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Ballyscullion Park, Derry
CONTACT: Rosalind Mulholland ADDRESS: Bellaghy Co. Derry
PHONE: 0044 28 79 386 235 FAX:
EMAIL: info@ballyscullionpark.com WEB: www.ballyscullionpark.com
Ballyscullion House
Ballyscullion Park
Lough Beg Views
The Walled Gardens
Ballyscullion Park is a beautiful historic house designed in 1840 by Sir Charles Lanyon in the Palazzo style.
The house is set in rolling parkland with breathtaking views over Lough Beg to Church Island and the Antrim hills.
Situated in the centre of Northern Ireland, 35 minutes from Belfast and 45 minutes from Derry/Londonderry, and half an hour from Coleraine and Cookstown, this central location makes it an ideal venue for weddings and parties.
Ballyscullion Park is situated on the shores of Lough Beg, through which the River Bann flows. It is a Ramsa site, and Site of Special Scientific Interest owing to the richness and diversity of flora and birdlife. At the southern end of the strand, surrounded by the Lough on one side and wetlands on the other, is the ancient historic monument, Church Island.
The original site of Ballyscullion Park was chosen in the late Eighteenth Century by Augustus Hervey, The Earl Bishop of Derry for his second palace in the county. The first, which is now in ruins, he built at Downhill on the north coast. The building of Ballyscullion began in 1789, to the Earl Bishops own extravagant designs. The façade was 350ft across, with a central rotunda flanked by curved wings with a large pavilion at each end. A double corkscrew staircase led from the entrance hall to the second storey circular drawing room which had panoramic views across to the Antrim hills in the east, the Mourne Mountains to the south and the Sperrin Mountains to the west. The present house was designed by Sir Charles Lanyon, and built in 1840 for Sir Henry Hervey Bruce

redpajama_set_name: RedPajamaCommonCrawl


The 2-walleye limit is needed to replenish the premier lake's fishery.
Perplexed by a complicated and underachieving Lake Mille Lacs fishery, the Department of Natural Resources said Tuesday that anglers can keep only two walleyes from the big lake when the state's open water fishing season begins May 11.
And Mille Lacs walleyes that end up in a live well or on a stringer must measure between 18 and 20 inches — though one trophy larger than 28 inches can be kept.
The limit is half what it was a year ago, when anglers on Mille Lacs — arguably the state's premier fishing lake — could keep four walleyes under 17 inches, with one over 28 inches.
The cutback is needed, the DNR said, because Mille Lacs walleyes are at a 40-year low.
Reproduction in the lake in recent years has been good, officials said, but too few of the fish are surviving. Consequently, conserving the lake's large 2008 walleye year-class — now 15 to 17 inches long — is important, because no strong year-classes follow it.
Without the new restrictions, anglers could exceed their "safe harvest quota" of Mille Lacs walleyes, which this year is 178,500 pounds — half the amount in 2012.
A quick rebound of the lake's walleyes is unlikely, DNR fisheries chief Dirk Peterson said.
"I think we're looking at least a two- to three-year period" that tighter harvest restrictions will govern the lake, he said.
Mille Lacs walleyes also are netted by eight Minnesota and Wisconsin Chippewa bands whose quota similarly was cut in half this year, to 71,250 pounds.
The bands again will net Mille Lacs during the spring spawn. But they're being encouraged "to balance [their harvest method]" in an attempt to make their take more "small-fish friendly," said Charlie Rasmussen of the Great Lakes Indian Fish and Wildlife Commission, which represents 11 Chippewa bands in Minnesota, Wisconsin and Michigan.
Among non-band members around the lake, Chippewa nets are widely blamed for the Mille Lacs walleye decline, a position also espoused by a new group called Save Mille Lacs Sportfishing (savemillelacssport fishing.org).
The group issued a statement late Tuesday saying it hoped to take the DNR to court and force an end to Chippewa netting.
But the DNR believes other factors might play roles, including the lake's larger northern pike and smallmouth bass populations, warming water temperatures brought on by climate change, the relatively recent arrival of invasive species such as zebra mussels, and possibly the agency's own Mille Lacs-specific harvest regulations.
The DNR also announced Tuesday that Mille Lacs smallmouth bass and northern pike regulations will be liberalized this season, in part as a way to entice anglers to keep coming to the lake.
Last year, the smallmouth bass limit was one over 21 inches. Beginning with the bass opener in late May, the limit will be six, with a protected slot of 17 to 20 inches (only one smallmouth bass can exceed 20 inches).
Similarly, a larger Mille Lacs northern pike harvest will be encouraged by a new 33- to 40-inch protected slot (with one fish allowed over 40 inches in a three-fish limit) — a big change from the 27- to 40-inch protected slot that regulated northern pike takings on the lake a year ago.
Thurmer believes the changes will do little to mitigate the effect on resort and bait shop owners, among other Mille Lacs area businesses.
Implicit in the new Mille Lacs walleye regulations are harvest projections the DNR developed based on past years' angling pressure and catch rates.
If the coming year proves to be an outlier to those estimates — if the walleye bite is either faster or slower than projected, for example — the DNR might have to alter its regulations, making them more liberal or still more restrictive.
A worst-case scenario, for example, would unfold if a hot walleye bite this summer puts too many 18-20-inch walleyes in anglers' boats, forcing the DNR to implement more restrictions to avoid exceeding the safe-harvest quota.
But even that move would be problematic, because the DNR includes an estimated 100,000 pounds of "post-release mortality" in the 178,500-pound sport-fishing quota.
Still, Suzy Fisher of Fisher's Resort near Isle remains hopeful.


Where the Heart Beats: John Cage biography by Kay Larson, reviewed.
John Cage meets D.T. Suzuki in Japan, 1962.
Courtesy of the John Cage Trust.
Quick word-association test: What do you think of when you hear the name John Cage?
But what else might there be in 4'33", and in John Cage himself? That question has, at some level, plagued many if not all of those who would write about the composer. In their efforts to be biographically comprehensive or else musicologically precise, there's been a certain hollowing-out of the basic fun involved in loving the very freeness of Cage's project, which at root sought to do away with all manner of rules—of harmony, of how music and dance could relate to one another, of the great-man theories that form our Germanically-Capitalized Notions of Genius in Fine Art.
While Gann solved this problem by going short, the art critic Kay Larson has now gone long—and speculatively gonzo—in her strangely structured, 417-page appreciation of the composer's public and inner lives, Where the Heart Beats: John Cage, Zen Buddhism and the Inner Life of Artists. The subtitle may seem to be casting about for an audience—a little bit for the self-help crowd, a bit for the art-history buffs—but this mashup of histories and aesthetics that Larson proposes develops into something not just convincing, but revelatory.
Larson knows from creative inner lives thanks to her multidecade career as an art critic for the likes of New York, ARTnews, the Village Voice, and the Times. Her Zen credentials originate, she tells us in a foreword, from an intensive study and practice of Buddhism that began in the wake of the "abrupt" end of her full-time job, back in the 1990s. (Media-world types might wince at the tale that bit implies.) Cage lover that I am, I entered the book dubious that she could unpack the work of Cage the composer, no matter how well read she is in his journals. I was nitpicking my way through the text, wondering why she was breaking up the Cage life-story to tell us about a centuries-old permutation of Buddhism even before the part of the story where Cage makes his own turn toward Zen. Was the book going to be this reductive and deterministic throughout, I wondered, by reading all of Cage's many permutations of mind as inexorably tied to his eventual Zen awakening? But after page 200—say, at the point when Larson brought Cage's first "happening" seamlessly into conversation with contemporaneous events like D.T. Suzuki's Columbia University lectures (which Cage attended) and the creation of "Mother of God" by Robert Rauschenberg (who had fallen into Cage's retinue)—I just started writing Wow in the book's margins. The whole strange mesh of it was speaking to me, and I stopped keeping score of how many times Larson missed or muffled a minor point—like her incorrect claim that CD players have always replaced turntables in modern performances of Cage's earliest percussion pieces. I merely began to treasure the odd texture of her finely synthesized enthusiasms, and what it could teach me about works I already thought I knew pretty damn well.
It sounds like a parody of a Buddhistically deep koan to suggest that the book about Cage most likely to entrance newcomers is the same one that will most startle the class of so-called experts on the subject—but that's the trick Larson has managed here. Some of the Cage-ian dramas that appeal mostly to modern-music geeks, like the composer's brief friendship and longer breakup with Pierre Boulez, are sketched briefly or not at all. His music for larger forces—such as choruses or orchestras—is given short shrift compared to small-ensemble pieces that engage dance and other forms (like conceptual art) more directly. Despite these choices, Where the Heart Beats may not just be the best book written yet about John Cage; it's probably also one of the most substantive-yet-readable entryways into the nexus of 20th-century American art and the immortal qualities of Eastern thought.
And if you do already have a copy of Credo, you'll pull it out again upon reading Larson's provocative suggestion, if only to marvel anew at how the piece's subtle layering of randomized sound samples works so elegantly with the written-out parts for piano and drums, despite having been fashioned on deadline for a fast-approaching dance recital. (Of course Cunningham fell for Cage. Of course he left Martha Graham's tutelage and conceptual approach behind. Wouldn't you do the same, if an admirer wrote something so perfectly tailored to your movements?) Just months after the premiere of Credo, Cage and Cunningham debuted a new collaborative piece, and the way Larson narrates the latter's contribution—"a short dance solo of leaps and half-turns of the spine and arms cocked at the elbow: movement without narrative content"—makes their coming together seem romantically and aesthetically inevitable.
Before his turn toward Zen, Cage's experimental spirit was inspired by what he saw in Cunningham's bearing—and to make that story sing, Larson has to tell the story of Cage's sexual evolution, and some truths about the law-weaponized forms of homophobia as practiced in the 1940s against other (allegedly) gay composers, more directly than other biographers have dared. (Cage and Cunningham maintained separate apartments until 1971, in what Larson chalks up to an abundance of caution.) But the leeway Larson gives herself always seems to earn out—her readings of Bergmanesque self-torment in Cage's Four Walls are persuasive, and fit sensibly enough in the composer's personal timeline, when he was growing apart from his wife and toward Cunningham. And this section also prepares readers for the more startling sections to come, in which, by reading her intuition alongside the known biographical facts, Larson allows herself to make broad, convincing arguments for Cage's magnetic power and pull over successive schools of artists.
And oh yes, by the way, basically every artist who mattered in the 20th century and who spent any time in America seems to make an appearance in this book: Duchamp, Pollock Warhol, Johns, Ono, and on and on—the gang's all here. Larson proves to be a talented gumshoe, turning up house records thought lost from the Artists' Club, started by New York's downtown crew of renegade painters in 1949. (She just knocked on some old doors). Late in the book Larson quickens her pace as she clarifies Cage's impact on successive generations of American artistic practice—Pop, Fluxus, the conceptual movements—as well as to individual artists like Alison Knowles and Bruce Nauman. These brief mentions could have sustained whole chapters.
Given that richness, who cares if Larson's book isn't grounded in dense music-theory knowledge? Other books have that territory covered, like Gann's Silence, James Pritchett's The Music of John Cage, and, the most biographically complete (if dry) work to date, Kenneth Silvermann's Begin Again, published last year. But Larson is after altogether different game, and playing by different rules. Cage was an unreliable enough narrator of his own life that he probably deserves at least one author willing to venture beyond the bounds of strict propriety in biography-writing.
It's 1949 or (most likely) 1950. We imagine Cage happily browsing in Orientalia, casually flipping open book covers, and being stopped in his tracks by the first page of [Suzuki's] First Series and its stunning first sentence … At this point, if I were Cage, I would buy the book and take it home.
The dangers here are evident. And yet, in part because Cage told different stories, over time, about this period in his life, there are things Larson (or any biographer) can't know. And at least Larson's methods are honest and transparent: Note how, when she can't decide in which year a scene she has fully imagined might have had its best chance to happen, she tells us that with some parenthetical vacillating! Because of the intentionality of her ruses, this empirically minded reader of nonfiction was able to suppress his "Hey you can't do that" reflex, similar to the one a serious concert-hall audience member might need to tamp down when told that everything happening on stage is being guided by a throw of Cage's I Ching coins. Like the composer himself, Larson gets enough results from her unlikely conceptual approaches to blow past the objections of the form police.
Tough-minded even when working at high levels of abstraction, Where the Heart Beats is one of the most profound, not to mention unexpected, gifts imaginable during John Cage's centenary year. Larson's is the first book about Cage to have the same feeling of listening to Cage—replete with the epiphanic moment of "ah," at which point the skeptical, hidebound mind may find itself pushing up against all the quotidian objections to unusual ways of organizing information, before breaking through to some other form of understanding—and a new definition of what may constitute the good life. There's something very calmly Zen about this, the way Where the Heart Beats doesn't feel the need to put down or else diminish our enjoyment of pop-culture jokes like "Cage Does Cage" while making its points. Instead, it feels as though Larson's book only hopes to exist alongside those tropes, while giving us a few additional words to use when talking about an artist who resisted the fixed implications of so many languages.
Where the Heart Beats: John Cage, Zen Buddhism and the Inner Life of Artists by Kay Larson. The Penguin Press.


Fremont Regional Hospice is selling Yankee Candles as a fundraiser to help patients who are uninsured or under insured. You can shop online at yankeecandlefundraising.com go to Start Shopping and enter Group # 999983496. It's not too late to order! Orders will be continued through the end of the year!


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Garbage Rate Changes Begin January 1, 2023
December 29, 2022 By City of West Chicago
The City's garbage and recycling pickup service provider, Groot Industries, Inc., will increase its service charges for residential solid waste collections as part of a contract with the waste hauler. The new service rates will be effective as of January 1, 2023.
Please see the following updated service fees:
Garbage Service Fee Per Month:
35-Gallon cart (Senior Rate): $9.84 (increase of $0.29)
35-Gallon cart (Regular Rate): $14.56 (increase of $0.42)
95-Gallon cart: $20.71 (increase of $0.61)
Additional Service Changes:
Universal Sticker: $2.51 (increase of $0.07)
Yard Waste Cart Annual Subscription: $218.55 (increase of $6.37)


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NIH gave millions to researchers accused of vax-development 'scam'
WASHINGTON – The National Institutes of Health sent around $17 million to a consortium of Colombian companies accused of developing a "questionable" malaria vaccine tested on owl monkeys held in squalor, The Post has exclusively learned.
People for the Ethical Treatment of Animals launched an investigation into the companies after a whistleblower passed along images of the disheveled primates used in NIH-funded experiments based on "shoddy science and manipulation of data," according to the animal rights group.
"It appears to be a huge scam, if I'm honest," PETA attorney Magnolia Martinez told The Post. "American taxpayers are being scammed into paying for a malaria vaccine that doesn't exist – and it will never be produced by using monkeys."
Socrates Herrera, who owns the companies with wife Myriam Arevalo-Hererra, denied the allegations in an email to the Post on Thursday, charging that PETA's claims are "based on false accusations and documents put out of context."
PETA launched an investigation after a whistleblower shared images of the disheveled primates used in NIH-funded experiments.
"Monkey studies have contributed to … successfully moving from the selection of malaria parasite antigens [in the discovery phase], to animal studies [in the preclinical phase], to human vaccine trials [in the clinical phase] with the support and supervision of institutions as prestigious as the World Health Organization," Herrera wrote.
But Martinez said her interviews with 11 former and current employees raised questions about the studies' integrity.
"They have published clinical trials where they supposedly have proof," she said. "However, based on the testimonies from insiders, we are not sure that they are actually doing what they're saying they're doing."
"It appears to be a huge scam, if I'm honest," PETA attorney Magnolia Martinez told The Post.
Herrera's companies – Caucaseco Scientific Research Center and the Malaria Vaccine and Drug Development Center and the FUCEP primate center in Cali, Colombia – have collaborative agreements with the NIH's National Institute of Allergy and Infectious Diseases, formerly headed by President Biden's chief medical adviser Dr. Anthony Fauci, but operate with little to no oversight.
While any US organization that uses animals for testing must be inspected annually and report any animal welfare violations to receive NIH funding, that rule does not apply overseas, Martinez said.
"They are being funded by American money, but they don't have to meet any of the American laws and no one cares," she said. "For fiscal year 2022, around 700 [NIH] grants were awarded to foreign institutions. Just imagine – we're talking about more than $200 million with no oversight at all. That's absurd."
Though US organization that uses animals for testing must be inspected annually and report any animal welfare violations to receive NIH funding, that rule does not apply overseas.
Now, PETA wants the NIH to enforce those same inspection and reporting requirements on foreign research labs. (NIH and NIAID did not respond to the Post's requests for comment).
Herrera said his companies would not oppose the rule changes – though he did not report animal welfare violations discovered by the Colombian government last year.
"We fully agree that the rules and regulations of NIH-funded projects must be similar, regardless of the site of research execution," he wrote. "… There should not be any undue burden to require self-reports on animal welfare violations or undergo an annual inspection of NIH-sponsored scientists."
Animal abuse accusations
An inspection last year by Corporación Autonoma Regional del Valle del Cauca, the regional environmental authority, found multiple animal welfare violations in the consortium's primate research center, FUCEP. At the time, the facility consisted of a chain-link fence with construction mesh used for walls and a roof, according to the official report.
Socrates Herrera, who owns the companies with wife Myriam Arevalo-Hererra, did not report animal welfare violations discovered by the Colombian government last year.
"There are no holes that allow the entry of UV rays and no windows that allow airflow," the inspector's report said. "The presence of food remains in the [water bowls], presence of high humidity in the enclosures [and] fungi demonstrate unsuitable sanitary conditions for the possession of primates."
The authority also found that there were "inappropriate densities" of groups of monkeys held in 2.6-foot cages, which were caked with feces and rust.
Herrera acknowledged the findings in an email to the Post on Thursday, claiming that the facility is now undergoing renovations to improve its "operation" and the inspection "was performed at the time the animal technicians were cleaning the facility."
The facility consisted of a chain-link fence with construction mesh used for walls and a roof, according to the official report.
"Based on a short visual inspection, [inspectors] concluded that there was animal abuse and malnutrition," he wrote. "These claims are based on superficial inspection without animal examination, animal-records analyses and laboratory tests."
The investigation also found that the facility did not keep medical records on the 127 owl monkeys and six squirrel monkeys at the facility. Further, no veterinarian was kept on staff, nor were there "endpoint protocol that determines the moment in which the animal must be withdrawn from the tests carried out."
Herrera denied those findings, claiming "we have always had vets at the center" — including two currently on staff.
"Over the 37 years that the primates center has been running, occasionally vets have been absent due to health leave, or vacation," he said. "Unfortunately the day that [the investigator] was visiting the facility, our vet was not present."
Investigators fowarded their report to the Colombian attorney general's office, which Herrera claimed then surveyed the facility and "concluded that there is no evidence of animal abuse or malnutrition."
"PETA has never approached us directly, and the Colombian government has not, on its own, opened any investigation besides those promoted by PETA based on anonymous and false information," Herrera added.
However, a prosecutor from the office on Dec. 2 sent Martinez, the PETA lawyer, an email stating the case was still under review but there was a "possibility" charges could be filed in the coming months of "crimes against life, the physical and emotional integrity of animals, as well as others."
Accusations of fraud
Martinez's investigation also uncovered disturbing allegations of false reports to the NIH and other agencies to keep funding flowing.
The investigation also found that the facility did not keep medical records on the 127 owl monkeys and six squirrel monkeys at the facility.
In two of Herrera's current NIAID grant applications, he stated that FUCEP and Caucaseco keep monkeys under the "care and welfare … [of] a veterinarian and trained technicians and are regulated according to the stipulations of the international guidelines" including the NIH's Guide for the Care and Use of Laboratory Animals – a claim that runs contrary to the November 2021 inspection.
Further, Martinez said she has obtained contracts from whistleblowers that suggest Herrera's employees were paid significantly less than those reported in grant applications.
For example, three employees "who allegedly performed activities related to NIAID grants" in 2015, 2017 and 2018 were paid monthly salaries of $582, $695 and $456, respectively, she said. However, Herrera in a 2020 NIAID grant claimed employees in similar positions would receive $2,166 to $2,541 per month.
No veterinarian was kept on staff, nor was there an "endpoint protocol that determines the moment in which the animal must be withdrawn from the tests carried out," according to the report.
"On at least one occasion, Herrera allegedly decided to end an agreement with [another] international funding agency when that agency asked him for proof that his employees were being appropriately paid with the resources provided by the agency to this end," Martinez said of a whistleblower's account.
When asked about the allegations, Herrera said he had "no figures" on salaries, but suggested some of the employees may not have had enough professional training to warrant the higher salaries requested in grant applications.
"In some opportunities we have not found the ideal person or training required for needs of the center, in which case the salary is lower than anticipates," he said. "In some cases you need more people with lower training and salary to accomplish a given task."
Martinez also said she has obtained contracts from whistleblowers that suggest Herrera's employees were paid significantly less than those reported in grant applications.
He added that the NIH allows principal researchers to "change the budget destination" of up to 25% of the allotted funds "without requesting any authorization."
"CSRC is proud of its institutional model and achievements in infrastructure and organizational development, scientific level and international leadership on sound scientific and administrative practices," Herrera wrote.
But PETA senior vice president Kathy Guillermo said the US government should take action against Herrera's consortium in light of the whistleblowers' accusations and other revelations from Martinez's investigation.
"NIH needs to cut off the money spigot to Caucaseco immediately and demand a return of all funds – and all scientific papers from this source and the MVDC should be immediately retracted," she said. "Congress should then suspend NIH's funds for foreign research organizations, since the agency is asleep at the wheel and can't be trusted."
Kardashian, Jenner New Year's Eve 2023 Celebrations: Photos
LPBW' Stars' New Year's Eve Celebration: Roloff Family Photos


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Thorpe Landscape Inc. we are a Full Service Landscape Company.
We will mow your lawn weekly or add a Patio for your enjoyment with friends and family creating a life time of memories. We have a Patio for every budget. Please call Dwayne anytime 703-926-6320 we are here for free advise even if you use our services or not.
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JOHANNESBURG (Reuters) – West Africa's regional BRVM bourse is targeting 12 new listings between 2018-2020, including one bank this year, the Abidjan-based exchange's chief executive said on Wednesday.
Edoh Kossi Amenounve also said he expected two listings this year by small to medium-sized enterprises (SMEs). He declined to name any of the firms that plan to list on the bourse.
"There is one in the main board in the banking sector and the two SMEs are in the distribution and IT sector," Amenounve told Reuters, referring to the listings for this year.
"We identified 10 SMEs in the region that can come to the market during the next 2 to 3 years," he added in an interview on the sidelines of an investor forum in Johannesburg.
The medium-sized companies have turnovers of more than $10 million, he added.
"We're in discussion with many of the private equity funds that are operating in our market and we think that some of them will exit during the next 3 years so we are working with them to have some of them list their investments on the BRVM," he said, without elaborating.
The regional bourse trades shares from 45 companies from some of the eight countries in the West African CFA franc currency union, including Senegal, Mali, Burkina Faso, Niger, Benin, Togo, and Ivory Coast, a statement by BRVM showed.


Composite "white" fillings were created as an alternative to traditional metal dental fillings. Composite fillings are strong, durable, and make for a very natural looking smile. They are called "white" fillings because of the natural, tooth color of the material. A composite filling is used when the cavity is small and you the patient desire a natural-looking restoration. Dr. Bae will numb the area, and then prepare the tooth for restoration, removing any decay. She will then apply the composite, and fill the cavity. After the composite has been cured, it will be smoothed and shaped for fit and comfort.
Following the placement of a composite filling, you may experience some discomfort or tenderness in the area. Complications from the use of composites are unlikely. It is possible that you may need an adjustment to accommodate your natural bite, and there may be minor sensitivity for a few days. Ibuprofen can be taken reduce the symptoms.


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Roy Fleischmann, MD: The Future of Biosimilars
Lana Dykes
Roy Fleischmann, MD, discusses the usage of biosimilars in the United States and hypothesizes about what is in store for the future.
In the final part of our biosimilars series, Roy Fleischmann, MD, discusses the usage of biosimilars in the United States and hypothesizes about what is in store for the future. Fleischmann is Clinical Professor of Medicine at the University of Texas Southwestern Medical Center at Dallas and co-Medical Director of the Metroplex Clinical Research Center in Dallas.
Rheumatology Network: Why do you believe the usage of biosimilars is not as popular within the United States when compared with other countries?
Roy Fleischmann, MD: If I have a patient, let's say treated with rheumatoid arthritis or psoriatic arthritis, and I started with methotrexate, and the patient doesn't have an adequate response, I want to use an innovative therapy. It could be a biosimilar or could be the biooriginal and, in my mind, both work the same. But many times, the experience has been that the pharmacy benefit manage has insisted on the biooriginal rather than the biosimilar primarily because of the rebate.
RN: How important are patient reported outcomes regarding the implementation of biosimilars?
RF: In terms of patient acceptance, it depends upon how the rheumatologist presents that to the patient. If I were told that a patient is on, for example, etanercept biooriginal, and I must change them to the biosimilar, and I tell the patient that the insurance company demands that I change them to the biosimilar, the patient may have the feeling that the biosimilar is not as potent, effective, or safe as the biooriginal. In most patients, maybe 95% of patients, it is. But because it's a forced switch of a drug that the patient has to do well on, there is a reluctance for many patients to switch.
Why change something that's not broken? If, however, the patient could take the biosimilar or the biooriginal and the access to the patient was better for the biosimilar, it was cheaper to the patient, then the conversation is I have 2 drugs. The biosimilars have been shown that it's generally almost always equal to the biooriginal, the safety seems to be the same, and the cost is cheaper. Why don't we switch for [their] benefit? Then the patient's reaction is different. The patient may still say, "I'm not going to change something's that broken," But many times the patients say, "Well, if it's the same, why not?" So, it's whether you're forced or not forced and how it was explained to the patient.
RN: What do you believe is in store for biosimilars in the United States?
RF: It depends upon what happens with our healthcare system. Right now, our healthcare system, while I still think is the best in the world, is broken. Were the rebate system to disappear, I think you'd see much more uptake of the biosimilar. If the insurance companies passed on savings, lower copays, that were more affordable to the patient, I think that they would be greatly used and there [would be] no reason why they shouldn't be used in that situation.
RN: What do rheumatologist need to know about the future of biosimilars in 2022 and beyond?
RF: I'm not sure it's 2022, but I think in 2024 biosimilars will be widely available. Many are approved, but, because of legal issues, they are not utilized (although some are). And I think that many more will be. Again, it depends upon patient access. If the patient access is better, there will be a much bigger uptake. If I can sell you a Ford or I can sell you a Bentley, and they both get you where you want to go, which is much more expensive than the other? Which would you buy? I would pick the Ford. If you told me that they were exactly the same, I'd [ask] which one's more comfortable? Which one has the better gas mileage? Am I still picking the Ford in that situation? It really does come down to economics. If there is no reason for a biosimilar unless it's cheaper, it should be substantially cheaper than the biooriginal.
Clinical NewsRheumatology


text:
Q: Change table column data to utf8 I have this column of table that contains data like :
Maintenant autorisé &agrav...Pour tout achat d&rsquo

I try to convert it so that text appear normally in french language, but i have failure. Behold how i try:
 $conn = mysqli_connect('localhost', 'root', '', 'sarldbcatw');
            mysqli_select_db($conn,'sarldbcatw')or die('Erreur de selection '.mysqli_error());

        $conn->set_charset("utf8");

            $slq = "SELECT * FROM MTbl_mazel_fiche order by Id_fiche";

            $req = mysqli_query($conn,$slq) or die('Erreur SQL !'.$sql.'
'.mysqli_error());

             while($data = mysqli_fetch_assoc($req))  {

        $fi_descript_fr_grd=htmlentities($data['fi_descript_fr_grd'], ENT_NOQUOTES, "UTF-8");
         $fi_descript_fr_grd = htmlspecialchars_decode($fi_descript_fr_grd);
                 $Id_fiche = $data['Id_fiche'];
                // echo $Id_fiche."

";
                 $sqlfic = "UPDATE MTbl_mazel_fiche SET fi_descript_fr_grd='$fi_descript_fr_grd'  WHERE  Id_fiche =".$Id_fiche;
                 mysqli_query($conn,$sqlfic) or die('Erreur SQL !'.$sqlfic.'
'.mysqli_error());

             }

Thanks so much.

redpajama_set_name: RedPajamaStackExchange


text:
import api from './api'
import { limit } from './index'

/**
 * 定义资讯对象
 * @typedef {Object} NewsObject
 * @property {number} id
 * @property {string} title
 * @property {string} subject
 * @property {string} author
 * @property {number} user_id
 * @property {*} more
 */

/**
 * 获取资讯列表
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {Object} params
 * @param {number} params.limit
 * @param {number} params.after
 * @param {string} params.key
 * @param {number} params.cate_id
 * @param {number} params.recomended
 * @returns {Promise<NewsObject[]>}
 */
export function getNewsList (params) {
  return api.get('/news', { params, validateStatus: s => s === 200 })
}

/**
 * 获取当前用户投稿列表
 * @Author   Wayne
 * @DateTime 2018-04-28
 * @Email    qiaobin@zhiyicx.com
 * @param {number}   type [类型: 0: 已发布, 1: 待审核, 2: 已驳回]
 * @returns {Promise<NewsObject[]>}
 */
export function getMyNews ({ type = 0, after = 0 }) {
  const params = { type, limit, after }
  return api.get('/user/news/contributes', {
    params,
    validateStatus: s => s === 200,
  })
}

/**
 * 根据 ID 获取资讯
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @returns {Promise<NewsObject>}
 */
export function getNewsById (newsId) {
  return api.get(`/news/${newsId}`, { validateStatus: s => s === 200 })
}

/**
 * 新增投稿
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} categoryId
 * @param {Object} params
 * @param {string} params.title 标题
 * @param {string} params.content 内容
 * @param {number|number[]} params.tags 标签id或其数组
 * @param {string=} params.subject 概要
 * @param {number=} params.image 缩略图
 * @param {string=} params.from 资讯来源
 * @param {string=} params.author 作者
 * @param {string=} params.text_content 纯文本
 * @returns {Promise}
 */
export function postNews (categoryId, params) {
  const url = `/news/categories/${categoryId}/currency-news`
  return api.post(url, params, { validateStatus: s => s === 201 })
}

/**
 * 搜索资讯
 * @author jsonleex <jsonlseex@163.com>
 * @param  {string} key
 * @param  {number} limit
 * @param  {number} after
 * @returns
 */
export function searchNewsByKey (key = '', limit = 15, after = 0) {
  if (!key) return Promise.resolve({ data: [] })
  const params = { key, limit, after }
  return api.get('/news', { params, validateStatus: s => s === 200 })
}

export function getNewsCommentPinneds (after = 0) {
  return api.get('/news/comments/pinneds', {
    limit,
    after,
  })
}

/**
 * 获取某资讯下的全部评论
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @param {Object} params
 * @param {number} params.after
 * @param {number} params.limit
 * @returns
 */
export function getNewsComments (newsId, params) {
  return api.get(`/news/${newsId}/comments`, {
    params,
    validateStatus: s => s === 200,
  })
}

/**
 * 评论一条资讯
 *
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @param {Object} payload
 * @param {string} payload.body
 * @param {number} [payload.reply_user=0]
 * @returns {Promise<{CommentObject}>}
 */
export function postNewsComment (newsId, payload) {
  const url = `/news/${newsId}/comments`
  return api
    .post(url, payload, { validateStatus: s => s === 201 })
    .then(({ data: { comment } }) => comment)
}

/**
 * 申请置顶
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @param {Object} data
 * @param {number} data.amount
 * @param {number} data.day
 * @returns
 */
export function applyTopNews (newsId, data) {
  return api.post(`/news/${newsId}/currency-pinneds`, data, {
    validateStatus: s => s === 201,
  })
}

/**
 * 申请评论置顶
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {Object} payload
 * @param {number} payload.newsId
 * @param {number} payload.commentId
 * @param {Object} data
 * @param {number} data.amount
 * @param {number} data.day
 * @returns
 */
export function applyTopNewsComment ({ newsId, commentId }, data) {
  const url = `/news/${newsId}/comments/${commentId}/currency-pinneds`
  return api.post(url, data, { validateStatus: s => s === 201 })
}

/**
 * 删除评论
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId 资讯 id
 * @param {number} commentId 评论 id
 * @returns {Promise}
 */
export function deleteNewsComment (newsId, commentId) {
  return api.delete(`/news/${newsId}/comments/${commentId}`, {
    validateStatus: s => s === 204,
  })
}

/**
 * 获取资讯点赞列表
 *
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @param {Object} params
 * @param {number} [params.limit]
 * @param {number} [params.after]
 * @returns {Promise<Object[]>}
 */
export function getNewsLikers (newsId, params) {
  const url = `/news/${newsId}/likes`
  return api.get(url, { params, validateStatus: s => s === 200 })
}

/**
 * 获取资讯打赏列表
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @param {Object} params
 * @param {number} [params.limit]
 * @param {number} [params.offset]
 * @param {string} [params.order] asc 正序 desc 倒序
 * @param {string} [params.order_type] date 按时间 amount 按金额
 * @returns
 */
export function getNewsRewards (newsId, params) {
  const url = `/news/${newsId}/rewards`
  return api.get(url, { params, validateStatus: s => s === 200 })
}

/**
 * 打赏资讯
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @param {Object} payload
 * @param {number} payload.amount 打赏金额
 * @returns
 */
export function rewardNews (newsId, payload) {
  const url = `/news/${newsId}/new-rewards`
  return api.post(url, payload, { validateStatus: s => s === 201 })
}

/**
 * 获得资讯统计
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @returns
 */
export function getRewardInfo (newsId) {
  const url = `/news/${newsId}/rewards/sum`
  return api.get(url, { validateStatus: s => s === 200 })
}

/**
 * 获取收藏资讯
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {Object} params
 * @param {number} params.limit
 * @param {number} params.after
 * @returns {Promise<NewsObject[]>}
 */
export function getCollectedNews (params) {
  const url = '/news/collections'
  return api.get(url, { params, validateStatus: s => s === 200 })
}

/**
 * 收藏资讯
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @returns
 */
export function collectionNews (newsId) {
  const url = `/news/${newsId}/collections`
  return api.post(url, { validateStatus: s => s === 201 })
}

/**
 * 取消收藏资讯
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @returns
 */
export function uncollectNews (newsId) {
  const url = `/news/${newsId}/collections`
  return api.delete(url, { validateStatus: s => s === 204 })
}

/**
 * 获取一条资讯的相关资讯
 *
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @param {Object} params
 * @param {number} [params.limit]
 * @returns
 */
export function getCorrelations (newsId, params) {
  const url = `/news/${newsId}/correlations`
  return api.get(url, { params, validateStatus: s => s === 200 })
}

/**
 * 举报动态
 *
 * @author mutoe <mutoe@foxmail.com>
 * @export
 * @param {number} newsId
 * @param {string} reason 举报理由
 * @returns
 */
export function reportNews (newsId, reason) {
  const url = `/news/${newsId}/reports`
  return api.post(url, { reason }, { validateStatus: s => s === 201 })
}

redpajama_set_name: RedPajamaGithub


text:
U.S.-China Cooperation: The Great Space Debate
By Leonard David 2006-04-12T13:22:00Z Spaceflight
Luo Ge (center), Vice Administrator of the China National Space Administration, dons a U.S. astronaut glove as he and his colleagues tour NASA's Goddard Space Flight Center in Greenbelt, Maryland earlier this month. Image Courtesy: GSFC/Christopher Gunn
China is stepping up itsspace program, preparing to launch dozens upon dozens of Earth orbitingsatellites over the next five to eight years. Also being readied are severalspace science missions, fielding a new heavy-lift booster, as well asstrengthening its human spaceflight program to include an Earth-circling spacelab and initiating a multi-step program of robotic lunar exploration.
Lastweek, Luo Ge, Vice Administrator of the China National Space Administration(CNSA), detailed his country's space aims in back-to-back addresses, first atthe Center for Strategic & International Studies (CSIS) in Washington, D.C. on April 3, followed by a presentation two days later at the National Space Symposiumin Colorado Springs, Colorado.
Inhis talks, Luo spotlighted China-Russia intergovernmental cooperation, aninter-governmental agreement with France and the European Space Agency, workwith Brazil on remote sensing satellites, and noted China's role in theConvention on Asia-Pacific Space Cooperation Organization.
NASAAdministrator, Michael Griffin, has confirmed that he has been invited to visit China, although no specific date has been set for the meeting.
Howbest to work with China is increasingly becoming part of a space policy debatein the United States. The posturing between nations is reminiscent of Cold Wardiscussions with the former Soviet Union. Those talks led to an array ofcooperative ventures, from weather data exchanges to the docking detente ofApollo-Soyuz in 1975, setting the stage for working together on theInternational Space Station project.
Defuse possible tensions
"China civil space plans are ambitious and inevitable," said Joseph Fuller, Jr., President and ChiefExecutive Officer of the Futron Corporation based in Bethesda, Maryland. "It is not a question of if, but when. For the U.S. exploration vision to succeedon a grand scale, it must include China, India, Russia and other space faringnations," he said.
"Substantialcollaboration already exists in business and economics," Fuller said, "why notcivil space?"
AsChina expands its automated and human spaceflight abilities, how best shouldthe United States look upon this blossoming work--from a military/civilianperspective? Denying NASA and U.S. space commercial vendors the right to work with China isa political, not a security issue, said James Clay Moltz, Deputy Director,Center for Nonproliferation Studies and Professor of International PolicyStudies at the Monterey Institute of International Studies in Monterey,California.
"Spacestation technologies are available from other suppliers and are unlikely tolead to any meaningful military advantages," Moltz explained. "On the otherhand, forcing China to develop its own space station with Russian or otherpartners simply sets up a possible competitor where there doesn't need to beone."
Moltztold SPACE.com that cooperating with China would defuse possible tensions,promote cost-savings for NASA, and level the playing field for U.S. companies. The United States should continue to hold China to account for human rightsviolations and other problems, but not hold space hostage. "It's simply not in U.S. interests," he said.
Elite club of countries
Givensuccess in the human spaceflight arena, Luo of CNSA said that his countryintends to orbit its own space lab by 2015. Leading up to this effort, headded, Chinese astronauts are to carry out space walks, with rendezvous andspace docking skills also to be demonstrated in coming years.
China carried out itsfirst human space voyage into Earth orbit in October 2003. That less-than-a-dayflight catapulted China into an elite club of countries that has this independentspace ability, following the former Soviet Union in 1961 and the United States in 1962. Last year, China sent a two-person crew into orbit on a five-daymission, substantially shaking out their Shenzhou spaceship.
Duringhis U.S. travels--including a stopover at NASA's Goddard Space Flight Center in Greenbelt, Maryland--Luo said his country will send a first robotic probe tothe Moon next year, make a soft-landing of a robotic rover on the Moon in 2012,and conduct an automated lunar sample return effort in 2017.
Therewas no direct mention by Luo of dispatching a crew to the Moon--or any timetable for such a feat--other than stating that he thought China will also consider the possibility of a manned mission to the Moon.
Lunar desires
"Ihappen to believe that their goal is to get to the Moon and that their scheduleis probably more ambitious than ours is," said former Congressman Robert Walkerand now chairman of Wexler & Walker Public Policy Associates in Washington, D.C.
Walker also chaired theCommission on the Future of the United States Aerospace Industry and was amember of the Presidential Commission on the Implementation of the UnitedStates Space Exploration Policy.
China's lunar desires will be seen bysome people as a very direct challenge, Walker said, "but for the Chinese itwill simply establish respect for their science and technology programs, whichwill then allow them, perhaps, to command a bigger price for a lot of theirproducts in the world market."
Walker told SPACE.comthat China's growing space prowess is "a very strategic kind of concept forthem," adding: "If we are going to be competitive in a world environment weneed to respect and do our job of anticipating and responding."
More assurances needed
Interms of working with China on space matters, Walker said there is need for"more assurances" than the U.S. presently has about the Chinese willingness torespect technology, copyrights and patents.
"Wehave challenges with the Chinese at the present time because the rule of lawsometimes means different things to them than it means to us," Walker added. "We're trying to work that out through World Trade Organization arrangementsand hopefully some day we will."
Walker said thatU.S.-China space cooperation should be very carefully measured. There is needto assure that the United States, he said, doesn't end up giving Chinatechnology that challenges, and possibly exceeds, American space expertise.
Leadershipin space technology is a very important part of the United States beingcompetitive in the 21st century, Walker said. "We do not want to easily give upthe technology that allows us to stay in the lead."
MostAmericans think that the United States is so far ahead in the space arena thatno one will ever catch us, Walker concluded. "In my view, that's a mistake tobelieve that...because there are people with ambitions that rival our own."
A capitalist,poverty-elimination machine
InJanuary, China permitted several U.S. lawmakers to visit the Jiuquan Satellite Launch Center, an expansive complex that dots the desolate desert of Gansu Province. In 1970, China's first satellite rocketed into Earth orbit from thislocation. It is also home base for its budding human spaceflight program.
Onthat first-of-its kind trip, three U.S. Congressmen, Rep. Mark Kirk, R-Ill,Rep. Rick Larsen, D-Wash., and Rep. Tom Feeney, R-Florida made the fact-findingjourney as members of the U.S. Congress' China Working Group.
Purposeof the group, Feeney told SPACE.com, is to help disconnect a lot ofthinking in the U.S. House of Representatives from dated Cold War perspectives.Specifically, that today's China is equivalent of the Soviet Union 40 years ago-a perspective that is "just not true," he said.
"Inlarge parts of their country, the Chinese are a capitalist, poverty-eliminationmachine," Feeney observed. True, they have a long way to go on property rightsand civil rights, and other issues, he said, but the China of today is "aunique situation" among nations around the globe.
TheChina Working Group wants to look at China as it is today, based on real facts,not--as some people are incorrectly thinking--based on a Cold War vision, Feeneysaid.
Dramatic rethinking
Invisiting the Jiuquan Satellite Launch Center, Feeney said he was struck by boththe remoteness of the locale, as well as how modern their multi-floor rocket vehicleassembly facility was--taking on the appearance of a suburban office building.
Feeneyreiterated what other U.S. analysts have expressed. "In the United States, we're training our American aerospace engineers how to maintain 20 to 40year-old technology. The Chinese are literally developing new technology ontheir own."
Interms of the United States linking-up with China's space program in pursuingcooperative causes, Feeney advised: "There is a dramatic rethinking in thespace community and within NASA about the advantages of working with China."
Legitimate concerns
Someten to fifteen years ago, China brought no added value to the space cooperationtable, Feeney said. But in very short order that has changed, with China making a commitment to space and now have proven capability that demonstrates theirtechnological wherewithal.
"Themost immediate thing we ought to agree to in my view is a joint dockingdevice," Feeney pointed out. Having the ability to dock NASA's Crew ExplorationVehicle (CEV) to a future Chinese space station should be considered. So too ishaving a Shenzhou spacecraft capable of attaching to a stranded CEV if need be,he added.
Butputting such ideas aside, Feeney said there remains a "big caveat in all ofthis." There are "very legitimate concerns" raised by the U.S. military, he said, about the ultimate intention of the Chinese.
Withnewly announced defense budget increases in China, the defense community findsit difficult to talk about sharing technology or capabilities between the twonations, Feeney explained. Furthermore, China's building of a new launchfacility to handle heavy-lift rocket operations is worrisome to U.S. space defense officials.
Take home messages
Whilethe heavy-lift Long March booster is key for building a space station, to honenear-Earth and lunar exploration operations, Feeney said the launcher's throwweight can seed space with killer satellites that could "incapacitate America'sspace communications and space predominance."
"Soas we talk about cooperation, we have to think about the really big issues,"Feeney noted. "It's one thing to talk about human spaceflight ... rescue ofastronauts ... other types of technology generates this concern."
Askedwhat his take home messages were after viewing, in person, China's space program, Feeney said: "The Chinese have a long way to go to catch us in spacecapabilities. But they are very focused ... they have had huge success ... and theyare very dedicated to being a space leader."
NASA Chief Michael Griffin Invited to China
China Unveils Ambitious Space Plans at National Space Symposium
Special Report: Emerging China, Engaging China