Tomorrow is November 11th. The Eleventh Day, of the Eleventh Month. This time, it's also the Eleventh Year. It only happens once per year that the day, month and year are the same TWO numbers. Next year, it'll match on December 12th – 12/12/12. Even so, the next time we see a row with the same number in every slot, it'll be what year? I'm taking into account the fact that usually we write "03/23/09", or something like that. Therefore, even 12/12/12 doesn't count here. No, indeed, it does not at all. Nor did 10/10/10. Yes, tomorrow is a red letter day. I'd advise making the most of it.
For many, it's a day of Remembering. It began with the signing of the Armistice between the warring sides of the Great War, now called WWI since we ended up with another Great War, #2, starting in 1939. That being said, the number of countries involved was massive. Everyone was happy that it came to an end and it seemed good to celebrate. On the 11th day of the 11th month, at the 11th hour, a moment of silence is taken to remember all who have given. In some places it's Veterans Day, in others it's Remembrance Day, and in others yet it's still Armistice Day. In some countries, it's celebrated on the Sunday closest to the 11th. At any rate, it's important.
But, in my perambulations around and about this spinning orb of humanity, I've come across many types of holidays. My point being: we have a right to decide what to celebrate, and when, and how. Whether it's traditions from centuries ago carried over to today, or something we just made up yesterday, we've a right to celebrate it.
Take tomorrow for example. Were you it South Korea, it'd be a grave faux pas should you forget Pepero Day. Well, maybe not that grave. It's a day sort of like Saint Valentine's Day in other places; you give presents of Pepero to the people you like, sort of like our tradition of giving poor quality over priced candy to your Valentine. You see, Pepero is a snack. It's a pretzel stick covered with chocolate, or other flavors. 11/11 is perfect for the holiday because the elevens look like four Peperos lined up. But, tomorrow is really important because it's SIX elevens lined up. Goodness, a millennial event. In Japan they have a similar snack named Pocky, and it's Pocky Day in Japan tomorrow. I think pretzels deserve their own holiday, whether knotted or straight, plain or dipped. Honor thy pretzels!
Another holiday occurs tomorrow very much worth noting, and one which I do plan on celebrating (at least a bit) as well: The King's Birthday in Bhutan. November 11 is the holiday honoring the birthday of the 4th King of Bhutan, . Now, although I am not Bhutanese, nor have I ever actually been there on November 11th, I find it terribly important to honor a leader who decided that Gross National Happiness (GNH) was a much better thing to measure than just Gross National Product (GNP – money, in other words). Jigme Singye Wangchuck, the 4th King of Bhutan, thought that it would be terribly smart to run the country based on ideas of happiness and wellness for his people based on Buddhist principles. Quite sophisticated formulae were devised to, indeed, measure the happiness of the people. That does strike me as wonderfully intelligent!
Therefore, after remembering Remembrance Day, I intend to do something to honor the King of Bhutan's birthday. It's doubtful that it will include Pepero, since I'm not sure where to buy some on short notice.
I must beg forgiveness! I nearly neglected in my writings to mention another Augustus Personage whose day is celebrated upon the 11th of November. That would be the maestro of Eleven, Nigel Tufnel! As a composer, guitarist and touring musician myself, I have always heartily concurred with Mr. Tufnel in his assertion that any electric musical instrument amplifier which ranges up to a maximum volume of "11" is better than one which tops out at a mere "10". Alas, I have as yet not succeeded in finding an example of that rare Equipage, but optimism rules and I am confident that I shall. Hats Off and Eleven Cheers for Mr. Nigel Tufnel and His Day, and all the Spinal Tap gentlemen! Hurrah! Hurrah! Hurrah! Hurrah! Hurrah! Hurrah! Hurrah! Hurrah! Hurrah! Hurrah! Hurrah!
…that was eleven, right? Ah. There's my taxi. I must be off. We'll chat again, very soon.
Two interesting "Dies Propensus" – important days – occur within the next two days. The first is of an historical nature. November 18th is, as those who've Googled anything today will already know, the birthday of Louis-Jacques-Mandé Daguerre, inventor of the Daguerreotype. Daguerrotypes were perhaps the earliest or at least the most brilliant and accurate photographic images. It is an amazing process that Daguerre and several others had been working on. Daguerre himself had wrestled with the question for nearly 20 years. He'd been intrigued with the idea of capturing the images created by the Camera Obscura, a device used by painters and draftsmen for drawing images. This device is itself already a more advanced version of the pinhole camera, a device and principle known as far back as Aristotle in the mid-300s B.C.
Yes, Daguerre was brilliant in creating what amounts to modern photography, but his legacy also involves the invention of the Paris Diorama, in its own way just as interesting. The concept of the Diorama was brilliant: large paintings were made on screens more or less opaque, or with sections more or less so. Using a system of pulleys, mirrors, windows, screens, and a rotating platform upon which sat the audience, the Diorama could, for example, produce the effect of watching the progress of a violent storm. This invention of Daguerre amounted to the first "picture shows"! We know of Daguerre through his invention of early photography, but before that he was a fine artist, a painter in the Romantic style who also understood theatre, scenery, and lighting. Unfortunately, his Diorama burnt to the ground in 1839 with the loss of most of his notes about the Daguerreotype as well an many early photos, and all of the scenes from his building. Ah, well.
The other day upon which I wish to discourse is International Toilet Day. Yes, indeed, the toilet has its own day. Worldwide, no less. Now, while it might seem fun (oh, let's face it, it IS fun) to make jokes about toilets, and upon International Toilet Day, for many it's no laughing matter. Modern sanitary toilets, sewers and water treatment have done much to improve public health. Curiously, mechanisms for using hydraulic movement to wash away waste have been known for nearly 3500 years.
And yet, many around the world have no way to dispose of their waste in such a fashion as to isolate it from water used for other purposes. The result is sickness, and yes, death. Often of very young children. So, International Toilet Day, the 19th of November, is a day upon which to marvel at the conveniences many (I count myself among them) enjoy in the Modern World. We take these for granted, they have made our lives better, and not everyone has the luxury of these luxuries. Think upon that tomorrow, if you will. And, thank Thomas Crapper in England for popularizing the flush toilet. Hats off to Thom. Crapper!


Just a sampling of Caroline's paintings available at Lahaina Galleries "Gift of Art" Holiday Soirée, Saturday, December 8, 2018 4-7PM at Fashion Island in Newport Beach.
These wonderful small and medium sized original oil paintings make great holiday gifts!
Unique, creative and highly personal gifts. Five artists. Exclusive show incentives. Festive gift wrapping.
These original paintings are now available for purchase online, directly from the Virtual Gallery at carolinezimmermann.com.
View all available paintings at Caroline's Virtual Gallery.
*All paintings are custom framed with Italian molding.
"Earth's Natural Wonder and Beauty" featuring Caroline Zimmermann, Lorie Wylie, Steve Matson and Cheryl Kline.
Please join 4 amazing artists for an evening of fine art that celebrates Earth's natural wonder and beauty. View the paintings here.
"Maui Harbor Reflections" 36″ X 49″ Oil on canvas.
I've painted outdoors and I've painted indoors… on location and in studios all over the world. People often ask me: Which do I prefer? Is one more authentic? Is the other easier? Over the years I'm thinking it is all up to the individual, what gets you stoked as a painter, what inspires your process.
I suppose that when it comes to art studios, I've been fortunate enough to have worked in some amazing spaces in the world. Some were corners in a room, others covered patios, basements, cantinas, spare rooms, garages and shared spaces with other artists. Some spaces I have lived and slept in, some had great surf and snowboarding right outside the door. Some studios have been the backdrop for tea parties, holiday parties, and art shows…others transformed into movie sets for numerous film projects. From the ancient olive mill in Tuscany to the the old Del Monte Cannery in San Francisco, all these spaces impart their energy into my work and inspire in their own unique ways.
In this, my 30th year as a professional artist, I'm looking back at those places with many fond recollections. The hundreds if not thousands (!) of paintings I have created over those years!
Since the era of the Medici and the Renaissance, Florence has been famous for its artisans, artists and crafts people who have created many of art history's finest treasures. My numerous visits to the museums of Florence have inspired me over the years as I view the countless masterpieces of Renaissance art, and noting with little exception, the magnificence of their frames.
This last weekend I had the honour of exhibiting my work at Lahaina's 39th Anniversary Show. Along with seven other master artists, we celebrated with some of Lahaina Galleries' patrons and collectors at a private unveiling the evening before.
Over 20 years ago, during my first visit to the Musee d'Orsay in Paris, I saw a painting that has inspired me ever since.
The End of Summer 2013's most welcome news is my being taken on by Lahaina Galleries for representation.
Callie Wray and her fantastic team at their Fashion Island gallery have made me feel most welcome.
Sunflowers speak to me of happy and content memories in my family's garden in Anaheim.


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Categories National
Who is Arpita Mukherjee? Why is she called Cash Queen?
by Editor August 2, 2022 August 2, 2022 Leave a Comment on Who is Arpita Mukherjee? Why is she called Cash Queen?
Model Arpita Mukherjee is from a middle-class Belghoria family in Kolkata. Arpita frequently appears in Naktala Udayan Sangha's advertising and is one of the group's promotional spokespersons.
Arpita describes herself as a model and actress in 2004. She began her career as a model and nail technician before breaking into Bengali cinema. After a few years of effort, Arpita Mukherjee was cast in a brief cameo in the Bengali movie "Mama Bhagne" (2010), "Bangla Banchao and "The Bhoot of Roseville". She later went on to perform in Tamil and Odia movies. Arpita Mukherjee, according to her mother, also operates a production company.
In only a few days, Arpita Mukherjee went from being hardly recognized outside of the film industry to being a household name. She gained notoriety and is infamously known as the cash Queen after it came to light that she is a close aide of Senior Trinamool Congress (TMC) leader and West Bengal minister Partha Chatterjee, who is currently being detained by the Enforcement Directorate (ED) over allegations of involvement in the state's school recruitment scam. Arpita Mukherjee gained infamy after the Enforcement Directorate searched one of her residences and reportedly found wads of cash there totaling more than Rs. 21 crores.
Arpita Mukherjee Association with Partha Chatterjee
Arpita Mukherjee has been seen frequently travelling with Partha Chatterjee to a variety of public and social events, such as the Durga Puja. In 2021, she was even included on the record cover of the puja's music and participated in Partha Chatterjee's campaign during the Bengal assembly elections in 2021.
Bengal Teacher SSC Recruitment Scam
The West Bengal School Service Commission (SSC) announced in 2014 that teachers will be hired at state-run schools in West Bengal through the State Level Selection Test (SLST) or WBSSC exam, which is when the alleged fraud first surfaced. The Bengal SSC Scam took place when Partha Chatterjee was the Minister-in-Charge of the West Bengal Department of Higher Education and School Education in 2016.
Many test takers who received lower scores, according to the petitioners in the WBSSC exam, were listed highly on the merit list. Several claims also surfaced about the receipt of appointment letters in the Teacher Recruitment Scam by certain applicants who weren't even on the merit list. Nevertheless, a number of complaints were submitted to the Calcutta High Court citing irregularities in the hiring procedure in the West Bengal Scam.
West Bengal SSC Exam Scam
The alleged swindle apparently occurred between 2014-21 while Partha Chatterjee served as education minister. Chatterjee is claimed to be involved in the scam that involves occurrence of unlawful hiring practices, candidates with lower test scores placed highly on the merit list, and accepted payment in exchange for placing candidates in employment.
Partha Chatterjee and his close aide Arpita Mukherjee were arrested on Saturday, July 23, 2022, in connection with the West Bengal School Service Commission (WBSCC exam) and West Bengal Primary Education Board recruitment fraud. Enforcement Directorate organized a raid on Chatterjee, Paresh Adhikari, and many other people's home. Arpita Mukherjee's ED raid at her property led to a discovery of a large amount of cash, estimated to be worth Rs 21 Crore.
The aforementioned sum was thought to be the revenues from the Bengal SSC Scam. For this purpose, a total of more than 20 mobile phones that were found inside Arpita Mukherjee's ED raid at home, according to the investigation agency.
Along with cash, several additional condemning documents, records, information about shady businesses, technological gadgets, foreign money, and gold have also been found at the different locations where the scammers were staying. According to sources, the investigating agency also uncovered several WBSSC exam papers and student admission cards in Mukherjee's flat and Partha Chatterjee's home during the raids, as well as other property-related paperwork in Chatterjee's home.
In compliance with the Calcultta High Court's orders, Arpita Mukherjee and Partha Chatterjee were taken to the hospital on Friday for a medical checkup. They both made a theatrical spectacle while refusing to get out of the automobile. The authorities compelled them to travel to the hospital for their medical examination. This incident also led to a war of words between BJP and TMC.
After a large amount of cash was found at her home, Arpita is recognized as the "Cash Queen." The investigators are currently looking for Cash Queen's high-end vehicles as they tighten the noose around the former minister's aide. According to rumours, her four expensive vehicles—an Audi A4, a Honda City, a Honda CRV, and a Mercedes Benz—have vanished. A substantial cash haul of around Rs 50 crore as well as gold bars worth more than Rs 5 crore have already been recovered by the ED.
Keep following WBDSTBT for latest news on Arpita Mukherjee.
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From Irv's Luggage facebook contest. We just chose the winner for our North Face backpack contest, and you are it! Congrats!
Thanks so much for entering. We're so excited to send out your borealis backpack in black.


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Tim Heidecker on The Comedy
by Jane Schoenbrun
in Actors, Interviews
Eric Wareheim, Kate Lyn Sheil, Rick Alverson, The Comedy, Tim and Eric Awesome Show Great Job, Tim Heidecker, Tribeca Film Festival, Will Oldham
It's unlikely that anyone had a more schizophrenic Sundance this past January than Tim Heidecker. The 36-year old actor and filmmaker attended the festival with two projects – Tim and Eric's Billion Dollar Movie, the feature-length culmination of his and longtime collaborator Eric Wareheim's cult absurdist comedy TV series Tim and Eric Awesome Show, Great Job!, and the ironically named The Comedy, a dark drama from filmmaker Rick Alverson (New Jerusalem). And as both films have rolled out over the past year, Heidecker has had to juggle dueling personae – zany comedic curmudgeon and dramatic leading man.
In The Comedy, Heidecker plays Swanson, a depressed, affluent, and serially-detached Williamsburg hipster. Throughout the film, Swanson engages in a series of provocations with the outside world, testing the limits and boundaries of those around him, while arguably spiraling towards some kind of mental break. It's a dark, pitiless performance — an unmistakable departure from Heidecker's past work that still manages to comment on everything he's done previously.
Filmmaker: Was indie film something you've always been interested in pursuing?
Heidecker: I went to film school, and I did a lot of theater in high school. Honestly, back then, comedy never seemed like a thing that was possible. When Eric and I met in film school, we really thought that we were going to make movies. That's what we went there for. I'm a huge fan of all kinds of weird independent cinema. But comedy was something that was always fun, and it just began to become the way that we expressed ourselves.
When this came around, Eric and I had just finished Awesome Show. And after we saw Rick Alverson's first film, we felt that this guy had a really great eye, and great control. It seemed like it would be a really interesting direction to go in – an interesting thing to try to do – to connect back to that love of film we had.
Filmmaker: How did Rick get on your radar?
Heidecker: I got a text from Will Oldham – also known as "Bonnie Prince Billy" – who was in Rick's previous movie, New Jerusalem. Will sent me a text that said, "Do you have any interest in acting in a movie?" And I said, "Sure, why not?"
Filmmaker: What about this character drew you in?
Heidecker: I had lived in Williamsburg for years before moving to Los Angeles, and I knew a lot of people like Swanson. Part of me is like Swanson. The first conversations with Rick were about how we wanted to find actors or people that could talk to each other in a sort of casually offensive, cruel language, where it's not really about what's being said, where none of that stuff is meaningful. Instead it's just all about the language, and the aspiration to make your friends laugh as opposed to hurting their feelings. We talked about how we haven't really seen a lot of good movies where you capture that really naturalistic way that guys talk to each other. And then we talked about the arrested development of these guys, guys who go to art school or play in a band who never really settle into a career or a family. And they end up looking around, and they're like 36, and they're in Brooklyn, and they're still living with roommates, and they still have rock posters on the wall.
We talked about there being different modes that this character would be in. He'd be in a social mode, or he'd be in a shut-down mode, or in an "I'm out of my element and I'm pushing the boundaries" mode. We talked about Swanson as being on the verge of some kind of nervous breakdown or something. It really isn't specific in the film – and it shouldn't be – but he's in the midst of some kind of life moment. So the preparation was really about understanding this guy's sense of humor, and understanding some very simple things about him. And then it was just, "Let's relax, try to make something, and not try to overanalyze too much."
Filmmaker: How much did you develop the character's backstory? The film hints at a dysfunctional past, but how much of this was concrete to you on set?
Heidecker: There was not a lot of method acting homework being done. I think Rick and I both don't believe that's necessary. I don't, at least.
I understood the basic facts of the character – that he had wealth, and a father that he had issues with. But beyond that, I just don't find backstory helpful. It just becomes a mess for me. Maybe it would work in other situations, but with this I tried to be as naturalistic as possible, and as understated as possible. I think if I had cluttered that up with all sorts of backstory to remember it probably would have made my life more stressful.
Tim Heidecker in The Comedy
Filmmaker: You said that you share traits in common with Swanson. How are you two similar?
Heidecker: I didn't try to create an alternate sense of humor or delivery style. We share a style. We can both be sarcastic and goofy. That's how I try to communicate.
But aside from that, all the content of what Swanson says and does – I would never put anybody in any of those positions. It's like you might be sitting around a bar drinking beer, and you get into a routine with your close friends that's like, "I'm going to rape you with my own shit filled piss." But that's not about the reality of it; it's about the absurdity of it. And that's where I think my character and I separate: – he brings those kinds of conversations into the real world, and to people who aren't on the same page.
Filmmaker: It seems like he's using that sense of irony to mask something else, some kind of deep-seated anger or loneliness.
Heidecker: I think it's recreational. Rick used the world "recreational" a lot in describing this movie. We both saw it as a time-passer, this way that Swanson amuses himself in a depraved sort of way. The movie should make you think about the leisure class, and the fact that there are a lot of people out there who don't have a lot to do. And I'm guilty of this too. There's so much you can accomplish now in such a short period of time. And there are so many things that are done for you, especially with a character like Swanson, who probably doesn't have to worry about working. You end up having a lot of time to fill in your life. And if you don't have a family, and if you don't have a religion, and you don't participate in the government, you're left with this idle hands sort of phenomenon.
Filmmaker: Why do you think certain audiences have had a really adverse, strong reaction to the character?
Heidecker: I can't really say. There isn't a tremendous amount of redemption or growth, and I think that people are conditioned to expect that. It's a type of character that I think used to be much more prominent in films and has kind of faded away. Somebody like Travis Bickle from Taxi Driver – he doesn't learn anything. There are a lot of movies from the '70s and before that center around pretty unlikable characters. And the world is full of unlikable characters. I think you can like the movie and not like the character. That should be allowed.
Filmmaker: Do you reserve any sympathy for him?
Heidecker: Sure. I think there are moments in the movie, little glimpses of a human-being in there. Before the seizure scene, for instance, when he's hanging out with (Kate Lyn Sheil's character), you get the sense that this guy is a goofball. He's trying to get laid, and he's putting on the charm.
I feel like in two years it could go either way for Swanson. He could end up more isolated and cold and hardened, or he could start to open up. There seems to be room for either of those things to happen. There's at least an interest, or a curiosity, in something beyond going through life making wise cracks and drinking and playing wiffleball.
Tim and Eric Awesome Show, Great Job!
Filmmaker: When I saw the film at SXSW, the audience was packed with people who were familiar with your work on Awesome Show. And that seemed spilled over into the first twenty minutes of the movie, where the audience was laughing at things that, if they were unfamiliar with your work, they wouldn't find funny. It set a weird tone, because the movie is almost a deconstruction of the Tim and Eric style of humor.
Heidecker: I think the film rides this line, where on one end it could fall into the incredibly pretentious camp, and on the other, it could be seen as a satire or parody of a pretentious film. It's so easy to fall into that trap, especially for us, for people to be like, "Is this just a goof on an independent art film, or is this really an independent art film?"
And it is an art film, but if you put it in the context of Awesome Show, then yeah, it's something that we might end up doing. In the same way that we might parody a cop movie, we could parody this kind of movie. But I think people should expect that (Eric and I) aren't ever going to be delivering what anybody expects. And this is just another case of that.
Filmmaker: Awesome Show took pleasure in confronting the audience with things that were unexpected or unpleasant – those very brass moments that pulled you out of the show in an almost Lynchian kind of way. And the movie perhaps doesn't go to that extreme, but it's still provoking with the audience in a similar way.
Heidecker: And I"d also add that a lot of my work is about the question of what comedy is, an exploration or dissection of comedy. In Tim and Eric, it's often comedy itself being lampooned – we put the question of what is funny and what is not up for debate. In The Comedy, I think that idea comes across in the way people joke around, and the way humor is used as both a weapon and a shield.
Filmmaker: You've created this public persona for yourself – it's hard to tell the difference between Tim Heidecker the filmmaker and Tim Heidecker the character. Is that something you find shifting as you hit the festival circuit to promote something that's more overtly dramatic?
Heidecker: Eric and I came from the Andy Kaufman school, where part of the mystery was, "Who are these guys?" So there's always been a lot of staying in character. But over time, as I've gotten a little older, that's become less important to me. I've certainly started to express myself as myself on places like Twitter.
But I'm still interested in not having anybody figure out exactly what I'm about. It's fun to keep that up. For instance, I have this persona as a standup character who's just a total right-wing Tea Party guy, and I still use my own name for that. I've always felt that to hide behind a character name was just a waste of energy. If I have an idea, it's always going to come out as Tim – whether that's Tim from Tim and Eric or just Tim Heidecker. And I think people can find the connection between all of those ideas as coming from a similar voice.
Filmmaker: With Awesome Show, you had years to develop that persona and character. But here, you created this character over a two-to-three week film shoot. Did that make for a big difference?
Heidecker: For sure. That's why Swanson is much closer to my personal self. We just decided that we were going to let him be as similar to me as possible, for the authenticity and realism of it. I think to attempt to create a character from scratch would have come across as phony, because there just wasn't enough time to build this universe.
Filmmaker: I wanted to ask about the marketing tactics. The film's teaser trailer is almost daring the audience to endure the movie. You're taking that revulsion that certain audiences felt, and using it for your own benefit. How did you guys decide on that tactic?
Heidecker: Well that was all Rick, I think. And Tribeca Film was cool with it.
First of all, I think some of those quotes are awesome, and are totally an endorsement of the film. But to me, I have a real distrust and skepticism for film criticism, especially nowadays, and I think a lot of people do too. When Billion Dollar Movie came out, we got ripped apart by a lot of people. And then I started getting this feedback that was like, "Oh that was awesome. Did you see how Roger Ebert hated your movie? Congratulations!" Like that means something. Because, it's like, "Fuck those people who think they know what's good and bad."
The Huffington Post piece is hilarious, though. That person seems like she wrote that review as she was walking out the theater. This movie, you've got to sleep on it. You've got to digest it. I think it's a little silly to draw conclusions about a film 10 seconds after you've seen it. I think that's a little confrontational. But the movie's confrontational, so I guess it's appropriate.
Filmmaker: At the SXSW screening, the first question of the Q&A was some angry woman basically asking Rick, "Why would you make a movie about this person, a fat, white, rich guy?"
Heidecker: (Laughs) I said, "I'm not fat. Dom Deluise is fat, lady." Something like that.
Filmmaker: But how do you respond when people have that reaction?
Heidecker: I say, "Why make a movie about anything?" It's an absurd question. Rick had an idea, and he wanted to make this movie, and he made it, and that's the movie he made. The question of why is like, why do anything? Why paint a picture? Why make a horror movie? What the fuck? Who cares? Just get out of the way and stop asking irrelevant questions. This movie's about something and it has something to say. And it's supposed to actually make you feel, and make you feel uncomfortable, and make you question where you are in the world. So that's her problem.
The Comedy, released by Tribeca Film, is playing in select theaters, and is available now on VOD and iTunes.
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Notes from a festival programmer: A film synopsis should never start with "The film begins when..."
A film synopsis should never start with "The film/story begins when..."
This is not only a clunky way to start a synopsis, it's wasted words as the reader should already know it's a film. Even at four words in length, the phrase is a slow burner, delaying the start of any action. You want to drop your audience in immediately.
Note that the first sentence immediately identifies the protagonists and the inciting incident that kicks off the entire film. By itself, it's already a strong introduction. It's the second and third sentences that up the ante by pulling us in. Telling us how the musicians uniquely make their escape and what out of the ordinary obstacles that escape introduces. Another strong point is that this breakdown tells us the film is probably a comedy and not a thriller without relying on adjectives like hilarious or uproarious.
A classic film summed up in 3 sentences.


While the Saudis were buying weapons from the Americans, in Yemen, the Houthis raided the Sudanese mercenaries, whose occupants were hired to reduce losses of their own armed forces.
The International Committee of the Red Cross (ICRC) is shocked by last night's attack on a civilian ship carrying around 150 passengers, including women and children, near the port of Hodeida.
Given the current state of relations with the United States, Moscow should work directly with the regional players, including using disputes between different members of the coalition, primarily KSA and UAE. The coalition is allowed to save face and declare their military victory, and its opponents to prevent the final destruction of the country and at the same time to consolidate its position and to ensure a quota in the government of Yemen.


Wellington County Paranormal Investigators (WCPI) is committed to increasing awareness of the Paranormal. As a team, through investigation and study, we continue to improve our knowledge and approaches within this field. And, in so doing so, we grow more mindful and more appreciative of the effort's and contributions of others. In the vein of "Paying It Back", we would like to assist those involved in increasing awareness of the paranormal, by providing a free forum where they can advertise their initiatives. Regardless if your initiative is local or global, free or has a cost associated with it, you are welcome to advertise here.
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Please include all information you feel is pertinent towards the successful promotion of your initiative.
Also, ensure that you include an email address should we need additional information.


text:
Treaty reformers target services veto
THE European Commission says trade in services worth trillions of euro a year is the key to the future of the world economy.
By Peter Chapman
November 22, 2000	5:00 pm
But with so much at stake, the institution is demanding radical reform of the way trade deals in the services sector – including investment and intellectual property rules – are thrashed out.
Since day one, the EU's founding Treaty of Rome has given the European Commission the right to go to international trade conferences and negotiate deals to reduce tariffs or trade barriers on goods on behalf of all the Union's members.
Both the Commission's negotiating mandate and the subsequent deals are rubber-stamped by the Council of Ministers, provided a qualified majority of member states are willing to sign up to them.
But for the intangible 'services' sector, which is far more subject to the vagaries of national culture and custom, the picture is very different – with unanimity required in the Council.
Does it still make sense, asks the Commission, to tie the EU's hands in international negotiations by relying on a 43-year-old system to govern the crucial services sector? Trade chief Pascal Lamy and his aides think not.
In a recent speech, Lamy's top official Peter Carl said it was "unthinkable that decisions in the Community interest can be taken by a procedure that was agreed in 1958". He added: "We need a substantial improvement in the procedure used to take decisions in the Council."
In a bid to tackle this problem, his boss is trying to persuade member states to agree on a new system at next month's treaty reform summit in Nice which would allow deals on services, like those covering goods, to be approved by qualified majority vote (QMV).
Under the plan, individual member states would only be able to veto negotiations in areas which would have a profound impact on vital national interests.
Likely candidates for an opt-out would be the culture and audiovisual industry – a sector considered by France as crucial to its national identity, and shipping services – a Danish and Greek priority.
But if the Commission's proposals were approved, it would still have a far freer hand to negotiate reform of international treaties, such as an update of the World Trade 'General Agreement on Trade in Services' without having to pander to each member state's special interests.
To complete the reforms, the Commission wants to make trade negotiations in all sectors the exclusive responsibility of the European Community, rather than the European
Community and member states.
This seemingly arcane difference would mean that member states would no longer be able to negotiate bilateral deals such as 'open skies' aviation agreements.
Crucially, it would also mean that every national parliament would no longer have to ratify each and every EU-level agreement individually before it can become legally binding.
It remains doubtful that Union leaders will sign up to all or even some of these changes in Nice. Member states, understandably, fear the Commission would try to sign agreements with third countries which would be unpalatable at home. "What they want to avoid is a situation where the Commission can, for example say 'the US wants us to harmonise our taxes at x per cent, therefore we propose by QMV this should happen'," explained one diplomat.
But if reform is not forthcoming, warns Peter Carl, the EU will find itself in a terrible mess in trade negotiations once it expands to take in up to a dozen new members. Achieving unanimity among 25-plus member states would be a nightmare, let alone waiting for their parliaments to sign off a deal.
Worse still, the Union will not be able to punch its real weight in a new general round of tariff-cutting talks under the auspices of the World Trade Organisation. "The Community will be weakened on the international stage," he said, adding that there would be "no chance of getting a credible agreement" in the next round.
More from ... Peter Chapman
France	United Kingdom


text:
ACEO, National Health Authority, GoI reviews performance of ABPM-JAY, ABPM-JAY Sehat scheme across J&K
SRINAGAR : Additional Chief Executive Officer (ACEO), National Health Authority (NHA), Government of India, Dr. Praveen Geedam today chaired a meeting to review the progress and performance of Ayushman Bharat Pradhan Mantri Jan Arogya Yojana (ABPM-JAY) Scheme and National Digital Health Mission (NDHM) in the UT of Jammu and Kashmir.
Principal GMC, Srinagar, Dr. Samia Rashid; CEO, AB PM-JAY, J&K, Doifode Sagar Dattatray; MD, NHM, Choudhary Yasin; Director Health Services, Kashmir, Mushtaq Ahmad Rather and other senior officers of the department attended the meeting while as Principal GMC, Jammu, Director Health Services, Jammu, Medical Superintendents of Teritiary care Hospitals, Medical Superintendents of District Hospitals, CMOs of all the districts and other concerned officials participated in the meeting through video conferencing.
Speaking during the meeting, Dr. Praveen said that Jammu and Kashmir has done exceptionally well in the implementation of scheme on the ground and a large number of populace has taken benefits from this scheme.
The ACEO highlighted that there is a scope of improvement in every field and the database of the scheme will be updated in coming months which will make the process much smooth and will help in effective implementation of the scheme.
Dr. Praveen delved upon the officers for the micro management from the ground level in order to achieve the desired objectives of the scheme. He asked them to make the process of claims smooth with a mechanism of avoiding duplication and effective checking of documents uploaded for claiming benefits under the scheme.
The ACEO further asked the officers to expand the Information, Education and Communication (IEC) activities across the length and breadth of J&K involving all the stakeholders like PRIs and other institutions so that more people get aware about this scheme.
On the occasion CEO, AB PM-JAY, J&K gave a detailed presentation on the achievements made under this scheme. He informed the meeting that as on date 49.1 lakh Ayushman cards covering 14 lakh families (70%) have been generated across J&K which is much above the National average of 59.2 %.
Div Com Kashmir inspects work progress on STPs in Srinagar
Tokyo Institute of Technology: It's Elementary: Visualizing Molecular Motion of Substituted 9-Phosphaanthracene


Can this tomato plant be saved?
Is there anything I can do to help this plant produce the roots that were lost during the replanting quicker? or is it 'unsavable'?
The parts of the plant that got the little root growth powder I had left are doing better. The leaves are all nearly gone because of yellowing and drying out. The pot is not holding water so I have been hand spraying the plant.
Last edited by skaterprincess on Sun Sep 04, 2011 7:05 pm, edited 1 time in total.
Your plant is suffering from transplant shock. Roots need to be treated very gently during the transplant process. Also, it's much harder on a plant if it is moved after it has flowered and set fruit. Plants should be settled in their final container well before they reach that point. It may drop some or all of the fruit as a result of being repotted this late. Covering the plant with clear plastic might have helped reduce the wilting, but it could also have lead to the growth of fungus.
The wilted leaves and wrinkled tomatoes are the result of the feeder roots being unable to absorb enough water to maintain the rigidity of the cell walls.
Why did you put milk on the roots? Was the plant showing symptoms of blossom-end rot?
This is the first year that I have paid attention to what chemicals/fertilizer (or really food) that plants need. I added milk because I thought I remembered that it turns to nitrogen?? I really think I had my plants messed up - it's sweet peppers that like calcium.
No need to feel embarrassed about a mistake. Everyone makes them. It's how we learn.
If your plant hasn't perked up noticeably by now, the chances are strong that it isn't going to.
Look at the posts at the very top of this section of the forum. There are several previous discussions that have been made into Stickies. I think you will find a lot of excellent information about tomato gardening in those discussions.
I haven't heard of milk as a source of nitrogen, but that doesn't mean it wouldn't be successful. I know milk is used as a fungicide and a source of calcium for plants, but for both purposes, I think it's usually mixed with water and sprayed on the leaves. All plants need calcium, btw.
As you will learn when you read the Stickies, calcium is needed to prevent blossom-end rot, among other things. There is usually plenty of it in the soil, but for one reason or another, the roots can't absorb it. That's why spraying milk on the leaves can sometimes help. That wasn't the problem with your tomato plant, though.
The other thing I am stuck on is part of the plant has come back but other parts of the plant have not. (It is a mutant as it was more than one plant to start with which after the fact I realized is why it was to top heavy for the original pot.) The part that looks like it is dying has fruit on it, does that affect anything?
I was thinking about getting a plastic tub and let the plant sit it that for awhile to get the roots going?? This idea came from the suckers that I pulled and I did an experiment, the ones that just sat in water did just as well or better than the ones sitting in soil.
Does anyone think this will work?
I wanted to give an interesting update on my poor sick tomato plant. Plants are amazing, they know just what to do.
I think it is amazing that the fruit turned color! That was all I could ask for. I will pick the fruit, I am curious to see what the inside looks like. Once the fruit is picked, I am going to compose the rest - to bad I was hoping to experiment with it this winter inside.
glad to see they have come around.
As kisal said they don't like being transplanted with fruit and flowers. Next time do it earlier of if the situation arise and you can not. It may be best to remove flowers and fruit. This is done because the plant when transplant wants/needs to produce new roots. With fruit on it the plant is battling itself to to feed both the fruit and the root.
Can F1 Tomato Seeds Be Saved to Plant the Following Year?
Tomato murder :( Can it be saved?


text:
Banks 'need fear of hell and hope of heaven', says Welby
by Madeleine Davies
GRAHAM LACDAO
WHEN the Archbishop of Canterbury took to the stage on Wednesday evening to debate "What makes a good bank?" news had just hit the City that the banker he once took to task over his response to a similar question, had stepped down.
Stephen Hester, the banker, announced that he would leave his post as chief executive of Royal Bank of Scotland in order to comply with the Government's insistence that the bank return to private ownership by the end of 2014. As a member of the Parliamentary Commission on Banking Standards, the Archbishop once accused him of giving "motherhood and apple pie" responses to his questions about RBS' obligations to society (News, 22 February).
On Wednesday night, the Archbishop declined to say where RBS might find a "good man" to replace Mr Hester. But he said that "banks, to be good, need the fear of hell and the hope of heaven, not merely the fear of penury and the hope of a larger bank account."
Speaking at the debate at St Paul's Cathedral, organised by the St Paul's Institute, the Archbishop suggested that "the biggest weakness of all in the analysis of the failure of banks to be good banks has been around understanding about human beings. We have looked at banks as though sin did not exist and redemption and salvation were not possible."
He said: "At the heart of good banks are good people. And if we want to have good banks, we have to believe in fallible people. . . If we believe in fallible people, we will work on aspects of behaviour and training that is conditioning the body, that recognise that human beings are both more fallible than a systemic regulatory system will allow, and have greater potential than our pessimism might permit."
He called on the City to undertake a "deliberate, self-designed popping of the bubble of inward-looking self-regard". For him and his wife, both London-born, it had been a "great shock" to return to London, a "buzzing" place whose wealth was not replicated in most of the UK and which was in danger of developing "a culture of passing by".
"In a dystopian mood, it would be possible to imagine a future in which . . . the needs of the utterly cosmopolitan population are served by the disenfranchised residents of the surrounding countryside, what in Sparta were called the serfs," he said.
An alternative was the "possibilty of wealth as life-giving water, spreading through all the channels of our national and global economy from the great well of talent and prosperity that is London". Differences in wealth and potential could be eliminated, he said, but not without good banks.
The debate was also addressed by Antony Jenkins, the group chief executive of Barclays, who, like Mr Hester, had been interrogated by Archbishop Welby in Westminster. He admitted that "being told off" by the Primate was "not a comfortable experience".
He began with a defence of capitalism. It had "lifted millions out of poverty", he said, and it was unlikely that the debate's venue could have been built without debt.
Nevertheless, he agreed with the verdict of the Church Commissioners that Barclays had "repeatedly let down society with its conduct" ( News, 17 May). Banks had become "too focused on the short term" and "forgot what our role in society was and who we were there to serve".
He argued that there was "no contradiction between doing well and behaving well", but accepted that many would be "sceptical" about his comments: "Capitalism and banking with a moral compass is our mission at Barclays, and we are happy to be judged by how we succeed."
Another panel member, Laura Willoughby, chief executive of Move Your Money, described the relationship between individuals and their bank as a "hostage situation", and urged the audience to take responsibilty by moving their money: "The more the banks rely on our inaction, the more we can be certain that they won't take any."
The Archbishops revealed at the start of the debate that the final report of the Parliamentary Commision on Banking Standards had been completed just twenty minutes earlier. The Commission was still in purdah and the audience would find no "hidden clues" about it conclusions in his comments.
Listen to Archbishop Welby's talk here.
www.stpaulsinstitute.org.uk
Abbey to mark 1914
UK news in brief
Cornish seagulls swoop on charity fund-raisers
Chartres 'builds Jerusalem'
Wanderers drop loans firm after protests
New course for media
WorldCommentBooks & Arts


text:
Q: Memory Allocation with Adjacent Arrays I was fiddling around with two arrays in C, trying to get one of them to invade the memory space of the other. As a beginner I understand the compiler automatically allocates memory space for the arrays in my example, but how are these memory addresses chosen? For example, in the below code (compiled by my browser on c++.com website) the addresses for numbers[] and stealth[] respectively are:
0x75fbb51092c0
0x75fbb51092b0
which I calculated were 16 bytes apart. Is this some safety measure so that that one array doesn't enter another's space?
// more pointers
#include <iostream>
using namespace std;

int main ()
{
  int numbers[5];
  int stealth[1];

for (int i=0;i<6;i++){
    if (i==0){
        stealth[i]=9;
    }
    else {
        numbers[i]=i;
    }
  }
  int * a;
//  b=numbers;
  a=numbers;

  cout << "value at 0 index for numbers: "<< *a << endl;
  cout << "address: " << a << endl;

  a=stealth;

  cout << "value at 0 index for stealth: "<< *a << endl;
  cout << "address: " << a << endl;

  return 0;
}

++++
EDIT
++++
Thanks for your input. After some further testing I set pointer to an array to an integer's location. Then I iterated through the array and printed out the memory address at every index value. Yet, the index at the beginning of the array has a different address than the one had set to the integer earlier. Any ideas why? I pasted new code and output below:
// more pointers
#include <iostream>
#include <string>
using namespace std;

int main ()
{
  int numbers[5]={1,2,3,4,5};
  int alien=6;

  int * a;
  int * b;
  b=numbers;
  a=&alien;
  b=a;
  cout << "address of start of array numbers: " << b << endl;
  cout << "address of alien: " << a << endl;

  for (int i=0;i<5;i++){
    cout << &numbers[i] << endl;
    cout << numbers[i] << endl;
  }
  return 0;
}

OUTPUT
address of start of array numbers: 0x79ab503a591c
address of alien: 0x79ab503a591c
0x79ab503a5920
1
0x79ab503a5924
2
0x79ab503a5928
3
0x79ab503a592c
4
0x79ab503a5930
5

A: Any variables (other than unions) that you allocate on the stack will have their own storage, that is a guarantee of the language. The address is chosen partly by the compiler but mostly by the operating system. The higher part of the address (amount varies by system but usually at least 0x1000) will be chosen by the OS whole lower parts will depend on the compiler.
The only way you would get an array to invade the space occupied by a different variable would be if you were to mess around with pointers and many of those operations would result in undefined behavior.

redpajama_set_name: RedPajamaStackExchange


text:
Release Blitz: SEXIEST BILLIONAIRE by Sierra Cartwright
An exclusive private society of the world's most powerful ambitious gentlemen
Sex, Secrets, and Intrigue
Sexiest Billionaire
She's his friend's daughter. Off-limits to a man like Jax.
Jaxon Mills is stunned—then furious—when sees his biggest investor's daughter at one of the most exclusive clubs in New Orleans, dressed in a scandalous outfit and wearing an inviting smile. The tempting woman with the compassionate heart is supposed to be tucked away at grad school, where's she safe from men like him.
Willow Henderson has one escape from her overprotective family—the French Quarter. There, she can be anonymous, even if only for a short time. But she never expects to come face-to-face with Jaxon, a sexy self-made billionaire Dom whose arrogance is matched only by his bank account.
Jax, an avowed workaholic determined to outrun his troubled past, has never allowed a woman to distract him. Until Willow. And when he discovers she's a virgin, it's more than a dominant urge that flares. It's an honorable instinct he hadn't known he was capable of.
He will do anything to make her his.
***This story contains plenty of steam! It's a standalone story with a feel-good happily ever after. ***
Sexiest Billionaire's Buy Links
Amazon US I Amazon UK I iBooks I Nook I Kobo
Billionaire's Matchmaker
Arriving June 26, 2018
About Sierra Cartwright:
USA Today Best-Selling Author, Winner of the 2015 Best BDSM Book of the year (Bind), 2015 Reader's Choice Best Erotic Romance (Bind), 2015 Golden Flogger (Crave), 2014 LASR Book of the Year award (In The Den), 2013 Best BDSM Book of the Year award (Over The Line), Golden Flogger Award 2015 nominee for her books Command, Bind, and Brand, Sierra was born in Manchester, England where she spent her early years traipsing through castles. After living in Denver for a number of years, the internationally acclaimed author now resides in Galveston, Texas. She loves the way history blends with Southern manners (being called "sugar" is an experience unto itself). She invites you to join her on a sensual journey where the limits are explored and expanded.
Connect with Sierra Cartwright
Website I Facebook I Pinterest I Twitter
once upon an alpha Release Blitz SEXIEST BILLIONAIRE by Sierra Cartwright
Thanks for the Feedback please come back and visit again!
Blog Tour: Revenge on the Rocks by Jenna Jacob
When Gina Scott kicks the town bully out of her bar, Nate Grayson glimpses the fragile woman under her tough façade. Though he wants her, she's twelve years his senior. She'll never take him seriously, right? Wrong. That night after closing, he loses his virginity—and his heart—to her. Since they live in a small town and tongues wag, Gina insists they keep their relationship a secret. He agrees…for a spell. But six months later, Nate is ready to tie the knot. After an abusive marriage, Gina Scott diligently protected her jaded heart for a decade. But after just one night, Nate burrows under her defenses. He might be inexperienced, but he's all Alpha and more than capable of turning her inside out. She aches to surrender her heart and say yes to their future…but she's keeping a dark secret—one that would destroy the happily ever after Nate deserves. She resolves to enjoy their shared pleasure for as long as it lasts while bracing for the day he walks away. But before he can convince Gi…
Blitz & Giveaway: Tethered by Carlyle Labuschagne
Title: Tethered Author: Carlyle Labuschagne Genre: Supernatural Suspense Hosted by: Lady Amber's PR
Blurb: A girl tethered to a serial killer by heart leads FBI to the undiscovered bodies of The Devil's breath victims. Tethered follows two sisters, Willow and Raine Viviers alongside two rogue FBI brothers on what seems like an impossible task to solving a dead end case. With no leads, and a corrupt government cover up, their time is running out to stop the spread of a Serial Killer Cult before another victim is claimed. But they have a secret weapon... Willow is a young adult who has just undergone a heart transplant who's trauma has changed her, she's gained a strange supernatural gift - she can see into the heart of the Devil's Breath Killer. She not only feels the serial killer's urges, knows his thoughts, but somehow gets visions through the eyes of his victims too. These visions are chaotic, menacing and evil, and Willow can hardly make sense of her own reality…


Good Monday morning, golf fans. Hope your weekend was somewhere between Phil Mickelson's and Bleacher Report's.
With the so-called Silly Season in full swing, we have plenty of winners to congratulate this week (I'll see your "silly" and raise you $9 million, says Phil Mickelson).
First up, a duo…At the World Cup of Golf — which is not exactly on par with the World Cup of soccer — Thomas Pieters and Thomas Detry of Belgium took the trophy.
And on the European Tour, it was the week of Aaron Rai.
The peerless Ho-sung Choi won on the Japan Golf Tour.
In a fitting post-mortem of The Match, Geoff Shackelford looked at the great, the good, and the bad from Shadow Creek.
The Great…Charles Barkley: He should have been on the full broadcast, in hindsight. He got right to the point as Tiger and Phil struggled horribly to read Shadow Creek's greens. He jousted as only he can with Justin Verlander's Tweets, too. But sadly, Barkley also was not around for the last couple of hours to put a bow.
The Audio: Turns out, a feed of just open microphones would have been enough for most people. Phil was in hard sell mode early but once he settled into a normal round of golf, basically narrated the proceedings. Tiger chimed in with enough to make a player-only feed functional had that been an option.
The Bad…Announcers Talking Over Players: Everyone was guilty at some point and I'm sympathetic to the cause as this was not a normal broadcast crew, not a normal match and an unprecedented amount of sound for a sporting event to take in.
A few thoughts from the "golf on TV" guru, Martin Kaufmann.
Kaufmann makes a number of points as to what ought to change going forward. Here are a couple.
7. International Team turnaround ahead?
"I'm really lucky to be playing right now," she told him. Against these players, on these venues, for this kind of money.
The delayed results of the Haney Project? Single-minded determination? The intercession of the golf gods? Whatever the cause, it looks like Charles Barkley's full-body convulsion of a golf swing now resembles, well, a golf swing.
Check out Chuck's action here (c/o Alison Lee) .
Rounding up golf's loudest mouths is all and good, but it is the audience (the paying customer all-important to the entire golf industry) who will determine success or failure of on-air and in-ink events and round-ups.
So I suggest you tap in to Tweeter and other SM and give us a fair sampling of opinion before, during, and after the Match and other events. (Did public opinion change pre- to post- event? Indeed it did–Breed is hitting that topic right now.) Columnists want readers and often their opinion's are diluted with promotion tactics. Let's hear the people, and that, Ben, would help your presence and persona on GolfWRX, along with your traditional reportage.
I say all that because I "feel" a trend in golf toward even more elitism and commerce. Increasing sales doesn't grow the game.


text:
https://www.foodsforbetterhealth.com/chumlee-returns-pawn-stars-actor-focusing-fitness-season-13-despite-replacement-rumors-21475 Chumlee Returns to Pawn Stars? Actor Focusing on Fitness for Season 13 Despite Replacement… Farah Shaikh Foods 4 Better Health 2016-10-27T12:30:34Z 2016-10-27 12:21:28 Celebrity Diets https://www.foodsforbetterhealth.com/wp-content/uploads/2016/10/Farah_Chumlee_271016-150x116.jpg
Home > Celebrity Diets > Chumlee Returns to Pawn Stars? Actor Focusing on Fitness for Season 13 Despite Replacement Rumors
Chumlee Returns to Pawn Stars? Actor Focusing on Fitness for Season 13 Despite Replacement Rumors
By : Farah Shaikh
Photo Credit: Ethan Miller / Staff / Getty
The whole cast of Pawn Star season 13 has started filming except for one person, Chumlee. Austin Lee Russell, otherwise known as Chumlee, has not been seen on set and there are rumors going around that he will be replaced.
He has been involved in many legal cases this year, which may have brought his run on Pawn Star to an end. Though Chumlee posted on social media that he would return to the show in the upcoming season, reports say that showrunners have already discontinued him from the show because of his legal drama.
Chumlee has resumed working in the pawnshop as a customer assistant. It is being predicted that Chumlee's brother, Sage Russell, will join the show.
Chumlee's Arrest
Looper reports that on March 09, 2016, police searched Chumlee's house to investigate a sexual assault charge. An employee of the Gold and Silver Pawnshop filed a case against him and later dismissed it as there was no evidence of the claim.
In his Nevada home, the police found marijuana, methamphetamines, and guns. Chumlee was then arrested and later released on $62,000 bail. He faces 19 drug-related charges based on materials found during the raid.
According to the police report, a dozen guns were found during the search, some of which were loaded. Out of the dozen, just four were registered to Russell.
The report further mentions that the drugs and paraphernalia were found in large quantities, which made it seem like he was packaging and selling the controlled substances.
His lawyers came up with a deal to put him on a three years' probation. He also attended counseling sessions for sex offenders.
Chumlee's Weight Loss
Chumlee is trying to make his life better by offering to help local charities. He's recently started to focus on his health and to lose weight.
While some of the Pawn Stars adopted a quicker way to shed pounds like surgery, Chumlee relied on a Paleo diet and ate clean.
He follows a low-carbohydrate and high protein diet. He eats lots of fresh veggies and meat and has abandoned processed and junk foods. He also avoids refined carbohydrates including sugar and flour. Soon after he got rid of the processed foods, he added them back to his diet in moderation.
When he started to diet, he weighed 320 lbs.—he now weighs 225. He happily advises his fans on social media about his methods for weight loss. Some of his advice includes making "little changes" and the following:
Don't diet change your eating habits for ever. https://t.co/vyx6C5aSAt
— Austin Russell (@chumlee_) July 6, 2016
Staff, L., "What we know about Pawn Stars' Chumlee," Looper web site;
http://www.looper.com/11396/know-pawn-stars-chumlee/, last accessed October 27, 2016


text:
Bonifacio (en idioma corso, Bunifaziu) es una comuna francesa situada en la circunscripción departamental de Córcega del Sur y en el territorio de la colectividad de Córcega. Tiene una población estimada, en 2019, de 3192 habitantes.

Es una de las localidades más antiguas de Córcega y uno de los pueblos más pintorescos de la isla y de la costa mediterránea en general.

Geografía
Situada en el extremo sur de Córcega, es la comuna más meridional de la Francia metropolitana. Se encuentra enclavada en una pequeña península rodeada de acantilados. Su fortaleza milenaria, sus monumentos históricos, sus casas bajas y calles estrechas y empedradas se ubican a 70 metros sobre el nivel del mar y se asoman a la costa como miradores.

Al sur, el estrecho de Bonifacio separa Córcega de la isla italiana de Cerdeña.

El suelo es de naturaleza calcárea, hecho excepcional en Córcega, donde suele ser granítico.

Cuenta, incluso, con un barranco con apariencia de fiordo de 100 metros, lo que le otorga un puerto natural. Pero, sin duda, uno de los mayores atractivos turísticos de esta localidad es su ciudadela amurallada, que data de la época genovesa.

Demografía

Hermanamientos
  Morzine (Alta Saboya)

Referencias

Enlaces externos

 Sitio web oficial
 INSEE

Localidades de Córcega del Sur
Localidades portuarias de Córcega

redpajama_set_name: RedPajamaWikipedia


text:
Bella: Local film production challenges
In the wake of the African Movie Academy Awards (Amaa) nominations that were hosted in the country recently, CHEU MITA spoke with writer and film director, Tawonga Taddja Nkhonjera, about the making of his soon to be premiered film B'ella which focuses on the life of Form 3 students at Nankumba Community Day Secondary School specifically a 17-year-old girl called B'ella.
Progress on the film, so far?
Filming was completed, and now we are in the post-production phase. We are also working on the soundtrack to be done by recording artists from Dikamawoko Arts, Muhanya and myself. The soundtrack will be guitar based, predominantly, and we will also include the mbira, finger piano to bring in an African sound.
Of the filming process…
We always attracted huge crowds whenever filming and so to maintain silence when filming was a big problem.
In the example of the film City of God, we decided to make B'ella a community project and so we used the actual students from Nankumba Secondary School as our actors.
Who is involved in this project?
The primary players in the film are a Malawian NGO called boNGO and Dikamawoko Arts
What challenges did you meet?
The film was shot between December and January and unpredictable weather posed big problems in keeping with schedule. We were missing out on cinematic expression because of the lack of professional film equipment such as dollies, slider, jibs, specific lighting equipment, lenses, etc.
Another challenge was that the filming process takes a long time, from pre-production to principal photography and we lost some actors along the way like one got pregnant.
Tell us a story from the set.
We had staged a funeral scene and members of the village joined the procession to the grave crying, asking who had died. It was a little awkward to tell them that we were just acting out a part in the film. But they eventually understood and we all laughed about it.
When do we expect to see the film, B'ella?
The premiere would be around late May.
What should people expect from B'ella?
A film that will make them smile, laugh, wonder, gasp in awe at the beauty in some of the landscapes of Malawi; a film that will draw tears, put them on the edges of their seats… it is a full feature with all the drama that life brings. The full Monty, so to speak.
What are the plans for B'ella?
We will have the world premiere of B'ella in Blantyre on a date and venue yet to be confirmed. The international premiere is slated for the International Film Festival Karlovy Vary in the Czech Republic in July. We will then later embark on a project called B'ella in Schools.
Put PSs, directors on contracts—Ecama
Clean your house, CSTU told


Want to create a stylish, modern but warm interior to your home but a bit stuck as to how to get it on a budget? No worries as these five top insider tips will help you make the smallest changes that bring the maximum impact to a space.
It is a task you have probably been avoiding but it has to happen! The first thing you need to do in your quest to give your home interior a modern and stylish look is to streamline.
Over the years we do gather and collect things. Unless you have somewhere to put all these things, it can be tough giving your home a fresh, modern appeal with so much 'stuff' cluttering the eyeline.
But here's the thing: getting rid of things can be a tough call. Many people struggle within ditching things that they feel hold so many precious memories. But they still want a fresh look to a room.
It isn't a case of being ruthless but understanding how these items can be used to add something to the room. What is the best way to display them?
* Once you reduced your items (if you can), consider the best way to make these items shine in a space and the best way of displaying them. For example, if you are an avid collector of books, can they be arranged in a way that clusters similar colours together or similar heights and sizes of books?
Clearly, unless you have the budget for a complete re-vamp of a room, the likelihood is some or most of the furniture is staying. But if you can stretch to it, replacing some items with modern, stylish ones is a great way of adding a stylish hint to a space.
However, modern doesn't have to mean quirky. It can mean a modern colour or fabric choice, as well as a play on an iconic design a bit like an angel chair. A Scandinavian design, it is a relaxed version of an armchair, always so straight and somehow constricting. But this more open and relaxed design that welcomes you into its folds.
* Choose the shape and design of an item so that it sits well with your current sofa and other items. If you want it to be completely different, make sure it is but if you want them to blend together, choose carefully so you get a cohesive look to your living space or interior design.
However, if your budget is super-tight, ditching your furniture may not be an option but there is s solution: soft furnishings and artwork.
Sometimes, the pieces that add the most glamour and a modern feel to a space is the use of fabrics and materials, as well as art work for the walls. This doesn't mean however, you need to turn the living room into the Tate Modern.
Art is in the eye of the beholder and there are some great examples of modern art work that you can buy to replace older, jaded pieces.
Like your overall interior design style, choose similar items and shapes so that there is a sense of cohesion between everything. For example, if you prefer curves over angles, opt for art work and sculptures that use curves, circles and roundness within them. Or why not opt for quirky, almost cartoonesque wall art of animals and nature, and link it all together with modern, fresh and appealing soft furnishings?
* Give old photos and artwork a new lease of life with a new frame. Arrange in a symmetrical pattern on the wall for maximum effect.
If there is one thing that breathes fresh air into a space it is colour. As with most interior design trends, colours trends change from year to year and, in some cases, from season to season.
If you want a fresh modern appeal, why not see which colour scheme works with your current furniture/ take a look at colour trends for 2017 and beyond?
* Don't be frightened to experiment with wall colour as it is one of the easiest and quickest things you can change about a room.
Modern design suggests many ways in which you can increase the appeal of any room in your home. But the one design that people are really taking to is the increased use of patterned tiling.
If you want to inject an air of the modern in your bathroom or your kitchen, rather than sticking with a painted feature wall, opt for a tiled wall instead. Choose patterns in the same shade or colour and mix and match to your heart's content! The results are stunning!
Which of these ideas will you try?
Sloane & Sons have a range of chairs that make dressing a living room, dining room, bedroom or any room in the home super-easy. This is because they have many years of experience in finding the most stylish items for their customers, and at the right price.


text:
Police News for Thursday, Aug. 18, 2011
The Milford Daily News
Millville man arrested on warrant
MILLVILLE - A Millville man was arrested at 2:15 a.m. yesterday on Central Street, police said.
Andrew James Dubois, 25, of 40 Central St., was arrested on a warrant from New Bedford District Court, police said.
R.I. man arrested on warrant
FRANKLIN - A Rhode Island man was arrested at 1:24 p.m. Tuesday after a traffic stop at 862 King St., police said.
Jeremy Giguere, 23, of 2060 Bronco Highway, Harrisville, R.I., was arrested on a warrant from Blackstone Police, police said.
Franklin woman arrested on warrant
FRANKLIN - A Franklin woman was arrested at 1:45 p.m. Tuesday at her Buena Vista Drive home, police said.
Maggi E. Roy, 30, of 23 Buena Vista Drive, was arrested on a warrant from Wrentham District Court, police said.
Franklin man arrested on warrant
FRANKLIN - A Franklin man was arrested at 5:32 p.m. Tuesday at the police station, police said.
Michael T. Howard, 23, of 151 Summer St., was arrested on a warrant from Franklin Police, police said.
N.H. man arrested on warrant
FRANKLIN - A New Hampshire man was arrested at 11:53 p.m. Tuesday at 847 West Central St., police said.
Bradford D. Booth, 52, of 17 South Shore Drive, Pelham, N.H., was arrested on a warrant from Erving, police said.
Woman injured in Mendon crash
MENDON - A woman was injured in a car crash on Cape Road in front of Lowell's Restaurant yesterday, police said.
Barbara Ventrella, 58, of 12 High St., Bellingham, was driving a black 2002 Honda Civic around 8 a.m. when she collided with a vehicle driven by Kiernan Joliat, 29, of 37 Moore Ave., Franklin, police said.
One of the women was sent to Milford Regional Hospital with minor injuries, police said.
Women sent to hospital after Mendon crash
MENDON - Two women were involved in a car crash at the intersection of Main and Providence streets yesterday, police said.
Sandra Digirolamo, 61, of 110 Taft Ave., Uxbridge, was driving a black 2003 Honda Pilot around 12:03 p.m. when her car collided with a 2002 black Honda Civic driven by Paige Smith, 33, of 3 Bernard St., Webster, police said.


The Mexico GPS Atlas is a downloadable GPS map set for your Garmin receiver. Features include routing, topography, city plans, off road trails and tracks, PEMEX gas stations, major highways and roads, railroads, unpaved roads and some trails, National Parks and Biosphere reserves. Please note that the download will not take place until you have submitted your unit ID and an unlock key has been generated.
Includes the locations of thousands of cities and topography at 100 meter contour intervals.
Includes 280,000+ towns and rural locations and an extensive points of interest database including geographical features such as beaches, mountains, lakes, dams and rivers.
City mapping: Aguascalientes, Colima, Tuxtla Gutiérrez, Durango, Chilpancingo, Morelia, Tepic, Ciudad Victoria, Tlaxcala, Xalapa, Zacatecas, Saltillo and Culiacán.
Mexicali, Tijuana, Tecate, Rosarito, San Felipe, Ensenada, Cd. Constitución, San José del Cabo, Cabo San Lucas, La Paz, Campeche, Torreón, Chihuahua, Distrito Federal, Cd. Lerdo, Gomez Palacios, Guanajuato, León, San Miguel de Allende, Acapulco, Pachuca, Guadalajara, Puerto Vallarta, Cuernavaca and Jiutepec.
In México State: Atizapán, Tlalnepantla, Naucalpan, Huixquilican, Ecatepec, Nezahualcoyotl, Cuautitlán, Cuautitlan Izcalli, Tultitlan, Coacalco, Toluca and Valle de Bravo.
Monterrey, Oaxaca, Puebla, San Andrés Cholula, San Pedro Cholula, Querétaro, Cancun, Cozumel, Playa del Carmen, Chetumal, San Luis Potosí, Mazatlán, Hermosillo, Puerto Peñasco, Villahermosa, Veracruz and Mérida.
Urban points of interest such as hospitals, government buildings, shopping centers are included as well as over 1500 PEMEX gas stations along the Mexican highway network. International and state boundaries, lakes, rivers, national parks are also included. Contours at 50 meter (164 Ft) for the Baja Peninsula and 100 meter (328 Ft) interval for the remainder of the country. Requires a MapSource product or MapSource Trip & Waypoint Manager to install in a Nuvi or StreetPilot. The map can also be supplied on an SD card unlocked for your receiver. Compatible with almost any Garmin receiver. Searching capability varies with with model of Garmin product. A sample file is available to test in your receiver. Software is non-returnable. 180MB download (broadband recommended).
Submit your GPS Unit ID# at the final check out screen to speed order processing. Here's how to retrieve it from the GPS (ZUMO, NUVI AND STREETPILOT SERIES) 1-Turn the GPS on. 2-Select the Configuration menu (wrench icon). 3-Select SYSTEM (or SETTINGS then SYSTEM on the 200/250 Nuvi). 4-Select the ABOUT option where you will see the GPS ID number.
Handhelds - Etrex, 60CSx, 76CSx, etc.: 1-Turn on the GPS. 2-Select the Configuration menu (wrench icon). 3-Select SYSTEM. 4-Press the MENU button. 5-Select Software Version. The GPS ID will show in the lower line. Call with any questions.


text:
https://www.nationalgeographic.com/expeditions/destinations/north-america/journeys/california-national-parks-tour.html
North America Trips
Natural Highlights of California
Set out on a nine-day quest through some of California's greatest national parks. From the arid, sun-scorched landscapes of Death Valley to the astonishing giant redwoods of Sequoia National Park and Yosemite's awe-inspiring panorama of granite domes, this adventure covers a lot of ground—and almost every type of terrain imaginable.
Day 1: Las Vegas
Accommodations:Golden Nugget - Gold Tower(weekday) (or similar)
Day 2: Las Vegas/Death Valley National Park
Leave the glitz and glamour of Las Vegas behind and travel to Death Valley National Park — the lowest, hottest, and driest place in North America. Marvel at the extremes of this landscape as you pass mountains, valleys, badlands, salt flats, dunes, and more.
Accommodations:Furnace Creek Ranch (or similar)
Day 3: Death Valley National Park/Yosemite National Park
Before leaving the park, make a final stop at Mesquite Flat Sand Dunes. Then sit back and enjoy the views on this full day drive via the mountain town of Bishop and across the Sierra Nevada Mountains of California, along the famed Tioga Pass and through Yosemite Valley in the National Park.
Meals Included:Breakfast, Dinner
Accommodations:The pine resort (Weekend) (or similar)
Day 4: Yosemite National Park
With our CEO, explore stunning Yosemite National Park in the High Sierra. Explore on foot to view majestic waterfalls, crystal clear lakes, lush green meadows, and walk among pristine groves in Yosemite. Keep and eye out for glacial erratics, rock climbers and the diverse wildlife, including black bears, within the park.
Day 5: Yosemite National Park/Sequoia National Park
Depart early and walk through California's Sequoia National Park alongside a naturalist. Learn about these impressive giant trees and opt to enjoy a picnic lunch on the trail. Drive to Big Tree Trail for an afternoon hike and learn about how National Geographic deeded tracts of giant trees in the heart of the park to the National Parks Service for safekeeping. This evening, we return to the park for an evening of stargazing with an expert from the Sequoia Parks Conservancy (SPC).
Accommodations:Wuksachi Lodge (or similar)
Day 6: Sequoia National Park/Monterey
Depart the Sierra Nevadas and travel from one of California's mountain ranges to the other. Reaching the waters edge, stop to view elephant seals at Piedras Blancas Elephant Seal Rookery before driving north on the PCH, the famous Pacific Coast Highway. Stop along the way for lunch in a little seaside town. Marvel at the dramatic vistas as the waves crash into where the cliffs meet the shore. Continue through Big Sur, past famous bridges and lighthouses, get out and stretch and even opt to feel the sand between your toes. Enjoy the day soaking in part of the most beautiful coastline this National Scenic Byway has to offer en route to Monterey.
Accommodations:Casa Munras Garden Hotel & Spa (or similar)
Day 7: Monterey
Visit the Monterey Bay Aquarium on a tour specially arranged for National Geographic Journeys travellers. Get an inside look at the workings of this world-class organization and find out how the Aquarium's mission aligns with that of National Geographic. After, enjoy a free afternoon. Opt to go whale watching, try the famous clam chowder, walk or bike the Monterey Bay Coastal Trail or wander historic Fisherman's Wharf and Cannery Row.
Day 8: Monterey/San Francisco
Continue on a scenic coastal drive along the Pacific Coast Highway to San Francisco for our final evening. Catch a glimpse of the Golden Gate Bridge on the way into one of America's most popular cities. Opt to take a cable car ride over the steep hills or explore the city by bicycle.
Accommodations:Le Meridien San Francisco (or similar)
Day 9: San Francisco


text:
«Зима» () — картина латвійського художника-імпресіоніста Вільгельма Пурвітіса, написана у 1910 році. Художник розробив власний стиль, близький як до імпресіонізму, так і до північного модерну. Йому особливо вдавалися весняні та зимові пейзажі.

Опис
Картина виконана олією на полотні з розмірами 72 х 101,3 сантиметрів. Картина «Зима» знаходиться в колекції Латвійського Національного художнього музею в Ризі.

Зображений сніговий пейзаж з половиною крижаної річки, вертикальні берези та промені вечірнього сонця.

«Зима» належала «Королеві преси» Латвії, найбагатшій жінці Європи Емілії Бен'яміньї, з маєтку господині у 1954 році картина потрапила до Національного музею. У 1998 році спадкоємці офіційно передали полотно музею. З того часу відбулося декілька закордонних виставок: у Квіринальському палаці, Брюсселі, Каунасі, Києві, Люксембурзі, Москві, Таллінні.

Посилання

Література
 Kļaviņš, Eduards. Vilhelms Purvītis. Neputns. 2014. gads. Rīga.
 Lamberga, Dace. Vilhelms Purvītis. Grāmatu sērija par izcilām personībām Latvijas kultūrā un mākslā. Mūzikas un mākslas atbalsta fonds. 2012. gads. Rīga.
 Kļaviņš, Eduards. Sastādījusi Inese Riķe. Vilhelms Purvītis. 1872—1945. Neputns. 2000. gads. Rīga.

Картини 1910
Зима


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Custom printed votive candlepower unit holders are commonly used since wedding favors and these types of favors are designed according to the concept of the the wedding. If you are planning to have a beach themed wedding, couples decorate their wedding reception corridor and parties with exotic décor from palm trees, ocean shells, umbrellas and flip flops. Votive candle holders provide the right lighting for a beach front themed wedding. Votive candlestick holders can be accessorized with sea shell candles, starfish motives and even sailboats pictures can be imprinted on the holder with a special message.
Nemiri - 35 fascinating japanese garden design ideas gardenholic. 35 fascinating japanese garden design ideas a japanese inspired garden can be perfect for a small space here are 35 simple design and plant ideas to create the look. 35 fascinating japanese garden design ideas page 5 of 35. 35 fascinating japanese garden design ideas a japanese inspired garden can be perfect for a small space here are 35 simple design and plant ideas to create the look 30 backyard & garden fence decor ideas are you in need of a fence that looks great? maybe for your backyard, or around your garden, or maybe it is an entire perimeter fence. Fascinating rustic garden ideas. Fascinating rustic garden ideas rustic garden design it yourself fascinating rustic garden ideas a person that has just started their adventure with gardening and garden decor, and is about to arrange the garden by themselves might not be so enthusiastic at first. Fascinating garden decorating ideas decozilla. Fascinating garden decorating ideas by shalini � march 6, 2014 and one shouldn't neglect to decorate or at least invest in a good fencing design regular wooden, or metal fencing are very common and there is nothing in it, but you can make the usual look unusual by decorating them tags: garden decor ideas outdoor garden decor. Garden decor: fascinating garden decoration with various. Fascinating garden decoration with various big plant pots: do you wanna place of cream marble home flooring ? it works for you to keep some stuff for accessories garden decorating it is additionally can be placed square tapered black granite big plant pots garden and rectangular dark brown stone fiberglass big plant pots in wherever you need such as in the garden decor. Popular of backyard garden design ideas 20 fascinating. Popular of backyard garden design ideas 20 fascinating backyard garden designs top dreamer backyards, one of one of the most essential yet most ignored sections of your home however, they could prove to be great utility areas, if developed & handled well. 14 fascinating diy ideas for decorating garden fence. 14 fascinating diy ideas for decorating garden fence you can draw on the fence, you can attach interesting pots, attach colorful lights, etc there are many creative ideas that you can implement in your garden, you just need to find your favorite one 15 cute handmade easter pillow designs for a jolly seasonal decor. Fascinating backyard ideas on a budget page of very cool. Fascinating backyard ideas on a budget page of very cool best decor images pinterest lazy summer decorating easy gardening tips and diy projects days image is part of stunning patio decorating ideas smartrubix's gallery tags in this image are bamboo garden fence design, bamboo garden images, garden designs without grass, home garden pictures, modern front yard designs, modern garden ideas for. 36 fascinating rustic garden ideas. Fascinating rustic garden ideas a person that has just started their adventure with gardening and garden decor, and is about to arrange the garden by themselves might not be so enthusiastic at y people ask friends and family for advice, read books, articles, and magazines about garden decorating. 34 best vintage garden decor ideas and designs for 2019. Vintage garden design is a growing trend for outdoor living spaces incorporating fun antique pieces from inside the house into your yard gives it a unique look no one else on the block will have this list of 34 pretty vintage garden decor ideas has everything you need to take your outdoor space from boring to gorgeous.


Last week saw a couple of established job board players do something new.
.Jobs launched their new job seeker audience targeting platform. The organization best known for their career-focused domains and websites created the platform to meet the needs of companies frustrated with current job board services.
The service consumes the open positions of client organizations, categorizes each position, and matches open positions to 500+ unique job seeker audiences. The newly mapped positions are then distributed to the career websites whose visitors are most correlated to the position.
With Third Page, Ladders members are presented with optional questions to "tell employers more about [themselves]", and respond to as many or as few as they like. The member's responses are added to their profile, in addition to their full resume and contact information, and are then made viewable to interested Ladders recruiters. The average Ladders Third Page user has answered 125 total questions, with a total of 1.5 million question responses recorded since Third Page's beta launch in early May 2018.
I pass this news on for other job board owners with a message. You need to keep trying. Though the above news isn't earth shattering at least these sites are attempting to stay relevant. In this industry established boards that don't change over time are doomed to lose traction. So whether its a redesign or trying a new product you need to keep trying. The internet business waits for no one.
Thanks, as always, for the latest scoops!


text:
All News Your Way
MediosIndependientes - All News Your Way
Apple's Mac Pro and Pro Display XDR available in the US starting at $5999 and $4999 respectively
NewsLaunches
By Joel Oquendo	 Last updated Dec 16, 2019
Apple just announced a few days back that they are finally making its latest Mac Pro and Pro Display XDR available for customers. Now, we know that these products will not be best suitable for most customers but they are some specific customers. These customers are people who have tasks such as video editing for movies and other colour-accurate tasks. Now, we know that Apple already sold a powerful Mac Pro but the latest one is supposed to be plenty more powerful.
Talking about the Mac Pro and Pro Display XDR, we first saw them announced at the WWDC conference with cheese grater design rather than the trashcan design of the previous version. It is also known that there was a controversy regarding the Pro Display XDR as Apple announced that its stand will cost you a $999 more. This meant that Apple was not bundling the monitor's stand with it but selling it separately. So if you want to have the monitor on your desk, you need to buy a stand compulsorily. Otherwise, you only have the option to Vesa Mount it on the wall which might not be suitable for everyone.
We also knew that the Mac Pro started for $5999 and the Pro Display XDR was starting at $4999 respectively. However, we now have the prices of other options to upgrade the products as they are available to order. So if you want to have the highest variant of your Mac Pro then you will have to pay $52,500 which is even more than a high-performance Tesla Model 3. On the other hand, there is a Pro Display XDR with different glass material which costs $1000 more than the standard version. On the other hand, you can also buy the wheels for your Mac Pro which will set you back $400 but they will give you the convenience of rolling the PC around rather than lifting it which is quite heavy.
Joel Oquendo
Joel is a technology passionate, looking forward to imparting the spectrum of his insight and verdicts on the 'Technology-driven world' of today. He plans to take Medios Independientes forward with consistent support from you readers, friends, and family! You can reach him at joeloquendo@mediosindependientes.org
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Direct flights have attracted increasing numbers of visitors to the most scenic region of northern Spain. Asturias airport is perfectly located for enjoying the best of this idiosyncratic and fabulously picturesque Spanish principality. The airport is 14km from Aviles, 40km from Gijon and 47km from Oviedo. To the east is the Picos de Europa National Park. This is a small airport with a very relaxed atmosphere. Arrivals and departures are fast and hassle-free. There are a few shops, a restaurant and three café/snack bars.
Low-cost airline EasyJet has flown direct to Asturias from London Stansted for a number of years. Frequency of flights has gone down in the last couple of years but they still remain the only economical way into this scenic area of Spain.
Flights from UK regional airports will almost certainly be indirect. It may be cheaper to fly to Madrid or Barcelona first. Flights to northern Spain also head for Bilbao, Santander, Valladolid and Santiago de Compostela. Note that Asturias airport is often advertised as Oviedo Airport.
ALSA airport buses run to Gijon and Oviedo approximately every hour. Buses to Aviles run approximately every 2 hours.
The only airline with direct flights is EasyJet.


text:
Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
April 20, 2005 05:16 PM Biotechnology
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Novel anti-cancer compounds called Enigmols suppress the growth of human cell lines representing cancers of the prostate, breast, colon, ovary, pancreas, brain and blood, and reduce tumors in three animal studies, new research shows.
In addition, Enigmols did not show side effects at effective doses, according to the research conducted at the Georgia Institute of Technology, Emory University and Wayne State University. The studies were funded by the National Cancer Institute.
"Many agents suppress cancer cells in a Petri dish and then not in the whole animal, or have unacceptably high toxicity for normal tissues," said Georgia Tech Professor of Biology Al Merrill. "Finding that Enigmols are effective in three animal models leads us to hope these may be a new approach to treat cancer." However, human trials must still be done to determine safety and efficacy in people, the researchers cautioned.
The findings will be presented by Georgia Tech postdoctoral researcher Qiong Peng on April 19 in a "late-breaking" poster at the American Association for Cancer Research 96th Annual Meeting in Anaheim, Calif. After considering comments from other scientists at the meeting, the researchers plan to submit the results to a scientific journal in coming weeks.
Enigmols are synthetic analogs of sphingolipids, a group of cell-signaling molecules that help cells decide whether to grow or die via a controlled process called apoptosis. Cancer cells are usually defective in these regulatory pathways, so researchers hypothesized that structurally modified sphingolipid analogs might be even better at making cancer cells behave more normally.
Merrill and his collaborators have been studying sphingolipids for more than a decade, having first shown that sphingolipids in food, such as low-fat dairy products and soybeans, suppress tumors in mouse models for colon cancer.
Encouraged by these findings, Emory University Professor of Chemistry Dennis Liotta and his colleagues at Emory prepared almost 100 sphingolipid-based analogs that lead to the discovery that the Enigmols were the most potent. The lead compounds were named "Enigmols" because sphingolipids were named after the sphinx for their enigmatic properties. Emory University holds the patent on compounds of this type.
In addition to being more potent than naturally occurring sphingolipids, the researchers have also found that Enigmols can be administered orally and appear in often-difficult-to reach organs such as the prostate. "This is what suggested to us that Enigmols should be tested against other cancer types," Merrill explained.
Subsequently, the researchers found that Enigmols suppress the growth of human prostate tumors implanted in mice, which is a commonly used model to test new anti-cancer drugs. They were also effective in two other mouse models for colon cancer.
"We do not know why Enigmols affect such a wide range of tumor cell types," Merrill said. "But it may be due to the involvement of sphingolipids in multiple cell-signaling pathways. This means a compound may affect several different targets, rather than just one."
In essence, Enigmols may act like a multi-drug combination therapy, the investigators speculate.
Enigmols are also being tested in combination with other cancer chemotherapeutic drugs using funds from EmTech Bio -- a life sciences technology business incubator operated by Georgia Tech and Emory. This research is coordinated with Slainte Bioceuticals, a start-up biotechnology company in metro Atlanta that is helping to bring this potential drug to market.
"Even if Enigmols are effective in humans, the greatest success is likely to come from the right combination of drugs that interact in a synergistic way," Merrill noted. So information from the EmTech Bio study may be particularly useful if Enigmols enter human clinical trials because the patients will have undergone, and will probably be undergoing, other treatments anyway, he added.
In addition to Merrill, Peng and Liotta, the research team is also comprised of: researcher Cameron Sullards of Georgia Tech and Emory researchers Dirck Dillehay, David Pallas, Selwyn Hurwitz and Anatoliy Bushnev; graduate students Holly Symolon and Sarah Pruett of Emory and Jeremy Allegood of Georgia Tech; post-doctoral fellow Steve Moody; and Georgia Tech research technicians Carrie Pack, Samuel Kelly and Elaine Wang. Additional collaborators at Wayne State University are Professors Eva Schmelz and Paul Roberts.
Source : Georgia Institute of Technology Research News
Synthetic molecules hold promise for new family of anti-cancer drugs
Anti-HIV drugs inhibit emerging virus linked to prostate cancer and chronic fatigue syndrome
Seaweed yields new compounds with pharmaceutical potential