. Hey, the way I see it, we have to start somewhere and if that means using eco-friendly soap and cleaning products, then have at it my friends!
You should also be aware that 100% of EPIC's after-tax profit is donated to environmental conservation, education, and research.
What is also lovely about BuyGreen is that they offer a breakdown on the products that they carry. Check out their standards for the EPIC Glass and Mirror Cleaner. I really like it that they offer this extra detailed information.
BuyGreen is all about making friends with mother nature and our beautiful planet.
Our mission at BuyGreen is to become your most trusted source for green products, offering the widest variety of quality products, the best information for consumers, and the most enjoyable shopping experience.
You will find more than just cleaning products at BuyGreen. You're going to find green living items from clothing to office supplies to tech gadget accessories.
*Laura recently reviewed Isabella's Dream, the I Dream Baby products which are also available from BuyGreen.
If you're "going green", then we highly recommend you bookmarking BuyGreen.com and visiting frequently.


* Correspondence: Kazuki Mochizuki . Tel: + 81-55-220-8829; Fax: +81-55-220-8829.
Recommended citation: Mochizuki K, Imai C, Sato N, Kubota T. The Role of Epigenetics in Developmental Programming and the Developmental Origins of Health and Disease. OBM Genetics 2017;1(4):008; doi:10.21926/obm.genet.1704008.
© 2017 by the authors. This is an open access article distributed under the conditions of the Creative Commons by Attribution License, which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is correctly cited.
A number of epidemiological studies have suggested that environmental stresses, such as malnutrition during the fetal period, can induce development of metabolic disorders, such as obesity, type 2 diabetes, and hypertension, and and even psychiatric disorders in later life. This theory model is known as the Developmental Origins of Health and Disease (DOHaD) theory, in which postulates that "epigenetic memories", involving DNA methylation, histone modifications and microRNA expression, are induced by environmental stresses during development. For example, the binding of transcription factors to cis-elements within the promoters and enhancer regions of genes induces demethylation leading to and subsequent histone acetylation and transcriptional activation. Several lines of evidence suggest that binding of bromodomain-containing protein 4 and positive transcription elongation factor B to acetylated histones within "gene body" regions initiates transcriptional elongation, and while histone H3K36 methylation and DNA methylation within "gene body" these regions terminates this transcriptional elongation. This new epigenetic model of the gene body regulation can be applied to the regulation of metabolic genes, which respond to carbohydrate signals and are associated with energy balance. Recent studies indicate that these new gene body epigenetic mechanisms, as well as the classical promoter/enhancer mechanism, are responsible for regulation of epigenetic changes found in offspring that have been exposed to malnutrition during the fetal period. In this context, further understanding of epigenetic gene regulation during the fetal period based on the "gene body epigenetic model" during the fetal period should provide new preventive and therapeutic strategies for adult diseases encompassed by DOHaD theory.
Lifestyle choices, including dietary habits, can lead to the development of metabolic diseases, including obesity and type 2 diabetes, hypertension, lipid abnormalities, metabolic syndrome, and associated complications. These lifestyle factors are also relevant in the development of psychiatric disorders. Recent studies have demonstrated that these metabolic diseases develop via accumulation of the consequences of lifestyle choices throughout life; not only during adulthood, but also during development, including the fetal period and childhood. Newborns with low birth weight (under 2,500 g) have a higher risk of death resulting from cardiovascular diseases , type 2 diabetes , and metabolic syndrome . In addition, a cohort study conducted in the Netherlands revealed a higher incidence of obesity among subjects born to women who had been malnourished during a period of famine in the Second World War than among their siblings who were not born during a time of severe food shortage . A cohort study conducted in China also showed a higher incidence of integration disorder syndrome among subjects born to women who had experienced malnutrition during famine than among the generations born before and after this period . In addition, in Japan, the number of newborns with low birth weight has increased rapidly in recent decades, while the average birth weight has decreased . Therefore, it can be speculated that the children born during recent decades in Japan have a higher risk of developing metabolic diseases later in life. One cause of this may be the adherence to extreme diets before and during pregnancy by Japanese women in recent years.
The Developmental Origins of Health and Disease (DOHaD) theory  postulates that a predisposition to metabolic diseases occurs through developmental programming that is regulated by exposure to environmental factors. Development of these metabolic diseases is considered to be caused by the long-term exposure of cells and tissues to environmental stimuli, such as hyper- or hyponutrition, during development as well as in adulthood. A candidate mechanism for the development of metabolic diseases is epigenetic memory of chromatin. The DOHaD theory is underpinned by epigenetics, rather than by changes in DNA sequence (genetics), because according to the DOHaD theory, diseases develop from stored memories of environmental stimulation during development. Here, we review the relationship between epigenetics and the developmental programming/DOHaD theory.
In general, transcriptional regulation is mediated via transcription factors bound to DNA sequences located upstream of the transcription initiation site, particularly at promoter and enhancer regions. Transcription is initiated by the binding of transcription factors to specific sites, known as cis-regulatory elements, located in promoter and enhancer regions. This binding recruits transcription initiation complexes containing the RNA polymerase II–TATA box binding protein to the TATA box, which subsequently activates the transcription initiation reaction (Figure 1A).
Figure 1 Genetic and epigenetic regulation. A) Genetic regulation. B) Epigenetic regulation.
Recent studies have demonstrated epigenetic regulation of transcription by DNA methylation of CpG dinucleotide-rich regions (CpG islands) in the promoter regions of genes. DNA methylation involves the addition of a methyl group to cytosine residues, particularly those within CpG islands. CpG islands hypermethylation leads to chromatin condensation by associating with heterochromatin binding proteins and DNA methyltransferases (DNMTs); this induces direct repression of transcription. Demethylation of CpG islands leads to the induction of transcription by altering histone modifications, such as acetylation, in enhancer/promoter regions (Figure 1B).
In contrast to the chemical modifications of DNA, those associated with chromosome histone proteins are rich in variety and include acetylation, methylation, phosphorylation, and ubiquitination (Figure 2). Histones form nucleosomes, which consist of a segment of DNA wound around a histone octamer containing two molecules each of H2A, H2B, H3, and H4. Methylation of histone H3 at lysine 4 (K4) generally confers transcriptional activation, while methylation of histone H3K9/K27/K36 and H4K20 is associated with transcriptional repression. Each histone methylation site can be mono-, di-, or trimethylated although, in general, transcriptional activation or repression is strongly associated with changes from mono- to trimethylation. Histone acetylation relaxes the chromatin structure by changing the histone charge. In addition, histone acetylation activates transcription by recruiting epigenetic "reader" or "writer" proteins. Reader proteins bind to sites of epigenetic modification and recruit a variety of complexes to chromatin, while writer proteins, such as histone acetyl-transferases (HATs), histone methyl-transferases, and DNMTs, induce epigenetic modifications of chromatin. Histone methylation does not alter the charge of histones, but induces changes in transcriptional activation/repression by recruiting methylated histone binding proteins (containing a chromodomain, tudor domain, plant homeodomain finger, or WD40 repeat domain) to the chromatin .
Figure 2 Histone modifications. A) Histone H2A. B) Histone H2B. C) Histone H3. D) Histone H4.
Heterochromatin is formed by enhancing the methylation of CpG islands mediated by DNMT bound to heterochromatin binding proteins on the methylated histones of CpG islands. In contrast, euchromatin is formed by the demethylation of CpG islands and subsequent histone acetylation mediated by HAT  (Figure 3). The induction of histone H3K4 monomethylation around the nuclear factor-κB gene by exposing primary human aortic endothelial cells to high glucose for a relatively short time (16 h) was reported to be maintained for 6 days when the cells were incubated under normal glucose conditions . Therefore, it is postulated that environmental factors prevailing during development can lead to a predisposition to diseases later in life that is controlled by epigenetics (Figure 4).
It is not fully understood how environmental factors, including nutrient availability during development, affect metabolic gene expression and subsequent development of metabolic diseases. The classic model involves binding of transcription factors to cis-elements located in promoter/enhancer regions. Transcription factor-associated HAT acetylates histones in promoter and enhancer regions, and subsequently, bromodomain proteins bind to the acetylated histones to induce the formation of transcriptional initiation complexes around the TATA box of the promoter region. Nutrients, such as vitamins A and D, as well as unsaturated fatty acids and their metabolites, are ligands for nuclear receptors [retinoic acid receptor, vitamin D receptor, and peroxisome proliferator-activated receptor (PPAR), respectively]  (Figure 5A).
Recent studies conducted by ourselves and others have demonstrated that histone acetylation around the gene body region is important for regulating the magnitude of transcription. Histone acetylation in the gene body region recruits an acetylated histone binding protein, bromodomain containing 4 (BRD4). This is subsequently bound by positive elongation factor b (P-TEFb), which is a cyclin T1–CDK9 complex. BRD4 and the associated P-TEFb complex on the gene body region enhance transcriptional elongation by phosphorylating RNA polymerase II at the second serine residue of the C-terminal domain [12,13,14] (Figure 5B).
DNA methylation in the gene body regions is positively correlated with transcription  and recent studies have demonstrated a relationship with transcriptional elongation. Transcriptional initiation is terminated by CpG islands located in the upstream region by DNMT3a, which is a subtype of DNMT3 (Figure 6A). On the other hand, transcriptional elongation is terminated by methylation of DNA in the gene body region . Histone H3K36 methylation induced by a histone methyltransferase, SET2, represses the transcriptional elongation reaction by reducing histone acetylation via recruiting HDACs on the gene body [17,18,19]. The methylated histone H3K36 recruits another DNMT, DNMT3b, to induce DNA methylation in the gene body region (Figure 6B). Thus, DNMT3a dysfunction leads to the disruption of transcriptional initiation by changing DNA methylation in the promoter/enhancer region, while dysfunctional DNMT3b leads to disrupted transcriptional elongation by methylation of DNA in the gene body region.
Figure 5 Epigenetics of the enhancer/promoter region and the gene body. A) Epigenetics of the enhancer/promoter region. B) Epigenetics of the gene body.
The epigenetic model of gene regulation based on histone modifications and DNA methylation in the gene body region explains the efficacy of mRNA synthesis. Our recent studies in rats have demonstrated that carbohydrate intake increases histone acetylation in the gene body region, rather than in the promoter/enhancer region, of carbohydrate metabolism-related genes, such as sucrose-isomaltase, sodium glucose transporter 1, and glucose transporter 5 in the small intestine [12,13], and fatty acid synthase in the liver during the suckling–weaning transition period . In addition, we have demonstrated that fructose-inducible genes related to fat accumulation, such as Cyp8b1, Dak, and Plin5, are regulated by BRD4 in the liver . Histone acetylation in the gene body region of adiponectin has also been reported to be accompanied by the induction of mRNA synthesis during the differentiation of 3T3-L1 adipocytes . Disturbance of the expression of these genes leads to metabolic diseases and animals exposed to low energy and low protein conditions during the fetal period show abnormal expression of genes regulated by BRD4 and/or histone acetylation in the gene body region; therefore, BRD4-driven gene body acetylation is implicated as an epigenetic mechanism for the development of metabolic diseases induced by the fetal nutritional environment. Indeed, heterozygous Brd4-knockout mice showed growth abnormalities, such as reduced adiposity and abnormal bone metabolism, similar to those of mice exposed to fetal malnutrition . Although there is little evidence supporting a role for the histone H3K36 in this process, our recent study demonstrated that a starvation signal induced H3K36 tri/dimethylation in genes expressed in the small intestine of Xenopus laevis .
Recent studies have also demonstrated that gene body epigenetics regulate pre-mRNA splicing. For example, one report described that alternatively spliced exons (ASE) were highly methylated and widely bound to a methylated DNA binding protein MeCP2, and ablation of which resulted in the induction of ASE-skipping in mRNA splicing . However, associations between pre-mRNA spliceosome and DNA methylation or MeCP2 have not yet been established. The relationships between pre-mRNA splicing and gene body epigenetics and between gene body epigenetics and DOHaD require further investigation.
Several animal studies have demonstrated that nutritional conditions during development disrupt epigenetic regulation later in life. For example, the expression of insulin and insulin promoter factor 1 (PDX1), which is a transcription factor for insulin expression in the pancreas, was lower in adult mice exposed to low energy in the fetal period compared with that in mice exposed to normal energy levels. Exposure to starvation conditions in the fetal period induced DNA methylation and histone H3K9 dimethylation, and reduced histone H3 acetylation in the promoter region of Pdx1. Malnutrition during the fetal stage repressed Glut4 gene expression in skeletal muscle, while H3K9 dimethylation, DNMT3a binding, and histone deacetylase (HDAC)1 and 4 were induced and histone H3K14 acetylation in the Glut4 promoter region was reduced . These results suggest that malnutrition during the fetal period reduces insulin activity and induces impaired glucose tolerance in epigenetic disorders of the pancreas and skeletal muscle  (Figure 7A).
A low-protein diet fed to mice during pregnancy led to DNA demethylation in the promoter/enhancer regions of Ppara, which encodes a transcription factor for lipid metabolism, in the liver and heart , and in the glucocorticoid receptor (Gr) in the heart  of their newborn offspring, resulting in increased Ppara and Gr expression.
In addition, a restricted protein diet fed to pregnant rats enhanced the expression of Dnmt1 in the liver of their newborn offspring . A cause of the reduced DNA methylation in the promoter/enhancer regions of Ppara and Gr in the offspring of protein-restricted mothers was reduced Dnmt1 expression. Folic acid supplementation in the pregnant mice led to improved DNA methylation in the upstream region of these genes in the offspring. However, Dnmt3 expression in the newborns was not affected by exposure of the pregnant mice to a protein-restricted diet. DNMT1 maintains DNA methylation by attaching the methyl group to the complementary strand of previously hemi-methylated DNA during replication, while DNMT3 is responsible for de novo methylation. Thus, protein restriction may lead to disruption of the maintenance of DNA methylation during cell division in a pregnancy. In addition, deficiency of choline, which is a nutrient associated with one-carbon and methyl-group metabolism, was shown to induce DNA methylation throughout the genome and around the insulin-like growth factor 2 gene (Igf2), accompanied by the DNA methylation around Dnmt1 . These results indicate that protein-restriction and deficiency of folic acid and choline during the fetal period induce epigenetic disruption in adulthood. Subjecting pregnant rats to protein-restriction led to fatty livers in the offspring . PPARA enhances the utilization of fat under conditions of reduced carbohydrate metabolism, such as insulin-resistance, while GR induces gluconeogenesis and fat accumulation. Excessive PPARA expression in the heart is associated with cardiac muscle disorders . Therefore, the induction of PPARA and GR expression in the heart and liver triggered by a reduction in DNA methylation around the genes encoding these proteins could lead to cardiac muscle disorders and fatty liver (Figure 7B). Regarding gene body epigenetics, DNA methylation in the gene body of liver X receptor A (Lxra) was reduced in the liver of F1 and F2 intrauterine growth-restricted mice . However, since most animal model studies focused on the epigenetics of promoter/enhancer regions, further studies are required to establish the relationship between the epigenetics of gene body regions and developmental programming/DOHaD theory.
The relationship between genomic imprinting and DOHaD is still unclear. However, the fetal environment has been confirmed to induce alterations in the expression and promoter DNA methylation of the paternally-imprinted IGF2 gene in humans and animals. Furthermore, expression of the paternally-inherited IGF2 gene is enhanced by DNA methylation of the differentially methylated region (DMR) located upstream of the adjacent H19 gene, which facilitates the access of proteins to an enhancer region. In contrast, in the case of the maternally-IGF2 gene, the DMR is demethylated and binding of the CTCF protein to this region inhibits the access of proteins to an enhancer region and inactivates the IGF2 gene . It has been reported that the DNA methylation of the DMR upstream of paternally-inherited H19 and IGF2 gene expression are lower in patients with Silver–Russell syndrome [29,30]. Therefore, the fetal environment could affect genomic imprinting, particularly that of the IGF2 gene, and alterations in genomic imprinting may affect the development of metabolic disorders and psychiatric disorders in newborns. However, this issue remains to be clarified in further studies.
Regarding psychiatric disorders, symptoms of schizophrenia, including hyperkinetic disorder, have been reported in the offspring of rats subjected to immobilization stress during pregnancy. Specifically, following the induction of DNA methylation in the promoter regions of the reelin and glutamate decarboxylase 1 genes, reduction of their expression and the induction of Dnmt1 gene expression in the frontal cortex were observed in the offspring of rats subjected to immobilization stress during pregnancy . This indicates that the development of psychiatric disorders which are induced by the fetal environment are caused by epigenetic defects.
In humans, it is not yet known whether the development of metabolic and psychiatric disorders induced by the fetal environment is regulated by epigenetic memory. A cohort study conducted in subjects born to mothers who had suffered malnutrition in the Netherlands during the Second World War showed that DNA methylation in the promoter region of IGF2 was significantly lower in the blood of subjects exposed to these conditions during early gestation compared with that detected in their siblings who had not . Methylation of the IGF2 promoter region was also found to be lower in lymphocytes isolated from umbilical cord blood of infants born to subjects with gestational diabetes than in those born to healthy subjects . In addition, DNA demethylation of the IGF2 promoter region in these cells was positively associated paternal obesity . However, the roles of IGF2 in the development of metabolic diseases are still unclear. An animal study showed that a high-fat diet fed to the offspring of rats exposed to a low-protein diet during pregnancy not only induced obesity and insulin resistance, but also upregulated expression of the Igf2 gene . Therefore, it can be speculated that exposure to environmental factors during human pregnancy induces metabolic and psychiatric disorders by altering the methylation of genes, including IGF2. It has been reported that carbohydrate restriction during pregnancy is positively associated with methylation in the promoter region of retinoid X receptor A (RXRA) in lymphocytes isolated from umbilical cord blood . In addition, the body mass index (BMI) of pregnant women is positively associated with methylation of the PPARγ co-activator 1α (PGC1A) promoter in their newborns . Methylation of the aryl-hydrocarbon receptor DNA promoter in newborns was also reported to be positively associated with maternal obesity during pregnancy, infant gestational age, and birth weight for gestational age . However, there is no evidence in humans that environmental factors during pregnancy alter the methylation of the GLUT4, PPARA, GR, and LXR genes that are affected in animal models. Despite the absence of reports of gene body epigenetic markers associated with metabolic disease development in relation to the developmental programming/DOHaD theory, several studies have been conducted focusing on promoter/enhancer regions. For example, methylation of the gene body region of the glucokinase (GCK) gene in peripheral blood samples was lower in subjects with coronary heart disease and higher in subjects with essential hypertension compared with that in healthy subjects [38,39]. A minor polymorphism in DNMT3B, which regulates DNA methylation in gene body regions, was also associated with an increased risk of premature birth . Thus, it is possible that disrupted gene body epigenetics is linked to developmental programming/DOHaD theory, although this hypothesis requires further examination. In addition, the relationship between histone modification and DNA methylation induced by the fetal environment has not been studied in humans. Further studies using peripheral and umbilical cord blood are required to clarify these relationships in humans.
In this review, we discuss two models of epigenetics based on the promoter/enhancer region and the gene body region. Several studies have demonstrated the existence of epigenetic memory in promoter/enhancer regions and in gene body regions in animals and humans exposed to environmental stress conditions, including malnutrition, during the fetal period as well as in adulthood. However, these findings are preliminary and further studies are required to elucidate the epigenetic mechanisms underlying the development of metabolic diseases associated with exposure to environmental stress during development.
We thank Dr. Ozato Keiko from the National Institute of Health for providing the chance to study BRD4. We thank Tom Buckle, MSc, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.
Our work cited in this review was supported by Grants-in-Aid for Young Scientists (22680054) and for Scientific Research (26282023, 17H01964) from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), the Takeda Science Foundation and the Uehara Memorial Foundation.
Gluckman PD, Hanson MA. The Developmental Origins of Health and Disease. Basic & Clinical Pharmacology & Toxicology. 2008;102(2):90.
Bruce Alberts AJ, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter. Molecular Biology of the Cell, 6th ed, 2015.
Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. The Journal of nutrition. 2005;135(6):1382-6.


text:
What the Future Looks Like: Scientists Predict the Next Great Discoveries―and Reveal How Today's Breakthroughs are Already Shaping Our World
By Jim al-Khalili
Read by Pete Cross
Jim al-Khalili Dreamscape
7.69 Hours • 04/17/2018 • Unabridged
1 Format: Digital Download
Every day, scientists conduct pioneering experiments with the potential to transform how we live. Yet it isn't every day you hear from the scientists themselves! Now, award-winning author Jim Al-Khalili and his team of top-notch experts explain how today's earthshaking discoveries will shape our world tomorrow—and beyond. Pull back the curtain on genomics, robotics, AI, the Internet of Things, synthetic biology, transhumanism, interstellar travel, colonization of the solar system, teleportation, and much more. And find insight into big-picture questions such as: Will we find a cure to all diseases? The answer to climate change? And will bionics one day turn us into superheroes?These scientists are interested only in the truth—reality-based and speculation-free. The future they conjure is by turns tantalizing and sobering: There's plenty to look forward to, but also plenty to dread. And undoubtedly the best way to for us to face tomorrow's greatest challenges is to learn what the future looks like—today.
Every day, scientists conduct pioneering experiments with the potential to transform how we live. Yet it isn't every day you hear from the scientists themselves! Now, award-winning author Jim Al-Khalili and his team of top-notch experts explain how today's earthshaking discoveries will shape our world tomorrow—and beyond.
Pull back the curtain on genomics, robotics, AI, the Internet of Things, synthetic biology, transhumanism, interstellar travel, colonization of the solar system, teleportation, and much more.
And find insight into big-picture questions such as:
Will we find a cure to all diseases?
The answer to climate change?
And will bionics one day turn us into superheroes?
These scientists are interested only in the truth—reality-based and speculation-free. The future they conjure is by turns tantalizing and sobering: There's plenty to look forward to, but also plenty to dread. And undoubtedly the best way to for us to face tomorrow's greatest challenges is to learn what the future looks like—today.
Author Bio: Jim al-Khalili
Jim al-Khalili is a quantum physicist, author, and broadcaster based at the University of Surrey in England. He received his PhD in theoretical nuclear physics in 1989 and has published more than a hundred research papers on the subject. He is a well-known presenter on British television and radio, and his many popular science books have been translated into more than twenty-five languages. He is a recipient of the Royal Society of London's Michael Faraday Prize and the Institute of Physics Kelvin Medal. In 2016 he received the inaugural Stephen Hawking Medal for Science Communication.
Available Formats : Digital Download
Category: Nonfiction/Science
Publisher: Dreamscape
Runtime: 7.69

redpajama_set_name: RedPajamaCommonCrawl


THE RETURN OF FINLANDS MOST EPIC BAND !!!
Epic Finish Pagan Metal leaders WYRD return with their most expansive and exhilarating album to date "Death Of The Sun"! Seven years in the making, the bands 9th album continues their exploration into Doom, Folk and Rock territories without sacrificing their Metal origins. From Doom rock verses to melodic acoustic passages filled with pagan sorrow to monstrously catchy choruses the band achieves an excellence rarely heard in the metal scene. Further WYRD utilizes a myriad of vocal styles to accentuate their vast and diverse musical sound-scape. All of which culminates in 9 esoteric heathen hymns of the Wyrding way !
* Highly anticipated 9th album from the Epic Finish Heathen Metal band !
* Features a killer production courtesy of Cursed Studios, DT Audio and Patologian Laboratoria (Wyrd, Azaghal, Svartkraft, Hin Onde).
* Beautifully dreary cover photo by Milos Anic.
* Features members of cult Finish acts Azaghal, Kalmankantaja, Svartkraft, Lathspell, Rutonkantaja & Vultyr!
* Multiple headlining Festival appearances and regional touring through-out 2016!
* The Perfect mix of Doom, Folk, Black Metal, Rock and Pagan music!
* Mandatory for fans of Agalloch, Katatonia, Azaghal, Drudkh, Horna, October Falls and Falls of Rauros!


text:
Survivor Series 2020 è stata la trentaquattresima edizione dell'omonimo evento in pay-per-view di wrestling organizzato dalla WWE. L'evento si è svolto il 22 novembre 2020 al Amway Center di Orlando (Florida).

A causa della pandemia di COVID-19, l'evento si è svolto con la sola presenza del personale autorizzato. L'evento è stato trasmesso inoltre dal WWE Thunderdome, dove, tramite una serie di pannelli a LED intorno all'arena, i fan da tutto il mondo hanno potuto assistere in diretta all'evento tramite collegamento remoto.

L'evento omaggiò, inoltre, il trentesimo anniversario dal debutto di The Undertaker alle Survivor Series 1990.

Storyline
Nella puntata di Raw del 26 ottobre furono annunciati tre match di qualificazione per il Team Raw: nel primo, AJ Styles sconfisse Jeff Hardy, nel secondo Keith Lee si qualificò sconfiggendo Elias e nel terzo Sheamus superò Riddle. Per le donne, invece, furono direttamente annunciate come parte del Team Raw Dana Brooke, Mandy Rose, Nia Jax e Shayna Baszler. L'ultimo membro del gruppo femminile, Lana, si qualificò sconfiggendo Lacey Evans, Nikki Cross e Peyton Royce in un Fatal 4-Way match. Nella puntata di SmackDown del 30 ottobre furono annunciati due match di qualificazione per il Team SmackDown: nel primo Kevin Owens sconfisse Dolph Ziggler e nel secondo Jey Uso ebbe la meglio su Daniel Bryan. Nella puntata di Raw del 2 novembre Braun Strowman si qualificò, sconfiggendo Keith Lee e Sheamus in un Triple Threat match. Nella puntata di SmackDown del 6 novembre furono annunciati due ulteriori match di qualificazione: Seth Rollins superò Otis e King Corbin sconfisse Rey Mysterio. Successivamente, Riddle fu l'ultimo componente ad aggiungersi al Team Raw, dopo aver sconfitto Elias e Jeff Hardy in un Triple Threat match nella puntata di Raw del 9 novembre. Per le donne, invece, Bianca Belair si qualificò vincendo un Triple Threat match che comprendeva anche Billie Kay e Natalya. Nella puntata di SmackDown del 6 novembre fu annunciato un ulteriore Triple Threat match di qualificazione tra Natalya, Zelina Vega e Ruby Riott, vinto da quest'ultima. Nella puntata di SmackDown del 13 novembre Liv Morgan vinse un Fatal 4-Way match per unirsi al Team SmackDown, a discapito di Chelsea Green, Natalya e Tamina. Nella puntata di Raw del 16 novembre Dana Brooke e Mandy Rose del Team Raw furono sostituite da Lacey Evans e Peyton Royce. Nella puntata di SmackDown del 20 novembre Otis fu scelto come ultimo componente del Team SmackDown maschile, mentre per quanto riguarda quello femminile si unirono anche Bayley e Natalya, con quest'ultima che sconfisse Tamina in un match di qualificazione.

Come ogni anno dall'edizione del 2017, furono annunciati i Champion vs. Champion match tra i campioni di Raw e SmackDown: il WWE Champion Drew McIntyre avrebbe affrontato lo Universal Champion Roman Reigns, lo United States Champion Bobby Lashley se la sarebbe vista con l'Intercontinental Champion Sami Zayn, la Raw Women's Champion Asuka si sarebbe scontrata con la SmackDown Women's Champion Sasha Banks e i Raw Tag Team Champions, il New Day (Kofi Kingston e Xavier Woods), avrebbero affrontato gli SmackDown Tag Team Champions, gli Street Profits (Angelo Dawkins e Montez Ford). Per quanto riguarda i due titoli mondiali, inizialmente, Randy Orton, detentore del WWE Championship nella puntata di Raw del 16 novembre, perse il titolo contro Drew McIntyre in un, No Holds Barred match, prendendone il posto nel match.

Il 21 novembre fu annunciata una Dual-Brand Battle Royal nel Kick-off dell'evento.

Risultati

Survivor Series Elimination match
Il rosso indica le superstar di Raw e il blu indica le superstar di SmackDown

Note

Collegamenti esterni

2020
Wrestling nel 2020

redpajama_set_name: RedPajamaWikipedia


text:
// Licensed to the .NET Foundation under one or more agreements.
// The .NET Foundation licenses this file to you under the MIT license.
// See the LICENSE file in the project root for more information.

using System.Diagnostics;
using System.IO;
using System.Threading;
using System.Threading.Tasks;

namespace System.Net.Http
{
    internal sealed partial class HttpConnection : IDisposable
    {
        private sealed class HttpConnectionContent : HttpContent
        {
            private readonly CancellationToken _cancellationToken;
            private HttpContentReadStream _stream;

            public HttpConnectionContent(CancellationToken cancellationToken)
            {
                _cancellationToken = cancellationToken;
            }

            public void SetStream(HttpContentReadStream stream)
            {
                Debug.Assert(stream != null);
                Debug.Assert(stream.CanRead);

                _stream = stream;
            }

            private HttpContentReadStream ConsumeStream()
            {
                if (_stream == null)
                {
                    throw new InvalidOperationException(SR.net_http_content_stream_already_read);
                }

                HttpContentReadStream stream = _stream;
                _stream = null;
                return stream;
            }

            protected override async Task SerializeToStreamAsync(Stream stream, TransportContext context)
            {
                Debug.Assert(stream != null);

                using (HttpContentReadStream contentStream = ConsumeStream())
                {
                    const int BufferSize = 8192;
                    await contentStream.CopyToAsync(stream, BufferSize, _cancellationToken).ConfigureAwait(false);
                }
            }

            protected internal override bool TryComputeLength(out long length)
            {
                length = 0;
                return false;
            }

            protected override Task<Stream> CreateContentReadStreamAsync() =>
                Task.FromResult<Stream>(ConsumeStream());

            internal override Stream TryCreateContentReadStream() =>
                ConsumeStream();

            protected override void Dispose(bool disposing)
            {
                if (disposing)
                {
                    if (_stream != null)
                    {
                        _stream.Dispose();
                        _stream = null;
                    }
                }

                base.Dispose(disposing);
            }
        }
    }
}

redpajama_set_name: RedPajamaGithub


Does your organization have a BYOD policy? If so, you probably have a good understanding of the Security+ testable concepts related to bring your own device (BYOD) policies. That's good because you'll find that the Security+ exam tests your understanding of mobile security concepts and technologies, including BYOD policies.
Q. Management within your company is considering allowing users to connect to the corporate network with their personally owned devices. Which of the following represents a security concern with this policy?
Many organizations are adopting bring your own device (BYOD) policies. These policies allow users to connect their own smartphones and tablets to the organization's network. Data security is a primary concern when allowing employee-owned devices onto a network, so different rules and guidelines are implemented to protect data. Additionally, there are several concerns that complicate these policies.
As an example, imagine that Homer has a tablet that he uses for email, Internet research, and various other personal uses. If his company allows him to connect this tablet to the corporate network, it will make it easier for Homer to access company email and other company resources needed for his job. However, is Homer's tablet protected from threats? Does it have antivirus malware installed? Does Homer keep it up to date with current patches? Who owns the data on the tablet? Who provides support if he has problems connecting to the network? Most of these issues would be addressed in an acceptable use policy, or in some cases a separate BYOD policy.
Acceptable use policy. Aacceptable use policy (AUP) describes user responsibilities when using an organization's IT resources. Employees are required to periodically read and acknowledge the contents of the policy. When used with a BYOD policy, the AUP will define the responsibilities of employees if they choose to connect their personal devices to the organization's network.
Adherence to corporate policies. If users are unwilling to adhere to the corporate policies, they are not allowed to connect their devices to the network.
Privacy. Users have a right to privacy, but not all activities are private. For example, it isn't appropriate for users to connect to the network for Internet access and then spend their time gambling. AUPs often include a privacy statement informing users what activities they can consider private.
User acceptance. These policies can potentially cause problems with some users. The attitude is that the device is their own, so the organization doesn't have any business managing it. However, when users understand the risks associated with unmanaged devices, they are often more willing to accept the policies. If users are unwilling to accept the policies, the organization simply blocks them from connecting their device to the company network.
Data ownership. Typically, the policy will specify that all data owned by the organization remains the organization's data. This normally includes email sent through the organization's network.
Support ownership. Support can be tricky. From a user's perspective, it's only one device. However, from the IT department's perspective, it is a multitude of smartphones and tablets. If the IT department must support them all, it can create a monumental workload. Because of this, many organizations limit the types of devices supported in a BYOD policy.
Architecture/infrastructure considerations. Instead of allowing users to have full connectivity with an organization's network, it is possible to segment these devices to a restricted access network. For example, many users want access to the Internet for email and web browsing, but don't necessarily need to connect to servers within the network. Organizations can set up VLANs that segment these users. The VLANs can have a path to the Internet with appropriate security, but block access to the primary network.
Forensics. Forensic analysts have tools to analyze mobile devices just as they have tools to analyze traditional computers. For example, they can identify deleted files. However, a company security specialist doesn't necessarily have permission to perform a forensic analysis on an employee-owned device.
Legal concerns. If an organization doesn't take the time to define BYOD, AUP, and privacy policies, it can result in legal issues. For example, if a user has been copying sensitive data onto an employee-owned device, the organization might face a lawsuit if it attempts to confiscate the device to remove the data. It isn't possible to avoid all legal issues with policies, but they go a long way to ensure people understand their responsibilities, and help avoid most legal issues.
On-boarding/off-boarding. On-boarding refers to the procedures to allow users to connect their devices to the network, and off-boarding refers to the procedures that remove the devices from the network. The most important consideration is simply to have established procedures. For example, having employees read and acknowledge the BYOD policy might be all that is required for on-boarding. When employees leave the organization, administrators remove all access to the network, including access with their mobile devices.
On-board camera/video. Mobile devices have excellent cameras that can take both still pictures and videos. These are useful and valuable. However, it also allows personnel to secretly take pictures and videos. They might take pictures of other employees, screen images, or confidential data. Organizations that support BYOD policies need to consider if they want to restrict the use of the camera, or merely define restrictions in an AUP.
Data security is a significant concern related to BYOD policies. You can use VLANs to isolate mobile devices from the primary network, while still granting them access to the Internet.
Answer is A. A core security concern with bring your own device (BYOD) policies is ensuring that they are up to date with current patches and have up-to-date antivirus signature files.
Tools are available to locate lost devices even if they are employee-owned.
The cost of the devices is not a security concern and not a concern to the company because employees pay for their own devices.
Although ensuring that the devices are compatible with network applications is a concern, it only affects availability of the application for a single user.
See Chapter 5 of the CompTIA Security+: Get Certified Get Ahead: SY0-401 Study Guide for more information securing mobile devices.


Acer palmatum Cutting propagation ?
Can I grow a Japanese Maple indoors?
Latest treatment for verticillium wilt?
Why is my maple turning green?
How do I grow Acers from seed, please ?
pruning a Japanese maple - when and how?
Difference between Acer Palmatum 'Bloodgood' and 'Atropurpureum' Japanese Maple?
Why is my "bloodgood" turning green?
What kind of Maple has dark red leaves in summer?
Pruning: good time to prune my Japanese maple?


text:
Rock and Roll Christmas
Rated TV-G. An estranged mother/daughter country music duo reunite after 10 years apart to release a Christmas single after a video of them goes viral.
TV-G. An estranged mother/daughter country music duo reunite after 10 years apart to release a Christmas single after a video of them goes viral.


text:
Skip to content A+ A-
Everything	Blog	Resource
Empowering women to lead
Leadership & Participation
Research, Policy and Advocacy
Equality Insights
Women's Action for Voice and Empowerment
Papua New Guinea & Bougainville
From the Movement
Our Staff / Board
IWDA Strategic Plan 2020-2023
Celebrating 19 years of economic empowerment
Dr Alice Aruhe'eta Pollard participating in the WAVE Inception Workshop, Melbourne, Australia.
WAVE is a ground-breaking women's leadership program that brings together and supports individual women, organisations, and movements in Asia and the Pacific region to increase the representation of women in diverse leadership positions.
In Solomon Islands, access to formal banking services outside of the capital and provincial capitals is non-existent. And with 80% of the country's population living in rural areas, this means a large proportion of residents have no access to basic financial services.
This is a particular challenge for women who, with no safe place to store their savings, are at increased threat of violence or theft. With no savings, women are often left dependent on their partners and have little control over how their money is spent.
That's where the West 'Are'Are Rokotanikeni Association (WARA) comes in. IWDA is proud to partner with this women-led savings club which brings women together to learn more about their finances, access small loans and build their financial literacy and management skills. It also provides women with a safe and secure place to store their savings and watch it grow.
Co-founded by Dr Alice Aruhe'eta Pollard in 1999, WARA now has more than 1000 members across West 'Are 'Are in Malaita Province.
The clubs meet regularly to learn skills such as financial literacy, household budgeting, basic bookkeeping, running a small business and good governance. Each club can use their pool of funds to loan money to members when they need it, and leaders are elected to keep records of deposits and loans.
But the savings club isn't just about money. It's an empowerment model that is driving transformational change.
Celebrating 19 years of savings
WARA members recently gathered at their annual general meeting to mark 19 years of the group's existence. Addressing members, the Premier of Malaita Province Peter Channel Ramo'ohau said the group's success was a model for others.
"With your hard work over the years and your dedications to your savings, now you are reaching the impossible by starting with the possible," he said.
At the annual meeting, members also learnt about important topics from business development and fighting corruption to ending gender-based violence.
Together, they have developed their voice and play an active role as decision-makers in their homes and communities, churches and chiefly structures.
Case study: West 'Are'Are Rokotanikeni Association, Solomon Islands
Article | 17.10.16
Intergenerational empowerment through savings clubs
Friday Feminist sHERO: Alice Aruhe'eta Pollard of WARA
Why Women
Learn about the Movement
News from the Movement
Invest in Women
Authorised by Bettina Baldeschi, International Women's Development Agency, Melbourne


text:
Our Vision and Values...
Our Staff Team 2021/2022
Information Security Incident Reporting Policy
List of School Governors
Link Governors
Governor Attendance
Governor Visit Policy
Letters from the Chair to the Parents (July 2021)
Letter from the Chair to the children (July 2021)
Our latest Ofsted report...
Safeguarding at LRPS
Safeguarding & Child Protection Policy 2021-2022
Child Protection Statement
Acceptable Use Policy 2021-2022
Confidential Reporting of Concerns (Whistleblowing Policy)
Let's talk PANTS!
Operation Endeavour
Welcome! Our Vision and Values Meet the Staff Covid Catch Up Strategy Edible Playground Extra Curricular FREE Breakfast for all children! GDPR Governors Job Vacancies at LRPS Latest Results Ofsted PE & Sports Premium Policies Pupil Premium Safeguarding Safeguarding at LRPS Safeguarding & Child Protection Policy 2021-2022 Child Protection Statement Acceptable Use Policy 2021-2022 Confidential Reporting of Concerns (Whistleblowing Policy) Let's talk PANTS! Operation Encompass Operation Endeavour School Meals
Safeguarding Children at Lemington Riverside Primary School
Lemington Riverside Primary School is committed to safeguarding and promoting the welfare of children and expects all staff and volunteers to share this commitment.
This means that we have a Safeguarding and Child Protection Policy and procedures in place. All staff (including supply staff, volunteers and governors) must ensure that they are aware of these procedures. Parents and carers are welcome to read the Policy on request.
Sometimes we may need to share information and work in partnership with other agencies when there are concerns about a child's welfare. We will ensure that our concerns about our pupils are discussed with his/her parents/carers first unless we have reason to believe that such a move would be contrary to the child's welfare.
Our Designated Safeguarding Lead (DSL) at Lemington Riverside is:
Craig Heeley (Head Teacher)
In the absence of the DSL, Chris Murphy, Rachel Turner, Vicky Jeffcock and George Sayers are the Deputy Designated Safeguarding Leads.
If you are concerned about a child's welfare, please record your concern, and any observations or conversation heard, and report to one of the Designated Safeguarding Leads as soon as possible the same day. Do NOT conduct your own investigation.
If your concerns relate to the actions or behaviour of a member of staff (which could suggest that s/he is unsuitable to work with children) then you should report this to one of the DSLs in confidence, who will refer the matter to the Head Teacher (or the Chair of Governors if the concern relates to the Head Teacher)– who will consider what action to take.


text:
..
 This work is licensed under a Creative Commons Attribution 3.0 Unported
 License.

 http://creativecommons.org/licenses/by/3.0/legalcode

==========================================
Bare Metal Trust Using Intel TXT
==========================================

https://bugs.launchpad.net/ironic/+bug/1526280

This uses Intel TXT[4], which builds a chain of trust rooted in
special purpose hardware called Trusted Platform Module (TPM)[3] and measures
the BIOS, boot loader, Option ROM and the Kernel/Ramdisk, to determine
whether a bare metal node deployed by Ironic may be trusted.

Problem description
===================
The bare metal tenant has the ability to introduce rootkits and other malware
on the host. Prior to releasing the host to a new tenant, it is prudent to
ensure the machine is in a known good state.

Using Intel TXT[4], the TPM[3], Trusted Boot[1], and remote authentication[2],
it is possible to confirm that the BIOS, boot loader, Option ROM, and the
Kernel/Ramdisk are all in a known good state.

Proposed change
===============
Add a new boot mode, trusted boot:

* Read value "capabilities:trusted_boot" from flavor. Pass boolean value
  "trusted_boot" to ironic.drivers.modules.deploy_utils.switch_pxe_config().
  Switch to "trusted_boot" section.

* Add a new section "trusted_boot" in PXE Configuration. It will make
  use of mboot.c32 which supports multiple loading. It loads TBOOT first.
  TBOOT will measure Kernel/Ramdisk before loading them.
  PXE config template::

    label trusted_boot
    kernel mboot
    append tboot.gz --- {{pxe_options.aki_path}} root={{ ROOT }} ro text
    {{ pxe_options.pxe_append_params|default("", true) }} intel_iommu=on
    --- {{pxe_options.ari_path}}

Alternatives
------------
Secure Boot[5] is used for the same purpose. The main difference is secure boot
will verify the signature before executing while trusted boot uses a hardware
root of trust and can be configured to verify each component before executing
or execute all components and capture "measurements" (aka extended hash
computations) for post verification. So if a node is changed, trusted boot will
still boot it up but give a warning to users. Secure boot will not boot it up
at all.

They are complementary, both making the cloud more secure. It is recommended to
boot nodes with secure boot under uefi and boot nodes with trusted boot under
legacy BIOS. The next step is to combine them together but that is out of the
scope of this spec.

Data model impact
-----------------
None

State Machine Impact
--------------------
None

REST API impact
---------------
None

Client (CLI) impact
-------------------
None

RPC API impact
--------------
None

Driver API impact
-----------------
None

Nova driver impact
------------------
Will pass the extra_spec "capabilities:trusted_boot=True" to Ironic

Ramdisk impact
--------------

N/A

.. NOTE: This section was not present at the time this spec was approved.

Security impact
---------------
Increased confidence in bare metal nodes being free of rootkits and other
malware. Intel TXT and TPM are leveraged.

Other end user impact
---------------------
None

Scalability impact
------------------
Our experiments indicate handling concurrent attestation requests is linear
in the number of requests. Attestation occurs on the node release path,
and thus is not latency sensitive.

Performance Impact
------------------
There is an extra attestation step during trusted boot which spends several
seconds. But for bare metal trust no dynamic attestation requests are
entertained. So this is a non-issue.

Other deployer impact
---------------------
* Create a special flavor with 'capabilities:trusted_boot=True'

* Set ``trusted_boot``:``True`` as capability in node.properties.

* Additionally two items need to be provided with tftpboot/httpboot folder
    - "mboot.c32" - Support multiple loading from /usr/lib/syslinux/mboot.c32
    - "tboot.gz"  - a pre-kernel module to do measurement.

* Set up each machine, enable Intel TXT, VT-x and VT-d and take ownership
  of the TPM, reboots, and captures the platform configuration register (PCR)
  values. This is to create the whitelist values that will be registered in
  the attestation service at initialization time.

* Set up an OAT-Server and create the whitelist with all known types of
  hardwares from previous step.

* Create customized images with OAT-Client.

* Run a customized script to verify the trust state of nodes when creating
  instances.

Developer impact
----------------
None

Implementation
==============

Assignee(s)
-----------

Primary assignee:
  tan-lin-good

Work Items
----------
  * Add trusted_boot section to pxe_config.template
  * Support trusted_boot flag and switch to trusted_boot.
  * A dib element to create customized images.

Dependencies
============
  * TBOOT[1]
  * OAT[2]
  * Hardware Support: TPM and Intel TXT

Testing
=======
Will add unit tests.
Planning on adding third party hardware CI testing.

Upgrades and Backwards Compatibility
====================================
None.
Backwards compatibility is achieved by not requesting "trusted"
bare metal. Custom tenant images are accommodated by deploying an initial
standard image that has the OAT client embedded. Today Fedora releases come
bundled with the OAT client. This solution approach, while increasing the
number of boots preserves us from having to doctor the tenant image by way
of injecting the OAT client into the same, or requiring that bare metal
users provide images with an OAT client included.

Documentation Impact
====================
Will document usage and benefits.
Here is a doc for the technical detail of Bare metal trust:
https://wiki.openstack.org/wiki/Bare-metal-trust

References
==========
1. http://sourceforge.net/projects/tboot/
2. https://github.com/OpenAttestation/OpenAttestation
3. http://en.wikipedia.org/wiki/Trusted_Platform_Module
4. http://en.wikipedia.org/wiki/Trusted_Execution_Technology
5. https://review.openstack.org/#/c/135228/
6. http://docs.openstack.org/admin-guide-cloud/compute-security.html#trusted-compute-pools


text:
Rodriguez Remodeling
Residential, Commercial, Multifamily Remodeling
John@RodriguezRemodeling.com
Multi-Family Remodeling
Other Areas Served
Shady Hollow
Reasons Why You Shouldn't Miss The Blanton Museum of Art
The Blanton Museum of Art is an iconic architectural landmark in Austin city of Texas. This museum houses a world-class collection from Pablo Picasso, Claude Monet, Vincent van Gogh and Andy Warhol. In addition to housing many famous pieces of art, this museum also offers interactive displays that allow visitors to explore the features of each element on display. For those interested in modern and contemporary art, there are no better options than the Blanton Museum! The Blanton Museum of Art in Austin, Texas, is a must-see for anyone who visits the city. The museum has a fantastic collection and great exhibits that will give you an appreciation for art like no other place can. Learn information about Austin, TX.
This excellent piece of history should be on everyone's list while visiting the area because it truly offers so much to its visitors, making it one of the most important cultural attractions in all of Texas. A visit to this beautiful museum allows people from all over the world to experience some fantastic pieces of artwork from artists worldwide – many of which have been featured at past exhibitions held within these walls! Blanton Museum of Art is one of the most visited museums in Austin, Texas. It has an impressive collection on display, including different styles which are unique to each other. Besides, the Blanton museum has an amazing architecture with exciting features that make it more attractive for all visitors from different parts of the world. If you plan your visit to Austin, Texas, don't miss this wonderful place where art lovers can find various art pieces available in many forms such as drawings, paintings, sculptures, etc. Discover facts about A Guide to What You'll Find in the Texas Capitol.
© 2023 Rodriguez Remodeling . All Rights Reserved.
Biz Web Shop


If you're looking for a quick getaway, head to Portland this Summer! It's only 3 hours from Seattle and has just the right combo of adventure and leisure…with more food than you can handle. And the best part – it's fun for every age.
We had the opportunity of staying at River's Edge Hotel & Spa, which is a gorgeous boutique hotel nestled on the riverfront, only a few minutes from downtown.
The hospitality and nature of their staff is kind and attentive. If you've read my previous travel posts, you know I love getting to know the front desk or concierge – they can make your trip much easier with tips and deals. Always be gracious to them and they will do the same.
Upon arrival we were greeted with a sampling of their best amenities – Local Wine, Chocolate-Covered Strawberries, and Cookie's for the girls. It's the little things that make a hotel more than just a 'place to stay.' You should feel comfortable, welcome and always a little spoiled when on vacation and they perfected it.
We arrived on Friday evening, just in time for Happy Hour at Aquariva – the farm-to-table, artisan restaurant adjacent to River's Edge Hotel.
We enjoyed cocktails and oysters on the terrace (which is riverside), followed by a delicious (& plentiful!) meal.
We finished the evening with a ride along the Greenway…Fun Fact: River's Edge Hotel provides complimentary bike rentals during your stay!
This is the largest continually operating outdoor arts and crafts market in the nation. Located in Portland's historic Old Town, the Market is the most popular shopping destination for local handcrafted goods.
This is our 6th design from The Patchery! Design an outfit with your little HERE! Use code OBSESSED15 to save 15%!
Regarded as Portland's finest specialty food shop and deli, Elephant's on Corbett came highly recommended (& so close to our hotel!). A definite gem in the South Waterfront District.
I suggest trying the new Elephant's Bloody Mary & a local, craft beer (because Portland is known for their breweries!).
Since the weather was fantastic all weekend, we opted for another patio meal – perfect when you have kiddos!
And if that wasn't enough, the Brunch Chef surprised us with their infamous Dutch Baby for dessert. #WhenInPortland!
In lieu of this delicious culinary escapade (aka a typical day in Portland), I opted to spend our last morning in the Spa & Fitness Center at River's Edge. They offer complimentary Group Fitness Classes daily, so after a relaxing hour of yoga, I enjoyed a dip in the private jacuzzi and a few bonus minutes in the steam room. The trip made a full circle and ended on a beautifully, rested note.
I hope our adventure has you eager (& hungry) to venture to the City of Roses – Portland, Oregon. p.s. It is one of only three states of the contiguous United States to have a coastline on the Pacific Ocean. Whether you prefer mountains, forests, waterfalls, beaches or lakes, Oregon should be at the top of your road trip list this Summer!
And if you're looking for a new road trippin' ride – check out the Toyota 4Runner. We borrowed the TRD Pro, which is their adventure series, for our drive to Portland. It fit our family of 4 + tons of cargo space (including 4 bags + 2 kid bikes!).
Disclosure: River's Edge Hotel & Spa, Elephants on Corbett, Toyota & The Patchery graciously provided product/services to try and review. The opinions expressed here represent my own, which I take great pride in providing pure honesty…because I'm OBSESSED with sharing the Good!
Going in two weeks! Thanks for the recs!
Fun! Where are you from?
Other fun places in Portland – food trucks, Voodoo doughnuts, and Powell's City of Books!
Oh yes! Last time we were in Portland we definitely hit all of those! Thanks for sharing!
Everything about your trip looks amazing!! Love the complimentary bike rentals!!!
My hometown! I live here and it's always so interesting to see Portland through other people's eyes and see where they stay, drink, and eat. Sounds like you had a nice trip! Love how close Portland and Seattle are to each other! I head up to Seattle at least a few times each year.
How fun! What are some of your favorites's in the city?
I've been wanting to go to Portland for a while but now I definitely need to go! All of the food looks sooooo good!
Love these ideas – we've seen River's Edge but never stayed there, so will have to keep it in mind! We love the Saturday market too!
I love this post! It looks like you all had so much fun and I'm definitely inspired to go out and explore more of the PNW.
We love traveling down to Portland, so it's fun to see new (to us) restaurant recommendations–looks like you found some excellent spots!
Portland is one of my favorite cities and your photos capture this amazing city so perfectly. Love.
You are so sweet! I hope you have a chance to return soon!


text:
package com.intellij.util.containers;

import org.jetbrains.annotations.NotNull;

import java.util.Collection;
import java.util.Iterator;
import java.util.List;

/**
 * Implementation of the {@link List} interface which:
 *

 *
Stores elements using weak semantics (see {@link java.lang.ref.WeakReference})

 *
Automatically reclaims storage for garbage collected elements

 *
Is thread safe

 *
Is NOT RandomAccess, because garbage collector can remove element at any time

 *
Does NOT support null elements

 *

 */
public class WeakList<T> extends UnsafeWeakList<T> {
  @Override
  public boolean add(@NotNull T element) {
    synchronized (myList) {
      return super.add(element);
    }
  }

  @Override
  public boolean addAll(@NotNull Collection<? extends T> c) {
    synchronized (myList) {
      return super.addAll(c);
    }
  }

  @Override
  public boolean addIfAbsent(@NotNull T element) {
    synchronized (myList) {
      return super.addIfAbsent(element);
    }
  }

  @Override
  public void clear() {
    synchronized (myList) {
      super.clear();
    }
  }

  @Override
  public boolean contains(@NotNull Object o) {
    synchronized (myList) {
      return super.contains(o);
    }
  }

  @Override
  public boolean remove(@NotNull Object o) {
    synchronized (myList) {
      return super.remove(o);
    }
  }

  @Override
  public boolean removeAll(@NotNull Collection<?> c) {
    synchronized (myList) {
      return super.removeAll(c);
    }
  }

  @Override
  public boolean isEmpty() {
    synchronized (myList) {
      return super.isEmpty();
    }
  }

  @Override
  @NotNull
  public Iterator<T> iterator() {
    final Iterator<T> iterator;
    synchronized (myList) {
      iterator = super.iterator();
    }
    return new Iterator<T>(){
      @Override
      public boolean hasNext() {
        synchronized (myList) {
          return iterator.hasNext();
        }
      }

      @Override
      public T next() {
        synchronized (myList) {
          return iterator.next();
        }
      }

      @Override
      public void remove() {
        synchronized (myList) {
          iterator.remove();
        }
      }
    };
  }

  @NotNull
  @Override
  public List<T> toStrongList() {
    synchronized (myList) {
      return super.toStrongList();
    }
  }

  @NotNull
  public List<T> copyAndClear() {
    synchronized (myList) {
      List<T> result = toStrongList();
      clear();
      return result;
    }
  }
}


text:
China's eSports Craze Reaches New Heights with the Victory of "Invictus Gaming" (IG)
The hashtag "IG are the Champions" received over a billion million views on Weibo over the past week.
Gabi Verberg
Over the past week, hotlists of Baidu and Weibo were dominated by the news of China's IG team winning the League of Legends (英雄联盟) World Championship for the first time in world history. Following China's success at the previous Asian Games, China's electronic-sports (esports) craze has now reached new heights.
In early November, 'Invictus Gaming' (IG) became the first Chinese team to win the League of Legends World Champions.
In a sold-out Munhak Stadium in Incheon, South Korea, the Chinese team took down Europe based FNATIC by 3-0 on November 3rd.
League of Legends is an online multiplayer video game developed and published by Riot Games in 2009 in which a team of players has to battle against the opposing team by gaining more strength through the accumulation of items and experience over the course of the game.
College Craze over IG
During the finals and in the days that followed, the internet flooded with reactions from esports enthusiasts. On Weibo, hashtags such as "IG are the Champions"(#ig冠军#)and "What the championship of IG means" (#IG夺冠的意义#) went viral, together scoring more than 1,5 billion views. IG's World Championship has shown, more than ever, how booming esports actually are in China.
During the finals, many photos and videos of school canteens, sports field and internet café's full of young people watching the final circulated on the internet.
Right after IG defeated FNATIC, videos posted online by students of the Nanchang Institute of Technology, Tianjin Institute of Technology, and many other universities showed countless dormitory rooms with students celebrating, cheering and chanting "IG are the Champions!" (IG冠军!).
At one university, several students even put up a banner reading: "If IG wins the championship, Unit 310 goes naked" ("IG夺冠!310集体裸奔"). Photos and videos later confirmed that some people partly held themselves to the agreement, showing young men wearing nothing but their underwear running around holding the IG's flag.
Over the past week, photos of banners hanging from university dormitories, congratulating IG, also spread online – showing a craze that is similar to that over football fever in some other countries.
The IG Fever Meme Machine
The craze over the IG victory has triggered dozens of memes on Chinese social media over the past week.
One of these memes involved Chinese businessman Wang Sicong (王思聪), son of billionaire Wang Jianlin. With more than 38 million Weibo followers, Wang Sicong @王思聪 is not only a popular Weibo blogger – he is also the founder of the current 'Invictus Gaming' team by acquiring top Chinese gaming club 'Catastrophic Cruel Memories' in 2011, in order to promote professional eSports in China.
Wang was spotted eating a large hot-dog during the games, in somewhat uncharming way, sparking a range of memes.
Some copied the image of Wang eating the hotdog in art..
…but the meme also went from online to offline as some companies used it to promote their food or products.
The trend went so far that the hashtag "Wang Sicong's Hotdog-Eating Image" (#王思聪吃热狗头像#) received over 380 million views, and that the businessman even asked his followers on Weibo to stop sharing his hotdog picture.
As reported by Radii, Wang Sicong also went viral for revealing that he would be selecting 113 fans (11.3 is the date IG won) to receive 10,000RMB ($1440) each, choosing the winners on 11.11 Single's Day.
At time of writing, that post had attracted a staggering 17 million comments.
But there were also other types of memes on Weibo this week, namely, those making of fun of the many people who had never heard of IG before and were surprised with the online craze surrounding the championship.
Netizens used self-irony in depicting themselves feeling like some kind of Neanderthal when hearing people discussing the IG championship…
Or by depicting two monkeys with a big "Congratulations IG" above them and one wondering "What is IG?!", and the other telling him just to follow the rest in congratulating them anyway.
This response also shows that China's post-70s and post-80s are not as familiar with the latest esports craze as China's younger (post-90s, post-00s) generations are.
A Momentous Victory
The enormous hype over the World Championship of the Chinese team shows that there is more to the topic than the victory the five IG players alone. Many esports fanatics see the Chinese teams' success as a crucial moment of recognition of esports in the PRC.
After IG was crowned world champion, the hashtag "What the Championship of IG Means" (#IG夺冠的意义#) received over 530 million views, with many Weibo users liking and sharing the following text:
"Perhaps middle-aged and elderly people don't know what just happened, but the Chinese team won the LPL world championship. After seven unsuccessful years, the Chinese teams have been under tremendous pressure from the public. […] But now IG is the world champion. Why do people hear the cheers of young people outside? Because we are the teenagers that were never understood, but now at this very moment, we got our recognition."
In conclusion, some facts & numbers:
● The first professional League of Legends world competition was held in 2011 in Sweden.
● League of Legends is considered to be the largest electronic sport in the world, being the most played game in the world for three consecutive years since 2016.
● In 2018, an estimated 81 million people worldwide played League of Legends each month.
● During the 2018 world final, a record was set with 205,348,063 viewers watching the game at the same time. 203.389.444 of these viewers were Chinese.
● The total prize money of the 2018 LPL world championship was $2,250,000.
● The 12 Chinese competing players altogether earned $556,875 prize money.
● Invictus Gaming won $843,750 prize money. The money was divided equally amongst a total of six players, meaning every player earned $140,625. (Note: the team also received bonuses from other third parties).
By Gabi Verberg and Manya Koetse, with contributions from Miranda Barnes
Related Topics:china popular culturechina sportsSina WeiboWeibo trending
This Is the Weibo Post with the Most Comments Ever (Well, Almost)
Insights into Sesame Credit & Top 5 Ways to Use a High Sesame Score
Gabi Verberg is a Business graduate from the University of Amsterdam who has worked and studied in Shanghai and Beijing. She now lives in Amsterdam and works as a part-time translator, with a particular interest in Chinese modern culture and politics.
ChongChing Mayor
Lmao… what dose their victory have anything to do with you? You are still video-game-playing losers, awarding professional players by your money.


Georgia's Physician Assistants (PAs) are medically trained and licensed to provide high quality health care, treat illnesses, plan prevention strategies, and write prescriptions. PAs practice medicine as part of a physician-directed medical team, and over 4,000 PAs in Georgia are making health care more accessible every day.
PAs boost patient satisfaction levels in practices, clinics, and hospital settings. In fact, studies conducted by the Kaiser Permanente Center for Health Research found patient satisfaction levels with PAs high, ranging in the 90th percentile.
This is because with PAs on staff, patients are in the waiting room for less time, and patients receive more attention, in many cases, for longer periods of time.
PAs improve the quality of health care because they can spend more time with patients, serving as health educators in addition to treating medical conditions. PAs can help plan prevention strategies with patients, such as nutrition and exercise programs for weight loss, hypertension, and diabetes. They can also help patients quit addictive habits, like smoking.
PAs make health care more accessible through extended office hours. Some PAs offer extended office hours so that working people and their families can come in at night or on weekends. PAs sometimes run health care clinics or practices in rural areas where physicians are not plentiful. All PAs work as part of a physician-directed medical team, and are able to consult with a physician if necessary.
Like doctors, PAs can specialize in different areas of medicine such as pediatrics, obstetrics and gynecology, dermatology, and surgery.
PAs are knowledgeable and professional health care providers. They are certified medical professionals, training on the same medical model as physicians. Many PAs have worked in the health care industry for several years before becoming PAs, and have extensive health care experience. PAs are required to participate in continuing education to keep their licenses, and are always learning more about conditions, diseases, cures, treatments, pharmaceuticals, and more.


Women's basketball player Morgan Mauro and wrestler Ryan Joint had breakout performances during the month of December on the way to earning Student-Athlete of the Month honors.
Mauro, a sophomore shooting guard from Des Moines, Iowa, averaged 8.7 points and 3.5 rebounds iin six games during the month. She made better than 50 percent of her 3-point attempts, going 16-for-29 (55.2 percent). She reached double figures in three straight games and made a career-high six 3s against Mount Mercy. She went 6-for-7 in that game, giving her the top 3-point shooting percentage (85.7) by a Simpson player in a game since 2008.
Joint, a freshman from Stuart, Iowa, led the Storm with a 5-3 record during the month. He went 2-1 in dual competition and closed the calendar year with a team-best 9-5 record. Three of his five wins came by pinfall. Joint went 3-2 in a stacked 149-pound division at Simpson's Luther L. Hill Invitational early in the month.


text:
HomeIndiaMumbai: 2 arrested for assaulting ward boy, vandalising civic hospital
Mumbai: 2 arrested for assaulting ward boy, vandalising civic hospital
The Dindoshi Police has arrested two men for allegedly creating ruckus inside a municipality hospital in Malad (East), breaking glasses of the OPD ward and main door, and assaulting a ward boy. The accused, including one in an inebriated state, suspected that their patient — who was stable — was not being treated properly, said officials on Thursday.
The complainant — a doctor from MW Desai hospital in Malad (East) — said in the FIR that the incident took place at around 4 am on Wednesday.
The two accused — Vishal Chikne (28), a relative of the patient, and his friend (details not shared by police), along with two women, had come to the hospital with a patient — identified as Pravin Chikne (40), who was suffering from hypertension, cold and fever — on Wednesday. Chikne was taken to the OPD ward and was given primary treatment. Suddenly, one of the two accused started clicking photographs, and as a doctor asked him not to do so, he said, 'Mala municipality hospital var bharosa nahi me vat lavin (I have no faith in the municipal hospital). I will cause damage.'
According to the doctor, he called the security and asked to take the man out of the hospital as he seemed inebriated. In the meantime, the two accused got into a heated argument with ward boy Dipesh Shinde, and assaulted him. Shinde bolted the OPD ward's door, and even as one of the two women accompanying them tried to stop them, the duo threw stones at the hospital and broke the glass of the OPD ward's window and the hospital's main door, and eventually escaped.
Police were informed about the incident, and the accused were booked under relevant sections of the Indian Penal Code (IPC), Prevention of Damage to Public Property Act, and the Maharashtra Medicine Service Persons and Medicare Service Institutions Act at the Dindoshi police station. The duo was traced, and arrested on Thursday.
mumbai crime news
Mumbai hospital staff assaulted
Mumbai hospital vandalised


text:
Home Entertainment The Society: Has Netflix Canceled The Series For Season 2
The Society: Has Netflix Canceled The Series For Season 2
Niranjan
August 25, 2020 1:00 pm EDT
The show gets cancelled along with other series' due to COVID-19
The curse of the coronavirus pandemic has hit The Society as the show gets axed a year after announcing Season 2. The network's decision comes as a surprise to many considering the show received rave reviews from critics and audiences alike.
Owing to complications with filming under the new safety guidelines, Netflix's The Society gets the chop along with I Am Not Okay With This.
The Society was eyeing a return in September to production but the uncertainty around production, balancing the needs and scheduling availabilities of the large cast and increased budget because of the new safety guidelines, the network had no option but to cancel the show.
In a statement, the streaming giant thanked Chris Keyser, Marc Webb and Pavlina Hatoupis for the show along with the writers, casts and crew members who worked tirelessly to make the show.
Keyser co-created and was the executive producer with director Marc Webb who has previously directed films such as 500 Days of Summer and The Amazing Spider-Man.
no one to save us, but us.
A post shared by The Society (@thesociety) on Apr 11, 2019 at 7:00am PDT
Starring Kathyrn Newton, The Society revolves around a group of teens who are mysteriously transported to a facsimile of their wealthy New England town and find out that all the adults are missing. With no trace of their parents, the group is forced to take matters into their own hands. Survival calls for alliances as they struggle to figure out what happened and how to get home.
The show takes a modern approach towards William Golding's 1954 novel, Lord of the Flies.
Apart from Kathyrn, other cast members are Gideon Adlon, Sean Berdy, Natasha Liu Bordizzo, Jacques Colimon, Olivia DeJonge, Alex Fitzalan, Grace Victoria Cox, Emilio Garcia Sanchez and Olivia Nikkanen.
WILDLIFE. WILDERNESS. WILDIN. go on a lil road trip with the cast at the link in bio 🐻
A post shared by The Society (@thesociety) on May 17, 2019 at 11:10am PDT
Newton took to Instagram to express her grief with co-star Adlon. She said: "I'm heartbroken, so heartbroken. Everything was written. I can't even believe it.
Newton continued: "I'm sorry we left it on such a cliffhanger; we didn't want that."
Adlon added: "It's definitely a bit of a gut-punch. It's a big bummer. But this is the way things work sometimes. We have no control over it."
Fan's Protest:
The sad news has shocked fans all around as the series ended on a huge cliffhanger and many questions are left unanswered.
Around 13,305 of 15,000 people have signed a petition to save the show. #Savethesociety trended on Twitter with many fans demanding the network for answers.
Netflix has earlier saved shows after announcing the cancellation, such as Lucifer, Unbreakable Kimmy Schmidt, Designated Survivor, Arrested Development and The Killing. Hopefully, this time around the fans too would change the network's mind.
Other show to also receive the axe:
Based on Chuck Forsman's graphic novel I Am Not Okay With This, the dark coming-of-age story too was cancelled owing to the pandemic. Whilst there was no official announcement regarding season two, the scripts were already completed for the sophomore run.
Read more: Aquaman 2: New Updates revealed by Director James Wan at DC Fandom
Previous article"Bayern Munich – A Lethal Force" All about their stunning performance This Season
Next articleTools Which Enhance Your Netflix Experience, List Here It's only smooth sailing from here on out for binge-watchers


text:
But at this point, what else could be done?
Everyone took a deep breath and began to do what Thomas said, preparing silver needles, serum making equipment and related drugs.
"The first patient must select the individual in the most severe condition!"
Treatments were given to critical patients first, then only less severe patients.
Even though they were able to stay alive for up to 24 hours, it was only a rough estimate. The only certainty was that those in critical conditions would die much sooner than those who were less severe. Therefore, Thomas's strategy was to treat the critical patients gradually and move on to the others.
The first patient that was carried over was a nearly 70-year-old man who was bitten by the two-headed snake while watching TV at home, because he was already old and had various medical conditions, with the addition of the snake venom, would not even give him a life expectancy of 2 hours, let alone 24 hours.
For such a patient, doctors need to race against the clock to save his life.
Thomas took a deep breath, relaxed his mind, and began treating the old man with needles.
One after another, silver needles were inserted into the old man.
The old man' s breathing gradually began to become weaker. When the tenth silver needle was inserted into his body, the old man stopped breathing. His heartbeat and pulse had stopped.
The old man was dead.
The son, who was watching from the side, abruptly jumped up, put his hands on his head, and yelled, "Dad, Dad!"
He thought the old man was really dead.
"Didn't you say you could cure my dad? Why have you killed him?"
"Quack doctor, you quack doctor!"
The son rushed up and was about to punch Thomas. However, Thomas immediately held at his throat, without even looking at him, and said to the doctor beside him, "The snake venom has stopped moving. Collect samples and make the serum, quick!"
"Roger!"
Doctors and nurses rushed over and did what Thomas said.
They were also carefully observed while collecting samples. The old man was indeed dead, as his heartbeat and breathing had both stopped. Was it really necessary to make a serum for an older man in such a state?
They muttered secretly in their hearts, not daring to speak out.
In fact, Thomas felt a little nervous himself.
If the person who was lying there was a 20-year-old, physically fit young man, he had nothing to be concerned about. The difficulty was that the old man himself was old, frail and sick
The timing of the pseudocide technique has to be strictly controlled. Even the slightest error could lead to the old man's death. There would be no second patient willing to allow Thomas to treat him if the first patient died. Even though Thomas had a solid grasp of the ability to save lives, it did not help.
In the current critical situation, there were some irrational people who came and messed around, causing havoc.
This scene was seen through the eyes of the undercover, which was arranged by Lord Vedastus, using a camera to secretly capture everything and send it to the news media under Lord Vedastus.
This time, there was some drama to watch.
The unscrupulous quack doctor falsely claimed to be able to cure snake venom, but he failed to save the innocent old man and killed him inadvertently. He even beat and kicked the old man's family!
The eye-catching and powerful news soon spread around on social media. In a flash, the number of people sharing and reading the news had surpassed ten million.
The entire public opinion environment was unfavorable to Thomas. He has completely become a sinner!
People began questioning and cursing Thomas after the news was known by the patients' families in the hospital and they were ready to take their injured families away, determined not to be treated by this kind of quack doctor.
What was even more exaggerated was that the police received a large number of calls and had no choice but to dispatch officers to arrest the quack Dr. Thomas.
This time, Thomas was in hot soup!


On the motion of the Environmental Committee, the first reading of the Bill on Amendments to the Water Act and the Taxation Act (319 SE), initiated by the Government, was concluded. The initiation of the Bill was necessitated by obligations assumed by Estonia under international maritime law agreements. The purpose of the Bill is primarily to establish the provisions necessary for the prevention of pollution caused by dumping at sea. Dumping means discharging substances or materials into the sea with the aim of disposing of them, and because of this aim, the substances and/or materials intended for dumping are considered as wastes in international law. In addition, the Bill specifies the provisions concerning the issue of the permit for the special use of water, dredging of water bodies and making of payments to international funds for compensation for pollution damage. The Estonian Centre Party Faction moved to reject this Bill at the first reading; 12 members of the Riigikogu voted in favour and 47 voted against. Thus, the motion to reject was not supported and the Bill was sent to the second reading.
Due to the end of the working hours of the sitting of the plenary assembly, the first reading of the Bill on Amendments to the State Legal Aid Act (271 SE), initiated by the Estonian Centre Party Faction, was adjourned. The deliberation will be resumed on Wednesday, 5 December, at the sitting beginning at 2 p.m.
On the motion of the Legal Affairs Committee, the Bill on Amendments to the Code of Enforcement Procedure and the Bailiffs Act (309 SE), initiated by the Government, was not deliberated at today's sitting.


text:
Is it Easier to Become a Police Officer With a Criminology Degree?
Men and women from all walks of life choose to pursue a career as a police officer. People who want to protect the community, earn a competitive compensation, and have an opportunity to retire at an early age tend to pursue work in the police force.
What Are Some Desirable Qualities of Police Officers?
City leaders and police department officials usually focus on finding candidates with qualities that include good physical and emotional health, intelligence, a strong sense of ethical and professional responsibility, and the ability to think critically.
Related Resource: 20 Best Online Schools for Criminology 2017
What Are the Common Steps for Becoming a Police Officer?
Community leaders charged with hiring the best candidates to serve the public in the local police force develop a hiring process to reflect their community's needs. The standard process that these leaders put in place allows them to learn more about the candidate and his or her abilities to capably perform the duties of the position:
1. The Application. Like any job, the application lets the hiring staff learn the basics about the police candidate, such as level of education, past work experience, and names of character references. The application allows the candidate to introduce themselves and basically express their interest in the job. Police officer hopefuls can apply online, or they might visit their local police headquarters to fill out an application or to take one home.
2. The Basic Abilities Test. At this point in the hiring process, a criminology degree might prove most helpful, but it is not essential to do well on the basic abilities test. Many police officers do not hold a degree from college and perform just fine. However, a higher score achieved through additional education might alert officials to a candidate with future potential as a detective or a leadership position. The test measures the candidate's critical thinking skills, problem-solving skills, reading comprehension, and cognitive reasoning abilities.
3. The Physical Assessment. The nature of police work makes it critical that police officers maintain good physical fitness. Job candidates may need to perform a running test, an obstacle course, and other physical ability tests.
While those pursuing a career as a police officer can certainly benefit from attending college to earn a degree in criminology, it is not a requirement. It is only mandatory that police officer candidates hold a high school diploma or a GED equivalent.
There are a few core reasons a degree might work in the job candidate's favor, such as:
Competitive Advantage. If there are limited spots available for new police officers,a candidate who holds a college degree might have an advantage over another candidate who has not attended college in a related discipline.
Promotion Potential. In order to move up in the ranks to the level of detective and higher, police officers who only hold a high school diploma need to take college courses to get the necessary credits, making a degree a definite advantage.
Most of all, if a degree helps a police academy candidate feel more confident in their attempt to become a police officer, that on its own makes a degree in criminology invaluable.