Byrne, Michael, ed. (2015) How to conduct research for service improvement: a guidebook for health and social care professionals. Tullamore: HSE.
• Learn about evidence-informed decision-making, and why research is an essential element of it.
• Understand the different scenarios when using evidence can help you, as well as the types of evidence you might need at different stages of development.
• Explore different types of evidence, how to choose the most appropriate and how to judge its quality.
• Get advice on finding the right evidence to support your case, and how to get your message across once you have it.
If you have done a piece of research that may be of interest to others working in the drugs and alcohol area you can submit it to our collection by sending us an email at drugslibrary@hrb.ie. We are happy to take small pieces of research or evaluation that you have done in your organisation or articles that you have written for newsletters etc. Please get in touch if you have any questions.
'Building the Foundations' includes three modules to enable researchers to assess their current level of skill in literature searching, find out more about resources and get started planning a search.
Within your topic you must find a question, which identifies what you hope to learn. Research questions need to be shaped and crafted. Start with what interests you, and refine it until it is workable. A strong research idea should pass the "so what" test. Think about the potential impact of the research you are proposing. What is the benefit of answering your research question? Who will it help (and how)?
Plan your search strategy by framing your question.
Use PICO to break down your topic into separate 'concepts' to research interventions.
• Lenus: the Irish health repository contains HSE publications and the freely accessible collected output of more than 130 Irish health organisations.
• Trip Database is a tool for you to find and use high-quality clinical research evidence.
Not all references in databases provide access to the full text of a publication. If you come across an article that you need for your research you may have access through your organisation's library (such as the HSE library). If not please contact us to see if we can be of help obtaining the article.
In order to put your research into context it is important to briefly describe what others have written on your topic. A literature review surveys scholarly articles, books and other sources (e.g. dissertations, conference proceedings) relevant to a particular issue, area of research, or theory, providing a description, summary, and critical evaluation of each work. The purpose is to offer an overview of significant literature published on a topic.
• Problem formulation – which topic or field is being examined and what are its component issues?
• Provenance – What are the author's credentials? Are the author's arguments supported by evidence (e.g. primary historical material, case studies, narratives, statistics, recent scientific findings)?
• Objectivity – Is the author's perspective even-handed or prejudicial? Is contrary data considered or is certain pertinent information ignored to prove the author's point?
• Persuasiveness – Which of the author's theses are most/least convincing?
• Value – Are the author's arguments and conclusions convincing? Does the work ultimately contribute in any significant way to an understanding of the subject?
Critical appraisal is the process of carefully and systematically examining research to judge its trustworthiness, and its value and relevance in a particular context.
Frequently there will have been more than one study addressing a particular health question. In such circumstances it is logical to collect all these studies together and base conclusions on the cumulated results. However the same scientific principles as would be expected in the original studies need to be applied to the identification, sorting and analysis of potentially relevant studies. This is what is meant by a systematic review. The most obvious sign that a review is systematic will be the presence of a methods section. Meta-analysis is the statistical process of combining the results from several studies that is often part of a systematic review.
What is a Randomised Controlled Trial (RCT)?
An RCT is a type of interventional or experimental study design. Participants (individuals or groups) are randomly allocated to receive either the new intervention being tested or a control treatment (usually the standard treatment or a placebo). Each arm of the study is then followed up and the amount or severity of the disease measured in the intervention group and compared with the control group. RCTs are by definition prospective.
What is a Qualitative study?
A qualitative study examines the experiences and beliefs of people from their own perspective. It can take many forms including in-depth interviews and focus-groups with analysis attempting to identify underlying themes. Verbatim quotes of participants can be used to illustrate these themes.
What is a Cohort study?
A cohort study, also known as a follow-up or longitudinal study, is another observational study design. In this study a population who do not have the health outcome or disease of interest are first divided into those who are exposed to a risk factor and those who are not. Alternatively exposed and unexposed populations may be chosen separately. Irrespective, both groups are then followed, often over long periods of time. At the end of the period of observation the incidence of disease or frequency of health outcome in the exposed group is compared to that in the unexposed group. The study is generally prospective as it looks forward from potential cause to consequence.
What is a Case-Control study?
A case-control study belongs to the observational group of studies. It begins by choosing individuals who have a health outcome or disease whose cause you want to investigate. These are the cases. Controls without the health outcome are then chosen. You then determine the proportion of cases who were exposed to any risk factor of interest in the past, and compare this with the proportion exposed in the control group. The study is generally retrospective because it looks backwards in time to the earlier exposures of individuals.
Public Health eLearning Toolkit (PHeLT)!
PHeLT brings together specially selected, quality approved resources to help you improve your skills in critical appraisal, understanding copyright, and ethical use of information. PHeLT also includes a self-test element that allows you to identify particular areas to focus on when improving your skills.
Few information sources will meet every criterion in the list, and even those that do may not possess the highest level of quality possible. But if you learn to use the criteria in this list, you will be much more likely to separate the high quality information from the poor quality information.
• Credibility trustworthy source, author's credentials, evidence of quality control, known or respected authority, organizational support.
• Accuracy up to date, factual, detailed, exact, comprehensive, audience and purpose reflect intentions of completeness and accuracy.
• Reasonableness fair, balanced, objective, reasoned, no conflict of interest, absence of fallacies or slanted tone.
• Support listed sources, contact information, available corroboration, claims supported, documentation supplied.


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Home Network Marketing Network Marketing Tips
How brands are celebrating NAIDOC week 2021
NAIDOC Week is currently running (4 – 11th of July) with a theme of 'Heal Country!' – it is an opportunity to celebrate the history, culture and achievements of Aboriginal and Torres Strait Islander peoples. It is also a chance for the whole community to listen, learn and support Indigenous peoples and ventures.
From a business perspective, the National NAIDOC Committee is actively championing Aboriginal and Torres Strait Islander businesses to bring the week to life, partnering with a wide variety of companies.
This year Marketing takes a look at what brands and businesses are doing in Australia to recognise NAIDOC Week.
Facebook Australia and Campfire x
Facebook Australia has partnered with Indigenous Australian led creative consultancy Campfire x to share a discovery initiative called 'Connect To Country'. he Connect to Country Facebook page has a range of storytelling resources, including videos to learn how to acknowledge Country and tips for connecting with their local community and language groups.
A pilot series of unique First Nations stories has also been launched. The series will be served to Facebook and Instagram users who live in corresponding areas, connecting them with the land they're on.
"There are so many positive stories in our Aboriginal and Torres Strait Islander communities that need to be shared, and stories told by our own people," says the co-founder of Campfire x Brad Cooke.
Image: Wayne Quilliam
Australia Post
Australia Post recently updated its addressing guidelines to include Traditional Place names and Acknowledgement of Country. This idea was started in the community by Gomeroi woman Rachael McPhail. It encourages people to recognise and consider the history and the connection of First People to country.
In addition, it has shared a video on social media of Kaurna and Narungga artist and Australia Post employee Richard Brown, explaining what inclusion means for his community.
Woolworths Group has partnered with the National NAIDOC Committee to distribute the 2021 NAIDOC Week poster to Woolworths supermarkets and Metro stores nationally, to help communities across the country celebrate. Around 200,000 NAIDOC posters will be shared to 1000 Woolworths outlets across the country. This year's poster features the work of Gubbi Gubbi artist Maggie Jean-Douglas, titled 'Care for Country'.
Network 10 has a range of programming around NAIDOC week like most broadcasters, but also made a simple but effective change to its regular schedule. The weather was presented a little differently on the 4th of July to kick-off the beginning of NAIDOC week and people took to social media to share their approval. Weather presenter Amanda Jason used the traditional Aboriginal names for cities, rather than colonial names when presenting the forecast.
Bravo @10NewsFirst for the #NaidocWeek weather forecast 👏👏#NAIDOCWeek2021 pic.twitter.com/zBSRfGSsC4
— Mich-Elle Myers (@MichMyersMUA) July 4, 2021
Tourism Australia has launched a 'Welcome To My Country' video, featuring prominent Aboriginal Elders. The messaging promotes tourism experiences that connect travellers with the Traditional Custodians. Consumers are encouraged to connect with over 185 Aboriginal guided tourism offerings promoted by the 'Discover Aboriginal Experiences' marketing collective.
In addition to the campaign, Tourism Australia has shared its fourth Reconciliation Action Plan. The action plan includes strategic priorities and framework for Tourism Australia to follow to better partner with Aboriginal and Torres Strait Islander peoples and businesses to achieve its goals. The plan includes a message from the CEO of Reconciliation Australia, Karen Mundine.
The national broadcaster is elevating Indigenous voices to promote NAIDOC week. It has created a promotional campaign running for the entire week, featuring Aboriginal and Torres Strait Islander journalists and presenters from the ABC. The staff share their personal experiences, acknowledging the importance of Indigenous storytelling all-year round.
Pinterest is highlighting its NAIDOC Week Shop in Australia, with several indigenous owned businesses featuring to make it easier for Pinterest users to discover and shop their products. The shop will run throughout the month of July for maximum exposure. From a content perspective, Pinterest is also promoting Indigenous creators, featuring their 'Idea Pins' across popular categories like cooking, beauty, food or fashion.
According to Pinterest, searches for NAIDOC Week Activities have increased by 80 percent , while searches for Indigenous activities for kids have increased by 25 times. Additionally, users are looking to glean inspiration from Indigenous artists, with searches for Aboriginal Art tripling.
The 2021 National NAIDOC Poster, 'Care for Country' is designed by Gubbi Gubbi artist Maggie-Jean Douglas.
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redpajama_set_name: RedPajamaCommonCrawl


text:
Canal+ 2, anteriorment conegut com a Canal+ Dos, foguèt un canal de televisió privat espanyol, de pagament, de l'empresa Sogecable. Aquest canal generalista i d'entreteniment emet cinema familiar durant tota la setmana, sèries, documentals i diversos continguts de Canal+, a excepció dels esportius.

Canal+ Dos emet a través de la plataforma Digital+, tant a través d'Astra como d'Hispasat. També emet a través de la plataforma TDT Premium.

Història
El 31 d'agost del 1997, amb l'arribada de Canal Satélite Digital, la primera plataforma digital de Sogecable, es crearen dues versions de Canal+ amb diferents horaris de programació per a conformar el paquet premium de l'operador. Aquests canals van rebre els noms de Canal+ Azul i Canal+ Rojo.

Més tard, amb el naixement de Digital+ a causa de la fusió de Canal Satélite Digital i Vía Digital, Sogecable reformà els seus canals. Entre els afectats van estar Canal+ Rojo i Canal+ Azul que, units, passaren a ser Canal+ 2 el 21 de juliol del 2003. A més es crearen canals temàtics de cinema i esports.

Canal+ 2 va néixer per donar un nou horari als continguts de Canal+, a més de servir com a finestra cinematogràfica per quan Canal+ emetia un altre tipus de continguts.

Durant la setmana del 19 de juliol al 25 de juliol del 2010, Engel, empresa distribuïdora de productes d'electrònica, anuncià a la seva pàgina web que per al 16 d'agost es podrien reservar les unitats limitades dels productes que comercialitzaria Sogecable per a la TDT de pagament amb el nom de Canal+ Dos. Després de la filtració de la notícia en diversos fòrums, es van estendre els rumors d'un nou canal d'entreteniment en la modalitat de pagament per a la TDT sota el segell de Canal+, ja que al gener del 2010 s'anuncià que 40 Latino cessaria les seves emissions en obert per al 23 d'agost del 2010.

Finalment, una setmana abans del llançament com ja anuncià Engel, Sogecable confirmà en una nota de premsa que, després de moltes especulacions, Canal+ 2 es transformaria en Canal+ Dos per donar el pas a la TDT amb nous i diversos continguts.

Canal+ Dos començà les seves emissions el 23 d'agost del 2010 en substitució de 40 Latino. Aquest canal va néixer de la mà de Sogecable en obtindre tres espais al múltiplex de Gestevisión Telecinco per emetre a través de la televisió digital terrestre d'àmbit nacional. Aquest fet es va produir després de la fusió entre Telecinco y Cuatro. Dels tres espais cedits a Sogecable, un és gestionat completament per emissió en obert, el qual està ocupat per CNN+. Els dos espais restants són gestionats per emissions de pagament, a través d'un dels quals emet Canal+ Dos. El canal que emetrà en l'altre espai no ha sigut determinat encara.

Inicialment feren una oferta de llançament en la que, per als abonats a la TDT Premium, van emetre els dos primers mesos gratis. Actualment la quota és de 15€/mes amb permanència de 12 mesos sense penalització.

Actualment, a més de les redifusions de Canal+, té programació pròpia, i serveix com una nova finestra, com passava amb la UEFA Champions League, per als continguts de Sogecable i per a programes o sèries que no tenen espai en Canal+. També inclou petits blocs de programació de Canal+ Xtra.

Referències

Vegeu també
 Sogecable
 Digital+
 Canal+
 CNN+
 Telecinco
 Cuatro
 LaSiete
 FactoríaDeFicción
 Boing
 Cincoshop

Enllaços externs
 Digital+
 Canal+ Dos

Sogecable
Canals de Mediaset Espanya

redpajama_set_name: RedPajamaWikipedia


Multiple codes will not be accepted in the same transaction, Walk In Style reserve the right cancel or change this promotion at any time. Codes must be entered at the checkout and can not be claimed after the transaction is complete. Codes will only be accepted on full priced products only.
This promotion ends on Tuesday 23rd April 2019.
They will have access to the personal information needed to allow them to perform their function but may not use it for any other purpose.
We only use secure payment gateways to process payments. Your credit card details are not stored on our database. We take all possible care to protect your personal details but in the absence of negligence on our part we can not be held liable for any loss you may suffer if a third party procures unauthorised access to the data provided when you placed your order.
You may not use this site or any of its content to further any commercial purpose, including any advertising or advertising revenue generation on your own site. You use this site at your sole risk. We reserve the right to deny you access to this site, or any part of it, at any time without notice. If you engage in prohibited activities you could be denied access to the Site on a permanent basis.
All payments will be made in sterling. Customers outside the UK will be responsible for any additional delivery charges and duty/import charges which may be applicable.
Please note that Walk in Style reserve the right not to accept your order in the event, for example, that we are unable to obtain authorisation for payment, if the item ordered is out of stock or if the item has been withdrawn from sale due to quality control reasons.
If you are not completely satisfied with your purchase, you can return your unworn and unused goods to us at any time within 7 days of receipt. We are happy to offer a full refund on the cost of the goods or an exchange. The customer must bear the cost of the return postage. See Full Terms.


text:
Q: Sync All Post Type Tag I have a few post types in my website. Is it possible that all post type using the same post tag?
For example:
PostType A have a "Apple" tag.
PostType B, PostType C, PostType D use PostType A "Apple" tag
If this is not possible,I have another question: it possible to sync all post types' tag?
For example:
I create a new "ABC" tag in PostTypeA and PostTypeB will automatically has "ABC" tag.

A: If you want to auto-create the same term in another taxonomy, the following code should do it:
You'll add the code to the theme functions file (i.e. functions.php), and make sure to change the $taxonomies which is the list of the applicable taxonomy slugs — the taxonomies that you wish to "sync". Both the $taxonomies should have the exact same values.
But note that this code is intended for terms that do not have parents; or rather, non-hierarchical taxonomies.
$taxonomies = ['my_tax', 'post_tag'];
foreach ( $taxonomies as $taxonomy ) {
    add_action( 'created_' . $taxonomy, 'auto_create_term' );
}

function auto_create_term( $term_id ) {
    $term = get_term( $term_id );
    if ( ! $term || is_wp_error( $term ) ) {
        return false;
    }

    $taxonomies = ['my_tax', 'post_tag'];
    foreach ( $taxonomies as $taxonomy ) {
        if ( $taxonomy !== $term->taxonomy ) {
            remove_action( 'created_' . $taxonomy, __FUNCTION__ );

            wp_insert_term( $term->name, $taxonomy, array(
                'description' => $term->description,
                'alias_of'    => $term->slug,
            ) );

            add_action( 'created_' . $taxonomy, __FUNCTION__ );
        }
    }
}

What the code is doing: We're using the created_{taxonomy} action to auto-clone a term; but we temporarily remove the hook while we're cloning the term — and then add the hook back after the term is cloned (created in the target taxonomy).

redpajama_set_name: RedPajamaStackExchange


text:
PATENT DAILY (Pharma)
Some Interesting Patent CI News Updates
Compulsory License India
Indian Patent Act brief
Indian Pharma Patent Cases
Tag Archives: Schering
CRCT & Schering has sued Accord Healthcare Temodar
Posted on 24/11/2010	by Guna
Cancer Research Technology Limited & Schering has sued Accord Healthcare on US Patent 5260291. Product: Temodar Capsule (Temozolomide). Note: Teva is the first to file ANDA holder. In the Paragraph litigation district court had held '291 patent invalid due to … Continue reading →
Posted in Patent case	| Tagged Accord, Schering, Temodar, Temozalomide	| Leave a comment
Patent Daily RSS
Twitter Guna
Happy #gobackmodi day 12 months ago
RT @nikhilkarani1: Aurobindo acquires oral solid & derm Biz of Sandoz - Acqd Biz has sales worth $1.2bn & Aurobindo wud pay $900mn in cash… 1 year ago
RT @ainvvy: 0. On Independence day, I look briefly at how some of the current states came into being. Some of them I had not even heard be… 1 year ago
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RT @VikasDandekarET: #Cipla bets on speciality #pharma business in US; aims for commercial launches by 2020 economictimes.indiatimes.com/industry/healt… 3 years ago
RT @scarthik: @itisprashanth வாழ்வில் நமதுதேவை குறித்த தெளிவான தேர்வும், அதைநோக்கிய நேர்மையான தேடலும்இருந்துவிட்டால், வெற்றி கூடிவரும். அமை… 3 years ago
IPR & CI News (Pharma)
New Drug Approvals – US FDA
FDA Approves Tepezza (teprotumumab-trbw) for the Treatment of Thyroid Eye Disease (TED) 21/01/2020
DUBLIN--(BUSINESS WIRE)--Jan. 21, 2020-- Horizon Therapeutics plc (Nasdaq: HZNP) today announced that the U.S. Food and Drug Administration (FDA) has approved Tepezza (teprotumumab-trbw) for the treatment of Thyroid Eye Disease (TED). Tepezza is the...
FDA Approves Ozempic (semaglutide) for Cardiovascular Risk Reduction in Adults with Type 2 Diabetes and Known Heart Disease 16/01/2020
PLAINSBORO, N.J., Jan. 16, 2020 /PRNewswire/ -- Novo Nordisk today announced that the U.S. Food and Drug Administration (FDA) has approved a new indication for Ozempic (semaglutide) injection 0.5 mg or 1 mg to reduce the risk of major adverse...
FDA Approves Numbrino (cocaine hydrochloride) Nasal Solution for Nasal Anesthesia 13/01/2020
PHILADELPHIA, Jan. 13, 2020 /PRNewswire/ -- Lannett Company, Inc. (NYSE: LCI) today announced that the U.S. Food and Drug Administration (FDA) has approved the New Drug Application (NDA), submitted under the 505(b)(2) regulatory...
FDA Approves Valtoco (diazepam nasal spray) as a Seizure Rescue Treatment 13/01/2020
SAN DIEGO, CA – January 13, 2020 – Neurelis, Inc., today announced that the U.S. Food and Drug Administration (FDA) has approved Valtoco (diazepam nasal spray) as an acute treatment of intermittent, stereotypic episodes of frequent...
FDA Approves Ayvakit (avapritinib) for the Treatment of Adults with Unresectable or Metastatic PDGFRA Exon 18 Mutant Gastrointestinal Stromal Tumor 09/01/2020
CAMBRIDGE, Mass., Jan. 9, 2020 /PRNewswire/ -- Blueprint Medicines Corporation (NASDAQ: BPMC), a precision therapy company focused on genomically defined cancers, rare diseases and cancer immunotherapy, today announced that the U.S. Food and Drug...
FDA Approves Expanded Indication of Mycamine (micafungin for injection) for the Treatment of Invasive Candidiasis in Pediatric Patients Less Than 4 Months of Age 08/01/2020
NORTHBROOK, Ill., Jan. 8, 2020 /PRNewswire/ -- Astellas Pharma Inc. today announced that the U.S. Food and Drug Administration (FDA) has approved its supplemental New Drug Application (sNDA) for Mycamine (micafungin for injection) in support of the...
FDA Approves Keytruda (pembrolizumab) for Patients With BCG-Unresponsive, High-Risk, Non-Muscle Invasive Bladder Cancer 08/01/2020
KENILWORTH, N.J.--(BUSINESS WIRE) January 8, 2020 --Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved Keytruda, Merck's anti-PD-1 therapy, as...
FDA Approves Fiasp (insulin aspart injection) for the Treatment of Children with Diabetes 06/01/2020
PLAINSBORO, N.J., Jan. 6, 2020 /PRNewswire/ -- Novo Nordisk today announced that the U.S. Food and Drug Administration (FDA) has approved Fiasp (insulin aspart injection) 100 u/mL for use as a new mealtime insulin option for children with diabetes.1...
Lynparza (olaparib) Approved in the US as a First-Line Maintenance Treatment of Germline BRCA-Mutated Metastatic Pancreatic Cancer 30/12/2019
30 December 2019 -- AstraZeneca and Merck & Co., Inc., Kenilworth, N.J., US (Merck: known as MSD outside the US and Canada) today announced that Lynparza® (olaparib) has been approved in the US for the maintenance treatment of adult patients...
FDA Approves Dayvigo (lemborexant) for the Treatment of Insomnia in Adult Patients 23/12/2019
December 23, 2019 -- Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, "Eisai") today announced that the U.S. Food and Drug Administration (FDA) approved the new drug application for its in-house discovered and developed orexin...
New Drug Applications – US FDA
Nektar Issues Statement Regarding FDA Advisory Committee Vote for Oxycodegol
SAN FRANCISCO, Jan. 14, 2020 /PRNewswire/ -- Nektar Therapeutics (NASDAQ: NKTR) issued a statement today following a meeting of the Food and Drug Administration's (FDA's) Anesthetic and Analgesic Drug Products...
Chiasma Announces FDA Acceptance of Mycapssa New Drug Application Resubmission
NEEDHAM, Mass., Jan. 13, 2020 (GLOBE NEWSWIRE) -- Chiasma, Inc. (NASDAQ: CHMA), a clinical-stage biopharmaceutical company focused on improving the lives of patients with rare and serious chronic diseases, today announced that the U.S. Food and Drug...
Alnylam Initiates Rolling Submission of New Drug Application (NDA) to U.S. Food and Drug Administration (FDA) for Lumasiran for the Treatment of Primary Hyperoxaluria Type 1 (PH1)
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jan. 10, 2020-- Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, announced today that the Company has initiated a rolling submission of its New Drug Application (NDA)...
Nabriva Therapeutics Receives FDA Acknowledgement of New Drug Application Resubmission for Intravenous Contepo (fosfomycin) for Injection
DUBLIN, Ireland, Jan. 08, 2020 (GLOBE NEWSWIRE) -- Nabriva Therapeutics plc (NASDAQ: NBRV), a commercial-stage biopharmaceutical company engaged in the development of innovative anti-infective agents to treat serious infections, announced that the...
Urovant Sciences Announces Submission of New Drug Application for Vibegron for the Treatment of Overactive Bladder
IRVINE, Calif. & BASEL, Switzerland--(BUSINESS WIRE)--Dec. 30, 2019-- Urovant Sciences (Nasdaq: UROV) announced today that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug...
Immunomedics Announces FDA Acceptance for Filing of Biologics License Application Resubmission for Sacituzumab Govitecan to Treat Metastatic Triple-Negative Breast Cancer
Morris Plains, N.J., Dec. 26, 2019 — Immunomedics, Inc. (NASDAQ: IMMU) ("Immunomedics" or the "Company"), a leading biopharmaceutical company in the area of antibody-drug conjugates, today announced...
Correvio Receives Complete Response Letter From U.S. FDA for Brinavess and Provides Update on Recent Events
VANCOUVER, Dec. 24, 2019 /PRNewswire/ - Correvio Pharma Corp. (NASDAQ: CORV) (TSX: CORV), a specialty pharmaceutical company focused on commercializing hospital drugs, today announced it has received a Complete Response Letter...
Zosano Announces FDA Submission of New Drug Application for Qtrypta
FREMONT, Calif., Dec. 23, 2019 (GLOBE NEWSWIRE) -- Zosano Pharma Corporation (Nasdaq:ZSAN), a clinical-stage biopharmaceutical company, today announced the submission of a 505(b)(2) New Drug Application ("NDA") for...
FibroGen Submits New Drug Application to the U.S. FDA for Roxadustat in Patients With Anemia of Chronic Kidney Disease
SAN FRANCISCO, Dec. 23, 2019 (GLOBE NEWSWIRE) -- FibroGen, Inc. (NASDAQ:FGEN), today announced the submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for roxadustat for the...
BioMarin Submits Biologics License Application to U.S. Food and Drug Administration for Valoctocogene Roxaparvovec to Treat Hemophilia A
SAN RAFAEL, Calif., Dec. 23, 2019 /PRNewswire/ -- BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) announced today that the company submitted a Biologics License Application (BLA) to the U.S. Food and Drug Administration (FDA) for its...


"I can't authorise your unemployment claim." The waters have come up to my neck.
Seek God in the midst of the difficulties of unemployment.
God's faithfulness underlies human productivity, but people have to do the actual work.


In the heart of California's Santa Ynez Valley, Rancho Sanja Cota is an extraordinary historic ranch with an unparalleled assemblage of 8 certified parcels for a total of approximately 1227.34 acres. Situated south of Santa Ynez in Santa Barbara County, the ranch is comprised of rolling hills, woodlands, foothills and mountain areas, all with breathtaking scenery. The ranch is bordered by the Santa Ynez airport to the north and the Santa Ynez River to the South, which together afford the ranch unique amenities of accessibility and abundant water.
The beauty of the ranch is only surpassed by its natural endowments including rich soil, crystal-clear night sky and diverse wildlife. Approximately 600 acres are planted and approx. 1,020 acres are plant-able making it ideal for agricultural or equestrian pursuits. The ranch includes various residences and additional improvements, including ag buildings and farm structures exist near the southerly portion of the ranch, including a shop, office, equipment storage, three warehouses, two grain tanks, and two pole barns. Abundant water is supplied from the Santa Ynez River Basin, an intersecting creek, and six wells.
Ranches of this size, caliber and proximity to the charming wine communities of Santa Ynez and Los Olivos rarely are offered for sale. Rancho Sanja Cota presents an opportunity to acquire a trophy ranch truly like no other.
Rancho Sanja Cota consists of 8 certified parcels for a total of approximately 1227.34± acres zoned Agriculture.
Approximately 600± acres are planted and approximately 1,020± acres are plantable.
Most of the ranch is zoned AG-II-100, with four parcels totaling 9± acres located at the north end zoned AG-I-5.
Rancho Sanja Cota is under a Williamson Act Contract, a California law that provides relief of property tax to owners of farmland in exchange for a 10-year agreement that the land will not be developed.
Property taxes for the 2015/2016 tax year were $37,367.
Abundant water is supplied from the Santa Ynez River Basin that follows the southern border, an intersecting creek, and 6 wells.
Located on the property is employee housing, ag buildings and farm structures exist near the southerly portion of the ranch, including a shop, office, equipment storage, three warehouses, two grain tanks, and two pole barns.
The property is fenced and cross-fenced with graded gravel and dirt roads for accessing crop and grazing locations.
The ranch is served by public telephone and electricity and a private septic system. The residential units are serviced by propane.


Preheat oven to 400 degrees. Microwave milk on HIGH for 1 1/2 minutes. Melt 2 tbsp. butter in a large skillet or Dutch oven over medium-low heat. Whisk in flour until smooth. Cook, whisking constantly, 1 minute. Gradually whisk in warm milk and cook, whisking constantly, 5 minutes or until thickened.
Whisk in salt, black pepper, 1 cup cheddar cheese, Romano cheese and Parmesan cheese, and if desired, red pepper. Whisk until smooth. Stir in cooked pasta.
Melt remaining 4 tbsp. butter and mix with breadcrumbs and remaining cheddar cheese. Spoon pasta mixture into a lightly greased 2-quart baking dish; top with breadcrumb-and-cheese mixture. Bake for 20 minutes or until golden and bubbly.


text:
Cope Property Valuation, Cope Online Property Valuation, Cope Instant Appraisal
COPE 2852 NSW
Cope is approximately 76.47 square kilometres. In 2016 the population of Cope was 128. The population is 53% male and 47% female. On average the monthly mortgage repayments in Cope are $1400 to $1799. The most common weekly income bracket is $400 to $499 per week. Weekly rents in the area are on average $0 to $74.
Cope (Mid-Western Regional) is located in the Central West region, New South Wales (NSW) in Australia. The satellite coordinates of Cope are: latitude 32°16'52"S and longitude 149°40'5"E. Cope, 2852 is 229 kms NW of Sydney and 36 kms North of Mudgee.
Balickera Property Valuation
Lake Heights Property Valuation
Mount Buller Property Valuation
Netherby Property Valuation
Girards Hill Property Valuation
Eden Hill Property Valuation
Calarie Property Valuation
Fern Tree Property Valuation
Bucasia Property Valuation
Woody Head Property Valuation
Cooladdi Property Valuation
Coolgardie Property Valuation


text:
Q: PlayStation store error? On the ps3 when I go to install a game I already bought it just tells me a error code and I don't get to install my game and now I'm sitting here looking stuff up but I'm not finding a good answer to how I could fix this if someone has a answer that would really help.   (The error code is 80029509)

A: Unfortunately, it appears there is little you can do about this issue, as it isn't an issue with your console. It is being caused because thousands of PS3 players are panicking and rushing to download their games, causing a massive amount of traffic to be pushed through, which the server has some trouble with. According to Push,

It [the errors] could be a case that PS3's servers are simply experiencing
unprecedented traffic right now; Sony may have scaled down support for
the system over the years, but now there's been a sudden surge in
activity it's struggling to cope.

You could try setting an alarm to very early in your current time zone, as less people are likely to be online, but this only has a slight chance of working.


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text:
AAV-CRISPR mediated gene editing corrects Duchene Muscular Dystrophy phenotype
Gene editing is a genome engineering technology that allows us to make intended changes in the DNA. It includes ablating the target genes, inserting/deleting a segment of DNA to target site etc. CRISPR is a bacterial-derived gene editing technology consisting of cas9 protein and guide RNA. The CRISPR technology is being explored for the curative intervention of genetic diseases including muscular dystrophy.
The recent study by Gersbach lab published, in Nature Medicine, evaluated the long term efficacy of AAV mediated CRISPR delivery in the treatment of Duchene muscular dystrophy. In this study, the authors reported a corroborating data on the risk associated with AAV-CRISPR, novel approach to evaluate these risks and interesting results that pave the path for future research. In this study, the long term and persistent expression of Cas9/gRNA are observed in the mouse model of DMD (mdx null mice). The correction of dmd gene resulted in expression of the full-length dystrophin protein and minor quantities of other smaller isoforms. It also showed improved muscle health including decreased creatine kinase activity, neutrophil infiltration, cytokines, and inflammation.
While CRISPR based gene editing has shown promising results, the studies to unravel and characterize its associated risks are necessary to ensure safety and effectiveness in clinical studies. The CRISPR associated risks include:
a) Off-target effect
b) Genotoxicity
c)Immunogenicity and host defense
d) Promoter silencing and suppression of gene expression
First, the authors evaluated various route of administration of AAV serotypes, viral distribution, expression of CRISPR (Cas9 and guide RNA), and correction of the gene with an expression of functional dmd genes. The systemic administration showed an increase in expression of Cas9/ guide RNA in different tissues over time. In contrast, the intramuscular injection showed a significant decrease in the expression of this transgene overtime. The biodistribution studies showed the presence of the viral genome and Cas9/gRNA expression in skeletal muscles, cardiac muscles, liver, and other tissues. These non-selective tissue expression of the transgene is dependent on: i) tropism of the AAV8 and ii) the CMV promoter. The characterization of gene editing in unintended tissues and decreasing its occurrences are crucial for advancing CRISPR to clinical phase.
Next, this study also examined the different gene editing events after administration of AAV8-CRISPR in the mice model. The unintended insertions and deletions at the target site, off-target indels, and AAV viral genome integrations were characterized. The targeted ddPCR or PCR/deep sequencing method is generally used for monitoring insertion/deletion or integrations. This method is not suitable for large insertion or deletions that alter the primer sites. Therefore, the authors performed unbiased gene sequencing using Illumina's Nextra-transposon based library preparation for sequencing and characterized the genome modification after administration of AVV8 CRISPR. A small number of indels at the target site and off-target viral integrations were detected in host tissues. More importantly, approximately 7% of the indels were detected in the exonic sites of the genome. Mostly, the genetically engineered AAVs do not integrate into the host tissues. But CRISPR mediated double-strand DNA break (DSB) and induction of DSB repair increases the probability of viral genome integration. Although, these integrations are not seen on the oncogenic sites, or protein-coding regions, the genotoxicity characterization is imperative for the safety.
Finally, Nelson et al. 2019 evaluated the incidence of immunogenicity but lacked the evidence to sufficiently show an impact on gene editing and correction. The study showed a higher incidence of anti-Cas9 antibodies and T-cell response (measured using ELISPOT). But the expression of Cas9/gRNA seemed unaffected up to six months to one year of administration. When the AAV-CRISPR was administered intraperitoneally to the neonates, the immune response was not observed in these mice. This provides evidence that neonatal tolerization against AAV-CRISPR may help mitigate the immunogenicity related safety risk.
In conclusion, this study provided the persistent Cas9/gRNA expression, gene correction, dystrophin expression in muscle and improved muscular heath after administration of AVV-CRISPR gene editing in DMD mouse model. This study also provided novel methods to interrogate the safety risk and provide substantial evidence on the safety issues associated with CRISPR gene editing technology.
-Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy
-Gersbach Lab


text:
So essentially, the enemy of my enemy is not my friend, he's just another moronic, entitled turd in the bucket.
Messages - babyjesus
Pages: [1] 2 3 4 5
Apple Talk / Re: AN ERA ENDS. CAPITOL GRILLING FINALLY CROAKS.
Quote from: The Good Reverend Roger on December 17, 2012, 03:41:52 pm
Capitol Grilling is no more. It's still up, but posting is disabled, and won't be reenabled before the site expires.
It turns out that Zeroflux at some point went from a libertarian/independent (and meant it, too, I've known him for 10 years) to a teabagger. He called the election in Virginia wrong, and got pissed. Then there was a gun control thread about the recent massacre, and he spazzed out, called everyone "morons", and then announced he was shutting the board down, presumably because there aren't any teabaggers left.
In its heyday (2000-2006), it was the best political board ever. It declined from 2006-2008, as Zero took less and less interest in moderating it. It's been on life support ever since, and it's probably a good thing that it was allowed to finally die.
So long, Zero. You were a titan among men, but in the end you were just another putz.
Well I went looking for Capitol Grilling a few weeks ago and it was gone, no archives, nada, not even a mention in a Google search. But I did find this thread and lo and behold the OP is an old poster from CG named Malaclypse or Doc Howl. Always assumed they were one in the same but wasn't certain.
These twins had a completely different personality in that other place and time. Bearing only a slight resemblance to their apparitions on this forum.
Back then if Mal wasn't a screetching partisan you would never have guessed it, he seemed to be so much part of team librul. Even wore the cap and cleated shoes into the bar thread. He didn't wax poetic like he does in his rants here. He didn't polish his sentences and bother with grammar and/or spelling or even give a rat's ass whether he was skillfully reaching his audience, or just alienating them.
Course I was a real dickface in that forum myself. Never was a partisan but I couldn't help but kick them at every opportunity. I was mostly there to study the phenom or partisanship and find out whether it could be cured.
I know how to challenge cognitive dissonance and once you crack that shell a person's own feelings alert them to the fact that they are full of shit.
You can lead a partisan to water but you can't make him/her think.
So here is an other Mal. One who doesn't have that much in common with his alter at CG. One who rants like his intended audience is gonna pick his speel up off the city pavement beneath a tall downtown office building manana and read it, toss it or step on it, almost by random selection.
It is what it is. You never really know anybody, not even yourself. We all change. We aren't a static incarnation of ourselves. We are dynamic and part of a dynamic reality.
Aside from Mal the welcome wagon on this forum has the charisma and warmth of a tribe of cannibals. I have no interest in dialogue with shit flinging adolescent howler monkeys. Life's short, no time, sorry.
But I think I read all of your rants, Mal. Except those that were blarged out of existence. And I hear and approve of your underlying emphasis on our freedom to choose. You come back to that theme in almost every rant. I hear ya.
Thanks Mal. You be well.
To each and every one of you, I hope your path leads you where you choose to go.
And that's my cue.
And btw, loved the family pics, but for the purpose of this conversation dinos are just cold blooded birds.
Aneristic Illusions / Re: Hillary's Closest Aide Admits Clinton 'Illegally' Burned Daily Schedule
A majority of Americans disapprove of FBI director James Comey's recommendation that Clinton not be charged with a crime over her email arrangement, by 56-35.
Nearly nine in 10 Republicans disagree with the FBI's decision and say it worries them about what she'd do if she became president.
Democrats see things very differently, but with less unanimity –- about two-thirds approve of the decision not to charge Clinton and think the issue is unrelated to what she'd do as president. But three in 10 of Clinton's own party faithful think she should have been charged.
Further, as noted, political independents side more with Republicans on the issue, with roughly six in 10 saying the FBI was wrong and that the issue raises worries about Clinton as president.
http://www.zerohedge.com/news/2016-07-11/majority-americans-disapprove-comeys-decision-hillary
nearly a third of her own party faithful thinks that Pres elect Clinton should be charged with a crime.........
Nothing to see here, move along
Aneristic Illusions / Re: UNLIMITED ZEROHEDGE APPRECIATION THREAD!
Two Houston Police Officers Kill Gunman Who Aimed At Cops While Obama Tries To Talk Down Social Divide
According to ACB13, two Houston officers shot and killed an armed man on the city's south side early this morning. Police says the officers involved were wearing body cameras and they each fired multiple shots.
Houston Police Department officials say the shooting happened on Cullen near Ward around 12:40am. Officers say they saw a man with a revolver standing in the road. There were two officers in one vehicle and they asked the man to put the revolver down. Police say a witness also asked him to drop the weapon. Officers say instead of dropping the gun, the man raised his weapon pointing it in the air. He then lowered it and pointed it at the two officers.
http://www.zerohedge.com/news/2016-07-09/latest-shooting-two-houston-police-officers-kill-gunman-who-aimed-gun-cops
to put this in perspective: "We are all Palestinians now", or if you prefer "first they came droning Waziristanians and I said nothing because I wasn't Waziristani"
The ghost of John Belushi is not amused!
Quote from: P3nT4gR4m on July 09, 2016, 06:20:51 pm
Is my point. Security is a degree of scale. There is no absolute. Which kinda fucks with his Liberty for Security theory. Liberty for security may well be the pitch that government inc are making and sure as fuck they'll take their payment in advance but that doesn't make it any less bullshit. I'm with ECH - I got plenty of both, go sell snake oil somewhere else.
actually the fact that there is no absolute security only strengthens my point. But as you progress up any scale of security from 0 to infinity you likewise lose liberty en route.
Techmology and Scientism / Re: AIisboredwithyoureconomyalready/helicopter money, wtfn?
cars don't kill people, self driving cars kill people.
DETROIT — The race by automakers and technology firms to develop self-driving cars has been fueled by the belief that computers can operate a vehicle more safely than human drivers.
But that view is now in question after the revelation on Thursday that the driver of a Tesla Model S electric sedan was killed in an accident when the car was in self-driving mode.
You gotta forgive the self driving AI for this one, it is still in the beta testing stage of development.
A friend of mine owns a tesla and when he bought it it didn't do self driving.
BUT it spontaneously downloaded the programming to become self driving one day, and so it was: a self driving car.
Hackable, as reliable as an auto part or any Windows program, and careening through every city in the US at 60 mph, built by a corporate code to maximize profits and externalize risks and costs. AND they are gonna do the same to buses and 18 wheelers! (don't play in traffic, kids!)
Sounds like a recipe for disaster just like it did in the late 90s when I heard the first mention of SDV R&D.
On the other hand we have been using the same basic technology to steer ships and airplanes for decades and in my experience they definitely outperform human error.
I feel statistically safer. You?
Meet the cute little drone that nuked the Dallas sniper:
http://www.zerohedge.com/news/2016-07-09/due-process-drone-was-used-blow-us-citizen-without-trial-week
I love the handle!
If I wonder about this extrajudicial assassination at all I wonder "why a bomb?"
Why not a smoke bomb or pepper spray, or even live wasps released onto the sniper?
I think the answer is pretty simple. DON"T KILL FUCKING COPS!
Cops in the US have always gone after cop killers intending to kill them, rather than take them alive. And they do it manhunt style with all the fixins.
They have to maintain a state monopoly on the use of force.
I fought the law, and the law won. Duh!
Quote from: East Coast Hustle on July 09, 2016, 03:40:42 pm
Quote from: AIbrdwthulrdy on July 09, 2016, 06:19:48 am
Quote from: East Coast Hustle on July 09, 2016, 04:15:23 am
Dude, stop spamming links to zerohedge. I can tell when someone's just trying to drive traffic to a site and I won't tolerate it. Consider this your one warning.
You can't have liberty and security, the two are mutually exclusive.
But you can have liberty and death at once, although only momentarily. Que Sera!
You're a bit dim, aren't you? The two are only mutually exclusive if you rely on someone else for your security.
any kind of real security demands that you forfeit some or all liberty.
Quote from: Pergamos on July 09, 2016, 12:02:07 am
OP seems to be advocating for a guaranteed basic income, which is, in my opinion, the only bandaid that can keep capitalism alive. I prefer seizing the means of production, but that would be much messier.
btw, are you hip to anarcho-syndicalism?
Anarcho-syndicalism proposes that labor must own the means of production via the simple arrangement that all corps must be 100% employee owned.
In capitalism capital owns TMoP.
In Commyism the state owns TMoP.
In anarcho-syndicalism Labor owns TMoP.
Noam Chomsky also digs this shit!
I dig a pony. You?
In a perfect world all MoP would be owned by everybody to offset taxation and finance the social safety net. But we don't live in a perfect world and we can't trust politicos to manage anything.
And MoP is an outdated concept. Today's economy is more about the means of banking, the means of insurance, the means of healthcare, you know all the service sector economy stuff that matters in the now.
I am not venturing down that path because I like that path.
But compared to our (insert the most outlandish series of adjectives you can imagine) economic disorder that actually seems like the most practical alternative.
When the entire world acts, walks and sounds like the bullshitiest equation imaginable, within that framework only a hard core and revolutionary bullshitier solution can save the day.
Or maybe I have huffed too, no waaaaaaay too, much glue.
Admiral Glueon
If Senseless Violence Continues, America Will Be A Total Police State In No Time
exactly, the Big Blue BlowBack.
While we don't know who the police murderers in Dallas were, or their motivations, we do know one thing. Their actions will unquestionably have several very counterproductive and dangerous outcomes.
1. Further divide the country in general.
2. Further the already wide distrust between the police and the general public.
3. Increase the likelihood of more violence, and the eventual imposition of a total police state in America.
Either the people who committed the murders had the above goals in mind, or they were just stupid, violent criminals who didn't have the meager sophistication necessary to understand the extremely negative implications of their actions.
or they were just pissed and voting with their long rifles.
http://www.zerohedge.com/news/2016-07-08/if-senseless-violence-continues-america-will-be-total-police-state-no-time
The unintended consequences of the emerging War on Cops will that the cops fight back and win. They always win, cuz the people are skeered. States exist because they monopolize the use of force. Force is their strong suit and those who oppose them will end up disarmed, crossing check points and subject to law enforcement running roughshod across the law with no restraint.
I tells ya this now: This upcoming election is gonna be a show for the ages!
Quote from: Cain on July 08, 2016, 06:50:09 pm
Quote from: AIbrdwthulrdy on July 08, 2016, 05:00:01 pm
http://www.snopes.com/hillary-clinton-disqualified/
I read the link, it cited partisan sources who definitely sound to have been A) answering different questions and B) ill informed.
so who you gonna believe? Snopes or Cornell University Law School and the US Federal legal code?
She only managed to escape prosecution because Comey couldn't equate "extreme carelessness" with "gross negligence". Which of course any jury would have been instructed to equate.
Nice job at completely failing to read the link or refute the points within.
4 Shot, 1 Killed After Black Gunman Fires At Passing Cars On Tennessee Highway, Targeting Police, Whites
Case in point, the latest incident in what increasinly more are calling an all out race war was reported moments ago by AP who said that 37-year-old Lakeem Keon Scott, who is black, opened fire indiscriminately at passing cars and police on a Tennessee highway. He later told investigators he was angry about police violence against African-Americans. One woman died and three others, including one police officer, were injured in the rampage.
http://www.zerohedge.com/news/2016-07-08/one-dead-after-black-gunman-shoots-passing-cars-tennessee-highway-targeting-police-w
That is 5 cops killed, 8 more injured along with several white civilians in one 24 hour period.
War on Cops is clearly on. Lets see whom if anybody can settle things down.
Do we have any respected leaders anymore?
]quote]Manhunt Underway In St. Louis Suburb After Police Officer Shot In The Neck - Live Feed[/quote]
http://www.zerohedge.com/news/2016-07-08/manhunt-underway-st-louis-suburb-after-police-officer-shot-neck
that didn't take long.......


text:
Q: django class view Overlapping I am not good at English.
Please understand me.
I'm creating a blog  in Django.
I am making it into class view, but I want to see a reple list and form in the post details view.
like this
enter image description here
POST detailview has already been implemented and I don't know how to add comments.
Should I be function view?
Give me some advice.
code
views.py
class BlogLV(LoginRequiredMixin,ListView):
model = Blog

def get_queryset(self):
    return Blog.objects.exclude(user=self.request.user)

class BlogCV(LoginRequiredMixin,CreateView): # blog_form.html
model = Blog
fields = ['name','description','image']
success_url = reverse_lazy('blog:index')

def form_valid(self, form): #오류
    form.instance.user = self.request.user #user 설정
    form.instance.slug = self.request.user
    return super(BlogCV,self).form_valid(form)

class BlogDV(LoginRequiredMixin,DetailView):
model = Blog

class PostCreateView(LoginRequiredMixin,CreateView):
model = Post
fields = ['title', 'content']
success_url = reverse_lazy('blog:index')
template_name = 'blog/post_form.html'

def get_context_data(self, **kwargs):
    context = super(PostCreateView, self).get_context_data(**kwargs)
    context['blog'] = Blog.objects.get(slug=self.kwargs['slug'])
    return context

def form_valid(self, form):
    form.instance.user = self.request.user
    form.instance.slug = self.request.user
    return super(PostCreateView, self).form_valid(form)

class PostDV(LoginRequiredMixin,DetailView):
model = Post
fields =['title','content']

def get_context_data(self, **kwargs):
    context = super(PostDV, self).get_context_data(**kwargs)
    context['blog'] = Blog.objects.get(slug=self.kwargs['slug'])
    return context

class PostLV(LoginRequiredMixin,ListView):
model = Post
paginate_by = 5

def get_context_data(self, *, object_list=None, **kwargs):
    context = super(PostLV,self).get_context_data(**kwargs)
    context['blog'] = Blog.objects.get(slug=self.kwargs['slug'])
    return context

def get_queryset(self):
    return Post.objects.filter(slug=self.kwargs['slug'])

class PostDeleteView(LoginRequiredMixin,DeleteView):
model = Post
success_url = reverse_lazy('blog:index')

def get_context_data(self, *, object_list=None, **kwargs):
    context = super(PostDeleteView,self).get_context_data(**kwargs)
    context['blog'] = Blog.objects.get(slug=self.kwargs['slug'])
    return context

class PostUV(LoginRequiredMixin,UpdateView):
model = Post
fields = ['title','content']
success_url = reverse_lazy('blog:index')

def get_context_data(self, *, object_list=None, **kwargs):
    context = super(PostUV,self).get_context_data(**kwargs)
    context['blog'] = Blog.objects.get(slug=self.kwargs['slug'])
    return context

urls.py
urlpatterns = [
url(r'^$',BlogLV.as_view(),name="index"),
url(r'^create/$',BlogCV.as_view(),name='blog_create'),
url(r'^(?P<slug>[-\w]+)/$',BlogDV.as_view(),name='blog_detail'),
url(r'^(?P<slug>[-\w]+)/post/create/$',PostCreateView.as_view(),name='post_create'),
url(r'^(?P<slug>[-\w]+)/post/$',PostLV.as_view(),name='post_list'),
url(r'^(?P<slug>[-\w]+)/post/(?P<pk>[0-9]+)/$', PostDV.as_view(), name='post_detail'),
url(r'^(?P<slug>[-\w]+)/update/(?P<pk>[0-9]+)/$', PostUV.as_view(), name='post_update'),
url(r'^(?P<slug>[-\w]+)/delete/(?P<pk>[0-9]+)/$', PostDeleteView.as_view(), name='post_delete'),

]
models.py
@python_2_unicode_compatible
class Blog(models.Model): # 유저 당 하나
name = models.CharField(max_length=20)
description = models.CharField(max_length=30)
image = models.ImageField(upload_to='blog/profile')
create_date = models.DateTimeField(auto_now_add=True)
slug = models.SlugField(unique=True,allow_unicode=True)
# 블로그 생성한 시각
# 저장 경로: MEDIA_ROOT/blog/projile/xxx.jpg 파일 저장
# DB 필드 'MEDIA_URL/blog/profile/xxx.jpg' 문자열 저장
user = models.OneToOneField(User)
class Meta:
    ordering = ['-create_date']
    # 생성된 날짜의 내림차순으로 정렬
def __str__(self):
    return self.name

@python_2_unicode_compatible
class Post(models.Model):
title = models.CharField(max_length=30)
content = models.TextField()
create_date = models.DateTimeField(auto_now_add=True)
modify_date = models.DateTimeField(auto_now=True)
user = models.ForeignKey(User)
slug = models.SlugField(allow_unicode=True,default='slug')

class Meta :
    ordering = ['-create_date']

def __str__(self):
    return self.title

def get_absolute_url(self):
    return reverse('blog:post_detail',args=(self.id,))
# post.get_absolute_url args
# 객체가 지칭하는 url 반환
def get_previous_post(self):
    return self.get_previous_by_create_date()
#create_date 기준으로 이전 포스트 반환
# get_previous_by_column 내장객체 호출
def get_next_post(self):
    return self.get_next_by_create_date()

@python_2_unicode_compatible
class Reple(models.Model):
content = models.TextField()
user = models.ForeignKey(User)
Post = models.IntegerField() # post_id
create_date = models.DateTimeField(auto_now_add=True)

class Meta:
    ordering = ['-create_date']
def __str__(self):
    return self.content

It's my first time writing, so I don't know how to Indent. Sorry
And if my code is not effective, tell me how to fix it.
thank you!

A: It might be easier to write the view from scratch as a function, but you can also override the existing post method to return additional data.


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