On a small island in Holland, a modern day "Macbeth" unfolds as a beloved leader is overthrown and a utopian community is rocked by bloodshed and greed. Hominid is based on actual events within a chimpanzee colony in a Holland zoo as documented by world-renowned primatologist Frans de Waal. Created in collaboration with Out of Hand Theater Company.
Productions: Theatre Emory/Out of Hand Theater Company (outofhandtheater.com), Oerol Festival, Netherlands (The Lunatics), Detmold Theater Festival, Germany (The Lunatics).


To book in for a holiday program call the Wollangarra flat on 51480492 to book your place. Print and fill out two copies of the Under 18 medical form. Post them up to us at 'Wollangarra, Licola 3858'. It is vital that the medical forms are filled in at least one week before the program, so we can prepare for different dietary requirements and make any necessary enquiries regarding medical issues. You will receive a letter in the mail with more information, train times etc. School groups please see the 'Schools' page for booking information and forms.


As a planner, I understand how difficult it is when you start to feel your plan falling apart. When I entered freshman year as a Computer Science major, I was certain that this was what I wanted to do. I told everyone who would listen all about my big plans to forge a path for women in the tech industry and how I would make a name for myself in the fields of programming. My family was so proud that I had received a full scholarship to an out-of-state school to study an emerging field and I was so confident that I would burst through the stereotype of women in engineering.
When I pledged my sorority, I was the only Computer Science major out of 150 girls (yes, my pledge class was that big!) and everyone commented on "how smart I must be" to pursue the degree. I only used this as more motivation and I was determined. I had a plan that I shared with everyone and I wasn't going to let anything stop me. But when Fall came around my freshman year and I didn't understand any of the material, it was hard to adjust my expectations.
So far, I had breezed through high school AP courses and never really had to study. These intro courses to programming, however, left me high and dry on knowledge and it was like I was on a whole new planet. I spent hours and hours in the library researching and watching tutorial videos but nothing was registering. I barely scraped by in my programming classes and when final grades came around, I realized my plan was falling apart.
Midway through my second semester, I finally admitted to myself that I was not cut out for the field and, to be honest, I didn't really enjoy it. Looking back I realized I picked Computer Science as a major not because I was genuinely interested in the field, but more so I could boast that I was studying a prestigious area of academia and it made me feel important and intelligent. I broke down mid semester and called my parents in the middle of the night and admitted that I had been struggling. I thought they would be mad and disappointed, but the only thing they were concerned with is what would make me happy. Looking back, the fears I had of disappointing my family were unfounded and silly. The next day I transferred out of the engineering school and declared a major in Human Development. I intend to go onto nursing school when I graduate this upcoming December and work in pediatric nursing once I graduate. My original plan is so far different from my plan now that I can't even compare the two.
So, is your plan falling apart? Here are some tips to remember if you find your plan is not working out.
You're going to figure it out. I know it doesn't seem like it, but when one door closes, two more open (you just can't see them yet). And trust me, it's okay to not know what to do next.
One of the worst feelings is your plan falling apart and having no one to talk to about it. Pick a close friend, your roommate, or even an online chat board. Talking about it to someone will help you gather your thoughts on how to proceed and may even spark some ideas on what to do next.
I know that you're probably afraid of disappointing them but I promise they just want what's best for you. Admit to any wrongdoings and be factual in your statements. If you're honest with them they will be more open and understanding.
You're setting yourself up to fail if you think you're not going to have to readjust your plans. Give yourself some leeway and try to tell yourself that this is just a speed bump in the middle of a long road and everyone hits one from time to time.
Don't give up! Just because you didn't get into grad school this time doesn't mean you won't get in next semester. Keep in mind your long-term goal and while you might have to take a roundabout path, you'll figure out a way to get there eventually.
Maddison is a University of Alabama student from St. Louis, MO. Maddison loves all things macaroni and cheese, Grey's Anatomy, The Blacklist, napping, and sugar-free popsicles. You can follow her Instagram @maddisonnm where she mostly posts pictures of her Canadian cat and boyfriend or follow along on her new blog.


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Action – pierwszy minialbum południowokoreańskiej grupy NU'EST, wydany 11 lipca 2012 roku przez Pledis Entertainment. Płytę promował główny singel o tym samym tytule. Album sprzedał się w liczbie  egzemplarzy (stan na wrzesień 2017 roku).

Lista utworów

Notowania

Przypisy

Linki zewnętrzne
 Teledysk do Action w serwisie YouTube

Albumy k-pop
Minialbumy wydane w roku 2012

redpajama_set_name: RedPajamaWikipedia


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Save Cover Preview for Konrad Wachsmann and the Grapevine Structure
Distributed for Park Books
Konrad Wachsmann and the Grapevine Structure
Edited by Marianne Burkhalter and Christian Sumi
With Contributions by Fabio Gramazio, Matthias Kohler, Hannes Mayer, Andreas Burkhalter, and Marco Pogacnik
Buy this book: Konrad Wachsmann and the Grapevine Structure
Request an exam Copy for Konrad Wachsmann and the Grapevine Structure
Find this book in a library: Konrad Wachsmann and the Grapevine Structure
German modernist architect Konrad Wachsmann (1901–1980) had a career-spanning interest in construction processes—in particular the prefabrication of building components and their assembly within modular systems. In this respect, Wachsmann was a pioneer whose ideas and work paved the way for today's industrialized construction. Many contemporary masters, such as Renzo Piano and Richard Rogers, have taken inspiration from and paid homage to Wachsmann's forward-thinking work.
With Konrad Wachsmann and the Grapevine Structure, Swiss architect Christian Sumi synthesizes years of careful research into a compelling look at the career and lifetime contributions of this highly creative architect. At the core of the book is Wachsmann's dynamic Grapevine Structure of 1953, a universal construction element developed with students during his tenure at the Chicago Institute of Design—part of what is today the Illinois Institute of Technology. The book also investigates Wachsmann's Packaged House System, his furniture designs, his relocatable hangars for the US Air Force, and, in particular, the Local Orientation Manipulator (LOM), an apparatus for the automated assembly of building components developed in 1969 with John Bollinger and Xavier Mendoza at the University of Southern California, Los Angeles. Fabio Gramazio, Matthias Kohler, and Hannes Mayer of Gramazio Kohler Research revisit the LOM from a contemporary perspective where robotic fabrication processes have become increasingly common. The book also features an essay by Andreas Burkhalter on Wachsmann's legendary knotted joints in the context of possible similar structures in the human brain and by Marko Pogacnik on the significance of Wachsmann's lectures at the Salzburg Summer Academy in the late 1950s.
Published to coincide with an exhibition on Konrad Wachsmann at the Sixteenth International Architecture Exhibition of the Venice Biennale, the book features rich illustrative material, including many plans and photographs that are published here for the first time.
Read Moreabout Konrad Wachsmann and the Grapevine Structure Read Lessabout Konrad Wachsmann and the Grapevine Structure
136 pages | 100 color plates, 60 halftones | 9 x 12 1/2 | © 2018
View all books from Park Books

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Evolve sets a new standard in style, quality, spacious and secure living, perfect for those starting the next stage of their life or as an attractive investment opportunity. Location is paramount and Chermside is in the thick of the action. 9km from the CBD, 7km from the Airport and linked to major arterial roads.
Located within walking distance to Westfield Chermside (Queensland's largest shopping centre), lifestyle awaits with entertainment, cafes, shopping and convenience. Apartments are modern, spacious and superbly designed, providing a true sense of style and living.


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Q: animation with delay android in ImageView I'm trying to implement animation with delay in android, but in my case the imageview is infinitely rotating, because i don't know how can i dynamically stop and start it.
final RotateAnimation anim = new RotateAnimation(0f, 350f, 15f, 15f);
        anim.setInterpolator(new LinearInterpolator());
        anim.setRepeatCount(Animation.INFINITE);
        anim.setDuration(700);
        imageView.startAnimation(anim);

A: Take a look at setRepeatCount arguments and setStartOffset method. First one allows you to limit repeated animation, second one - introduce a time delay.

redpajama_set_name: RedPajamaStackExchange


Want to join the Manhattan Beach Dolphins Swim Team?
All interested swimmers must enroll in the Pre-Swim Team class to be given an opportunity to join the Manhattan Beach Dolphins. Swimmers must be able to swim 50 yards freestyle and 50 yards backstroke without stopping. This class is designed to work on endurance, stroke technique and most importantly to prepare swimmers for the Manhattan Beach Dolphins Swim Team.
The swim team coaches will organize and prioritize the swimmers according to stroke proficiency and participation and, according to the available spots on the team, will make the determination of who will move on to the team and who should continue with Pre-Swim Team class. It is our goal to include every child who has a wish to participate.
New swim team enrollment is dependent upon the number of returning swim team members. Therefore, the available spots will vary for each season and each age group.
Swimmers interested in the swim team must be enrolled in the Pre-Swim Team class to be considered for the Manhattan Beach Dolphins Swim Team.
The Pre-Swim Team class is offered four times a year (Summer, Fall, Winter, and Spring). This class is designed to work on endurance, stroke technique, and most importantly, to prepare swimmers for the Manhattan Beach Dolphins Swim Team. Enrollment in Pre-Swim Team does not guarantee a spot on the Dolphins Swim Team. Once the class fills-up, a waitlist will be generated and used throughout the year for the other pre-swim team classes.
Please Note: For Fall 2018, Winter 2019, and Spring 2019 we are only taking participants off the waitlist that was generated during Summer 2018. The waitlist that was generated during Summer 2018 will be active until May 1, 2019 at which point, any participant who was not called or placed into the Pre-Swim Team, must re-register along with new participants.
2019 Pre-Swim Team registration will begin Monday, May 6, 2019 for Manhattan Beach residents and Tuesday, May 28, 2019 for Non-Manhattan Beach residents. This will also be the time that new participants can register for the Pre-Swim Team.
For more information, please contact Jasper Nery, Aquatics Coordinator, (310) 802-5428.


Epsom salt is considered to be one of the most multi-functional and beneficial products on the market. Its name comes from the place where it was found, Epsom England, a small district of Sydney. Epsom salt has been appreciated for its benefits both in general health and beauty care for many years.
There are many benefits of Epsom salts including detoxifying the body and protecting body against bacteria causing breakouts; reducing redness, swelling, pain, and inflammation resulted from acne by its anti-inflammation properties; removing dirt, dead skin cells, and other impurities causing acne; absorbing excess oil and dehydrating bacteria that may grow in clogged pores and then cause acne… And we can find that all of these benefits are applied to skin problems, especially acne one.
There are a variety of commercial acne treatments but they may be expensive and often come with unexpected side effects. If you are finding a natural, effective and affordable remedy for your acne problem, Epsom salt is actually a relevant one.
In this article, VKool.com will show you 12 useful ways on how to use Epsom salt for acne treatment without any side effect. This article listed the best methods and tips for with some other natural ingredients to treat acne with Epsom salt effectively at home from reliable sources. However, it is not intended to give medical advice and it is solely for the informational purpose. Keep reading this article to learn these useful ways to use Epsom salt for acne treatment quickly and effectively.
Add 2 teaspoons of Epsom salt to 1 cup of water.
Apply this water to your skin by a cotton ball and keep it for few minutes.
Wash your face off with cool water, and then pat it till dry.
You can use olive oil combining with Epsom salt for acne treatment.
Mix adequate quantities of Epsom salt with extra virgin olive oil.
Apply the mixture to your face and massage it in circular motions.
Keep your face for few minutes before rinsing it off with warm water.
Make a mixture of 2 tbsp Epsom salt, 1 cup of water, and 1 cup of organic rolled oats.
Apply the mixture to your face after wetting it with water and massage it gently with circular motions.
Keep it for 5 minutes, and then rinse it with warm water.
Do this 3 times a week to balance and exfoliate your skin's pH level.
Stir 3 tbsp Epsom salt with 2 teaspoons organic coconut oil that is melted over low heat.
Once Epsom dissolves, remove the mixture from heat and let it cool to normal temperature.
Apply it to your skin and massage it gently with circular motions in about 5 minutes.
Rinse your skin off with warm water and let it dry.
Do this 3 times per week to get a better result.
Note:It is advised to add tea tree oil to the mixture for added benefits.
Using milk and Epsom salt for acne treatment is a remedy applied to those who have oily skin.
Make a mixture of ½ teaspoon of Epsom salt, ¼ cup of non-fat milk, 1 raw egg, and the juice of 1 fresh lemon.
Apply the mixture to your skin after making it wet with water.
Leave the mixture on your face till it dries, and then rinse off with water.
This process uses Epsom salt for acne appearing on back and chest. Plus, it gets rid of the dead skin cells causing dry, flakey, and irritated skin.
Wash your face and neck with fresh water and pat dry.
Mix ½ tbsp of Epsom salt and ½ tbsp of facial cleanser.
Apply the mixture to the acne affected skin and massage gently with circular motions in 2 minutes.
Rinse your applied area with cool water.
Add oil-free moisturizer to your skin after drying it.
Do this remedy twice weekly.
Note:Don't rub harshly because it causes inflammation and irritation along with the development of your present problem to other skin parts.
This combination is one of the ways using Epsom salt for acne treatment.
Make a mixture of ½ tbsp Epsom salt, 1 tbsp fresh lime fruit, 1 tbsp of powdered milk, and 1 tbsp cognac.
Apply the mixture to the acne affected area and keep it until dry.
Rinse your skin off with cold water and let it dry.
Add oil-free moisturizer as usual.
Do this every day to clear the acne effectively.
Olive oil, honey and lemon are also combined with Epsom salt for acne treatment.
Make a mixture of 1 tbsp each of Epsom salt, raw honey, and olive oil.
Add 1 teaspoon of lemon juice into the mixture and stir it.
Massage the mixture gently on your face skin with circular motions.
Keep your face about 15 minutes.
Wash it off with warm water and let it dry.
Add oil free moisturizer to your face as usual.
Carrots and mayonnaise are mixed with Epsom salt for acne treatment and this remedy is used to treat acne in those who have dry skin.
Mix ½ tsp of Epsom salt, ¼ cup of grated carrot, and 1 ½ tsp of mayonnaise, and then blend them together till they get smooth.
Apply the mixture to your skin after wetting it, and massage it in circular motions.
Keep your face for 5 minutes before rinsing it off with water.
Add oil- free moisturizer as usual.
This is a common way to use Epsom salt for acne treatment.
Add 2 cups of Epsom salt into warm water in the bathtub.
Get in the bathtub and soak about 15 – 20 minutes.
Rinse your body with plain water under a shower.
Use this remedy 3 times a week to treat chest acne and cystic back.
Add other ingredients into the bathtub including a half tbsp of sea salt with a half tbsp of coconut, olive, or jojoba oil.
Learn more: 14 days acne cure review – is Casey Gentles' book useful?
This process unclogs pores as well as relieves inflammation.
Mix 2 tbsp of Epsom salt and 1 cup of lukewarm water.
Soak a fresh cloth in this mixture and wring out the water.
Cover your skin with the cloth and keep it until cool.
Repeat 3 times soaking, wringing out, and placing the cloth on your skin.
Rinse your face off with water and pat dry.
Do this 3 times per week.
Make a mixture of 1 tbsp of Epsom salt and 1 tbsp of your preferred dried herbs.
Add ½ tbsp of natural oil like extra virgin olive oil into the mixture and stir together.
Apply the mixture to your skin and cover it with a clean cloth that is soaked in warm water.
Keep your face for 15 minutes.
Take the cloth out and rinse your face with water.
Do this 3 times a week to remove acne effectively.
Because Epsom salt is not a drug, so it is unavoidable to have side effects. Therefore, you should follow some tips below to get the best results as well as avoid the unexpected side effects.
Firstly, Epsom salt is a salt, so it can be extremely painful when coming into contact with an open wound.
Secondly, Epsom salt is still a very abrasive agent on its own. It is advised to be mixed with a cleanser, water, or anything else that does with Epsom salt so as to decrease the risk of aggravating your skin. That using Epsom salt by rubbing it on the skin directly is able to absolutely increase acne production.
Thirdly, Epsom salt is used for topical/skin but not for ingesting. Of course, there are other types of this salt produced for ingestion, but remember to take it in according to the doctor.
Finally, Epsom salt can interact with several drugs, so remember to consult your doctor before when you are taking any medications interacting with magnesium or magnesium sulfate.
To get more information related to health problems, go to our main Beauty page. After studying the writing of top 12 ways on how to use Epsom salt for acne treatment, hope that this article will help you learn more some easy and simple ways to get rid of acne with Epsom salt by yourselves. All these remedies are safe, natural, cost effective as well as easily available for your health. But you should not forget to try these remedies only after carrying out a small test in order to check your body reaction, and then continue using them. If you have any question or comment, please leave them below, I will respond you as soon as possible. Also, you can share your experiences with us if you know other ways on how to use Epsom salt for acne treatment.
List of top foods that cause acne breakouts – 24 worst foods!


Believe it or not, the latest viral video, that was just posted 2 days ago, now has over 5 million views, and it's about roads and solar panels….seriously.
The two brilliant minds behind the latest technology called 'Solar Roadways' published a video in the beginning of this month that detailed their world-changing project – but the video was fairly boring.
That prompted viral video creator Scott Brusaw, to step in and help get the word out.
"Solar FREAKIN' Roadways!" is filled with passionate excitement and specifically targets young adult minds and cooler older adult minds while staying true to the facts and vision.
Here's the Indiegogo account you might want to check out if you love the concept.


Famous gardener Margery Fish was once asked for the secret of gardening, she answered 'the secret is, when in doubt plant a Geranium! and we agree. Geraniums are so easy to grow, happy in borders and containers, amazingly floriferous throughout the summer, great groundcover, slug and rabbit resistant, drought tolerant, attractive to bees and not fussy on soil conditions in sun or part shade. Fully hardy perennials.
Geranium x magnificum Rosemoor (Blue Pink Purple).
Geranium maculatum Beth Chatto (Pink).
Geranium pratense Splish Splash (White Purple Lilac).


This is a placeholder page for Nancy Eyre, which means this person is not currently on this site. We do suggest using the tools below to find Nancy Eyre.
You are visiting the placeholder page for Nancy Eyre. This page is here because someone used our placeholder utility to look for Nancy Eyre. We created this page automatically in hopes Nancy Eyre would find it. If you are not Nancy Eyre, but are an alumni of Dow High School, register on this site for free now.


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Day 1 results from Vets Jamboree at Frilford Heath...
KEMNAY WIN THE LYON INTER CLUB DOUBLE FOURSOMES
Charlotte and Kate fly the English flag
Lottie Woad wins England's 'most improved' title
R&A AMATEUR CHAMPIONSHIPS RESUME WITH BOYS, GIRLS,...
Solheim Cup captains put faith in youth as teams f...
In-Kyung Kim of South Korea wins the Ricoh Women's...
MILNGAVIE PLAYER - LORNA MCCLYMONT WINS ST ANDREW...
Follow the Ricoh Women's British Open live
In-Kyung Kim writes history with lowest total afte...
CREAMER TO REPLACE KORDA ON USA SOLHEIM CUP TEAM
USA Solheim Cup Captain Juli Inkster announced today that six-time USA Solheim Cup veteran Paula Creamer will replace the injured Jessica Korda at the 2017 Solheim Cup, being conducted next week in West Des Moines, Iowa.
Inkster chose Creamer as her alternate when she selected her team on Sunday night and informed the European team as required by the captain's agreement. However, she did not publicly reveal her choice until after Korda withdrew on Monday due to a forearm injury.
"The reason why I put Paula in the hat was she'd be there," said Inkster on a conference call just moments ago. "She knows what's going on. She has the experience. She's playing well."
Korda had been battling the injury for several weeks and withdrew from the Ricoh Women's British Open after the first round last Thursday to seek treatment. She finished fifth in the USA points list to earn an automatic spot on the 12-person team.
"Sadly the injury to my forearm is not going to heal in time for the Solheim Cup," Korda wrote in a social media post on Monday. "I cannot put the team at risk of me not being 100 percent so unfortunately I have had to make the difficult decision of relinquishing my spot on the team."
This will be Creamer's seventh Solheim Cup appearance. She has a 14-8-5 playing record, and her 16.5 points are more than any American player in Solheim Cup history except Inkster (18.5 in nine appearances), fellow 2017 teammate Cristie Kerr (17 in eight appearances) and Meg Mallon (16.5 in eight appearances).
"I'm very honored. I'm ready to wear red, white and blue for the seventh time," said Creamer. "It's pretty crazy and I'm excited, but it's sad under these circumstances."
Inkster has selected a second alternate and informed the European team, as done with the initial team selection.
The 2017 Solheim Cup will be held Aug. 8-10 at Des Moines Golf & Country Club in West Des Moines, Iowa.
Labels: SOLHEIM CUP
posted by Gillian | See story on its own page | 9:09:00 am


TIPP10 is a free touch typing tutor for Windows.
EditByBSEditor: TIPP10 is a free touch typing tutor for Windows, Mac OS and Linux. The ingenious thing about the software is its intelligence feature. Characters that are mistyped are repeated more frequently. Beginners will find their way around right away so they can start practicing without a hitch.
The lesson Texts ReAct instantly to your typing mistakes by repeating mistyped letters more frequently. The system helps you eliminate typing mistakes and learn touch typing efficiently. A wide range of dictations ensures you'll never get bored. You will become acquainted with all the keys on the keyboard in 20 sequential practice lessons. Commonly used characters are practiced earlier and more frequently than those that appear less frequently.
You can change the font, speed and color of the text in the ticker to ensure a steady typing flow. Keys and key paths appearing in color on a virtual keyboard help you to use the right fingers and keep the right starting position. A status bar displays the fingers that should be used and tallies errors and characters per minute. you can free download TIPP10 Portable 2.1.0 now.
Please be aware that Brothersoft do not supply any crack, patches, serial numbers or keygen for TIPP10 Portable,and please consult directly with program authors for any problem with TIPP10 Portable.


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Innovation and Growth Minister Pulev: In the First Six Months of 2023, BGN 1 Bln Will Be Provided for Businesses
Caretaker Prime Minister of Innovation and Growth Alexander Pulev said on NOVA Saturday: "We are starting to rapidly open measures under the structural funds at the Ministry of Innovation and Growth. For the first six months of this year alone, we will provide one billion BGN for seven procedures."
The caretaker cabinet found zero approved EU programmes for zero leva. Five months later, there are ten out of ten approved programmes with an assured resource of BGN 20 billion for the Bulgarian economy, commented Pulev.
The Minister also pointed out that there was one open procedure under the Recovery and Resilience Plan, but with only four submitted project proposals. "The plan was open and working, but no one knew. So my team and I made a mobile reception that went around all the districts in the state. We held 28 meetings with all regional governors and representatives of local businesses. As a result, we have submitted more than 10,200 project proposals under two open and already completed procedures from the Plan," said Pulev. He predicted that interest will continue to grow.
Under the first procedure, "Technological modernization", a total of 953 projects will receive funding of BGN 260 million, the Minister said.
When asked if it is certain that the business will receive financing in view of MPs requesting a renegotiation of the Recovery and Resilience Plan, Pulev assured that there are enough funds.. "The first payment of funds under the Plan in the amount of three billion BGN is provided by the Cabinet, there is also national co-financing. According to all procedures, there will be money," said Pulev.
The Minister also announced that at the beginning of February, the third procedure under the Recovery and Resilience Plan for renewable energy sources and batteries for local energy storage, worth BGN 200 million, will be open for applications.
One of the first procedures which will open in April, will be for the implementation of innovations, for a total of BGN 293 million.
Pulev added that both European programmes under his Ministry, the "Competitiveness and Innovations in Enterprises" and the "Research, Innovation and Digitization for Smart Transformation" programmes were approved in record time.
Regarding Minister Pulev's second official visit to Saudi Arabia, he said that he met with the executive directors of the country's largest sovereign wealth fund, which manages over half a trillion dollars, as well as with the ministers of communications, economy and energy. "We've come back with a framework agreement that will define the entire investment regime between Bulgaria and Saudi Arabia," said Pulev. During his first visit together with Deputy Prime Minister Hristo Alexiev, direct flights Sofia-Riyadh were arranged.


Securities offered through Securities America, Inc. Member FINRA/SIPC. Advisory services offered through Securities America Advisors. Matthew Taggart, Representative. Taggart Investments is not affiliated with the Securities America companies.
This website is neither an offer to buy nor a solicitation to sell securities or insurance.


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16,000 people diagnosed with a brain tumour every year
Brain Tumour Research Scientific and Medical Advisory Board (SMAB)
Our Scientific and Medical Advisory Board (SMAB) provides independent, objective reviews of our research programme and strategy.
Members of the SMAB are chosen due to their internationally regarded experience and expertise, enabling them to provide invaluable scientific support and advice to the charity, our researchers and our Board of Trustees. Members of the SMAB include independent researchers who are not beneficiaries for a particular application round. Any conflicts of interest must be declared and are taken into consideration during every stage of each review process. Our Conflicts of Interest and Confidentiality Policy is available from here.
SMAB members are volunteers and do not receive any payment for their services, however reasonable expenses for travel and accommodation are provided. They are appointed as individuals to fulfil the role of the committee, not as representatives of their particular profession, employer or interest group. We are very grateful for their generous donation of time and expertise.
Our SMAB helps to ensure that we are investing in high quality, peer-reviewed research that serves the best interest of patients and scientists and clinicians, provides the very best basis for effective clinical trials and eventually new therapies that will bring us closer to a cure for brain tumours.
This process of peer review is internationally recognised as best practice for ensuring that our funds are used wisely and effectively. We are a member of the Association of Medical Research Charities and a partner organisation of the National Cancer Research Institute.
Brain Tumour Research Annual Review Process
Every year, Centres are asked to complete a report designed to answer important questions.
Are supporters' donations being used in the most effective way possible, to bring us closer to a cure?
Does the research offer good value for money?
Are the Centres progressing according to plan?
Does their research remain relevant and valuable in the light of any new discoveries from around the globe?
Does the research complement and not duplicate other research?
Has the grantholder achieved meaningful outputs, outcomes and achievements from the research programme that are reasonable for the level of grant funding and within a single year time frame?
Is the Centre securing a good level of grant from other funders?
Are key performance indicators set the previous year being achieved?
Is the Centre producing an appropriate number of papers, and are they being published in high quality, peer reviewed publications with a high impact factor?
Are those publications providing a relevant and valuable contribution to the UK and Global neuro-oncology knowledge base?
Is there evidence of good levels of collaboration and interactions with other research groups in order to maximise the investment in the centre by Brain Tumour Research?
Their completed reports are then sent out to selected members of the SMAB, who review them using both qualitative and quantitative methods: in other words, they offer comments, and scores on a scale of 1 to 5, in each category.
Each Centre is visited by a team from Brain Tumour Research so that the reports can be discussed in person. The team consists of the Chair of the SMAB, Sue Farrington Smith MBE (Chief Executive), the Director of Finance and Operations and the Director of Research, Policy and Innovation. This enables any questions arising from the reports to be clarified and fed back to the Research Sub-Committee alongside the SMAB reviews. During the COVID-19 pandemic, to ensure that Annual Review meetings could be conducted safely, we held them by video-conference.
Reports from the Annual Review meeting are submitted to the Research Sub-Committee, which is comprised of Brain Tumour Research Trustees. The Research Sub-Committee also independently review the full reports from each Centre, before making their recommendations for the next year of grant funding to the full Board of Trustees.
This entire process is designed to assist the charity in the prioritisation of where funds should be granted, especially if Centre requirements are in excess of charity funds available
Brain Tumour Research Quinquennial Review (QQR) Process
Every five years, each Centre of Excellence is asked to complete a more in-depth version of the Annual Review Process.
Their report is sent out to International Peer Review, to a panel consisting of reviewers with a specific area of expertise related to the focus of the Centre, as well as members of the SMAB who also have relevant areas of expertise.
Members of the International Peer Review Board accompany the Brain Tumour Research lead team on a visit to the Centre under review.
The review is an important stage for the charity to review the Centre's progress over the previous five years and consider its future plans for the next five years. This provides the charity with an independent, expert assessment of the Centre's achievements and goals. It also provides an opportunity for the Centre to include new areas of research that have been indicated as potential routes to a cure for brain tumours, based on their discoveries in the preceding five years.
Other roles of the SMAB
In addition to the above, the SMAB may sometimes be required to complete other tasks.
Assist the charity's Board of Trustees in monitoring the research strategy and assessing effectiveness and impact of the charity's research spend
Assist the charity in exploring opportunities for leverage of research funds and for developing research partnerships
Advise the charity's Board of Trustees on the overall strategy for research and the identification of opportunities and gaps
Advise the charity's Board of Trustees on the best mechanisms to achieve the research objectives
Recommend international peer reviewers for the applications, based on the reviewers' knowledge of established Centres
Meet with members of the Brain Tumour Research Sub-Committee to prioritise selection of centres based on feedback received from the International Peer Reviewers
Provide one or two members to accompany charity Research Sub-Committee members on initial site visits prior to engagement of new Centres
Provide ongoing advice to the Brain Tumour Research team and 'expert' quotes and support with raising awareness through the media and with politicians
Provide members to conduct Quinquennial Review site visits
Our SMAB Members plus other QQR Peer Reviewers
Chair - Prof Garth Cruickshank
SMAB and Peer Reviewer
Prof Cruickshank retired as Professor of Neurosurgery at the Institute of Cancer and Genomic Sciences, Birmingham in 2018. He worked with the NCRI and European Association of Neuro-oncology (EANO), developing services for brain tumour patients as well as several clinical trials, most recently the new Immunotherapy vaccine trial 'STING'.
With a degree in biochemistry and physiology, then a PhD in Pharmacology, he began his oncology and neurosurgical career at the Royal Free Hospital School of Medicine in London, moving on to undergo Specialist Training in Neurosurgery in Glasgow's prestigious Institute of Neurological Sciences.
Here he carried out the first Polarographic Oxygen measurements in Human Brain tumours during surgery, followed by other work related to our understanding of hypoxia in brain cancer. Data from these studies lead to the trial of Tirapazamine as a hypoxic sensitiser for radiotherapy. In 1993 as a Senior Lecturer in Neurosurgery he worked with Prof Moira Brown FRSE on the use of Oncolytic Herpesvirus HSV1716 directly injected into human GBM for the first time.
In 1997 Prof Cruickshank moved to the Chair of Neurosurgery in Birmingham. He worked with the NCRI and European Association of Neuro-oncology (EANO), developing services for brain tumour patients as well as several clinical trials, most recently Avoglio, Oparatic, IDEB and the new Immunotherapy vaccine trial 'STING'. In Birmingham he helped to introduce new innovations such as loco-regional drug implantation and worked on novel treatments such as biologically targeted radiation therapy. He has also been working closely with basic scientists on new therapeutic approaches in target discovery and drug delivery, as well as carrying out progressive surgery for brain and skull based tumours.
In 2006 he was on the team that introduced the NICE Brain and CNS tumours Improving Outcomes Guidance that transformed the landscape for the delivery of Neuro-Oncology in the UK. He has served on editorial boards and the council of BNOG, BASO and the NCRI Clinical Studies Group. For many years he was deeply involved in the commissioning of cancer services and continues on the Cancer Services Committee of the RCS as SBNS representative. Currently he chairs the DVLA Neurology Medical Panel and is also the lead Clinician on the NICE 'Primary Brain Tumours and Cerebral Metastases' clinical guidelines development program due to publish in late 2018. When not working he sails, writes, enjoys Scottish country dancing and cherishes his wife and children (and now first grandchild).
Dr Khalid Shah
Vice Chair of Research, Department of Neurosurgery
Director, Center for Stem Cell and Translational Immunotherapy
Director, Center for Excellence in Biomedicine
Brigham and Women's Hospital, Boston, US
Principal Faculty, Harvard Stem Cell Institute
Dr. Khalid Shah is the Vice Chair of Research for the Department of Neurosurgery at BWH and a Professor at Harvard Medical School. He directs The Center for Stem and Translational Immunotherapy and also a joint Center of Excellence in Biomedicine. He is also the Principal Faculty at Harvard Stem Cell Institute in Boston.
Dr. Khalid Shah and his team have pioneered major developments in the Stem Cell therapy field, successfully developing experimental models to understand basic cancer biology and therapeutic stem cells for cancer.
These studies have been published in a number of very high impact journals like Nature Neuroscience, PNAS, Nature Reviews Cancer, JNCI, Stem Cells and Lancet Oncology. Dr. Khalid Shah's stem cell work has caught the attention in the public domain and as such it has been highlighted in the media world-wide including features on BBC and CNN. Recently, Dr. Khalid Shah's laboratory has reverse engineered cancer cells using CRISPR/Cas9 technology and utilized them as therapeutics to treat cancer. This work was published in journal Science Translation Medicine and highlighted world-wide including features on Scientific American, New York Times and NPR. Amongst Dr. Khalid Shah's published works are two books featuring groundbreaking insights into stem cell therapies for cancer, Stem Cell Therapeutics for Cancer (Wiley-Blackwell), and Mesenchymal Stem Cells in Cancer Therapy (Elsevier).
The potential of developing novel cancer therapies by him and his team has been recognized by many cancer alliances and associations. Based on this, he has received the young investigator award from Alliance for cancer gene therapy (ACGT), Research fellow award from American Cancer Society (ACS), Distinguished research award from Academy of Radiology and Innovation awards from James McDonnell Foundation, American Brain Tumor Association (ABTA) and Goldhirsh foundation. Recently he has received Department of Defense Idea and Impact awards for his work on treating metastatic brain tumors. Dr. Shah has often been invited to serve as a grant reviewer for the NIH and has reviewed applications to granting agencies in the US, Australia, and United Kingdom, such as the European Science Foundation, the Wellcome Trust, and the California Institute of Regenerative Medicine. Additionally, Dr. Khalid Shah has participated in the training of numerous undergraduate, graduate students and residents who have come from across the US and from 40 foreign countries. He has also received many awards for his mentorship including Young Mentor Award from Harvard University
Dr. Khalid Shah holds current positions on numerous councils, advisory and editorial boards in the fields of Cell therapy and Oncology. He has presented his findings for more than 300 academic seminars worldwide and in recent years has given various keynote lectures on Innovation and Translation of biological therapies. Dr. Khalid Shah currently holds more than 10 patents and he has founded two biotech companies whose main objective is the clinical translation of therapeutic cells in cancer patients.
Prof Dr Paolo Salomoni
Nuclear Function Group
German Center for Neurodegenerative Diseases (DZNE)
within the Helmholtz Association, University of Bonn
University College London, UK
Prof Salomini's professional career has spanned both the UK and US. His work comprises experimental models, patient-derived material and state-of-the art (epi)genomics, the latter supported by a strong bioinformatics/computational biology core.
Prof Salomoni has been Senior Group Leader at DZNE Bonn since 2017.
He started his PhD training at the Kimmel Cancer Center, Philadelphia, under the supervision of Bruno Calabretta. In 1999 he moved to the Memorial Sloan-Kettering Cancer Center, New York, in the laboratory led by Pier Paolo Pandolfi.
After finishing his postdoctoral training at MSKCC in 2003, he moved to the Medical Research Council Unit in Leicester, where he was Programme Leader Track and then Programme Leader. Subsequently, he joined the UCL Cancer Institute as Lead of the Samantha Dickson Brain Cancer Unit and became UCL Professor of Nervous System Tumour Research.
Paolo Salomoni was a member of the British Neuro-Oncology Society (BNOS) Council until 2017.
The main focus of his group is on dissecting the relationship between interchromatin space, chromatin and transcription, and how alterations of the underlying molecular mechanisms contributes to human disease, from cancer to neurodegenerative conditions. This work carries multiple implications ranging from understanding disease etiology to the identification of druggable targets. His studies comprise experimental models, patient-derived material and state-of-the art (epi)genomics, the latter supported by a strong bioinformatics/computational biology core.
Dr Sean Lawler
Assistant Professor, Harvard Medical School
Managing Director, Harvey Cushing Neurooncology Laboratories
Department of Neurosurgery, Brigham and Women's Hospital
Building for Transformative Medicine, Boston, US
Dr Lawler is a molecular biologist, having worked in both the UK and US. His lab has been investigating preclinical studies on the blood-brain barrier in glioblastoma, oncolytic virus-based immunotherapeutic strategies, as well as the role of cytomegalovirus in the promotion of tumour growth.
Dr Lawler has been working on brain tumors for the last 15 years, including at Univesity of Leeds before his move to the US in 2013.
His lab focuses on understanding the biology of glioblastoma and the development of improved therapeutic strategies.
Originally specialised in cell signaling mechanisms, his group has studied the effects of a variety of small molecule kinase inhibitors on glioblastoma cell proliferation and migration. He was one of the first investigators to characterise microRNAs in glioblastoma.
Dr Lawler is now Managing Director of the Harvey Cushing Neuro-oncology Laboratories in the Department of Neurosurgery at Brigham and Women's Hospital, where his lab has been investigating preclinical studies on the blood brain barrier in glioblastoma, oncolytic virus-based immunotherapeutic strategies, as well as the role of cytomegalovirus in the promotion of tumour growth.
Dr Neil Kad
Dr Kad is the Patient Representative on our Scientific and Medical Advisory Board, having lost his sister to a brain tumour in 2015. He is a Senior Lecturer at the University of Kent where he is studying DNA repair mechanisms at the molecular level.
Dr Kad received his BSc (Hons) Biochemistry from the University of Sheffield, and his PhD in Biochemistry from the University of Bristol under the supervision of the late Prof AR Clarke.
He then undertook a postdoctoral position studying the molecular mechanisms of dialysis related amyloidosis at the University of Leeds with Prof SE Radford FRS before spending six years at the University of Vermont, USA. Here, he studied molecular motors and developed an interest in DNA repair.
Returning to the UK Dr Kad embarked on the study of DNA repair using novel single molecule methods during his first Lectureship at the University of Essex. Dr Kad is currently a Senior Lecturer at the University of Kent where he is studying DNA repair mechanisms at the molecular level. DNA damage is the underlying mechanism by which cells transform into tumours and cancer. Therefore, a much clearer understanding of how DNA repair works will lead to new anti-cancer targets and a better understanding of how current methodologies work.
Prof Steven M. Pollard
Cancer Research UK Senior Research Fellow
Chair of Stem Cell and Cancer Biology
MRC Centre for Regenerative Medicine, The University of Edinburgh
Prof Pollard's laboratory studies the molecular and cellular mechanisms that regulate neural stem self-renewal and differentiation, and how these operate in the context of human brain tumours. He is also co-leading the new Edinburgh-UCL Glioma Cellular Genetics Resource.
Steve was an undergraduate in Biochemistry at the University of Bath, which included a 6-month placement at St Jude Children's Research Hospital (Memphis, USA).
This stimulated his interest in molecular and cellular mechanisms that control normal development, stem cells, and cancer.
His PhD studies in zebrafish genetics were carried out at the MRC National Institute for Medical Research (NIMR) in the division of Developmental Biology (Lab of Dr Derek Stemple).
From there he moved his research into mammalian stem cell biology, working as a postdoctoral scientist with Prof Austin Smith FRS, at the University of Edinburgh, and latterly at the University of Cambridge. Here, as a Wellcome Beit Fellow he focused on neural stem cells and glioblastoma, and had a fruitful collaboration with Prof Peter Dirks (Sick Kids, Toronto).
He established his own independent laboratory in 2010 at the new UCL Cancer Institute, before moving in 2013 to the MRC Centre for Regenerative Medicine and Edinburgh Cancer Research Centre (Edinburgh). He holds the prestigious Cancer Research UK Senior Fellowship, and in 2017 was awarded the Chair of Stem Cell and Cancer Biology.
His laboratory continues to study the molecular and cellular mechanisms that regulate neural stem self-renewal and differentiation, and how these operate in the context of human brain tumours. New technologies emerging from stem cell biology, genome editing and and mammalian synthetic biology have opened up tremendous new opportunities to tackle glioblastoma – particularly for new target discovery and drug screening.
Dr Verena Amberger-Murphy
Translational Research Leader,
Head of the Translational and the Radiotherapy Department
Operations Lead for CNS and paediatric tumours
Cancer Trials Ireland
Dr Murphy is a member of the leadership team in Cancer Trials Ireland and responsible for the oversight and execution of operational strategies for multiple programs in the oncology portfolio, and for liaising with external stakeholders (funders, other charities).
Dr Murphy graduated with a PhD in Biochemistry from the University of Zurich, Switzerland, and worked at a variety of academic and clinical research laboratories in Germany, Switzerland, Canada and Ireland with a focus on cancer research, in particular brain tumours.
In 2009, Dr Murphy took up a position as Translational Research Coordinator in the strategic research cluster 'Molecular Therapeutics for Cancer Ireland (MTCI)' directed by consultant medical oncologist Prof John Crown and started working in this capacity in the All Ireland Cooperative Oncology Research Group (ICORG), today Cancer Trials Ireland. In 2015, she became Clinical Programme Leader, and in 2017 Translational Research Leader.
Prof Anthony J Chalmers
Anthony Chalmers is Chair of Clinical Oncology at the University of Glasgow. In addition to his neuro-oncology clinical practice he runs the Translational Radiation Biology laboratory in the Institute for Cancer Sciences and is Chief Investigator of a series of early phase clinical trials in glioblastoma.
His research aims to improve outcomes for cancer patients by combining radiotherapy with molecular targeted drugs. He is Chair of CTRad, founder of the UK Radiotherapy-Drug Combinations Consortium (RaDCom) and a Scientific Committee member of the European Association for Neuro-Oncology (EANO) and the European Society for Radiation Oncology (ESTRO).


text:
Mozambique: Mix and Match Covid-19 Vaccine Study to Take Place in Mozambique
Agencia de Informacao de Mocambique (Maputo)
Mozambique's National Health Institute (INS) will carry out research to investigate the effectiveness of mixing two approved Covid-19 vaccines.
A statement from the International Vaccine Institute (IVI) on 20 December announced that the INS-led Phase II trial will look at the safety and immunogenicity of a two-dose regimen using one dose of Sinopharm's VeroCell Covid-19 vaccine and one dose of the Johnson & Johnson vaccine administered 28 days apart. This will be compared with the effectiveness of the single source vaccines.
Both vaccines are approved and are part of Mozambique's COVID-19 vaccine rollout program.
There is evidence from around the world that mixing vaccines can produce a greater immune response. In addition, schedules where the second dose is not necessarily the same as the first allows for more flexibility in the event of vaccine shortages.
According to the deputy director of IVI, Doctor Florian Marks, "demonstrating the safety and efficacy of a mixed schedule of COVID-19 vaccines will have a significant impact on ensuring timely vaccinations and controlling the pandemic, particularly in the regions most affected by vaccine shortages".
She added, "amid an ongoing global pandemic with inequitable and interrupted access to vaccines, it is vital to make available a good, or potentially even better, alternative to the homologous dose schedules we have relied on so far".
The Phase II trial is an observer-blind and randomised study. A total of 360 participants will be enrolled in the study with follow-ups until 48 weeks after the second vaccination. It is funded by the Coalition for Epidemic Preparedness Innovations (CEPI) and is part of a US$12.7 million project for Expanding Access and Delivery of COVID-19 Vaccines in Africa (ECOVA).
Top Headlines Mozambique Coronavirus
Since it was launched in 2017, CEPI has focussed on developing vaccines against the Ebola virus, Lassa virus, Middle East Respiratory Syndrome coronavirus, Nipah virus, Rift Valley Fever virus and Chikungunya virus and has over twenty vaccine candidates against these pathogens in development. The organisation is a partnership between public, private, philanthropic, and civil organisations.
IVI is a non-profit intergovernmental organisation established in 1997 through an initiative launched by the United Nations Development Programme (UNDP).
The INS is the national public health and research institute in Mozambique, an autonomous public entity that functions under the umbrella of the Ministry of Health. Its mission is to improve well-being through the generation of scientific and technological solutions for public health problems in Mozambique.
Read the original article on AIM.
Copyright © 2022 Agencia de Informacao de Mocambique. All rights reserved. Distributed by AllAfrica Global Media (allAfrica.com). To contact the copyright holder directly for corrections — or for permission to republish or make other authorized use of this material, click here.


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text:
Challenges in very large distributed systems
SI: FOME - The Future of Middleware
Maarten van Steen1,
Guillaume Pierre1 &
Spyros Voulgaris1
Journal of Internet Services and Applications volume 3, pages 59–66 (2012)Cite this article
Many modern distributed systems are required to scale in terms of their support for processes, resources, and users. Moreover, a system is often also required to operate across the Internet and across different administrative domains. These scalability requirements lead to a number of well-known challenges in which distribution transparency needs to be traded off against loss of performance. We concentrate on two major challenges for which we claim there is no easy solution. These challenges originate from the fact that users and system are becoming increasingly integrated and are effectively leading us to large-scale socio-technical distributed systems. We identify the design of such integrated systems as one challenge, in particular when it comes to placing humans in the loop as a necessity to proper operation of the system as a whole. As users are so tightly integrated into the overall design, and systems naturally expand through composition, we will be facing problems with respect to long-term management, which we identify as another major challenge.
Download to read the full article text
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VU University Amsterdam, Amsterdam, The Netherlands
Maarten van Steen, Guillaume Pierre & Spyros Voulgaris
Maarten van Steen
Guillaume Pierre
Spyros Voulgaris
Correspondence to Maarten van Steen.
Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
van Steen, M., Pierre, G. & Voulgaris, S. Challenges in very large distributed systems. J Internet Serv Appl 3, 59–66 (2012). https://doi.org/10.1007/s13174-011-0043-x
Issue Date: May 2012
Socio-technical systems


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text:
Mintaka (delta Orionis) is een heldere ster in het sterrenbeeld Orion.

De ster bestaat uit een magnitude 6 ster die om een spectroscopische dubbelster draait. Deze laatste bestaat uit twee hete reuzensterren die elk een lichtkracht bezitten van 70.000 keer die van de Zon en zo'n twintigmaal zo zwaar zijn.

De ster staat ook bekend als Mintika en ligt vrijwel op de hemelevenaar. Mintaka is de rechter ster van het opvallende rijtje van drie sterren die de gordel van Orion uitbeelden. De andere twee sterren zijn Alnitak en Alnilam.

Systeem
Mintaka is een dubbelster rechts in de Gordel van Orion, en heeft een magnitude van +7, ongeveer 52 boogminuten van de hoofdster staat er nog een zwakkere ster tussen. De primaire component is spectroscopisch, en bevat een klasse B reus en een kleinere maar hetere ster van klasse O. De sterren draaien elke 5,73 dagen om elkaar heen. Deze sterren zijn elk 90.000 keer zo lichtsterk als de zon en hebben een gezamenlijke massa van ca. 40 zonnemassa's.

Externe link

Magnitude +2 ster
Dubbelster
Ster in Orion
Type O-helderereus


An intrusion detection system is improved by altering its signatures and thresholds during a denial of service attack, in order to decrease the rate at which an intrusion detection sensor sends alerts to an intrusion detection server. A governor within the sensor is associated with each signature. The governor may include an alert log, a timer, an alert-generation-rate threshold, and rules that prescribe actions to be taken when the alert-generation-rate threshold is exceeded. The governor records the generation time of each alert by the sensor, and determines the rate at which the sensor is presently generating alerts. When the present alert-generation rate exceeds the alert-generation-rate threshold, the governor alters the associated signature threshold to decrease the alert generation rate of the intrusion detection sensor.
Thus, the governor automatically alters signature sets to decrease the generation of alerts when the intrusion detection sensor's present alert-generation rate exceeds the alert-generation-rate threshold. As a result, the demands on the intrusion detection server are reduced during a denial-of-service attack, and the intrusion detection server is less likely to be overwhelmed by its own intrusion detection sensors. Consequently, the performance of the intrusion detection system is improved, and the attack upon the protected device will not cause the denial-of-service condition on the intrusion detection system. These and other aspects of the invention will be more fully appreciated when considered in the light of the following detailed description and drawings.
FIG. 5 shows housekeeping operations associated with the intrusion detection sensor of FIG. 2.
FIG. 1 shows an exemplary environment that is suitable for use of the present invention. In FIG. 1, a protected device  100 such as a computer, web server, workstation, or other similar device is connected to the Internet 110 or other communication network. Messages flow to the protected device 100 from sources local to the protected device 100, or from other sources (not shown) also connected to the Internet 110 or other communication network. Some of these messages may be emissaries of an attempt to intrude upon the protected device 100, such as an attempt to impede the operation of the protected device 100 by a denial-of-service attack. FIG. 1 also shows an intrusion detection system 200, the primary purpose of which is to detect such intrusions by alerting an administrator 120 of suspected intrusions. The intrusion detection system 200 includes an intrusion detection server 210 and an intrusion detection sensor 220. Although FIG. 1 shows only a single protected device 100 and a single intrusion detection sensor 220, the intrusion detection server 210 may protect more than one device and may have more than one intrusion detection sensor.
FIG. 2 shows aspects of the structure of an intrusion detection sensor  220 according to the present invention. As shown in FIG. 2, the inventive intrusion detection sensor 220 includes logic 250, which may be a programmable processor and which oversees the operation of the intrusion detection sensor 220, a governor 260, and a signature file 300. The governor 260, which may be implemented as instructions executed by the logic 250, includes a log 261. Occurrences of alerts generated by the intrusion detection sensor 220 are recorded in the log 261; in one embodiment of the invention, the log is simply a list of timestamps that record the times at which the intrusion detection sensor 220 generates alerts. The timestamps may be used as described below to determine the present alert-generation rate of the intrusion detection sensor 220 (i.e., the rate at which the intrusion detection sensor 220 generates alerts at present). The governor 260 may also include a timer 262 for entering timestamps into the log 161, an alert-generation-rate threshold 263, which serves a point of comparison for the present alert-generation rate, and a rule or set of rules 264 that may be applied to elements of a signature set in response to the outcome of a comparison of the present alert-generation rate with the alert-generation-rate threshold 263. Operation of the timer 262, alert-generation-rate threshold 263, and rules 264 may be carried out by instructions executed by the logic 250.
FIG. 3 illustrates an exemplary structure of the signature file  300, wherein three exemplary signature sets 301 through 303 are shown. The number three is selected here only for purposes of illustration; the present invention encompasses numbers of signature sets both greater than three and less than three as well as equal to three. As shown in FIG. 3, the signature sets 301 through 303 may include signature set identifiers 301A through 303A, signature events 301B through 303B, signature event counters 301C through 303C, signature threshold quantities 301D through 303D, and signature threshold intervals 301E through 303E. Thus, each signature set makes an association among a signature set identifier, a signature event, a signature event counter, a signature threshold quantity, and a signature threshold interval.
Within the signature sets  301 through 303 of FIG. 3, the signature set identifiers 301A through 303A may include alphanumeric tags, such that no two of the individual signature sets 301 through 303 have signature set identifiers 301A through 303A with equal alphanumeric values.
Within the signature sets  301 through 303 of FIG. 3, the signature events 301B through 303B may include bit patterns or other identifiers suggestive of attempted intrusions. For example, one of the signature events 301B through 303B might be a bit pattern associated with the event "Protocol violation 3" that is known to be a prelude to a denial-of-service attack. Another of the signature events 301B through 303B might be a bit pattern associated with the event "arrival of a message from source ID aaa.bbb.ccc.ddd," where the specified source ID is known to have been used in the past by a hacker.
Within the signature sets  301 through 303 of FIG. 3, the signature event counters 301C through 303C keep count of the numbers of occurrences of the associated signature events 301B through 303B, recording timestamps associated with the arrival of each counted signature event. With each occurrence of a signature event, the value of the associated signature event counter may be increased by one and a timestamp recorded (or just the timestamp recorded and the number of timestamps counted later); this method of operation is not a necessary condition of the present invention, however, and a signature event counter may be incremented or decremented in other ways responsive to the occurrence of an associated signature event.
Within the signature sets  301 through 303 of FIG. 3, the signature threshold intervals 301E through 303E may include intervals of time used as sliding windows that remove signature events past a specified age from the counts maintained by the signature event counters 301C through 303C. For example, a signature event interval 301E of five minutes would specify that an occurrence of a signature event 301B more than five minutes old should be taken out of the count maintained by the associated signature event counter 301C.
As discussed below, the rules  264 may be imposed upon elements of the signature sets, including the signature events 301B through 303B, the signature threshold quantities 301D through 303D, or the signature threshold intervals 301E through 303E, causing these elements to be altered advantageously in response to the beginning or ending of a denial-of-service attack.
FIG. 4 shows aspects of the operation of the logic  250 of the intrusion detection sensor 220 according to the present invention. For clarity, the operation of the logic 250 is described below when applied to one individual signature set 301 of the signature file 300; the same operations apply, of course, to the other signature sets held by the signature file 300 of the intrusion detection sensor 220.
As shown in FIG. 4, the intrusion detection sensor  220 monitors system activity involving the protected device 100, awaiting the occurrence of the signature event 301B (step 400). Until the signature event 301B occurs, the intrusion detection sensor 220 continues to monitor for the occurrence of the signature event 301B (step 400).
Otherwise (i.e., the signature event  301B occurs), the value of the associated signature event counter 301C is updated accordingly, for example increased by one (step 405). The value of the signature event counter 301C is then compared with the associated signature threshold quantity 301D (step 410), which, as mentioned above, is maintained according to a sliding time window specified by the associated signature threshold interval 301E (i.e., entries past an age specified by the signature threshold interval 301E are removed from the count of the signature event counter 301C). If the value of the signature event counter 301C does not exceed the associated signature threshold quantity 301D, the intrusion detection sensor 220 returns to await the arrival of another occurrence of the signature event 301B (step 400).
Otherwise (i.e., the value of the signature event counter  301C exceeds the signature threshold quantity 301D, and a potential intrusion has therefore been detected), the intrusion detection sensor 220 generates an alert and sends the alert to the intrusion detection server 210 (step 415).
The governor  260 enters the time the alert is generated into the log 261 (step 420), and if more than one signature set is under consideration enters the appropriate signature set identifier 301A, and then clears the log 261 of any entries that are past a permissible age (step 430). The permissible age may be tied to the alert-generation-rate threshold and the cap to be imposed by the governor 160 upon the rate of generation of alerts by the intrusion detection sensor 220. For example, if the cap were a maximum output of 100 alerts in two seconds, then the alert-generation-rate threshold could be 100 and the permissible age could be two seconds.
The governor  260 then determines the present alert-generation rate of the intrusion detection sensor 220 (step 440). For example, the present alert-generation rate may be computed by counting the number of timestamps found in the log 261, and dividing the result by the permissible age (or equivalently by multiplying the number of timestamps by a coefficient proportional to the permissible age). The present alert-generation rate is then compared with the alert-generation-rate threshold 263 (step 450). If the present alert-generation rate does not exceed the alert-generation-rate threshold 263, the intrusion detection sensor 220 returns to monitor for the occurrence of the signature event 301B (step 400).
Otherwise (i.e., the present alert-generation rate exceeds the alert-generation-rate threshold  263), the governor 260 alters one or more elements of the signature file 301 in order to decrease the alert generation rate (step 460) of the intrusion detection sensor 220. The governor 260 may increase the value of the signature threshold quantity 301D relatively or absolutely (e.g., quadruple the value of the signature threshold quantity, or change "alert on five occurrences of the signature event" to "alert on twenty occurrences of the signature event"), decrease the signature threshold interval 301E relatively or absolutely (e.g., halve the signature threshold interval, or change "30 seconds" to "15 seconds"), or suspend the generation of alerts on the occurrence of the signature event 301B altogether (e.g., "stop generating alerts based on observation of protocol violation 3"). The intrusion detection sensor 220 then returns to monitor for the occurrence of the signature event 301B (step 400).
FIG. 5 shows the operation of ancillary aspects of the intrusion detection sensor  220. The governor 260 awaits the occurrence of a scheduled update time (step 500). When the current time is not a scheduled update time, the governor 260 continues to await the occurrence of a scheduled update time (step 500). Otherwise (i.e., the current time is a scheduled update time), the governor 260 clears the log 261 of any entries that are past the permissible age described above (step 510). This is a regularly scheduled operation to clear the log 261 in the absence of the immediate occurrence of the signature event 301B, and is in addition to the event-driven clearing of the log 261mentioned above (in step 430 of FIG. 4). The governor 260 then determines the present alert-generation rate (step 520), in order to determine whether the denial-of-service attack has ended, in which case the intrusion detection set 301 may be restored to its initial state. For example, the present alert-generation rate may be computed by counting the number of timestamps in the log 261, and dividing the result by the permissible age. The present alert-generation rate is then compared with the alert-generation-rate threshold 263 (step 530).
If the present alert-generation rate exceeds the alert-generation-rate threshold  263, the governor 260 returns to monitor for the occurrence of an update time (step 500), as the denial-of-service attack is evidently still ongoing. Otherwise (i.e., the present alert-generation rate does not exceed the alert-generation-rate threshold 263), the governor 260 determines whether the signature set 301 is at its initial state (step 540), which is the state of the signature set 301 prior to any changes made by the governor 260 in the course of the operations described above with reference to FIG. 4.
If the signature set  301 is at its initial state, the governor 260 returns to await a scheduled update time (step 500). Otherwise (i.e., the signature set 301 is not at its initial state), the governor 260 alters one or more elements of the signature set 301 (step 550). For example, the governor 260 may decrease the value the signature threshold quantity 301D relatively or absolutely (e.g., quarter the signature threshold quantity, or change "alert on twenty occurrences of the signature event" to "alert on five occurrences of the signature event"), increase the signature threshold interval 301E relatively or absolutely (e.g., double the signature threshold interval," or change "15 seconds" to "30 seconds"), or resume the generation of alerts on the occurrence of the signature event 301B suspended earlier (e.g., "resume generating alerts based on observation of protocol violation 3").
altering an element of a signature set of the intrusion detection system responsive to an outcome of the step of comparing.
when the present alert generation rate exceeds the alert generation rate threshold, altering an element of a signature set of the intrusion detection sensor to decrease an alert generation rate of the intrusion detection sensor.
3. The method of claim 2, wherein the element is a signature threshold quantity.
4. The method of claim 2, wherein the element is a signature threshold interval.
when the present alert generation rate exceeds the alert generation rate threshold, altering an element of a signature set of an intrusion detection system to decrease an alert generation rate of an intrusion detection sensor.
6. The method of claim 5, wherein the element is a signature threshold quantity.
7. The method of claim 5, wherein the element is a signature threshold interval.
when the present alert generation rate exceeds the alert generation rate threshold, altering an element of a signature set of an intrusion detection system to decrease an alert generation rate of an intrusion detection server.
11. The programmable media of claim 10, wherein the element is a signature threshold quantity.
12. The programmable media of claim 10, wherein the element is a signature threshold interval.
ES2282739T3 (en) 2007-10-16 Method and system for preventing intrusion and rejection.


text:
Q: Issues running Java Mission Control from CLI on Windows 10 because of JNI library errors? I am trying to run Java Mission Control on my windows 10 machine and have so far not been able to get it to work. I have tried some of the distributions from this list. I tried the Zulu Mission Control, and AdoptOpenJDK, as well as building from source (had other issues with building from source). When Trying with Azul and AdoptOpenJDK I downloaded the zip files, unzipped them and tried to run the respective mission control programs. I ran them from the cmd prompt on windows 10.
From searching online the error I get seems related to Eclipse. Though I want to run this from the CLI and I don't have eclipse installed. Here is the error:
Failed to load the JNI shared library
"C:\IBM\InformationServer_113/jdk32\jre\bin\j9vm\jvm.dll"

Is there something I'm missing here?
Here is what I get when I run "java -version" from cmd prompt.
java version "1.7.0"
Java(TM) SE Runtime Environment (build pwi3270_27sr1-20140411_01(SR1))
IBM J9 VM (build 2.7, JRE 1.7.0 Windows x86-32 20140410_195893 (JIT enabled, AOT enabled)
J9VM - R27_Java727_SR1_20140410_1931_B195893
JIT  - tr.r13.java_20140410_61421
GC   - R27_Java727_SR1_20140410_1931_B195893
J9CL - 20140410_195893)
JCL - 20140409_01 based on Oracle 7u55-b13


The Disaster Supplemental Nutrition Assistance Program offers short-term food assistance benefits to families recovering from a disaster. D-SNAP is designed to help when people return to their homes and have access to electricity and grocery stores. Benefits are loaded on a Lone Star Card within three days of applying, and the amount is equal to two months of the maximum amount of SNAP benefits, based on household size.
Be from a county that has been declared a federal disaster area*.
You must apply in person at a designated D-SNAP location in your county of residence. You will not be able to apply online. D-SNAP applications will be accepted for a limited amount of time in each county. See below for designated D-SNAP locations.
Residents in Harris County may only apply between Sept. 22 and Oct. 5. Designated D SNAP Locations will be open daily from 8 a.m. to 7 p.m. unless otherwise noted.
If you enroll in D-SNAP and you are pregnant or have a child younger than 5, you are also eligible for WIC. This allows you to get healthy foods such as fruit and vegetables, cereal, bread and milk, as well as breastfeeding assistance, infant formula and help from nutritionists and other sources. Visit TexasWIC.org(link is external) or call 800-942-3678 for more information.


im a newbie motovlogger from malaysia.
I ride a pulsar ns200 and a honda airblade 125 (its a scooter). Well, i do like a short trip to an eatery or maybe for a little sight seeing.
Why im here, well..... Just a few friends from everywhere maybe.... Riders dont have any borders right?
this is my honda airblade 125i, this picture is taken during my last ride with my friends frmn honda vario owner club johor bahru, on the first week of january.
Hi @Mr Chippy welcome to the forum The bags on the NS200 look neat!
Hi and I agree with you that riders have no borders. Welcome!
Ya! We are all brothers and sisters!
My exhaust is quite high on the bike so need to take that into consideration!
Them palms sure looks lovely, wish I could ride underneath them all day long!
Welcome to the forum! Cool bike and awesome scooter!
Ya, and i normally will ride the scooter more than the red beast. Hahahahaha #autorules!


The framework contract runs for seven years and includes an option for the supply of a further 105 Elefant 2 vehicles. This means a total order value of €122 million (including VAT) for 137 vehicles. Following the Bundeswehr's award in July 2017 of a major contract to Rheinmetall MAN Military Vehicles for unprotected transport vehicles ("Ungeschützte Transportfahrzeuge", or UTF), the latest order is another major sales success for the company in Germany.
With the Elefant 2 on the way, the Bundeswehr's family of heavyweight transport vehicles continues to grow. The unprotected Elefant 2 complements the protected Mammut heavy-duty transporter, likewise supplied by Rheinmetall MAN Military Vehicles.
Particularly in light of Germany's obligation in 2023 to furnish NATO's Very High Readiness Joint Task Force (VJTF 2023), being able to transport heavy combat vehicles will be a key capability.


Deph's New Mouse (Logitech G600) Review and Setup.
I wanted to make a post regarding my new mouse, the Logitech G600 since I know many of us use Razer Nagas, and this is Logitech's version. Finally!
Posting it in this forum as I also go into detail on how my keybinds and bars are set up in WoW. Just in case it's useful to somebody using a similar device setup.
Not going to bother posting an image, it's a Naga with left and right scroll, and a "third" mouse button on top, for your ring finger, designed to be a modifier key. By default this key just makes all the other buttons on the mouse act as though the CTRL key is pushed... But I wanted to bind it to CTRL to use as a modifier key for other stuff as well... So that's what I did!
The number one reason I wanted the mouse. It uses Logitech's Gaming Software, which is pretty much the best toolkit out there for binding your keys, making macros and such. Linking it to the profiles I use for almost every game on my G13. I always disliked the Razer software.
Thumbpad on the G600 curved so you can tell the buttons apart much more easily.
Like all of Logitech's gaming mice, it has a lot of different customizability options, including DPI shift, customizable per game. When I say "DPI Shift" I mean it, you can bind a 'modifier key' style button to shift the mouse's DPI... and since it uses the Logitech Gaming Software, that button is now a pinky key on the G13 (for FPS games) letting me hit it with my left hand, rather than having to (sometimes) press 3 buttons on the mouse simultaneously to use the functionality.
Last, and definitely least: LED lighting changes colors along with my G13, and it matches it perfectly. Can change based on profile, best indicator as to if it fucked up and didn't load the game you're playing's profile ever. And now I don't feel I need to make all my G13's profiles BLUE to match the Naga... WoW is now Monk aqua FTW!
Unable to bind Left and Right scroll to... Anything, let alone Left and Right Scroll. -- They can be bound to my G930 (headset) and G13 (pad) which... uh... aren't mice... (the "Mouse Function" menu has a "Scroll functions" subheader that the G600 does not have) But cannot be bound to the mouse, lol.
G series devices do not have the capability to support unified "Modes" I was really hoping Gshift would be able to shift my G13 as well, but it doesn't. -- No biggy here, just a quality of life thing.
Last edited by Deph; 08-30-2012 at 10:02 PM.
TLDR UI and Keybind setup.
The G13s two Bartender bars page with Ctrl, Alt, and Shift.
The G600 bar pages to the same secondary bar when any modifier key is pressed.
This uses all 10 bars, all 120 buttons. I, of course, use only a portion of them, but it's nice not having to make modifier key macros, lol.
SHIFT is secondary abilities, CC, PVP crap I don't use often in raids, all that junk a lot of people just never bother keybinding.
CTRL pages to Heals (or DPS, if I'm a healer) -- Which is nice if I respec between heals/dps, just swap the profile in bartender to swap all the buttons!
ALT is self cast heals, buffs, potions, flasks, weapons for swapping, that sort of stuff. -- Alt self cast is a lifesaver on a healer in PvP.
In-game screenshots and graphics to follow, UI is a disaster right now just to make it work for the raid tonight.
I customized my keybinds to keep buttons I'm more likely to accidentally hit on the keyboard from having important cooldowns bound to them.
Here's a spreadsheet I made to help me figure it all out. I'll make some much nicer graphics once I know I've got the binds how I want them... Need to mess around on the beta first.
This list does not include what keys can be HIT with modifiers (paging bars, macros, etc) nor does it detail which buttons have bizzare keybinds when you press a modifier (like the numberkeypad becoming home/end/del etc) It also doesn't point out that, if you use the alt key at all, binding F4 is a disaster waiting to happen.
Last edited by Deph; 07-23-2012 at 05:30 PM.
Great review. I have the Razer Naga and like it, but would have purchased the G600 if given the option today.
Personally, I find the Naga to be a bit small, so if you have smaller hands it would fit you well. The G600 looks like a great product with a better ergonomic layout of the side buttons. I find on the Naga it's hard to use buttons 7-12 and have relegated myself to only using the 1-6 with Shift/CTRL/ALT binds. Still plenty for my setup. I haven't messed with the G600, but my G5 was a great size for my hand and have found Logitech to sometimes be a little larger form compared to Razer products. Also, I like the fact that the G600 has the left and right scroll... Basically I'm a little jelly right now of your mouse!!!
Oh yeah, I neglected to go into detail about how the thumbpad felt.
The Naga's size worked good for me as I tend to hold the mouse with my fingertips rather than palming it. -- The G600 is only a little TALLER, and a bit wider (for the third mouse button) - The extra height makes it harder to fingertip grip it, but overall I think it'll be more comfortable once I'm used to it.
On the Naga I could barely hit all of the buttons. 1-3 were the very tip of my thumb, and 10-12 were the base of my thumb. Everything in-between was on an indented part of my thumb, and always took me a moment to make sure I had the correct buttons. They lacked the definition to really identify them quickly, so I never felt comfortable putting important things on them.
The G600, the top row (1-3 on the Naga, but G9-G11 on the G600) is actually slightly past my thumb-tip but the fact that I can easily identify every button actually makes them easier to hit, even if I have to shift my grip a bit. Meanwhile I already feel as comfortable hitting the buttons with the G600 as I did with the Naga, and I'm sure that's only going to improve.
Edit: this problem has been fixed in the latest update.
Added a BIG Con. Although it doesn't bother me at all. It's pretty dumb.
The "G-Shift" functionality which makes the mouse swap modes when you push a button down, releases ALL BUTTONS (even if you're holding down the key still) even left and right click when you press it. Considering you pretty much LIVE with the right mouse button down for a good chunk of MMO gameplay, this is baaad.
I didn't notice myself as I immediately rebound G-shift to CTRL, and never looked back, as it's much easier to just bind the keys in game than play with the logitech gaming software, but noticed it when I went to go use G-Shift with a game that didn't let me change it's keybinds.
If I REALLY wanted that kind of functionality, I could always write an autohotkey script to detect the HID input from the mouse and manually script out anything I wanted. -- (I had to do this with the Steel Series MMO mouse when it first came out, as it's software was even buggier than this logitech mess) But that's not something most people aren't up to doing, lol.
Last edited by Deph; 08-30-2012 at 10:12 PM.
The most recent update fixed every bug and issue I've had for the most part with the G600 save for two issues.
• Still unable to bind Left and Right scroll to ... left and right scroll, lol.
• Each G series device having it's own modes... Still the same. No big deal here.
My name is Brian and I just happened to stumble upon your forum post regarding your G600. Very well done, I'd like to add. May I ask you a follow-up question concerning your configuration?
You've illustrated that you have rebound "G-Shift" to be "Right Ctrl". I can't seem to get that mapping to stick with my setup. Essentially I am interested utilizing the "G-Shift" to act as my focus modifier for all of my focus based CC abilities such as Clone, Roots, Hibernate, etc.
So, my question is how do I convert "G-Shift" into "Ctrl"?
I have it set to Right Ctrl because that way I can press it down when I have Left Ctrl hit with my left hand, and release one of the two, without both buttons getting the "up" signal sent.
Thank you for your reply. There still seems to be something not quite right about how I'm going about this.
I am currently running the latest version of LGS 64-bit (8.35.18) on Windows 7 64-bit. LGS is running in "Automatic Game Detection" mode and in a new profile that I have created for WoW setting the path to the executable manually. Of course I am missing all of the default binds that LGS likes to establish but I'm not overly worried about those. I'll create them in the future as I feel they become necessary.
Current Config: Running AGD mode, custom WoW profile is active and using the 2nd mouse profile defaulting with the num pad for binding options.
I enter the binding configuration screen, click on the "G-Shift" button, edit, select "Keystroke", cursor over the binding field and hit the "Ctrl" key on my keyboard. The text over the key now reflects my alteration. It seems that it would be as simple as this but no dice.
The desired bind is plainly visible there, however when I enter the "test mode" displaying every keystroke entered the newly mapped "G-Shift" come "Ctrl" key does not display any output. Subsequently it does not trigger my focus modifier in-game either. This leads me to believe that somehow my configuration of the software is the limiting factor.
Do you have any additional thoughts in light of the current details? Perhaps the steps I have taken to configure my G600 are glaringly incorrect and you may spot something out of order.
I'd suggest posting to Logitech's gaming mouse support forums if you haven't already. If for no other reason than to report what is apparently a bug.
A lot of people wipe out problems that sound like yours by deleting all of LGS' settings and starting from scratch. -- I had to do this to fix my LED coloring, which kept defaulting to the original "rainbow" setting, no matter what I changed the setting to.
To quote a Logitech Support moderator "Uninstall LGS, delete the settings.json file in C:\Users\%USER%\AppData\Local\Logitech\Logitech Gaming Software\ , then reinstall"