What Remains of Edith Finch is, conceptually, probably the most interesting game I've seen in the last year. I've still played only about 20 minutes of it.
But those are an intriguing 20 minutes. Edith Finch tells a story of the titular Edith, the last survivor of the Finches, investigating her family's boarded-up home. As you control Edith and try to solve the mystery of what has happened to her apparently cursed family, they find their way into the various sealed bedrooms of family members who've died, going back all the way to 1900.
While Edith's experience of exploring the house is the frame for the game, as Creative Director Ian Dallas puts it, What Remains of Edith Finch is actually a series of smaller games, like interactive short stories. Each first-person vignette has its own set of mechanics, but they all share a particular link — they're all about Finch family members at the moment of each of their deaths.
It sounds dark, but What Remains of Edith Finch isn't going for horror or shock with these moments. Instead, it's more of a surreal experience. There's positivity in dying, as well as tragedy. It's … weird.
Edith Finch's frame story plays a lot like the narrative exploration game Gone Home — players explore the home of various other, absent characters, learning about who they were and what they went through based on the remnants of their lives. But that's only part of the experience. Edith Finch's playable vignettes work like interactive looks into those character's psyches, offering a different perspective on who they were and what they went through when they died.
Those vignette portions are more like some of the hidden short story experiences in another narrative exploration game, The Vanishing of Ethan Carter, or you could liken it to some of the shifting of characters and mechanics in GameCube horror classic Eternal Darkness. Unlike that game, though, Edith Finch's vignette bits are a little more thoughtful and weird, and definitely not nearly as frightening or action-driven.
The moments in what developer Giant Sparrow has shown of Edith Finch so far are certainly memorable. In one, you control a space-obsessed kid, Calvin Finch, growing up in the 1960s as he swings on a back yard swing set. The idea is to push ever higher, until finally, Calvin achieves the flight he obsesses over — rocketing off his swing, past a fence, and over a cliff toward the waiting ocean. We don't see Calvin fall; instead, controlling him, we fly out over the waves. From what we've seen in his room, we know that he finally achieved what he was longing for, even though it cost him his life.
Another scene, the story of Molly Finch, finds the young girl stuck in her 1950s bedroom, punished and sent to bed without dinner. As Molly struggles with her hunger, she imagines herself as a cat stalking a bird in the branches of trees outside her window — and you become the cat. Then the cat becomes an owl, and you soar above a forest, searching for mice to eat. Next, you become a shark, ravaging schools of fish, and finally morph into some strange, tentacle-laden sea creature that lays waste to a ship full of human passengers. The vignette ends with the monster making its way through an undersea pipe to emerge from the plumbing in a bedroom — Molly's bedroom.
Each short story is different, but each illuminates a little bit more of the Finch family, their lives and their deaths. Dallas said that wasn't always the case, though. The original idea for Edith Finch was about being freaked out by the natural world.
When Giant Sparrow started working on it, the game that became Edith Finch was about scuba diving — although it still looked to invoke the current game's combination of creeping dread and a surreal sort of beauty.
From there, things shifted, Dallas said. There was one conception of Edith Finch in which each short story would be created by a different game developer, creating a kind of anthology, that didn't work out. Instead, Giant Sparrow landed on the unifying idea of telling the stories of a family, and that started to draw the short story experiences together into a more unified whole.
Though it's a singular game, linked together by Edith's exploration of the house, Dallas still describes What Remains of Edith Finch as a kind of anthology game, likening it to The Twilight Zone. Each of the short stories pretty much started as a single interactive idea, developed as a Unity prototype, he said. From there, as each idea was refined, Giant Sparrow wrote stories around them. Edith Finch was never a single story built in parts, he said. Instead, it started in the stage of interactivity, with the developers creating interesting moments, and then finding ways to create a whole out of the parts they'd built.
That method of constructing the game meant that pieces have come, gone, and changed dramatically, Dallas said. Ideas have sprung from many different places, like concepts for individual characters and the overall story itself as it was coming together, but ultimately it was the ones that were easy and fun to implement through interactivity that were the best.
Finding the start of each story, and creating the connective tissue of Edith's tale, was one thing. Bringing the stories together toward a singular goal was something else.
However dark Edith Finch is as it explores death, it's not all despairing. Molly's story is strange and fantastical, and Calvin's is even uplifting, a choice and an affirmation even if it's a tragic one.
We'll see What Remains of Edith Finch released in early 2017 on PlayStation 4. At that point, Dallas said, he hopes players will play and replay through the various moments of characters' deaths, and that Giant Sparrow's game will manage to be affecting without being depressing — to walk a line that brings up a variety of emotions.


text:
Q: Importing SCSS Without Comments Can I import a SCSS file, into another SCSS, without including the multiline (/* */) comments?
I have a site.scss file that is importing a _baseline.scss stylesheet (which is a custom CSS reset style sheet). In both files I have a large block comment:
/**
  *
  * DO NOT MODIFY CSS FILE: This file is part of a SCSS/CSS pair. CSS content is
  * automatically generated by the Sass compiler, only the '.scss' file is to be
  * modified. Any changes made directly to the CSS will be lost.
  *
  */

The goal being to prevent developers from editing the CSS file in the code repository. I want this in each file, since each file can/will be touched independently.
However, when I save my site.scss file I get this message twice!
Is there a way I can flag the comments in _baseline.scss to not be imported when I bring them into site.scss?

A: You can possibly create _css-notice.scss which you include at the top of site.scss and there you place your notice:
/**
  *
  * DO NOT MODIFY CSS FILE: This file is part of a SCSS/CSS pair. CSS content is
  * automatically generated by the Sass compiler, only the '.scss' file is to be
  * modified. Any changes made directly to the CSS will be lost.
  *
  */

Remove the notice from all of your other files.
Additionally  you could make the site.scss an import only file without specifying anything else like it is in bootstrap for instance:
https://github.com/twbs/bootstrap-sass/blob/master/assets/stylesheets/_bootstrap.scss

redpajama_set_name: RedPajamaStackExchange


SOP- Responsibility of Production Dept.
To define the responsibilities of Production Department.
This procedure is applicable to all personnel working in Production Department.
To ensure Good Manufacturing Practices.
To ensure data integrity throughout the whole process.
To ensure proper sanitation, cleaning and housekeeping in chemical area & powder processing area.
Making sure that production facilities are clean and when appropriate disinfected.
To follow entry-exit procedure for powder processing area to avoid contamination.
Preparation of SOPs, Protocols & Reports for validation, Batch records, equipment cleaning records.
Making sure that validation protocols and reports are reviewed and approved.
Preparing, reviewing, approving and distributing the instructions for the production of drug substances &/or drug products according to written procedures.
Producing drug substances &/or drug products and, when appropriate, according to preapproved instructions.
Making sure that the necessary calibrations are performed and records kept.
Making sure that preventive maintenance of all equipments has been performed as per their schedule in co-ordination with engineering department.
To ensure that all the status & tags are available at their respective positions.
To ensure the availability of the all utilities, raw materials, packaging materials, solvents before proceeding for the batch.
Making sure that the premises and equipment are maintained and records kept.
Evaluating proposed changes in product, process or equipment.
Making sure that new and, when appropriate, modified facilities and equipment are qualified.
In case of any non-conformance, immediately reporting to head / designee for the necessary actions.
productionmanagerresponsibilitiesSOP- Responsibility of Production Dept.
Previous Previous post: SOP- Responsibility of Microbiology Dept.


i know every mom knows the quote "the days are long, but the years are short." that is how our days have been going! enough hours in a day to get chores done, play, go places, but the weeks pass so quickly! and they don't seem like they are, but the calendar says differently.
so backing it up the the first weekend in february when we got snow! AND kami & jonathan (now engaged!) came to visit. but the biggest highlight of all was on Thursday, February 6th, 2014 Bentley explained the gospel to caroline, kami, & jonathan & told how he believed that Jesus died on the cross for his sins, and we all have sins, but if we believe that Jesus died for us, we can go to heaven. he said "i believe this! do you guys?" what an awesome moment....that i wasn't there for, but glad to have my sisters be able to tell me about!
baby boots from aunt kami!
valentines weekend. a surprise note by my bed, a growing 31 week belly, valentine treats for the basketball girls, a lunch date with my husband, a home basketball game with my sisters (& starbucks), and the surprise of that weekend was after the game, each of the basketball girls came over to me & gave me a rose. AND shawn had flowers for my sisters & a little gift for bentley. it was such a surprise & i felt like i was in a movie.
the rest of the month... more basketball (this is our last weekend of the season), grandma & grandpa came to visit, a sunny day followed by a snowy day, "play dates" between me & bentley. he is in a growing stage! eating a lot, having TONS of energy that is accompanied by TONS of questions.
hot cocoa= almond milk, honey, & cocoa powder!
next month is the last full month before my due date. WHAT?! i know, it is sneaking up on me as much as it is you. not to say i don't have tons of reminders (wild baby, or if not being crazy, then hiccups, giant belly that makes me debate on picking up things i drop, feeling slower & a little more tired sooner than i did with B) I know it will all happen so quickly. But i will aim to pop back in & update on our day to day life in March, so i can remember to appreciate EACH day for what it is.
i love the new header! the valentine's nails are so pink/red and fabulous. were you tanning outside?? every time i see a burke sisters picture, it always makes me wish i had sisters. not to get cheesy and sappy, but i do have pretty awesome sisters-in-law that make up for it. and i'm really glad that i grew up with brothers. so i'm okay!!
Also - yes about feeling tired. Remember the days when you were pregnant with Bentley when you could rest after work or on the weekends? Not any more! B is so cute. I love when you blog!!


text:
package org.springframework.security.web.server.authentication;

import org.springframework.security.core.Authentication;
import org.springframework.security.web.server.DefaultServerRedirectStrategy;
import org.springframework.security.web.server.ServerRedirectStrategy;
import org.springframework.security.web.server.WebFilterExchange;
import org.springframework.security.web.server.savedrequest.ServerRequestCache;
import org.springframework.security.web.server.savedrequest.WebSessionServerRequestCache;
import org.springframework.util.Assert;
import org.springframework.web.server.ServerWebExchange;
import reactor.core.publisher.Mono;

import java.net.URI;

/**
 * @author Rob Winch
 * @since 5.0
 */
public class RedirectServerAuthenticationSuccessHandler
	implements ServerAuthenticationSuccessHandler {
	private URI location = URI.create("/");

	private ServerRedirectStrategy redirectStrategy = new DefaultServerRedirectStrategy();

	private ServerRequestCache requestCache = new WebSessionServerRequestCache();

	public RedirectServerAuthenticationSuccessHandler() {}

	public RedirectServerAuthenticationSuccessHandler(String location) {
		this.location = URI.create(location);
	}

	public void setRequestCache(ServerRequestCache requestCache) {
		Assert.notNull(requestCache, "requestCache cannot be null");
		this.requestCache = requestCache;
	}

	@Override
	public Mono<Void> onAuthenticationSuccess(WebFilterExchange webFilterExchange,
		Authentication authentication) {
		ServerWebExchange exchange = webFilterExchange.getExchange();
		return this.requestCache.getRedirectUri(exchange)
			.defaultIfEmpty(this.location)
			.flatMap(location -> this.redirectStrategy.sendRedirect(exchange, location));
	}

	/**
	 * Where the user is redirected to upon authentication success
	 * @param location the location to redirect to. The default is "/"
	 */
	public void setLocation(URI location) {
		Assert.notNull(location, "location cannot be null");
		this.location = location;
	}

	/**
	 * The RedirectStrategy to use.
	 * @param redirectStrategy the strategy to use. Default is DefaultRedirectStrategy.
	 */
	public void setRedirectStrategy(ServerRedirectStrategy redirectStrategy) {
		Assert.notNull(redirectStrategy, "redirectStrategy cannot be null");
		this.redirectStrategy = redirectStrategy;
	}
}

redpajama_set_name: RedPajamaGithub


Sometimes all a person needs to appreciate a full and independent life is a little assistance with routine daily activities. Other times, substantial personal care is required. Our goal at Emerald Gardens is to help our residents achieve maximum independence, while supplying excellent social, physical and emotional support.
Emerald Gardens works to provide a sense of community with an emphasis on maximizing resident independence, self-worth and dignity. We provide personal care and support services [link to personal care services] that are tailored to meet individual needs.


1. Who has to sign a release?
Any person who wants to climb, belay or take a class at The DE Rock Gym, must sign a DE Rock Gym release agreement. If the participant is under 18 then their parent or court-appointed legal guardian must sign the release agreement on their behalf.
2. Who may sign a release?
Participants over 18 years of age or a parent or court-appointed legal guardian for a minor.
NOT: Host families for exchange students, Aunts/Uncles, Grandfathers/Grandmothers, Etc.
3. What is the Difference between trial climbs and a day pass?
Trial climbs is a set of 3 roped climbs that includes a D.R.G. staff member for belaying and a harness. Climbing shoes are available for $5, but not required.	Please see the pricing page for further details.
A Day Pass is entry to the gym all day. It does not include a D.R.G. Staff member to belay or any other equipment. You may leave and return to the gym within the same day under the day pass. This applies to your equipment rentals as well. Please see the pricing page for further details.
4. Do I have to take the Intro to Climbing Class if I am new to climbing?
No. Anyone may climb in The D.R.G. However, to belay or tie-in the participant must pass The D.R.G. Tie-in and Belay Test. It is recommended that beginners take the Intro Class to learn the basic belaying skills. Must be 14 years old to take the Intro Class. Classes can be scheduled at alternate times by appointment. Please call the gym to schedule.
Belaying is the act of controlling a rope to protect a climber. The person belaying takes up slack in the rope when someone is climbing, arrests the climber if they fall and lowers the climber to the ground when they are finished climbing.
If you know how to belay you can meet other climbers in the gym and trade belays with them. If you do not know how to belay you may learn through the Intro to Climbing class if you are over 14. If you are under 14 a parent may take the Intro to Climbing Class to learn to belay for you.
6. What is the difference between roped climbing and bouldering?
Bouldering is short non-roped climbing. You climb to a limited height and then either climb down or drop down to landing pads. Though bouldering is shorter climbing it begins at a more difficult level then roped climbing.
Roped climbing is where you climb to a tall height where the use of ropes, harnesses and other equipment is required. In order to rope climb you need to either know how to belay or have someone to belay for you.
There is no age limit for someone to climb, but is usually around 5 or 6 years old that children are willing and able to climb. We do have children's harnesses. However, there is an age limit on belaying. You must be 14 years old to belay or to take the Intro to Climbing Class.
We except payments in the form of cash, Visa, MasterCard, and Discover.
9. Can I have a party at the gym?
Yes. Please see the Party page.


The graphic above describes the different levels of development we can work on for our embedded GNU Radio systems.
On the far left are where the real embedded experts work to develop the Board Support Package (BSP) that allows us to boot and run on various different embedded boards. Most of us will never touch this space as GNU Radio developers.
The next level is the basic OpenEmbedded (OE) level of development. This is the base Operating System (OS) and GNU Radio libraries. On this level, we provide the OS will all of the tools and libraries for a working GNU Radio system. The GNU Radio development team and the Embedded Working group takes care of this level. General embedded developers are unlikely to need to work on this level of development, though feedback to the Embedded Working Group is useful to keep the system up-to-date with the proper support infrastructure.
Developers then work on the OE software development kit (SDR) provided by the GNU Radio development team. Developers use the SDK to build their own GNU Radio applications and any Out-of-Tree projects for specific tasks. Results at this level are applications and/or libraries for use on other, similar embedded systems and ready for deployment.
Deployment is the final stage where development is completed and we have the OS, libraries, and apps built for our specific deployment needs.
This page is dedicated to understanding the development cycle and how to use the tools to accomplish your embedded task with GNU Radio. We expect most developers to care about using the SDKs for their embedded systems and not the details for how to create your own OE distribution or SDK. For those of you who require more detailed knowledge or insist on using OE yourselves, we provide information about that as well.
The rootfs: this is the file system of the embedded device, often placed on the root partition of an SD Card or micro SD Card.
The boot system: very device-specific to load the initial kernel and boot into the rootfs. Generally using u-boot.
The SDK: the software development kit provides the necessary libraries and executables to cross-compile projects targeted to the embedded device but built using a more powerful, capable desktop computer.
We have heard of success stories with other embedded devices such as the RaspberryPi. We have not direct support for these, however, but there are members of the GNU Radio community who can help. See the MailingLists to look for help.
Interact with the device over the serial debug port.
Access the device's root file system from the host over sshfs.
cmake [other options] -DCMAKE_C_FLAGS="-march=armv7-a -mthumb-interwork -mfloat-abi=hard -mfpu=neon -mtune=cortex-a9" -DCMAKE_ASM_FLAGS="-march=armv7-a -mthumb-interwork -mfloat-abi=hard -mfpu=neon"
rootfs: The root file system image as a tar.gz file.
SDK: the SDK as a self-installing shell script.
Boot files: files used to boot the machine.
NOTE: We are still working out a few final wrinkles, so these files are likely to evolve over the next few weeks/months. All uploaded images and SDKs are tested and will work for normal operations for the targeted architecture. Just be aware that there may be a few missing or buggy features.
The images are all built with both shared and static libraries.
Due to an issue with Orc, use of Orc in VOLK is disabled on ARM hard-float.
If the SDK image is geared towards a specific device, like the Zedboard, then then we provide the boot files such as the u-boot image itself, the kernel image, device-tree file, and other possible settings.
Neither GNU Radio nor the UHD drivers are built against ORC and so may suffer speed issues due reduced use of SIMD vectorization.
Start by using Philip Balister's OE Manifest for GNU Radio. Follow the instructions in the readme in that repo. You may wish to tweak a few parameters, which we can now do completely in the local.conf files.
When following the manifest instructions, before running bitbake, edit conf/local.conf. The main changes we use to build the different SDKs involve adding support for static libraries and toggle GUI support on/off. The following example is what we used to build the non-GUI version of the SDK that also includes static libraries for all of our programs.
#DISTRO_FEATURES_append = " opengl x11"
SDKIMAGE_FEATURES = "dev-pkgs dbg-pkgs staticdev-pkgs"
PACKAGECONFIG_append_pn-volk = " staticlibs "
PACKAGECONFIG_append_pn-uhd = " staticlibs "
PACKAGECONFIG_pn-gnuradio = " uhd logging ctrlport zeromq staticlibs "
PACKAGECONFIG_pn-gr-osmosdr = "uhd rtl-sdr hackrf rfspace "
The DISTRO_FEATURES can be uncommented to add back in GUI support. When enabling GUI support, we can also add "grc" and "qtgui" to the PACKAGECONFIG_pn-gnuradio line. This example also removed "bladerf" from the list of supported gr-osmosdr devices because it does not currently build a static library. If static libraries are of no concern, adding "bladerf" to this line re-enables that device.
All problems and bugs should be reported directly to the meta-sdr github repo.
This page was last modified on 21 March 2017, at 01:08.


text:
14 January 2021 10 January 2021 by WomenAgainstRape
We are relieved the court ruled not to extradite Julian Assange to the US. His immediate release from Belmarsh, classified as torture by the UN Special Rapporteur, especially under coronavirus, must follow. The refusal of bail must be reversed immediately.
As an anti-rape organisation, we resent the original use of alleged sex offences to facilitate Assange's extradition to the US via Sweden. Knowing the evidence, that case was never viable, but it initiated and fuelled a witch-hunt against Assange and diverted from the real target: his Wikileaks reporting.
Assange and Chelsea Manning exposed rape, torture, and murder by the US-UK coalition: war crimes that we all urgently needed to know about. After the 2003 invasion and occupation of Iraq, we wrote an open letter, 'Neither Blood nor Rape for Oil', to every woman MP. We were alarmed that none even acknowledged it.
The witch-hunt against Assange invited women furious at the continuing neglect of rape by the criminal justice system to join that system against Assange. This manipulation is typical of how governments protect themselves while claiming to protect us. It proved irresistible to many.
Contrast the determination to get Assange – the work hours and millions of pounds over 10 years – with the deadly lack of state protection for most victims of violence. While rape and domestic abuse soar, even faster under the coronavirus lockdown, they have been practically decriminalised. Women have had to campaign to expose police and CPS trawling through victims' social media and sexual history to discredit them and drop their cases. The lucky 1.5% of reported rapes that ever reach court may have waited four years to get there.
If the government was serious about rape and domestic violence, it would make sure the police, CPS, and courts – both criminal and family – prioritise victims regardless of race, age, class, immigration status, or relationship to their attacker. They would increase benefits, resources and services women need to protect themselves and their children, and extend them to all women, including immigrants and asylum seekers excluded by the 'no recourse to public funds' rule.
They would end the 'presumption of contact' which enables violent men to use the family courts to continue their reign of terror against women and children and avoid prosecution. They would stop accusing mothers of 'parental alienation' when they report child abuse by violent fathers. And they would stop prosecuting rape victims they refuse to believe.
Much of this could be addressed in the Domestic Abuse Bill currently in the House of Lords. But the government has resisted amending the bill as demanded by women's organisations. Instead, they promote the Covert Human Intelligence Source (Criminal Conduct) Bill and Overseas Operations bills which would enable rape, torture, and even murder by anyone the state gives a licence to, including corporations. The war crimes that Assange and Manning found proof of and publicised would be legalised and extended to UK soil.
Help us to get basic protections in the Domestic Abuse Bill and join the mounting opposition to the so-called Spy Cops and War Crimes Immunity bills.
Lisa Longstaff
https://www.thecanary.co/letters/2021/01/10/letter-the-demonisation-of-assange-paves-the-way-for-more-rape-and-murder-by-the-state/
Categories In the Media, Latest News Post navigation
SNS speaking at webinar: can social workers be activists? 8 Dec
'Spy Cops' Bill – Report Stage in the House of Lords

redpajama_set_name: RedPajamaCommonCrawl


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A "picture is worth a thousand words" but you'll never have as much fun as you will by seeing me live in the flesh.
To watch me live on cam you will need Yahoo Messenger, Click the "DOWNLOAD YAHOO" link below for the latest version.
Once you have Yahoo Messenger installed, give me a call tell me your Yahoo ID and I will invite you to view my cam!


Philips 881 ₱ 752.00 Philips Standard range provides the same Original Equipment quality as the lights we provide to automakers around the world. The Philips Standard range offers an excellent value for every application.
Philips 230359 ₱ 798.00 This Philips 13-watt Soft White Fluorescent light bulb brightens laundry rooms, bathrooms, kitchens, and offices. Versatile for multiple applications, this 2700-Kelvin Fluorescent bulb is suitable for indoor, commercial, and residential use and may be used in surface-mounted down light fixtures and recessed cans. Features a 4-Pin G24Q-1 Base. Low-mercury design creates a smaller environmental footprint. Philips reuses as much glass and packaging material as possible, reducing environmental impact. Lamp life of 10,000 hours. This product ships as a single bulb and comes with a 1-year warranty.


text:
/*-----------------------------
	Path Animator v1.1.0
	(c) 2013 Yair Even Or <http://dropthebit.com>

	MIT-style license.
------------------------------*/
function PathAnimator(path){
    if( path ) this.updatePath(path);
	this.timer = null;
}

PathAnimator.prototype = {
	start : function( duration, step, reverse, startPercent, callback, easing ){
		this.stop();
		this.percent = startPercent || 0;

		if( duration == 0 ) return false;

		var that = this,
			startTime = new Date(),
			delay = 1000/60;

		(function calc(){
			var p = [], angle,
				now = new Date(),
				elapsed = (now-startTime)/1000,
				t = (elapsed/duration),
				percent = t * 100;

			// easing functions: https://gist.github.com/gre/1650294
			if( typeof easing == 'function' )
				percent = easing(t) * 100;

			if( reverse )
				percent = startPercent - percent;
			else
				percent += startPercent;

			that.running = true;

			// On animation end (from '0%' to '100%' or '100%' to '0%')
			if( percent > 100 || percent < 0 ){
				that.stop();
				return callback.call( that.context );
			}

			that.percent = percent;	// save the current completed percentage value

			//  angle calculations
			p[0] = that.pointAt( percent - 1 );
			p[1] = that.pointAt( percent + 1 );
			angle = Math.atan2(p[1].y-p[0].y,p[1].x-p[0].x)*180 / Math.PI;

			// do one step ("frame")
			step.call( that.context, that.pointAt(percent), angle );
			// advance to the next point on the path
			that.timer = setTimeout( calc, delay );
		})();
	},

	stop : function(){
		clearTimeout( this.timer );
		this.timer = null;
		this.running = false;
	},

	pointAt : function(percent){
		return this.path.getPointAtLength( this.len * percent/100 );
	},

	updatePath : function(path){
		this.path = document.createElementNS('http://www.w3.org/2000/svg', 'path');
		this.path.setAttribute('d', path);
		this.len = this.path.getTotalLength();
	}
};


text:
Q: ldap + oidc + jwt node js I have a project about authentication with ldap using openid connect and generate a jwt with node js.
My knowledge:
1 ldap is a directory service allow the sharing of information about users, systems, networks, services, and applications throughout the network
2 OpenID Connect (oidc) is an authentification system based in Oauth2.0 (which is a delegation of authorization) by generat jwt.
3 jwt is a token contient crypted information about user,jwt is just a way to  convey information between tow parties ( ldap where data stocked and our backend).
My questions:
1 I'm using ldap apache directory studio where the attributes like cn (cn= common name) are unique but we can find many users have the same name so how I can change it and set the email to be unique?
2 How oidc generates jwt ? Is it automatically and how? Or do I have to build it?
3 How can I connect ldap with oidc? Or oidc have to be connect with my backend ?


text:
Q: Is short-polling less resource-intensive than message queues? I currently have an API running that delegates an ingestion job to a short polling bash script. I wan't to know if using something like the native adapter of strongMQ would consume less resources than the short-polling implementation.
https://github.com/strongloop/strong-mq
If message queuing is less resource-intensive than short-polling how exactly is this possible considering that an implementation of a message queue is a separately running microservice which is yet another node-process or "cluster" running on the operating system.

A: It comes down to polling frequency and the overhead for each poll.
If you aren't polling very frequently, then it may consume less resources to do something like a bash script in a crontab because the resources are only consumed during the poll.
If you are polling so frequently that your polling script spends more time running than sleeping, then it may make more sense to use something like a message queue and pay a smaller but more constant overhead tax.
"short polling" using a shell script
Each cycle involves starting a bash process, and that bash process forks off a handful of child processes to perform tasks like reading a file and running the results through grep, then you've got some measurable overhead. If the result of the checks are positive, you fork off some other script or process to perform the queued action.
message queue polling
Each cycle involves inspecting a value in memory against some sort of conditional. If the condition is met, send a notification message/packet to a connected client. The client then performs whatever action was queued.


A big bawdy barrel of laughs starring Owen Money as Buttons. 18+.
no longer talking to the oppressor. 16+.
Filled with outlandish characters, adventure galore and an upbeat score.
Take a trip back to the electric 80's and embark on a summer of love and smash-hit classics. Hair was big! Shoulders were padded! Mobiles weighed a tonne!
Join us for the ultimate celebration of the biggest disco floor fillers ever!
Come join us for "One night in Dublin" and be transported to 'Murphys Pub' where the house band, The Wild Murphys, will be performing great Irish songs.
It has been a while, but the multi-award-winning Welsh comedian is back, with a brand new live show! 16+.
The Eagles tribute returns in 2019 for another outstanding show promising more of their trademark musical prowess, acute attention to detail, and incredible showmanship.
It's time to Spice Up Your Life! and celebrate the return of the greatest girl band in the history of British Pop.
They're back! Beach Boyz Tribute Band is back in town.
Makers Of Dance Energy - 20 Years Anniversary.
The Music of the Four Seasons & Frankie Valli.
By Julia Donaldson and Axel Scheffler. Presented by Freckle Productions and Rose Theatre Kingston.
The Rolling Stones Story promises you an unforgettable Jumpin' Jack Flash back in time! It's Only Rock 'n' Roll, but we like it!
The Story Of Neil Diamond.
The Dreamboys are back and hotter than ever on their UK Tour 2019. 18+.
Bay City Rollers icon Les McKeown is on tour, bringing his fantastic show back to Swansea Grand Theatre!
Romesh is back with a brand new show 'The Cynic's Mixtape', his most brutally honest show yet. 14+.
How to be Human: The Show. 16+.
'The Days of Their Lives' - Tribute To The Legend.
I'm A Celebrity Winner...Harry Redknapp comes to town!
Once again Chris returns to his favourite theatre.
'Provocative, remorseless, and very, very funny' Times. 16+.
Hot off the heels of Cinderella, next year's swashbuckling Swansea Grand pantomime will be the high-flying pirate adventure, Peter Pan.
Without doubt the most explosive 60s show touring the UK, returns to Swansea for one night only.
Get On With It. 16+.
Now seen by over 1 million people worldwide!


The Government released the Interim Report of Commission of Inquiry into the Construction Works at & near the Hung Hom Station Extension under the Shatin to Central Link Project today.
In its interim report, the commission determined that the Hung Hom Station Extension diaphragm wall and platform slab construction works were not executed in accordance with Contract No. 1112 in material respects, but they are safe and it is not necessary to rebuild or conduct strengthening works.
Commenting on the interim report at a press conference today, Chief Executive Carrie Lam said the commission's determinations have relieved public concern.
"The commission's determinations have understandably assuaged our concern during the past few months about the structural safety of the relevant construction works.
She accepted the advice of Secretary for Transport & Housing Frank Chan and his colleagues that the Mass Transit Railway Corporation should continue to implement its proposed holistic assessment strategy for the Hung Hom Station Extension, aiming to complete it as soon as possible.
Mrs Lam emphasised despite the interim report concluding that the construction works are safe, the Government will still call for full accountability concerning the incident.
She said the Government expects more than just safety, with quality, integrity and compliance being prerequisites for any works.
Meanwhile, the commission has reviewed the adequacy of the MTR Corporation and the Government's management systems and has made recommendations in respect of promoting public safety and assurance on quality of works.
Also speaking at the press conference today, Mr Chan said the Government will study the commission's views and recommendations on the Government's monitoring mechanism thoroughly and will follow up with improvements.
To rebuild the public's confidence in railway projects, the Government will learn from the experience of this incident and make improvements, he added.
Several parts of the interim report have been redacted based on legal consideration, to avoid any prejudice to any ongoing criminal investigations and potential prosecutions of future criminal offences.
The Government will release the full interim report after the relevant criminal investigations and prosecutions have concluded.
Click here for the interim report.


Sunday night, stars of Netflix's upcoming Marvel series "Luke Cage," Mike Colter and Simone MIssick paid a visit to AMC's 'Geeking Out' show hosted by Kevin Smith and Greg Grunberg.
The extensive interview covered everything from how the two were cast, filming in Harlem, the stunts involved, the influence of Black Lives Matter, and how the iconic comic book costume gets a brief nod in the show.
The show also stars Alfre Woodard (Mariah Dillard), Rosario Dawson (Claire Temple), Theo Rossi (Shades), and Frank Whaley (Rafael Scarfe).
'Marvel's Luke Cage' begins streaming on Netflix this Friday, September 30.
Watch these two segments below and you can watch the entire episode here. 'Geeking Out' airs Sunday nights after 'Fear the Walking Dead' on the AMC network.


A 39 year old woman presented to her primary care physician complaining of acute mid back pain and difficulty breathing. The physician prescribed a pain reliever and told her to go to the emergency room if her symptoms worsened. Two days later she presented to the emergency room with the same symptoms and was diagnosed with a muscle strain. Two days after that she returns to the same emergency room with severe weakness in her lower legs. The emergency room is very busy so she leaves and goes to another hospital emergency department. There, after 8 hours, she is diagnosed with Guillan Barre Syndrome and told to return to the prior hospital for treatment. The patient returns to the prior hospital, is seen by a neurologist who diagnoses her with an epidural abscess, and immediately takes her to surgery. Unfortunately, too much time had passed to prevent permanent spinal cord injury as a result of the failure to timely treat and diagnose her epidural abscess. The patient is permanently paralyzed below the waist. A civil action against her treating physicians and both hospitals resulted in a settlement for $4.2 million.


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Betting On AFC East Online
Betting On Miami Dolphins Online
With a rich history of success, the Miami Dolphins are considered one of the most storied franchises in professional football. The Dolphins — founded in 1966 — won a pair of Super Bowl championships under head coach Don Shula in 1972 and again in 1973. It's the last time the Dolphins won the Super Bowl, however the club has captured five AFC crowns and 13 AFC East division titles. Miami went eight years without making a playoff appearance until the 2016 season when the club snapped its longstanding draught. [+]
When you think of the Miami Dolphins, the first name that comes to mind is Dan Marino. The Hall of Fame quarterback is arguably the best pivot to never win the Super Bowl, although Marino came close in 1984 when he guided the Dolphins to the championship against the powerhouse San Francisco 49ers. Despite leading after the first quarter, the Dolphins went on to drop the game 38-10.
Marino capped off a remarkable career with nine Pro Bowl appearances and was a three-time first-team All-Pro. He was named MVP in 1984 in his second season in the NFL.
Miami plays in the AFC East along with the New England Patriots, Buffalo Bills and New York Jets.
Miami Dolphins Next Regular Season Game
How will the Dolphins fare in the their next game? Before placing any wagers, be sure to know the team's opponent and all the up-to-date game betting lines.
My Team's Next MatchMiami Dolphins
Miami Dolphins Game Schedule
Check the schedule to gain a better sense of how you should place your wagers throughout the season. You'll be able to mark the games you feel will reap the biggest betting benefits.
Results / FixturesMiami Dolphins
What Are The Current Miami Dolphins Standings
Can the Dolphins bring an end to their longest playoff drought in franchise history? The answer to the question lies in the standings table below.
StandingsMiami Dolphins
Miami Dolphins Online Betting Tips
The Miami Dolphins' ground game ranked among the best in the National Football League in 2016. With primary back Jay Ajayi running for 1,272 yards, the Dolphins finished ninth overall in rushing. In fact, most of Miami's 5,324 total offensive yards came on the ground — something the team will need to address heading into the 2017 campaign.
Quarterback Ryan Tannehill is looking to rebound after a tough season in which he racked up a career-low 2,995 yards passing to go along with an abysmal 67.1 completion rate. Tannehill tossed 19 TD strikes while throwing 12 interceptions during the 2016 regular season.
The Dolphins were still able to clinch a playoff berth in what is becoming the weakest division in the NFL after the New England Patriots. Miami was a much better team at home in 2016, posting a 6-2 record at Hard Rock Stadium. The Dolphins were 4-2 against division opponents and 7-5 against AFC Conference teams.
There's definitely room for improvement on the defensive side of the ball for the Dolphins, who gave up on average 23.8 points per game. That was
Miami finished with a 10-6 record but many sportsbooks are indicating it could be a rough year for the Dolphins. BetOnline has set Miami's projected win total at 7.5, but can the Fish repeat the same success from 2016? The Dolphins will benefit from an easier schedule to start the season as they will face the Buccaneers, Chargers and Jets in the opening three weeks.
The Dolphins will open the 2017 campaign as +6600 dark horses. Only the Cleveland Browns, San Francisco 49ers, New York Jets, Los Angeles Rams and Buffalo Bills have worse odds.
Where Can I Bet On Miami Dolphins Online
Ready to put your money on the Miami Dolphins? Here are several online sportsbooks to consider before placing your wagers.
Online Site
#1 50% READ REVIEW BET NOW
#4 100% READ REVIEW BET NOW
#5 $500 READ REVIEW BET NOW
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Betting On Buffalo Bills Online
Betting On New England Patriots Online
Betting On New York Jets Online


Are you finding a Bluetooth speaker with perfect sound? Looking for a beautifully integrated LED display?
Now we have this Shunpad S - R100 Bluetooth speaker which features perfect stereo audio and multi-functional operations.
Powered by four 10W drivers, distortion-free at maximum volume. Super bass stereo soundbar, noise reduction effect, which will bring you the best listening enjoyment.
Set it under the television or mount it on the wall for a convenient and elegant setup, its excellent appearance will uplift your lifestyle, perfect for your home.
1. Please store in dry places, prohibit putting in water or too humid places.
2. Do not disassemble the product to prevent electric shock.
Let me start and say Xiaomi and Samsung you have competition.
Excelente coluna com boa qualidade de construção, som magnífico embora com alguma distorção sonora nos graves, contudo em relação a preço / qualidade é um excelente produto.
I bought this soundbar and is realy good your sounds like.
I did a good purchase.
hi what about Fm radio function?
This product is TV soundbar, no FM radio.
Can this connect to a subwoofer?


The Psychology Department (https://www.rhodes.edu/psychology) at Rhodes College invites applications for a tenure-track assistant professor to begin Fall of 2019. Candidates with degrees in Clinical Psychology, Health Psychology, or related fields in psychology are encouraged to apply. Rhodes Colege is especially interested in attracting candidates who are gender/sexual minorities, from historically underrepresented groups, and/or those with demonstrated commitment to working with diverse and historically underrepresented populations. Special consideration will be given to candidates whose program of research focuses on health and/or social equity, particularly health and mental health experiences and/or disparities related to race, ethnicity, sexual orientation, gender entity, disability, socioeconomic status, or other characteristics related to discrimination or exclusion. The successful candidate must demonstrate a firm commitment to teaching and scholarship at a liberal arts lege and will be expected to maintain an active research program involving undergraduates. Collaborative research and teaching opportunities exist with several interdisciplinary programs (https://www.rhodes.edu/content/majors-minors), including Gender and Sexuality Studies, Africana Studies, Latin American and Latinx Studies, Urban Studies (Urban & Community Health concentration), Neuroscience, and Educational Studies. Teaching responsibilities will include five courses a year which may include introductory psychology, statistics, upper-level research and seminar courses in the candidate's area of specialization, and content courses related to clinical, social equity, or health psychology. Research will be supported by start-up funds and lab space, and possibilities for additional research support include summer research funds and travel funds. In addition, extensive opportunities for collaborative research are available through our partnerships with OUTMemphis, St. Jude Children's Research Hospital, University of Memphis, University of Tennessee Medical School, and Le Bonheur Children's Hospital. Candidates must have completed all requirements for a Ph.D. in Psychology by July 2019.
Founded in 1848, Rhodes lege is a highly selective, private, residential, undergraduate lege, located in Memphis, Tennessee. We aspire to graduate students with a lifelong passion for learning, a compassion for others, and the ability to translate academic study and personal concern into effective leadership and action in their communities and the world. We encourage applications from candidates interested in helping us achieve this vision.
Rhodes College values an inclusive and welcoming environment. We are an equal opportunity employer committed to diversity in the workforce.
Please apply online at jobs.rhodes.edu. A complete application will include a cover letter that addresses your interest in teaching at a liberal arts lege, a curriculum vitae, a statement of teaching philosophy, a research plan, and three letters of recommendation. The application will also include a separate statement that addresses how your work and experiences might contribute to a lege community in which a commitment to diversity and inclusion is one of its core values. Review of completed applications will begin on October 1 and continue until the position is filled. The online application system will solicit letters of recommendation electronically from the candidate's recommenders, once their contact information has been entered by the candidate and all other required application materials have been submitted. Background checks are required before candidates can be brought to campus for interviews. For further information please contact Dr. Katherine White,whitek@rhodes.edu.


Hex Spell. For 5 seconds, target foe is hexed with Wastrel's Demise. Each second while hexed, target foe and all foes adjacent to that foe take 1...8...10 damage and an additional 1...8...10 damage for each second this spell is in effect. This hex ends prematurely if target foe uses a skill.
Hex Spell. (5 seconds.) Each second while hexed, target foe and all foes adjacent to that foe take 1...8...10 damage. Foes take +1...8...10 damage each second this hex is in effect. Ends early if target foe uses a skill.
The bonus damage begins to apply after the first damage pulse.
Often used with Psychic Instability.
Useful to cover other hexes that punish foes for using skills, such as Diversion or Shame, forcing your target to choose between taking the damage or suffering the covered hex's effect.
However, this skill does not cover other hexes if the target uses their own hex removal skill, since activation of the hex removal will end Wastrel's Demise, allowing the skill to remove the next hex in the effects monitor.
This skill is very effective against targets that do not use skills (e.g. minions or pets) or rarely use them (e.g. The Jade Quarry Carrier Juggernauts and Hauler Turtles activate their skill, Carrier Defense, under limited situations); it does the maximum damage against them and adjacent foes.
Heroes will preferentially use this on casters.
Anomaly.If the hex is reapplied before it ends, Wastrel's Demise will continue to add up the bonus damage until the first hex would have run out. After that, the bonus damage cycle will start over.
Wastrel's Demise and Savannah Heat are the only two skills for which damage over time increases over their duration.
This page was last edited on 26 July 2018, at 15:10.


My name is Darius and I restore license plates. I am a member of (ALPCA) The Automobile License Plate Collectors of America # 12117. I got into the hobby a few years ago after watching too many American Pickers. I decided to give it a shot. I thought it would be neat to bring back a 80,90, even a 100 year old object back to life. I researched all over the internet and everywhere else, I asked people at car shows, and no one had a solid technique for restoring these. The ones I did find restored were in my opinion poor quality. There are other methods out there but there are messy and way too time consuming. After countless trial and error I finally figured out a way to restore beautiful license plates back to better than new. I then moved on to old embossed street signs and had the same results. Anyone can do this. You don"t have to be a skilled artist, just someone willing to put a little time and effort into this. There is another booklet for sale on for around $25, I ordered it and tried it, and found out that the quality was just not there. Instead of charging people $25, I am selling a .pdf file of my book for only $14.95. If you want a hard copy I can print it and mail it for $22 anywhere in the US. Give it a shot. It really is a neat hobby and very stress relieving. The results in these pictures speak for themselves. I will email you a .pdf copy of my 20 page book within 24 hours. And by the way, my book is step by step, with pictures included, unlike the other books out there for sale. Thanks for the opportunity and wish you luck !


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INDIANOLA: Groove with Rick Allyn and Friends
Sun | West Sound A & E
— Apr 16th, 2004
North Kitsap's own Rick Allyn Band invites you to get out of your seat and boogie down Saturday at the Clubhouse in Indianola.
The band will perform its own brand of rock and R&B, including originals by leader Rick Allyn of North Kitsap. Influences on the band range from Van Morrison, to later Eric Clapton, B.B. King and Motown artists.
Other members of the band include Markus Duke (keyboards), Robbie Morshead (drums, percussion and vocals), Dave Schott (drums, lead and backing vocals) and Stuart Wakefield (bass guitar and backing vocals). All band members have lengthy experience in the music industry. Duke formerly played in Lou Rawls' band, and Morshead played back-up for Bo Diddley. All but Duke, a Seattle resident, hail from North Kitsap.
Catch the Rick Allyn Band 8:30 to 11:30 p.m. Saturday at the Clubhouse in Indianola, 20446 Indianola Road NE. Cost at the door is $7, with munchies and beverages included. This is a nonalcoholic event.
West Sound Music
FRIDAY NIGHT JAM, Hot Shots Java, 18881-B Front St., Poulsbo, (360) 779-2171: acoustic music, all genres, vocalists welcome; 7 p.m. SECOND FRIDAYS : POULSBOHEMIAN COFFEEHOUSE, 19003 Front St., Poulsbo, (360) 779-9199, www.silverlink.net/pbch: Celtic-flavor fiddle jams with guitars and drums playing reels, jigs, waltzes, polkas; ... [Read More...]
Miss Kingston applications pending Applications are due May 18 to compete in the Miss Kingston pageant planned for August. Contestants must attend school in North Kitsap School District, be between 15 (by May 1) and 18, have at least a 2.5 grade-point average and live in North Kitsap ... [Read More...]
Fire Destroys Driftwood Fort Indianola Fire consumed a beach fort made of driftwood Wednesday morning near Indianola. No one was injured. North Kitsap Fire & Rescue firefighters arrived at the beach between Jefferson Head and Camp Indianola around 5:30 a.m. Wednesday after camp ... [Read More...]
Allyn To Host Annual Festival This Weekend
The 23rd annual Allyn Day Festival and Salmon Bake, sponsored by the Allyn Community Association, will open with entertainment at 10 a.m. Saturday at the Allyn Waterfront Park. The salmon feed will run from noon until the food is gone, at a cost ... [Read More...]
Yes changes up concert visuals, musical content
The band Yes plays with a spectacular stage show in Belgium. The five original band members will perform at Seattle's KeyArena. Courtesy photo It used to be hard for Yes fans. They had to worry about whether the band ever would muster up ... [Read More...]


Text post - This could be thought leadership, teaching a concept, a story, an update, or idea with your audience.
Links to articles - As you find interesting articles on the internet, share them with our team and we will put together short captions that tease the article and position you as a thought leader and curator.
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If you choose to go with the "Audience Growth" package of our Daily content offering, then we will also add new Linkedin connections to your account on a daily basis to help grow your audience and ensure we get your content in front of more of your ideal customers.
You can subscribe to Lead Cookie Daily Content with two different options. Details on both are outlined below.
You can monthly save 10% if you pay for 3 months up front.
You will have an account manager who runs and handles your Linkedin account for you. Every day they will clean out your Linkedin inbox and send you updates and action steps for any leads you need to follow up with.
We will first hold a 90 minute onboarding call to get clear on understanding your business and who you are targeting. After that call, we will send you Linkedin scripts and strategy via a Google Doc where we can collaborate on script changes.
Once everything is approved, we will get your campaign started. Typically there is a two week delay between your onboarding call and starting your outreach.
During this time, we will also provide you with a video training course called "How to convert Linkedin Leads to Phone Calls". This course is meant to help you optimize your responses and help you gain more value from our service.
Once you are ready to get started, please notify your primary contact and they will send over details on next steps to get started.


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Tag: roundup
Books of the Year: 2017
This year, so far, I've read 175 books. That's a lot to choose from, but I've managed to narrow down my top choices for the year to eleven. These are THE books: the ones I can't stop thinking about, have been recommending for months, and still get something new from, every time I reconsider them. There were many, many others that I loved and thought were brilliant (they're listed at the bottom of this post). Some titles have been left off on the grounds of ubiquity: Lincoln in the Bardo, The Underground Railroad and The Power were all incredible books which I adored, but they don't exactly need any more attention or admiration. These eleven are my absolute hands-down all-stars, and some of them, I think, deserve a bit more love. So here they are.
For A Little While, by Rick Bass. Bass is criminally unknown in this country. He writes the most beautiful, most complete short stories I've ever seen: each one is like a novel, feeling full with incident and characterisation and yet never going on for too long. His geography is the American West and Midwest, but unlike other writers of whom he reminds me (Flannery O'Connor, Cormac McCarthy) he is unfailingly humane to his characters. Reading him is an absolute treat. (short review)
2. Days Without End, by Sebastian Barry. Speaking of McCarthy, Barry's novel reminded me of a gay-er, more tender and humane and frankly normal, riff on Blood Meridian. Barry too writes about the violence visited upon Native Americans by whites, but he does so in the context of the US Civil War and as part of the love story between his two male protagonists, Thomas McNulty and John Cole. His sentences are stunning, and he absolutely nails the dynamic of silent, undemonstrative love between men.
3. Sand, by Wolfgang Herrndorf. My initial impression of this stands: it's like a Graham Greene novel and an Ian Fleming novel had a baby, then left the baby to be raised by the Coen Brothers. Dark, funny, nihilistic and magnificently disdainful of narrative convention, it's a spy novel set in 1970s Morocco that manages to completely baffle you half a dozen times. The ending is unforgettable. (full review)
4. Do Not Say We Have Nothing, by Madeleine Thien. Of all the books I read this year, this is one of the most sophisticated. Juggling the stories of several young Chinese musicians at Shanghai Conservatory during the Cultural Revolution, it manages to be an overview of twentieth-century Chinese history, a family saga, and an examination of the ethics of making art under tyranny, without ever losing nuances of characterisation. Good though The Power is, this was my favourite to win the Baileys Prize. (short review)
5. The Fact of a Body, by Alexandria Marzano-Lesnevich. This is the single book that I wish I had pushed on more people this year. It's a hard sell, because it is about Marzano-Lesnevich's investigation of the case of Ricky Langley, who is in prison for molesting and murdering a six-year-old boy. She interweaves his story with her own—including her childhood molestation by her grandfather—and creates a compelling, frightening, beautiful book out of it, tackling the meanings of innocence, of justice and of redemption. I think it is utterly stunning.
6. Reservoir 13, by Jon McGregor. Everyone has been talking about this book. No prize jury has yet seen fit to reward it, which is bonkers; it's a book with no narrator, which ignores the conventions of the missing-girl genre as well as those of traditional nature writing, resulting in an extraordinarily compelling jigsaw of life in a rural village shaken by tragedy over the course of thirteen years. It takes almost inconceivable skill to write such a thing, and I urge you to pick it up if you haven't already. (full review)
7. The Time Of Our Singing, by Richard Powers. This book is absolutely astonishing. Its protagonists are mixed-race (African-American-Jewish) brothers Jonah and Joseph, a concert pianist and an operatic tenor, but it is so much more than an insider's classical music novel; it is ambitious enough to take on twentieth-century American history, inter-racial marriage, deep questions of belonging and vocation and family and home, and Powers simply writes so intelligently and thoughtfully. (It will also give you a whole Spotify playlist of stuff to listen to, if that's your jam.) It is now on my shelf of Books To Save From Fire. Can't say better than that.
8. It, by Stephen King. Rarely, if ever, have I been so pleasantly surprised by a book. King's exploration of small-town horror and mundane evil is over a thousand pages long, but, reader, they will fly by, I promise you. His sexual politics are awkward and dated, but you can tell he was trying, and I don't think I've ever encountered another author who—at his best—is so damn readable while still keeping rhythm and flow in his prose. Make time for this book. (full review)
How about this cover. Maybe my favourite of the year.
9. Borne, by Jeff VanderMeer. The sci-fi book I have been recommending to everyone who doesn't like sci-fi. Set in an industrially ravaged future city menaced by an enormous flying bear (go with it), it tells the story of scavenger Rachel, who lives with her partner Wick in an abandoned tower block, and who finds a small lump of biotech one day on her searches. She takes it home and names it Borne, and quickly finds that the extent of Borne's abilities—and his true nature—are way beyond her expectations. It's a lot of things rolled into one: a suspense thriller, a mother-and-child story, a tale of friendship, a sort of romance. VanderMeer's imagination, and ability to translate his ideas into strong visuals through prose, is peerless.
10. The Diary of a Bookseller, by Shaun Bythell. In the same way, I imagine, as the medical profession thanks its various divinities for Theodore Dalrymple, Henry Marsh, and Adam Kay, so are booksellers offering orisons for the work of Shaun Bythell. At last, someone who is lifting the curtain on the ridiculous/rude/implausible/plain stupid things, customers, and situations that booksellers deal with daily. And you don't have to be in the industry to appreciate the man's witty misanthropy. We keep selling out of this in the bookshop, sometimes within the same day of a fresh delivery.
11. Dodgers, by Bill Beverly. This is one of those books that you almost cannot talk about, because to do so is to disturb the complex feelings of awe and sorrow and emptiness and fullness that settle, all at the same time, upon you once you finish it. It is indisputably a crime novel, but oh it is so much more. East, our protagonist, is a fifteen-year-old lookout at an LA crack house. He fucks up, and is given a chance to redeem himself: take a roadtrip with some other fuck-ups, and his preternaturally brutal younger brother Ty, to assassinate a federal judge in Wisconsin. There is so much brilliant thinking and writing in this, about brothers and violence and despair and choosing the kind of man you wish to be. It deserves to be a classic.
Other books that were incredible: Every one of these titles is something I would urge you to read as soon as you can. Run, don't walk. Gnomon, by Nick Harkaway: viciously funny, insanely clever, on the potential consquences of a surveillance society. Sing Unburied Sing, by Jesmyn Ward: a stunning road trip novel; Ward is a modern William Faulkner. A Gentleman In Moscow, by Amor Towles: charming and witty, without ever losing intellectual complexity and nuance. Five Rivers Met On A Wooded Plain, by Barney Norris: if you loved Reservoir 13, this is your next stop; set in Salisbury and utterly breathtaking. English Animals, by Laura Kaye: beat Ali Smith to being the Most Timely Brexit Novel, and also a beautifully written depiction of class/power imbalance and a lesbian relationship. A Field Guide to Reality, by Joanna Kavenna: the dreamiest, oddest Oxford novel ever, taking in thirteenth-century medieval theories of reality and contemporary metaphysics, and really set apart by fantastic illustrations. The Underground Railroad, by Colson Whitehead: you know why. Black and British, by David Olusoga: my new favourite history book, dealing with the presence of free Africans in Britain long before the Empire Windrush. The Wardrobe Mistress, by Patrick McGrath: a compelling ghost story set in the freezing winter of 1947, in London's seedily glamorous theatre world. 2084, ed. George Sandison: some of the best sci-fi of the year, in the best-edited short story collection of the year. My Absolute Darling, by Gabriel Tallent: brutal and stunning, a contemporary McCarthy mixed with Daniel Woodrell. Balancing Acts, by Nicholas Hytner: engaging commentary on plays and staging, as well as some fun name-dropping; worth reading for his analysis of Othello alone. Lincoln In the Bardo, by George Saunders: it really is the most heartbreaking and risk-taking book, very worth reading. Night Sky With Exit Wounds, by Ocean Vuong: my favourite poetry book of the year, lush meditations on sex and heritage and allegiance. The Power, by Naomi Alderman: reading it is a mental game-changer; you won't think the same way again. Walkaway, by Cory Doctorow: an honest-to-God utopian novel, suggesting that the future might not suck if we work together and use tech productively. Like A Mule Bringing Ice Cream to the Sun, by Sarah Ladipo Manyika: a novella about a sexy, cosmopolitan pensioner, the kind of older woman we should all aim to be.
And I have to stop there—I could go on. Have you read any of these? Have I convinced you to pick up any?
Posted on December 16, 2017 by Elle	28
2016's Dishonourable Mentions
I was really lucky with my reading this year. Maybe it's because as I get older, I have a better sense of what I'm going to like; maybe it's the opposite and I'm just developing the ability to appreciate a wider range of writing. Whatever the reason, most of the books I read this year were not just good but really good, worth rereading at the very least—even the ones that didn't make my Best Of Year list. But…no year is perfect. Here are the few books that just completely misfired for me in 2016. (This is all, of course, highly personal and subjective. What didn't work for me may work brilliantly for you! And vice versa. I'll still try to explain, succinctly, why I felt these books faltered, but don't feel you need to take my word for it. All links are to my reviews, if you want to read more.)
The Expatriates, by Janice Lee
What's it about? The intertwined lives of three women living in Hong Kong: Hilary Starr, the childless stay-at-home-wife of an expat lawyer; Margaret Reade, whose youngest child went missing last year; and Mercy Cho, the childminder who was meant to be looking after the lost boy at the time of his disappearance.
Why didn't it work? From my review: "Over the course of the novel, all three women will come to understand and accept motherhood as the highest possible goal of a life—a conclusion which, couched as it is in a foreign setting and an occasionally melodramatic plot, could be overlooked on first reading, but which becomes increasingly uncomfortable the more you think about it."
Shylock Is My Name, by Howard Jacobson
What's it about? It's the second entry in the Hogarth Shakespeare series, which novelises and updates some of the Bard's most famous plays. Jacobson resets The Merchant of Venice in Cheshire's Golden Triangle, throwing celebrity footballers into the mix.
Why didn't it work? From my review: "It's not just the gross dehumanisation suggested by the use of the word "Jewesses" (though [the characters] Plury and D'Anton use it frequently); it's also that, basically, they've pimped a teenager, and none of the resulting brouhaha treats that as a big deal. Combined with Strulovitch's original pervy possessiveness, and the many approving references to Philip Roth, it just all made me hideously uncomfortable."
Ten Days, by Gillian Slovo
What's it about? The development of riots over the course of ten days in south London, as a result of a death in police custody. There are some clear parallels to the Tottenham riots of 2011.
Why didn't it work? From my review: "The problem may be that I've seen all of this before, and not too long ago at that, and done with greater flair: in House of Cards, obviously, but also in The Politician's Husband. (I hope other people remember that show. It starred David Tennant and Emily Watson, and aired in 2013. It was fucking devastating.) It's suggestive, I think, that both of those instances are television shows. I suspect that this is material we don't actually expect to read anymore; political machinations and back-room deals are the domain of the small screen now, and a good actor can raise a thinly written politician stereotype to a higher level, whereas a novel…well, a novel has to rely on its writing. The writing is all that a novel has."
The Improbability of Love, by Hannah Rothschild
What's it about? A down-on-her-luck woman working as a private chef finds a priceless Watteau painting in a junk shop; everyone from a Saudi sheik to a shady art dealer decides they want it.
Why didn't it work? From my Superlatives post: "It's a sweet idea but executed in a very Eat-Pray-Love sort of way. The main character's mother is an alcoholic and the conversations they have are so full of psychological jargon that I wasn't at all convinced two people would talk to each other like that. Also, Rothschild doesn't get contractions: all of her characters say things like 'I will' or 'You do not", instead of 'I'll' or 'You don't'. It's not for emphasis, either, and it happens for 404 pages, first to last."
Raw Spirit, by Iain Banks
What's it about? Banks, a famous science fiction writer but also a well-known lover of whisky, takes a road trip with several of his old drinking buddies to visit, and sample the wares of, every single-malt distillery in Scotland.
Why didn't it work? From my #20booksofsummer roundup: "This book suffers appallingly from two interrelated things: an excess of privilege, and a deficit of self-awareness. …There were times when so very little of this book had anything to do with whisky that it honestly felt like he was taking the piss. Like the five pages about a Jaguar he once had, followed by a cursory page and a half on a distillery's history and product. Or the long anecdotes about his friends and what they're like when they're drunk. Real talk: no one is a hilarious drunk to a stranger."
The Many, by Wyl Menmuir
What's it about? Timothy buys an abandoned fishing cottage in a tiny Cornish village and sets out to restore it, temporarily leaving his wife behind in London. But the village has its own secrets: the fate of the man who lived in the cottage before Timothy, the bizarrely etiolated fish being pulled from the sea, the identity of the mysterious grey-coated woman who buys every catch…
Why didn't it work? From my review: "The reality of reality, and the sanity of sanity, have long been uncertainties for authors to engage with. But the strength of a book lies in how satisfactorily it deals with those questions—it doesn't have to answer them, but it has to deal with them—and The Many doesn't deal with anything. It just shrugs and leaves. It's a mark of my frustration that, after finishing it, I realized I still had not the slightest clue what the title meant. The many what? Fish? Deaths? Portentous pronouncements by old Clem the winchman? I don't mean to sound bitter, but reading this book felt like being ghosted by someone on Tinder. There was so much promise here! What happened?!"
Diary of an Oxygen Thief, by Anonymous
What's it about? The supposedly non-fictional (but, thank heavens, clearly actually fictional) account of an alcoholic Irishman who, after years of recreational cruelty to women, gets a taste of his own medicine.
Why didn't it work? A lot of reasons, but this, from my review, might give you a clue: "The knowledge that this particular Irishman does not actually exist was, in places, the only thing that kept me reading. He is not very nice. You can gather this from the first sentence, and also from the part where he talks about purging himself of his sins against women. Handy hint: if you're a man and you want to purge yourself of your sins against women, you will never be able to."
The Countenance Divine, by Michael Hughes
What's it about? In 1999, a programmer working on a fix for the Y2K bug becomes entangled with a tradition of British millennarianism involving Jack the Ripper (in 1888), William Blake (in 1777), and John Milton (in 1666).
Why didn't it work? From my monthly Superlatives post: "The execution is so inconsistent (the sections set in 1999 are written in especially dull tones), and none of the book's internal logic is really conveyed to the reader. Also, it features what has to be the drippiest Messiah EVER. (Unless the actual Messiah isn't the character just referred to… Doesn't change the rest of the book, though.) Oh, and either the Apocalypse in this book actually does rely upon horrific violence against women, or Hughes hasn't sufficiently explained the reasons a reader should resist this interpretation. Which is such an old, and boring, story."
The Other World, It Whispers, by Stephanie Victoire
What's it about? A debut collection of fantastical short stories focusing on transformation, metamorphosis, and literal and figurative identity.
Why didn't it work? From my review: "I don't know, it's just a little too much, or not enough: the casual colloquialisms when the rest of the story is on a higher thematic plane ("didn't have any more cash on her"; "been sorted"), the tang of cliché ("gulped down", "lump in her throat"). It didn't work for me at all. …The story needs, in effect, a more judicious editorial eye. I know I say this a lot about contemporary fiction but I think it's true; there are many, many competent stories and novels being published which could have been excellent with a little more attention and criticism."
Did you read any of these this year? What did you think of them? Am I a lunatic fool for missing the point of The Many? Am I a horrid killjoy for wanting to roll my eyes on every page of The Improbability of Love? Let me know…
Posted on December 23, 2016 December 23, 2016 by Elle	18


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2000-06-13 Assigned to ECOSAFE, LLC reassignment ECOSAFE, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: PATTERSON, JAMES A.
2002-09-17 Assigned to BIOLIFE, L.L.C. reassignment BIOLIFE, L.L.C. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: ECOSAFE, L.L.C.
A method of arresting the flow of blood and other protein containing body fluids flowing from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a salt ferrate is provided for a unique use which, when hydrated after mixing with a victim's own blood or other aqueous media, produces Fe+++ thereby promoting clotting when applied in a paste form to the wound for a time sufficient to arrest substantial further blood and other body fluid flow from the wound. The compound is formed of a ferrate (VI) salt taken from the group consisting of H, Li, Na, K, Rb, Cs and Fr. However, to decrease or eliminate stinging sensation, the compound may be formed having a ferrate (VI) salt taken from the group consisting of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Al, As, NH4 and N(C4H9)4. The preferred composition also includes a cation exchange material such as sulfonated ion exchange resin as an admixture which, when combined with the ferrate (VI) salt, will hydrate in the presence of blood or other aqueous media to produce Fe+++, thereby promoting clotting of the blood and body fluid and to produce oxygen. The cation exchange material produces a scab or protective coating over the wound for protection and enhanced healing. Oxygen produced during the reaction substantially reduces the level of bacteria, virus and fungus at the wound. The compound must be stored dry unmixed together and mixed into a paste with the victim's blood or other aqueous media just prior to its application to the wound.
This is a continuation-in-part of Ser. No. 09/500,902 filed Feb. 9, 2000, now U.S. Pat. No. 6,187,347.
This invention relates generally to topically applied agents for promoting blood clotting to arrest blood flow from an open wound, and more particularly to a method of applying an anhydrous composition which may be mixed just prior to its application directly over an open bleeding wound or a wound from which body fluid is flowing to accelerate flowing blood and body fluid clotting and enhance healing.
In addition to conventional bandages, adhesive means, compresses and the like which are applied with pressure directly against a bleeding open wound, considerable effort has been directed toward the development of chemical agents in various forms which accelerate or enhance the coagulation of blood flowing from an open wound to arrest blood flow. Many of these agents are in the "clotting chain", i.e., fibrinogen, thrombin, Factor VIII and the like. Others are based upon the use of collagens. Edwardson, in U.S. Pat. Nos. 5,763,411, 5,804,428, and 5,962,026, for example, teaches the use of fibrin in conjunction with a solid support in the '411 patent, and as an enzyme free sealant in the '428 patent, and as a solid composition substantially free of catalytic enzymes.
Three U.S. Patents invented by Martin, U.S. Pat. Nos. 5,692,302, 5,874,479 and 5,981,606, are generally directed to the use of pyruvate in combination with fatty acids and an oxidant as a therapeutic wound healing composition.
Stilwell, in U.S. Pat. No. 5,484,913 teaches the use of calcium-modified oxidized cellulose to promote faster hemostasis. In U.S. Pat. No. 5,474,782, Winter, et al. teaches a wound healing composition or its salt present in a pharmaceutically acceptable carrier, the preferred embodiment being a salt of sodium. Winter provides a wound dressing with a taspine compound for promoting healing rather than clotting.
In U.S. Pat. No. 2,163,588, Cornish teaches a wound pad having very fine fibers carrying a viscous agent and a septic for arresting and clotting blood flow. Eberl, et al., in U.S. Pat. No. 2,688,586, teaches an improved hemostatic surgical dressing with alginic acid as a clotting agent. Masci, et al. in U.S. Pat. Nos. 2,772,999 and 2,773,000 also teaches hemostatic surgical dressing including a pad and free acid cellulose glycolic acid.
A patent for another hemostatic wound dressing is taught by Shelley in U.S. Pat. No. 3,206,361 having an active agent in the form of methylaminoacetocatechol hydrochloride. Likewise, Anderson, in U.S. Pat. No. 3,328,259, another wound dressing containing a film of cellulose glycolic acid ether is provided as the hemostatic agent.
The hemostatic agent taught by Sugitachi, et al. as disclosed in U.S. Pat. No. 4,265,233 is blood coagulation Factor VIII plus either fibrin or thrombin. A ready-to-use bandage is taught by Altshuler in U.S. Pat. No. 4,363,319 which also contains thrombin as an active agent, the bandage all of which is contained within a sealed package.
Invented by Lindner, et al., a wound pad which is impregnated with tissue-compatible protein such as collagen and lyophilized Factor XIII, thrombin and fibrinogen, are taught in U.S. Pat. No. 4,600,574. The use of collagen as a hemostatic agent within a pad that has been freeze dried is taught by Sawyer in U.S. Pat. No. 4,606,910.
In U.S. Pat. No. 4,616,644, Saferstein, et al. teaches the use of an adhesive bandage with high molecular weight polyethylene oxide applied to the surface of the perforated plastic film wound release cover of the bandage to arrest blood flow from minor cuts. Yet another hemostatic agent including a carrier in the shape of a flake or fiber having thrombin and Factor XIII affixed thereto is taught by Sakamoto in U.S. Pat. No. 4,655,211. The use of an ultra-pure, clean thrombin solution as a hemostatic agent is taught in U.S. Pat. No. 5,525,498 invented by Boctor. Two recent patents invented by Pruss, et al., U.S. Pat. Nos. 5,643,596 and 5,645,849 both teach the use of hemostatic dressings which incorporate thrombin and epsilon aminocaproic acid (EACA) and calcium chloride on gelatin.
An absorbable spun cotton-like topical hemostat is taught by Shimuzu, et al. in U.S. Pat. No. 5,679,372. This disclosure is directed to an absorbable dressing made of acetocollagen fibers which are innately adhesive to a bleeding surface. In a patent to Bell, et al, U.S. Pat. No. 5,800,372, a dressing made of microfibrillar collagen and a superabsorbant polymer provides both blood absorption and clotting inducement.
One embodiment of the present method utilizes an improved ion exchange resin, preferably in the form of a styrene divinylbenzene copolymer which has been sulfonated. The collective teaching of making this prior art resin is to be found in an earlier patent to co-inventor, Patterson, U.S. Pat. No. 4,291,980 which was based at least in part on the production of spherical beads comprised of copolymer styrene and divinylbenzene as taught in U.S. Pat. Nos. 2,366,007 and 3,463,320. This collective teaching is incorporated herein by reference. An improvement better adapting this resin to the present invention is in the form of substantially reduced cross-linking down to about 0.25%.
Another primary aspect of the present method incorporates a salt ferrate, preferably potassium ferrate (2K2FeO4). The teaching of a process for producing alkaline metal ferrates is taught by another co-inventor, Thompson, in U.S. Pat. No. 4,545,974. This teaching is also incorporated herein by reference.
It is submitted that the above-referenced prior art, either taken individually or collectively in any combination thereof fail to teach a method of preparing a flowing blood or body fluid clotting agent just prior to its application which includes an admixture of a salt ferrate which produces a trivalent Fe+++ ion which reacts with the blood to accelerate coagulation and clotting of the blood. Moreover, the utilization of an insoluble cation exchange material, e.g. a sulfonated ion exchange resin, in combination with the salt ferrate, additionally produces a protective covering over the wound and also produces oxygen which acts as an antibacterial, antiviral and antifungal agent. Further, the presence of selected salts neutralize hydroxide radicals as clotting occurs so as to eliminate any substantial stinging sensation.
This invention is directed to a method of arresting the flow of blood and other body fluid from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a salt ferrate is provided for unique use which is hydrated just prior to its use by mixing it into a paste using the victim's own blood or other aqueous media. Fe+++ is produced thereby promoting clotting of the blood and other body fluids when applied to the open wound for a time sufficient to effect clotting of the blood or body fluid to arrest substantial further flow from the wound. The anhydrous compound is formed of a monovalent, divalent, or trivalent salt ferrate (M2FeO4, M2′FeO4 or M2″FeO4) taken from the cationic group consisting of H, Li, Na, K, Rb, Cs and Fr. However, to decrease or eliminate stinging sensation, the compound may be formed having a salt taken from the cationic group consisting of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Al, As, NH4, and N(C4H9)4. The preferred composition includes the substantially anhydrous salt ferrate compound and a sulfonated ion exchange resin as an admixture which will hydrate in the presence of blood or other aqueous selected media to produce Fe+++, thereby promoting clotting of the blood and oxygen. The resin produces a scab or protective coating over the wound for protection and enhanced healing. Oxygen produced during the reaction substantially reduces the level of bacteria, virus and fungus at the wound.
It is therefore an object of this invention to provide a method of utilizing a salt ferrate as a blood clotting agent for arresting blood flow from an open surface wound.
It is another object of this invention to provide a method of arresting blood and body fluid flow utilizing a salt ferrate composition which is substantially sting-free when applied onto an open wound.
It is still another object of this invention to provide an anhydrous composition utilizing a salt ferrate combined with an insoluble cation exchange material and mixed with an aqueous media just prior to use for arresting blood flow from an open skin wound.
Still another object of this invention is to provide a method for preparing a localized rapid forming protective coating or covering just prior to its use that has antibacterial, antifungal and antiviral properties.
In accordance with these and other objects which will become apparent hereinafter, the instant invention will now be described.
The following is offered as a brief explanation of one possible mechanism which would explain the effectiveness of the present invention as described herebelow in full detail.
It is known that the decomposition of potassium ferrate produces the finest particles of iron oxide (Fe2O3) available. (See U.S. Pat. No. 4,545,974). Upon addition to water, K2FeO4 becomes Fe+++ in the form of FeOOH, which upon drying, yields Fe2O3. The FeOOH (or Fe2O3H2O) is a solid in suspension and this ultra-fine material seems to be an ideal irritant for platelet membranes, thereby releasing the prothroplastin that is needed to initialize clotting. It is possible that they may tend to rupture the platelets themselves, thereby causing a massive release of clotting factors as does the rough surface of a wound achieve the same end.
It is possible that the Fe+++ ion itself may aid in coagulation of blood. Trivalent ions, by lowering the zeta potential of a particle in solution, allow the particles (platelets) to clump more easily. Platelets are small disks of cytoplasm found in the blood of mammals. After a wound is received they begin to clump and stick around the wound area, causing the clumping and sticking of another cytoplasmic component, the thrombocycte. During this clumping process, certain phospholipids from the membrane of the platelets contribute to the overall clotting process, combined with the inactive plasma enzyme, Factor XII. Mechanical abrasion of the platelets is important in freeing the phospholipid component from the platelets.
One of the important results is the production of the trivalent Fe+++ ion which appears to be the beneficial clotting agent provided in this aspect of this invention. Moreover, it has been determined that the present invention acts on all body fluids containing protein, such as that which flows from an open skin blister or burn.
A broadening of this aspect of the inventive compound would be to substitute the potassium salt with others which possess the same cation properties as does the potassium cation. Those salt elements which will substitute for the potassium cation are shown in Tables I and II herebelow.
In addition to the above salts in the cation form, all zeolites, sulfonated coal, and natural reoccurring membranes such as protein membranes will also act in compound form with ferrate to release the trivalent Fe+++ ion to effect blood and body fluid coagulation.
In utilizing the K2 Fe O4 as above described to arrest blood flow from a bleeding wound, equation 3 shows the presence of hydroxide (OH)− radicals which are produced. The hydroxide (OH)− radicals remain present in equation 5 and cause stinging at the wound site. Moreover, all of the cation salts of Table I produce the same result, i.e. stinging caused by the presence of the hydroxide ion.
As can be observed from Equation 6, no hydroxide ions are produced. Rather, all are neutralized and combined with calcium as shown in the equation.
As provided by the above compounds, a method of arresting blood and body fluid flow from an open skin wound is provided. An effective amount of any of the above salt ferrates, and preferably potassium ferrate in powder form, is applied directly onto the wound to interact with flowing blood or body fluid to accelerate its clotting.
Although the above methodology and utilization of a salt ferrate greatly enhances blood clotting, the wound nonetheless remains opened and generally unprotected unless the salt ferrate is combined with a carrier such as a BAND-AID, bandage, cotton member and the like which has been impregnated or coated with a dry powder taken from of one of the above chosen salt ferrate compositions.
By the addition of an ion exchange resin R with the salt ferrate, an additional benefit of scabbing or depositing of a substance produced by the reaction with water in the blood is accomplished over the open wound. Details of the composition and method of producing the preferred ion exchange resin R in the form of styrene divinylbenzene are disclosed in the previously referenced patents and are herein incorporated by reference. As described in formulas herebelow, the resin R may be shown in its chemical form or generally designated by the symbol "R" for simplicity. The ion exchange resin R is sulfonated as is shown in chemical terms in each chemical equation herebelow.
When the preferred hydrogen form of this sulfonated ion exchange resin R is in the presence of the salt ferrate and water within blood, the following reaction serves to neutralize the hydroxyl ions produced in equation 3 above.
The K2 Fe O4 should be hygroscopic, small particles approximately 50 to 100 mesh size for best surface area. The ion exchange resin R is preferably in an acid form with some substitute Ca calcium ions as shown in equations 6 to 9. The cross linking of the resin R should be below 4.0 and as low as 0.25% and hygroscopic. The weight ratio should favor the dry ion exchange resin R by at least 4 to 1 of dry salt ferrate. The ion exchange resin R is preferably a cation exchange resin.
can supply excess of this ion to further induce blood clotting. The ferrate in contact with the blood-water on the skin forms O2 which is a strong disinfectant to the cut.
4. Even trace amounts of resin R in this admixture neutralizes hydroxyl ions to prevent stinging.
The cation exchange resin R was prepared in the washed hydrogen form, and then dried at 110° for 24 hours and powdered in grinder to about 100 mesh.
This composition was then applied directly to a fresh bleeding finger wound produced by a skin lancet having a penetration of 1.6-2.2 mm. The subject was 77 years old, skin condition non-flexible. Wound blood flow was at a rate of 0.206 g/30 seconds or 0.0412 g per minute to 0.0606 g per minute.
When a single penetration of the skin was made and blood flow started at 0.0412 to 0.0605 g per minute, application of 5 sec. of the above resin-ferrate composition directly to the wound dropped blood to zero as determined with a blot pickup of 0.0020 g within 1.0 minute. The resin-ferrate applied was on the order of 0.0175-0.0170 grams, forming a hard protecting sterilized coating over the penetration injury by the time that blood flow from the wound was stopped.
Dosage . . . 0.0174 g of anhydrous ferrate and resin admixture was used to treat wound.
At this dosage, a 30 g quantity of the composition will provide approximately 1724 separate treatments.
The above-described anhydrous compound is preferably in the form of a combination of potassium ferrate (K2FeO4) and the acid form of low cross-linked ion exchange resin particles. Both of the materials are in powder form and are stored together in an anhydrous form (no water). They have been previously applied directly to body fluids, i.e. blood, in the dry form (powder). Using this technique, this dry compound is difficult for control as to location of application and stability on a wound.
Certain chemical reactions slow down the blood clotting action and the production of beneficial O2. By controlling the neutralization of potassium hydroxide (KOH) by the acid resin, the mixing time and application time can be controlled. An aqueous media is used to mix the K2FeO4 and RSO3H. Thereafter, the mixture is spread on the wound to clot the blood and stop the bleeding. Mix time and spreading time total is about five minutes working time. The amount of aqueous media is just sufficient to form a spreadable paste when combined with the ferrate (VI) salt and resin. The lower the percentage of cross-linking of the resin, and the more resin used, the greater the amount of aqueous media needed.
(6) carbohydrate solution, i.e. sugar.
(4) heat (5° C.-30° C.).
Mix the resin and the K2FeO4. Then add the gelatin and mix. Within five (5) minutes, spread this paste-like mixture on the bleeding wound. The resin ferrate applied in this form controls bleeding.
Mix the resin and K2FeO4 with blood from a victim's wound and then apply this paste-like mixture to the wound from which the blood was previously obtained. Cover the wound evenly with the prepared paste mixture to control the bleeding.
B. applying said paste to the wound within a short time period of about five minutes after step A for a time sufficient to effect sufficient clotting of the blood to arrest substantial further blood flow from the wound.
said compound provided in Step A is formed of a salt ferrate (VI) of H, Li, Na, K, Rb, Cs or Fr.
said compound provided in Step A is formed of a said salt ferrate (VI) of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Al, As, NH4 or N(C4H9)4.
said compound provided in Step A is formed of a salt ferrate (VI) of H, Li, Be, Na, Mg, K, Ca, Rb, Sr, Cs, Ba, Fr, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Al, As, NH4 or N(C4H9)4.
said compound provided in Step A is K2 Fe O4.
said compound provided in Step A is formed of a salt ferrate (VI) which combines with water in the blood or aqueous media to eliminate substantially all hydroxide (OH−) which cause a stinging sensation.
D. forming a protective coating over the wound during Step B.
said compound provided in Step A is formed of a salt ferrate of H, Li, Na, K, Rb, Cs or Fr.
said salt ferrate provided in Step A is formed of a salt ferrate of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi Al, As, NH4 or N(C4H9)4.
said salt ferrate provided in Step A is formed of a salt ferrate of H, Li, Be, Na, Mg, K, Ca, Rb, Sr, Cs, Ba, Fr, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi Al, As, NH4 or N(C4H9)4.
said salt ferrate provided in Step A is K2 Fe O4.
said compound provided in Step A includes a salt which combines with water in the blood to eliminate substantially all hydroxide (OH−) which cause a stinging sensation.
said insoluble exchange material is a cation exchange resin.
B. applying said paste to the wound within a short working time of said paste of about five minutes and for a time sufficient to effect sufficient clotting of the blood to arrest substantial further blood or body fluid flow from the wound.
MXPA02010549A MXPA02010549A (en) 2000-04-28 2001-04-27 Hemostatic agent, method and carrier for applying a blood clotting agent.