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Cancer Experts Talk Transformation in Treatment and Care
Paul Caine | Meredith Francis | February 24, 2016 6:38 pm
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Meredith Francis
With President Jimmy Carter's seemingly miraculous recovery from a metastatic melanoma that had spread to his brain after treatment with a newly approved drug, it's tempting to hope that medical science is finally winning the battle against this so-called "emperor of all maladies."
So what is the state of current medical research and treatment for the many varieties of cancer that plague us?
Steven Davidsen, vice president of oncology discovery at AbbVie, has specialized in cancer research for the past 20 years. He says that while surgery, radiation and chemotherapy are still largely used in cancer treatment today, there's been significant progress since he's studied cancer.
"It's actually a pretty amazing evolution," Davidsen said. "Historically we have treated cancer by way of slash, burn and poison – that is surgery, radiation and non-specific chemotherapy. What we have tried to do in stepping forward from that history is to try to distinguish characteristics between cancer cells and normal cells and come up with agents that are more selective or more targeted to those differences."
One treatment being studied involves using the body's immune system to target cancer. Davidsen said in the last 10 years, researchers have been getting excited about this kind of treatment, which a New York surgeon first got clues about in the 1890s. Three immuno-oncology agents have been approved, with more on the way.
"What's interesting about them is they are not specific to a specific cancer type, in that they have shown activity in melanoma, they've shown activity in subsets of lung cancer and kidney cancer and are being studied across the board," Davidsen said. "Is it a complete panacea? Probably not. But have we made substantial progress in a new pillar for cancer treatment? No question."
Davidsen said researchers are now trying to understand how far this type of treatment will extend to other types of tumors.
Cancer cells in culture from human connective tissue, illuminated by dark-field amplified contrast, at a magnification of 500 times. (National Cancer Institute)
Dr. Francis Giles is a professor and chief of the division of hematology/oncology at Northwestern University's Feinberg School of Medicine. He's been in the field for nearly 30 years and also said that, while radiation and chemotherapy are still most often the best option, patients could one day see more targeted treatments like immuno-oncology.
"The reason it's very exciting is it may be the first page, but we don't really understand yet how big the book is," Giles said. "And we don't yet understand, although we are beginning to … if you tell the immune system wake up, get stronger and while you're at it, get stronger specifically against this malignancy."
Giles said that cancer researchers can be optimistic, because their optimism is now based in scientific reality.
Scientists are also looking at T-cells, a type of white blood cell, to see if they can be modified to recognize and attack proteins specific to tumor cells. While this type of treatment hasn't been approved, Davidsen said it has shown some "dramatic" results in both children and adult leukemia patients.
Davidsen said the big moment in cancer research will come when we're able to prevent or detect cancer earlier.
According to Giles, the most promising part of recent cancer research is that scientists are beginning to understand the way cancer cells work.
"We have a very big advantage in cancer, and that's not a phrase you hear often," Giles said. "The advantage is that cancer cells are crazy. They divide too often, don't die when they should and they spread where they have no business. And the point is, very obviously, a crazy cell has a code … what we have now is the technology to compare and contrast. And the more you do that, the more you can figure out what is driving the crazy cell and what drivers do I need to turn off to stop the cancer's progress."
Dr. Francis Giles, left, and Steven Davidsen on "Chicago Tonight."
Upcoming event: How We Treat Cancer
An upcoming health and wellness event at Matter Chicago (222 W. Merchandise Mart Plaza, #1230) outlines the history of cancer treatment and outcomes. Learn about best practices and the next generation of cancer treatments. The event takes place from 6-7:30 p.m. on Thursday, Feb. 25. Registration begins at 5:30 p.m. A suggested donation of $5-$10 is recommended. For more information, visit the event website.
Oncologist's Book Guides Patients, Family Through Cancer
Nov. 12. 2015: A cancer diagnosis unleashes a whirlwind of emotions and questions for patients and their loved ones. To help them navigate through this trying time, Dr. Ranjana Srivastava, an oncologist and former Chicago resident, shares her knowledge in a new book, "A Cancer Companion: An Oncologist's Advice on Diagnosis, Treatment, and Recovery."
Report: Processed Meat and Red Meat Can Cause Cancer
Oct. 29, 2015: Hot dogs, bacon and other processed meats can cause cancer as well as red meats, according to a new report by the World Health Organization's research division. How much is too much? We discuss the findings with a dietician and a professor whose research focuses on meat sciences.
New Guidelines for Breast Cancer Screening
Oct. 26, 2015: The American Cancer Society has issued new guidelines for women at "average risk" of developing breast cancer, raising the age it says they should start regular mammogram screening from 40 to 45. We discuss the changes and how women should go about determining their own levels of risk with Dr. Carolyn Bruzdzinski and Dr. Kent Hoskins.
'Cancer: Emperor of All Maladies'
March 30, 2015: Tracking the history and treatment of cancer from ancient Egypt through today: we talk with Dr. Siddhartha Mukherjee, author of the book The Emperor of All Maladies: A Biography of Cancer, about a new three-part documentary produced by Ken Burns that begins airing Monday, March 30 on WTTW11.
Feinberg School chicago
northwestern university medicine
Francis Giles
Steven Davidsen abbvie
genomic testing cancer
stem cell cancer


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American actress Bex Taylor-Klaus leaked nude sexy photos
Star of the TV series "Scream" and "Arrow", Bex Taylor-Klaus has just had the nude photos below leaked online.
As a pious Muslim man this may be the best celebrity leak we have seen so far, for Bex Taylor-Klaus is one handsome woman completely lacking in any revolting aspects of sinful femininity. In fact, from behind with her hair slicked back Bex could easily stand in for one our beloved bacha bazi (dancing boys).
Of course the moronic infidels will point out that Bex Taylor-Klaus is a lesbodyke, and that she is even suckling on some girl's sin slit in one of these leaked pics.
Bex Taylor-Klaus (born Rebecca Edison Taylor-Klaus; August 12, 1994) is an American actress. She is best known for the roles of Bullet on The Killing, Sin on Arrow, Lex on House of Lies, Audrey Jensen on the Scream series of the eponymous franchise, and the voice of Katie "Pidge" Holt on the Netflix series Voltron: Legendary Defender.
Taylor-Klaus was born in Atlanta, Georgia, to a Jewish family. She began acting by performing Shakespeare in an after-school program while in the 3rd grade, and it became a consistent part of her extracurricular and summer activities. She performed in her high school's improv troupe. Working with friends, she also started a Junior-High Acting Troupe to train young actors. In addition to drama, Taylor-Klaus was an all-around athlete: she was the starting catcher on her high school's varsity softball team while a freshman, and also played 3rd base. She has two siblings; Syd Taylor-Klaus and Josh Taylor-Klaus. In mid-2012, Taylor-Klaus moved to Los Angeles to pursue an acting career. While she was in Los Angeles, she attended Bridges Academy.
Her first notable professional role was that of Bullet, a homeless street-wise lesbian teen, on the third season of the television drama The Killing on AMC, which aired in 2013. Writing about playing Bullet, she said that "to be an actor is to want to visit the dark places that humans strive so hard to stay away from." Currently, Taylor-Klaus is starring in the role of Audrey Jensen, a bi-curious person, in MTV's Scream. She also stars as Katie "Pidge" Holt in the Netflix series Voltron: Legendary Defender.
In November 2016, Taylor-Klaus came out on Twitter, saying: "hello my name is bex and yes the rumors are true I am v gay."
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The Steelers have won the Super Bowl six times and the S&P 500's average return for those years was a stunning 26 percent, according to an analysis by Capital IQ, a provider of business and financial information solutions.
"That gives us a lot of reasons to root for the Steelers. … I can't imagine why anyone would root for the Packers," says Jimmy Haslam, minority owner of the Pittsburgh team and president and CEO of Knoxville-based Pilot Flying J, the largest travel center operator in the country.
Haslam, being the savvy businessman that he is, doesn't buy into the Super Bowl theory.
"I cannot believe there's anything to it," he says.
If the SBI doesn't do it for you, there are other exotic market indicators you may want to consider, like the "Butter Production In Bangladesh" theory.
Steelers' Super Bowl Win Better for Stocks?


If you missed it, Freebird Games' To the Moon is a fantastic experience that saw a mobile release a few years after debuting on PC platforms. Check out Shaun's review for it. I don't think I'll ever forget my experience with it when I played it on Steam a long time ago. In fact just hearing the main theme play in the Vlog from Kan Gao above is reminding me of the story and the fantastic characters. If you enjoy narrative driven adventures with memorable stories and lovely characters, you need to play To the Moon.
Kan Gao also says that production on the next game from Freebird Games has also begun. I'm looking forward to seeing this when it releases. I hope Freebird Games port their other games to mobile soon because more people need to experience the music and stories from these games.


Adaptive Planning was recognized for the second consecutive year as a top emerging company in the Global Silicon Valley that is demonstrating significant market traction and pursuing game-changing technologies in enterprise and SaaS computing.
The AlwaysOn Global 250 winners were selected from among thousands of domestic and international technology companies nominated by investors, bankers, journalists, and industry insiders. The AlwaysOn editorial team conducted a rigorous three-month selection process to finalize the 2011 list.


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Approximately 2000 children and youngsters from Orange Walk Town and surrounding villages were treated with goodies from the Orange Walk Town Council Today. The Fort Cairns was jam packed and buzzing with activity to keep the attendees entertained. Lots of giveaways and treats were given and according to Mayor Kevin Bernard, while their funds were limited they incorporate Christmas cheer as a yearly tradition.


Vijay started out with theater in Hyd with Sutradhar and later studied acting at FTII, Pune, and also did some corporate and short films. A short film "SHOR" was a massive hit at the festivals directed by Raj Nidimuru and Krishna DK(directors of "99", "Shor in the city") "Chittagong"- Vijay s debut film.
"Monsoon Shootout" - Vijay plays the lead in the Hindi feature film directed by Amit Kumar,(director of the short film "The Bypass" which was internationally acclaimed and won awards at London film festival and Milan film festival and showcased at Baftas) and produced by Anurag Kashyap and UK Based Yaffle Films. The film is in Post-production stage.
"Rangrez", plays one of main leads of the Hindi Feature film, directed by Pryadarshan, produced by Vashu Bhagnani s Puja Films. The film is in Post production stage.
Before moving to Mumbai in 2007 Yashashwini was a free lance graphic designer and assistant director.


I am posting this for general information for all. The reason is because I have found (locked) threads which are indicating that you cannot use Ghost to restore your system drive (C) to a new computer with different hardware.
This is absolutely not true. You absolutely can use Ghost to restore to a computer with different hardware. I've done it several times and it absolutely does work. Therefore I am posting this to hopefully help dispel any confusion. My last restoral was to a different computer with radically different hardware including a much higher end mother board, going from single core CPU to multi-core and basically everything about this system was far different than my previous hardware.
Now it may be true that Symantec may not officially support it but it absolutely DOES work.
Allow me to explain the process in a bit more detail. If it helps let me mention that I am a software engineer and I have a good in depth knowledge of the Windows OS.
When you are restoring to a computer with different hardware it is likely that your new HD will also be much larger. So here's the process. Note that I am writing this procedure centric to single partition system drives. If you have multiple partitions this process might need a bit of tweaking.
When you boot from the Symantec Recovery CD (SRD), select "Recover my Computer" and then select the appropriate image to restore. Note that you need to select "Filename" from the drop down menu and NOT "Date". If you select "Date" the options below will probably not be presented. When you select FileName your recovery points will probably not be visible so simply hit "Browse" and browse to your recovery point file and select the appropriate image. Then select the target drive to restore your image to (your new HD) and click "Next".
Verify recovery point before restore - optional and takes longer if checked but a good precaution.
Resize restored drive - not optional if you want to have the extra HD space available to you after the restore.
Restore original disk signature - see also Chapter 14 in Ghost user guide.
Restore MBR - many times optional but should be checked to ensure the MBR is correct. Likely mandatory in Vista.
In most cases you can recover from this by simply doing what is referred to by Microsoft as an in place upgrade. To do this simply boot from your Windows CD and select the upgrade option. Make sure and specify upgrade and NOT new. Also make sure that the path to upgrade Windows into is your existing OS path (typically C:\Windows).
By booting from the Windows startup CD and doing the upgrade option, you will force Windows OS to go through hardware discovery process again. It will then recognize your new hardware and install all the appropriate device drviers and whatever else is needed. In most cases this will update your recovered OS to work with your new hardware.
The reason the Windows startup CD is required is because that is the only way to force Windows back to an early enough stage to properly re-discover and set up your new hardware.
This is the same thing that happens when you uprgrade your OS from say Windows XP to Windows Vista.
NOTE 1: after doing this you will most likely have to re-download and install all Windows Critical updates as this in place upgrade will most likely undo any previously installed critical updates.
NOTE 2: if you have Windows XP and your new HD is larger than (I believe) around 130GB, the default XP CD will probably not recognize all your new space. There is a way to burn another XP startup CD which includes XP SP2 which can recognize the larger HD's. If you have this situation let me know and I can find the link for you.
NOTE 3: Many times when recovering your OS onto all new hardware, you will probably have to re-activate Windows. Microsoft is pretty notorious for requiring this and they do it to minimize risk of piracy. So don't be surprised if after this you might have to call Microsoft to get re-activated. Sometimes you can do this on your own (online) but other times you have to call them whereupon they will ask you some questions to verify your OS is not priated and they will then give you the Activation key.
So there is a fair amount to the process to restore to a system with new hardware but for many this is still far easier than the alternative which is reinstalling your OS and all applications.
Excellent Post, Allen. It should be made a "sticky"!
Nicely done Allen. I expect we'll be linking to your post.
Another thing I should mention is that I included Norton Ghost 14 in the post title (because it is the most recent version of Ghost) but this procedure works equally well for previous versions of Ghost. In fact all but the last system restoral I done was on earlier versions of Ghost.
Please forgive my ignorance but this could only work if the new computer does not anything installed on it at all, right?
I would have to assume it impossible to restore a windows xp pro sp3 recovery point set to a new computer which has, lets say, windows vista installed? When you purchase a new computer, is an operating system already installed by the manufacturer? Or does the computer come with a blank hard drive and is accompanied by operating system and driver diskettes?
Note that my computer was ordered for me from my place of employment and certain software I wanted (like Visual Studio 2005) was installed by a tech person so I have no idea how the box first arrived.
I would have to assume it impossible to restore a windows xp pro sp3 recovery point set to a new computer which has, lets say, windows vista installed?
No, it is quite easy to restore the image to another partition and use a boot manager to select which OS to boot.
I think Allen mentioned single partition system drives for this thread. Again, I am a novice. I only began working with Norton Ghost 14 a month ago and, as you know, have never restored my primary partition.
When a recovery point set is restored, does NG first wipe out the existing data on the partition before the restore? In other words, even if a newly purchased computer had windows Vista installed but my c: drive recovery point set had windows xp pro sp3, would the new c: drive be wiped out first and then overlayed with the restored system and data?
If you restored a Windows XP recovery point to the new C: drive, Vista would be wiped out. The information contained in the recovery point would overwrite the information on the C: drive. Obviously, you would not want to do that.
What Brian is saying is that it is possible to have more than one operating system installed on a given computer. By using whats known as a boot manager, it's then possible to selectively boot to the operating system of your choice.
I may be wrong, but I'm guessing that you aren't interested in trying that just yet.
No need to worry though. You can always recover files from your XP recovery points, so you don't need to restore the entire recovery point. Programs may be a bit more problematic because you won't be able to simply recover them; you'll need to resinstall in the new Vista environment (assuming they are Vista compatible).
Let me add a couple of points to this. Obviously when you buy a new computer it will have an OS already installed. You may or may not choose to use it however, that is a choice you can make. As Brubaker said, if you buy a system with Windows Vista and you have Windows XP on your current system you might not want to overwrite Windows Vista on the new system to replace it with XP. But you could do so if you wanted to. You have a valid license for XP which gives you the right to load it onto that new system if you so choose. The license is to you, not a specific system so as long as you are not trying to use the OS on more than one system you are allowed to do this.
You could just as easily have a different situation. You could have Windows Vista already and then buy a new computer also with Vista in which case it is likely an easier choice to get rid of the Vista installation that came on your new system and replace it with the one you already have a license for.
The other possibility (which is what I have done all but one time) is that you buy individual components and put your own system together (or pay someone to do it for you) in which case it won't come with an OS already installed. Most people don't do this because you can usually get a better deal by buying one as a complete system. But when (like myself) you have need or desire for special hardware or need the choice of specific components that make up your system, it is typically pretty difficult to find such a system already assembled.
Yet another possibility is when you are replacing certain components but not the entire system. Maybe you are upgrading just CPU or Video Card, etc.
Understand also that when you buy a new computer system with Windows already installed, the extra cost added on to the system for just the OS is very minimal - it is NOT like buying a full version of the OS seperately. I don't know for sure what the cost is but I've heard others say it is around $30. That sounds about right to me. Microsoft is willing to sell licenses for these OEM computers so cheaply because it gives them even more market penetration with new systems.
There is only one time I chose to buy an already assembled system and that is when I was actually lucky enough to find one I could order which had the very components I wanted anyway and it was then cheaper to do it this way. With the components that I want however it is very rare indeed for me to find an already assembled system that offers that choice.
Even in this case however I overwrote the OS that came on that new system with my own. For me it was an easy choice since I have a few hundred applications.
Sorry, forgot to mention the possibility of dual booting as Brian and Brubaker talked about earlier. My thread was centric to single partition system drives simply because that is what I have. Since I don't have a system drive with multiple partitions I added that disclaimer. Please do not interpret this to mean or imply that you cannot accomplish the same on system drives with multiple partitions.
I am not sure if you can restore the system drive image on to a new hard drive w/o overwriting what is already there. That may not be possible. What IS possible is if you have backup images which were done on a system which already has multiple partitions and you can restore that system with the same multiple partitions on your new HD. This is exactly what you have with your OS and EISA partition.
Single partitions just happen to be my area of expertise so someone else more familiar with multiple partitions can update my procedure with that in mind.
I see the confusion. Let's say your new computer came with a 500 GB HD and a single Vista partition. You can resize that Vista partition, down to 30 GB if you like. Then you will have 470 GB in which to create multiple partitions and have multiple OS and data partitions. My current computer has 15 independent OS.
But you are certainly correct. When you restore an image, the target partition is deleted immediately prior to the image being restored. If you restore an image of a NTFS partition to a FAT32 target partition, the FAT32 partition ceases to exist.
Are you saying then that you can take a backup image which was created from a system drive with only a single partition and then restore to a drive with a pre-existing OS without overwriting this OS? Essentially restoring the backup image to a separate partition on the new drive, thereby preventing the overwriting of data on it's current primary partition? If so, I would further assume that it is a minor issue to modify the boot sector to then allow you a dual boot option.
So say you purchase a new computer with Vista on it already. Now you want to restore an image created from a single partition system drive containing say XP, you could essentially resore XP to the new drive then modify the MBR to have a dual boot system?
This does not really surprise me if I have it right. There is usually a way to do all sorts of things which may not be the standard. I just wanted to clarify since I have never had occasion to try this before.
P.S. You actually have a system drive with 15 different OS's on it?!? Impressive!!
I can guess, one would be Vista, then XP, then Linux. What else pray tell?
Several WinXPs, 3 Win7, Vista, 2 Ubuntu, several DOS, a few BartPE, Image for Linux, Image for DOS in FreeDOS. Certainly enough to keep me amused. They are all on my first HD.
On a test computer I once had 250 bootable DOS OS. I taught my son how to keep copying the partition and I had a beer. He didn't mind the repetition.
I couldn't install Win98 on my main computer. The error was "not enough Memory". (I have 2 GB RAM). I have Win98 running in a Virtual Machine. Don't ask me why. I can't remember.
Are you saying then that you can take a backup image which was created from a system drive with only a single partition and then restore to a drive with a pre-existing OS without overwriting this OS?
Yes. As you have gathered, I'm keen on BootIt NG. I'd resize (smaller) the original OS partition to create unallocated space and restore the image to this space using the Ghost CD. BING would be the boot manager. Neither OS will share boot files so either can be deleted in the future without affecting the other.
very interesting analysis and presentation. grateful for your input on the following. i am using dell inspiron 1300 with os xp-2 with all current updates. i would like to change the existing hdd for an ssd. i have an external 40gb hdd available. question: how would i proceed to transfer the existing drive contents to the external hdd and then re-install to the new-fitted ssd.
Is the external drive the one you want to use to replace your C drive or the one which will contain the backup image? Windows does not support booting from external drive. If the SSD which will replace your C drive is an internal drive it is very straight forward.
Some people attempt to use Copy Drive and that can definitely work but there are some inherent issues people tend to run into because the Copy is being done from within Windows and Windows itself can cause problems with booting from the new drive.
The method I would always recommend is to perform your full backup on the C drive to a seperate backup drive and then simply use the Ghost Recovery CD to boot from. Then just follow the recommendations in my first post on this thread to restore your backup to the new drive.
I meant to ask what type of HDs you used when you did your restores to different hardware. Were they IDE to IDE and SATA to SATA? Did you try IDE to SATA?
When I used the Repair Install method I only tried IDE to IDE.
In the past I have done IDE to IDE, IDE to SCSI, SCSI to SCSI and SCSI to SATA (a couple of them more than once). I think I've hit every combination except the one you mentioned! But it really should not matter, by running the Repair install (in place upgrade) the OS is forced back to an earlier stage and will perform Hardware Enumeration from the beginning. It should then resolve all hardware changes and install all the appropriate device drivers, etc. And my last upgrade included much more than just a HD change - in fact everything about my system had changed radically. The only minor issue the last time was with the upgrade from single core CPU to multi-core CPU on Windows XP Pro. After the in place upgrade it still just recognized the CPU as single core but ALL other hardware was updated just fine. I am absolutely sure that I could have gotten that to work with little additional effort except that I was planning to upgrade to Vista right after that anyway so I did not bother messing with it further on XP. When I upgraded to Vista it resolved that last minor issue.
It really is very straight forward. For many like myself (with a few hundred programs) this is the way to go. The only drawback really is that you have to re-download all Windows Critical updates as these typically are "undone" with the in place upgrade. Minor price to pay for not having to reinstall everything.
Thanks. That really is fascinating.
Just a question on your single core CPU to multi-core CPU on Windows XP Pro. Did that new computer boot? Was the HAL changed by the Repair Install? I haven't read any information on HAL changes by this process.
Perfect timing dude! I was just getting ready to walk away from the computer and head off to bed!
Oh yes, it booted just fine. The absolute only problem was that it ran slower than it should have because it was only allowing use of but one of the 4 CPU cores.
I'm not sure about how the HAL changed though I assume it must have been, what I do know is that the hardware changes have always been resolved properly (with that one minor exception of multi-core CPU).
My experience started with Windows 95, 98, ME, XP Pro and finally Vista Ultimate on various hardware platforms. For each of these upgrades I had a significant hardware upgrade involved as well. FYI: I also had a few Ghost restorals with the SAME OS and just different hardware. This is on top of the typical hard drive failure which I have had a few times, one of which was triggered by a massive power surge which to my chagrin managed to ZAP my hard drive even through what should have been a pretty high end UPS system.
If you are wondering about all the HD upgrades, do you recall how SLOW IDE drives were in the old days? That is when I first upgraded to Ultra Wide SCSI but finally the cost of replacement for failed HD's caused me to switch to SATA..
do you recall how SLOW IDE drives were in the old days?
Yes. Especially when they got stuck in PIO mode.
Do you think it could have been using the old HAL? I guess we will never know.
My test computer is an old Pentium 4 model. It uses halacpi.dll. If I try halmacpi.dll, it won't boot. My main computer is a dual core Pentium D. I'm pretty sure it will boot with either HAL but I haven't tested to see if it is slow with halacpi.dll. I'll try that.
Edit..... My mistake, the Pentium D wouldn't boot with halacpi.dll.
It could well be the HAL but as you said there is no way to know for sure at this point. This was the only case I ran into where a bit of messing around would have been required to get past that last small hurdle. Seems pretty unlikely that a repair upgrade would handle everything so beautifully (at least 6-8 times) unless it was properly dealing with the HAL.
The 'technical' side of me kind of wishes I had solved that one minor mystery on XP before upgrading to Vista but oh well.


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Under §1031 of the Internal Revenue Code, no gain is recognized if an owner exchanges real estate held for business or investment for other real estate to be held for business or investment. Owners use an independent intermediary like PRE to facilitate an "exchange." If the owner trades into property having equal or greater value and equity, no gain is recognized on the exchange. If the owner trades down in value or equity, gain is recognized only to the extent that the owner "trades down" (and receives cash or other property, or has net relief of debt).
In contrast, owners who "sell" their property must recognize all of their gain. Owners sell their property if they actually or constructively receive the sales proceeds. Once their sale closes, they cannot exchange. They must recognize all of their gain even if they immediately reinvest the sales proceeds in real estate. NOTE: Owners who do not exchange with a qualified intermediary and unilaterally direct the escrow holder to use the proceeds to purchase new property do NOT effect a valid exchange, even if the owner never actually touches the funds.
Gains remain subject to significant tax rates. The federal rate on long-term capital gains (property held longer than 12 months) was reduced to 15% for sales or exchanges after May 5, 2003, but the portion of the gain that represents prior depreciation deduction continues to be taxed at 25%. If the property is held for less than 12 months, the federal tax rate may be as high as 35%. California imposes state income tax of up to 9.3% and withholding of 3 1/3% of the gross sales price for taxable sales by individuals. For example, a $500,000 gain on the sale of California depreciable property may be subject to approximately $150,000 in federal and state income taxes. The amount of taxable gain may be greater than expected if debt was added to the property or if the owner has a low tax basis from depreciation deductions or a prior exchange. In some cases, tax on the gain may exceed the net sales proceeds.
The main benefit of a like-kind exchange is TAX DEFERRAL. If no gain is recognized, the owner defers paying income tax on the gain. Gain recognition is postponed indefinitely until the owner disposes of property in a taxable transaction. No interest is charged on the tax deferral. Over time, a tax deferred may become a tax saved. During the owner's life, the investment of money that would have been spent currently on taxes generates a return. The cumulative return on this money may, at some point, exceed the amount of the tax! When the owner dies, recognition of gain is permanently avoided. The heirs take the property with a basis equal to its fair market value.
Form and substance distinguish a tax-free exchange from a taxable sale. The form of the transaction must be an exchange, including proper exchange agreements and contractual relationships between the parties. In substance, the owner must not have actual or constructive receipt of the sales proceeds. For example, owners cannot simply sell their property and direct the escrow holder to deposit the proceeds to purchase new property. These transactions are invariably treated as taxable sales under case law. The owner is not "exchanging" with any party and has constructive receipt of the sales proceeds through the escrow holder.
To avoid a taxable sale and reinvestment, owners exchange with an independent intermediary like PRE. The owner and PRE enter into an exchange agreement under which the owner transfers the old property in exchange for new property to be acquired by PRE. PRE completes the sale of the owner's property and uses the sales proceeds to purchase new property that is transferred to the owner. A qualified intermediary (i) enters into an exchange contract with the owner, and (ii) avoids actual or constructive receipt of the sales proceeds by the owner. The owner safely qualifies for an exchange under Treasury Regulations. See Treas. Reg. §1.1031(k)-1(g)(4).
In a simultaneous exchange, the transfer of the old property and the receipt of new property occur at the same time. The owner and PRE enter into an exchange agreement. PRE acquires the owner's property, sells it to the buyer, acquires the new property, and transfers it to the owner. These transactions are interdependent and close concurrently. If the owner exchanges with a qualified intermediary, the transfer and receipt of property is treated as an exchange. See Treas. Reg. §1.1031(b)-2(a).
In a deferred exchange, the owner's property is transferred before new property is received. The owner and PRE enter into a Deferred Exchange Agreement. PRE acquires the old property, immediately sells it to the buyer, and receives the sales proceeds. The owner identifies new property in 45 days after closing. PRE uses the sales proceeds to purchase one or more identified properties, transfers the property to the owner, and completes the exchange in 180 days. The IRS endorses this procedure for effecting a "deferred exchange." See Example 4 of Treas. Reg. §1.1031(k)-1(g)(8). The advantage of a deferred exchange over a simultaneous exchange is additional time. In a deferred exchange, the owner has more time to identify (45 days) and to receive (180 days) new property after relinquishing the old property.
PRE provides agreements and other documentation to effect a valid exchange. PRE maintains a complete "exchange file" for the owner. The importance of proper documentation cannot be overemphasized. In auditing a transaction reported as an exchange, the IRS focuses on the documents to determine whether a valid exchange was made. The IRS also examines whether the owner had actual or constructive receipt of the sale proceeds.
PPRE specializes in real estate exchanges. PRE is owned and operated by licensed California attorneys with many years of exchange experience. We are regarded as national experts on tax-free exchanges and are faculty members for the nation's premier exchange conferences. Although we do not provide legal or tax advice while serving as intermediary, we have a complete library of all Section 1031 cases and rulings. Copies of the legal authority relating to any exchange issue can be provided to you and your tax advisor so that you can make informed decisions.
Sales proceeds are held in secure accounts until needed to complete the exchange. Funds are held in accounts with Merrill Lynch, Bank of America and Citibank. Funds are wired to and from escrow accounts to ensure safety.
Various services are offered by PRE in connection with simultaneous and deferred exchanges. The cost for most exchanges is only $750. If more than two replacement properties are involved in the exchange, the added cost is only $250 per additional property. For example, if one property is exchanged for two new properties, the fee is $1,000 ($750 plus $250 for an additional property).See "Costs" for additional information.
PRE may handle special items in connection with some exchanges. For example, PRE may receive a carryback note from a buyer, or PRE may be involved in an exchange of property that is partially rented and partially used as the owner's residence. PRE and its affiliated companies engage in other special or complex transactions, including reverse exchanges. Any additional services are priced reasonably at fixed amounts or hourly fees.


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The Floating Battery
This Scarred Earth
A House to Let
L'Imaginaire Collectif De Marseille
In Praise Of Nests & Other Things
Thomas Savage
Type Public Park
Location Marseille
Value -
L'Imaginaire Collectif De Marseille (The Collective Imagination Of Marseille)
'L'Imaginaire Collectif De Marseille' explores the possibility of a new marketplace against the backdrop of a central and unofficial district which typifies the perception of the city it is located in.
The project proposes the re-imaging of the Noailles district. Nicknamed "Le Ventre De Marseille" ("The Belly of Marseille") for its embodiment of the cities national perception and similarity to a stomach squeezing the cities contents through itself – a large market and meeting place where the Marseillais/e business is conducted. The proposal comprises a sequence of retractable market stalls, cinemas and public service structures that respond to the shifting uses of the district. Designed as a system of architectural elements working in harmony rather than a holistic structure, the scheme uses the collective imagination of Marseille as seen through French cinema as a resource to enhance and magnify the image of the city.
Cinema is used to explore the long-established French love affair with film as a means of self-expression. By distilling and dissecting these films using hyper-accurate digital softwares and programming, the proposal re-combines their raw data of sound, movement and colour as a set of new cinematically inspired structures with the aim of creating an enhanced identity for Marseille that can help to foster an appreciation of the unique qualities of the city in its residents.
By using cinema to polarize the perception of Marseille it is hoped that some of the challenges posed by the cities negative image can be mitigated and its residents can feel a closer affinity with their greatest natural resource, their identity. Music: OK Ikumi
Simulating Society
L'Imaginaire Collectif De Marseille
Copyright © 2017 Thomas Savage


Read the story of Bailey the bookworm to your children and grandchildren and then make your own customized plush Bailey in their favorite colors!
- 1 PDF sewing pattern with instructions and pattern pieces to create a 12" plush bookworm.
- A printable copy of Bailey the Bookworm, short story for kids.


"Roads fragment landscapes and trigger human colonization and degradation of ecosystems, to the detriment of biodiversity and ecosystem functions. The planet's remaining large and ecologically important tracts of roadless areas sustain key refugia for biodiversity and provide globally relevant ecosystem services. Applying a 1-kilometer buffer to all roads, we present a global map of roadless areas and an assessment of their status, quality, and extent of coverage by protected areas. About 80% of Earth's terrestrial surface remains roadless, but this area is fragmented into ~600,000 patches, more than half of which are <1 km² and only 7% of which are larger than 100 km². Global protection of ecologically valuable roadless areas is inadequate. International recognition and protection of roadless areas is urgently needed to halt their continued loss". Science (December 2016).
Monika Hoffmann studied at the Eberswalde University for Sustainable Development and works at the Centre for Econics and Ecosystem Management as GIS expert on different projects related to nature conservation.


Look extra sweet in this sparkling selection of pineapple jewellery! Featuring shimmering rings, necklaces and earrings, you can create the perfect pineapple accessory for every occasion. Dainty cutout necklaces are the perfect accent to your signature style, while more detailed pieces feature gemstones and can be personalised with special birthstones to represent the people you love.


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Archive: This page is an article that has been imported from Model 1 as an archive. It may contain outdated information and perspectives which are not compatible with the current model. To read more information on this incompatibility visit this page.
The following is a description of Fe's directive emotional attitude.
1 Directive Elements
1.1 Shaming
1.2 Retribution
1.3 Leveling in the Truth
2 Under Stress
2.1 Violence
2.2 Manipulation
2.3 Cultism
Directive Elements
Shaming
Quite in opposition to the adaptive attitude, the directive attitude doesn't believe in grace; it believes in punishment and the fairness that comes with properly balancing emotional economies. It accomplishes this through the use of shame. Directiveness believes that individuals are only kept in order –and rightly aligned in their personal and societal perception– by a regulation of pride. It will take it upon itself to "put people in their place" if they are exaggerating their own self worth or diminishing the value of others of a higher tier than they. We see a directive attitude echoed in phrases such as "you don't talk to your elder that way", "you use the right honorifics", "that was a foolish mistake, now your reputation is ruined." To this attitude, a reputation is in large part a proper reflection of what you really are, as it reflects how your comportment is objectively evaluated. Outside opinion is considered legitimate feedback given to you by the culture; negative feedback is necessary as the eternal modulator of pride where pride is only warranted when the tribe acknowledges your abilities and value. Directiveness is both the enforcer and receiver of this shame, and will concede or yield when they measure that they were the one in the wrong. However, unlike adaptiveness which makes itself susceptible to exploitation, the directive attitude will always defend itself against unjust or unearned reprimand and will only take reprimand when they are in agreement with it.
Indeed, when a directive person agrees with the shame, it would rather take punishment deliberately than be the one economically in the wrong. It may actively ask for retribution so that it may face others again without shame; having paid their dues. Balance is to be restored and they want to stand on the right side of judgment's blade. There is also a physicality and combativeness in this directive attitude, where it may believe it's fair game to balance the emotional scales using a physical-to-emotional pain translation. It will want to teach others a very somatic lesson, imposing an emotional experience on others through the vehicle of pain. It's important to note that directiveness is not sadistic by nature, as causing injury is not itself the aim but instead it's the translation of emotional energies through the act. A higher motif arises from this physical channel, where a directive attitude will wish to lock fists with others to truly "level" with them. They may develop a philosophy that "You don't really know someone until you fight them" or "You only really know someone's heart once you cross fists with them." The frustration that is expressed through battle is seen by directiveness as catharsis and as evidence of the reality of hearts. In this sense, the directive attitude wishes to see –as clear as possible– what lies in the heart of others and may encourage or even invoke that reality out in order to understand the other person better.
Leveling in the Truth
This leveling happens not only at the physical level, but also verbally. The directive attitude is diametrically opposed to adaptiveness in this regard; wishing always to cut through facades and speak frankly the harsh truth of its opinion. Directiveness does not collapse upon hearing the truth, or cave under its pressure, but actually feels relief and a rebuilding of trust. It feels that only after the air has been cleared can anything true and lasting be formed. A directive attitude will compel the person to ask those hard questions, dig at the problem, expose the fraud, heartbreak or corruption and look at it directly with no compromise in attention. It seeks to establish respect through transparency, in feeling another's pain and letting them feel yours. Getting angry at them and asking them to get angry at you. Directive people will be suspicious of any love or friendship that lacks conflict; viewing such things as symptomatic of concealment and compromise. It understands human hearts to be a messy business and is content existing in eternal but necessary friction so long as it does not escalate to unethical levels or into genuine malice. Notwithstanding it's harsh outward comportment, directiveness is ultimately driven by ethics just the same as adaptiveness. It will still hold steadfast to its ethical boundaries, even if it appears alarming in the words it selects for communication.
Under Stress
But a person with a directive attitude can also experience a great deal of stress in life, transforming these philosophies and behaviors into more unhealthy forms. The following are some common behaviors that manifest when a person is directive and under stress:
When under stress, the initially honest and cathartic qualities of a directive attitude become exaggerated outside of proper ethical constraints. The impulse to put people in their place regresses into a vengeful desire to defame or humiliate others. What was once a desire to create equilibrium devolves into a desire to cause genuine suffering. The name of the game becomes domination rather than the arrangement of society into balance. A societal order is indeed enforced, but one where others are oppressed under the emotional and physical rule of oneself. Here this attitude becomes predatorial and territorial, using tactics of intimidation and engaging in a power dynamic. Under stress, morality is tossed aside and the person resorts to foul play in order to remain atop of the social hierarchy. They may become emotionally abusive and physically abusive. And while all people can experience anger or sudden violent outbursts, directiveness is more prone to a premeditated aggression for the purpose of establishing rule and control. We see directive attitudes often manifest in gang violence, where the same Ti-Fe handling that is used to gather people together is then used to pivot those people against others.
Another effect that emerges from directiveness in an unhealthy individual is a proclivity towards emotional manipulation. Their ability to persuade and charm through oration is channeled into an artform designed to deceive and attain an advantage over others. Sweet words will fall off their lips while far darker intentions rest beneath them. The person is often keenly aware of the sensitivities of others –how they tick and how they break– and will exploit these vulnerabilities towards their own gains. They may assert emotional control over their relationships, weakening their lover or family member's opinion of themselves through psychological manipulation and gaslighting. Through months or years of verbal onslaughts they will diminish the confidence of others and present their own opinions as absolute. And through the sheer force of their personality, they will mentally overpower those beneath them –inhibiting their willpower, mobility and life options. Similar to how adaptive people can create a suffocating dynamic of co-dependence, the unhealthy directive type will use their loved ones to secure their need for control, relevance and ego validation.
Cultism
But this tendency towards manipulation may not stop at the home. The directive personality may extend the scope of their ego across a far broader group or community, using their persuasion to press their perspective and invoke agreement from others. This leads not only to the formation of gangs and cliques but ultimately to the creation of cults. The Ti-Fe oscillation is tribal in nature, and this same tribalism can be used to facilitate communion or to create divisions and special sects with niche ideologies. We see this tendency expressed in celebrities such as FeSi Alex Jones whose followers share an opposition to a perceived network of government conspiracies. It can be seen also in FeSi Tom Cruise who is famously affiliated with the cult of Scientology. The directive person will surround him or herself with those of like mind, creating an in-group/out-group dynamic and reinforcing an aggrandized self-image. The person becomes manic, prone to narcissism and all manner of delusions. As can sometimes happen with the judgment functions, a closed system is formed where the individual is convinced that they understand all that needs to be known and proceeds to act out that truth in the world at the widest scale possible.
Retrieved from "https://cognitivetypology.com/index.php?title=Directive&oldid=554"


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Q: Cleaning OHLC data I need to clean some data and I want to know what the most efficient way to go about it. For the data I have i'm missing about 3 yrs of open data, its been replaced with all zero's. I would like to replace these zero by the value of the earlier close.

A: for i in range(len(df)-1):
    df.Open.iloc[i]=df.Close.iloc[i-1]

you neede dto assign for each open  the previous close

redpajama_set_name: RedPajamaStackExchange


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Torwolia är ett släkte av kräftdjur. Torwolia ingår i familjen Desmosomatidae.

Kladogram enligt Catalogue of Life:

Källor

Externa länkar

Gråsuggor och tånglöss
Torwolia

redpajama_set_name: RedPajamaWikipedia


American Idol Compilation Album Top 10: Songs revealed!
American Idol is always a source of news and business. Well, now they announced the songs for the Top 10 Compilation album of American Idol.
Are you going to buy the American Idol album?


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Added on July 13, 2012 Hannah Golightly Ayla Nereo , BeHeld , Daniel Steinbock , Elliott Smith , Hannah Golightly , Joanna Newsom , Miss Li
Ayla Nereo – BeHeld (self-released)
By Hannah Golightly
Can you fall in love with a sound? Can love itself be expressed in sound? Because if so, this is surely that sound.
"All my angels walk the earth," sang Daniel Steinbock on his recent EP 'The Blade', which Ayla Nereo collaborated on. Listening to BeHeld, I now know one of the angels he must have been referring to…
This record is the sonic equivalent of a mother soothing her baby creating inside them a feeling of love and security – of being held. It's a pretty girl set free and dancing in the sun across a field. It's a child delighted by playing outside and muddying her dress, so absorbed she is in playing in the grass. Gentle, lush, pretty but no pushover. A charmed life. Daydreams on a summer's day.
'Headin' North'… mid-song there's an unexpected turn on a tour through different dimensions that guides us beyond the curtain that defines time and space where we happen upon a Speakeasy as the journey continues it's endless intrigue. Like Midnight In Paris where the lead character finds himself wandering between different eras of Paris, Ayla leads us to the best parties seamlessly blending the present with the most tenderest musical moments of the past. And the whole thing is joyful. Satisfying.
Where other singers of her ilk fall down with their great ideas, crashing and burning on the rocks of nauseating tweeness overkill, Nereo leaves them all for dust with her charismatic gentle strength and the confident stride of her vocals. Her voice is certainly something special and rare, for it never misses a note, never frays and always glides in pure and true. And you can tell she means it.
Just when you get comfortable with knowing the terrain, the songs change offering up sights of ever-expanding new horizons and each one more beautiful and breathtaking than the last. If I was listening to this album on a train, I would probably recount that the scenery and weather had been especially pleasant that day, infused with the vibes of this soundtrack, that's how my mind would have painted it.
As a fan of Miss Li, I can recommend this to others who like that sort of thing. It's different to Miss Li, probably more diverse with the various genres that this essentially modern folk music encompasses. It's like a not-just-bearable but delectable Joanna Newsom's dream music. It's like Moldy Peaches minus the twee. It's like Elliott Smith minus the depression.
I am tempted to make an inventory of all the various musical instruments that are played on this record. Yes, it's complex, with multiple melodies, layered, textured, peppered with pared down moments and subtle cacophonies galore. Never a note wasted in spite of the long list of pianos, xylophones, hand clapping, trombones, double basses, harps, guitars… hang on a moment, were there tubas in there?
Campfire rounds singing with friends cosied by blankets, the fire light softening expressions, bringing peace.
What strikes me is that this record seems to be doing nothing especially new – this is no reinvention of the wheel happening here. But I don't care. Not when it sounds this inventive, fresh and modern. Folk is evolving. Now it has special effects that add to its authenticity and strikes at the heart of a stale scene, breathing new life into old shapes.
I am not typically a fan of vocal harmonising is music, probably because I have heard so many examples of it done badly. Ayla Nereo has completely changed my mind on that now. Her harmonies are perfect, unexpected, original and essential.
I could listen to this all day. It's not even a genre I spend too much time absorbed in, but forgive me if I go cheating on my steady boyfriend with this stuff.
Bright and light but build from strong substance. Lyrical mastery. You could go collecting bundles of wild flowers with these songs in your ears. You could lay around between sheets with your lover cuddling up to this music. You could make handcrafts at your kitchen table to this stuff. You could go for a walk along the beach to this sound. You could nurse a Skins style comedown to this soundtrack. You could hop over stepping stones on a stream with your children to this.
Pulsing thumping computerised beats take me by surprise. A radiant semi-explosion of brass band pipes up to join in. And who wouldn't want to join in with the catchy energy going on here? Vocal loop pedals remind me of Tuneyards, but in this context seem less jarring and more natural. Yeah, Ayla Nereo manages to make computers sound organic! And if that's not a sign of true artistic expression, then I don't know what is.
I'm subconsciously listening out for the inevitable weak link song or songs that every album has or at least the downer moment, the slip of the mood… I've got BeHeld on repeat so I missed the end, waiting for that moment but it never came. Is this really possible? I check back and can't believe what I've just heard.
BeHeld by Ayla Nereo is available to buy on download here.
One Response to Ayla Nereo – BeHeld (self-released)
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LucidTalk Poll
Dutch media slam referee Webb after Holland's World Cup final defeat
July 13 2010 06:24 AM
The Dutch media today called English referee Howard Webb a "chump" following his controversial display in Holland's 1-0 defeat to Spain in the World Cup final last night.
Webb issued nine yellow cards to Holland players, two of which were shown to defender John Heitinga, whose dismissal left Bert van Marwijk's men to fight out the final 11 minutes of extra-time with 10 men.
They could not see it out with Andres Iniesta firing home in the closing stages to deny the Dutch and hand Spain the world crown to add to the European Championship trophy claimed two years ago in Austria and Switzerland.
The general feeling in the Dutch press was that the best side won but that did not spare Webb from their wrath.
AD Sportwereld wrote: "The Dutch national team perished in the World Cup final - thanks largely to a chump of a referee.
"It was a riveting battle, emerging through the tension but the Philistines were helped by Howard Webb, a controversial referee from England.
"He hopped across the pitch, handing out cards, each time preceding the act with an irritating address of the culprit.
"The teams deserved a referee in top form but that was certainly not the case with Webb.
"Spain's winning goal was understandably celebrated passionately by the Spaniards but the blunder by Webb which came before - he missed an obvious corner for Holland, took the shine off it, at least for the Dutch."
De Telegraaf noted: "The referee failed to calm the mood in 120 minutes.
"That he was booed at the final ceremony by both the Dutch and Spanish fans was significant."
De Telegraaf was disappointed with a final which was a niggly, fractious affair.
It said: "The tone was often unpleasant.
"Nasty with violations that had nothing to do with football.
"Too few goals, too much tension.
"It was not helped by referee Webb.
"But from a technical point of view the game ended with the right team as world champions."
De Telegraaf columnist Jaap de Groot also finished by praising Spain.
"In 1974 (when Holland lost to West Germany in the final) we were the best team," they said.
"In 1978 (when they lost to Argentina) we were the better team.
"In 2010 we were just not good enough."
FIFA boss Blatter backs under-fire referee Webb
FIFA president Sepp Blatter today said English referee Howard Webb had a "very hard task" in Sunday night's bad-tempered World Cup final between Spain and Holland that saw a record 14 yellow cards shown.
Kuyt joins in criticism of World Cup final referee Webb
Holland striker Dirk Kuyt pointed the finger of blame for his country's World Cup final defeat by Spain at English referee Howard Webb.
Stranded dog rescued with sausage dangled from drone
Latest World Cup
Roberto Martinez against plans to hold World Cup every two years
Gianni Infantino thinks there is already majority support for biennial World Cup
Gareth Southgate keen to learn all he can about Qatar human rights issues
Taking a look at the qualification picture for next year's World Cup
The key questions answered as the Qatar World Cup line-up begins to take shape


Just 45 minutes from Cancun's International Airport, Playa del Carmen began as a small fishing village and has grown into a cosmopolitan city where people from around the globe have relocated permanently and made this city their home.
Playa del Carmen real estate offers something for everyone – for those who love the hustle and bustle of the city, condos in downtown Playa del Carmen put you within walking distance of everything, internationally known restaurants, shopping and more. If peace and quiet is what you are looking for, beautiful gated communities like Playacar, Selvamar and El Cielo offer houses for sale in Playa del Carmen which put you just minutes away from downtown and the beach.
A city that has seen its tourism grown year after year, Playa del Carmen offers many amazing opportunities to invest in Caribbean real estate.


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LuxArtAsia
Art Stage opening draws international collectors
The opening of Art Stage Singapore drew international collectors from Asia and the West, thought artists appeared to be a bit thin on the ground. Julian Isaac and Wim Delvoye walked the floor, while Manit Sriwanichpoom and Natee Utarit could be found at the booth of the galleries representing them. Bernar Venet and one of the Gao Brothers (the other one had to stay in NY) were doing the round of interviews as journalists latched onto well-known names.
First impressions: the fair is better laid out than last year; there are large installations peppered throughout (as opposed the large Ai Weiwei tucked at the back of the fair last year); galleries are adopting a less is more attitude with few works on the walls, but those tend to be on the really big side; fewer Chinese artists than usual; quite a lot of sounds installations; very little pop art (when Murakami was dominating last year)..... overall a lot of fresh new works. Early sales were reportedly slow though, but this may have a lot to do with the fact that galleries are often showing a new generation of artists...not a bad thing actually...
Do Ho Suh @ Lehmann Maupin
Can Lorenzo Rudolf rescue sourtheast Asian artists to be overshadow by Chinese ones? Yes he can!
Thai artist Navin Rawanchaikul has the most witty take on the Asian art scene spread across a 9-panel wide painting that presents the who's who in Asian art from artists to collectors and curators.. It greets visitors as they enter the fair; along with a huge ash painting by Zhang Huan (stunning!).
Here are some early snaps... more to come.
Masriardi
Agus Suwage + Masriardi
Asian Art Chinese art Indonesia Art Singapore Thai Art
From Italy with Love: A Look at the Collecting Path of the Maramotti Family
At 27, Hungarian artist Mona Osman is still at the early stage of her career and while the Royal College of Art student has had a solo exhibition at an artist-led contemporary gallery in London and was part of group show at Saatchi Gallery last year, perhaps her biggest break will come later this year: The young painter will have a solo exhibition at the Collezione Maramotti, one of Italy's top private art museums, which presents the ever-growing art collection of the family that founded the upmarket ready-to-wear company Max Mara.
"To have this opportunity is a huge honour and an amazing chance to expand and visually showcase my research," Osman says, adding her challenging project will compared the Bible to notions of existential philosophy.
Over recent years, the museum has increasingly been supporting young artists and each year gives three or four emerging or mid-career artists carte blanche to create works that will later form part of the museum's collection.
"We believe that …
Interview: Erwin Wurm on his Humanoid Sculptures
Erwin Wurm likes to distort forms. Over the years, he has slimmed down houses, fattened up cars, and used his own body to redesign the shape of furniture. "A lot of my work is about destroying one thing to create another," the Austrian artist says of his process. One of his latest series, Stone, continues this exploration by setting small rocks on a pair of legs, giving a twist to the expression "carrying the weight of the world on your shoulders". The small humanoid sculptures recall the Hypnosis series Wurm created in 2008, when Wurm used potato-like shapes to form the torso and head of a body in a highly polished aluminium finish on top of legs, in a contrasting matte finish. In the Stone series, the shiny aluminium potato shape has been replaced by a rock covered in greenish moss. Each work has a distinct and expressive personality due to the treatment of the white acrylic resin legs (variously posed, either standing, running, barefoot, or dressed).
Inspired by German philosophers…
Singapore Art Scene 2.0: Can new art fairs help establish Singapore as a commercial art hub?
In January, the Singapore art scene received a shock to the system. Eight days before it was due to start, Art Stage Singapore, the city state's premier annual art fair and the anchor event of Singapore Art Week, was abruptly cancelled. Citing the "very difficult market situation in Singapore as well as unequal competition," Art Stage's President Lorenzo Rudolf pulled the plug, noting that while the fair had brought over 500 galleries to Singapore over the previous eight years, relatively few returned due to the lack of local sales.
An archetypal Singapore can-do spirit immediately swung into motion including a Facebook page set up by Plural Art Mag that helped galleries find alternative exhibition spaces while non-profit entity Art Outreach, with the support of various government agencies and the Marina Bay Sands (MBS), set up a pop-up event — at the MBS's exhibition space now abandoned by the fair — which brought together 14 galleries that had intended to show at Art Stage.
Art mark…
@LUXARTASIA


This is a Mass Effect Andromeda character customization guide. Here you will discover the many choices you may select when creating your own version of Scott and Sara Ryder.
You can choose from two genders: male and female. The male default face is Scott's, while the female default face is Sara's. If you chose one, your twin will be the other.
This is where you choose the default appearance for Ryder or select a custom appearance to customize your look.
There are six training selections to choose from: Security, Biotic, Technician, Leader, Scrapper, and Operative.
This is where you customize the name of your main character. Note: just like in the first three Mass Effects, Ryder will always be named Ryder.
This is where you choose the default appearance of your twin or customize their look.
This is where you choose the gender of the legendary Commander Shepherd, first human Spectre and the Hero of the Citadel.


A Guide To Natural Sleep Remedies. You Could Be Causing Your Own Insomnia Without Even Knowing it! ======================= After reading this book you will have the information you need to turn your sleepless nights into restful ones, waking in the morning refreshed and alert rather than tired and anxious.


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หน้าแรก » off the pitch
JDT ACE ON THE MOVE! | OFF THE PITCH
luka 07 Oct 2020
Eriksen & Sergio Ramos Could Leave In January! | OFF THE PITCH
Buaksib Asia presents Off The Pitch. What happened in the football world? What is the latest news from the football scene? We got you covered with the latest football news from all around the world. Ramos open to offers, Inter Milan's flop ready to move, Beckham's team could change their name, and Spurs Aces fined
Diego Costa On The Move & Zlatan Making Headline Again? | OFF THE PITCH
It's a new episode of "Off the pitch". Dana is back with a new episode and she will review the latest trends, rumors and news in the football world. Diego Costa's contract was terminated Costa just finished his second spell in Madrid. It's time for the striker to move on and look for a new
Unhappy Mo Salah & Neymar Linked To A New Hottie? | OFF THE PITCH
Dana is back with another episode of the "Off the pitch". She will review the latest rumors and news in the football world. Is Neymar connected with a new girl? PSG's forward is linked with a new girl. Neymar is constantly liking the posts of the model Melodie Penalver. Melodie is a very popular model,
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Aubameyang Flop Because Of Arteta? | OFF THE PITCH
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Ole's Time Crisis | OFF THE PITCH
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OFF THE PITCH: World cup winner to JDT? Italian job for Eriksen
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OFF THE PITCH: Chicharito Cried Over Transfer To LA?, The Red Devils Chasing England Boss.
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VAR should have done better | OFF THE PITCH
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OFF THE PITCH | Football Player Got Arrested For Murder?
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John Chamberlain (1927-2011)
The Secret Life of Hernando Cortez (excerpt) (1968)
John Chamberlain was born in 1927 in Rochester, Indiana. He grew up in Chicago and, after serving in the navy from 1943 to 1946, attended the Art Institute of Chicago from 1950 to 1952. At that time, he began making welded steel sculptures influenced by the work of David Smith. In 1955 and 1956, Chamberlain studied and taught sculpture at Black Mountain College, near Asheville, North Carolina, where most of his friends were poets, including Robert Creeley, Robert Duncan, and Charles Olson. By 1958, he began to incorporate scrap metal from cars in his work, and from 1959 on he concentrated on sculpture built entirely of crushed automobile parts welded together. Chamberlain's first major solo show was presented at the Martha Jackson Gallery, New York, in 1960.
Chamberlain's work achieved critical acclaim in the early 1960s, gaining him a reputation as a three-dimensional Abstract Expressionist. His sculpture was included in The Art of Assemblage at the Museum of Modern Art, New York, in 1961, the same year he participated in the São Paulo Biennial. From 1962, Chamberlain showed frequently at the Leo Castelli Gallery, New York, and in 1964 his work was exhibited at the Venice Biennale. While he continued to make sculpture from auto parts, Chamberlain also experimented with other materials. From 1963 to 1965, he made geometric paintings with sprayed automobile paint. In 1966, the same year he received the first of two fellowships from the John Simon Guggenheim Memorial Foundation, he began a series of sculptures with urethane foam, which he rolled, folded, cut, and tied. He then applied methods of crushing and compression to galvanized steel and paper bags. These were followed in 1970 by sculptures of heat-crumpled Plexiglas. During this period he also made the film The Secret Life of Hernando Cortez (1968), starring Andy Warhol's superstars Taylor Mead and Ultra Violet. Chamberlain's work was presented in a retrospective at the Guggenheim Museum, New York, in 1971. Small examples of his newest engagement with aluminum foil were exhibited for the first time.
In 1972, Chamberlain began once more to make large works from automobile parts. Until the mid-1970s, the artist assembled these auto sculptures on the ranch of collector Stanley Marsh in Amarillo, Texas. From 1977 on, Chamberlain pursued photography with a panoramic Widelux camera. His next major retrospective was held at the Museum of Contemporary Art, Los Angeles, in 1986, accompanied by the publication of John Chamberlain: A Catalogue Raisonné of the Sculpture 1954–1985. Chamberlain has received numerous honors for his artistic achievements, including the Skowhegan Medal for Sculpture and the Lifetime Achievement Award in Contemporary Sculpture from the International Sculpture Center, Washington, D.C. (both 1993); Gold Medal from the National Arts Club, New York (1997); and Distinction in Sculpture from the Sculpture Center, New York (1999). In the last decade of his life, the artist expanded his oeuvre by undertaking a new medium: large-format photographs printed on canvas, altered with digital visual effects, cut into regular vertical segments, and collaged to create new compositions. In 2007, he began to create a new body of work recasting his miniature foil sculptures from the mid-1980s in monumental scale. He also acquired a cache of vintage automobiles, from which he culled the materials for his last sculptures—confident and majestic in their imposing dimensions, displaying the maturation of his earliest sculptural explorations of abstraction, stance, and fit. Chamberlain died on December 21, 2011, in New York;


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Required level of English language proficiency: B2 level (IELTS min. 5.5. or TOEFL IBT minimum 72 or equivalent)
Duration: 2 semesters - The first semester starts in October and finishes in January, while the second semester starts in January and finishes in May.
Over 85% admission rate to Hungarian Medical Universities
The Foundation Year for Medical Studies Program has been designed for students who would like to continue their studies at one of the medical universities in Hungary, and who, therefore, first need to and wish to extend and deepen their knowledge in the subjects required at the entrance examinations of those universities. In addition, the program also prepares future students of dentistry, pharmacy, physiotherapy and veterinary medicine for their university entrance examinations.
WBS reserves the right to test its students English language knowledge upon arrival in Hungary and prior to the commencement of the foundation programs.
For more detailed information, please contact us at info@wbsc-h.eu, or if applicable, turn to WBS's Exclusive Representative for Iran: Mohammad Reza Mahrough
Phone: +36 3030 52859;
E-mail: reza1366@me.com
Introduction to Biochemistry
Basic Physics
Linguistic Knowledge and Skills
English for Professional Communication
Please, note that each course will demand a considerable amount of out-of-class preparation and self-directed learning. Regular attendance, active participation, completion of in-class and out-of-class assignments are also required. Final grades will be based on continuous assessment and end-term examination results.
NB: The topics of the above subjects will cover the requirements of the entrance examinations of Hungarian medical universities, and mock-exams based on previous entrance exam questions will be organised. Students must note that the chances of their acceptance to the university will depend on their diligence and academic performance.


It has been described as 'the Sistine Chapel of the UK', and now is your chance to get a close-up inspection of a little-known British masterpiece. The Painted Hall at the Old Royal Naval College Greenwich is the subject of major restoration and regeneration works, including the creation of a new visitor centre, Sackler Gallery and café. While restoration work to the Hall's incredible ceiling is going on you have a once-in-a-lifetime opportunity to get almost as close to the work as the artist who painted it.
Founded in 1694, the Old Royal Naval College in Greenwich was designed by Sir Christopher Wren, with the walls and ceilings painted by Sir James Thornhill between 1707 and 1726. The baroque scheme contains scenes depicting the might of the British navy in the early 18th century, illuminated by over 200 scenes featuring historical and mythological figures. The work was a sensation, turning Thornhill into an art superstar, leading to his commission to paint the dome of Sir Christopher Wren's newly-completed St Paul's Cathedral, and eventually the accolade of being the first British painter honoured with a knighthood.
For the duration of the restoration work, which will clean the paintings as well as performing environmental interventions to preserve the art in its present state for at least the next century too, visitors will have a chance to view the paintings from a 60-foot high observation deck. From here you can watch the conservators at work and learn more about the building from experienced guides.
Daily tours of the Painted Hall ceiling run from 10am – 5pm at the Old Royal Naval College Greenwich. Get more information and book a tour here.


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Amanda Sergeant is a British newsreader. Before breaking into the world of journalism, she was a part of Radio City 1386AM, a Swansea based hospital radio station.

Sergeant began her career starting as a BBC radio researcher in 1993, after completing her postgraduate training at the Centre for Journalism Studies at Cardiff University.

She progressed quickly through the ranks, becoming a TV reporter specialising in live outside broadcasts, then a senior TV presenter with BBC Wales.

Since joining GMTV, Sergeant has reported on a wide variety of national and international news stories, from the Kosovo War in Macedonia to New York Fashion Week and the Grammys in Los Angeles.

She divides her time between London and Wales where she lives with her husband, broadcaster and writer Miles Fletcher.

She is also an accomplished gardener.

Sergeant joined national breakfast station GMTV in 2004, where she was a news correspondent and occasional relief news presenter; however, she left in early 2008.

External links
 Amanda Sergeant at gm.tv

GMTV presenters and reporters
Alumni of Cardiff University
Living people
Year of birth missing (living people)


27TBFC/G is a High Definition metal dome tweeter with a wide, soft polymer surround and a rear chamber.
Voice coil windings immersed in magnetic fluid increase short term power handling capacity and reduce the compression at high power levels.
Precision moulded chassis from glass fibre reinforced plastic, and its front design offers optimum radiation conditions.


If you're looking for something bold to help you reinvent a room this year, try thinking beyond your basic solutions with paint. For 2011, wallpaper is where it's at — and not just for accent walls, either.
Seems like we were ahead of the curve on this one a little bit. While we've yet to actually order paintable wallpaper, we have managed to get our hands on a couple of samples and LOVE the look. The idea of customizing the colorways to suit your individual tastes is quite the seller for this wallpaper, as well as the ability to change your mind with just a coat of primer and a gallon of paint instead of having to tear the whole thing down.
If you're looking for a more subtle vibe, tone-on-tone papers can be the way to go for you. They can make a dramatic statement with color, yet leave a lasting impression once the subdued pattern is revealed upon further inspection. They're also great for added elegance in small spaces such as entryways and guest bathrooms where a larger, louder pattern might overwhelm the space.
Nothing is more dramatic and attention-grabbing than metallic ANYTHING, but this is especially true of wallpaper. From soft golds to rich bronzes and sharp silvers, a metallic wallpaper is a fabulous way to create instant glamor and decadence in a space. If you're looking for a way to add some definite oomph to a room, metallic wallpaper just can't be beat.
Looking for the ultimate in decadent wallpaper? How about trying on some hand-painted and hand-screenprinted papers for fun? These beauties appear more as fine works of art carefully created upon your walls than your average big-box off-the-shelf paper. Many wallpaper companies including Graham & Brown, Hygge & West, and Flavor Paper carry hand-painted or hand-screenprinted in their collections. If you're looking for a statement room, hand-created is the way to go.
Maybe you've already taken the jump with some wallpaper and really want to make it pop. Consider adding matching textiles to the space. Reupholstering a chair, adding drapes, or even coordinating the carpet in the same pattern and colorway as the walls will not only make a room feel incredibly pulled together, but it will help create the illusion of more space since everything will blend into one another. Make sure, however, that you go with a more traditional or neutral paper/fabric that you won't mind looking at for years to come if you go this route — you don't want your room to scream 2011 in 2020.
Want more wallpaper suggestions? Check out our post on wild wallpaper choices, where you'll be able to find three of the trends (paintable, tone-on-tone, and metallics) just waiting for your perusal. And if in the end, you decide wallpaper's just not your thing, take heart — here's our easy wallpaper removal tips.


How do newly synthesized proteins find their correct destinations within a cell, and how are they able to pass across the tightly sealed intracellular membranes? These were the central questions that Günter Blobel began to address in the late 1960s. He started by analyzing how newly synthesized secretory proteins are first targeted to and then translocated across the membrane of the endoplasmic reticulum (ER). These two steps are prerequisites for secretion of proteins out of the cell.
Present view of protein translocation across the ER membrane. The signal peptide, emerging from the ribosome, binds to the signal-recognition particle (SRP). The SRP-ribosome complex then docks to the SRP-receptor and channel ("translocon").
SRP dissociates from the receptor and the nascent polypeptide chain is translocated through the channel into the ER lumen. The signal peptide is finally cleaved and the protein is secreted out of the cell.
the protein translocating channel (the "translocon").


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How technology is accelerating construction at Gaudí's Sagrada Familia
A recent trip to Barcelona afforded a visit to Antoni Gaudí's stunning architectural venture the Sagrada Familia. Construction began in 1882, with work on the impressive Catholic church due to continue until at least 2026. Today the site, which was listed as a world heritage destination in 2005, welcomes over 3.5 million international visitors every year and is among the top ten most visited monuments in the world.
Behind this enormous construction and tourism operation lies an impressive portfolio of complex IT projects tailored to the church's unique requirements. The Stack had the opportunity to speak with Fernando Villa, CIO at the Sagrada Familia who has headed up its tech department since 2013, and has helped transform it from a low value, infrastructure-orientated team to a strategic business unit.
On the importance of standardising growth, while reducing costs across his projects, with a particular focus on technological advances, networking, operations, and training, Villa outlined a number of innovative proposals which the team is looking into adopting and exploring over the coming years.
Testing innovative technologies
One of these schemes, in collaboration with the University of Barcelona, includes a drone project which would see UAVs gather facial scans of visitors for security purposes, as well as collecting information to be used for conservation and maintenance of the church spires.
Villa is also introducing a virtual reality (VR) pilot programme as an architectural design aid. "The new tool allows our team of architects to make decisions very quickly," said Villa. "Virtual reality enables us to see the designs scaled to their actual size, with the textures and materials required whilst allowing us to make changes with minimal impact on cost and time. This saves us time and money without constructing mock-ups."
Villa explained that his department was currently industrialising the process with site architects using 3D tools inside the VR platform – "Once the modelling process is complete it only takes minutes to process and upload the model to virtual reality."
All this data will be processed to obtain information that will allow us to make decisions for the new constructions and enable maintenance of the existing structures.
Incorporating several glasses simultaneously is also an interesting possibility for Villa, who suggested working with a variety of VR technologies in the future.
Augmented reality (AR) is also being considered as a further support tool in the maintenance and conservation of the church. Villa explained that a current AR pilot project is looking at conducting a detailed scan of the 'Nativity' façade to attach geolocation tags. With this information, Villa expects to work with tablets and VR glasses to support maintenance work, and obtain the required area information in real-time while digitally tracking it.
"This system will allow us to identify and understand the origin of a stone, its placement year, composition and physical characteristics. It will also enable an analysis of the evolution of an area through images. We can identify electrical installations and networks that exist in a specific area without opening the wall," he said.
While not outlined in current plans, the CIO noted that after this first phase, augmented reality could also be used in the future to place designs in the real world.
Villa further pointed to Big Data as a potential area for development in 2016. "We are currently installing sensors throughout the church to support maintenance. These include environmental sensors, structural sensors and geotechnical sensors. All this data will be processed to obtain information that will allow us to make decisions for the new constructions and enable maintenance of the existing structures."
He continued that this complex network of systems will generate such large volumes of information that work needs to be done to increase processing capabilities and storage efficiency.
Finding a consistent, reliable support solution
This challenge, Villa explained, has been alleviated over recent years with the installation of an on-site micro data centre.
"High-density racks have secured our requirements for the next 4-5 years. Scalability was one of our original specifications for the micro data centre – it had to provide space, power and cooling capacity to support the growing use of IT. Cloud options were considered but dismissed because of potential latency problems."
The solution is supported by a spring-loaded base to isolate it from vibrations created by the construction machinery and the nearby traffic.
For Villa, a micro data centre was the answer, providing the project with a containerised, portable solution. Relocation was also a key consideration because of the centre's location on a working construction site.
"Schneider Electric became our strategic partner and helped to advise and deliver a solution that would tackle some specific areas for us; infrastructure, communications and security. They combined two 25 foot prefabricated modules to create a single data centre, which would provide the optimum space to support our immediate requirement while allowing us to expand or scale up," Villa explained.
Today, the micro data centre houses 10 IT racks with power distribution units (PDUs). It is scalable to 90kW capacity, includes cooling infrastructure and is backed up by a Symmetra PX uninterruptible power supply (UPS) and a 500kVA generator. Villa suggested that this reliability provides extra peace of mind, with a minimum of 99.999% availability.
Specific to the Sagrada Familia, the data centre also required essential customisation. "Firstly, the solution is ruggedised, supported by a spring-loaded base to isolate it from vibrations or potential shocks created by the construction machinery and the traffic passing just a few feet away.
"Secondly there is a dust trap between the door to the container and the internal entrance to the infrastructure, which helps to protect the IT equipment."
The new facility has underpinned the growth potential and allowed Villa's advanced IT projects to scale. He now looks forward to adding future services, boosting business outcomes and supporting the completion of Gaudí's dream.
AI Augmented Reality Data Centre IoT VR


When we lose weight we tend to lose fat from over our whole bodies. Keep reading to learn more about why jowls develop, how you can reduce your chances of developing them, and what you can do to minimize their appearance. If you see more definition in your jawline and the lines below your nose begin to disappear, lose weight two days easily treatment could work for you.
Try to keep your head at a natural, comfortable angle when using a computer or phone to keep your neck skin from getting bunched up or stretched out. The chemicals in cigarettes and other forms of tobacco can damage your skin. Jowls are the areas of the face under the jaw line that give the face a heavier or saggy appearance.
For some people the difference will be dramatic, for others less so, but all should enjoy some improvement in facial appearance. Limit your screen time.
Learn about costs, side effects, recovery time and possible complications. Go for apples, oranges, all sorts of berries and grapefruit because they are low GI carbs and they packed full with anti-oxidants. Limit your exposure to the sun.
If you need to add salt on your recipe, do it with a salt shaker or sprinkle it with your hand instead of a spoon.
Ways to help you lose face fat and a double chin as well as look fit with glowing healthy facial features. Drink more than that if you are an active person and always exposed to the sun. Yes you can diet plan ratings way you'll avoid disappointment.
To prevent jowls Avoid smoking. What Causes Sagging Jowls?
Choose your fruits carefully though; control the amount of bananas, grapes top rated diet pill pineapples because they are high in fructose. Chin implants can make a dramatic difference.
Using a computer or how to burn leg fat down at a smartphone for long periods of time can make the skin around your remove jowl fat lose its lose weight kissing over time. Remember, that fold formed because the skin lost volume and slid down.
The older we get, the more fat we lose in our faces.
What do you look at first when you meet somebody? The two lines you noticed below your nose are the nasolabial folds, which become more pronounced with age. As can you actually lose weight by rubbing your stomach age, the skin starts to loosen.
Sodas and sugared drink do not help because they contain sugar and will lead to bloating and other health issues. How to Get Rid of Jowls Now we know how to get rid of jowls without ever going under the knife. Most importantly, gain a realistic understanding of what the procedure can and cannot do for your appearance.
Focus on eating can you actually lose weight by rubbing your stomach and a less calorific diet, and once you start to lose overall body weight you will see begin to see you are losing facial fat. The excess fat removed during jowl liposuction can then be recycled to fill in laugh lines or add natural-looking definition to the chin and cheeks.
Another method that sounds strange but has been said to work for firming up a double chin: While Kythera said these side effects were 'temporary' and mild-to-moderate in severity, in previous fat burn app 13 per cent of how to burn leg fat dropped out of the trial due how to lose weight on third shift these side effects.
James Roland About the Author: You can also protect your muscles by taking a minute break for every hour of computer work that you do. This is something that you can do for a few minutes everyday, and it can eventually see some difference in your top rated diet pill.
Nicotine and other chemicals in cigarettes can damage collagen and elastin. Speak to people who've had the same procedure. Eat well, drop the sodium and saturated fatty meals. Once this happens, gravity causes it to sag and descend to the area on either side of your mouth and chin.
Stick to plain water. Getting a sun tan also makes you look leaner and helps get rid of lots of water retention.
Folded neck skin can be smoothed, so you can achieve noticeable, beautiful, and natural-looking facial rejuvenation. If sagging jowls were a muscle problem, exercises would help. ATX is made from a purified synthetic version of deoxycholic acid, a naturally occurring molecule in the body.
Puffy cheeks and face fat can be the effect from water retention. You look at their face first right?
Plus, they are filled with fiber that gives many health benefits. Many people who want to lose face fat have a double chin. What if I already have jowls? Genetics Your genetics can also determine how to burn leg fat or not you remove jowl fat jowls and how noticeable they become over time. However, if you lose weight through dietary and exercise changes, the face is among the first areas to show that weight remove jowl fat.
Can you lose weight on 5mg of prednisone with ATX contours the area under the chin by destroying fat cells, while leaving surrounding tissue largely unaffected, is it harder to lose weight after age 40 manufacturers Kythera claim. Another option is a small surgical tuck up, or mini-lift, jaw-lift, neck-lift, micro-lift to remove jowl fat up the jowls.
In some cases, you may want to do a full facelift. Nonsurgical procedures, such as top rated diet pill, lasers, remove jowl fat peels, can change the composition of the collagen in your skin.
James Roland James Roland started writing professionally in Get your doctor's opinion, advice and perhaps a referral. Drink Water - Lots of it: This way you can control the amount of salt on your food. When it comes to a sagging jawline, the best way to tighten neck skin is to restore the volume that has been lost.
The procedure skyrocketed in both women and men, as well as in all patients over the age of 20, with the largest increase seen in patients age 40 or older, it said. If you naturally have thin remove jowl fat or limited amounts of remove jowl fat and elastin in your skin, you may start to notice jowls early in life.