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Precious Hearts Romances Presents: Los Bastardos ({{Literal translation|The Bastards}}) is a 2018 Philippine drama television series under Precious Hearts Romances loosely based on the Filipino pocket book novel Cardinal Bastards by Vanessa, starring Ronaldo Valdez, Jake Cuenca, Marco Gumabao, Albie Casiño, Joshua Colet, Joseph Marco, Diego Loyzaga and Gloria Diaz. The series premiered on ABS-CBN's Kapamilya Gold afternoon block and worldwide via The Filipino Channel from October 15, 2018, to September 27, 2019, replacing Precious Hearts Romances Presents: Araw Gabi and was replaced by Sandugo. The series was inspired by Fyodor Dostoevsky's The Brothers Karamazov.

Plot summary

Book One
Los Bastardos is based on the Cardinal Bastards series of Precious Hearts Romances Presents. The story follows the lives of five brothers struggling with one another for their rightful place in their father's heart. The root of their conflict stems from betrayals and secrets surrounding the individuals surrounding Don Roman Cardinal.

Don Roman is the illegitimate son of Don Ismael Cardinal, a wealthy sugar cane plantation owner of the fictitious region of Victorino in the rural outskirts of Manila, Philippines. He reunites with his father as an adult, eventually inherits his father's hacienda and starts a life with his small family when tragedy strikes and he loses his wife Soledad and son, Roman Jr.

Despite the tragedy, Don Roman pursues their dreams to expand and diversify the Hacienda and build a liquor distillery using ingredients from his sugar cane produce.

Throughout his unhappy and lonely life, Don Roman builds a successful empire and sires five sons from four different women. All his sons inherit his handsome physique, tenacity, superior physical strength and astuteness that serves them well in their respective fields, but two sons do not benefit from his inherent kindness because of the family environment they grow up in.

Roman Jr, later known as Isagani, is Don Roman's legitimate firstborn son with his wife Soledad, his true love. Don Roman and the town folks fear his young family perished in the mudslide. In fact, Soledad slips him into a passing produce truck. She pins her wedding ring on his shirt praying it would lead him to his father someday, but fails to get on the truck as it picks up speed to escape the oncoming mudslide. The child is raised by the farmers who discover the infant in their truck. Isagani Esperanza inherits his father's good qualities of kindness, compassion and bravery, as well as his father's physical strength, entrepreneurship and unique taste buds, essential for developing fine brandy. He formulates an arrack he calls Coco Brandy, when he was a student in Manila. Isagani buys a small coconut farm to set up his own distillery. He has the opportunity to realize his dreams when he is sought after by two major distilleries to partner with: the Cardinals and Silverios. Isagani chooses to partner up with the Cardinals because he admires Roman's kindness and fairness. A bond forms between Roman and Isagani though neither are aware of their kinship.

Joaquin is Alba Santillan's son. Alba is a spoiled heiress obsessed with Roman but fails to win his affection. She gets rid of Soledad and her infant by pushing them off the cliff. While grieving for Soledad, she seduces him one night and then tells him she is pregnant with his second son, Joaquin. In truth, she is already pregnant by her parents' gardener, Enrico. Roman loves the infant like his firstborn, and brings Alba and their son to live in his estate where he is raised as Roman's natural son. He never marries Alba but allows her to live as the mistress of the mansion for the sake of their son. Among the five brothers, Joaquin is the only son who grows up under his care. Joaquin has a strong and loving relationship with his father and inherits his father's fairness and kindness. Joaquin does not have the malevolent and selfish traits of his mother. He grows up to lead the management team of Cardinal Distillery, loved by all. Alba tries her best to poison Joaquin's mind against Isagani, but Joaquin's innate goodness prevails and he decides not to listen to his mother. He leaves for America to sort out his feelings, but tragedy struck when Joaquin died in a plane crash on ill-fated flight of LAKAN AIRLINES LAK271 or Flight 271 on his return. Alba's liaisons with the gardener is revealed at his memorial services. Despite the revelation Roman mourns Joaquin's passing and sends Alba away.

Matteo is Maddie Asuncion Silverio's son. Maddie is the emotionally abused socialite wife of Menandro Silverio and sole heiress of the Asuncion fortune. Drawn to the lonely Don Roman, their affair produces a son, Matteo, but she ends their relationship and raises the child as a Silverio, business rivals of the Cardinals; Aware of his wife's and Roman's betrayal, Menandro uses Matteo as his secret pawn for revenge against them. He raises the child to fear him, devoid of character and moral values, encourage his greed and teaches him to despise the Cardinals. Matteo yearns for his father's approval but never gets it as his father is abusive to his children and wife. Matteo grows up in a household filled with cruelty, hatred and fear.

Connor is Pilar's son, Roman's childhood friend who became a prostitute. Roman tries to save her from this life, and in their loneliness, they have a relationship.  When Alba learns that Pilar is pregnant with Connor, Alba confronts her, and successfully taunts Pilar into leaving Roman for a wealthy client in Japan. Disillusioned with her life, she takes her pain out on Connor and abuses him. She tries to sell him to a stranger for sex but is rescued by Fausto, a con artist, who raises Connor along the same path. The trauma of his mother's rejection changes Connor, his longing for a family is replaced with hatred towards his father who he believes abandoned him.

And finally there is Lucas, Sita's son.  Sita is an orphan raised in the Santillan household. She grows up as Alba's personal maid and witnesses Alba's duplicitous actions to ensnare Roman. In love with Roman herself, they have a brief affair and produce Lucas. When Alba discovers their relationship, she threatens to take Joaquin away. As a concession, Roman agrees not to acknowledge Lucas as his natural son but is firm that Lucas and his mother live in the estate where Lucas is raised as companion to his son Joaquin. As a result, Lucas grows up in the Cardinal household, treated like family but never knowing the man he serves is his own father. Roman loves Lucas and treats him with respect. He also teaches Joaquin to treat Lucas like a younger brother. Lucas inherits his father's leadership skills, and his mother's patience and gentle nature. He later learns about his paternity, and though conflicted at first, steps into his role as a Cardinal with strength and grace and serves his father well.

Ultimately, the five brothers' lives collide as they learn who their true father is.

Connor is the first son to discover his father's identity. Renowned in the criminal underworld as the best con artist, he makes it his personal mission to bring his father down, believing his mother's lies that Don Roman abandoned them. He ingratiates himself with Isagani and Lucas to get close to Don Roman. Isagani and Lucas expose his dubious activities prompting Connor to admit his true identity, but surprisingly, he gains the protection of Roman Cardinal, who is more than happy to reconcile with his son. Connor bides his time to win his father's trust. His ulterior motive is to gain access to all of the Cardinals' bank accounts, which he intends to transfer to his secret account. But his agenda changes after several attempts fail. He softens towards his father as he learns to trust and believe his father's unconditional love and acceptance of Connor, who always wanted a family to belong to.

Matteo, motivated at first to please his father Menandro, learns the truth that Roman is his real father. His keen astuteness allows him to swiftly figure out Menandro's real agenda. Furious over Menandro's treachery, he promptly strips him of his power and takes over the Silverio machinery, when he becomes the sole beneficiary of his mother's wealth. His hatred for Menandro equals his hatred for Don Roman, who he blames is the root of his miserable life. He plans to destroy him and take over the Cardinal empire.

Soon after Roman learns about his three sons, he discovers his lost first born son Roman Jr is Isagani Esperanza. The news is welcomed by Lucas but not by Matteo and Connor who realize Isagani is the legitimate son and another barrier to their evil plans.

Although they come from different worlds, the discovery that they are siblings affects each of the sons who carry the baggage of their fatherless youths.

Unlike Isagani and Lucas who embrace their kinship, Connor and Matteo blame their miserable lives on their father.

But as Roman attempts to reunite his sons, the greedy and vengeful individuals in his life make sure he fails: Menandro Silverio is determined to use Matteo to destroy him; and Roman's two former lovers - Alba and Pilar are equally set on seizing the Cardinal wealth.

Book Two
While Don Roman tries to get his four sons to reconcile, a wealthy young man in Los Angeles is preparing for a trip to the Philippines. Lorenzo Cuevas wants to destroy Roman Cardinal too. He is Don Roman's second son with Soledad.

Flashback to a few years ago, his adoptive father reveals to him on his deathbed the truth that his real father is Don Roman Cardinal, the powerful ''Hacendero'' (landlord) of the Cardinal Plantation and Cardinal Distillery.
Don Pablo Cuevas tells Lorenzo of coming across Soledad a few days after typhoons and mudslides devastate the southern region of the Philippines, wandering the countryside, distraught, disheveled, with no memory of who she is or where she comes from. A few weeks pregnant, she suffers bruises and serious injuries sustained from a violent assault. He cares for her and search for her family but initially, no information surfaces.

Suffering from memory loss as a result of her traumatic escape, unaware of the full facts about Alba's attempts on her life, Don Pablo Cuevas assumes she is running away from an abusive relationship. Upon investigating further, he traces her former husband to the powerful hacendero (or Hacienda owner, plantation owner) Don Roman Cardinal, who by now is living with a new family (Alba and a their infant son). Believing she is in danger and seeking to protect her, he takes the pregnant Soledad away from the Philippines and they move to California to start a new life. He renames her Consuelo and gives her and Lorenzo his surname. Consuelo recovers from her physical injuries, but her memory of her life with Don Roman and her first born son remains buried. Lorenzo believes Don Pablo Cuevas' story about Don Roman's abusive treatment towards his mother and seeks to avenge her.

He conducts an investigation of the Cardinals and learns about his four other brothers. He arrives in the Philippines and arranges to meet his father and his brothers under the pretext of a business partnership with his own multinational hotel and resort corporation. He ingratiates himself with them through his previous business deals with Joaquin while the latter was in America.

Meanwhile, in Los Angeles, Soledad decides to return to the Philippines to join her son. As she arrives in Victorino, the scenic drive down the countryside gives her a sense that it was a part of her past. Unknown to all including herself, Consuelo Cuevas is the true matriarch of the Cardinals. Soledad Cardinal returns to Victorino.

Inside the Silverios' crumbling empire, Matteo decides to use his sister Dulce to get Lorenzo to partner with them. Lorenzo, on the other hand, uses Dulce to undermine Isagani, to make it easier for him to destroy his siblings and ultimately Roman.

As Consuelo gets acquainted with Victorino and San Jovita, she is inexplicably surprised by its familiarity and happy with the peacefulness and beauty of its surroundings. She tells Lorenzo that she sees herself retiring there. She meets new friends and discovers a Nipa hut which she finds vaguely familiar. The caretaker tells her it is uninhabited but maintained by Don Roman Cardinal, a name that doesn't mean anything to her yet.

In the meantime, Connor begins to self destruct. Drowning in his anger towards his father and jealous of his brothers' better stations in life, he drives himself into a downward spiral. In a drunken stupor, he attempts to rape Isay who is on her way home, but his partner Lupita intercepts him, renders him unconscious, and forcibly removes him from the site. Isagani finds her on the roadside and as he tries to get help, Matteo drives by and side swipes him off the ravine. This is how Consuelo Cuevas, on her way home from a day of sightseeing, finds him. Alarmed at his condition, she instructs her driver to pick him up and brings him to the Cuevas resort to be treated.

News of the unconscious man rescued by Consuelo reach the Esperanzas who rush to the Ashton Resort, overjoyed to see Isagani. Consuelo remembers Irma from the Carinderia (Filipino term for a roadside cafeteria) where she enjoyed a delicious Ginata-án a visit stirring a pleasant yet still unknown memories.

Alba is busy planning to get rid of Soledad again. She kills Enrico whose extortion attempts were distracting her, and joins forces with Menandro and Pilar, who share the same goal to destroy the Cardinals and steal their wealth.

Meanwhile, Consuelo's and the Cardinals' worlds become smaller as their orbits grow closer. She is equally puzzled over her overwhelming emotions when Isagani shows her a photograph of Don Roman.

Certain that Consuelo would come face to face with Don Roman soon, Lorenzo steps up his plans for revenge. He rejects the business merger with the Cardinals and join forces with the Silverios.

Meanwhile, Consuelo seeks the help of specialists in Manila, certain her dreams are related to her past.

Alba's mental illness declines further, plagued by nightmares of Enrico and other heinous crimes she committed. Isagani witnesses her hallucinating a conversation with Joaquin, as she confesses of Enrico's murder.

Meanwhile, Roman is trying to piece things together, determined to get answers as to why Lorenzo is bent on keeping Consuelo away from the Cardinalsas. When he catches up to the woman interested in Soledad's Bahay Kubo, he is shocked when he recognizes Soledad! He tries to catch up with her at the Resort, where he is first denied entry. His imposing personality intimidates the security and staff as he goes in unchallenged. Searching every room in the resort, he finds her photograph with Lorenzo, and recognizes Soledad, his long lost wife. As Lorenzo and Isagani follow after him, Lorenzo reveals the truth that he is Soledad's second son, and that his adoptive father told him that his real father is Don Roman Cardinal, the abusive husband of Soledad Cardinal, who thought he killed her and then quickly took another woman and son to live with him

While Don Roman tells him the real truth, he receives a call from Alba who has Soledad as hostage. Alba wants Roman to find her so she can kill him. Soledad tries to escape from Alba when she recognizes Alba as the woman who tried to kill her and her infant son decades back. She knocks down Alba with a large dead branch and renders her unconscious.

Meanwhile, Roman and his two sons reach Alba's home and find Soledad. She immediately recognizes Don Roman and they are reunited. Alba awakens from her unconsciousness but loses her balance, falls off the cliff and is impaled on a dead tree trunk.

Reunited at last, Soledad and Lorenzo move into the mansion, and the brothers make an effort to adapt to the new family dynamics. Soledad accepts Roman's illegitimate sons and plans to get them together as a family. But their first family dinner is a disaster when Lorenzo and Matteo comes to blows after Lorenzo terminates their business partnership.

Meanwhile, Gigi who is still reeling from Matteo's rejection, joins forces with Menandro to bring down the Cardinals and ultimately take revenge on Matteo. Gigi runs the illegal gambling den and leads the hardcore criminals and the underworld.

Soon after the family dinner, Lorenzo hosts an Ashton Resorts' grand opening with members of the business and social community attending, everyone except Matteo. Unfazed, Matteo hires an assassin to bomb the resort to create chaos and mayhem. His instructions were to plant the bomb outside the building, ensuring no one gets hurt.

Menandro takes this opportunity to derail Matteo. He overrides Matteo's instructions and pays the bomber-assassin to shed blood, maim the victims and then point the blame on Matteo.

That evening, Matteo arrives at the resort, gleefully anticipating to witness the commotion caused by the bomb. He catches the bomber on his way out and realizes the bomber planted the weapon inside.  Matteo rushes in and tries to warn people away but it is too late for many guests, especially Sita.

While everyone enjoys the festivities, Sita notices a man leaving hastily and as she tries to get closer to him, notices a glowing contraption he left in a flower bush. At the same time she sees Matteo from the upstairs window waving her away and realizes the presence of a bomb near her. Though she tries to run away to warn everyone, it detonates, hitting her with shrapnel and knocks her down.

Sita dies soon after she is rushed to the hospital, but not before she is able to speak to Roman and Soledad, entrusting Lucas to them. She also gets to say goodbye to Lucas, who is devastated. Her death changes Lucas.

Although the police are gathering evidences surrounding the bombing, Lorenzo and Connor suspect Matteo is involved so they investigate on their own. Lucas also suspects Matteo since he saw him at the resort. To avenge his mother's death, Lucas joins the criminal underworld of Gigi where he learns how to fight. Lucas successfully captures Matteo, tortures him in an abandoned mine and plants a bomb and detonating device to kill him. As his siblings find him, Matteo accidentally trips the detonator and a large explosion seals the cave entrance. He escapes and leaves his siblings trapped inside. They are rescued by Connor.

Fully recovered, it's business as usual for Lorenzo who takes over the Silverio Distillery angering Menandro and kicks him out.

Lucas, meanwhile, tormented over his mother's death, succumbs to Gigi and her dark criminal world. Lucas turns his back against his family.

Elsewhere, Matteo is in danger as the Silverio mansion is set on fire by Menandro and Pilar. Don Roman orders Lorenzo and Connor to rescue Matteo.

Don Roman and Soledad, decide to take Matteo into their home. He pretends to get into their good graces but continues his sinister plans to destroy the Cardinals.

Meanwhile, Isagani asks Connor to help him infiltrate Gigi's gambling den where Lucas is. Isagani enters the gambling den and confronts Lucas, but gets a brutal beating by Lucas before escaping the premises. Don Roman decides to call the authorities with Matteo's assistance and Gigi is captured.

While attempting to rescue Lucas, Don Roman is shot, damaging his liver. It turns out Lucas is the only match for Roman's liver transplant.

Gigi is shot and killed by a mysterious assassin in the presence of Lupita and Fausto. Lucas, Fausto and Lupita flee the scene. Menandro and Pilar discuss the shooting but are unaware who did it. The mysterious shooter turns out to be Catalina Silverio's henchmen. Catalina is Menandro's lost sister, also seeking revenge against Don Roman.

Matteo attempts to kill Soledad but is foiled by his siblings. Matteo escapes to hide in an old Silverio vacation home to regroup and recuperate from his injuries.

In the midst of all the conflict, Isagani proposes to Isay who accepts.

Lucas vows to change and rejoin the family and also donates part of his liver to save Roman.

Book Three
A new enemy emerges: Doña Catalina Silverio Pacheco. Her father was one of the bandits who ambushed Roman and Soledad early on, was sent to prison for it and later killed in a prison brawl. Her father's death leaves her and older brother Menando Silverio orphans. Menandro sells her to Eduardo Pacheco, a wealthy criminal boss, who marries and abuses Catalina.  She loses her child, but poisons him and inherits all his wealth upon his demise. She blames Soledad and Roman Cardinal for her misery.

When Menandro fails to destroy the Cardinals, Catalina takes over, arriving with her army of female assassins.

Although Lorenzo and Lucas want Matteo to pay for his crimes, Don Roman wants to give him a chance to return into their fold. Hence, the brothers continue to search for Matteo with mixed feelings.

Meanwhile, we learn that Dulce is the infant taken from Catalina by her husband and given to Menandro to kill.  Unable to kill his infant niece, Menandro legally adopts her as a Silverio.

Catalina locates and ingratiates herself to Dulce, gains her trust, and uses her as a pawn in her revenge plan. She easily manipulates Dulce to turn against the Cardinals. Jealous of Isay and Isagani's happiness and upcoming engagement, Catalina pushes Dulce to separate the young lovers. Dulce urges Matteo to gate crash Isagani and Isay's 'Pamanhikan', an engagement dinner when the bridegroom's parents ask for her hand.

At the Engagement dinner, Matteo arrives and announces that Connor was Isay's rape assailant.  Furious that Isay was placed in peril, Nante believes that Isagani covered it up to protect his brother. Nante calls off the engagement, instructing Isay to cut ties with the Cardinals, and files attempted rape charges against Connor and obstruction of justice against Isagani. The relationship between Isay's father and the Cardinals and Esperanzas quickly deteriorates. The wedding plans are canceled.

Don Roman banishes Matteo. As a result, the brothers gather all their evidence and file multiple charges against Matteo who is arrested and incarcerated.

While the Fiscal office finds Nante's charges against the Cardinal brothers without merit, Nante plans to take Isay to Catbalogan. Meanwhile, Catalina befriends Soledad and Roman and manipulates Dulce, now estranged from the Cardinals. Her toxic influence quickly transforms Dulce from a good doctor into an enemy of the Cardinals.

Unaware of Dulce's duplicity, Isay turns to her trusted friend, who urges her to choose her father. To Dulce's frustration, Isagani refuses to give up on their love, convincing Isay to elope, have a church wedding and then face Nante's ire together. Isay confides in Dulce, who wastes no time warning Nante, foiling their marriage plans once again.

Back in jail, Matteo enacts a fake attempt on his life following a plan hatched by Catalina and Dulce, to get him confined into a mental institution where Catalina is a major benefactress and can control the environment.

Elsewhere at the resort, Diane gets wasted after being stood up on her blind date. Three men try to take advantage of her inebriation, but Lorenzo rescues her from their aggressive advances and has security kick them off the premises. As he tries to knock some sense into Diane, they become intimate and end up sleeping together. This affects their working relationship soon after as both are confused and awkward with each other. Lorenzo tries to admit his real feelings but is confused about it.

Meantime, Nante has a change of heart when an attempt is made on Isay's life by Catalina's assassin. He witnesses the Cardinals risk their own lives to rescue his daughter. Nante gives his blessings for their wedding.

Meanwhile, Don Roman is shocked to see Matteo's deteriorating mental state and tries to have him transferred. Unknown to everyone, Matteo is being slowly drugged with powerful psychotic drugs by medical staff under Catalina's orders.

By this time, Catalina's unusual interest in Soledad and Roman arouse their sons' suspicions. The Cardinals uncover the connection between Menandro and Catalina, and confirm she is the shadowy Señora referred to by criminals. Lucas also overhears Menandro boasting that the bomb exploding inside the resort that killed his mother, was his idea - "Matteo simply wanted to scare, but I wanted to maim and kill." Isagani also discovers that Catalina has been visiting Matteo in the mental facility on several occasions. When Don Roman tries to have him transferred, Dulce refuses and instead demands the Cardinals to stay away from Matteo, threatening a restraining order.

Dulce's transformation from a kind, and compassionate doctor into a jealous and unreasonably scorned woman, is complete. She tries to poison Isay and almost kills Isagani. Distraught, she calls Catalina who reveals that she is her mother. From this point, Dulce blindly obeys her mother.

Earlier at Catalina's island, Señora advises Lupita and Fausto that they cannot leave until they complete their next assignment. Lupita wants out but Catalina holds Fausto hostage. Catalina recognizes Lupita's superior skills and intends to gain her loyalties so she can serve as her eyes and ears in Menandro's gambling world. Lupita plays along.

Meanwhile, the Cardinal brothers obtain evidence of Catalina's shadowy world and her using Matteo's mental illness to harm the Cardinals. Connor also discovers Lupita in Menandro's illegal gambling den. She helps him escape and tries to convince her to escape with him but she won't abandon Fausto. The Cardinals hatch a plan to capture Catalina and Menandro, and rescue Lupita and Fausto.

Knowing her cover is blown after an acrimonious heart to heart between Soledad and Catalina turns ugly,  lines are drawn. Catalina arranges for Matteo to leave the facility and calls Dulce, Matteo and Menandro to her secret base in Santa Jovita where she reads them the riot act on the final destruction the Cardinals. She is unaware that Soledad has her sons following Menandro, Dulce and Matteo, and the four brothers witness the meeting.

Dulce tries one last time to win Isagani back and fails. As planned, the Cardinals follow her as she unsuspectingly leads them to the Silverios' new gambling den. Carolina comforts the distraught and near-hysterical Dulce. Isay is saddened over Dulce's deception. The Cardinals have the gambling den raided and closed, effectively shutting off Catalina's main source of cash liquidity.  The Silverios go into hiding.

While a nationwide search is conducted by the police, the Cardinal wedding ceremony goes without incident, although the brothers intercept a sniper assassin hired by Menandro to massacre the bride and groom and as many guests as possible. The couple learn about the attempt after they return from their honeymoon. Connor was alerted by Lupita who is determined to protect Connor and the Cardinals.

The Cardinals continue to pursue the Silverios, gathering as much evidence to bring them to court. They learn that Matteo is released from the mental institution but they do not know where he is hiding. Fact is, he is brought to Catalina's secure island fortress, where she incarcerates Menandro for his failure to stop the Cardinal wedding. Matteo is Catalina's chief weapon to use against Roman, who is not giving up on his wayward son. Dulce, on the other hand, has a revenge plan of her own. Furious over her mother's failure to stop the wedding, she secretly leaves the island on several trips to follow Isagani to his new home with Isay.

Isagani built Isay a beautiful matrimonial bungalow and the newlyweds are enjoying their first weeks as man and wife.  Unknown to them, Dulce watches and plans her next move, even entering their home while Isay tends to her household chores.

In the meantime, Lorenzo realizes he is in love with Dianne but her familiarity with Connor makes him jealous. Things come to a head when he comes across Connor and Dianne in an embrace. Though it was a brotherly hug, Lorenzo's jealousy erupts into a fight with Connor. Furious, Dianne confronts him where he finally admits he is in love with her. Diane refuses to believe Lorenzo's sincere feelings for her.

Finale

Another tragedy hits the Cardinals when Catalina ambush and assassinate Bert and Irma Esperanza.

The ambush occurs on route to Irma's surprise birthday party. Lorenzo, following as escort behind the van, is overpowered by Catalina's men. During the altercation, Catalina arrives and shoots the couple in cold blood. Isagani's parents die in each other's arms, and that is how Isagani finds them.

The deaths of his adoptive parents affect Isagani who embarks on a murderous rampage for justice.  The Cardinals once again cast their safety net and fight to get Isagani back into their fold.

The Cardinals learn that Menandro and Pilar are working with Catalina. To trap Catalina, Isagani pretends to forsake Isay and his family in a ploy to penetrate Catalina's hideout. The plan works and Pilar recruits him for Catalina.

Catalina tests Isagani's loyalty, ordering him to kill Isay, and then instructs Dulce to accompany him to make sure she is dead. Isagani poisons his wife and she succumbs to the toxin, but Connor brings the antidote in time to revive her.  The plan works as Catalina brings Isagani into her force as her assassin.

Their plan unravels when Matteo discovers Isagani with Isay and his brothers.  He finds Menandro hiding in Isagani's hideout, traps and kills Menandro in the burning house, and returns to tell Catalina.

Meanwhile, out to settle her score against Catalina, Nina discovers that Lupita is working against Catalina, captures her and brings her back to the Island to claim back her position as Catalina's right hand. Both Lupita and Fausto are tortured.  They are saved by the arrival of the Cardinal brothers and the authorities.  Catalina escapes with Nina and Mateo but blows up the island.  Connor saves Lupita by switching the bomb jacket. The boat explodes and Connor is missing, feared dead.

While the Cardinals and the authorities search the surrounding areas for Connor, Lupita and Fausto are rushed to the hospital. Dulce is among Catalina's army captured during the raid. With plans to escape, she shoots herself so they bring her to the hospital instead of prison.

Meanwhile, her army diminishing into a handful, Catalina hides in her childhood home. Matteo is her only weapon remaining as she fuels his anger with a psychotic drug.

As the Cardinals escalate their raids on Catalina's criminal network, Catalina's key henchmen are captured, including the mayor who provides her safe passage, her lawyer and Nina. They cooperate with authorities to catch Catalina.

Meanwhile, Dulce escapes from the hospital but is captured by Pilar. Matteo obtains crucial information on the Cardinals' vulnerability: the Cardinal women. Catalina orders her remaining army to kidnap the Cardinal women, offering the last of her gold bars as reward.

The Cardinals learn the source of Catalina's hatred towards them: she blames Roman & Soledad for the death of her father, a bandit they had fought off and sent to jail long ago. The Cardinal successfully rescue their girlfriends, but are blindsided by the home invasion of the Cardinal Estate by Matteo, Dulce and Catalina. Roman & Soledad are taken hostage. As the Cardinal brothers rush to their parents, their girlfriends rescue Connor.

The brothers are captured and reunited with Roman and Soledad who are strapped with a bomb. An argument ensues between Catalina and the Cardinals, Matteo is surprised that his brothers and his father continue to fight for his right as a family member.  Roman suffers a heart episode which requires his medication, asking Matteo to retrieve it, which he does.  This enrages Dulce, and as the siblings get into a violent argument, the Cardinal brothers, free their parents and hide inside the large mansion.

Catalina breaks up the fight between Dulce and Matteo. She recaptures the Cardinal brothers, and orders Matteo to kill them. He refuses, further infuriating Catalina who decides to take matters into her hands and detonates the bombs her henchmen planted throughout the mansion.  Fortunately, Connor and the Cardinal women successfully detonate the bombs a few minutes earlier.  Horrified that her mother is bent on killing them all, Dulce tries to escape, but is overpowered by Lupita and the Cardinal women.

Matteo, battling the demons exacerbated by the drugs Catalina feeds him with, begins to doubt his hatred towards the Cardinals.  As he hesitates finishing off his brothers, Roman comes forward to embrace his wayward son. Mad out of her mind, Catalina fires at Roman but Matteo takes the bullet and pushes Catalina off the stair rails.

Despondent, Matteo goes to the mansion's balcony and attempts suicide as he recalls how he has lost everything, including his mother. Roman and his brothers plead with him to not kill himself. Each ask him to forgive them for their misjudgments and lack of compassion, and the sins they committed against him. Remembering Sita's words to him about forgiveness, as she tended to him on the road, Matteo forgives his brothers.

He is sent to a mental institution for rehabilitation.  Dulce is sentenced to life imprisonment, and Catalina survives the fall and committed to the psych ward in a mental institution.  She lives the rest of her life in a straight jacket, losing her mind completely over imagined rats surrounding her bed.

With the Silverios finally defeated, the Cardinals finally live in peace, marrying their loved ones and have children. At Lucas' and Coralyn's wedding, Isagani learns that Isay is pregnant again, while Lorenzo and Dianne have three children. The last scene shows the entire family eating lunch al fresco celebrating another milestone: Matteo is finally released from the mental hospital fully rehabilitated. He begins rebuilding his relationship with his brothers, their wives, his father and Soledad.

Cast and characters

Main

Don Roman Cardinal, Sr.
 Played by: Ronaldo Valdez and Geoff Eigenmann (young)
-The Cardinal patriarch, and the father of Cardinal boys, who is an illegitimate child of Don Ismael Cardinal. He married Soledad, but because he believed that his wife and son are dead after the mudslide accident, he had an affair to three another women that gave him another child aside from Roman, Jr.

Doña Consuelo Cuevas / Doña Soledad de Jesus-Cardinal
 Played by: Gloria Diaz and Cristine Reyes (young)
-The Cardinal matriarch, the mother of Roman, Jr. (Isagani) and Lorenzo and also Don Roman's first love. After the mudslide she lost her memory and renamed as Consuelo. But unknown to Roman, she is pregnant to their second son, Lorenzo when accident happens. When her memory comes back, she acts as a kind and loving stepmother to another sons of Roman.

Isagani "Gani" Esperanza / Roman De Jesus-Cardinal, Jr.
 Played by Jake Cuenca
-Roman's and Soledad's first child, He was adopted by Bert and Irma and renamed as Isagani. He is kind, compassionate, brave and he also has his father's physical strength, entrepreneurship skills and unique taste buds which is essential for developing fine brandy. He is Lorenzo's "full" brother. He is the fourth Cardinal who discover his real identity.

Lorenzo "Enzo" Cuevas / Lorenzo De Jesus-Cardinal
 Played by: Joseph Marco
-The second son of Soledad to Roman who is a successful businessman. He wants to revenge to Don Roman at first because he believes that he and her mother were abandoned by him until he realize that those statements are not true. He is Isagani's "full" brother.

Matteo Asuncion-Silverio / Matteo Asuncion-Cardinal
 Played by: Marco Gumabao
-The son of Don Roman to Madeleine, Menandro raised him as his own, but unknown to Matteo, he is only using by Menandro to revenge on Cardinals especially to Roman. He is the second Cardinal who discover his real identity.

Connor Perez-Davide / Connor Perez-Cardinal
 Played by: Joshua Colet
-Roman's son to his childhood friend name Pilar who is a prostitute. He was maltreated by her mother at his young age and sold him to a foreigner. Fausto rescued him and make Connor a con artist like him. He is the first one to discover that he is a true-blooded Cardinal.

Lucas Aguilar-Cardinal
 Played by: Albie Casiño
-Roman's son to Alba's personal maid named Sita. He inherit his father's leadership skills and his mother's patience and gentle nature. His mother's death changed him to a vengeful person that leads to his decision to join on criminal underworld of Gigi to give justice on her mother's death. He is the third Cardinal who discover his real identity.

Joaquin Santillian-Matias / Joaquin Santillian-Cardinal
 Played by: Diego Loyzaga
- He is Alba's son who grow with Don Roman. He inherit Don Roman's fairness and kindness but not his mother's malevolent and selfish traits. He grows up to lead the management team of Cardinal Distillery. But unknown to him, he is not a true blooded Cardinal instead he is the son of Alba from her parent's gardener named Enrico. He died in a plane crash.

The Cardinal Ladies

Diane Liwanag-Cardinal
 Played by: Ritz Azul
-She works as Executive Secretary of Joaquin, Lucas & Don Roman at Cardinal Distillery. She is also Connor's friend and Lorenzo's love interest.

Francesca Elizabeth "Isay" Navarro-Cardinal
 Played by: Maxine Medina and Yesha Camile (young)
-Nante and Belen's daughter and also Isagani's love interest and wife.

Coralyn Montesevilla-Cardinal
 Played by: Mary Joy Apostol
-Lucas' childhood friend and love interest.

Lupita Bermudez-Cardinal
 Played by: Mica Javier
-She has good combat skills and works for Senyora. Unknown to them, she is spying them to give information to the Cardinals. She is Connor's love interest.

The Silverios

Menandro "Manding" Silverio
 Played by: Lito Pimentel and Angelo Ilagan (young)
-The Silverio patriarch and owner of Silverio Distillery, he adopt Matteo to use him as pawn to avenge to the Cardinals. He sold his sister Catalina to a rich  criminal named Eduardo in exchange of money. She killed her own wife Madeleine and Sita. He died after Matteo left him in a burning house.

Madeleine "Maddie" Asuncion-Silverio
 Played by: Joyce Ann Burton and Cindy Miranda (young)
-Matteo's mother. She is an abused socialite wife of Menandro. She is the sole heiress of Asuncion fortune. She was killed by Menandro in front of Matteo.

Dulce Rodriguez / Dulce Silverio
 Played by: Kylie Verzosa
-Catalina's daughter from another man. Eduardo asked Menandro to kill her but he adopted her instead. She liked Isagani very much. She's a kind and compassionate doctor at first but she became a jealous and unreasonably scorned woman. She end up in jail and sentenced lifetime imprisonment.

Catalina "Senyora" Silverio-Pacheco / Catalina Rodriguez
 Played by: Jean Saburit and Claire Ruiz (young)
-Dulce's mother and Menandro's sister. On her young age, Menandro sold him to Eduardo in exchange of money. She create her own organization with female assassins, She despises Roman because she believed that he killed their father and his long-lost brother Menandro for his bad experience after he sold her to Eduardo.

Supporting cast

Pilar Perez
 Played by: Pinky Amador and Danita Paner (young)
-Connor's mother and also Roman's childhood friend who is a prostitute. She maltreated Connor and sold him to a foreigner. Like Alba, she has ambition to get the wealth of the Cardinals. She ended up in jail.

Fausto Davide
 Played by: Jeffrey Santos and Alex Castro (young)
-He saved Connor after his mother sold him to a foreigner, he trained Connor to become a con artist like him. He became a father to Connor until the latter discovered his true identity.

Marta Evangelista
 Played by: Perla Bautista
-a household worker of the Cardinal residence. She act as grandmother to Connor that makes the latter to trust the Cardinals.

Enrico Matias
 Played by: Jeric Raval and Jerome Ponce (young)
-A gardener of Santillian family, He is also the biological father of Joaquin. He extort money from Alba in exchange of his silence about Joaquin's real identity. He was killed by Alba.

Teresita "Sita" Aguilar
Played by: Ana Abad Santos and Mara Lopez (young)
-Lucas' mother, and Alba's personal maid. On her younger age, she express her feelings to Roman that produce Lucas. She also knows the fact that Joaquin is not a true-blooded Cardinal. Her death in resort bombing organized by Menandro changed Lucas.

Gigi Octavio
 Played by: Jane Oineza
-the owner of gambling den and the leader of criminal underworld where Lucas joined. She likes Matteo very much. She was killed by Catalina's assassin.

Alba Santillan
 Played by: Isabel Rivas and Roxanne Barcelo (young)
-Joaquin's mother. She uses Joaquin to get the wealth of the Cardinals. When Soledad was lost, she stayed at the mansion as mistress for Joaquin's sake but Roman didn't marry her. She died after falling in a cliff.

Robert "Bert" Esperanza
 Played by: Efren Reyes and Alex Medina (young)
-The foster father of Isagani. He and his wife Irma died in ambush.

Irma Esperanza
 Played by: Rosanna Roces and Katya Santos (young)
-the foster mother of Isagani. She and his husband died in an ambush.

Reynante "Nante" Navarro
 Played by: Jun Nayra
-Isay's father. He is against Isagani and Isay marriage at first because Connor sexually assaulted her daughter. But when Isay was kidnapped by Catalina's men and he saw the willingness of Cardinal brothers to risk their lives for his daughter, he gave his blessing to Isagani marry his daughter.

Guests

Jamil Muñoz
 Played by: Luis Hontiveros
-Lucas' person under Gigi's organization.

Eduardo Pacheco
 Played by: Toby Alejar
-a criminal rich man who buy Catalina from Menandro.

Belen Navarro
 Played by: Isay Alvarez
-Isay's mother.

Nina
Played by: Sarah Jane Abad
-Senyora's right hand on her organization. She despises Lupita because she consider her as a threat to her status in the organization.

 MM Gigante as France
 Alvin Anson as Mr. Chan
 Teroy Guzman as Mr. Cuevas
 Alex Calleja as Danilo
 Mike Lloren as Menandro and Catalina's father
 Manuel Chua as Ernesto

Special participation

Don Ismael Cardinal
 Played by: Dante Rivero
- The previous Cardinal patriarch who owns a wealthy sugar cane plantation owner of the fictitious region of Victorino. He has illegitimate son named Roman. He only met him when he was an adult.

Broadcast
Los Bastardos premiered on October 15, 2018.

In 2020 it is being replayed on Jeepney TV.

Reception

See also
List of programs broadcast by ABS-CBN
List of ABS-CBN drama series
List of programs broadcast by Jeepney TV

References

External links

ABS-CBN drama series
Philippine telenovelas
Philippine romance television series
Philippine crime television series
Philippine action television series
Philippine thriller television series
Philippine mystery television series
Television shows based on books
2018 Philippine television series debuts
2019 Philippine television series endings
Filipino-language television shows
Television shows set in the Philippines
Television series set in 1984
Television series set in 1986
Television series set in 1988
Television series set in 1989
Television series set in the 1980s
Television series set in the 1990s
Television series set in 1990
Television series set in 1991
Television series set in 1993
Television series set in 1996

redpajama_set_name: RedPajamaWikipedia


text:
Protesters Clash Over Lake Eola Confederate Statue
Monday, May 15, 2017 by Catherine Welch (WMFE)
Kim Portious, right, calls for the statue's removal surrounded by those who want it to stay./Photo: Catherine Welch, WMFE
Orlando Mayor Buddy Dyer says the confederate statue at Lake Eola should be moved to Greenwood Cemetery. The Orlando Sentinel reports Dyer made the suggestion after resident David Porter called for the statue's removal.
Outside City Hall protesters clashed, many of them wanting the statue to remain and waiving confederate flags.
"We've got to stand up for it, because it is part of our history, it's our heritage and it's what our ancestors did, said Dannie Nelson.
But Kim Portious disagrees, saying it marks an ugly chapter in American history.
"We are in 2017 and we need to take a better stand and say 'we're better than this.'" We need to take it down and put something beautiful that represents all of us," said Portious.
The statue was commissioned by the United Daughters of the Confederacy and has stood at Lake Eola for 100 years.
Porter said the statue is not valid without historical context, and suggested placing it in a history museum where it can be explained.
Tags: confederate, Lake Eola
Posted in Central Florida News
About Catherine Welch
Catherine Welch
Orlando To Cap Marijuana Dispensaries, Treat Them Like CVS
SpaceX Falcon 9 Lofts Its Heaviest Satellite Into Orbit

redpajama_set_name: RedPajamaCommonCrawl


As a home-based business entrepreneur, you are probably keenly aware of why avoiding "home business burn out" is so important. Even if you have only been working in this area for a short time, you can probably already see how easily that fatigue may set in. Many individuals learn from their life experience to deal with the burnout factor by pacing themselves, eating better, relaxing whenever practical, exercising on a regular basis while getting sufficient sleep (minimum 6 hours). But while these steps are of paramount importance at every stage of life, they are even more essential when you launch your business since the mental and physical strains are so acute during this period. When you are merely an employee, you may have been accustomed to a certain job and therefore left other details to others. But a work-from-home business will generally demand a wider spectrum of responsibilities than that. Much like a movie actor who decides to direct the film as well, the home-based business entrepreneur must rise to the occasion, and often with the life savings on the line and virtually no inherent benefits.
To help prevent the stress and pressure that may ultimately lead to burnout, there are some things that may help. The most important of them may be your overall attitude. Try not to make a mountain out of a molehill. As you set out on your new path, mistakes are bound to occur. Be ready for them and even embrace them because they are simply a part of the learning and growing process. Errors usually mean you are learning something new, regardless of what you learned about mistakes in school. Don't make a bigger issue out of errors than you have to. The same goes for incidents that seem to be a result of "bad luck". In these trying situations it is all too easy to think that you are being victimized but do not fall into the trap of making these incidents worse than they are because they also happen to every home business proprietor at some point or another along the way.
It is essential to eat healthy food whenever you can. If you attempt to subsist on pizza and fast food you can be assured of reaching burnout at some point. Your body and mind need quality nutrition to combat the massive stress of running your own business venture. Antioxidants are key in this regard. Vitamin C and E are perhaps most helpful, but don't forget the fresh fruits and vegetables. Keep your immune system in shape because you probably cannot afford to be away from your business for long at this early stage. You also will need plenty of fluids. Dehydration is common in these scenarios. Also make certain to make time for R & R. Anything that diverts your mind for a just few hours may be of assistance. Simply seeing a movie may help alleviate the stress somewhat. But you also will require to a regular vacation as well so do not neglect to plan for this. Onr thing that can definately help you fell more relaxed is using heavy breathing.
Just breathe in slowly for a count of seven and then breathe out for a count of eleven.
About the Author: Aaron Wilmont is a home business writer.


text:
Frederick M. Ausubel (né le ) est un biologiste moléculaire américain et professeur de génétique à l'Harvard Medical School de Boston et est chercheur émérite Karl Winnacker au département de biologie moléculaire du Massachusetts General Hospital dans le Massachusetts.

Éducation
Il obtient son diplôme de premier cycle en 1966 à l'Université de l'Illinois à Urbana-Champaign, puis son doctorat en biologie en 1972 du Massachusetts Institute of Technology, Cambridge, dans le Massachusetts.

Recherches
Les travaux scientifiques d'Ausubel portent sur les interactions hôte-microbe. Dans les années 1970 et 1980, son laboratoire travaille sur la base moléculaire de la fixation symbiotique de l'azote, processus par lequel les légumineuses, de concert avec un symbiote bactérien, convertissent l'azote atmosphérique en ammoniac. L'un de ses post-doctorants à cette époque était Sharon R. Long. Au cours des 20 dernières années, le laboratoire d'Ausubel a travaillé sur le développement de systèmes de pathogenèse dits multi-hôtes qui impliquent l'infection d'hôtes, y compris le nématode bien étudié Caenorhabditis elegans et la plante de référence Arabidopsis thaliana, avec une variété de pathogènes bactériens et fongiques. Ses recherches ont permis d'élucider les voies de signalisation immunitaire innées chez ces deux hôtes modèles et de déterminer quels aspects de la réponse immunitaire innée sont conservés et s'ils sont issus d'un processus d'évolution divergente ou convergente. Son laboratoire utilise actuellement le modèle de pathogenèse de C. elegans pour étudier l'immunité épithéliale intestinale et la façon dont les hôtes distinguent les agents pathogènes des micro-organismes commensaux bénéfiques. Les travaux connexes dans son laboratoire portent sur l'identification et la caractérisation de composés de faible poids moléculaire qui activent spécifiquement les voies de signalisation immunitaire de C. elegans.

En 2013, Ausubel avait publié 215 articles scientifiques. En plus de siéger à divers comités de rédaction, il est l'éditeur fondateur de Current Protocols in Molecular Biology. Il est élu membre de l'Académie nationale des sciences en 1994, de la Société américaine de microbiologie en 2002 et de l'Académie américaine des arts et des sciences en 2003.

Prix
Il reçoit la médaille Thomas Hunt Morgan 2014 pour l'ensemble de ses réalisations dans le domaine de la génétique.

Références

Liens externes

 http://ausubellab.mgh.harvard.edu/
 http://chemicalbiology.mgh.harvard.edu/labs-ausubel.htm
 http://molbio.mgh.harvard.edu/laboratories/ausubel
 https://web.archive.org/web/20160304115806/https://www.landesbioscience.com/article/26579/full_text/#load/info/all

Naissance en septembre 1945
Biologiste moléculaire américain


text:
Browsing Psychology by Subjects
Exploration of basal diurnal salivary cortisol profiles in middle-aged adults: Associations with sleep quality and metabolic parameters
Lasikiewicz, Nicola; Hendrickx, Hilde; Talbot, Duncan; Dye, Louise (Elsevier, 2007-09-27)
The use of saliva samples is a practical and feasible method to explore basal diurnal cortisol profiles in free-living research. This study explores a number of psychological and physiological characteristics in relation to the observed pattern of salivary cortisol activity over a 12-h period with particular emphasis on sleep. Basal diurnal cortisol profiles were examined in a sample of 147 volunteers (mean age 46.2177.18 years). Profiles were constructed for each volunteer and explored in terms of the area under the curve (AUC) of the cortisol-awakening response with samples obtained immediately upon waking (0, 15, 30 and 45 min post waking) and at 3, 6, 9 and 12 h post waking to assess diurnal decline. Diurnal mean of cortisol was based on the mean of cortisol at time points 3, 6, 9 and 12 h post waking. Psychological measures of perceived stress and sleep were collected with concurrent biological assessment of fasting plasma glucose, insulin, blood lipids and inflammatory markers. Blunted cortisol profiles, characterised by a reduced AUC, were observed in the majority (78%) of a middle-aged sample and were associated with significantly poorer sleep quality and significantly greater waist-hip ratio (WHR). Blunted cortisol profiles were further associated with a tendency to exhibit a less favourable metabolic profile. These findings suggest that reduced cortisol secretion post waking may serve as an additional marker of psychological and biological vulnerability to adverse health outcomes in middle-aged adults.
A systematic review and quantitative meta-analysis of the effects of oxytocin on feeding
Leslie, Monica; Silva, Paulo; Paloyelis, Yannis; Blevins, James; Treasure, Janet; King's College London; Department of Veterans Affairs Medical Center; University of Washington School of Medicine
The anorexigenic effects of oxytocin have been widely documented and accepted; however, no study has yet used the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines to compile previous findings in a single systematic review and quantitative meta-analysis. The present review aimed to identify published and unpublished studies examining the effects of oxytocin on energy intake in animals and humans, as well as the factors that moderate this effect. Web of Science, Pub Med and Ovid were searched for published and unpublished studies reporting the effects of oxytocin on energy intake in wild-type animals and in humans when administered in the absence of other active drugs or surgery. Two thousand and forty-nine articles were identified through the original systematic literature search, from which 54 articles were identified as being relevant for inclusion in the present review. An additional 3 relevant articles were identified in a later update of the literature search. Overall, a single dose of oxytocin was found to reduce feeding in animals. Despite several individual studies reporting that this effect persists to the end of the third week of chronic administration in rodent models, overall, this anorexigenic effect did not hold in the meta-analyses testing the effects of chronic administration. There was no overall effect of oxytocin on energy intake in humans, although a trend was identified for oxytocin to reduce the consumption of solid foods. Oxytocin reduces energy intake when administered as a single dose. Oxytocin can inhibit feeding over 2- to 3-week periods in rodent models. These effects typically do not persist beyond the third week of treatment. The anorexigenic effect of oxytocin is moderated by pregnant status, dose, method of administration and diet composition.


Led by UAB Associate Professor of Art History, Cathleen Cummings M.A., Ph.D.
The traditional female garment in much of South Asia – the sari – is one of the oldest known items of clothing still in use. It is also one of the most diverse of garments: its length varying from five to nine yards, the sari is a multifarious creation, appearing in disparate materials, and employing a wide array of designs and weaving and dying techniques. Indeed, there are at least thirty regional sari styles across South Asia, and more than eighty recorded ways to wear a sari. At once associated with traditional, respectable married womanhood, the sari also has claims to urban, middle-class Indian modernity. In this talk, Cathleen Cummings will explore the range of visual, physical, and conceptual manifestations of the sari, and the role it plays in negotiations of Indian womanhood.


text:
The Culture Chronicles
The Culture Chronicles Business A look into the Netflix business model that has made them an easy propaganda pipeline for wealthy entities around the world.
A look into the Netflix business model that has made them an easy propaganda pipeline for wealthy entities around the world.
Posted on February 25, 2022 February 25, 2022 by James T
Tyler S. Farley
Streaming services are relatively new, and the business model isn't fully understood by most folks, sometimes even by those on the inside of the industry.
But the way Netflix works and operates has set them up to become a knowing or unknowing pipeline for easily produced propaganda.
Early on when Netflix first started it's streaming service it was able to secure rights to movies and TV shows on the cheap. Most studios didn't realize the potential of streaming. They had decades of old content sitting unused, so when Netflix approached them and offered pennies for the temporary right to stream it, they quickly jumped on board.
If you remember, this is why in the early days of Netflix they had quite a few newer movies being released all the time.
But that soon dried up as the service grew bigger and those same studios realized Netflix was getting rich off content they licensed to them for cheap. When it was time for renewal, the movie studios jacked the price up and Netflix had to adjust.
They moved to finding foreign or "b movie" style content. They also dabbled in their own productions which have grown as well. But even with that, they are almost always desperate for new content. Subscribers can burn through an entire season of a show in days, which means Netflix needs to constantly add new content to keep subscribers paying.
One way they do this is by buying almost any content that is offered to them from outside producers. It's well known in the industry now that shows and even movies are made specifically to be sold to Netflix. The production team or producer foots the initial bill, then once completed it's shopped to Netflix which has the reputation of buying almost anything as long as it's competently produced and formatted.
But with the huge audience Netflix has, this has made it the perfect target for those who want to produce propaganda or activist messaging and parade it as a regular documentary.
For example, a wealthy billionaire like Bill Gates can easily front the money through a shell production company to make a flattering documentary about himself. Full of how he does so much to help the world and the poor through his philanthropy. Then once completed, it is shopped to Netflix for dirt cheap since profit isn't the goal. Netflix acquires it and now millions of people watch what is essentially a propaganda film.
But this goes far beyond just an individual who wants to bolster their image. Any foreign or domestic interest can front such a production on almost any topic. Even with a budget of several million dollars to produce, the bang for the buck is off the charts.
Customers assume that Netflix documentaries are the "real thing" and that the site hosts controversial topics other media outlets may not. This is actually the complete opposite of reality, but the brand image remains. This makes even a few million dollars investment into making a Netflix documentary more than worth the money for almost anyone looking to push a narrative or ideology. Nothing else even comes close.
Of course, we're not saying everything on Netflix is propaganda. Most of the companies taking advantage of this are just fly-by-night production houses who produce low quality films that are then shown on Netflix as filler. However, this is what makes it all work so well. The most successful propaganda platforms are actually 99% real and only 1% propaganda. Something Netflix has achieved almost perfectly either by chance or by design.
Thanks for reading: If you prefer, you can subscribe and follow our content on Substack. It's free!
If you want to learn more about our site and what we do, click here.
Finally, if you enjoy this article please make sure to share it. It really helps.
Be prepared. Global cyberattacks blamed on Russia as "retaliation" for sanctions appear to be the most likely scenario to play out next.
The media's packaged "hero" stories coming out of Ukraine are so it will be easier to sell U.S. military intervention when the time comes.
The current mainstream media narrative (propaganda): Government is the victim. Censorship is good.
The Twitter files open high-ranking government officials to billions in legal liability for violating the rights of Americans.
October Shock: China blockades Taiwan. Russia declares all-out-war in Ukraine. Trump indicted. Euro-energy shortage. Oh yeah, and U.S. midterms.
Trump will be arrested. The plotters behind the unlawful FBI raid are deciding whether to do it before the midterms or after.
World leaders keep warning citizens about upcoming hard times and "sacrifice" for the greater good. This is exactly how they sold the lockdowns, but this time it will be to implement rationing of food and energy.
Elon endorsed Bitcoin, then said it was too harmful. Elon said he would buy Twitter and use it for good, then said forget about it. Elon courted the MAGA crowd, then said Trump needs to go. Notice a trend here?
Armchair psychology: It seems Hunter Biden has a subconscious desire to bring down Joe Biden as payback. What else explains him "losing" all these laptops filled with damning material.
What happened in Sri Lanka shows that when united, the government's power over the people is mostly an illusion. It's like the lion tamer vs the lion.
It's widely accepted the government created the crack epidemic and ruined millions of lives. So why is it so hard to believe that they might groom a mass shooter every now and then?
In most countries, state-run propaganda tries to convince you how great the country is. In America, the state-run media tries to convince you how evil the country is. Why is that?
Support Our Content
Just because their first attempt failed, there's no reason to assume the FBI has given up trying to oust Trump.
The framing of every covid mandate as a way to "protect others, not yourself" was just a backdoor method to demonize anybody who opposed or questioned them.
Three questions nobody can answer about the new covid-19 vaccine, including what's even in it.
Are the experts wrong again? Did the "second wave" already happen in March and April after the first wave in late 2019?
Favorite sites Breitbart ZeroHedge Washington Times


Hechinger Report: Common Core's Unintended Consequence?
Last year, Melody Arabo had the hardest year of her 13-year teaching career. The program she and her colleagues had been given to teach third-grade math at Keith Elementary just outside of Detroit was supposed to match the new Common Core standards students will be tested on this coming spring. But the workbooks still covered some of the old standards, and the daily lessons all but ignored some of the new standards, such as how to measure to the nearest half-inch.
For more, please go to Consequence?


Published 04/23/2019 05:00:31 pm at 04/23/2019 05:00:31 pm in Diy Light Fixture Parts.
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text:
Devin Nunes
Nunes tells Schiff he needs 'rehabilitation' after IG report: 'Admit you have a problem'
By Ronn Blitzer | Fox News
Rep. Devin Nunes: We need to know what the FISA court is really doing
California Congressman Devin Nunes, Republican ranking member of the House Intelligence Committee demands Schiff to call on IG Horowitz to testify before House Intelligence Committee.
House Intelligence Committee ranking member Rep. Devin Nunes, R-Calif., told committee chairman Rep. Adam Schiff, D-Calif., that he is "in need of rehabilitation" after a Justice Department Inspector General report on the FBI's Russia investigation and its use of the Foreign Intelligence Surveillance Act (FISA) contradicted Schiff's past assertions.
In a 2018 memo, Schiff dismissed Nunes' concerns about the FBI's use of a FISA warrant to monitor former Trump campaign adviser Carter Page. The IG report confirmed that the FBI's warrant applications included 17 "significant errors and omissions," including a doctored email and reliance on unverified information from British ex-spy Christopher Steele.
COMEY ADMITS ERROR IN DEFENSE OF FBI'S FISA PROCESS AFTER IG REPORT: 'I WAS WRONG'
"After publishing false conclusions of such enormity on a topic directly within this committee's oversight responsibilities, it is clear you are in need of rehabilitation, and I hope this letter will serve as the first step in that vital process," Nunes said in a Sunday letter.
Schiff's memo downplayed Steele's role and denied FBI wrongdoing, saying, "FBI and DOJ officials did not 'abuse' the Foreign Intelligence Surveillance Act (FISA) process, omit material information, or subvert this vital tool to spy on the Trump campaign." Schiff also claimed at the time that the DOJ "made only narrow use of information from Steele's sources" for the Page warrant.
Nunes listed these statements and others, such as how the FBI conducted a "rigorous process" when vetting Steele's information, noting that "[t]he IG report exposed all these declarations as false."
IG Michael Horowitz's report indicated that Steele's information was not properly vetted, yet was key in convincing attorneys to give the go-ahead to the FISA warrant application, which was previously deemed a "close call."
READ: DOJ IG HOROWITZ STATEMENT TO SENATE JUDICIARY COMMITTEE ON RUSSIA PROBE REPORT
Nunes recognized Schiff's acknowledgment of the "issues and errors" described in Horowitz's report, but said that his opposition to concerns raised by Attorney General Bill Barr and Connecticut U.S. Attorney John Durham -- who is conducting a broader probe of the Russia investigation's origins -- "makes it clear your rehabilitation will be a long, arduous process."
Nunes cited Schiff's failure to use his committee to conduct proper oversight while using it "as a launching pad to impeach the president for issues that have no intelligence component at all." He accused him of "hijacking" the committee, claiming, "As part of your rehabilitation, it's crucial that you admit you have a problem."
Schiff's office did not immediately respond to Fox News' request for comment about the letter, but in an interview with "Fox News Sunday," Schiff acknowledged the FBI's issues as described in Horowitz's report, and claimed he "would have called out the FBI" had he known of them.
The GOP ranking member called on the Democratic chairman to call Horowitz before their committee "at the nearest opportunity." Horowitz has already appeared before the Senate Judiciary Committee, and is scheduled for another hearing before the Senate Homeland Security Committee.
Fox News' Brooke Singman contributed to this report.


text:
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Nomadland is a 2020 American drama film directed by Chloé Zhao, who also wrote, edited, and co-produced. The film is based on the 2017 non-fiction book Nomadland: Surviving America in the Twenty-First Century by Jessica Bruder, and stars Frances McDormand as a woman who leaves her small town to travel around the American Midwest.
The film had its world premiere on September 11, 2020 at the Venice Film Festival, where it won the Golden Lion. It also won the People's Choice Award at the Toronto International Film Festival, making it the first film ever to win the top prize at both Venice and Toronto.[3] It is scheduled to be theatrically released in the United States on December 4, 2020, by Searchlight Pictures. The film was acclaimed by critics, with major praise drawn towards Zhao's screenplay and direction, as well as McDormand's performance.
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La directive européenne 2006/25/CE, relative à l'exposition des travailleurs aux rayonnements optiques, prévoit l'évaluation des risques des situations de travail. Elle est particulièrement importante dans l'industrie des arts du spectacle où des expositions intentionnelles à des projecteurs peuvent être exigées pendant des périodes de l'ordre de 8 heures par jour. L'objectif de la présente étude était de fournir aux éclairagistes des informations, relatives aux risques associés aux projecteurs, afin de les aider à évaluer les risques a priori d'un plan lumière. Elle a consisté à déterminer les risques de 63 projecteurs différents puis à les répartir dans les 4 groupes de risques définis par la norme EN 62471, à calculer leur distance minimale d'exposition admissible, correspondant à l'utilisation de 1 et de 5 projecteurs pour une durée d'exposition journalière de 8 heures. Cette étude a mis en évidence que les projecteurs sont susceptibles de poser des problèmes sanitaires pour les salariés des arts du spectacle. Le schéma de classification proposé par la norme EN 62471 n'est pas suffisant pour évaluer les risques d'un plan lumière. De plus, la distance d'exposition et la durée d'exposition ne constituent pas des paramètres pertinents pour réduire les risques à des valeurs admissibles.
Salsi, S. , Barlier-Salsi, A. Radioprotection, 2013, http://dx.doi.org/10.1051/radiopro/2013064, 20 p.
Hydraulic injection can be defined as the puncturing of the epidermis by a jet of a fluid under pressure. Hydraulic injection injury is the term used to describe an injury sustained by an individual following an injection of fluid, usually while operating or inspecting pressurised hydraulic equipment. While reported instances of injury through hydraulic injection are comparatively uncommon in the UK, the risk of injury through hydraulic injection is common to all hydraulic equipment irrespective of the system volume and can occur at relatively low pressures. This report and the experimental work it describes offers an explanation of the injury mechanism and the current understanding of medical prognosis of injured parties upon sustaining an injury of this type.
High speed video footage of simulated hydraulic injection injuries was captured in order to illustrate the nature of injuries of this type. This footage will be made available to the public through various industry bodies in 2013.
A man working on a film suffered an electrical shock and was sent to the hospital on Aug. 6, after getting trapped on an electrical platform at a Calgary construction site.
According to a press statement from the Calgary Fire Department, the crew was shooting a video when two workers became trapped on a platform three storeys above the ground. "Apparently, the three men were part of a film crew who were working on a time-lapse video of a construction site adjacent to the platform and were unaware of the electrical hazard," the press release read.
Actsafe summer outreach update AND MORE!
If you've been reading the Actsafe Newsletter recently, you may have noticed that we've run a few pieces on workers working alone or in isolation. It's something that's common in both film and performing arts and can have serious consequences if a worker becomes sick or injured and there's no one available to check in on them. To help address the issue, we've produced a five minute video on Working Alone.
2013-08-10 - Preparations for an evening concert were disrupted at the end of the sound check for one of the bands as a wind gust from an approaching storm blew the overhead lighting and canopy support trusses over. A band member from The After had just stepped off of the stage when the structure toppled. The show was set-up at the Cleveland County Fairgrounds near Shelby, North Carolina.
There's just something about superhero movie summer releases that gets us here at NIOSH excited about safety. This summer the source of our inspiration came from the Man of Steel© movie. In the film, pre-Superman Clark Kent is working as a commercial fisherman (a hazardous job if you're not a man of steel). He risks exposing his amazing abilities when he swoops in to save the workers on a nearby oil rig who are in great danger as the rig implodes around them. The scene is reminiscent of Action Comics© issue #3, the original Superman comic book series dating all the way back to 1938. In Action Comics #3, "Superman Battles Death Underground", (issued 75 years ago this month) Superman is in the right place at the right time to save a coal miner, as well as his rescue crew, from an unsafe mine filled with toxic gas. We see instances such as these riddled throughout comic books and superhero movies. There's always a hero around to save the day.
To protect people from hazards it is common to use safety standards. There is a general understanding in the literature that such standards will contribute to improved safety. In this paper we discuss this issue when several safety measures are present and safety standards apply to a subset of these alternatives. We show that the use of safety standards does not always give the expected effect on safety, as the implementation of safety standards for some measures can reduce investments in safety measures not affected by the standards. If the restrictions are sufficiently strong, the safety standards may lead to a reduction in overall safety. Our starting point focuses on major hazard industries, but our discussion is to a large extent general and could also be applied in other areas.
The UK Lubricants Association (UKLA) has, produced a Do's & Don'ts Poster that can be downloaded from UKLA's website. This poster will help minimise health risks, maintain MWF quality and help prolong machine and tool life.
Masonry is a construction trade with high risk of work-related injuries. This study analyzes 141 recordable incidents that occurred over a period of 3 years in a large masonry company. The incidents were analyzed from three perspectives: First, they were analyzed with respect to the nature of events (falls, overexertion, etc.). Second, the analysis examined the production activity that the injured worker was performing. Third, the incidents were analyzed according to the injured workers' position in the crew – that is, foreman, masons, laborers, and forklift operator. The findings first identify the contribution of the different masonry activities to different types of safety incidents. Three activities – scaffold erection and dismantling, laying block and material handling are responsible for most of incidents and consequences in terms of days away from work and days with modified task. Next, the findings identify the frequency and severity of incidents for the different workers' positions, and the high incident activities for each worker role. The results indicate that the laborers have significantly higher accident rate compared to the masons. The study identifies two new areas of priority for reducing accidents in masonry construction: improving the process of scaffold erection and dismantling, and focusing on reducing laborers incidents. Finally, analysis of incidents by production activities and personnel position is an effective way to identify operations and worker groups that need to be targeted for improvement. Thus, it is strongly recommended that the contractors' incident reporting mechanism captures that information.
Source : Babak Memarian, Panagiotis Mitropoulos, Safety Science, Vol. 59, Nov. 2013, p.179-186, http://dx.doi.org/10.1016/j.ssci.2013.05.013.


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Wormwood je jedanaesti studijski album švedskog black metal-sastava Marduk objavljen 13. listopada 2009. godine, a objavila ga je diskografska kuća Regain Records. Prvi je Mardukov album s bubnjarom Larsom Broddessonom.

O albumu
Album bio je snimanjen u 2009. godine u Endarker Studiju u Norrköpingu. Tekstovi govore o uništenju duše i uma i posvećenosti luciferijanskom prosvjetljenju, no to nije konceptualni album.

U SAD-u je objavljen 13. listopada 2009., a u Brazilu tijekom prosinca.

Popis pjesama

Osoblje

Marduk

 Mortuus - vokali
 Morgan - gitara
 Devo - bas-gitara, inženjer zvuka, snimanje, produkcija
 Lars - bubnjevi

Ostalo osoblje

 Holy Poison Design - fotografije, dizajn

Izvori

Albumi sastava Marduk
Albumi iz 2009.


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Uber Theft: Driver Spikes Water Bottle, Asks to Use Passenger's Bathroom…
by Adam Last updated February 10, 2017
An Uber driver in Florida told her passenger that she picked up at Fort Lauderdale airport (FLL) that she really had to use the bathroom, he was nice enough to offer the one in his home. The next thing he remembers is waking up hours later on his couch. "I'm a nice guy and I didn't think there was any harm" he told the local ABC affiliate. He immediately looked around the house and noticed that a small safe, a handgun, and four years of tax returns were missing. He now thinks she drugged his water bottle.
Security footage showed that the driver spent two hours inside his house. She was picked up by police on Tuesday and has been charged with armed burglary and grand theft of a firearm.
So…don't let your Uber drive into your house (and maybe be cautious of that free water).
Adam is the proud Founder and CEO of both Point Me to the Plane and point.me. An international consultant turned TV programming strategist, Adam currently works full-time on both websites. His obsession with points and miles dates back to his freshman year at college. After browsing Flyertalk and Mileage Workshop, Adam pulled the trigger and signed up for his first Citibank AAdvantage credit card and MCI phone line (yes, landlines still existed). Back then, both deals were churnable and in no time at all, the college freshman had enough miles to travel to Europe and Asia in First Class for free, multiple times. Needless to say, he was hooked! Fast forward a few years and Adam of course ended up in a career with a heavy travel requirement…which meant extra miles for awards! As his colleagues and friends started to hear about and see pictures from his trips, they wanted in on the secret and Adam began to assist them with their bookings, Juicy Miles was born. At the same time, Adam started an email newsletter to prevent those less obsessed co-workers from squandering their point collection opportunities. The bi-weekly email covered everything from upcoming promotions, guidance on maximizing points, and redemption advice. The distribution quickly expanded outside the office and Point Me to the Plane became a BoardingArea blog.
American Says Chinese Govt Blocking Their LAX-Beijing Flight, Delta Smiles
Delta Plans to Hire 25K US Employees Post Trump Meeting…If "Level Playground"
WOW: New, No-Fee Uber Credit Card Gives 4%...


I have a friend who really, really, REALLY needed to vent and so she asked me if I'd post this here for her to, you know, get it out there so she can vent and stuff. Now, I totally didn't write this. Really, I didn't. So, if you think you know who it is, please do me a favor? DO NOT SPEAK OF IT! First rule of Blog Club is you DO NOT TALK ABOUT BLOG CLUB. Also? Tyler Durden is a dweeb. Ahem. Anyways, without further ado: Guest Post. And be sure to give her hugs in the comments, she needs 'em, yo.
My new boss is challenging. And since my job knows I blog (and my boss is local, and we likely have acquaintances in common), the wonderful Domestic Goddess is letting me vent my spleen anonymously here. (Thank you, dear DG!) I don't know how much of my reaction is truly due to the current situation and how much is due to Traumas of Crazy Bosses Past. I can't get any perspective.
In an incredibly fast-paced, stressful work environment, my boss delights in playing "gotcha" when something gets missed or an error is made. Now, I have plenty to learn (still, after 10 months here) about this job, and I'm human and therefore make mistakes. Shiz happens. I'm completely willing to own my mistakes and limitations. But (and this is an important but), ANYONE doing the job I'm trying to do under the conditions I'm doing it is going to miss things, make mistakes, and fail to mind-read the boss exactly. Which lead to yesterday morning.
I left her office feeling like an idiot. What had I missed? Did I really either not remember or misinterpret some vaguely worded instruction? As has happened many, many times in the last few months, I began to internalize the criticism and the familiar voices of self-doubt began to whisper. I've written before about what a trigger it is for me to feel misunderstood or misinterpreted, and being scolded for something that may not have been my fault hooks right into those insecurities.
I stewed for ten minutes or so, and then decided to confront the situation. She's not a bad person, my boss, just moody as hell. She is also under an unspeakable amount of job stress herself – take my situation and double it, easily. There are days that we have a very convivial working relationship. When I had a little breakdown in her office a few weeks ago (in reaction to non-work stresses), she was very supportive and sweet, and I know that in professional situations she appreciates a straight-forward approach.
So I stuck my head in her office and asked if she had a minute. I explained that yes, we talked about this situation on Friday, but it wasn't clear to me that her position was that it wasn't worth my spending my time; that she had conveyed not wanting me to actively pursue it, but not her reasons. I said that I felt as though I just got scolded for not knowing something that … I didn't know because it hadn't been explained. My cool was beginning to waiver juuuuuuuust a touch, so I concluded by simply saying, I find this a difficult situation.
Her immediate reaction was to defend her non-proactive position in this circumstance, which wasn't really my point. But I let her talk for several minutes about how with so many major issues to address, I shouldn't be wasting my time on this side issue. That in a perfect world, being proactive would be fine, but that we don't have that luxury right now. I agreed with her 100% and told her that the problem I was having was with the communication style, not the substance.
I didn't get anything like an apology, though she did say at one point that her intention was not to scold, but to "teach" – to adjust my thinking and priorities into alignment with hers, essentially. I responded that I'm well aware that often the way she conveys information to me is intended to mold my thinking, but that sometimes it's not entirely clear what she's after. The conversation petered out from there, and I expected that the rest of the day would be tense and anxious.
Instead, my anxiety seemed to lift somewhat and I found myself achieving a very-welcome (albeit minor) sense of detachment. My self-esteemed lifted a notch or two. And I actually got some productive work done, which is oftentimes a challenge. In addition, my boss seemed to go out of her way to bestow some friendly conversation my way, as if extending a small olive branch.
I know I'm not out of the woods. I had anxiety dreams about work last night and woke up before the alarm with a mental to-do list playing in my head. The emotions around this situation feel a little like bullying to me, and I don't know whether to trust that reaction. I've worked in some truly abusive situations, early in my career when I didn't know any better or how to stand up for myself, and there are some similarities. But I also value the opportunity I've been given, which is to raise my personal bar significantly and grow professionally in ways that I haven't had in a long time. Plus, y'know, I need to work.
What do you all think of the situation? I need to find a way to detach from the crap that really doesn't have to do with me, but I know I'll continue to find that difficult. What would you do in my place?
« Nominee for the Best Mommy in the World Award 2011 goes to…NOT ME.
Yah. Someone I know (not you, if I do know you) is going through something similar. Friend is doing same job as ever, but has a new boss, who thinks this is spending time on All the Wrong Things. New boss has no perspective on why these solutions were put in place in this work environment–because it solved those problems and so they no longer exist. But–if structures are removed–problems will probably return. And then they will be my friend's problem also.
So this isn't very comforting, of course, but to say: many places operate like this. That doesn't make them good places to work, but it doesn't make you a bad worker either. And, if your boss was giving olive branch signals, take the "it's meant to mold you to my way of thinking" as actual truth. But the "gotcha" game–is grownup bullying. Great opportunities are beautiful things, but they are best for leaping you to the next, better situation.
Good luck. Hang in there. And–it's not you, it's her.
I TOTALLY know where you are coming from. I have a female co-worked that is just like this. She is so quick to point out small errors that I have missed. I totally don't mind someone letting me know that I have made a mistake, especially if I didn't even realize it, but she always make some snarky comment along with it. What are we in high school? It seems to come in waves with her also. We work in a small office and she makes it very clear that she is all business, no personal anything. We don't even know where she goes on vacation. She's weird. Anyway…one day it all came to a head and I called her out on her behavior. It wasn't pretty to say the least, it escalated, I called her a "high school mean girl" and a bully. She got really defensive, we yelled at each other and then I just ended the "conversation" by leaving her office. Well things were a little tense for a day or two, but I think we really needed to have it out, I really do. She needed to know that she couldn't push me around. I don't really think this probably helped you, but at least you know someone else out there feels for you.
I have a coworker.. She's basically the second most important person in the office.. Well maybe even first, because sometimes she seems to even trump my boss.. and she is moody, and difficult to deal with… and don't get me started on her 'communication' style..
I think you did the right thing, by confronting the situation and getting clarification. People like her don't apologize.. but maybe she'll think about what you said, and work at improving her communication so that her instructions are better understood.
Sounds to me like she has trouble communicating clearly and gets snappish when stressed. Hard as it is, I think you have to be ready for similar situations to come up again and (this is the tough part) let it go. I'm not the thickest-skinned person, either – but I've had bosses and/or coworkers in the past that forced me to let some things just roll off.
I agree with Kristy. Actually, I think you should consider yourself lucky that you can actually approach her and air your grievances. I have had several women bosses who were absolute terrors, so much so that I'm still sometimes nervous about approaching my boss, who is perfectly fine and reasonable.
Do your job the best you can, communicate with your boss frequently, and let the rest go. It's not worth your energy obsessing over it. Good luck!
Thank you all for the feedback. Unfortunately, this week has gone from bad to worse. I'm going to try to get some distance on the situation this weekend and hope to start the new week with a fresh attitude. I appreciate all of the words of encouragement!


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SOUTH SAN FRANCISCO, CA--(Marketwire - April 14, 2010) - Theravance, Inc. (NASDAQ: THRX) announced today that the first patient with opioid-induced constipation (OIC) has been dosed in a Phase 2 clinical study with TD-1211, an orally-administered peripherally selective mu opioid receptor antagonist (PUMA). TD-1211 is a potent, multivalent inhibitor of the mu opioid receptor designed to alleviate gastrointestinal side effects of opioid analgesic therapy without affecting analgesia. This "proof of concept" study is designed to assess the efficacy, tolerability and safety of TD-1211 in patients with OIC.
TD-1211 has been administered to healthy volunteers in ascending single and repeat dose studies evaluating safety, tolerability and pharmacokinetics. The results of these studies showed that TD-1211 was well tolerated at all doses administered, and had a predictable and linear pharmacokinetic profile supportive of once-daily dosing.
"TD-1211 is a multivalent compound that was designed to contact both a primary and secondary binding pocket on the mu opioid receptor," said Mathai Mammen, M.D., Ph.D., Senior Vice President of Research and Early Clinical Development. "The secondary binding moiety confers excellent selectivity over non-opioid receptors, and limits penetration into the CNS. We are excited that our core technology continues to yield promising differentiated clinical candidates for patients in need."
"We are very pleased with the initiation of the Phase 2 study with TD-1211, a compound discovered by Theravance through the application of our multivalent approach to drug discovery," said Rick E Winningham, Chief Executive Officer, Theravance, Inc. "There is a significant unmet medical need as there are currently no oral drugs approved in the U.S. to treat constipation resulting from the chronic use of opioids in treating and managing pain. We look forward to the results of this proof of concept study later this year."
The Phase 2 clinical study is a randomized, double-blind, multiple-ascending dose study that will evaluate the constipation-relieving effects, safety and tolerability of TD-1211 in patients experiencing constipation while receiving chronic opioid therapy. Approximately 50 patients experiencing OIC will be randomized to TD-1211 or placebo in addition to their opioid treatment. Therapy will be administered orally once-daily over 14 days of treatment. The primary efficacy endpoint of the study is the frequency of spontaneous bowel movements (SBMs). The study will compare the frequency of SBMs in patients receiving TD-1211 to those in patients receiving placebo.
Theravance is a biopharmaceutical company with a pipeline of internally discovered product candidates. Theravance is focused on the discovery, development and commercialization of small molecule medicines across a number of therapeutic areas including respiratory disease, bacterial infections and gastrointestinal motility dysfunction. The company's key programs include: VIBATIV™ (telavancin) with Astellas Pharma Inc. and the RELOVAIR™ program and Bifunctional Muscarinic Antagonist-Beta2 Agonist (MABA) program with GlaxoSmithKline plc. By leveraging its proprietary insight of multivalency toward drug discovery, Theravance is pursuing a strategy designed to discover superior medicines in areas of significant unmet medical need. For more information, please visit the company's web site at www.theravance.com.
registered trademarks of Theravance, Inc.
This press release contains certain "forward-looking" statements as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals, plans, objectives and future events. Theravance intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Exchange Act and the Private Securities Litigation Reform Act of 1995. Examples of such statements include statements relating to the goals and timing of clinical studies and product commercialization, statements regarding the potential benefits and mechanisms of action of drug candidates, statements concerning enabling capabilities of Theravance's approach to drug discovery and its proprietary insights, and statements regarding expectations for product candidates through development. These statements are based on the current estimates and assumptions of the management of Theravance as of the date of this press release and are subject to risks, uncertainties, changes in circumstances, assumptions and other factors that may cause the actual results of Theravance to be materially different from those reflected in its forward-looking statements. Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements include, among others, risks related to delays or difficulties in commencing or completing clinical studies, the potential that results of clinical or preclinical studies indicate product candidates are unsafe or ineffective and our dependence on third parties in the conduct of our clinical studies. These and other risks are described in greater detail under the heading "Risk Factors" contained in Theravance's Annual Report on Form 10-K filed with the Securities and Exchange Commission (SEC) on February 26, 2010 and in Theravance's prospectus supplement filed with the SEC on March 19, 2010 pursuant to Rule 424(b)(5). Given these uncertainties, you should not place undue reliance on these forward-looking statements. Theravance assumes no obligation to update its forward-looking statements.


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DEAD & COMPANY ANNOUNCE HALLOWEEN ADDITION TO DIGITAL CONCERT SERIES
Last year's Dead & Company's sold out shows at Madison Square Garden will be released digitally next week. The two shows marked the first time the band had performed since the passing of longtime Grateful Dead lyricist Robert Hunter.
To open the show, Grateful Dead band members Mickey Hart, Bill Kreutzmann, and Bob Weir took to the stage by themselves while their newer bandmates John Mayer, Jeff Chimenti and Oteil Burbridge waited in the wings. The trio launched into "Ripple," one of the most beloved songs Hunter wrote with Jerry Garcia, then the rest of the band joined them mid-song. Like the other shows in Dead & Company's ongoing digital concert series, both live performances will be available through all digital download and streaming services.
One of the concerts was recorded on Halloween, which is one of the most anticipated dates on the Dead Head calendar. Both shows will be release on October 23. And the group's cover of Warren Zevon's "Werewolves Of London" from that show is already available.
Last year's Dead & Company's sold out shows at Madison Square Garden will be released digitally October 23.
The two shows marked the first time the band had performed since the passing of longtime Grateful Dead lyricist Robert Hunter.
One of the concerts was recorded on Halloween, which is one of the most anticipated dates on the Dead Head calendar.
The group's cover of Warren Zevon's "Werewolves Of London" from that show is already available.


So it makes sense to have our name represent what we love, and what we do every day – coach.
Our new website reflects our core business, and our new name reflects our love – Blue Mesa Coaching. Our fundamental value is to Elevate Your Potential. And our business focus is to do just that through excellence in coach training, mentoring, and executive coaching.
Blue Mesa Group began in 2008, and as we have served hundreds of individuals and organizations since. Feedback from clients has signaled that coaching is our sweet spot. Coaching is our contribution to help make the world a better place.
Customized leadership education and development.
We continue to provide leadership consulting, training and team building programs for leaders in organizations who are committed to personal and professional growth.
As we delve into this next chapter of Blue Mesa Coaching, we strive to serve your needs to help you Elevate your Potential. We look forward to continuing our partnership with you.