In a fast paced, technology based society, it is important that children are given opportunities to explore and use a range of technology, programs and skills. From coding to word processing, children work practically, independently and collaboratively. Children develop an awareness of e-safety and how to stay safe on the internet.


text:
package org.s1.script.pages;

import org.s1.S1SystemError;
import org.s1.cache.Cache;
import org.s1.cluster.Session;
import org.s1.misc.Closure;
import org.s1.misc.FileUtils;
import org.s1.objects.Objects;
import org.s1.options.Options;
import org.s1.script.Context;
import org.s1.script.S1ScriptEngine;
import org.s1.script.errors.ScriptException;
import org.s1.script.function.ScriptFunction;
import org.s1.script.function.URLFunctionSet;
import org.s1.user.UserBean;
import org.s1.user.Users;
import org.s1.weboperation.MapWebOperation;
import org.s1.weboperation.WebOperation;
import org.slf4j.Logger;
import org.slf4j.LoggerFactory;

import javax.servlet.*;
import javax.servlet.http.HttpServletRequest;
import javax.servlet.http.HttpServletResponse;
import java.io.File;
import java.io.IOException;
import java.nio.charset.Charset;
import java.util.Enumeration;
import java.util.Map;
import java.util.UUID;

/**
 * Script pages filter
 */
public class S1ScriptFilter implements Filter{

    private static final Logger LOG = LoggerFactory.getLogger(S1ScriptFilter.class);

    private S1ScriptEngine scriptEngine;
    private boolean debug;
    private Cache pageCache;

    protected String getPage(String path){
        //if(path.endsWith(".html"))
        //    return path;
        if(path.equals("/")){
            return "/index.html";
        }else{
            return path+".html";
        }
    }

    @Override
    public void init(FilterConfig filterConfig) throws ServletException {
        scriptEngine = new S1ScriptEngine("pages.scriptEngine");
        debug = Options.getStorage().getSystem(Boolean.class,"pages.debug",false);

        pageCache = new Cache(Options.getStorage().getSystem(Integer.class,"pages.cacheSize",1000));
    }

    @Override
    public void doFilter(ServletRequest req, ServletResponse resp, FilterChain chain) throws IOException, ServletException {
        HttpServletRequest request = (HttpServletRequest)req;
        HttpServletResponse response = (HttpServletResponse)resp;
        String page = request.getRequestURI().substring(request.getContextPath().length());
        if(page.matches(".*/.+\\.\\w+$") || page.matches("^/dispatcher/.*$")){
            chain.doFilter(req, resp);
            return;
        }
        process(request,response);
    }

    @Override
    public void destroy() {

    }

    protected void process(HttpServletRequest req, HttpServletResponse resp) throws ServletException, IOException {
        String id = null;
        try {
            id = WebOperation.getSessionId(req, resp);
            Session.start(id);

            String path = req.getServletContext().getRealPath("/");
            if (path.startsWith("WEB-INF")) {
                resp.setStatus(403);
                return;
            }
            String page = req.getRequestURI().substring(req.getContextPath().length());
            resp.setContentType("text/html");
            resp.setCharacterEncoding("UTF-8");
            String res = "";
            try {
                res = get("", path, page, MapWebOperation.convertRequestToMap(req), Objects.newSOHashMap(), req, resp);
            } catch (Throwable e) {
                LOG.error("Page: " + page + " error", e);
                resp.setStatus(500);
                if(debug)
                    res = "Page: "+page+" error: "+e.getClass().getName()+": "+e.getMessage()+"";
            }
            resp.getOutputStream().write(res.getBytes(Charset.forName("UTF-8")));
        }finally {
            Session.end(id);
        }
    }

    protected String get(String currentPath, final String dir, String file, final Map<String,Object> params, Map<String,Object> local,
                         final HttpServletRequest req, final HttpServletResponse resp) throws Exception{
        file = getPage(file);
        String page = "";
        if(file.startsWith("/")){
            //abs
            page=dir+"/"+file;
        }else{
            //rel
            page=currentPath+"/"+file;
        }
        page = page.replaceAll("\\\\","/").replaceAll("/+","/").replace("/",File.separator);

        final String cp = page.substring(0,page.lastIndexOf(File.separator));

        final String url = req.getRequestURL().toString();
        final String context = req.getContextPath();
        final UserBean user = Users.getUser(Session.getSessionBean().getUserId());
        final Map<String,Object> headers = Objects.newHashMap();
        final Map<String,Object> responseHeaders = Objects.newHashMap();

        //final Map<String,String> includePages = Objects.newHashMap();
        //final Map<String,Map<String,Object>> includeParams = Objects.newHashMap();

        Enumeration<String> eh = req.getHeaderNames();
        while(eh.hasMoreElements()){
            String s = eh.nextElement();
            headers.put(s,req.getHeader(s));
        }
        final Map<String,Object> layout = Objects.newHashMap();

        LOG.debug("Rendering page: " + page);
        String text = null;
        if(debug) {
            scriptEngine.invalidateCache(page);
            text = FileUtils.readFileToString(new File(page), "UTF-8");
        } else {
            final String _page = page;
            text = pageCache.get(page, new Closure<String, String>() {
                @Override
                public String call(String input) {
                    try {
                        scriptEngine.invalidateCache(_page);
                        String s = FileUtils.readFileToString(new File(_page), "UTF-8");
                        if (s == null)
                            s = "";
                        return s;
                    } catch (IOException e) {
                        throw S1SystemError.wrap(e);
                    }
                }
            });
        }

        if(Objects.isNullOrEmpty(text)){
            resp.setStatus(404);
            LOG.info("Page not found: "+page);
            return "";
        }
        String port = "";
        if(req.getScheme().equals("http") && req.getServerPort()!=80)
            port = ":"+req.getServerPort();
        else if(req.getScheme().equals("https") && req.getServerPort()!=443)
            port = ":"+req.getServerPort();
        String query = req.getQueryString();
        if(!Objects.isNullOrEmpty(query)) {
            URLFunctionSet url_fs = new URLFunctionSet();
            String arr [] = url_fs.removeParams("url?" + query, Objects.newArrayList("_pjax")).split("\\?", -1);
            query = arr.length>1?arr[1]:"";
        }
        text = scriptEngine.template(page, text, Objects.newSOHashMap(
                "page",Objects.newSOHashMap(
                        "params",params,
                        "headers",headers,
                        "responseHeaders",responseHeaders,
                        "url",url,
                        "method",req.getMethod().toLowerCase(),
                        "query",query,
                        "uri",req.getRequestURI(),
                        "scheme",req.getScheme(),
                        "host",req.getServerName(),
                        "hostname",req.getServerName()+port,
                        "port",req.getServerPort(),
                        "relative",req.getRequestURI().substring(req.getContextPath().length()),
                        "context",context,
                        "debug",debug,
                        "isAnonymous",Session.getSessionBean().getUserId().equals(Session.ANONYMOUS),
                        "user",user,
                        "clientIP",WebOperation.getClientIpAddr(req)
                ),
                "args",local,
                "include",new ScriptFunction(new Context(10000),Objects.newArrayList("path","params")) {
                    @Override
                    public Object call(Context ctx) throws ScriptException {
                        Map<String,Object> l = ctx.get("params");
                        String p = ctx.get(String.class,"path");
                        String id = UUID.randomUUID().toString();
                        //includePages.put(id,p);
                        //includeParams.put(id,l);
                        //return "---"+id+"---";
                        String t = "";
                        try {
                            t = get(cp, dir, p, params, l, req, resp);
                        } catch (Throwable e) {
                            LOG.error("Inner page: " + p + " error", e);
                            if (debug)
                                t = "Inner page: " + p + " error: "
                                        + e.getClass().getName() + ": " + e.getMessage() + "";
                            t = "";
                        }
                        return t;
                    }
                },
                "layout",new ScriptFunction(new Context(10000),Objects.newArrayList("path","params")) {
                    @Override
                    public Object call(Context ctx) throws ScriptException {
                        Map<String,Object> l = ctx.get("params");
                        String p = ctx.get(String.class,"path");
                        layout.put("page",p);
                        layout.put("params",l);
                        return "";
                    }
                }
        ));

        for(String s:responseHeaders.keySet()){
            resp.setHeader(s,Objects.get(String.class,responseHeaders,s));
        }

        /*for(String id:includePages.keySet()) {
            String p = includePages.get(id);
            Map<String,Object> l = includeParams.get(id);
            String t = "";
            try {
                t = get(cp, dir, p, params, l, req, resp);
            } catch (Throwable e) {
                LOG.error("Inner page: " + p + " error", e);
                if (debug)
                    t = "Inner page: " + p + " error: "
                            + e.getClass().getName() + ": " + e.getMessage() + "";
                t = "";
            }
            text = text.replace("---"+id+"---",t);
        }*/

        if(!layout.isEmpty()){
            String p = Objects.get(layout,"page");
            Map<String,Object> l = Objects.get(layout,"params");
            l.put("layout_content",text);
            try{
                text = get(cp,dir,p,params,l,req,resp);
            }catch (Throwable e){
                if(debug)
                    text = "Layout page: "+p+" error: "+e.getClass().getName()+": "+e.getMessage()+"";
                LOG.error("Layout page: "+p+" error: "+e.getMessage(),e);
            }
        }

        return text;
    }
}

redpajama_set_name: RedPajamaGithub


Which pump should you choose for your job?
Home > Which pump should you choose for your job?
With a wide variety of pumps available, it can be tricky to determine which pump to use for which application. Companies that do not have a large range will often direct you to their standard pump, which will not always yield the most efficient and desirable results, and potentially leave your operation not as efficient as it could be.
Enerpac is the recognised global leader in high pressure hydraulic tools and equipment, with one of the most extensive ranges of pumps available, from hand pumps to PLC-controlled Synchronous Lifting Systems.
Through their global expertise, they have developed a range of pumps that optimises performance and safety under every circumstance.
How many tools or cylinders will I power with the pump?
What 'power' is available at my application?
If more than one cylinder will be used, how accurate do I want to lift, lower, position or press?
"This shows that for each application, you have to carefully decide what will be right for you," Verhoeff said.


The Blue Jackets racked up 40 hits in Game 1 including a hit that forced Bruins' David Krejci to leave the game.
Bruins coach Bruce Cassidy says David Krejci is day-to-day after taking a hit in Game 1 that caused him to leave the game.
Jordan Binnington's strong goaltending is transforming the Blues, and he and Vladimir Tarasenko helped power St. Louis to an early series lead vs.
Vladimir Tarasenko scores two goals and Jordan Binnington saves 27 shots as the Blues take a 1-0 series lead over the Stars.
John Klingberg beats his man and sets up an open Jason Spezza who slaps in a one-timer to tie the game 1-1.
Robbie Fabbri races down the ice and goes through the wickets on Stars goalie Ben Bishop to give the Blues a 1-0 lead.
Charlie Coyle gets a pass from Marcus Johansson and smashes a one-timer to tie the game with less than five minutes remaining in the third period.
Fernando Alonso says that he wasn't able to learn much during testing at Indianapolis because of poor weather conditions and mechanical issues.
Two high-powered offenses will face off as the Sharks and Avalanche clash in Round 2 of the Stanley Cup Playoffs.
Lord Stanley has a story to tell, see which team writes the latest chapter as Round 2 of the Stanley Cup Playoffs begins.
NASCAR America unveils the top five upsets of all-time at Talladega Superspeedway.
AJ Allmendinger and Parker Kligerman explain what separates Talladega from other superspeedways on the NASCAR circuit.
Chris Simms sits down with resident Jets fan of Simms: Unbuttoned, James Kaminsky, to reminisce about the team's bad NFL draft picks.
Assuming that Jeffery Simmons returns healthy, he will be a great longterm pickup for a NFL team.
Greedy Williams is going to be a real pest for all No. 1 receivers and is the top corner in this year's draft class.
Rashan Gary could be a boom if he reaches his full potential, but has a long way to go in order to do so and thus carries a serious risk of busting.
Brian Burns has super-sonic speed coming off the edge and a change-of-pace inside spin move, making him a top-10 prospect in this draft class.
The Cardinals and Giants are keeping everybody guessing ahead of the draft, while Chris Simms preps for his watch party in New York.


text:
HomeSportsLocal & State SportsLake Mills 2020 Football Preview
Lake Mills 2020 Football Preview
August 12, 2020 Zarren Egesdal Local & State Sports, Sports 0
The Lake Mills football team is looking for a comeback 2020 following a hopeful 2019 that wasn't meant to be.
Last fall, the Bulldogs were in the second year of their new offense and had the athletes to compete. Coming off a conference track championship, Lake Mills knew they could run in the open field. Though, Lake Mills couldn't fight off the injury bug, which plagued them from start to finish last season. The Bulldogs finished the season 4-5 and 1-3 in Class 1A District 3.
Now, in the third year running option football, Lake Mills coach Bill Byrnes says expectations are they'll execute at a high level.
https://kiow.com/wp-content/uploads/2020/08/Lake-Mills-FB-Preview-2.mp3
It was tough preparing for this season with the global pandemic. Byrnes wasn't able to hold out-of-season workouts until July.
https://kiow.com/wp-content/uploads/2020/08/Lake-Mills-FB-Preview-1-.mp3
The Bulldogs will return most of their go-to offensive player makers from last season. Casey Hanson and Carson Eaton rushed for over 850 yards, quarterback Bennett Berger will return to lead the offense, and guys like Dalton Thorson and Brady Hanson, who stepped up to fill in injury gaps last season, will bring back experience.
As the legendary Bear Bryant once said, "defense wins championships," the defensive will be looked at in a big way this season. The leader of that defense is returning all-state linebacker Caleb Bacon. Bacon recorded 92 total tackles last season, which was 28th in all classes. He recorded 21.5 tackles for a loss and 7.5 sacks.
Lake Mills will start the season against county rival Forest City. The Indians and Bulldogs haven't played in football since September 4th, 2009. Forest City won that matchup 21-20; they've won the last three meetings.
Using information available, the first recorded meeting took place in 1951, with Forest City winning 13-7. Forest City leads the series 12-3-1, with Lake Mills winning in 1968, 1972, and 1989.
Lake Mills and Forest City are familiar with the 'big game' feel. Just this last school year, the volleyball and baseball conference championships were decided between the schools. In boys basketball, Lake Mills needed to beat Forest City to win at least a share of the title. With the track season not happening this season, the last conference track championship came down to Lake Mills and Forest City.
The Bulldogs and Indians will open the season on August 28th in Lake Mills. The game will be live on KIOW and the KIOW video stream.
Worth County 4-H Receives $2,000 Grant for Community Gardens
Hilda F. Greiman

redpajama_set_name: RedPajamaCommonCrawl


1002 FOSTER AVENUE, LLC is a business entity registered in the state of New York under the legal form of DOMESTIC LIMITED LIABILITY COMPANY. It can be found in the register by the DOS ID 2043140. The company was established and set into the register at 27th June 1996 and its current status is ACTIVE. Company´s jurisdiction is in the state of NEW YORK in county KINGS. Process address of this entity is at C/O WILAMOWSKY, BROOKLYN, 11230, NEW YORK.
LIGHTNING PAVING & SEALCOATING CORP.
TULLIO STUDIO OF CROSSGATES, INC.
CROSS PARK OF NEWARK INC.
PRINCETON VALET & LINEN SERVICE, L.L.C.
METIN KOLUKSUZ, M. D., P. C.
TOWN TOPPERS SOCIAL CLUB, INC.
ACRO PLUMBING & HEATING, INC.
THE BLUE KNIGHTS MOTORCYCLE CLUB SUFFOLK, INC.
ARIA EMPLOYEE BENEFIT SERVICES INC.
DL RESTORATION & BUILDERS II CORP.
KWIK KOLD REFRIGERATION OF SUFFOLK, INC.
FORDHAM INTERNATIONAL LAW JOURNAL ALUMNI ASSOCIATION, INC.
11 ACHDUS SUMMER HOMES, INC.
M.D. NEWS LONG ISLAND, L.L.C.
BEAUTIFUL RIVER LANDSCAPE DESIGN, INC.


Her body was found late last week.
The reality TV star's demise shows the barriers that black Americans face when trying to seek help for mental illnesses.
She toured with her show about Asian-American women and depression for seven years.
Does Bollywood Drop the Ball on Mental Health?
The Aerogram makes a pretty compelling case.
Native youth are more than three times more likely to commit suicide than any other group.
He also sheds light on the broader issue of black men to cope with depression and anxiety.
Brandon Marshall had a point to make.
A new report reveals that immigration reform could save hundreds of thousands of children from suffering physical and mental health strains.
Asian American women ages 65 and older had a higher suicide rate — 6.5 per 100,000 — than any other racial or ethnic group.
Colorlines readers responds to the White House's proposals to prevent gun violence.
There's scant evidence of a link between mental illness and violence. Still, advocates say, the mental health system desperately needs more resources and attention.
The State of Texas is poised to outsource management of a public psychiatric hospital to a company that's made its billions in the business of private criminal and civil immigration lockup.
So July, and National Minority Mental Health Awareness Month, are over. What are you doing to take care of yourself today?
July is National Minority Mental Health Awareness Month.
People dedicated to racial justice are often so focused on strengthening our communities, we fail to remain healthy ourselves. Monica Novoa speaks with organizers who are helping the movement mind its own mental health.
Donna Hernández gives us her personal story of how running changed the way she dealt with stress, and approached social justice work.
From the classroom to the clinician's office, there's a long and troubling relationship between racism and the mental health field.


Matt it will be.interesting to see how the kits compare. I have done a bit more work added some weld seams and road wheel arms. I have been consulting my limited sources on the IS2 and most of the combat pictures show them without fuel drums, especially the Berlin pictures. I was thinking about doing a Berlin tank. The question is to drum or not to drum. I am also tempted to use Polish markings, would it be a breach of rules to do a Russian allie?
I'll have to ask again... are what-if builds allowed as long as they fulfill the weight and origin criteria?
The pictures I have seen are by no means conclusive and covers every JS2. You have done a great job on your fuel tanks and I just started mine. I also saw some JS2s with all the fenders trashed. They may have dropped them to avoid getting the all shot up.
Do what's best for you. If you don't have conclusive proof its up to you. It's looking good so far.
I said in the campaign proposal that "Entries must have at least been proposed by the country's military. No what ifs allowed."
Curses! So 414 didn't have fuel drums in Berlin. It had extra log protection / ditching beams. But wait a second, could that be tank 413?! ... A completely different fish to 414?!
Looks like 414. So yours would be a week before Berlin.
Thanks for the clarification,Timothy! Must have overseen that.
I'll have to see if I'll be joining then as I had a specific combination in mind that I'd like to build soon.
The Friulmodel tracks are complete. I've included the naff Zvezda tracks in the photo for comparison. They really don't compare.
Next up, primer, then paint.
Hmmm. Looks like I've put the tracks on the wrong way round.
I am submitting my JS-3 Initial production seen at the Berlin Victory Parade.
Some great builds already. I have just signed up. I am doing the Dragon 1/35 IS-2.
Slow progress on my IS 2. I joined the upper hull I will have to figure an a marking option before I go much further.
I think about signing in here with an Azerbaijan T-72 AV. "Normal" T-72 have 41.500 kg combat weight but I guess all the ERA blocks fixed at these AV tanks will raise the combat weight over those magic 42.000 kilo of this campaign? Until now I wasn´t able to find out the real weight of this specific type.
Second point is I have no clue if the Soviet Union / Russia fielded this specific type or not.
This is my first campaign entry at all and I chose a T-72 AV. I´m not sure at this moment at which colors I will finish him but I have Azerbaidjan or Kenya in my mind.
I did shaved off the frontal applique armor plate as it won´t be needed for this variant.
Drive sprockets, idler and roadwheels are finished now. According to Tamiya´s construction manual there is now the frontal lower hull plate to glue but I ommitted that because I will use the folded out scraper blade from Chesapeake. But because of some very delicate parts I will do this at a very late stage during my build.
I will be changing the climbing brackets on the turret which are molded solid on the kit. Will be using 0.5mm solid wires to scratch-build the climbing brackets... And stranded copper electrical wires for the towing cables, to replace the kit-supplied towing cables, which are molded in the vinyl-like material.
this is my weekly update: I´ve installed TRUMPETERS single link tracks on the tank. I did read a review report here that these tracks have connector pins for easy assembly... well my set dont have them and I needed to glue everything in place. Will be a bit more difficult to paint it all later. But it looks a lot more better than TAMIYA´s old vinyltracks.
Next weekly update from my side: Sorry but this week there was not much spare time for modelling. I just finished building the tanks hull, closing the holes at the frontal upper armor plate with putty and started to install the ERA-blocks. The frontal blocks are finished now and I have to turn my attention for the side ones.
As I plan to do an Azerbaidjanian vehicle I have to work according to the few fotos I have and the attachment of these ERA-blocks are a bit different to MODELPOINT´s construction plan. I also can see from the photos that these blocks (at least the upper hull ones) have been attached with some distance pieces, not flat onto the tanks armor. Therefore I used my trusted Punch and Die set and made quite a lot spacers to let it look realistic. I´m satisfied with the results until now. What do you think?
@ Thomas: I really like the ERA blocks on your Tamiya T72. Looks great!
I will post an update on my JS2 later this evening. Not much progress, but it is now green at least.
I'll post more photos individually, as soon as I'm back from holiday.


text:
First-year student brings ONE advocacy movement to campus
By Trang Le|March 23, 2018
ONE at Lafayette, a new student group on campus initiated just last week, has plans to hit the ground running in fighting for both international and domestic policy changes. ONE is "a campaigning and advocacy organization of more than nine million people around the world taking action to end extreme poverty and preventable disease, particularly in Africa," according to its website.
The ONE chapter at Lafayette was founded by Ellie Aaberg '21 and is part of a nonpartisan advocacy campaign taking action to influence US policies and also to engage in international philanthropy efforts.
The campaign has a variety of initiatives, among which is ONE Campus, a subsection that reaches out to college students, using their voices to create change.
"When I met Gordon Wong, my friend's cousin and Head of College Engagement of ONE in D.C., he suggested that I bring the idea to Lafayette. I then created a Facebook page and started talking to people about it," Aaberg said.
Aaberg is currently the Campus Leader of ONE at Lafayette and Olivia Barney '21 is the Vice Campus Leader of the group.
"I also have a couple of people that I've talked to who are interested to help. I think it's going get a lot of footing here because it's really young on campus," Aaberg said.
In line with the nonpartisan nature of its parent campaign, ONE at Lafayette plans on recruiting members using a grassroots approach.
"That's how I want to do it. I want to just spread the word out there, getting people fired up about advocacy, getting them to talk to their representative senators to bring about changes," Aaberg said.
Although ONE is still growing and has yet to gain official approval from the student government, Aaberg said she thinks they have a lot of potential.
"That's the next step, going to student council and proposing our club. We have all the resources because ONE Campus is very organized. We only need to call for support from the school and from students," Aaberg said.
According to Aaberg, while ONE Campus offers limited funding, they would supply ONE at Lafayette with all the necessary merchandise like stickers and t-shirts for initial promotion.
"They could also sponsor events that we want to host on campus like for example, a movie night that highlights poverty," Aaberg said.
At every level, ONE organizations look forward to delivering the messages that we are all "one."
"For me, when I hear first heard of ONE and knew what they do, I thought of this idea: We have campuses everywhere all participating in the movement, like a broad world that all connect with each other as one group, sharing one goal," Aaberg said.
ONE at Lafayette is simultaneously working on two campaigns: calling for globalized internet usage and protesting against President Donald Trump's 30 percent cut in the International Aid Budget.
"The core campaign on internet usage is a declaration that we're trying to get a million signatures on. The declaration demands that internet be accessible worldwide, so everyone can access and benefit from it. Internet usage can lead to more transparency with the government policies, encouraging people to use government resources, establish businesses or make use of educational tools," Aaberg said.
"It's just word of mouth right now, but I'm hoping to do a tabling in Farinon," she added.
As for the campain on the International Aid Budget, ONE has been contacting representatives telling them to not support President Trump's decision to cut back on foreign aid, which will be finalized this week.
"From a moral standpoint, International Aid Budget is something the US should be engaged in to work against diseases and poverty internationally," Aaberg said.
"Not only does the work benefit the people that we're aiding, but it also benefits the image of our country: people are so used to the sight of American flags on soldiers instead of, for instance, a medical box or a new school–this is another side of the US that I want people to see," she added.


text:
Surada
British Steam passenger ship
Name Surada
Type: Steam passenger ship
Completed 1920 - R. & W. Hawthorn, Leslie & Co Ltd, Hebburn-on-Tyne
Owner British India Steam Navigation Co Ltd, London
Homeport Glasgow
Date of attack 26 Jan 1944 Nationality: British
Fate Sunk by U-188 (Siegfried Lüdden)
Position 13° 00'N, 55° 15'E - Grid MQ 4565
Complement 103 (0 dead and 103 survivors).
Route Calcutta - Colombo - Aden - Suez
Cargo 5000 tons of general cargo
History Completed in July 1920
At 18.48 hours on 26 Jan 1944 the unescorted Surada (Master Ellis Henderson Brady) was hit by two stern torpedoes from U-188 40 miles east-northeast of Socotra Island. The ship broke in two and sank at 19.06 hours. The U-boat surfaced and asked the survivors about any losses and whether they had any provisions such as water. The master, 86 crewmen, nine gunners and seven passengers were picked up the following day by the British motor merchant Darro and landed at Aden on 29 January.


Names of officials: Front row, seated: Wieger DeJong (Reeve, Stirling Village); Tom Nobles (Reeve, Sidney Township); Jack Robinson (Reeve, Elzevir & Grimsthorpe Townships); Kenneth Wilson (Reeve, Carlow Township); Warden Bruce Davis (Reeve, Bangor, Wicklow & McClure Townships); Wm. Bouma (Clerk-Treasurer & Administrator); Jim Pollock, M.P.P. (Hastings-Peterborough); Harry Danford (Reeve, Rawdon Township); George Beer (Reeve, Thurlow Township). Second row: Joe Best (Reeve, Monteagle Township); Lloyd Churchill (Reeve, Bancroft Village); Rob McLaughlin (Administrator, Hastings Centennial Manor); Ronald Hamilton (Deputy Reeve, Sidney Township); Arnold Burkitt (Reeve, Tudor & Cashel Townships); Deborah Smart (Deputy Treasurer); Dorothy Bowes (Administrative Assistant); Doris Danford (Reeve, Wollaston Township); Nadine Burrows (Administrator, Hastings Manor); Wes Moffatt (Reeve, Limerick Township); Kenneth Shannon (Reeve, Tyendinaga Township); Tom Deline (Reeve, Madoc Village); James R. Duffin (Personnel/Purchasing/Deputy Clerk). Third row: Basil Cox (Reeve, Faraday Township); Andre Philpot (Reeve, Marmora Village); Hugh Laundry (Reeve, Herschel Township); Niall Carney (Director, Planning); Larry Hartin (Reeve, Hungerford Township); Martin West (Reeve, Dungannon Township); Joe McGrath (Deputy Reeve, Marmora & Lake Townships); Sam Knapp (Reeve, Deseronto Town); Earl Hewison (Reeve, Frankford Village); Gerry Masterson (Deputy Reeve, Thurlow Township); Neil Williamson (Director, Economic Development). Fourth row: Garry Jewell (County Engineer); Harold Harris (Reeve, Madoc Township); Arthur McMunn (Reeve, Mayo Township); Tom White (Deputy Reeve, Hungerford Township); Morley Marquette (Deputy Reeve, Bangor, Wicklow & McClure Townships); Owen Ketcheson (Reeve, Huntingdon Township); George Nelson (Reeve, Deloro Village); Tim Enright (Deputy Reeve, Tyendinaga Township); Eric Fry (Director, Social Services). Absent: Graham Bell (Reeve, Marmora & Lake Townships); John Clemens (Reeve, Tweed Village).


The end of June saw the end of the 2014 school year for Canford School in Dorset, which in turn meant their annual Speech Day and Graduation Ball.
Earlier this year we were approached by Canford School and asked if we could provide them with an overall event management service for the event which included items such as marquee, sound and lighting installations, entertainment booking, bar installation, photo booth hire, dodgems entertainment, 'luxury loo's' and on site event management.
The speech day saw 1,800 students, parents, teachers and staff attending to hear speeches from the Headmaster Ben Vessey, the Head Boy and Girl, and the guest of honour Lord Dobbs of Wylye. There was then a quick turnaround of the marquee venue to become an evening bash for 500 guests for their graduation dinner, drinks and ball.
It was a fantastic day all round and a great opportunity for the parents to celebrate alongside their graduating children. During the evening there was some incredible entertainment including; stilt walkers, fire breathers, a magician, a juggler, bumper cars and the ever popular 'The Brightside Band', followed by Lee Evans DJ'ing the night away.
"This is the first time that Canford School have worked with Seventa and our Summer Ball was the best one ever. Seventa are incredibly professional, innovative and exceptionally easy to work with. Nothing is too much trouble and we would not hesitate in using them again for future events. Thank you for making our event such a memorable one." Executive Assistant to the Bursar of Canford School.
Take a look at a few of the pictures we took throughout the day and evening..
We are opening a pop-up summer venue, on Bournemouth Beach!


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Fortnite: Leaked Week 8 Hunting Party screen features the A.I.M skin and a mysterious hologram
by Ross Deason
The Week 8 Hunting Party loading screen for Fortnite Battle Royale has been leaked data miners following the release of the v6.30 patch.
The latest update was implemented on November 14, introducing the all-new Mounted Turret trap and the Food Fight LTM and much more.
There have also been a number of cosmetic leaks, including some cool new skins, gliders, pickaxes and emotes that are expected to be added to the game in the coming weeks.
The latest leak, though, is related to the eighth week of the Hunting Party challenge as the loading screen containing the hint to complete it has now been revealed.
You can check out the loading screen in the image below. As you can see, the A.I.M character is up to something suspicious! He's looking at a hologram of what appears to be part of the Fortnite map, but we're not sure what else to make of it.
The Hunting Party is an ongoing bonus challenge that runs throughout Season 6. Players that complete all of the weeks earn a mystery skin, much like Season 4's Blockbuster challenge and Season 5's Road Trip challenge.
This season that mystery skin turned out to be the A.I.M outfit and completing a total of seven weeks was enough to unlock it, so Week 8 is unlikely to be as important to some fans.
Read More: Leaked Fortnite skins and cosmetics found in the v6.30 patch files
You'll still earn a reward (probably a secret Banner) for completing this week's challenge, though, so it's still worth doing even if you've unlocked the A.I.M skin.
In previous seasons, players were asked to find a secret Battle Star somewhere on the map each week, but Banners were introduced at the end of Season 5 and have alternated with the Battle Star throughout Season 6.
Samsung shut down links to leaked Fortnite Galaxy Unpacked skins
Mongraal and Benjyfishy call for traps to be removed from Fortnite


Windows Server Failover Clustering (WSFC) uses a majority of votes to establish a quorum for determining cluster membership. Votes are assigned to nodes in the cluster or to a witness that is either a disk or a file share witness. You can use the Configure Cluster Quorum Wizard to configure the clusters quorum model. When you configure a Node Majority, Node and Disk Majority, or Node and File Share Majority quorum model, all nodes in the cluster are each assigned one vote. WSFC does not let you select the cluster nodes that vote for determining quorum.
After you apply this hotfix, you can configure a cluster node that does not have quorum votes.
After you apply the following hotfix, you can select which nodes vote. This functionality improves multi-site clusters. For example, you may want one site to have more votes than other sites in a disaster recovery. Without the following hotfix, you have to plan the numbers physical servers that are deployed to distribute the number of votes that you want for each site.
By default, all nodes in the cluster have one vote. After you apply the following hotfix, administrators can change the vote functionality in the quorum model by configuring a node to have 0 votes.
A new NodeWeight property is added to the MSCluster_Node WMI class to let you manage node weights by using WMI.
The PQ switch can be used to enforce the cluster owner and to maintain consistency in the Cluster database.
For example, you have a partitioned 2-node cluster in which NodeA has one vote and NodeB has zero votes. By default, NodeB cannot reach quorum and cannot start the cluster. However, the Cluster database may be updated when the ForceQuorum switch is used to start NodeB even if it does not have quorum. Therefore, NodeB has a newer Cluster database, and NodeB can prevents NodeA from starting and from incorrectly overwriting the updated Cluster database by using its one vote to reach quorum. The PQ switch can be used to prevent NodeA from reaching quorum. Therefore, NodeA waits until it can communicate with the existing cluster and until it can join the existing cluster that has NodeB to obtain the updated Cluster database and to maintain consistency.
The PQ switch performs the opposite action of the ForceQuorum switch. The ForceQuorum switch allows the Cluster service to form a cluster even if it has not received a majority of votes. The PQ switch does not allow the Cluster service to form a cluster even if it has received a majority of votes.
Additionally, the Failover Cluster feature must be installed.
You must stop the Cluster service before you install this hotfix package to avoid the computer from automatically restarting.


In China, two versions of PlayerUnknown's Battlegrounds were released for Android and iOS devices. Dubbed as 'Exhilarating Battlefield' and 'PUBG Army Attack', both of the versions are unique but both of them are free-to-play.
For Android users, you just simply need to download 'TapTap App Store' and simply search for 'PUBG'. PUBG Army Attack is not similar to original PUBG available for PCs and Xbox One. It has its own small twists but Exhilarating Battlefield is an almost identical clone of the original game with some changes required for the mobile version.
As for iPhone owners, you need to follow a few simple steps because you will need a fake account to download the game – none of these steps are not difficult to begin with but we will still guide you nonetheless.
First of all, you need to sign out your original account from iTunes. Once done, you need to create a new account using a different email address. When it comes to a Gmail account, you can simply add '+' after your name e.g. 'yourname+123@mail.com'.
After successfully signing in, you need to enter a fake address, select China as your country, and select 'None' for your payment method.
Now that you are in your new country's store, you should be able to download anything from the App Store which is free. With logged-in, search for the games mentioned above and you should be able to download and install them.
Another important thing that you need to keep in mind is that you will need to create a QQ account which will take just a few moments. With everything set and out of the way, you should be able to experience the Battle Royale on your mobile phone devices.
This is all we have in our guide to installing PlayerUnknown's Battlegrounds on iOS and Android devices. If there is anything else that you would like to add, let us know in the comments section below!


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Prêmio Brasil Paraolímpico foi um prêmio dado de 2008 a 2010 a atletas paralímpicos brasileiros.

O prêmio foi uma iniciativa do Instituto Superar, uma ONG que dá suporte a atletas paralímpicos.

Em 2011, ele passou a se chamar Prêmio Brasil Paralímpico.

Até 2012, ele era o único a homenagear atletas paraolímpicos brasileiros.

Edições

Ver também
 Prêmio Superar

Ligações externas

Prêmio Brasil Paraolímpico

redpajama_set_name: RedPajamaWikipedia


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Tixr - Nightculture Dallas
NightCulture Inc. "Concerts that Change Your Life," is a premier producer of live concerts and events. NightCulture operates in the following markets: Houston, TX, Austin, TX, Dallas, TX, San Antonio, TX. NightCulture was the first Electronic Music oriented company to trade in the public markets.
NightCulture Inc. produces two major music festivals. Something Wicked Halloween Music Festival, which drew over 40,000 fans 2014 in Houston, TX. & Something Wonderful in Dallas, TX making its debut in 2015.
Stereo Live, LLC, a wholly-owned subsidiary of NightCulture, operates Stereo Live, a 25,000 square foot music and live events venue located on 2 1/2 acres of land at 6400 Richmond Avenue in Houston, Texas.
Nightculture Dallas


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Student life in Wageningen
Studying at Wageningen University & Research means studying at a campus surrounded by beautiful nature. You can find excellent facilities on campus. For example, a sports centre, supermarket and several restaurants. But also the international and vibrant city offers plenty entertainment.
International community
Because Wageningen University & Research is a world known a lot of international students come to the university. Almost half of the 5500 students who study for a master's degree is foreigner! This leads to a large international community in Wageningen.
There are more than 20 international associations you can join. One of them is ISOW, the international student organisation. They offer courses, events, and excursions. Or IxESN, the Erasmus Student Network. Who have a buddy programme, excursions, festivities and more.
Would you like to know more about studying in Wageningen and student life? Check out the possibilities to get in contact or visit the university.
Facilities on campus
The campus of Wageningen University & Research measures 70.000m2 and is chosen as most sustainable university of the Netherlands 2017. It is home to students, teachers, researchers and staff from over 103 different countries.
When I visited the campus, it was everything that I could have wished for. The campus breathes life sciences.
Julia, MSc student Plant Science from Delaware
There are various places where you can meet fellow students for drinks, coffee or lunch. Such as student cafe 'The Spot', 'Grand Cafe' or the 'Restaurant of the Future'. Looking for a more active meet up? In 'Sports Centre de Bongerd' you can swim, play tennis, basketball or try one of the many other sports.
- Unfortunately, your cookie settings do not allow videos to be displayed. - check your settings
Wageningen City
Wageningen is a small city with almost 40.000 inhabitants from over 160 different countries and is centrally located in the Netherlands. Amsterdam, Rotterdam and The Hague are only a one-hour train ride away. The campus of Wageningen University & Research is within cycling distance.
The city is surrounded by beautiful green nature. You can relax on the riverbanks of the Rhine river, wander through the forest or hang out in the city centre. Here you can find historic and modern buildings, high-rise student flats, works of art and botanical gardens that all add to the diversity of Wageningen.
Questions about studying in Wageningen? Study Information Office
International Students Blog
Wageningen University & Research
Follow Wageningen University & Research on
 Follow us on facebook
 Follow us on Instagram
 Follow us on Twitter
 Follow us on YouTube
 Follow us on LinkedIn
Apply for a bachelor's
Apply for a master's
Living in Wageningen
INREF
Wageningen Campus
Sports Centre de Bongerd
Future bachelor's students
Future master's students
International students and staff
nl|Startpagina


Miranda Shehu-Xhilaga (Albania) | Galaktika Poetike "ATUNIS"
Miranda Xhilaga is a physician (Tirana University), a scientist (PhD, Monash University) and an Adjunct Associate Professor (Deakin University), living in Melbourne, Australia, since 1995. She has a passion for writing and translating poetry form Albanian in English and vice versa and is a strong believer that translation, as an art between tongues, has the capacity to raise awareness about another culture, its people, their perception of life and beauty. She is the author of (This Pain is Mine), a collection of original poems published in Albanian (Albas Publishing, 2019) and translator of Bantam, an anthology of Albanian verse, published by Austin Macauley Publishers, London. Her original and translated poetry has appeared in many periodicals such as Illz and dedicated on line literary websites such as Atunis and FEKT (Fund for Cultural education and Heritage).
Knitting a pair of woollen gloves?
that sings and often stays a while?
And half of an orange.
You want to stay now and go later.
Stay a while and then go.
You want to go and perhaps come back.
The pained, from pain…and it just goes on.
People don't sleep for different reasons.


text:
China fines infant formula companies for price fixing
Six milk powder companies fined for price fixing in China set restrictions on minimum prices and used a variety of methods to "disrupt market order" and restrict competition, China's top economic planning body has said.
Reuters 07 August 2013 • 06:27 am
Chinese commercial law enforcement personnel inspect milk powder products at a supermarket in Lianyungang Credit: Photo: Reuters
In a statement, the National Development and Reform Commission said the companies fined had proposed modifying their sales policies and training their staff better.
The NDRC handed down a total of $110 million in fines to six companies following an investigation into price fixing and anti-competitive practices by foreign baby formula makers.
The six were Mead Johnson Nutrition Co, Danone, New Zealand dairy giant Fonterra, Abbott Laboratories, Dutch dairy cooperative FrieslandCampina and Hong Kong-listed Biostime International Holdings.
Biostime was fined 6 per cent of its annual sales because its violations were serious, the official Xinhuha news agency reported separately, citing an unidentified NDRC official.
Fonterra, the world's largest dairy exporter, has come under fire from the New Zealand government, farmers and financial regulators for its handling of a food contamination scare that has triggered product recalls and spooked parents from China to Saudi Arabia.


hands are steady figures between lights. one light has a cover, one is a naked bulb. there is a doorway with the door shut somewhere in this distance. the color of the eyeshadow is purple. the color of the curtain is green. these both conceal what is seeing or allowing to be seen. marvelous the way steel straightens and bends. the rain does the same without being straight or bending at all. hands are the counting figures, the hurried people in a hurricane of blood. veins make waves in microscopic corners. look how all surfaces glow with light flow.


When left untreated, malaria can lead to anemia, which can cause developmental delays in children. Researchers evaluated a three-pronged malaria intervention consisting of antimalarial drugs, insecticide-treated bed nets, and education on preventing the infection for children in Mali. This approach, administered in schools, saw a 95 percent drop in malaria infections and a 44 percent lower risk of anemia, compared to bed nets alone. Students who received this intervention also had an improved attention span, indicating the potential for better educational outcomes.


Revised proposals for the future of council car parks in Monmouthshire are to be presented to the council's Economy and Development Committee on 14th July.
The proposals and the accompanying report can be read here. The proposals include the introduction of free parking after 4pm in Abergavenny, free parking options for Chepstow and greater flexibility in payment methods – as well as the introduction of short and long stay parking rates.
The Economy and Development Select committee debated a report on the future management of car parking provided by Monmouthshire County Council in February. Although members supported some of the proposals, they decided to ask area committees and other groups for further feedback. This work has been done and, subject to any further revisions and recommendations that the select committee members may wish to make, the proposals will then move on to Cabinet for final consideration and decision.
"But it is with a heavy heart that charging Blue Badge holders is also being proposed. This has become more common place and we are also proposing to provide extra time for blue badge holders so, for example, payment for a two hour ticket will actually offer the blue badge holder three hours parking. There are 30 recommendations in total so these are just the 'headlines'. We recognise that car parking is an emotive subject and we cannot satisfy all demands. But we have listened to feedback and have tried to restructure the service to meet needs in individual towns rather than a 'one size fits all' approach.


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Infosaurs- Zayn Malik sends One Direction fans into frenzy with ultra rare throwback after Liam spat
Zayn Malik sends One Direction fans into frenzy with ultra rare throwback after Liam spat
Zayn Malik has sent One Direction fans into overdrive after he shared an ultra rare throwback to his time in the chart-topping band.
The shock reference came days after Liam Payne made some choice words about Zayn, who famously quit the band in 2016 saying he wanted to 'live a normal life.'
Speaking about his former bandmate last week, Liam said he still had 'many reasons to dislike' the Bradford-born star.
After Liam stunned 1D fans with the swipe, it was Zayn's turn to stir the pot as he took to Instagram with a super sweet video of him singing one of his old tunes.
Sharing a clip of him singing the band's You & I, the baby-faced father-of-one belts out the lyrics wearing a hair band.
His beautiful voice is a thing to behold and fans couldn't get enough of the trip down memory lane.
One posted: "Punch me in the face It's like a dream to see you singing 1D song."
While another said: "This slightly makes up for the Liam interview, my hope has been slightly restored."
Liam didn't hold back in his interview with YouTuber Logan Paul.
"There's many reasons why I dislike Zayn and there's many reasons why I'll always, always be on his side," the star explained.
"You can always look at the man for where he is and say, 'Oh yeah, whatever, that guy's ad***'. But at the end of the day, once you're understanding what he's been through to get to that point and also whether or not he wanted to be there."
Zayn had a very bitter break-up with his baby mama Gigi Hadid after her mother Yolanda accused him of pushing her.
The singer denied striking the Dutch mother-of-three but did admit 'harsh words' were exchanged.
Referring to the star's private life, Liam said: "Listen, I don't agree with any of his actions. I can't commend some of the things that he's done. I can't be on his side for that."
Cheryl's ex concluded the interview saying that he'd reached out to his former bandmate, but so far, the answer came there none.
"What I can say is I understand and your only hope is that at some point in their life, the person at the other end of the phone wants to receive the help that you're willing to give them," he mused.
One Direction shot to fame after meeting on the X Factor in 2010.
However after six years of Beatles-esque success, Zayn quit the band, saying he wanted to be a "normal 22-year-old who is able to relax and have some private time out of the spotlight."
His decision was said to have come as a huge shock to the group, with Liam stating it was the 'worst time' for the band.
However he said at the time he was "super sure us and Zayn will always remain the closest friends."
But later that year, the Whole New World star seemed to put paid to the suggestion, telling Fader magazine the band's music was "generic as f***".
Infosaurs- Interview with Gurleen Kaur, Talking about her upcoming music album
Infosaurs- The Family Man actress Shreya Dhanwanthary takes the internet by storm with her bikini pictures; Fans cant stop gushing over her


Beautiful Decoration De Terrasse Exterieur #12 - Deco Salon Peinture was posted in June 24, 2018 at 7:30 pm. If you wish to utilize this picture as your PC wallpaper, you should tap the download link at the bottom or you may just right click on the picture at the top , then pick "Save Image As" to save the Beautiful Decoration De Terrasse Exterieur #12 - Deco Salon Peinture or by pick the "Set Desktop Background As" choice if your internet browser has this capability. If you could not bring the the most beautiful photo you are awaiting for, you should go for "Search Column" at top right or browse more picture backgrounds whichever you like. This picture has the file size is 33kB and the dimension of 714x576. Beautiful Decoration De Terrasse Exterieur #12 - Deco Salon Peinture has been viewed by 19 users and it is an image from Decoration De Terrasse Exterieur.


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Q: Target class [UsersController] does not exist I am trying to load up a view, as simple as that. I don't know where to go I using composer dump-autoload that it was an issue with loading the controller however it didn't help.
The pictures show the project filesRoutes file
Controller
View
Error
I'm hoping to get some help!

A: If you are using laravel 8 you should pass controllers in routes in new way. This syntax which you try is the old one. Check this..
use App\Http\Controllers\UserController;

Route::get('/users', [UserController::class, 'index']);

Also you should follow convention and name your controllers in singluar form. user not users. Let me know if it helped.

redpajama_set_name: RedPajamaStackExchange


text:
package spider.play;

/**
 * Action to moves a full block from one column to another
 * in a given Position.
 */
public class MoveBlock extends Move
{
  public MoveBlock(int from, int to)
  {
    super(from, to);
  }

  public Position apply(Position p)
  {
    //TODO: implement block move
    return p.moveBlock(from, to);
  }

  public String toString()
  {
    return "move(" + from + "," + to + ")";
  }
}


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The World in a Sea Shell is the third album by Strawberry Alarm Clock, released in November 1968 on the Uni label. The album was not a chart success, and was the final LP to include the classic Strawberry Alarm Clock lineup.

Background
When the band's second album, Wake Up...It's Tomorrow, failed to recapture the huge success of 1967's Incense and Peppermints, the band's management decided to exert more control over the recordings for the third album. To this end, they pressured the band to record several compositions written by outsiders, including Carole King and "Incense and Peppermints" lyricists John Carter and Tim Gilbert. The band members bristled at this situation, but reluctantly agreed to it in the end. Thus, five of the album's 12 songs (including most of side 1 of the vinyl LP) were non-SAC songs.

The new direction did not pay off commercially for the band. Many of the tracks on The World in a Sea Shell featured lush orchestration and a gentle, escapist feel that stood in stark contrast to the adventurous psychedelia of the band's past work. This sudden change in direction, seen as a gross miscalculation on their managers' part by the band members, helped seal Strawberry Alarm Clock's fate. This frustrated the band, as their own compositions for this album included some adventurous moments and sound collages that fans might have expected and that weren't too far removed from the style of the previous albums.

Track listing

Side 1

 "Sea Shell" (John Carter, Tim Gilbert)
 "Blues for a Young Girl Gone" (Carole King, Toni Stern)
 "An Angry Young Man" (Bob Stone)
 "A Million Smiles Away" (Lee Freeman, Ed King)
 "Home Sweet Home" (John Carter, Tim Gilbert)
 "Lady of the Lake" (Carole King, Toni Stern)

Side 2

 "Barefoot in Baltimore" (Roy Freeman, Ed King, Mark Weitz)
 "Wooden Woman" (Lee Freeman)
 "Heated Love" (George Bunnell, Randy Seol)
 "Love Me Again" (Lee Freeman, Ed King)
 "Eulogy" (George Bunnell, Roy Freeman, Randy Seol)
 "Shallow Impressions" (Mark Weitz)

Japanese CD bonus track

 "Barefoot in Baltimore" (single version)

Singles from the album
Two singles were released, "Sea Shell" (which didn't chart in the US; No. 88 in Canada) and "Barefoot in Baltimore" (which reached No. 67 in the US charts during the summer of 1968, and No. 45 in Canada). The latter was especially popular on local radio stations in its namesake city of Baltimore, Maryland and was used as a theme song for the city for decades afterwards.

Aftermath
In the wake of the album's release, original members George Bunnell and Randy Seol departed, with the lineup on the band's final album Good Morning Starshine consisting of guitarists Lee Freeman and Ed King augmented by Nightcrawlers singer Jimmy Pitman, and previous drummer Gene Gunnels.

Personnel
George Bunnell – bass guitar, vocals
Randy Seol – drums, keyboards, percussion, vocals
Lee Freeman – rhythm guitar, sitar, vocals
Ed King – guitar, vocals
Mark Weitz – keyboards, vocals

Additional personnel
George Tipton - arrangements
Howard Davis - vocal arrangements
Technical
Paul Buff - engineer
Don Weller - cover illustration

References

1968 albums
Strawberry Alarm Clock albums
Uni Records albums
Albums arranged by George Tipton


NetCracker Technology announced today that Sri Lanka Telecom (SLT), the leading ICT solutions provider and the National Backbone operator in Sri Lanka, has gone live with upgraded NetCracker Revenue Management, Interconnect and Mediation solutions. The upgraded NetCracker Revenue Management solution will provide Sri Lanka Telecom with a number of unique benefits, including rapidly responding to evolving market conditions. Sri Lanka Telecom will also be able to create a seamless, end-to-end revenue management process and accelerate time-to-market for new services, bundles and agreements.
"Our longstanding partnership with NetCracker validates the comprehensive functionality of its cutting-edge BSS offerings. I believe these Revenue Management, Interconnect and Active Mediation solutions will enable us to personalize customer-centric offerings and improve customer satisfaction. Combining our business expertise of over 150 years and implementing modern systems and processes ensure that our customers are able to harness the full potential of our product portfolio by enabling more value additions," said Dileepa Wijesundera, Group CEO of Sri Lanka Telecom.
"NetCracker's comprehensive product capabilities, outstanding on-time, on-budget delivery and full support throughout the implementation enabled us to create an agile and responsive BSS environment. With modern rating and billing as well as real-time mediation capabilities, we will continue to lead Sri Lanka's communications industry by providing innovative and personalized offerings," said D. W. R. Wijeweera, Chief Information Officer at Sri Lanka Telecom.
"By enabling a faster time-to-market for next-generation offerings and services and allowing us to configure new pricing models on the fly, NetCracker's Revenue Management solution will help us compete aggressively in Sri Lanka's growing communications market. I believe this deployment will enable us to improve the bottom line and develop a stronger customer-centric approach, which will introduce a number of strategic business opportunities in the long run," said Ajantha Seneviratne, Chief Marketing Officer at Sri Lanka Telecom.
By consolidating and upgrading Sri Lanka Telecom's rating, billing, mediation and interconnect solutions into NetCracker's next-generation Revenue Management solution, the Sri Lankan service provider can experience a number of new opportunities. These include the ability to compete more aggressively with other operators; to introduce new pricing, rating and billing configurations with ease; to reduce time-to-market for new services; and to significantly streamline revenue management operations.
As part of the upgrade and to ensure a seamless transition, NetCracker delivered a range of professional services, including data migration to move critical information onto the new NetCracker platform.
"An agile and responsive BSS environment is important for communications service providers around the world to develop leading-edge strategies and long-term revenue streams. We look forward to supporting Sri Lanka Telecom's endeavors in the evolving digital world by providing it the next-generation, integrated solutions it needs," said Loh John Wu, Vice President Asia Pacific at NetCracker.


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All Articles Videos Photos Magazine
Eden Hazard nets winning penalty as Chelsea reach Europa final
Chelsea defeated Eintracht Frankfurt on penalties to reach the Europa League final after the semi-final had finished 1-1. Eden Hazard scored the winning penalty as Kepa Arrizabalaga saved two.
Updated : May 10, 2019, 8:20 am
Premier League: Chelsea clinch top-four spot but feeling the strain, says Sarri
Chelsea sealed a place in the top-four of Premier League 2018-19 after their 3-0 win over Watford on Sunday. Arsenal and Manchester United's draws worked in favour of the Blues.
Updated : May 6, 2019, 10:24 am
Premier League: Inspired Eden Hazard double hands Chelsea 2-0 win over West Ham
Eden Hazard scored a brace to take his goal tally to 19 goals in all competitions this season, equalling his previous best for Chelsea in 2014-15.
Updated : April 9, 2019, 10:53 am
Argentina striker Gonzalo Higuain retires from international football
Gonzalo Higuain made 75 appearances for Argentina, scoring 31 goals. His last appearance was in the 2-1 win over Nigeria in the 2018 World Cup.
Updated : March 29, 2019, 9:01 am
Chelsea's Olivier Giroud seeks France return to boost game time
Olivier Giroud, is hoping to get a starting role with France as he has not started a Premier League game for Chelsea since the club signed Gonzalo Higuain.
Updated : March 21, 2019, 10:42 am
Premier League: Everton sink Chelsea 2-0 to upset their top-four plans
Sixth-placed Chelsea stayed on 57 points after their 2-0 defeat at Everton in a Premier League outing on Sunday.
Lionel Messi back in Argentina squad for first time since 2018 World Cup
Lionel Messi has not played for Argentina since their last-16 exit at the hands of eventual champions France, opting to take a sabbatical after what was a disappointing tournament for the five-time Ballon d'Or winner.
Updated : March 8, 2019, 8:27 am
Premier League: Brendan Rodgers Leicester debut marred by Watford, Chelsea edge Fulham 2-1
Premier League: Brendan Rodgers's first game in charge of Leicester City FC ended in a 2-1 loss to Watford. Chelsea survived Fulham fight to stay in touch with top four.
Updated : March 3, 2019, 10:11 pm
Chelsea must be wary of Fulham after Claudio Ranieri exit, says Maurizio Sarri
Fulham, 19th in the standings, sacked Claudio Ranieri as manager on Thursday following a dismal run of results and appointed Scott Parker as his caretaker replacement. Chelsea manager Maurizio Sarri has warned his players to expect a reaction from relegation-threatened Fulham.
Liverpool and Arsenal register routine wins, Cardiff beat Southampton on emotional day
Premier League: Liverpool beat Bournemouth to go back on top of the table while Arsenal beat Huddersfield Town 2-1 to continue top 4 push. Cardiff City earned dramatic win over Southampton on a day of tributes for Emiliano Sala.
Updated : February 9, 2019, 11:54 pm
Pep Guardiola hails Sergio Aguero's big-game mentality ahead of Manchester City vs Chelsea
Manchester City's Sergio Aguero has scored 14 league goals in 22 matches this season and Pep Guardiola is hoping that he can find the back of the net again on Sunday against Chelsea
Chelsea's Eden Hazard relishing partnership with Gonzalo Higuain
Eden Hazard said he was already enjoying playing alongside Gonzalo Higuain, as the pair combined to score four of the five goals for Chelsea against Huddersfield Town
Updated : February 9, 2019, 5:25 pm
Eden Hazard backs new Chelsea signing Gonzalo Higuain to succeed in Premier League
Chelsea signed Gonzalo Higuain in January and bounced back from a disappointing 4-0 defeat at Bournemouth in midweek with a rampant performance against Town, with both Eden Hazard and Higuain netting two goals each.
La Liga: Lionel Messi inspires Barcelona to salvaging draw against Valencia
La Liga: Barcelona fought back from a 2-0 deficit against Valencia to snatch a 2-2 draw as Lionel Messi scored twice and for the 9th straight game in all competitions.
Updated : February 3, 2019, 9:59 am
Emiliano Sala would be proud of Cardiff's 2-0 win over Bournemouth: Warnock
The Cardiff players held up a T-shirt bearing the image of the missing 28-year-old Emiliano Sala, who never played a game for the club.
Row over Hanuman Chalisa: Will Mamata Banerjee govt protect Ishrat Jahan?
Isro to launch Chandrayaan-2 on July 22 from Sriharikota
Karnataka crisis: Are MLAs defecting or being kidnapped as Congress claims?
India got what it asked for: Harish Salve on Kulbhushan Jadhav case verdict
My Take: Any legislator who defects must be denied a ministerial berth


Justin Bieber and Hailey Baldwin were caught once again in the streets of New York getting up close and personal. This time was different though, instead of their usual make-out sessions and PDA, Hailey was seen crying while Justin was seen bawling. Paparazzi caught up with the "No Brainer" singer yesterday, one day after his emotional park hangs, and asked what the reason was behind his tears.
"This," Bieber says holding up a book for the cameras. "You got good days and you got bad days. It's not real if it doesn't have any bad days." The novel Justin had in his hand was Timothy Keller's, The Meaning of Marriage: Facing the Complexities of Commitment with the Wisdom of God. The book, if not obvious enough, is all about living life as husband and wife under the guidance and prayer of the Lord.
"Justin and Hailey get along great, are on the same page about their faith and what they both want out of their future together," a source told Entertainment Tonight. "It took some time for Justin and Hailey to get back together, but the couple knows it was worth the wait."


La hors classe : pas classe.
Written by B. Le Cun | modified Dec 09 2014.
Associate researcher in the CaRO team head by Alain Bui of the PRiSM Laboratory of the Versailles-St-Quentin University.
Associated researcher in the CARO head by Alain Bui (past team Opale head by Catherine Roucairol).
Exact resolution of Combinatorial Optimization problems in parallel and in sequential.
Energy optimization using the Vehicle2Grid concept.


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Home / AFA Classics / anime / fail2ninja / GKIDS / isao takahata / movies / reviews / reviews movies / Studio Ghibli / Only Yesterday (1991)
Rachael Ward February 24, 2016 AFA Classics, anime, fail2ninja, GKIDS, isao takahata, movies, reviews, reviews movies, Studio Ghibli
Taeko Okajima has lived her whole life in Tokyo, enjoying life of a single woman working in a prestigious company. But even with everything she has going for her, she still feels like something is missing in her life. Eager to get away from the humdrum of the city, Taeko decides to take a trip to the countryside and help her extended family harvest safflowers. But it is during this vacation that Taeko's old memories of her childhood struggles start bubbling to the surface. What is it about this trip that has triggered Taeko's nostalgia and will looking back help her find what she is looking for in her life?
Only Yesterday is the 6th film produced by Studio Ghibli, written and directed by Isao Takohata (which was his second time directing a feature length film for Ghibli after Grave of the Fireflies). The film was originally released in Japan on July 20th 1991. The story is based on a manga of the same name written by Hotaru Okamoto and Yuko Tone. The film is noted for exploring the drama genre and telling a story primarily targeted for adults. Even so it became one of the most highest grossing film in the Japanese market and is still held in high regard among critics and anime fans alike. The English adaptation is notable for casting Daisy Ridley (as 27-year-old Taeko), Dev Patel (Toshio), Alison Fernandez (Young Taeko) and many other notable vocal talents (such as Tara Strong, Laura Bailey, Grey DeLisle, and Ashley Eckstein just to name a few).
For Studio Ghibli's western fans, Only Yesterday was the film everyone had heard about but never had an opportunity to see. There were a few glimpses, such as its original airing on Turner Classic Movies in the original Japanese format. But unlike the other Ghibli films, it had never been dubbed or given a wide release. Part of the reason, I think, was due to the nature of the film in general. There are no supernatural beings, no action sequences, no outlandish ordeal that the films protagonist needs to overcome. It is just the story of a woman, looking back on her life to try and get a better idea on where she is going in life. Ironically, what makes this film so different is what makes it a masterpiece of both animation and filmmaking.
To start with, the animation itself, despite having been release over two decades ago, not only still holds up but some of the best animation that has ever come out of the studio. Much like Grave of the Fireflies, the characters faces were animated to match the performances of the actors, which is normally done the other way around in Japanese animation. Though that may not exactly be the case with the English dub, the translation and transition to matching such detailed animation was completely seamless.
Another stand out of the film's animation aside from the characters themselves are the backgrounds. The countryside of Japan seen through the eyes of the older Taeko is lush and detailed. Taeko's flashbacks to her childhood, however, take a different approach, with brighter lighting, faded colors and the character animation done in the traditional Ghibli style. It was a great contrast between the different sequences and helped to signify when the movie jumped back and forth between the present and past.
I'll admit, when I started to watch Only Yesterday, the frequency of the jumps between Taeko and her younger self, it left me a bit confused on what the focus of the film was going to be. However, as I kept watching, the jumps became more apparent and I found myself enjoying them even more as the film went on.
It's amazing how an animated film like this can take a story of a woman remembering her past while going through her day to day and not only making it a compelling narrative but a visual spectacle. Serving as a testament that animation can breathe new life into the mundane and make it extraordinary. Such as a young girl coming to grips with her womanhood, her reaction to her first crush, and her active imagination on becoming an acting star.
Part of the magic this film has is watching how these memories have affected Taeko later on in life and how they influence her to keep moving forward. I'll admit the more I learned of Taeko's past, the more her journey became my journey. How many of those moments of her childhood that I recall going through myself and how they have affected my growth. By the time the end credits rolled, I found myself walking away with a lot to think about. Not just about the film but about myself.
Which is the mark of not just a great film, but an outstanding film.
While I can understand the initial hesitance to give Only Yesterday an English release, I am overjoyed that GKIDS took the opportunity to finally release it to a western audience. The slower pace and sudden transitions may not appeal to some viewers, but Only Yesterday pulls enough on the heartstrings and provides enough jaw-dropping visuals that make these problems seem like nitpicks. If you love Studio Ghibli and all that it has brought to the world of animation, Only Yesterday is a must see. Give it a watch and you may find yourself coming out of the experience with more than you expected.
For our list of theatre locations for Only Yesterday, check out the list here For more info on the film, check out GKIDS website here.


CEO of AUJEES Company Limited, Mr. Augustine Yaw Gyasi has advice Ghanaian to avoid the patronage of foreign drugs and buy the locally made once known as herbal medicine.
He made this statement at the inauguration AUJEES workers workshop which is seek to help people who are sick to be healed with the help of herbal medicine and also educating their workers.
On the flip side of the inauguration AUJEES company also launched their maiden product "Charcoal powder" that fights poison. He therefore pleaded with stakeholders to come on board in terms of support to make her eligible medicine stronger then before.
Finally Mr. Yaw Gyasi warned his colleagues herbalist who are manufacturing fake drugs in the name of herbal medicine to put a stop to it.


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Home / Blog / 7 Questions With Anna Cossairt
7 Questions With Anna Cossairt
Can you tell us about yourself?
"Hello. My name is Anna Cossairt and I am a library media specialist at Park Elementary in Three Rivers, Michigan. This is my sixth year with the district. My second year in my current position."
Why did you start a career in education?
"I have always wanted to work in education. My mom was a teacher and I wanted to be just like her. I love to play school as a child and ended up with a work study position as a reading tutor. This led me to work at an after-school program with kids who had emotional disabilities. Then I landed a title one aid position and finally to my library position."
If you could have any other job what would it be and why?
"I love my job, but if I could get paid to do anything, I would work from home and be a problem solver. I would have people call or email and I would solve their problems. They charge them a fee."
How are kids different now than 30 years ago?
"I wasn't alive 30 years ago, but I think kids today have different advantages and disadvantages. Kids today may not have the opportunity to be bored, which leads them to expect to be entertained rather than being creative, coming up with fun things to do. On the other hand, children today have access to a lot more information and technology than we've ever had in our lifetimes."
How is teaching different now than 30 years ago?
"From my experience, teaching today is much more differentiated and hands on than it used to be. For example, my mother-in-law isn't a strong reader because she got very little phonics instruction. Whereas if she were in school today, she would have given much more. She would've been given much more support."
What would you tell someone who wants to become a teacher?
"To anyone who is thinking about teaching. There are good days and bad days, but education is the place you want to be. If you want associates for a better future."
What is one thing you would change to help kids learn better?
"If I could change anything in education, I would have much less testing and much more learning by doing rather than just teaching for a test. Thank you."
Tags: 7 Questions


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There are currently 1 Condos for sale in Seascape Condo Ph 10. The average price for Seascape Condo Ph 10 properties is $490,000which is 27% lower than all Condos within a 20 mile radius. The highest priced property in Seascape Condo Ph 10 is $490,000 while the lowest priced Condo is listed at $490,000. Most of the properties available in Seascape Condo Ph 10 are Condos . Compared to last month, the average price of real estate in the area has gone up 100%.


The annual Morningside Nature Center Cane Boil and FiddleFest is a Thanksgiving weekend tradition! This year's event is scheduled for Saturday, November 26, 2016.
Step back in time to a simpler era when friends and neighbors gathered together to tackle a big job and make a festival of it! The annual Morningside Nature Center Cane Boil and FiddleFest is just that: a trip back to the 1870's.
In those days, everyone who could grew sugar cane. Come fall, they'd harvest the stalks, squeeze out the juice, then boil the juice down into a sweet syrup. Grinding and boiling the cane down was a long and hard task but the resulting syrup was often the only source of sugar they had.
Cane boils were more than just a lot of hard work, however. Sharing the labor meant less work for everyone. Consequently, cane boils were also a time to come together. Folks would gather to exchange news, gossip, and celebrate community as they worked.
The annual Morningside Nature Center Cane Boil and FiddleFest is a chance to experience these otherwise forgotten traditions.
Cane is fed into a mule-powered press to extract the juice, which is then boiled for up to six hours during the event. Watch as 60 gallons of juice are boiled down to a mere six gallons of syrup. Then it's your chance to taste it!


Bulova engineers tackled the problem of temperature fluctuation by adding temperature regulation to the Precisionist's circuitry. The circuitry in the watch essentially senses temperature changes and adapts to corresponding changes in the quartz crystal's electric pulses. It's a small adjustment that might seem too miniscule to bother with, but tiny changes in pulse strength at the crystal's... This watch was designed to run on 1.35 volt mecury battery, and since Clinten outlawed mecury batteries, some use the 1.55 volt silver oxide battery. After running for 30 years on the 1.35 V battery, it will surely expadite the total failure of your coil set within a reasonably amount if time.
5/11/2013 · Take Out a Bulova Watch Battery. Bulova, a Swiss watch company, produces Accutron, Wittnauer, Caravelle and Bulova watches. Bulova watches have a "snap back," which means the watch case back snaps onto the watch case.
How can I tell if my Caravelle watch is authentic? Your watch is authentic if it was purchased from an authorized Caravelle retailer. If you're unsure, please email us at service@bulova.com.
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Spring break season is once again upon us. While the lucky few are enjoying week-long sun pilgrimages near the equator, the great majority of Minnesotans are left behind. However, March has been shockingly warm. It's no substitute for Panama, but maybe a weekend trip is all you need to cure your cabin fever. Minneapolis is an obvious option, but there are also hidden gems within reasonable driving distance of Mankato for a weekend getaway. Sioux Falls is a great place to start.
The Washington Pavilion, located in downtown Sioux Falls, is a center for all things good, featuring a theater, a community center, an interactive science museum, and many other entertainment options. March 31 & April 1, the center will host the South Dakota Symphony, April 6 is the Science Center's "First Free Friday", meaning free admission for everyone, and on April 9 is the first of three Shrek the Musical performances. Spectacular Saturdays bring workshops at the pavilion on a wide variety of topics—each workshop only costing $8. Wine tasting, comedy shows, tribute concerts–the Pavilion really has it all. A full event calendar can be found here.
If the weather cooperates, Sioux Falls has a number of public parks; some of the best are listed here.
April 6-14 is Restaurant Week, with many Sioux Falls restaurants offering discounted dishes throughout the week. The city's varied dining landscape includes Indian, Greek, Japanese, Brazilian, Italian, Middle Eastern, Irish and countless more cuisines. Restaurant Week is the ideal opportunity to get a taste of everything Sioux Falls has to offer.
As for somewhere to go after your meal, Sioux Falls has a vibrant nightlife. There's Monk's for the beer lovers, Fat Daddy's for comedy shows, and Phil's Pub for cheap drinks and local talent on weekends (beware: no hard liquor served here). Poppadox is a college bar, and for a chic, upscale bar try Crawford's.
While Sioux Falls has its fair share of traditional entertainment, it has uniquely SF attractions as well. The Sioux Falls Roller Dollz offer some good old roller derby action–girls on roller skates tackling each other while doing laps on a track. Zandbroz is a quirky bookstore meets coffeeshop meets old-fashioned soda fountain. Falls Park is a must-see: a waterfall near the middle of the city from which Sioux Falls derives its name.
As for staying overnight, check TripAdvisor or Priceline for hotel deals, or try camping at a state campground—only $8 a night! Or find a nice CouchSurfer to host you. You already know Midwesterners are notoriously friendly, so ask a local for their favorite hangout and get to know the city of Sioux Falls.


Enterprise and Finance helps the College through innovative thought and leadership, collaboratively promoting the best pursuits of the College, influencing cultural change, and being effective stewards of resources by providing top quality providers. The information listed within the part entitled 'What you'll study' is an outline of the tutorial content material of the programme that may take the form of both core or option modules. Modules are designated as core or choice in accordance with professional body necessities and inner Educational Framework assessment, so could also be topic to vary. Students will likely be required to undertake modules that the University designates as core and may have a alternative of designated option modules. Additionally, possibility modules may be provided topic to assembly minimal pupil numbers.
Our close links with main employers make sure the course remains aware of the need of potential employment sectors. A level in business and finance offers you the chance to access a range of graduate positions around the world – in monetary management, investment banking, promoting, advertising, e-commerce, human assets or venture management.
If you happen to determine to take up the non-compulsory placement 12 months lodging and travel prices may be incurred dependent on location of placement. As placements are paid by the employer at minimal wage plus these costs might be coated by the scholar's wage. During this year you'll pay 10% of regular educational charges to the University. You are provided with a placement tutor, and have entry to the recommendation of the full placement workforce, as well as all College scholar help and providers.
Coventry College is committed to making ready you on your future career and providing you with a competitive edge in the graduate job market. The College's Careers and Employability team present a variety of assist providers to help you plan and prepare to your profession. This animation introduces the learner to the ideas of enterprise finance, monetary management, targets of Monetary administration, function of economic management in an enterprise and its importance.
Jinning began her academic adventure at 24 and joined the University of Sheffield as a PhD candidate. Throughout her PhD study, she was a Teaching Assistant on the Management Faculty of the Sheffield College. Her research was funded by the Chartered Institute of Taxation (CIOT) and the Institute Chartered Accountant of Scotland (ICAS). She was awarded a Doctoral Degree after three and a half years. Previous to the completion of her PhD, she was appointed as a module leader on the Sheffield International School (Kaplan). Jinning set up her private training business after two years. As an entrepreneur, Jinning was engaging with teaching and administration roles. Before Jinning joined the Worcester University Enterprise School, she has been working towards professional qualifications with the Institute Chartered Accountant of England and Wales (ICAEW) and the Chartered Institute of Taxation (CIOT).


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Born near Bafaka Balue in the Ndian Division of Cameroon, Blessed E. Ngoe is the author of Walls to Bridges, a novel, and The Sinking Ship: A Critical Analysis of Multiculturalism in Postcolonial Cameroon, a treatise that critiques Cameroonian literature of the postcolonial era.
The tenth child of school teacher Michael Noto Ngoe and Councilwoman Agatha Nandoa Itoe epouse Ngoe, Blessed Ngoe was born in Kumbe Balue, a village near his hometown of Bafaka Balue in the Rumpi Hills of Southwest Cameroon. Graduating from Government primary School Bafaka Balue in 2002, Blessed received his GCE Ordinary and Advanced Level certificates from Government Bilingual High School Ekondo Titi where he graduated as best student in 2009. He then studied Journalism and Mass Communication at the University of Buea between 2009 and 2012. He also received a Master of Arts from the same university in 2015 before moving to New Mexico State University, USA to receive another M.A. in Communication, minoring in National Security. He currently studies at the University of Colorado, Boulder for a doctoral degree in Communication.
Interests and Career
Blessed has expressed interest in political and environmental discourse, focusing on how places influence and are influenced by human political, economic, and cultural practices. Blessed believes that places are living beings with whom we interact, rather than act upon.
In 2017, Blessed published his treatise on the political life of his country, Cameroon through literary criticism. His novel, Walls to Bridges, was published in 2019 after Blessed went through a profound transformative moment as a foreign student in the United States.
Blessed is also a poet, singer and songwriter. His songs have been recorded by artists like Obase Aboli. He enjoys teaching, writing, and being in nature.
Contact Blessed Ngoe
To contact Blessed, please fill the form below


Philadelphia, PA, October 31, 2011 – Proliferative vitreoretinopathy (PVR), or the formation of scar tissue within the eye, is a serious, sight-threatening complication in patients recovering surgical repair of retinal detachment. A new study conducted by investigators at the Schepens Eye Research Institute, the Department of Ophthalmology at Harvard Medical School, and the Massachusetts Eye and Ear Infirmary in Boston, published in the December issue of The American Journal of Pathology, suggests that a cocktail containing reagents to neutralize a relatively small subset of vitreal growth factors and cytokines may be an effective treatment.
In animal models, platelet-derived growth factor receptor α (PDGFRα) is associated with PVR and strongly promotes experimental PVR. Vitreal growth factors outside of the PDGF family promote an indirect route to activate PDGFRα. Importantly, indirectly activated PDGFRα engages a characteristic set of signaling events and cellular responses that are tightly associated with PVR. This study sought to identify the factors that would induce those events, and develop therapeutic approaches to prevent patients from developing PVR.
Vitreous was obtained from normal rabbits or those in which PVR was either developing or stabilized. Normal vitreous was found to contain substantial levels of growth factors and cytokines, which change quantitatively or qualitatively as PVR develops. A set of nine growth agents was found to be most abundant and therefore most likely to contribute to PVR. Neutralizing a subset of these factors in rabbit vitreous eliminated their ability to induce PVR-relevant signaling and cellular responses. A single dose of neutralizing reagents effectively protected rabbits from developing retinal detachment. "Our in vitro approach to characterize and neutralize vitreal bioactivity accurately predicted the efficacy of an in vivo therapy," notes Dr. Kazlauskas.
To identify growth factors likely to be driving PVR in humans, the investigators quantified the level of growth factors and cytokines from human donors that had either PVR, or a non-PVR retinal condition. Fourteen of the 24 agents quantified were present in large concentrations in PVR vitreous. Neutralizing just 7 of these prevented vitreous-induced activation of PDGFRα. Furthermore, the cocktail also suppressed the contraction of these cells in collagen. Therefore, the same neutralization strategy that prevented PVR in rabbits also prevented human PVR vitreous from inducing PVR-relevant responses. These results strongly suggest that a dose of neutralizing reagents may also protect humans from PVR.
"Although the outlook is encouraging, it would be useful to test the effectiveness of this treatment on alternate models of retinal detachment. It is also worth considering a combinatorial approach to therapy. For example, the antioxidant N-acetylcysteine (NAC) prevents retinal detachment in rabbits by blocking intracellular processes. A combined therapy involving the neutralization approach presented here with NAC treatment would doubly-target PVR at the extracellular and intracellular levels," concludes Dr. Kazlauskas.
The article is "A Novel Strategy to Develop Therapeutic Approaches to Prevent Proliferative Vitreoretinopathy," by Steven Pennock, Marc-Andre Rheaume Shizuo Mukai, and Andrius Kazlauskas (doi: 10.1016/j.ajpath.2011.08.043). It will appear in The American Journal of Pathology, Volume 179, Issue 6 (December 2011) published by Elsevier.
Full text of the article is available to credentialed journalists upon request; contact David Sampson at 215-239-3171 orajpmedia@elsevier.com. Journalists wishing to interview the authors may contact Dr. Andrius Kazlauskas at 617-912-2517 orandrius.kazlauskas@schepens.harvard.edu.
The leading global forum for reporting quality original research on cellular and molecular mechanisms of disease, The American Journal of Pathology is the most highly cited journal in Pathology with an Impact Factor of 5.224 according to Thomson Reuters Journal Citation Reports 2010.