Fred W. Groff, 87, of Hummelstown passed away Tuesday, April 9, 2019 in the Hershey Medical Center.
Born March 9, 1932 in Ephrata, he was the son of the late Christian R. and Elizabeth (Hicks) Groff and was preceded in death by his sister Eleanor Fellows.
A 1949 graduate of East Lampeter High School and 1953 graduate of Millersville College, Fred then served in the U. S. Army from 1953 – 1955. Following his marriage to Erika Holz in 1954, he attended Bethany Bible Seminary and graduated in 1960 from Lancaster Theological Seminary after which his pastorates included Hollidaysburg, Evansville, Indiana and Winchester, Virginia. He later worked at Quaker Oats Company and most recently was a self-employed landlord.
Fred's interests included reading, religious discussions, listening to religious philosophical lectures, singing Perry Como songs and bird watching. When able, he enjoyed flying, owning two airplanes and a paraplane. His most enjoyment came from his grandchildren and great grandchildren.
Surviving are his wife of 64 years Erika H. (Holz) Groff; sons Steven F. Groff of Hummelstown and Alex W., husband of Monika Groff of Lebanon; grandchildren Andrew Groff (married to Samantha Groff), Rachel Groff, Martin Groff (married to Ashlin Groff), Peter Groff; and great grandchildren Amirah and Josiah Groff.
A funeral service will be held 2:00 PM Saturday, April 13th at Hanoverdale Church of the Brethren, 577 Hershey Road, Hummelstown preceded by a viewing beginning at 1:00 PM. Interment in Hanoverdale Cemetery.
In lieu of flowers, contributions may be made to Brethren Housing Association, 219 Hummel Street, Harrisburg, PA 17104 or a charity of the donor's choice.


Robert Malley was born in 1963 and lived in France from 1969-80. His mother—a native New Yorker—worked for the United Nations delegation of the National Liberation Front, the leftist, anti-American political party that led the independence movement in Algeria in the 1950s and early '60s. Robert's father, the late Simon Malley, was a key figure in the Egyptian Communist Party. The elder Malley was bitterly anti-Israel; a confidante of PLO leader Yasser Arafat; an inveterate critic of "Western imperialism"; a supporter of various leftist revolutionary "liberation movements," particularly the Palestinian cause; a beneficiary of Soviet funding; and a backer of the 1979 Soviet invasion of Afghanistan.
Robert Malley attended Yale University and in 1984 was a Rhodes Scholar at Oxford, where he earned a Ph.D. in political philosophy. He then went on to earn a J.D. at Harvard Law School, which he attended at the same time as Barack Obama. And in 1991–92, Malley clerked for Supreme Court Justice Byron White.
After his clerkship, Malley became a Fellow at the Council on Foreign Relations, where he published The Call From Algeria: Third Worldism, Revolution, and the Turn to Islam—a book that charts Algeria's political evolution beginning from the turn of the 20th century.
Since 2001, Malley has written several controversial articles—some were co-authored with Hussein Agha, a former advisor to Arafat—blaming Israel and exonerating Arafat for the failure at Camp David. For instance, in a July 2001 op-ed (titled "Fictions About the Failure at Camp David") which was published in the New York Times, Malley alleged that Israeli—not Palestinian—inflexibility had caused the previous year's peace talks to fail.
"Middle East Triangle": Co-written with Hussein Agha, this January 2008 piece calls for Hamas and Fatah to end their bitter disputes and to join forces in an effort to derail what the authors view as Israel's attempt to "perpetuate Palestinian geographic and political division." Malley and Agha predict that such a strategy would prompt Hamas to: (a) abandon its longstanding quest to destroy Israel; and (b) encourage Palestinian Authority President Mahmoud Abbas (a leading member of Fatah) to negotiate for a lasting peace with Israel.
"The U.S. Must Look to its Own Mideast Interests": Co-written with Aaron David Miller, this September 2006 article urges the U.S. to engage with Syria and Hamas, rather than to "follow Israel's lead." Malley and Miller add: "A national unity government between Fatah and Hamas appears within reach, and the Europeans seem prepared to resume assistance to such a government once it takes shape. Should this happen, America shouldn't stand in the way -- regardless of whether Hamas recognizes Israel or formally renounces violence. Instead, the United States should see this as an opportunity to achieve what is achievable: a Palestinian cease-fire involving all armed organizations, a halt to all Israeli offensive military actions, and the resumption of normal economic life for the Palestinian government and people."
At that time, Malley was the Middle East and North Africa Program Director for the International Crisis Group (ICG), which receives funding from the Open Society Institute (whose founder, George Soros, serves on the ICG Board and Executive Committee). In his capacity with ICG, Malley directed a number of analysts based in Amman, Cairo, Beirut, Tel Aviv, and Baghdad. These analysts reported periodically on the political, social and economic factors which they believed had the potential to spark conflict in those regions, and they made policy recommendations in an effort to defuse such threats. Covering events from from Iran to Morocco, Malley's team focused most heavily on the Arab-Israeli conflict, the political and military developments in Iraq, and Islamist movements across the Middle East.
On November 5, 2008, Middle East Newsline reported that Obama "had sent senior foreign-policy advisor Robert Malley to Egypt and Syria over the last few weeks to outline the Democratic candidate's policy on the Middle East." The report added that Malley had "relayed a pledge from Obama that the United States would seek to enhance relations with Cairo as well as reconcile with Damascus." "The tenor of the messages was that the Obama administration would take into greater account Egyptian and Syrian interests," said an aide to Malley.
After President Obama's 2012 reelection, he appointed Malley to serve as his senior advisor for Iraq-Iran-Syria and the Gulf states. Obama pledged, however, that Malley would have no involvement in issues related to Israel and the Palestinians.
Malley has been a member of J Street's advisory council for a number of years.


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Bob Saget Wrote A Touching Message To 'Full House' Co-star Jodie Sweetin On Her Birthday
Copyright AP
AP
By: Kate Streit
On Jan. 19, actor Jodie Sweetin celebrated her 39th birthday. Bob Saget, her "Full House" co-star, took to Twitter to send her well wishes and included an adorable photo of the pair from their days on the hit sitcom together as well as a more recent photo, showing how their bond has spanned the years.
"Happy birthday @JodieSweetin!" Saget wrote in the tweet. "You haven't changed at all! Why do people say that? You've turned from an adorable sweet little girl to an adorable empowered young woman. Proud to be your friend all these years and always. Oh, it's Bob."
Happy Birthday @JodieSweetin ! You haven't changed at all! Why do people say that? You've turned from an adorable sweet little girl to an adorable empowered young woman. Proud to be your friend all these years and always. Oh, it's Bob. pic.twitter.com/yMoSnnYHFJ
— bob saget (@bobsaget) January 20, 2021
Aww! The sweet garnered more than 2,000 likes, and many fans replied to wish Sweetin a happy birthday as well. On Instagram, Sweetin herself replied.
Love you so so much!!! ❤❤" she wrote in response to Saget's post.
Saget played Danny Tanner, the patriarch on the family sitcom that ran for eight seasons from 1987 to 1995. Sweetin starred as Stephanie Tanner, one of his three daughters. The cast later reunited for a sequel series, "Fuller House," which had five seasons on Netflix from 2016 to 2020. Throughout the years, the TV co-stars remained friends and have frequently talked about their offscreen relationships.
In 2019, Saget noted that he has a real-life daughter close to Sweetin's age. When asked if he shared a paternal bond with Sweetin from when they were filming "Full House," he answered that he did.
"When Jodie Sweetin was 9 years old, my daughter Aubrey was 7, and so they would play together, and Jodi slept over at the house," he told Closer Weekly, joking, "I felt like friends to everyone. They're women and I'm not an ageist."
Sweetin has also spoken out about the close relationships she has built with her co-stars.
"The things that I remember the most about growing up on television were not the things that happened in front of the camera," she said during a lecture at Penn State in 2020. "But is really the family and the stuff that we built behind the scenes."
Happy birthday to Sweetin!
This Fake Tweet Looks So Real Even Savvy Users Might Be Fooled
TikTok Is Banning MLM And Pyramid Scheme Content
Wilmer Valderrama And Fiancée Amanda Pacheco Are Expecting Their First Child
People Are Cutting Cake With Wine Glasses And It's Kind Of Brilliant

redpajama_set_name: RedPajamaCommonCrawl


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Ray Dalio: The Next Crash Is Coming
Benjamin Shepherd December 15, 2019 at 08:30 Bear MarketsInvesting
An investment legend is warning that the next bear market is just around the corner.
He correctly called the last global financial crisis, yet still made billions of dollars in the market.
Click here to find out how you can, too.
Ray Dalio is an investment legend, and when he says the markets are in trouble, people listen. Especially when he puts his money where his mouth is.
Dalio has been sounding the alarm, warning that too many investors believe that stocks that have run up are "better rather than more expensive." He's also been preaching the value of diversification in a bear market, which can reduce your risk without reducing your return.
So, what's he so worried about?
Last month, he made a LinkedIn post which laid out a gloomy view of the global economy, titled "The World Has Gone Mad and The System Is Broken."
In it, he points out that asset prices have gone way up and expected future returns have gone way down, all because of hyper-low interest rates.
He's also bothered by all the tech companies which have gone public – with no profits – but have still managed to sell stock to the public. He worries that those companies are selling dreams, not sustainable businesses.
He's also worried about the massive government deficits around the world, which will require even more debt to be sold just to keep governments running. That's eventually going to require interest rates to jump to levels that would be "devastating for markets and economies because the world is so leveraged."
Why should you care what Dalio thinks?
From his modest beginnings growing up in Queens, the son of a jazz musician, he went on to found Bridgewater Associates. It manages about $160 billion in global investments and runs one of the world's largest hedge funds. Now personally worth nearly $18 billion, one of Dalio's greatest claims to fame is correctly calling the global financial crisis in 2007.
Dalio is so pessimistic, his hedge fund is betting against the stock markets. It's laid on $1.5 billion worth of complex bets that either the S&P 500, the Euro Stoxx 50, or both, will fall by March. Granted, that's less than 1% of the fund's assets, but that's still a massive wager that shows just how worried Dalio is.
What's the average investor, who can't afford to make $1.5 billion bets, to do about the coming bear market?
Take Dalio's advice and diversify, diversify, diversify. He believes in the "60-40" rule, meaning the average portfolio should be 60% stocks and 40% bonds.
As evidenced by his hedge fund, he also believes in diversifying across investment strategies. Based on what information is publicly available, his fund holds stocks and bonds, and uses options and futures strategies.
And now, you can, too.
Sign up for our free, no-obligation workshop, and we'll show you how to invest like Ray Dalio. You can use his strategy to lock in $1,098 or even $5,244 in extra monthly income just by mimicking Dalio's investment strategy.
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Laser-Cut Gingerbread People - 4 Sizes Available!
Start creating cute and simple projects with these darling laser-cut Gingerbread People! Each shape has been pre-cut and pre-fused for quick and easy applique fun. These laser shapes are perfect for beginners and quilters of all skill levels. Each shape is a different color. We have 4 sizes available, listed below. Fabrics may vary from the image, but have been carefully chosen to replicate the originals shown.


This is a demonstration experiment which can either be used for fun as part of a public event or in a class to stimulate discussion of the conditions required for combustion.
The quantities given are for one demonstration.
Ethanol, C2H5 OH(l) (HIGHLY FLAMMABLE) - see CLEAPSS Hazcard .
Industrial Denatured Alcohol (IDA) (HARMFUL, HIGHLY FLAMMABLE) - see CLEAPSS Hazcard.
1 Prepare some pieces of absorbent paper, e.g. filter paper, about the size of a £5 note.
2 Place about 50 cm3 of water in one beaker, a similar volume of ethanol in a second beaker, and a mixture of 25 cm3 water and 25 cm3 ethanol in the third beaker. Add a little (about 1 g) of sodium chloride to the third beaker and stir until it has all dissolved. Label the beakers.
b Place the Bunsen burner on the heat-resistant mat and adjust it to give a yellow flame. Ensure that the beakers of ethanol, water, and the ethanol-water mixture are a safe distance (2 m) away from the Bunsen burner.
c Using the tongs, soak one piece of paper in the water in the first beaker. Allow the paper to drain. Try to ignite it by holding it in the Bunsen flame for a few seconds. It does not ignite.
d Soak a second piece of paper in ethanol and use the tongs to hold it in the Bunsen flame just long enough for it to ignite. Take care to drip as little alcohol as possible on the bench between the beaker and the Bunsen burner. The alcohol on the paper ignites easily and sets fire to the paper, which burns away.
e Soak the third piece of paper in the alcohol-water mixture and use the tongs to hold it in the Bunsen flame just long enough for it to ignite. Swiftly remove the paper from the Bunsen flame and observe as the alcohol burns with a yellow flame, but the paper does not burn. The paper will still be wet with water after the alcohol has burnt away.
A wealthy and/or confident demonstrator can start this experiment with a £5, or even higher value, note and the alcohol-water mixture! More amusement can be added if a member of the audience 'with money to burn' can be persuaded to part with the money. It is important to use a yellow Bunsen flame, and to only hold the paper in the flame long enough for it to ignite, to prevent the note from burning. The demonstrations with ordinary paper and the other liquids could then follow to provide an explanation.
The water in the alcohol-water mixture evaporates as the alcohol burns, keeping the temperature of the paper below its ignition temperature (approximately 230°C). Converting this temperature to the Fahrenheit scale can also allow for a discussion of the use of this scale and for the 'keen' science fiction fans a discussion about the Novel and Film 'Fahrenheit 451'. See Fahrenheit 451 .
The flame from the paper soaked in alcohol alone should be visible but the flame from a burning alcohol-water mixture is often difficult to see. This is why the sodium chloride is added, to give an orange-yellow colour to the flame. The demonstration looks even more impressive in subdued lighting.


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Week 10 NFL Game Watchability Rankings
The best game of the week comes on Thursday night.
NFLBy Brad Gagnon on November 8, 2018 November 7, 2018
Week 10 of the 2018 NFL regular season is here. You might be entering the weekend with your own preferences regarding which games to focus on, and which to place on the backburner.
Most of you have your favorite teams and fantasy players to track. But in case you're completely neutral or need help breaking ties regarding what to watch, we've ranked all 14 games on the schedule from most appealing to least enticing.
1. Panthers at Steelers (Thursday night, FOX/NFLN): Cam Newton vs. Ben Roethlisberger is nice, and both teams are super-hot right now. Plus, the Steelers can send a message to Le'Veon Bell on national TV.
2. Seahawks at Rams (Sunday, 4 p.m. ET, CBS): Russell Wilson has quite frequently been magical of late and the Rams are suddenly beatable. Seattle needs this, and it should put up a fight in L.A.
3. Jaguars at Colts (Sunday, 1 p.m. ET, CBS): The loser is basically toast, and Indy might have the edge at home. This should be interesting.
4. Saints at Bengals (Sunday, 1 p.m. ET, FOX): Cincinnati should put up a fight coming off a bye against a Saints team that has been through the ringer the last few weeks. If so, this'll be a good second-half watch.
5. Lions at Bears (Sunday, 1 p.m. ET, FOX): Desperate Detroit against a contending Bears team. Not bad, especially if the Lions can keep it close on the road.
6. Cowboys at Eagles (Sunday night, NBC): A good old rivalry between two strong markets, and both teams are desperate for the W.
7. Patriots at Titans (Sunday, 1 p.m. ET, CBS): New England is gaining steam, but the Titans could keep this close at home after a big road victory in Dallas. Plus, there are a lot of interesting connections between these teams (Malcolm Butler's revenge?).
8. Redskins at Buccaneers (Sunday, 1 p.m. ET, FOX): Washington is a complete mess, and the Bucs aren't in much better shape. Still, you know this'll probably contain fourth-quarter drama.
9. Dolphins at Packers (Sunday, 4 p.m. ET, CBS): Look for Green Bay to bounce back in desperation mode and destroy a mediocre Miami team at Lambeau. Not much sex appeal there.
10. Falcons at Browns (Sunday, 1 p.m. ET, FOX): Meh. This'll likely be a blowout. Merely monitor it until or unless it's close late.
11. Giants at 49ers (Monday night, ESPN): It could at least be close? Plus, the Giants are at least entertaining in a point-and-laugh kind of way, and Nick Mullens gives this some buzz.
12. Cardinals at Chiefs (Sunday, 1 p.m. ET, CBS): The Chiefs are massive favorites. In KC, don't expect this to be competitive.
13. Chargers at Raiders (Sunday, 4 p.m. ET, FOX): Unless the Raiders are hanging around late, don't bother with this likely blowout. Oakland is a joke.
14. Bills at Jets (Sunday, 1 p.m. ET, CBS): Sam Darnold and possibly Nathan Peterman? This painful game could break a record for turnovers.
About Brad Gagnon
Brad Gagnon has been passionate about both sports and mass media since he was in diapers -- a passion that won't die until he's in them again. Based in Toronto, he's worked as a national NFL blog editor at theScore.com, a producer and writer at theScore Television Network and a host, reporter and play-by-play voice at Rogers TV. His work has also appeared at CBSSports.com, Deadspin, FoxSports.com, The Guardian, The Hockey News and elsewhere at Comeback Media, but his day gig has him covering the NFL nationally for Bleacher Report.
View all posts by Brad Gagnon	Follow on Twitter
Cam Newton offers man $1,500 to change seats on 10-hour flight, man says no
Bob Ley had a career at ESPN that people can only dream of today
Before free agency begins, we imagine some potential NBA superteams based on the current market


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Janusz Brzeszczynski
Prof Janusz Brzeszczynski
Department: Newcastle Business School
Before joining NBS, Professor Janusz Brzeszczyński worked at Heriot-Watt University in Edinburgh and held a number of visiting positions at the universities abroad in the USA, Germany, Switzerland and Poland.
He was awarded Fulbright scholarship (Senior Grant) at the Arizona State University in the USA, Humboldt Fellowship for Experienced Researchers at the University of Münster in Germany, ESKAS federal scholarship at the Swiss Institute of Banking of Finance at the University of St.Gallen in Switzerland and DAAD research scholarship at the Kiel University in Germany.
Professor Janusz Brzeszczyński published in such top journals as: "Journal of International Money and Finance", "Journal of Comparative Economics", "Journal of International Financial Markets, Institutions and Money", "Journal of Business Ethics", "European Journal of Finance", "International Review of Economics and Finance", "Applied Financial Economics", "International Review of Financial Analysis", "Journal of Pension Economics and Finance", "Emerging Markets Finance and Trade", "International Journal of Finance and Economics", "Finance Research Letters", "Expert Systems with Applications", "Journal of Financial Stability", "Energy Journal" and "Energy Economics", among others.
He acted also as a consultant for Reuters and did research projects for various banks and other financial institutions.
Professor Janusz Brzeszczyński served on the Editorial Board of the "Emerging Markets Finance and Trade" journal and he is currently a Senior Editor at the "International Journal of Emerging Markets" and an Associate Editor at the "Finance Research Letters" journal.
His other roles at the NBS included in the past the Acting Head of the AFM department and the Director of Research in the AFM department. Professor Janusz Brzeszczyński is currently the Head of Subject Group (Finance) in the AFM department.
Professor Janusz Brzeszczyński was invited to present his research at such financial institutions as BlackRock in San Francisco, RiskLab in Munich or National Bank of Poland (NBP) in Warsaw and at the research seminars at top research universities such as the University of California San Diego (UCSD), IESE Business School in Barcelona, University of San Francisco (USF) and Booth School of Business at the University of Chicago.
Email Janusz
Please visit the Pure Research Information Portal for further information
Do Business Models Matter? Evidence from the SRI Companies Performance and the COVID-19 Pandemic, Press, M., Brzeszczyński, J. 1 Aug 2022, In: Finance Research Letters
Do Investment Fund Managers Behave Rationally in the Light of Central Bank Communication? Survey Evidence from Poland, Bolek, M., Wolski, R., Gajdka, J., Kutan, A., Brzeszczyński, J. 9 Dec 2022, In: Qualitative Research in Financial Markets
Has the Risk of Socially Responsible Investments (SRI) Companies Stocks Changed in the COVID-19 Period? International Evidence, Brzeszczyński, J., Gajdka, J., Pietraszewski, P., Schabek, T. 1 Oct 2022, In: Finance Research Letters
Rethinking financial contagion: Information transmission mechanism during the COVID-19 pandemic, Yarovaya, L., Brzeszczyński, J., Goodell, J., Lucey, B., Lau, C. 1 Jul 2022, In: Journal of International Financial Markets, Institutions and Money
Systemic Risk Measures and Regulatory Challenges, Ellis, S., Sharma, S., Brzeszczyński, J. 1 Aug 2022, In: Journal of Financial Stability
The COVID-19 storm and the energy sector: The impact and role of uncertainty, Szczygielski, J., Brzeszczyński, J., Charteris, A., Bwanya, P. 1 May 2022, In: Energy Economics
The impact and role of COVID-19 uncertainty: A global industry analysis, Szczygielski, J., Charteris, A., Bwanya, P., Brzeszczyński, J. 1 Mar 2022, In: International Review of Financial Analysis
Which COVID-19 information really impacts stock markets?, Jakub Szczygielski, J., Charteris, A., Rutendo Bwanya, P., Brzeszczyński, J. 27 May 2022, In: Journal of International Financial Markets, Institutions and Money
Central bank's communication and markets' reactions: Polish evidence, Brzeszczyński, J., Gajdka, J., Schabek, T., Kutan, A. 7 Sep 2021, In: International Journal of Emerging Markets
How Much Do the Central Bank Announcements Matter on Financial Market? Application of the Rule-Based Trading System Approach, Brzeszczyński, J., Gajdka, J., Schabek, T., Kutan, A. 15 Nov 2021, In: Expert Systems with Applications
PGR Supervision
Larisa Yarovaya Return and Volatility Transmission in Emerging and Developed Stock Markets Start Date: 08/09/2014 End Date: 05/04/2016
Imanol Cazalis Tabusalla Start Date: 19/05/2014
Financial Management PhD September 01 1995
Fellow (FHEA) Higher Education Academy (HEA) 2015
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Applying for EDA is easier than ever. Start by selecting the program for which you are interested in applying.
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The Illinois Department of Public Health has rejected intractable pain and autism spectrum disorder as medical conditions that could be treated with medical cannabis.
The petition to add intractable pain to the medical marijuana program was submitted in July 2015 to the Medical Cannabis Advisory Board.
Department of Public Health Director Nirav Shah on Monday noted in rejecting the petition that none of information submitted demonstrated an individual diagnosed with intractable pain could benefit from medical cannabis.
Shah also pointed out no evidence was presented in a petition submitted in October 2015 that a person diagnosed autism spectrum disorder would benefit from the use of marijuana.
Illinois law lists dozens of diseases, including cancer, multiple sclerosis and AIDS, that can qualify a patient for cannabis use with a doctor's recommendation and a state ID card.


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6814 Formally Deprecating Some IPv4 Options.
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7568 Deprecating Secure Sockets Layer Version 3.0.
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The Visitation of Vicente Masip
Sometimes the recognition of the value of the work of Juan Vicente Masip (c. 1473 –1551) has been somewhat hidden under the prestige of his son, Juan de Juanes, also a painter and highly valued thanks to paintings such as the Institution of the Holy Eucharist. So much so that in many of his mature works, the most exquisite, a shared authorship between father and son is usually proposed, who shared a workshop and commissions from his city:Valencia.
In fact, the vast majority of the altarpieces and panels painted by Masip were intended for temples in the Valencian city or surrounding towns. And his initial influences are certainly based on theValencian school, but soon you will see Italian nuances in his paintings. Firstly, because some works by Sebastiano del Piombo arrived in the Valencian capital, which were to have enormous strength, not only in Masip's way of painting, but in reality of all his contemporaries. But it is also speculated that Vicente Masip may have traveled to Italy, and more specifically to Rome and Umbría where I would get to know first-hand the work of Rafael, of whom echoes are discovered in his compositions. Including this circular table that he would make between the years 1540 and 1545.
Here we can see a composition with a very Italian air, with ascene in which Saint Elizabeth kneels before her daughter the Virgin Mary, while Saint Joseph and Zechariah are further back.
The raphaelism is evident both in the harmony emanating from the scene and in the different gestures shown by the characters. But instead, Masip is not only dedicated to being inspired and following the great teacher. He was a creator with his own personality and variety of influences. For this reason, the landscape that can be seen in the background is reminiscent of the Flemish painting that were so well known in Spain during the 16th century.
The circular format is due to the fact that at that time this type of painting called tondo was highly appreciated, and the truth is that this Visitación was a double work, since it was a pair with another circular table that represents The Martyrdom of Saint Agnes. Both were painted to be included in an altarpiece in the chapel of Santo Tomás de Villanueva inside the Valencian convent of San Julián. However, today the two panels are part of the collection of the Museo del Prado in Madrid, since they were acquired in the 19th century by King Fernando VII.


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Hank Williams Jr. Tickets
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Asperger syndrome (AS), also known as Asperger disorder (AD) or simply Asperger's, is an autism spectrum disorder (ASD) that is characterized by significant difficulties in social interaction and nonverbal communication, alongside restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development. Although not required for diagnosis, physical clumsiness and atypical (peculiar, odd) use of language are frequently reported. Symptoms include social awkwardness, loud vocalizations, atypical speech, emotional detachment or over-attachment, anger management issues, and narrow interests that may become obsessive. Those with AS usually feel like they don't "fit in" with society. They're often smarter, more creative, or more observant than their peers and can excel in life when given a chance.
The syndrome is named after the Austrian pediatrician Hans Asperger who, in 1944, studied and described children in his practice who lacked nonverbal communication skills, demonstrated limited empathy with their peers, and were physically clumsy. The modern conception of Asperger syndrome came into existence in 1981 and went through a period of popularization, becoming standardized as a diagnosis in the early 1990's. Many questions remain about aspects of the disorder. There is doubt about whether it is distinct from high-functioning autism (HFA), partly because of this, its prevalence is not firmly established. The diagnosis of Asperger's was eliminated in the 2013 fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and replaced by a diagnosis of autism spectrum disorder on a severity scale.
As a pervasive developmental disorder, Asperger syndrome is distinguished by a pattern of symptoms rather than a single symptom. It is characterized by qualitative impairment in social interaction, by stereotyped and restricted patterns of behavior, activities and interests, and by no clinically significant delay in cognitive development or general delay in language.
A lack of demonstrated empathy has a significant impact on aspects of communal living for persons with Asperger syndrome. Individuals with AS experience difficulties in basic elements of social interaction, which may include a failure to develop friendships or to seek shared enjoyments or achievements with others (for example, showing others objects of interest), a lack of social or emotional reciprocity (social "games" give-and-take mechanic), and impaired nonverbal behaviors in areas such as eye contact, facial expression, posture, and gesture.
People with AS may not be as withdrawn around others compared to those with other, more debilitating, forms of autism; they approach others, even if awkwardly. For example, a person with AS may engage in a one-sided, long-winded speech about a favorite topic, while misunderstanding or not recognizing the listener's feelings or reactions, such as a wish to change the topic of talk or end the interaction. This social awkwardness has been called "active but odd." This failure to react appropriately to social interaction may appear as disregard for other people's feelings, and may come across as insensitive. However, not all individuals with AS will approach others. Some of them may even display selective mutism, speaking not at all to most people and excessively to specific people. Some may choose to talk to only people they like.
Individuals with AS often have excellent auditory and visual perception. Children with ASD often demonstrate enhanced perception of small changes in patterns such as arrangements of objects or well-known images; typically this is domain-specific and involves processing of fine-grained features. Conversely, compared to individuals with high-functioning autism, individuals with AS have deficits in some tasks involving visual-spatial perception, auditory perception, or visual memory. Many accounts of individuals with AS and ASD report other unusual sensory and perceptual skills and experiences. They may be unusually sensitive or insensitive to sound, light, and other stimuli; these sensory responses are found in other developmental disorders and are not specific to AS or to ASD. There is little support for increased fight-or-flight response or failure of habituation in autism; there is more evidence of decreased responsiveness to sensory stimuli, although several studies show no differences.
Although individuals with Asperger syndrome acquire language skills without significant general delay and their speech typically lacks significant abnormalities, language acquisition and use is often atypical. Abnormalities include verbosity, abrupt transitions, literal interpretations and miscomprehension of nuance, use of metaphor meaningful to only the speaker, auditory perception deficits, unusually pedantic, formal or idiosyncratic speech, and oddities in loudness, pitch, intonation, prosody, and rhythm. Echolalia has also been observed in individuals with AS.
Three aspects of communication patterns are of clinical interest: poor prosody, tangential and circumstantial speech, and marked verbosity. Although inflection and intonation may be less rigid or monotonic than in classic autism, people with AS often have a limited range of intonation: speech may be unusually fast, jerky or loud. Speech may convey a sense of incoherence; the conversational style often includes monologues about topics that bore the listener, fails to provide context for comments, or fails to suppress internal thoughts. Individuals with AS may fail to monitor whether the listener is interested or engaged in the conversation. The speaker's conclusion or point may never be made, and attempts by the listener to elaborate on the speech's content or logic, or to shift to related topics, are often unsuccessful.
Diagnosis is most commonly made between the ages of four and eleven. A comprehensive assessment involves a multidisciplinary team that observes across multiple settings, and includes neurological and genetic assessment as well as tests for cognition, psychomotor function, verbal and nonverbal strengths and weaknesses, style of learning, and skills for independent living. The "gold standard" in diagnosing ASDs combines clinical judgment with the Autism Diagnostic Interview-Revised (ADI-R)—a semistructured parent interview—and the Autism Diagnostic Observation Schedule (ADOS)—a conversation and play-based interview with the child. Delayed or mistaken diagnosis can be traumatic for individuals and families; for example, misdiagnosis can lead to medications that worsen behavior. Many children with AS are initially misdiagnosed with attention deficit hyperactivity disorder (ADHD). Diagnosing adults is more challenging, as standard diagnostic criteria are designed for children and the expression of AS changes with age; adult diagnosis requires painstaking clinical examination and thorough medical history gained from both the individual and other people who know the person, focusing on childhood behavior. Conditions that must be considered in a differential diagnosis include other ASDs, theschizophrenia spectrum, ADHD, obsessive–compulsive disorder, major depressive disorder, semantic pragmatic disorder, nonverbal learning disorder, Tourette's syndrome, stereotypic movement disorder, bipolar disorder. and social-cognitive deficits due to brain damage from alcohol abuse.
Hans Asperger described common symptoms among his patients' family members, especially fathers, and research supports this observation and suggests a genetic contribution to Asperger syndrome. Although no specific gene has yet been identified, multiple factors are believed to play a role in the expression of autism, given the phenotypic variability seen in children with AS. Evidence for a genetic link is the tendency for AS to run in families and an observed higher incidence of family members who have behavioral symptoms similar to AS but in a more limited form (for example, slight difficulties with social interaction, language, or reading. Most research suggests that all autism spectrum disorders have shared genetic mechanisms, but AS may have a stronger genetic component than autism. There is probably a common group of genes where particular alleles render an individual vulnerable to developing AS; if this is the case, the particular combination of alleles would determine the severity and symptoms for each individual with AS.
Care must be taken with medications, as side effects may be more common and harder to evaluate in individuals with AS, and tests of drugs' effectiveness against comorbid conditions routinely exclude individuals from the autism spectrum. Abnormalities in metabolism, cardiac conduction times, and an increased risk of type 2 diabetes have been raised as concerns with these medications, along with serious long-term neurological side effects. SSRIs can lead to manifestations of behavioral activation such as increased impulsivity, aggression, and sleep disturbance. Weight gain and fatigue are commonly reported side effects of risperidone, which may also lead to increased risk for extrapyramidal symptoms such as restlessness and dystonia and increased serum prolactin levels. Sedation and weight gain are more common with olanzapine which has also been linked with diabetes. Sedative side-effects in school-age children have ramifications for classroom learning. Individuals with AS may be unable to identify and communicate their internal moods and emotions or to tolerate side effects that for most people would not be problematic.
6. Training and support of parents, particularly in behavioral techniques to use in the home.
Of the many studies on behavior-based early intervention programs, most are case reports of up to five participants and typically examine a few problem behaviors such as self-injury, aggression, noncompliance, stereotypes, or spontaneous language; unintended side effects are largely ignored. Despite the popularity of social skills training, its effectiveness is not firmly established. A randomized controlled study of a model for training parents in problem behaviors in their children with AS showed that parents attending a one-day workshop or six individual lessons reported fewer behavioral problems, while parents receiving the individual lessons reported less intense behavioral problems in their AS children. Vocational training is important to teach job interview etiquette and workplace behavior to older children and adults with AS, and organization software and personal data assistants can improve the work and life management of people with AS.
There is some evidence that children with AS may see a lessening of symptoms; up to 20% of children may no longer meet the diagnostic criteria as adults, although social and communication difficulties may persist. As of 2006, no studies addressing the long-term outcome of individuals with Asperger syndrome are available and there are no systematic long-term follow-up studies of children with AS. Individuals with AS appear to have normal life expectancy, but have an increased prevalence of comorbid psychiatric conditions, such as major depressive disorder and anxiety disorder that may significantly affect prognosis. Although social impairment is lifelong, the outcome is generally more positive than with individuals with lower functioning autism spectrum disorders; for example, ASD symptoms are more likely to diminish with time in children with AS or HFA.
Although most students with AS/HFA have average mathematical ability and test slightly worse in mathematics than in general intelligence, some are gifted in mathematics and AS has not prevented some adults from major accomplishments such as winning the Nobel Prize.
Autism is a disorder that relates to neural development and is best characterized by impaired social interaction, restricted and repetitive behavior and lack of communication skills. The diagnostic criterion claims that symptoms become apparent within a child before they turn three years of age. Autism directly effects the processing of information in the brain by altering nerve cells and their proper synapses. Asperger's syndrome is a disorder that lies within the autism spectrum, and is best characterized by significant difficulties in social interaction.
Medical marijuana has been known to be a solution to alleviating outbursts of rage, seizures and temper tantrums among autism patients. Cannabis and cannabis-based products such as concentrates and tinctures can be responsible for the lessening of any erratic actions that may have occurred in the past. Patients who use medical marijuana to treat their symptoms become extremely relaxed and very attentive to what they are doing. Best put, medical marijuana can serve as an exceptional behavioral modification, which can protect both the health and safety of an autistic patient.
Medical Marijuana can be used to alleviate the negative symptoms and accentuate the positive aspects of Asperger's Syndrome.
Tetrahydrocannabinol (THC) and Cannabidiol (CBD) are the two main cannabinoids found in marijuana. THC is psychoactive, causing the "high" associated with marijuana use. CBD is non-psychoactive and has a calming effect. Aspies should choose high quality medical marijuana that has a high CBD to THC ratio. Use tinctures and edibles for long-lasting effects. Smoke or vaporize marijuana for a quick fix. Mix buds and leaf together to get more CBD's in your medicine.
Anxiety issues can make it impossible to lead a productive life. CBD's calm the body and mind to relieve stress. but beware of high THC concentrations that can cause severe anxiety and panic attacks.
Aspies are often ruled by their emotions and can have temper-tantrums well into adulthood. Smoke or vaporize marijuana as soon as you feel the anger rising and you should be able to calm down enough to talk about your feelings.
Sufferers of AS can have stress management issues due to their inability to control emotions. This can lead to disorders of the gastrointestinal system, such as ulcerative colitis, inflammatory bowel disease, and Crohn's Disease. Marijuana has pain-relieving and anti-inflammatory properties that can ease discomfort. If you are malnourished, use marijuana to stimulate your appetite.
Stress and depression can make it impossible to get a good night's sleep. Marijuana can help you fall asleep and stay asleep.
Aspie brains can race out of control making it difficult to concentrate and communicate. Marijuana slows down your thought processes, enabling you to think clearly and focus on one subject at a time.
Marijuana can alleviate social phobias, allowing you to leave the house and interact with the world without worrying about feeling different.


text:
Тельбес — посёлок (с 1932 по 1966 год — рабочий посёлок) в Таштагольском районе Кемеровской области. Входит в состав Мундыбашского городского поселения.

География
Посёлок Тельбес расположен в северо-западной части Таштагольского района на берегах реки Тельбес, в месте впадения в неё реки Тамала, в 9 километрах от посёлка Мундыбаш.

Центральная часть населённого пункта расположена на высоте 257 метров над уровнем моря.

В посёлке 4 улицы — Кирова, Левобережная, Натяжная и Озёрная.

История
Тельбес — один из старейших шорских аалов.

Ещё в середине XVIII века делались попытки использовать железные руды Тельбесского месторождения для снабжения Томского завода, но из-за большой удалённости и отсутствия дорог эта задача оказалась непосильной.

В 1926 году постановлением Сибирского крайисполкома были начаты работы по организации бюро для проектирования Тельбесского Кузнецкого комбината — Тельбесбюро, на базе которого впоследствии был организован Тельбесстрой, а позже — Кузнецкстрой.

29 января 1930 года в посёлке Тельбес организовано управление Тельбесского железорудного района по строительству рудников Тельбес и Темиртау, а в сентябре была начата проходка первой на руднике Тельбес наклонной шахты «Ударник».

Руду из рудника вывозили по рельсам в вагонетках, а далее — до Мундыбаша по канатной дороге, протяжённость которой составляла 7050 метров и была рассчитана на перевозку 300000 тонн руды в год. Последняя руда по канатной дороге отправлена в 1948 году, после чего дорога была демонтирована и перенесена на соседний рудник Одрабаш.

Постановлением ВЦИК от 2 марта 1932 года отнесён к категории рабочих посёлков.

Указом Президиума Верховного Совета РСФСР от 23 марта 1961 года Тельбес передан в состав Таштагольского района.

Решением Кемеровского облисполкома № 96 от 31 января 1966 года Тельбес отнесён к категории сельских поселений и передан в административное подчинение Мундыбашского поссовета.

Население

Примечания

Населённые пункты Таштагольского района
Бывшие посёлки городского типа Кемеровской области

redpajama_set_name: RedPajamaWikipedia


text:
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease
Ana Griciuc, Shaun Patel, Anthony N. Federico, Se Hoon Choi, Brendan J. Innes, Mary K. Oram, Gea Cereghetti, Danielle McGinty, Anthony Anselmo, Ruslan I. Sadreyev, Suzanne E. Hickman, Joseph El Khoury, Marco Colonna, Rudolph E. Tanzi
Division of Immunobiology
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
Siteman Cancer Center
Bursky Center for Human Immunology & Immunotherapy Programs (CHiiPs)
Center for Brain Immunology & Glia (BIG)
Rheumatic Diseases Research Resource-Based Center
DBBS - Immunology
DBBS - Molecular Microbiology and Microbial Pathogenesis
The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer's disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that knockout of CD33 attenuated amyloid beta (Aβ) pathology and improved cognition in 5xFAD mice, both of which were abrogated by additional TREM2 knockout. Knocking out TREM2 in 5xFAD mice exacerbated Aβ pathology and neurodegeneration but reduced Iba1+ cell numbers, all of which could not be rescued by additional CD33 knockout. RNA-seq profiling of microglia revealed that genes related to phagocytosis and signaling (IL-6, IL-8, acute phase response) are upregulated in 5xFAD;CD33−/− and downregulated in 5xFAD;TREM2−/− mice. Differential gene expression in 5xFAD;CD33−/− microglia depended on the presence of TREM2, suggesting TREM2 acts downstream of CD33. Crosstalk between CD33 and TREM2 includes regulation of the IL-1β/IL-1RN axis and a gene set in the "receptor activity chemokine" cluster. Our results should facilitate AD therapeutics targeting these receptors. Microglial receptors CD33 and TREM2 exhibit opposite effects on Aβ pathology and microglial activity in AD mice. In crosstalk between these receptors, TREM2 is required for differential gene expression in 5xFAD mice deficient for CD33 and acts downstream of CD33.
820-835.e7
https://doi.org/10.1016/j.neuron.2019.06.010
IL-1beta
amyloid beta
pathway analysis
Dive into the research topics of 'TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease'. Together they form a unique fingerprint.
Alzheimer Disease Medicine & Life Sciences 100%
Pathology Medicine & Life Sciences 81%
Microglia Medicine & Life Sciences 52%
Acute-Phase Reaction Medicine & Life Sciences 32%
Gene Expression Medicine & Life Sciences 30%
RNA-Seq Medicine & Life Sciences 30%
Interleukin-1 Medicine & Life Sciences 25%
Griciuc, A., Patel, S., Federico, A. N., Choi, S. H., Innes, B. J., Oram, M. K., Cereghetti, G., McGinty, D., Anselmo, A., Sadreyev, R. I., Hickman, S. E., El Khoury, J., Colonna, M., & Tanzi, R. E. (2019). TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease. Neuron, 103(5), 820-835.e7. https://doi.org/10.1016/j.neuron.2019.06.010
Griciuc, Ana ; Patel, Shaun ; Federico, Anthony N. et al. / TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease. In: Neuron. 2019 ; Vol. 103, No. 5. pp. 820-835.e7.
@article{bf938b1fdb3d4d21a474abb2e491aeb7,
title = "TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease",
abstract = "The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer's disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that knockout of CD33 attenuated amyloid beta (Aβ) pathology and improved cognition in 5xFAD mice, both of which were abrogated by additional TREM2 knockout. Knocking out TREM2 in 5xFAD mice exacerbated Aβ pathology and neurodegeneration but reduced Iba1+ cell numbers, all of which could not be rescued by additional CD33 knockout. RNA-seq profiling of microglia revealed that genes related to phagocytosis and signaling (IL-6, IL-8, acute phase response) are upregulated in 5xFAD;CD33−/− and downregulated in 5xFAD;TREM2−/− mice. Differential gene expression in 5xFAD;CD33−/− microglia depended on the presence of TREM2, suggesting TREM2 acts downstream of CD33. Crosstalk between CD33 and TREM2 includes regulation of the IL-1β/IL-1RN axis and a gene set in the "receptor activity chemokine" cluster. Our results should facilitate AD therapeutics targeting these receptors. Microglial receptors CD33 and TREM2 exhibit opposite effects on Aβ pathology and microglial activity in AD mice. In crosstalk between these receptors, TREM2 is required for differential gene expression in 5xFAD mice deficient for CD33 and acts downstream of CD33.",
keywords = "Alzheimer's, CD33, IL-1beta, RNA-seq, TREM2, amyloid beta, microglia, neuroinflammation, pathway analysis, transcriptomics",
author = "Ana Griciuc and Shaun Patel and Federico, {Anthony N.} and Choi, {Se Hoon} and Innes, {Brendan J.} and Oram, {Mary K.} and Gea Cereghetti and Danielle McGinty and Anthony Anselmo and Sadreyev, {Ruslan I.} and Hickman, {Suzanne E.} and {El Khoury}, Joseph and Marco Colonna and Tanzi, {Rudolph E.}",
note = "Funding Information: The research was supported by grants from the NIA/NIH ( K99AG049056 and 5R00AG049056 to A.G., 5R01MH060009 to R.E.T.), Cure Alzheimer's Fund (A.G. and R.E.T.), and JPB Foundation (R.E.T.). J.E.K. is supported by RF1 AG051506 . We thank the MGH Next Generation Sequencing Core, Adalis Maisonet, and Ulandt Kim for assistance in RNA-seq and DF/HCC Pathology Core for assistance in histopathology. Funding Information: The research was supported by grants from the NIA/NIH (K99AG049056 and 5R00AG049056 to A.G. 5R01MH060009 to R.E.T.), Cure Alzheimer's Fund (A.G. and R.E.T.), and JPB Foundation (R.E.T.). J.E.K. is supported by RF1 AG051506. We thank the MGH Next Generation Sequencing Core, Adalis Maisonet, and Ulandt Kim for assistance in RNA-seq and DF/HCC Pathology Core for assistance in histopathology. Conceptualization, A.G. and R.E.T.; Methodology, A.G. S.P. S.E.H. J.E.K. M.C. and R.E.T.; Software, S.P. A.N.F. A.A. and R.I.S.; Formal Analysis and Data Curation, A.G. S.P. A.N.F. and A.A.; Investigation, A.G. A.N.F. S.H.C. B.J.I. M.K.O. G.C. and D.M.; Resources, R.I.S. and M.C.; Writing ? Original, A.G. and R.E.T.; Writing ? Review and Editing, A.G. S.P. S.H.C. R.I.S. S.E.H. J.E.K. M.C. and R.E.T.; Visualization, A.G. S.P. A.N.F. S.H.C. and R.E.T.; Supervision, R.E.T.; Funding Acquisition, A.G. and R.E.T. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
doi = "10.1016/j.neuron.2019.06.010",
pages = "820--835.e7",
journal = "Neuron",
Griciuc, A, Patel, S, Federico, AN, Choi, SH, Innes, BJ, Oram, MK, Cereghetti, G, McGinty, D, Anselmo, A, Sadreyev, RI, Hickman, SE, El Khoury, J, Colonna, M & Tanzi, RE 2019, 'TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease', Neuron, vol. 103, no. 5, pp. 820-835.e7. https://doi.org/10.1016/j.neuron.2019.06.010
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease. / Griciuc, Ana; Patel, Shaun; Federico, Anthony N. et al.
In: Neuron, Vol. 103, No. 5, 04.09.2019, p. 820-835.e7.
T1 - TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease
AU - Griciuc, Ana
AU - Patel, Shaun
AU - Federico, Anthony N.
AU - Choi, Se Hoon
AU - Innes, Brendan J.
AU - Oram, Mary K.
AU - Cereghetti, Gea
AU - McGinty, Danielle
AU - Anselmo, Anthony
AU - Sadreyev, Ruslan I.
AU - Hickman, Suzanne E.
AU - El Khoury, Joseph
AU - Colonna, Marco
AU - Tanzi, Rudolph E.
N1 - Funding Information: The research was supported by grants from the NIA/NIH ( K99AG049056 and 5R00AG049056 to A.G., 5R01MH060009 to R.E.T.), Cure Alzheimer's Fund (A.G. and R.E.T.), and JPB Foundation (R.E.T.). J.E.K. is supported by RF1 AG051506 . We thank the MGH Next Generation Sequencing Core, Adalis Maisonet, and Ulandt Kim for assistance in RNA-seq and DF/HCC Pathology Core for assistance in histopathology. Funding Information: The research was supported by grants from the NIA/NIH (K99AG049056 and 5R00AG049056 to A.G. 5R01MH060009 to R.E.T.), Cure Alzheimer's Fund (A.G. and R.E.T.), and JPB Foundation (R.E.T.). J.E.K. is supported by RF1 AG051506. We thank the MGH Next Generation Sequencing Core, Adalis Maisonet, and Ulandt Kim for assistance in RNA-seq and DF/HCC Pathology Core for assistance in histopathology. Conceptualization, A.G. and R.E.T.; Methodology, A.G. S.P. S.E.H. J.E.K. M.C. and R.E.T.; Software, S.P. A.N.F. A.A. and R.I.S.; Formal Analysis and Data Curation, A.G. S.P. A.N.F. and A.A.; Investigation, A.G. A.N.F. S.H.C. B.J.I. M.K.O. G.C. and D.M.; Resources, R.I.S. and M.C.; Writing ? Original, A.G. and R.E.T.; Writing ? Review and Editing, A.G. S.P. S.H.C. R.I.S. S.E.H. J.E.K. M.C. and R.E.T.; Visualization, A.G. S.P. A.N.F. S.H.C. and R.E.T.; Supervision, R.E.T.; Funding Acquisition, A.G. and R.E.T. The authors declare no competing interests. Publisher Copyright: © 2019 Elsevier Inc.
N2 - The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer's disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that knockout of CD33 attenuated amyloid beta (Aβ) pathology and improved cognition in 5xFAD mice, both of which were abrogated by additional TREM2 knockout. Knocking out TREM2 in 5xFAD mice exacerbated Aβ pathology and neurodegeneration but reduced Iba1+ cell numbers, all of which could not be rescued by additional CD33 knockout. RNA-seq profiling of microglia revealed that genes related to phagocytosis and signaling (IL-6, IL-8, acute phase response) are upregulated in 5xFAD;CD33−/− and downregulated in 5xFAD;TREM2−/− mice. Differential gene expression in 5xFAD;CD33−/− microglia depended on the presence of TREM2, suggesting TREM2 acts downstream of CD33. Crosstalk between CD33 and TREM2 includes regulation of the IL-1β/IL-1RN axis and a gene set in the "receptor activity chemokine" cluster. Our results should facilitate AD therapeutics targeting these receptors. Microglial receptors CD33 and TREM2 exhibit opposite effects on Aβ pathology and microglial activity in AD mice. In crosstalk between these receptors, TREM2 is required for differential gene expression in 5xFAD mice deficient for CD33 and acts downstream of CD33.
AB - The microglial receptors CD33 and TREM2 have been associated with risk for Alzheimer's disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that knockout of CD33 attenuated amyloid beta (Aβ) pathology and improved cognition in 5xFAD mice, both of which were abrogated by additional TREM2 knockout. Knocking out TREM2 in 5xFAD mice exacerbated Aβ pathology and neurodegeneration but reduced Iba1+ cell numbers, all of which could not be rescued by additional CD33 knockout. RNA-seq profiling of microglia revealed that genes related to phagocytosis and signaling (IL-6, IL-8, acute phase response) are upregulated in 5xFAD;CD33−/− and downregulated in 5xFAD;TREM2−/− mice. Differential gene expression in 5xFAD;CD33−/− microglia depended on the presence of TREM2, suggesting TREM2 acts downstream of CD33. Crosstalk between CD33 and TREM2 includes regulation of the IL-1β/IL-1RN axis and a gene set in the "receptor activity chemokine" cluster. Our results should facilitate AD therapeutics targeting these receptors. Microglial receptors CD33 and TREM2 exhibit opposite effects on Aβ pathology and microglial activity in AD mice. In crosstalk between these receptors, TREM2 is required for differential gene expression in 5xFAD mice deficient for CD33 and acts downstream of CD33.
KW - Alzheimer's
KW - CD33
KW - IL-1beta
KW - RNA-seq
KW - TREM2
KW - amyloid beta
KW - microglia
KW - neuroinflammation
KW - pathway analysis
KW - transcriptomics
U2 - 10.1016/j.neuron.2019.06.010
DO - 10.1016/j.neuron.2019.06.010
SP - 820-835.e7
JO - Neuron
JF - Neuron
Griciuc A, Patel S, Federico AN, Choi SH, Innes BJ, Oram MK et al. TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease. Neuron. 2019 Sep 4;103(5):820-835.e7. doi: 10.1016/j.neuron.2019.06.010


The Water Survey has a new face in the Groundwater Science Section – Tyler Pierson. Tyler has been hired to replace hydrologist Mark Anliker after his retirement last month. Tyler started at the Illinois State Water Survey on Thursday, December 6 and is currently in Building 4, room 442, Mark Anliker's old office.
Tyler's position at ISWS primarily deals with an ongoing dewatering project in East St. Louis funded by the Illinois Department of Transportation (IDOT) and he is very excited about expanding his overall knowledge of groundwater in the American Bottoms region located across the Mississippi River from St. Louis. He hopes to gain a better understanding of the system - not just in terms of water quantity - but quality, behavior, and management practices. Ideally, he anticipates developing an up-to-date groundwater model that would help further IDOT's and the Survey's goals.
Tyler comes to us from Idaho where, as a non-traditional student, he earned his Bachelor's degree in Geology with a focus on Hydrogeology at the University of Idaho. He spent the next three years studying for his Master's degree in Water Resources Management and Engineering at the University of Stuttgart in Germany. His work experience ranges from welding, carpentry, and land surveying before going to college, to managing a wastewater treatment plant in Namibia for a three month internship during his Master's studies. He also held a position as a hydrology technician for the U.S. Forest Service as well as a number of laboratory positions both in Idaho (geophysical lab) and Germany (hydrochemical).
Tyler is particularly interested in water management in a general sense. He would like to keep the idea of responsible resource management in mind during all aspects of work and life. Recreationally, he enjoys anything outdoors. In Idaho he spent most summers backpacking in the Bitterroot Mountains and is currently exploring natural areas in the state of Illinois.


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Boxed Henley leatherette strap watch.
Only £8.50 each or only £8.15 each when bought in 10`s or more.


This tech news roundup features: Reports of Apple Talking Smart Watch for Seniors with MA, Google Assistant gets new features for CES 2019, and Unveiling of HoloLens 2.0 by Microsoft.
Apple is reportedly working with Medicare Advantage (MA) plans to bring its subsidized SmartWatch for the seniors. The Apple Watch will prove to be an asset for at-risk seniors. It is with advanced health tracking features, like fall detection (which is only turned on by default for customers 65 and older) and a built-in ECG, and more.
With more than 22.6 million beneficiaries signing up for Medicare plans in 2019, MA penetration is on pace to hit 50% by 2025 — and 70% sometime between 2030 and 2040. A CNBC report suggests that the company is discussing prospects with about three Medicare plan providers.
Apple is in discussion with several large and smaller private Medicare plans to find ways to offer the Smart device at subsidized prices. As per the report, the plan providers want Apple to showcase the benefits of features on AppleWatch. It is identified as one of the challenges. Though, it is expensive than the lower-end fitness trackers, the report highlights. It is estimated that the price of the said hardware will presumably come down with future versions offering long-term benefits.
Rishabh Software is a pioneer in offering iPhone app iWatch App development and testing services. Our team of iOS experts has thorough proficiency in iOS app architecture & implementation.
At the CES 2019, Google had a host of announcements along with the unveiling of new and advanced features for its Assistant. It is set to launch by the end of 2019.
One of the highlights of this AI software is a new mode for fast and efficient translation – the Interpreter. For example, Google Home speakers and connected screens will now be able to offer an instant translation service by asking, "Be my interpreter in English," or one of the 27 languages already available. Earlier intended for home usage, Google will use this feature for professional settings. It will enable you to have a real-time conversation in different languages.
Google Connect, a new platform linking your Assistant-enabled objects to your non-Google Assistant devices is set for launch by the end of 2019. Thanks to this, the devices will be able to retrieve information from your Google Assistant.
Thorough integration of Google's navigation system is the Google Assistant's Maps feature. It will allow users to add detours, respond to your messages and communicate the journey without dipping out of the navigation app.
The conference at MWC 2019 will feature Satya Nadella, Alex Kipman and Julia White. The HoloLens 2.0 aims to fix the technical limitations present in the original HoloLens AR headset. Microsoft had previously confirmed that the next HoloLens will be powered by an AI processor for machine learning. The second generation of the AR headset may deliver improvements in the field of vision including eye tracking, as well as a lighter body for added comfort.
Further, it is also anticipated that Microsoft is also working on several new devices, including a modular Surface Studio and even a folding Surface Centarus. Though, announcements related to these devices might not be a part of the MWC 2019.
Rishabh Software is a specialist in building custom enterprise solutions using Microsoft Technologies. Our Microsoft capability helps companies address business challenges like exponential data growth, critical performance requirements and high usability expectations.


text:
Q: Are there any ways to put AKS cluster nodepool into different fault/update domains together with availability zones? When deploying AKS cluster into different availability zones ("1,2,3" in our case) the vm scaleset is used for default nodepool deployment (not availability set). Everything is pretty fine there, but the problem is - while using the default nodepool scaleset, it is put into 1 fault domains only, and i did not find a way to change that (despite the fact, that the vm scaleset should be deployed into 5 fault/update domains as per documentation):

Why is it so ? How to put the nodepool into default 5 fault/update domains in addition to 3 availability zones (i mean 5 fault/update domains in each of the 3 availability zones)?
P.S. - You can always deploy AKS cluster's nodepool into availabilitySet, and have 5 update/fault domains, but then the availability zones are not available when using the availabilitySet.

A: By reference to this doc: Choosing the right number of fault domains for virtual machine scale set, for the regions that support zonal deployment of virtual machine scale sets and this option is selected, the default value of the fault domain count is 1 for each of the zones.
You can also consider aligning the number of scale set fault domains with the number of Managed Disks fault domains.

redpajama_set_name: RedPajamaStackExchange


Bifiform - means for the normalization of the bowel.
In group membership Bifiform relates to microbial antidiarrheal drugs, probiotics. Probiotics are live microorganisms, the proper use of which allows to settle the balance of intestinal microflora.
One capsule contains at bifiform 10 million bifidobacteria and enterococci, which are placed in special capsules, protecting them from the effects of gastric juice. Just reaching the intestine where pH corresponds to 6, 0-6, 8, Bifiform capsules dissolve, allowing them placed in the bacteria colonize the colon and small intestine. Bifidobacteria and enterococci have the ability to inhibit the growth and reproduction of pathogenic microorganisms by production of acetic and lactic acid.
In bifiform presented bacterial strains with high levels of resistance to antibiotics.
Application bifiform improves the synthesis and absorption of vitamins and promotes enzymatic digestion of complex carbohydrates, fats and proteins.
Reviews bifiform confirm the efficacy of the drug when it is used to normalize intestinal flora, stimulation of correcting violations of the digestive tract, improving nonspecific resistance to various factors.
lactose intolerance, dyspepsia (violation of the stomach), flatulence.
According to the instructions Bifiform adults and children older than two years should be taken twice a day 1 capsule, with the maximum allowable daily dose is 4 capsules. Application bifiform independent of meal times.
Twice a day ½ capsule administered to children between two and six months, and 1 capsule for children aged from six months to two years. Babies are not able to swallow the capsule, the contents are mixed with food. The course usually use bifiform It is 10-21 days. Gastrointestinal disorders, accompanied by acute diarrhea, are treated 2-3 days.
For newborns and young children may use the lactic acid bacteria in the form of an oily solution or a suspension prepared from powders - Baby Bifiform. The composition of the drug are bifidobacteria and streptococci. Baby Bifiform taken once a day in an amount of one dose (0, 5 mL). The course of treatment is 10-20 days.
Reviews bifiform testify not only to the normalization of the bowel after use of the drug, but also to strengthen immunity and improve general health.
The instructions to bifiform negative effects after the drug is not indicated. In a review of bifiform not meet complaints of adverse reactions to the probiotic.
The reason for non-use bifiform may be increased sensitivity to the auxiliary components of the preparation: glucose, yeast extract, syrup bean gum, magnesium stearate, lactulose dry, titanium dioxide, polyethylene glycol, soybean oil, acetyl monoglycerides.
According to the instructions Bifiform should be stored in a dark, dry place where the temperature does not exceed 15 ° C. The drug is considered to be fit within two years from the date of production. Baby Bifiform kept under the same conditions as Bifiform. The suspension Bifiform Baby must be used within two weeks.


The gradient of a graph often represents an important physical quantity. The gradient of a distance time graph is the velocity, and the gradient of a graph of potential energy against distance is the negative of the force acting on a body. Actually, to be completely accurate, the gradient at a point on a distance time graph is the velocity at that time (the time will be read off the horizontal axis), and the force on a body is the negative gradient of the potential energy plotted against distance at a point.
To find the gradient of a graph at a point draw a tangent to the graph and construct a right angled triangle with the base parallel to the horizontal axis and the height parallel to the vertical axis.
The gradient will then be the height dividing by the base, with the proviso that the gradient is positive if the graph is going up from left to right and negative if the graph is going down from left to right.
The height of the triangle above is about 3 -0.8=2.2 and the base is about 6.5-0.1 =6.4 so the gradient is (positive since the graph is going up from left to right).


Located in the coveted Estates lll neighborhood at Las Campanas and set on a quiet cul-de-sac with stunning views of the Sangre de Cristo and Jemez mountains , this 3 bed 4 bath contemporary home designed by the local firm of Hoopes and Associates Architects and currently being built by RayLee Homes brings together elegance and ease of living. Once completed, you will enter through the striking hallway with a portal that separates the master retreat and study from the other parts of the home. Entertaining will be effortless as the dining area flows seamlessly into the spacious kitchen with a large island with a five-burner cooktop and room for informal seating. A large portal with a fireplace off the Great Room offers terrific entertainment options. The split floor plan with 2 bedrooms with ensuite baths offers privacy to guests. Extra amenities include a separate media room/den, insulated windows and a 3-car garage. Near Club Area and Golf Course. Lots of indoor and outdoor areas to enjoy the magical Santa Fe skies at sunrise and sunset.


Stay at Merwehuis Bed and Breakfast offering guesthouse accommodation in Rossmore Johannesburg, South Africa. Business accommodation in Auckland Park.
Situated in the midst of the vibrant community of Auckland Park and Rossmore in Johannesburg, Gauteng, Merwehuis Bed and Breakfast offers a tranquil ambience where you can experience real South African hospitality in a spacious home. The owners made special effort in providing excellent facilities for the physically impaired.
Merwehuis offers 5 double en-suite bedrooms, as well as 2 single en-suite bedrooms. All the rooms have self catering facilities. The layout of the establishment enhances the mobility for people who are wheel chair enabled. Three of the double en-suite bedrooms are fully wheelchair enabled.


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MacNimation White on Orange Set Only Full
A complete set of 149 Icons with a White logo on an Orange Background Round. There is a complementary set also that can be purchased and used as a reverse roll over effect. 3 sizes already so you dont need to resize too much. All of the main Social Media icons provided.
MacNimation White on Maroon Set Only Full
A complete set of 118 Icons with a White logo on a Maroon Background Round. There is a complementary set also that can be purchased and used as a reverse roll over effect.
MacNimation White on Light Brown Set Only Full
A complete set of 118 Icons with a White logo on a Light Brown Background Round. There is a complementary set also that can be purchased and used as a reverse roll over effect.
MacNimation White on Light Blue Set Only Full
A complete set of 118 Icons with a White logo on a Light Blue Background Round. There is a complementary set also that can be purchased and used as a reverse roll over effect.
MacNimation Purple on White Set Only Full
A complete set of 118 Icons with a Purple logo on a White Background Round. There is a complementary set also that can be purchased and used as a reverse roll over effect.
MacNimation Pink on White Set Only Full
A complete set of 118 Icons with a Pink logo on a White Background Round. There is a complementary set also that can be purchased and used as a reverse roll over effect.
MacNimation Orange on White Set Only Full
A complete set of 118 Icons with an Orange logo on a White Background Round. There is a complementary set also that can be purchased and used as a reverse roll over effect.
MacNimation Orange on Blue Set Only Full
A complete set of 118 Icons with an Orange logo on a Blue Background Round. There is a complementary set also that can be purchased and used as a reverse roll over effect.
MacNimation Maroon on White Set Only Full
A complete set of 118 Icons with a Maroon logo on a White Background Round. There is a complementary set also that can be purchased and used as a reverse roll over effect.


This entry was written by Owen Murray, posted on September 21, 2015 at 4:12 am, filed under Photography and tagged Aix-en-Provence, Caen, Charreaux, Chateau, Forcalquier, France, Hautfort, Lisieux, Lyon, Normandie, Paris, Photography, Rhodes, Saint Ouen, Travel. Bookmark the permalink. Follow any comments here with the RSS feed for this post. Post a comment or leave a trackback: Trackback URL.


text:
package extractors.examples

object StableIds {

  sealed trait Action
  object Drink extends Action
  object Eat extends Action
  object Sleep extends Action

  def execute(t: Action) = t match {
    case Drink => "slurp"
    case Eat => "crunch"
    case Sleep => "zzZZz"
  }

  import math.{round, random}

  val Mystery = round(random * 3)

  def guess(n: Long) = n match {
    case Mystery => "Yeepee!"
    case _ => "Missed…"
  }

}

redpajama_set_name: RedPajamaGithub


text:
Antonio Farguhason (Ciudad de Panamá, Panamá, Panamá, 28 de mayo de 1986) es un futbolista panameño. Juega de extremo izquierdo y su equipo actual es el Panamá Viejo FC de la Liga Nacional de Ascenso de Panamá.

Trayectoria
Sporting 89 Temporada 2004*

Cuarta División 18 goles 4 asistencias.

Chorrillo FC Temporada 2006*
Primera División 3 goles.

Sporting 89 Temporada 2007*
Primera División 7 goles.

Plaza Amador Temporada 2008*
Primera División 3 goles.

Orión FC Temporada 2009 - 2012*
Segunda División 8 goles 0 asistencias.

S.D. Panamá Oeste Temporada 2013 - 2014
Tercera División 4 goles 0 asistencias.

San Martín F.C Temporada 2015
Tercera División 12 goles 0 asistencias.

Club Atlético Independiente C.A.I. La Chorrera Temporada 2016
Segunda División 7 goles 6 asistencias.

Panamá Viejo FC Temporada 2017
2 goles 8 asistencias.

Selección nacional
No ha sido convocado.

Palmarés

Títulos nacionales

Distinciones individuales

Enlaces externos

Nacidos en Ciudad de Panamá