text:
Fable 4: Right These Wrongs & Revitalize the Franchise
For all it does right, the Fable series still does a lot wrong, and there are some revamps needed for Fable IV to succeed!
Well, the cat's pretty well out of the bag at this point. What was first a rumor started by an offhand tweet is now gaining traction and being reported as legitimate news -- Fable 4 is coming!
An official announcement is expected soon that Playground Games -- the developer behind the Forza Horizon series -- is now taking up the Fable franchise after Microsoft shuttered Lionhead Studios back in 2016.
This is huge news for fans of the franchise, who were either bummed by the cancellation of asymmetric, free-to-play entry Fable Legends or just simply felt that was the wrong direction to take the franchise in the first place.
While we've had the Fable Fortune CCG to keep us occupied with a fun (if overly familiar) card game experience, frankly, it hasn't gained a large enough base to be worthwhile for many players, and the game definitely failed to fully capitalize on the major elements of the Fable universe.
Although not everyone agrees, personally I can't wait for a Fable IV release date to be revealed, so long as we see some changes to the formula that don't stray too far from what makes Fable unique.
Ready to don your chicken outfit once more?
Time For Updates ... Within Reason
There's always a gamble when a long-running series changes hands, and right now, much of Fable 4 is a gigantic question mark.
Take Microsoft's other big series, for example. Gears Of War 4 changed studios and came out mostly great, keeping intact those things that people loved (horde mode, chainsaw duels, cover system) while adding in some new and innovative systems.
There were elements that longtime fans didn't love, but overall it was a solid entry in a strong franchise. The same can't be said for disasters like Dungeon Siege 3 or The Bureau: XCOM Declassified, however, where those franchises saw baffling changes in style that left fans scratching their heads (or flipping up their middle fingers).
Hopefully we don't see as radical a departure as with those botched series, but at the same time, we need a Fable overhaul. Now I'm going to admit something here that may put me in the minority, but ... I actually loved Fable III.
It was an extremely fun game with hours of hilarious entertainment. I couldn't get enough of tracking down evil lawn gnomes who berated me mercilessly, running a kingdom while wearing a purple chicken outfit, discovering the wonderfully bumbling Sam and Max during their misadventures mucking about with the Normanomicon, and so on.
That being said, there were flaws, and some big ones, that really need to be rectified during the development of Fable 4.
Pro-tip: don't cast spells that bring inanimate objects to life.
This is probably the first and biggest gripe any longtime fans of the series will bring up. Making the pause / menu / equipment screen into a separate area called the Sanctuary didn't make a lot of sense when a standard menu screen would have been a better option.
Having to go through a loading screen to enter the Sanctuary and then another loading screen to enter the armory to pick a different sword was just bad design, plain and simple.
The world map in the Sanctuary was also such a hit-or-miss affair. Sometimes using the magnifying glass for fast travel would plop you right outside the area you wanted to go ... and sometimes it would throw you at the far edge of the map so you had to trudge through yet another round of wolves and skeletons to get to your destination.
This got particularly frustrating when doing dozens of the exact same friendship missions to fetch or deliver something for every single NPC you wanted to like you. While we don't necessarily need to be led by the hand with the glowing trail, we also need a smoother way to navigate the world of Albion in Fable IV.
Welcome to the worst menu screen ever
Don't Oversimplify Albion
Fable III went out of its way to simplify many of the elements from the previous games to cram more in, and that frequently backfired. The Road To Rule system was significantly too dumbed down, and frankly, not a good way to express RPG leveling.
Character development isn't the only area that could benefit from a bit of a spruce up, however. We really need to see more life given to the denizens of Albion. Fable's NPC interactions are the heart of the game, and Fable 4 needs to better distinguish the various villagers.
Romancing Carla the tavern wench should be a different experience than romancing than Phil the blacksmith, rather than just a copy/paste scenario where you choose slightly different expressions.
On that note, an expansion on the the expression system is in order, which was simplified and toned down for Fable III. Pulling out most of the game menus and only giving extremely pared down options on which expression to use in a conversation felt like a big step backwards.
Albion as a whole could benefit from a scaling up by an order of magnitude into something more open -- think GTA, Skyrim, or Breath Of The Wild in scope -- which could really put Fable over the top and into the hallowed halls of gaming history.
In an open world, that annoying dog who only digs up paltry amounts of gold could become a faithful mount companion that plays a much bigger role.
Who's a good boy? Honestly, not really you.
Story And Pacing Tweaks
Gaining allies and building up an army to topple a kingdom are standard fantasy fare that can be crafted into an epic and unforgettable story if presented in the right way.
Sadly, the second "half" of Fable III (which was really more like a quarter) plummeted off a cliff and went by far too fast. The ending was also fairly anti-climactic, as the final shadow invasion really didn't feel that dangerous and could have been significantly more epic.
The whole Fable experience could really be extended out with a bigger focus on post-story content to keep building up (or destroying) your empire and exploring the game world. Buying a mansion, having a family, and starting a real estate empire feels like it should be the start of an epic journey, and not the conclusion.
Fable Decisions and Consequences
What happened to the the transformation the main character undergoes when choosing good or evil options, and why doesn't it ever actually match what you see on the box art for the game? Fable III was sorely lacking on that front.
The series as a whole is supposed to be all about choice, so Fable 4 developer Playground Games needs to give us more. While it was fun (if perhaps totally out of place in the context of the story) to suddenly become significantly more evil and callous than the evil king you'd just deposed, the extremely binary good/bad choices at the end of the previous game really felt like they needed more nuance.
Why weren't there any middle-of-the-road options, and why couldn't you choose to do other things completely to solve those problems? Likewise, the game needs to display more reaction and consequences to the actions you take.
Deciding between an orphanage or a brothel doesn't have much in-game effect
Improving And Expanding The "Fable-isms"
There are reasons people were excited about the first game, and promises of those same elements kept them coming back, from physically changing to match your alignment to the ability to buy real estate and marry anyone you want.
These options need to be brought back full force, and improved and expanded on. While Fable is one of the few games that lets you be a deadbeat mom or actually be there for your kids, it feels like the marriage and parenting systems need to be expanded in some meaningful ways that are less of an afterthought.
Likewise, the game's core mechanic of choosing between melee, ranged, or spell combat needs an overhaul. Shooting with a rifle was just objectively more powerful in Fable III than swordplay or waiting for a spell to power up. Combat as a whole has felt frequently too easy. Don't get me wrong, I don't want to see Fable go the route of Dark Souls, but the combat could use some major tweaking.
Fable 4 Release Date
While we don't know the release date yet, there are plenty of reasons to be excited for the impending Fable IV announcement.
Playground Games is reportedly bringing on a very large team to tackle this "unnamed" RPG project, and while the developer's previous titles may not seem to lend themselves to the Fable style, having an established team with ample resources at hand suggests we might finally get something worthy of the series name.
The question is just what type of game should we expect? We know from developer interviews that Lionhead wanted to create a darker Fable 4, but was instead tasked with the games-as-a-service model with Fable Legends. While the humor has felt part and parcel to the series for a while now, I wouldn't mind seeing a grittier, more steampunk-y Albion more along the lines of Dishonored -- but if Playground goes full throttle into the humor instead, I can't say that would be a bad thing.
What do you think Fable 4 needs to do to succeed, and when do you think we'll finally get our hands on this long-sought game?
...and we're willing to wait a long time so long as the end product is worth it!
Games Fable 2Fable 3Fable 4Fable FortuneFable Legends Genres ActionAdventureBoard, Card, and DiceRPGStrategy	Platforms Xbox One	Tags playground games
Published Jan. 18th 2018
Keep Your Memories: We Don't Need Fable 4
Microsoft Shutters Lionhead Studios
Microsoft Is Bringing Back Fable
Fable Fortune Class Tier List
Fable Fortune Deck Building Guide: Gravedigger
Fable Fortune Review: Albion Gets The CCG Treatment In A Very Familiar Way
Fable Fortune Shapeshifter Deck Building Guide
Fable Fortune Beginner's Strategy Guide
5 Best Animal Companions in Western RPGs
More Fable Legends Content
Fable Legends Game Page
Fable Legends Articles


SHAMPOO.IE - New product range alert, Nak Hair is here!
Treat the scalp with care for thicker, fuller hair!
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In this research the powders of TiO2, WO3 and graphite were mixed and after milling with WC balls, the reduction procedure was carried out separately under vacuum and nitrogen pressure. After blending the produced powder with Ni and the secondary carbides, (Ti0.93W0.07) C/C0.7N0.3-20 Ni based cermets were obtained through sintering at 1510 °C. To characterize the synthesized materials, XRD analyzer, SEM and EDS, STEM and hardness examiner were used. With the evaluation of core/rim included microstructures, it was observed that the addition of secondary carbide and also nitrogen in the reduction procedure, has a remarkable influence on the size of cermet microstructure. By the addition of nitrogen, the size of (Ti0.93W0.07) C microstructure was decreased about 3 µm. In this investigation it was shown that the increase of Mo2C from 2 to 8%, the amounts of tungsten and molybdenum elements were decreased in the core area. The weight percentages of W and Mo were changed from 20.01 to 19.5 and from 0.14 to 0.08, respectively. Also, in the rims, the weight percent of Mo, was significantly increased from 4.67 to 11.43. Furthermore, with the addition of just 2% Mo2C, the hardness of this composite material increased remarkably.
Keywords: Cermets, Secondary Carbides, Microstructure, Mechanical Properties.


text:
awatar – reprezentacja osoby w rzeczywistości wirtualnej
 Awatara – inkarnacja bóstwa w hinduizmie

Literatura
 "Awatar" – tytuł opowiadania francuskiego pisarza Théophile'a Gautiera
 Avathar – kraina ze stworzonej przez J.R.R. Tolkiena mitologii Śródziemia

Film
 Avatar – włoski dramatyczny film niemy z 1916 roku
 Awatar: Legenda Aanga – serial animowany
 "Awatar", czyli zamiana dusz – polski film z roku 1964 w reżyserii Janusza Majewskiego, adaptacja opowiadania Théophile'a Gautiera
 Avatar – film Jamesa Camerona z 2009 roku

Gra komputerowa
 James Cameron's Avatar: The Game – gra na podstawie filmu Avatar

Muzyka
 Avatar – szwedzki zespół muzyczny
 Awatar – album grupy Turbo
 Avatar: Music from the Motion Picture – ścieżka dźwiękowa do filmu Jamesa Camerona Avatar

redpajama_set_name: RedPajamaWikipedia


For those of you not familiar with Abby Larson's Style Me Pretty, you simply must check it out at http://www.stylemepretty.com. We were initially introduced to the site back in March when we received an invitation by Abby Larson to join their prestigious "Little Black Book" of VIP vendors. After seeing the site, we felt honored to be asked!
Being in the wedding industry, we receive emails from wedding sites on a regular basis inviting us to visit and join their site, many even offering a free link, and 95% of the time we are not impressed with what we see. Same ol' cookie cutter type weddings and half the time we don't recognize the names of the companies profiled. Then along came Style Me Pretty and it restored our faith, that yes, there are sites out there catering to brides with discriminating tastes, brides obsessed with style and color palettes and focuses on the details of the wedding. We always notice the details at weddings because that is what sets one wedding apart from another. After we place the cake, I always walk over and check out the tables, flowers, and any details that call my attention. I often get even more insight into who the couple is and what is important to them by looking at their details. We love that Style Me Pretty is a blogsite because this means that every day there is new information to absorb. I try and stop by as regularly as time will permit, and each time I get sucked in to Abby's beautiful color palette's and real wedding features. Rick is also a fan of the site and loves the aesthetic style and presentation and would probably visit it more regularly if he just had the time.
Whether you are planning a wedding or like us, already married :-) , Abby Larson's fabulous site will make you smile, and may just give you the urge to create!
Great site, I subscribed to the RSS feed for updates.


On this page you can see two screenshots of the WordCreator. The screenshots are available for the operating systems Windows 10, Windows 7 and Linux Ubuntu. You can switch the shown operating system with the links under the screenshots.
After you have started the application, first you will see the WordCreator on the tab "Creator". With this part of the program, you are able to create random words.
To create words, just click on the button "Create". In the upper left, you can define the number and length of the created words (in the screenshot 20 words with a minimum length of 3 and a maximum length of 6 elements), the used syllables can be defined in the box down left (see syllable list for more information about the structure and creation of custom lists). You can find more settings with clicking on "Settings". Screenshots and explanations of this can be found here.
On the second tab, you can find the counter. Using the counter, it is possible to create frequency profiles about the letters, syllables, words or character combinations of arbitrary texts.
First of all, copy the text, you would like to count, in the left box. After that, click on the button "Count" to show the result of the counting in the right box. Under "Settings", you can determine what should be counted (specific characters, exclusion criteria, characters, syllables, words etc) and how the results should be displayed. Screenshots and more explanations of the settings can be found here. If you right click the result, you can export the table for example as CSV, HTML, XLSX, ODS, DIF or as text file.
Further screenshots of the WordCreator can be found on the pages Counter and First Steps.
Screenshots of the old version of the WordCreator can be found here as well as on the pages Syllable Counter for Di- and Trigraphs, Unicode Counter, Help: TextCreator, Character Counter and Syllable Counter for real Syllables.


It appears a grave site has been damaged after what looks like car tires came through the cemetery.
"For him to say that's a bad shot, that's just kind of being a poor sport," Lillard said on his teammate CJ McCollum's podcast.
In the cremation section of one local cemetery, a new spot is reserved for the biggest teams in the state.
Our ancient human ancestors may have contributed to mega-herbivore extinctions: and we're repeating the pattern today.
It's called the Palmetto Lakeside Cremation Estates Garden, but it contains much more than sports pedestals.
Teacher group SC for Ed is encouraging teachers to reflect and take the day to rally for higher pay, smaller class sizes and other education reforms.
As NBCUniversal gears up to launch its own streaming services, Netflix may have to say goodbye to some of its most reliable titles.
Investigators say it happened at the Jones Physical Science Building and Hamilton College.
Vandals damaged graves and headstones in a Lexington Cemetery.
Do your kids need a way to beat the heat? Participating AMC Theatres have an answer.
"That smile is all the thanks we need," police said.
HFF represented the seller in the transaction, as well as in the sale of Borel Financial Center, the office component of the property, which closed in 2018.


Our client is a provider of 'cutting edge' transport infrastructure technology designed for transport management, monitoring and control. With the demands of the future being ever present their ingenious solutions will shape the Smart Motorways of tomorrow.
Reporting to the Head of Sales, you will contribute to the development and sustainable growth of the business in line with the sales strategy. The role will primarily focus on further penetrating, expanding, and protecting the companies nominated Key Accounts and will also involve developing other accounts within a UK geographical territory. Utilising demonstrable competencies of Key Account Management, the Account Director will focus on yielding both short and long term returns from each nominated account. You will also develop and manage nominated Key Accounts as well as develop acquisition strategies for target accounts. Secure order intake for the accounts and any leads/opportunities owned.
•Degree level education in a relevant discipline.
•Previous Key Account Management experience of customers with complex structures.
•Previous experience of Sales in a non-commodity technology/solution based market.
•Sales in a solution environment.
•Excellent written and oral communications.
•The ability to plan and strategise at a senior level.
•Keen attention to detail and budgetary constraints.
•Preparation and delivery of sales material such as presentations, industry papers and input to marketing documents.


I can't praise Bailey & Sons Roofing enough. They are so professional, every day the area was left clean and tidy. My new roof and velux window has transformed my kitchen/dining room. I have recommended Bailey & Sons roofing to friends. All I can say is if you want a roof repaired or replaced, these guys are definitely the ones to call. If I could give more stars I would.
Excellent company, excellent work. Would highly recommend.
We had these guy's check out the roof on our house. They did what needed to be done and charged us an extremely fair price. Fantastic service. I will not hesitate to recommend them to anyone who needs any roof work to be carried out. Top Guy's well pleased thank you.


This is a fantastic opportunity to develop a career as an Agricultural Consultant. This territory-based role provides a varied and challenging, exclusive opening to the consultancy sector. The successful, ambitious candidate will have an introduction to projects in the world of financial and farm planning, rural business grants, project management, basic payments, stewardship, livestock management, comprehensive budgeting and farm diversification.
Farming experience and a few years of agricultural employment following graduation with a degree or HND in relevant discipline.
Please call Hannah Graham on 01885 485527/01885 483440 or email your CV or enquiry to Hannah.graham@delacyexecutive.co.uk Thank you. De Lacy Executive will upload your CV to our database and retain some data about you in order to process your application. More information about our processing activities can be found at www.delacyexecutive.co.uk/privacypolicy. Please be assured that all contact is treated in complete confidence and your details will not be passed to a third party without your prior permission. Please note that this advertisement is not a job description and you should satisfy yourself about the full details at interview. De Lacy Executive is an Approved member of the Recruitment and Employment Confederation, which promotes high standards in recruitment practice, and is registered with the Information Commissioners Office. De Lacy Executive complies with all relevant data protection legislation.


text:
Mirage's Betrayal (thing)
See all of Mirage's Betrayal, no other writeups in this node.
(thing) by mblase Thu Sep 20 2001 at 17:03:23
Transformers: Robots in Disguise Episode Guide
Episode 9: Mirage's Betrayal
Original U.S. air date: September 18, 2001
Written by: Richard Epcar
A news broadcast about a large ruby which could be used in laser manufacturing catches the attention of T-AI and Optimus Prime, who see it as a likely target for the Predacons. The Spychangers are assigned to guard it, and at night the Predacons arrive to take it. Mirage is left on the roof to stop them because of his sharpshooting skill, but he skips the shot because the Predacons were too close to a chemical refinery, and they escape. Before they go, however, they leave a small bug on Mirage which they hope will lead them to the secret Autobot headquarters.
Instead, Mirage leaves the Spychangers in anger when he refuses to explain his failure to stop the Predacons. Hearing of his departure through the bug, Megatron allows Sky-Byte and the other Predacons to try and bring Mirage over to their side. When they meet him, Mirage says he wants to teach the other Spychangers a lesson and offers his help in leading them to a trap.
The Predacons show Mirage the new "mega-laser" they have built, which uses the ruby they stole. Mirage suggests he call the Autobots about the mega-laser and invite the Spychangers to meet him by it, setting up the trap. When they arrive, Mirage uses the Spychangers' secret hand signals to indicate the nearby Predacons and set up a surprise counterattack. He then destroys Sky-Byte's trigger for the mega-laser, and the other Spychangers work together to stop Megatron from using the second trigger. Mirage reveals that he knew about the bug all along, and his teammates' faith in him is restored.
Previous episode || Next episode
In the original Transformers cartoon episode "Traitor", the first Mirage was also accused of betraying the Autobots. (In that case, the cerebro-shells of the Insecticon Bombshell were responsible for his change of mind.) It's also interesting that Mirage and Ironhide are described as "old friends", since they are the only two Spychangers whose names come from original Autobots.
This is the only episode to feature any of the Spychangers developed as individual characters. At the same time, their unique emphasis on teamwork and military-like combat practice is highlighted to the point where it becomes the team's number-one weapon.
Skid-Z's Choice Secret Weapon: D-5 Spychangers to the Rescue traitor
Hope for the Future Transformers Robots In Disguise Transformers Episode Guide Mirage
Farm auctions rip me in half

redpajama_set_name: RedPajamaCommonCrawl


text:
Products Spectrin, alpha (Spectrin Non-erythroid alpha Chain, Alpha Fodrin, Alpha II Spectrin, FLJ44613, Spectrin alpha Non-erythrocytic 1, SPTAN1, SPTA2)
Spectrin, alpha (Spectrin Non-erythroid alpha Chain, Alpha Fodrin, Alpha II Spectrin, FLJ44613, Spectrin alpha Non-erythrocytic 1, SPTAN1, SPTA2)
Cat no: S5381-03E
The cytoplasmic cytoskeleton determines cell organization, shape and adhesion among other functions. Furthermore, the cell type-specific expression of intermediate filaments allows determination of the origin of many, otherwise unspecific tumors. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: frozen Optimal dilutions to be determined by the researcher. Hybridoma: Myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S5381-03E
Reactivities: Human, Rat, Chicken/Bird, Guinea Pig, Rabbit
Form: Supplied as a liquid in PBS, 1% BSA, 0.1 % sodium azide.
Purity: Ascites
References: 1. Sormunen R. et al. (1999) J. Pathol. 187, 416-423. 2. V
Additional info: Recognizes chicken a-spectrin at ~240kD. Reacts with the a-spectrin molecule of all mammalian nonerythroid cells. Species Crossreactivity: human, rat, rabbit, guinea pig.


text:
@interface LyphyInboxCell : UITableViewCell
@property (strong, nonatomic) IBOutlet UIImageView *imvBg;
@property (strong, nonatomic) IBOutlet UIImageView *imvAvatar;
@property (strong, nonatomic) IBOutlet UILabel *lblGroupName;
@property (strong, nonatomic) IBOutlet UILabel *lblShortHistory;
@property (strong, nonatomic) IBOutlet UIView *badgeView;
@property (strong, nonatomic) IBOutlet UILabel *lblMessageCount;

@end

redpajama_set_name: RedPajamaGithub


text:
Mutant Proteins (Protein, Mutant)
Subscribe to New Research on Mutant Proteins
Proteins produced from GENES that have acquired MUTATIONS.
Protein, Mutant; Mutant Protein; Proteins, Mutant
Networked: 809 relevant articles (18 outcomes, 49 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins
Proteins: 90489
Mutant Proteins: 809
Mutant Chimeric Proteins
1. Rubinsztein, David C: 8 articles (10/2015 - 04/2003)
2. Lyles, Douglas S: 8 articles (04/2014 - 12/2004)
3. Sakai, Norio: 7 articles (01/2014 - 08/2005)
4. Adachi, Naoko: 7 articles (01/2014 - 08/2005)
5. Seki, Takahiro: 7 articles (01/2014 - 08/2005)
6. Saito, Naoaki: 7 articles (01/2014 - 08/2005)
7. Borchelt, David R: 6 articles (05/2015 - 04/2007)
8. Sarkar, Sovan: 5 articles (10/2013 - 04/2006)
9. Zoghbi, Huda Y: 4 articles (03/2015 - 07/2009)
10. Orr, Harry T: 4 articles (03/2015 - 07/2009)
1. Neurodegenerative Diseases (Neurodegenerative Disease)
05/01/2012 - "Although currently there is no effective cure to prevent or slow down the progression of these neurodegenerative disorders, increasing the clearance of mutant proteins has been proposed as a potential therapeutic approach. "
01/01/2013 - "Emerging evidence indicates important protective roles being played by autophagy in neurodegenerative disorders through clearance of aggregate-prone or mutant proteins. "
01/01/2013 - "Therefore, findings in the current study provide detailed insights into the protective mechanism of a novel autophagy inducer, which is valuable for further investigation as a new candidate agent for modulating neurodegenerative disorders through the reduction of toxicity and clearance of mutant proteins in the cellular level."
04/01/2010 - "Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases."
04/09/2010 - "Chemical inducers of autophagy that enhance the clearance of mutant proteins in neurodegenerative diseases."
2. Neoplasms (Cancer)
05/01/2012 - "An improved quantitative mass spectrometry analysis of tumor specific mutant proteins at high sensitivity."
09/15/2013 - "Despite the prospect of treating AML and other cancers by targeting IDH mutant proteins, it remains unclear how these mutants affect tumor development and maintenance in vivo, and no cancer models exist to study the action of IDH2 mutants in vivo. "
01/01/2010 - "To better understand the role of p27 in tumor predisposition and to characterize the MENX animal model at the molecular level, a prerequisite for future preclinical studies, we set out to assess the functional properties of the MENX-associated p27 mutant protein (named p27fs177) in vitro and in vivo. "
03/12/1999 - "However, the study of mutant proteins identified in tumors that do not form tetramers has shown that they have lost the wild-type activity like most of the p53 DBD mutants. "
02/28/1999 - "Over the period of the last three to five years, studies of the specific mutations responsible for these syndromes and the cellular signaling pathways disrupted by the mutant proteins have begun to provide unprecedented insights into the molecular origin and pathogenesis of inherited and sporadic forms of cancer. "
3. Huntington Disease (Huntington's Disease)
09/01/2008 - "We also report the growing list of new drugs/pathways that upregulate autophagy to enhance the clearance of this mutant protein, as autophagy upregulation may be a tractable strategy for the treatment of Huntington's disease."
01/01/2015 - "This study increases our understanding of the effects of Huntington's disease on peripheral tissues, while further demonstrating the differential effects of the mutant protein on different but related cell types. "
07/01/2014 - "Huntington disease (HD) is caused by a genetically encoded pathological protein (mutant huntingtin [mHtt]), which is thought to exert its effects in a cell-autonomous manner. "
01/01/2014 - "The autosomal dominant inheritance pattern of Huntington's disease suggests the importance of the mutant protein, huntingtin, in pathogenesis of Huntington's disease, but wild type huntingtin also has been shown to be important for neuronal functions such as axonal transport. "
02/01/2012 - "The most robust suppressors reduced both soluble and aggregated Huntingtin levels, suggesting toxicity is likely to be associated with both forms of the mutant protein in Huntington's disease."
4. Cystic Fibrosis (Mucoviscidosis)
12/01/2015 - "There are nearly 2000 mutations in the CFTR gene associated with cystic fibrosis disease, and to date, the only approved drug, Kalydeco, has been effective in rescuing the functional expression of a small subset of these mutant proteins with defects in channel activation. "
11/01/2010 - "An improved understanding of the molecular mechanisms underlying the basic genetic defect in cystic fibrosis have led to new treatment strategies to repair the mutant protein."
04/01/2011 - "We analyse a paper, which reports an entirely novel approach to the treatment of cystic fibrosis, consisting in "repairing" the defective mutant protein. "
01/01/2003 - "Cystic fibrosis: premature degradation of mutant proteins as a molecular disease mechanism."
11/01/2001 - "A number of genetic diseases, including cystic fibrosis, have been identified as disorders of protein trafficking associated with retention of mutant protein within the endoplasmic reticulum. "
5. Renal Tubular Acidosis (Distal Renal Tubular Acidosis)
03/01/2002 - "The article discusses a likely mechanism for dominant distal renal tubular acidosis in which associations between the normal and mutant protein alter the plasma membrane targeting of the normal protein in the kidney."
06/01/2005 - "In vitro functional studies of these mutant proteins in cell expression systems have helped to elucidate the molecular mechanisms underlying renal tubular acidosis, which ultimately may lead to new therapeutic options in what is still treatment only by giving an oral alkali."
01/01/2013 - "Mutations in the SLC4A1 gene encoding the anion exchanger 1 (AE1) can cause distal renal tubular acidosis (dRTA), a disease often due to mis-trafficking of the mutant protein. "
Related Drugs and Biologics
1. Proteasome Endopeptidase Complex (Proteasome)
2. Alkalies
3. Phosphotransferases (Kinase)
4. Antigens
5. Antibodies
6. RNA (Ribonucleic Acid)
7. GTP-Binding Proteins (G-Protein)
8. Ligands
9. Single-Chain Antibodies
10. Proteins (Proteins, Gene)
Related Therapies and Procedures
1. Drug Therapy (Chemotherapy)
2. Liver Transplantation
3. Therapeutics
4. Heterologous Transplantation (Xenotransplantation)
5. Immunotherapy


As I mentioned in the previous post, I've recently been playing around with remastering some old recordings using Ardour. I thought I could use this space to document my recollection of the song, the recording and my experiences during the remaster.
For background, all of these recordings came from a recording session I did in 1990 as part of a band called Felix Amour. We built a recording studio throughout our house including installing a fully insulated soundproof chamber in the basement with cabling etc all run up through a return air vent to one of the bedrooms where we had the master control room. The control room consisted of our 24 channel mixer, our effects rack and a rented Fostex 8 track reel to reel recording unit.
The original recordings were very much 'album oriented' with each track fitting in for a particular part of the album; however, I'm not pulling them out in order. I'm randomly picking songs one by one to remaster, mostly based on perceived complexity of doing the remix. So far I think the songs stand up individually.
The first song I have attempted to remix was 'Home'. If I recall correctly, I wrote this song, ironically enough, when I was at home. The main chorus simply repeats the phrase "I want to go home"; however I think the question is, where the hell is that, exactly? With each repeating phrase, I seem to be getting farther and farther away from wherever that may be. We tried to keep the song as dead simple as possible, with the feeling of almost a funeral march at times. We also wanted the beats to be very much on the back, slowly trudging along on our way to somewhere - perhaps home, perhaps not. There was even a couple of parts that I remember trying to slow down even more (end of the second verse) to give the impression that at any given moment the song may lose all momentum and completely come to a stop. It ends with the rest of the band joining in the desperate parade (Dean Zimmerman on drums, Jeff Harrison on bass) with some nice guitar work by Wayne Russell.
The mix went extremely smoothly. I don't remember doing much editing, just cleaning the tracks and adding some effects/filters.
A note on file formats. I've have included a Flac version and an Ogg version. If you have never heard of these file formats, you should really get out more often. Both of these formats are completely open (non-proprietary) and are actually better than their proprietary cousins wav and mp3. Flac (like .wav) is 'lossless', meaning the quality is _exactly_ what is coming out of the mix. Ogg (like mp3) is 'lossy' meaning some quality has been reduced to minimize the file size. To play these in Windows Media Player, you'll need to install the libraries, else you can install Winamp as your player and use the the Flac Plugin.
If you really don't know how to install the plugins etc, you can (if you must) the wav and mp3 copies are available, although both the flac and the ogg will sound better than the mp3.
Feel free to add comments / suggestions about the mix, I'm always open to trying other things.
Actually, it appears the download links are broken temporarily. Should be fixed soon.
Thanks for sharing this - I've been curious about your music for years. I found it pretty challenging, which isn't a bad thing of course, but it took a couple listens to even figure out how it made me feel. It actually takes me back to the fall of 2003 after I'd left Parasun. Not sad, exactly. Homesick and melancholy. It's not a bad memory - just a challenging one.
It's interesting that you use the word 'challenging'. I'm not sure the exact context you are using the word, but I would agree that there is a 'challenging' aspect to our music. Much less so with this song, but overall we didn't write many 'verse-chorus-verse-chorus-bridge-chorus' songs... in fact, I'm noticing that for some of our songs its difficult to pick out which is the verse and which is the chorus. I guess that was intentional but probably unfortunate. This isn't to say I wish we wrote easier songs, but I'm not sure we considered the craft. For some reason I associated 'accessible' with 'sell out', which isn't necessarily the case at all. I mean look at the Beatles - they wrote some of the most complex (especially for the time) but deceivingly easy sounding songs ever.


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Surrounded by mountains on three sides, Jinhua combines its spectacular natural scenery with an ancient past and rich cultural traditions. The city dates back to the 2nd century BC and is known for its tranquil temples, world-class opera and water-filled caves.
Discover the sacred Wong Tai Sin Temple and learn about the Chinese Taoist Deity, a god said to possess the power of healing. Constructed in 1921, the temple is a tranquil place and beautiful example of traditional Chinese architecture. If you're lucky, you may be able to witness a ceremony.
Visit Shuanglong Scenic Area and venture inside the Double Dragon Cave. Two stone dragons guard the entrance to the limestone cave, which is filled with illuminated stalactites. If you're feeling brave, take a boat into the inner chamber and witness two eight-metre-high surging waterfalls.
Explore a fascinating display of architectural talent at Jinhua Architecture Park, set on the banks of Yiwu River. The park is dedicated to famous poet, Ai Qing, and contains 17 innovative buildings designed by Chinese and international architects. For a glimpse into Jinhua's past, meander down "Old Street", a narrow lane filled with traditional buildings and an outdoor antique market selling old coins, wood carvings and jewellery.
Do you love the opera? See a performance at the Wuju Opera theatre, the second largest opera group in the Zhejiang province. Admire the colourful silk dresses, painted porcelain faces and delicate finger poses, then be thrilled by an exhilarating display of song and dance.
Yiwu International Airport is one hour's drive or bus ride from Jinhua. Buses and railways connect Jinhu with Shenyang, Wenzhou, Nanchang and Shanghai. Jinhua is easily explored on bicycles and e-bikes, but buses and trains are also available.
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132 reviews rated Wanda Realm Jinhua with an average score of 8.1/10. It may also be worth looking into the Shangri-La Hotel, Yiwu, which received a rating of 8.9/10 from 325 reviews. Relax Hotel could also be a good option, with a score of 7.3/10 from 14 reviews.


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By Dave Smith - posted Friday, 12 August 2005 Sign Up for free e-mail updates!
Ray's sentencing took place on Friday, April 15, 2005.
In the month or so between Ray's hearing and his sentencing a lot happened, to me at any rate. For one thing, I found out for myself the circumstances that had determined the collapse of HIH. It was quite bizarre. I never expected, nor felt I needed to know, the intricacies of what led to the crumbling of the once mighty insurance empire. This wasn't because the collapse meant nothing to me. Indeed, I too had been affected by it. At the time HIH fell, Ange and I were being sued by a guy who broke his leg in a wrestling class (see that story here) and we found ourselves uninsured and facing possible bankruptcy.
For Ray's sake also, I had tried to educate myself on the situation, reading the papers and working my way through one enormous book written on the collapse of HIH. I knew the key to the collapse had been HIH's purchase of FAI. They had paid far too much for it, apparently unaware of some significant liabilities that for some reason didn't come to light until after FAI had been sold. Even so, my interest was more in the man, Ray Williams, than in his business.
Then I stumbled upon the truth quite fortuitously. It came about because a friend of mine, totally unrelated to Ray, had been associated with another major player in the HIH drama. This friend phoned me up one day and told me this key player had been looking for a priest to confess to. I have to keep it vague like this, as I'm told that even now, this person or others involved in the drama could still use any clear statements I make not only to sue me but to get themselves acquitted if they are ever brought to trial. I don't know whether this would really happen or not, but I have so little faith in our legal system, I have no desire to put the matter to the test.
Anyway, to cut a long story short, I didn't personally take the confession, but I did find out what happened. Let's just say when HIH bought FAI, things had been deliberately covered up and money had changed hands. One of the key players financed the cover-up, another brokered the deal and Ray had been kept completely in the dark.
When I took these details to Ray, he told me he'd already worked this out. He told me he'd initially been perplexed as to why one of his former key associates had produced such a damning testimony against him during the Royal Commission into the HIH collapse. A testimony he said was full of lies. Then it clicked to him that this guy must have been covering up something himself.
I said to Ray, "But now we know the truth, isn't there someone we can tell?"
"No," said Ray. "The truth is not going to do us any good at this stage."
Again, this highlights the nature of our legal system. Truth is never really an issue. The legal game is a boxing match, fought out between two opponents, with the judge acting as referee. Truth is an extraneous extra party. It really has no place in the judicial ring.
Looking back, Ray never stood a chance. He was a lightweight taking on a heavyweight without a conscience: the Australian Government. That heavyweight had the Australian media working their corner. Never was the mismatch clearer than on the day of Ray's sentencing.
I turned up to court feeling optimistic. I'm embarrassed to admit that now, but the hearing had been so exceptional and I figured in the end the judge was a human being and had to be affected. Besides that, I'd been saying plenty of prayers, as had the good people of our parish, and surely that should amount to something.
I entered the court building, looking for the private room near the foyer where I knew Ray would be gathering with his friends and family. To my surprise, though, I found Ray standing outside the door of the room with a sobbing woman in his arms.
1 post so far.


TIP! Are you stressed about learning as much as you can in a short time span? Work at it slowly and steadily if you want to be successful. Set aside some practice time every day, and over time you will learn the skills you need to have.
Have you ever cluched a guitar in your hands and wished you could play it? Have you not done so because you don't think you're any good at music? Fret not; anyone can learn how to play with the right information. Read on for more information about the guitar.
TIP! While it might seem intuitive, you need to get yourself a guitar in order to learn to play one. If you do not own a guitar, regular practice is difficult.
Learn all the basics. In order to play those involved pieces, you must first learn about the basics. Even though you may wish to play your favorite songs now, you must learn the basics at the outset. Also, determine where your fingers should reside on the guitar. You will want to pay attention to the chords you need to learn as well as scales. Be sure you're able to do these things easily before you move on to advanced stuff.
TIP! Be sure you're having fun while you practice playing the guitar. Remember that you are doing this because it is something that interested you.
Find ways to stay motivated. You should create both short-term and long-term goals for your guitar playing. Practice the guitar with a friend. Give yourself a reward when you hit your goals. Remember that little in the world is easy.
TIP! When you begin playing guitar, do what you can to get a quality one for practice. If you can't purchase your own, try to rent or borrow one.
Make practicing the guitar fun. Do this only if you want to. You shouldn't dread practicing. If you do so, you can frustrate or bore yourself enough to give up on the practice. Play and practice songs or pieces that you enjoy.
TIP! Learn about the various parts of your guitar prior to starting to learn to play it. In order to learn basic things, such as scales and chords, an understanding of the fundamental parts of a guitar is needed.
Prior to even picking up the guitar, teach yourself the names of the parts. This makes it easier to play since you'll understand what scales, chords, and string names are.
TIP! Figure out how to play in different keys. Learning to play one song in a lot of keys will allow you to learn quite a few chords.
Before you get callouses on your fingers, you might have sore fingertips. It may hurt less playing a nylon-string or electric guitar. Acoustic, steel-string guitars are often the most painful for beginners. You can ease the pain in your fingertips by soaking them in rubbing alcohol. Don't follow old wive's tales that tell you to use dangerous liquids, such as turpentine.
No matter what sort of music you like, start with simple techniques. Try easy songs to start with. Children's songs are a great place to start.
TIP! Try not to overspend on your first instrument. You may get excited and think you should get a pricey guitar, but this isn't something that you should really do.
Learn how you can play a song in different keys. When you experiment with different keys, it can help you learn the chords of the song more easily. It also helps you to understand music better. This will make you a better musician.
TIP! Always know when a break is necessary. Yes, you should practice daily but understand, too, how not to get burnt out.
Buying a metronome would be a wise purchase. This can help with the tuning of your songs. With a metronome, you won't have to waste time worrying over whether you have the right tempo. You can learn the song at slower speeds and pick up the pace when you're ready. The use of a metronome will increase the effectiveness of your practice.
Begin gradually. Take fast songs slowly. It's important to learn the song itself first. Begin slowly and get the hang of every note before quickening your pace. With only a focus on speed, your frustration with mistakes will be increased. So, it is better to start things off very gradually, learn the song, and then let the speed come to you.
Make your fingers strong by doing exercises. Some chords need flashy handwork, but you can only do this once you're able to control string with your fingers. Strengthening your hands and fingers with certain exercises will help you play the guitar better.
TIP! Before looking songs up, try figuring them out. Playing by ear is a talent and can really better your guitar playing skills.
Chord switching is important when learning to play guitar. Dedicate a part of your practice time each day to this alone. Moving agilely from chord to chord will keep the music fresh and enjoyable rather than screechy and loud.
TIP! Practice strumming your guitar regularly. This helps with learning chords and their various combinations.
Find the right times to take mind breaks. Do not burn yourself out while playing. You want to maintain your motivation. If you have practiced daily, try to avoid playing guitar for a couple days. Taking a break can restore your interest. However, don't take a break too often.
TIP! Your amp should be used with a pair of headphones. Some people prefer using an amp when they play.
There are different products that can help your fingers feel better as you begin playing the guitar. Use apple cider vinegar to soothe your fingers. You may also be able to ease any soreness if you ice your fingertips lightly. It can help to apply benzocaine before playing.
Strumming is important. This can help you learn chords and after you have learned the chords, it will be easier to combine them. This will also help with your transitions. Therefore, it is important to spend time strumming if you want to be a better guitar player.
TIP! Learn how to use a pick correctly. Picking up the pick is an important part of learning guitar.
If you're using an amp, consider using headphones. Many people prefer using an amp. This isn't always the practical approach. Not many people live somewhere where people like to hear this kind of noise. When noise is a concern, get yourself the headphones and use them.
TIP! Think about the type of music you're going to play on your guitar. The type of guitar you get will depend on what style of music you like.
Practicing a duet with a friend can help you to learn. One can play the chords, and the other can play the main melody. You can practice technique in a fun way! It also makes you better at creating a steady tempo and rhythm since you'll be playing with someone else.
It is important to learn to use guitar picks correctly. Using a pick correctly will help a lot. Be sure you're not forming habits that aren't good when you start out. Figure out how you should hold your pick in the right way. Use different picking patterns and always play with one.
When considering playing the guitar, determine what type of music you'd like to play. The style that you want to play will help you to decide on a guitar. Classical music lovers will probably gravitate toward acoustic guitars, while contemporary music fans will likely want an electric or steel guitar.
TIP! Mastering the guitar, like anything else, requires practice. Muscle memory is important.
Be careful when buying cheap guitars online. A guitar is something that needs to be held and touched to see how it feels in your hands. If you don't think it feels good, then you won't be getting a bargain at any price.
TIP! If you are drawn to computers, there are guitar programs that can instruct you on how to play. This can connect to your guitar during the lesson.
Now that you've read this, you should see that it's not that hard to learn guitar. In no time at all, you can at least pick up the basics. With some dedicated practice, you'll be playing your favorite songs quicker than you think.
TIP! Try getting some lessons from a teacher. You can learn to play the guitar on your own, but you can also benefit from learning from a teacher.
Learning to play a guitar is an excellent decision. Whether you want to self-teach or take lessons, you can do a ton with the guitar. Use this helpful information to get you started playing the guitar.
TIP! Try to stay motivated. Setting short and long-term goals can be helpful for new guitar students.
If you've decided to learn the guitar, make sure you have easy access to an instrument. They may be out of your price range, but think outside the box. It is possible to rent these instruments or to find one used on the Internet. Using a quality guitar will ensure a better sound.
TIP! Don't forget to have fun with learning the guitar. Remember that the reason for learning guitar in the fist place is because you have always wanted to.
Wanting to play a guitar? Try to build up calluses on the tips of your fingers. This will mollify the pain that you feel. While it does take time to build those callouses, practicing often will help you develop them. There are even callus-building products out there.
TIP! Before you start playing your guitar, take the time to learn all about it. You will feel more confident as you learn and it will help you when talking to others.
Learn everything you can about each part of a guitar. Once you know the terminology and lingo, it will be easier for you to learn from the training manuals. You will become a better and smarter musician by doing so.
TIP! Your fingertips will get sore with constant practice. It might be less painful to start with an electric or a guitar with nylon strings.
You must understand the parts of the guitar before you plan on playing it well. This is going to help you become familiarized with your instrument as you start to learn scales, chords and string names.
TIP! You can buy a metronome. Keeping time is a real challenge for novice players.
You may get sore fingertips before they develop calluses. It may hurt less playing a nylon-string or electric guitar. Steel-stringed guitars will hurt the most when you play. It may help to soak the tips of your fingers in rubbing alcohol, but don't use stronger or harmful substances, such as turpentine.
TIP! No matter what sort of music you like, start with simple techniques. Steer clear of complex songs and start with some easy tunes.
Whether you enjoy rock and roll or classical guitar, it is important to start simple. Steer clear of complex songs and start with some easy tunes. Single-note melodies and simple children's songs will give you a good foundation to build on.
TIP! Try different keys when learning how to play your favorite songs. If you do this, it will help you understand the different chords.
Try different keys when learning how to play your favorite songs. This can help you to properly manipulate the different chords. It will also help you with your understanding of music. This is one thing that will help you grow as a musician.
TIP! Get yourself a metronome. Using a metronome will allow you to get better at timing and your rhythm.
TIP! Find a guitar buddy. Ask someone else who likes similar styles of music if they want to practice.
Play with a friend. You can ask someone with more technical skills than you to join you in jam sessions. They can show you techniques that you may not have learned yet. Besides, it is fun to learn and to play guitar with the people you care about. You can also find a practice buddy who is at the same level of skill as you and you can share techniques and help each other out.
TIP! Use products that can help with the pain from playing. When playing the guitar, use apple cider vinegar as a soak prior to playing and after as well.
Take advantage of some common household products to relieve finger soreness as you learn to play. Soaking your fingers with apple cider vinegar a minimum of 30 seconds before and after playing helps. Applying ice to your fingertips is also a good way to ease soreness. Using a product that has benzocaine in it prior to playing and afterwards can help a lot.
Try doing songs by yourself before looking at tablature. The Internet has made it easy for you to learn almost any song out there, but try to use your ears and listen for yourself and see if you can figure it out before you do an online search.
TIP! Practice strumming your guitar. That way, you will learn chords and start blending them properly.
Learn to strum on a guitar. That way, you will learn chords and start blending them properly. In addition, it will aid you in making a smooth transition from chord to chord. So, devoting time to strumming helps improve your playing in the long run.
TIP! Once you have purchased your guitar and begun to learn, do not forget to keep it in good shape. Understanding the right way to clean and care for your instrument will make sure it has a long life.
Headphones are something that you may want to use. Many people favor the idea of playing with amps. This is not always the most practical choice. All of the noise from an amp may be too much for where you live. If the noise can be bothersome, invest in headphones to use as you play.
TIP! Inspire yourself with instrumental music featuring the guitar. When you physically hear how good the professionals are, you're going to be motivated to play better than you do already.
Don't forget about the guitar pick. Using a pick correctly will help a lot. Try not to form bad habits, especially early on. Learn the right way to hold your pick. Play with a pick and try different patterns for a challenge.
TIP! Try learning guitar with friends. Ask around to see if anyone else would like to pick up the guitar at the same time as you.
Consider what your "style" is as a musician. The guitar you decide on should be based on the main kind of music you are into. For instance, classical music is usually played on an acoustic guitar, while contemporary music is played on a steel string or electric guitar.
Being able to read and comprehend music and play well is wonderful. However, it is equally important to train yourself to play by ear. This means you'll know how to play a tune just by hearing the song. You are far more likely to be a great musician if you can play by ear.
TIP! Take the time to get familiar with your guitar by holding it, moving around with it and just generally learning to handle it with ease. This will help you to see it as an extension of yourself.
The best method for improving any skill is consistent practice. The benefit you can get from extensive practicing is muscle memory. As you use the motor skills and the muscles in your fingers, they start to operate without a lot of conscious instruction from your brain. You will be able to play more quickly and accurately this way.
Muscle memory is an important part of learning how to play. Even if you only devote 30 minutes to practice, you will gain much more than a weekly, three-hour session. Daily practice is what helps your guitar playing skills develop a habit.
TIP! Check out different guitar magazines to see if one is right for you. Receiving a monthly magazine that is devoted to guitars can help you learn more about playing.
Learning some music theory will make you a better musician. Learn the different chords and rhythms that constitute music. This teaches you more about the inner workings of scales and chords. Search for music theory books at the library, onlnie or a music store. You can learn to sight-read music and play anything!
TIP! Try out a bunch of different songs. You can expose yourself to a variety of styles and different ways to manipulate chords.
How are you feeling about playing the guitar? Take a moment to think of all your favorite songs you will be able to play! You're ready to start playing now. Apply what you have read here and enjoy one of the most versatile instruments in the music world.


text:
Stable-Label Intravenous Glucose Tolerance Test Minimal Model
Angelo Avogaro,
James D Bristow,
Dennis M Bier,
Claudio Cobelli and
Gianna Toffolo
Departments of Pediatrics and Medicine, Washington University School of Medicine, St. Louis Missouri Department of Electronics and Informatics, University of Padova, and Institute of System Dynamics and Bioengineering, National Research Council Padova, Italy
Address correspondence and reprint requests to Dennis M. Bier, MD, Metabolism Division, Box 8127, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110.
Diabetes 1989 Aug; 38(8): 1048-1055. https://doi.org/10.2337/diab.38.8.1048
The minimal model approach to estimating insulin sensitivity (SI) and glucose effectiveness in promoting its own disposition at basal insulin (SG) is a powerful tool that has been underutilized given its potential applications. In part, this has been due to its inability to separate insulin and glucose effects on peripheral uptake from their effects on hepatic glucose inflow. Prior enhancements, with radiotracer labeling of the dosage, permit this separation but are unsuitable for use in pregnancy and childhood. In this study, we labeled the intravenous glucose tolerance test (IVGTT) dosage with [6,6-2H2]glucose, [2-2H]glucose, or both stable isotopically labeled glucose tracers and modeled glucose kinetics in six postabsorptive, nonobese adults. As previously found with the radiotracer model, the tracer-estimated
derived from the stable-label IVGTT was greater than SI in each case except one, and the tracer-estimated
was less than SG in each instance. More importantly, however, the stable-label IVGTT estimated each parameter with an average precision of ± 5% (range 3–9%) compared to average precisions of ±74% (range 7–309%) for SGand ±22% (range 3–72%) for SI. In addition, because of the different metabolic fates of the two deuterated tracers, there were minor differences in basal insulin-derived measures of glucose effectiveness, but these differences were negligible for parameters describing insulin-stimulated processes. In conclusion, the stable-label IVGTT is a simple, highly precise means of assessing insulin sensitivity and glucose effectiveness at basal insulin that can be used to measure these parameters in individuals of all ages, including children and pregnant women.
Revision received February 23, 1989.
Accepted February 23, 1989.
August 1989, 38(8)
You are going to email the following Stable-Label Intravenous Glucose Tolerance Test Minimal Model
Angelo Avogaro, James D Bristow, Dennis M Bier, Claudio Cobelli, Gianna Toffolo
Diabetes Aug 1989, 38 (8) 1048-1055; DOI: 10.2337/diab.38.8.1048
Intravitreal Triamcinolone Acetonide Inhibits Breakdown of the Blood-Retinal Barrier Through Differential Regulation of VEGF-A and Its Receptors in Early Diabetic Rat Retinas
Improved Glucose Tolerance in Zucker Fatty Rats by Oral Administration of the Dipeptidyl Peptidase IV Inhibitor Isoleucine Thiazolidide
Fibronectin Fragments Modulate Human Retinal Capillary Cell Proliferation and Migration
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Born, partly out of the frustration of trying to find post-graduate exhibition spaces, BasementArtsProject came into being in 2011. At first, using the basement of a terraced property was a practical solution, but over the years it has become the cornerstone and foundation of an expanding practice that thrives through its interactions. Exhibiting at BasementArtsProject has become, mostly by chaotic accident, more than a gallery experience, it is about becoming part of a family, a real one that resides in and around a permanent art space.
A family is based on relationships, and both artist and audience have no choice here but to interact. Here the hushed polite tones of a white-walled space are absent, instead the domesticity of tea and biscuits and free lunches encourage questions, discussion and curiosity from all sides, including those who may not have previously experienced art. This exhibition space has a direct interest in and understanding of the community in which it lives, acquired from living, working and raising children among its citizens. It is BasementsArtsProjects intention to offer art hospitably to Leeds and the rest of the world, but especially to its locality.
BasementArtsProject develops relationships with undergraduates, graduates, and established artists, some from the UK and others from much further afield, none are exempt from the hustle of working within a family home and this warm chaos extends to those who come to engage with the art works. It is through the unique relationships that we build with artists offering advice, assistance, a place to work and exhibit, and oSen a place to stay that we are able to create lasting and meaningful partnerships.
BasementArtsProject has an Open Submissions policy alongside that which is commissioned by ourselves. The programme is determined by the relevance of projects to the space and the ability of the artists to work under challenging circumstances. The basement is a very singular environment that promises great rewards to those that can think laterally about their strategies for exhibiting. The ground floor of BasementArtsProject stands as a living testament to the work that has happened here over the years, with works by many artists adorning its rooms and hallways. The collection often provides many interesting secondary stories for visitors to the main exhibition. Because of the intimate nature of the environment visitors gain great insight into the work of the artists through direct contact and a familiar environment.
Eventually BasementArtsProject hopes to be able to convert the basement into a space that can be lived in whilst still being used as an exhibition space. This would allow us to bring artists from further afield for longer. We also conceive that the Leeds BasementArtsProject could be just one of many similar spaces located in different parts of the country (world?) sharing resources and connecting communities and artists whilst providing a supportive environment in which artists can progress.
BasementArtsProject may be small in scale but its ambitions are grand.


Blue Barn's sunny county decor.
With artfully faded wooden siding and barn-style rafters and pitchforks mounted on the wall, Blue Barn is a country-style decorated restaurant located conveniently at the heart of the Corte Madera Town Center, a 10-minute drive from Tam. Blue Barn has become increasingly popular since it came to Marin in early 2012, having already opened two locations in San Francisco. A business member of Marin Organic and part of the "slow food" movement (as opposed to fast food), Blue Barn caters to both fine cuisine and healthy eating initiatives, both of which have strong roots in Marin County.
The Corte Madera location has a partially open kitchen, which allows customers glimpses of the panini presses. Customers order at the counter and then seat themselves.
The service is good, but the food is slow to come. There is a sign above the counter that says, "slow food takes time," as well as a warning in the handheld menu that the grilled cheeses should be expected later than regular sandwiches. Blue Barn is definitely a place to sit and savor your meal to tasteful background music, but the food can be packed to go if you need to get back to yout third period class.
Open for lunch and dinner (11 a.m. to 8 p.m. daily), Blue Barn is often packed with hungry Marinites. The seating area is on the smaller side, but there is additional space outside. Because of the restaurant's popularity and culinary excellence, customers are likely to run into a crowd.
Blue Barn is also a pricey option, especially for high school students. Their most expensive sandwich, the Spicy Tuna ($14), consists of Ahi tuna, mixed greens, and ginger vinaigrette. Their least expensive dish is a house falafel with feta cheese ($8.75). There is also a kid's menu that features several smaller items including an organic PB&J ($5).
Although the price is high, the quality of the food reflects the cost. The bread, which comes in many different varieties from whole wheat to country levain, is always fresh. When scanning the menu, customers will run into similar types of ingredients: gourmet cheeses, aioli sauces, arugula, sundried tomato and avocado. Much of this produce is locally grown by Oak Hill Farms in Sonoma, or by a nearby family-owned farm.
Blue Barn is a good restaurant if you're looking to let your taste buds explore new options. Many of the combinations as are eye-opening as they are delicious. The grilled cheeses are really more like paninis and, although they are cooked in oil on a press, are not greasy in the slightest.
I'd recommend the Provo grilled cheese ($10) made with provolone cheese, turkey, avocado, tomato, arugula, and thyme aioli, to anyone who appreciates the proper use of avocado. If you like barbeque sauce, the Kickin' Chicken sandwich, which features both grilled chicken and bacon, is the way to go.
Although there is meat on almost every sandwich, vegetarians have the option of ordering salads or, thanks to the flexible kitchen staff, asking for the meat to be left off. Blue Barn creates an open atmosphere, with many doors and windows through which the Marin sun shines. The mood is easy-going because everyone is understandably happy to be eating there. The next time you're in the mood to try something new, consider heading over to Corte Madera for a sandwich. You may discover your next favorite food.


Though estimate tolerance rules have been around before TRID, "good faith," tolerances, and refunds/cures seem to still be a challenge for many lenders and creditors. This is concerning as tolerances/cures are one of the higher-risk areas (like rescission) that creditors really need to ensure they are doing appropriately as deficiencies can result in significant fines, penalties, and enforcement actions.
In reviewing the challenges related to calculating "good faith" and providing appropriate refunds/cures, it appears that there still seems to be quite a bit of confusion relating to how a creditor must calculate tolerances in the 10% tolerance bucket.
Under TRID, creditors must disclose - in "good faith" - an estimate of their fees for a credit transaction. This means that a fee is considered to be in "good faith" if the actual fee charged to the customer (on the final Closing Disclosure) does not vary by more than a specified amount from what was disclosed on the original Loan Estimate, or a revised Loan Estimate if applicable. The standard for "good faith" actually varies from fee to fee, but Regulation Z essentially provides three different levels that are used to determine whether or not a fee was disclosed in good faith: the zero tolerance bucket, the 10% tolerance bucket, and the unlimited bucket. In other words, a fee will be considered within tolerance if it does not change by an amount more than the amount allowed in the specific bucket (0%, 10%, or unlimited) based on the type of fee and its associated tolerance bucket.
One of the biggest challenges in understanding the 10% tolerance rules is realizing that the fees used for the good faith tolerance calculation may not always be the amounts quoted on the original Loan Estimate as the fees may change during the course of the loan. As we have discussed before, there are a number of reasons (e.g. changed circumstance) why a revised fee may be used in place of the fee amount quoted on the original Loan Estimate. A revised fee, however, can only be used in calculating good faith if it is appropriately disclosed on either a revised Loan Estimate or Closing Disclosure.
While one might think that resetting the tolerance for the 10% bucket would seem easy, the rules actually make it a bit complicated. In fact, the rules state that the 10% bucket cannot be reset unless the amount of the change is more than 10% of the aggregate amount of all fees in the 10% bucket. For example, if all of the originally disclosed fees that go in the 10% bucket total $1,000, this means that the 10% bucket can only be reset if the aggregate change is more than $100. The result of this rule is that, even if a creditor receives a valid changed circumstance that increases fees by $90 (when the original amount of fees in the 10% bucket were $1,000), the 10% bucket does not reset and the tolerance amount remains $100 off of the original $1,000. This means that the final fees are still limited to $1,100 and any amount exceeding this must be refunded to the customer. This can be confusing as there was a valid changed circumstance, but the amount of increased fees did not exceed 10%, meaning that the valid changed circumstance did not reset the tolerance amounts used for calculating good faith in the 10% bucket.
If however, a changed circumstance were to increase fees by more than the original $100, such as by $150, then the 10% bucket would be reset so that good faith is calculated off of $1,150, meaning that the final fees can increase by $115 for a total of $1,265 ($1,150 + $115) before a refund (cure) would be required to the borrower.
It is also important to keep in mind that if a disclosed fee/service listed on the Loan Estimate that was originally in the 10% bucket is not purchased, then it has to be removed from the total amount in the 10% bucket for good faith comparison purposes. For example, when a survey fee is disclosed on the Loan Estimate, that fee starts off in the 10% aggregate amount. If that survey is never obtained, meaning a fee was never charged, then the amount of the survey from the original LE is removed from the 10% bucket when calculating the final 10% good faith tolerances. In other words, the rules prohibit lenders from "padding" the 10% bucket by quoting fees/services that may not actually be obtained.
Similarly, if a fee disclosed on the LE starts off in the 10% bucket but ultimately moves to the unlimited category – such as when an applicant chooses their own service provider – the amount of the associated fee is not included in the aggregate amount of the 10% bucket. Rather, that amount moves to the unlimited bucket.
In fully understanding the 10% tolerance rules, it is important to realize that the 10% bucket can be reset aggregately, when multiple fees in the 10% bucket change at different times. For example, if an initial changed circumstance changes a fee by 7% and a second changed circumstance changes a fee by 6%, the combined change of 13% is enough to reset the 10% bucket - if a revised Loan Estimate is appropriately provided to inform the applicant of the revised fees.
The question, of course, is this: when must a revised Loan Estimate (or Estimates) be provided to the customer in order to be able to reset the 10% bucket?
Question - I was re-reading the commentary for 1026.19(e)(4)(I) and was wondering if our prior understanding of re-issuing LE's due to a valid COC is correct. I thought that if you have a valid COC that doesn't tip the 10% bucket, say it's increases it by 5%, then there's a subsequent valid COC, that tips the baseline by another 6%, in order to have the cumulative tipping effect, we had to have had re-disclosed a revised LE with the first valid COC within 3 business days of receiving such information, and then again at the 2nd COC, and the revised 2nd COC then becomes our baseline. But in re-reading the commentary, it appears so long as we issued a revised LE within 3 business days of 2nd COC, we are fine and can re-set our baseline even if we didn't issue a revised LE for the first valid COC since it didn't tip the bucket.
I love the way this question is asked as many creditors seem to have been under the impression that a revised Loan Estimate was required for each changed circumstance when a fee increased, even if the fee did not increase by more than the aggregate 10% amount. In reality, this is not the case as a single revised Loan Estimate can be used to reset the 10% bucket. Also, to clarify, TRID 2.0 did not change these rules.
This confusion seems to be, in part, because the rules are not as clear as they could be and because some have taken the conservative approach by providing a revised LE for each changed circumstance, which is technically permitted, but not required. To explain, the original version of TRID did (but not clearly) provide two main examples clarifying that a creditor can "reach back" to prior changed circumstances and just issue one revised Loan Estimate, once the aggregate increases exceeded 10%. In other words, TRID has always permitted a creditor to "reach back" to prior changed circumstances where a revised Loan Estimate was not provided because the aggregate changed fee(s) associated with the changed circumstance did not exceed the 10% amount to reset the bucket.
"ii. Assume a creditor receives information on Monday that, because of a changed circumstance under § 1026.19(e)(3)(iv)(A), the title fees will increase by an amount totaling six percent of the originally estimated settlement charges subject to § 1026.19(e)(3)(ii). The creditor had received information three weeks before that, because of a changed circumstance under § 1026.19(e)(3)(iv)(A), the pest inspection fees increased by an amount totaling five percent of the originally estimated settlement charges subject to § 1026.19(e)(3)(ii). Thus, on Monday, the creditor has received sufficient information to establish a valid reason for revision and must provide revised disclosures reflecting the 11 percent increase by Thursday to comply with § 1026.19(e)(4)(i)."
"In other words, if, for example, the creditor receives information on May 1, that a fee included in the ten percent tolerance category will increase by an amount totaling six percent of the originated estimated sum of charges in the ten percent tolerance category, and then on May 8th, the creditor receives information that a changed circumstance will cause a different fee included in the ten percent tolerance category to increase by an amount totaling two percent of the originated estimated sum of charges in the ten percent tolerance category, and then on June 15th the creditor receives information that a changed circumstance will cause a different fee included in the ten percent tolerance category to increase by an amount totaling four percent of the originated estimated sum of charges in the ten percent tolerance category, to comply with § 1026.19(e)(4)(i), the creditor would have to provide revised disclosures reflecting the 12 percent increase by June 18th, assuming that June 16th, 17th, and 18th are business days for purposes of § 1026.2(a)(6)."
The bottom line is that a creditor can provide a (courtesy) revised LE for each changed circumstance that does not individually increase the fees by more than 10%, but you are not required to. If you eventually have an aggregate increase of more than 10% and want to adjust your fees, then, in order to adjust your fees and not be required to refund/cure the customer, you must provide a revised LE with the 10+% increase (i.e. the aggregate changes) within 3 days after the last changed circumstance that increased the aggregate amount over 10%. If a revised Loan Estimate is not provided with 3 days after the last changed circumstance that increased the aggregate amount over 10%, the creditor has forgone their opportunity to increase the associated fees and cannot do so at a later time.
Jan 18 Quarterly Compliance Update Now Available!


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HPE continues its track record of SAP success by w...
HPE continues its track record of SAP success by winning yet another partner award
EIC_Alliances
By Urs Renggli
This year, it is the SAP® North America Partner Excellence Award 2017 for SAP HANA Technology Innovation. This award recognizes top-performing SAP partners in the North America region that have made outstanding contributions to driving digital transformation for HPE – SAP's mutual customers.
HPE has won partnering awards from SAP on a yearly basis, including the Pinnacle Platform Co-Innovation Partner of the Year, Rapid-Deployment Partner of the Year, and many more. Just last year, HPE came away with the SAP Pinnacle award for "Customer's Choice – Build."'
Not the first award, nor the last
The reason for this impressive winning streak is simple. Throughout the course of our 30+ relationship, HPE and SAP have perfected the process of developing and delivering solutions that are an ideal match for our customers' needs. This is clearly reflected in our current portfolio of assets that helps customers combine the right-fit infrastructure, software, and services to create an integrated Digital Core (i.e., S/4HANA) that:
Simplifies and consolidates IT landscapes and applications
Reinvents competitive business models to drive new revenue and profits
Provides real-time insights into all business processes to reveal new opportunities
Delivers the agility needed to change at the speed of business
Optimizes business services and user experiences
How and why SAP chose us
Candidates for this year's "SAP Partner Excellence Awards" awards were selected from SAP's wide-ranging partner base. Nominations were ns for the SAP Partner Excellence Awards were based on internal SAP sales data. A steering committee composed of regional and global SAP representatives determined winning partners in each category according to numerous criteria such as sales achievement and performance. Awards were presented in a variety of categories, including overall sales, innovation, technology, services and solution-specific areas.
As for HPE's award, Rodolpho Cardenuto, President, Global Channels & General Business, SAP, stated: "I am extremely pleased to recognize and congratulate Hewlett Packard Enterprise as the recipient of the SAP NA Partner Excellence Award 2017 for SAP HANA Technology Innovation. Hewlett Packard Enterprise demonstrates the values, commitment and amazing work that allows them to continuously deliver at the highest level. We look forward to continuing to work closely with our partners to grow their opportunities with SAP and to jointly deliver value for our customers."
We received the award during the SAP Field Kick-Off Meeting Las Vegas.
The real winners: our customers
Although the award itself lists HPE as the winner, we feel that customers like you are the ones who come away with the real victory. You and your business are the true beneficiaries of the advanced joint solutions available from HPE and SAP. To see exactly what you can win, check out the HPE – SAP Alliance site. To collect your "winnings," contact your HPE or SAP representative.
Urs Renggli is part of the Corporate Strategic Alliances team at HPE. As Evangelism Lead for the EMEA region, he works closely with a number of strategic alliance Partners, including Microsoft, RedHat, SAP and VMware. Urs has over 26 years of experience in the IT industry, including 20+ years in a variety of different marketing, sales and alliance leadership roles at Compaq, HP and HPE. He also spent 6 years in a number of regional and global roles at Microsoft Corporation.
HPE Alliance Partners


Check out the amazing images from The Photogenic Lab and fall in love with this fall affair just like we did!
Our stunning dining tables featured the most lovely flowers designed by the talented Somerset Design. Natural elements like pheasant feathers and maple leaves were an interesting, unexpected element against these bold blooms to make each arrangement (& the floral garland!) especially noteworthy. Gold table settings were finished with place cards which added a pretty, personalized touch. Very proud of these locally foraged fall leaves, spray painted gold & hand lettered by yours truly!
As always, we couldn't have enjoyed such a successful evening without our amazing team of vendor partners! Thank you so very much!
DJ: DTP Events "DJ DIGI"


Most economic activity takes place in cities, so cities are wealthy. But, not all cities are made equal.
Many nation states have a history where political/cultural power was first consolidated in a "core territory" and then extended outwards (think: Muscovy, Paris, or Bangkok). The outlying regions had different cultural, religious, and sometimes linguistic heritages but over time they were assimilated (sometimes by force/purges) and economically integrated into the core (sometimes by expensive infrastructure projects). However, everything redirects back to the core. When a territory like Brittany becomes "French" over the course of the 15th-18th centuries, it's not like joining a union or confederation: it's a subordination to Paris. The preponderance of economic and political activity stays in the core, the primate city (a "city far above all other cities"). The phenomenon of primate cities is very clear when you look at for instance this population cartogram of France or this one of Thailand. Now you can see why, e.g., DeGaulle spoke of the liberation of Paris as if it were the liberation of France.
Jefferson foresaw that the Midwest would become this huge, integrated economic region with trade and exports facilitated by the magnificently navigable (seriously, it's like it was designed) Miss-Oh-Missouri river system.
So all of this goes back to your question about "Red States" and "Blue States." Because of the specific settlement pattern of the USA, we have a relative abundance of states with regional cities. These cities were founded on the heads of navigation or the important points of confluence in the Miss-Oh-Missouri River System. For example, Cinci and Pittsburgh and St Louis are classic examples of these cities that grew up around the river trade and remain economic regional anchors today. These regional cities can "balance out" a relatively large and sparsely populated rural region, resulting in a swing state. If the regional city is too large, the rural areas simply get outvoted: Illinois is a good example of this. If a city gets lumped in with "too many" rural voters then it gets outvoted, as the reliable Democratic voters of Norleans get outvoted by their rural cousins. When they balance each other perfectly, then you get a so called swing state but always remember that this is talking about a moment in time. For example in 1997 (the latest we are allowed to talk about) Missouri was the bellwether swing state of the whole nation and voted exactly in line with the overall result in election after election, but, if I can skirt the rules, "then was then and now is now," nuff said.
The solid red states that are poor, that you're thinking of, are states that simply don't have a large regional city. They have mostly rural areas and a few sub-regional cities. An excellent example of this is Mississippi. The largest city in MS is Jackson, which is the 148th largest city in the USA - it's way down the chart.
If you were given liberty to redraw US State borders you could arbitrarily create "red" and "blue" states in any region of the country. It's just a matter of how much mashed potatoes (countryside) you put with your peas (cities).
This is good context for the Midwest, but there are definitely examples, especially in the West, of highly urban states that have been or are red rather than blue. Arizona, Colorado, Utah, Nevada, and Texas all come to mind as highly urban states that have swung back and forth in some cases or stayed staunchly red in others. There are today, and have been historically, conservative cities in the US--even very large cities (Houston, Dallas, Phoenix, Salt Lake City). I guess what I'm saying is that urbanization alone doesn't explain the historical (or current) distribution of red and blue states.


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trending Market Intelligence /marketintelligence/en/news-insights/trending/sFut3ZxCC2B-gstcIriD0A2 content esgSubNav
Liberty Utilities presents $340M pipeline and LNG storage project
6 Dec, 2017 | 16:04
Author Sarah Smith
Liberty Utilities Co. has proposed a $340 million natural gas pipeline and storage project in New Hampshire to shore up the utility service territory's access to gas.
The project, dubbed Granite Bridge, would include a $117.5 million, 16-inch gas pipeline that would run roughly 30 miles and a $222.5 million, 2-Bcf LNG storage facility. Liberty Utilities announced the project in a press release.
Both the New Hampshire Public Utilities Commission and the New Hampshire Site Evaluation Committee will need to give approvals for the pipeline. Liberty Utilities said it plans to file for approval with the PUC before the end of this year and with the Site Evaluation Committee in 2018.
The company expected the pipeline to take two years to build and the LNG facility to take two to three years once all project approvals are in place.
The utility's service territory is currently supplied by a single pipeline, company spokesman John Shore said in a Dec. 6 email. "This pipeline has constrained capacity and because of growing demand and based on our projections of future growth, we need to find additional natural gas capacity," Shore said. "If we don't bring added capacity to our service area, we could be turning down new requests for gas service in as little as just a few years. This would severely hamper economic growth in New Hampshire."
In the past 15 years, New Hampshire has seen a marked increase in the use of gas for power generation, while retaining gas demand in the residential, commercial and industrial sectors. The Granite Bridge pipeline would connect to the Portland Natural Gas Transmission System LP and Maritimes & Northeast Pipeline LLC joint facilities pipeline in Stratham, N.H., giving Liberty Utilities access to additional gas supplies from the Dawn Hub in Ontario and from LNG shipments to Saint John, New Brunswick.
The company asserted that the project is the lowest-cost option for improving reliability. It compared the Granite Bridge proposal to a $950 million alternative in which the company would expand an existing lateral. That expansion project would also require federal regulatory approvals, unlike the in-state Granite Bridge proposal, the company said.
Liberty Utilities said it would site the pipeline entirely within an existing New Hampshire Department of Transportation right of way and would avoid using eminent domain.


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ALFACOD has a Retail Division specialized in "ad hoc" solutions and products for department stores, for the retail segment and franchising. ALFACOD with PRESTIGE product, and thanks to its twenty-years of experience, is able to answer to the markets needs for Retail Marketing, Digital Signage or Branch Marketing.