Scientists and engineers have long been interested in synthesizing peptides — chains of amino acids responsible for conducting many functions within cells — to both mimic nature and to perform new activities. A designed peptide, for example, could be a functional drug acting in certain areas in the body without degrading, a difficult task for many peptides.
The results, which could provide a new framework for experiments across materials science and chemistry, were published in Nature Communications on December 7.
Gianneschi is the Jacob and Rosaline Cohn Professor in the department of chemistry in Northwestern's Weinberg College of Arts and Sciences and in the departments of materials science and engineering and of biomedical engineering at Northwestern Engineering.
To create the method, Gianneschi, who is also the associate director of Northwestern's International Institute for Nanotechnology, teamed up with Peter Frazier, an associate professor at Cornell who works in operations research and machine learning, and Michael Burkart, a chemical biologist and expert in enzymology at UC San Diego, to find a better way to make peptides that could generate biomaterials — specifically nanostructures and microstructures that could modify proteins in certain ways. The first step was to find the right peptides that would act as enzymatic substrates for these structures.
"Now we were starting to get selectivity," Gianneschi said. By completing this process several times, they were able to home in on optimal peptides.
"Instead of guessing and looking at millions of peptides, we were able to look at hundreds of peptides and very quickly converge on sequences that behaved in completely new ways," he said. When compared against random mutations or guesswork, the algorithm method was statistically far more successful.


the new development cycle of Manjaro v18.0 "Illyria" got kicked off. Therefore we are again open for new wallpapers and artwork from our community and artists. The wallpapers should match our Maia colours as usual. Be creative and be part of the new wallpapers installed by default on our next release series.
Wallpapers not getting in by default will be packed as optional wallpapers to be installed by the user.
The wallpapers and artwork should have a free license like Creative Commons and created by yourself. We will accept photographs, digital artwork and drawings. You can design it around the user interfaces based on our v18.0-alpha1 ISO medias we will release shortly.
Also have this one in even a higher resolution (4K, 8K).
That one i like too because doesn't have "heaviness" on my eyes. I use to put the same image everywhere (login, lock and as background), so i don't see many transitions … even tho i separate after the background for other activities.
@bogdancovaciu: nice work so far.
Abstract works are also appreciated. Photographs don't have to be re-coloured. They simply should suit our themes in style. Always think as a whole.
If someone however wants to design a whole new theme, this is also possible.
I prepared an Easter-basket containing 30 of my more recent wallpapers, including some exclusive tweaks and mods I made only for this submission.
You can also browse through all of my wallpapers and if you find something you like, feel free to use them.
@muser: as always great work mate!
Once i get more time i will play a bit more.
I've redone the Frozen Lake one without the green tint. It's stored elsewhere because I've left it as PNG rather than compressing with JPG. Reason being if you want to use it as a wallpaper for the distribution you can then compress or resize it as you see fit to meet your own packaging requirements.
I downloaded those with a dog and the other with a cat.
@trashing88, your second could look good a login screen background.


text:
Winnipeg Comedy Showcase returns for its 12th edition
TOPICS:comedythe Park TheatreWinnipeg
By Emelia FournierNovember 24, 2016
The Winnipeg Comedy Showcase (WCS) is one of Winnipeg's most popular comedy events. It started two years ago, when Kevin Mozdzen, who works as a media personnel for the Park Theatre alongside being the founder and artistic director of the ODDBLOCK Festival, contacted local comedian Jared Story to discuss how the Park Theatre could contribute to Winnipeg's comedy scene.
Story began the WCS as a weekend comedy showcase as opposed to the weekday bookings that comedians usually have. He decided to make it a quarterly event that features six of Winnipeg's most talented comedians, both new comers and veterans, delivering their best material. There is no underlying theme or category that performers have to abide by. The only restriction is that the same comedian cannot perform on back-to-back shows, allowing for a wider variety of comics.
The first WCS took place on Jan. 24, 2014 and sold out two weeks in advance. Since then, most subsequent shows have sold out. Story hopes to build on the showcase's success with the upcoming 12th edition, which takes place Dec. 16 at the Park Theatre.
"We may have stumbled across this format, but we must be doing something right," said Story.
The upcoming show features Ashley Burdett, winner of this year's Winnipeg's Funniest Person with a Day Job; BUCKO, a sketch comedy husband-and-wife duo made up of Lauren Cochrane and Aaron Merke; H.U.N.K.S. duo Tim Gray and Matt Nightingale; Chad Anderson; and Kyle Bergstresser.
Burdett has over ten years of improv experience. For six seasons, she performed a weekly improvised soap opera with local improv group Soap Scum Presents, and made her stand-up debut at Dana Smith's Women's Open Mic last year. She draws influences from goofy, honest, silly performers, like Amy Poehler, Bo Burnham, and Kate McKinnon, to name a few. Being a comedian who is able to talk and joke about difficult scenarios has helped Burdett get through some tough times.
"If by talking about some tough stuff for me can help someone else, that makes me really happy. Like, if someone sees me and thinks 'aw, man, yeah! These dating situations and living alone stories make me feel better knowing that someone else is going through them!' that makes me feel really good," said Burdett.
In a similar fashion, BUCKO's Lauren Cochrane finds comedy to be a great medium to connect with others. She draws personal influences from the likes of comedians such as Catherine O'Hara, Maya Rudolph, Molly Shannon, and Lucille Ball.
"[Comedy] appears naturally everywhere if you look for it. It's one of the best way to communicate and tell stories. Humour can disarm people so they are more able to listen. You can slip a lot of life lessons in comedy," said Cochrane.
The 12th Winnipeg Comedy Showcase will take place on Friday, Dec. 16 at the Park Theatre. Tickets are $10 and can be purchased at the Park, Music Trader, and Ticketfly, as well as from any of the comedians on the bill. Doors open at 8 p.m. and the show starts at 9 p.m.
Racing on thin ice
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Winnipeg Zombie Walk cancellation indicates unattainable regulations
Shields alone will not solve the root issue of violence

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Is there a tool, or script, that can convert CSS Width/Height to the width=""/height="" equivalent on elements? I write html emails, and an integral part of the process is converting my CSS inline. I've looked for a while for a way to convert CSS Width/height properties into the actual email tags but to no avail.
If there is a tool that exists that performs this function, if not, is there a recommended way to achieve this goal?
Example:
.table_style     {width: 100%;}
.image_style img {width: 250px; height: 50px;}

the end goal would look as follows:

thank you in advance!

A: There are many tools made for this exact use: "inlining" CSS into the body of HTML emails. It does width, height as well as any other properties you have in your CSS declarations.
Here are a couple:
MailChimp CSS Inliner Tool
Campaign Monitor CSS Inliner

redpajama_set_name: RedPajamaStackExchange


Property Entrepreneurs have only one weekend left to secure their share of £30million in funding, as the entry period for the biggest business prize in real estate is drawing to a close.
There is one week left to enter the inaugural Property Week and Bank of Scotland Corporate Search for Property Entrepreneurs which closes on the 9 June.
The initiative will see three up-and-coming property moguls win up to £10 million each to invest in their business, helping realise their property dreams.
The Bank of Scotland £30 Million Search for Property Entrepreneurs is taking place over three UK territories - Scotland and the North of England; Midlands and East Anglia; South and Wales.
The winner will have demonstrated to Bank of Scotland Corporate that they demonstrate passion and a true entrepreneurial spirit.
After completing an entry form, short listed entrants will pitch their business strategy to a judging panel made up of some of the UK's highest profile entrepreneurs, including Kevin McCabe, Chairman of Sheffield United.
Each group of finalists will then be invited to a prestigious event in their territory.
The winner of each of the three events will then go forward to a national final in December where the overall Bank of Scotland Corporate Property Entrepreneur of the Year will be named.
Nick Robinson, Managing Director of Real Estate, Bank of Scotland Corporate, said: 'This really is the last chance for property entrepreneurs who are yet to enter the Search to do so.
'The response we have had so far has been fantastic and I would urge anyone who is thinking of entering at the last minute to do so immediately.
Bank of Scotland Corporate, Real Estate, is inviting applications from established property firms who meet specific entry criteria.
Applicants will be existing established businesses with a minimum current portfolio value of £5million or completed developments with aggregate gross development value of £10million. The applicants must also be based in the UK and driven by a highly motivated and able management team.


text:
A General Study of Dendroctonus ponderosae Infestation of Pinus ponderosa (Area of General Study: Grizzly Gulch, Helena National Forest)
1973_BrownC_THS_0001230.pdf (9.095Mb)
Brown, Cordell; Superneau, Duane
James Manion; Jean Smith; John Christenson
We discovered after some research that there had not been any comprehensive studies done on the mountain pine beetle, Dendroctonus ponderosae (Hopkins), infesting ponderosa pine, Pinus ponderosa (Laws), though it is mentioned extensively in the literature. The literature is extensive with analytical and statistical data concerning various aspects of the life cycle of D. ponderosae.and the nature of its infestation of P. ponderosa and other members of the genus Pinus. Our study attempts to correlate information found in the literature about this specific infestation problem, with an infestation occurring in the Grizzly Gulch area of the Helena National Forest, 2 miles south of Helena, Montana. We attempted to synthesize a general study on the life cycle of D. ponderosae in its attack on P. ponderosa, and did not stress definite numerical analyses, as we felt the literature adequate in this respect. A work somewhat along the same lines, is the excellent comprehensive study presented as a doctoral thesis by R.W. Reid in 1960 on D. monticolae (=D. ponderosae) in lodgepole pine near Radium, British Columbia. We borrowed extensively from his work and other excellent works done by researchers at the Northern Forest Research Centre at Edmonton, Alberta.We discovered after some research that there had not been any comprehensive studies done on the mountain pine beetle, Dendroctonus ponderosae (Hopkins), infesting ponderosa pine, Pinus ponderosa (Laws), though it is mentioned extensively in the literature. The literature is extensive with analytical and statistical data concerning various aspects of the life cycle of D. ponderosae.and the nature of its infestation of P. ponderosa and other members of the genus Pinus. Our study attempts to correlate information found in the literature about this specific infestation problem, with an infestation occurring in the Grizzly Gulch area of the Helena National Forest, 2 miles south of Helena, Montana. We attempted to synthesize a general study on the life cycle of D. ponderosae in its attack on P. ponderosa, and did not stress definite numerical analyses, as we felt the literature adequate in this respect. A work somewhat along the same lines, is the excellent comprehensive study presented as a doctoral thesis by R.W. Reid in 1960 on D. monticolae (=D. ponderosae) in lodgepole pine near Radium, British Columbia. We borrowed extensively from his work and other excellent works done by researchers at the Northern Forest Research Centre at Edmonton, Alberta.We discovered after some research that there had not been any comprehensive studies done on the mountain pine beetle, Dendroctonus ponderosae (Hopkins), infesting ponderosa pine, Pinus ponderosa (Laws), though it is mentioned extensively in the literature. The literature is extensive with analytical and statistical data concerning various aspects of the life cycle of D. ponderosae.and the nature of its infestation of P. ponderosa and other members of the genus Pinus. Our study attempts to correlate information found in the literature about this specific infestation problem, with an infestation occurring in the Grizzly Gulch area of the Helena National Forest, 2 miles south of Helena, Montana. We attempted to synthesize a general study on the life cycle of D. ponderosae in its attack on P. ponderosa, and did not stress definite numerical analyses, as we felt the literature adequate in this respect. A work somewhat along the same lines, is the excellent comprehensive study presented as a doctoral thesis by R.W. Reid in 1960 on D. monticolae (=D. ponderosae) in lodgepole pine near Radium, British Columbia. We borrowed extensively from his work and other excellent works done by researchers at the Northern Forest Research Centre at Edmonton, Alberta.We discovered after some research that there had not been any comprehensive studies done on the mountain pine beetle, Dendroctonus ponderosae (Hopkins), infesting ponderosa pine, Pinus ponderosa (Laws), though it is mentioned extensively in the literature. The literature is extensive with analytical and statistical data concerning various aspects of the life cycle of D. ponderosae.and the nature of its infestation of P. ponderosa and other members of the genus Pinus. Our study attempts to correlate information found in the literature about this specific infestation problem, with an infestation occurring in the Grizzly Gulch area of the Helena National Forest, 2 miles south of Helena, Montana. We attempted to synthesize a general study on the life cycle of D. ponderosae in its attack on P. ponderosa, and did not stress definite numerical analyses, as we felt the literature adequate in this respect. A work somewhat along the same lines, is the excellent comprehensive study presented as a doctoral thesis by R.W. Reid in 1960 on D. monticolae (=D. ponderosae) in lodgepole pine near Radium, British Columbia. We borrowed extensively from his work and other excellent works done by researchers at the Northern Forest Research Centre at Edmonton, Alberta.We discovered after some research that there had not been any comprehensive studies done on the mountain pine beetle, Dendroctonus ponderosae (Hopkins), infesting ponderosa pine, Pinus ponderosa (Laws), though it is mentioned extensively in the literature. The literature is extensive with analytical and statistical data concerning various aspects of the life cycle of D. ponderosae.and the nature of its infestation of P. ponderosa and other members of the genus Pinus. Our study attempts to correlate information found in the literature about this specific infestation problem, with an infestation occurring in the Grizzly Gulch area of the Helena National Forest, 2 miles south of Helena, Montana. We attempted to synthesize a general study on the life cycle of D. ponderosae in its attack on P. ponderosa, and did not stress definite numerical analyses, as we felt the literature adequate in this respect. A work somewhat along the same lines, is the excellent comprehensive study presented as a doctoral thesis by R.W. Reid in 1960 on D. monticolae (=D. ponderosae) in lodgepole pine near Radium, British Columbia. We borrowed extensively from his work and other excellent works done by researchers at the Northern Forest Research Centre at Edmonton, Alberta.We discovered after some research that there had not been any comprehensive studies done on the mountain pine beetle, Dendroctonus ponderosae (Hopkins), infesting ponderosa pine, Pinus ponderosa (Laws), though it is mentioned extensively in the literature. The literature is extensive with analytical and statistical data concerning various aspects of the life cycle of D. ponderosae.and the nature of its infestation of P. ponderosa and other members of the genus Pinus. Our study attempts to correlate information found in the literature about this specific infestation problem, with an infestation occurring in the Grizzly Gulch area of the Helena National Forest, 2 miles south of Helena, Montana. We attempted to synthesize a general study on the life cycle of D. ponderosae in its attack on P. ponderosa, and did not stress definite numerical analyses, as we felt the literature adequate in this respect. A work somewhat along the same lines, is the excellent comprehensive study presented as a doctoral thesis by R.W. Reid in 1960 on D. monticolae (=D. ponderosae) in lodgepole pine near Radium, British Columbia. We borrowed extensively from his work and other excellent works done by researchers at the Northern Forest Research Centre at Edmonton, Alberta.


A Belfast mum is pleading with Housing Executive officials to find an accessible home for her terminally ill child - following a "hopeless" four year wait.
Fiona Fitzsimons, 24, is devastated not to be able to provide her five year-old life-limited daughter Caoilte with a bedroom.
The North Belfast mum said her little girl had been forced to sleep in a living room without bathing facilities since she was diagnosed with Type 1 spinal muscular atrophy as a newborn.
Fiona said a three bedroom bungalow, which would mean a "bedroom and dignity for Caoilte" and bedrooms for her and a 24-hour carer, would "be like gold".
She said she was speaking about her battle with the Housing Executive for the first time after being devastated when a doctor told her a recent sore on Caoilte's head was caused by poor rinsing of her hair.
She said: "What the doctor said really got to me. The most simple thing a child can have is to have their hair washed and a bath.
"Caoilte gets a bath in the hospice once a month and she loves it. We do our best at home but she can only be bed-bathed and I need to keep running getting water."
Fiona said she felt under mounting pressure to find an accessible home so Caoilte could use a power chair, which will be delivered next month.
She said: "We have nowhere to put the chair and nowhere for Caoilte to go in it as she could not fit through the doors here.
"Caoilte's mind is not affected by her illness so she is aware of everything going on. She deserves better."
Fiona said every day was precious for her daughter, who was not expected to survive beyond infancy.
She said: "Most children like her die before their first birthday and we were told doctors did not expect her to survive long enough to be diagnosed at three months.
"Every child needs space to relax away from everybody. When visitors come they have to be in her bedroom because it is also the living room.
"There is no privacy to change her nappy. She has to forego her dignity to go to a hospice for bath. I am depressed that she is now five and has not had her own bedroom."
Fiona said she tried to take Caoilte, a pupil at Oakwood School and Assessment Centre, out of the house as often as possible because she struggles to cope with the clutter of their house.
She said she had recently refused an offered of hostel accommodation, which she considered inappropriate for her child.
She added: "Caoilte is a happy child who loves everything but how much longer do we have to live like this? I am really not hopeful any more but if we were finally offered a bungalow it would be like gold to us."
North Belfast SDLP MLA Nichola Mallon, who has represented Caoilte's family, said it was disgraceful "no resolution was in sight".
She said: "What kind of a society are we that in 2018, a disabled child with a life limiting condition is forced to travel to the Children's Hospice to get a bath and is suffering head sores because she can't get washed properly in her home.
"For two years, I have made multiple representations on their behalf and Caoilte has suffered enough.
"She is being cruelly denied her privacy, her dignity and her basic rights. She has a right to a home where she can get washed, where she has the privacy of a bedroom and where there is the space to safely store all of her medical equipment.
"All other options have been exhausted. A house must either be bought or built for this family now."
A Housing Executive spokesperson said: "We are deeply sympathetic to the family in this case, which is extremely complex and we have worked over a number of years to find an appropriate housing solution for them.
"This family are NB Housing Association tenants with a high level of housing points, allowing them to transfer to a more suitable property.
"Unfortunately, there are no available converted properties in their areas of choice, which are areas of high housing demand and low housing turnover with particularly limited availability for three bed, wheelchair accessible accommodation.
"We have asked the family to look at areas beyond their initial choices and have identified options for them, including the use of a vacant site in North Belfast where a dwelling could have been placed, but this was refused.
"A suitable, wheelchair friendly property was also sourced, but this was again turned down as it may have been outside the geographical boundary of the Belfast Health and Social Care Trust.
"Earlier this year, a house in West Belfast was identified, but was ruled out by an Occupational Therapist as unsuitable as equipment at the home would not be suitable for the needs of the child.


text:
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HomeUncategorizedThe detection of periapical pathosis us
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