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Electrons, Neurotoxins, NAD+, and Mitochondria
Written by Tommy Wood MD, PhD
A very interesting paper posted by the encyclopaedic Rhonda Patrick last week brought a few recent discussions at NBT full-circle. The study is a nice and succinct amalgamation of data from humans showing that endurance exercise produces a shift in the kynurenine pathway, resulting in more kynurenic acid (KYNA) and less quinolinic acid (QUIN).1 The authors say that this has important implications in depression, where exercise has multiple proven benefits, because QUIN is neurotoxic and associated with the neuroinflammation often seen in depression, whereas KYNA is more neuroprotective.
If all of that sounds like a random sciencey word generator, let's step back and mention that these are all metabolites of the amino acid tryptophan (TRP). It's thought that about 95% of TRP goes down the kynurenine pathway with the end product of NAD+. It looks a little something like this:
Tryptophan metabolism through kynurenine and quinolinic acid to NAD+ (adapted from Esquivel et al. Neuropharmacology 2016).
The kynurenine pathway has been the focus of a lot of recent research into neurological diseases because of the fact that QUIN can act as an "excitotoxin" at glutamate receptors, and is associated with neuroinflammation. Enzymes in the first step of the kynurenine pathway are also upregulated during (neuro)inflammation,2 which has made the pathway a potential target for pharmacological intervention in neurological diseases. As usual, if something is bad, the knee-jerk response seems to be to find ways to block it rather than understand why it happens.
When we do a urine organic acids (OAT) test with athletes at NBT, we can actually measure QUIN and KYNA to get an idea of the balance in this pathway in relation to the other major pathway of TRP metabolism, which produces serotonin (and then melatonin). Elevated QUIN is normally attributed to some degree of neuroinflammation. The standard response might therefore be to recommend some anti-inflammatory agents such as curcumin or N-acetylcysteine (NAC). But it's important to remember two things:
Just because QUIN is associated with neuroinflammation does not mean neuroinflammation is present if QUIN is high.
The result tells you nothing about why QUIN is elevated.
The obvious thought would then be to ask "what does QUIN do?", and this is exactly the question I got from Chris. As with most things in biology, some QUIN is good, but a lot of QUIN is bad. Though it could just be a necessary intermediate in NAD+ synthesis, QUIN does seem to have a function in regulating redox state in the cell, particularly through interactions with iron and the Fenton cycle.3 Perhaps it is then not surprising that the balance of metabolites in the kynurenine pathway is intimately linked to cellular redox state.4
The kynurenine pathway therefore becomes another reminder that pretty much everything in biology is driven by the movement of electrons. Though you may not realise it, any time somebody talks about redox state, mitochondrial function, oxidative stress and reactive oxygen species (ROS), or inflammation, they're essentially talking about electrons being where you do (health) or don't (disease) want them to be. And seeing as we love talking about insulin resistance, the function of the insulin receptor is also determined by ROS (none bad, some good, lots also bad).5,6 It's not just about the carbz.
Coming back to QUIN, we see that the enzyme that metabolises the main step from QUIN to NAD+ (QPRTase) is inhibited by elevated oxygen levels, as well as an accumulation of metabolic intermediates, especially those from the Kreb's cycle. When any of those go up, NAD+ production is slowed, and QUIN can accumulate:
Activators and inhibitors of QPRTase (adapted from Esquivel et al. Neuropharmacology 2016).
In the cytoplasm of the cell, oxygen and Kreb's cycle intermediates increase when the mitochondria stop working. Bringing together two branches of thought (i.e. the theories are good but some of it is still speculative), these increases in Kreb's cycle intermediates and cytosolic oxygen may be part of a co-ordinated response. When something (i.e. a pathogen) is present in the body or in a cell, it often affects mitochondrial function, for instance by stealing a nutrient. As a result, certain intermediates in the Kreb's cycle increase because the mitochondria become less able to take the electrons from NADH and FADH2 produced during metabolism. As a result, two things happen:
The mitochondria no longer act as a sink for oxygen, and the oxygen concentration in the cytosol increases. In the oxidative shielding theory, this allows for more ROS to be produced to fight the pathogen.7
The Kreb's cycle intermediates such as citrate and succinate act as messengers between cells, especially cells of the immune system, to help co-ordinate the immune response.8
In this setting, high QUIN is a result of the cell diverting metabolic pathways away from NAD+ production while it deals with the invader. In the modern environment, certain toxic exposures that affect nutrient handling or inhibit mitochondrial function (i.e. phenolic pesticides that alter iron homeostasis) could also have the same effect, and induce this response without a pathogen in sight.9,10
Going back to the initial paper, it could therefore be that endurance exercise is helping to promote mitochondrial flux, which will increase oxygen usage in the mitochondria and reduce the accumulation of specific Kreb's cycle intermediates as they get "used". So a decrease in QUIN relative to KYNA after an endurance race may not (just) be due to less QUIN production. Removing the metabolic brakes will result in more QUIN continuing towards the production of NAD+.
Side step: This metabolic process reminded me of the popular supplement pyrroloquinoline quinone (PQQ), which has a number of potential functions, including modulation of cellular redox state.11 When healthy volunteers are given oral PQQ, overall urinary excretion of Kreb's cycle intermediates decreases. Though it's probably over-simplified in an attempt to sell expensive pills, this drop in accumulated intermediates is thought to be due to increased mitochondrial efficiency. In the same subjects, PQQ supplementation also reduced markers of inflammation (decreased CRP via a reduction in IL-6).
Tying this all together, it seems that inflammation, quinolonic acid, the kynurenine pathway, and production of NAD+ (one of the key regulatory molecules in metabolism) are all directly linked to healthy mitochondria in a happy cellular environment. This is almost certainly why low intracellular NAD+ (or a low NAD+/NADH ratio) is implicated in everything from aging to neurological and autoimmune diseases.12-14
As a result of this, there's a big push to increase NAD+ with supplements, and we've recommended the NAD+ precursors niacin and nicotinamide riboside (NR) to certain clients to help them do that.15 However, this has two caveats:
You still need to ask why NAD+ production has dropped. What's interrupting the pathway from TRP to NAD+ via QUIN? What's driving the destruction of NAD+?16 Probably crappy mitochondrial function, which you need to fix.
The metabolism of NAD+ (and NAD+ precursors such as niacin and NR) is methylation-intensive.15,17 This is one reason why niacin is given to people that get a bad reaction from supplementing with methyl-folate. The niacin chews up the extra methyl groups and you pee them out. As with everything, a reductionist approach to NAD+ (i.e. slamming back large doses of NR) may do more harm than good in some people if you don't know about their other metabolic pathways.*
As Bill Lagakos will tell you, NAD+ production and cycling is also directly linked to how well you look after your circadian biology.
In short, the words are complicated and the pathways are cool, but if you want to live a long life free of inflammation and insulin resistance, you need happy and healthy mitochondria, which means you need to fix your environment, both externally and internally.
*P.S. Creatine synthesis accounts for up to 70% of the use of methyl groups derived from S-adenosylmethionine (SAMe) in humans.18 I therefore have a theory that supplementing with creatine could help balance the demand placed on the methylation system that may occur during supplementation with NAD+ precursors.19 The issue of NAD+ precursors potentially putting a strain on the methylation system is probably also why Thorne have added trimethylglycine (TMG or betaine) to their new NR preparations.
1 Schlittler, M. et al. Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans. American journal of physiology. Cell physiology 310, C836-840, doi:10.1152/ajpcell.00053.2016 (2016).
2 Lovelace, M. D. et al. Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases. Neuropharmacology, doi:10.1016/j.neuropharm.2016.03.024 (2016).
3 Kubicova, L., Hadacek, F. & Chobot, V. Quinolinic acid: neurotoxin or oxidative stress modulator? International journal of molecular sciences 14, 21328-21338, doi:10.3390/ijms141121328 (2013).
4 Gonzalez Esquivel, D. et al. Kynurenine pathway metabolites and enzymes involved in redox reactions. Neuropharmacology, doi:10.1016/j.neuropharm.2016.03.013 (2016).
5 Williams, K. J. & Wu, X. Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward. Atherosclerosis 247, 225-282, doi:10.1016/j.atherosclerosis.2016.02.004 (2016).
6 Pomytkin, I. A. H2O2 Signalling Pathway: A Possible Bridge between Insulin Receptor and Mitochondria. Current neuropharmacology 10, 311-320, doi:10.2174/157015912804143559 (2012).
7 Naviaux, R. K. Oxidative shielding or oxidative stress? The Journal of pharmacology and experimental therapeutics 342, 608-618, doi:10.1124/jpet.112.192120 (2012).
8 O'Neill, L. A. & Pearce, E. J. Immunometabolism governs dendritic cell and macrophage function. The Journal of experimental medicine 213, 15-23, doi:10.1084/jem.20151570 (2016).
9 Caito, S. W. & Aschner, M. Mitochondrial Redox Dysfunction and Environmental Exposures. Antioxidants & redox signaling 23, 578-595, doi:10.1089/ars.2015.6289 (2015).
10 Schreinemachers, D. M. & Ghio, A. J. Effects of Environmental Pollutants on Cellular Iron Homeostasis and Ultimate Links to Human Disease. Environmental health insights 10, 35-43, doi:10.4137/ehi.s36225 (2016).
11 Rucker, R., Chowanadisai, W. & Nakano, M. Potential physiological importance of pyrroloquinoline quinone. Alternative medicine review : a journal of clinical therapeutic 14, 268-277 (2009).
12 Schultz, M. B. & Sinclair, D. A. Why NAD(+) Declines during Aging: It's Destroyed. Cell metabolism 23, 965-966, doi:10.1016/j.cmet.2016.05.022 (2016).
13 Penberthy, W. T. & Tsunoda, I. The importance of NAD in multiple sclerosis. Current pharmaceutical design 15, 64-99 (2009).
14 Kong, S., McBurney, M. W. & Fang, D. Sirtuin 1 in immune regulation and autoimmunity. Immunology and cell biology 90, 6-13, doi:10.1038/icb.2011.102 (2012).
15 Trammell, S. A. J. et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications 7, 12948, doi:10.1038/ncomms12948 http://www.nature.com/articles/ncomms12948 - supplementary-information (2016).
16 Camacho-Pereira, J. et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell metabolism 23, 1127-1139, doi:10.1016/j.cmet.2016.05.006 (2016).
17 Quinn, G. P. & Greengard, P. The pathway for the biosynthesis of N1-Methyl-4-pyridone-3-carboxamide. Archives of Biochemistry and Biophysics 115, 146-152, doi:http://dx.doi.org/10.1016/S0003-9861(66)81050-0 (1966).
18 Stead, L. M., Brosnan, J. T., Brosnan, M. E., Vance, D. E. & Jacobs, R. L. Is it time to reevaluate methyl balance in humans? The American journal of clinical nutrition 83, 5-10 (2006).
19 Stead, L. M., Au, K. P., Jacobs, R. L., Brosnan, M. E. & Brosnan, J. T. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. American journal of physiology. Endocrinology and metabolism 281, E1095-1100 (2001).
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Diet Experts Don't Know What They're Doing – Public Reacts


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Don Cayo: Scots want the world to know they produce much more than scotch
Don Cayo, Vancouver Sun columnist 06.14.2013
Dolly the sheep was the world's first cloned mammal and has come to represent Scotland, along with those wee drams, of course.
Getty Images / Getty Images
It's okay to stereotypically link scotch and Scotland in your mind, says Lena Wilson, the CEO of Scottish Enterprise, who travels the world — including B.C. this week — to promote trade and investment.
After all, whisky exports are worth nearly $1.3 billion a year to a country that's an eighth the size of B.C. and boasts a population 20 per cent larger.
But if the mention of Scotland makes you think of sheep, another iconic image from the land of bonny braes, Wilson wants you to picture an image of Dolly. Created from cells taken from a "mother" ewe's mammary gland and named for American entertainer Dolly Parton, this ordinary-looking ovine was the world's first cloned mammal and very much a product of Scotland. Even today, nearly two decades later, she symbolizes her country's expertise in high-end, cutting-edge research.
This modern version of smart, savvy Scotland — not laddies with their kilts or lassies with their tartan tams — is the image Wilson is in Canada to sell.
"We're talking about knowledge and expertise," she told me when we chatted in advance of the event that brought her to Vancouver — the launch last evening of ScotCanBC, the Scottish Canadian Business Association of B.C.(ScotCanBC.org) "We're talking about financial transactions, knowledge-based collaborations that lead to foreign direct investment and that play to Scotland's strengths as a high-knowledge, high-value place to do business."
The Scottish economy has been moving in a focused way in this direction for at least four decades, and with notable success, although not a lot international fanfare.
"It's all about being really careful about the niche that we're in," Wilson said.
"Scotland isn't all things to all people. We're not a low-cost place. But where there's a niche where we can be first or second in the world, that's where we want to be."
Thus her bid to forge links with B.C. isn't about our old economy. Our resource-dependent export industries may be successors to the two-century-old fur trade that attracted B.C.'s first Scots: men who, with those who followed over the years, are the ancestors of 20 per cent of us who live here today. But the reality is that we aren't likely to sell much lumber or minerals or gas to distant cousins who stayed in the old country.
The trade and investment links Wilson seeks to foster are in things that don't need to move halfway around the world in ships. The fields are those such as life sciences, renewable energy and some of the creative industries, and often as not "products" will be knowledge, research, collaboration, investment capital and the like.
There are some links along this line already, but they are — in the broad scheme of things — quite trivial. Scots sell Canadians only about $500 million in goods and services a year, and we export products worth only $300 million and change.
This is well under 0.1 per cent of Canada's total exports but Wilson's not daunted.
"To me, this means more opportunity," she said. "I want that $500 million to be $1 billion. To be $1.5 billion. To be $2 billion."
Nor does she think the possibility of Scotland separating from the U.K. will spook Canadian companies, even though many Canadians remember economic chill felt when Quebec separation seemed an all-too-possible outcome of referendums in 1980 and 1995. Scotland, now governed by a nationalist party, is facing an independence referendum in September of next year.
Wilson carefully avoids taking sides, but she notes the government's oft-made point that Scotland is a leading location for foreign direct investment, and it wouldn't be if international firms were worried about the outcome.
As well, the nationalist government strongly favours the European Union. If the referendum wins, this could mean Canadian firms will get privileged access thanks to the comprehensive trade agreement between Canada and the EU that's still in the works.
dcayo@vancouversun.com

redpajama_set_name: RedPajamaCommonCrawl


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An Online Community Framework from a Cool Vendor
By Barb Mosher Zinck | Mar 27, 2009
CHANNEL: Web Development
It's going to be an interesting Web 2.0 conference in San Francisco next week. Among the announcements, you can expect to hear from IGLOO Software. At the conference they will be unveiling their new framework for building community solutions.
The new Online Community Platform has four primary components to it including:
Theme Manager: Control the brand of your community through layouts and design.
Global Configuration Panel: Turn applications on and off
Widget Manager: Drag and drop capability as well as create and configure custom built widgets
Open API's: Integration with other applications and solutions including CRM, ERP and cloud-based solutions such as Salesforce.com and Google Gadgets.
IGLOO is banking on their Open API's and widget based architecture to push their Online Community Platform to the forefront as it will enable organizations to get a community up and running quickly. Integration with key third party content and applications will also contribute to its ability to deliver. After all, it's clear that a community that operates in a silo does not add advantage to an organization.
"The new platform is all about flexibility and modular applications that enable interconnected networks of teams and individuals within an organization to work together more efficiently and effectively," says David Shak, VP of Platform Development for IGLOO Inc.
Want to see how easy their framework is to use? Watch this video or read the presentation.
Understanding the Differences Between Microservices, Monoliths, SOA and APIs
Tags communities, igloo software, open api, web development, widgets


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Home › News › Northern Ireland
BBC NI pulls plug on Jackie Fullerton after 37 years behind the microphone
Jackie Fullerton says he's thankful for the broadcasting career he has enjoyed
Looking good: Jackie Fullerton on the golf course
Jackie presents the sport on TV earlier in his career
Sports presenter and commentator Jackie Fullerton
Press Eye - Belfast - Northern Ireland - 4th May 2015 - NIFWA Annual Dinner 2015 sponsored by BT Sport at the Ramada Hotel Belfast. Jackie Fullerton with the BT Sport Young Player of Year to Gavin Whyte from Crusaders Picture by Kelvin Boyes / Press Eye.
Jackie Fullerton with wife Linda
Connections: Brendan Rodgers talks to Jackie Fullerton
Double take: actor Conleth Hill as legendary football commentator Jackie Fullerton in the film Shooting for Socrates
Legendary football commentator Jackie Fullerton
Paddy Hopkirk and Jackie Fullerton
Press Eye Belfast Northern Ireland - 26th January 2014 - Picture by Kelvin Boyes / Press Eye. 2014 Belfast Telegraph Sports Awards sponsored by Linwoods at the Ramada Hotel, Belfast? Claire McCollum and Jackie Fullerton on stage
David Healey, Claire McCollum Jackie Fullerton
Jackie Fullerton and Trevor Ringland, Ballymena Champions, with Mayor of Ballymena Audrey Wales
Exclusive by John Laverty
Jackie Fullerton will be at next summer's European Championships in France... as an interested spectator.
https://www.belfasttelegraph.co.uk/news/northern-ireland/bbc-ni-pulls-plug-on-jackie-fullerton-after-37-years-behind-the-microphone-34178134.html
https://www.belfasttelegraph.co.uk/incoming/article34178420.ece/f556b/AUTOCROP/h342/ss%20Eye%20Ltd%20N_2.jpg
His days of commentating on Northern Ireland international matches are over, 37 years after they began.
And when Michael O'Neill's men run out at Windsor Park next Friday night for a pre-Euro 2016 warm-up game, a man nearly half Jackie's age will be behind the BBC Northern Ireland mic.
Joel Taggart has got the nod for the visit of Latvia - and the veteran he replaces was one of the first to congratulate him.
"It's the right time for a younger man to take up the reins," says broadcasting legend Jackie, who will turn 73 just before the end of this current football season.
"I have to move on, the BBC have to move on. I've loved commentating on the big Northern Ireland games, loved every minute of it, even loved the pressure associated with it, but I'm not getting any younger.
"I'm 72 now and I'm due to have a new hip fitted early in the new year. The plan is to get over to France, sit back, relax and see Northern Ireland compete out there."
Ballymena man Jackie, who works as a freelance these days, says he will continue to do "bits and pieces" for local BBC before finally calling it a day.
He reckons he's done live commentary on over 100 Northern Ireland matches since his 'debut' - for Ulster Television - back in September 1978.
"That was the Republic versus our boys in a Euro qualifier at Lansdowne Road; the first time the 'two Irelands' had met each other", he recalls.
"It wasn't much of a game, finishing 0-0, but I thought I did all right."
John Alexander 'Jackie' Fullerton, MBE, who is renowned for his unflustered delivery and meticulous pre-match research, joined the BBC in 1992 after 19 years as a presenter with the corporation's rivals.
The popular father-of-three was the local Beeb's sports anchor and number one football commentator until his 'annus horribilis' of 2004 when he was controversially removed from his regular role on the flagship Newsline programme and underwent triple heart by-pass surgery.
But he returned to commentating in 2005, although the live Northern Ireland commentaries were curtailed two years later when the Irish FA signed an exclusive deal with Sky, restricting the BBC to highlights packages.
Next Friday night would have been a comeback of sorts for Jackie but a BBC Northern Ireland statement to the Belfast Telegraph, in which they turned down the opportunity to name the match commentator, suggested a change was afoot.
There are, however, no regrets, just highlights. Ironically, two of those have coincided with Northern Ireland defeats. "Commenting on the England match in 1979 (European Championship qualifier, 4-0 to England) was a special moment for me," he says.
"As a young footballer (he played for Ballymena United, Cliftonville, Derry City and Crusaders) I, like many others, dreamed of playing at Wembley. It didn't happen, but commentating was the next best thing."
Jackie, who married his beloved Linda 47 years ago, was also behind the mic when Northern Ireland's amazing 1982 World Cup adventure came to an end when they lost 4-1 to France in the Spanish capital Madrid.
"It was our wee country at the World Cup finals; it doesn't get any better than that," he says.
"And now, after nearly 30 years, we're back at a major championship. Exciting times lie ahead."
The best moments, invariably, involve Northern Ireland's record goalscorer David Healy; the brilliant hat-trick against Spain (Windsor Park, 2006) and the all-time high - that winning goal against England in Belfast a year earlier.
"I do have one regret about that," concedes Jackie.
"I flew out to Majorca on holiday the following day; looking back, it would have been great to hang around and soak up the post-match atmosphere and excitement.
"You don't witness something like that every day."
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Boris Johnson's team plays down claim he plans to prorogue Parliament
By Harriet Line Boris Johnson's campaign aides have sought to play down reports that they are considering plans to prorogue Parliament in late October - a move which could prevent MPs stopping a no-deal Brexit.
Stories from Battle of Bogside to form new exhibit 50 years on
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Roman Savosin
Thread starter The Finn
The Finn
Roman Andreyevich Savosin (Russian: Роман Андреевич Савосин, born 4 December 1999 in Moscow, Russia) is a Russian figure skater. He is the 2019 Junior World silver medalist, the winner of the 2016 CS Tallinn Trophy, the 2016 CS Ondrej Nepela Memorial bronze medalist, and 2016 JGP France champion.
ISU bio
http://www.isuresults.com/bios/isufs00034437.htm
Russian bio, archived July 2019
https://web.archive.org/web/20190723192518/https://fskate.ru/skaters/1861.html
Tracings profile
http://tracings.net/savo-roma.html
https://en.wikipedia.org/wiki/Roman_Savosin
https://www.instagram.com/roman_savosin04/
Personal Best Score
new ISU Scoring System
http://www.isuresults.com/bios/isufs_pb_00034437.htm
Type Score Competition
Personal Best Total Score 229.28 ISU World Junior Championships 2019
Personal Best Score Short Program 78.33 ISU World Junior Championships 2019
Personal Best Score Free Skating 150.95 ISU World Junior Championships 2019
Programs & Videos
SP: "Bella Ciao" performed by Andre Rieu; choreo by Stanislav Shasherin
FS: "Réquiem" by Vicente Amigo; choreo by Stanislav Shasherin
SP: "Dance of the Bessarabian Gypsies" by S. Galperin; choreo by Viacheslav Kalinin, Stanislav Shasherin
FS: Violin Concerto by Petr I. Tchaikovski; choreo by Viacheslav Kalinin, Stanislav Shasherin
2019 Skate America (geoblocked in US)
SP https://youtu.be/FtuOr1bMjZI
FP https://youtu.be/7ly2JQ1qOBw
2019 Russian Test skate event.
SP https://www.youtube.com/watch?v=yvlUIxl2_TI
FS https://www.youtube.com/watch?v=36JZiiUlIVo
SP: "Granada" by Agustin Lara; choreo by A. Kazakova, V. Kalinin, S. Shasherin
FS: Piano Concerto No 2 by Sergei Rachmaninov, performed by David Garrett; choreo by A. Kazakova, V. Kalinin, S. Shasherin
2019 Junior World Championships
SP: https://www.youtube.com/watch?v=dzo81na5-VI
FS: https://www.youtube.com/watch?v=jkG2rES52Mw
Victory Ceremony: https://www.youtube.com/watch?v=d7ZE_n532Bs
2018 JGP Bratislava
SP: https://www.youtube.com/watch?v=y5Zk7_QtSHk.
FS: https://www.youtube.com/watch?v=xmKK43_ABHI
2018 JGP Linz
SP: https://www.youtube.com/watch?v=gThshjI0DhU
FS: https://www.youtube.com/watch?v=BBYZC72_e4k
SP: Music Selection by Hugues Le Bars; choreo by N. Bestemianova, I. Bobrin, A. Kazakova
FS: Toccata and Fugue by Johann Sebastian Bach; choreo by N. Bestemianova, I. Bobrin, A. Kazakova
SP: https://www.youtube.com/watch?v=QvG8LHyQGSw
FS: https://www.youtube.com/watch?v=7k8WqmkkLHc
2017 JGP Riga
SP: https://www.youtube.com/watch?v=ucvlA10Aayw
FS: https://www.youtube.com/watch?v=7vbf_X8q9U0
2017 JGP Cup of Brisbane
SP: https://www.youtube.com/watch?v=RTY7C1FtnsQ
FS: https://www.youtube.com/watch?v=qVJiFPeetds
SP: Bella Ciao by André Rieu and the Johann Strauss Orchestra; choreo by Anastasia Kazakova, V. Kalinin, S. Shasherin
FS: Smuga Cienia by Wojciech; choreo by Anastasia Kazakova, V. Kalinin, S. Shasherin
2017 Russian Junior Nationals
SP: https://www.youtube.com/watch?v=W9lrUkrxhY8
FS: https://www.youtube.com/watch?v=W9lrUkrxhY8
2016 JGP France
SP: https://www.youtube.com/watch?v=v0MILbVEf0Y
FS: https://www.youtube.com/watch?v=FSKd1Tpdo28
2016 JGP Czech Skate
SP: https://www.youtube.com/watch?v=Qqg0r4AaNAI
FS: https://www.youtube.com/watch?v=erY7N7paL9w
SP: "Il Mirto e la Rosa" by Alessandro Safina; choreo by Viacheslav Kalinin
FS: Adriano Celentano Medley; choreo by Viacheslav Kalinin
2016 Junior Championships of Russia
FS: https://www.youtube.com/watch?v=bugIMA6fsTE
2015 Second Stage Russian Cup
FS: https://www.youtube.com/watch?v=1aBrVu2SfSE
2014 First Stage Russian Cup
SP: https://www.youtube.com/watch?v=eLr_D3lDpjY
FS: https://www.youtube.com/watch?v=Sql4hKi8m2U
2014 Russian Junior Championships
2013 Moscow Open Championships
FS: https://www.youtube.com/watch?v=5WlVBkGxX_s
2013 Championship of Russia, Elder Age
FS: https://www.youtube.com/watch?v=y69JN5JY-SE
SP: https://www.youtube.com/watch?v=BY8oXOEm-XQ
FS: https://www.youtube.com/watch?v=sR6TCsXW0vU
SP: https://www.youtube.com/watch?v=thnUnAbYB3Y
2012 Championship of Russia, Younger Age
FS: https://www.youtube.com/watch?v=gvKcqhegcj4
2011 Final of the Cup of St. Petersburg
FS: https://www.youtube.com/watch?v=o-zm50JDE0k
Competitive History
Competition SP LP Final
2021 Russian Cup Final 4 (87.36) 8 (147.53) 7 (234.89)
2021 Cup of Russia 8 (82.35) 8 (167.72) 8 (250.07)
2019 Skate America 12 (57.92) 12 (124.24 12 (182.16)
2019 World Junior Championships 6 (78.33) 1 (150.95) 2 (229.28)
2019 Russian Junior Championships 7 (78.71) 3 (150.81) 3 (229.52)
2019 Russian Championships 9 (70.71) 13 (129.19) 12 (199.90)
2018 CS Tallinn Trophy 4 (71.50) 5 (133.74) 5 (205.24)
2018 Russian Cup III 2 (66.40) 1 (142.92) 2 (209.32)
2018 Russian Cup II 3 (78.19) 2 (166.71) 2 (244.90)
2018 JGP Cup of Austria 4 (71.41) 3 (119.53) 3 (211.10)
2018 JGP Bratislava 4 (67.10) 7 (122.76) 5 (189.86)
2018 World Junior Championships 12 (65.36) 5 (142.55) 5 (207.91)
2017 CS Warsaw Cup 4 (64.93) 4 (132.22) 4 (197.15)
2017 Russian Cup IV 1 (84.20) 2 (166.71) 2 (224.33)
2017 JGP Riga Cup 3 (63.95) 4 (123.59) 4 (187.54)
2017 JGP Brisbane 3 (68.68) 3 (127.57) 2 (196.20)
2017 Russian Junior Championships 4 (77.57) 10 (134.73) 8 (212.30)
2016-17 Junior Grand Prix Final 3 (72.98) 4 (139.41) 4 (212.39)
2016 CS Ondrej Nepela Memorial 5 (68.10) 2 (154.27) 3 (222.37)
2016 Competition for the prizes of FFCC Moscow - - 1 (234.87)
2016 JGP Czech Skate 3 (72.90) 3 (134.74) 3 (207.64)
2016 JGP St. Gervais 2 (67.44) 2 (130.84) 1 (198.28)
2016 Spartakiade of the Youth of Russia 3 (75.16) 3 (146.90) 2 (222.06)
2016 World Junior Championships 13 (64.00) 14 (117.65) 14 (181.65)
2016 Russian Junior National Championships 3 (71.57) 4 (140.82) 3 (207.40)
2016 Russian Cup Final.(Junior) 1 (75.31) 1 ( 142.98) 1 (218.29)
2015 Junior NRW Trophy 1 (57.80) 1 (111.83) 1 (169.50)
2015 Junior Russia Cup IV 3 (63.25) 6 (123.20) 5 (186.45)
2015 Junior Russia Cup II 1 (69.17) 1 (134.81) 1 (203.98)
2015 Open Championships of Moscow (Junior) - - 7 (184.68)
2015 Championships of Russia, Elder Age (Junior) 10 (55.70) 6 (122.15) 8 (178.85)
2015 Junior Russia Cup Final 5 (61.27) 6 (109.63) 6 (170.90)
2015 Championships of Moscow, Elder Age (Junior) - - 7 (178.55)
2014 N.A.Panin Memorial 6 (60.36) 3 (124.99) 3 (185.35)
2014 Junior Russia Cup I 9 (55.82) 11 (101.55) 10 (157.37)
2014 Open Championships of Moscow - - 8 (142.84)
2014 Junior Russian Cup Final - - 9 (261.89)
2014 Russian Junior National Championships 13 (58.25) 10 (115.64) 12 (173.89)
2013 Junior Russian Cup II 4 (61.54) 6 (114.18) 6 (175.72)
2013 Junior Russian Cup I 1 (63.52) 5 (113.20) 3 (176.72)
2013 Championships of Russia, Elder Age (Junior) - - 5 (171.33)
2013 Junior Russia Cup Final 10 (58.60) 6 (122.31) 6 (169.33)
2012 Russia Cup V 5 (59.60) 6 (110.18) 5 (169.78)
2012 Russia Cup II 6 (57.16) 6 (119.01) 6 (176.17)
2012 Junior Russia Cup I 3 61.69) 6 (111.33) 6 (173.02)
2012 Rooster Cup (Adv. Nov.) 3 (40.17) 4 (68.11) 4 (108.28)
2012 Championships of Russia, Younger Age (Elder Age ) - - 4 (224.84)
2012 Championships of Moscow, Younger Age (Elder Age ) - - 3 (204.25)
2012 Competition for the prizes of E.A. Tchaikovsky (Boys 1) - - 1 (164.00)
2011 S. Volkov Memorial (Elder Age) - - 1 170.97)
2011 Russia Cup IV 14 (42.29) 13 (94.28) 13 (136.57)
2011 A.N. Mishin Cup - - 4 (146.79)
2011 Junior Russia Cup III 9 (48.12) 9 (101.91) 9 (150.03)
2011 Competition for the prizes of the President of the FFCC of Moscow (Junior) - - 1 (153.83)
2011 Junior Russia Cup I 7 (44.27) 5 (104.23) 7 (148.50)
2011 Open Championships of Moscow (Junior) - - 10 (129.49)
2011 Final of the Cup of Saint Petersburg (Junior) - - 4 (151.00)
2011 Championships of Russia, Younger Age (Elder Age) - - 14 (150.92)
2011 Championships of Moscow, Elder Age (Junior) - - 14 (129.27)
2011 Championships of Moscow, Younger Age (Elder Age) - - 7 (168.39)
2010 S. Volkov Memorial (Elder Age) - - 5 (121.29)
2010 Competition for the prizes of the President of the FFCC of Moscow (Junior) - - - 11 (123.22)
2010 Championships of Russia, Younger Age (Younger Age) - - 12 (141.73)
2010 Championships of Moscow, Younger Age (Younger Age) - - 4 (126.48)
2009 S. Volkov Memorial (Younger Age) - - 4 (93.82)
2009 Competition for the prizes of the President of the FFCC of Moscow (Younger Age) - - 3 (101.39)
Golden Skate Interviews , Articles, and Threads
July 2019 Interview - "Russia's Roman Savosin eager to debut at the senior Grand Prix"
Goldenskate https://www.goldenskate.com/2019/07/roman-savosin/
Discussion thread https://www.goldenskate.com/forum/showthread.php?81398
Other Interviews , Articles, and Fluffs
Roman Savosin (video interview): "I trust my coaches. I'm not going to move ."
Google translation link, video of interview[/URL
June 2019 - Moscow Figure Skater magazine
[URL]http://ffkm.ru/images/mf/Figurist_1_2019.pdf
Translation by Google and RemyRose
https://www.goldenskate.com/forum/s...oman-Savosin&p=2405375&viewfull=1#post2405375
Translation of an interview with his coaches from the same magazine
https://www.goldenskate.com/forum/t...7331-a298c9359c00f62e8ec0abda0d43b4c5e05fb233
August 2018 Interview
https://www.youtube.com/watch?v=cIQnnXBYir0
From the original Post
Since he will most likely skate at the JGPF this season I think he deserve a thread here.
I will put this one here also.
The Finn said:
Things looks pretty good for Savosin indeed. In theory he could still end up in 7th on the standings but that is highly unlikely. Once Dima (or someone else) wins both events Savosin will secure his place at the final. The only way Savosin might not make it is if there will be 7 different event winners and they all have similar placement, 1st and 2nd or 1st and 3rd like Savosin.
Roman will make his international senior debut at the Ondrej Nepela Memorial.
Roman had an excellent Challenger Series debut and he even got a medal, bronze. He also broke his PB which is now 222.37 points. By the way his TES in FS was by far the best of the competition 86.57 but in PCS he lost to Voronov about 12 points. Roman landed both 4T and 4S.
Ondrej Nepela Memorial
SP https://www.youtube.com/watch?v=wlkq03-QSrw
FS https://www.youtube.com/watch?v=YjDLjEMTvwg
Match Penalty
nice. never though he had quads already !!!
sneakers said:
He already had the 4T which he landed at his first JGP event for example but the 4S is new as far as I know.
Roman has skated a great FS at a recent competition in Moscow. He landed every big jumps clean with positive GOE including 4T, 4S, 3A+3T and 3A. His TES was above 91 points. His SP wasn't clean, he only got 65 points from his SP. No videos at the moment but protocols can be found in here.
http://ffkm.ru/images/files/016-17/2016-10-27_Prizy_FFKM/Protokol_Prizy_FFKM_2016.pdf
Roman did good today. He scored 77.57 points in his SP at the Junior Nationals. He is 4th after SP
SP https://www.youtube.com/watch?v=W9lrUkrxhY8
Lana05
Final Flight
https://www.youtube.com/watch?v=z6jBHdpeyks His FS
It looks like Roman has the same kind of strategy than what he had last year - to compete as early as possible. Last year he skated at the 1st and 2nd JGP event and now he has been assigned to the 1st and 3rd event.
Well, not his best programs but 2nd placement was a pretty good outcome.
JGP AUS
SP https://www.youtube.com/watch?v=RTY7C1FtnsQ
FS https://www.youtube.com/watch?v=qVJiFPeetds
It seems Roman will stay in juniors since he is one the Russia's entries in JGP Slovakia.
This season will be his last junior eligible season.
RemyRose
Yeah, it was kinda obvious when he didn't get any senior Grand Prix events and he was guaranteed one :think: Guess he wants to try and get a GPF/Jr Worlds medal. Or the Fed doesn't think the new crop of juniors are ready (no quads, unstable or no 3axel) so they kept him in juniors :confused2:
In any event, good luck to him!
LadyB
I like him a lot, wishing him all the best. I hope he does well and gets two placements at JGP.
LadyB said:
And will make it to the JGP Final.
RemyRose said:
Guess he wants to try and get a GPF/Jr Worlds medal. Or the Fed doesn't think the new crop of juniors are ready (no quads, unstable or no 3axel) so they kept him in juniors :confused2:
I think it was probably a good decision to stay in juniors. He has been 4th at the JGP Final and 5th at the Junior Worlds. So, the medals haven't been far away and who knows maybe he will get some big medals this season.
I hope he works on getting positive GOE out of most of his elements and level 4s on all spins. That World free is an example. He would have medaled if he had all level 4s on spins and about 1/2 the positive GOEs that Danielian got even with the flip error or he could have just landed the flip. He was so close to that bronze.
2018/19 programs
SP Granada by Agustin Lara
FP Piano Concerto No 2 by Sergei Rachmaninov, performed by David Garrett
New video interview.
He'll be at JGP in Bratislava which start tomorrow! Good luck, Roman :hap85:
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dorispulaski
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Gleb Lutfullin
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Sihyeong Lee
Lucas Tsuyoshi Honda
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Weasel is the lieutenant of the Mafia in the 2003 incarnation of the animated TV series Teenage Mutant Ninja Turtles.
He was voiced by Michael Sinterniklaas.
He lead a group of mobsters to break into Tyler's house and kidnapped Tyler and his mom after Tyler's mom had a tape that contains enough info to put a local crime boss behind bars. Since Tyler's mom is a reporter, she plans to use the tape to become famous and rich. Weasel and his men planned to rub them out so they haul them into a limo but Tyler's mom gave the tape to her son and told him to run. Tyler kicked Weasel in the shin and ran away. Weasel and his men found Tyler hiding in the dumpster but Raph interfered and beats Weasel's men. Raph agrees to help the kid and they set off for the warehouse where the mobsters are holding Tyler's Mom. Before they get to the warehouse, Raph and Tyler are jumped by a group of mobsters lead by Weasel. During the fight, Weasel throws a flash grenade and Raphael is blinded. They manage to elude the gangsters, and break into the warehouse and confront the mobsters. No sooner do Raph and Tyler enter the building then they're meet by Weasel and his cronies. The gangster, knowing Raph has been blinded, thanks the Turtle for bringing Tyler right into their arms. Soon, the huge mob boss arrives, removes his coat and attacks Raphael. As the thug move in, Tyler starts shouting directions to Raph. The boss orders the boy to be silenced, and Weasel grabs Tyler and covers his mouth. Fortunately Tyler is able to bite Weasel's hand and free himself. Quickly shouting out instructions that allow Raphael to win the fight against the criminal leader. Tyler then grabs Raph's hand and leads him behind some crates. The child tells the ninja to push over the boxes, which Raphael does - creating a huge roadblock that gives the pair time to complete their mission.
The mobsters dig through the rubble. Raph rubs his eyes and discovers that his sight has returned. The ninja moves around the fallen debris and sneaks up behind Weasel, tapping the annoying crook on the shoulder. The gangster turns and taunts the ninja, unaware that he can now see. Raph comments on the thug's ugly tie - and the villain realizes - too late - that his enemy is no longer blinded. Raphael grabs Weasel by the coat lapels and tosses him into the fallen crates and then departs.


Norwegian fish gratin is kind of our weird take on mac and cheese. Originally potatoes were used, but sometime after macaroni was introduced to Norwegians in the early 1900's, we switched over.
Another weird thing is the use of curry powder, which isn't always used but it's not uncommon in some Norwegian fish dishes. I learned this recipe from my father who always uses a lot of curry powder.
This makes for a pretty bizarre combination of ingredients, a kinda fusion of Norwegian, Italian and Indian cuisine, but ever since I was a kid this has been one of my favorite dishes. Fish gratin is actually so common here in Norway that every grocery store has at least 2 or 3 different variants of it in the frozen produce isle, right next to the frozen pizzas and such. Many of them are not bad at all, but needless they don't come close to a good home made one.
Step 2 Bring a large saucepan filled with water to a boil. Turn down the heat so it is warm but not boiling. Salt the water heavily (2 tsp), and stir. Put in the fish and leave until cooked through. 10-20 minutes depending on if you are using frozen or fresh fish.
Step 3 In another pan, boil the macaroni.
Step 4 Remove the fish from the water, and mash with a fork. Some people like bigger chunks of fish and some like smaller, so here it is up to you how much you want to mash it.
Step 5 Melt the butter in a small saucepan over medium heat, stir until smooth and cook for a few minutes. Add the milk little by little and bring to a boil. Add the curry powder, nutmeg, and bouillon and cook for 5 minutes. Season with salt and pepper to taste.
Step 6 Mix the fish, macaroni and bechamel sauce in a bowl. Transfer to a casserole and cover with breadcrumbs. Place in oven, and cook for 30 minutes or until golden.
Step 7 Cook the bacon in a frying pan.
Step 8 Serve the fish gratin with the bacon, a wedge of lemon and a few sprigs of dill.


believe that the first wine caves were reported in the Roman catacombs and certain areas of Iran.
they actually serve quite a functional purpose.
What is the purpose of a wine cave?
compared to the cooling and heating costs of a warehouse.
accidentally turning into very expensive salad dressing.
exposure to the damaging light that can impact its flavor.
perfect environment to ensure the highest level of quality.
One of the best way to get to know Yonah Mountain Vineyards is through our wine cave tour and tasting experience. We'll take you on a 90-minute walking tour of our vineyards and wine caves, all while sampling our very own wines. These are the only known wine caves in Georgia and are an incredible feat of engineering and wine-making alike. This is a great day-trip in Georgia if you've ever wanted to know more about Georgia and wineries in general.


text:
Robotics and Authonomus Devices
Medical and Pharmacutical
Oil and Petrolium
The insurance company has numerous initiatives in place to employ technology and leverage data as a transformation vehicle for business processes and services.
For example, one of the current initiatives launched by the company allows customers to take photographs and videos from collisions and transfer them directly to the company data lake. In this scenario, claims adjusters do not have to travel to take photographs, while advanced analytics and AI are employed for claims resolution. This initiative cuts costs for business, while allowing customers to get paid quicker.
While this initiative is undoubtedly beneficial to both the business and its customers, measures must be taken to ensure customer's privacy. Provided information may contain personal and sensitive data (e.g., people's photographs, license plates, photographs of documents, videos from on-dash cameras and surveillance cameras, etc.).
Company allows customers to perform encryption on their edge devices using the AltaStata, so that transmitted and stored images, documents, and videos remain secure from both external and internal threats. Moreover, AltaStata solution provides secure sharing of sensitive encrypted data with partners (e.g., claims adjusters and other entities) and secure ML/AI processing of this unstructured encrypted data. Furthermore, AltaStata method meets GDPR, HIPAA, FISMA, California Privacy Act, and other regulatory requirements for data protection.
The ML/AI can run at the cloud as well as at the company data center to access the encrypted data lake.
Financial Service Company
Financial service institutions nowadays extract their data sources into raw data format stored in data lakes. This gives users freedom to transform raw data at a later time, once they found valuable or innovative use for it. Some of these uses only become apparent when users are able analyze raw information in all its glorious detail.
To ensure security and compliance for data stored at rest, the organizations use applications which tokenize sensitive data, e.g., customers' SSNs or credit cards numbers. Otherwise, system administrators and some users have excessive privileges to access sensitive data.
The tokenizing process requires careful analysis and replacement of raw data, which is time-consuming and has potential for many kinds of mistakes. To make raw data available for further usage, tokens need to be replaced with the original sensitive data, which, once again, is a time-consuming process. This approach involves a lot of resources, is costly, and can become a nightmare for the large organizations' data lakes support departments. Tokenizing of images and videos is almost impossible.
AltaStata transparently ensures data lakes' security for such organizations. Instead of storing data as plain text, while tokenizing sensitive parts, data owners use AltaStata toolkit to store fully encrypted files and share access with particular users and programs. The organizations' system administrators and CISOs control user access to the data. However, they do not constitute an insider threat, as they cannot access the encrypted data. The data is available to regulators' and auditors' access for compliances verifications.
Even if credentials for some users are compromised, it will not create a massive data breach, as AltaStata restricts excessive privileges by enabling each user to access only his or her data.
AltaStata enables running fast ML/AI parallel processing of encrypted data to help protect against fraud and money laundering. AltaStata's way of data encryption does not impact data access performance and does not require organizations to change their business processes as it supports standard data lakes APIs.
AltaStata supports organizations' multi-cloud strategy by protecting sensitive data lakes in AWS, Azure and Google. In addition, AltaStata cuts organizations' cloud storage costs by compressing the raw data.
Autonomous Devices
The military drone or another autonomous IoT device stores a video/data stream in the cloud using AltaStata SDK. Human end users, as well as programs, can watch, process, and analyze encrypted video, data, messaging streams, sensor feeds through AltaStata data lakes in near real time, while they are still being recorded/transmitted.
Data analysis using ML/AI for HealthTech
BioInformatics company in Europe collects personal genomic data from all parts of the world at the AWS cloud data lake and provides the platform for researchers to perform ML / AI analytics of these data.
Using AltaStata the company is able to adhere to GDPR requirements for personal data protection.
Through the AltaStata implementation of Hadoop data lake a cluster of Spark machines transparently performs fast parallel processing of partitions of encrypted genomes. The same approach works for the entire ecosystem of ML/AI tools, including Hadoop, Impala, Tez, Presto, and more.
In addition to Hadoop data lake, AltaStata provides a Java/Scala/Python client library, which supports files versions, sharing, etc.
©2020 by AltaStata.


Social media platforms, such as Twitter, are a staple of the modern world and facilitate communication between people from all over the globe. Here, Raul Cordoba, MD, PhD, of Fundacion Jimenez Diaz University Hospital, Madrid, Spain, outlines the benefits of using social media as a hematologist, for networking with and getting second opinions from fellow professionals. This interview was recorded at the American Society of Hematology (ASH) 2017 Annual Meeting and Exposition, held in Atlanta, GA.


text:
Het Rozenknop-ei (Engels: Rosebud Egg) is een van de ongeveer vijftig paaseieren die de beroemde juwelier Peter Carl Fabergé maakte in opdracht van de Russische tsaren.

Na de dood van Alexander III volgde zijn zoon Nicolaas II hem op. Hij trouwde eind 1894 met Alix van Hessen-Darmstadt, die daarna de naam Alexandra Fjodorovna aannam en zo tsarina werd. Het ei was een geschenk aan haar en deed haar denken aan de rozentuin die ze had in Darmstadt. Het ei is eigendom van verzamelaar Viktor Vekselberg, die zo'n negen eieren heeft en wordt tentoongesteld in het Fabergé-museum in Sint-Petersburg.

De surprise
De surprise van dit ei is vermist, maar het was een gouden kroon met diamanten en robijnen en een cabochon hanger met robijnen. De kroon was een verwijzing naar Alexandra's nieuwe rol als keizerin.

Externe link
 Meer informatie over Fabergé-eieren

Fabergé-ei

redpajama_set_name: RedPajamaWikipedia


The Centers for Medicare & Medicaid Services (CMS) has updated the Medicare claims processing manual to include guidance for using the Medicare Outpatient Observation Notice (MOON) form.
The form was developed to inform all Medicare beneficiaries when they are an outpatient receiving observation services, and are not an inpatient of the hospital. In December 2016, CMS posted the final MOON form and accompanying form instructions, which hospitals must provide to Medicare beneficiaries who receive outpatient observation services for longer than 24 hours. All hospitals and critical access hospitals will be required to provide the MOON to applicable patients beginning March 8.
how the notices intersect with state laws.


We hope you will continue to enjoy the holidays at the Midwest's Finest Membership Ski Club.
Call 262-246-3090 for up-to-the-minute information.
FOR YOUR SAFETY PLEASE READ AND FOLLOW ALL POSTED SIGNS.
Tuesday | 5:00 – 9:00 PM | Open skiing and race practice.
Wednesday | 6:30 – 11:00 PM | Adults Night (18 and older only).
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Saturday | 10:00 AM – 4:00 PM | Open skiing.
Saturday | 10:00 AM – 11:00 PM | Continuous Skiing (alternating weekends, December 27th. – February 28th).


text:
Showing results by narrator "Michael Chamberlain"
Auggie & Me
Three Wonder Stories
Written by: R. J. Palacio
Narrated by: Michael Chamberlain, Scott Merriman, Taylor Ann Krahn, and others
Length: 8 hrs and 1 min
These stories are an extra peek at Auggie before he started at Beecher Prep and during his first year there. Listeners get to see him through the eyes of Julian, the bully; Christopher, Auggie's oldest friend; and Charlotte, Auggie's new friend at school. Together, these three stories are a treasure for listeners who don't want to leave Auggie behind when they finish Wonder.
By Katja on 2019-04-27
Narrated by: Michael Chamberlain, Scott Merriman, Taylor Ann Krahn, R. J. Palacio
Series: Wonder, Book 1.5-1.7
5 out of 5 stars 23 ratings
The Julian Chapter
A Wonder Story
Written by: R.J. Palacio
Narrated by: Michael Chamberlain
Over one million people have read or listened to and loved Wonder. Now listeners will have a chance to hear from the one of the book's most controversial characters - Julian. From the very first day Auggie and Julian met in Wonder, it was clear they were never going to be friends, with Julian treating Auggie like he had the plague. And while Wonder told Auggie's story through six different viewpoints, Julian's perspective was never shared. Fans could only guess what he was thinking. Until now.
Series: Wonder, Book 1.5
A Lite Too Bright
Written by: Samuel Miller
Arthur Louis Pullman III is on the verge of a breakdown. He's been stripped of his college scholarship, is losing his grip on reality, and has been sent away to live with his aunt and uncle. It's there that Arthur discovers a journal written by his grandfather, the first Arthur Louis Pullman, an iconic Salinger-esque author who went missing the last week of his life and died hundreds of miles away from their family home. Arthur embarks on a cross-country train ride to re-live his grandfather's last week, guided only by the clues left behind in the dementia-fueled journal.
4 out of 5 stars 1 rating
Red State Uprising
How to Take Back America
Written by: Erick Erickson, Lewis K. Uhler
Red State Uprising is not about anarchy or a revolution—it's about reshaping government to maximize economic growth, individual liberty, and private property rights. Barack Obama has shown his determination to move the country towards a socialist "nanny" state, culminating in the government takeover of health care. The vast majority of Americans reject this vision and Red State Uprising calls upon this majority to stand up and take action.


ToothMasters is the superior choice for quality dentures or partial dentures in Alexander City and the surrounding area. If you are looking for a qualified dentist with expertise and experience fitting Alexander City dentures, trust the skilled hands of Dr. Joni Price. Dr. Price has been specializing in denture care since she began practicing in 1995. Prosthetic dentistry is a passion of Dr. Price. Dr. Price will help you decide on the dentures or partials that are best suited for your individual needs and overall oral health.
At ToothMasters, your individual needs will be met with the best options of dentures available in the marketplace. Whether you require customized dentures, immediate dentures or partial dentures, we can help. For reasonably priced Dadeville partial dentures, trust Dr. Price and the team at ToothMasters. Dentures are a cost effective option to traditional crowns or bridges for smile restoration. ToothMasters uses an in-house lab to create your customized dentures and partial dentures. We have a full time, experienced denture lab technician working on our staff to tend to all of your denture adjustments and needs.
If you are looking to be fitted for dentures in LaFayette, Sylacauga or Tallassee, AL, come to ToothMasters in Alexander City. You can rely on the expertise of Dr. Joni Price for quality dentures and partial dentures. We are proud to offer our patients the most advanced denture solutions in all of Alabama. At ToothMasters, our patients come first. We will work hard to enhance your overall oral health and provide you with cost effective dental solutions. Trust the team at ToothMasters for dentures in La Fayette AL. Contact our Alexander City Dentures Experts today.


text:
Pojske is a village in the City of Zenica, Bosnia and Herzegovina.

Demographics
According to the 2013 census, its population was 1,842.

References

Populated places in Zenica


Are you planning a kitchen remodel? Read on and discover some important information that will help you to choose between installing a glass splashback or a granite one.
A glass splashback can make your kitchen look sleek and streamlined. This is because large panels can be used to avoid seams. Tempered glass is the best since it is very hard. The options for finishing the glass are so many that everyone can find something that will meet their needs. For instance, you can opt to have a personalised digital image or a painted image on the backsplash.
Glass splashbacks offer several benefits. First, they are very durable and strong. It is also very easy to clean them, especially if the splashback is seamless. Installation is also easier than for many other materials.
However, you should ensure that the edges of the glass are polished so that the nearby furniture isn't scratched during the installation process. It is also hard and costly to change the colour of the glass splashback once it has been installed. This makes glass a difficult material for homeowners who like to adjust the appearance of their kitchens on a regular basis.
Granite is a material that is suitable for any style of kitchen, such as contemporary or traditional kitchens. Homeowners can choose between a polished and a honed look for the granite. The polished finish is better suited for traditional settings, while the honed look is ideal for those who wish for a contemporary look in their kitchens.
Granite is also very easy to clean. It is extremely durable, and one can find it in a variety of colours. The stones are so unique that is hard to find any two installation sites that look identical.
However, granite is a very costly material. It may therefore be out of reach for the homeowner with a tight budget. Some granite splashbacks are so porous that wet marks will remain visible for a long time. One may have to incur the cost of sealing the stone on a regular basis in order to keep stains from this porous material.
As you can see from the discussion above, each of these materials has its own strong and weak points. However, glass splashbacks seem to be easier to maintain when compared to the different challenges that result from the porosity of granite. Talk to an expert and get technical guidance so that you can learn how to deal with the daily requirements of the option that you select.


text:
// Copyright 2018 The Chromium Authors. All rights reserved.
// Use of this source code is governed by a BSD-style license that can be
// found in the LICENSE file.

#include "content/browser/devtools/devtools_renderer_channel.h"

#include "base/bind.h"
#include "base/bind_helpers.h"
#include "content/browser/devtools/devtools_agent_host_impl.h"
#include "content/browser/devtools/devtools_session.h"
#include "content/browser/devtools/protocol/devtools_domain_handler.h"
#include "content/browser/devtools/protocol/target_auto_attacher.h"
#include "content/browser/devtools/worker_devtools_agent_host.h"
#include "content/public/browser/render_process_host.h"
#include "content/public/common/child_process_host.h"
#include "ui/gfx/geometry/point.h"

namespace content {

DevToolsRendererChannel::DevToolsRendererChannel(DevToolsAgentHostImpl* owner)
    : owner_(owner),
      process_id_(ChildProcessHost::kInvalidUniqueID) {}

DevToolsRendererChannel::~DevToolsRendererChannel() = default;

void DevToolsRendererChannel::SetRenderer(
    mojo::PendingRemote<blink::mojom::DevToolsAgent> agent_remote,
    mojo::PendingReceiver<blink::mojom::DevToolsAgentHost> host_receiver,
    int process_id,
    base::OnceClosure connection_error) {
  CleanupConnection();
  blink::mojom::DevToolsAgent* agent = nullptr;
  if (agent_remote.is_valid()) {
    agent_remote_.Bind(std::move(agent_remote));
    agent = agent_remote_.get();
  }
  if (connection_error)
    agent_remote_.set_disconnect_handler(std::move(connection_error));
  if (host_receiver)
    receiver_.Bind(std::move(host_receiver));
  const bool force_using_io = true;
  SetRendererInternal(agent, process_id, nullptr, force_using_io);
}

void DevToolsRendererChannel::SetRendererAssociated(
    mojo::PendingAssociatedRemote<blink::mojom::DevToolsAgent> agent_remote,
    mojo::PendingAssociatedReceiver<blink::mojom::DevToolsAgentHost>
        host_receiver,
    int process_id,
    RenderFrameHostImpl* frame_host) {
  CleanupConnection();
  blink::mojom::DevToolsAgent* agent = nullptr;
  if (agent_remote.is_valid()) {
    associated_agent_remote_.Bind(std::move(agent_remote));
    agent = associated_agent_remote_.get();
  }
  if (host_receiver)
    associated_receiver_.Bind(std::move(host_receiver));
  const bool force_using_io = false;
  SetRendererInternal(agent, process_id, frame_host, force_using_io);
}

void DevToolsRendererChannel::CleanupConnection() {
  receiver_.reset();
  associated_receiver_.reset();
  associated_agent_remote_.reset();
  agent_remote_.reset();
}

void DevToolsRendererChannel::ForceDetachWorkerSessions() {
  for (WorkerDevToolsAgentHost* host : child_workers_)
    host->ForceDetachAllSessions();
}

void DevToolsRendererChannel::SetRendererInternal(
    blink::mojom::DevToolsAgent* agent,
    int process_id,
    RenderFrameHostImpl* frame_host,
    bool force_using_io) {
  ReportChildWorkersCallback();
  process_id_ = process_id;
  frame_host_ = frame_host;
  if (agent && !report_attachers_.empty()) {
    agent->ReportChildWorkers(true /* report */,
                              !wait_for_debugger_attachers_.empty(),
                              base::DoNothing());
  }
  for (DevToolsSession* session : owner_->sessions()) {
    for (auto& pair : session->handlers())
      pair.second->SetRenderer(process_id_, frame_host_);
    session->AttachToAgent(agent, force_using_io);
  }
}

void DevToolsRendererChannel::AttachSession(DevToolsSession* session) {
  if (!agent_remote_ && !associated_agent_remote_)
    owner_->UpdateRendererChannel(true /* force */);
  for (auto& pair : session->handlers())
    pair.second->SetRenderer(process_id_, frame_host_);
  if (agent_remote_)
    session->AttachToAgent(agent_remote_.get(), true);
  else if (associated_agent_remote_)
    session->AttachToAgent(associated_agent_remote_.get(), false);
}

void DevToolsRendererChannel::InspectElement(const gfx::Point& point) {
  if (!agent_remote_ && !associated_agent_remote_)
    owner_->UpdateRendererChannel(true /* force */);
  // Previous call might update |agent_remote_| or |associated_agent_remote_|
  // via SetRenderer(), so we should check them again.
  if (agent_remote_)
    agent_remote_->InspectElement(point);
  else if (associated_agent_remote_)
    associated_agent_remote_->InspectElement(point);
}

void DevToolsRendererChannel::SetReportChildWorkers(
    protocol::TargetAutoAttacher* attacher,
    bool report,
    bool wait_for_debugger,
    base::OnceClosure callback) {
  ReportChildWorkersCallback();
  set_report_callback_ = std::move(callback);
  if (report) {
    if (report_attachers_.find(attacher) == report_attachers_.end()) {
      report_attachers_.insert(attacher);
      for (DevToolsAgentHostImpl* host : child_workers_)
        attacher->ChildWorkerCreated(host, false /* waiting_for_debugger */);
    }
  } else {
    report_attachers_.erase(attacher);
  }
  if (wait_for_debugger)
    wait_for_debugger_attachers_.insert(attacher);
  else
    wait_for_debugger_attachers_.erase(attacher);
  if (agent_remote_) {
    agent_remote_->ReportChildWorkers(
        !report_attachers_.empty(), !wait_for_debugger_attachers_.empty(),
        base::BindOnce(&DevToolsRendererChannel::ReportChildWorkersCallback,
                       base::Unretained(this)));
  } else if (associated_agent_remote_) {
    associated_agent_remote_->ReportChildWorkers(
        !report_attachers_.empty(), !wait_for_debugger_attachers_.empty(),
        base::BindOnce(&DevToolsRendererChannel::ReportChildWorkersCallback,
                       base::Unretained(this)));
  } else {
    ReportChildWorkersCallback();
  }
}

void DevToolsRendererChannel::ReportChildWorkersCallback() {
  if (set_report_callback_)
    std::move(set_report_callback_).Run();
}

void DevToolsRendererChannel::ChildWorkerCreated(
    mojo::PendingRemote<blink::mojom::DevToolsAgent> worker_devtools_agent,
    mojo::PendingReceiver<blink::mojom::DevToolsAgentHost> host_receiver,
    const GURL& url,
    const std::string& name,
    const base::UnguessableToken& devtools_worker_token,
    bool waiting_for_debugger) {
  if (content::DevToolsAgentHost::GetForId(devtools_worker_token.ToString())) {
    mojo::ReportBadMessage("Workers should have unique tokens.");
    return;
  }
  RenderProcessHost* process = RenderProcessHost::FromID(process_id_);
  if (!process)
    return;
  GURL filtered_url = url;
  process->FilterURL(true /* empty_allowed */, &filtered_url);
  auto agent_host = base::MakeRefCounted<WorkerDevToolsAgentHost>(
      process_id_, std::move(worker_devtools_agent), std::move(host_receiver),
      filtered_url, std::move(name), devtools_worker_token, owner_->GetId(),
      base::BindOnce(&DevToolsRendererChannel::ChildWorkerDestroyed,
                     weak_factory_.GetWeakPtr()));
  child_workers_.insert(agent_host.get());
  for (protocol::TargetAutoAttacher* attacher : report_attachers_)
    attacher->ChildWorkerCreated(agent_host.get(), waiting_for_debugger);
}

void DevToolsRendererChannel::ChildWorkerDestroyed(
    DevToolsAgentHostImpl* host) {
  child_workers_.erase(host);
}

}  // namespace content

redpajama_set_name: RedPajamaGithub


We perform on the shoulders of giants, past and present. You can size up those giants in biographies of their lives and times. Perfecting a magic trick is rewarding, but learning about the creator behind it is a sure way to enjoy it even more.
Doubleday 1966, hard cover, 221 p.
Jeff Busby, 2nd printing 1991, soft cover, comb bound, 463+vi p.
Samuel & Lee Smith, 1st ed. 1977, soft cover, 112 p.
Supreme 1982, hard cover, damaged dust jacket, 232 p.
L&L 2000, hard cover, dust jacket, 207 p.
Ann Eliza Heathman was born in 1849. Her ability to make people believe she could summon the shades of the departed brought her to the attention of H. Melville Fay, an unscrupulous fraudulent medium. Under his guidance, Annie conquered America and then Europe, becoming Anna Eva Fay, the girl who baffled William Crookes, one of the most respected scientists of the age.
Hermetic Press 2005, hard cover, dust jacket, 454 p.


text:
Home About Us Shows Auditions Contact
Coming Auditions:
Unnecessary Farce
by Paul Slade Smith
Directed by Paul McKenzie
Auditions:
Saturday, April 21 from 11:00 am to 2:00 pm
Sunday, April 22 from 11:00 am to 2:00 pm
Audition appointments are strongly recommended. To request an appointment, please send an email to notrightproductions@gmail.com
Auditions will be held at Rover Dramawerks
221 W. Parker Road, Suite 580 in Plano, at the northwest corner of 75 and Parker Rd., in the Ruisseau Village Shopping Center.
Brief Synopsis:
Two cops. Three crooks. Eight doors. Go. In a cheap motel room, an embezzling mayor is supposed to meet with his female accountant, while in the room next-door, two undercover cops wait to catch the meeting on videotape. But there's some confusion as to who's in which room, who's being videotaped, who's taken the money, who's hired a hit man, and why the accountant keeps taking off her clothes.cops. Three crooks. Eight doors. Go. In a cheap motel room, an embezzling mayor is supposed to meet with his female accountant, while in the room next-door, two undps
Roles: Seeking a talented and diverse cast to play roles from 20 to 70. Descriptions are from the script. Ages listed below are representative and should not deter you from auditioning for the show if you think you can play the part. All roles are available.
ERIC SHERIDAN (Male, 30s) - a police officer. Bookish, even-keeled guy who finds himself completely out of his element when called upon to express his feelings for a woman, lie to his boss, disguise himself as someone else, and stand up to an armed mobster - while not wearing any pants.
BILLIE DWYER (Female, 20s/30s) - a police officer, Eric's partner. Excitable and entirely un-threatening, she seemingly lacks every skill necessary for police work, but is as eager to succeed as she seems destined to fail.
KAREN BROWN (Female, 30s) - an accountant, who has always taken pride in her accountant-like, professional demeanor - until this morning, when she finds herself filled with a sexual hunger, and unable to keep things in control.
MAYOR MEEKLY (Male, 40s-70s) - an Innocent, with a capital I. An affable, gentle fellow. Not too quick on the pick-up, but a sweet, sweet soul.
AGENT FRANK (Male, 20s - 50s) - the head of Security at Town Hall, and frankly, the wrong man for the job. Though he presents the confident, gruff exterior of a secret service agent (or film noir detective, even), he is frequently (and, at moments of crisis, invariably) a man frightened by his own shadow.
TODD (Male, 20s-50s) - speaks with a pronounced Scottish accent. A professional hitman. Cool, quiet, and perceptive when at his best, but more frequently an angry Scotsman - and the angrier he becomes, the thicker his accent gets, until he is entirely indecipherable.
MARY MEEKLY (Female, 40s-70s) - the Mayor's wife. Small in stature and unfailingly sweet, she seems, in every way, the perfect match for her husband.
· Auditions will consist of cold reading from the script.
· Please bring a resume and head shot.
· There are no stipends available for the show.
· Rehearsals will be in Plano and Richardson will begin around the week of April 29. Exact rehearsal schedule TBA but all conflicts must be noted at time of audition. Rehearsals are typically Sunday - Wednesday, but may include some Thursday, Friday or Saturdays.
Unnecessary Farce runs June 7 to 16
Thursday June 7 (Preview) and Thursday, June 14 at 8:00 PM
Friday, June 8 and Friday, June 15 at 8:00 PM
Saturday, June 9 and Saturday, June 16 at 3:00 and 8:00 PM
All performances will take place at Rover Dramawerks, 221 W. Parker Rd., Suite 580, Plano 75023.


text:
Quiet, musically talented,
people pleaser, best friend.
"I really miss our talks," said Matt's mother Denise. "He was so wise, always giving logical, well thought-out answers."
Matt grew up with his parents, Denise and Tim Williams, in a loving household, along with his twin brother Ryan and their younger sister Katie in Pasadena, Maryland.
As a middle-school student Matt began experiencing some anxiety and depression. He didn't share it with his family at first.
Meanwhile, Matt excelled in music in school. He played the violin, clarinet, piano and guitar. He was in the school marching band, but his real love was his "garage band," that he enjoyed with some school buddies.
He had lots of friends in school and shared his love of extreme sports with his twin brother, Ryan. He never made enemies, only friends.
After graduating high school in 2003, Matt went to work in his father's shop as a welder and a machinist, but he also attended classes part-time at Anne Arundel Community College for about two years. He dreamed of becoming an architect.
Matt was very smart and an expert at answering trivia questions; often surprising his family and friends with his knowledge.
Matt's life took a tragic turn after he was involved in a horrific car accident in 2007 when he was 22 years old. Matt endured seven surgeries following the accident and was introduced to opioids for the first time during that ordeal. He soon became addicted to opioids and attended the first of several 30-day rehab programs over the next eight years.
He managed to gain two years of sobriety during his years of addiction, but his twin brother's death from a drug overdose in 2015 eventually took a toll on him. "He agonized over it," Denise said.
Matt died three years and 20 days after his twin brother, Ryan.
Their mother, Denise, continues to operate her non-profit and donates time and money to help others fighting drug addiction. Funds also go toward purchasing and packaging personal care bags for Anne Arundel County Crisis Response Team.
She finds comfort in helping others.
Information for this profile was provided by Matt's mother, Denise Williams.
APRIL 28, 1985 – FEB. 18, 2018
He lived with addiction 11 years
← Ryan Williams
James "Dillon" Venable →


© 2010 Qihui Zhang. All rights reserved. No part of this publication may be reproduced without the written permission of the copyright holder.
This study investigates visibility in a smoke laden environment. For many years, researchers and engineers in fire safety have criticized the inadequacy of existing theory in describing the effects such as colour, viewing angle, environmental lighting etc. on the visibility of an emergency sign. In the current study, the author has raised the fundamental question on the concept of visibility and how it should be measured in fire safety engineering and tried to address the problem by redefining visibility based on the perceived image of a target sign. New algorithms have been created during this study to utilise modern hardware and software technology in the simulation of human perceived image of object in both experiment and computer modelling. Unlike the traditional threshold of visual distance, visibility in the current study has been defined as a continuous function changing from clearly discemable to completely invisible. It allows the comparison of visibility under various conditions, not just limited to the threshold. Current experiment has revealed that different conditions may results in the same visual threshold but follow very different path on the way leading to the threshold. The new definition of visibility has made the quantification of visibility in the pre-threshold conditions possible. Such quantification can help to improve the performance of fire evacuation since most evacuees will experience the pre-threshold condition. With current measurement of visibility, all the influential factors such as colour, viewing angle etc. can be tested in experiment and simulated in numerical model.
Based on the newly introduced definition of visibility, a set of experiments have been carried output in a purposed built smoke tunnel. Digital camera images of various illuminated signs were taken under different illumination, colour and smoke conditions. Using an algorithm developed by the author in this study, the digital camera images were converted into simulated human perceived images. The visibility of a target sign is measured against the quality of its image acquired. Conclusions have been drawn by comparing visibility under different conditions. One of them is that signs illuminated with red and green lights have the similar visibility that is far better than that with blue light. It is the first time this seemingly obvious conclusion has been quantified.
In the simulation of visibility in participating media, the author has introduced an algorithm that combines irradiance catching in 3D space with Monte Carlo ray tracing. It can calculate the distribution of scattered radiation with good accuracy without the high cost typically related to zonal method and the limitations in discrete ordinate method. The algorithm has been combined with a two pass solution method to produce high resolution images without introducing excessive number of rays from the light source. The convergence of the iterative solution procedure implemented has been theoretically proven. The accuracy of the model is demonstrated by comparing with the analytical solution of a point radiant source in 3D space. Further validation of the simulation model has been carried out by comparing the model prediction with the data from the smoke tunnel experiments.
The output of the simulation model has been presented in the form of an innovative floor map of visibility (FMV). It helps the fire safety designer to identify regions of poor visibility in a glance and will prove to be a very useful tool in performance based fire safety design.


Smart-looking mid-sized crossover, Q5 mixes space with fine driving dynamics. It's difficult to stress enough how much better designed and resolved this car is. Drives and feels like a luxury sedan. Great car to have .


I don't think there is any doubt in mind about the energy of papaya. That is why, in this article I'll not discuss about this fruit today, rather i'll discuss about one intimate companion of papaya , that is also behind the eye sight and whose name is not respected. Even So, it is fighting against thousands of diseases for thousand years. Multiple studies have shown that not only to kill the dengue virus but also there is no substitute of papaya leaves to keep multiple diseases away. But surprisingly many people still now don't look for the quality of this natural element. So, I've decided to write this article.
In many studies, it has been proved that the risk of decreasing platelet count decreases in the body due to regular drinking of papaya leaf juice. Along with that, the immune system also became very strong. Once the urine system becomes stronger, the danger of being infected with the dengue virus is not enough. In fact, in the last few months, with the increase in the incidence of Dengue and Chikungunya in the world, there is no doubt that the need to utilize this element has increased.
The papaya contains Acetogenin; anti-malarial properties, in the inside of the leaf. After entering it into the body makes so strong that it can not even affect to the diseases like malaria. Therefore, we should not avoid the company of the papaya leaves to save us from the mosquito's torture!
Several case studies have proved that many useful substances present on the papaya leaf brings out the toxic elements from the liver. At the same time, the liver's performance increases so much that the fear of getting infected with various diseases decreases. In fact, this genuine element plays a special role to keep jaundice disease away.
After entering the two components called protease and amylase in the papaya leaf, digestive detergent in digestion increases so much that the digestive system begins to increase. Along with the reduction of stomach and colon inflammation, it also plays a special role in the development of the Bowell Movement. In fact, more than one study found that regular papaya leaf juice was consumed by the death of H-pylori bacteria. As a result, the tendency of naturally occurring pathogenic ulcer is decreased.
Are you worry for the growing sugar in blood? So start drinking regular papaya leaves juice from today. See if the benefits are met. Because some of the useful ingredients in it increase insulin performance. As a result, there is no danger of increasing the level of sugar in the body.
From now on this special days of the month start eating papaya leaf juice. See, both cramps and pain will reduce. Actually, anti-inflammatory progeny in the papaya leaf, on the one hand, reduces the incidence of reducing inflammation in the body, while on the other hand, eliminating hormonal imbalance plays a special role in reducing various other problems.
Antioxidant is an element that reduces the risk of getting cancer cells out of the toxic material from the body. And this ingredient contains abundant storage of papaya leaves inside the interior. So if you can drink papaya leaf juice regularly, then there is no worry for cancer. In fact, several studies have found that many enzymes present in the papaya leaf play a special role in preventing liver, long, pancreatic and breast cancer.
Get fresh healthy mature papaya leaves from a fruit-bearing tree.
Wash the leaves thoroughly with running tap water and chop the leaves in to small pieces excluding the main stem (not necessary to remove the small stems in the leaves).
Weigh 50g of papaya leaves and put it into a mortar and pestle.
Add 50ml of boiled cool water and 25g of sugar.
Pound the above mixture well for 15 minutes till a uniform pulp is made.
Mix this pulp well and keep for about 30 minutes.
Squeeze this pulp by hand and get the papaya leaf extract (don't use a cotton sieve to extract the juice).
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text:
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