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Alternative to animal experiments - 21/03/2018
Drug tests using miniature organs
At present, potential new drugs have to be tested on animals before they can be used on humans. However, results obtained from animals are not always transferrable to the situation in humans, which is why researchers around the world have long been seeking alternatives. Miniature human organs that can be used to test the efficacy of potential human drugs might provide a solution.
https://www.gesundheitsindustrie-bw.de/en/article/news/drug-tests-using-miniature-organs
Press release - 12/12/2017
BRAIN AG and Mannheim University develop 3D skin models for health care and cosmetics
Research collaboration in project M2Aind for new real-time and high-resolution screening technologies of 3D skin spheroids. Mannheim University of Applied Sciences builds on expertise in 3D cell culture and advanced live cell imaging. BRAIN contributes unique skin reporter cells, screening compound libraries and market knowledge. Review article in Journal of Cellular Biotechnology.
https://www.gesundheitsindustrie-bw.de/en/article/press-release/brain-ag-and-mannheim-university-develop-3d-skin-models-for-health-care-and-cosmetics
Article - 07/12/2017
GoSilico: a formula for the industrial purification of biomolecules
"Stop experimenting – GoSilico" is the motto of a young start-up company from Karlsruhe. The founding team of GoSilico GmbH is causing a furore with a simulation software that would make many laboratory experiments obsolete. The chromatographic separation of biomolecules from organisms, samples and cell cultures can be reliably simulated after just a few starter experiments. This saves time, work, material and costs in pharmaceutical development.
https://www.gesundheitsindustrie-bw.de/en/article/news/gosilico-a-formula-for-the-industrial-purification-of-biomolecules
Eric Gottwald: innovative 3D cell culture systems for pharmaceutical testing
Realistic alternatives to animal testing are more in demand than ever, especially in the drug development field. One possible solution is 3D cell cultures that possess the characteristics of the tissue from which they originate. Such systems were already developed at the Karlsruhe Institute of Technology (KIT) many years ago. Due to the huge demand for such systems, Prof. Dr. Eric Gottwald and two of his colleagues founded a company called…
https://www.gesundheitsindustrie-bw.de/en/article/news/eric-gottwald-innovative-3d-cell-culture-systems-for-pharmaceutical-testing
SÜDPACK: a great example of biotech as a cross-sectoral technology
SÜDPACK Verpackungen is a qualified supplier of plastic films to the biopharmaceutical industry. The company is the leading European manufacturer of packaging products for the food industry and also offers its expertise to the biopharmaceutical industry. In 2011, SÜDPACK created an exclusive cooperation partnership with Sartorius Stedim Biotech, a global technology provider for the pharmaceutical biotech industry, which has now been extended…
https://www.gesundheitsindustrie-bw.de/en/article/news/suedpack-a-great-example-of-biotech-as-a-cross-sectoral-technology
High-Tech Gründerfonds (HTGF) invests in Reutlingen-based SIGNATOPE GmbH – Safe medications thanks to new test procedures
High-Tech Gründerfonds is investing EUR 600,000 in Reutlingen-based SIGNATOPE GmbH. SIGNATOPE will use the funds to advance the development of its unique biomarker assay system, that has been established to support pharmaceutical research. The technology is based on special antibodies and allows the early detection of possible side effects during the drug development process. Thereby, the need for animal testing will be reduced while the drug…
https://www.gesundheitsindustrie-bw.de/en/article/press-release/high-tech-gruenderfonds-htgf-invests-in-reutlingen-based-signatope-gmbh-safe-medications-thanks-to-new-test-procedures
World Day for Laboratory Animals
On 24 April 2017 is "World Day for Laboratory Animals" – the BIOPRO provides information about this topic. In Baden-Württemberg alone, up to 600,000 animals are used for scientific purposes every year. In order to reduce their pain and suffering as much as possible, researchers all over the world are working on the development of innovative methods to replace animal experiments, including cell culture methods for drug analysis,…
https://www.gesundheitsindustrie-bw.de/en/article/news/world-day-for-laboratory-animals
Imaging flow cytometry – introducing a new era of imaging
High-resolution images or quantifiable results? Up until now, researchers usually had to choose. All this has now changed thanks to a single device known as an imaging flow cytometer that combines fluorescence microscopy and flow cytometry. The new device gives new insights into complex biological phenomena in cells. It is available for research purposes at the Research Centre for Women's Health at the University Hospital of Tübingen, which…
https://www.gesundheitsindustrie-bw.de/en/article/news/imaging-flow-cytometry-introducing-a-new-era-of-imaging
Freiburg researchers transform skin cells into renal cells
A team of researchers from Freiburg has used direct programming to successfully produce kidney-like cells very similar to natural renal tubular cells in terms of appearance and function. These cells are thus a promising alternative to kidney cells isolated from animals and cells differentiated from embryonic stem cells. The reprogrammed kidney cells can be used, for example, for pharmacological and toxicological tests and investigating the…
https://www.gesundheitsindustrie-bw.de/en/article/news/freiburg-researchers-transform-skin-cells-into-renal-cells
Cancer Medications Learn to Hide
The European Research Council awards Wilfried Weber an ERC Proof of Concept Grant. Wilfried Weber, Professor of Synthetic Biology at the University of Freiburg, has received a grant of roughly €150,000 for his project "Hide and Seek with Cancer Drugs" in which he is working to improve the drugs used in cancer treatment.
https://www.gesundheitsindustrie-bw.de/en/article/press-release/cancer-medications-learn-to-hide
Cellendes and EU partners develop cell therapy for treating type 1 diabetes
Cells derived from suitable donor stem cells that can do the work defective insulin-producing cells can no longer do are the central focus of a European cell therapy project involving Reutlingen-based Cellendes GmbH as one of the partners. Cellendes develops a biomaterial that facilitates the mass production of cells and could potentially be approved for therapeutic use in humans.
https://www.gesundheitsindustrie-bw.de/en/article/news/cellendes-und-eu-partner-entwickeln-zelltherapie-fuer-diabetes-typ-1
Company profile - 25/07/2016
300MICRONS: 3D cell culture solutions tailored to customer needs
What happens in tissues and organs and how do they react to pharmaceutical substances? Three-dimensional cell cultures can reproduce reality far better than a single-cell layer can. With good reason. Reality is far from two-dimensional. A company called 300MICRONS GmbH develops films with tiny indentations that provide optimal conditions for cells to grow into 3D cell aggregates.
https://www.gesundheitsindustrie-bw.de/en/article/news/300microns-3d-cell-culture-solutions-tailored-to-customer-needs
Epigenetic modifications for the treatment of oesophageal cancer
Oesophageal cancer is a rare but highly aggressive type of cancer with a rather poor prognosis. Dr. Theresa Ahrens, a researcher in a group led by Prof. Dr. Silke Laßmann and Prof. Dr. Martin Werner at the Institute of Clinical Pathology at the Freiburg University Medical Centre, has tested a variety of epigenetic drugs that can interfere with the development of oesophageal cancer.
https://www.gesundheitsindustrie-bw.de/en/article/news/modifikation-epigenetic-modifications-for-the-treatment-of-oesophageal-cancer-als-therapie-bei-speiseroehrenkrebs
A nasal spray for treating neurodegenerative diseases
Neuroscientists from Heidelberg have created the scientific foundations for a nasal spray that can stabilise the dendrites of nerve cells, thus reducing nerve damage and brain function losses following a stroke. Prof. Dr. Hilmar Bading and his team received the 2016 German BioRegions Innovation Prize for their invention and have set up a company called FundaMental Pharma to further accelerate the development of a marketable medicinal product.
https://www.gesundheitsindustrie-bw.de/en/article/news/a-nasal-spray-for-treating-neurodegenerative-diseases
Microfluidic biofermenter mimics plant tissue
It is estimated that as many as one million secondary plant metabolites can be used as medical agents. Plants produce these compounds to aid their growth and development as well as to discourage herbivores from eating them. However, it is still very difficult, or even impossible, to produce secondary plant metabolites industrially. Researchers from the Karlsruhe Institute of Technology (KIT) are now developing a microfluidic bioreactor to make…
https://www.gesundheitsindustrie-bw.de/en/article/news/microfluidic-biofermenter-mimics-plant-tissue
Dossier - 14/06/2016
CRISPR/Cas – genome editing is becoming increasingly popular
The number of publications and patents that involve the CRISPR/Cas system has been increasing exponentially since the technique was first described a few years ago. The increase in funding for projects involving CRISPR/Cas also demonstrates how powerful this new method is. The targeted modification of genomes (also called gene editing or genome editing) using CRISPR/Cas is extraordinarily accurate and also has the potential to cure hereditary…
https://www.gesundheitsindustrie-bw.de/en/article/dossier/crisprcas-genome-editing-is-becoming-increasingly-popular
Inhibition of bromodomain affects stem cell differentiation
DNA methylation and histone modification are epigenetic mechanisms that affect gene transcription. Moreover, protein complexes can regulate gene expression by modifying chromatin structure and function. Dr. Thomas Günther and his team from the Center for Clinical Research at the Freiburg University Medical Center are studying the effect of the inhibitor PFI-3 on the BAF complex. This protein complex modifies chromatin structure and controls the…
https://www.gesundheitsindustrie-bw.de/en/article/news/nhibition-of-bromodomain-affects-stem-cell-differentiation
Microglial cells – the health police of Alzheimer's
It starts with memory loss and disorientation. Alzheimer's disease is the most common type of dementia and is characterised by the loss of neurons and synapses in the brain resulting from the aggregation of beta amyloid protein fragments into fibrils and plaques. Prof. Dr. Knut Biber and his team from the Division of Molecular Psychiatry at Freiburg University Medical Center have analysed these plaques in an in vivo-like cell culture system. They…
https://www.gesundheitsindustrie-bw.de/en/article/news/microglial-cells-the-health-police-of-alzheimers
Venneos: technology that looks at cells differently
The images of living cells that Venneos GmbH delivers are quite different from those captured by light microscopes. This is because the company, which was established in 2014, uses semi-conductors rather than optical lenses, thus opening up entirely new ways to analyse cells.
https://www.gesundheitsindustrie-bw.de/en/article/news/venneos-technology-that-looks-at-cells-differently
Autranomics – high-throughput cell production
Manual work is out – the rapid production of cells that carry foreign genetic material for use in research and industry can only be achieved with a high degree of automation. A fully automated process is needed to cultivate, analyse and select the cells. One such automated system has been developed by the Fraunhofer Society and the Max Planck Society in a collaborative project called Autranomics.
https://www.gesundheitsindustrie-bw.de/en/article/news/autranomics-high-throughput-cell-production
Cellca geared for further growth following acquisition by Sartorius
Sartorius Stedim Biotech (SSB), a leading international supplier to the pharmaceutical and biotechnology industries, acquired Laupheim-based Cellca GmbH on 1st July 2015. Walter Pytlik talked to Cellca CEO Hugo de Wit, who has been at the helm of the company since 2010, the first two years jointly with Dr. Aziz Cayli, about the background to the change of ownership and the consequences it will have.
https://www.gesundheitsindustrie-bw.de/en/article/news/cellca-geared-for-further-growth-following-acquisition-by-sartorius
3D cell culture model for more efficient tumour research
The development of anti-cancer drugs is a lengthy process because results obtained in vitro in the laboratory often differ from what then occurs in a living organism. A group of researchers led by Prof. Dr. Margareta Müller at the Furtwangen University of Applied Sciences is therefore developing a new cell culture model that adjusts in vitro to real conditions.
https://www.gesundheitsindustrie-bw.de/en/article/news/3d-cell-culture-model-for-more-efficient-tumour-research
3D bioprinting: replicating the shape of bone parts
Prof. Dr. Günter Finkenzeller, head of the Research and Tissue Engineering Laboratory in the Department of Plastic and Hand Surgery at the Freiburg University Medical Centre, and Dr. Peter Koltay from the Department of Microsystems Engineering (IMTEK) at the University of Freiburg, are being given German Research Foundation (DFG) funds for a period of three years to develop a 3D printing technique for functional bone tissue containing blood…
https://www.gesundheitsindustrie-bw.de/en/article/news/3d-bioprinting-replicating-the-shape-of-bone-parts
cytena GmbH facilitates the separation of single cells
cytena GmbH, a start-up company which was spun out from the Department of Microscystems Engineering (IMTEK) at the University of Freiburg in 2014, has developed a device that enables single cells to be deposited safely and gently using a single-cell printer called cy-Clone. Once processed, the cells can be used to study tumour heterogeneity and to create clonal cell lines for producing antibodies.
https://www.gesundheitsindustrie-bw.de/en/article/news/cytena-gmbh-facilitates-the-separation-of-single-cells
Rentschler Biotechnologie invests in new production plant
The Laupheim-based contract manufacturer Rentschler Biotechnologie GmbH is greatly expanding its production capacities. The company is investing €24 million in the construction of two 3,000 litre stainless steel bioreactors, which should be operational in early 2017 and will more than double the production capacities for cell culture-derived proteins. Rentschler also announced recently that it was adding a new 2,000 litre single-use bioreactor…
https://www.gesundheitsindustrie-bw.de/en/article/news/rentschler-biotechnologie-invests-in-new-production-plant
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Democrats in the House would be better off ending the session now and hitting the campaign trail to save their threatened jobs, says Rep. John Tanner, D-Tenn. Tanner, the leading House moderate among Democrats, is retiring after 11 terms in office, according to a Rollcall report.
Democrats are contemplating a vote on Bush era tax cuts, but given "the Senate's inability to come to grips with anything," they'd be better off leaving town, Tanner tells Roll Call.
Rep. Elijah Cummings, D-Md., the chair of the House Oversight Committee, said Friday that the House may weight impeachin . . .
Watergate journalists Bob Woodward and Carl Bernstein Friday said they have concerns after the release of special counse . . .


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Issue #28 - Hybrid Unsupervised Machine Translation
Dr. Patrik Lambert
In Issue #11 of this series, we first looked directly at the topic of unsupervised machine translation - training an engine without any parallel data. Since then, it has gone from a promising concept, to one that can produce effective systems that perform close to the level of fully supervised engines (trained with parallel data). The prospect of building good MT engines with only monolingual data has a tremendous potential impact since it opens up possibilities of applying MT in many new scenarios, particularly for low-resource languages,
The growing interest in this topic has been reflected in this blog, as this issue is actually the fourth article that deals with the idea, even dating back before Issue #11. This week, we'll give a quick recap of what has been done, before we take a look at the paper by Artetxe et. al. (2019), which proposes an effective approach to build an unsupervised neural MT engine initialised by an improved phrase-based unsupervised MT engine.
When translating in a direction in which there is no parallel training data, the usual approach was pivoting. For example, to translate from Spanish to French, pivoting used a sequence of Spanish-English and English-French engines.
In Issue #6, we talked about zero-shot NMT. Johnson et al. (2017) removed the need of pivoting with a multilingual NMT system, trained from multiple languages at the same time. For example, a system trained with only Spanish-English and English-French data was able to translate from Spanish to French. However, the resulting Spanish-French engine was relatively poor. This system was improved by Sestorain et al. (2018) with dual NMT learning He et al. (2016). In dual NMT, two machine translation systems are trained jointly, one from the source language to the target language and another from the target language to the source language. These two MT systems are improved in a loop in which the optimisation objective relies on monolingual data. A source sentence is translated into the target language, and the translation is translated back into the source language. The optimisation score is based on the fluency of the translation (in the target language) and the similarity of the initial source sentence with the translation of the translation.
In Issue #11, we took a look at the system proposed by Lample et al. (2018). This is one of the first unsupervised neural MT systems proposed (with the one by Artetxe et al., 2018). These systems have the following common points:
They are initialised with pre-trained cross-lingual word embeddings. These cross-lingual embeddings may be trained by adversarial training or a bilingual dictionary (built manually or induced automatically). They are used to build initial MT systems in source-target and target-source directions.
The initial MT systems are improved in a loop similar to the dual NMT one, with a training objective based on a language model (measuring fluency) score and a cycle translation score (from source to target and back to source). At the beginning of the training loop, phrase-based SMT systems are more performant than NMT systems.
In Issue #25, we saw how this approach was improved with cross-language model pre-training. In this case, not only the cross-lingual word embeddings are pre-trained, but also the whole initial encoder and decoder (Lample et. al., 2019).
The system proposed by Artetxe et. al. (2019) still initialises the system with cross-lingual word embeddings, but enhances the dual MT loop (point 2) by improving the phrase-based SMT systems used and progressively substitute these with NMT engines.
Improved Unsupervised SMT
Artetxe et. al. improve in three aspects the SMT systems used in the cycle translation loop. Firstly, they enhance the translation model with direct and inverse character-based similarity, in addition to the phrase translation and lexical weighting probabilities. This is because the initial system, based on cross-lingual word embeddings trained on the contexts in which the words appear, may mix up proper nouns appearing in similar contexts (for example: "Sunday Telegraph" and "The Times of London"). Secondly, the models are tuned with a modified procedure based on a monolingual objective (similar to the dual MT one). Thirdly, the training of phrase tables, performed with back-translated data (authentic target and synthetic source data or reversely), is improved. Source-target and target-source back-translated data are combined to allow probabilities to be estimated only on authentic data.
NMT hybridisation
In this work, in the dual MT training loop, the models are updated via a synthetic parallel corpus obtained by back-translation. In the first iteration, the synthetic parallel corpus is obtained entirely with the SMT system. At each iteration, more sentences are back-translated with NMT systems until the synthetic corpus is entirely generated by the NMT engines. This progressive hybridisation yields large BLEU score improvements.
Artetxe et. al. achieve results comparable to those of Lample et. al. (2019). These results compare to the state of the art of supervised MT in 2014.
Unsupervised Neural MT is already becoming a reality, and it is now doing as well as supervised MT was doing five years ago. This opens an avenue for applying MT in scenarios in which no parallel data are available which, if you ask practitioners and enterprise users who need to support many languages, is a big deal!

redpajama_set_name: RedPajamaCommonCrawl


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Citing Medicine: The NLM Style Guide for Authors, Editors, and Publishers is the style guide of the United States National Library of Medicine (NLM). Its main focus is citation style and bibliographic style. The citation style of Citing Medicine is the current incarnation of the Vancouver system, per the References > Style and Format section of the ICMJE Recommendations (formerly called the Uniform Requirements for Manuscripts Submitted to Biomedical Journals). Citing Medicine style is the style used by MEDLINE and PubMed.

The introduction section of Citing Medicine explains that "three major sources are utilized in compiling Citing Medicine: the MEDLARS Indexing Manual of the National Library of Medicine (NLM); pertinent NISO standards, primarily ANSI/NISO Z39.29-2005 Bibliographic References; and relevant standards from the International Organization for Standardization (ISO), primarily ISO 690 Documentation - Bibliographic References."

References

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Diagnosis-Dependent Relationships between Cytokine Levels and Survival in Patients Admitted for Surgical Critical Care
Tjasa Hranjec, Brian R. Swenson, Lesly A. Dossett, Rosemarie Metzger, Tanya R. Flohr, Kimberley A. Popovsky, Hugo J. Bonatti, Addison K. May, Robert G. Sawyer
Background: Death after trauma, infection, or other critical illness has been attributed to unbalanced inflammation, in which dysregulation of cytokines leads to multiple organ dysfunction and death. We hypothesized that admission cytokine profiles associated with death would differ based on admitting diagnosis. Study Design: This 5-year study included patients admitted for trauma or surgical intensive care for more than 48 hours at 2 academic, tertiary care hospitals between October 2001 and May 2006. Cytokine analysis for interleukin (IL)-1, -2, -4, -6, -8, -10, -12, interferon-γ, and tumor necrosis factor (TNF)-α was performed using ELISA on specimens drawn within 72 hours of admission. Mann-Whitney U test was used to compare median admission cytokine levels between alive and deceased patients. Relative risks and odds of death associated with admission cytokines were generated using univariate analysis and multivariate logistic regression models, respectively. Results: There were 1,655 patients who had complete cytokine data: 290 infected, nontrauma; 343 noninfected, nontrauma; and 1,022 trauma. Among infected patients, nonsurvivors had higher median admission levels of IL-2, -8, -10, and granulocyte macrophage-colony stimulating factor; noninfected, nontrauma patients had higher IL-6, -8, and IL-10; and nonsurviving trauma patients had higher IL-4, -6, -8, and TNF-α. IL-4 was the most significant predictor of death and carried the highest relative risk of dying in trauma patients, and IL-8 in nontrauma, noninfected patients. In infected patients, no cytokine independently predicted death. Conclusions: Cytokine profiles of certain disease states may identify persons at risk of dying and allow for selective targeting of multiple cytokines to prevent organ dysfunction and death.
Journal of the American College of Surgeons
https://doi.org/10.1016/j.jamcollsurg.2009.12.042
10.1016/j.jamcollsurg.2009.12.042
Dive into the research topics of 'Diagnosis-Dependent Relationships between Cytokine Levels and Survival in Patients Admitted for Surgical Critical Care'. Together they form a unique fingerprint.
Critical Care Medicine & Life Sciences 100%
Cytokines Medicine & Life Sciences 70%
Tumor Necrosis Factor-alpha Medicine & Life Sciences 17%
Granulocyte-Macrophage Colony-Stimulating Factor Medicine & Life Sciences 13%
Hranjec, T., Swenson, B. R., Dossett, L. A., Metzger, R., Flohr, T. R., Popovsky, K. A., Bonatti, H. J., May, A. K., & Sawyer, R. G. (2010). Diagnosis-Dependent Relationships between Cytokine Levels and Survival in Patients Admitted for Surgical Critical Care. Journal of the American College of Surgeons, 210(5), 833-844. https://doi.org/10.1016/j.jamcollsurg.2009.12.042
Diagnosis-Dependent Relationships between Cytokine Levels and Survival in Patients Admitted for Surgical Critical Care. / Hranjec, Tjasa; Swenson, Brian R.; Dossett, Lesly A.; Metzger, Rosemarie; Flohr, Tanya R.; Popovsky, Kimberley A.; Bonatti, Hugo J.; May, Addison K.; Sawyer, Robert G.
In: Journal of the American College of Surgeons, Vol. 210, No. 5, 05.2010, p. 833-844.
Hranjec, T, Swenson, BR, Dossett, LA, Metzger, R, Flohr, TR, Popovsky, KA, Bonatti, HJ, May, AK & Sawyer, RG 2010, 'Diagnosis-Dependent Relationships between Cytokine Levels and Survival in Patients Admitted for Surgical Critical Care', Journal of the American College of Surgeons, vol. 210, no. 5, pp. 833-844. https://doi.org/10.1016/j.jamcollsurg.2009.12.042
Hranjec T, Swenson BR, Dossett LA, Metzger R, Flohr TR, Popovsky KA et al. Diagnosis-Dependent Relationships between Cytokine Levels and Survival in Patients Admitted for Surgical Critical Care. Journal of the American College of Surgeons. 2010 May;210(5):833-844. https://doi.org/10.1016/j.jamcollsurg.2009.12.042
Hranjec, Tjasa ; Swenson, Brian R. ; Dossett, Lesly A. ; Metzger, Rosemarie ; Flohr, Tanya R. ; Popovsky, Kimberley A. ; Bonatti, Hugo J. ; May, Addison K. ; Sawyer, Robert G. / Diagnosis-Dependent Relationships between Cytokine Levels and Survival in Patients Admitted for Surgical Critical Care. In: Journal of the American College of Surgeons. 2010 ; Vol. 210, No. 5. pp. 833-844.
@article{ca018e6371624df0901e0dd97e63c3ee,
title = "Diagnosis-Dependent Relationships between Cytokine Levels and Survival in Patients Admitted for Surgical Critical Care",
abstract = "Background: Death after trauma, infection, or other critical illness has been attributed to unbalanced inflammation, in which dysregulation of cytokines leads to multiple organ dysfunction and death. We hypothesized that admission cytokine profiles associated with death would differ based on admitting diagnosis. Study Design: This 5-year study included patients admitted for trauma or surgical intensive care for more than 48 hours at 2 academic, tertiary care hospitals between October 2001 and May 2006. Cytokine analysis for interleukin (IL)-1, -2, -4, -6, -8, -10, -12, interferon-γ, and tumor necrosis factor (TNF)-α was performed using ELISA on specimens drawn within 72 hours of admission. Mann-Whitney U test was used to compare median admission cytokine levels between alive and deceased patients. Relative risks and odds of death associated with admission cytokines were generated using univariate analysis and multivariate logistic regression models, respectively. Results: There were 1,655 patients who had complete cytokine data: 290 infected, nontrauma; 343 noninfected, nontrauma; and 1,022 trauma. Among infected patients, nonsurvivors had higher median admission levels of IL-2, -8, -10, and granulocyte macrophage-colony stimulating factor; noninfected, nontrauma patients had higher IL-6, -8, and IL-10; and nonsurviving trauma patients had higher IL-4, -6, -8, and TNF-α. IL-4 was the most significant predictor of death and carried the highest relative risk of dying in trauma patients, and IL-8 in nontrauma, noninfected patients. In infected patients, no cytokine independently predicted death. Conclusions: Cytokine profiles of certain disease states may identify persons at risk of dying and allow for selective targeting of multiple cytokines to prevent organ dysfunction and death.",
author = "Tjasa Hranjec and Swenson, {Brian R.} and Dossett, {Lesly A.} and Rosemarie Metzger and Flohr, {Tanya R.} and Popovsky, {Kimberley A.} and Bonatti, {Hugo J.} and May, {Addison K.} and Sawyer, {Robert G.}",
note = "Funding Information: This work was supported by the National Institutes of Health grant: R01 AI49989-01 ( Clinicaltrials.gov identifier NCT00170560 ), and the University of Virginia General Clinical Research Center ( Clinicaltrials.gov identifier: NCT00170560 ). ",
doi = "10.1016/j.jamcollsurg.2009.12.042",
journal = "Journal of the American College of Surgeons",
T1 - Diagnosis-Dependent Relationships between Cytokine Levels and Survival in Patients Admitted for Surgical Critical Care
AU - Hranjec, Tjasa
AU - Swenson, Brian R.
AU - Dossett, Lesly A.
AU - Metzger, Rosemarie
AU - Flohr, Tanya R.
AU - Popovsky, Kimberley A.
AU - Bonatti, Hugo J.
AU - May, Addison K.
AU - Sawyer, Robert G.
N1 - Funding Information: This work was supported by the National Institutes of Health grant: R01 AI49989-01 ( Clinicaltrials.gov identifier NCT00170560 ), and the University of Virginia General Clinical Research Center ( Clinicaltrials.gov identifier: NCT00170560 ).
N2 - Background: Death after trauma, infection, or other critical illness has been attributed to unbalanced inflammation, in which dysregulation of cytokines leads to multiple organ dysfunction and death. We hypothesized that admission cytokine profiles associated with death would differ based on admitting diagnosis. Study Design: This 5-year study included patients admitted for trauma or surgical intensive care for more than 48 hours at 2 academic, tertiary care hospitals between October 2001 and May 2006. Cytokine analysis for interleukin (IL)-1, -2, -4, -6, -8, -10, -12, interferon-γ, and tumor necrosis factor (TNF)-α was performed using ELISA on specimens drawn within 72 hours of admission. Mann-Whitney U test was used to compare median admission cytokine levels between alive and deceased patients. Relative risks and odds of death associated with admission cytokines were generated using univariate analysis and multivariate logistic regression models, respectively. Results: There were 1,655 patients who had complete cytokine data: 290 infected, nontrauma; 343 noninfected, nontrauma; and 1,022 trauma. Among infected patients, nonsurvivors had higher median admission levels of IL-2, -8, -10, and granulocyte macrophage-colony stimulating factor; noninfected, nontrauma patients had higher IL-6, -8, and IL-10; and nonsurviving trauma patients had higher IL-4, -6, -8, and TNF-α. IL-4 was the most significant predictor of death and carried the highest relative risk of dying in trauma patients, and IL-8 in nontrauma, noninfected patients. In infected patients, no cytokine independently predicted death. Conclusions: Cytokine profiles of certain disease states may identify persons at risk of dying and allow for selective targeting of multiple cytokines to prevent organ dysfunction and death.
AB - Background: Death after trauma, infection, or other critical illness has been attributed to unbalanced inflammation, in which dysregulation of cytokines leads to multiple organ dysfunction and death. We hypothesized that admission cytokine profiles associated with death would differ based on admitting diagnosis. Study Design: This 5-year study included patients admitted for trauma or surgical intensive care for more than 48 hours at 2 academic, tertiary care hospitals between October 2001 and May 2006. Cytokine analysis for interleukin (IL)-1, -2, -4, -6, -8, -10, -12, interferon-γ, and tumor necrosis factor (TNF)-α was performed using ELISA on specimens drawn within 72 hours of admission. Mann-Whitney U test was used to compare median admission cytokine levels between alive and deceased patients. Relative risks and odds of death associated with admission cytokines were generated using univariate analysis and multivariate logistic regression models, respectively. Results: There were 1,655 patients who had complete cytokine data: 290 infected, nontrauma; 343 noninfected, nontrauma; and 1,022 trauma. Among infected patients, nonsurvivors had higher median admission levels of IL-2, -8, -10, and granulocyte macrophage-colony stimulating factor; noninfected, nontrauma patients had higher IL-6, -8, and IL-10; and nonsurviving trauma patients had higher IL-4, -6, -8, and TNF-α. IL-4 was the most significant predictor of death and carried the highest relative risk of dying in trauma patients, and IL-8 in nontrauma, noninfected patients. In infected patients, no cytokine independently predicted death. Conclusions: Cytokine profiles of certain disease states may identify persons at risk of dying and allow for selective targeting of multiple cytokines to prevent organ dysfunction and death.
U2 - 10.1016/j.jamcollsurg.2009.12.042
DO - 10.1016/j.jamcollsurg.2009.12.042
JO - Journal of the American College of Surgeons
JF - Journal of the American College of Surgeons


Labor Day, observed on the first Monday in September, celebrates the economic and social contributions of workers. We pause to remember and give thanks for those whose labor contributes to the quality of our common life. So many of the products we enjoy in this country are presented to us in final form in markets, stores, and showrooms that it is easy to take granted those who produced them. It is also easy to forget how our own work impacts the lives of others.
We can also apply the petition, "...not for self alone, but for the common good" to our Cathedral community. During this time of transition, everyone is called to generously work, pray, and give for the common good so that the mission of the Cathedral remains strong and vibrant. The ongoing life and work of any community of faith is not about who's in charge; it's about the generous spirit that makes us faithful and steadfast in the mission to which God is calling us.
The key is to hear the call of God to each of us to be the generous creatures we were designed to be and to all of us to work together energetically for the common good so that we can share God's bounty with others. When we do that, people are uplifted, transformed, and healed, and God is glorified.
St. Paul told the Corinthians, "You will be enriched in every way for your great generosity, which will produce thanksgiving to God through us; for the rendering of this ministry not only supplies the needs of the saints but also overflows with many thanksgivings to God" (2 Cor. 9:11, 12).
Jesus Christ, God Incarnate, is our greatest example of generosity. St. Paul referred to him as God's "indescribable gift." Jesus' method was to form a community and teach them by word and example. You and I are the descendants of that first community and now the message of Jesus and its meaning for our world today is entrusted to us.
Where are the places in the life of Saint Andrew's Cathedral in which you can work more energetically, pray more fervently, and give more generously for the spread of God's reign on earth? Please pray about that.
The New Testament knows no more meaningful act for affecting and witnessing to the relationship of Christians with one another and with Christ than eating together. Whoever removes eating from the list of profoundly religious acts will have great difficulty with the Gospel message.
If these are someone else's words, I failed to footnote them. I would like to give whoever wrote or spoke them credit. Wherever the words came from, I believe they are words of wisdom.
Is it any wonder that the heart of the Church's worship is a meal, that the presence of Christ is known in the breaking of bread, and that eating together at other times is such a central part of life in Christian community? Is it any wonder that we are spending five Sundays in a row exploring the layers of meaning in the sixth chapter of John?
I remember a story told by an Episcopal Priest concerning an experience early in his ministry. He came home from a very difficult vestry meeting in which he was denied pursuit of a vision about which he was passionate. He put his little daughter in her high chair, tied her bib around her neck, opened a jar of baby food, and proceeded to feed her. During the meal, his mind was still on his profound disappointment and he began to weep. His daughter, who could not yet speak, understood the language of her father's tears. She picked up her spoon, scooped up some baby food, and held it up to his lips. After he opened his mouth and tasted his daughter's offering, she picked up the napkin and wiped the tears from his eyes.
In the course of a meal, without words but with signs and actions, a little child brought compassion and helped the healing begin in her father. Jesus Christ does that with us each time we feast at his banquet table and whenever we break bread with one another in his Name. He did for the multitude on the hillside, for his first disciples in the Upper Room, for those two pilgrims at Emmaus, and he does it still in simple country chapels and magnificent cathedrals. He promises to gather us at a great banquet in heaven. We are his companions in this life and the life to come.
"Whoever eats of this bread will live forever; and the bread that I will give for the life of the world is my flesh" (John 6:51).
From time to time I remind myself and those given into my care that the Church doesn't have a mission. Rather, the mission has a Church! Christian communities are the delivery system for the mission of Christ.
• The Great Gift (John 3:16-17) ~ For God so loved the world that he gave his only Son, so that everyone who believes in him may not perish but may have eternal life. Indeed, God did not send the Son into the world to condemn the world, but in order that the world might be saved through him.
God's greatest gift of Love surpasses all I possess, given not for condemnation but for redemption. The Gift of the Son of God to reconcile us to God inspires, empowers, and motivates us in the work of reconciliation he has entrusted to us.
• The Great Commandment (Matthew 22:37-40) ~ You shall love the Lord your God with all your heart, and with all your soul, and with all your mind. This is the greatest and first commandment. And a second is like it: You shall love your neighbor as yourself. On these two commandments hang all the law and the prophets.
Jesus' summary of the law is the guide for our words and actions. Everything else depends on these two commandments, like a door depends on its hinges. Demonstration of love for God and love for our neighbors are the highest values of the Christian's life.
• The Great Commission (Matthew 28:18-20) ~ All authority in heaven and on earth has been given to me. Go therefore and make disciples of all nations, baptizing them in the name of the Father and of the Son and of the Holy Spirit, and teaching them to obey everything that I have commanded you. And remember, I am with you always, to the end of the age.
Jesus gave this commission to the Church. It is his intention for us to be united in his mission to be and to make disciples for the sake of the world.
How are we doing, Jesus?
If I asked the average Christian what is the greatest of God's commandments, I suspect most would respond, "Love the Lord your God with all your heart, mind, soul, and strength." And, if I asked what is the second greatest commandment, I'm pretty sure most would respond, "Love your neighbor as yourself." Jesus said that all the Law and the Prophets depend on these two commandments. Like a door depends on its hinges.
If I asked what is the most frequent commandment in the canon of Scripture, I might not find such a strong consensus. But there is one commandment that is found in most books of the Bible. Often, it is spoken by God. Many times, it is spoken by an angel. Sometimes it is spoken by Jesus.
Do you recognize that? Probably not. It's Hebrew and is pronounced Al tirah. Still don't recognize it? Okay, I'll bet you recognize the English translation FEAR NOT. This commandment appears 365 times in the canon of Scripture, once for every day of the year. In my review of the occasions in which the commandment is expressed, it seems that it is usually spoken in a situation in which anxiety is running very high. Now is one of those times.
Only this week, articles have been published describing the intentional use of anxiety to motivate people in the political process. The use of anxiety to motivate is not a new idea. It is customary in all unhealthy emotional systems, including religious communities. "Healing" those systems involves a decision on the part of each member to manage his/her own anxiety and to resist the efforts of those who use anxiety to motivate or influence others.
People are anxious about terrorists, gun rights, politicians, access to healthcare, the world economy, fluctuations in the market, job security, the Sunday morning schedule, and a host of other things that can be perceived as threatening to our lives or at least our way of life. Many are feeling that the situation around them has moved beyond their control. They feel powerless and maybe hopeless. When human beings reach such a state of anxiety, our primitive "fight or flight" program instinctively engages. When that happens, we lose some of our ability to reason. We might say or do all sorts of irrational and hurtful things as we express our anxiety and even take extreme, sometimes violent measures to regain control to protect ourselves, our loved ones, our values, and our possessions.
Our brains are designed to react in frightening situations. We have that in common with other living creatures, such as lizards. Without our survival instinct, our ancestors would not have made it. But human brains are also designed to help us reason and work with other humans in finding meaningful ways to respond to what threatens us.
your trust; and we turned against one another.
That's where the most frequent Biblical commandment comes in. God who designed and equipped us to care for each other and oversee the entire creation, tells us not to let our fears conquer our faith, our hope, our love, and our reason! "Al tirah! Don't be afraid!"
In spite of that, many people are anxious right now. Not everyone is having a good time. Not everyone feels secure. Small things are magnified so that they evoke reactions that are out of proportion to the facts. Even good news is frightening to some people.
The promise is that faith conquers fear. Our hope is that perfect love casts out fear.
Last Sunday, more than fifty voices filled the Choir at St. Andrew's Cathedral. They were participants in the Mississippi Conference for Church Music and Liturgy and it was the closing service. Among the beautiful anthems they sang was Sir C. Hubert H. Parry's setting of Psalm 122, "I Was Glad", which was composed for the coronation of England's King Edward VII in 1902.
That particular anthem always speaks to the deepest places of my soul. But long before I heard the music, I learned the opening verse. I was glad when they said unto me, Let us go into the house of the Lord.
Mr. Robert Frantis was my third grade Sunday School teacher and he asked us to memorize that verse. I will always be grateful to him for giving us that homework because that one verse formed in me a positive and passionate appreciation for the worship of God, which is a good thing to have in any case but especially if you are called to ordained ministry.
Glad is an adjective. Its origins are as follows: Old English glæd "bright, shining, gleaming; joyous; pleasant, gracious" (also as a noun, "joy, gladness"), from Proto-Germanic gladaz (source also of Old Norse glaðr "smooth, bright, glad," Danish glad "glad, joyful," Old Saxon gladmod, in which the element means "glad," Old Frisian gled "smooth," Dutch glad "slippery," German glatt "smooth"), from Proto-Indo-European root ghel- "to shine." Apparently the notion is of being radiant with joy; the modern sense "feeling pleasure or satisfaction" is much weakened.
My takeaway from all of that is that is the perfect description of how I feel about the opportunity to worship God – "I was radiant with joy when they said unto me, let us go into the house of the Lord." Gathering with God's people in a sacred space set apart for divine worship truly makes my heart glad.
Corporate worship, which is essential to the life of every Christian and the life of every Christian community, is something I always look forward to. Why is that? Perhaps it is because it is one time in my week or my day that is guaranteed not to be about me. It is about God and the other people in my life. It is an opportunity to get myself off my hands, set aside my own pursuits, and to be vulnerable before my Creator.
Hear what our Lord Jesus Christ saith: Thou shalt love the Lord thy God with all thy heart, and with all thy soul, and with all thy mind. This is the first and great commandment. And the second is like unto it: Thou shalt love thy neighbor as thyself. On these two commandments hang all the Law and the Prophets.
That summary reminds us why we are gathered; it's all about God and the neighbors. In worship, my thoughts, concerns, activities, and priorities are regularly restored to the default settings given by Jesus Christ himself and I am reminded once again that it is not all about me. That makes my heart glad. That causes me to be radiant with joy.
Here's a recording of Parry's "I Was Glad." It says it all.


What Citrus Juicer Is The Best For Your Demands?
Utilizing these juicers permits you making the most from your oranges, lemons, limes, tangerines, and grapefruits. To get fresh juice in the early morning Citrus juicers are developed simply to deal with these particular kinds of fruits. Other juices may not handle citrus fruit also due to the fact that they consist of various elements like seeds, thicker skins and division.
You should know that juicing citrus will certainly call for a various method. As an example, did you know that because of the chemicals in them eating the skin of grapefruits, tangerines, as well as oranges will harm your gastrointestinal system. Yet on the various other hand it is great to eat the skin of lime as well as lemons. By including fresh juice into your day-to-day live you will gain more of the vitamin C, potassium, calcium, thiamine as well as niacin.
To obtain as much of the nutrients as feasible you need to constantly try and consume the juice when it is a fresh as feasible. Citrus juicers could also help reduce your cholesterol by provide you with a soluble fiber called pectin. When you are buying the sort of fruit juicer that will manage your oranges you will notice 2 types of citrus juicers that will extract your beverage. One supplies complete citrus juice as well as the other one develops citrus water To discover more details, Click This Link..
When using all the parts of the fruit like the sector, and also outer skin you get exactly what is described as overall citrus juice. This gives you a sudsy uniformity and also might taste a little much less sweet yet you get extra nutrients. The kinds of juicers to produce this outcome are more advanced that a citrus water juicer. On the other hand citrus water is developed when only the fruit's fluid is squeezed or pressed out. There will be little pulp and it will show up a little watery.
The industry has generated several selections of juicers for these types of fruits. You have the Guidebook citrus juicers made from plastic, glass, or metal. To utilize this kind you cut the fruit in half as well as squeeze it versus an apparatus that filters the juice right into a cup. This can be an untidy method to get juice. After that you have the electrical reamer that produces more juice compared to the hand-operated way of squeezing the juice out of the fruit.
The easiest and most reliable method to produce citrus water is using a press. To earn total citrus juice, most of the juicers have upgradeable choices so explore that so you could create the highest level of nutrients from your juice.
Prior to buying a citrus juicer the other things you must bear in mind are: the electric motor speed, the wattage, constant juicing abilities, pulp ejection, along with transparent covers. For your final decision look for juicers with a good cost and good evaluations.


Brother William Tany, prior of the hospital of St John of Jerusalem in Ire., C. of Ire., has pleaded that lately, by order of the Lt and Thomas Mortimer, deputy of the Lt, he retained defensible men in the company of the deputy at […]lagh, Kilkenny, and Cashel on account of the war waged by the Irish in those parts […] as an aid to resist the malice of the Irish […] and the issues profits of the said […]; and he incurred great expenses on that expedition to an excessive sum and the depreciation of his estate and his impoverishment. He seeks reward. Being inclined to his plea, the K. grants the prior £20 of his gift in recompense for his expenses. ORDER to pay him that sum.
TNA (PRO), E 101/246/3, §220.


Beachwood Bbq & Brewing will is adding Amalgamator IPA to it's series of bottled IPAs.
Amalgamator IPA is a West Coast India Pale Ale that's bursting with unique aromas and flavors. This bold IPA is kettle hopped with Amarillo, Warrior, Columbus, and Mosaic, a new American variety. The dry hop is a massive charge of Mosaic that lays down an amalgam of passion fruit, blueberry, dank resin, and citrus aromas.
Amalgamator IPA bottles will be released at both Beachwood locations on February 25th, 2014 at 5pm.
Celebrate the addition of this aromatic IPA with food specials and festivities at our Long Beach location.


text:
Prime Minister's Schemes प्रधानमंत्री योजना
All about Pradhan Mantri yojana and other government schemes in India.
Schemes List
Awas Yojana
FAQ on PM Awas Yojana
Helpline-Toll Free Number
Credit Linked Subsidy Scheme
List of PLI
प्रधानमंत्री आवास योजना
ग्रामीण आवास योजना
Gramin Awas Yojana
Other PM Yojana
PM Kisan
PMFBY
PMJDY
Gold Monetization Scheme
Req. Documents for Home Loan
PMAY Success Story
State Housing Scheme
Prime Minister Shri Narendra Modi Addressed United Nations General Assembly
Admin latest news, pm No comments
Prime Minister addresses the United National General Assembly
Prime Minister Shri Narendra Modi addressed the 74th session of the United Nations General Assembly (UNGA) in New York today.
Evoking Mahatma Gandhi, Prime Minister said that Gandhiji's message of truth and non-violence is relevant even today for peace, progress and development of the world.
Prime Minister highlighted the huge transformation brought about by the pro–people initiatives of the Government like Swachh Bharat, Ayushman Bharat, Jan Dhan Yojana and Digital identification (Aadhar). He added that when India pursues such initiatives, it instills hope in the entire world.
Prime Minister mentioned about India's commitment towards eliminating single use plastic. He spoke about the government's commitment to provide water to every household, a house for every family and elimination of tuberculosis in the coming five years.
Emphasizing on Indian culture, Prime Minister said public welfare is part of our cultural ethos. He said that public welfare through public participation is the mantra of his government.
In addition to fulfilling the dreams of 130 crore Indians, the efforts of the government will also be beneficial to the entire world. "We are working not just for the welfare of our people, but for the welfare of the entire world. That is why our motto is Sabka Saath, Sabka Vikas, Sabka Vishwas', PM added.
Terming terrorism as the biggest challenge for the world, Prime Minister urged all the nations to unite against terrorism for the sake of humanity. "India is a country that has given the world, not war, but Buddha's message of peace,'' the PM said. He also mentioned about India's contribution to the United Nation peacekeeping Mission
Prime Minister urged the international community to give a new direction to multilateralism. He said as the world is going through a new era, the countries do not have the option to confine themselves within their boundaries. "A divided world is in no one's interest. We must give a thrust to multilateralism and reforming the United Nations," the PM said.
Prime Minister invoked the quotes of Tamil philosopher Kaniyan Pungundranar and Swami Vivekananda to seek collective action to address various global challenges. He said that 'Harmony and Peace' is the message of the world's largest democracy to the rest of the world.
Speaking about global warming, Prime Minister said that even though India's contribution towards global warming in terms of per-capita emissions is very low, India is at the forefront of the response against it. In this context, he elaborated on the steps taken by his government to fight climate change, including the 450 GW of renewable energy target and the formation of International Solar Alliance.
(Release ID: 1586535)
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प्रधानमंत्री योजना
प्रधानमंत्री आवास योजना Prime Minister Awas Yojana (PMAY)
सबके लिए आवास (शहरी) मिशन Housing For All (Urban) Mission
माननीय प्रधानमंत्री ने राष्ट्र की स्वतंत्रता के 75 वर्ष पूर्ण हो जाने पर वर्ष 2022 तक सभी के लिए आवास की परिकल्पना की है। इस उद्येश्य की प्राप्ति के लिए केन्द्र सरकार ने एंक व्यापक मिशन "2022 तक सबके लिए आवास" शुरू किया है। 25 जून 2015 को प्रधानमंत्री श्री नरेन्द्र मोदी ने इस बहुप्रतीक्षित योजना को प्रधानमंत्री आवास योजना के नाम से प्रारम्भ किया है।
Hon'ble Prime Minister envisioned housing for All by 2022 when the Nation completes 75 years of its Independence. In order to achieve this objective, Central Government has launched a comprehensive mission "Housing for All by 2022". This much awaited scheme has been launched by the Prime Minister of India, Sh. Narendra Modi on 25th June, 2015 as Pradhan Mantri Awas Yojana.
PM Awas Yojana प्रधानमंत्री आवास योजना
प्रधानमंत्री आवास योजना सबके लिए आवास (शहरी) मिशन Click here to know the scheme details in English Click Here to know about onli...
सरकारी योजनाओं / प्रधानमंत्री योजनाओं की सूची : List of Central Government of Schemes
List of Central Government Schemes of Government of India केन्‍द्र सरकार के सभी सरकारी योजनाओं की सूची Here is the complete list o...
Pradhan Mantri Awas Yojana - Latest Progress Report
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Beneficiaries under PMAY-G
Beneficiaries under PMAY-G प्रधानमंत्री आवास योजना के लिए योग्‍य लाभार्थी कौन है? जानिए पूरी जानकारी बस एक क्लिक पर । (a) whether the...
Gramin Awas Yojana "Gramin" under PM Awas Yojana
2022 तक सबके लिए आवास हेतु प्रधानमंत्री आवास योजना की ग्रामीण आवास योजना- 'ग्रामीण' का क्रियान्वयन DDA Aawas Yojana 2017 के बा...
Prime Minister Awas Yojana (PMAY) Housing For All (Urban) Mission हिन्दी में जानने के लिए यहां क्लिक करें हिन्दी भाषा में FAQ पढ़न...
List of Selected Cities under PMAY - HFA (Urban)
List of Cities selected under Prime Minister Awas Yojana - Housing For All (Urban) Apply Online City Name Urban Population as per ...
PMAY : Physical & Financial Progress
PM Awas Yojana : Physical & Financial Progress as on 18th May, 2016 Total No. of Cities considered for funding : 671 Total Proje...
Model Application Form - PM Awas Yojana
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Rashtriya Swasthya Bima Yojana : Unstarred Question in Loksabha
Rashtriya Swasthya Bima Yojana (a) whether the Government proposes to expand the personal health insurance and community health insuranc...
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Raipur : State Congress President Bhupesh Baghel was on Sunday named the new Chief Minister of Chhattisgarh and he vowed in no time to cancel within 10 days bank loans taken by farmers -- a campaign promise that led to the BJP's rout in Assembly elections.
Shortly after the 58-year-old Baghel was elected the Congress Legislature Party leader by party MLAs, the Congress leader announced that he would take oath as the third Chief Minister of Chhattisgarh on Monday at 4.30 p.m. at the Science College Ground here.
Mallikarjun Kharge, the Congress observer for Chhattisgarh, told the media that Baghel was elected unanimously by the MLAs but only he would take oath on Monday. The names of Ministers would be declared later "after detailed discussions with all stake-holders".
"I am committed to waiving farmers' bank loans within 10 days," said Baghel, a post-graduate from Pandit Ravishankar Shukla University here and a father of four.
He added that the Congress government will unravel the conspiracy that led to the killing by Maoists of top Congress leaders in the Jheeram Valley in Bastar in May 2013 including the then state Congress chief Nandkumar Patel, the veteran V.C. Shukla and Mahendra Karma.
In his first tweet as Chief Minister elect, Baghel expressed his gratitude towards Congress President Rahul Gandhi and said Gandhi had given him the responsibility of building "a new Chhattisgarh".
"I can assure the great people of Chhattisgarh that the new Congress government would live up to their expectations and wishes."
The Congress said on Twitter: "We wish him the best as he forms a government of equality, transparency and integrity starting off with farm loan waiver for farmers as we promised."
Baghel is a powerful leader of the OBC community which makes up 52 per cent of the state's 2.55 crore population.
The five-time MLA was elected from Patan in Durg district. He was Revenue Minister in Ajit Jogi's first government in Chhattisgarh that was voted out in 2003.
Baghel was also in the centre-stage of the ousted BJP government's attacks and was recently jailed for some days in Raipur after he was charge-sheeted by the CBI for his alleged role in the circulation of a sleaze CD against a powerful BJP Minister in Chhattisgarh.
He launched his political career in early 1980s from Durg district under the guidance of the late Chandulal Chandrakar. He joined the Youth Congress in 1985 and was elected to the undivided Madhya Pradesh Assembly for the first time in 1993.
Hailing from a farmer's family, Baghel is credited with leading the party from the front in the fight against the Bharatiya Janata Party (BJP) and scripting the crushing defeat of the 15-year-old regime of Raman Singh. The Congress won 68 of 90 seats.
And although there were other contenders too for the Chief Minister's post, Baghel was far ahead of them unlike in Madhya Pradesh and Rajasthan where there was intense tussle as to who would get to helm the states.
Ashok Gehlot is Rajasthan's Chief Minister designate and Madhya Pradesh has Kamal Nath in the top post. They too will take oath on Monday.
With Sunday's development, all three states in the Hindi heartland where the BJP lost power to the Congress now have Chief Ministers.


If you were born before 1992, you may remember a TV commercial with talking penguins. This classic TV ad promoted the soothing effects of Nice Cough Drops for cough and minor sore throat. Nice Cough Drops has not been sold in the U.S. for more than 10 years, but they are now available at Price Chopper and Market 32 Pharmacies. Nice cough drops are sugar-free and diabetic safe. Check the diabetic section at participating locations.


A$AP Rocky said Wiz Khalifa and other Hip Hop artists are smoking too much.
A$AP Rocky followed the aforementioned words with a Wiz Khalifa story. The Blacc Hollywood rapper supposedly offered the New York artist a dab (potent, smokeable marijuana oil) and Rocky folded under the peer pressure. Rocky tried to hide his elevation with a poker face, but says he eventually hit "that one part" and nearly fell over.
Rocky dropped his At.Long.Last.A$AP album last week.


Condyne and Polar Design Build completed a 90,000 square-foot tenant fit-up that includes new office and warehouse space for 1A Auto in Littleton, MA. 1A Auto is a second generation, family owned and operated national auto parts retailer. The building includes all new offices, restrooms, a break room, an IT room, and cube farms. The warehouse is racked with conveyer belts throughout, and high-bay LED motion sensor lights were installed. It is capable of handling future mezzanines for storage and parts, and boasts epoxy flooring. The electrical and sprinkler systems also underwent a complete upgrade. Condyne also acts as the property managers for the building 1A Auto is located off Route 495 near recreation facilities, restaurants and automobile dealerships.


text:
Photo added by George Seitz
Pvt Daniel French Dulany III
1864 (aged 21–22)
Falls Church Episcopal Church Cemetery
Falls Church, Falls Church City, Virginia, USA
French served with Company A of the 43rd Battalion of Virginia Cavalry - Mosby's. On 27 September 1863, French and a few other Rangers from Company A rode with Mosby to Alexandria. The intent was to capture the Governor appointed by Lincoln. The Governor's mansion was empty. The plan was altered to capture the Governor's military aide, Colonel Daniel French Dulany, who was staying at the nearby Rose Hill Manor. Colonel Dulany was young French's father. The raiders found Colonel Dulany in bed. French greeted his father, "How do Pa - I'm very glad to see you." His surprised father replied, "Well sir, I'm damn sorry to see you." As they were leaving, Colonel Dulany sarcastically remarked to his son that there was an old pair of shoes in the house and that French should take them, seeing that the Confederacy was in need of such things. French lifted his leg to display a fine new Cavalry boot, just captured from a Union sutler, and asked the old man what he thought of that. Mosby and French headed back with their prize, French's own father. Colonel Dulany was sent to Libby Prison in Richmond. He was soon exchanged and sent back to Fairfax. He survived the war. French Dulany was not so lucky. He was mortally wounded by members of the Second Massachusetts Cavalry almost one year later in a raid at Herndon. Eyewitnesses state that French continued on some distance after being shot. A doctor was summoned, but the wound was declared fatal. French told the doctor that if he saw his father, give him his warmest regards, and tell him that he has given up.
See more Dulany memorials in:
1850 United States Federal Census
Created by: George Seitz
Added: 11 Dec 2014
Find a Grave, database and images (https://www.findagrave.com/memorial/139885585/daniel-french-dulany: accessed ), memorial page for Pvt Daniel French Dulany III (1842–1864), Find a Grave Memorial ID 139885585, citing Falls Church Episcopal Church Cemetery, Falls Church, Falls Church City, Virginia, USA; Maintained by George Seitz (contributor 40539541).
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