There seems to be no end to the disillusionment we are experiencing with both religious and political leaders. The latest, of course, comes from the revelations concerning the long-time involvement of the Reagans in astrology and the President's sad enslavement to lucky charms and other superstitions. While Mrs. Reagan reportedly "doesn't have a deep faith in God," the President claims to be a born-again Christian. Yet he has for years submitted to occult beliefs which made him the virtual prisoner of an astrologer, who literally confined the President to the White House on the many days it was "astrologically dangerous" for him to go out. It seems incredible that affairs of state at the highest level, including Soviet-American summit meetings, signing of disarmament treaties, etc., could be scheduled only when the zodiac allowed, thus seriously reducing the President's effectiveness. Yet that is the shocking revelation contained in For the Record, the account by former Secretary of the Treasury and White House Chief of Staff DonaldT. Regan of his years in Washington, D.C.
Of course the President had admitted to some such follies more than twenty years ago, but most observers had assumed that, with his open confession of Christianity and bolder stand for biblical principles in recent years, his occultism had been abandoned. We were wrong. Instead, these superstitions, especially astrology, in what Regan calls "probably the most closely guarded domestic secret of the Reagan White House," have gained a stronger hold than ever—much stronger than any outsiders suspected.
To understand the seriousness of the situation, not only for the First Family but for all Americans, we need to consider two factors: (1) that such practices are not confined to the Reagans, but are widespread throughout America; and (2) that God condemns these practices in the strongest terms, has severely judged Israel and many other nations for such abominations, and thus America is in grave danger of suffering similar punishment.
First of all, it is the utmost hypocrisy for the media to criticize the Reagans for what is so widely accepted and practiced by the majority of Americans, including sports heroes, business and political leaders, educators, and media personalities themselves. As we mention in America: The Sorcerer's New Apprentice, this country is in the midst of the greatest occult revival in history. Hundreds of newspapers across America carry daily astrology columns, which are consulted by tens of millions of Americans. Carl Jung had great respect for astrology and used it in his analysis, as do many of today's psychologists and psychiatrists. Top athletes and coaches have certain hats, or socks, or numbers, or days of the week which they are convinced bring "good luck," and no amount of evidence can persuade them otherwise. The superstitious fears still prevailing in the space age dictate that the "unlucky" thirteenth floor of most high-rise hotels and office buildings simply does not exist. Even skeptic Carl Sagan, the pagan high priest of cosmos worship, though a critic of astrology, declares, "If we must worship a power greater than ourselves, does it not make sense to revere the Sun and stars?"
Americans have fallen into numerous occult practices which attempt to utilize and control supernatural powers allegedly innate in the universe. Thus the creation is worshiped instead of the Creator (see Rom 1) and mankind is turned from the true God to substitute powers, i.e., to idols. This idolatry is the essence of the "New Age"—which is simply a continuation under new names of the ancient "doctrines of devils" and accompanying occult practices that have always permeated all cultures. Israel was eventually destroyed by God's judgment because of her continual practice of idolatry in many forms, including astrology, sorcery, divination and other occultism, all of which the Bible repeatedly condemns yet which are rampant in the United States today. Consider this comparison showing the strength of this movement: while The Late Great Planet Earth sold an astonishing 25 million copies, during almost the same period of time two books on astrology by Linda Goodman sold 60 million.
The Bible paints a clear picture of how great an abomination astrology is to God and yet how prevalent it remained among His chosen people in spite of repeated reproof. Jeremiah:19:13And the houses of Jerusalem, and the houses of the kings of Judah, shall be defiled as the place of Tophet, because of all the houses upon whose roofs they have burned incense unto all the host of heaven, and have poured out drink offerings unto other gods.
See All..., for example, indicate that it was a common practice for the kings and the people to engage in occultic rituals in honor of "the host of heaven...and other gods" upon the roofs of their houses throughout Israel. In Acts:7:42Then God turned, and gave them up to worship the host of heaven; as it is written in the book of the prophets, O ye house of Israel, have ye offered to me slain beasts and sacrifices by the space of forty years in the wilderness?
See All...; Deuteronomy:4:19And lest thou lift up thine eyes unto heaven, and when thou seest the sun, and the moon, and the stars, even all the host of heaven, shouldest be driven to worship them, and serve them, which the LORD thy God hath divided unto all nations under the whole heaven.
See All...; 17:3; 2 Kings:17:16And they left all the commandments of the LORD their God, and made them molten images, even two calves, and made a grove, and worshipped all the host of heaven, and served Baal.
See All...; 21:3-5; 23:4-5; 2 Chronicles:33:3-5  For he built again the high places which Hezekiah his father had broken down, and he reared up altars for Baalim, and made groves, and worshipped all the host of heaven, and served them.  Also he built altars in the house of the LORD, whereof the LORD had said, In Jerusalem shall my name be for ever.  And he built altars for all the host of heaven in the two courts of the house of the LORD.
See All...; Jeremiah:8:2And they shall spread them before the sun, and the moon, and all the host of heaven, whom they have loved, and whom they have served, and after whom they have walked, and whom they have sought, and whom they have worshipped: they shall not be gathered, nor be buried; they shall be for dung upon the face of the earth.
See All.... So evil are these abominations in God's eyes that anyone in Israel practicing astrology or any other form of idolatry/sorcery was to be put to death (Deut 17:2-7).
It is bad enough when the president of the most powerful nation in the world, a nation which has put men on the moon and boasts of its science and wisdom, is enslaved by superstitious practices, including astrology, which, as we demonstrate in America, science has disproved long ago. It is far worse, however, when a president who has openly professed faith in Christ, has called for national prayer and spoken out for biblical standards of morality (and from whom America so desperately needs sound spiritual leadership) sinks to the level of secretly seeking help and protection from astrology and lucky charms! It calls into question not only his leadership qualifications but also the Christian faith he has publicly declared and in secret denied.
We dare not view lightly what God has denounced and severely judged. Thousands of letters should go from Christians to the President, pointing out what the Bible has to say about astrology and lucky charms and other superstitious/occult practices that he has engaged in, and calling upon him to repent. Those Christian leaders who have access to Reagan must personally call upon him to repent. Their organization of and participation in prayer breakfasts, Washington for Jesus rallies and other similar events will be exposed as empty rhetoric if they do not now explain to the President his error and call upon him to make full, sincere and public confession, and to lead our nation to do likewise.


Audrey Watters is a writer who focuses on education technology. She has worked in the education field for almost twenty years: as a graduate student, college instructor, and program manager for an ed-tech non-profit.
Although she was two chapters into her Comparative Literature dissertation, she decided to abandon academia, and she now happily fulfills the one job recommended to her by a junior high aptitude test: freelance writer.
She has written for The Atlantic, Edutopia, Hybrid Pedagogy, MindShift, Inside Higher Ed, The School Library Journal, The Huffington Post, and elsewhere across the Web, in addition to her own website Hack Education.
She is the author of three books: The Monsters of Education Technology, The Revenge of the Monsters of Education Technology, and Claim Your Domain.
Rhona has been working as an educational developer in higher education for 20 years. She began her career as a psychology lecturer at the University of Plymouth and moved to the Open University Institute of Educational Technology. Rhona moved to the Oxford Centre for Staff and Learning Development in 2003 where she held positions as a Senior Lecturer and Principal Lecturer before becoming Head of the Centre in 2011 and Professor in 2013.
Rhona's interests are around developing online courses and uses of technology and encouraging pedagogic research. From 2005-2010 she directed a number of learner experience projects which led to the creation of ELESIG; a special interest group for those interested in evaluations of learners' experiences of e-learning.
A study of further education learners' experiences and expectations of the digital environment (FEDS) as part of Jisc's Digital Student CoDesign project.
Supporting learners in a digital age (SLiDA) funded by Jisc to create case studies of how institutions are supporting the development of learners for a digital age.
Learner Experiences of E-learning Support and Synthesis project funded by Jisc supporting the projects funded under the Learner Experiences of e-learning strand to synthesise and disseminate their work.
Review of the undergraduate experience of blended e-learning. A review of literature and practice undertaken for the Higher Education Academy.
Mike Feerick is the Founder & CEO of ALISON, a pioneer in the field of free online certified learning.
Launched in April 2007, ALISON is widely credited as the world's first MOOC (Massive Open Online Course), with a focus on providing free certified learning and skills training for the workplace. With 7 million learners' registered worldwide and 800,000 graduates of its 750 free courses, ALISON continues to lead a movement that is revolutionizing global access to education and employment opportunity.
In 2013 ALISON was awarded a World Innovation Summit for Education Award (WISE – Sponsored by the Qatar Foundation) for its impact on improving access to Education through innovation.
Mike was inspired to launch ALISON by Article 26 of the United National Human Rights Declaration which states that "education shall be free". He is an internationally recognised social entrepreneur receiving a Diploma Award from UNESCO for services to education (2010), an Ashoka Fellowship (2011), and an Arthur Guinness Social Fund Award (2012). He was a finalist in the World Economic Forum Social Entrepreneur of the Year 2016.
Mike is also the Ireland Reaching Out (Ireland XO), the Irish National Diaspora Programme with a goal to unify online the 80 million people of Irish descent worldwide.


The First Class Premium Manicure Edition by ZWILLING. Exclusive design and combination of materials in precious stainless steel and high-gloss deep black acrylic. Accurately, precision-manufactured!
Manicure instruments with special product features, e.g. scissors with micro-teeth and clippers with telescopic spring.
High-quality combination of materials in stainless steel and black acrylic.


text:
Published in Oncotarget V9I34, May 4, 2018
Changes of signal transductivity and robustness of gene regulatory network in the carcinogenesis of leukemic subtypes via microarray sample data
Cheng-Wei Li, Tzu-Ying Lai and Bor-Sen Chen _
Cheng-Wei Li1, Tzu-Ying Lai1 and Bor-Sen Chen1
1Laboratory of Control and Systems Biology, Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan
Bor-Sen Chen, email: [email protected]
Keywords: transductivity; network robustness; transductivity sensitivity; error sensitivity; basal sensitivity
Received: November 11, 2016 Accepted: April 11, 2018 Published: May 04, 2018
Mutation accumulation and epigenetic alterations in genes are important for carcinogenesis. Because leukemogenesis-related signal pathways have been investigated and microarray sample data have been produced in acute myeloid leukemia (AML), myelodysplastic syndromes (MDS) and normal cells, systems analysis in coupling pathways becomes possible.
Based on system modeling and identification, we could construct the coupling pathways and their associated gene regulatory networks using microarray sample data. By applying system theory to the estimated system model in coupling pathways, we can then obtain transductivity sensitivity, basal sensitivity and error sensitivity of each protein to identify the potential impact of genetic mutations, epigenetic alterations and the coupling of other pathways from the perspective of energy, respectively. By comparing the results in AML, MDS and normal cells, we investigated the potential critical genetic mutations and epigenetic alterations that activate or repress specific cellular functions to promote MDS or AML leukemogenesis. We suggested that epigenetic modification of β-catenin and signal integration of CSLs, AP-2α, STATs, c-Jun and β-catenin could contribute to cell proliferation at AML and MDS. Epigenetic regulation of ERK and genetic mutation of p53 could lead to the repressed apoptosis, cell cycle arrest and DNA repair in leukemic cells. Genetic mutation of JAK, epigenetic regulation of ERK, and signal integration of C/EBPα could result in the promotion of MDS cell differentiation. According to the results, we proposed three drugs, decitabine, genistein, and monorden for preventing AML leukemogenesis, while three drugs, decitabine, thalidomide, and geldanamycin, for preventing MDS leukemogenesis.

redpajama_set_name: RedPajamaCommonCrawl


Sometimes, bigger is better… For these situations, the 15W0v3 offers excellent excursion capability, linearity and an overall performance envelope that puts it right at the top of its price class. It features a very beefy 2.5 in. diameter voice coil and our patented Elevated Frame Cooling design for enhanced power handling and reliability.
The 15W0v3 is best used with amplifier power in the 150W – 500W range and is optimized to operate in a moderately sized 1.375 cu. ft. (38.9 l) sealed enclosure, or a 1.75 cu. ft. (49.6 l) ported enclosure.


For $2 million prize, university's Hummers will attempt to traverse 175 miles of desert in less than 10 hours. Agency will watch.
The Red Team from Carnegie Mellon University will field two robotic cars in the second DARPA Challenge, taking place in October. Under the contest, robotic cars will attempt to drive 175 miles through the desert in less than 10 hours. The winners, if any, will receive $2 million.
The contest draws student groups and well-funded university efforts alike. Caterpillar, Intel and Boeing are some of the sponsors of the Red Team, which will build their robots out of donated Hummers. Last year, the entry from CMU, one of the premier robotic research universities, only went 7.4 miles on the course, but that was farther than others made it. The Defense Advanced Research Projects Agency, which hopes to obtain a wide swath of ideas from these contests, will also hold challenges for aerial and other types of robots, the agency has said. Following time trials, DARPA will select 20 teams to participate.


As an authentic manufacturer brand, SKS-Germany can look back on a long history of "Made in Germany" products. In 1921, Karl Scheffer-Klute founded the company in Sundern, Germany (SKS= Scheffer-Klute Sundern).
The beginning of the pump production dates back to the year 1932. Therefore, in 2007 the 75th anniversary of this occasion was celebrated. The key break-through was marked by the first manufacturing of plastic pumps in 1956. Up until the beginning of the 90's, mass production for the OEM market dominated the product range. In peak years, up to 50,000 pumps were delivered per day. Today, high-quality mini pumps and floor pumps as well as special pumps for ambitious bikers dominate the pump portfolio.
By taking over the traditional British brand Bluemels in 1983, the entrance into the mudguard segment was made. In 1988 large-scale production of extruded mudguards began. Later on, after taking over the ESGE-production, these became –known as Chromoplastics- a worldwide reference for mudguards.
Bargain front quick release MTB mudguard.
Quick release rear MTB mudguard.
The Rolls Royce of mudguards!


Luxurious, rich and deeply moisturizing, this lotion offers a wonderful way to experience MIRACLE, the sparkling floral fragrance. Skin is instantly enveloped with silky moisture for lasting comfort. Perfect after the bath or shower for satiny-smooth, sensually scented skin.


EDIT: As reminded by ChemicalVengence, and referenced from section 2.1 of the flying spaghetti monster page on wikipedia, PIRATES DO NOT CAUSE GLOBAL WARMING! THEY HELP DECREASE GLOBAL WARMING! CARRY ON THEN!
I think the artist made a great art selection. All in all, it is a very solid piece of animation.
This was a good version of the song. Good job.
Are you ever going to make good on that deletion bit? Many, many of us hope you don't, as it's one of the most unique interpretations of the song and still one of the better animations for it.
Pirate the software! Complete 100 surveys to unlock keygen download!


A step-by-step guide for a post-relational database for .NET that provides you with better productivity and extensibility for data management. The article aims to help developers quickly evaluate this alternative solution for .NET data storage.
When it comes to data storage for .NET, there are several options in addition to the well-known ones such as SQL Server and MySQL. One of them is Matisse, a post-relational database by Matisse Software.
Why Matisse? It is the only SQL database that I know of that is extended with complete object capabilities and natively supports .NET. It features user-defined types, inheritance, polymorphism, and a simple data model with declarative constraints, etc. Over the last two years I have acquired practical knowledge of Matisse while working on several .NET projects that required complex data modeling.
While one can find press articles that provide high-level comparisons between mainstream relational databases and other products, I have not seen yet a simple step-by-step tutorial to help developers who wish to try their hand at next generation databases. I, therefore, resolved to publish a series of short articles to help address this void. Here is the first one.
To install Matisse, you need to run as a Windows Administrator. System requirements are Windows NT, 2000, or XP, 64MB of RAM, and 100 MB of disk space.
First, start the matisse70x.exe file, follow the instructions, and select "Typical/Full" as the type of setup. The installation will be completed within a couple of minutes. Then, start the matisseDotNet70x.exe to install the .NET interface. Choose the same directory for destination folder as the first installation (i.e., matisse70x.exe).
A lot of documents, including programming guides, an administration guide, and an installation guide, are also available at http://www.matisse.com/developers/documentation/.
1. You can browse classes, attributes, relationships, and SQL methods in a database just like any other vendors' tools. An interesting feature is that a class can show all its properties (i.e., attributes, relationships, and methods) including its superclasses' properties. So, when you write an SQL statement on a class, this feature is useful since you do not have to go back and forth between superclasses and subclasses to find out properties.
Here you see an advantage in database modeling with Matisse. You do not need any transformation of your model, and all the semantic information about associations between classes and their constraints are kept in the database schema. This is a big plus for maintenance and extension of the application.
In this article, I showed a quick and brief introduction to SQL programming with Matisse, which shows object features like inheritance and relationships.
I work with a software package called Caché from Intersystems and it too is a post-relational database. I love it and I definately think it's going to be the wave of the future in database computing!


Getting rid of a director or senior executive is not practically the same as terminating the employment of more junior employees, for two reasons: money and power. Company boards should anticipate this when appointing an executive, and make sure the contract is clear on how to manage both of these tricky matters. But often sending them off on gardening leave is the best solution.
Deon Visagie, partner at Webber Wentzel's Cape Town office says gardening leave is a term that is becoming more popular in South Africa these days, although it is more commonly used in other jurisdictions, mainly Europe.
A contract of employment normally requires a period of notice before termination. Where the contract is silent, then the statutory notice period is required before the contract of employment is terminated by either party. In executive employment contracts, notice periods of between 3 to 6 months are not uncommon.
Visagie advises that the notice provisions in executive employment contracts should provide that the employer may determine how the executive is to spend his time during the notice period, and companies generally rely on such provisions to effect the gardening leave.
The executive remains an employee of the company for the whole of the notice period, whether he is required to report for duty or not. Instead of saying that the executive was required by the board not to attend at the company during his three or more months of notice, which may be a negative for the executive from a reputational point of view, the parties normally agree to refer to that period as the executive being on gardening leave.
In reality, says Visagie, the executive is actually spending his notice period in accordance with the terms of his contract, which provides that the company can determine, subject to certain conditions that the executive not work during such notice.
Gardening leave should not be confused with annual leave, which is a legislative right and is normally also governed by the contract of employment between the parties. An employee, including executive employees, has a contractual and statutory right to be paid out any outstanding annual leave upon the termination of employment. So, in most cases gardening leave does not coincide and is not the same as taking annual leave, unless agreed to between the parties.


text:
"""
Handles all requests relating to consistency groups.
"""

import functools

from oslo_config import cfg
from oslo_log import log as logging
from oslo_utils import excutils
from oslo_utils import timeutils

from cinder.db import base
from cinder import exception
from cinder.i18n import _, _LE, _LW
import cinder.policy
from cinder import quota
from cinder.scheduler import rpcapi as scheduler_rpcapi
from cinder.volume import api as volume_api
from cinder.volume import rpcapi as volume_rpcapi
from cinder.volume import utils as vol_utils
from cinder.volume import volume_types

CONF = cfg.CONF

LOG = logging.getLogger(__name__)
CGQUOTAS = quota.CGQUOTAS
VALID_REMOVE_VOL_FROM_CG_STATUS = ('available', 'in-use',)

def wrap_check_policy(func):
    """Check policy corresponding to the wrapped methods prior to execution.

    This decorator requires the first 3 args of the wrapped function
    to be (self, context, consistencygroup)
    """
    @functools.wraps(func)
    def wrapped(self, context, target_obj, *args, **kwargs):
        check_policy(context, func.__name__, target_obj)
        return func(self, context, target_obj, *args, **kwargs)

    return wrapped

def check_policy(context, action, target_obj=None):
    target = {
        'project_id': context.project_id,
        'user_id': context.user_id,
    }
    target.update(target_obj or {})
    _action = 'consistencygroup:%s' % action
    cinder.policy.enforce(context, _action, target)

class API(base.Base):
    """API for interacting with the volume manager for consistency groups."""

    def __init__(self, db_driver=None):
        self.scheduler_rpcapi = scheduler_rpcapi.SchedulerAPI()
        self.volume_rpcapi = volume_rpcapi.VolumeAPI()
        self.availability_zone_names = ()
        self.volume_api = volume_api.API()

        super(API, self).__init__(db_driver)

    def _valid_availability_zone(self, availability_zone):
        if availability_zone in self.availability_zone_names:
            return True
        if CONF.storage_availability_zone == availability_zone:
            return True
        azs = self.volume_api.list_availability_zones()
        self.availability_zone_names = [az['name'] for az in azs]
        return availability_zone in self.availability_zone_names

    def _extract_availability_zone(self, availability_zone):
        if availability_zone is None:
            if CONF.default_availability_zone:
                availability_zone = CONF.default_availability_zone
            else:
                # For backwards compatibility use the storage_availability_zone
                availability_zone = CONF.storage_availability_zone

        valid = self._valid_availability_zone(availability_zone)
        if not valid:
            msg = _LW(
                "Availability zone '%s' is invalid") % (availability_zone)
            LOG.warning(msg)
            raise exception.InvalidInput(reason=msg)

        return availability_zone

    def create(self, context, name, description,
               cg_volume_types, availability_zone=None):

        check_policy(context, 'create')

        volume_type_list = None
        volume_type_list = cg_volume_types.split(',')

        req_volume_types = []
        req_volume_types = (self.db.volume_types_get_by_name_or_id(
            context, volume_type_list))

        req_volume_type_ids = ""
        for voltype in req_volume_types:
            req_volume_type_ids = (
                req_volume_type_ids + voltype.get('id') + ",")
        if len(req_volume_type_ids) == 0:
            req_volume_type_ids = None

        availability_zone = self._extract_availability_zone(availability_zone)

        options = {'user_id': context.user_id,
                   'project_id': context.project_id,
                   'availability_zone': availability_zone,
                   'status': "creating",
                   'name': name,
                   'description': description,
                   'volume_type_id': req_volume_type_ids}

        group = None
        try:
            group = self.db.consistencygroup_create(context, options)
        except Exception:
            with excutils.save_and_reraise_exception():
                LOG.error(_LE("Error occurred when creating consistency group"
                              " %s."), name)

        request_spec_list = []
        filter_properties_list = []
        for req_volume_type in req_volume_types:
            request_spec = {'volume_type': req_volume_type.copy(),
                            'consistencygroup_id': group['id']}
            filter_properties = {}
            request_spec_list.append(request_spec)
            filter_properties_list.append(filter_properties)

        # Update quota for consistencygroups
        self.update_quota(context, group['id'], 1)

        self._cast_create_consistencygroup(context, group['id'],
                                           request_spec_list,
                                           filter_properties_list)

        return group

    def create_from_src(self, context, name, description, cgsnapshot_id):
        check_policy(context, 'create')

        cgsnapshot = None
        orig_cg = None
        if cgsnapshot_id:
            cgsnapshot = self.db.cgsnapshot_get(context, cgsnapshot_id)
            if cgsnapshot:
                orig_cg = self.db.consistencygroup_get(
                    context,
                    cgsnapshot['consistencygroup_id'])

        options = {'user_id': context.user_id,
                   'project_id': context.project_id,
                   'status': "creating",
                   'name': name,
                   'description': description,
                   'cgsnapshot_id': cgsnapshot_id}

        if orig_cg:
            options['volume_type_id'] = orig_cg.get('volume_type_id')
            options['availability_zone'] = orig_cg.get('availability_zone')
            options['host'] = orig_cg.get('host')

        group = None
        try:
            group = self.db.consistencygroup_create(context, options)
        except Exception:
            with excutils.save_and_reraise_exception():
                LOG.error(_LE("Error occurred when creating consistency group"
                              " %(cg)s from cgsnapshot %(cgsnap)s."),
                          {'cg': name, 'cgsnap': cgsnapshot_id})

        # Update quota for consistencygroups
        self.update_quota(context, group['id'], 1)

        if not group['host']:
            msg = _("No host to create consistency group %s.") % group['id']
            LOG.error(msg)
            raise exception.InvalidConsistencyGroup(reason=msg)

        self._create_cg_from_cgsnapshot(context, group, cgsnapshot)

        return group

    def _create_cg_from_cgsnapshot(self, context, group, cgsnapshot):
        try:
            snapshots = self.db.snapshot_get_all_for_cgsnapshot(
                context, cgsnapshot['id'])

            if not snapshots:
                msg = _("Cgsnahost is empty. No consistency group "
                        "will be created.")
                raise exception.InvalidConsistencyGroup(reason=msg)

            for snapshot in snapshots:
                kwargs = {}
                kwargs['availability_zone'] = group.get('availability_zone')
                kwargs['cgsnapshot'] = cgsnapshot
                kwargs['consistencygroup'] = group
                kwargs['snapshot'] = snapshot
                volume_type_id = snapshot.get('volume_type_id')
                if volume_type_id:
                    kwargs['volume_type'] = volume_types.get_volume_type(
                        context, volume_type_id)

                # Since cgsnapshot is passed in, the following call will
                # create a db entry for the volume, but will not call the
                # volume manager to create a real volume in the backend yet.
                # If error happens, taskflow will handle rollback of quota
                # and removal of volume entry in the db.
                try:
                    self.volume_api.create(context,
                                           snapshot['volume_size'],
                                           None,
                                           None,
                                           **kwargs)
                except exception.CinderException:
                    with excutils.save_and_reraise_exception():
                        LOG.error(_LE("Error occurred when creating volume "
                                      "entry from snapshot in the process of "
                                      "creating consistency group %(group)s "
                                      "from cgsnapshot %(cgsnap)s."),
                                  {'group': group['id'],
                                   'cgsnap': cgsnapshot['id']})
        except Exception:
            with excutils.save_and_reraise_exception():
                try:
                    self.db.consistencygroup_destroy(context.elevated(),
                                                     group['id'])
                finally:
                    LOG.error(_LE("Error occurred when creating consistency "
                                  "group %(group)s from cgsnapshot "
                                  "%(cgsnap)s."),
                              {'group': group['id'],
                               'cgsnap': cgsnapshot['id']})

        volumes = self.db.volume_get_all_by_group(context,
                                                  group['id'])
        for vol in volumes:
            # Update the host field for the volume.
            self.db.volume_update(context, vol['id'],
                                  {'host': group.get('host')})

        self.volume_rpcapi.create_consistencygroup_from_src(
            context, group, group['host'], cgsnapshot)

    def _cast_create_consistencygroup(self, context, group_id,
                                      request_spec_list,
                                      filter_properties_list):

        try:
            for request_spec in request_spec_list:
                volume_type = request_spec.get('volume_type', None)
                volume_type_id = None
                if volume_type:
                    volume_type_id = volume_type.get('id', None)

                specs = {}
                if volume_type_id:
                    qos_specs = volume_types.get_volume_type_qos_specs(
                        volume_type_id)
                    specs = qos_specs['qos_specs']
                if not specs:
                    # to make sure we don't pass empty dict
                    specs = None

                volume_properties = {
                    'size': 0,  # Need to populate size for the scheduler
                    'user_id': context.user_id,
                    'project_id': context.project_id,
                    'status': 'creating',
                    'attach_status': 'detached',
                    'encryption_key_id': request_spec.get('encryption_key_id',
                                                          None),
                    'display_description': request_spec.get('description',
                                                            None),
                    'display_name': request_spec.get('name', None),
                    'volume_type_id': volume_type_id,
                }

                request_spec['volume_properties'] = volume_properties
                request_spec['qos_specs'] = specs

        except Exception:
            with excutils.save_and_reraise_exception():
                try:
                    self.db.consistencygroup_destroy(context, group_id)
                finally:
                    LOG.error(_LE("Error occurred when building "
                                  "request spec list for consistency group "
                                  "%s."), group_id)

        # Cast to the scheduler and let it handle whatever is needed
        # to select the target host for this group.
        self.scheduler_rpcapi.create_consistencygroup(
            context,
            CONF.volume_topic,
            group_id,
            request_spec_list=request_spec_list,
            filter_properties_list=filter_properties_list)

    def update_quota(self, context, group_id, num, project_id=None):
        reserve_opts = {'consistencygroups': num}
        try:
            reservations = CGQUOTAS.reserve(context,
                                            project_id=project_id,
                                            **reserve_opts)
            if reservations:
                CGQUOTAS.commit(context, reservations)
        except Exception:
            with excutils.save_and_reraise_exception():
                try:
                    self.db.consistencygroup_destroy(context.elevated(),
                                                     group_id)
                finally:
                    LOG.error(_LE("Failed to update quota for "
                                  "consistency group %s."), group_id)

    @wrap_check_policy
    def delete(self, context, group, force=False):
        if not group['host']:
            self.update_quota(context, group['id'], -1, group['project_id'])

            LOG.debug("No host for consistency group %s. Deleting from "
                      "the database.", group['id'])
            self.db.consistencygroup_destroy(context.elevated(), group['id'])

            return

        if not force and group['status'] not in ["available", "error"]:
            msg = _("Consistency group status must be available or error, "
                    "but current status is: %s") % group['status']
            raise exception.InvalidConsistencyGroup(reason=msg)

        cgsnaps = self.db.cgsnapshot_get_all_by_group(
            context.elevated(),
            group['id'])
        if cgsnaps:
            msg = _("Consistency group %s still has dependent "
                    "cgsnapshots.") % group['id']
            LOG.error(msg)
            raise exception.InvalidConsistencyGroup(reason=msg)

        volumes = self.db.volume_get_all_by_group(context.elevated(),
                                                  group['id'])

        if volumes and not force:
            msg = _("Consistency group %s still contains volumes. "
                    "The force flag is required to delete it.") % group['id']
            LOG.error(msg)
            raise exception.InvalidConsistencyGroup(reason=msg)

        for volume in volumes:
            if volume['attach_status'] == "attached":
                msg = _("Volume in consistency group %s is attached. "
                        "Need to detach first.") % group['id']
                LOG.error(msg)
                raise exception.InvalidConsistencyGroup(reason=msg)

            snapshots = self.db.snapshot_get_all_for_volume(context,
                                                            volume['id'])
            if snapshots:
                msg = _("Volume in consistency group still has "
                        "dependent snapshots.")
                LOG.error(msg)
                raise exception.InvalidConsistencyGroup(reason=msg)

        now = timeutils.utcnow()
        self.db.consistencygroup_update(context, group['id'],
                                        {'status': 'deleting',
                                         'terminated_at': now})

        self.volume_rpcapi.delete_consistencygroup(context, group)

    def update(self, context, group, name, description,
               add_volumes, remove_volumes):
        """Update consistency group."""
        if group['status'] not in ["available"]:
            msg = _("Consistency group status must be available, "
                    "but current status is: %s.") % group['status']
            raise exception.InvalidConsistencyGroup(reason=msg)

        add_volumes_list = []
        remove_volumes_list = []
        if add_volumes:
            add_volumes = add_volumes.strip(',')
            add_volumes_list = add_volumes.split(',')
        if remove_volumes:
            remove_volumes = remove_volumes.strip(',')
            remove_volumes_list = remove_volumes.split(',')

        invalid_uuids = []
        for uuid in add_volumes_list:
            if uuid in remove_volumes_list:
                invalid_uuids.append(uuid)
        if invalid_uuids:
            msg = _("UUIDs %s are in both add and remove volume "
                    "list.") % invalid_uuids
            raise exception.InvalidVolume(reason=msg)

        volumes = self.db.volume_get_all_by_group(context, group['id'])

        # Validate name.
        if not name or name == group['name']:
            name = None

        # Validate description.
        if not description or description == group['description']:
            description = None

        # Validate volumes in add_volumes and remove_volumes.
        add_volumes_new = ""
        remove_volumes_new = ""
        if add_volumes_list:
            add_volumes_new = self._validate_add_volumes(
                context, volumes, add_volumes_list, group)
        if remove_volumes_list:
            remove_volumes_new = self._validate_remove_volumes(
                volumes, remove_volumes_list, group)

        if (not name and not description and not add_volumes_new and
                not remove_volumes_new):
                msg = (_("Cannot update consistency group %(group_id)s "
                         "because no valid name, description, add_volumes, "
                         "or remove_volumes were provided.") %
                       {'group_id': group['id']})
                raise exception.InvalidConsistencyGroup(reason=msg)

        now = timeutils.utcnow()
        fields = {'updated_at': now}

        # Update name and description in db now. No need to
        # to send them over through an RPC call.
        if name:
            fields['name'] = name
        if description:
            fields['description'] = description
        if not add_volumes_new and not remove_volumes_new:
            # Only update name or description. Set status to available.
            fields['status'] = 'available'
        else:
            fields['status'] = 'updating'

        self.db.consistencygroup_update(context, group['id'], fields)

        # Do an RPC call only if the update request includes
        # adding/removing volumes. add_volumes_new and remove_volumes_new
        # are strings of volume UUIDs separated by commas with no spaces
        # in between.
        if add_volumes_new or remove_volumes_new:
            self.volume_rpcapi.update_consistencygroup(
                context, group,
                add_volumes=add_volumes_new,
                remove_volumes=remove_volumes_new)

    def _validate_remove_volumes(self, volumes, remove_volumes_list, group):
        # Validate volumes in remove_volumes.
        remove_volumes_new = ""
        for volume in volumes:
            if volume['id'] in remove_volumes_list:
                if volume['status'] not in VALID_REMOVE_VOL_FROM_CG_STATUS:
                    msg = (_("Cannot remove volume %(volume_id)s from "
                             "consistency group %(group_id)s because volume "
                             "is in an invalid state: %(status)s. Valid "
                             "states are: %(valid)s.") %
                           {'volume_id': volume['id'],
                            'group_id': group['id'],
                            'status': volume['status'],
                            'valid': VALID_REMOVE_VOL_FROM_CG_STATUS})
                    raise exception.InvalidVolume(reason=msg)
                # Volume currently in CG. It will be removed from CG.
                if remove_volumes_new:
                    remove_volumes_new += ","
                remove_volumes_new += volume['id']

        for rem_vol in remove_volumes_list:
            if rem_vol not in remove_volumes_new:
                msg = (_("Cannot remove volume %(volume_id)s from "
                         "consistency group %(group_id)s because it "
                         "is not in the group.") %
                       {'volume_id': rem_vol,
                        'group_id': group['id']})
                raise exception.InvalidVolume(reason=msg)

        return remove_volumes_new

    def _validate_add_volumes(self, context, volumes, add_volumes_list, group):
        add_volumes_new = ""
        for volume in volumes:
            if volume['id'] in add_volumes_list:
                # Volume already in CG. Remove from add_volumes.
                add_volumes_list.remove(volume['id'])

        for add_vol in add_volumes_list:
            try:
                add_vol_ref = self.db.volume_get(context, add_vol)
            except exception.VolumeNotFound:
                msg = (_("Cannot add volume %(volume_id)s to consistency "
                         "group %(group_id)s because volume cannot be "
                         "found.") %
                       {'volume_id': add_vol,
                        'group_id': group['id']})
                raise exception.InvalidVolume(reason=msg)
            if add_vol_ref:
                add_vol_type_id = add_vol_ref.get('volume_type_id', None)
                if not add_vol_type_id:
                    msg = (_("Cannot add volume %(volume_id)s to consistency "
                             "group %(group_id)s because it has no volume "
                             "type.") %
                           {'volume_id': add_vol_ref['id'],
                            'group_id': group['id']})
                    raise exception.InvalidVolume(reason=msg)
                if add_vol_type_id not in group['volume_type_id']:
                    msg = (_("Cannot add volume %(volume_id)s to consistency "
                             "group %(group_id)s because volume type "
                             "%(volume_type)s is not supported by the "
                             "group.") %
                           {'volume_id': add_vol_ref['id'],
                            'group_id': group['id'],
                            'volume_type': add_vol_type_id})
                    raise exception.InvalidVolume(reason=msg)
                if (add_vol_ref['status'] not in
                        VALID_REMOVE_VOL_FROM_CG_STATUS):
                    msg = (_("Cannot add volume %(volume_id)s to consistency "
                             "group %(group_id)s because volume is in an "
                             "invalid state: %(status)s. Valid states are: "
                             "%(valid)s.") %
                           {'volume_id': add_vol_ref['id'],
                            'group_id': group['id'],
                            'status': add_vol_ref['status'],
                            'valid': VALID_REMOVE_VOL_FROM_CG_STATUS})
                    raise exception.InvalidVolume(reason=msg)

                # group['host'] and add_vol_ref['host'] are in this format:
                # 'host@backend#pool'. Extract host (host@backend) before
                # doing comparison.
                vol_host = vol_utils.extract_host(add_vol_ref['host'])
                group_host = vol_utils.extract_host(group['host'])
                if group_host != vol_host:
                    raise exception.InvalidVolume(
                        reason=_("Volume is not local to this node."))

                # Volume exists. It will be added to CG.
                if add_volumes_new:
                    add_volumes_new += ","
                add_volumes_new += add_vol_ref['id']

            else:
                msg = (_("Cannot add volume %(volume_id)s to consistency "
                         "group %(group_id)s because volume does not exist.") %
                       {'volume_id': add_vol_ref['id'],
                        'group_id': group['id']})
                raise exception.InvalidVolume(reason=msg)

        return add_volumes_new

    def get(self, context, group_id):
        rv = self.db.consistencygroup_get(context, group_id)
        group = dict(rv.iteritems())
        check_policy(context, 'get', group)
        return group

    def get_all(self, context, marker=None, limit=None, sort_key='created_at',
                sort_dir='desc', filters=None):
        check_policy(context, 'get_all')
        if filters is None:
            filters = {}

        try:
            if limit is not None:
                limit = int(limit)
                if limit < 0:
                    msg = _('limit param must be positive')
                    raise exception.InvalidInput(reason=msg)
        except ValueError:
            msg = _('limit param must be an integer')
            raise exception.InvalidInput(reason=msg)

        if filters:
            LOG.debug("Searching by: %s", filters)

        if (context.is_admin and 'all_tenants' in filters):
            # Need to remove all_tenants to pass the filtering below.
            del filters['all_tenants']
            groups = self.db.consistencygroup_get_all(context)
        else:
            groups = self.db.consistencygroup_get_all_by_project(
                context,
                context.project_id)

        return groups

    def create_cgsnapshot(self, context,
                          group, name,
                          description):
        return self._create_cgsnapshot(context, group, name, description)

    def _create_cgsnapshot(self, context,
                           group, name, description):
        options = {'consistencygroup_id': group['id'],
                   'user_id': context.user_id,
                   'project_id': context.project_id,
                   'status': "creating",
                   'name': name,
                   'description': description}

        try:
            cgsnapshot = self.db.cgsnapshot_create(context, options)
            cgsnapshot_id = cgsnapshot['id']

            volumes = self.db.volume_get_all_by_group(
                context.elevated(),
                cgsnapshot['consistencygroup_id'])

            if not volumes:
                msg = _("Consistency group is empty. No cgsnapshot "
                        "will be created.")
                raise exception.InvalidConsistencyGroup(reason=msg)

            snap_name = cgsnapshot['name']
            snap_desc = cgsnapshot['description']
            self.volume_api.create_snapshots_in_db(
                context, volumes, snap_name, snap_desc, True, cgsnapshot_id)

        except Exception:
            with excutils.save_and_reraise_exception():
                try:
                    self.db.cgsnapshot_destroy(context, cgsnapshot_id)
                finally:
                    LOG.error(_LE("Error occurred when creating cgsnapshot"
                                  " %s."), cgsnapshot_id)

        self.volume_rpcapi.create_cgsnapshot(context, group, cgsnapshot)

        return cgsnapshot

    def delete_cgsnapshot(self, context, cgsnapshot, force=False):
        if cgsnapshot['status'] not in ["available", "error"]:
            msg = _("Cgsnapshot status must be available or error")
            raise exception.InvalidCgSnapshot(reason=msg)
        self.db.cgsnapshot_update(context, cgsnapshot['id'],
                                  {'status': 'deleting'})
        group = self.db.consistencygroup_get(
            context,
            cgsnapshot['consistencygroup_id'])
        self.volume_rpcapi.delete_cgsnapshot(context.elevated(), cgsnapshot,
                                             group['host'])

    def update_cgsnapshot(self, context, cgsnapshot, fields):
        self.db.cgsnapshot_update(context, cgsnapshot['id'], fields)

    def get_cgsnapshot(self, context, cgsnapshot_id):
        check_policy(context, 'get_cgsnapshot')
        rv = self.db.cgsnapshot_get(context, cgsnapshot_id)
        return dict(rv.iteritems())

    def get_all_cgsnapshots(self, context, search_opts=None):
        check_policy(context, 'get_all_cgsnapshots')

        search_opts = search_opts or {}

        if (context.is_admin and 'all_tenants' in search_opts):
            # Need to remove all_tenants to pass the filtering below.
            del search_opts['all_tenants']
            cgsnapshots = self.db.cgsnapshot_get_all(context)
        else:
            cgsnapshots = self.db.cgsnapshot_get_all_by_project(
                context.elevated(), context.project_id)

        if search_opts:
            LOG.debug("Searching by: %s", search_opts)

            results = []
            not_found = object()
            for cgsnapshot in cgsnapshots:
                for opt, value in search_opts.iteritems():
                    if cgsnapshot.get(opt, not_found) != value:
                        break
                else:
                    results.append(cgsnapshot)
            cgsnapshots = results
        return cgsnapshots

redpajama_set_name: RedPajamaGithub


text:
Jimmy Gobble #41
Jimmy Gobble
Summary Stats Awards Shop
Career Regular Season
247 22-23 5.29 435.2 285 1.49
2 .000 0 0 0 .000
Jimmy Gobble Bio
Fullname: Billy James Gobble
Born: 7/19/1981 in Bristol, TN
Draft: 1999, Kansas City Royals, Round: C, Overall Pick: 43
High School: John S. Battle, Bristol, VA
Debut: 8/03/2003
Follow mlb
View More Bio Info +
Billy James Gobble
Full name is Billy James Gobble...married to Julie...the couple has two sons, Porter James and Palmer Andrew...graduated from John Battle (Va.) High, 1999...was the 43rd overall selection by Kansas City in sandwich round of the 1999 June Draft.
Began Spring Training in Major League camp with Kansas City before being released on 3/18...signed with Texas for the remainder of Spring Training but did not make the Major League roster out of camp and was again released...signed with the White Sox and reported to the club's Triple-A Charlotte affiliate...made 11 appearances for Charlotte before being called up to the Majors on 5/11...spent nearly two months on the Major League roster before being released on 7/15 and became a free agent...made 12 appearances for the White Sox, with no record and a 7.50 ERA (12.0 ip, 10 er)...9 of his 12 appearances were scoreless, though he allowed 6 runs in one appearance, and 3 runs in another appearance...made 7 consecutive scoreless appearances from 5/25-6/14 for the White sox before allowing 3 runs 6/24 vs. LAD...made only two appearances from 6/15-7/8, the day he was designated for assignment...made 11 appearances with Triple-A Charlotte before the call-up to the Majors...owned an 0-1 record with one save and a 5.25 ERA (12.0 ip, 7 er)...had 19 strikeouts in 12.0 innings pitched for Charlotte...allowed runs in just 3 of his 11 appearances...opponents hit just .174 (8-for-46) against him in Triple-A...did not catch on with another organization after being granted his release by Chicago in July.
Made the Opening Day roster for the fourth time in his career and third season in a row...held left-handed batters to a .200 (13-for-65) average, but right-handers hit .382 (26-for-68) with four home runs against him...began the season with 6 consecutive scoreless and hitless outings, covering 3.2 innings...walked 1 and struck out 5...he earned his fourth career save by retiring the final 2 hitters on April 9 to closeout Kansas City's 4-0 win over the Yankees...had the roughest outing of his career on July 21 vs. Detroit, allowing 10 runs on 7 hits and 4 walks in 1.0 inning of relief...it was the most runs ever scored off a KC relief pitcher...posted the highest ERA in baseball among pitchers with at least 30 innings pitched...his ERA was the third-highest among Royals pitchers ever (min. 30 IP), trailing only Scott Elarton, who posted a 10.46 ERA in 37 innings in 2007, and Dan Reichert, who had a 9.08 ERA in 1999...placed on the 15-day D.L. on July 22 with low back tightness...made 8 appearances (including 4 starts) on a rehab assignment with Omaha before being reinstated from the D.L. on September 2 after missing 35 Major League games...was far more effective in September after returning from the D.L., tossing 8 scoreless outings covering 7.0 innings.
Made the Opening Day roster for the 3rd time in his career and 2nd season in a row...had the best season of his career, going 4-1 with 1 save and a 3.02 ERA (53.2 IP, 56 H, 18 ER) in 74 appearances...Set a career high with 74 appearances, ranking fourth all-time in Royals history behind Dan Quisenberry (84 in 1985 and 75 in 1980) and Jason Grimsley (76 in 2003)...posted the most appearances by a lefty in franchise history...His 74 appearances placed him tied for fifth in the A.L...Of his 74 outings, he tossed less than 1 innings in 41 of them...he did last an inning or more in 9 of his final 17 appearances including equaling his season high (5th time) with 1.2 innings pitched on Sept. 10 vs. Minnesota...Held left-handed hitters to a .241 (26-for-108) average and struck out 40 lefties in 108 at bats as opposed to 10 righties in 94 at bats...Pitched extremely well at home, recording a 1-1 record with a 2.33 ERA (27 IP, 26 H, 7 ER) in 38 games...was 3-0 with 1 save and a 3.71 ERA (26.2 IP, 30 H, 11 ER) in 36 road appearances...Made 14 of his 74 appearances against the left-handed heavy Cleveland Indians, posting a 2.61 ERA (10.1 IP, 6 H, 3 ER, 3 BB, 12 SO)...Kept his ERA below 3.00 until allowing 2 runs in 0.2 innings on July 25 vs. the Yankees...Had 4 separate occurences where he posted at least 5 straight outings not allowing an earned run including a season-high 9 consecutive outings from Sept. 7-28 (8.1 IP, 4 H, 1 BB, 10 SO)...Won 3 decisions in 4 relief outings from May 9-16...all of the wins came against the Oakland Athletics...Picked up his third career save on June 24 at Milwaukee...2 of his 3 career saves have come against the Brewers (also June 25, 2006)...Pitched well down the stretch, posting a 1.46 ERA (12.1 IP, 8 H, 2 ER, 3 BB, 14 SO) in his final 14 outings of the season.
Spent his 1st full season at the Major League level and made a career-high 60 appearances with a 4-6 record and a 5.14 ERA (84.0 IP, 48 ER)...led Royals pitchers with 80 strikeouts...Allowed only 12 of 48 (25 percent) inherited runners to score on the season...Averaged 8.57 strikeouts per 9 innings after averaging only 4.18 strikeouts per 9 innings (254.1 IP, 118 SO) in his career prior to the season...Opened the season as reliever, but made 6 starts for the Royals...was 1-3 with a 6.15 ERA (26.1 IP, 35 H, 18 ER) as a starter...had 11 walks, compared to 23 strikeouts as a starter...5 of his 6 starts came at Kauffman Stadium...Was named the Royals Pitcher of the Month for May after leading the Royals with a 3.00 ERA and striking out 13 batters in 15.0 innings...Turned in 8-straight scoreless outings (11.2 IP, 3 H, 3 BB, 9 SO) from April 16-May 6...His 1st start came as a spot start on May 24 vs. Detroit...allowed just 3 hits and 1 earned run in 4.0 innings of work...Returned to the bullpen and compiled a 2-0 record with a 2.16 ERA (16.2 IP, 4 ER) in 14 appearances May 26-June 30...Opened the season by allowing 8 ER in his 1st 4 outings (3.0 IP) for a 24.00 ERA...rebounded to record a 2.09 ERA (38.2 IP, 9 ER) over his next 27 outings through June 30...Returned to the rotation on July 4 after making 14 relief appearances between starts....earned a 7-2 win vs. Minnesota after throwing 5.0 innings and allowing 5 hits and 2 runs...Earned his 1st professional save June 25 vs. Milwaukee by entering the game with KC leading 3-0 and closing out the fi nal 1.1 innings in the team's eventual 6-0 win...Was charged with losses in back-to-back starts vs. Toronto on July 9 and at Detroit on July 15...lasted only 3.1 innings (8 H, 5 ER) vs. Toronto and 5.0 innings at Detroit (8 H, 4 ER)...Threw 3.0 innings of relief vs. Cleveland on Aug. 24 and was charged with an 8-4 loss despite giving up just 1 hit and 1 unearned run...Earned a win in the last game of the season on Oct. 1 at Detroit, tossing 1.1 scoreless innings in the Royals 10-8, 12-inning win...escaped a bases-loaded jam in the 11th...the win prevented the Tigers from winning the A.L. Central division title.
Made a career-high 28 appearances, surpassing his previous high total of 25 set in 2004...went 1-1 with a 5.70 ERA in 53.2 innings...made 24 relief appearances after making just 1 previous career relief appearance...Began the year at Omaha (AAA)...was 2-7 with a 6.63 ERA (58.1 IP, 76 H, 43 ER) in 12 starts for the O-Royals at the time of his promotion...Recalled from Omaha on June 20...tossed a scoreless inning that night at Chicago...Was 0-1 with a 4.67 ERA (17.1 IP, 22 H, 9 ER) in his 4 starts...lasted a season-high 5.1 innings vs. Detroit on Sept. 21...posted a 1-0 record and a 6.19 ERA (36.1 IP, 25 ER) out of the bullpen...Struggled at Kauffman Stadium, posting a 9.14 ERA (21.2 IP, 32 H, 22 ER) in 10 appearances, compared to a 3.38 ERA (32.0 IP, 32 H, 12 ER) in 18 road games...was impressive in 7 day games, logging a 2.65 ERA (17.0 IP, 14 H, 5 ER), compared to a 7.12 ERA (36.2 IP, 29 ER) in night games...Allowed 8 earned runs in 2.0 innings vs. Oakland on Aug. 6...had a 4.53 ERA (51.2 IP, 26 ER) in his other 27 outings...Turned in 7 consecutive scoreless road outings from July 31 at Tampa Bay to Aug. 28 at New York (9.1 IP, 5 H, 5 BB, 4 SO)...Struck out the side in the 6th inning on June 24 at Colorado for the 1st time in his career...Earned his only win of the season at Oakland on Aug. 21 in KC's 5-4, 12-inning victory after tossing 3.0 perfect innings...KC rallied from a 3-0 deficit to score 4 in the 8th and 1 in the 12th.
Had his most productive season at the big league level, going 9-8 with a 5.35 ERA in 25 games (24 starts)..Was tied for the team lead in wins (also Darrell May) and was the only Royals pitcher to post a winning record for the season...Was 3-0 in his final 5 starts with a 4.01 ERA (33.2 IP, 29 H, 15 ER)...Had the fewest strikeouts (49) in club history for a pitcher with 20 or more starts, eclipsing the mark of 53 shared by Al Fitzmorris (1974) and Paul Splittorff (1980)...Was 6-3 in road games with a 5.67 ERA...won his last 3 road starts and was 5-1 in his last 7 starts on the road...pitched in 8 of KC's 25 road wins...Took a no decision in his 2004 debut, a 3-1 Royals win over Cleveland on April 9...allowed just 1 hit with 2 walks and 2 strikeouts over 6.0 scoreless innings...Was 1-0 and allowed just 3 hits and 1 ER in 2 starts vs. Cleveland for a 0.69 ERA...Collected his 1st win of the season in KC's 5-3 victory over Texas on April 28... allowed 2 runs in 5.1 innings before leaving the game with muscle cramps...Pitched the best game of his big league career at Toronto on May 3, but had to settle for a no decision in KC's 10-inning, 3-2 win...retired the 1st 16 batters of the game before Orlando Hudson reached on a throwing error by Joe Randa...Dave Berg then singled to break up the no-hit bid...Gobble pitched 8.0 scoreless innings before allowing 2 runs in the 9th...Was selected as Royals Pitcher of the Month for April after going 1-0 with a 2.82 ERA in 4 games (3 starts)...Was optioned to Omaha on July 29 and was recalled on Aug. 29...Collected his 1st career complete game at Minnesota on Sept. 5 (9.0 IP, 6 H, 3 ER) in the 12-3 win, snapping a 9-game losing streak at the Metrodome.
Saw his 1st big league action, going 4-5 with a 4.61 ERA in 9 starts...allowed 27 ER and 56 hits in 52.2 innings...Was called up from Wichita on Aug. 2...made his 1st Major League start on Aug. 3 vs. Tampa Bay... earned his 1st Major League victory in the Royals 2-0 win over the Devil Rays by pitching 6.0 shutout innings and allowing 6 hits and 3 strikeouts...Became the 1st Royals rookie to win his 1st Major League start since Glendon Rusch on April 6, 1997 at Minnesota...became the 1st Royals rookie since Derek Botelho on July 18, 1982 to win his Major League debut as part of a shutout...Earned his 2nd-straight Major League victory on Aug. 9 at Tampa Bay (6.1 IP, 7 H, 1 ER, 3 SO)...Became the 1st KC rookie to win his 1st 2 big league starts since Glendon Rusch in 1997...et a club record for consecutive scoreless innings by a starter to open a career (12.0 IP)...Was charged with the Royals 9-2 loss to the Twins on Aug. 15 (3.0 IP, 8 H, 5 ER)...was his 1st Major League loss...Was optioned to Omaha (AAA) on Aug. 30 and recalled on Sept. 2 without making a minor league appearance.
Made just 13 starts for Wichita (AA) in 2002 after suffering from a left groin strain...Went 5-7, allowing 26 earned runs in 69.1 innings of work for a 3.38 ERA...Compiled a 2-3 mark and a 1.42 ERA (31.2 IP, 5 ER) at home, compared to a 3-4 record and a 5.02 ERA (37.1 IP, 21 ER) on the road.
Was named the Royals Minor League Pitcher of the Year in 2001...Was 2nd in ERA (2.55) and 3rd in strikeouts (154) in the Carolina League in 2001...also ranked 3rd in starts (27) and 4th in walks per 9 innings (1.66)...Posted a 10-6 mark for Wilmington (A) and a 2.55 ERA in 27 starts...tossed 162.1 innings, recording 154 strikeouts...Was named to the SportsTicker All-Teen Team...Blue Rocks had a 17-10 record when he started in 2001, while scoring only 4 runs in his 6 losses...Had a club-high 15 strikeouts on Sept. 6 vs. Frederick in the Blue Rocks playoff clinching victory.
Posted a 12-10 record and a 3.66 ERA for Charleston (A)...walked just 34 batters and struck out 115 in 145.0 innings of work...Led the South Atlantic League with 2 shutouts in 2000...finished 4th in complete games and 5th in wins...Won 5 straight starts with a 2.12 ERA from June 29-July 20 pitching 34.0 innings with 8 earned runs.
Saw action in 4 games with the Gulf Coast Royals, including 1 start...allowed 2 runs in 6.2 innings for a 2.70 ERA...did not figure in a decision.
Career Regular Season 2 0 0 0 0 0 .000 .000 .000
Career Regular Season 22 23 5.29 247 43 4 435.2 285 1.49
TEX Post-Season All-Star
2003 Wichita Wranglers TEX
2004 24 23rd in AL
2007 74 5th in AL
April 4, 2013 Rockies Extended Spring Training placed LHP Jimmy Gobble on the reserve list.
June 3, 2010 LHP Jimmy Gobble assigned to Rockies Extended Spring Training from Colorado Springs Sky Sox.
April 20, 2010 Jimmy Gobble roster status changed by Colorado Springs Sky Sox.
April 16, 2010 LHP Jimmy Gobble assigned to Colorado Springs Sky Sox from Colorado Rockies.
January 28, 2010 Colorado Rockies signed free agent LHP Jimmy Gobble to a minor league contract and invited him to spring training.
July 8, 2009 Chicago White Sox designated Jimmy Gobble for assignment.
May 11, 2009 Chicago White Sox selected the contract of LHP Jimmy Gobble from Charlotte Knights.


text:
Question: Why steam is hotter than boiling water?
Is steam hotter than the boiling water?
Is steam hotter than fire?
Can water steam without boiling?
What is the temperature of steam of boiling water?
Why are steam burns so bad?
Why are steam burns worse?
What is the highest temperature of steam?
Can we see steam?
Is Steam the same as water vapor?
Why is there steam in the shower?
How hot is steam cleaner?
Why is steam at 100 C more dangerous than boiling water at the same temperature?
What produces more severe burns boiling water or steam?
Steam occurs when water goes above 212 degrees Fahrenheit, which is hotter than water when it is at its stable point. … As a result, burns from steam that is coming from a pot of boiling water because it is at a higher temperature than the water itself.
The steam is no hotter than the water but it contains more usable heat energy per gram, and it can release that heat as it encounters a cooler medium and makes the phase-change back to water.
Water in a strong, closed, pressurized container can be as hot as fire or hotter. … Water can be heated to 374C (705F) when under 21.7MPa of pressure and still be a liquid. A cool flame is around 400C. However water as a gas (Steam) can be over a 1000C.
That means, to produce steam, you need to boil water, so it changes its phase from liquid to gas. … However, scientists are proving that it is possible to produce steam from water without boiling it – simply by supplying the latent heat necessary to change the phase.
IT IS INTERESTING: Does water boil faster on high heat?
Essentially, boiling water at 100 degrees celcius, becomes steam at 100 degrees celcius when it overcomes the latent heat of vaporization.
Summary: Even if the wound looks superficially harmless, steam burns must be cooled persistently. Researchers have now been able to show for the first time how hot steam achieves its vicious effect: it penetrates the upper skin layer and can cause severe burns in the lower skin layers — initially almost invisible.
The reason is that steam that burns your skin also goes through a phase change. … Therefore, the energy from the phase change and the energy from the heat all goes into your skin at once, leading to severe burns. Boiling water also transfers heat at the moment of contact, and it also decreases in temperature.
generally at the critical point of the vapor dome the max temp and pressure that a steam can have is 375 degree celcius…. above this temp steam is generally called superheated steam……the temp used in steam powerplants using superheated steam can rise the temp to as high as 600 degrees with increased pressure too.
Steam is an invisible gas, unlike water vapor, which appears as a mist or fog. … At first you don't see anything; that's the steam. And then after the steam are the small white billows of smoke, which is actually the steam condensing back into water vapor (due to contact with the air).
IT IS INTERESTING: Question: How long does it take for isopropyl alcohol to boil?
All steam is water vapor, but not all water vapor is steam.
Water vapor just means the gas form of water. Water is a molecule, not specifically a liquid.
When steam appears in the bathroom, it originates from the showerhead. This is because when the water that comes from the showerhead is warmer than the air in the room. … While there are instances where evaporation causes steam in the bathroom, steam in the bathroom is usually as a result of condensation.
Residential units heat water up to temperatures between 150° and 300° Fahrenheit (66-149° Celsius). For example, Reliable steam cleaners typically have a steam tip temperature of 245° F. The hot steam kills dust mites, mold, mildew, viruses, and other allergens on contact as well as loosening most dirt and grime.
Steam will produce more severe burns than boiling of water because steam has more heat energy than water due to its latent heat of vaporisation and additionally latent heat of condensation.
Steam causes more severe burns.
So, when steam falls on skin and condenses to produce water it gives out 22.5 x 105 J/kg more heat than boiling water at the same temperature. Steam has more energy than boiling water. Therefore, burns produced by steam are more severe than those produced by boiling water.
IT IS INTERESTING: Frequent question: How long do I boil artichokes for?
Quick Answer: How long do cooked wheat berries last in the fridge?
You asked: Should you freeze baked ziti before or after baking?
Can you finish cooking a turkey later?
Frequent question: How do you properly cook chicken?
Best answer: Can you keep oil after frying fish?
Question: How do you fry two eggs?
You asked: Is it safe to eat fried chicken with blood?


text:
Q: Spring Security: hasRole not working & AuthenticaionPrincipal is null I have a PUT mapped controller method which should be restricted to users with ROLE_BUYER role.
However during testing it is returing 200 OK to users without that role.
The controller method is getting called but both the @AuthenticationPrincipal and HttpServletRequest.getRemoteUser() are null.
The controller:
@PutMapping("{bookId}/borrow/{userId}")
public boolean borrowBook(@PathVariable("bookId") long bookId, @PathVariable("userId") long userId, @AuthenticationPrincipal(errorOnInvalidType=true) UserDetails user) {
    return bookService.borrowBook(bookId,userId);
}

The Security Configuration:
@EnableWebSecurity
public class LibrarySecurityConfiguration extends WebSecurityConfigurerAdapter {

    @Override
    public void configure(HttpSecurity http) throws Exception {
        http.authorizeRequests()
            .mvcMatchers(HttpMethod.PUT,"/**").hasRole("LIBRARIAN")
            .mvcMatchers(HttpMethod.GET,"/**").permitAll()
            .and().csrf().disable();
    }
}

The test method:
@Test
public void borrowBookwithNormalUser() throws Exception {

    var userId = gilbert.getId();
    assertThat(gilbert.getAuthorities().contains(new SimpleGrantedAuthority("ROLE_LIBRARIAN"))).isFalse();

    mockMvc.perform(
        MockMvcRequestBuilders
            .put("/books/2/borrow/"+userId)
            .with(SecurityMockMvcRequestPostProcessors.user(gilbert))
    ).andExpect(
        MockMvcResultMatchers.status().isForbidden()
    );

}

Here is the test setup :
@SpringBootTest
public class BookControllerTests {

    @Autowired
    private WebApplicationContext context;

    @Autowired
    private UserDetailsService uds;

    private MockMvc mockMvc;
    private LibraryUser gilbert;

    @BeforeEach
    public void setup() {
        mockMvc = MockMvcBuilders
            .webAppContextSetup(context)
            .build();
        gilbert = (LibraryUser)uds.loadUserByUsername("gilbert");
    }

LibraryUser is an entity that implements UserDetails.
@Entity
public class LibraryUser implements Serializable, UserDetails {

   @Id
   private long id;

   @Column(unique=true)
   private String username

   private String password;

   private boolean library = false;

   public Collection<? extends GrantedAuthority> getAuthorities() {
       var res = new ArrayList<GrantedAuthority>();
       res.add(new SimpleGrantedAuthority("ROLE_USER"));
       if(librarian) {
           res.add(new SimpleGrantedAuthority("ROLE_LIBRARIAN"));
       }
       return res;
   }
}

Is it a problem with the WebSecurityConfigurerAdapter or the test itself ?

A: Thanks to @Toerktumlare, I found out that the problem was in my test setup.
It was missing .apply(SecurityMockMvcConfigurers.springSecurity()). Here is the complete test setup:
@BeforeEach
public void setup() {
    mockMvc = MockMvcBuilders
        .webAppContextSetup(context)
        .apply(SecurityMockMvcConfigurers.springSecurity())
        .build();
    gilbert = (LibraryUser)uds.loadUserByUsername("gilbert");
}

PS: Not sure, if this should be an edit/comment/answer.

redpajama_set_name: RedPajamaStackExchange


One of the most pervasive influences of land-use activities on stream ecosystems is an increase in sediment load.
Cutthroat trout lay their eggs in streambed gravel. When fine sediment occupies the space between this gravel, success of cutthroat trout reproduction decreases.
Sediment and the pollution it carries is also extremely detrimental to the aquatic insects that use the streambed for their remarkably complex life stages.


For the last decade people close to Microsoft have watched, often with consternation, as the software giant sat out the first phase of several major sea changes in the technology world and then played a sometimes unconvincing and at times underwhelming game of catch-up. Even with the cloud, Microsoft was not the first out of the blocks with a public offering, but sometimes not going first can have huge benefits because it lets you get a sense of the market.
Such is the case with Microsoft's cloud platform, at least in terms of application development, as it has navigated first by matching and then surrounding Amazon and other cloud providers. In fact, there is so much in Azure for developers that it makes it hard for other cloud platforms to keep up. Ian Culling, CTO of VersionOne pointed this out, saying that "What Microsoft is doing with Azure seems counter to their behavior and philosophy of the past—not just tolerating but embracing open source and other technologies, for example.
"It is also very encouraging for the classic/career Microsoft-stack developer to get outside the bounds of their MSDN Subscription and get the exposure, knowledge and skills to remain relevant in an increasingly polyglot development experience." This last part is critical to understanding Azure today. Microsoft provides Linux images in the Virtual Machine gallery, provides tools for developers using non-Microsoft technologies, and has been embracing open source of late.
Azure is arguably the most dynamic product offering Microsoft has ever produced. Today, no more than a few weeks can pass without an announcement of a new capability or improvement, often in batches. A quick look at Scott Guthrie's blog shows this track record clearly.
Before his promotion to Executive Vice President, he was always the first place to find news about improvements and added features. We will see if that continues now that he has moved up the line, but it is unlikely he will shy away from announcing the most interesting and awaited expansions and improvements.
Part of the reason for this continual drive for enhancement is that the public cloud has turned into a bit of an arms race between Microsoft and Amazon. There are also many other companies hoping to grab some of this huge potential market, and there is strong evidence that Microsoft is following through with its promise to make Azure the foundation of the company.
Microsoft has always done better with a viable competitor breathing down its neck or, better yet, out ahead. One has only to look at the history of innovation with early versions of SQL Server or Internet Explorer to see that when its status as the market leader is threatened, Microsoft turns on the urgency, and the winners are usually consumers of the products regardless of which company ultimately wins said arms race.


text:
farming & rural life
conferences/calls for papers
fellowships/grants
choose another category
batik/dye
mixed media textiles/fiber
textiles-other
Information for artists interested in displaying their work
PortalWisconsin.org accepts submissions from Wisconsin artists who are interested in displaying their work in this juried, online gallery.
home >> online gallery >> textiles >> denise cawley
Denise Cawley
medium: textiles
Click on the image to see the full version.
Birds of Paradise Remembrance
Clover Joy
Complementary Color Explosion
Iris II -- Night Sky
Iris V
Lily Collage
date not given
Sunny Paradise
West Milwaukee, WI 53214
Email Address: dmcawley@earthlink.net
Web site: www.pizzazzstudios.com
While I have worked with fiber arts (papermaking, bookmaking, fabric dyeing, batik) for ten years, my interest in quilting didn't develop until 1997, when I worked with Nancy Crow's vibrant, contemporary quilts. My life changed. I learned to sew, integrating my love of color and layered fiber art into original quilt designs. My quilts use my hand-dyed fabrics, free-motion embroidery and appliqué techniques to create pieces are often referred to as three-dimensional quilted paintings.
Denise Cawley owns Pizzazz Studios. In Cawley's studio, she dyes one-of-a-kind fabrics for quilting and decorating and creates art quilts and fiber art pieces that hang in museums, galleries and private collections.
Cawley uses her long-arm quilt machine to complete quilt tops for people who want an artistic flair added to their pieces. She also lectures and gives workshops to guilds and teaches workshops throughout the U.S. Her own art uses hand-dyed fabrics and thread drawing to explore subjects in the natural environment. Cawley has been creating fiber art and dyeing fabric for more than a dozen years. She was trained at Parsons School of Design in New York City and completed her degree work at Alverno College in Milwaukee.
about portalwisconsin.org -- portalwisconsin.org is a nonprofit web site created by the partners of the Cultural Coalition of Wisconsin to support the state's culture, arts, humanities and history.
portalwisconsin.org partners
Wisconsin Academy of Sciences, Arts and Letters | Wisconsin Arts Board | Wisconsin Historical Society
Wisconsin Humanities Council | Wisconsin Library Association | Wisconsin Public Radio | PBS Wisconsin
University of Wisconsin-Extension--Continuing Education, Outreach & E-Learning
If you have comments or questions, please contact us at artsboard@wisconsin.gov or call us at 608-266-0190.
If you have trouble accessing this page, require this information in an alternate format or wish to request a reasonable accommodation because of a disability contact: artsboard@wisconsin.gov © 2014, all rights reserved


Find Gravel Crusher in Canada Visit Kijiji Classifieds to buy, sell, or trade almost anything! New and used items, cars, real estate, jobs, services, vacation rentals and more virtually anywhere in Saskatchewan. SMALL HAULS RD CR ROCK BASE GRAVEL SAND CRUSHER DUST.
2018 9 29 · Gravel / ˈ ɡ r æ v əl / is a loose aggregation of rock fragments. Gravel is classified by particle size range and includes size classes from granule to boulder sized fragments. In the Udden Wentworth scale gravel is categorized into granular gravel 2 to 4 mm or 0.079 to 0.157 in and pebble gravel 4 to 64 mm or 0.2 to 2.5 in.
The small, colorful rocks make for a colorful above ground layer of rock in landscaping that is not hard on feet. One use of pea gravel is to create a walkway. Easy to set up and cheaper than a concrete pathway, pea gravel can be laid down in any garden for a pleasing aesthetic feel.
We are a locally owned business long time residents of Bartow County. We specialize in small pickup delivery of our landscape products. Mulch, River Rock, Pea Gravel, Stone, Brick, Crushed Brick Mulch, Crisom Stone, Sand, Dirt, TopSoil, Gravel, 57 Stone, Crusher Run.
2018 5 5 · If your processing site is in narrow ground, the portable rock crusher or mobile rock crusher with features of light weight and small volume can be a best choice for you. 2. Since the portable rock crushing plant enjoys the feature of automatic movement, you can save the cost and time for carrying and fixing the machine.
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2017 11 8 · There are various kinds of rock crusher both at home and abroad, and they are different in sizes, specific functions and so forth. For example, there are large motor operated crushers and hand applications for smaller rocks. To make a rock crusher by yourself will be a better alternative.
Kijiji Alerts are an email notification service where Kijiji users can have the newest Ads sent to your email address. More Help Get an alert with the newest ads for rock crusher in Alberta .
2013 11 16 · Crusher small gravel making equipment gravel shaker mincing If you need more information about Crusher small gravel making equipment gravel shaker mincing machine, out of small from the shaker screen sand.
2010 8 27 · Small rock crusher ? Discussion in 'Heavy Equipment Pavement' started by tallrick, Apr 13, 2010. tallrick LawnSite Senior Member. from South Florida. My crusher is a 12 x 9. I used a small hydraulic rockbreaker to size the lumpy concrete which was leftover from a series of pours. Video shows another recent job.
small gas powered rock crusher Central Silent Hill Silent Hill Wiki FANDOM powered by Wikia Central Silent Hill is the main business district of the town of Silent Hill and is located just east of Old Silent Hill on the other side of the river that separates the two districts and north of the Resort Area.
small crusher for gravel available in philippines Gravel River Rock Classic Rock Stone Yard. Gravel River Rock. Putting gravels or river rock in an area where grass doesn't grow is an inexpensive way to make your muddy back yard look a little more stylish! Free Quote.
small crusher unit for making sand Coal mobile crusher machine,the mill for. small crusher unit for making sand in india. The highly efficient sand making equipment manufactured by Caiman also called small gravel crusher.
Our crusher can be divided into large, medium and small size according to the treatmen capacity. The feed openingposed of two jaw plates of moving jaw and jaw plate, which is a crushing chamber simulating the two jaw movement of the animalsplete the material broken.


What to do when you're not seeing results?
What is the answer, is there some special secret that I can give you? At some point you have to take charge of your mind and own it.
Fitness, health and having a great body all require the right elements. These elements aside from exercise, good food, water and rest are having patience, faith and perseverance. Muscles work best when they are challenged; that is when growth is stimulated.
Results come when there is an alignment of thought, word and action. The other day a friend of mine said, "talk is cheap." A lot of us say we're going to do something and don't do it. I believe that when things really come together it's because you believe in yourself and what you're doing. If you say you're going to do 5 days of training this week – do it! Keep that sense of integrity flowing in your life.
Results or what we define as success, is really a snowball effect of feel good emotions we have nurtured over time. Success is the joy we have felt along the way so to speak. You can get from here to there, but if it wasn't fun, enjoyable and empowering along the way, then our results will feel flat and unsatisfying.
The solution is to chip away at your goals on a daily basis. Make sure it feels like you are empowering yourself every step of the way. Sometimes you may feel lost (like on a car journey) and you don't know where you are going, but as long as you keep moving towards where you want to go, focusing on the end result – you will get there. Just don't hang around in the mood of, "I'm not there yet," or you will stay there forever. Results come from not getting caught up on where you are, but focusing on the end result or your destination.
Stress or a lack of sleep can get us disillusioned with our goals and may feel like you're not seeing results. When that happens take some time for yourself to recharge, rejuvenate and rest. Remember tomorrow is another day and don't try to be a hero and power through as that can lead to accidents and set backs. Nurturing yourself well in those times by eating well, taking more naps and drinking heaps more water will lead you back into that good place.
Remember patience, faith and perseverance will get you to your goals and will help build firm foundations of character as well body strength. Sometimes it may feel like an eternity, but keep at it, keep moving forward, keep believing, keep chipping away at your goals, don't be so hard on yourself up and you'll get there!


text:
17807 Ericpearce è un asteroide della fascia principale. Scoperto nel 1998, presenta un'orbita caratterizzata da un semiasse maggiore pari a 2,7242897 UA e da un'eccentricità di 0,1263718, inclinata di 18,41157° rispetto all'eclittica.

Collegamenti esterni

Corpi celesti scoperti nel 1998
Ericpearce

redpajama_set_name: RedPajamaWikipedia


text:
Biogen's Tecfidera holds its own in MS as competitive and generic threats loom
by Arlene Weintraub |
Biogen expects 2020 revenues of at least $14 billion, but SG&A could be 20% of sales, far outpacing the 17% analysts had been expecting. (Biogen)
Biogen's stock fell 14% over the last year as investors fretted over stagnating sales of its multiple sclerosis drugs, most notably its best-selling Tecfidera. But investors definitely perked up Thursday morning, when the company reported a better-than-expected performance from its MS franchise.
Amid competitive threats from several new MS drugs—and a patent dispute in which a key decision is expected next week—Biogen managed to grow sales of Tecfidera 5% during the fourth quarter to $1.2 billion. That helped drive the company's total MS revenues for all of 2019 up 2% to $9.2 billion.
Sales of Vumerity, the Tecfidera follow-up drug that Biogen launched late last year, came in at $5 million. During a conference call following the earnings release, Biogen CEO Michel Vounatsos told analysts he was optimistic about the newly launched product, largely because of the positive reception it has received from insurers.
"We are pleased with the access to date, which is superior to what we have seen from the competition a few months after launch," Vounatsos said.
RELATED: Biogen scores FDA nod for Tecfidera follow-up Vumerity as MS threats linger
Perhaps, but pressure from rivals shows no signs of letting up anytime soon. Recent MS launches include Novartis' Mayzent and Merck KGaA's Mavenclad. Then there's Novartis' cancer drug Arzerra (ofatumumab), which the company has been working to repurpose in MS. Results from clinical trials of the drug have been so impressive that a group of physicians polled by SVB Leerink late last year listed it as one of the most promising choices for treating MS, even though it has not yet been approved for that use.
As if branded competition isn't enough of a worry, Biogen is also facing the prospect that it could lose a key patent on Tecfidera. Mylan challenged the patent last year, and a decision from the Patent Trial and Appeals Board is expected in the first week of February.
Biogen is also facing competition in spinal muscular atrophy (SMA), though so far, it's holding its own there, as well. Novartis' gene therapy Zolgensma was expected to steal market share from Biogen's SMA drug Spinraza. But sales of Spinraza jumped 16% in the fourth quarter to $543 million and 22% for the full year to $2.1 billion.
"Zolgensma hasn't yet made too drastic of an impact," wrote Jefferies analyst Michael Yee in a note to investors. That said, Biogen could be facing another SMA rival later this year: Risdiplam, which Roche is developing with PTC Therapeutics. The two companies scored a priority review for the product late last year.
RELATED: JPM: Already prepping for Alzheimer's launch, Biogen scouts 'top talent' and talks pricing
Biogen told analysts to expect 2020 revenues to come in between $14 billion and $14.3 billion, with non-GAAP EPS of $31.50 to $33.50. That's about in line with expectations, though Biogen's expectation that its sales and administrative costs would be about 20% of total revenues was way above the consensus expectation of 17%.
Yee speculated in his note that the uptick in costs might be related to aducanumab, the Alzheimer's candidate that Biogen unexpectedly resurrected last year. Is the company attempting to "account for a potential aducanumab launch?" he asked in his note.
During the call, Vounatsos acknowledged that the executive team is so optimistic about Biogen's future in Alzheimer's that it's making concrete plans for aducanumab. "We are actively preparing for the potential launch of aducanumab, with an initial focus on the U.S.," he said. "This includes implementing the … go-to-market model, hiring the salesforce, building out our medical teams and preparing for market access."
Overall, Biogen reported total fourth-quarter sales of $3.7 billion, up 4% year-over-year, and total 2019 revenues that grew 7% to $14.4 billion. Non-GAAP earnings per share came in at $8.34 for the quarter and $33.57 for the full year, up 19% and 28% respectively, and beating the consensus estimates of $8.02 for the quarter and $33.20 for the year. Shares of Biogen rose more than 2% in premarket trading to $289.
multiple sclerosis Alzheimer's earnings spinal muscular atrophy Biogen Tecfidera Spinraza
Arlene Weintraub


text:
INTERCULTURAL LEADERSHIP INSTITUTE
The ILI Vision
ILI Year
ILI Zines
BRINGING THE BEST FORWARD
Mehanaokala Hind is the ILI Host Facilitator for Hawaiʻi, the location for the second of three place-based intensives for the ILI Fellows. She shared her thoughts about preparing to engage Fellows in Native Hawaiian experiences, encouraging their best, and facilitating healing cultural practices.
Photo: Melisa Cardona
Mehanaokala Hind is a Kumu Hula and cultural practitioner skilled in hula and oli. She descends from the hula lineage of Kumu Hula Leinaʻala Kalama Heine and earned the rank of Kumu Hula in 2009 when she completed the 'uniki rites set forth by her Kumu. She has been trained in mele oli from some of Hawaiʻiʻs master chanters. Mehana brings a breadth and depth of relationships with Native Hawaiian communities, leaders, schools and organizations that is hard to match. She has extensive experience in the University of Hawaiʻi and Community College systems, Charter Schools, Native Hawaiian non-profits, Immersion schools, and other Native Hawaiian-serving organizations and Trusts.
What is your role in this first ILI Intensive?
My role was as the site facilitator for Hawaiʻi. I partnered with the other two program facilitators.
How did you prepare for this week-long convening?
I knew that the Fellows group had a challenging ending in Lakota country and that we were going to have to work through that when the group came to Hawaiʻi. There was a lot of spiritual and emotional preparation I had to do. I chanted, I prayed, I went through the itinerary over and over so that I would know at any point that if I had to pivot in facilitating this group, I would be able to do that.
"Our mediation practice of Hoʻoponopono was the strongest cultural practice I had to bring forward."
What parts of your culture were important to bring to this experience?
Our practice of Hoʻoponopono was the strongest cultural practice I had to bring forward. Hoʻoponopono is our mediation process that involves addressing an issue head-on but using the facilitator as a haku, or a receiver of all the negative energy in the discussion of the issue. I also brought the core value of Aloha into the group and taught the group to chant it. Aloha is a very important word, value, and practice for our people and our relationship to land, water, ocean, gods, and each other.
How does the idea of "Interculturality" overlap with your work?
Interculturality overlaps in my work daily. I work for an agency whoʻs core responsibility is to care for, enhance, and perpetuate the well-being of the Native Hawaiian people, my people. I engage in work that, on behalf of our beneficiaries, we work alongside other cultures here in Hawaiʻi.
"At the onset of the intensive, I advised everyone that it was our goal, as Natives of this land, to have everyone leave Hawaiʻi better than they arrived."
What is the significance of having an ILI intensive here, in Hawaiʻi?
I believe that it was probably the most significant intensive because our homeland is a place that very few people get to experience. The fact that ILI brought everyone to Hawaiʻi is an incredible investment. At the onset of the intensive, I advised everyone that it was our goal, as Natives of this land, to have everyone leave Hawaiʻi better than they arrived.
Fellow Reflections
Fellows In The Field
ILI Alumni
ILI Hawaii
ILI Lakota
ILI San Antonio
Get the Qtrly E-Journal
Follow @weareili
A COLLABORATIVE PROGRAM
with Funding Support from:
Design & Editorial Content: Social Impact Studios / Art: Brice Media / Photos: Melisa Cardona, Carlton Turner, Luis M. Garza & Shannon Burnette


text:
Brooklyn Beckham and Nicola Peltz's wedding: 9 things you need to know
11/04/2022 11/04/2022 Melana 0 Comments Brooklyn Beckam
The bride wore Valentino and a couple of Spice Girls were amongst the guests!
By JESSICA SHERWOOD
Move over David and Victoria, the new Posh and Becks are here! Photographer turned chef Brooklyn Beckham and actress Nicola Peltz are offically newlyweds. The couple tied the knot yesterday at a star studded affair after almost three years of dating.
Here's everything you need to know about the wedding from the guests, to the venue and the most important info of all… the dress!
1. The pair were meant to be married in 2021 but postponed their wedding. After quaranting together for months in New York City, Brooklyn popped the question in June 2020, but couldn't wait to marry Nicola. Brooklyn told Hello! last year "If Covid wasn't a thing we'd have liked to have been married already," he also admitted the pair found planning a wedding during Covid "a bit difficult."
2. The bride wore custom Valentino. According to The Daily Mail, Nicola's gown was custom Valentino and the work of designer Pierpaoio Piccioi. Nicola flew to Rome twice to visit the studio to ensure her gown was perfect. The dress was an all-white long sleeved gown, with delicate lace detailing on the back in a keyhole style. Her veil also featured similar lace detail at the edges and was floor length, with a shorter piece in front of her face for Brooklyn to toss back and kiss his bride. We patiently await photos.
3. The ceremony was a Jewish one. Also per The Daily Mail, the couple wed under a flower-garlanded chuppah in a traditional Jewish ceremony in honour of Nicola's Jewish heritage. Brooklyn also smashed a glass wrapped in a napkin under his heel after they were married by the rabbi. Mazel tov!
4. They were married at Nicola's parents' ocean-view estate in Palm Beach, Florida. What could be more romantic than a beach wedding? According to the new Mr and Mrs Beckham, getting married on a $130 million family estate overlooking the sea instead. As per Sky News, the theme was white as the estate was decorated with white flowers and took place at 6pm in a giant tent on the oceanfront lawn.
5. Speaking of Nicola's parents, despite being a Beckham he had to sign a prenup. You might be the child of a Spice Girl/world famous fashion designer and a mega famous former footballer, but the Peltz family are kind of a big deal. According to The Daily Mail Nicola's father Nelson Peltz is said to be worth over $1.6 billion which is huge even compared to the Beckhams combined income of $494 million. Better to be safe than sorry I guess?
6. Harper Beckham was one of Nicola's bridesmaids! According to Heat, 10 year-old Harper was adorably all white in a puff sleeve dress and blue sash like Nicola's other bridesmaids.
7. There was basically a Spice Girls reunion. According to The Daily Mail 300 guests turned up to watch Nicola and Brooklyn tie the knot, but some guests are more important than others, namely ones of Spice Girl fame. Mel B and Mel C were in attendance alongside Victoria Beckham (ofc) making up three of the beloved five.
8. It was a very Instagramable and fashion forward affair. As well as the former Spice Girls, according to Sky News, Serena Williams, Eva Longoria, celebrity stylist Rachel Zoe and the Ramsay family all arrived to help celebrate the marriage.
9. Brooklyn Beckham might be taking Nicola's surname as a middle name. According to The Sun, Brooklyn plans on taking his wife's surname as a middle name. An insider told The Sun "Brooklyn is head over heels for Nicola – it's a huge sign of his commitment to her, and his love for her."
Harper Beckham looks so sweet in bridesmaid dress at Brooklyn and Nicola's wedding
Brooklyn Beckham shares first glimpse of wedding with 'beautiful bride' Nicola Peltz
← Brooklyn Beckham shares first glimpse of wedding with 'beautiful bride' Nicola Peltz
What does Brooklyn Beckham do for a living? Net worth, occupation and more explored as he marries Nicola Peltz →


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