The past few years have seen an explosion of heroin abuse and deaths from opiate overdose. But little is known about the molecular underpinnings of heroin addiction. A new study in Biological Psychiatry found that heroin use is associated with excessive histone acetylation, an epigenetic process that regulates gene expression. More years of drug use correlated with higher levels of hyperacetylation. The study, led by Dr. Yasmin Hurd of the Icahn School of Medicine at Mount Sinai, New York, provides the first direct evidence of opiate-related epigenetic alterations in the human brain.
To narrow in on these alterations, first author Dr. Gabor Egervari and colleagues studied postmortem human tissue — a challenging but critical endeavor for understanding the molecular organization of the human brain — from 48 heroin users and 37 controls. They focused on the striatum, a brain region implicated in drug addiction because of its central role in habit formation and goal-directed behavior.
The acetylation changes were observed at genes that mediate glutamatergic function, specifically the glutamate receptor gene GRIA1, which has previously been implicated in drug use. The epigenetic impairments reflect changes that increase accessibility of chromatin, a process that enhances gene transcription, suggesting the impairments play an important role in addiction behavior.
"At this time, when prescription opioid use and opioid overdoses are both major threats to our public health, it is important to identify new treatment targets, such as epigenetic processes, that help to change the way that we do business in treating opioid use disorders," said professor John Krystal, Editor of Biological Psychiatry.
"Epigenetic marks are physical alterations to the DNA that do not change the sequence of a gene, and thus have the potential to be reversed," said Hurd. So the researchers used a rat model of heroin addiction to test this idea. Importantly, rats allowed to self-administer heroin displayed the same hyperacetylation alterations that were found in the human brains.
Dr. Egervari and colleagues treated the rats with JQ1, a compound originally developed against cancer pathology, which inhibits acetylation. The drug reduced self-administered heroin taking in the rats. Importantly, JQ1 also reduced drug-seeking behavior after abstinence from heroin, suggesting it might be beneficial for long-term heroin users.
"Our findings suggest that JQ1 and similar compounds might be promising therapeutic tools for heroin use disorder," said Dr. Hurd.
The analogous epigenetic impairments found in the heroin-taking rats also indicate this animal model will be useful in further studies to identify addiction-related changes that translate to the human brain.
The article is "Striatal H3K27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target," by Gabor Egervari, Joseph Landry, James Callens, John F. Fullard, Panos Roussos, Eva Keller, and Yasmin L. Hurd (http://dx.doi.org/10.1016/j.biopsych.2016.09.015). It appears in Biological Psychiatry, volume 81, issue 7 (2017), published by Elsevier.
Copies of this paper are available to credentialed journalists upon request; please contact Rhiannon Bugno at +1 214 648 0880 or biol.psych@utsouthwestern.edu. Journalists wishing to interview the authors may contact Yasmin Hurd, Ph.D., at Yasmin.Hurd@mssm.edu.


Woods and Pears – The iconic Woods design has borne fruit; a new range of colourways featuring metallics to glimmer and catch the light as you move through the room makes a beautiful fairytale design.
The wallpaper calculator works out the precise quantity of Woods and Pears for your dimensions taking into account the pattern repeat of 70 cm. Please note we allow 10% waste in case of any problems while hanging. In a small number of circumstances 10% can mean you may get an extra drop out of a roll.


text:
Hajizadeh says air defense system mistook plane for a cruise missile
'I wished death' after realizing Ukrainian passenger plane had been mistakenly shot down: IRGC Aerospace Force chief
January 11, 2020 - 13:53
TEHRAN — Amir Ali Hajizadeh, commander of the Aerospace Force of the Islamic Revolution Guards Corps (IRGC), said on Saturday that he wished he was dead when he heard that his forces have downed a Ukrainian aircraft which crashed near the capital Tehran on Wednesday morning.
"After hearing the news in the country's west after implementing the military operation against American bases and when I made sure that this incident has happened, I wished I was dead," said Hajizadeh said a press conference on the Ukrainian plane crash.
"For a lifetime, we put our life on the line for the people, and today we put our honor on the line for God and face the cameras in such difficult circumstances," he said.
Hajizadeh accepted full responsibility for the incident, saying he had notified related authorities immediately but the public announcement of the matter was pending an investigation by the Armed Forces General Staff as required by existing procedures.
Hajizadeh said Iran's air defense systems had been put on the "highest level of readiness" and alerted to a possible cruise missile attack prior to the plane crash incident.
"Neither the Guards nor the armed forces never intended to cover up, but this was a process that had to be perused," he said, according to Press TV.
He added that further judgment on the matter was the responsibility of the higher authorities and the Judiciary and that "we will comply with any decision taken by them".
All 176 crew members and passengers, 147 of whom were Iranians, died in the Ukraine International Airlines (UIA) crash which came a few minutes after take-off from Tehran to Kiev on Wednesday.
The IRGC aerospace chief added that the operator manning the system had repeatedly called for a halt in flights in the region during the night.
He added that the operator then identified what his air defense system had detected as an incoming cruise missile 19 kilometers away.
The operator, as required by military guidelines then proceeded to call for orders to deal with the perceived threat, but wasn't able to do so as his communication network failed to work.
Hajizadeh added that the operator then "took the wrong decision" of firing on the perceived threat in a "ten-second" time span to shoot or ignore the flying object.
The general added that Iran's aviation authorities had no information regarding the matter and that they, along with the plane's crew, had conducted no wrongdoing in the incident.
The General Staff of the Armed Forces also issued a statement on Saturday saying that the Ukrainian plane crash was caused by a "human error".
"The Ukrainian passenger plane was hit unintentionally and due to human error, which unfortunately led to the martyrdom of a number of our people and also a number of foreign nationals," the statement read.
"Following threats made by the U.S. President [Donald Trump] and military commanders of attacking targets on the soil of the Islamic Republic of Iran in case of Iran's retaliatory operation, and due to unprecedented increase in movements in the region's airspace, Iranian armed forces were at the utmost level of readiness and alert," it added.
It came in the aftermath of a Trump-ordered U.S. attack at Baghdad's airport on January 3 that killed top Iranian general Qassem Soleimani.
Last Saturday, Trump tweeted that if Iran attacks any American assets to avenge the killing of Qassem Soleimani, the U.S. has 52 targets across the Islamic Republic that "WILL BE HIT VERY FAST AND VERY HARD."
"Let this serve as a WARNING that if Iran strikes any Americans, or American assets, we have.........targeted 52 Iranian sites (representing the 52 American hostages taken by Iran many years ago), some at a very high level & important to Iran & the Iranian culture, and those targets, and Iran itself, WILL BE HIT VERY FAST AND VERY HARD," Trump said. "The USA wants no more threats!"
Nevertheless, Iran took revenge for the assassination in the early hours of Wednesday.
The IRGC pointed to the successful Shahid (Martyr) Soleimani Operation against the Ain al-Assad base with tens of surface-to-surface missiles and warned the United States that any more aggression will receive more "painful and crushing" response.
MH/PA
Ukrainian civil airliner downed due to human error: Armed Forces statement
Lawmakers condole families of plane crash victims
147 Iranians, 32 foreigners killed as Ukrainian plane crashes near Tehran
Judiciary chief vows justice on downed plane case
General Amir Ali Hajizadeh
By triggering dispute mechanism, Europe proves its incapability: Salehi
Iran's UN envoy says Gen. Soleimani's assassination is a hard blow to peace
TEDPIX, IFX climb on Wednesday
Iranian banks pay over $149b loans since mid-March 2019
Nearly 4,300 electricity projects inaugurated across Iran in a week
Iran's 9-month hydropower output up over 200%
Europe's policies only whet Trump's appetite, Zarif says
Girl students to write heartfelt letters to vice president
Trump acts like a criminal who pretends innocence
Medical tourist arrivals in Iran doubles in spring
Cooperative company for women vendors to be formed
Behdad Salimi wins Iran's 16th gold medal at Asiad
Developed by: Nastooh Designed by: Pixel Studio

redpajama_set_name: RedPajamaCommonCrawl


Fantastic way of helping unleashing creativity.
Everyone is capable of creativity - not just the chosen few. In this inspiring audio Julia Cameron offers new insights about her landmark best seller, The Artist's Way, which taught thousands of people to unlock their creative potential. Cameron presents a series of simple exercises that will instill the creativity "habit" and dispel the "anti-art" conditioning that prevents so many of us from achieving our deepest ambitions. She shows us how to explore the divine gift of our own creativity, use our imagination's unlimited capacity for transformation, and reap the benefits of creativity's life-changing power. This practical, inspirational guide from an award-winning author also includes an informative live lecture and a studio question-and-answer session.
The sound quality isn't as bad as "Vein of Gold", but you do have to listen past it. Nevertheless, it's worth listening to if you have the least interest in your creative side. You don't have to quit your job and paint or anything; you can be creative in any way, at anything. This can help you use more of your skills and talents with less angst.
i think julia cameron is great, I love her philosophy and faith.
Unfortunately this recording sounds like it was made with a microphone covered in a sock. why would that be? Better sound quality and I would give this a 4 star review!
Uniquely helpful. I enjoyed every minute of it.
Easy and fun information. Serious info, but presented in a way you can absorb. Funny and witty.
I absolutely love this book and Julia Cameron's voice. It will be a long time favorite!
The Artist's Way - Jumpstart your creativity!
I am pleased to say that this audio book is a worthy addition to my library. It dovetails seamlessly with Julia Cameron's flagship book 'The Artist's Way' giving valuable context as well as highlighting the key lessons in the 12 week course. The audio book is divided into three sessions: Parts 1 and 2 are from a lively seminar, whilst the final session is interview style. Julia Cameron draws upon a lifetime's work and experience (and tried and tested tools e.g. Morning Pages) and therein lies the beauty and value of this recording. Furthermore I have no doubt many listeners and reflective practitioners will enjoy and reap the rewards from the advice and creative insights discussed. To get the most out of this recording I highly recommend reading the book 'The Artists Way' to which this recording refers; or equally stimulating 'The Right to Write'.
A great book especially if you are ready to be challenged. It enables you dig deeper into self, confront excuses, providing tools to create your own change. An opportunity to embrace, discover and enjoy the real you inspired through creativity.
please please listen to it if you like (I adore!) artist way!.. julia is amazing... I have always felt this is a channelled book!
A wonderful insight into the power behind the Artists way and Julia Cameron's fantastic creativity. The listener learns a little of how Julia thinks but also her compassion for fledgling artists and the experienced. An enjoyable but also educational book.
Yes, you feel as if you are part of the audience listening to some very sage advice delivered with great humour - I could have listened for hours.
Have you listened to any of Julia Cameron's other performances? How does this one compare?
No, this is the first of her books I have listened to and am currently searching for another.
Not that I recall - I just felt really engaged in the delivery and my only disappointment was when it finished - could have done with a couple more hours.
One of the best audio books I have listened to and so motivating for anyone wanting to get out of the starting blocks.


text:
<?php
declare(strict_types = 1);

namespace Tests\Innmind\TimeContinuum\Earth\Timezone\Atlantic;

use Innmind\TimeContinuum\{
    Earth\Timezone\Atlantic\SouthGeorgia,
    Timezone,
};
use PHPUnit\Framework\TestCase;

class SouthGeorgiaTest extends TestCase
{
    public function testInterface()
    {
        $zone = new SouthGeorgia;

        $this->assertInstanceOf(Timezone::class, $zone);
    }
}

redpajama_set_name: RedPajamaGithub


text:
Capriati's first day at No. 1 ends with doubles loss
Team WTAworld, Administrator, aka Nibbler
ZURICH, Switzerland (AP) -- Jennifer Capriati began her reign as the world's No. 1 player Monday with a straight-sets loss in doubles at the $1.2 million Swisscom Challenge.
``The doubles don't count. I've lost many doubles matches,'' Capriati said laughing after she and Megan Shaughnessy fell 7-5, 7-6 (4) to Lindsay Davenport and Lisa Raymond in the opening round.
``But I can still finally breath a sigh of relief,'' she added. ``It's official today. I can't describe the happiness and satisfaction I feel. It's something now no one can take away.''
In singles, Chanda Rubin defeated Spain's Angeles Montolio 6-1, 6-3, and Austria's Barbara Schett downed Spain's Magui Serna 6-1, 6-2. Russia's Nadia Petrova routed Swiss favorite Patty Schnyder 6-2, 6-0.
Capriati supplanted Martina Hingis as the world's top-ranked player earlier in the day. Hingis lost her 73-week hold on the top spot after tearing ligaments in her right ankle Saturday in a semifinal against Davenport at the Porsche Grand Prix.
Capriati's ascent completed a long comeback from personal and legal problems.
``It's been a long road,'' she said. ``It's something a lot of people thought I could never do. Something I wasn't sure of myself.''
The youngest Grand Slam semifinalist ever at the 1990 French Open at 14, the youngest player to win a match at Wimbledon, and the youngest player to crack the Top 10, Capriati's promise soon soured.
Burnt out and struggling to cope with the pressures of success, Capriati dropped out of the tour in 1993. She fell out of the rankings in 1994.
After two years, Capriati clawed her way back into the rankings in 1996, finishing the year at No. 24. However, she dropped to 267 in 1998.
But she persisted and won her first tournament in six years in Strasbourg, France, in May 1999.
At the 2000 Australian Open, she reached her first Grand Slam final in nine years and moved back into the Top 20.
At the Australia Open this year, Capriati became the lowest-seeded woman to win a Grand Slam and she returned to the Top 10 for the first time in seven years. She went on to win the French Open and reached the semifinals at Wimbledon and the U.S. Open.
``This has definitely been unique for me,'' she said. ``It's been a unique story for everyone. It hasn't turned out as expected.
``I wouldn't go back and change anything. Who knows if I would have gotten here if everything had gone the way it was supposed to? I'm happy where I'm at now. I wouldn't want to change anything at this point.''
Milow : http://www.youtube.com/watch?v=o32x-kHGaTo
Josh Oct 15, 2001


text:
GreekReporter.comGreek NewsCultureAriana Rockefeller Vows to Continue Family Interest in Greek Issues
Ariana Rockefeller Vows to Continue Family Interest in Greek Issues
Ariana Rockefeller (L) with Lina Mendoni, Greece's Minister of Culture and Sports
Ariana Rockefeller, the granddaughter of philanthropist David Rockefeller Sr., said on Wednesday that she will continue to be involved in Greek issues during her meeting in Athens with Lina Mendoni, Greece's Minister of Culture.
The Rockefeller heir also related that her family's relationship with Greece goes back decades. Her grandfather, John D. Rockefeller Jr., appreciated and adored all things ancient, especially the history of ancient Athens, Pericles and the creation of the Acropolis.
David Rockefeller maintained his family's love for Greece and ancient Greek culture by visiting Mount Athos as well.
In 1929, the Rockefeller Foundation provided the capital to complete the construction of the Museum of Ancient Agora along with scholarships to train archaeologists. In addition, it funded continuing excavations in the Agora throughout the 1930s.
During their meeting, Rockefeller gifted the Minister of Culture and Sports with a volume of her grandfather's memoirs along with a copy of the record of a donation from the Rockefeller Foundation in 1949.
This bequest gave $150,000 to the American School of Classical Studies to continue their work excavating the ancient Agora. The original document is found in the archives of the Rockefeller Foundation in New York.
Ariana Rockefeller is frequently seen supporting major New York arts and culture organizations. She is a Junior Associate at the New York Museum of Modern Art and supports the Costume Institute at the Metropolitan Museum of Art as well as the New York Botanical Garden and the Lincoln Center for the Performing Arts.
Ariana Rockefeller
Turkey, Armenia Hold Rare Talks to Normalize Relations
Olive Oil May Help You Live Longer, Lower Risks from Alzheimer's Disease
Greek Photographer Wins Award with Stunning Images of New York's Street Life
Turkey No More: Erdogan Changes Country's Name to "Turkiye"


text:
Sunday Reflections: Big Z, Little Glass Gallery & A. Rob
Bat Country Studios is the busiest it's ever been. Jon Weiss has been working on his mandala series like a maniac this summer and finally debuted them at Piece Gallery in the Vail Village. We are all thankful to Eva for her continued support of the studio, as she is the only art gallery in Vail specializing in glass. It's amazing to have support from our local community.
Community has been a focus for us since the beginning, and now more than ever. I recently read a book called "This is not a T-shirt" by Bobby Kim of The Hundreds, one of my favorite streetwear brands. Among so many other insights, Bobby stressed the importance of community in building a brand. I reached out to Bobby, who somehow found the time to respond to my DM in his sea of messages from other entrepreneurs and fans. While he didn't agree (yet) to a collaboration between our brands, he did agree to a trade that I'll tell you more about next week. He confirmed receiving the cup I made him, now I'm just waiting on my package!
Don't be afraid to go for it. Cast a wide net. With quantity comes quality. Don't be afraid to hear the word "no." Rejection is ok.
So we started a weekly open house at the studio, which anyone can attend. Taco Tuesdays at Bat Country is a thing, and we have to thank our butcher Colorado Meat Company for sponsoring with ground beef and organic produce week after week. This is community.
We're getting close to establishing a Minturn Creative Arts District after months of meetings and work. Our working group is close to securing funding to connect the working artists and creatives in our town and provide more resources to each other. The Vail Art Guild hosts a monthly First Friday gallery show in Minturn, and some of the artists I've met in Minturn didn't even know about it. We're trying to connect the dots for this and so much more. Minturn is a special and quirky town, and we want to keep it that way.
We made time to visit another local artist, Armando studio in Vail. Armando has been involved in our art swap at the studio and is a regular at Taco Tuesday. He has a few laser engraving machines and we're working on some collaborations that should be available on the website soon. I love visiting friends' studios and work spaces as a way to get to know a person. There is a feeling that is very important beyond words about the space where a creator creates. It's the tools they use, the things that inspire them on a daily basis. It's a feeling unique to each and everyone's personal experience. Just over two years into my first personal studio I'm starting to understand just how important that space is.
Yesterday was a very special day I had been long awaiting as well. Big Z threw his annual house party in Denver. Before I talk about that, I want to share a little bit of my history with Zach.
We met in Madison, Wisconsin in a stairwell at a Glassroots trade show in the Monona Terrace. It was over five years ago but I can't say when for sure. Definitely before I moved to Colorado, and probably when I was still working for my teacher Huffy. So Z and I talked for ten minutes during our walk from the parking to the convention hall, and I let him know how much I looked up to him and appreciated his work.
Fast forward to 2015 when I moved into Joel Halen's studio in Fort Collins, next door to Big Z's shop. I had no confidence when I started over there. I was hardly a glass blower, but I was trying my hardest. One day I popped over to Zach's shop in the morning to say hey before Joel got to his to let me in. I couldn't believe Z remembered me from that conversation years before, but he did.
My year in Fort Collins was tough. I didn't have friends up there, and Drinking Vessels was in its infancy. I was coming off the most challenging year of my life, trying to make it in NYC where I commuted five hours a day to get to the glass studio in Long Island, band rehearsal in Brooklyn, and whatever couch was available to me in Manhattan to catch some sleep and maybe shower.
Zach was always tough on me, or maybe just straight to the point. He criticized my work in a way that pushed me to do better. He's that big brother who gives you shit, but it's all love. I'm a better person for knowing Zach, and I'm grateful for the friendship we've developed over the years.
One time he gave me some space prep for a collab, and I carried it around the country for at least six months before I had the confidence to make it into a cup. I'll never forget warming up that two inch ball in the kiln and making our first collab in Austin, TX. I still have the cup on my shelf, and it's one of my most cherished. I even signed it twice (by mistake).
Our second collab was a stemmed goblet that sold in an auction. We had a fun afternoon, and Zach helped me out with some tips on coil potting color, a fundamental skill I was learning over five years into my glass career. I remember a feeling back then, being so afraid to fail that I let fear paralyze me and kept me from trying many things. Zach saw this and pushed me along with many others to get where I am now.
In 2017 I bought a pair of cups from Zach. One sold and the other is my personal (lemon drop and space tech) and sits next to our first collab on my shelf. I break it out on special occasions, like yesterday's party.
So Rob, J. Cost and I drove to Denver early yesterday morning to meet up with a few collectors who came in for Zach's Show. What I mean by a few collectors, is that two of the people who are responsible for Drinking Vessels making it to this day are also two of the biggest Z collectors and I've noticed that Z collectors are unique in a lot of ways from the rest of the glass community. I can't put it into words, but this is a very special group of people.
The Little Glass Gallery is my closest contemporary in cup collecting, and in many ways we've been collecting together over the last few years. I recently got to visit his personal collection in California, and I've never seen anything comparable. His personal collection rivals the collection of Drinking Vessels entire selection of available work in stock. He was the first guest to pull up to Denver Biscuit Company yesterday morning, straight from the airport. He's probably my favorite person to talk cups with, no offense to everyone else (sorry!)
Shortly after that our dear friend Alex (A. Rob) pulled up (in a Tesla of course) and for the first time these two legends got to meet face to face. We took a table on the patio, but not before I grabbed cups and mugs from the car to dine with. A. Rob is currently on his way up to Vail to spend the day with us before continuing on his travels. He's currently living in Mexico, but the Vail Cup Collectors Club, the Big Z show and a few other events bring him back to the states every few months. Years ago Alex booked my flights and accommodations for the Michigan Glass Project in exchange for a Kevin Howell's Heady Hydrator so that I could attend the event, volunteer, and contribute. We've maintained a friendship since meeting in Manhattan before that, and he's one of the people I speak with weekly as a friend and for business advice with DV.
These two guys have kept Drinking Vessels going with their support over the years in times when it felt like I could go weeks without selling cups. These guys have helped to bring some of the biggest drops to this website, by committing to purchase work before it got released so that I knew I could afford to pick up a bigger variety from artists I wanted to share with all of you. These guys have flown me around the country for events and glass deliveries when I could hardly afford ramen noodles. The Little Glass Gallery rented me a Porsche in LA when I delivered his cups, at a time when I couldn't even afford the cheapest economy car on the lot. I'm eternally grateful to these two collectors, who have both become very dear friends of mine. It was such a joy for me to spend brunch with them, as well as J. Cost and Rob from the shop.
Lastly, but definitely not least, we went over to the Big Z house party for the afternoon. Some of you know how infrequently I dab, but yesterday was a day to indulge. Shoutout to Regal Rosin for sponsoring, and supplying us with killer flavors all afternoon. What a collection of such an incredible body of work. There were tables full of Z solo and collaborative work that everyone brought out, and the new releases were certainly some of his most impressive work. Among everything, my favorite piece was a dry sherlock for flower that Zach and Voorhees made; space tech between Lotus White, with a Voorhees face for the can. This was a beautiful specimen, though I'm not currently shopping for my personal collection so I couldn't scoop it. We had a great time getting to know everyone, and spending time with close friends. My old boss Joel Halen even showed up and I joked with him about how I was his favorite employee!
P.S. I'm a terrible employee.
So now it's time to go meet A. Rob at the studio so we can have one last adventure before he leaves town. I'm thinking off-roading Shrine Pass, so tune into the Instagram story!


Thank you for trusting BYOB for your Hot Sauce needs! Our team is dedicated to making sure you are happy with your products.
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We welcome you to Portsmouth's website. This website seeks to inform its citizens and others about ongoing projects and events in Portsmouth and also serves as a database and reference resource for information about our town.
Portsmouth is a small town in the heart of America. We have an volunteer fire department and county sheriff. We provide and invoice monthly for the following services: water, sewer and solid waste.


text:
Röda havets delning (hebreiska: קריעת ים סוף Kriat Yam Suph - Korsandet av Röda havet) är en berättelse ur Andra Moseboken (13:17-14:29) i Gamla testamentet. Det förekommer också i Koranen i Surah 26: Al-Shu'ara' (Poeterna) i verseerna 60-67.

Enligt Andra Moseboken höll Mose upp sin stav, och Gud delade sedan upp havet. Mose och övriga israeliter skall sedan ha kunnat gå på havsbotten, fri från vatten, ut ur Egypten. När Egyptens armé följde efter dem reste Mose åter sin stav, och vattnet kom tillbaka och de egyptiska soldaterna drunknade.

En naturvetenskaplig förklaring till händelsen presenterades 2010 av forskare från USA, som hävdade att fenomenet kan ha orsakats av stormvindar. Andra naturvetenskapliga förklaringar har varit tidvatten.

Källor

Fotnoter

Gamla testamentet
Delning
Mose

redpajama_set_name: RedPajamaWikipedia


text:
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Puritanism arose in 16th and 17th century England as a continuation of the Protestant Reformation. Adherents believed that the English Reformation had not gone far enough, that many aspects of the Church of England needed further reform, even "purifying". The Puritans were influential in the early English settlement of America and in the civil war and revolution of the 17th century.


text:
Q: Как в WebView загрузить картинку из памяти? Создаю картинку вот так:
img1 = Bitmap.createBitmap(300, 300, Bitmap.Config.ARGB_8888);
        canvasImg1 = new Canvas(img1);

Как указать при формировании HTML разметки, что картинку вывести не из Assets, а взять img1 (созданную программно) для использования?
Разметка HTML:
String txtHTML = "" +
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        "
Page HTML
"+
        "";

A: Попробуйте вот так преобразовать картинку в строку и подставить её в src атрибут в html:
// Desired Bitmap and the html code, where you want to place it
Bitmap bitmap = YOUR_BITMAP;
String html="";

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redpajama_set_name: RedPajamaStackExchange


The current pushed against him, the water high and rushing; his feet slipped on the slimy green rocks. What felt good at first had become dangerous. One blunder and he'd slip under. Kent had never been a strong swimmer. How cold would it be under there, legs and arms stretched out like a big X, face up in the water, floating on to Tokyo and into the Pacific right on out of this island country? He looked to the other side, its steep bank nearly thirty meters away and covered in green grass, bobbing nests of dense green vine, and trees that leaned into the river, their branches and leaves pulled by the high water. He had to get out before something stupid happened. He stepped backward, stumbling and sliding. The water grew deeper and closed around his balls in an icy grip. He stood with his arms up and out at his sides, a ridiculous figure once again. He could no longer tolerate the life he lived, something had to change. Midori was right: Have you seen yourself, Kent? As he turned in the rushing water toward the bank, which seemed to stretch farther and farther away, Kent put his foot down in an overconfident search for a rock and found a hole instead. He went under, flapping his arms above his head in an attempt to stay upright, swallowing a gulp of river water.
As he surfaced, water rushed in his ears and he took in another mouthful. He coughed till his chest burned—as if matches were lit in his lungs—but he couldn't stop coughing. I'm drowning, he thought, in four feet of water. How stupid. A final stupid act to close a stupid life. Kent drummed his feet over rocks but couldn't steady himself as the river caught him in its current and pushed him downstream with the sand and the deadwood. Panic took hold, his stomach and chest tight, still on fire, his throat achy and the water sour and cold in his mouth like a bitter tea. His foot caught between a rock—a foothold—but his ankle twisted painfully. Kent bit hard into his tongue as his knee slammed up into his chin and he tasted blood. He tried to spin his body, again flapping his arms in the air and water, but the current pushed him forward, twisting his torso upriver and his legs towards Tokyo.
High up on the riverbank, Kent caught sight of a blurry figure in yellow. Would Ozman watch him drown, the river doing his dirty work for him? A wave of water washed over his head. When he looked up to the riverbank again, the yellow figure was gone. He wanted to reach up and pull Ozman, if it was him, into the cold water with him—just the two us now, friend, but he ran his knee into a large shallow boulder. As he reached his arms around the big gray rock, someone called his name. He could turn, he knew, and see his nemesis—how odd to have a nemesis—grabbing his crotch and laughing at Kent drowning before him in the river. He pressed his cheek to the cold rock and hung on, afraid to turn his head and look. With his name on the air, pulsating pain around his ankle and knee, the water rolled over him and all he could think about was the hockey bag that held his life's belongings, Allan's urn. How pathetic he would look to embassy officials when they gathered his body and his few possessions to ship home and discovered that he had no home, no place at all.


text:
Categories News, Videos
Video: Hillary Clinton's Keynote Address at DNC in Denver
iHipHop Admin
Mrs Clinton, who was given a standing ovation as she took the stage, thanked those who supported her through her primary campaign but said Mr Obama was now "my candidate".
"Whether you voted for me or voted for Barack, the time is now to unite as a single party with a single purpose."
President Obama: Kendrick Lamar's "How Much a Dollar Cost" Is My Favorite Song of 2015
In a recent interview with People magazine, President Obama said Kendrick Lamar's "How Much a Dollar Cost"—from this year's awesome To Pimp a Butterfly album—was his favorite song of 2015. Conversely, First Lady Michelle Obama's favorite song was Mark Ronson and Bruno Mars' "Uptown Funk". In case you ever doubted Obama's cool, et it be immediately dispelled with this news. Read the rest of the interview after the jump, via People.
Video: Watch Waka Flocka Discuss Hillary Clinton, Kendrick Lamar, Emojis & More
Waka Flocka Flame is the latest artist to join Pitchfork's "Over/Under" series, in which a litany of random topics are evaluated and declared if they're overrated or underrated. In this latest episode, Waka Flocka Flame discusses how he feels about Kendrick Lamar, whether or not he likes emojis, Hillary Clinton and the presidential race, and much more. Check it out after the jump.
7 Best Husbands For Beyoncé After Dumping Jay Z
To the left, to the left. Sending off Hov in a yacht to the left. According to TMZ and HuffPost and about 10,000 sweaty fans, Beyoncé modified the lyrics to her song "Resentment" to call out Jay Z for cheating. This is the moment thirst vacuums and Hov haters have been waiting for: the divorce that makes Beyoncé single again. But all you 9-to-5ers and basic hood vendors can say goodbye to the dream that never was. Bey ain't marrying you. We came up with a list of chaps she might give a second glance once Team Yonce and handlers review. Hit the jump and click through.
Pages: 1 2 3 4 5 6 7 8 9
Updated: ScHoolboy Q Detained After Shooting At Concert In Colorado
Shots were fired outside a Nas, ScHoolboy Q, and Flying Lotus concert at Colorado's famed Red Rocks Amphitheater last night. The shooting, which injured three people, forced the venue to be shut down as law enforcement searched for a black male with a rifle. No arrests have been made, although ScHoolboy was detained by Jefferson County Police.
Snoop Dogg On Why He's Not Voting For Romney & Voting For Obama
Valid points...hit the jump for a closer look.
Staff Picks Week Of 9/10/12
Obama's Kick Game Proper
Dude Arrested For Shooting At The White House


Jonathan has extensive experience in communications and journalism. After five years as a reporter, commentator and features editor for The Municipal Journal, in 2015 he became the first strategic communications officer for the District Councils' Network.
Prior to The MJ, he edited an online government property and public estate magazine and helped run communications and marketing for anti-poverty charity Elizabeth Finn Care.
Bethanie joined the Localis team in September 2018 as a Senior Researcher. She graduated with a masters in Public Policy from the University of Manchester where she wrote a report for Stockport Council about the role of place based integration in delivering Greater Manchester's wider public service reform.
Prior to joining Localis, Bethanie worked for a public policy events company where she produced events on topics including: council income generation, devolution, housing and the private rented sector. Bethanie is passionate about feminism, the environment and local government issues.
Zayn joined the Localis team in August 2018 after spending time in Brussels and Paris working at different human rights NGO's. He graduated with a Masters in Conflict Studies and Human Rights from Utrecht University in 2016. His previous research experience is in minority and human rights, having written a report on the human rights implications of the China Pakistan Economic Corridor.
David's interests lie in local growth, local communities and local leadership. He has worked with some of the most influential voices in the devolution debate and believes there's little that can't be improved by greater local decision-making and empowered local leaders.
David has been adviser to two Secretaries of State and prominent council leaders. He has directed a LEP and has (well over) a decade's experience in senior positions in local government. Prior to this, David worked in both private and voluntary sectors.
James' background lies in operational management and improvement in the NHS. He has managed a number acute hospital services, including; accident and emergency, acute medicine, cardiology and gastroenterology. More recently, James has worked in consultative improvement roles across a broad range of public sector services, including; local government, adults and children's services, clinical commissioning groups, broader health services and the voluntary sector.
Neva has been working with local and regional governments and devolved administrations across Europe, helping them define and achieve policy goals. She is the Secretary General of the European Conservatives and Reformists Group in the European Committee of the Regions, the EU's political assembly of local and regional representatives. She helped form the Group in 2013 and has been the Secretary-General since. She has been at the center of the formulation and rolling-out the Group's European localism agenda. Previously, she worked as a policy advisor in the European Parliament. Her EU career began in the Enlargement Strategy Unit in the European Commission.
Neva's professional experiences have included working at the United Nations Development Programme and the Washington DC based Center for Strategic and International Studies (CSIS) Think-Tank. She was previously a visiting scholar at the Think-Tank Economic Policy Research Foundation of Turkey and an International AILA Fellow at the CSIS.


Sometimes, I do really daft stuff. This is one of those times. A few years back I threw together a few eggs, and made an omelette of a video of ineggscrable puns, all to the tune of Irving Berlin's 'Easter parade' on Electric guitar. Seemed like a good idea at the time! So, here it is again!
Several years ago, Miki and I were travelling through South-West Spain in our Motorhome, heading for Portugal. We chanced upon a little artisans market in a small Spanish village. I can tell you exactly when it was – June 25th, 2009. It was the day Michael Jackson died. We got the news as we browsed some art and got chatting with an amiable American at one of the stalls. He was there selling his artwork, and that of his girlfriend, a Polish stained glass artist called Justyna. We took to Ted straight away, he was a larger than life character. We exchanged contact details and promised to stay in touch.
We discovered he was from New Orleans, and the following year, we travelled to the American South on a road trip that inspired my Blue Odyssey album, and met up with Ted again, this time in his hometown. It was great to see him again, and he showed us around, took us for a Po' Boy sandwich, and introduced us to his friends at the Apple Barrel in Frenchman Street.
Today, as we holiday in Lanzarote, we discovered via the Fine Art America website that Ted had passed away. After spending some months in Mexico, he'd returned to N'awlins, and there he died.
Here's to you Ted, one of those characters that so enrich your life as you travel around the world. You were a good man, and you'll be remembered my friend.
Here's the third in my Metalhedz series of artworks. This guy's known as 'Spex'. He doesn't really need Spex, but he thought they'd look cool. Unfortunately, an unscrupulous opthamologist sold him a pair fashioned out of some second-hand frosted bathroom glass, so he can't see a thing with them, but he'll never take them off. Spex is often found hanging around stage doors waiting for metal stars, who've actually already left – he just didn't notice them…..
If you want to buy any professional, high quality prints of my artworks, you can find them at both Fine Art America anRed Bubble. Just click on the widgets below.


i upgraded (?) this nifty little menu bar weather app a few minutes ago and the upgrade (?) changes the look of the app entirely and i can't figure out how to get weather on other cities i check.
here's a screenshot of what it looks like now: current weather.
i used to get a box showing current local weather and, below that, access to weather in other locales.
i don't see anything that helps in the preferences.
does anyone else have experience with this? any idea how to access the other locales in the current iteration? should Meteorologist-3.1.4.dmg get me back to the next most recent update?
I don't know what you're running, but 3.1.6 is the latest version of the app and it looks nothing like that.
When updating from 3.1.4, I had to re-select "Dark Sky" as the source in the pref's. (The read-me says that you'll have to do that.) That was the only thing that was extraordinary about the update.
Did you download it from SourceForge? 'Cause getting it from anywhere else you probably installed something else entirely and it probably came bundled with (or is) malware.
Time to run a MalwareBytes scan?
Edited 1 time(s). Last edit at 02/10/2019 04:32PM by Sarcany.
I updated to 3.1.6 on one machine and it was just like Sarcany said - I had to switch back to Dark Sky, but otherwise, it 'looks the same.
i somehow had forecast bar 5.0.2 installed and not meteorologist. sheesh--sometimes i amaze myself.
thanx, y'all! sorry to trouble.


text:
Inoviem Scientific offers a range of services tailored to the needs of drug discovery, preclinical and clinical development.
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Compound pharmacology is always shown in a relevant model, whether cellular or animal. It is important to identify and validate the primary target in the very same model.
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With greater emphasis on translational pharmacology, any number of compounds can be profiled, and we can identify within four weeks of study which one of these offers the best 'druggability' to move forward into development.
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Our approach is based on the simple idea that current technologies fail to take into account the natural environment in which a drug will have its beneficial effect…
Inoviem Scientific's core values are deeply ingrained in our past, present and future; they guide us in our daily work…
At Inoviem, we are committed to contributing work that upholds the quality of life and well-being of individuals…
Supervisory board & investors
Dr. Pierre Eftekhari
President & Chief Scientific Officer (CSO)
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Dr Eftekhari is a life sciences entrepreneur with extensive world-class knowledge in drug development. He has more than fifteen years combined academic and industrial experience in pharmacology. His considerable experience in the drug development process has equipped him to develop state-of-the-art technologies.
Prior to founding Inoviem Scientific, Dr Eftekhari co-founded two other companies offering tailored drug development services. The partnerships he has built with pharmaceutical companies and academic laboratories at the international level have given him an in-depth understanding of the pharmaceutical industry's needs.
He holds a PhD in biology, with a major in pharmacology, from the Louis Pasteur University, Strasbourg.
Léone ATAYI
Leone has been patiently involved in structuring and building up innovative companies for the passed 15 years. She has put her academic knowledge in human resource management and her practical experiences in finance and strategy making at the service of multiple companies. Before joining Inoviem scientific Leone has been working with Polyplus transfection where she acted as CFO.
Dr. Daniel da Costa
Head of Business development
Dr. Da Costa joined Inoviem in 2013. He is an experienced international research project manager, having worked in Glasgow, Portsmouth and Montreal. He has served as project manager for Semia, an innovative business incubator, and Medeuronet, a company dedicated to offering innovative services to the medtech industry.
Dr. da Costa graduated from the Ecole Normale Supérieure in Lyon and holds a PhD in molecular biology and a Master's in innovation management from the University of Strasbourg.
Dr. Angélique Quartier
Head of biology and molecular pharmacology
Dr. Judith Eschbach
Head of in vivo pharmacology
Camille Torlotin
Assay development manager
Francois Louis
R&D scientist/ regulatory and quality manager
Justine Schneider
Head of proteomics and analytical chemistry
Pierre-Emile Rudolf
AI development and application manager
Dr. Johan Hoebeke
Retired CNRS Research Director
Dr. Johan Hoebeke has more than 250 publications to his name in peer-reviewed international journals, as well as eight patents. His research interests focus on physical chemistry as applied to molecular immunology and molecular pharmacology. Recently retired from his position as CNRS Research Director in the Department of Immunological and Chemical Therapeutics at the Institute of Molecular and Cell Biology at the University of Strasbourg (France), Dr. Hoebeke began his career teaching at the University of Kinshasa, Democratic Republic of the Congo. Later, he joined the research laboratories at Janssen Pharmaceutical in Belgium. On his return to academic research, he worked as Senior Scientist in the Pathological Biochemistry Department of the Free University of Brussels, Belgium. He also worked at the Jacques Monod Institute in Paris and then at the François Rabelais University in Tours. He spent a sabbatical period in the Wallenberg Laboratories at the University of Gothenburg, Sweden.
Dr. Hoebeke graduated with a BSc (1959) and PhD (1965) in biochemistry from the Catholic University of Leuven, Belgium.
Professor Jörg Wischhusen
Head of the Experimental Tumor Immunology Department of Würzburg University's Medical School
Since 2013, Prof. Wishchusen has served as Head of the Experimental Tumor Immunology Department of Würzburg University's Medical School. Currently, his research is directed towards tumor-host interactions in ovarian and breast cancer, with a strong focus on tumor-initiating cells and their ability to evade immunosurveillance. Strategies to relieve local suppression of NK and T cell effector functions by cytokines and other soluble factors are being investigated for their potential therapeutic use. Prof. Wischhusen trained as a biochemist at the University of Tübingen. After graduating in the field of molecular neuro-oncology, he became Research Group Leader at the Interdisciplinary Centre for Clinical Research in Würzburg, where he focused on mechanisms of tumor progression and immune escape.
Jean-Paul Ansel
Jean-Paul has more than 45 years of international banking and financing experience. His academic knowledge is rooted in Paris business school (ESCP) that allows him to grow his highly riche international experience through Scoa, Davum, MITSUI, Bank worms group, The Chase Manhattan bank N.A, Merill Lynch, HSBC Investment Bank, Commerzbank securities and Pennel Industries.
Jean-Paul is leading DMS group where his expertise has blossomed through acquirement of several companies all highly focused on human health, particularly personalized medicine.
Bioparc 3, 850 boulevard Sébastien Brant,
67400 Illkirch-Graffenstaden
Understand the MoA
Identify secondary targets
Advantages of a translational pharmacology approach
How translational pharmacology works
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Experience fine-tunes our strengths while we learn our weaknesses. Whether it's the end of a job, or a break-up, every ending is really a new opportunity masked in the finality of another phase. Some of us have a tough time get through the end of something and seeing it for what it really is - a new opportunity to grow and become better.
-developed a strategies for The Indie Chicks that will catapult us into the start-up stratosphere.
I could mire in the misery of failure and failed relationships, or I can use this persepective: There are no ups without the downs.
Keep your chin up and eyes forward. Keep working. Keep loving.
Endings are just another name for a new beginning.


text:
Trailer drops and pre-orders open for Command & Conquer Remastered Collection
Simon Walsh	- Mar. 11th 2020 4:30 pm ET Twitter icon @aSimonWalsh
Apps GamesNews
While it's far from what Microsoft has done with a brand new Age of Empires game, EA is following in the footsteps of many other video game companies by remastering some of its iconic games. Of its many titles, Command & Conquer Remastered Collection is comprised of Red Alert, Tiberian Dawn, and three expansion packs which include Covert Ops, Counterstrike, and The Aftermath. While the project has been public knowledge since October 2018, EA is starting to show us more of what is behind the curtain with a release date and trailer. Continue reading for more details.
Command & Conquer Remastered Collection inches closer to release
If you remember the old Command & Conquer games, you may recollect that graphics were easily distinguishable from others. Command & Conquer Remastered Collection does not change this, but instead focuses on making every asset and piece of footage 4K-ready.
Players are bound to also notice a remastered 7-hour soundtrack, revamped UI, and updated controls. Considering how much online multiplayer in games has grown over the years, it's unsurprising that the underlying framework has been rebuilt to support "custom games, 1v1 quick match, Elo-based matchmaking, leaderboards, replays and much more." A map editor paves the way fans to be imaginative and then show off their own creations.
"Our team has been working hand-in-hand with the C&C community since day one and we hope this transparent dialogue will result in the Command & Conquer Remastered Collection being a love letter to our fans," said Jim Vessella, Lead Producer at EA.
Command & Conquer Remastered Collection will officially debut on June 5. Three pre-order types are available now and include Digital Standard, Special, and 25th Anniversary editions. Each of which is priced at $19.99, $59.99, and $149.99, respectively. For those of us that don't want to wait three months to brush up on game mechanics can still find copies readily-available on Amazon, just don't expect 4K assets.
9to5Toys' Take
Growing up, Age of Empires was my go-to RTS game. Thanks to the release of Age of Empires II: Definitive Edition and an all-new version on the horizon, a spark for the RTS genre has been rekindled inside of me. As in the old days, I foresee both Red Alert and Tiberian Dawn becoming fallbacks for those times when I desire a break from Age of Empires. This reason alone is reason enough for me to pick up a copy of the Command & Conquer Remastered Collection.
9to5Toys: New tech/lifestyle product news. Up to the minute reporting on the latest technology and lifestyle product introductions, in-depth reviews and notable consumer price fluctuations…
Twitter icon @aSimonWalsh
Simon Walsh is an Writer at 9to5Toys. He worked at Apple for over 5 years. Get to know him more by following him on Twitter.
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Lot 1: International "Rhapsody" Sterling Silver Flatware.
Lot 2: (2) 19th C. English Sterling Silver Serving Spoons.
Lot 3: 19th C. English Sterling Silver Grape Scissors.
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Lot 5: 14K Yellow Gold & Diamond Cluster Ring.
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Lot 83: Caucasian Hand Knotted Rug.
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Lot 114: Group: Stinson 108 Aircraft Fuselage Parts and Wheels.
Lot 115: Chelsea Ship's Bell Clock.
Lot 116: (4) Tonner Doll Outfits, Memoirs of a Geisha 2006.
Lot 117: (15) Ashton-Drake Gene Doll Outfits.
Lot 118: (5) Limited Edition Barbie Fashion Model Dolls.
Lot 119: (3) Tonner 2006 Memoirs of a Geisha Dolls.
Lot 120: (15) Ashton-Drake Gene Doll Outfits.
Lot 121: (4) Barbie Pink Label "On Location" Doll Sets.
Lot 122: (8) Tyler Wentworth Collection Doll Outfits.
Lot 123: (5) Limited Edition Barbie Fashion Model Dolls.
Lot 125: Drop Crystal 7-light Chandelier.
Lot 126: Russian Gold and Lacquer Pendant / Brooch.
Lot 127: Russian Filigree Box with Palekh Lacquer Medallion.
Lot 128: Palekh Russian Lacquer Box.
Lot 129: Zverkova Palekh Russian Box.
Lot 130: Vanyashov Palekh Russian Box.


I just wanted to thank you and express how extremely appreciative we are of Big Sky Elite Basketball. My daughter's dream/goal to play basketball beyond high school is now a reality thanks to the experience and exposure she received this summer playing for Big Sky Elite.
After the summer circuit was over she began receiving emails from college coaches and we were shocked when she received her first official letter of intent prior to her junior year of high-school basketball.
Thanks for opening doors for my daughter!


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As Amada Cruz Exits, Phoenix Art Museum Acknowledges Lost Revenues
Nowakowski Leaves Latino Community Out of Latest Latino Center Effort
Laurie Notaro on Overlooked Women in History, Real Housewives, and Bringing Funyuns to Lit Lounge in Phoenix
Evie Carpenter
Evie Carpenter | September 23, 2014 | 8:00am
Chances are, you're familiar with Laurie Notaro. If not, just type her name into that little search bar above, and you'll find a smattering of pieces written by and about this hilarious bestselling author with a mouth like a 10-year-old sailor.
Notaro joins some of Phoenix's most entertaining storytellers on Thursday, September 25, for Lit Lounge: The Best of Phoenix Edition at Crescent Ballroom. We caught up with Notaro before she made the trip from the much cooler Eugene, Oregon, back to Phoenix and discussed everything from pus-colored crayons to her hatred for Alanis Morissette.
See also: Lit Lounge: The Best of Phoenix Edition Coming to Crescent Ballroom Sept. 25 (Tickets on Sale Now)
What occasion do you wish there was a greeting card for that there isn't? I would have to say, I wish there was a greeting card for Biggest Asshole of the Day, and I would buy 365 of them, and I would be able to give them out just by going to Safeway. Just by driving to Safeway, I'd be able to give them all out in a day.
Or "You could really use a bra, lady." I would like that greeting card as well. Where I live, I think I'm the only one here who wears a bra. A bra is your friend, not your enemy. It can only help you, it will never hurt you.
What are you most proud of? My dog is awesome. My dog is awesome because we took her to puppy class, and I took her to training for four different levels, and she has reached the good citizen award. Yes, I'm very proud of that. She can sit on command. I'm also very proud that she hasn't bit a small child yet. I'm very proud of that.
I do have to admit that we got kicked out of agility class because she stopped during two different tricks and peed on the course so we were not allowed to come back. That's frowned upon, apparently.
What are you most excited about right now? I am most excited about the book I just finished and the book that will be published in January 2016 [Her Horses Invariably Galloped]. It's historical fiction, so it's something very different for me. It was a vast undertaking, and it's about the female pilots who tried to make the trans-Atlantic crossing in 1927-1928. This was all pre-Amelia Earhart because she was literally the last person on the scene, and she actually did not fly that plane. These women were actually pilots, and their stories are incredible and amazing and jaw-dropping. So it was just the best thing I've ever done, and it was just an awesome experience to work on that book.
How long did it take you to research for that book? I researched it on and off for about four years and then two years consecutively. They were awesome women in the '20s, and just beautiful, and man, they had balls.
Everyday I would find stuff out that would make my jaw drop. And when you see these cockpits, they are at the most four or maybe four and a half feet wide. They're crazy, crazy tiny. And women were certainly smaller then. It wasn't like I had to fit my fat ass in that cockpit, but still, it was like you were literally rattling above the Atlantic in a coffin. It was crazy small.
If you could name a new crayon, what would its name be and what color would it be? I have to admit that the first ting that pops into my head is pus. It would be a milky yellow, and you could use it for zombies, coloring pictures of zombies and mortal wounds and operations gone terribly wrong. Gangrene. It could be for all the gangrene coloring books. I will fully admit that is disgusting, but that how my mind works, I guess. I'm ashamed of that. I'm sorry I couldn't say "daisy" or something like that.
What are you reading right now? I am in the middle of a book about women who fought in the French Resistance -- more women who we don't know about. There were 230 of them, and they were women who were in France in the occupied zone who were fighting against the Nazis. There were 230 of them who pretty much all went to prison together and then were all sent to Birkenau and Auschwitz together. And I think 40 of them survived. Such an uplifting book! What are you reading, Laurie? Oh, just about the rise and fall of the Third Reich.
It is called A Train in Winter. It is a phenomenal book. It's a book that should be taught in every women's studies class.
You're 5 years old, and you have a babysitter but she's fallen asleep. Also, you don't have a TV. What do you do? Is she drunk? If she's drunk, I would draw on her. Let's say she's drunk. I would draw bad things on her. That's exactly what I'd do. And in Sharpie so it would be there for a while.
If you never had to hear one song again, what song would it be? Anything by Alanis Morissette. It could be any song. I could pull my own fingernails out to distract myself from the misery that's going on audio-wise.
What is the first thing that came to mind when I say paisley? Is there something called the paisley pig or the Paisley Violin or something? I think it's a place in downtown Phoenix. I've never been there, but I have no other context spot for paisley.
I picture a little pig, standing up on its hind legs, all paisley-ized, playing a violin -- about to become bacon.
In the last 24 hours, what is something you were glad no one saw, or someone did see, but you wish they hadn't seen? Oh, I tripped over the same carpet three times yesterday. That carpet's going to kill me. I'm going to trip down the stairs and then trip on the carpet, and then I'll be dead.
I also did fart in the driveway, but nobody saw that!
Do you have a TV show guilty pleasure? Yeah, I do. Any of the Real Housewives. I prefer New York or New Jersey. New Jersey especially because it's a "what if" kind of program for me. That's what I probably would have turned into had my parents stayed in Brooklyn.
See, if I hadn't moved to Phoenix, I would probably be going to jail for fraud because of my baboon husband who won't pay the government. I'd be wearing leopard skin and some tight leather, and that's not a good look for anyone.
If you could take a selfie with one person, dead or alive, who would it be? Probably Janis Joplin because she has worse hair than me, worse skin than me, and worse teeth than me. But she rocks! She pulled it off; she rocks.
On average, how many hours per week do you spend on Pinterest? That's easy; it's part of my daily ritual. It usually takes about 20 minutes, so 7x20, whatever that is.
But I only pin three things: I pin clothes, recipes for bread, and recipes that look like vomit. There are a lot of recipes that look like vomit. How do people not know that? It's like you made vomit! You put vomit on noodles, you put vomit on a bun. You made barf in a crockpot, which I can actually do in five minutes. It took you eight hours to make that barf. It's disgusting!
That's my most favorite [Pinterest] board.
If you had to pick a pseudonym, what would it be? That may take me some time to think about. Oh, I know -- J.K. Rowling. I'd like to pay off my taxes -- J.K. Rowling. It would be the shittiest book ever by J.K. Rowling.
We heard a rumor you were going to throw Funyuns into the crowd. Will you have Funyuns at Lit Lounge? Sure, I'll bring Funyuns, Twinkies, whatever people want. Absolutely! Funyuns are great, and they are the most disparaged snack food ever. I mean, listen. There can't be any fat in them because they're not real -- they're chemicals plus salt. And they're crunchy, and they're in rings, so you can wear them.
And that was my thing during the last book. I probably ate, I'm thinking, 20 bags of Funyuns. That was my thing. I was like I'm not going to be hungry when I'm writing this book. So I ate a lot of Funyuns.
What are you doing next? I am coming to Lit Lounge, which I am very excited about, and I am researching a new book, which takes place in Phoenix. I'm very excited about that, so I'll be spending a lot of time in Phoenix this winter. It's another historical fiction book, but it's about something that actually happened.
Is there one place you really want to make sure you visit when you come to Phoenix? Yes, Rosita's. Rosita's is my favorite place in the world. They do something magic to their re-fried beans, which gives them a bacony, smoky flavor. They make their own tortillas. They're awesome! So all my friends know, when I come to town, everyone knows we're going to Rosita's.
Laurie Notaro performs Thursday, September 25, at Lit Lounge: Best of Phoenix Edition at Crescent Ballroom, 308 N. 2nd Avenue. Doors open at 6 p.m., and the show starts at 7. Tickets are $10 and can be purchased at crescentphx.com.
Follow Jackalope Ranch on Facebook, Twitter, and Pinterest.
Evie Carpenter is a visual journalist. Using photography, videography, design, and sometimes words, she tells stories she hopes make a bit of difference in the world, even if those stories are in list form and include GIFs.
Twitter: @eviehollis
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Researchers from the University of Pittsburgh and Stanford University discovered that a supposedly inactive protein actually plays a crucial role in the ability of one the world's most prolific pathogens to cause disease, findings that suggest the possible role of similarly errant proteins in other diseases.
The team reports in the Proceedings of the National Academy of Sciences (PNAS) that Toxoplasma gondii—the parasitic protozoa behind toxoplasmosis—attacks healthy cells by first injecting them with pseudokinases, which are enzymes that have abandoned their original function of transferring phosphates. When the researchers engineered strains of T. gondii without a particular pseudokinase gene cluster called ROP5, the pathogen was subsequently unable to cause disease in mice—a notable loss of potency in an organism that can infect nearly any warm-blooded animal.
These results are among the first to implicate pseudokinases as indispensible actors in pathogen-based disease, said senior author Jon Boyle, a professor in the Department of Biological Sciences in Pitt's School of Arts and Sciences. Boyle coauthored the paper with John Boothroyd, a professor of microbiology and immunology in the Stanford School of Medicine. Boyle and Boothroyd worked with Michael Reese, a postdoctoral researcher in Boothroyd's lab, as well as Gusti Zeiner and Jeroen Saeij, former postdoctoral researchers under Boothroyd.
The Pitt-Stanford project suggests that the significance of these aimless enzymes to T. gondii could apply to pseudokinases in other pathogens, Boyle said, including the parasite's close relative Plasmodium, which causes malaria.
The ROP5, or rhoptry protein 5, gene cluster—so named for the specialized organelle rhoptry, which secretes them—belongs to a larger family of approximately 40 pseudokinases present in T. gondii. Once T. gondii injects ROP5 into the host cell, the parasite enters the cell and forms a protective membrane pocket, or vacuole, around itself to which ROP5 and other proteins attach. While the other secreted kinases are known to help disable or disrupt activity in the host cell, the ROP5 cluster, a kind of infectious ringleader, appeared to have a more dominant role in causing severe disease in mice than other virulence factors, Boyle said.
The team plans to further investigate the significance of ROP5 to T. gondii's survival within the host, Boyle said. In the PNAS paper, the researchers suggest that ROP5 has undergone multiple rounds of gene duplication followed by mutation of the individual copies. Thus, the authors propose, the ROP5 cluster may act like a genetic Swiss Army Knife, a multipurpose tool that allows T. gondii to adapt to and infect its famously wide variety of hosts.


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Hit Song Breakdown: Yellow – Coldplay
By NewRockstarPhilosophy • June 9, 2008 • Digital Music, Hit Song Breakdown, Music Business Commentary, Music Career, Music Marketing, Music Publicity, Songwriting
On this weeks Hit Song Breakdown we tackle Coldplay's inaugural hit: Yellow
This song is the reason Coldplay are the biggest band in the world.
Their first single "Trouble" was well received but it was nothing compared to Yellow.
So why was Yellow such a massive hit?
There are a few reasons.
Timing – D'ya remember the year 2000? Although the big scare was Y2K, most of humanity was really scared of Boy Bands ruling the earth. The Backstreet Boys and N'Sync were the kings of main stream charts. Rap Rock was becoming homogenized and boring, and Napster was starting to eat away at record sales. And then like a shot to the heart- Coldplay came along. Yellow was destined to be a hit.
The Video – Awww it's a non imposing young male walking on a beach in slow-mo and yet singing regularly…. It's GREAT! And such a breath of fresh air from the other garbage on MTV. BUT A HUGE ADVANTAGE YELLOW HAD WAS= It also was 1 of the 11 Music Videos allowed on MTV after 9/11.
The Music!!! And what amazing music it was.
Yellow is an awesome song. Haters be damned. Lets see you write a song with the honesty and Hooky-ness of Yellow. huh? huh? thought so.
Yellow's opening Riff is Huge! Your singing it in your head already. It's more infectious then PerezHilton. And guess what that riff is? It's the Chorus. Yes. The guitar part IS the chorus, or you could say that this song does not even have a chorus, it has an awesome Riff that is ridden from the start of the song to the end.
A couple of years ago Coldplay was on VH1's Story Tellers and Chris Martin spoke about how during the writing of Yellow the lyrics were missing something. The song had been written and it was ready to be recorded but it was missing a key element. A Lyrical Hook.
"Look at the stars, look how they shine for you, and everything you do……." – was the original line. Chris Martin still needed something. So Coldplay were jamming out the song and the yellow pages were laying around and thats all it took kids. A worldwide hit was born. "And they were all yellow" —- which by the way doesn't make sense, right?
So other than the Lyrical hook, and the Guitar hook, and the Drum hook (they are huge!), the LYRICS are unbelievably accessible. Everyone from your kid sister to your Grandma can dig these lines. WHY??? well….
It's a song about YOU.
It's a song about YOU and LOVE.
It's a song about YOU and LOVE and how BEAUTIFUL YOU are. Awesome.
Look at the stars,
Look how they shine for you,
And everything you do,
Yeah they were all yellow,
I came along
I wrote a song for you
And all the things you do
And it was called yellow
Oh yeah your skin and bones
Turn into something beautiful
D'you know you know I love you so
You know I love you so.
This song is for Females, and typically hit song lyrics are aimed at Females. If you get the girls you have to guys, because the guys always follow the girls.
Finally there is one more factor that puts Yellow above so many other Top 40 songs. Its HONEST.
You BELIEVE the band, you BELIEVE the SINGER, you BELIEVE the SONG.
YOU BELIEVE YELLOW.
[youtube=http://www.youtube.com/watch?v=qI8I6qcxWyU]
The bottom line: Yellow is a hit because it contains 3 CHORDS and the TRUTH. Just like every other song you love.
Lyrics Baby, Lyrics,
Arms UpArmsUpcoldplayHit SingleHit Song BreakdownHit SongwritingHooverNew Rock Star PhilosophyNew Rockstar PhilosophyNewRockstarPhilosophy.comPembertonPerez HiltonThe New Rockstar PhilosophyTroubleViva La Vida Or Death And All His FriendsVoynoYellow
John Mayer on Songwriting and a Career in Music
Jermaine Dupri Talks About The Future of Music
Reply	Michele June 10, 2008 at 7:07 am
Great lines!
A big Ciao from Italy


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Rachmaninov : Remembering Russia
Thu 5 Feb 2015
A cheerful Finnish spring meets the high summer of Norwegian romanticism as the BSO welcomes back the 2009 Leeds Piano Competition finalist Alessandro Taverna.
Conductor Joshua Weilerstein
Piano Alessandro Taverna
Sibelius Spring Song
Grieg Piano Concerto
At just 27, young conductor and "revelation on the podium" (Corriere della Sera) Joshua Weilerstein is going places fast. With most of Scandinavia's finest orchestras under his belt not to mention the New York Philharmonic, Sibelius and Grieg should put him in his element. To complete the programme, Rachmaninov called his Symphonic Dances his "last spark", filled with backward glances to Russia and his earlier works.
Pre-concert Foyer Performance 6.30pm
Ensembles from Bristol University Music Society perform.
The Victoria Woodwind Quintet:
Ligeti 6 Bagatelle
Milhaud La Cheminee du roi Rene
Ravel Pavane pour une infante défunte
Malcolm Arnold Three Shanties
The Bristol Brass Quintet:
Bizet Carmen Suite
Rossini Largo al factotum
Haydn War march of the priests
Inside The Music talk
The Lantern, 6.25pm, free with a concert ticket
Jonathan James looks into moments in Rachmaninov's Symphonic Dances with demonstrations from the piano.
Book for three or more International Classical Season Concerts at the same time and save up to 30%
See all the concerts in the series
We'd love to hear your memories of the performance. Add your photos, reviews and memories via Twitter using the hashtags: #colstonhall and #show56322 and they will appear on this page
Joshua Weilerstein
Born in 1987, Joshua Weilerstein is one of the world's most promising and sought after young conductors, first attracting international attention when he won both the First Prize and the Audience Prize of the 2009 Malko Competition for Young Conductors. He has since conducted and has been re-engaged by many of the major Scandinavian Orchestras, and has served as Assistant Conductor of the New York Philharmonic. In 2013, he returned to conduct the Los Angeles Philharmonic where, previously, he served as a Dudamel Fellow to the orchestra.
Joshua Weilerstein graduated from the New England Conservatory in 2011, where he received his dual Master of Music degrees in orchestral conducting and violin. In 2007 the Simon Bolivar Youth Orchestra of Venezuela (SBYO) engaged him as a violin soloist, and shortly afterwards asked him to join the first violin section, making Joshua the ensemble's first non-Venezuelan guest member. In January 2010 he made his guest conducting debut with the SBYO.
Alessandro Taverna
Reviewing multi-prizewinning Italian pianist Alessandro Taverna's Bronze Medal performance at the 2009 Leeds International Pianoforte Competition, Tim Ashley of The Guardian said: "Remember his name, I suspect we shall be hearing much more of him in the future." He has continued to impress reviewers and audiences alike, with The Independent declaring him as "the natural successor to his great compatriot Arturo Benedetti Michelangeli".
Alessandro has performed throughout Italy, Europe and America, with orchestras such as the Chamber Orchestra Kremlin, the Salem Chamber Orchestra, the London Philharmonic Orchestra, Royal Philharmonic Orchestra, Minnesota Orchestra and The Hallé, and has recorded for Radio Classica in Italy, and for Classic FM Radio in South Africa.
www.alessandrotaverna.com
Rachmaninov : Remembering Russia / Shows / Colston Hall #colstonhall #show56322 http://t.co/AMJpN8Bfoj
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Bristol International Classical Season
Tue 30 Sep 2014 - Wed 10 Jun 2015
Colston Hall / Classical
Trinity Centre / Rock and Pop
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Westpac is trialing Host Card Emulation (HCE) mobile payments and is the first bank in New Zealand to do so, according to an announcement from the financial institution.
Westpac is using Carta's HCE technology during the three-month trial, which is only compatible with Andriod smartphones running the latest software update.Westpac's Chief Product Officer Shane Howell said the trial is the first step towards a completely digital wallet in New Zealand, and is expected to be available to customers early next year."We already use our smartphones to organize so many aspects of our lives, so using them to make payments is just a natural extension of this," he said in statement. "This is the first of four key components we are looking to develop that will make up a digital wallet for Westpac customers.
Developed in partnership with global payments innovators Carta Worldwide, Wespac said security is a key feature of the digital wallet.
Carta Worldwide is an international leader in digital transaction technology, specializing in mobile and emerging payments. Carta's next-generation platform is specifically architected to meet the complexities of the evolving payments environment. Leading innovation in advanced solutions for tokenization and cloud based payments, Carta excels where legacy systems are challenged, delivering end-to-end solutions that bridge the gap between financial and mobile systems.


The Jaguar I-PACE is on a winning streak! After taking home the title of 'German Car of the Year', the I-PACE has been crowned 'Car of the Year' along with 'Best Alternative Fuel Car' at the 'Scottish Car of the Year Awards 2018'.
The I-PACE is Jaguar's first all-electric performance SUV that brings style and sophistication to the world of electric cars. Thanks to its winning combination of opulent luxury, superior performance and next-generation technology, the I-PACE is positioned firmly at the forefront of the electric vehicle revolution. Along with a 292-mile range, the I-PACE delivers 696Nm of instant torque and is capable of 60mph in 4.5 seconds, offering the performance of a sports car that is truly exhilarating and rewarding. Using a 50kW charging station, the I-PACE can achieve 0-80 percent battery charge in just 85-minutes; or alternatively re-charge your I-PACE with a home charging AC wall box (7kW) – suitable for overnight charging.
Ian Callum, Jaguar Design Director, said "As a Scot, it is a huge honour to be awarded Scottish Car of The Year for I-PACE. Development of the I-PACE started many years ago, with design and engineering working closely to achieve a vision to create not only the best electric vehicle but the best car, all round - and this award really affirms that".
Rawdon Glover, Jaguar Land Rover UK MD comments: "with luxury and capability at the heart of its design, along with one of the most advanced zero-emissions powertrains ever fitted to a production car. The I-PACE is an electric vehicle that's practical for everyday use and we look forward to seeing even more on the road".
Book your test drive today at Park's Jaguar Ayr or Inverness and experience the exhilarating performance of the All-Electric I-PACE.


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COVID-19UK News
Covid cases rise as one in 37 has virus in Britain
COVID-19UK News October 17, 2022 October 17, 2022
More time and more data will help clarify whether infections are rising or falling in these areas…reports Asian Lite News
The latest estimates from the Office for National Statistics (ONS) suggest one in 37 people in the UK has coronavirus, a rise from one in 50 the week before.
Experts warn of a "notable rise" in older people in England and Wales.
They say vaccines are the best defence against the virus and urge people aged 50 and over and others eligible for booster jabs to get them. There are fears of a flu and Covid "twindemic" this winter.
US govt announces plan to end Covid-19 emergency declarations
Sarah Crofts, deputy director for the ONS Covid survey, said there was a need for close monitoring as we moved through colder months.
She added: "Infections have risen again across much of the United Kingdom, continuing the pattern of steady increases seen over recent weeks, although Scotland and the North East of England had uncertain trends in the latest week."
More time and more data will help clarify whether infections are rising or falling in these areas.
The latest ONS figures suggest Covid is infecting around 2.7% of the population – around 1.7 million people overall.
But the proportion of people infected is higher in older age groups. In people aged 70 and over around 3.7% have the virus in England.
Dr Mary Ramsay, from the UK Health Security Agency (UKHSA), said it was "particularly worrying" that the number of infected older people was rising "because they are the age group that are likely to get severe Covid and go to hospital."
She said people over 50 should be encouraged to get their boosters to protect them and help prevent them ending up in hospital, but also to protect the NHS from pressures that are likely to get worse over the winter.
Everyone in England aged 50 and over is now able to book a Covid booster and flu jab.
Over-50s in Wales and Northern Ireland are also already eligible for both jabs. The Scottish government says that it will begin inviting 50 to 64-year-olds soon. The number of people in hospital with Covid has also been rising in the last few weeks.
As of 12 October, figures show there were 10,608 patients in hospital who had a positive coronavirus test.
That was up 10% on the week before but still far below the levels at the beginning of the pandemic.
Around two-thirds of patients in hospital who test positive for Covid are being treated primarily for other things.
But they may need to be isolated from other patients, putting extra demand on hospitals.
ALSO READ-New Covid variant BQ.1 behind 1 in 10 cases in US
Tagged: covid UK
Sunak marks 100 days as UK PM
Rishi in trouble as recession looms
Royal Navy gets a mine-hunting 'mother ship'
Nation-wide rage against BBC by UK Indian Diaspora
Biden says 'no' to sending F-16 jets to Ukraine
EVENT: India UK Achievers Honours 2023, London