text:
Can Web3 be hacked? Is the decentralized internet safer?
Coin Telegrapgh , Guides
Web3 came into existence posed as a blockchain-powered disruption to the current state of the internet. Yet, as a nascent technology, a fog of assumptions plagues discussions about the real capabilities of Web3 and its role in our day-to-day lives.
Considering the promise of a decentralized internet using public blockchains, a complete transition to Web3 would require scrutiny across several factors. Out of the lot, security stands as one of the most crucial features as, in a Web3-powered world, tools and applications hosted over the blockchains go mainstream.
Smart contract vulnerabilities
While the blockchains that host Web3 applications remain impenetrable from being hostage to attackers, hackers target the vulnerabilities within the project's smart contracts. Smart contract attacks on decentralized finance (DeFi) platforms have surged, with a recent study revealing that approximately $1.6 billion in cryptocurrencies was stolen in the first quarter of 2022 alone.
Although DeFi is a subset of the Web3 spectrum, it reflects the biggest vulnerability within the ecosystem. As a result, Web3 entrepreneurs need to redirect their marketing budget to the development of the core system.
As seen throughout the year, vulnerabilities that allow hackers to drain vast amounts of assets result in impermanent losses for the investors and may cause an indirect collapse of related ecosystems.
In addition to external hacks, bad actors within the system may dupe the project and its investors. Fail-safe mechanisms with watered-down access to employees are required to avoid internal attacks.
On Aug. 14, trading and liquidity automated market maker (AMM) Velodrome Finance recovered $350,000 from one of its team members, Gabagool. One of Velodrome's high-worth wallets was drained off $350,000. A following internal investigation revealed the attacker's identification, allowing the company to recover the entire loot.
Fortifying Web3
Over six months of the bear market coupled with countless hacks have forced crypto investors to realign their investments with ecosystems that reflect safety. As a result, Web3 entrepreneurs are expected to take measures that ensure the long-term success of their offerings.
One way to minimize the risks of an attack is to conduct bug bounty initiatives. Bug bounties attract whitehat hackers, who try to identify vulnerabilities from a hacker's perspective. Developers are rewarded financially for finding and fixing valid bugs in the system.
In addition, entrepreneurs must set up multisig wallets for storing funds and avoid centralized control over the wallets. Such measures, when implemented across the system, reflect a greater decentralization and insulation from orchestrated attacks.


Moonscrye and I were discussing my plans for the upcoming battle, when we witnessed Thomas toss Alban around like a rag doll, using telekinesis. It was a bit disturbing. I don't know what got into him. He left Alban on the ground, turned, and headed for the woods.
Moonscrye and I followed Thomas into the woods. He sees us, then stops to turn facing us.
"Thomas, what was the meaning of that?" I call out.
"They are accurate visions?" He looks pale.
Thomas' face changed expressions from relief to anger. "I know what that means and I can't let it happen here!" He turns and runs into the woods.
I call out, "Thomas!" No good, he is gone.
"Thanks. Take this, you should be able to reach him with it." It is the communications pen. I explain how to use it. Moonscrye heads back to her wagon and I call out one more time to Thomas.
"Thomas," I hear him shout again.
After walking a bit, Wylde got a bit curious.
After a few more minutes, we reach a small cave. I walked in first and lit the torch I had prepared. "Come on in," I said.
"What is this place?" asked Wylde.
"You may go now, Wylde," Cassandra said, entering the cave.
"Service!" I said with approval.
With that, he exited the cave and headed back towards the town.
"Will you be revealing your true nature," I asked the woman.
"If it comes to that, yes," she answered.
Without saying anything further, she left. I went ahead and got the gear ready for transportation. I then went back into town to pick up my packages that I had purchased earlier. I got some strange looks too. I guess it's not often that people are thrown into wagons by the gesture of hands. Oh well, they'll get over it, or not. I began to head back to the forest, but then decided I'd tell Wylde about my little color-change plan. That way, he could inform whoever was in charge of spreading the word. He understood what I was planning and thought it to be a great idea. After letting him know, I also told him that I would be near the cave until the war started and to please come get me when it was time. Now it was time for me to do some serious meditating, so I headed back to my cave to think. Maybe something would come to me.
So that was that. I went off to meditate, among other things. I also had to hurry up and finish my clothes before the war started. After all, if I was to die, I wanted to look good doing it. So after I spent two days non-stop making my new clothes, which by the way looked really cool, I went ahead and had my big meal before war. From what I heard, I now had around four days to meditate. And I was going to use every bit of that time preparing mentally. I ate my meal, donned my new clothes, and sat down in a cool dry place and began to meditate. I figured they'd wake me when it was time.
"The war is about to begin," he responded.
"My queen," he ended with a bow.
I return to the caravan and check on Alban. He is bruised, but nothing appears broken. Moonscrye took him to his wagon to check him out more thoroughly.
Thomas gave me a lot to think about, he seems to have developed quite an arsenal to deal with the vampires.
The nameless girl is waiting at my wagon, asking about Thomas. I give her a rough outline of the events and tell her that I can't stay around to fill in the blanks. When asked why, I tell her that I would explain it over lunch.
Agreeing, we dine in the Fox and Hound. She barely touches her food. I leave out my plans with my spells and Thomas' devices, but explain that I will leave with a scouting party to examine the area north of Talladale. I expect to run into scouting parties of the enemy. She was intrigued at that and asked to tag along.
Thomas intercepts us as we leave the Fox and Hound and tells me of the color-changing plan. That would explain the visions that Moonscrye saw and it makes perfect sense. The enemy may be wearing similar uniforms to ours, to confuse our army. Our military will be prepared for that eventuality. He continues on to other tasks.
The girl and I get our horses and meet with the scouts. I explain to Captain Willows, Thomas' plan. He thought it was daft, but when I explained the reason, he went pale. Understanding Thomas' plan now, he will pass the word throughout the town. They will be ready!
The scouts are brought into the office. We have a brief introduction and explanation. Then we head for the woods of Armagh Valley.
The details of our scouting excursion are extremely boring, so I will be brief.
The maps are extremely helpful and the scouts know their job very well. We locate the best place for an attack. The road is the only area where an army can pass. There are several places where an ambush can be set, where the road narrows too much for an easy retreat. I hope to get the enemy into the open area, after they leave one of the narrow passages. If I can pin them back into a narrowing, they will trample themselves in a retreat. If any leaders are in the rear, they will be the most vulnerable. I memorize the details of these places. I also locate areas I can teleport to for distance viewing of the valley.
We find several places where this style of attack could work, each of them are miles from Talladale. The farther out, the more opportunity I will have at re-doubling my attacks.
In the evening, we encounter creatures that the girl and I are able to dispatch. I notice that she takes the opportunity to dine on the soul of the creatures. With each creature she drains, she appears healthier.
I make special note to myself, about her use of the living chain she wears. I can see how she used it to attack Thomas and realize how lucky he was to survive. I will venture to avoid it myself.
The scouts, who appear afraid of very little, have a healthy respect for the girl's skill in fighting.
We are at it most of the evening. The further north we move, the more creatures we encounter. We dispatch them quickly and effectively, because we can't permit them to escape to warn the enemy. The girl is able to extract some information from some of them before dispatching them. Thus, we are able to determine where the larger body of the army is located.
We find an isolated spot off the road and camp out, taking shifts sleeping in pairs. We continued travel the following day and early into the following night.
Eventually, we progress so far north, that it is too dangerous to continue. We are running into larger parties of creatures. We ride back quickly for nearly a mile, then I gather us together in a tight formation. We slow the horses to a slow gait and I explain that it is time to take the express to Talladale. With the horses close enough to be touching, I visualize the details of Caravan Road and we teleport through, appearing near the caravan. The scouts are startled but recover quickly. They know what I was doing, because they knew I was a mage and the overall purpose for scouting the Armagh Valley.
We ride to the military headquarters and file a report of our activities, including notation on the map. Colonel Willis Wynne can look at the report and estimate when they may arrive. We stable the horses and retire for the evening. The Colonel will contact us when he feels it necessary.
I return to my wagon to get very little rest, the sun will be up soon.
I get a few hours sleep before I am summoned. An emergency meeting of the officers is beginning. When I get there, I learn that our excursion was fruitful. The timetable is moved up, the enemy will reach us in less than a week.
During my absence, Moonscrye briefed Captain Willows about the probability of vampires in the attack. The town has been active in making items that can be used against them: wooden stakes, holy water, and the devices that Thomas invented. Some protective items will be used to help, but not for the entire population.
My report confirms the worst.
The town is mobilized full time in weapon production for natural and unnatural enemies. Until further notice, everyone is to stay together in at least groups of three with an alarm bell in each building. At night, everyone is rounded up to sleep in the large warehouses, with no exceptions. The guards can be posted around a smaller area to protect more people. During the day, they can return to their normal routines - until an alarm is sounded.
Of course there are those who disregard such laws, they are often known as casualties. I disregard the laws, because no one wants to go where I go. They fear that place as much as they fear the vampires.
At the conclusion of the meeting, I contact my friends to let them know the situation. News spreads quickly and townspeople go to the warehouses to see where they will stay; they want to see if it looks safe there. There may be panic, but we have a plan to help the people. In the warehouses, the people are kept busy by making items to combat the vampires. Everyone is busy with preparations for defense and shelter. The military is being trained to use the items Thomas designed. Not much more can be done.
Later in the week, I stop at the weapon-smith and tell him that I am there to pick up Thomas' customs. He hands me two large neatly wrapped packages. I thank him and return to my wagon to collect my travel gear. I open the packages and I am surprised at what I found.
The first item is a silver fencing sword made of pure silver, coating another material the smithy mixed in to give it strength and give. The hand guard has four crosses that extend from it like a relief sculpture. The handle is coated with rubber and leather to give it comfort and to prevent slipping. The pummel of the handle has the head of a horse on it, similar to that of a chess piece. Another added feature is that handle grip is hollow with a hole above the guard. Twisting the head of the horse off to reveal the container in which I can put holy water, poison, or whatever I need to. With some work, it can also hold one of the dart pens. It also comes with a good quality leather scabbard. Near the guard are also serrations and a small blade for cutting ropes and such.
The other item is a small hand shield of silver and stronger materials. It has basic decorations on it, then a large cross, and on top of the cross is the profile of a horse's head. There are only two other features to it. The first is that I can undo the leather from the back to reveal a slide compartment which can hold something small and thin. The other is a small cap that can unscrew from the center of it and be replaced with a long silver spike. The spike can be secured to the back of the shield if desired. The shield can be attached to my belt to wear over the hip.
I am very pleased with the gifts and I keep them with me, wearing both blades and the shield.
I spend my time with Cassandra: learning and practicing spells, discussing our plans, and absorbing ley-line energies. When the time comes, I will go to the cave to find Thomas and we will begin the counter-attack.
Some evenings I spend time at the Fox and Hound Tavern, to drink and socialize with the villagers. It is a time spent to unwind from the day's events and listen to songs and tales of life in Talladale. I listen to the music and the tales, feeling as though I am a part of this place. A ballad comes to mind unbidden. I don't know how I remember this, but one of the tunes strikes a familiar chord. Michael, the chef of the tavern, calls out my name to lead the next tune or tale. I humbly acquiesce.
"I've worked on farms and from the start, the muckle horses won my heart.
With their big broad backs, they proudly stand, and uncrowned kings of all the land.
And yet for all their power and strength, they're as gentle as a summer's wind.
So steady boys, walk on, our work is nearly done.
No more we'll till or plough the fields, the horse's day is gone.
And this will be our last trip home, so steady boys walk on.
You'll hear men sing their songs of praise, of Arab stallions in a race.
Or hunters that fly with the hounds, to chase the fox and run him down.
But none of them compare I vow, to a working pair that pulls the plough.
All the years I've plied my trade, and all the fields we've ploughed and laid.
I never thought I'd see the time when a Clydesdale's work would ever end.
But progress runs its driven course, now tractors have replaced my horse.
As we head back, our friends have lined the road to see one last time.
Not one of them will want to miss, the chance to see us pass like this.
They'll say they saw in years to come, the muckle horses' last trip home.
We repeated the song. This and other tales followed. Soon, the villagers felt strengthened to maintain their way of life and were ready for the battle ahead. They would brace themselves for whatever may come.


text:
Network Board
Democratic governance in a turbulent age
Transformations to Sustainability
Dynamics of Inequality Across the Life-course: structures and processes (DIAL)
Welfare State Futures
Migration in Europe – Social, Economic, Cultural and Policy Dynamics
Re-emergence of Religion as a Social Force in Europe?
NORFACE and HERA launch a new programme – CHANSE Transformations: Social and Cultural Dynamics in the Digital Age
Transformations to Sustainability projects respond to COVID-19 crisis
High number of working papers published by DIAL research teams
This project has received funding from the European Union's Horizon 2020 research and innovation programme, the Seventh Framework Programme for research, technological development and demonstration and the Sixth Programme for research and technological development
New Opportunities for Research Funding Agency Cooperation in Europe (NORFACE) is a partnership of national research funding agencies in Europe dedicated to leading and developing opportunities for scientists in the area of social and behavioural sciences. NORFACE plays an important part in responding to the grand societal challenges by promoting research of the highest quality, sharing best practices among research funders and especially by making international collaboration between social scientists in Europe possible. From challenges brought on by migration and inequality to preparing for the impact of an aging society, researchers in the social sciences in Europe are looking at the behaviour of individuals and groups, and the dynamics of institutions and societies within Europe to understand and address these societal challenges.
Network board members
News_
NORFACE and HERA launch a new programme – CHANSE Transformations: Social and Cultural Dynamics in the Digital Age11/12/20
The NORFACE and HERA networks are pleased to announce that the CHANSE (Collaboration of Humanities and Social Sciences in Europe) consortium will soon announce a call for international research projects on 'Transformations: social and cultural dynamics in the digital age'. CHANSE will support new an
Recruiting a Scientific Programme Coordinator for research programme Democratic Governance in a Turbulent Age28/05/20
NORFACE is in search for a Scientific Programme Coordinator for its ERA-NET Cofund research programme Democratic Governance in a Turbulent Age (Governance). The Scientific Programme Coordinator will promote cohesion and cooperation in the programme by communicating the activities, outcomes and succe
Transformations to Sustainability projects respond to COVID-19 crisis12/05/20
The COVID-19 coronavirus crisis is affecting all members of the Transformations to Sustainability community and posing new questions about how we understand social transformations. Researchers involved in various projects funded within the NORFACE – Belmont Forum programme Transformations to Sustain
14 projects funded in transnational programme Democratic Governance in a Turbulent Age20/04/20
Grants Governance programme within NORFACE Fourteen transnational and multi-disciplinary social science research consortia have received funding from the European NORFACE network within the research programme 'Democratic governance in a turbulent age'. Over the next few years they will focus, on sub
HIGH NUMBER OF WORKING PAPERS PUBLISHED BY DIAL RESEARCH TEAMS03/04/20
HIGH NUMBER OF WORKING PAPERS PUBLISHED BY DIAL RESEARCH TEAMS First results of transnational research on inequality across the life-course While working on new research projects, researchers are generally eager to share their first results, with other scientists in the field or with a wider audienc
NORFACE DIAL Podcast Series05/02/20
The NORFACE transnational research programme "Dynamics of Inequality Across the Life-course: structures and processes" (DIAL) focuses on the complex and highly intertwined sources of inequalities in contemporary societies, and their consequences. In 2017, thirteen interdisciplinary and international
Programmes_
Democratic politics and governance in Europe are facing turbulent times. Party systems have crumbled or been substantially changed and so have citizen attachments to government, political parties and democratic procedures. This sixth NORFACE transnational programme on Democratic governance in a turb
Climate change, environmental degradation and resource pressures have created unprecedented situations for societies worldwide. Consequently, there is growing attention to the need for fundamental transformations in the way societies interact with each other and with the natural environment as the b
Existing and rising inequalities pose fundamental challenges to European societies and economies. The increasing gap between rich and poor, exacerbated by the recent financial and economic crises, is a key concern. The NORFACE transnational research programme on "Dynamics of Inequality Across the Li
The NORFACE Welfare State Futures research programme (2014-2019) was designed to ask, and answer, fundamental questions about the design, delivery and experience of welfare states in the 21st century from a wide variety of perspectives and disciplines. The programme featured a Europe-wide network of
Migration is an important topic on the European agenda due to the large-scale flows of asylum seekers. At the same time, migration has been part of Europe's history, evidenced by Europe's substantial share of immigrant (first and second generation) populations. The NORFACE transnational research pro
The NORFACE transnational research programme on "Re-emergence of Religion as a Social Force in Europe?" probed the condition of religion in Europe against the background of European secularism. Also the programme investigated the re-kindling of religious activity brought about by the political and s

redpajama_set_name: RedPajamaCommonCrawl


High quality, online and face-to-face learning for aspiring musicians.
Ever dreamed of picking up a guitar and being able to play your favourite songs, beautifully? Being able to put theory and technique into practice to create music is an ultimately satisfying experience.
At 12th Fret Tuition, we're constantly crafting new ways for you to be able to learn vital aspects of guitar technique, music theory, timekeeping and those all important licks that will make you stand out amongst other beginners.
Are you an absolute beginner? Do you want to brush up on your guitar skills or advance your playing? Do you want to learn about songwriting? I can help you to do all these things with my weekly guitar lessons.
All of our guitar tutors are, or have been, professional musicians and carry a wealth of experience.
Our course leader, Joe, is a professional guitar tutor and experienced musician, he has worked in both private and public music schools for over 10 years.
Joe has a BA Honours Degree in Popular Music and a Grade 8 Distinction in Bass Guitar and Grade 8 in Guitar and Vocals. His pupils have a 100% pass rate in their RTG exams.


text:
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redpajama_set_name: RedPajamaGithub


text:
/ Anime
My Hero Academia: Heroes Rising
One Piece: Stampede
Pokemon: Detective Pikachu
Dragon Ball Super's Goku Balloon Returning for Macy's Thanksgiving Day Parade 2019
By Nick Valdez - November 9, 2019 07:30 pm EST
Dragon Ball Super had an incredible year last year. With the anime at its peak, and the rest of Dragon Ball Super: Broly imminent, the franchise took a huge step forward as Toei Animation and Funimation debuted a brand new Super Saiyan Blue Goku balloon as a part of Macy's Thanksgiving Day Parade. It can be a surprisingly competitive venture to get a spot in the famous parade, so this was a huge breakthrough for fans of anime in general. Now history will repeat itself as the Goku balloon will be making its return for Macy's Thanksgiving Day Parade 2019.
Funimation confirmed that the Super Saiyan Blue Goku balloon will be returning to the parade for a second year in a row. Unfortunately there are no new images of the balloon just yet, but chances are it will remain relatively unchanged much like all of the other great mascot balloons in the parade.
This will cap off a strong year for Dragon Ball Super's run with Funimation as the English dub of the series ended just a few weeks ago. This will essentially be a victory lap for the famous character as fans wait on potential news for a return of the anime series. This doesn't necessarily mean one way or the other that a new anime series is in the works, but it is a great way for Dragon Ball to stay in the conversation!
There's a hope that the balloon will make just as much impact as it had made last year. As the Goku balloon fought against wind and hilarious name pronunciations, Dragon Ball fans were huge fans of seeing Super Saiyan Goku fly his way through the streets of New York City. It will without a doubt have the same amount of impact, but it's a different kind of excitement.
Dragon Ball might be over for now, but it's not exactly "over." There are future projects in the works in some capacity, and with Goku already making room for Dragon Ball characters, perhaps even more will get their balloon debut someday?
Dragon Ball Super currently airs its English dub on Adult Swim during the Toonami programming block on Saturday evenings, and is also available to stream on Funimation and Amazon Video. The Japanese-language release of the series is complete, and available to stream on FunimationNOW and Crunchyroll. The manga has chapters that can currently be read for free thanks to Viz Media, and Dragon Ball Super's big movie, Dragon Ball Super: Broly, is now available on Blu-ray and DVD.
Dragon Ball Theory Unveils the Real Reason Gohan Is Stronger Than Goku
Roland Emmerich Admits He "Didn't Want" to Make the 1998 Godzilla
Naruto Cosplay Brings A Bodypaint Version Of The Seventh To Life
How Dragon Ball Super Can Bring Bardock Back to the Series
Attack On Titan Season 4 Introduces Its Mysterious Paths


text:
Airport free phone charging stations warning after 'juice jacking' scam
One simple act there could end up costing you a lot of money, without you even realising it
Courtney Pochin
It's the start of a brand new year and many people will no doubt be planning a getaway sometime soon or for the summer.
But whenever you are travelling through the airport you might want to stay particularly vigilant especially with your phone.
That's because one simple act there could end up costing you a lot of money, without you even realising it.
According to law enforcement in the US, using public USB charging stations at airports could cause your bank account to be drained as hackers are infecting ports with malware as part of a scam known as 'juice jacking'.
Bride's honeymoon saved by 'superheroes'
All the places you could afford go on holiday if you gave up alcohol in 2020
Luke Sisak, Los Angeles deputy district attorney, explained the dangers of juice jacking in a recent video shared on his office's website, reports The Mirror.
He said: "A free charge could end up draining your bank account.
"Criminals load malware onto charging stations or tables they leave at the kiosk.
(Image: Vladimir Gerdo/TASS))
"Once the unsuspecting user plugs in, their phone or electronic device becomes infected.
Instead of using public USB ports, travellers are advised to instead use power outlets and take their own plug-in chargers and car chargers on journeys.
It may also be a good idea to keep a portable charger with you at all times.
The worst UK airports for lost luggage complaints
Travel tips for going abroad with a baby including what you can and cannot bring on a flight
Juice jacking has been an ongoing issue since 2011.
The malware that hackers use can lock you out of your device and export your passwords, addresses or potentially even a full backup of your phone to criminals.
All of this information is obtained in just a few minutes.


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Media & Tech
Best Plant-Based Proteins to Consume
Dec 17, 2016 | Diet, Lifestyle
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Some people think that going on an all plant-based diet can make them be deprived of having protein in their bodies. Fortunately, there are a lot of plant-based protein foods that people can consume, so they can still get the protein that their body needs.
One of the best things about going on a plant-based diet is that you can prepare your meal in the comfort of your home. A small garden with easy to grow vegetables, but they contain a lot of nutrients that you do not know. If you do not want to do the fertilizing, weeding, digging,… an indoor hydroponic garden will be a good choice.
So here are some of the plant-based proteins to have and how you can add them to your diet.
Beans — these are known to be the best source of fiber, carbohydrates, and protein. They are also considered as proteins that are starchy and are similar to lentils. Beans can be cooked with seasoning, used on top of salads, combine with quinoa or rice, and even as a filling for tacos. A cup of beans has 15 grams of protein.
Nuts — there are different types of nuts that you can have, such as Brazil nuts, pistachios, cashews, walnuts, and almonds. They are not only rich in proteins, but as well as healthy fats, vitamin E, and minerals. Nuts can be added as a topping for salads or for making your very own nut butter. One-fourth cup of nuts has 7 to 9 grams of protein.
Seeds — pumpkin seeds, flax, hemp, chia, sesame, and sunflowers seeds are all rich in mineral and protein. Remember that seeds come in different types, wherein there are some which have a neutral taste and there are some that are nutty. Seeds can be sprinkled on salad, and can even be used to create your very own seed butter. One-fourth cup of seeds has 7 to 9 grams of proteins.
Yeast — due to the cheesy flair that it has, it became one of the favorites of people who are on a plant-based diet. It has no active yeast nor dairy and is typically found in flake or powder form. Yeast can be added to water or your daily almost milk. It can be sprinkled on top of beans, lentils, quinoa, and even salads. Three tablespoon of yeast has 12 grams of protein.
Spirulina — it is known to composed mostly of protein. Spirulina tastes nutty and sweet; wherein it has hints of chocolate and vanilla. You can add this to your smoothies, including Beauty Green and Tropical Green smoothies. Two tablespoon of spirulina has 8 grams of protein.
Above are some of the best plant-based proteins that you can consume, for you to ensure that you will get the needed daily protein that your body needs for it to function well.
Filed under: Diet, Lifestyle
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Q: How to find the cumsum of a column? dict={"asset":["S3","S2","E4","E1","A6","A8"],
"Rank":[1,2,3,4,5,6],"number_of_attributes":[2,1,2,2,1,1],
"number_of_cards":[1,2,2,1,2," "],"cards_plus1":[2,3,3,2,3," "]}

dframe=pd.DataFrame(dict,index=[1,2,3,4,5,6],
columns=["asset","Rank","number_of_attributes","number_of_cards","cards_plus1"])

i want to do cumsum of the column "cards_plus1".
How can I do this?
the output of the column cumsum should be that:
0
2
5
8
10
13

A:
i want to start with zero instead of 2.. i want this outup : cards_plus1_cumsum 0 2 5 8 10 13

We can just pad a zero before the sums:
dframe["cumsum"] = np.pad(dframe["cards_plus1"][:-1].cumsum(), (1, 0), 'constant')

A: Try this:
First, replace the blank values by nan
import pandas as pd
import numpy as np

dict={"asset":["S3","S2","E4","E1","A6","A8"],"Rank":[1,2,3,4,5,6],"number_of_attributes":[2,1,2,2,1,1],
          "number_of_cards":[1,2,2,1,2," "],"cards_plus1":[2,3,3,2,3," "]}

dframe=pd.DataFrame(dict,index=[1,2,3,4,5,6],
columns=["asset","Rank","number_of_attributes","number_of_cards","cards_plus1"])

## replace blank values by nan
print(dframe.replace(r'^\s*$', np.nan, regex=True, inplace=True))

print (dframe)

>>> asset  Rank  number_of_attributes  number_of_cards  cards_plus1
1    S3     1                     2              1.0          2.0
2    S2     2                     1              2.0          3.0
3    E4     3                     2              2.0          3.0
4    E1     4                     2              1.0          2.0
5    A6     5                     1              2.0          3.0
6    A8     6                     1              NaN          NaN

Now the data type of the cards_plus1 column is object - change to numeric
### convert data type of the cards_plus1 to numeric
dframe['cards_plus1'] = pd.to_numeric(dframe['cards_plus1'])

Now calculate cumulative sum
### now we can calculate cumsum
dframe['cards_plus1_cumsum'] = dframe['cards_plus1'].cumsum()

print(dframe)

>>>
asset  Rank  number_of_attributes  number_of_cards  cards_plus1  \
1    S3     1                     2              1.0          2.0
2    S2     2                     1              2.0          3.0
3    E4     3                     2              2.0          3.0
4    E1     4                     2              1.0          2.0
5    A6     5                     1              2.0          3.0
6    A8     6                     1              NaN          NaN

   cards_plus1_cumsum
1                 2.0
2                 5.0
3                 8.0
4                10.0
5                13.0
6                 NaN

Instead of replacing the blank values by nan, you can replace them by zero, depends on what you want.. Hope this helped..

redpajama_set_name: RedPajamaStackExchange


Webster's Rolla Metro campus location hosted a roundtable discussion on Sept. 24 among professionals in fields whose educational credentials include degrees in counseling, human services, social work, and psychology. Those professionals discussed their educational choices and experiences, as well as their paths to their current professional career.
They also discussed how their choice of degree program and/or institution affected their career path, if/how they would change any of those decisions, and how their education prepared them for their current work.
Webster Rolla has committed itself to focus on the helping professions in its programs, activities, and involvement. It is committed to offering people a range of educational programs to help them achieve their professional goals, intent on providing many options for those people whose goals include the care or counseling of other people. The campus location is developing a broader understanding of what is deemed a "helping" profession to include certain business focuses, such as gerontology, healthcare administration, and leadership.


Emergency Room Versus Emergency Dentist?
Searching for an emergency dentist in Indianapolis, IN just got a lot easier. Emergency Dentists USA provides you with the easiest possible method of getting the next available appointment at an emergency dentist near you, all you have to do is call!
We are a referral service that will connect you to an urgent care dentist near you! Simply call our 24 hour a day, 7 day a week hotline number and we can use our connections with emergency dentists in Indianapolis to get you set up with an walk in dentist right away.
Last week I bit down on a piece of candy wrong and chipped my tooth, I was in such pain I couldn't believe it. I had no idea what to do, so I googled emergency dentists in my area and this site came up. Instead of having to call several dentists and wait for a call back, the operator helped get me in touch with a Dr. right away!
There are many instances where you will find yourself in pain on the weekends and in need of a walk in or after hours dentist. We have done extensive research and compiled a list of emergency dentists that can help in your time of need!
Walk-in clinics allow a patient to just walk in, without an appointment. The best example of this type of clinic in Indianapolis is 24 Hour Dental Care. They're open 24 hours a day, 7 days a week. On their website, they also have an option to check- in online. This is such a great feature because you can check-in and check on wait times before you even head to the clinic.
If you are looking for dental care after hours, Immediadent Urgent Dental Care and Urgent Dental Center & Family Dentistry are the best choices per our research. Immediadent Urgent Dental Care is open 9 AM to 9 PM, seven days a week and Urgent Dental Center & Family Dentistry is also open 9 AM to 9 PM, Monday through Saturday. Both clinics are excellent and are able to take care of any dental needs you may have.
Indianapolis does have a 24-hour dentist which is such great news as most cities do not. 24 Hour Dental Care is on our list below, this clinic offers emergency dental care 24 hours a day, 7 days a week, 365 days a year. This office is perfect for you if you're experiencing an emergency overnight, on weekends or even on holidays!
Description Our referral service is open 24 hours a day, 7 days a week and makes it so easy for you to connect to an emergency dentist near you. Call us and we will find a dentist that will work for you, and can even assist in setting up an appointment if it's needed. It's that simple! Easily find Indiana emergency dentists with our service.
Description: 24 Hour Dental Care is always open and always affordable! With three locations currently and a fourth on the way, this clinic is your best choice if you are experiencing tooth pain late at night, on the weekend or on holidays.
They accept most dental insurance plans, call to verify if your plan is covered.
They also offer a Dental Discount Plan and financing through CareCredit.
Description: Same day appointments and walk ins are always welcome at Immediadent Urgent Denetal Care. As a franchise within a 3-state region, this is an incredibly dependable walkin dentist practice that many students and working professionals use every day.
They also offer financing through CareCredit.
Description: If you're experiencing a toothache in the Indianapolis area, this clinic's emergency team can provide urgent care for nearly any dental emergency. With two locations and their amazing hours Monday to Saturday, you'll be sure to get an appointment quickly.
They also offer flexible payments, discount programs, and promotional offers.
What Should You Do To Prepare For Your Emergency Dental Appointment in Indianapolis?
An emergency dentist visit is very similar to a regular dental checkup. You will want to arrive 15 minutes early, if at all possible, in order to have time to fill out the necessary paperwork. This allows the Dr. and staff to have your medical information, allergies, etc in order to treat you quicker and more efficiently.
If you are in pain, please inform the front desk staff so they can get you in to see the Dr. right away.
You'll also want to have an idea on how you'll pay for your visit. Most of the emergency dental clinics accept dental insurance, but you'll want to check with the office to verify if your specific plan is covered. You can also discuss with them the forms of payment they accept, and what financing they have available, if necessary.
There are many reasons you would need to see an emergency dentist. Some of the typical reasons why you may need to see the emergency dentist are an abscess, chipped tooth, broken jaw, lost tooth, cracked or broken tooth, and damaged braces or wires. When these situations arise, you will want to contact an emergency dentist in Indianapolis and get in to see them as soon as possible.
If you suffer from a sports injury, car accident, fall, etc where there is more injury to your person than just damage to teeth, you'll want to head directly to an emergency room. They will be able to treat the other, more pressing, injuries first. Once those are treated, they will refer you to a dentist to treat the damage to your teeth the accident caused.
Emergency rooms are excellent to handle bodily injuries, however, they are not equipped to handle most dental emergencies. If you do visit an emergency room for a dental emergency only, they will likely prescribe pain medication or an antibiotic and refer you to your dentist or an emergency dentist in your area.
Indianapolis provides plenty of opportunities to see an emergency dental professional, whatever the need may be. Above we have provided a list of several dental offices that are open extended weekday and after hours, as well as weekends.
You can also let us do the work for you! Our referral service, Emergency Dentists USA, will help you find the perfect dentist to fit your needs, 24 hours a day, 7 days a week and all you have to do is make one quick call.
We also suggest checking with the local dental association to ensure the dentist of your choosing is licensed and certified. For Indiana, it is the Indiana Dental Association. You can also check a dentist's certification at the American Dental Association.


text:
Arnold Kemp
The Arnold Kemp archive
Playwright Robert Kemp (1908-1967)
Rev Arnold Low Kemp (1869-1949)
Rob Bruce Photography
18th August 2016 18th August 2016
A Wartime Escape: Another Arnold Kemp
This is an excerpt from Arnold Kemp's family memoir: "The Sentimental Tourist". It is his account of the wartime escape of another Arnold Kemp, his uncle, and the younger son of the minister in Birse who is also mentioned here, Rev Arnold Low Kemp
Uncle Arnold's escape
A REMARKABLE TALE of the war comes to us from my Uncle Arnold (Addie). Uncle Addie was also able, if less literary than his older brother (my father Robert Kemp), and an active and adventurous boy. His informal education was to prove of at least as much value as his studies in the classroom. Indeed, his childhood ploys on the Dee probably helped to save his life later. He was dux of Aboyne intermediate school and then followed my father to Robert Gordon's. He took a diploma in tropical agriculture at Marischal College (the other wing of the university) and was appointed an assistant manager of a rubber estate in the state of Kedah, North Malaya. He left in 1937 on the PO steamship Corfu and immediately joined the local volunteer force. In 1940 he moved to Perak, transferred to the Federated Malay States Volunteer Forces and began extended wartime training.
In December 1941, while he was on long leave in Sydney, the Japanese attacked Pearl Harbor and northern Malaya. He joined the Australian Imperial Forces but on his urgent recall to Malaya by the volunteer forces was granted an immediate discharge to enable him to return. He arrived in Singapore in January 1942 in the midst of a severe air raid. He was sent by train to Kuala Lumpur but it was overrun by the Japanese and he had to withdraw by stages to Singapore.
The Japanese assault forces penetrated the Singapore's island defences about the 6th or 7th of February. Their gunfire turned night into day. Addie was in charge of a section of about 10 men with two machine guns, deployed in pill boxes on the tiny island of Berhala Repin, straight across from Admiralty Steps on the Singapore sea front. Fires raged throughout the city and the harbour area. Some members of the company were killed as the Japanese strafed and bombed at will: they had total control of air space.
On Friday, February 13, two days before the fall, a party of Allied soldiers was spotted on a pier half a mile from Addie's pill box. Their company commander, Eric 'Whisky' Bruce, ordered him to take a couple of men and guide the party back to company headquarters. It was a hairy journey as Japanese planes searched for victims. Addie and his men ducked and dived, cowering in the craters with which the road was pitted. But when they reached the pier they found that the party had been cut to pieces. Bodies were spread about everywhere. They found no survivors but as they were about to leave noticed a man, half buried, who still seemed to be alive. When they pulled him free, they found that his body had been severed; 'he came away with no lower part attached'. Convulsed with nausea, they covered him as best they could and left. Later that night their nerves were again shaken when a Japanese bomb fell on a rock near Addie's pill box. A jagged boulder crashed through its concrete roof and came to rest on the lid of a full box of hand grenades.
During this week many ships were sunk in the harbour roads. Early one morning Addie saw an empty lifeboat gliding towards the pill box. He swam out to it and, grabbing its trailing painter, beached it, and secured it to an overhanging tree.
3rd February 2015 24th August 2018
Lavrenti Beria and The Collapse of the Soviet Union
A column from The Herald 1992 on an article by Donald Rayfield in the Scottish Slavonic Review.
That Lavrenti Beria was a monster is well enough known, though the full extent of his activities is still dimly understood. Apart from developing state terror as an instrument of policy, he killed and tortured personally, for the pleasure of it. He became Stalin's secret police chief. When the Soviet Union finally acknowledged its responsibility for the Katyn Massacre of 1943 – when more or less the entire Polish officer squad was wiped out by the Soviet secret police – it named Beria as the guilty man, though his recommendation was countersigned by Stalin and others.
23rd September 2014 23rd September 2014
"Were we just wrong Jim?" – Sillars and devolution
From Arnold Kemp's book, a personal history of post-war Scotland "The Hollow Drum".
…Jim Sillars told me a story about himself which, he said, explained his character. When he was 15 he was apprenticed to a plasterer and was one of a team working on a job. Although he was the junior apprentice he found he was expected to do the labouring. On further inquiry he discovered from the boss that the job had been priced to allow for three labourers, a junior apprentice, a senior apprentice and a journeyman. The boss had not employed any labourers; he was skimming more profit by making the junior apprentice do the donkey-work.
Sillars walked off the job. There was an enormous row. His father was called to a meeting. But it was to no avail and that day the plastering trade lost a recruit.
6th September 2012 6th September 2012
Crossoword tribute Herald
I APPRECIATED the tribute to the late Arnold Kemp by John McKie (alias Myops) incorporated into the Wee Stinker crossword on September 23. It was, as usual, very clever yet…
IT is one of the odd characteristics of our political life that the little things may be more dangerous than the large. Chancellor Norman Lamont may with impunity squander billions on the fruitless defence of sterling. This matters little in the public mind beside his inability to keep his Access bill inside its credit limit.
Perhaps there is some validity in this way of assessing the real person. A character in a Jane Austen novel — one of her succession of charming men who turn out to be scoundrels — was found to be of light and careless disposition because he went to London to get his haircut.
And in London this week another victim of the treacherous turns of political life was making a triumphant return. They used to call him Tricky Dick but, thin as a cheroot, he received a standing ovation from a highly discriminating audience after a speech to a private dinner. Delivered with passion and fluency, without notes of any kind, it could only be described as a tour de force.
Alex Salmond renounces SNP leadership in 2001
From The Arnold Kemp Archives: Observer,	Sunday 28 January 2001
Somewhere at home I have a collection of tapes of political interviews dating from the early 1990s. I have always meant to listen to them again, not for their substance but for the eccentric extraneous noises.
Interruptions by waiters have a deadly effect on anecdotes; they are always perfectly timed to ruin the punch-line. The chatter and laughter of fellow diners constitute other hazards.
Alex Salmond renounces SNP leadership
From The Observer,	Sunday 28 January 2001
29th March 2011 29th March 2011
Henry McLeish's resignation as First Minister
The Observer,	Sunday 27 January 2002 01.46 GMT
There is a school of newspaper writers who believe in adding culinary detail in order to satisfy the dictum of the great American journalist A.J. Liebling, who said that the first duty of the reporter was to convince the reader that he was there.
In the heyday of the Sunday Times Insight team, a great deal of manpower was expended on what was called the theory of corroborative detail. A friend recalls phoning the butler at the Hirsel in 1963 to establish just what Alec Douglas-Home had for breakfast on the morning he received the call to lead the Tories.
Tom Johnston, wartime secretary for Scotland
THE day before the premature closure of Ravenscraig was announced I chanced to be in Caledonia Books, one of the excellent second-hand bookshops in the West End of Glasgow. Among my purchases was Memories, the autobiography of Tom Johnston, Secretary of State for Scotland during the war. He is remembered today mostly for the foundation of the Hydro-Electric Board but there was more to him than that.
When Churchill summoned him to London in 1941 and persuaded him — rather against his will, for he wanted to write books — to join the national Government he made two conditions. One was that he didn't want to take any money for office during the war. "My resources are adequate to my needs and I don't want to make a song and dance about it."
Gitobu Imanyara
EVERY so often you meet a person whose courage draws you up short and makes you ashamed of your petty grievances. Sometimes the courage is private and personal; sometimes it is in the public domain. In Budapest earlier this month I had the great privilege of meeting an African who has twice come within an inch of death in the cause of freedom.
I would like to be able to claim Gitobu Imanyara as a journalist, for he is the editor of the Nairobi Law Monthly. Indeed, he is a journalist in that his magazine goes far beyond the bounds of normal legal commentary and is detested by the Kenyan regime for its exposes of corruption, brutality and malpractice. But Imanyara is really a lawyer.
A tea party in Hungary
IT is a sunny spring afternoon in Buda. At the British Embassy they are giving a tea party. The guests, the Brits attending a conference in the town, are ushered through the magnificent old mansion, dating from the great days of the Austro-Hungarian empire. They admire the circular marble staircase and the Bluthner grand piano on which recitals are given from time to time.
Geoffrey Palmer, Scotland's first black professor
ON the way back from Kelso races on Thursday the bus stopped at the little village of Oxton and our hosts got up an impromptu dominoes tournament in the pleasant little pub there. I was swiftly wiped out in the first round by one Godfrey ("Geoff") Palmer. He went on to contest the final, in which he was narrowly beaten by a senior Labour local government politician.
2nd March 2011 2nd March 2011
A defence of Malcolm Rifkind
The Herald, Editorial Notebook, 24 April 1993.
THERE appeared in the London Evening Standard, on Friday, April 16, a vicious attack on Malcolm Rifkind. It was written by a Matthew Norman. I have never heard of him and I entertain absolutely no desire ever to meet him.
The article is a critique of Mr Rifkind's considered response to pressure put on him by Lady Thatcher and others to support military intervention in former Yugoslavia.
Jimmy Logan, selling water and playing safe
The Herald, Editorial Notebook, 29 May 1993.
THE water in the Grand Canal looks filthy but the fat lady from the Bronx reclines in the gondola and trails her fingers langorously in it. This early in the year the smells are not yet ripe but the occasional pong wafts up to the restaurant where we sit in the garden as evening falls.
White Settlers
ON these sunny mornings of our Indian summer it is hard to feel bad tempered, but there are people whose behaviour can nudge you towards irritation whatever the weather. Among these, the imperious Englishwoman is a world champion.
Such thoughts occurred to me as I queued behind one of the breed at the express till at our local supermarket this week. She caught my eye because she was carefully reading the notice explaining that transactions were cash-only.
Rain in St Malo
COCO the dog is a trifle wet. His mistress has taken him on his morning walk and, because it is raining, chained him to a banister rail until he dries and can resume his usual place on a settee. For most of his life the boxer, grave and dignified, has sat around the lobby of the hotel and watched the tourists come and go. They pet him still.
1st March 2011 1st March 2011
NELSON Mandela joins us for a working breakfast though, at 8am, he has already eaten. He does not look his 75 years, and he speaks to the journalists, with energy and conviction, for more than an hour. Our breakfast sits unnoticed on the side table.
Pat Chalmers and the BBC
Pat Chalmers, controller of BBC Scotland between 1983 and 1991, has retired from the corporation after a two-year stint in Hong Kong, and this week friends and colleagues attended a dinner given for him in London.
Pat belonged to an era of broadcasting that seems now to be disappearing. Both in the Birtian BBC and in the commercial world increasingly ruled by market forces, it would now be difficult for an independent and rumbustious spirit like Pat to survive.
ACROSS the Ness from the hotel policeman keep watch from the roof of the Eden Court Theatre where the Tory conference is in session. The Prime Minister is arriving shortly to bring this melancholy but oddly inspiring week in British politics to a conclusion.
It has been melancholy, of course, because of the cruel death of John Smith. In its grief the British political establishment has found a rare unity. Our adversarial system has the virtue of in the end producing a Yes or a No to any political question. Its defect is that its perpetual mutual slagging becomes arid. The prying eyes of television, and the eavesdropping radio microphones, have revealed also its petty, schoolboy side.
ONCE, during a short season on the staff of the old North British Hotel in Edinburgh, I took up in the lift such notables as Gene Kelly, Kenneth More, and Sir Arthur Bliss. Quite apart from acquiring a lasting appreciation of the patience of those who have to wait on the public, and a tendency, out of a lingering feeling of solidarity, to tip too much, I have been dining out on my days as a lift boy ever since.
Glamour rubs off on those who find themselves close to it but celebrity is a two-way street. This week in Edinburgh, a tourist in my own home town, shuttling about the place as a consumer of culture, I have again seen this truth at work.
The Arnold Kemp Archives
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Egyptian President Mohammed Morsi says that there will be no further privatization of state-owned companies.
Egypt's economy is hard hit by the more than two years of turmoil since the ouster of longtime president Hosni Mubarak in a mass uprising in 2011. Losses to the vital tourism sector have depleted government revenues and public sector companies are an additional burden on the budget.
In a Tuesday speech on the eve of May Day, Morsi — an Islamist from the Muslim Brotherhood group — said there would be no selling of the public sector. He did not specify whether this was a temporary or permanent measure.
Egypt privatized key companies in the 1990s under Mubarak but the program stalled in recent years. Critics say the sales were tainted by corruption.


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COVID-19 patient outcomes affected by cardiovascular risk
UTSW researchers present findings at American Heart Association Scientific Sessions 2020
Credit: UT Southwestern Medical Center
DALLAS – Nov. 17, 2020 – Research presented today by UT Southwestern cardiologists at the annual American Heart Association (AHA) Scientific Sessions 2020 showed that Black and Hispanic people were more likely to be hospitalized with COVID-19 than white patients, and that nonwhite men with cardiovascular disease or risk factors were more likely to die.
In one of the conference's late-breaking research sessions, James de Lemos, M.D., a professor of internal medicine who holds a distinguished chair in cardiology at UTSW, discussed COVID-19 Cardiovascular Disease Registry: Design, Implementation, and Initial Results.
The American Heart Association COVID-19 Cardiovascular Disease Registry was created by volunteers and AHA staff and launched in the spring at the outset of the pandemic. To date, the registry has gathered records on more than 22,500 patients from 109 U.S. health care centers in 34 states, including data points on patient demographics, cardiovascular risk factors, comorbidities, medications prior to admission, treatments during hospitalization, disease severity measures, and laboratory results.
In a related study, Racial and Ethnic Differences in Treatment and Outcomes for Patients Hospitalized with COVID-19: Findings from the American Heart Association COVID-19 Cardiovascular Disease Registry, deLemos and his team studied 8,000 COVID-19 patients who were hospitalized from Jan. 17 to July 22. This group was treated at 88 hospitals. One-third were Hispanic, 25.5 percent were non-Hispanic Black, 6.3 percent were Asian, and 35.2 percent were non-Hispanic white. Black patients were younger with higher rates of obesity, high blood pressure, and diabetes, and were also more likely to require a ventilator or kidney dialysis than white patients.
"The results highlight the disproportionate burden of COVID-19 among Black and Hispanic patients, and imply there are factors in the U.S. that existed prior to hospitalization that are driving these disparities in COVID hospitalization and death," says de Lemos, who served as co-chair of the steering committee for the registry.
In another late-breaking session, Ann Marie Navar, M.D., Ph.D., reported that a review of nearly 20,000 patients revealed that cardiovascular disease or CVD risk factors in COVID-19 patients dramatically increased the risk of in-hospital mortality. The risk of death was particularly high for older, nonwhite men.
Navar's research team studied electronic health records from 54 health systems that use a COVID-19 database provided by Cerner, a health information technology firm. The results, measured from January to May and shared in "Impact of Cardiovascular Disease on Outcomes Among Hospitalized COVID-19 Patients: Results From >14,000 Patients Across the U.S.," showed that in-hospital mortality ranged from 28.5 percent for patients with hypertension to 28.6 percent for those with diabetes, 25.5 percent for those with coronary artery disease, and 38.4 percent for those with heart failure.
Just 1.5 percent of the patients had a stroke while hospitalized for COVID-19, but the mortality rate was 56 percent among this group. Similarly, 5 percent of patients had a heart attack, and 55.5 percent of these individuals died during their hospital stay.
"These data reflect what doctors and nurses on the front lines in hospitals across the U.S. are actually seeing, where more than 1 in 15 patients hospitalized with COVID-19 does not make it home," says Navar. She conducted the research at the Duke Clinical Research Institute before joining UT Southwestern as an associate professor of internal medicine and population and data sciences.
The American Heart Association's Scientific Sessions, held virtually this year Nov. 13-17, presented the latest advancements, research, and evidence-based clinical practice updates in cardiovascular science for health care worldwide.
At UT Southwestern, de Lemos holds the Sweetheart Ball-Kern Wildenthal, M.D., Ph.D. Distinguished Chair in Cardiology.
Navar is a consultant for Cerner and is an uncompensated research principal investigator with the firm.
About UT Southwestern Medical Center
UT Southwestern, one of the premier academic medical centers in the nation, integrates pioneering biomedical research with exceptional clinical care and education. The institution's faculty has received six Nobel Prizes, and includes 23 members of the National Academy of Sciences, 17 members of the National Academy of Medicine, and 13 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,500 is responsible for groundbreaking medical advances and is committed to translating science-driven research quickly to new clinical treatments. UT Southwestern physicians provide care in about 80 specialties to more than 105,000 hospitalized patients, nearly 370,000 emergency room cases, and oversee approximately 3 million outpatient visits a year.
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Author(s): Catherine L. Cherry, Jennifer F. Hoy, James S. Rowe, Henry Krum, John Mills, Sharon R. Lewin. Burnet Institute. PO Box 2284, Melbourne 3001, Victoria, Australia.
DG17 is an orally available prodrug of DG35 (a novel HIV protease inhibitor with variable pharmacokinetics). These studies aimed to optimize DG17 pharmacokinetics by gastric acid neutralization and ritonavir pharmacoenhancement. Both studies were conducted using a randomized, cross-over design in which 6 healthy individuals were administered a single dose of 100mg or 200mg DG17, half with the study intervention (sodium bicarbonate solution in the first study, low dose ritonavir in the second). After a one week washout period, each subject was then administered a second dose of DG17, with the study intervention only administered to the other half. Cmax and AUC increases with gastric acid neutralization were greatest in those with the lowest absorption of DG17 alone. All doses were subsequently given with sodium bicarbonate solution in the second study. Low-dose ritonavir co-administration with DG17 increased DG35 Cmax (median 1437 versus 100 ng/ml, p=0.028) and AUC (median 6975 versus 154ng/ml*hr, p=0.028) compared with DG17 without ritonavir. Plasma DG35 exceeded the IC90 for HIV for ≥ 12 hours following a single DG17/ritonavir dose. No significant adverse events occurred. Single dose DG17 is safe and best administered in a manner preventing gastric acid degradation and with low-dose ritonavir.
Affiliation:Burnet Institute. PO Box 2284, Melbourne 3001, Victoria, Australia.
Abstract: DG17 is an orally available prodrug of DG35 (a novel HIV protease inhibitor with variable pharmacokinetics). These studies aimed to optimize DG17 pharmacokinetics by gastric acid neutralization and ritonavir pharmacoenhancement. Both studies were conducted using a randomized, cross-over design in which 6 healthy individuals were administered a single dose of 100mg or 200mg DG17, half with the study intervention (sodium bicarbonate solution in the first study, low dose ritonavir in the second). After a one week washout period, each subject was then administered a second dose of DG17, with the study intervention only administered to the other half. Cmax and AUC increases with gastric acid neutralization were greatest in those with the lowest absorption of DG17 alone. All doses were subsequently given with sodium bicarbonate solution in the second study. Low-dose ritonavir co-administration with DG17 increased DG35 Cmax (median 1437 versus 100 ng/ml, p=0.028) and AUC (median 6975 versus 154ng/ml*hr, p=0.028) compared with DG17 without ritonavir. Plasma DG35 exceeded the IC90 for HIV for ≥ 12 hours following a single DG17/ritonavir dose. No significant adverse events occurred. Single dose DG17 is safe and best administered in a manner preventing gastric acid degradation and with low-dose ritonavir.


All 18" 19" 20" 17" 15" 16" 21" 22"
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G.M.P. GROUP is a company specialising in the design and mass production of high-quality aluminium components for the automotive industry on an international level, with a special focus and experience in the field of light alloy wheels. Today after more than 15 years of activity, the GMP italia alloy wheels are increasingly becoming major players on the market, in terms of design and quality and of presence on a national and international level.
Finance from £8 per month.


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Q: Progressive Loading / LOD / Streaming Mesh in Three.js I am loading stl files into a three.js scene using the STL loader. These stl files range from 5mb to 50mb.
Is there a method I can use to progressively load/stream/increase level of detail (not sure of the correct terminology) as the model loads so that my users aren't staring at a blank screen for minutes before anything appears?
If the model is 20,000 triangles, does three.js have a method for maybe loading only 2,000 first and then progressing to the fully detailed model?

A: The best solution for this is currently Nexus, which has been under intensive development in the last couple of years. It has a loader for threejs.

A: Real progressive loading / mesh streaming is not there out of the box. It would be great though and is doable.
It has been done with WebGL without three.js using POP buffers: http://x3dom.org/pop/ & https://github.com/thibauts/pop-buffer
One of the demos is: http://x3dom.org/pop/happy.html
I hope one day we'll have nice POP buffer (or similar alternative) progressive loading for three.js too -- is in my/our todo / wish list too but many things still before that here .. sure don't mind if someone writes it earlier :)
Three does include a simple LOD mechanism but it is to help with rendering load and not with loading time: http://threejs.org/docs/#Reference/Objects/LOD & http://threejs.org/examples/webgl_lod.html
For a simple solution, you could author low & high versions of your models and write custom loading logic to just first load the low one & show them, then proceed to load the high version etc.
We've done that in one project, works fine as expected. Only downside I can figure is that it increases the total time to get the high version. But the low can be very small so it's ok (in our case low poly untextured with just vert colours, then the high ones have much more polys but essentially quite big textures too).

A: Nexus and popbuffer could be the right solutions for prograssive LoD loading. However if you just want to try a simple (just working) solution, suggest to have a look into this:
https://github.com/amd/rest3d
On basis of GLTF format, it transmits single mesh one by one. In a certain sense it reduces the waiting time for the first renderring. Actually if you rearrange mesh data and use streaming buffer to download data, you might achieve a result of prograsive loading/rendering.