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Vol 9, No 6 (December 2020) /
Changes in the levels of T lymphocytes and inflammatory factors in the peripheral blood of breast cancer patients...
Changes in the levels of T lymphocytes and inflammatory factors in the peripheral blood of breast cancer patients during postoperative chemotherapy
Cunliang Wang1,2, Wei Han3, Yuanting Gu1
1Department of Breast Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; 2Medical Service, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; 3Quality Control Division, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Contributions: (I) Conception and design: C Wang, Y Gu; (II) Administrative support: W Han; (III) Provision of study materials or patients: C Wang, W Han; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: C Wang, Y Gu; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.
Correspondence to: Yuanting Gu. Department of Breast Surgery, the First Affiliated Hospital of Zhengzhou University, 1st Jianshe Dong Lu, Zhengzhou 450052, China. Email: zdyfysci@163.com.
Background: As one of the main malignant tumors affecting women, the incidence of breast cancer increases year by year. This study aims to analyze the risk factors of infection in breast cancer patients during postoperative chemotherapy by measuring the changes in the levels of T lymphocytes and inflammatory factors in peripheral blood.
Methods: The clinical data of 156 patients who underwent radical mastectomy and postoperative chemotherapy [docetaxel, epirubicin, cyclophosphamide (TEC)] in our hospital from May 2014 to April 2018 were retrospectively analyzed. According to the presence or absence of infection after chemotherapy, patients were divided into the infection group and the normal group. The risk factors of infection during chemotherapy were analyzed by univariate and multiple logistic regression analyses. Serum before surgery, and before and after chemotherapy, was collected to detect the levels of T lymphocytes and inflammatory factors.
Results: A total of 36 patients developed an infection during chemotherapy, with an infection rate of 23.08%. The main infection site was the respiratory tract. The main pathogens detected were Gram-negative bacteria and Gram-positive bacteria. The results of univariate analysis showed that there were significant differences in age, diabetes mellitus, clinical TNM staging, white blood cell count (WBC), T lymphocyte subsets CD4+/CD8+, C-reactive protein (CRP) levels, and tumor necrosis factor-α (TNF-α) levels between the 2 groups (P<0.05). Results of logistic regression analysis showed that age ≥60 years old, diabetes mellitus, clinical TNM staging ≥ stage III, WBC <3.5×109/L, CD4+/CD8+ <1.33, TNF-α ≥70 ng/L and CRP ≥60 mg/L were all independent risk factors of postoperative infection (P<0.05). Both before and after chemotherapy, levels of CD3+, CD3+CD4+ and CD4+/CD8+ cells in the infection group were significantly lower than those in the normal group, while levels of CRP, TNF-α and IL-6 were significantly higher than those in the normal group (P<0.05).
Conclusions: Dynamic monitoring of changes in the levels of T lymphocytes and inflammatory factors during chemotherapy may be of clinical value for predicting the risk of infection. Implementing targeted intervention measures for these risk factors may therefore be beneficial for controlling infection.
Keywords: Breast cancer; radical surgery; chemotherapy; infection
Submitted Oct 18, 2020. Accepted for publication Dec 08, 2020.
Breast cancer is one of the main malignant tumors that poses a significant threat to women's health, with an increasing incidence year by year (1). In the treatment of breast cancer, more than 5% of patients present with distant metastasis at the time of first clinical diagnosis, and 50% of patients will still undergo relapse and metastasis after treatment (2,3). At present, adjuvant chemotherapy after radical mastectomy is the main treatment approach for breast cancer, which can not only improve the long-term survival rate of patients, but also reduce the chance of recurrence. However, patients with breast cancer are in an immunosuppressive state. Radical mastectomy is a kind of treatment with surface wound, and larger surgical procedures will suppress the immune system. Additionally, chemotherapy drugs can often cause varying degrees of damage to the body's immune cells. Therefore, patients with breast cancer are prone to infection during chemotherapy after radical surgery, which is not conducive to the treatment and prognosis of the disease (4).
As the most important and complex cells of the adaptive immune system, T lymphocytes participate in processes such as tumor immune surveillance, tumor cell killing and immune regulation. According to the different cluster of differentiation (CD) phenotypes, T lymphocytes can be divided into CD4+ (helper T cells) and CD8+ (cytotoxic T cells). Under healthy conditions, the ratio of CD4+ and CD8+ is in a relatively balanced state to maintain the stability of immune function, hence the CD4+/CD8+ ratio is often used to reflect the body's immune function (5). During an inflammatory response, especially with bacterial infections, factors such as interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) increase. Therefore, the levels of these inflammatory factors can reflect the infection status of the body to a certain extent (6).
In this study, we analyzed the clinical data of 156 breast cancer patients to explore the risk factors for infection during chemotherapy, along with changes in peripheral blood T lymphocytes and inflammatory factor levels. We therefore propose targeted intervention measures for infection in breast cancer patients during postoperative chemotherapy. We present the following article in accordance with the STROBE reporting checklist (available at http://dx.doi.org/10.21037/gs-20-818).
The clinical data of 156 breast cancer patients who underwent chemotherapy in our hospital from May 2014 to April 2018 were retrospectively analyzed. All patients met the diagnostic criteria for breast cancer (7) and underwent radical mastectomy, and received adjuvant treatment with postoperative chemotherapy. The exclusion criteria were as follows: (I) patients with preoperative or pre-chemotherapy infection; (II) patients with severe heart, liver, or kidney dysfunction; (III) patients who had recently taken immunosuppressive agents or immunomodulators; (IV) patients with acute local inflammation or systemic inflammation. All patients were female, aged 41 to 69 years, with an average age of 52.6±9.1 years. There were 105 cases of invasive ductal carcinoma, 27 cases of invasive lobular carcinoma, and 24 cases of mixed cancer, and 19 cases were at TNM stage I, 121 were at stage II, and the remaining 16 cases were at stage III. As for the complications, there were 21 cases with diabetes, 35 cases with hypertension, and 82 cases with cardiovascular disease. All procedures performed in this study involving human participants were in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by the First Affiliated Hospital of Zhengzhou University (NO.: 2020-KY-0119). Individual consent for this retrospective analysis was waived.
According to their status, patients were treated with modified radical mastectomy, breast-conserving radical mastectomy, or simple breast resection + sentinel lymph biopsy. A docetaxel + epirubicin + cyclophosphamide (TEC) chemotherapy regimen was administered after surgery. Chemotherapy was performed for 6 cycles, with 21 days for each cycle, and each time lasted for 1 day. During chemotherapy, saliva and blood were collected for cell testing, and the "Diagnostic Standards for Nosocomial Infection" (8) formulated by the Ministry of Health was used to determine whether or not the patient had an infection.
Observation indicators
Fasting venous blood (3 mL) was collected in EDTA anticoagulation tubes from all patients before surgery, as well as before and after chemotherapy. The blood was refrigerated at 4 °C for inspection without coagulation or hemolysis. The lymphocyte subset detection kit (BD Company, USA) and MultiSET software were used to detect and analyze the levels of CD3+, CD3+CD4+, CD3+CD8+, CD4+/CD8+ cells in peripheral blood. The levels of IL-6, CRP, and TNF-α in peripheral blood were detected using enzyme-linked immunosorbent assay (ELISA), with all the ELISA kits provided by Beijing Lvyuan Bird Biotechnology Company (Beijing, China).
All data was analyzed using SPSS 17.0 software (IBM, USA). Count data was expressed as rate and analyzed using a chi-square (χ2) test. Measurement data conforming to the normal distribution was expressed as the mean ± standard deviation, and analyzed using a t-test for comparisons between 2 groups. The multivariate analysis was performed by stepwise multiple logistic regression analysis. Results with P<0.05 were considered to be statistically significant.
Infection status of the patients
Among the 156 patients, 36 patients developed an infection during chemotherapy, with an infection rate of 23.08%. The main infection sites were the oral cavity and the respiratory tract, accounting for 47.22% (17/36) and 33.33% (12/36) of cases, respectively. A total of 42 strains of pathogenic bacteria were detected, and Gram-negative bacteria and Gram-positive bacteria were the main pathogens detected, accounting for 47.62% (20/42) and 33.33% (14/42) of cases, respectively.
Univariate analysis of infection in breast cancer patients during postoperative chemotherapy
The results of the univariate analysis showed that there were significant differences between the 2 groups in factors such as age, combined with diabetes, clinical TNM stage, white blood cell count (WBC), T lymphocyte subsets CD4+/CD8+, TNF-α, and CRP (P<0.05, Table 1).
Table 1 Univariate analysis of infection in breast cancer patients during postoperative chemotherapy
Multiple logistic regression analysis of infection during postoperative chemotherapy in breast cancer patients
The postoperative infection outcome was used as the dependent variable (setting 0 for normal, and 1 for infection), and risk factors including age (<60 years old assigned as 0, ≥60 years old as 1), combined with diabetes (not combined as 0, combined as 1), TNM staging (stage I or II assigned as 0, stage III as 1), WBC (≥3.5×109/L assigned as 0, <3.5×109/L as 1), CD4+/CD8+ (≥1.33 assigned as 0, <1.33 as 1), TNF-α (<70 ng/L assigned as 0, ≥70 ng/L as 1), and CRP (<60 mg/L assigned as 0, ≥60 mg/L as 1) were used as independent variables. Multiple logistic stepwise regression analysis was then performed, and the results showed that age ≥60 years old, combined with diabetes, clinical TNM staging ≥ stage III, use of triple antibiotics, WBC <3.5×109/L, CD4+/CD8+ <1.33, TNF-α ≥70 ng/L, and CRP ≥60 mg/L were independent risk factors for postoperative infection in breast cancer patients (P<0.05, Table 2).
Table 2 Multiple logistic regression analysis of infection in breast cancer patients during postoperative chemotherapy
Comparison of serum T lymphocytes before and after chemotherapy in the 2 groups
The levels of CD3+, CD3+CD4+, and CD4+/CD8+ cells in the infection group before and after chemotherapy were significantly lower compared to the normal group (P<0.05), while the level of CD3+CD8+ cells was not statistically different from the normal group (P>0.05, Table 3).
Table 3 Comparison of serum T lymphocyte levels before and after chemotherapy between the 2 groups
Comparison of serum inflammatory factor levels before and after chemotherapy in the 2 groups
Results showed that the levels of CRP, TNF-α, and IL-6 in patients in the infection group before and after chemotherapy were significantly higher than the normal group (P<0.05, Table 4).
Table 4 Comparison of serum inflammatory factor levels before and after chemotherapy between the 2 groups
Lymphatic vessel obstruction, tumor cell invasion, and damage to the body's anatomical barriers during radical mastectomy are all causes of reduced immunity in breast cancer patients. In order to improve the survival rate of patients and reduce the recurrence rate after surgery, adjuvant chemotherapy is usually administered to stabilize the disease. However, most chemotherapeutic drugs will inhibit granulocyte production to varying degrees, further reducing immunity. Hence, breast cancer patients undergoing chemotherapy are at a high-risk of nosocomial infections (9,10). In this study, there were 36 cases among the total of 156 breast cancer patients who developed infections during chemotherapy, and the respiratory tract was the main infection site. The use of chemotherapy drugs and immunosuppressive agents decrease the levels of globulin IgA in the airway mucosa. Thus, respiratory ciliary clearance mechanisms and local immune screens are reduced, and pathogens are more likely to invade the respiratory tract and cause infection in the airway mucosa (11). Furthermore, the hospital is a special place with a much higher probability of pathogenic bacteria than that of other places, and from the detection of pathogenic bacteria in infected patients, the results indicated that most of the pathogens are multi-conditional pathogens. It can be seen that infection is mostly endogenous, and that in addition to the decrease in immunity, the application of a large number of antibiotics and hormones will also cause an imbalance of bacteria in the body and increase the risk of infection (12).
In this study, the results of the univariate analysis and the multivariate logistic regression analysis found that factors such as age ≥60 years old, diabetes, clinical TNM staging ≥ stage III, WBC <3.5×109/L, CD4+/CD8+ <1.33, TNF-α ≥70 ng/L and CRP ≥60 mg/L were all independent risk factors for postoperative infection. With increasing age, the body's functioning gradually declines, especially the immune system. Studies have shown that the level of CD8+ cells decreased in the peripheral blood of breast cancer patients aged >55 years, while the level of B cells increased, suggesting that it is necessary to pay more attention to the immune function of elderly patients during the processes of clinical diagnosis and treatment. During treatment, the use of immunosuppressive drugs should be reduced and immunotherapy should be strengthened (13). Incision infection is more likely to occur in patients with diabetes, as the immunity of patients with diabetes is often impaired. Furthermore, the environment of high blood sugar in diabetic patients provides suitable growth conditions for pathogenic bacteria, and incision in diabetic patients is not easy to heal after surgery (14). As for the influence of TNM stage, the higher the clinical TNM stage, the higher the degree of tumor invasion and metastasis to the lymph nodes, which may cause lymphatic blockage, impair immunity, and increase the risk of infection. Previous studies have shown that the infection rates of patients with WBC ≤1×109/L, 1×109–4×109/L, and 4×109–10×109/L are 22.11%, 18.52%, and 8.24%, respectively (15), indicating that the lower the WBCs, the higher the probability of infection. In this study, we found that the level of WBCs in the peripheral blood of patients with an infection during chemotherapy was significantly lower than that of patients without an infection, further confirming that a decrease of WBCs is a risk factor for infection in breast cancer patients during treatment with chemotherapy. Immunity is often determined by different subgroups of T lymphocytes. The ratio of CD4+/CD8+ cells is an important indicator reflecting the balance of T lymphocyte subgroups, and remains constant between 1.5 and 2.0 in the healthy body. However, the ratio of CD4+/CD8+ cells in breast cancer patients is seriously imbalanced, causing impaired immune function, thereby increasing the likelihood of invasion by pathogenic bacteria (16). TNF-α is a type of pro-inflammatory cytokine secreted by Th1 cells, and high levels of TNF-α are conducive to tumor growth. When pathogenic bacteria invade, TNF-α levels increase, therefore high levels of TNF-α may be a biological indicator of the occurrence of infection (17). CRP is a protein that is indicative of an inflammatory response, and can increase rapidly when the body is injured or undergoes certain inflammatory changes (18). Studies have shown that increased levels of CPR can be detected before the occurrence of clinical symptoms of infection in patients, so a high level of CRP in patients can indicate that the patient has an infection (19). In view of the risk factors mentioned above for infection in breast cancer patients during postoperative chemotherapy, corresponding intervention strategies can be adopted to reduce infection rates as follows: (I) for elderly or immunocompromised patients, nutritional support and immune-enhancing drugs are required during chemotherapy. At the same time, for basic diseases such as diabetes, blood sugar levels should be controlled as much as possible, and the length of hospitalization should be reduced as much as possible to decrease the chance of contact with pathogenic bacteria; (II) aseptic operation procedures in the treatment and nursing process should be strengthened, and antibiotics need to be used in a reasonable and appropriate amount strictly according to the chemotherapy regimen and the results of drug sensitivity tests; (III) close attention should be paid to the blood biochemical indicators of the patients. As chemotherapy causes the suppression of bone marrow, patients with WBC <1×109/L should be treated with a lower dose of pharmaceutical drugs. In this study, by measuring T lymphocytes and inflammatory factors in patients before and after chemotherapy, results showed that the levels of CD3+, CD3+CD4+ cells, and the ratio of CD4+/CD8+ cells in the peripheral blood of patients in the infection group were significantly lower than those in the normal group both before and after chemotherapy, suggesting that low immunity before chemotherapy will increase the risk of infection, and the occurrence of infection will further suppress the body's immune response. At the same time, this study also found that serum CRP, TNF-α, and IL-6 levels in patients in the infection group before and after chemotherapy were significantly higher than those in the normal group, indicating that high levels of inflammatory factors may have a certain predictive value for infection during chemotherapy.
In summary, breast cancer patients have low immunity during adjuvant chemotherapy after surgery, making them a high-risk group for infection. Dynamic monitoring of changes in T lymphocytes and levels of inflammatory factors may have clinical value for predicting infection during chemotherapy after surgery. This may also help to reduce and control infections by developing and implementing targeted intervention measures for the risk factors of infection.
Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All procedures performed in this study involving human participants were in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by the First Affiliated Hospital of Zhengzhou University (NO.: 2020-KY-0119). Individual consent for this retrospective analysis was waived.
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(English Language Editor: C. Betlazar-Maseh)
Cite this article as: Wang C, Han W, Gu Y. Changes in the levels of T lymphocytes and inflammatory factors in the peripheral blood of breast cancer patients during postoperative chemotherapy. Gland Surg 2020;9(6):2155-2161. doi: 10.21037/gs-20-818
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Q: Prime counting formula considered by S.Wigert Consider the following integral:
$$π(n)=\frac{1}{(2πi)}\oint_{C_n}\frac{f'(x)}{f(x)}dx$$
Where ,
$$f(x)=\sin^2(πx)+\sin^2(π(1+\Gamma(x))/x)$$
The integral extends over a closed contour $C_n$ enclosing a segment  $x$- axis from $1$ to $n$
and narrow enough to contain no complex zero.
We can clearly see that $f(x)$ has real zeroes only at primes .
This integral is considered by S.Wigert.

Question: Is this analysis "resurrectable"? By resurrectable I mean can this be modified such that it may be workable?

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Home » india » 'Rahul is trying to play a communal game'
April 16, 2019 india
'They thought he can separate the Muslim votes and win, but the Kerala mind is completely different.'
'It is a secular mind because Hindus, Christians and Muslims live together.'
'We don't like somebody coming from outside, contesting in our state, winning and going and avoiding us.'
Even in tiny Kalpetta, the district headquarters of Wayanad that sits at the tri junction of Kerala, Karnataka and Tamil Nadu, it is not easy to find the guest house Thushar Vellapally is camping at.
Vellapally, a businessman and president of the Bharath Dharma Jana Sena, an ally of the Bharatiya Janata Party in Kerala — was brought in from the Thrissur Lok Sabha seat to contest against Rahul Gandhi by BJP President Amit Anilchandra Shah, whom Thushar refers to as Amitbhai.
The guest house is a bungalow in the midst of an abundantly green garden; the car that will take him campaigning for the day is ready in the driveway.
In the sitting room, the sofas are occupied by family and friends — one among them is Thushar's wife Asha.
A soft spoken and pleasant lady dressed in a kurta and parallel pants, she comes out to say hello — today is the first day she will go out campaigning with women to muster support for her husband.
The BDJS is a political party associated with the Sree Narayana Dharma Paripalanayogam, SNDP, an organisation for the prominent Hindu Ezhava community in Kerala.
The party was formed in 2016 and contested 37 seats in the assembly election.
The BJP-BDJS alliance won one seat (BJP veteran and former Union minister O Rajagopal was elected an MLA from Thiruvanathapuram) and accounted for nearly 15% of the vote share.
This is Tushar Vellapally's first Lok Sabha election and he has launched an aggressive campaign to take on Rahul Gandhi.
Wayanad is dotted with posters of all three major contestants, and Vellapally had undertaken a road show through Sulthan Bathery — another town in Wayanad — the previous evening.
Just before setting out for the day's campaign, the candidate spoke to Rediff.com's Archana Masih under a shady tree, ahead of a very hot day in Wayanad.
When did you exactly know that you were to contest from this seat? When did Amit Shah tell you about your candidature?
When discussion started about this seat and it was known that Rahul Gandhi was going to contest, Mr Shah told me to contest.
I said whatever the PM and Amitbhai say, I will do.
I had started work in Thrissur and had already campaigned for 5 days there.
It was during that time that they declared Rahul Gandhi's candidature and Amitbhai called me and said can you contest. I said if you wish, I will.
How do you describe your relationship with Mr Shah? How has it been built?
I am a party leader and we had a connection for 2, 3 years.
You said you left Thrissur to come to Wayanad. What if you lose? Is it the price to pay for a better relationship with the BJP in the future?
This is my party's seat and the NDA needed a strong candidate in Wayanad.
That's why Amitbhai and the PM told me to come here and I came.
What do you think of Rahul Gandhi? Who is your opponent in this election? Rahul or the LDF's P P Suneer?
Rahul is my opponent.
He can't pull a good performance here because Malayalis are different.
They are educated people.
Rahul is trying to play a communal game here.
They thought he can separate the Muslim votes and win, but the Kerala mind is completely different.
It is a secular mind because Hindus, Christians and Muslims live together.
We don't like somebody coming from outside, contesting in our state, winning and going and avoiding us.
Especially, Wayanad is a different place with different people.
Nearly 40% are tribes and they can't even interact with Rahul Gandhi.
Video Editor: Rajesh Karkera/Rediff.com
You are accusing Rahul Gandhi of running a communal campaign?
He is running a communal campaign and only trying to get minority votes.
His family separated India and Pakistan, similarly he is talking about south India and north India.
Why does he want to talk like that? By coming from north India to contest in south India, is he going to rescue people from all their problems?
The party that you are aligned with — the BJP — is perceived to be communal, so isn't this a dichotomy? You say you are secular, but the party you are aligned is thought to be otherwise.
How can you talk like that? The BJP is not a communal party.
For 55 years, the Congress was ruling and every year communal riots were happening in India, but in the last 5 years there have been no communal riots.
How can you call the BJP communal? The BJP has aligned with Muslims; in Goa with Christians.
In the north, the BJP aims to consolidate the Hindu vote like in 2014.
That is a different angle.
Different people have different angles. That is it.
Why is your party so important to the BJP? Is it because of the numerical strength of the Ezhava community?
This party is not only for the Ezhava community.
Our vice president is a Christian priest.
There are Muslims, Hindus in the party.
You see nothing wrong in aligning with the BJP?
What is the problem? The BJP is a secular party.
It is not a communal party.
There is no problem when the Congress aligns with the Muslims League and Kerala Congress.
Do you think the BJP is more secular that the Congress?
100%. The BJP always stands for the Muslims, Christians and Hindus.
Your father told my colleague Shobha Warrier that the 'BJP does not have political decency'. Soon after, to assuage his anger, the BJP made you convenor of the NDA in Kerala.
No, never, never. I was proposed by Amitbhai when the NDA started and I became convenor.
He (SNDP general secretary Vellapally Natesan) did not give any negative statement about the central government.
He spoke about the system not being good in the state of Kerala.
He did not talk about Amitbhai or the prime minister.
Has the relationship between your party and the state BJP unit improved?
It has. Earlier, the NDA wasn't formed and its work wasn't happening.
Now the NDA is very strong in Kerala.
Are you sure of 100% support from the local BJP for your candidature?
100%. Three more (BDJS) candidates are contesting in this election and everywhere the BJP is supporting us.
Is the BJP or your party running the everyday schedule of your campaign?
All the programmes are fixed by the NDA committee.
Are the Ezhavas moving away from the Left to your party?
Yes. A lot have moved away.
I was also an SFI (the Communist of India-Marxist's Student Federation of India) chairman.
They (Ezhavas) have shifted (from the Left) because they are not doing anything for the development of Kerala.
The LDF and UDF have ruled Kerala after Independence and look at the infrastructure. The government offices are either built by the British or the Rajas.
The development here is done by the people who went to the Gulf, made money and built houses here.
How big a factor is Mr Modi in this election in Kerala?
He is a big factor.
Kerala is looking for development and for that Modi is big.
You are new to the people here and they are new to you — what has been your interaction like?
I am not new here.
I am connected to the people because I am a Malayali.
We are not accepting anybody from outside (laughs).
How can Rahul Gandhi connect with Kerala and the people of Wayanad?
Your father told us once that he wants to unite the Hindus of Kerala.
Do you think that dream is an impossibility given the fact that there are such divisions between the upper castes and backward castes like the Ezhavas?
That is not a big problem because even now everyone is trying to unite them.
All Hindus have to have strength because all sections of Hindus have to be together.
We are doing it and that is almost done.
When is your party likely to merge with the BJP?
We are not. We are a separate political party (laughs).
If I wanted to merge with the BJP, I could have done it before.
What quality of Amit Shah impresses you most?
Amitbhai and the PM have done lots for India and we respect that.
How often do you talk to him?
Every month, twice or thrice.
What are his concerns? What do you talk about?
We only talk about one thing — terrorism.
We are against terrorism.
All of India has to be together and we have to develop India, that is our aim and that is his dream.
You spoke about terrorism. What do you think about the fact that some Malayalis, especially from Malabar, have joined ISIS?
It is a very bad situation.
We know a lot of things are happening.
The reason is poverty.
Nobody wants to become a terrorist or Maoist.
They become anti-social elements because they don't have money and jobs.
BJP leader V Muraleedharan once told us that Kerala will become another Kashmir.
I don't think so because a majority of Muslims, Christians, Hindus want Kerala as a secular place.
A very small minority — 10, 15 — are going for ISIS because nobody supports them.
Even their families are not supporting them.
What is your slogan?
Development. Wayanad is a backward district in Kerala.
There are no major hospitals here.
What are your impressions about Mr Modi?
He is great and very nice.
I have met him a lot.
What are the principles that drive your politics?
Development. For 55 years the Congress ruled India and what have they done? They only started all the communal problems.
The separation between Hindus, Muslims, Christians have been made by the Congress.
Twenty years ago, we did not know who is Muslim, who is Christians, who is Hindu.
In the last 20, 25 years, they have created political parties in the name of communities and support any consolidated community.
That's how communal thinking has started even in Kerala.
You are a businessman, what led you to politics?
I was the SNDP's vice president and youth movement president for 20 years.
We are connected with politics.
Our community realised that the LDF and UDF was not supporting us and we started a new political party to fight against them.
In the three years that your party has been in existence, what are your achievements?
Three years back we started the party and strengthened it.
If you take the four political parties of Kerala, we are one of them.
Do you think the BJP wants to grow in Kerala by concentrating on the Ezhavas?
Don't talk only of the Ezhavas.
In the last election, we won one seat and came 2nd in seven seats.
Before that, our vote share was only 6% — the last (assembly) election our vote share was 17%.
If you take Maharashtra, UP, Goa, what was the BJP's vote share before? 12%, 9%, 8%. Compared to that, our jump is bigger.
What is your party's contribution to this 17%?
Major. The BJP has been contesting for the last 30 years and how many votes have they got?
When we launched a new party, immediately the BJP got 10% extra vote share.
So your party is responsible for the BJP's success?
Everybody has accepted that.
Your expectations this time?
5, 6 seats in Kerala.
Wayanad?
We are fighting strongly.
Do you think you are on a weak wicket?
No, no. We have a very strong wicket (laughs).
I am fighting with a non Malayali and Malayalis know that he can't do anything.
What has he done in Amethi? We don't want any Amethi kind of development in Wayanad (laughs).
Marvel is trying to get Black Panther a Best Picture nomination at the Oscars next year
'There is a need to regulate bought leaf factories'
Twitter to show users when a bad tweet is taken down
'Intel has a huge role to play in making 5G a success'
Rahul has all qualities to make a good PM: Tejashwi
aCommunalGameisPlayRahultotrying
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redpajama_set_name: RedPajamaCommonCrawl


After the Parliament rejected for the third time Prime Minister Theresa May's proposed deal to pull Britain out of the European Union on Friday, pressure was put on the sterling. The currency remained well above lows hit in December, in part because "markets have begun to price in a long delay and that's risk and sterling positive," said Greg Anderson, global head of foreign exchange strategy at BMO Capital Markets.
The GBP's movement led the dollar index higher, last up 0.07 percent to 97.274, helping it recover from an earlier drop on the weaker-than-expected report of U.S. inflation data.
Bloomberg reports that everyone is getting ready to attack Sweden's currency, including investors and the country's leaders.
• a business federation has accused the central bank of effectively devaluing the currency.
The krona is the worst-performing major currency this year, although strategists picked it as a world beater for 2019. Still, they began withdrawing their predictions after weak Swedish data.
On Friday, oil prices rose about 1 percent, having their biggest quarterly rise in a decade, as U.S. sanctions against Iran and Venezuela and OPEC-led supply cuts overshadowed concerns over a slowing global economy.
The May Brent crude oil futures contract, which expired Friday, gained 57 cents, or 0.8 percent, to settle at $68.39 a barrel, marking a first-quarter gain of 27 percent. The more-active June contract settled at $67.58 a barrel.
• following past week's supply decline, at 1.107 trillion cubic feet (Tcf), natural gas inventories are 551 Bcf (33.2%) under the five-year average and 285 Bcf (20.5%) below the year-ago figure.
On Friday, gold prices finished higher, just a day after it had posted the largest single-session percentage decline since Aug. 13.
June gold GCM9, -0.16% gained $3.20, or 0.2%, to end at $1,298.50 an ounce.
For the quarter, the precious metal rose by about 1.2%, but bullion posted a weekly decline of more than 1% and slipped by about 1.4% month to date, according to FactSet data.
The commodity failed to close above $1,300, a price seen as a key technical level, according to MarketWatch.com.
Stocks rallied into the close as optimism over U.S.-China trade talks seemed to overshadow the concerns about a slowing economic explosion. The session was marked by the S&P 500 performance, as the index had its best quarterly performance in nearly a decade.
• Nasdaq Composite Index COMP, +0.78% advanced 60.16 points, or 0.8%, to 7,729.32. DJIA, +0.82%.
On Friday, European shares rose, heading for best quarterly performance in four years, helped by encouraging signals from U.S.-China trade talks and a surge for the world's second-biggest apparel retailer, H&M.
• Germany's trade-sensitive DAX was up 0.3 percent.
Facebook 's (FB) Instagram app recently launched a Checkout feature that allows users to buy products and services directly. That's good news for the rates Instagram can charge for ads, argues Evercore ISI, especially since many are abandoning the flagship social-media site. Therefore, Facebook's other properties have taken on increased importance, and none has been as fruitful as Instagram, which surpassed one billion users last year.
Last week, Apple (AAPL) made a big, and unexpected service product announcement called Apple News+. Now, on the surface, this new service has virtually no competition, but it provides a much needed and rich content experience, for those who like to read. In comparison to having an annual subscription with premium-tier services like the Wall Street Journal and also the Los Angeles Times, that would cost around $8,000 per year (according to Finance.Yahoo.com), Apple News+ is very affordable.
Amazon (AMZN) announced an expansion of its Austin Tech Hub which would lead to the creation of 800 new tech jobs in fields such as software and hardware engineering, research science, and cloud computing. Together with its customer fulfilment facilities, Amazon has created more than 22,000 full-time jobs in Texas and since 2011 has invested over $7 billion in the state, including infrastructure and compensation to its employees.
Netflix (NFLX) dominates the premium video-streaming market. It began the year with 138.26 million paying accounts worldwide, and by the end of last weekend, the platform expects to reach 148.16 million streaming members.
Image: Key financial metrics for Alphabet (GOOG) and Baidu (BIDU).
Sources: Finance.Yahoo.com, S&P Capital IQ, company filings.
Sources: Reuters.com, Bloomberg.com, SPGlobal.com, Nasdaq.com, MarketWatch.com, Barrons.com, Finance.Yahoo.com.
The information presented herein does not constitute and does not intend to constitute Investment Advice. The information contained herewith is a compilation of public stock recommendations issued by various financial analysts and organised by Live News Recommendation in an easily presentable format, for information purposes only.
Key Way Investments Ltd does not influence nor has any input in formulating the information contained herein. The content herewith is generic and does not take into consideration individual personal circumstances, investment experience or current financial situation. Users/readers should not rely solely on the information presented herewith and should do their own research/analysis by also reading the actual underlying research. Users/readers should also consider the risk of encountering significant losses when trading CFDs. Therefore, Key Way Investments Ltd shall not accept any responsibility for any losses of traders due to the use and the content of the information presented herein. Past performance is not a reliable indicator of future results.


text:
Home News ASEAN
First Ooredoo SIM cards go on sale in Myanmar
by Arno Maierbrugger - Jul 31, 2014
Shops in Myanmar's second largest city Mandalay have begun selling a limited number of Ooredoo SIM cards, as the Qatari company remains tight-lipped about when its mobile phone cards will go on general sale.
The sale of affordable SIM cards has been hotly awaited since Ooredoo and Norway's Telenor were named as the winners of a competitive tender last year to become the first private firms to offer mobile phone services in Myanmar. The two companies enter the market alongside state-owned company Myanmar Post and Telecommunications (MPT), which has so far only distributed limited numbers of SIM cards through lotteries, fueling a black market for the sought-after cards.
Ooredoo Myanmar spokeswoman Thiri Kyar Nyo said she could not confirm when Ooredoo SIM cards were going on sale nationwide. All would be revealed at a press conference in Yangon on August 2, she said.
But a photographer for The Irrawaddy in Mandalay has seen mobile shops and vendors selling the SIMs since July 29, and numerous social media posts have shown people buying the cards. Local media reported that phone shops in Naypyidaw were also selling the SIM cards.
Phone shop workers in Mandalay said that SIM cards had been distributed to shops ready for an official launch on August 2, but some shops had already started selling them.
Mobile Mother phone shop in Mandalay is selling the SIMs, which have a recommended retail price of 1,500 kyat (about $1.50), for 1,700 kyat each to people with national identity cards. A member of staff said the shop, which is an official Ooredoo distributor, sold out of its 1,000 SIM cards within a day.
The cards come with 900 free minutes and 900 free SMS text messages to other Ooredoo phones, 90 minutes of free calls and 90 free texts to MPT users, and 20 megabytes of Internet data to be used between August 2 and 15, according to phone shop workers.
Calls cost 25 kyat per minute between Ooredoo users, or 35 kyat to other networks, and texts and 1 MB of data also cost 25 kyat each, they said. Although details of Ooredoo's data plans have not been announced, some on social media have already complained that 25 kyat per MB would add up to a high cost for frequent Internet users, who often use 1 gigabyte, or 1,000 MB, per week.
Some phone shops in Mandalay are only selling Ooredoo SIM cards to customers who also buy a phone handset, according to a salesperson from Any Call Mobile, a Telenor representative shop, who also said the unofficial launch had not impacted on phone sales at his shop.
In expectation of the new competition, MPT has been distributing more of its SIMs and has said it will soon put them on general sale. The company has tied up with Japanese firms KDDI and Sumitomo in an attempt to hold on to its dominant position in the Myanmar phone market.
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Shops in Myanmar's second largest city Mandalay have begun selling a limited number of Ooredoo SIM cards, as the Qatari company remains tight-lipped about when its mobile phone cards will go on general sale. The sale of affordable SIM cards has been hotly awaited since Ooredoo and Norway's Telenor were named as the winners of a competitive tender last year to become the first private firms to offer mobile phone services in Myanmar. The two companies enter the market alongside state-owned company Myanmar Post and Telecommunications (MPT), which has so far only distributed limited numbers of SIM cards through lotteries,...
Internet data
Myanmar Post
Ooredoo Myanmar
Ooredoo SIM
Malaysia seeks to boost outsourcing business
Moody's upgrades Vietnam to B1; outlook stable
Arno Maierbrugger
Piracy and armed robberies on the rise in Singapore Strait
The number of piracy cases and armed robberies on vessels in the Singapore Strait has reached a...


text:
Q: php email using PHPMailer not working Im having trouble sending an email via my web form, I am using PHP and a PHPMailer Class
My Form Code iS
<form class="cd-form floating-labels" method="post" action="email.php" enctype="multipart/form-data">
    <fieldset>
        <legend>Contact Us</legend>

            Name
            <input class="user" type="text" name="cd-name" id="cd-name" value="<?php if(isset($_POST["cd-name"])){echo $_POST["cd-name"];}else{echo "";}?> required>

            Company
            <input class="company" type="text" name="cd-company" id="cd-company" required>

            Email
            <input class="email" type="email" name="cd-email" id="cd-email" required>

            Contact No
            <input class="phone" type="text" name="cd-phone" id="cd-phone" required>

    </fieldset>

    <fieldset>

            Project description
            <textarea class="message" name="cd-message" id="cd-message" required></textarea>

        Another upload:
        <input type="file" name='cd-upload' id='cd-upload' />

            <select name="cd-hearsay" class="budget">
                <option value="0">Where Did You Hear About Us?</option>
                <option value="1">Google</option>
                <option value="2">Friend / Family</option>
                <option value="3">Ad On A Website</option>
            </select>

            Coupon Code
            <input class="coupon" type="text" name="cd-coupon" id="cd-name">

            <input type="submit" value="Send Message">

    </fieldset>
</form>

and My email.php code is
    <?php
require("class.phpmailer.php");

// define variables and set to empty values
$name = $company = $email = $phone = $message = $upload = $hearsay = $coupon =  "";
$nameErr = $companyErr = $emailErr = $phoneErr = $messageErr = $uploadErr = $hearsayErr = $couponErr =  "";

function clean($data) {
   $data = trim($data);
   $data = stripslashes($data);
   $data = htmlspecialchars($data);
   return $data;
}

//clean varibles
$company = clean($_POST['cd-company']);
$upload = clean($_POST['cd-upload']);
$hearsay = clean($_POST['cd-hearsay']);
$coupon = clean($_POST['cd-coupon']);

//validate varibles

//Check Name
if(empty($_POST['cd-name']))
{
    $nameErr = "Name Field is Required";
}
elseif(strlen($_POST['cd-name']) <= 3)
{
    $nameErr = "Please provide your full name";
}
elseif(!ctype_alpha($_POST['cd-name']))
{
    $nameErr = "Please only use letters in your name";
}
else
{
    $name = clean($_POST['cd-name']);
}

//Check Email
if (empty($_POST["cd-email"]))
{
    $emailErr = "Email is required";
}
elseif(!filter_var($_POST["cd-email"], FILTER_VALIDATE_EMAIL))
{
    $emailErr = "Invalid Email Format";
}
else
{
    $email = clean($_POST["cd-email"]);
}

//Check Phone
if(empty($_POST['cd-phone']))
{
    $phoneErr = "Phone number is required";
}
elseif(!is_numeric($_POST['cd-phone']))
{
    $phoneErr = "Please use numers only";
}
else
{
    $phone = clean($_POST['cd-phone']);
}

//Check Message
if(empty($_POST['cd-message']))
{
    $messageErr = "Message is blank!";
}
elseif(!ctype_alnum($_POST['cd-message']))
{
    $messageErr = "Please use numbers and letters only";
}
else
{
    $message = clean($_POST['cd-message']);

}

//Check Upload File Types / Size
if(!empty($_POST['cd-upload']))
{
    //Get the uploaded file information
    $name_of_uploaded_file = basename($_FILES['uploaded_file']['name']);

    //get the file extension of the file
    $type_of_uploaded_file = substr($name_of_uploaded_file, strrpos($name_of_uploaded_file, '.') + 1);
    $size_of_uploaded_file = $_FILES["uploaded_file"]["size"]/1024;//size in KBs

    //Settings
    $max_allowed_file_size = 100; // size in KB
    $allowed_extensions = array("doc", "xls", "txt");

    //Validations
    if($size_of_uploaded_file > $max_allowed_file_size )
    {
      $uploadErr .= "\n Size of file should be less than $max_allowed_file_size";
    }

    //------ Validate the file extension -----
    $allowed_ext = false;
    for($i=0; $i<sizeof($allowed_extensions); $i++)
    {
      if(strcasecmp($allowed_extensions[$i],$type_of_uploaded_file) == 0)
      {
        $allowed_ext = true;
      }
    }

    if(!$allowed_ext)
    {
      $uploadErr .= "\n The uploaded file is not supported file type. ".
      " Only the following file types are supported: ".implode(',',$allowed_extensions);
    }

    //copy the temp. uploaded file to uploads folder
    $path_of_uploaded_file = $upload_folder . $name_of_uploaded_file;
    $tmp_path = $_FILES["uploaded_file"]["tmp_name"];

    if(is_uploaded_file($tmp_path))
    {
      if(!copy($tmp_path,$path_of_uploaded_file))
      {
        $uploadErr .= '\n error while copying the uploaded file';
      }
    }
}

if(!$nameErr && !$emailErr && !$phoneErr && !$messageErr && !$uploadErr)
{
    echo "no errors";
    $mail = new PHPMailer();

    $mail->IsSMTP();                                      // set mailer to use SMTP
    $mail->Host = "send.one.com";  // specify main and backup server
    $mail->SMTPAuth = true;     // turn on SMTP authentication
    $mail->Username = "jswan";  // SMTP username
    $mail->Password = "secret"; // SMTP password

    $mail->From = $email;
    $mail->FromName = $name;
    $mail->AddAddress("testemail@hotmail.co.uk", "Looty Jackinson");
    #$mail->AddAddress("ellen@example.com");                  // name is optional
    $mail->AddReplyTo("info@example.com", "Information");

    $mail->WordWrap = 50;                                 // set word wrap to 50 characters
    $mail->AddAttachment("uploads");         // add attachments
    #$mail->AddAttachment("uploads/image.jpg", "new.jpg");    // optional name
    $mail->IsHTML(true);                                  // set email format to HTML

    $mail->Subject = "Here is the subject";
    $mail->Body    = "This is the HTML message body in bold!";
    $mail->AltBody = "This is the body in plain text for non-HTML mail clients";

    if(!$mail->Send())
    {
       echo "Message could not be sent.
";
       echo "Mailer Error: " . $mail->ErrorInfo;
       exit;
    }

    echo "Message has been sent";
}
else
{
    echo "errors";
    print_r($nameErr);
    print_r($emailErr);
    print_r($phoneErr);
    print_r($uploadErr);
    #header("index.php");
}
?>

but this is resulting in the following error, no errorsCould not access file: uploads Warning: require_once(class.smtp.php): failed to open stream: No such file or directory in /customers/2/9/2/kernow-connect.com/httpd.www/contact-form/class.phpmailer.php on line 760 Fatal error: require_once(): Failed opening required 'class.smtp.php' (include_path='.:/usr/share/php') in /customers/2/9/2/kernow-connect.com/httpd.www/contact-form/class.phpmailer.php on line 760
i am really unsure what i am doing at this point and would really appreciate some help please!
You can see the problem(s) at http://www.kernow-connect.com/contact-form/form.php
I can post the content of the PHPMailer.php if needed
Many Thanks
Luke

A: You didn't read the docs (the readme tells you what you need to know) or the sample code supplied with PHPMailer, and you're probably using an old version. To quote from the readme:

At the very least you will need class.phpmailer.php. If you're using SMTP, you'll need class.smtp.php, and if you're using POP-before SMTP, you'll need class.pop3.php. For all of these, we recommend you use the autoloader too as otherwise you will either have to require all classes manually or use some other autoloader.

Look before you post.


text:
Фінал Кубка Італії з футболу 1983 — два фінальних матчі розіграшу Кубка Італії сезону 1982—1983, в яких зустрічались «Ювентус» і «Верона».

Шлях до фіналу

Перший матч

Повторний матч

Посилання
 Кубок Італії на rsssf
 Кубок Італії на xoomer.virgilio.it

1983 у футболі
1983 в італійському спорті
Фінали кубка Італії з футболу

redpajama_set_name: RedPajamaWikipedia


Notrax's 474 1/2" Ergo Mat™ has a corrugated ribbed top surface of resilient SBR rubber that provides directional traction to reduce slips, and offers superior anti-fatigue support for applications where workers are required to stand for long periods of time. The top surface is combined with a dense closed cell foam base utilizing NoTrax® exclusive UniFusion™ technology virtually eliminating the possibility of de-lamination. Now with RedStop™, a uniquely engineered technology that eliminates the slipping and sliding of NoTrax® floor mats on all types of smooth floor surfaces such as vinyl composite tile, painted or epoxy coated concrete, vinyl sheet flooring, carpet, and ceramic tile. Production time: 3 to 5 business days.
Also available in 1" thickness.
1. Corrugated ribbed top surface of resilient SBR rubber is combined with dense closed cell foam base utilizing NoTrax® exclusive UniFusion™ technology.


Recently I updated my two sites, to make them more efficient. Instead of writing these in PHP and have them constantly poll my server which did the lookups and served the result, they have been redone in nodejs. The main push into doing so was the fact that my host locked out my account because I was "Using 25% of the servers CPU", which apparently was too much. Now, this uses the MTGox streaming API and re-serves that. For Litecoin it still polls, but no more need to database the result and pass it back to the clients every few seconds. Using Express VHost I was able to serve both domains through one NodeJS application on a single .
Today, I have added a TCP socket server as part of the script. This allows my new Android application to connect and also stream data. It will only send the changed results through the socket, instead of all the data each time. I have put together a very simple Android application to interface with this.
I plan on open sourcing the application, as well as a full "Crypto API" when time becomes available.


Location! Location! Totally remodeled beautiful home! Open living room and dining room. 3 bedrooms with all walk-in closets. Master bedroom has double sinks, garden tub and separate shower. Loft is huge for the kids to entertain and could be easily converted to 4th bedroom. All new stainless appliances! It will not last long! MUST SEE!
Directions:SR 37, Turn East on 191 St, Turn south on Promise Rd, Turn right to Monarch Springs Rd. The property is on your left.
Listing provided courtesy of Curtis Realty, LLC.


by line and I can't see any diffeence between the two.
The top bar not showing up is 16 lines from the top of the code.
I'm probably mising a tag but can't find it.
> Hi, I have a site and the top bar is not showing up when I view the page.
> by line and I can't see any diffeence between the two.
> The top bar not showing up is 16 lines from the top of the code.
> "
"
> I'm probably mising a tag but can't find it.


text:
Our rail stations Active navigation Active navigation path
ShopVille-Zurich main station
Welcome to our stations.
Zurich Enge
Zurich Oerlikon
Zurich Stadelhofen
Use two fingers to operate the card.
Geodata:
Federal Office of Topography
http://www.imagico.de/Link opens in new window.
Map production:
www.trafimage.chLink opens in new window.
www.evoq.chLink opens in new window.
www.geops.chLink opens in new window.
General information on construction works, disruptions and delays throughout Switzerland.
Most up-to-date notifications
You will find below the latest information on strikes and interruptions in the event of larger rail traffic disruptions.
No stations were found for your search. Try again with another search term.
Make the most of the extended opening hours at SBB railway stations, where pharmacies, restaurants, takeaways, convenience stores, SBB services, shops and many more are open for you – 365 days a year, from early till late.
ShopVille-Zurich main station.
Switzerland's biggest railway station ShopVille-Zurich main station lies at the heart of the city nestled on banks of the River Limmat. The shopping centre is open for business from early morning 'til late evening throughout the year.
More info about ShopVille-Zurich main station.
Bern station.
Situated right in Switzerland's capital, Bern station allows you to take advantage of long opening hours 365 days a year. It is the city's main meeting point and public transport hub. Home to more than 70 shops, the station's shopping centre offers a wide selection of products, food, drink and services.
More info about Bern station.
Basel SBB station.
Basel SBB station is Europe's largest border station. It has an array of restaurants, takeaway outlets, services and various shops as well as a health centre with a pharmacy.
More info about Basel SBB station.
Geneva Cornavin station.
Geneva Cornavin station is the beating heart of public transport for the city and the wider region. The shopping centre at Geneva Cornavin station includes a pharmacy, numerous takeaway outlets and a range of services and shops.
More info about Geneva Cornavin station.
Lucerne station.
Situated on the shores of Lake Lucerne, Lucerne station enjoys a picturesque backdrop and offers a variety of shops that boast particularly long opening hours among other things.
More info about Lucerne station.
Further stations.
Find your station.
More info about Further stations.
Trafimage maps and station plans.
SBB offers various maps and station plans in the Trafimage system.
More info about Trafimage maps and station plans.
Further stations.Total 28
Further stations. Part 1


Considering the future development of both the eastern town area, the presentation includes the regeneration of the Port Royal and the Ham Lane car park.
Eastern Town Development A proposal for a sustainable and pedestrian oriented development, to be achieved by the introduction of two new interlinked pedestrian spaces, the reintroduction of historic streets at the Ham car park and a paved crescent at the end of the Esplanade. Massed around the street pattern are mixed use residential and commercial spaces with the community cultural functions overlooking the Ham and opening directly onto the seafront. The scale of the development is consistent with the existing urban fabric, it is orientation to suit the grain of the town and for passive solar gain.
Proposed is a scheme presenting a significant social and cultural asset, accommodation for the use and enjoyment of the community whilst adding diversity to the visitor's experience providing a lasting impression of the resort. Occupying a beautiful and important geographical location this significant community and cultural complex will be a mixed development in which to live, work and play.
The scale and massing of the development is consistent with the existing buildings and surroundings landscape. Towards the river and overlooking the Ham it will be sensitively nested into the outstanding natural habitat. The main entrances to the cultural centre will open directly onto the newly paved area on the seafront and is linked to improved pedestrian access in the Ham Lane vicinity. To reduce physical impact, the upper floors of the complex are stepped back with a single storey observation deck, the belvedere projected forward to offer an unobstructed vista up the esplanade and along the coast. The centre consists of a cluster of spaces with sheltered public areas of generous proportions. To maximize the basement floor area and to provide extra protection from potential flooding the major amenities are elevated above a podium. Taking advantage of solar gain the centre provide a winter garden and sun terrace sheltered from the colder northern offshore winds.
The above was presentated to the Vision for Sidmouth Group September 2008.


text:
Sheffield Wednesday complete double deal
Sheffield Wednesday have completed the permanent signings of defenders Matt Young and Ed Sanders from Southampton and Stoke respectively.
Right-back Young, 20, and centre-half Sanders, 18, have both put pen to paper on one-year deals.
Young started out at Tottenham before joining Southampton aged 16. He signed his first professional contract at St Mary's in May 2012.
"I've played with players who pushed on into the first team there including the likes of Luke Shaw and Calum Chambers and good luck to them," Young told the Owls' official website.
"Now I'm happy to be here and to take my own path.
"I want to get a good pre-season under my belt, show the gaffer what I can do and try to get in his thoughts for the start of the season."
Sanders began his career path at Portsmouth and at 16 was handed a two-year scholarship at Stoke.
"This is a great opportunity for me," he said.
"You can tell after just five minutes of stepping through the door how big this club is and the history that goes along with that.
"Hopefully I can continue to develop and enjoy the experience over the course of the next year."


Zumiez is an American apparel company and store chain which specializes in clothing and footwear inspired by youth and skate culture. Gift cards can be used at over 500 Zumiez locations in the United States.
Sell Zumiez gift cards on Cardpool.


The most effective types of employee training are suited for employees with diverse experience and a wide range of skills.
While individual training is tailored to a specific role, the framework for training new employees should apply to everyone.
Make your employee training simpler and more productive — instantly.
Diversity of thought drives business success by enabling out-of-the box problem solving — a mix of professional expertise stimulates employee growth. It's a win-win situation.
While diversity is worth striving for, it is not without a few hurdles, especially when it comes to developing employee training. The biggest mistake an employer can make is assuming that there is a one-size-fits all approach to training.
An effective employee training plan must not only be adaptable and well-rounded but also appeal to the different backgrounds and learning styles of a diverse group of employees.
We know fish can't climb trees, just like we know everyone learns and retains information in different ways. It's neither fair nor effective to apply the same types of employee training to all staff and expect the same positive outcome.
Social scientists have identified three main learning styles through which most learning occurs: visual, auditory and kinaesthetic. Individuals may learn most effectively in one style, or a blend of two or three.
It is important to remember that you do not need to create separate types of employee training plans to suit each type of learner. Instead, try to implement aspects of each into any enterprise training plan. Different types of employee training sessions built to engage each kind of learner will have the best chances for success.
It's important to understand how different learners best absorb information in any context, but especially in a digital work environment. As technology continues to permeate the modern workplace, companies need employees to gain proficiency on a variety of digital solutions.
To do so effectively, the types of employee training you administer should appeal to all learners.
Visual learners best retain new information by seeing the material firsthand and visualizing concepts. Training methods that are tailored to visual learners should ideally involve textual and graphic elements.
Lectures are less beneficial for this type of learner unless they are accompanied by some type of visual aid.
When it comes to learning digital platforms, visual learners will appreciate types of employee training with on-screen cues. The the visual prompt will guide them during the moment of need and stick in their memory better than listening to an instructor.
Unlike visual learners, for auditory learners, hearing is believing. They learn best by hearing someone explain a concept and then applying it to their daily work.
Learning digital platforms can be challenging for auditory learners because generally, lectures are an ineffective software training method. However, many eLearning and LMS and Digital Adoption Platforms include features that provide audio effects.
Auditory learners also love to talk about what they've learned with others. After a lesson, hold a discussion so that the employees can review the information out loud and hear others' perspectives on the content.
Kinaesthetic learners can engage through lectures and discussions, but they thrive on interactivity. Throughout the lecture, create quizzes or activities that get employees out of their seats and have them practice what they've just learned.
Hands-on learning is the best training method for these learners. Examples could include case studies, role playing and assessment activities.
It may seem difficult to mesh all of these types of employee training together, but it is essential to be adaptable and open to all learning styles.
Using a program like WalkMe for employee training ensures effective software learning, and boosts employee engagement.
Training is challenging but it can be an enjoyable experience for everyone. Embracing diversity and keeping the different types of training and learning styles in mind will help ensure a successful training program for all employees.
WalkMe helps ensure training is effective for all employees. Discover how.


text:
Çapalı is a village in the Şahinbey District, Gaziantep Province, Turkey. The village is inhabited Turkmens and had a population of 154 in 2022. The inhabitants are Alevis belonging to the Dede Kargın, Hacım Sultan and Baba Kaygusuz ocaks.

References

Villages in Şahinbey District


Elle is a premium child theme from StudioPress Marketplace which works on Genesis Theme Framework. This theme is idle for modern business websites or portfolio websites. The best thing I like about this theme is that it is a beautiful multi-column business style child theme.
We don't care what they say, function is fashion.
You're in the city. you're in the country. you've got stories and pictures and ideas that can't be contained by mere…stereotypes. let the Elle theme frame your life or business the way you want it.
Elle comes with features like multiple columns homepage, custom coded widgets, essential page templates, featured video section, social media integration and more.
Share your views via comments and do not forget to follow WebGuide4U on Twitter for more updates on WordPress Themes.
Gladica is a premium WordPress Theme from KarmaThemes which is specifically designed for company or portfolio website. It is a clean and feature rich WordPress Theme which incorporates designing with typography in combination with equally beautiful graphics and tons of useful features. In addition to this, this theme comes with features like stylish typographic layout, 3 alternative color schemes, custom page templates, collection of easy to use shortcodes, theme documentation guide, theme admin option panel and many more.
Jay is a premium WordPress Theme from Karma Themes which is specifically designed for portfolio websites. The best thing I like about this theme is that, by using this theme web developers, photographers, painter and other artist can easily showcase their skills online.
This is a clean and colorful WordPress Theme which comes with features like easy to customize homepage layout, vertical jQuery powered scrolling to display image thumbnail, built in shortcodes, custom page templates, theme documentation guide, theme admin option panel and many more.
StudioPress offers professionally designed WordPress Theme and always come up with new updates on previously released WordPress Theme. Today, StudioPress announced a new version of Corporate Child Theme, i.e, Corporate 2.0.
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Corporate 2.0 underwent a major code update which means there's not an easy update path. If you're happy with your site build on a previous version of the theme, then there's no need to update. The first part of the update was a complete rewrite of CSS which is based on the updated Genesis Sample child theme. This will allow for more efficient coding and easier customization. In addition to that, we rewrite the home.php file so upon theme activation, the standard loop loads until the home widgets are placed into their appropriate areas.
If you have any query let me know via comments and do not forget to follow WebGuide4U on Twitter for more updates on StudioPress Themes.


The original rendering of this historic creed explicitly condemns abortion.
The Hippocratic Oath was revolutionary for its unyielding devotion to the preservation of individual human life. It stood in marked contrast to the more primitive medical traditions that blurred the lines between killing and curing. In its original form, the oath prohibits both euthanasia and abortion.
Opposition to abortion from within the medical community is hardly a modern phenomenon. Though advancing technology has only recently given us clear access to the astonishing development taking place within the womb, doctors have long known that human embryos and fetuses are nothing less than tiny human beings.
Like the Declaration of Geneva, a 1983 amendment to the International Code of Medical Ethics removed the "conception" clause but still maintained a physician's obligation to preserve human life "from the beginning"8—language which survived until 2006.9 Despite modern efforts to narrow the pool of persons protected by these historic creeds, their original intent should be clear. Destroying a human being before or after birth was considered an unconscionable medical paractice, particularly in the aftermath of the Holocaust.
Even without referencing abortion directly, the doctors who take this oath—if they're honest—are still committing themselves to the preservation of human life, which traces all the way back to conception. The fact that countless abortionists have blithely bound themselves to this oath doesn't negate its original intent. We can change the language of historic moral documents—to accommodate an ethically-suspect practice, but we can't change the morality itself. Simply put, killing an innocent human being is not a morally-acceptable cure to unwanted pregnancy.
This page was last updated on November 27, 2018. To cite this page in a research paper, visit: "Citing Abort73 as a Source."
Margaret Mead to Maurice Levine. Recounted in Five Days at Memorial: Life and Death in a Storm-Ravaged Hospital, by Sheri Fink. (Broadway Books, 2014) 386.
Jill Stephenson, Women in Nazi Society, Volume 35 (Routledge, 2012) 62-63.


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Corvette News
2020 Chevy Corvette Stingray vs the world: How it compares on paper
How do the Porsche 911, Acura NSX and Nissan GT-R stack up? How about the Toyota Supra or Porsche Cayman?
Joel Stocksdale
Jul 22nd 2019 at 3:05PM
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The 2020 Chevy Corvette Stingray in its base form offers an astonishing amount of performance for the money. In fact, so impressive is the car's spec sheet that the Corvette kind of exists in two different competitive sets: one of cars priced similarly, and another with cars of similar performance and reputation.
To get a feel for how it handles each of these segments, we've compiled specifications for those two sets of players. You can find the first set below, which looks at cars of roughly the same price point. Following that is a bit of analysis, and then there's a chart of cars with similar performance and reputation. And that chart will also have some analysis.
Though final pricing for the Corvette hasn't been announced yet, we know the Corvette will start at less than $60,000. And as far as pricing goes, its closest competitor is the Porsche 718 Cayman, which also starts at just under $60,000. Both are mid-engined and rear-drive, but the Corvette offers an extra 195 horsepower and 190 pound-feet of torque. The Cayman does boast a curb weight of right around 3,000 pounds, so it weighs a few hundred pounds less than the Corvette, but it's likely not enough to make up for the power deficit. The Corvette's sub-3.0-second 0-60 time bears this out against the Cayman's best 4.5-second run. Impressively, though, the Cayman has more cargo space than the Corvette in a package that's nearly 10 inches shorter. The Cayman also still offers a manual option for those that prefer self-shifting.
The 2020 Toyota Supra is on the cheap end of this sports car class, just crossing $50,000. It also boasts more power than the Cayman, though it's still down by 160 ponies and 105 pound-feet of torque to the C8. It's also about as roomy as the Corvette, despite being about the same size as the Cayman. Cargo space is a bit tighter. Its driving characteristics will likely differ, too as the Supra sits on a front-engine platform. It might even feel closer to a C7 Corvette in some ways.
The other mid-engine entry in this price range is the 2019 Alfa Romeo 4C Spider. Its small 1.7-liter turbo inline-4 only makes 237 horsepower and 258 pound-feet of torque, but it's also far and away the lightest of this group at 2,487 pounds. That's roughly 1,000 pounds lighter than the Corvette. It isn't as fast as the Corvette in a straight line, but that lightness surely pays dividends in cornering and braking. It's a small package, several inches shorter than the rest of these cars, and that shows in its miniscule 3.7 cubic feet of cargo space and lack of shoulder room. You pay more for less as the Alfa starts at just over $68,000. The Alfa is also surprisingly frugal, though, with a combined fuel economy of 28 mpg, beating out the Supra at 26 and the Cayman at 25. While fuel economy for the Corvette hasn't been announced, the current base C7 gets between 18 and 19 mpg combined. The new one will probably continue to be less frugal than these smaller, less powerful cars.
Now we move on to cars that would more traditionally be Corvette competitors, chief among which is the Porsche 911. As the base 992 911 hasn't been revealed yet, we're sticking with the still on-sale 991 911 Carrera. Its twin-turbo flat-6 comes up 125 horses and 139 pound-feet of torque shy of the Corvette. And despite having a couple hundred pounds less to carry around than the Corvette, the best 0-60 time it can muster is 4.0 seconds, over a second behind the Corvette. It does feature solid fuel economy ranging between 23 and 25 mpg. It has a bit more cargo space, too, when counting the rear seat area. But at $92,000, the 911 has quite a price premium over the faster Corvette.
The Nissan GT-R is another familiar Corvette fighter. Its twin-turbo V6 actually makes 70 more horsepower and nearly the same amount of torque. Nissan hasn't released an estimated 0-60 time for the latest GT-R, but past models have beaten the 3.0-second mark, putting it right on par with the Corvette. The Corvette should weigh a couple hundred pounds less than the portly GT-R, but the GT-R makes up for some of its weight with all-wheel-drive traction. The GT-R is roughly on par for practicality, too. Nissan only gives cargo space for the trunk at 8.8 cubic feet. But the GT-R does have rear seat space that could be used and should put it about equal to the Corvette's 12.6 cubic feet of space. The GT-R is still expensive though, ringing in at around $115,000.
Then there's the 2019 Acura NSX, which is close in philosophy to the Corvette. It's a mid-engine sports car designed to offer lots of performance and practicality. It's the most powerful of this set with 573 horsepower and 476 pound-feet of torque. It comes with a very different powertrain than the Corvette, as it uses a twin-turbo V6 and three electric motors. With a 0-60 time of 3 seconds flat, it's slightly slower than the Corvette. But it does return combined fuel economy of 21 mpg, which will probably surpass the 'Vette. Its electric motors also allow it to do some impressive torque vectoring tricks to improve handling. Inside, the NSX is roomier than the Corvette, but its cargo capacity is just 4.4 cubic feet. The NSX is also comparatively expensive at nearly $160,000.
What all of this reveals is that there isn't really a car that can provide Corvette performance for a Corvette price. And even for tens of thousands more dollars, the competition is only barely matching it. This new Corvette is shaping up to be an amazing performance bargain.
Featured Gallery2020 Chevrolet Corvette Stingray
Chevrolet Corvette Information
More Corvette Information
Compare the 2022 Chevrolet Corvette side-by-side against similar vehicles
2022 Porsche 718 Cayman
MSRP: $55,900 - $125,400


text:
@import FBSnapshotTestCase;
#import <XCTest/XCTest.h>

#import "STDSChallengeResponseViewController.h"
#import "STDSChallengeResponseObject+TestObjects.h"

@interface STDSChallengeResponseViewControllerSnapshotTests: FBSnapshotTestCase

@end

@implementation STDSChallengeResponseViewControllerSnapshotTests

- (void)setUp {
    [super setUp];

    /// Recorded on an iPhone XR running iOS 12.1
    self.recordMode = NO;
}

- (void)testVerifyTextChallengeDesign {
    STDSChallengeResponseViewController *challengeResponseViewController = [self challengeResponseViewControllerForResponse:[STDSChallengeResponseObject textChallengeResponseWithWhitelist:NO resendCode:NO] directoryServer:STDSDirectoryServerCustom];
    [challengeResponseViewController view];

    [self waitForChallengeResponseTimer];

    STPSnapshotVerifyView(challengeResponseViewController.view, @"TextChallengeResponse");
}

- (void)testVerifySingleSelectDesign {
    STDSChallengeResponseViewController *challengeResponseViewController = [self challengeResponseViewControllerForResponse:[STDSChallengeResponseObject singleSelectChallengeResponse] directoryServer:STDSDirectoryServerCustom];
    [challengeResponseViewController view];

    [self waitForChallengeResponseTimer];

    STPSnapshotVerifyView(challengeResponseViewController.view, @"SingleSelectResponse");
}

- (void)testVerifyMultiSelectDesign {
    STDSChallengeResponseViewController *challengeResponseViewController = [self challengeResponseViewControllerForResponse:[STDSChallengeResponseObject multiSelectChallengeResponse] directoryServer:STDSDirectoryServerCustom];
    [challengeResponseViewController view];

    [self waitForChallengeResponseTimer];

    STPSnapshotVerifyView(challengeResponseViewController.view, @"MultiSelectResponse");
}

- (void)testVerifyOOBDesign {
    STDSChallengeResponseViewController *challengeResponseViewController = [self challengeResponseViewControllerForResponse:[STDSChallengeResponseObject OOBChallengeResponse] directoryServer:STDSDirectoryServerCustom];
    [challengeResponseViewController view];

    [self waitForChallengeResponseTimer];

    STPSnapshotVerifyView(challengeResponseViewController.view, @"OOBResponse");
}

- (void)testLoadingAmex {
    STDSChallengeResponseViewController *challengeResponseViewController = [self challengeResponseViewControllerForResponse:nil directoryServer:STDSDirectoryServerAmex];
    [challengeResponseViewController view];
    [challengeResponseViewController setLoading];

    STPSnapshotVerifyView(challengeResponseViewController.view, @"LoadingAmex");
}

- (void)testLoadingDiscover {
    STDSChallengeResponseViewController *challengeResponseViewController = [self challengeResponseViewControllerForResponse:nil directoryServer:STDSDirectoryServerDiscover];
    [challengeResponseViewController view];
    [challengeResponseViewController setLoading];

    STPSnapshotVerifyView(challengeResponseViewController.view, @"LoadingDiscover");
}

- (void)testLoadingMastercard {
    STDSChallengeResponseViewController *challengeResponseViewController = [self challengeResponseViewControllerForResponse:nil directoryServer:STDSDirectoryServerMastercard];
    [challengeResponseViewController view];
    [challengeResponseViewController setLoading];

    STPSnapshotVerifyView(challengeResponseViewController.view, @"LoadingMastercard");
}

- (void)testLoadingVisa {
    STDSChallengeResponseViewController *challengeResponseViewController = [self challengeResponseViewControllerForResponse:nil directoryServer:STDSDirectoryServerVisa];
    [challengeResponseViewController view];
    [challengeResponseViewController setLoading];

    STPSnapshotVerifyView(challengeResponseViewController.view, @"LoadingVisa");
}

- (STDSChallengeResponseViewController *)challengeResponseViewControllerForResponse:(id<STDSChallengeResponse>)response directoryServer:(STDSDirectoryServer)directoryServer {
    STDSImageLoader *imageLoader = [[STDSImageLoader alloc] initWithURLSession:NSURLSession.sharedSession];

    STDSChallengeResponseViewController *vc = [[STDSChallengeResponseViewController alloc] initWithUICustomization:[STDSUICustomization defaultSettings] imageLoader:imageLoader directoryServer:directoryServer];
    [vc setChallengeResponse:response animated:NO];
    return vc;
}

- (void)waitForChallengeResponseTimer {
    (void)[XCTWaiter waitForExpectations:@[[self expectationWithDescription:@""]] timeout:2.5];
}

@end

redpajama_set_name: RedPajamaGithub


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Anyway, I remember us driving in that old Jag over to Wood Green, which is in London, not far from the famous Alexandra Palace. We were visiting one of Earl's clients who live in a Victorian town house on the west side of Wood Green.
Earl banged on the door, and this attractive middle-aged West Indian lady answered the door. She had the manner of a queen, immaculate deportment, and somehow you were going to do as she said, whether you liked it or not.
She was referring to me. Well, I was only about 21 at the time, and hardly had the appearance suited to meeting a queen – or somebody who thought she was a queen.
So she ushered us into her dinning room, and Earl laid his deck of old poker cards on the dinning table. The queen sat down facing Earl. I sat to the side.
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The queen's faced turned ashen. Earl had hit a nerve. If Earl's reading was on the money, it struck me that maybe Eastern Bloc crime barons were looking to move in on the operation she was involved in.
When Earl's reading was done, the queen slapped a grand on the table as payment and ushered Earl and I out very quickly. She'd obviously got things on her mind that needed dealing with fast.
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Everybody was scared of them. At least for a while – until some other syndicate moved in.


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