text:
Levels of Pretreatment Blood Lipids are Prognostic Factors in Advanced NSCLC Patients Treated with Anlotinib
Mengqiu Tang, Chao Song, Yaowen Zhang, Chen Wang, Zhanchun Zhang, and 1 more
published 20 Nov, 2021
Read the published version in Lipids in Health and Disease →
Background: Anlotinib, a small molecule for multi-target tyrosine kinase inhibition, is the third or further line of defense for treatment of non-small cell lung cancer (NSCLC). Results from an ALTER0303 phase III trial revealed that this drug confers significant survival benefits in patients. Although numerous inflammatory biomarkers play a vital role in treatment, none of them has focused on blood lipids before treatment. Here, we explored the relationship between blood lipids and efficacy of anlotinib, with a view of generating insights to guide future development of convenient and individualized treatment therapies.
Methods: We analyzed basal blood lipids, including triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), and high density lipoprotein (HDL), among other variables before treatment, in 137 patients with advanced NSCLC who received anlotinib as third or further-line treatment at the Ningbo Medical Center Lihuili Hospital, between July 2018 and December 2020. We selected the best cut off value for predicting treatment response, generated survival curves using the Kaplan–Meier method, then applied univariate and multivariate Cox regression analyses to assess predictors of survival.
Results: The entire study population recorded median progression-free survival (PFS) and overall survival (OS) of 4 (95% CI 3.142-4.858) and 8.3 (95% CI 6.843-9.757) months, respectively. We observed statistically significant differences across subgroup, between blood lipid indexes with different efficacies, except in the HDL subgroup. The low Disease control rate (DCR) was associated with significantly high TG, high TC and high LDL (P = 0.000). Results from multivariate analysis demonstrated that high TC and high LDL were independently associated with poor PFS or OS (P ≤ 0.003). We used these results to establish a prediction model, and set high TC or high LDL as risk factors, respectively. The outcomes significant difference between 0 and ≥1 scores in PFS (P = 0.000) and OS (P = 0.012).
Conclusions: TC and LDL, before anlotinib therapy, were independent prognostic indicators for patients with advanced NSCLC who received this drug as a third or further-line of treatment. In addition, a risk score of 0 was attributed to a combination between low TC and low LDL, and these patients were exhibited excellent efficacy and survival rates.
Cardiac & Cardiovascular Systems
triglyceride (TG)
total cholesterol (TC)
low density lipoprotein (LDL)
high density lipoprotein (HDL)
anlotinib
prognostic factor
prediction model.
For decades, the rate of non-small cell lung cancer (NSCLC) has ranked highest among malignant tumors, with an overall 5-year survival rate of 20%.1, 2 Most patients are usually diagnosed an advanced stage, making its treatment a challenge. Generally, treatment of NSCLC is stage specific.3, 4 Patients with stage I or II are treated with complete surgical resection, when not contraindicated and mostly obtained good prognosis. However, those with stage III or advanced NSCLC are subjected to local or systemic treatment, including targeted therapy, radiotherapy, chemotherapy or immunotherapy, as these have shown excellent efficacy in patients who missed the opportunity for operation.5–8 Recently, the targeted therapies based on important driving genes mutation have achieved tremendous survival benefits in patients with advanced NSCLC.9–12 However, a large number of patients without gene mutation as well as those who became refractory to the targeted therapy, exhibit poor outcomes, necessitating development of optimum treatment options other than the existing above third-line. To date, discrepancies in the third line treatment methods recommended by the NCCN have limited success of curing NSCLC.13 In China, researchers prefer using an antiangiogenic therapy, called anlotinib, as a third-line of treatment for advanced NSCLC.15 In fact, results from phase II and III clinical trials have shown that the novel vascular-targeting agent (anlotinib) prolongs PFS patients in NSCLC for another 4 months relative to the placebo. Besides, the findings indicated that the drug confers an overall disease control rate (DCR) of 81%, while the overall response rate (ORR) was only 9.2%. Moreover, the shortest and longest response durations among patients who achieved DCR were 1.5 and at least 18 months, respectively.14–17 Considering the huge differences in efficacy of anlotinib, we sought to identify biomarkers that regulate this phenomenon in order to improve prediction for the efficacy of anlotinib.
In advanced NSCLC, anlotinib is a small molecule multi-target tyrosine kinase inhibition of VEGFR1-3, FGFR1-4, and PDGFRα-β, among others.18, 19 It plays a crucial role as a third or further line of targeted therapy and has shown excellent efficacy in treating NSCLC during clinical trials. Anlotinib has also been associated with various adverse reactions, including hyperlipidemia among other symptoms.15, 17 Some previous studies have demonstrated that some elements such as CD31-labled activated circulating endothelial, levels of KLK5 and L1CAM, post-treatment hyperlipidemia, post-treatment hypertension status and pre-treatment ECOG scores, might be potential biomarkers for effectively predicting anlotinib in NSCLC patients.19–22 To date, however, these genetic and cytological factors are expensive and inconvenient to obtain, and none of these evidences have described the potential association between blood lipids before treatment and efficacy of anlotinib in treatment of NSCLC. Therefore, we analyzed differences in basal lipids levels during patient survival as well as the effective ratio, and found that these can be a significant predictor to guide future individualized treatment.
Patient recruitment and selection criteria
We retrospectively reviewed data from advanced NSCLC patients, who received anlotinib as a third or further-line treatment at the Ningbo Medical Center Lihuili Hospital, between July 2018 and December 2020. Participants were included if they: (1) were pathologically diagnosed with stage IV NSCLC (recurrent or metastatic); (2) had a ECOG score of 3 or below; (3) had no history of heart disease, renal or liver failure, or other contraindications to targeted therapy; (4) underwent treatment with anlotinib as monotherapy more than 2 weeks after at least two previous lines of therapy for advanced disease; and (5) their treatment was assessed according to the RECIST 1.1 criteria. Conversely, participants were excluded if they; (1) exhibited no form of hypolipidemic therapy prior to treatment; and (2) had a Body Mass Index (BMI) score higher than 30 at baseline. Finally, a total of 137 patients met the aforementioned criteria and were enrolled in the study.
We collected each patient's basic information prior to anlotinib administration, including age, gender, and tumor stage among others. We also included patients whose baseline laboratory lipid information, namely TC, TG, LDL-C, and HDL-C, were available within 1 month prior to receiving anlotinib. The unit of measurement for lipids was mmol/L.
Categorical variables were compared using either a chi-square or Fisher's exact test. Overall survival (OS) was defined as the time from receiving anlotinib to death or final follow-up date, whereas progression-free survival (PFS) denoted the time from receiving anlotinib to progressive disease (PD) or death resulting from any cause. Both OS and PFS were calculated using the Kaplan–Meier method, and the resulting survival curves compared using the log rank test. Hazard ratios (HR) were estimated using the Cox regression analysis method. Overall response rate (ORR) was taken as the sum of partial response (PR) and complete response (CR), while disease control rate (DCR) was equal to the sum of ORR and stable disease (SD). Correlation between optimal treatment efficiency (%) and baseline lipid stratification was performed using the Chi square test, with multivariate analysis for the most significant variables performed using the Cox regression model. All statistical analyses were performed using packages implemented in R version 3.3.3 (R Foundation for Statistical Computing, Vienna, Austria) and SPSS software (version 20.00, SPSS, Chicago, IL), with statistical significance set at P < 0.05.
Patients' physical and clinical characteristics
A summary of physical and clinical characteristics of the 137 patients included in this study is shown in Table 1. Briefly, all patients' ECOG scores ranged from 0–3, and none of them had received treatment to either increase or decrease their blood lipid levels. The group's median age was 62 years old, while clinicopathological diagnosis revealed that all patients presented more than 4 stages. Squamous and non-squamous cell carcinoma accounted for 51.8 and 48.2%, respectively, and the median line of treatment using anlotinib was 3. The other three items alongside their median values are also listed in Table 1.
Physical and clinicopathological characteristics of the 137 patients included in the present study
N = patients (%)
< 65
≥ 65
squamous
non-squamous
PS (ECOG)
Driver gene
Metastasis sites
≤ 3
73 53.3%)
> 3
Line(s) of treatment
Optimal cut-off values for lipids
We generated ROC curves to determine the optimal cut-off values for the aforementioned blood lipids in all patients under this study. For TG, the optimal cut-off value for TG was 1.82 with an area under the curve (AUC) of 0.639 (95% CI: 0.527–0.751), that for TC was 4.77 with an AUC of 0.700 (95% CI: 0.606–0.795), whereas those for LDL and HDL were 2.965 (95% CI: 0.592–0.797) and 1.095 (95% CI: 0.431–0.654), respectively, with corresponding AUC values of 0.695 0.543. A summary of ROC curves is presented in Fig. 1.
Curative effect analysis
No patient from the analyzed cohort achieved CR (0%), thus the ORR (4%) was thought to be equal to the PR value (4%). SD took a majority of the response. We calculated the curative effect among different lipids groups layered based on their respective optimal cut-off values, and these are listed in Table 2. For TG, a total of 100 patients reached DCR, with the low group (TG < 1.82) comprising a significantly higher proportion (59.1%) relative to the high group (13.9%, P = 0.000). Conversely, the high group exhibited the highest proportion of PD (13.9%), which was significant different from those obtained in PR and SD (P = 0.002). Results from LDL corroborated those of TG and TC (Table 2). However, we observed no significant differences in the curative effect in the HDL group.
Associations among the four lipids with treatment response
< 1.82
≥ 1.82
< 2.965
≥ 2.965
Identification of prognostic factors of layered baseline lipids in the overall population
The study population had a median follow-up time of 16.3 months, and all patients exhibited recurrence. On the other hand, the entire population recorded median PFS and OS of 4 (95% CI 3.142–4.858) and 8.3 (95% CI 6.843–9.757) months, respectively. Results from univariate analyses revealed that TG and TC and LDL were all significant risk factors for PFS, while TC and LDL were risk factors for OS (Table 3). Incorporating the significant risk factors into multivariate analysis demonstrated that high TC and high LDL was independently associated with poor PFS (Table 4). For the results of TC in Fig. 2B and Fig. 3B, moreover, the high TC group showed shorter median PFS and OS rates, at 2 and 6 months, respectively, compared to those in the low group, namely 5.9 and 9.9 months, respectively (PPFS = 0.000, POS = 0.003). Similarly, the high LDL group exhibited significantly shorter median PFS (Fig. 2C) and OS (Fig. 3C) compared with the low group (1.75 months vs 5 months, PPFS = 0.000; 5.8 months vs 9.7 months, POS = 0.029). The high TG group exhibited significantly shorter median PFS (Fig. 2A) compared with the low group (2.0 months vs 5.0 months, P = 0.004) while there was no significant difference in OS between the high and low TG groups (Fig. 3A). Notably, we found no statistically significant differences in neither PFS (Fig. 2D) nor OS (Fig. 3D) between the high and low HDL groups (Table 4).
Results of univariate analysis of factors associated with progression-free and overall survival rates
Variable (N = 137)
95%CI
Univariate (P value)
≥ 3
Results of multivariate analysis of significant factors associated with progression-free survival
Multivariate (P value)
The prediction model by TC and LDL value
We incorporated the significant factors, namely baseline TC and LDL values, into multivariate analysis to identify independent prognostic factors using. The high value was equivalent to a risk factor, and for the presence of each a risk factor, the patients' risk score was raised by 1. Based on this, we found that patient's scores ranged from 0 (extremely favorable) to 2 score (extremely unfavorable). Results indicated that scores of 0, 1 and 2 were significantly associated with PFS (P = 0.000, 95%CI 3.142–4.858) and OS (P = 0.017, 95%CI 6.843–9.757). Specifically, 0 score was associated with superior survival rates while relative to 1 and 2 (Table 5). However, the survival rates showed a cross connection among the three group (Fig. 4A, 4B). Additionally, in grouped comparison, 0 score exhibited no significant differences with score 1 in mPFS (P = 0.198). Therefore, we combined scores 1 and 2 groups into a high score group (≥ 1 score), then re-calculated the survival between 0 score and ≥ 1 score group. Results revealed significant differences in PFS and OS between the two groups as well as the survival curve (Fig. 4C and D).
Median progression-free survival (mPFS) and median overall survival (mOS) for different scores in patients stratified according to presence of different independent prognostic factors obtained from multivariate analysis (TC and LDL)
0(n = 75)
mPFS (months)
mOS (months)
Note: The unit of measurement for lipids is mmol/L. A score of 0 represents low TC (< 4.77) and low LDL (< 2.965) at baseline; a score of 1 denotes low TC (< 4.77) and high LDL (≥ 2.965) or low LDL (< 2.965) and high TC (≥ 4.77) at baseline; whereas 2 represents high TC (≥ 4.77) and high LDL (≥ 2.965) at baseline.
Angiogenesis occupies an absolute position in tumorigenesis and development, paving way for restraining of tumor growth by blocking of the process.23, 24 Particularly, VEGFs and VEGFRs are key family members of regulators of angiogenesis, whose combination reportedly promotes angiogenesis behavior.25–27 Anlotinib, an oral multi-targeted tyrosine kinase receptor inhibitor, has been shown to actively regulate anti-angiogenesis and selectively inhibit VEGFR (2/3), PDGFR (α/β), and FGFR (1–4), as well as other targets.17–19 Numerous studies have demonstrated the role of VEGFs in lipid and lipoprotein metabolism. Particularly, VEGF-A is significantly upregulated during occurrence of heart and blood vessel diseases,28, 29 whereas VEGF-B is basically homologous with VEGF-A.30 In the past, VEGF-C/D were thought to be associated with lymphangiogenesis, with several studies demonstrating that VEGF-D further plays a crucial role in lipid metabolism via its endothelial cell receptors VEGFR-2/3.31, 32 Furthermore, immunohistochemical results have confirmed that VEGF-A, VEGF-D, VEGFR-1 and VEGFR-2 are elevated in hyperlipidemic rabbits.33 Despite VEGFA-D and VEGFR1-4 belonging to the same receptor family, their functions in blood lipids are complicated and contradictory while their regulation is controlled by unknown factors. A part from that, extremely abundant cancer cells were known to exhibit intense lipid and cholesterol and cholesterol attraction, which are satisfied by increasing food intake or external carbohydrates, lipoelasticity or lipid synthesis33– 35. Importantly, this aberrant lipid metabolism not only influences the primary tumor, but also affects exogenous lipid production by the tumor microenvironment thereby predisposing body tissues to malignancy.36, 37 Based on these findings, it is evident that lipid metabolism processes are often upregulated in cancer.
Results of the present study showed that high levels baseline lipids, mainly TC and LDL, shorten survival rates of patients and affects efficacy of anlotinib therapy. Specifically, the present study population exhibited median OS and PFS times of 8.3 and 3.1 months, respectively, which were slightly shorter than the corresponding 5 (PFS) and 9.6 (OS) months from ALTER0303.15 This may be attributed to the fact that the patients included in our research were all diagnosed at stage 4 and were treated with anlotinib as a third or further line, relative to those in ALTER0303 who were at stage 3 or using anlotinib as a second-line therapy. Previous studies have shown that several factors, such as ECOG scores before treatment, hyperlipidemia and hypertension status after treatment, respectively, played some predictive roles in prognosis of anlotinib therapy mainly due to occurrence of adverse reactions.19, 20 However, we found no study that combined basal lipids with prognosis. In the present study, there was no significant difference in survival analysis among different ECOG scores, the reason might be that in order to eliminate data skew, we divided ECOG score 0–1 into a group and 2–3 into another resulted from the lack of score 0 patients, but the other researchers arranged ECOG score 0 into a group appreciably and 1–2 into another because there was no score 3 in their data. We initially analyzed efficacy of anlotinib therapy with different basal lipids level, and results from multivariate analysis demonstrated that high TC and LDL were independent predictors for poor PFS. Moreover, survival data also confirmed that the high basal TC and LDL might result in poor efficacy in curing NSCLS patients treated with anlotinib. Our retrospective study enrolled patients with comparatively advanced status, which may have led to very poor natural prognosis. In addition, the different treatments of posterior line may have influenced the overall survival rates to a varying degree. Based on the reason for the divergence of the multivariate analysis registering as three factors in PFS but just one factor in OS, we established a scoring system with scores ranging from 0 to 2, and comprising basal TC and LDL. During this process, we expected that a high value would represent a high risk and anticipated the significant difference according this model. Although we observed significant differences in PFS (P = 0.000) and OS (P = 0.017) among the 3 groups, the PFS curve with scores of 0 and 1 was so close together that it generated a negative result between them (P = 0.198) during stratified analysis. Considering that the small sample size might have led to the lack of score 1 patients, we reconsidered a high score group (≥ 1 score) comprising both 1 and 2 score groups, and found statistically significant difference in PFS (P = 0.000) between 0 and ≥ 1 scores, as well as in OS (P = 0.012).
Based on the calculated results, we hypothesized that the basal TC and LDL accounts could be potential predictors for choosing anlotinib to treat NSCLC. However, the study had some limitations. Firstly, all patients recruited herein were at an advanced NSCLC stage, suggesting that many uncertain factors may have impacted the observed results. In addition, their diet and nutritional status at that time might also have influenced the recorded lipid indexes. Secondly, it is possible that the subsequent therapy after anlotinib, which involved radiochemotherapy and immunotherapy, may have potentially affected prognosis. Lastly, our sample size was relatively small and may have resulting in a minimal PR and 1 score group, thereby introducing potential bias. And the lack of validation analysis with independent data sets would led to the necessity of high level validation of prediction models in future.
In summary, basal TC and LDL are excellent biomarkers for evaluating patient response to anlotinib treatment during treatment of advanced NSCLC. Patients with high levels of baseline TC and LDL, prior to anlotinib therapy, exhibit both inferior curative efficacy and survival rates than those in the low group. Taken together, the findings indicate that changes in blood lipids during anlotinib treatment are potential prognostic factors for NSCLC.
The study was approved by the Ningbo Medical Center Lihuili Hospital ethics committee. The authors obtained the necessary rights to use patient information for the purpose of the research. The research is a retrospective review, patient names or other identifiers pertinent to patient privacy were anonymized or confidentially maintained.
Tian Chen and Mengqiu Tang contributed to the conception and design of the study. Chao Song and Mengqiu Tang wrote the article together. Gaofeng Liang, Xiaoyu Xu and Chen Wang contributed to thacquisition and analysis of the data. Zhanchun Zhang and Tian Chen participated in revising of the article.
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Editorial decision: Major revision
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"Criminal law is the section of public law that studies the concepts of crime and punishment. It is divided into two as general and special criminal law."
Criminal and Criminal Procedure Law is one of the areas of expertise of ATD Law Firm, which has been operating for more than 3 generations, and which has become one of the distinguished law firms in this field. Our lawyers, who are experts in their fields, provide all kinds of legal support to their clients in criminal cases and prosecution investigations, especially in the Heavy Penal Court, Criminal Courts of Peace and Criminal Courts of First Instance, regarding the types of crimes within the scope of other legislation, especially the Turkish Penal Code No. 5237.
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GRANVILLE — Since the 1960s, Granville's tiny town office has been on a small plot of land with no running water.
Last Wednesday, Granville celebrated the grand opening of its renovated town hall and new town office, located in the town's former schoolhouse. Town officials said Sen. Patrick Leahy was instrumental in landing the low-interest loans and grants that allowed them to complete the project, and though Leahy was in Washington at the time, Marcelle Leahy, his wife, spoke on his behalf at the ceremony on Route 100.


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British financial services provider Standard Life says it is in "advanced" talks to purchase fund manager Ignis from owner Phoenix Group.
The Edinburgh-based firm confirmed the talks after weekend newspaper reports suggested it had tabled a bid of STG400 million ($A727.93 million).
"Standard Life plc notes recent press speculation and confirms that it is in exclusive and advanced discussions with Phoenix Group Holdings regarding a potential acquisition of Ignis Asset Management Limited," it said in a statement on Monday, but gave no indication of price.
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The group added that it would make further announcements if and when appropriate.
Ignis has assets under management of approximately STG67.6 billion, while Standard Life manages over STG244 billion of assets.


text:
African stars headline NBA season restart
The 2019-20 NBA season restart will reach fans in 215 countries and territories in 47 languages on their televisions, computers, mobile phones and tablets, highlighting a whole new game with a more connected and immersive experience for fans. This includes the 88 "seeding games" beginning July 30 as well as behind-the-scenes coverage and interviews from ESPN Wide World of Sports Complex at Walt Disney World Resort in Florida.
Below are international highlights of the 2019-20 NBA season restart:
•	The 22 teams participating in the season restart feature 89 international players from 34 countries and territories, including the record eight international 2020 NBA All-Stars: Giannis Antetokounmpo (Milwaukee Bucks; Greece), Luka Dončić (Dallas Mavericks; Slovenia), Joel Embiid (Philadelphia 76ers; Cameroon; BWB Africa 2011), Rudy Gobert (Utah Jazz; France), Nikola Jokić (Denver Nuggets; Serbia), Domantas Sabonis (Indiana Pacers; Lithuania)*, Pascal Siakam (Toronto Raptors; Cameroon; BWB Africa 2012) and Ben Simmons (76ers; Australia). All 22 teams feature at least one international player, and the Mavericks have a league-high seven international players. The most-represented non-U.S. countries on the rosters of the 22 teams are Canada (15 players) and France (seven players) followed by Australia, Germany and Serbia (five players each). Embiid and Siakam are among the 22 former Basketball Without Borders (BWB) campers on season restart rosters. There are 12 African-Born Players on Season Restart Rosters
•	Select international players have chosen to wear social justice messages on their custom NIKE NBA team jerseys in languages other than English, including Bosnian, French Creole, German, Hebrew, Italian, Latvian, Maori, Slovenian and Spanish.
•	All 88 seeding games will air outside the U.S. and Canada on NBA League Pass. The 88 seeding games include 41 games that will air in primetime in Latin America and 40 games that will air in primetime in Europe, the Middle East and Africa on the NBA's broadcast partners in those regions and NBA League Pass, the most-ever games to air in primetime internationally in a two-week period. The season restart will be available in Africa on ESPN, Canal+, beIN Sports, TV5Monde (Pan Africa), ZAP (Angola and Mozambique) and e.tv (South Africa).
•	While fans won't be physically present at the ESPN Wide World of Sports Complex, more than 300 NBA fans each game will be invited to appear live on the "Michelob ULTRA Courtside" 17-foot video boards surrounding the court. Those fans will have the opportunity to digitally interact with each other throughout the game using Microsoft's "Together mode" to create a virtual experience by removing fans from their individual backgrounds and bringing them together in a shared visual space that will be seen through the broadcast and in the venue. This new experience—the first to go live as a result of the NBA's strategic alliance with Microsoft—gives participating fans the feeling of sitting next to one another at a live game without leaving the comfort and safety of their homes, while players experience their energy and support in-venue.
•	Additionally, all viewers will have the ability to impact visual effects in the venue through a virtual cheering experience. Fans can digitally cheer for their team through the NBA App and NBA.com and on Twitter using team hashtags throughout the game. Virtual cheering will be reflected on the video boards in-venue with graphics and animations that capture the level of fan engagement around the world. Fans will also have the opportunity to see their videos featured through TikTok Challenges. Snapchat's "ground segmentation" augmented reality technology will also give fans an opportunity to explore a virtual rendering of the official court in Orlando via a Lens wherever they are.
•	Outside the U.S., NBA League Pass's coverage of the seeding games will include alternate feeds with new camera angles, enhanced graphics, in-language streams and influencer commentary with a focus on areas such as pop culture and music. All 88 seeding games will be available in English, Spanish and Portuguese. Fans will also have access to in-game polls and quizzes throughout play.
•	The NBA's "Whole New Game" marketing campaign will feature a series of three spots, beginning with "It's A Whole New Game," that will run throughout the season restart on the league's live broadcasts, social media channels and digital platforms globally. All three spots will be translated into more than 10 languages, including Chinese, French, German, Indonesian, Italian, Japanese (subtitles only), Polish, Portuguese, Spanish and Thai. As part of the "Whole New Game" campaign, 22 international celebrities from the world of film, fashion and sports sat down to discuss the teams participating in the season restart and their "3 Reasons to Watch" select teams. "3 Reasons to Watch" content will be aired by the league's international broadcast partners and shared on the NBA's social media channels globally.
•	Rakuten, a global marketing partner of the NBA and the league's exclusive distribution partner in Japan, will host online viewing events on NBA Rakuten, the one-stop destination for fans in Japan to watch NBA games and programming.
•	Domestic and international media who are not on-site have access to virtual media availabilities with players and coaches, as well as footage from team practices on a daily basis.
•	As part of NBA Together, the league's global community and social engagement campaign that aims to support, engage, educate and inspire youth, families and fans in response to the coronavirus pandemic, NBA players, legends and coaches have filmed more than 45 PSAs in nine different languages to share vital health and safety information about ways to reduce risk, proper handwashing and hygiene habits, physical distancing, wearing a facemask and staying physically and mentally fit. To date, these messages have generated more than 65 million video views across the league's global digital and social platforms.
•	The Jr. NBA Global Championship – an annual youth basketball tournament for top 13- and 14-year-old boys and girls teams from around the world – will take place this year as a virtual event that will engage nearly 3,000 youth players from Africa, Asia Pacific, Canada, China, Europe & the Middle East, India, Mexico, Latin America and the U.S. The event, which tipped off last week, will culminate next month with a Jr. NBA Day of Celebration as part of the 2019-20 NBA restart at ESPN Wide World of Sports, which hosted the two previous Jr. NBA Global Championships.
Below please find additional international player storylines from the 2019-20 NBA season:
•	Antetokounmpo, the reigning Kia NBA MVP, ranks third in the league in both scoring (29.6 ppg) and rebounding (13.74 rpg).
•	Gobert (13.71 rpg), the reigning back-to-back Kia NBA Defensive Player of the Year, and Sabonis (12.4 rpg) rank fourth and fifth, respectively, in rebounding. Gobert (69.8%) ranks second in field goal percentage.
•	Dončić (14), the reigning Kia NBA Rookie of the Year, and Jokić (12) rank first and third, respectively, in triple-doubles.
•	Simmons (2.13 spg) leads the NBA in steals. This season, Simmons became the third-fastest player in history to reach 25 triple-doubles, behind Oscar Robertson and Magic Johnson.
•	Ricky Rubio (Phoenix Suns; Spain; 8.9 apg), Dončić (8.7 apg) and Simmons (8.2 apg) rank third, fourth and fifth, respectively, in assists.
•	Buddy Hield (Sacramento Kings; Bahamas) ranks second in three-pointers made with 244.
•	Dennis Schröder (Oklahoma City Thunder; Germany; parent from The Gambia) has the NBA's highest scoring average (19.0 ppg) in games played off the bench.
•	Rui Hachimura (Washington Wizards; Japan; parent from Benin; BWB Global 2016) leads all rookies in rebounding (6.0 rpg) and ranks fifth among rookies in scoring (13.4 ppg).
•	Siakam has recorded career highs in minutes (35.5 mpg), scoring (23.6 ppg), rebounds (7.5 rpg) and assists (3.6 apg).
•	Serge Ibaka (Raptors; Republic of the Congo) is averaging a career-high in scoring (16.0 ppg).
The 22 teams participating in the season restart will play eight seeding games each from July 30 – Aug. 14 at ESPN Wide World of Sports Complex at Walt Disney World Resort in Florida. The seeding games will conclude on Aug. 14. If a play-in is required to determine the eighth playoff seed in either conference, it will take place on Aug. 15-16. The first round of the 2020 NBA Playoffs will begin on Aug. 17.


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Christine Oughton is Professor of Management Economics and Fellow of the Academy of Social Sciences. She received her PhD in Economics from the University of Cambridge. Before joining SOAS she was Professor of Economics and Management at the University of Bolzano and Professor of Management at Birkbeck. Her research focuses on innovation, environmental management & economics, corporate governance, financial inclusion and growth. She was co-investigator on the ESRC Research Seminar Series, Complexity Economics for Sustainability that brought together, academics, practitioners and policy makers on environmental issues, and is co-investigator on a £2m ESRC-DFID project - Financial Inclusion and Growth, focusing on innovation in low-income countries. Christine has published widely on innovation, environmental management & economics, governance and growth. In 2017 she was Research Fellow of the South African Reserve Bank. Between 2012-16 she was Head of the School of Finance and Management and served on the SOAS Board of Trustees.
Dietz, Simon and Michie, Jonathan and Oughton, Christine, (eds.), (2011) The Political Economy of the Environment: An Interdisciplinary Approach. London and New York: Routledge. (Routledge studies in contemporary political economy).
Foxon, Tim and Kohler, Jonathan and Oughton, Christine, (eds.), (2008) Innovation for a Low Carbon Economy. Cheltenham: Edward Elgar.
This list was last generated on Monday, 22nd April 2019, 23:19 Europe/London.


text: Starting the journey.


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The 2011 Beaufort Air Show at Marine Corps Air Station Beaufort already has a headliner.
The Blue Angels, officially known as the Navy Flight Demonstration Squadron, will return to the skies over Beaufort on April 30 and May 1, 2011, according to air station officials. The base hosts the air show every other year.
"The Blue Angels are a familiar visitor to the Lowcountry," said Capt. Josiah Nicely, air station spokesman in an e-mail. "Not only renowned for their aerial prowess, they dedicate time on each visit to meet with community members and stop by local schools to inspire the next generation. Representing both the Navy and the Marine Corps, they are the premier example of the men and women in naval aviation today."
More than 170,000 spectators flocked to MCAS Beaufort in May to see the Blue Angels perform as part of the 2009 Beaufort Air Show, though heavy rains and lightning forced officials to cancel the squadron's performance on the final day of the show.


text:
The 1st London Field Company, Royal Engineers (Territorial Force) was a Territorial  engineer unit of the British Army active during World War I. Formed in 1908, it was based in Bethnal Green in East London.

Origin
When the former Volunteer Force was subsumed into the Territorial Force in 1908 under the Haldane Reforms, the East London (Tower Hamlets) Royal Engineers (Volunteers) became the divisional engineers for the TF's 1st London Division, forming the 1st London Field Company and 2nd London Field Company as well as the Divisional Signals Company. All three sub-units were based at the drill hall at Victoria Park Square, Bethnal Green, that the East London Engineers had built in 1896.

World War I

Mobilisation
The 1st London Division left by railway from Waterloo station on Sunday 2 August 1914 for its annual training camp, which was to be held at Wareham, Dorset. No sooner had it reached camp than it received orders to return to London for mobilisation. This process had been carefully planned, so that before war was declared on 4 August the units were already at their war stations, such as guarding vital railway lines, while the rear details at the drill halls completed mobilisation and began recruiting.

On 15 August the TF was ordered to separate men who had volunteered for overseas service from the Home Service men, and on 31 August it was authorised to begin forming Reserve or 2nd Line units composed of Home Service men and recruits. These were distinguished by the prefix '2/', so that the 1st London Field Company became the 1/1st, and its second line was the 2/1st London Field Company in 2/1st London Division. Later, the 2nd Line were made ready for overseas service and new Reserve or 3rd Line units were formed to continue to process of training. The 1st London Reserve Field Company was later numbered 516th Company before being absorbed into the central training organisation.

During the autumn of 1914, 1st London Division was progressively broken up to provide reinforcements for formations serving overseas. 1/1st London Field Company joined the Regular 6th Division in France on 23 December 1914 and remained with that formation throughout the war. When RE field companies were renumbered on 1 February 1917 it became 509th (London) Field Company.

6th Division
6th Division served on the Western Front throughout World War I, taking part in the following operations:
 Battle of Hooge (9 August 1915)
On 9 August 1915 the 6th Division attacked and recaptured the chateau at Hooge. Number 4 Section of the company joined in the attack alongside the 2nd Battalion Durham Light Infantry, and the company suffered its highest casualties in a single day. The work of the company in fortifying the newly captured position with barbed wire received special mention in the report by GHQ. Sapper Berry received the Distinguished Conduct Medal for his actions in the attack.
 Battle of the Somme:
 Battle of Flers-Courcelette (15–18 and 21–23 September 1916)
 Battle of Morval (25–28 September 1916)
 Capture of Lesbœufs (25 September 1916)
 Battle of the Transloy Ridges (9–18 October 1916)
 Fighting on Hill 70, Lens (13–22 April 1917).
 Battle of Cambrai
 The Tank attack (20–21 November 1917)
 Capture of Bourlon Wood (23–28 November 1917)
 German counter-attacks (30 November–3 December 1917)
 Battle of St Quentin (21–22 March 1918)
By February 1918 the 6th Division was manning the Lagnicourt Sector and was there on 22 March when the Germans launched their Spring Offensive which drove the division back and caused 3,900 casualties out of its 5000 infantry. The divisional history records that 'The field companies suffered heavily, and rendered good service as infantry'.  The company war diary for March 1918 stops after the 20th.
 Battle of Bailleul (13–15 April 1918)
 First Battle of Kemmel Ridge (17–19 April 1918)
 Second Battle of Kemmel Ridge (25–26 April 1918)
 Battle of the Scherpenberg (29 April 1918)
 Allied Hundred Days Offensive
 Battle of Épehy (18 September 1918)
 Battle of St. Quentin Canal (29–30 September 1918)
 Battle of Cambrai (8–9 October 1918)
 Battle of the Selle

In November 1918 its commanding officer was Major H. G. Bambridge, M.C., R.E.(S.).

The Territorials were demobilised in 1919.

Last survivor
In August 2002 William Burnett, probably the last surviving member of the company, was awarded the French Legion of Honour.

2/1st London Field Company
See main article 58th Divisional Engineers
2/1st London Field Company served at home with the 2/1st London Division (now numbered the 58th (2/1st London) Division) until February 1916, when the 58th Divisional Engineers left to join 1st London Division (by now numbered 56th (1/1st London) Division), which was reforming in France. It served with that formation for the remainder of the war. From February 1917 it was numbered 512th (London) Field Company.

Later history
See main article Tower Hamlets Engineers
56th (London) Division reformed in 1920 as part of the reorganised Territorial Army (TA). The field companies of the Divisional Engineers were all labelled (1st London), the senior being numbered 216th.

In 1935 the two London divisions were merged into a single formation, and 56th Divisional Engineers became surplus. It was converted into a Corps Troops RE unit (originally 56th CTRE, later 1st London CTRE) at Bethnal Green. On the outbreak of war in 1939,1st London CTRE's companies were dispersed and assigned to other HQs. 216th (1st London) Field Company joined General Headquarters (GHQ) with the British Expeditionary Force (BEF) in France. After the Dunkirk evacuation, it went to the Middle East with III CTRE, which was disbanded in April 1942.

When the TA was reconstituted in 1947, the former 56th Divisional Engineers was reformed at Bethnal Green as 114 (1st London) Army Engineer Regiment with 216–8 Field Squadrons and 219 Field Park Squadron. In 1956 it was redesignated as a Field Engineer Regiment, and again in 1961 as a Corps Engineer Regiment, when 216 Sqn was disbanded.

Memorials
There are several memorial plaques to members of the East London Engineers in the church of St John on Bethnal Green, close to the former drill hall in Victoria Square. One is a brass plate dedicated to the 675 officers, NCOs and men of the 1st London Divisional Engineers who died in World War I.

Notes

References
 Maj A.F. Becke,History of the Great War: Order of Battle of Divisions, Part 1: The Regular British Divisions, London: HM Stationery Office, 1934/Uckfield: Naval & Military Press, 2007, .
 Maj A.F. Becke,History of the Great War: Order of Battle of Divisions, Part 2a: The Territorial Force Mounted Divisions and the 1st-Line Territorial Force Divisions (42–56), London: HM Stationery Office, 1935/Uckfield: Naval & Military Press, 2007, .
 Maj A.F. Becke,History of the Great War: Order of Battle of Divisions, Part 2b: The 2nd-Line Territorial Force Divisions (57th–69th), with the Home-Service Divisions (71st–73rd) and 74th and 75th Divisions, London: HM Stationery Office, 1937/Uckfield: Naval & Military Press, 2007, .
 Maj W.E. Grey, 2nd City of London Regiment (Royal Fusiliers) in the Great War 1914–19, London: Regimental Headquarters, 1929//Uckfield, Naval & Military Press, 2002, .
 Capt F. Clive Grimwade, The War History of the 4th Battalion The London Regiment (Royal Fusiliers) 1914–1919, London: Regimental Headquarters, 1922/Uckfield, Naval & Military Press, 2002, .
 Maj C.A. Cuthbert Keeson, The History and Records of Queen Victoria's Rifles 1792–1922, London: Constable, 1923/Uckfield: Naval & Military Press, 2002, .
 Maj-Gen R.P. Pakenham-Walsh, History of the Royal Engineers, Vol VIII, 1938–1948, Chatham: Institution of Royal Engineers, 1958.
 Titles and Designations of Formations and Units of the Territorial Army, London: War Office, 7 November 1927.
 R.A. Westlake, Royal Engineers (Volunteers) 1859–1908, Wembley: R.A. Westlake, 1983, .

External sources
 British History Online
 Richard A. Rinaldi, Royal Engineers, World War I at Orbat.com
 Richard A. Rinaldi, Royal Engineers, World War II at Orbat.com
 Stepping Forward: A Tribute to the Volunteer Military Reservists and Supporting Auxiliaries of Greater London
 UK War Memorial Register

Military units and formations of the British Army in World War I
Military units and formations in London
Military units and formations in Tower Hamlets
London

redpajama_set_name: RedPajamaWikipedia


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text:
Quantity Over Quality
The pots parable
There's a popular anecdote about a class of pot makers: the class is split into two groups. One is going to be judged by their pots' quality, the other by their quantity. Each of the people in the first group tries to make a single beautiful pot, while the people in the other group quickly churn them out. At the end of the class, the second group not only has the most pots, but also the best ones.[1]
I have no idea whether this actually happened, but I've certainly seen people who have been "working on a novel" for years, and others who have in that time written a lot. If you were to write, say, a short story a month, then by the end of five years you'd have sixty of them, and by that point probably at least a few would have been published.
There's a few ways you could read into this. One is safety in numbers: by creating lots of things, some are bound to be better than others, and you can cherrypick the best ones to share and promote. This is far better than believing you have only one story to tell, and tinkering with it until the day allegedly will come that you deem it finished. Another way of reading into it is that practicing, that is actively making things, whether you deem yourself already accomplished or not, improves your skillset in the process.
I've seen people labour for months over a single song, which is unfortunate given how little anyone else will likely care about such a small thing. I think most people would rather hear several interesting songs than one finely polished song.
Even worse, for the engineers amongst us, all this energy being misdirected into a single project is even more finely poured into a less interesting aspect of it — the quality of the mix, or miniscule refinements of a single sound, rather than the buildup and flow of the sections, or even more importantly, the catchiness of the tunes themselves.
Rough inspiration
Everything was originally mastered on standard tape on a hi-fi cassette deck... With the first track, the tape had chewed in about seven places... It's a retrospective look, and the tape munching was all part of the stuff I was doing, so I've left it in.
— Richard D. James (Aphex Twin), 1993[2]
In some ways, I suspect I'm quite lucky. When I was twelve, first tuning into the radio to discover what music was out there in 1993 Britain, the rave scene was in full swing. The charts were awash with the picks of ecstasy-fuelled party people who prioritised novelty over quality. Three years later, I bought a cassette tape of Amiga mods from the demoscene, similarly made by enthusiastic amateurs having a go at making music, unburdened by an excess of theory or equipment. They'd make a fun, interesting track, then move on to the next one.
Enamoured with those Amiga mods, when I got my first "proper" computer, I started tracking, first in Scream Tracker 3, before quickly moving on to Impulse Tracker. Making slick, highly polished songs wasn't an option, especially as I had no instruments. My weird sound collages woven from short samples of my voice and hitting various household objects were inevitably rough on the ears. But I didn't care. I was having fun.
When I got a DAW, and learnt a little music theory (very little), my music got more "correct", and more boring for it. It took me a while to realise that theory was more like hints and tips, less like hard and fast rules.
Eventually, when I got a modular synthesiser, I made a conscious effort to get back to my earlier mindset. Happily banging out some absolute bangers, without worrying too much about getting the technical or theoretical aspects right. Having fun again, making weird music. I finally had a plan to stick to: use first takes where possible, and don't overthinking anything.
Good enough, move on.
What you really need: deadlines
A movie is never finished, only abandoned.
— George Lucas, paraphrasing an unnamed director
When I got clients, I was blessed with deadlines. I joined Patreon, in part to have even more. I promise my fans at least a track a month. Much like Hiro Protagonist, I don't promise a polished track. I just promise at least one, each and every month. My fans are kind, and give me a lot of leeway. I don't want to let them down. And I imagine that rather than a glossy slab of pop, they'd prefer to hear something interesting that only I would make.
I'm convinced deadlines are not just a blessing, but a necessity. Instead of waiting for some amorphous "inspiration" to strike, they convince you to plonk yourself down and get started. I doesn't matter if you make something bad, no-one else has to see it. Just make something. If it's no good, fine, throw it away and make something else. It usually doesn't take long to stumble onto something good.
At the other end, instead of waiting to achieve "perfection", deadlines require you to let go and move on just as readily as you engage yourself in the first place. They regulate when to start and stop caring about each project. They give you a time to aim for. And for a bigger project, you can add smaller mini deadlines along the way, milestones.
Since then (in the early 2020s), I've tried to focus more on the bigger picture: when the song's getting too repetitive, and needs me to add another layer, or switch over to a different section. I've all but stopped EQing and compressing, mostly just levelling and panning. I try to spend a proportional amount of time on composing the music, writing the lyrics, designing the sounds, and mixing together the result. I think balance is important.
In short, it's an unrealistic goal to try to make something "perfect". To actually accomplish things, I find it's far more useful and practical to aim to make lots of things that are weird, interesting, quirky, fun, catchy, emotional, or thought provoking. Let other people judge how good any of it is, and when they do, don't worry about their opinion. It's too late, you've already moved onto your next project.
We didn't really hang around on tracks. We used to work two, three, four days, and I think "Papua New Guinea" was the longest we ever worked on a track. We worked on it for about a week solid, and it just kept coming, and Brian kept pushing.
— Garry Cobain, The Future Sound of London, 2006[3]
...we said to the studio manager, "If you give us the keys for a couple of weeks, while it's apparently closed, we can do some recording and we'll call it quits." We recorded about nine or ten tracks...
— Mark Archer, Altern-8, 2013[4]
Because we had this deadline to make these records for this double pack, one of the other beauties of it was that we turned the records around really quickly, because we were kind of like "argh, we've gotta get these tracks!" so I think all in all the double pack contained eight tracks, and so we weren't really thinking, and Ripgroove, actually, we done it in an afternoon. It was really quick, it was a really spontaneous moment...
— Timothy Andrew, Double 99, 2021[5]
Art & Fear David Bayles & Ted Orland, 1993, ISBN 0-9614547-3-3
"The Aphex Effect" Dave Robinson, Future Music, Apr 1993
"Classic Tracks: The Future Sound of London 'Papua New Guinea'" Richard Buskin, Sound On Sound, Nov 2006
"Altern-8: Where Were U In '92?" Mark Archer, 2013
"Garage Evolutions: Turn of Speed With Double 99 / RIP Productions" user-612196404, Jul 2021
Workflows: Quantity Over Quality


Would you spend $3.00 to share Jesus' love with someone?
In the last few days, I had the opportunity to tip a server. The steak was good and timely served for my dinner; the meal overall was very nice. An 18% tip for either factor would have been more than enough. But what if I gave a little more?
I have often debated about giving those extra $2-3 dollars. I pine away in mind like an astrophysicist theorizing about black holes, calculating to the penny, how much tip is required….is required…that doesn't sound like Jesus, does it? Giving only what we should, was never Jesus' style. Can you imagine, the widow from Luke 21 giving all she had to the local cafe for the senior's special, then reluctantly dropping 50 cents to cover her $5 dollar meal, and being praised by the Savior of the universe.
So, again I ask, would you give $3 dollars extra to share Jesus' love with someone?
I was blessed to be able to tip a server generously this week…the results were amazing! I not only prayed for the server named Jer, whose wife was sick, but I taught him and two other servers how to pray healing in the name of Jesus. He had tears in his eyes, as he stated how I had impacted his day. I also promised to pray for the eyesight of Nkiso's father, even though he does not believe in Jesus. I left feeling incredibly blessed myself.
Obviously, we can't pay for salvation to be delivered into the hearts of anyone, but if a couple bucks given out of a motivation of love and a generous spirit, buys me the clout to speak life into a young man's day…I'll take that deal anytime!


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Small Molecule Drug Discovery
Preview - Small Molecule Drug Discovery
Methods, Molecules and Applications
Editors: Andrea Trabocchi, Elena Lenci
Bundle (eBook, Paperback)50% Off$260.00$130.00
Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology.
Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery
Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics
Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches
Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules
Researchers, scientists and graduate students in organic synthesis, chemical biology and drug discovery. Researchers and scientists in chemoinformatics, bioorganic chemistry and combinatorial chemistry
1. Synthetic Approaches Toward Small Molecule Libraries
2. Chemical Reactions for Building Small Molecules
3. Chemoinformatics to Assess Chemical Diversity and Complexity of Small Molecules
4. Virtual Screening of Small Molecule Libraries
5. Biophysical Methods for Screening and Characterization of Small Molecules
6. Small Molecule Peptidomimetics: Principles, Molecules, and Applications
7. sp2-Iminosugars as Chemical Mimics for Glycodrug Design
8. Synthesis and Biological Properties of Spiroacetal-containing Small Molecules
9. Centrocountins: Synthesis and Chemical Biology of Nature Inspired Indoloquinolizines
10. PPIs as Therapeutic Targets for Anti-cancer Drug Discovery: The Case Study of MDM2 and BET Bromodomain Inhibitors
11. Discovery of Small Molecules for the Treatment of Alzheimer's Disease
Andrea Trabocchi
Andrea Trabocchi is Associate Professor of Organic Chemistry at the University of Florence, Italy, where his research and teaching activity are focused on organic synthesis and drug discovery. He received training on peptide chemistry at the Imperial College, UK, and obtained the PhD in Chemical Sciences in 2003 from the University of Florence. In 2016 he received the specialization in Clinical Biochemistry from the University of Rome-Tor Vergata. His research interests lie in the area of small molecules, including diversity-oriented synthesis, chemoinformatics and applications in cancer and CNS diseases. Previous editorial appointments included an edited book on Diversity Oriented Synthesis and an authored book on Peptidomimetics.
Associate Professor of Organic Chemistry, University of Florence, Italy
Elena Lenci
Elena Lenci received the Doctor Europaeus PhD in Chemical Science in 2017 from the University of Florence, after spending a research period at the University of Oxford, UK. She is currently a postdoctoral researcher at the Department of Chemistry, University of Florence, developing novel amino acid- and sugar-derived scaffolds for medicinal chemistry projects. In 2015 she was awarded the Reaxys - Italian Chemical Society Young Researcher Award, and in 2017 she received the International Award for Young Chemists "NATCHEMDRUGS". Besides her work in organic chemistry, she has served as a board-member in the Young Group of the Italian Chemical Society since 2016, and as a board member in the Chemical Cultural Diffusion Group since 2019.
University of Florence, Italy


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Visit Foundation Site
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Discover & Celebrate the meaning of
Support Lady Liberty & Ellis Island
A New Way to Experience History
The Statue of Liberty Museum is the most monumental addition to Liberty Island since the Statue herself. More than that, it allows millions more visitors to enjoy the Statue of Liberty experience and be inspired by her history and message of freedom and opportunity. The museum opened May 16, 2019.
MORE PICTURES OF THE FUTURE MUSEUM
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The Americans Who Saw Lady Liberty as a False Idol of Broken Promises
May 28, 2019 | Smithsonian
It was a crisp, clear fall day in New York City, and like many others, Lillie Devereaux Blake was eager to see the great French statue, donated by that country's government to the United States as a token of friendship and a monument to liberty, finally unveiled....Read More
The Statue of Liberty was created to celebrate freed slaves, not immigrants, its new museum recounts
May 23, 2019 | Washington Post
The new Statue of Liberty Museum in New York Harbor boasts a number of treasures: the original torch, which was replaced in the 1980s; an unoxidized (read: not green) copper replica of Lady Liberty's face; and recordings of immigrants describing the sight of the 305-foot monument....Read More
Poet laureate writes tribute for Statue of Liberty Museum
May 17, 2019 | Associated Press
NEW YORK (AP) — At a time when families have been separated at the Mexican border and children placed in cages, the country's poet laureate is invoking an old and welcoming spirit for those seeking to live in the United States....Read More
What the Lady deserves: A glorious new museum shows off the Statue of Liberty; now, combat the scourge of ticket-hawkers at the Battery
May 16, 2019 | NY Daily News
A standing ovation for fashion icon Diane von Furstenberg for leading the effort to create the new $100 million Statue of Liberty Museum, opening Thursday....Read More
New museum celebrating the history of the Statue of Liberty opens
May 16, 2019 | WABC-TV
NEW YORK (WABC) -- She has been turning heads in New York Harbor since 1886, and now, there's another reason to visit the Statue of Liberty: A new museum, which opened to the public on Thursday....Read More
New Statue of Liberty Museum Illuminates a Forgotten History
May 15, 2019 | New York Times
Each year about 4.5 million people shuffle off the ferries that service Liberty Island to see up close the famous torch-wielding Roman goddess towering above them....Read More
Statue of Liberty museum set to open amid immigration debate
May 15, 2019 | Agence France-Presse
The Statue of Liberty, which has welcomed generations of immigrants to US shores, is getting a new museum at a time when immigration is an explosive topic....Read More
Apple contributes to new Statue of Liberty audio tour and AR app
May 14, 2019 | Apple Insider.com
Called "Statue of Liberty," the app is the brainchild of renowned fashion designer Diane von Fürstenberg, who spearheaded a three-year fundraising initiative to build the new Statue of Liberty Museum slated to open its doors on Liberty Island on Thursday....Read More
Diane von Furstenberg Talks Bringing the New Statue of Liberty Museum to Life
May 13, 2019 | Harpers Bazaar
In 1976, Newsweek famously anointed Diane von Furstenberg "the most marketable woman since Coco Chanel. Just six years after immigrating to New York from Belgium, von Furstenberg had sold more than five million of her signature wrap dresses....Read More
A tribute to Lady Liberty
May 12, 2019 | CBS Sunday Morning
This week the $100 million Statue of Liberty Museum opens on Liberty Island in New York Harbor. It tells the story of the creation of Frédéric Auguste Bartholdi's statue back in the 1800s - a gift of France - and also the story of how it became a symbol of America, of inclusion, of liberty....Read More
A New Museum Sheds Light on the Statue of Liberty
May 2019 | SMITHSONIAN MAGAZINE
When the French sculptor Frédéric-Auguste Bartholdi (1834-1904) sailed into New York Harbor just before dawn on June 21, 1871, he was seized by a "marvelous feeling of movement, animation."....Read More
The Statue of Liberty Museum set to open with original torch, 'soaring' theater space
April 16, 2019 | am New York
Almost three years ago, dignitaries broke ground on the new Statue of Liberty Museum on Liberty Island. Finally, next month, it will open to the public for the first time....Read More
See Behind the Scenes as the Statue of Liberty's Original Torch Moves to Its New Home
March 15, 2019 | TIME
Coated in its signature green patina, gazing over New York City with its burning torch held high, the Statue of Liberty's image reoccurs in popular and commercial culture...Read More
Become Part of Her Legacy
The Statue of Liberty-Ellis Island Foundation is inspired by moments in history when private citizens, sponsors and visitors from around the world joined together to preserve and maintain an exceptional thread in the fabric of our nation. From original construction of Lady Liberty to raising money for the pedestal, as well as the centennial campaign to restore Liberty's glory, generosity has been key to the preservation and enhancement of the Statue of Liberty. Become a part of this inspirational history by making a donation today to The Statue of Liberty Museum.
Become part of history today!
It is with tremendous gratitude for the extraordinary past support that the Foundation moves forward with confidence toward this transformational project. Thank you to all the major donors who have already contributed to this project.
View our Major Donors
© 2016 The Statue of Liberty - Ellis Island Foundation, Inc. All Rights Reserved.
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25 (Possible) Reasons You Are (Still) Single
March 7, 2012 by Katherine Butler
Real-life quotes explaining why we are alone.
Advice-givers are crafty in their visage. They lure you into a state of complicity by appearing as kindly parental figures who just want you to succeed in life. But the moment you lean in to hear their advice, they morph into their deadly true form. Advice-givers attack when you least expect it, hurling unsolicited bits of advice at your head like bees out of a shaken hive.
No one seems to incite the advice-givers more than the single woman over the age of 25. No matter how successful, happy, or healthy she may be, someone, somewhere is wringing his or her hands over the tragic state of her solitude. She can't fight the advice-givers with crazy talk about the publication of her amazing new book, her fulfilling work with Habitat for Humanity, or – God forbid – her recent amicable breakup with her nice-enough boyfriend. She's alone and doesn't need to be! If only she could just fix this one major flaw about herself.
Naturally, advice-givers have issued forth a myriad of guidance throughout the ages. We polled our friends and readers to capture the best, real-life bits of counsel they have ever received. And then we took off the filters to say what the advice givers really wanted to say.
1. "I was told that I don't smile enough. So I need to make sure that I'm smiling all the time at the grocery store and Starbucks." (No one likes a moody bitch.)
2. "I was told by a manicurist no one would ever propose to me with 'those hands' and that I needed to come in for more manicures." (Just make perfect, plaster casts of your hands and wield them instead.)
3. "I was told that I needed to need to straighten my curly hair because it's too sexy and has too much personality. Didn't I know that men are scared of curls?" (Curls are trampy.)
4. "I was told my hair was too straight and limp to attract a man. Men like curls because curls mean fertility." (Curls are youthful and sexy. Strike above translation.)
5. "My mother is convinced that I appear too closed off and that I need to look more approachable. She suggests that I walk slowly down the street and make eye contact with as many men as possible. She doesn't seem to understand that if I do this in Manhattan, I'll eventually look like the Pied Piper with a trail of creepy men following me down the street." (Be confident, but don't get killed.)
6. "I was told by a friend that my excellent posture was the reason for my state of singledom, that the very carriage of my head was enough to make people dislike me. She suggested that I cultivate a more vulnerable look, particularly if I wanted to marry eventually. Her reasons were that women are much nicer to each other when they don't feel threatened by competition, and it's a well known fact that men simply aren't drawn to confident women." (Be confident but don't show it and slouch…a lot.)
7. "I was told that I'm too tall and carry myself too well. It intimidates men. Also, I am not to wear heels since being taller than a man makes him feel inferior. And short." (Slouch, dammit, slouch!)
8. "I was told by a male friend that my upper arms weren't toned enough to attract a good-looking guy. 'You're so pretty. Now if you just got these arms under control, you'd be really hot.' Let me add that I was a size 4 when he said this to me." (Size 4 is the new size you're-so-fat.)
9. "I had a boyfriend who told me I should cover my arms because of all the freckles. (He had freckles.) This was right before he told me, when I was naked on top of him, that I should 'really tone up'. (He was not toned up.)" (Fat is only acceptable on a freckled bro-dude.)
10. "A cousin assured me that the secret to catching a man was simple. My smile had to light up a room upon entry. I needed to pause in between sentences so I didn't babble and listen attentively. I was to cast demure looks about the room. I was to breath slowly, stand straight, and walk briskly with my shoulders back. Yes, she was quoting The Rules at me, and no, I didn't point out that she herself was twice divorced." (Don't listen to your cousins.)
11. "I was told not to write too much of anything online or be too funny. The message I took from that was vague was sexy." (We all just died alone.)
12. "I was told that I was too nice and too prudish. The actual quote was 'Just be a little sluttier and a little bitchier.'" (We can't hear you, we're dead, remember?)
13. "Apparently, my sassy attitude makes men uncomfortable. If I were nicer to men, they'd like me more." (Now we're just turning over in our graves. Our lonely graves.)
14. "I was told to wear a watch so men know I take life seriously and that I'm someone to be taken seriously. A watch gives you a sense of organization and adulthood. You're not just the woman he has sex with – you're a woman who takes care of herself with a watch." (This advice was sponsored by Rolex.)
15. "I was told that I intimidate men. I only attract douches because all the nice ones are too scared to approach me." (You're a bitch, so you're alone.)
16. "I was told that my easy-going attitude made me look like a push-over to men. And since all men want a challenge and/or a saber-toothed tiger to wrestle, I needed to bitch it up before my biological clock kicked out." (You're not bitchy enough, so you're alone.)
17. "My father told me to get rid of my big dog because she intimidated all the men I dated." (Your dog is now a bitch.)
18. "For a few weeks, I dated Jason, aged 40. We stayed friends after we stopped kissing. He constantly told me that at my age – I was 35 – I needed to be going out with guys in their late 40s, at the youngest. 'Guys my age want girls in their 20s. You're more age-appropriate for 45 plus.' After he said this three or four times, I decided I'd had enough of Jason. But I did wonder if he eventually saw on Facebook that, three years later, I married a really great guy who was two years younger than he." (Facebook has validating benefits.)
19. "My great aunt told me that I should masturbate before I went out with a new guy so I didn't feel too tempted to be too sexual on the first date." (No word on what's "too sexual" for a first date, but high-five, great auntie!)
20. "I am too open about enjoying sex in conversation. Men don't want to think of a woman having been with anyone else in the past." (No word on if this advice-giver is Rush Limbaugh.)
21. "I was told by a male 'friend' that no self-respecting guy would marry me if he knew how many sexual partners I had accumulated. Even though I knew it was stupid, I still nervously confessed my number to my boyfriend when things got serious. Not only was he impressed, he still managed to ask me to marry him six months later." (Three cheers for Mr. and Mrs. Awesome Sex Life!)
22. "My dad told me to take it easy with my boyfriend because, and I quote, 'why should anyone buy the cow when they can get the milk for free?'" (Dads are cute?)
23. "My grandmother told me to kiss as many boys as I wanted because 'you don't want to spend decades kissing a fish.' I tried not to think about my grandfather when she mentioned this." (Grandmothers are cuter.)
24. "My now-married friend Angela says to always sleep with the guy by the third date to see if we are sexually compatible. But how do you know anything by the third date? And how can you know from one sexual interaction with someone you barely know whether or not you're sexually compatible?" (Hats off to Angela, who boldly went where many men have gone before.)
25. "I was told that if I just stopped being me, maybe I'd find someone." (That about says it all.)
Images james_sickmind/ james_sickmind /gareth1953
Tags: dating, katherine butler, marriage, relationships, Sex, single
Katherine Butler
Katherine Butler is the Beauty Editor of EcoSalon and currently resides in Los Angeles, California.


Are you called the Eastside Girls Lacrosse Club, the Eastside Eagles, the Lake Sammamish Hailstorms, the Lake Sammamish Eagles, or what??
We are the Eastside Girls Lacrosse Club, which is an all-volunteer, non-profit organization, established in 2002, to promote the sport of lacrosse on the Eastside. We are an affiliate of US Lacrosse of WA and a member US Lacrosse - the national governing body for the sport. Our teams now go by the name of the Lake Sammamish Eagles (a combined name from our merged youth and high school teams).
Does it cost to join a club or team?
Yes, when registration opens for a season, this prices are shown.
Why do players have to join US Lacrosse?
It is a requirement in order for us to maintain our insurance coverage. US Lacrosse provides insurance riders to our club for practices and games at the facilities we use. There are other player benefits as well.
Where can you get equipment and how much does it cost?
Local stores include Breakaway Sports. Some major sports stores carry lacrosse equipment or you can also buy it online. For girls: stick, mouth guard and protective eye wear. Prices vary but you can plan on about $80-$150, including sticks. Remember, there is a difference between a girl's and boy's stick. Soccer shoes are ok, baseball cleats are not.
Our club owns all the uniforms used by high school teams. We allow each player to use a uniform and hold a deposit for the duration of the season. 5/6 and 7/8 uniforms are purchased each year and the price is added at time of registrtion. The 3/4 girls play in t-shirts which are supplied by the club.
How do I know if a player is eligible?
EGLC accepts players in the Lake Washington and Northshore school districts (7th - 12th grade only). We cannot allow players who attend a school that offers lacrosse for their grade level.
Lacrosse is a spring sport with practices beginning in late February, games in March and the season ends in early May for the 3-4 teams, and late May/early June for the older age groups (high school depends on if they qualify for playoffs, and how far they go.) For grades 3-8, practices are usually held twice a week at Marymoor park (most teams), or the Bothell/Woodinville area if we get critical mass for kids to form "North" teams. Games at this level are normally on weekends. The high school typically practices 5 times per week at Marymoor, with games normally on weekdays. Final practice schedules are determined by the coach. Games are at sites throughout the greater Seattle/Sound area. It is also an all-weather sport meaning rain doesn't stop us (unless fields are closed by local park and recreation departments or if safety is an issue).
Games are played throughout the Seattle/Greater Sound area. Home games will typically be at Marymoor Park. In addition there are jamborees where several games are played in the same day. Carpooling for all our games is recommended. Transportation issues should not be a concern for anyone considering playing.
Is there a difference between the boys' and girls' games?
Yes! Not only do the rules differ, but the equipment does too. Perhaps one of the biggest differences is that boys' is considered a contact sport (checking allowed), while girls' allows only limited stick checking, and not until the 7th grade level.
How many players do you need for a team?
For the 5/6th (U13) and 7/8th (U15) grade teams, there are 12 players on a team during play. For these teams, EGLC targets to fill each team with a roster of 17-20 girls.
For the 3/4th (U11) grade teams, there are 8 players on a team during play. For these teams, EGLC targets each team with a roster of up to 12-14 girls.
Lacrosse is a contact sport. How safe is it?
EGLC is committed to maintaining the safety of the players above all else. Contact is limited by rule for Youth/Middle School play. There is NO stick contact or "checking" allowed at the 3/4 and 5/6 level of play. Checking is the striking of an opponent's stick head in an effort to dislodge the ball. Stick checks should be controlled, short, quick taps. A defender may never check toward the head or body. The modified version of checking is employed at grades 7 and 8. A defender may not check a stick head that is above the opponent's shoulder. To counter the advantage this gives the player with the ball, a 3-second count is employed when the defender has both hands on her stick and is in good position to check a stick that is above the ball handler's shoulder. If the player with the ball doesn't reposition her stick away from the defender or pass the ball by the end of the 3-second count, it is considered a minor foul and possession is awarded to the defender.
Below is a summary of the key sections, but if you want full details you should look at the official Rule-book for your age group, which you may download at the above link.
The Crosse (stick): The field crosse must be made of the following basic materials: composite, metal alloy (handle only), rubber, wood, gut, leather, fiberglass, nylon, plastic and any other synthetic material. (Recessed metal screws may be used to affix the head to the handle.) The head of the stick shall be triangular in concept and shall be affixed to the handle in such a way that it shall basically be in the same plane as the handle. The pocket of the stick shall be strung with four or five longitudinal leather and/or synthetic thongs, 8-12 stitches of cross-lacing and no more than 2 "shooting/throw" strings. Mesh pockets are not allowed. The crosse shall not have sharp or protruding parts or edges, and shall not be dangerous to players in any way. The crosse's overall length shall be between 35 1/2" minimum and 43 1/4" maximum.
The Ball: The ball shall be yellow or bright orange (similar to Pantone #811) color, and meet the current NOCSAE lacrosse ball standard. Beginning January 1, 2014, the text on the ball must state "Meets NOCSAE Standard."
Mouthpiece (mouth guard): All players must properly wear a professionally manufactured intra-oral mouthpiece that fully covers the upper jaw teeth. The mouthpiece shall be of any readily visible color other than clear or white. It must not be altered to decrease protection, and there may be no protruding tabs for field players. It is recommended that the mouthpiece be properly fitted, for example, constructed from a model made from an impression of the individual's teeth, constructed and fitted for the individual by impressing the teeth into the mouthpiece, or provided by a dental professional.
Eye Protection (goggles): All field players must properly wear eye protection. Eye protection must meet the most current ASTM Specification Standard F803 for women's lacrosse, must be tested by an accredited testing facility, and must be listed on the US Lacrosse web site.
Other Personal Equipment: Close-fitting gloves and soft headgear may be worn by all players. Face masks are not allowed. Further protective devices necessitated on genuine medical grounds may be used by players, providing that the officials agree that they do not endanger other players. All protective devices used should be close fitting, padded where necessary, and not be of excessive weight. Players may only wear securely taped Medic-alert jewelry with information visible and close-fitting cloth sweatbands. Any other adornment will be considered jewelry and may not be worn. Barrettes are legal as long as they do not endanger other players. No equipment, including protective devices, may be used unless it complies with the rules and manufacturers' specification and is deemed not dangerous to other players by the officials.
Footwear/Cleats: Players must wear composition or rubber soled shoes. No spikes are allowed. Plastic, leather, or rubber cleats-studs may be worn. Shoes and socks are not required to be identical for team members.
Visible Undergarments (athletic wear under uniform for torso, legs, etc.): All visible undergarments worn under the kilts/shorts/shirts must be of one solid color, and must be white, gray, black or one of that team's uniform colors. All team members who choose to wear visible undergarments must wear the same color. This does not apply to medical sleeves.
Goalkeeper Equipment: The goalkeeper must wear a helmet with face mask and properly secured chinstrap, a separate throat protector, padded gloves, a mouthpiece, and a chest protector. In addition, for high school level and below the goalkeeper must wear padding on the shins and thighs. The protective helmet, designed for lacrosse, must meet the NOCSAE test standard. It is recommended that the goalkeeper wear padding on arms and shoulders. Leg padding is recommended for goalkeepers above high school level. This padding must not excessively increase the size of these body parts. Body padding must not exceed the thickness of legal goalkeeping gloves–1" padding. Gloves must not contain any webbing and must not excessively increase the size of the hands as they are presented to the ball.
What rules are followed by the Eastside Girls Lacrosse Club?
The league recruits refs to be trained via WWLUA clinics to become junior, apprentice, local and district umpires. Trained and certified referees are paid per game fees along with travel fees. We encourage family members to fully learn the game of girl's lacrosse by going to the WWLUA training. Please contact your team manager or a board member for more information or go to www.wwlua.org for more information about training dates.
What is the playing time philosophy?
The main goal of EGLC is to grow lacrosse on the Eastside. With that in mind, we accept all players regardless of experience, until each team is full. Full teams are typically comprised of not less than 15 or more than 20 members. In addition, we offer equipment and registration grants.
A player's field time will depend on their athletic ability, their commitment to learn the sport, practice attendance and general attitude. We play to win - and make our best efforts to play everyone.
How can we find out about the sport without joining the team or buying equipment?
Who do I contact if I have a question, comment or complaint?
If it is specific to your player's team, we urge you to contact the coach or assistant coach(es). They provide contact information at the beginning of the season. If it is specific to the Club, or you feel a team issue needs to be addressed by the board, you should contact the club board president.


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Location: Ashbury Towers
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