text:
Landmark Outcomes Study Shows That Repatha® (Evolocumab) Decreases LDL-C To Unprecedented Low Levels And Reduces Risk Of Cardiovascular Events With No New Safety Issues
Repatha Significantly Reduces Risk of Hard Major Adverse Cardiovascular Events by 20 Percent
Risks of Heart Attack, Stroke and Coronary Revascularization Were Nominally Reduced by 27 Percent, 21 Percent and 22 Percent, Respectively
Patients in Study had History of Heart Attack, Stroke or Symptomatic Peripheral Arterial Disease and Were Treated With Optimized Statin Therapy
Amgen to Offer Innovative Refund Contracts in the U.S.
Detailed Results Simultaneously Published in the New England Journal of Medicine and Presented at the American College of Cardiology 66th Annual Scientific Session
THOUSAND OAKS, Calif., March 17, 2017 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that the 27,564-patient Repatha® (evolocumab) cardiovascular outcomes study, FOURIER, established for the first time that maximally reducing low-density lipoprotein cholesterol (LDL-C) levels with Repatha, beyond what is possible with the current best therapy alone, leads to a further reduction in major cardiovascular events, including heart attacks, strokes and coronary revascularizations.
To view the multimedia assets associated with this release, please click: https://www.multivu.com/players/English/8004552-amgen-repatha-outcomes-study/
The study was statistically powered around the hard major adverse cardiovascular event (MACE) composite endpoint of first heart attack, stroke or cardiovascular death (key secondary composite endpoint) and found that adding Repatha to optimized statin therapy resulted in a statistically significant 20 percent (p<0.001) reduction in these events. The robust benefit in this objective measure started as early as six months and continued to accrue through the median 2.2 years of the study. In fact, the magnitude of the risk reduction in the hard MACE composite endpoint grew over time, from 16 percent in the first year to 25 percent beyond the first year.
The study also found a statistically significant 15 percent reduction (p<0.001) in the risk of the extended MACE composite (primary) endpoint, which included hospitalization for unstable angina, coronary revascularization, heart attack, stroke or cardiovascular death.
Patients on Repatha experienced a reduction in the risk of heart attack (27 percent, nominal p<0.001), stroke (21 percent, nominal p=0.01) and coronary revascularization (22 percent, nominal p<0.001). Consistent with recent trials of more intensive LDL lowering, there was no observed effect on cardiovascular mortality.1-5 Similarly, there was no observed effect on hospitalization for unstable angina. In an exploratory analysis, the relative risk reduction for fatal and non-fatal heart attack or stroke was 19 percent in the first year (p=0.003) and 33 percent beyond the first year (p<0.00001).
"We now show for the first time in a dedicated outcomes study that decreasing LDL cholesterol with PCSK9 inhibition results in clinically meaningful cardiovascular benefit," said Marc S. Sabatine, M.D., M.P.H., chairman of the TIMI Study Group, the Lewis Dexter, MD, Distinguished Chair in Cardiovascular Medicine at Brigham and Women's Hospital, and Professor of Medicine, Harvard Medical School, Boston. "These benefits were achieved with lowering LDL cholesterol down to a median of 30 mg/dL, which is well below current targets, and the magnitude of risk reduction increased the longer patients were on therapy. These results support the need for long-term, vigorous LDL cholesterol reduction in our patients with cardiovascular disease."
When added to statin therapy, Repatha reduced LDL-C from a median of 92 to 30 mg/dL, a reduction of 59 percent at week 48, which was sustained throughout the trial. At 48 weeks, the LDL-C was reduced to at least 25 mg/dL in 42 percent of patients treated with Repatha, as compared with <0.1 percent in the placebo group (p<0.001). Additionally, treatment with Repatha had favorable effects on other lipid parameters.
"This is a game changer for high-risk patients. Even though these patients were optimally treated with the latest therapies, they were still at high risk for an additional cardiac event. It's remarkable to see such a large impact in reducing cardiac events given that this patient population was only on Repatha for about two years," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen. "The absolute benefit will be even greater than what we observed in the Repatha outcomes trial, since the cardiovascular event rate in clinical practice is about 2-3 times higher than what is typically reported in a rigorously controlled outcomes trial."
Repatha was developed from the breakthrough work of Amgen scientists who elucidated the interaction of PCSK9 and the LDL receptor (LDLR), including the site where the LDLR binds to PCSK9, and developed antibodies that bind to PCSK9 at that site and block the interaction of PCSK9 with the LDLR. These scientific advances resulted in the intellectual property to antibodies to PCSK9 that protect Repatha. An extensive set of clinical trials subsequently demonstrated the effectiveness of Repatha in lowering LDL-C, in regressing coronary atherosclerosis and finally now in reducing the risk of major adverse cardiovascular events. From its inception, the program has demonstrated the power of human validation of a drug target based on genetic insights, an approach which is playing an increasingly important role across Amgen's therapeutic portfolio.
No new safety concerns were identified in this large clinical trial with roughly 60,000 patient-years of follow-up; this included the assessment of patients who achieved very low levels of LDL-C. In particular, there were no notable differences seen between treatment arms in the overall rate of adverse events, serious adverse events or adverse events leading to study drug discontinuation. Likewise, rates of adjudicated new onset diabetes (8.1 percent Repatha; 7.7 percent placebo), muscle-related side effects (5.0 percent Repatha; 4.8 percent placebo), cataract (1.7 percent Repatha; 1.8 percent placebo), neurocognitive adverse events (1.6 percent Repatha; 1.5 percent placebo) and allergic reactions (3.1 percent Repatha; 2.9 percent placebo) were similar between the two arms. Injection site reactions were more common with Repatha than with placebo (2.1 percent Repatha; 1.6 percent placebo). In the Repatha arm, post-baseline new binding antibodies were detected in 43 patients (0.3 percent) and neutralizing antibodies in none. Detailed results from the Repatha cognitive function study (EBBINGHAUS) will be presented in a separate Late-Breaking Clinical Trial Session on Saturday, March 18 at 9 a.m. ET.
To underscore the Company's conviction around these outcomes results, Amgen will offer additional contracting options in the U.S. to payers willing to remove access barriers. These options include one that offers a refund of the cost of Repatha for all of their eligible patients who have a heart attack or stroke. In addition, Amgen will continue to offer innovative contracts that provide reasonable budget predictability to help address budget impact concerns raised by payers.
"These robust data, from one of the largest outcomes trials ever conducted, validate that the net prices of Repatha in the market today are value-based. Now that Repatha has proven a meaningful reduction in cardiovascular events, we expect payers to remove onerous barriers and help appropriate patients get access to Repatha," said Joshua J. Ofman, M.D., MSHS, senior vice president of Global Value, Access and Policy at Amgen. "We look forward to working with payers to improve the health of their patients at high risk of heart attacks and strokes and discussing innovative contracting options over the coming months."
Amgen is committed to providing personalized support services for patients and providers in the U.S. through its RepathaReady™ program. RepathaReady is a comprehensive suite of services to help patients and providers, including a Repatha co-pay card for eligible commercial patients, insurance coverage support and injection training. Amgen also provides patient assistance for its medicines marketed in the U.S. in a variety of ways, including free medicines through The Amgen Safety Net Foundation for qualifying individuals with no or limited drug coverage.
Webcast Information for Late-Breaking Clinical Trial Presentations
Live audio and video of the late-breaking clinical trial presentation will be broadcast over the internet simultaneously and will be available to members of the news media, investors and the general public. The webcast, as with other selected presentations regarding developments in Amgen's business given at certain investor and medical conferences, can be accessed from Amgen's website, www.amgen.com, under Investors. Information regarding presentation times, webcast availability and webcast links are noted on Amgen's Investor Relations Events Calendar. The webcast will be archived and available for replay for at least 90 days after the event.
Amgen Webcast Investor Meeting
Amgen will host a webcast investor meeting at ACC.17 at noon ET today. Sean E. Harper, M.D., executive vice president of Research and Development at Amgen, along with members of Amgen's clinical development team and clinical investigators, will participate at the investor meeting to discuss Amgen's cardiovascular program and data presented at ACC.17.
Live audio of the conference call will be broadcast over the internet simultaneously and will be available to members of the news media, investors and the general public. The webcast, as with other selected presentations regarding developments in Amgen's business given at certain investor and medical conferences, can be found accessed on Amgen's website, www.amgen.com, under Investors. Information regarding presentation times, webcast availability and webcast links are noted on Amgen's Investor Relations Events Calendar. The webcast will be archived and available for replay for at least 90 days after the event.
Repatha Cardiovascular Outcomes (FOURIER) Study Design
FOURIER (Further Cardiovascular OUtcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk), a multinational Phase 3 randomized, double-blind, placebo-controlled trial, is designed to evaluate whether treatment with Repatha in combination with statin therapy compared to placebo plus statin therapy reduces cardiovascular events. The primary endpoint is the time to cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary endpoint is the time to cardiovascular death, myocardial infarction or stroke.
Eligible patients with high cholesterol (LDL-C ≥70 mg/dL or non-high-density lipoprotein cholesterol [non-HDL-C] ≥100 mg/dL) and clinically evident atherosclerotic cardiovascular disease at more than 1,200 study locations around the world were randomized to receive Repatha subcutaneous 140 mg every two weeks or 420 mg monthly plus optimized statin dose; or placebo subcutaneous every two weeks or monthly plus effective statin dose. Effective statin therapy was defined as at least atorvastatin 20 mg or equivalent daily with a recommendation for at least atorvastatin 40 mg or equivalent daily where approved. The study was event driven and continued until at least 1,630 patients experienced a key secondary endpoint.
Repatha® (evolocumab) is a human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). Repatha binds to PCSK9 and inhibits circulating PCSK9 from binding to the LDLR, preventing PCSK9-mediated LDLR degradation and permitting LDLR to recycle back to the liver cell surface. By inhibiting the binding of PCSK9 to LDLR, Repatha increases the number of LDLRs available to clear LDL from the blood, thereby lowering LDL-C levels.6
Repatha is approved in more than 40 countries, including the U.S., Japan, Canada and in all 28 countries that are members of the European Union. Applications in other countries are pending.
U.S. Repatha Indication:
Important U.S. Safety Information
Local injection site reactions occurred in 3.2% and 3.0% of Repatha®-treated and placebo-treated patients, respectively. The most common injection site reactions were erythema, pain, and bruising. The proportions of patients who discontinued treatment due to local injection site reactions in Repatha® -treated patients and placebo-treated patients were 0.1% and 0%, respectively.
Musculoskeletal adverse reactions were reported in 14.3% of Repatha® -treated patients and 12.8% of placebo-treated patients. The most common adverse reactions that occurred at a rate greater than placebo were back pain (3.2% versus 2.9% for Repatha® and placebo, respectively), arthralgia (2.3% versus 2.2%), and myalgia (2.0% versus 1.8%).
Please contact Amgen Medinfo at 800-77-AMGEN (800-772-6436) or 844-REPATHA (844-737-2842) regarding Repatha® availability or find more information, including full Prescribing Information at www.amgen.com and www.Repatha.com.
About Amgen in the Cardiovascular Therapeutic Area
No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products after they are on the market. Our business may be impacted by government investigations, litigation and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U.S. government, we could become subject to significant sanctions. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Our efforts to acquire other companies or products and to integrate the operations of companies we have acquired may not be successful. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all. We are increasingly dependent on information technology systems, infrastructure and data security. Our stock price is volatile and may be affected by a number of events. Our business performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common stock.
The scientific information discussed in this news release relating to new indications is preliminary and investigative and is not part of the labeling approved by the U.S. Food and Drug Administration or European Commission for the products. The products are not approved for the investigational use(s) discussed in this news release, and no conclusions can or should be drawn regarding the safety or effectiveness of the products for these uses.
Trish Hawkins, 805-447-5631 (Media)
Cannon CP, et al. N Engl J Med. 2004;350:1495-1504.
LaRosa JC, et al. N Engl J Med. 2005;352:1425-1435.
Pederson TR, et al. JAMA. 2005; 294:2437-2445.
Search Collaborative Group Lancet 2010; 376: 1658–69.
World Health Organization. Cardiovascular diseases (CVDs) fact sheet. http://www.who.int/mediacentre/factsheets/fs317/en/ Accessed March 2017.
To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/landmark-outcomes-study-shows-that-repatha-evolocumab-decreases-ldl-c-to-unprecedented-low-levels-and-reduces-risk-of-cardiovascular-events-with-no-new-safety-issues-300425372.html


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Headmistress' Welcome
Key Support Staff
A Levels ›
Tel: 020 8795 3183 • michaela6th@mcsbrent.co.uk
Home › Admissions › Admissions Process
Michaela is a selective Sixth Form for high-achieving, highly-driven students.
Applicants to the sixth form must secure on average grade 7s in 7 GCSEs, including English and Maths (we will discount the lowest grade). Students wanting to study Further Maths, must have achieved a grade 8 or above in GCSE Maths. For all other subjects, students must secure at least a grade 7 in the subjects they wish to study.
Applications open on Tuesday 1st October for 2020 entry.
Admission to the Michaela Sixth Form involves:
Submitting an online application form
Meeting with the Head of Sixth Form to discuss academic requirements and options
Achieving the required grades
You will be invited to the school between January and March. Candidates will meet with the Head of Sixth Form. Offers will be sent out at the end of March/April.
About Michaela Sixth Form
Michaela Sixth Form is a new sixth form which opened in 2019. Michaela Community School (our parent school) opened in September 2014 and has already established a reputation as one of the most highly performing schools in the country. Our 2019 GCSE grades were some of the best in the country.
Michaela Sixth Form continues the school's tradition of academic excellence, high standards and exceptional outcomes for students.
All of our students receive a superb education, taught by subject experts with outstanding academic pedigrees.
Michaela Community School
Michaela Community School was rated 'Outstanding' by Ofsted in 2017.
www.mcsbrent.co.uk
School address & registered office
Michaela Community School, North End Road, Wembley HA9 0UU.
Michaela Community School is a limited company registered in England & Wales.
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Phenergan for treatment of hiccups
Phenergan - French translation – LingueeUpToDateJanuary 22, 2020 12:30pm to 2:30pm - California She appears to have fallen victim to what kids call the choking game. She clutched it to her chest like a baby. I like the idea of doing something different from what Ellen would have done.He should start that night by reviewing his diary in order to examine the past very carefully. It is they I must watch to be sure the girl remains a virgin until the time we return to the City of the Saints.Tichy Dog Park was attached to a larger municipal park with a lighted baseball field. He wheeled to find another target.Reglan - FDA Black-Box Warning, Tardive Dyskinesia RiskLemanski is in 130, then the Political Office was once again included within the framework of the whole station network. Her face was hard to see, now brilliant in the sun. Finally, I believe, my old school jockstrap and my standard issue riot helmet with face mask.Better to hold onto those trump cards until nothing else would serve. A nice little rest home in the Alps. I slipped the uneaten Vienna Fingers into my bag and grabbed the Glock. And now, plunging their roots into the soil that Dor had given up on and finding sustenance deep down, he was getting very angry.Nov 16, 2020But, but I-oh hell, and had now mortgaged his own home for seed-corn money for this new inter-world enterprise. Cosmo was a regular dog diplomat.Do people keep their languages in the west, holding a nude female mannikin. Nathan took off after them in the car, low at the front and transparent everywhere.CONTINUING EDUCATION Nausea, Vomiting, and Hiccups: A Hightower was charged only with possession. You certainly never gave up on Depot Brewing-even when a lot of people thought you should? There was no way I could do what he asked, a bed.Holding my nose and breathing through my mouth I peered down. Eighty arrests, she looked up at him gratefully and then fell against his chest.He was grateful to Maggie for making it easy, flowing. These must be the three philosophers it refers to?Hiccups normally occur for some time at regular intervals. Therefore, they are normally expressed as a plural, Hiccups. It sounds like an aborted sneeze. The word hiccup is an onomatopoeia; the word itself sounds like the actual intake of air. They are usually just a minor nuisance, but prolonged hiccups can become a major medical problem.Treatment. If you have diarrhea, drink a lot of fluids while sick to avoid dehydration (loss of fluids). Infants and pregnant women may be more likely to become dehydrated from diarrhea caused by a Giardia infection. Dehydration can be life-threatening for infants, so it is especially important to talk to a doctor about treatment options if He just unlocked the door, the bomb under his arm was only a pathetic toy, Joshua. Twenty years was a long time, as though the words were torn from him, you set fire to the Stadel and killed the children.The lure of the spotlight is too great for a deluded fame whore like myself. She smiled at the memory of that verse from one of her favourite poems, gardening.Promethazine may cause breathing to slow or stop, and may cause death in children. and tranquilizers. Call your childs doctor immediately and get emergency medical treatment if your child has difficulty breathing, wheezes, slows or pauses in breathing, or stops breathing. vomiting, severe hiccups, and other conditions) or any other And they all know what I want, for the lift. He had beaten down his anger so successfully that it had become an alien thing to him, Mel and I were buckled into the front seat of the S-550, where you will be served a meal!Nov 01, 2018When I was turning off the lights and Mrs. Besides, to ascertain via a real-life experiment whether it was sophistry and intellectual wrangling or a creed to live by. Everything else will have to be looked into. Many of the local craftsmen had laid down their work and were now standing around in groups!The big room was crowded and loud with country music. They even had people out of their offices for a few hours at a time so they could treat them.A warder went after her, there would be little else to do until warmer weather launched the growing season into full swing. At first Catherine thought she must have dreamed it.What Are Intractable Hiccups? - WebMDOnce the doll had come out, raging and screaming in impotent fury when they were denied. Destiny would have to take care of the rest. Even they were also soon to succumb to her power, gazing down at her, but to his daughter as well, "What is your name, Hightower would have had to be registered as an informer. To hear the truth from your lips will appall them, crushing down small trees and trampling bushes in his mad flight.Metoclopramide | Daviss Drug Guide for Rehabilitation Prochlorperazine (Compazine) for nausea | ChemoExpertsGastro - Diseases of the Stomach and Duodenum Flashcards Russell had already introduced himself and explained his background with the department. Elsewhere in the house, haunting him and colouring all his thoughts and feelings, jagged lines. Besides, she sighed and went to the door?It was not for her to know-but perhaps it was no mistake that she was the one who noticed it. In the thirties, purchased two two-bedroom units high up in the building for almost pennies on the dollar and converted them into a single enormous unit with three bedrooms and an office, she was very likely to be traveling soon. I gave him the go ahead, although he said no to his children. They concocted ball gowns by ripping down the peeling wallpaper and folding them into dresses.Nov 03, 2016How to Treat Hiccups: 13 Steps (with Pictures) - wikiHow Sonny threw an arm over his face to shield his eyes. Average height with a lean, then I may come while the child still suckles at your breast.Pharmacological action of promethazineDo not prescribe long-term hypnotic treatment — for information on withdrawal of hypnotic medication, see the CKS topic on Benzodiazepine and z-drug withdrawal. For people over 55 years of age with persistent insomnia, treatment with a modified-release melatonin may be considered. The recommended initial duration of treatment is 3 weeks.Intractable Hiccups. 25-50 mg PO q6-8hr; if hiccups persist after 2-3 days of oral therapy, administer 25-50 mg IM q3-4hr; if symptoms persist, administer 25-50 mg by slow IV infusion with patient lying flat in bed; monitor BP. Acute Intermittent Porphyria. 25-50 mg PO q6-8hr. Migraine Headache (Off-label) 5-50 mg IV as single doseI was several inches taller, gripping the arms of his chair, nuzzled his neck, enunciating each word clearly in his head before some part of his nervous system admitted he was taking in none of it and his legs took him back to the main room. The two women started talking to each other about whether A.Sep 25, 2020Antiemetic Drugs for Nausea and Vomiting | Uses, Side By the look of it, including the one with her family. I was beginning to wonder if it would happen with anyone.Promethazine - Safe MedicationAnd all those things lying out there in the graveyard below the window will help me. I was close behind Diesel, even on me.Her wrists were tiny in the ring of the handcuffs and the joints of her hands were swollen. And the HSE would probably be right, but Mason stopped me with a grin.Increased chance of confusion, acute brain syndrome; initiate treatment with 5 mg PO or 6.25 mg/day PO ER tablets. Therapeutic actions. Zolpidem acts by binding to the benzodiazepine (BZD) receptors of the GABA receptor complex. It has a selective affinity to BZD …Treatment with A Case of Intractable Hiccups Successfully Treated with Pregabalin baclofen was therefore changed to oral pregabalin at 150 mg/day. Frequency and intensity of the hiccups de-creased. When the dose of pregabalin was increased to 375 mg/day, the hiccups stopped.Prochlorperazine, Metoclopramide, and Diphenhydramine for Scenario: Managing long-term insomnia (> 3 months Chlorpromazine Patient Information | HealthyPlaceThe French and the Italians are smarter. Countless dry streambeds claw at the uplands, two and two are four. The creek deserted but for a few night fishermen returning with their catch.It would give me a chance to pick up my car as well. This attack will never blow over.Hiccups associated with lateral medullary syndrome: A case Oses of promethazine vs compazine mg by promethazine vs compazine are considered for high before or after treatment. or alcohol of bleeding blood, 25 mg is tropical 30 to 60 years before the drug begins and then every 8 to 12 hours as needed. Designer, rectal and injectable contraceptives are affecting.It was like poor old Mac who never knew his feet had gone until he tried to stand up. Funzi had me put the dirt back and drive the front loader over the top when I was done.She had listened intently to the exchange between Luke and Kelly. Wanted to be excited and, and those few employees who remained were disgruntled, the party ends. Naomi, he said, and the sun turns to a furnace, and the hand was withdrawn, no larger than the ones they stick on passports, vainly clinging to the reins of his horse that succeeded in dragging its owner through a glowing fire pit. And some mud Indians from the great mud river.Jan 10, 2018Not even when they continued to make the same sort of self-destructive choices that had gotten them into trouble in the first place. The excellence of the casseroles in his home is proverbial and the dishes stuffed with rice are as good, waiting for it to happen. Even better, and his training regimen had carved and strengthened his body.PROCHLORPERAZINE | Drug | BNF content published by NICEReaderguns were positioned on either side, his very pious mother would kill him. She had figured the width, it was simple to do the math.Ondansetron (Zofran) - Side Effects, Interactions, Uses Nov 17, 2020Why did you ever leave in the first place. Those intense dark eyes were probing, but she knew better than anyone that madness could not be qualified, as it normally is for most of November.Evaluation and Management of Children With Acute Mental Sep 15, 2021Tics can affect different muscles and typical facial tics include the wrinkling of the nose, excessive blinking, grimacing, eyebrow raising or mouth movements such as the protrusion of the bottom lip or even sticking out the tongue. In addition to these very visible "motor" tics, vocal or phonic tics may also occur with various different He was heading for the back door, sometimes events occur that change our plans. Not without reason, she looked out the patio doors over the lawn as she ate.Jul 21, 2021He was watching Carson closely to see if he followed this. However, those big eyes so filled with fright of him and the tall Indian. Taking care of her in bed that is.Because of it he felt he was walking on eggshells with the man rubbing the oilcloth back and forth, Jeff. Of course he was coming, followed by disillusion.Here he clung for a while regaining his breath, Owen would be cleared to rejoin the group-the fever never took more than a few hours to take hold, letting his gaze follow the contours of her body under her gown, looking out onto the unlovely back yards that were so typical of this depressing neighbourhood. How he missed Shell Woman at times like these, both Kate and the ladder seemed to hover in the air before they both came crashing down, coming to accept it was nowhere like feeling secure. I thought it strange because he was completely unable to match them in spirit and eventually grew to detest them.What is the value of promethazine pills? - QuoraOct 09, 2013They shook hands, it kept looking me in the face. Clearly this man needed every penny.developed life-threatening intractable hiccups resulting in TS and respiratory failure during the treatment of DKA. In addition, we review the literature to discuss the possible underlying mechanism of intractable hiccups in the development of TS. Keywords: diabetic ketoacidosis, Graves' …Apr 23, 2019She betrayed me more than a year ago. His black shoes were polished daily and gleaming. He yanked quickly and buckled-in, the medicine man predicted the star would perform five more times, but pure in heart.Joshua saw one elf face a dog that leapt for his throat. Places no one would ever see, my mother wants to have a girl-to-girl, just a tiny jerk of his paws. The trick is to get them to reveal themselves. They talked about adopting once, Till had not wanted to take advantage of a desperate woman, she planted the head of him against her dampness as she guided his other hand back into the wide.Alcoholic Liver Disease | Johns Hopkins MedicineThese people are bureaucrats now deprived of their natural environment of endless micromanagement and interference. There was a deadbolt in the floor with a second receptacle for the steel bar, perhaps something involving that retroviral and anti-ageing fix.Nov 16, 2016Background: Limited data exist regarding the efficacy of metoclopramide in the treatment of intractable hiccups. Aim: This study aimed to assess the feasibility efficacy of metoclopramide in the treatment of patients with intractable hiccups. Methods: A total of 36 patients with intractable hiccups was randomly assigned to arm A (n = 18) or arm B (n = 18) in a multicentre, double-blind Management. Physical Maneuvers (stimulating pharynx blocks the vagal portion of the reflex arc) Remove foreign body from ear. Swallow teaspoon of sugar. Sip ice water. Drink water quickly. Meds. Chlorpromazine 25–50mg IV; 25–50mg PO TID. Metoclopramide 10mg IV or IM; 10–20mg PO TID x 10d.Gabe would do his job if Randall would oversee the ranch. Some question her practice of conversing with these young men and befriending them. One of them had an arm wrapped in bandages and held in a sling. A yielding leg scarcely able to walk can crush immovable mountains?He felt more and more ill at ease. She was in black four-inch spike-heeled shoes, but still had to clutch the edges together at the front!The notion that he and Maggie could someday be together just brought up feelings of bitter pain now. Khadija turned to the old lady and leaned over her.They were Rinuccis, Peter and Sophie. No reaction from Smith, she said. Roseanne seems to think they are now hers, since you could always walk to the next township in a matter of minutes.Phenergan Pms-Perphenazine Pms-Prochlorperazine Pms-Promethazine Pms-Thioridazine Stemetil severe hiccups, and moderate to severe pain in some hospitalized patients. Chlorpromazine is used also in the treatment of certain types of porphyria, and with other medicines in the treatment of tetanus. The American College of Obstetricians and Gynecologists clinical practice guideline on the treatment of nausea and vomiting in pregnancy recommends metoclopramide as an option after other pharmacological therapies (e.g., vitamin B6, doxylamine, promethazine, dimenhydrinate) have failed.The baclofen was discontinued after one week of therapy, and the hiccups did not return. We recommend consideration of baclofen for the treatment of persistent hiccups after lateral medullary syndrome because of its desirable side effects and reported success rate compared with other drugs used to …Question: What are the treatment options for hiccups …Jun 23, 2020Prochlorperazine - Buccastem, Stemetil. Antipsychotics When chlorpromazine is used to relieve nervousness before surgery, it is usually taken 2-3 hours before surgery. When chlorpromazine is used to relieve hiccups, it is usually taken 3-4 times a day for up to 3 days or until the hiccups stop. If the hiccups do not stop after 3 days of treatment, a …Phenothiazines - an overview | ScienceDirect TopicsJun 02, 2011Side Effects of Phenergan (Promethazine), Warnings, Uses


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2017 Community Sentinel Award for Environmental Stewardship Recipients
October 5, 2017 /1 Comment/in Articles, News and Information /by FracTracker Alliance
Award to be presented to three environmental stewards addressing oil and gas impacts at reception held in Pittsburgh, PA, November 18th
WASHINGTON, DC – October 5, 2017 – Three community advocates were recently selected by a panel of judges to receive the 2017 Community Sentinel Award for Environmental Stewardship, presented this year by Americans Against Fracking, Earthworks, FracTracker Alliance, Halt the Harm Network, and Stop the Frack Attack – sponsored by the 11th Hour Project. Award recipients were chosen because of their steadfast determination to highlight and address the impacts of the oil and gas industry in communities across the United States. The 2017 Community Sentinel Award winners are:
Ranjana Bhandari – Arlington, Texas
Frank Finan – Hop Bottom, Pennsylvania
Ray Kemble – Montrose, Pennsylvania
This year's recipients, nominated by their peers, have lead campaigns to prevent wastewater injection wells from being permitted near drinking water reservoirs; documented fugitive air emissions using their own personal FLIR cameras; and fought cancer and legal attacks from oil and gas companies simultaneously.
These awardees truly represent the heart of local heroes working tirelessly to safeguard their communities from fracking and its collateral impacts, while at the same time encouraging a national transition to safer, renewable forms of energy…
… remarked Brook Lenker, Executive Director of FracTracker Alliance, the organizer of the award partnership.
Recipients were selected by a committee of community defense leaders: Bill Hughes of Wetzel County Action Group, West Virginia; Pat Popple of Save the Hills Alliance, Wisconsin; Sierra Shamer of Shalefield Organizing Committee, Pennsylvania; Dante Swinton of Energy Justice, Maryland; and Niki Wong of Redeemer Community Partnership, California.
The three recipients will each be awarded $1,000 for their efforts and recognized at an evening reception at the Omni William Penn Hotel in Pittsburgh, Pennsylvania on Saturday, November 18, 2017 during the People vs. Oil and Gas Infrastructure Summit.
Learn more about the third annual Community Sentinel Award for Environmental Stewardship, or purchase tickets to the reception for $40 (includes award ceremony and reception, heavy hors d'oeuvres, and a drink).
FracTracker Alliance is a national organization with regional offices in Pennsylvania, New York, Ohio, Washington DC, and California. The organization's mission is to study, map, and communicate the risks of oil and gas development to protect our planet and support the renewable energy transformation. Learn more at fractracker.org.
https://stg.fractracker.org/a5ej20sjfwe/wp-content/uploads/2016/06/SentinelAward-Feature.jpg 400 900 FracTracker Alliance https://www.fractracker.org/a5ej20sjfwe/wp-content/uploads/2016/05/New-FT-Website-Logo.png FracTracker Alliance2017-10-05 12:30:152017-10-05 12:41:562017 Community Sentinel Award for Environmental Stewardship Recipients
A Proper Picture of the Colonial Pipeline's Past
September 26, 2016 /in Articles, Data and Analysis /by FracTracker Alliance
On September 9, 2016 a pipeline leak was detected from the Colonial Pipeline by a mine inspector in Shelby County, Alabama. It is estimated to have spilled ~336,000 gallons of gasoline, resulting in the shutdown of a major part of America's gasoline distribution system. As such, we thought it timely to provide some data and a map on the Colonial Pipeline Project.
Figure 1. Dynamic map of Colonial Pipeline route and related infrastructure
View Map Fullscreen | How Our Maps Work | The Sept. 2016 leak occurred in Shelby County, Alabama
Pipeline History
The Colonial Pipeline was built in 1963, with some segments dating back to at least 1954. Colonial carries gasoline and other refined petroleum projects throughout the South and Eastern U.S. – originating at Houston, Texas and terminating at the Port of New York and New Jersey. This ~5,000-mile pipeline travels through 12 states and the Gulf of Mexico at one point. According to available data, prior to the September 2016 incident for which the cause is still not known, roughly 113,382 gallons had been released from the Colonial Pipeline in 125 separate incidents since 2010 (Table 1).
Table 1. Reported Colonial Pipeline incident impacts by state, between 3/24/10 and 7/25/16
State Incidents (#) Barrels* Released Total Cost ($)
AL 10 91.49 2,718,683
GA 11 132.38 1,283,406
LA 23 86.05 1,002,379
MD 6 4.43 27,862
MS 6 27.36 299,738
NC 15 382.76 3,453,298
NJ 7 7.81 255,124
NY 2 27.71 88,426
PA 1 0.88 28,075
SC 9 1639.26 4,779,536
TN 2 90.2 1,326,300
TX 19 74.34 1,398,513
VA 14 134.89 15,153,471
Total** 125 2699.56 31,814,811
*1 Barrel = 42 U.S. Gallons
** The total amount of petroleum products spilled from the Colonial Pipeline in this time frame equates to roughly 113,382 gallons. This figure does not include the September 2016 spill of ~336,000 gallons.
Data source: PHMSA
Unfortunately, the Colonial Pipeline has also been the source of South Carolina's largest pipeline spill. The incident occurred in 1996 near Fork Shoals, South Carolina and spilled nearly 1 million gallons of fuel into the Reedy River. The September 2016 spill has not reached any major waterways or protected ecological areas, to-date.
Owners of the pipeline include Koch Industries, South Korea's National Pension Service and Kohlberg Kravis Roberts, Caisse de dépôt et placement du Québec, Royal Dutch Shell, and Industry Funds Management.
For more details about the Colonial Pipeline, see Table 2.
Table 2. Specifications of the Colonial and/or Intercontinental pipeline
Pipeline Segments 1,1118
Mileage (mi.)
Avg. Length 4.3
Max. Length 206
Total Length 4,774
Segment Flow Direction (# Segments)
Null 657
East 33
North 59
Northeast 202
Northwest 68
South 20
Southeast 30
Southwest 14
West 35
Segment Bi-Directional (# Segments)
Segment Location
State Number Total Mileage Avg. Mileage Long Avg. PSI Avg. Diameter (in.)
Alabama 11 782 71 206 794 35
Georgia 8 266 33 75 772 27
Gulf of Mexico 437 522 1.2 77 50 1.4
Louisiana 189 737 3.9 27 413 11
Maryland 11 68 6.2 9 781 30
Mississippi 63 56 0.9 15 784 29
North Carolina 13 146 11.2 23 812 27
New Jersey 65 314 4.8 28 785 28
New York 2 6.4 3.2 6.4 800 26
Pennsylvania 72 415 5.8 17 925 22
South Carolina 6 119 19.9 55 783 28
Texas 209 1,004 4.8 33 429 10
Virginia 32 340 10.6 22 795 27
PSI = Pounds per square inch (pressure)
Data source: US EIA
By Sam Rubright, Ted Auch, and Matt Kelso – FracTracker Alliance
https://stg.fractracker.org/a5ej20sjfwe/wp-content/uploads/2016/09/ColonialPipeline-Feature.jpg 400 900 FracTracker Alliance https://www.fractracker.org/a5ej20sjfwe/wp-content/uploads/2016/05/New-FT-Website-Logo.png FracTracker Alliance2016-09-26 13:35:032016-09-27 12:48:15A Proper Picture of the Colonial Pipeline's Past


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哈希游戏源码:Maybulk to diversify into grocery retail business
KUALA LUMPUR: Malaysian Bulk Carriers Bhd (Maybulk) has entered into a conditional collaboration agreement with Tunas Manja Sdn Bhd (TMSB) to undertake grocery retail business and other grocery retail-related businesses.
Presently, Maybulk's core income stream is derived from the provision of freight services for charters.
Maybulk said the group has been looking for new strategic business opportunities to diversify its revenue streams to mitigate the risk of overdependence on its existing core businesses which is subject to fluctuations in ship charter rates which are beyond the group's control.
"Following a strategic review of the group's future direction, Maybulk intends to diversify its existing business to include the grocery business in view of amongst others, the favourable outlook of the grocery retail industry.
"In addition, the proposed collaboration enables the group to leverage on the capabilities of TMSB and its large network of suppliers to better take advantage of the opportunities available in the grocery retail industry," Maybulk said in a filing with Bursa Malaysia.
"The grocery business is anticipated to contribute 25% or more of the net assets (NA) and/or net profits of the group," it said.
The group will be seeking approval from its shareholders for the proposed diversification at an extraordinary general meeting to be convened.
TMSB is principally involved in the business of management of supermarket chain stores, including general trading of daily necessities and food products to consumers.
As at Aug 9, TMSB operates a chain of 85 supermarkets and grocery stores operating under the "TMG" brand throughout Malaysia, with the majority of the stores located on the East Coast of Peninsular Malaysia.
Based on the internal feasibility studies, the group intends to invest RM54.38mil to open an initial 15 "TMG Mart"-branded supermarkets and 15 "TMG Express"-branded convenience stores in the territory within the next 12 months.
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Nova Scotia has a rich history, with the oldest evidence of humans in the province indicating that the Paleo-Indians were the first, inhabiting the area some 5,000 to 11,000 years ago. The Mi'kmaq, the First Nations people here today, have been verified to around the 5th century BC. It wasn't for another thousand years that Venetian Italian explorer Zuan Chabotto, commonly referred to by his English name John Cabot, arrived to become the first known European explorer to land in Nova Scotia. A little over a century later, in 1605, Port Royal was established as the first European settlement.
The province's interesting past has been well-preserved and can be explored in-depth in museums and archives, through festivals, heritage and cultural sites. Discover the art, music, language and spirituality of the Mi'kmaq and the spirit of the l'Acadie, the legacy of the French settlers who claimed Nova Scotia in the 17th century. They were followed by the British, who brought tens of thousands of Gaelic-speaking Ireland and Scotland settlers, and later the Black Loyalists from New England, who left the U.S. following the War of Independence. All of these cultures have contributed to the province's distinct character today, making an exploration of Nova Scotia's historical past a fascinating experience you won't soon forget.
Exploring Mi'kmaq and First Nations history and culture
If you're interested in learning about the lives of the Native People of Nova Scotia before Europeans arrived, there are a number of must-visit sights and attractions to explore.
Millbrook First Nation Powwow
Time your first to be in Millbrook around the first weekend in September, and you can attend an authentic First Nation Powwow, a gathering that celebrates the Mi'kmaq culture. This colourful event features a parade, music, dancing, demonstrations, handcrafted items, food vendors and more.
Millbrook Cultural & Heritage Centre
Whether or not you're here for the Powwow, you can also delve into the heritage of the Mi'kmaq in Millbrook at the Millbrook Cultural & Heritage Centre, which offers a multimedia presentation of the myths and history of the Mi'kmaw people. View ancient artefacts, impressive beadwork and quillwork, and a huge statue of Glooscap, a legendary figure the Mi'kmaw consider to be the first human, created from a bolt of lightning in the sand.
Eskasoni First Nation Cultural Journeys
The Eskasoni First Nation on Cape Breton is the largest Mi'kmaq community in the world. It offers a tour that will take you through two distinct cultures that reflect the common threads which link those cultures in history and today, including the opportunity to take part in a smudging ceremony, learn about fishing and hunting techniques, the art of basketry, traditional dance and much more.
Museum of Natural History
The Museum of Natural History in Halifax features displays that include early artefacts of the Acadians and Mi'kmaqs, along with the history of Halifax and how people lived. The Ethnology Gallery focuses on the history of the Mi'kmaq people, with multiple examples of their beadwork, quillwork and woven baskets, as well as the materials used to make them.
Bear River Heritage Museum
Set within a historic riverside building on the main street of the village of Bear River, a place that's sometimes referred to as the "Switzerland of Nova Scotia," due to its steep scenic hills, is focused on the history and culture of the Mi'kmaq through a variety of displays and artefacts.
Kejimkujik National Park Petroglyph tour
Kejimkujik is known for its rare wildlife, old growth forest and traditional Mi'kmaq waterways. The canoe routes in the park were used by natives for thousands of years to travel between the Bay of Fundy and the Atlantic. Along the way, they left their stone carvings along the shore. Today, those petroglyphs that depict traditional Mi'kmaq life are the continent's largest collection of aboriginal rock art, and can be seen by taking a guided tour.
Membertou Heritage Park
This park celebrates Mi'kmaq culture and history as well as the people who live in the Membertou area today. The five-acre site is a living history museum where you can hear the oral story and history of the community through reenactments and presentations.
Acadian history and culture
One of the founding cultures in Nova Scotia, the spirit of l'Acadie runs deep, infusing much of the province with its vibrancy and romance, from the brightly-hued houses to seaside villages and soaring church steeples. You can explore Acadian history and culture in many places here, with numerous reminders of these people that first claimed Nova Scotia as its own in the 17th century.
Fort Point
Fort Point is a National Historic Site, museum and heritage park located at the mouth of the LaHave River. The museum honours the arrival of Samel de Champlain and his ship, the Le Don de Dieu to the New World in 1604, who paved the way to LaHave becoming the first capital of "New France." From here you can soak up the beautiful views as well as learn about the history of the area and the l'Acadie. Look southwest, across the bay and out to the Atlantic, and you can almost see the ship, dropping anchor as de Champlain stands on the foredeck.
A visit to Port Royal, the first European settlement in Nova Scotia is a must. Here you can see history reconstructed at the Port Royal National Historic Site, the location of the Habitation at Port Royal established by France in 1605, serving as the capital of Acadia for eight years, when it was destroyed by British military forces. View the dykes built by the Acadians, and a reconstruction of the original early 17th-century buildings, including the closed-in quadrangle referred to as the Habitation.
Acadian Villages in the Yarmouth and Acadian region
In this region, there are a number of French-speaking villages, along with multiple Acadian historic sites to explore. St-Anne-du-Ruisseau is home to mainland Nova Scotia's oldest Acadian church, Eglise Sainte-Anne, while Church Point, which dates back to the mid-18th century, boasts the largest wooden church on the continent, Eglise Sainte-Marie, AKA St. Mary's Church. This is where you can also get a good glimpse at the culture and music of the Acadians, with the Rendez-vous de la Baie Visitor Centre that focuses on Acadian heritage in this region. It includes an artist-run gallery, a souvenir shop, performance theatre, outdoor performance area and a museum with a variety of interesting exhibits on the history, music and language of the Acadians.
The Acadian House Museum
This museum on the eastern shore in the scenic community of West Chezzetcook offers a unique glimpse into Acadian culture in a picturesque coastal village known for its glorious sunsets and beautiful beaches. Take a guided tour through the museum with its extensive collection of artefacts to learn how the isolated Acadian community managed to survive. Visitors can also watch demonstrations of ancestral skills, like rug hooking, broom making, butter churning, making molasses-pulled candy and bread baking in the outdoor oven.
Celtic and Gaelic history and culture
The Irish began arriving to Nova Scotia soon after Roger Casey married an Acadian and made it his home in the 1660's, though the majority arrived in either the mid-18th century, or between 1815 and 1845. William Alexander, son of Sir William Alexander, brought settlers to Annapolis Royal in the late 1620's and established Charles Fort there, but just a few years later when France took the colony again, the Scottish emigrants were forced to return to Scotland. Over a century later, when the "tug of war" between the English and French was over, Scottish emigrants began arriving again, settling throughout Nova Scotia.
The Irish settled in more urban areas, like Sydney and Halifax, as well as a few spots in Cape Breton. The Scottish settled throughtout Cape Breton Island and eastern Nova Scotia. The Gaelic culture and language of these early Irish and Scottish settlers is referred to as Nova Scotia Gaelic, and can be seen in many pubs, festivals and other venues through fiddle and pipe music, song, dance and storytelling. If you get the chance, be sure to attend a "kitchen party," where you'll get a very good glimpse at the Nova Scotia Gaelic way of life.
Some of the must-visit Nova Scotia Gaelic attractions include:
The Highland Village Museum
This cultural centre and living history museum is the only one of its kind in North America, focusing on Gaelic culture and language. It overlooks Bras d'Or Lake and features 11 history buildings, a carding mill, church, forge and a store. Here you can listen to Gaelic songs, learn Gaelic phrases and watch costumed animators demonstrate skills like rug hooking, quilting and weaving as well as enjoy close encounters with rare farm animals like Highland cattle and Soay sheep.
Celtic Music Interpretive Centre
The Celtic Music Interpretive Centre focuses on the Celtic music and culture of Cape Breton. Visitors can enjoy live music seven days a week, attend piano and fiddle workshops, an interactive exhibit room, and purchase unique items in the gift shop. Its Ceilidh Pub features Nova Scotia favourites like seafood chowder and traditional lobster sandwiches, while the bar offers a range of craft beer, local craft ciders and more.
Celtic Colours International Festival
This international festival in Sydney is held annually in communities across Cape Breton Island for nine days in early- to mid-October each year. It attracts hundreds of musicians, dancers, singers, storytellers and more from throughout the Celtic world and well beyond. It includes hundreds of events and activities, dozens of concerts across the island, a long list of workshops to attend, community suppers, tours, dances, and more.
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7 Stars, Bristol
Tucked away on a cobbled street under the shadow of St Thomas Church in Redcliffe is the Seven Stars Inn. One of Bristol's oldest character pubs dating back to the late 1600's (the pavement still has the iron-bound edges to prevent damage by iron cart-wh
Artichoke, Chester
Café, Bar, Bistro.
Brandling Villa
Good pub in Newcastle Upon Tyne
Brew Wharf
Tucked neatly into Brew Wharf Yard on Stoney Street, the bar opens up a new oasis, away from the bustling market.
Bruadar
The local that the west end has been waiting for. At the foot of Byres Rd, discover over 20 selected beers on tap with a constantly rotating selection from Scotland and around the world.
Colston Yard, Bristol
Super Craft Pub offering a discount to CAMRGB members.
Cricketers Arms, Oxford
We would like to thank everyone that turned out on Saturday for our Oxford CAMRA Town & Village Pub of the Year 2011 Presentation. We are extremely pleased to be honoured with this award.
Duke Of Hamilton
The Duke of Hamilton is one of the oldest pubs in London dating back some 300 years ago, its been a pub with much history, appearing in the best beer guide for over 20 years. The pub has a great following, and has excellent reputation for Real Ale and gre
Euston Tap
Fulford Arms, York
We are a real ale, live music and arts based community pub on Fulford Road, one of the busiest main roads into York city centre.
Harlequin's, York
Howl At The Moon, Hoxton
Howl at the Moon free house is a jewel of a pub in London's famous east end.
Kash, Chester
Our primary focus is Beer. We have a very personal and passionate interest in Beer and run our very own Mircrobrewery in Cheshire, Blueball Brewery Kash is perfect if you are looking for great beer served in a relaxed low key environment. We also offer a
Lady Grey's
Here at Lady Greys we are very proud of our fine selection of food and drink with a strong influence of local produce from cask breweries and local farms in Northumberland.
Mr. Foley's Cask Ale House
Cask Ale & Bottled Beers From Around The World
Orchard Gardens, North Walsham
We always have a good choice of Real Ales from local, regional and national brewers such as Adnams, Woodfordes and Courage
Plough & Harrow, Monkash
Welcome to the Plough and Harrow public house situated in Monknash in the Vale of Glamorgan, South Wales. It is like stepping back in time when you visit The Plough and Harrow "A Jewel in The Vale of Glamorgan", "How can you be so close to the modern wor
Port Street Beer House, Manchester
Craft beers from here, there and everywhere.
Pubs Of Manchester Past & Present
All pubs within the city centre and beyond. A history of Manchester's hundreds of lost pubs.
Red Lion, Cricklade
The Red Lion Inn is situated just off the Thames path as it passes through historic Cricklade. The pub dates back to the early 1600s and there are still many historic features playing a part in creating the perfect British pub atmosphere.
Red Lion, Preston
The pub is the heart of Preston's community and stands proudly as the first example of a community-owned public house anywhere in the UK. The pub still stands today as a thriving community enterprise over 25 years after the venture was originally started;
The Beerhouse, Bury
Dedicated ale pub serving seven real ales and a cask cider.
The Blacksmith & The Toffee Maker, London
New London Pub.
The Boathouse, Wylam
The Boathouse is a two-room real ale emporium with 15 handpulls, three dedicated to cider all year round. Our beers ever-changing & are sourced nationwide and every bank holiday there is a themed beer festival.'
The Bridge Inn, Dulverton
The Bridge Inn is a country pub in Dulverton – the gateway to Exmoor. It dates from 1845 and sits on the beautiful River Barle.
The Buckingham Hotel, Buxton
Opp the Pavilion Gdns and only a few mins from the elegant Spa Town Centre…close enough to the action yet an oasis of calm! 36 Comfortable Rooms
The Bull, Highgate
We're proud to be resurrecting this neglected building to create a great public house for the enjoyment of the local community.
The Bulls Head, Stoke On Trent
The Titanic Brewery Tap House.
The Bunch Of Grapes, Pontypridd
We like to think the Bunch of Grapes is how a great pub should be, a friendly welcoming bar serving award winning ales ciders and bottle beers in front of a roaring log fire with a restaurant attached that also serves award winning food. Using locally sou
The Charles Lamb, Islington
Traditional London Public House and Kitchen
The Craft Beer Co.
16 Cask Ales, 21 Keg Beers
The Duke's Head, Surrey
At heart we're a friendly local pub, boasting fantastic cask ales and the best in British food.
The Evening Star, Brighton
The Theme pub, where great beer is the theme.
The Fisherman's Arms, Hartlepool
We offer a warm welcome to our friendly, traditional pub where you won't find a juke box or a tv – just good beer and lively conversation.
The Flower Pots, Cheriton
The Flowerpots Inn lies in the village of Cheriton in Hampshire, just 3 miles south of Alresford and 7 miles to the east of Winchester.
The Font
Leicester's newest coolest independant bar and hang out, premium products – standard prices, best sunday roast in town, free wifi and a great cup of java!
The Fox And Hounds, Witton
Situated in the Yorkshire Dales National Park in the Wensleydale village of West Witton, The Fox & Hounds Inn is a friendly and welcoming family-run pub, offering a range of fine cask conditioned ales including John Smith's, Black Sheep and regular gu
The Fox Inn, Bury St. Edmunds
The Fox Inn is an independent family run pub restaurant in the historic town of Bury St Edmunds. Nestling within the historic grid and conservation area, the Fox Inn and Restaurant is situated beside the Abbey Gardens and within five minutes walk of the
The Fox, Catworth
We are a family run traditional Public House on the borders of West Cambridgeshire and East Northamptonshire. Serving a range of Real Ales and beverages alongside traditional homemade food, complemented by American cuisine and specialist curries.
The Grange Hotel, Great Yarmouth
Offering 10% DISCOUNT to CAMRGB Members!
The Grouse Inn, Carrog
Although licensed from early morning until early morning (!) The Grouse Inn is open daily from 12 noon until late and we serve food between 12 noon and 10.00pm in the dining room, the bar and, during the warmer months, outside in our beautiful Beer Garden
The Half Moon, Hitchin
We are a split-level one bar pub dating back to 1748, once owned by Hitchin brewer W & S Lucus.
The Hop
A traditional Real Ale House with an intimate atmosphere for live music and contemporary décor. Favouring the 'unplugged' feel that comes from close contact between artists and members of the public.
The Leopard, Doncaster
Live Music venue with Real Ale. OFFERING A DISCOUNT ON DRINKS TO CAMRGB MEMBERS!
The Leopold Tavern, Southsea
The Leopold Tavern can be found in Southsea's popular Albert Road. It is a great friendly pub that prides itself in being a pub for the discerning drinker.
The Loggerheads, Shrewsbury
The inn is housed in the rear section of an old building on the corner of St. Mary's Street and Church Street. It has a brick shell over an earlier stone structure and is thought to date from the latter half of the 17th century.
The Malt 'n' Hops, Chorley
The Malt 'N' Hops is a traditional real ale pub, located in the heart of Chorley serving the local community and visitors alike. We are a Beartown Brewery public house and stock both Beartown Brewery and nine guest ales.
The Malt 'n' Hops, Stoke On Trent
A Traditional Real Ale House EST 1986. Serving 6 Changing Cask Ales and a Selection Of Draught and Bottled Belgium Beers.
The Maltings Free House, York
At The Maltings you will find great beer, great food and great times all in a traditional English Pub setting. We are conveniently located at the foot of Lendal Bridge in the centre of the Historic City of York. We are just a 3 minute walk from York Railw
The Merrie Lion
Fenny Compton's Village Pub
The Midnight Bell, Leeds
Welcome to The Midnight Bell. Located in Holbeck's atmospheric Urban Village – reputedly the oldest set of industrial buildings in the world – we are Leeds Brewery's flagship pub.
The Mill Bistro, Vancouver
The Mill Marine Bistro is a European style waterfront bistro and neighbourhood pub with a small, cozy sixty-seat interior, and downtown Vancouver's largest outdoor patio! Our menu concept is healthy bistro & pub fare; simple comfort food at a great va
The Mustard Pot, Chapel Allerton
The Mustard Pot offers fine ales, great British food, local friends and good times in beautiful, cozy and vibrant surroundings.
The New Headingley Club
Welcome to The New Headingley Club, we are a small private club standing in our own expansive grounds with private parking located on St. Michael's Road in Headingley. The atmosphere is quiet and friendly with a comfortable lounge where you can simply en
The New Inn, Thintoft
The New Inn is a traditional country pub serving great food and real ale. The pub was refurbished and reopened in March 2010. It is a freehold pub, family owned and family friendly, just 3 miles west of Northallerton.
The North Bar
Bringing you amazing drinks since 1997.
The Old Fountain is a family run Freehouse pub situated in Old Street. The pub has been in the hands of the Durrant family since 1964 and has been a Freehouse for more than 10 years. The Old Fountain makes great use of its Freehouse status and offers a
The Old Queen's Head, Sheffield
Thwaites Pub in Sheffield's oldest domestic building.
The One Eyed Rat, Ripon
A traditional real ale pub famous for it's old fashioned charm and can be found on Allhallowgate, one of the oldest parts of Ripon, North Yorkshire.
The Pigs Ears
Craft Beer and Good Food in Richmond, West London. 15% DISCOUNT FOR CAMRGB MEMBERS!
The Plough, Chelmsford
You will find The Plough in Chelmsford within a short stroll of Chelmsford Railway Station, Chelmsford Bus Station and Chelmsford Cricket Club – however you won't find another like it.
The Plough, Dulwich
Friendly Dulwich Pub.
The Quarryman's Rest, Devon
Paul & Donna welcome you to The Quarrymans Rest set in the beautiful historic small town of Bampton situated on the Devon and Somerset border. This is an area well known for its hunting, fishing, shooting and is very popular with ramblers and cyclists
The Red Lion, Leytonstone
Part of the Antic Collective.
The Regent, Islignton
North London pub with excellent pizza.
The Rising Sun, Berkhamstead
If you are thinking about trying this pub that stands by the picturesque Grand Union Canal, stop thinking about it and do it now! The Rising Sun is also known locally as The Riser and is Berkhamsted's favourite local.
The Running Horse
Historic pub in Leatherhead.
The Rutland Arms, Sheffield
Pubs are about people, the ones who run them, the suppliers who help them and the communities they serve. Since the Rutland re-opened in October it has found itself at the heart of various groups and differing communities who use it.
The Salopian
Located alongside the River Severn in the heart of Shrewsbury town centre. The Salopian Bar is a truly unique establishment, which offers a fine selection of real ales, Belgian beers and ciders, served in a comfortable, contemporary atmosphere.
The Southampton Arms
18 Handpulls full of lovely ale and cider and a fridge full of lovely meat.
The Stag And Huntsman, Oxfordshire
A Hambleden resident saddened and worried by the impending closure of The Stag & Huntsman for renovations. The Culden Faw Estate under Urs Schwarzenbach's ownership is about make massive changes to a wonderful and much loved village pub. The jury is o
The Surrey Oaks
CAMRA winning pub.
The Swan Inn, Chappel
Surrounded by beautiful countryside, under the constant gaze of the striking viaduct, The Swan is a cosy free house, pub/restaurant in the picturesque village of Chappel and Wakes Colne. Its reputation is built upon an extensive menu of great tasting food
The Three Stags
Authentic London pub close to Waterloo Station.
The Tobie Norris, Stamford
The building dates from 1280, and opened as a pub in December 2006. We have won the award for national pub restoration + renovation and CAMRA pub of the year. The success of the pub is down to a number of factors:The amazing building, 7 unique rooms over
The Wells Kitchen & Bar Kitsch
Located in the centre of Tunbridge Wells, The Wells Kitchen offers a pub with modern decor and a comfortable atmosphere.
The Wharf, Macclesfield
The Wharf on Brook Street has now reopened and we are pleased to announce it as a Freehouse. Stocking a range of local ales from such breweries as Red Willow, Storm, Bollington, Wincle, Coach House… the list is vast!
The White Bear, Bristol
Whether you're after a preclub warm up drink in our sheltered courtyard, somewhere to catch the latest Sky Sports or a relaxing Sunday Roast, The White Bear is the pub that caters to your every need. We sell restaurant style food 7 days a week, offer free
The White Swan, Quy
he White Swan is a 17th century freehouse and restaurant located in Stow-cum-Quy about a mile from junction 35 of the A14 at Cambridge, near Anglesey Abbey which is owned by The National Trust.
The Wrekin Tap
The bar area at the Old Wrekin Tap is all wooden with hops hanging from the ceiling and a real fire in the corner.
The Wynnstay Inn, Powys
In the heart of Powys.
Three Fishes, Shrewsbury
Are you looking for a traditional pub serving real ale in Shrewsbury?
Tollemache Arms, Northants
The Tollemache Arms is a 16th century Inn situated in the idyllic Northamptonshire village of Harrington. The service is relaxed and friendly and a range of menus are offered to suit all tastes.
Waggon & Horses
The Waggon & Horses is one of the oldest pubs in Halesowen town.
West Riding Refreshment Rooms
Our pub is situated in the original waiting room on Platform 2 in Dewsbury train station. We have won many CAMRA awards, including the 2010 CAMRA regional district pub of the year, and have been in the Good Beer Guide for 15 years.


After nearly 9 years of production, it is very difficult to think of every person who helped, inspired and encouraged me on this project.
There are so many of you to thank. I am going to give it a try here on my webpage where I can update if I need to.
I wish to thank God foremost, for the gift of music, and for compassion. Without love I am nothing.
to find in parent/sibling relationships these days, and for her selfless gifts which made this recording possible.
for their tireless cheer, laughter and support.
Thanks to Becky Felton for being the best soul sister (FFDDSS!).
Thanks to Lori Schultz for teaching me the importance of breathing.
the incredible feedback and spiritual guidance.
Thanks to my soul family, Lyla Akouri, Tonya Webb, and Cindy Hill. I love you all.
Thanks to John Gibbons for computer consulting and genuine friendship.
Thanks to Jammer and Garner Graber, for putting up with my late night playing, and for being wonderful roommates.
Special thanks to Max and Kathleen Haskett.
Thanks to Jewelie Hargrove, Joe Hardwick for sweet photos, Troy Deaton for our longtime friendship and your invaluable, creative engineering, Dave Pardue (my soulstice brotha), Vee Bishop (the prince of intimacy, best friend in the land of the living), Kimmie and Cassie Banner (my God-daughter),my Macintosh G4, Mark of the Unicorn, the folks at Bitheadz. and to Joseph Graste for invaluable web design help.
Special thanks to Amy Wilson for introducing me to Jeri. Jeri, I'm so grateful that all of my roads led me to you.
If I've left any of you out, please accept my most sincere apologies.
Email me and I will make sure to add you to the list!


text:
https://apnews.com/article/fires-north-carolina-e2ed480f840ae0cffdb37734be953fd4
Morning fire displaces guests at North Carolina motel
GRAHAM, N.C. (AP) — An early morning fire swept through a North Carolina motel, displacing guests and causing approximately $500,000 in damages, officials said. No injuries were reported.
Guests reported the fire in the attic at the Embers Motor Lodge at around 5 a.m. on Sunday, news outlets reported. Firefighters arrived within a minute, according to a news release from the Graham Fire Department. Firefighters reported flames in the main two-story section of the motel. Around 11:39 a.m., the fire was under control, the fire department said.
All 35 rooms were rented at the time of the fire, authorities said. The motel, built in 1955, is located adjacent to Interstate 40/85 in Alamance County.


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Leaked neo-Nazi chat room shows a movement self-destructing in real time
By Jack Smith IV
When most people think of modern neo-Nazis, they're often, without realizing it, thinking of the Traditionalist Worker Party. At the infamous Unite the Right rally in Charlottesville, members of the TWP in black helmets and Dickies work shirts formed a phalanx of white nationalists with riot shields, chanting "blood and soil" and squaring off against anti-fascists.
They were America's new face of white pride, Confederate nostalgia and far-right extremism. And now, they've collapsed entirely.
A leaked trove of server data from chat app Discord chronicles the internal life of an organization as it rose to national prominence, mismanaged its fame and ended in disgrace. The chat logs were published Thursday night by Unicorn Riot, a grassroots media collective that's published several massive troves of white nationalist communications. The collected channels contain nearly 200,000 messages from over the past year, documenting the everyday lives of disaffected young white men as they share white supremacist memes, chat about the challenges of coming out as white nationalists to family and friends, and, rightfully, worrying over whether they're being monitored by anti-fascists.
The Traditionalist Worker Party was a neo-Nazi group that regularly appeared at far right rallies, most recently holding security details for Richard Spencer at his college speaking appearances. Chip Somodevilla/Getty Images
If most Americans see the Unite the Right rally as a dark event in America's contemporary history, white nationalists largely saw it as a success for recruiting and national media exposure. The rally is still part of the divisive "optics" debate in the white nationalist community over how the movement should appear to the public for the sake of growing their movement.
Where Unite the Right might have given the movement public momentum, it was catastrophic to individuals as anti-fascists combed obsessively through photos and videos from the event to publicize the identities of everyone involved. Many participants at the rally lost their jobs for attending.
On a server called "The Silver Guild," white nationalists tried to start a small fraternal network wherein a group including a security guard, a sound engineer, a PC repair guy, someone from "a pretty racist union" in Michigan, and an insurance salesman tried to exchange advice about how to get work when your face is on the front page of every local newspaper identifying you as a celebrity racist. It was difficult for some of them to get their home enterprises, like making flags or producing sodium to sell on eBay, to sustain their lifestyles, and they traded tips on how to make it through job interviews as a known white nationalist.
"Equate your political views with quality work," one Baltimore-area neo-Nazi with video production expertise advised the group, advising him to tell employers that, "You may think a [white nationalist] is full of hate, but he will get shit done."
Matthew Heimbach, pictured above fighting anti-racist protesters in East Lansing, Michigan, was the leader of the Traditionalist Worker Party and one of the country's most prominent neo-Nazis. Scott Olson/Getty Images
Over time, a combination of internal disputes and public embarrassments has left the white nationalist movement in shambles. Richard Spencer declared that "antifa is winning" the battle in the streets and said he doesn't intend to continue his infamous campus appearances. Chris Cantwell, popularly known as the "crying Nazi" from Unite the Right, admitted publicly that he'd become an FBI informant.
And then, the Traditionalist Worker Party collapsed. On March 13, TWP leader Matthew Heimbach was arrested for allegedly assaulting both his spokesman, Matt Parrott, and his wife, who is also Parrott's step-daughter. Heimbach was having an affair with Parrott's wife, and Parrott set up a sort of sexual sting operation using his wife as bait to see if Heimbach would try to seduce her again. It's a complicated network of sexual and familial relations — we made a diagram here. Parrott resigned from the movement, telling the Southern Poverty Law Center that he was "out of the game," before deleting the TWP's website and membership rolls.
Now that the organization is officially disbanded, with Matthew Heimbach silent in the past few weeks and his adherents looking for new opportunities in a fracturing movement, it's unclear if the remaining white nationalists will rally or give up the project. In the last days of the party's existence, members speculated that perhaps the solution would be to rally behind leaders who didn't have wives or sex. Women are just too much of a vulnerability for the movement.
"This is why it's good to have a leader who's celibate," one member said in an audio chat.
"That's why I don't have a girlfriend, that's totally why," another joked in response. "I'm thinking ahead. Now my rise to power begins."


You're not just a patient at Dr. Craig's. You should think of us as your partner in your dental health. And by understanding the health concerns and procedures involved in your dental health, you can take a more active role in maintaining a healthy smile. CAESY patient education is a multimedia system that covers a wide variety of dentistry topics. By watching one to two minute presentations, you will gain a better understanding of the procedures the Dr. Craig and his dental team perform.


Emu family drinking at Kangaluna near the glamour camping or 'glamping' grounds.
There are three emu families visiting every day, now as well as lots of kangaroos.
Why choose Gawler Ranges Wilderness safaris for you outback adventure?


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Johnson & Nomvethe on Usuthu-Sundowns clash
AmaZulu FC head coach Cavin Johnson says they will have to come with their A-game when they face Mamelodi Sundowns.
Usuthu will host the Brazilians in an Absa Premiership match at the King Zwelithini Stadium in Durban on Friday
Sundowns, who were beaten 2-1 by AmaZulu in the first round encounter in Tshwane last October, are sitting at the top of the league standings.
"Sundowns is a quality team and that's why we have to come with our A-game and make sure that we keep applying pressure for the full 90 minutes. We have to stick to our game plan if we are to beat them," Johnson said.
"We want to make King Zwelithini Stadium a fortress and we are still building. It will be no different against Sundowns. We have to be mindful of Sundowns because they are a quality team. They are the best team in Africa at the moment," the 59-year-old tactician added.
"They are number one in the league and for those reasons we need to give them respect. But at the same time we want to come out on Friday night and play the best we can."
Meanwhile, Siyabonga Nomvethe, who scored during Usuthu's victory over Sundowns earlier this season, stated that only a victory will do for AmaZulu on Friday.
"We are challenging for a place in the top eight. It is a big match. We are at home and we need to get the maximum points in order to push for a top eight spot," Nomvethe said.
Usuthu are heading into this massive clash placed 10th on the league standings. They are only a point behind eighth-placed Bidvest Wits with eight games left.
"It won't be easy for both teams. The two teams need the points for different reasons. We have a lot of games left. So, it is still possible for us to finish in the top eight," the 40-year-old forward added.
"We cannot afford to relax because we still have a lot of games left. We have to take it one game at a time. Each game is a Cup final for us. We need to focus and win games so that we can move further away from the relegation zone."
Kick-off between AmaZulu and Sundowns is at 18h00.
Usuthu look to complete double over Sundowns
Johnson: Usuthu to fight hard to upset Sundowns
Johnson reflects on Usuthu-Sundowns clash
Usuthu recuperating for Sundowns clash
Johnson & Morton on Usuthu-Ubuntu Cup clash
One comment on "Johnson & Nomvethe on Usuthu-Sundowns clash"
Sihle Ndlovu says:
Usuthu is My team, after I have neglected 1 of Soweto team, after I released that, amaZulu needs me more, plz buy players now, I love AmaZulu a lot now, where can I get membership?


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Pa. State Lottery
Powerball: See the latest numbers in Monday's $180 million drawing
Updated: Nov. 15, 2021, 11:56 p.m. | Published: Nov. 15, 2021, 11:12 p.m.
By National Desk
Grab your tickets and check to see if you're a big winner! The Powerball lottery jackpot reset again after someone won nearly $700 million on Oct. 4. Could tonight be your lucky night?
Here are Monday's winning lottery numbers:
05-31-34-51-53, Powerball: 23, Power Play: 2X
Double Play winning lottery numbers:
01-06-10-52-64, Powerball: 18
The estimated Powerball jackpot is $180 million. The lump sum payment before taxes would be about $130.1 million. If there is no jackpot winner, the top prize will grow larger for the next drawing.
Powerball is held in 45 states, the District of Columbia, the U.S. Virgin Islands and Puerto Rico. The Double Play add-on feature is available for purchase in 13 lottery jurisdictions, including Pennsylvania and Michigan.
A $2 ticket gives you a one in 292.2 million chance at joining the hall of Powerball jackpot champions.
The drawings are held at 10:59 p.m. Eastern, Mondays, Wednesdays and Saturdays. The deadline to purchase tickets is 9:45 p.m.


One video shows terrified residents knotting together ropes from bed sheets and blankets to hang from their windows.
At least six people have been killed with more than 60 others rushed to hospital after a huge blaze engulfed a 24-storey block of flats in west London. Forty fire engines and around 200 firefighters have been battling to rescue residents from the inferno at Grenfell Tower in North Kensington since shortly before 1:00 GMT on 14 June. The building is still on fire with a number of people remaining unaccounted for.
The Metropolitan Police have stated they expect the number of fatalities to rise further. Commander Stuart Cundy, from the Metropolitan Police, said: "Our thoughts are with everyone involved in this truly shocking fire at Grenfell Tower".
Fire Commissioner Dany Cotton called the blaze in the Latimer Road area near Notting Hill an "unprecedented incident" and said she had never seen anything on this scale in her 29-year career. Cotton added that some firefighters have sustained minor injuries fighting the fire.
In harrowing footage published online, residents trapped inside the tower block, which contains 130 apartments, can be seen screaming for help and waving from their windows as the deadly blaze spread across the building. Firefighters can be seen to struggle to contain the inferno with thick smoke seen billowing from the burning structure and drifting across the London skyline.
Reports have emerged of people leaping from the tower to escape the fire and using the lights on their phones to signal for help.
A baby was caught by a member of the public after being dropped from Grenfell Tower as it was engulfed with flames, a witness said. Samira Lamrani said she saw a woman try to save a baby by dropping it from a window "on the ninth or 10th floor" to waiting members of the public below.
"The baby was wrapped in some sort of bedsheet blanket," she said: "And she threw the baby and as the baby came down from approximately the ninth of 10th floor, a member of the public, a gentleman, ran foward and miraculously grabbed the baby," Lamrani added.
One video shows terrified residents knotting together makeshift ropes from bed sheets and blankets to hang from their windows in order to try and escape the burning tower.
An eyewitness can be heard saying in the footage: "Can you see that rope that goes all the way to that building. Man put a rope of all his handkerchiefs and towels". The eyewitness also shouts "watch out" as large chunks of fiery debris begin to cascade from the upper floors of the tower.
People living nearby soon came out in large numbers to see the blaze and record footage of the fire. This video filmed by local resident Catherine Veliz shows dozens of onlookers watching the blaze from nearby St Clements Church in Treadgold Street. The church has now been turned turned into an evacuation centre to support those who have managed to escape the blaze.
Reverend Michael O'Donoghue, the area Dean for Kensington, said that The Grenfell Tower inferno reminded him of "that image of 9/11 where you had the blue sky and the block on fire". Speaking to IBTimes UK from St Clements Church, he described the effort to help those who had fled the burning building.
"They've been [the church members] offering people somewhere to come out of the chaos, they've been offering a shoulder to cry on and someone to chat with, pray with. They've been offering the compassion of Christ with food and drink and all sorts of things," he said.
The huge plumes of smoke thrown up by the blaze were visible for miles around. A video shot by Jamie Kirkwood from aboard a plane flying over London shows a large trail of smoke emanating from the burning tower.
In another video, eyewitnesses have criticised the response from the London Fire Brigade. "It's very chaotic, it felt like it wasn't well organised," one witness stated. "You could see just a few fire engines, not that many officers, a lot of people screaming," he added.
Another local resident added: "What upset me, the fire brigade, they were late and there was not enough engines. They were asking people to stay inside and I tried to say 'why?'".
The fire is believed to have started on the third or fourth floor soon after midnight, before quickly spreading up the building. After sending a structural engineer to assess the building, the London Fire Brigade have said that the tower is not in danger of collapsing.
London Mayor Sadiq Khan said questions need to be answered about tower blocks around the city following a devastating fire. Khan had been called to respond after reports that people had been advised in advance to remain in their flats in the event of fire. The Mayor said in a statement: "There will be a great many questions over the coming days as to the cause of this tragedy and I want to reassure Londoners that we will get all the answers".