text:
Q: Is there any way to set SendEmailAsync to isHtml= true? I am working on Forgot Password Functionality in Asp.Net MVC.
I am able to successfully send forgot password link to email thorugh SendEmailAsync Method, but email is isHtml = false.
How can I make it to true?
public Task SendAsync(IdentityMessage message)
{
   SmtpClient client = new SmtpClient();
   return client.SendMailAsync("email",
                                    message.Destination,
                                    message.Subject,
                                    message.Body);
}

A: You need to use another overload which takes a MailMessage object. For example:
SmtpClient client = new SmtpClient();
var message = new MailMessage();
message.IsBodyHtml = true;
message.Body = "email";
//Set other properties such as subject etc.
return client.SendMailAsync(message);


This is a record of Marilyn Manson's first and last performances of their material. The list is not being updated automatically and may contain very outdated information.
↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 1.13 1.14 1.15 1.16 1.17 1.18 1.19 1.20 1.21 Portions of the song were played live, but the song was not played in its entirety.
This page was last modified on 29 October 2018, at 09:49.


Business services specialist Toshiba TEC, has expanded its product portfolio to include two new A4 monochrome printing devices.
The multifunction e-STUDIO478S and e-STUDIO528P combine compact design with reliability and low running costs, making them ideal for small to medium-sized companies and workgroups. Their energy-saving design as well as their performance are key user benefits.
These versatile devices offer a wide range of paper handling capabilities that can be tailored to the user's individual needs and, with print speeds of up to 52 pages per minute, this combination of high level performance helps users to maximise productivity in their business operations. Added to that, Toshiba's long-life consumables and reliability ensure smooth operation with minimal interruptions.
Both models have mobile printing support to allow direct printing from smart phones and tablets and both feature a colour LCD touch screen user interface which is highly intuitive in operation: all of the system's functions can be accessed with a swipe and a touch of a finger.
As with all of Toshiba's multifunction ranges, these new models adhere to its low carbon footprint procedures, which minimise the environmental impact throughout the lifecycle of the device. In addition, any emissions produced as part of the procurement, manufacturing, and delivery processes are offset so the device is 'Carbon Zero' which allows for positive business activities with no detrimental effect on the environment.


Graphic colours, a cute print and super soft fabric – our statement Panda Knit has got it all. This irresistible sweater also features a split hi-lo hem, ribbed cuffs, striped sleeves and a contrast black neckline. Pair this cosy knit with black jeans and boots for a casual cool look, or with our statement Cobra Pant for the ultimate fashion outfit.


The Flourishing Children Project is part of a major initiative by Child Trends to develop rigorous national (US) indicators of flourishing among children and youth for inclusion in national surveys, research studies, and program evaluations. This work was conceptualized and implemented following the 2003 Indicators of Positive Development Conference, which brought together federal officials, foundation staff members, and researchers to consider indicators of positive development ranging from health behaviors, religiosity, frugality, and parent-child relationships.
This site includes information on the project, construct definitions, measures, and psychometric testing results, links to a webinar and presentations, as well as links to a book, Flourishing Children: Defining and Testing Indicators of Positive Development, which presents the results of the Flourishing Children Project, and is available for purchase.


Rearing an orphan animal is a costly and long-term commitment.
Two tiny warthog piglets were found wandering around the golf course of Elephant Hills Resort, just outside the town of Victoria Falls. The piglets were but a few days old, with their mother nowhere to be seen. Temperatures skyrocket during the hot months herer, and the piglets were unable to go very long without milk. The disarming duo stole Doreen Posselt's heart. This Victoria Falls Wildlife Trust volunteer has taken care of many orphaned animals before, and so she yet again volunteered to rear the piglets. The little hogs, who initially suffered from a bacterial infection, needed to be fed every two hours. The infection cleared up, and the two baby boars grew strong quickly. Once the two warthogs were weaned and self sustainable they were translocated to the Wild Horizons Wildlife Orphanage and Sanctuary where they were released. Initially the two pigs hung around human areas, and near the elephant. However, over time they grew in confidence and soon left the human areas to be on their own back in the wild.
On Saturday July 12, 2008 our precious baby elephant Chizi stopped breathing at 3am. We would like to thank all of you that have helped us try our very best to raise Chizi for the past 18 months. She was truly extraordinary and touched each of our lives in very special ways. We will all miss her dearly and never forget the memories she imprinted in our minds. For those of you that want a bit of history, please click here.


text:
Customs Committee
Summer 2017 Market Update
by AIIS Staff | Jul 14, 2017 | Blog, Newsletters | 0 comments
The economy did not start off 2017 quite as slowly as initially estimated.
The Bureau of Economic Analysis (BEA) in June revised its measure of growth in the first quarter to an annualized rate of 1.4 percent, up from the 0.7 percent that the agency announced in April and the 1.2 percent estimate of gross domestic product (GDP) growth in May. Despite the change, the BEA noted that "the general picture of economic growth remains the same." The economy grew by 2.1 percent during the fourth quarter of 2016. "The deceleration in real GDP in the first quarter reflected a downturn in private inventory investment, a deceleration in [personal consumption expenditures], and a downturn in state and local government spending that were partly offset by an upturn in exports, an acceleration in nonresidential fixed investment, and a deceleration in imports," the BEA stated. Consumer spending typically drives growth, accounting for about 70 percent of all economic activity, and consumers did not do much driving from January to March. Spending increased by just 1.1 percent during the first quarter, according to the BEA, the worst performance since Q2 of 2013, but much better than the 0.3 percent growth that the agency initially estimated. Analysts are expecting a better second quarter, with some forecasting growth of as much as 3 percent. If this is to happen, consumers will have to boost their spending. After shrinking by a non-annualized rate of 0.3 percent in January and being flat in February, consumer spending, according to the BEA, jumped 0.6 percent in March before growth slowed to 0.2 percent in April and 0.1 percent in May.
The Conference Board's Consumer Confidence Index, which had stood at 124.9 in March fell to 117.6 in May before climbing to 118.9 in June. (The index's baseline is 100 in 1985.) "Overall, consumers anticipate the economy will continue expanding in the months ahead, but they do not foresee the pace of growth accelerating," the board's director of economic indicators said.
The University of Michigan's Index of Consumer Sentiment dipped from 97.1 in May to 95.1 in June, with researchers noting that, "Although consumer confidence slipped to its lowest level since Trump was elected, the overall level still remains quite favorable." The index breaks down results by party affiliation, and it has regularly noted a stark "partisan divide" in consumer sentiment.
"Surprisingly, the optimism among Republicans and Independents has largely resisted declines in the past several months despite the decreased likelihood that Trump's agenda will be passed in 2017," researchers stated. "The most important policies to consumers are those that directly or indirectly affect their jobs, incomes, or their financial security. Fortunately, increasing uncertainty about future prospects for the economy has thus far been offset by the resurgent strength in the personal financial situation of consumers."
In the manufacturing sector, confidence improved significantly from May to June, with the Institute for Supply Management's Purchasing Managers Index increasing almost 3 points to 57.8 to reach its highest level in the past year. (An index over 50 indicates growth in the sector.) Of 18 industries surveyed, 15 reported growth.
"Comments from the panel generally reflect expanding business conditions; with new orders, production, employment, backlog and exports all growing in June compared to May and with supplier deliveries and inventories struggling to keep up with the production pace," the chairman of the institute's Manufacturing Business Survey Committee said.
Job growth in June came in above expectations, with 220,000 positions created, but the unemployment rate still inched up to 4.4 percent after reaching a 16-year-low of 4.3 percent in May. The labor force participation rate rose a tenth of a point to 62.8 percent in June. Ten years ago, the rate was around 66 percent, but it has dipped fairly steadily during the past decade because of both economic and structural factors – such as the retirement of baby boomers – and it has been mostly below 63 percent since late 2013.
As an analyst at Bankrate.com commented, "Once again, the buzz kill on the jobs report is the lack of more substantial wage growth." The Federal Reserve Bank of Atlanta reported that wages increased at an annualized rate of 3.4 percent in May, better than the 2010-2013 period, when the monthly rate never surpassed 2.4 percent, but still well below pre-Great Recession levels.
Despite the economic indicators not being all positive, the Federal Reserve Federal Open Market Committee, at its June 13-14 meeting, increased the target range for the federal funds rate a quarter-point to 1 to 1.25 percent. This marked the second time this year – and the fourth time since the recession – that the Fed has raised rates.
"Information received since the Federal Open Market Committee met in May indicates that the labor market has continued to strengthen and that economic activity has been rising moderately so far this year," the Fed stated in announcing the rate hike. "Job gains have moderated but have been solid, on average, since the beginning of the year, and the unemployment rate has declined. Household spending has picked up in recent months, and business fixed investment has continued to expand."
Housing starts in May fell 5.5 percent from April and were 2.4 percent below the May 2016 level, according to the Census Bureau and the Department of Housing and Urban Development. Existing home sales, meanwhile, increased 1.1 percent from April to May after falling 2.3 percent the previous month.
"The job market in most of the country is healthy and the recent downward trend in mortgage rates continues to keep buyer interest at a robust level," the association's chief economist said.
Car sales have decreased sharply from last year, with June sales 13.2 percent below a year earlier and year-to-date sales down 11.4 percent compared to 2016, Motor Intelligence reported. Light-duty truck sales, however, were 4.2 percent higher in May than they were in May 2016, while year-to-date sales increased 4.6 percent.
The dollar remains strong, and it ended June trading at 0.88 euros, 0.77 pounds, 112.36 yen and 6.8 yuan.
The Dow Jones Industrial Average, which hovered around the 21,000 mark from March through May, after rising 15 percent from Election Day until then, reached 21,349.63 on June 30. The S&P 500 Index closed June at 2,423.41.
Trump on June 1 referred to the United States as having made "absolutely tremendous economic progress since Election Day. The economy is starting to come back, and very, very rapidly." Even coming from a marketer known for using hyperbole, describing 1.4 percent growth as "very, very rapid" can only be met with incredulity. Trump was elected, at least in part, to bring a businessman's touch to the White House and to push for pro-growth policies. Tax reform, for example, could, indeed, be "absolutely tremendous" for the economy, but Trump has been burning energy and, more importantly, political capital by creating or exacerbating controversies, and this lack of focus will only make an already difficult legislative challenge even tougher. The mandate he claimed in January withers away a little more with each ill-advised tweet. Further, as was evident during July's G20 Summit in Germany, his preferred trade policies will alienate the nation's trading partners to the point of making strong economic growth essentially impossible to achieve. The protectionism that Trump favors could only work if domestic substitutes were available at the same price and quality as imported goods and if other countries declined to implement retaliatory measures. Needless to say, neither of these conditions would be true. It is understandable that many Americans without a background in macroeconomics fail to see the long-term negative effects of moving the country away from free trade, but it is unacceptable for a president – particularly one who literally wrote the book on business – to be so economically naïve.
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AIIS Newsletter: September 2019
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redpajama_set_name: RedPajamaCommonCrawl


text:
Why Altigen?
Stock Quote / Charts
OTCQB Filings
SIPTOS
Teams Phone System
Omni-Channel Contact Center
MaxCS Hosted PBX
Altigen Blog
Jeremiah Fleming, Altigen's Chief Executive Officer has been with Altigen since April 2007. Mr. Fleming has 25+ years of experience in the software and communications industries, primarily with smaller fast-growing companies, and has a strong background in sales, marketing and business development. Prior to joining Altigen, Mr. Fleming was at Interactive Intelligence, Inc. where he served in an executive management capacity for the past ten years, including international responsibilities, culminating in his role as president of the Vonexus subsidiary launched in 2004. Prior to that, Mr. Fleming spent five years at Software Artistry in various management positions, including Vice President, Domestic Sales, and 5 years at Computer Associates in various sales and sales management capacities. Mr. Fleming holds both B.A and M.B.A. degrees from the University of Missouri.
Mike Plumer is Altigen's Vice President of Sales joined Altigen in 1996, serving in numerous positions of increasing management responsibility, ultimately being promoted to Vice President of Sales in 2000. In his role, Mr. Plumer is responsible for all direct and channel sales activities worldwide. Mr. Plumer has been instrumental in developing Altigen's sales channel and in leading the company's new direct sales initiative into mid-market and enterprise accounts. Prior to serving as VP of Sales, Mr. Plumer held the positions of Senior Director of National Sales and Eastern Regional Manager. Mr. Plumer holds a bachelor's degree in Journalism and Public Relations from Iowa State University.
Shirley Sun is the Vice President of Research and Development for Altigen. Prior to her role, Ms. Sun was the Director of IP Telephony for Altigen. She has also held a management position in software development for a remote server access product line at 3Com Corp. Before her role at 3Com, Ms. Sun was the cofounder and Engineering Manager for Centrum Communications, Inc. Ms. Sun was a key contributor to the design, architecture, and building of the remote access server product from the ground up. She has also held technical positions Novell and Vitalink Communications. Ms. Sun earned her MS in Computer Science from Utah State University and a BS in Mechanical Engineering from National Central University in Taiwan.
Paul Fullman is Altigen's Vice President Skype for Business Solutions. He joined Altigen in 2011 to head up business operations in EMEA. Having a strong technical background with a number of Microsoft Specialist Qualifications, Mr. Fullman is focused on driving Altigen's Skype for Business portfolio across EMEA. Prior to joining Altigen, Mr. Fullman held a number of director positions at Datasharp UK Ltd., and is also a former Lecturer at Plymouth University, teaching Computer Systems and Network Degree Level Courses. Mr. Fullman earned a Bachelor of Arts degree in Multimedia Computing and holds a number of Microsoft Certifications including MCP, MCSE, and MCSE + I.
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text:
Aluminum adjuvant in vaccines – let's go cherry picking
With the success of California's vaccination law, SB277, there appears to be a trend to increase vaccination uptake among school-aged children. And it's a great thing that we protect our children from vaccine preventable diseases. Yet, the anti-vaccine crowd is still looking for lame excuses to not vaccinate – today, it's the aluminum adjuvant in vaccines.
The anti-vaccine crowd has a tendency to ignore the vast and powerful scientific consensus on vaccines. Instead, they prefer to cherry pick research, often from biased "scientists" who publish in the lowest quality journals. That cherry picking is a form of confirmation bias – the individual seeks evidence that supports their a priori conclusions rather than letting the robust body of evidence point them to a conclusion.
Generally, these myths, based on cherry picking, are debunked. But the anti-vaccine cult is nothing if not creative. They just move on to a new boogeyman. This time, it's aluminum adjuvants in vaccines. To be honest, anti-vaccine tropes are zombies, so we think we destroy those tropes, but they rise again, fed by new cherry picking. And debunking the danger of aluminum in vaccines has been an age-old discussion amongst the pro-science crowd.
Today, we're going to look at one of those articles which was recently published. If one accepted this research, while ignoring critical analysis and the body of other science, then it would be a great one to confirm one's own pre-conceived beliefs. But that's not how we do science, so let's take a look.
New aluminum adjuvant article
Who? What? Where?
Aluminum adjuvant research
The TL;DR version
Key citations
The article, "Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations" (full article) by Mold, Shardlow and Exley, was recently published in Scientific Reports. It's a complex and photo-filled article, but that doesn't mean it gets a pass on a critical examination. We'll do that below.
But here's the key point the researchers make:
We demonstrate that not all aluminium adjuvants are equal neither in terms of their physical properties nor their biological reactivity and potential toxicities both at the injection site and beyond. High loading of aluminium oxyhydroxide in the cytoplasm of THP-1 cells without immediate cytotoxicity might predispose this form of aluminium adjuvant to its subsequent transport throughout the body including access to the brain.
That's essentially the authors' conclusion. And if you were cherry picking and quote mining to "prove" vaccines are root of all evil, then you'd jump on this article.
You might ask, why have an aluminum adjuvant in vaccines? An adjuvant is a component of vaccines that increases the immune response to an antigen. Aluminum phosphate and aluminum hydroxide are the most common forms of adjuvants used in commercial vaccines. So that's why – it makes the immune response better.
But, let's take a critical look at this paper and the research behind it. Because there's more here than what meets the eye.
I'm going to look at this article in two ways. First, I'm going to look at the meta – no not a meta-review or analysis, but what's behind the article. And second, we'll look at the science.
Let me start with one key point – this article was published in a relatively high impact factor journal (5.228), Scientific Reports. The journal is owned by Nature, one of the most respected and high impact factor journals in science. Frankly, once I knew it was published in a Nature owned journal, I was thinking that this was going to be some good science. I fell for a trap.
Scientific Reports is an open-source, fast publication, peer-reviewed journal. It was probably launched to compete with popular open-sourced journals, like PLOS. Being fast or open-sourced does not mean it's bad, but it does mean that some bad research can sneak through the cracks.
But there are some other points that need to be addressed. The authors are in residence at the Lennard-Jones Centre, a UK-based research foundation that focuses on physics, quantum mechanics and chemistry.
However, as far as I can tell, there isn't a single researcher with significant credentials in immunology, neurobiology, or almost any important aspect of vaccine research. This lack knowledge of basic biomedical science seems to be apparent in the article. Now, one does not have to be a biologist to become a great biologist – but if you're going to publish a paper that condemns one of the basic principles of vaccines, I want to see researchers who actually are experts in vaccines.
Admittedly, the three authors seem to have a lot of published research in environmental aluminum – that's a key point. They seem to have an obsession with aluminum toxicity and Alzheimer's disease – something that has been utterly dismissed by the scientific community.
In fact, the Alzheimer's Society does not mention aluminum once in their discussion of risk factors for dementia. Maybe Big Aluminum is in control.
The reason why aluminum isn't linked to neurological disease is that in huge epidemiological studies, no correlation was found between environmental aluminum and neurological diseases. None. The authors seem to ignore the wealth of evidence that dismisses their research. And I think there might be reasons for that.
The most issue regarding their research, and a troubling concern for anyone with a scientific neuron or two, is that this study was funded by the Dwoskin Family Foundation. This foundation is one of the most profoundly anti-vaccine sponsors of research in the world.
Dwoskin has funded research by two of the biggest quacks in the vaccine community – Christopher Shaw and Lucija Tomljenovic. Their "research" (scare quotes intentional) is often laughably biased and is nearly always published in junk science predatory journals. They actually did publish an article in a respected journal – it was retracted.
Claire Dwoskin is a board member of the anti-vaccine group National Vaccination Information Center. In 2011, the Dwoskins also underwrote the anti-vaccine "safety" conference in Jamaica, which included as speakers, the quacks Shaw and Tomljenovic.
I do think that the funding source should be given some weight in determining the bias of research. Even the anti-vaccine cult agrees, because read just about anything they write in which they automatically dismiss anyone or any research that even has a tenuous tie to Big Pharma.
But the Dwoskins are just so anti-vaccine, it's difficult for me to overlook the funding of this research. I have found no indication that they give grants to any studies that are not supportive of any of the important tropes of the anti-vaccine movement.
Basically, when I saw their name as one of the sources of money, I was about 10 nanoseconds from dismissing this research as utterly useless. Now, it's possible that the researchers here don't know who the Dwoskins are, but that would be almost impossible to embrace. Without any evidence whatsoever, I think that the researchers saw where their research was going and knew that they could get some dollars out of the Dwoskins.
But enough with these criticisms. Let's look at the science.
Like I mentioned previously, this article is thick with data. To critique each point that I find difficult to accept would force me to write a 5000 word article. I'm going to stick with the points that cause me the most trouble, in a bullet point fashion. This list is not in any particular order – it's not ordered in any particular way.
In vitro research. As I've written before, studies in cell cultures can lead to scientific breakthroughs – and this study utilizes a hum cell culture line. However, less than 1% of cell culture studies ever lead to clinically meaningful results. There are lots of reasons for this lack of results – mostly because cell cultures are a "model" for biological effects, but it's extremely limited. Call me in 20 years if there's some case-control epidemiological studies that support this research.
The THP-1 cell line. This cell line is derived from the blood of a human male with acute monocytic leukemia. It is generally used in examining leukemia protein-protein interactions, and for immunohistochemistry, a field that attempts to detect antigens in cells of a tissue sections under microscopy. This is sort of the research that the authors are doing, but it's an unusual application.
Cell lines ignore physiology. This drives me crazy about cell culture research. Cells are grown in an artificial medium that generally feeds the cell – but that's not how real cellular physiology works. For example, the body has methods to flush environmental aluminum out of the body – including secretion into urine and bile.
Concentration of aluminum adjuvant. The researchers used 2.5, 25.0, 50.0 or 100.0 μg/mL of vaccine adjuvants. Most vaccines contain about 125 to 800 μg of aluminum adjuvant, which may appear to be close to what we see in this research. However, if we look at the aluminum concentration in the body after injection, these doses are equivalent to around 0.125 to 0.8 µg/ml (assuming a 12 kg baby), orders of magnitude lower than what was used in this research. One could argue that the concentration is higher at the injection site, but this research uses blood cells, not muscle cells. I can only conclude that these researchers were using higher concentrations of aluminum adjuvant to get more clear results. I don't mind this, but the authors should explain why they went so high.
Results. I'm going to admit that my scientific background lacks histology – it was boring to me. But, I've got enough knowledge to unequivocally state that I don't get their results and subsequent conclusions. They published nice electron micrographs that show big aluminum globs (my scientific terminology) in some cells. I don't know what percentage of cells include these globs, because they didn't have a control against which to compare. But here are some of the issues – there is no explanation of what are biological consequences of these globs, and no explanation if this representative of what may be the clinical application in real humans. Moreover, it is problematic that the lowest concentration of adjuvant used, 2.5 µg/ml which is 2-10X higher than the blood concentration immediately post-vaccination, showed no globs. They are using much higher concentrations of adjuvant to get results, and even then, a real human body would deal with it quickly by dilution and secretion.
Citations. Generally, I don't care about what's cited. But to quote the authors, "Furthermore, the use of adjuvants in human vaccinations has been linked to adverse effects often classified under Autoimmune (or autoinflammatory) syndrome induced by adjuvants (ASIA)." No it hasn't. The authors are citing two articles from the aforementioned quacks, Shaw and Tomljenovic, plus another article from one of the most notorious anti-vaccination "scientists" in the world, Yehuda Schoenfeld, who invented "ASIA," a concept that has been dismissed scientifically. It's difficult, if not impossible, to accept this research when they uncritically accept the ridiculed and debunked "evidence" invented by ridiculed and debunked researchers.
When I was shown this article, I was open-minded. I thought that it would be interesting to see if there are neurological effects from aluminum, because there's been a "debate" about aluminum and dementia, despite the lack of evidence that there is a link.
But once I reviewed this article I was struck by these key points:
Monetary support from the anti-vaccination crowd.
Citing discredited published research and researchers as if they are respected.
Providing observations with no biologically plausible consequences from them.
Questionable methodology.
I admit, I am biased toward epidemiological studies that have p values and risk ratios. I want to see numbers. But subjective observations of globs? It tells us nothing about any aluminum adjuvant, so we stick with the default position supported by mountains of evidence – adjuvants are safe.
If I were to make a recommendation to anyone who is confronted by this article – laugh first, and point out the flaws.
Inbar R, Weiss R, Tomljenovic L, Arango MT, Deri Y, Shaw CA, Chapman J, Blank M, Shoenfeld Y. WITHDRAWN: Behavioral abnormalities in young female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil. Vaccine. 2016 Jan 9. pii: S0264-410X(16)00016-5. doi: 10.1016/j.vaccine.2015.12.067. [Epub ahead of print] PubMed PMID: 26778424.
Mold M, Shardlow E, Exley C. Insight into the cellular fate and toxicity of aluminium adjuvants used in clinically approved human vaccinations. Sci Rep. 2016 Aug 12;6:31578. doi: 10.1038/srep31578. PubMed PMID: 27515230.
Santibáñez M, Bolumar F, García AM. Occupational risk factors in Alzheimer's disease: a review assessing the quality of published epidemiological studies. Occup Environ Med. 2007 Nov;64(11):723-32. Epub 2007 May 24. Review. PubMed PMID: 17525096; PubMed Central PMCID: PMC2078415.
Shaw CA, Petrik MS. Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration. J Inorg Biochem. 2009 Nov;103(11):1555-62. doi: 10.1016/j.jinorgbio.2009.05.019. Epub 2009 Aug 20. PubMed PMID: 19740540; PubMed Central PMCID: PMC2819810.
Shoenfeld Y, Agmon-Levin N. 'ASIA' – autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. 2011 Feb;36(1):4-8. doi: 10.1016/j.jaut.2010.07.003. Epub 2010 Aug 13. Review. PubMed PMID: 20708902.
Tomljenovic L, Shaw CA. Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations. Lupus. 2012 Feb;21(2):223-30. doi: 10.1177/0961203311430221. PubMed PMID: 22235057.
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CategoriesVaccines Tagsadjuvants, aluminum, Alzheimer's disease, Autoimmune syndrome induced by adjuvants, Christopher Shaw, Dwoskin Family Foundation, Lennard-Jones Centre, Lucija Tomljenovic, Yehuda Shoenfeld
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"Osteoporosis" literally means "porous bones." The bones become weaker, increasing the risk of fractures, especially in the hip, spinal vertebrae, and wrist. Bone tissue is constantly being renewed, and new bone replaces old, damaged bone. In this way, the body maintains bone density and the integrity of its crystals and structure. Bone density peaks when a person is in their late 20s. After the age of around 35 years, bone starts to become weaker. As we age, bone breaks down faster than it builds. If this happens excessively, osteoporosis results.
Bisphosphonates: These are antiresorptive drugs that slow bone loss and reduce fracture risk.
Estrogen agonists or antagonists, also known as selective estrogen-receptor modulators, SERMS), for example, raloxifene.
(Evista): These can reduce the risk of spine fractures in women after menopause.
Calcitonin (Calcimar, Miacalcin): This helps prevent spinal fracture in postmenopausal women, and it can help manage pain if a fracture occurs.
Parathyroid hormone, for example, teriparatide (Forteo): This is approved for people with a high risk of fracture, as it stimulates bone formation.
RANK ligand (RANKL) inhibitors, such as denosumab (Xgeva): This is an immune therapy and a new type of osteoporosis treatment.
Other types of estrogen and hormone therapy may help.
In the future, treatment may include stem cell therapy. In 2016, researchers found that injecting a particular kind of stem cell into mice reversed osteoporosis and bone loss in a way that could, potentially, benefit humans too.
Findings published in 2015 suggested that growth hormone (GH) taken with calcium and vitamin D supplements could reduce the risk of fractures in the long term.
Also in 2015, researchers in the United Kingdom (U.K.) found evidence that a diet containing soy protein and isoflavones may offer protection from bone loss and osteoporosis during menopause. Scientists believe that up to 75 percent of a person's bone mineral density is determined by genetic factors. Researchers are investigating which genes are responsible for bone formation and loss, in the hope that this might offer new ways of preventing osteoporosis in the future.


text:
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redpajama_set_name: RedPajamaGithub


text:
Attorney Scott P. Kessler
Managing Shareholder
1-800-TEAMLAW
Scott Kessler specializes in Workers' Compensation and Personal Injury matters, including Motor Vehicle Accidents, Truck Accidents, Dog Bites and Slip and Fall accidents. Mr. Kessler was for many years Certified by the Supreme Court of New Jersey as a Workers' Compensation Attorney, a specialty designation earned by only 1/10 of one percent of all New Jersey lawyers.
Mr. Kessler's name has frequently appeared on the annual "Super Lawyers" list published in New Jersey Monthly Magazine. Appearing in the New Jersey Supreme Court, he successfully fought to establish new legal precedents and expand the rights of injured workers in the Supreme Court case of Sager vs. O. A. Peterson Construction Co. He was the Acting Municipal Prosecutor for Freehold Borough from 1990 – 1991, and was the Managing Attorney of the Team Law Workers' Compensation Department from 1991 – 2011.
Mr. Kessler graduated from Rutgers University with a Bachelor of Arts degree in 1980, and received his Juris Doctor degree from New York Law School in 1988. He became licensed to practice law in the State of New Jersey and the United States District Court, District of New Jersey, in 1988. He has been a Vice-President of The New Jersey Advisory Council on Safety and Health, a workers' rights advocacy group, since 2008, and is a member of the New Jersey State Bar Association.
State Court Admissions
New Jersey 1988
Certified by the Supreme Court of New Jersey as a Workers' Compensation Attorney
Federal Court Admissions
U.S. District Court of New Jersey 1988
Recognized as Super Lawyer in the New Jersey Monthly Magazine from 2006 – 2010 and 2012 – 2015
Certified by the Supreme Court of New Jersey as a Workers' Compensation Attorney, a specialty designation earned by only 1/10 of 1% of all New Jersey lawyers
New York Law School, J.D. 1988
Rutgers University, B.A. 1980
Member of the New Jersey State Bar Association
Vice-President and Member of the New Jersey Advisory Council on Safety and Health


Wuskwi Sipihk School held its annual art fair last Friday March 22, 2019. Check out the photos in our gallery to see all the great artwork that was for sale! They hosted a feast, a powwow demonstration and teaching, sang, and drummed for the attendees. All the proceeds from the art sales went directly to the students.
This entry was posted in Blog, Culture & Language, Education, Events, First Nations, General, News & Issues, What's New. Bookmark the permalink. Both comments and trackbacks are currently closed.


text:
/*
 * Do not modify this file. This file is generated from the devicefarm-2015-06-23.normal.json service model.
 */
using System;
using System.Collections.Generic;
using System.Xml.Serialization;
using System.Text;
using System.IO;

using Amazon.Runtime;
using Amazon.Runtime.Internal;

namespace Amazon.DeviceFarm.Model
{
    /// <summary>
    /// Represents the result of a create upload request.
    /// </summary>
    public partial class CreateUploadResponse : AmazonWebServiceResponse
    {
        private Upload _upload;

        /// <summary>
        /// Gets and sets the property Upload.
        /// <para>
        /// The newly created upload.
        /// </para>
        /// </summary>
        public Upload Upload
        {
            get { return this._upload; }
            set { this._upload = value; }
        }

        // Check to see if Upload property is set
        internal bool IsSetUpload()
        {
            return this._upload != null;
        }

    }
}


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Anti aging research
Mitochondrial transfer technology
Anticancer vaccine research
Autoimmune and Allergic Disorders Immunotherapy
Chronic Inflammatory Diseases Immunotherapy
OPI Therapy for Motor and Skin Diseases
Storage of Immune Cells
R&D Products
Cord blood plasma
Polyantigenic anticancer vaccine
Cell-based Products
Older women who suffer from tooth loss are more likely to develop high blood pressure
Related Science News
Postmenopausal women who have experienced loss of all teeth are at higher risk of developing high blood pressure, according to a University at Buffalo study published Dec. 4 in the American Journal of Hypertension.
Multiple studies have suggested an association between periodontal disease and tooth loss with hypertension, but the relationship with time remains unclear with these associations.
Study participants were 36,692 postmenopausal U.S. women from the Women's Health Initiative-Observational Study. Participants were followed annually from initial periodontal assessment in 1998 through 2015 for newly diagnosed hypertension.
Senior lady. Image credit: pxhere.com, CC0 Public Domain
The study observed a positive association between the loss of all teeth and hypertension risk among postmenopausal women. Specifically, these women had approximately 20 percent higher risk of developing hypertension during follow-up compared to women who still had natural teeth. The association was stronger among younger women and those with lower body mass index.
"We are continuing to explore the underlying reasons for the association between tooth loss and hypertension. Future studies on the impact of tooth loss on dietary patterns, inflammation, and the communities of bacteria that live in the mouth may give us further insight into this association," said Joshua H. Gordon, the paper's lead author.
Gordon is a graduate student in the MD/PhD Medical Scientist Training Program offered between the School of Public Health and Health Professions (SPHHP) and the Jacobs School of Medicine and Biomedical Sciences at UB.
There are several possible reasons for the observed association. One theory is that tooth loss could lead to changes in dietary patterns that could be associated with higher risk of hypertension. There was no association found between periodontal disease and hypertension.
The study suggests that older women who have lost their teeth may represent a group with higher risk for developing hypertension. As such, the researchers involved in the study believe that improved dental hygiene among those at risk for tooth loss as well as preventive measures such as closer blood pressure monitoring, dietary modification, physical activity, and weight loss may reduce the risk of hypertension.
The findings also suggest that tooth loss may serve as a clinical warning sign for increased hypertension risk.
"These findings suggest tooth loss may be an important factor in the development of hypertension," said the paper's senior author, Jean Wactawski-Wende, dean of UB's School of Public Health and Health Professions. "Further research may help us to determine the underlying mechanisms by which these two common diseases are associated."
Source: State University of New York at Buffalo
UNH Researchers Discover New Inhibitor Drug Combination for Rare Form of Cancer
Moonshots for the Treatment of Aging: Less Incrementalism, More Ambition
Artificial intelligence tool for reading MRI scans could transform prostate cancer surgery and treatment
Tackling rare genetic diseases with own genome editing technology
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Bruce Peninsula National Park is located just outside the Town of Tobermory and was founded in 1987. It is a unique place within the borders of Ontario and it is within easy distance from most of the major tourist destinations.
Located in the center of a UNESCO World Biosphere Reserve the park contains incredible scenery, rare flora and fauna, a diverse collection of wildlife and activities to please a wide array of interests with some amazing vistas to view either the sunrise or sunset.
Situated on the northern tip of the Bruce Peninsula, between Georgian Bay and Lake Huron the park is 155 square kilometers in size and comprises the largest remaining chunk of natural habitat in southern Ontario.
On the east coast of this peninsula, Bruce Peninsula National Park is bounded by the Niagara Escarpment which drops off into Georgian Bay. To the west you'll find fabulous beaches along the shores of Lake Huron. To the north and surrounding the park is another of Canada's National Parks: Fathom Five National Marine Park, one of the best diving sites in the world.
The park is comprised of a variety of distinct habitats ranging from the rugged cliffs of the Niagara Escarpment to flat, dry rock plains called alvars, to various types of swampy wetlands. Many of these are separated by sections of privately owned land.
The cliff-edge ecosystem contains ancient Eastern White Cedar trees, some upwards of 850 years old. A dead 1845-year-old cedar was found on Flowerpot Island. It had died about 1500 years ago was only 1.5 metres (5 ft.) tall! This fragile ecosystem survives due to its remote proximity and the fact that the cliffs aren't the best place to grow but they're one of the safest places to live. There are no forest fires, nor logging and very little impact by humans.
In addition to the cedars, the park also contains a variety of rare plants including 43 species of orchids, rare ferns and ½ the world's supply of dwarf lake iris.
Insider Tip: Black bears are present but they tend to avoid human contact. They are however strongly attracted to human food and garbage and will lose their inclination to avoid after become accustomed to eating our garbage and carelessly stored food. These bears can become a serious problem as they are quite large and can easily cause serious injury including death. Never approach a bear and avoid at all times.
Insider Tip: The Eastern Massasauga rattlesnake is a very endangered species and is now reduced to a few scattered populations. You will more than likely never encounter this snake but it is better to be safe than sorry when hiking through the park. Protect yourself and always wear longer pants with thick socks and hiking boots and always kkep aware of where you are putting both your hands and feet. If you do happen to encounter a snake, report it to the park office.
Entry fees to the park also include entrance to Fathom Five National Marine Park and Flowerpot Island. Parking, camping and diving fees are not included and are sold separately.
As soon as you arrive at the Bruce Peninsula National Park visitors center you can't help but notice the tall observation tower. At 65 ft (20 meters) tall it has 112 steps and offers amazing panoramic views over the area. If you are physically able be sure to climb to the top and check out the views. You will be impressed. This is something you definitely will not want to miss.
Cyprus Lake Trail - 5 kilometres (3 miles) long it takes about 2.5 hours. The trail loops around Cypress Lakeand is low in difficulty. It is accessed from the Head of Trails.
Georgian Bay - Marr Lake Trail - 3 kilometres (1.8 miles) long it takes about 3.0 hours. It reaches out to the bay then loops back to the Head of Trails. The difficulty varies and it is accessed from the Head of Trails. Halfway Point Rock offers an excellent vista with Flowerpot Island off in the distance. The trail also passes by Indian Head Cove which is an excellent diving and swimming spot. Further along are two sea caves, a natural arch and the famous Grotto.
Horse Lake Trail - 1 kilometre (.6 miles) in length it takes about 0.5 hours. It traverses long the shore of Horse Lake and is of moderate difficulty. Also accessed from the Head of Trails.
Singing Sands - 1.5 kilometres (1 mile) in length it takes about 0.5 hours as it is of low difficulty. The trail is on the west side of the Peninsula in a separate isolated section of the park across the highway from George Lake. It is well know for its orchids.
Halfway Log Dump - Is accessible from Emmett Lake via the gated road. This 3 kilometre (1.8 mile) hike will take you to one of the most spectacular areas of the Escarpment that lies within the park. Of moderate difficulty it takes about 1.5 hours.
Bruce Peninsula National Park is connected to the 800-kilometer Bruce Trail which provides a journey on its own for avid long term hikers and backpackers. Be sure to check out my Bruce Trail page for more information.
Front Country Camping - Bruce Peninsula National Park has 242 campsites in the area of Cyprus Lake. Tamarack (best for tent camping) has 81 sites, Birches 98 sites and Poplars 63 sites. There are no serviced sites available in the park. There are basic amenities but no showers. Showers are available for a fee just outside the park and in Tobermory. The park gets extremely busy and reservations are strongly recommended during high season. The Bruce Trail in this area is spectacular, especially further along near the Lion's Head area.
Group Camping - There are three group camping sites at Cypress Lake. The sites have basic facilities only. Groups must qualify top utilize, contact the park for more information.
Backcountry Camping - There are wilderness camping sites in the park along the Bruce Trail following the Niagara Escarpment at High Dump and Stormhaven. There are 18 sites in total and access to the sites is along a rather rugged trail. You must pre-register to obtain one but reservations will prevent you from being. There is also a camping area on Flowerpot Island in Fathom Five National Marine Park located just off Tobermory. See my Fathom Five National Park page for more details.
Canoeing is available along the park's shores but open canoes are not recommended as these waters are cold and very unpredictable.
Bruce Peninsula National Park and its neighbor Fathom Five National Marine Reserve provide a sea kayaker's paradise. Whether a first timer or a long time veteran the area provides some of the best inland sea kayaking in the world.
Beautiful scenery like sheer limestone cliffs abound, enchanting destinations like Flowerpot Island and the Grotto are lapped by waters varying in color from emerald green to deep blue. Paddle among shipwrecks lying just a few feet underwater. This is an activity that I highly recommend as you will have access to sites you simply can't see from shore.
Insider Tip: This can be a dangerous activity for newbie's and experienced kayakers alike. The weather can be highly unpredictable and can change suddenly. The water is extremely cold and hypothermia can easily set in. Make sure you check the weather report before heading out and NEVER go out alone.
See my Fathom Five National Marine Park page for information on the area's world-class scuba diving activities.


people of the Commonwealth. We have one goal to make it easy for you to find what you need. This fall, we'll continue to. RI Orangevale Department of Labor and Training Unemployment Insurance Unemployment Insurance UI provides temporary and partial wage replacement to workers who have become unemployed through no fault of their own. Google Search the West-Stockbridge world s information, including webpages, images, videos and more. Google has many special features to help you find exactly what you re looking for.


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McPherson Square Library
Public Transportation Directions to McPherson Square Library
601 East Indiana Avenue
Indiana Ave. & "F" St.
Sunday, 1/22 Closed
Monday, 1/23 10:00 a.m. – 6:00 p.m.
Tuesday, 1/24 10:00 a.m. – 6:00 p.m.
Wednesday, 1/25 10:00 a.m. – 6:00 p.m.
Closed *
Thursday, 1/26 10:00 a.m. – 6:00 p.m.
Friday, 1/27 10:00 a.m. – 5:00 p.m.
Saturday, 1/28 Closed
* Wednesday had hour changes – Due to building improvement.
Monday 10:00 a.m. – 6:00 p.m.
Tuesday 10:00 a.m. – 6:00 p.m.
Wednesday 10:00 a.m. – 6:00 p.m.
Thursday 10:00 a.m. – 6:00 p.m.
Friday 10:00 a.m. – 5:00 p.m.
Thu., Feb. 2 : Opening at 2:00 PM due to staff development
Thu., Mar. 2 : Opening at 2:00 PM due to staff development
Thu., Apr. 6 : Opening at 2:00 PM due to staff development
Donate to McPherson Square Library
Story Drumming
Tue, January 31, 2023 4:00 P.M.
Story Drumming involves a read aloud of a book, a brief review of the characters or events in the book and a syllabic drumming circle (about 10 drummers at a time) that is based on the responses…
January we are reading Farewell to Manzanar : a true story of Japanese American experience during and after WWII internment. Please email Ms. Tuesday for the zoom link.…
Printmaking Valentine's Day Cards
Mon, February 13, 2023 3:00 P.M.
Pam Draper will show teens and school- age kids the process of printmaking and together they will create cards for valentine's day.
Beads and Go
Thu, February 16, 2023 4:00 P.M.
Juanita Howard from Beads and GO will visit the branch and show school- age students how to make jewelry with beads
View all McPherson Square Library events
Set in a small neighborhood park, McPherson Square serves the neighborhoods of Kensington, McPherson Square, and K & A. It is located near the Allegheny El station.
McPherson Square Branch now resides in a domed, classically designed Carnegie building centered a small neighborhood park known as McPherson Square. Over a century ago, however, the library first opened on July 5, 1898 in an old house known as the Webster Mansion. The mansion had been the home of three generations of the prominent Webster family from 1805 until 1891, when the home and grounds were sold to the City of Philadelphia for recreational purposes. The mansion was torn down in 1915 and the current library building opened on May 25, 1917.
McPherson Square Park is named for General William MacPherson, who was the original owner of Webster Manson. General McPherson— - the son of Captain John MacPherson, a famous Scottish sea captain - —joined the patriot forces in 1776. George Washington, a close friend, was often entertained in the mansion.
In the park is a statue of Charles Allen Smith, the second American killed at Vera Cruz in 1914. Smith lived at 2168 Sergeant Street, and the statue was paid for by a collection from neighbors.
Inside the library, look for sculptured reading tables with attached seating. Woodcarver Stewart Paul was commissioned to make the tables in 1972.


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CNY Exchange rate
Russian Finance Ministry May Buy RMB Under 2023 Budget Rules
Russia's Finance Minister Anton Siluanov said that the Russian Finance Ministry will not resume foreign currency purchases this year, including RMB, and will do so only if it receives additional oil and gas revenues in 2023 beyond the budgeted base.
Earlier, the finance minister did not rule out buying "friendly" foreign currencies on the market this year, he noted, referring to the purchase of RMB. In this case, Siluanov said, the excess oil and gas revenues will be calculated using the cessation of supply prices initially set in the 2022 budget, before the suspension of budget rules due to strict sanctions against Russia.
This entry was posted in News on December 23, 2022 by admin.
RMB international settlement scale increased by 15%
According to Business News International, Kommersant cited a report by the Society for Worldwide Interbank Financial Telecommunication (SWIFT) as saying RMB international settlement rose 15.6 percent, compared with a 19.86 per cent increase in October.
International settlements in other currencies grew by 3.9 percent in the latest month, the report said.
RMB maintained the fifth most active currency for international payments, accounting for 2.37%. In November 2022, the RMB ranked sixth in terms of international payments outside the euro area, accounting for 1.63%.
Earlier on December 1, 2022, the Bank of Russia announced that the share of RMB trading volume in total foreign exchange transactions on Russian exchanges rose from 3% in March to 33% in November.
RMB internationalization indicators are generally positive
International Business News – The People's Bank of China recently released the "RMB Internationalization Report 2022", which shows that the indicators of RMB internationalization are generally positive, with RMB's payment currency function steadily improving, its investment and financing currency function further deepening, its reserve currency function rising and its denomination currency function gradually strengthening. The report also shows that the opening of China's financial market continues to advance and RMB assets remain highly attractive to global investors.
Third-party data also prove that RMB internationalization is steadily moving forward. According to the Society for Worldwide Interbank Financial Telecommunication (SWIFT), the RMB's share of international payments will increase to 2.7% by December 2021, surpassing the Japanese yen to become the world's fourth payment currency. And data released by the International Monetary Fund (IMF) on the currency composition of official foreign exchange reserves shows that the yuan's share of global foreign exchange reserves reached 2.88% in the first quarter of 2022, ranking fifth among major reserve currencies.
Normally, the U.S. dollar is the main payment currency in international trade. However, the U.S. sanctions against other countries at every turn have made many countries wary, including India and Russia.
For example, Indian companies are using more Asian currencies to pay for their coal imports from Russia, bypassing the U.S. dollar and reducing the risk associated with violating Western sanctions against Russia, according to Reuters. In July, India's coal imports from Russia rose sharply, with 31 percent of the non-dollar payments made in yuan and less than a quarter in euros, a trade source said.
Since the outbreak of the Russia-Ukraine conflict, Russia has also been consciously "de-dollarizing" and looking for alternative currencies due to U.S. sanctions. Russia's Kommersant website reported on Sept. 23 that August statistics released by SWIFT showed that Russia ranked third in the world in terms of offshore payments in yuan, ahead of Hong Kong, China and the United Kingdom.
According to the report, the yuan is the preferred alternative currency to the dollar and euro for Russian banks in the process of "de-foreignization" of the industry. Russian Deputy Finance Minister Alexei Moiseyev said this preference is due to strong demand for the Chinese currency and a stable exchange rate. Director of the First Asian Department of the Russian Foreign Ministry Georgiy Zinoviev said that the share of Russian-Chinese local currency settlements is growing and the demand and volume of transactions in the yuan on the exchange is also increasing.
At the same time, the RMB is being used as a reserve currency by an increasing number of countries. With geopolitical conflicts threatening to erode the dollar's dominance, central banks are beginning to seek to diversify their foreign exchange reserves with the yuan.
A July report on the Financial Times website noted that concerns about high inflation in the U.S. and the Federal Reserve's efforts to combat it have also put the dollar under short-term pressure. The survey showed that reserve managers are looking for other alternative assets, such as securities, green lending and inflation-protected bonds, out of concern about holding dollar-denominated assets. Nearly half of the respondents said their portfolios are more diversified than last year.
While the dollar remains the world's number one reserve currency, its lead has declined in recent years. Global central banks have reduced the dollar's share of their foreign exchange reserves over the past 20 years, with a quarter of that reduction going to the yuan, according to IMF research released earlier this year.
Experts attribute the share growth to the rise of the Chinese economy and the internationalization of the yuan, the Russia Today TV website reports. They say the yuan's share growth will also accelerate this year against the backdrop of mutual sanctions between Russia and the West and global financial chaos.
A new study shows that China's dominance in global trade is increasing the yuan's share of global central banks' foreign exchange reserves, as also reported on Bloomberg News' website in July. If China's trade and yuan settlements continue to increase, the yuan's share of reserves will grow, the study's authors argue.
Experts say that as China's economic power grows and the yuan's influence increases with each passing day, the increase in the yuan's share and size is an irreversible trend.
This entry was posted in News on October 2, 2022 by admin.
RMB becomes the 4th payment currency in the world
International Business News – According to the "RMB Internationalization Report 2022" released by the People's Bank of China, the RMB's international payment share improved to 2.7% in December 2021, overtaking the Japanese yen to become the world's fourth payment currency, and further increased to 3.2% in January 2022, a record high.
Since 2021, RMB cross-border receipts and payments have continued to grow from a high base in the previous year. 2021, the total amount of RMB cross-border receipts and payments by banks on behalf of customers was RMB 36.6 trillion, up 29.0% year-on-year and a record high. RMB cross-border payments and receipts were generally balanced, with a cumulative net inflow of RMB 404.47 billion for the year. According to the Society for Worldwide Interbank Financial Telecommunication (SWIFT), the RMB's share of international payments increased to 2.7% in December 2021, overtaking the Japanese yen to become the world's fourth payment currency, and further increased to 3.2% in January 2022, a record high. Currency Composition of Official Foreign Exchange Reserves (COFER) data released by the International Monetary Fund (IMF) show that the RMB's share of global foreign exchange reserves reached 2.88% in the first quarter of 2022, up 1.8 percentage points from 2016 when the RMB first joined the Special Drawing Rights (SDR) currency basket, ranking fifth among major reserve currencies.In May 2022, the International Monetary Fund (IMF) raised the RMB's weighting in the Special Drawing Rights (SDR) from 10.92% to 12.28%, reflecting recognition of the increased degree of free access to the RMB.
The volume of cross-border RMB settlement related to the real economy maintained rapid growth, with areas such as bulk commodities and cross-border e-commerce becoming new growth points, and cross-border two-way investment activities continued to be active. The RMB exchange rate generally showed a two-way fluctuation trend, and the endogenous demand of market players to use RMB to hedge exchange rate risks gradually grew. The basic system of RMB cross-border investment and financing, transaction settlement, etc. continues to be improved, and the ability to serve the real economy continues to be enhanced.
The opening up of China's financial market continues to advance, RMB assets remain highly attractive to global investors, and there is an overall net inflow of RMB cross-border receipts and payments under securities investment. By the end of 2021, the total amount of domestic RMB stocks, bonds, loans and deposits held by foreign entities was RMB 10.83 trillion, up 20.5% year-on-year. The offshore RMB market gradually picked up and transactions became more active. By the end of 2021, RMB deposits in major offshore markets were close to RMB 1.50 trillion.
RMB depreciates against USD
International Business News – After two years, the RMB exchange rate is back below 6.90 yuan.
On the morning of August 29, the RMB's mid-price against the USD was at 6.8698, down 212 basis points from the previous trading day. The onshore and offshore RMB/USD exchange rates both fell below the 6.90 mark, making people wonder if it will break 7 if it continues.
Why did the dollar strengthen? Julius Investment Advisory senior investment advisor Xie Logistics said in an interview with the International Business Times reporter, first, the dollar is strong relative to the euro and the yen strong, the Bank of Japan continued quantitative easing led to the yen depreciation trend is obvious, the Russia-Ukraine conflict, the eurozone capital outflow, the United States plays the role of a safe haven for funds. The second is the interest rate hike factor. The Fed's tightening monetary policy has made the US dollar appear more scarce in the global market, prompting the dollar to strengthen.
Hongze Capital founding partner and chief strategist Xu Yaxin told the International Business Times that, on the one hand, the impact of the Russian-Ukrainian geopolitical crisis in the first half of the year, high energy prices, which in turn pushed inflation higher, with the Federal Reserve as the main central banks have opened the interest rate hike cycle. Successive interest rate hikes to market expectations of the future economy into recession is expected to heat up, the dollar as a safe-haven assets continue to increase in attractiveness. On the other hand, the Fed and other central banks to widen the interest rate differential, many Fed officials frequently released hawkish remarks, while non-US currencies euro, pound and yen continued to weaken, disguised to enhance the dollar upward momentum.
"The recent hawkish remarks from the Fed's Powell, stressing that it will continue to tighten monetary policy to reach the goal of inflation control, gave great support to the short-term strength of the dollar." Chen Yucheng, a senior investment advisor at Jufeng Investment Consulting, told International Business Daily that the RMB exchange rate, as a relative price, depends on the strength of demand for the RMB versus foreign currencies. The strong dollar natural RMB will be relatively weak.
For the recent fall in the RMB exchange rate factors, Xie logistics analysis, said, one is the further relaxation of domestic monetary policy, the recent MLF and LPR interest rate cut, the exchange rate of short-term disturbance; two is the pace of the Federal Reserve interest rate hikes did not slow down, the euro continued to weaken; three is the repeated epidemic, Sichuan power restrictions and other factors make the capital for the domestic economic recovery process concerns.
"If the inversion of the interest rate gap between China and the United States continues to widen, the exchange rate has a certain possibility of breaking 7." Xie Logistics said, but the RMB's supporting factors continue to be stable, and there is no basis for long-term depreciation.
Chen Yucheng also believes that from the current account, China's exports remain resilient. In the long run, the support for the yuan comes from domestic economic repair, so there will be no unilateral depreciation, and breaking 7 is a small probability event.
"From the overall trend of the yuan this year, it is just weak relative to the dollar." Xu Yaxin gave a set of data, the yen, the euro and the British pound so far in the year, relative to the dollar depreciation of 20.65%, 12.82% and 13.82% respectively, while the yuan against the dollar only depreciated 8.87% in the year. "So, it is not critical for the RMB to break 7 against the dollar, and the RMB remains relatively strong relative to the performance of many other countries' exchange rates. The domestic adoption of an accommodative monetary policy will certainly bring depreciation pressure on the short-term exchange rate, but stabilizing economic fundamentals is more conducive to the confidence of funds in the medium and long term, and there is no need to worry too much about the short-term depreciation of the RMB against the dollar."
RMB exchange rate "broken 7"
On September 16, the 10-year Sino-US spread was inverted to 74 basis points, and the depreciation pressure on the RMB exchange rate was self-evident, with the RMB once surging to 7.0254 against the U.S. The "breaking of 7" of the RMB against the U.S. dollar immediately drew the attention of the whole market. So far this year (as of September 16, the same below), the RMB has depreciated by 9.88% against the USD, but compared to other currencies, the performance of the RMB has been relatively solid.
On August 26, 2022, at the central bankers' meeting in Jackson Hole, Fed Chairman Powell's hawkish statement implied that the Fed would continue its aggressive rate hike and tapering policy. Since then, the yield on the 10-year U.S. Treasury note has moved higher again, climbing to 3.44% by September 16. Wall Street predicts that the U.S. 10-year Treasury yield will rise to 3.75 percent by the end of the year and will peak at 4.0 percent in 2023. So far this year, the dollar index has risen 14.65%.
Both the euro and the yen have fallen to 20-year lows against the dollar. As of Sept. 16, the dollar had depreciated 38.4 percent against the yen from the end of 2020 all the way through the year. The euro, which has been falling against the dollar since June 2021, depreciated by a total of 22% by Sept. 16. The British pound has also been on the decline since June 2021, depreciating by 24.3% against the dollar by September 16. This is still the currency trend of major economies, and some developing countries have seen even more outrageous currency depreciation.
In terms of horizontal comparison with other currencies over the same period, the RMB real effective exchange rate index has only declined slightly by 2.8% this year, the reason behind this is that the RMB has appreciated significantly against other mainstream currencies, with the RMB appreciating 3.1% against the Euro, 6.2% against the British Pound and 12.6% against the Japanese Yen since the beginning of the year. From the perspective of a basket of exchange rates, the overall CFETS RMB exchange rate index is still appreciating from the beginning of the year, reflecting that the RMB exchange rate index is not weak so far this year. This indicates that the weakening of the RMB is only relative to the USD.
The logic behind the "broken 7" exchange rate
The analysis of the bilateral exchange rate, in the long run, depends mainly on the difference in labor productivity between the two countries, that is, in the framework of the "Balassa-Samuelson effect". However, in the short to medium term, the main factors determining the bilateral exchange rate are the difference in economic growth between the two countries, the inflation differential and the interest rate differential between the two countries, as well as the sentiment of international investors derived from these three factors.
Since 2022, the RMB has depreciated against the USD, mainly due to the rapidly widening long-term interest rate differential between the US and China and the pessimistic investor sentiment caused by expectations of economic growth.
Since 2020, the U.S. economy has grown strongly, with the U.S. manufacturing PMI consistently above the RongKu line and a more stable level of non-manufacturing PMI. The preliminary U.S. University of Michigan Consumer Confidence Index for August was 55.1, up 7 percent from the previous year. On the capacity side, capacity indicators, such as industrial, manufacturing, and consumer goods output, have been picking up since the second quarter of 2020 and have surpassed their pre-epidemic levels since the second quarter of 2022.
In addition, the U.S. job market remains strong, with 315,000 new nonfarm payrolls in August, higher than the expected value of 300,000, and an unemployment rate of 3.7%, the highest since February this year; the labor force participation rate of 62.4%, the highest since the epidemic. The unemployment rate has been declining since April 2020 at 14.7% and will largely return to its pre-epidemic low by the second quarter of 2022, demonstrating strong employment resilience.
The Russian-Ukrainian conflict has brought about rising international energy prices and sudden inflationary pressure in the U.S. The U.S. CPI reached 8.5% year-on-year in July. Against this backdrop, the Federal Reserve has chosen to tighten its monetary policy, from the initial reduction in the size of quantitative easing to the subsequent successive rate hikes, and the rate hikes are large and expected to accelerate tapering in the future.
After the market expects the Fed to keep tightening monetary policy, the U.S. 10-year Treasury yield has climbed significantly, from the beginning of the year all the way up to 3.44% now. Investors now expect the Fed to raise interest rates by 75 basis points next and expect the yield on the 10-year U.S. Treasury to rise to 4 percent next year.
In China, economic growth slowed significantly in the second quarter, with GDP growth of just 0.4% year-on-year, as many parts of the country were hit by the epidemic. Concerns in the foreign exchange market about the future of the Chinese economy followed.
In order to achieve stable growth, the central bank adopted a moderately accommodative monetary policy. The central bank cut the medium-term lending facility (MLF) and open market reverse repo (OMO) rates by 10 basis points each on Aug. 15, exceeding market expectations. It then guided the loan market offer rate (LPR) down in line with the trend, including a 5 basis point cut for the 1-year period and a 15 basis point cut for the 5-year period and above, increasing support for medium- and long-term loans such as real estate mortgages.
The reverse operation of the central bank and the Fed caused the long-term interest rate differential between the two countries to widen rapidly. By Sept. 16, the U.S. 10-year Treasury yield was 74 basis points higher than the Chinese 10-year Treasury yield. The inverted and widening spread between the U.S. and China could trigger some cross-border capital flows from China to the U.S., which could depress the yuan against the dollar.
Since July and August, the epidemic has eased. On September 16, the National Bureau of Statistics announced the economic data for August. On the whole, the economy has gradually recovered, infrastructure has remained relatively resilient, manufacturing investment is still strong, the year-on-year growth rate of total retail sales of social consumer goods has rebounded to 5.4%, and the national urban unemployment rate has been surveyed. Further downside to 5.3%.
However, economic concerns remain. Exports fell sharply in August, real estate was weak, and various real estate data still failed to stabilize and rebound, and were still in the process of bottoming out. The unemployment rate for youth aged 16 to 24 in August was 18.7%, indicating that youth employment pressure is still relatively high. In addition, both corporate deposits and household deposits showed super-seasonal growth in August, reflecting the weak willingness of enterprises and households to spend.
Under such a situation, the central bank will pay more attention to the domestic economic trend than the exchange rate. After all, the important factor that determines the future exchange rate trend is the strong growth of the future economy, so the central bank still chooses a moderately loose monetary policy. The six state-owned banks of China Construction Communications and Postal Savings Bank, as well as China Merchants Bank, announced in unison that they would cut interest rates on personal deposits. This reverse operation will further widen the 10-year interest rate gap between China and the United States in the short term, increasing the short-term depreciation pressure of the RMB.
The impact of a weaker renminbi
For example, airlines, real estate, etc., will worsen their balance sheets. But for the export processing industry, it will obviously increase their international competitiveness and will improve their business conditions. in August, China's exports grew by 7.1% year-on-year in dollar terms, a sharp drop from the growth rate in June (17.9%) and July (18%), and a moderate devaluation is good for stabilizing exports.
In the financial markets, the outflow of funds will increase the volatility of the market.
As far as the stock market is concerned, overseas funds can influence the Chinese stock market through the Shanghai-Hong Kong Stock Exchange, Shenzhen-Hong Kong Stock Exchange and QFII, but the current openness of the Chinese stock market is not too high, and the change of these funds will only have a limited impact on the market in the short term, and the main factor affecting the stock market in the medium and long term is the trend of the Chinese economy. If the Chinese economy can return to a higher growth rate in the future, or form a new economic growth cycle, then the Chinese stock market will naturally come out of the good market, and of course the RMB exchange rate will be strong.
However, we cannot ignore that the market sentiment brought by the strong dollar will increase the volatility of the financial markets, and if we do not grasp the rhythm, it may trigger panic among investors, which needs to be wary.
Of course, at present, the central bank has many tools to prevent sharp fluctuations in the local currency exchange rate, such as counter-cyclical factors, foreign exchange deposit reserves, forward foreign exchange sales reserves, capital flow management, and macro-prudential management at the foreign exchange level. And judging from the trend of the renminbi this year, the central bank has also used these tools. For example, after the Federal Reserve announced interest rate hikes this year, the central parity rate of the renminbi against the US dollar exceeded market expectations. In contrast, the exchange rate of the RMB against the US dollar has remained relatively stable, which shows that the central bank is already using these tools to adjust.
Even in the worst case scenario and investor panic, as China has not fully opened its capital account, the central bank can limit short-term capital outflows in the event of sustained large-scale capital outflows, such as limiting the number of foreign exchange exchanges, or levying trusteeships. Bin tax and other methods to stabilize the market.
Therefore, given the moderate depreciation of the RMB against the U.S. dollar and the relative flexibility of the RMB exchange rate formation mechanism, there is no need to worry about the sharp depreciation of the RMB, much less the financial market turmoil that some investors worry about.
Prediction of the future trend of RMB
The trend of a country's exchange rate is ultimately determined by the country's economic development capability, that is, how the RMB exchange rate will trend in the future depends on the fundamentals of China's economy in the future.
Therefore, China's monetary policy is still based on the fundamentals of its own economic development, and the exchange rate market is only one factor that needs attention in the short term. At present, China's economy is still lacking in aggregate demand, so monetary policy will remain moderately loose to achieve stable growth, and interest rate cuts will remain policy options in the future. Moreover, in fact, under the premise that the world's major currencies are depreciating sharply against the US dollar, the moderate depreciation of the RMB against the US dollar will help maintain the stability of the effective exchange rate of the RMB, and there is no need to hold it dead.
To assess the future direction of the US dollar index, it is also necessary to look at the relative position of the euro area and Japan. Since 2021, the manufacturing and service PMIs in the euro area have also been on a downward trend. In August, the manufacturing PMI recorded 49.6, falling below the line of prosperity and decline and hitting a new low in 18 months. Inflation in the euro zone hit 8.9% year-on-year in July, driven by the energy crisis.
In Japan, the macroeconomic situation is still hardly optimistic. 2022 years, the impact of the Russia-Ukraine conflict and rising energy prices, Japanese machinery orders fell and the CPI index rose sharply. Japan is highly dependent on energy imports, and imported inflation poses a big challenge to the Japanese economy. The BOJ's assessment of the downside risks to the economy remains higher than the upside risks to inflation and continues to maintain an accommodative policy orientation.
In the short term, inflation in the U.S. will remain high and the economy is still operating in an expansionary region, and the Fed is expected to continue to implement interest rate hikes and tapering and adopt a tight monetary policy.
Taken together, the dollar index is expected to rise further in the coming period.
Since China implements a monetary policy based on China, even if the exchange rate of RMB against the US dollar "breaks 7" in the short term, there is no need to make a fuss. With the evolution of the Fed raising interest rates and shrinking the balance sheet, the US economy may enter a recession in the future. In the future, China will focus more on economic growth. If the economic growth rate picks up significantly, the exchange rate of RMB against the US dollar will return to the appreciation channel.
This entry was posted in News on September 23, 2022 by admin.
Copyright © 2023 CNY


text:
Avocados From Mexico Is Turning Guacamole Addiction Into Consumer Data
Mobile Beacons and an Under Armour Partnership
By Kate Kaye. Published on November 06, 2015.
Harvested avocados sit at the Frutas Finas de Tancitaro plant in Tancitaro, Mexico, in July.
Credit: Brett Gundlock/Bloomberg
Call it the Internet of Green Things. Avocados From Mexico, an organization that manages marketing of Mexican avocados in the U.S., operates around 250 web-connected displays in grocery stores and is turning its AvoLifestyle initiative into digital data through a partnership with Under Armour's MyFitnessPal, a weight loss and fitness tracking app. Perhaps better-known for its first Super Bowl commercial earlier this year, the group also began a mobile ad campaign last week targeting previous avocado buyers when they're in a supermarket parking lot or in the store itself.
Food brands often have relatively limited insights into their consumers, with grocery retailers holding detailed transactional data close to the vest. For produce marketers, the view can be even more obstructed. Price look-up codes for avocados, for example, don't distinguish between avocados from Mexico or California.
But a growing portion of Avocados From Mexico's funds, now 30% of its media buy, goes towards digital efforts intended partly to soak up data and insights on consumers who buy or might be convinced to buy the buttery-rich fruit most associate with guacamole.
"The last three years it's been the category of our budget that has gown the most," said Alvaro Luque, president of the group.
The association is working with NectarOM, an omni-channel marketing platform, to manage a database intercepting information from that array of digital programs.
Avocados From Mexico is connecting to fitness-minded people through a relationship with the MyFitnessPal app. Users can register for the AvoLifestyle Challenge, a contest encouraging participants to log 15 meals that include a serving of avocado this December. Winners get a customized meal plan from a nutritionist and will be entered to win a $500 Under Armour gift card.
Data flowing from the group's email marketing and digital advertising, its in-store beacons, social media interactions, mobile location data from its ad partner Verve Mobile, and consumer interactions with its AvoLifestyle program through MyFitnessPal all filters into the system managed by NectarOM.
"Every time that we invest in something … we're capturing that information to create a database that at the end we can personalize, we can segment, we can target and remarket," said Mr. Luque. Avocados From Mexico is gradually converting its 1,000 branded grocery displays to feature mobile beacons that promote its iAvocado app and recognize devices that have downloaded it. Combined with mobile ads touting the app, the effort has yielded 20,000 downloads so far, according to the group.
"We're just starting with it but now we have a cool base of customers," Mr. Luque said.
"It's how we're mixing technology with point of sales," he added.
The trade group announced recently that it has re-upped to run another Super Bowl spot in February, part of its ongoing goal to establish its name as a healthy brand.
And, most recently, the in-app mobile campaign begun last week is targeting sports fans, football tailgaters, Hispanic moms and other segments such as those who might have been spotted via mobile location trackers inside a grocery store. Avocados From Mexico is using Verve Mobile to aim ads at people who have bought avocados in the last six months, based on Nielsen Catalina's household-level purchase data tied to mobile devices.
"It's an actual data match," said Julie Bernard, CMO, Verve Mobile.
In some cases, a consumer might be served an expandable ad while outside a supermarket reminding her to buy avocados. Inside the store, Verve can target a different ad message with tips on how to choose an avocado. Later, consumers might see ads describing how best to ripen the fruit.
Kate Kaye
Kate Kaye covers the data industry for Advertising Age and is the main contributor to the Ad Age DataWorks section. Before joining Ad Age in November 2012, Kate worked as a writer and reporter covering the digital marketing industry since 2000, focusing on beats including data-driven targeting, privacy, and government regulation. Kate helped cultivate the online political campaign beat, and in 2009 wrote "Campaign '08 A Turning Point for Digital Media," a book about the digital media efforts of the 2008 presidential campaigns. Before joining Ad Age, Kate was managing editor of ClickZ News, where she worked for nearly 7 years.
Sam Elliott's spoken-word 'Old Town Road' is the Doritos teaser you didn't know you needed


Today on the Suss-X Files…Meghan Markle and Prince Harry's new home, Frogmore Cottage at Windsor, reportedly has a very spooky history.
Ghosts, mausoleums, graveyards…It's not a first homeowner's dream, to be sure. According to Hello!, Megs and Henry may need to call in a medium, because the next-door-neighbor castle (casual) could be haunted.
Before you grab the Ouija board, though, these ghost stories need to be taken with a grain of salt. Media coverage of the so-called spooky past is all centered around the fact that nearby Windsor Castle (where the Sussexes got married) has had ghost sightings before.
Frogmore Cottage, which is currently undergoing renovations to make it livable for Harry and Megs plus baby, is located about a mile and a half from the castle, on the Windsor estate.
Also located on the estate: a private cemetery, where Queen Elizabeth's Uncle Edward and his wife, Wallis Simpson, are buried and two royal mausoleums, which contain the tombs of Queen Victoria and Prince Albert, as well as Queen Victoria's mother, the Duchess of Kent.
Windsor ghost sightings of King Henry VIII pacing the halls of the castle, as well as his beheaded wife, Anne Boleyn, have been reported in the past. The king is buried at St. George's Chapel in Windsor Castle.
Prince Harry and Markle may or may not believe in ghosts, but we know we'd keep our guard up for the first few weeks in the new home if we were them.
And Anne Boleyn is getting a new yoga studio, so she can chill, OK?


text:
Tim-4 (human):Fc (human) (rec.)
CHI-HF-210T4-C100100 µgCHF 510.00
TIM4; TIMD4; T Cell Immunoglobulin and Mucin Domain-containing Protein 4; T Cell Membrane Protein 4
Source/Host
The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of human IgG1.
Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
≥98% (SDS-PAGE)
Endotoxin Content
<0.06EU/μg protein (LAL test; Lonza).
Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.
Lyophilized from 0.2μm-filtered solution in PBS.
Protein Negative Control
Fc (human) IgG1 Control (rec.)
NCBI reference NP_612388.2: Tim-4 (human)
Manufactured by Chimerigen.
Handling Advice
Avoid freeze/thaw cycles.
Working aliquots are stable for up to 3 months when stored at -20°C.
The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell; immunoglobulin; Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.
TIM-4 is the ligand for TIM-1, and the TIM-1–TIM-4 interaction regulates T cell proliferation: J. Hartt Meyers, et al.; J. Immunol. 6, 455 (2005)
Tim-4 expressed on antigen-presenting cells induces T cell expansion and survival: R. Rodriguez-Manzanet, et al.; J. Immunol. 180, 4706 (2008)
Tim-4 (mouse):Fc (human) (rec.) CHI-MF-111T4
Tim-4 (mouse):Fc (mouse) (rec.) CHI-MF-110T4
Tim-4 (human):Fc (mouse) (rec.) CHI-HF-211T4


text:
package com.ait.lienzo.charts.shared.core.types;

import java.util.List;

import com.ait.lienzo.client.core.types.NFastStringMap;
import com.ait.lienzo.shared.core.types.EnumWithValue;

public enum ChartDirection implements EnumWithValue
{
    POSITIVE("positive"), NEGATIVE("negative");

    private final String                                m_value;

    private static final NFastStringMap<ChartDirection> LOOKUP_MAP = Statics.build(ChartDirection.values());

    private ChartDirection(String value)
    {
        m_value = value;
    }

    @Override
    public final String getValue()
    {
        return m_value;
    }

    @Override
    public final String toString()
    {
        return m_value;
    }

    public static final ChartDirection lookup(String key)
    {
        return Statics.lookup(key, LOOKUP_MAP, POSITIVE);
    }

    public static final List<String> getKeys()
    {
        return Statics.getKeys(ChartDirection.values());
    }

    public static final List<ChartDirection> getValues()
    {
        return Statics.getValues(ChartDirection.values());
    }
}


text:
package org.owasp.dependencycheck.dependency;

import static org.junit.Assert.assertTrue;
import static org.junit.Assert.assertFalse;

import org.junit.Test;
import org.owasp.dependencycheck.BaseTest;
import us.springett.parsers.cpe.exceptions.CpeValidationException;
import us.springett.parsers.cpe.values.LogicalValue;
import us.springett.parsers.cpe.values.Part;

/**
 *
 * @author Jeremy Long
 */
public class VulnerableSoftwareTest extends BaseTest {

    /**
     * Test of equals method, of class VulnerableSoftware.
     *
     * @throws CpeValidationException
     */
    @Test
    public void testEquals() throws CpeValidationException {
        VulnerableSoftwareBuilder builder = new VulnerableSoftwareBuilder();
        VulnerableSoftware obj = null;
        VulnerableSoftware instance = builder.part(Part.APPLICATION).vendor("mortbay").product("jetty").version("6.1").build();
        assertFalse(instance.equals(obj));

        obj = builder.part(Part.APPLICATION).vendor("mortbay").product("jetty").version("6.1.0").build();
        instance = builder.part(Part.APPLICATION).vendor("mortbay").product("jetty").version("6.1").build();
        assertFalse(instance.equals(obj));

        obj = builder.part(Part.APPLICATION).vendor("mortbay").product("jetty").version("6.1.0").build();
        instance = builder.part(Part.APPLICATION).vendor("mortbay").product("jetty").version("6.1.0").build();
        assertTrue(instance.equals(obj));
    }

    /**
     * Test of compareTo method, of class VulnerableSoftware.
     *
     * @throws CpeValidationException
     */
    @Test
    public void testCompareTo() throws CpeValidationException {
        VulnerableSoftwareBuilder builder = new VulnerableSoftwareBuilder();
        VulnerableSoftware obj = builder.part(Part.APPLICATION).vendor("mortbay").product("jetty").version("6.1.0").build();
        VulnerableSoftware instance = builder.part(Part.APPLICATION).vendor("mortbay").product("jetty").version("6.1").build();
        int result = instance.compareTo(obj);
        assertTrue(result < 0);

        obj = builder.part(Part.APPLICATION).vendor("yahoo").product("toolbar").version("3.1.0.20130813024103").build();
        instance = builder.part(Part.APPLICATION).vendor("yahoo").product("toolbar").version("3.1.0.20130813024104").build();
        result = instance.compareTo(obj);
        assertTrue(result > 0);
    }

    @Test
    public void testCompareVersionRange() throws CpeValidationException {
        VulnerableSoftwareBuilder builder = new VulnerableSoftwareBuilder();
        VulnerableSoftware instance = builder.version("2.0.0").build();
        assertTrue(instance.compareVersionRange("2.0.0"));
        assertFalse(instance.compareVersionRange("2.0.1"));

        instance = builder.version(LogicalValue.ANY).build();
        assertTrue(instance.compareVersionRange("2.0.1"));

        instance = builder.version(LogicalValue.NA).build();
        assertFalse(instance.compareVersionRange("2.0.1"));

        instance = builder.version(LogicalValue.ANY).versionEndIncluding("2.0.1").build();
        assertTrue(instance.compareVersionRange("2.0.1"));
        assertFalse(instance.compareVersionRange("2.0.2"));

        instance = builder.version(LogicalValue.ANY).versionEndExcluding("2.0.2").build();
        assertTrue(instance.compareVersionRange("2.0.1"));
        assertFalse(instance.compareVersionRange("2.0.2"));

        instance = builder.version(LogicalValue.ANY).versionStartIncluding("1.0.1").build();
        assertTrue(instance.compareVersionRange("1.0.1"));
        assertFalse(instance.compareVersionRange("1.0.0"));

        instance = builder.version(LogicalValue.ANY).versionStartExcluding("1.0.0").build();
        assertTrue(instance.compareVersionRange("1.0.1"));
        assertFalse(instance.compareVersionRange("1.0.0"));
    }

    @Test
    public void testcompareUpdateAttributes() throws CpeValidationException {

        assertTrue(VulnerableSoftware.compareUpdateAttributes("update1", "u1"));
        assertTrue(VulnerableSoftware.compareUpdateAttributes("u1", "update1"));
        assertTrue(VulnerableSoftware.compareUpdateAttributes("u1", "update-1"));
        assertTrue(VulnerableSoftware.compareUpdateAttributes("a1", "alpha1"));
        assertTrue(VulnerableSoftware.compareUpdateAttributes("alpha-1", "alpha1"));
        assertTrue(VulnerableSoftware.compareUpdateAttributes("b-1", "beta1"));
        assertFalse(VulnerableSoftware.compareUpdateAttributes("a1", "beta1"));

    }

}


Vienna, May 12: UN Secretary General Kofi Annan urged the United States again today to enter direct talks with Iran to ease a crisis over Iranian nuclear work after Washington vowed not to be drawn into ''endless'' dialogue.
A senior US official yesterday ruled out US-Iranian contact to help solve an international standoff over Tehran's nuclear work and said sanctions must be part of a new carrots and sticks offer to try to curb Iranian atomic activity.
''I have ... stated very clearly both in private contacts with the American administration and publicly that I think it is important that the United States come to the table and join the European countries and Iran to find a solution,'' Annan said at a Vienna summit of European Union and Latin American countries.
''(This is) because I really believe that as long as the Iranians have the sense they are negotiating with the Europeans ... and what they discuss with them will have to be discussed with the Americans and then (brought) back again to them..., they will not put everything on the table,'' Annan said.
Annan made a similar suggestion on US public television last week. He has long been pushing for a diplomatic solution to avoid a resort to UN sanctions or even military action, a last-resort option mooted by the United States and Israel.
''I've asked all sides to lower their rhetoric and intensify diplomatic efforts to find a solution,'' Annan told reporters.
''I'm happy that the (Security Council) discussions seem to have led to a situation where everyone agrees that not only should one come back to the table and negotiate but there should be a comprehensive package proposed for discussions by all.'' In the latest effort to resolve the crisis, Britain, France and Germany, with backing from the United States, Russia and China, are to unveil in the next 10 days a package of inducements and penalties for Iran.
While Iran insists it wants only to enrich uranium as nuclear energy for its economy, the West suspects that programme could be a front for an atomic bomb project.