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1/ 03.04.19
Mariana Dias
Lab Prof. Engelhardt
Corina Frick
Lab Prof. Mehling
Talk 1: Ultrastructural 3D analysis of T-cell diapedesis across the Blood-Brain Barrier
(Mariana Dias, PhD student at Engelhardt lab, TKI, University of Bern)
In multiple sclerosis, autoaggressive T cells cross the blood-brain barrier (BBB) and enter the CNS parenchyma promoting inflammation, demyelination and eventually neurodegeneration. T-cell diapedesis across the BBB can occur via a paracellular pathway across the endothelial junctions or via a transcellular pathway, through a pore across the endothelial cell body. However, the precise mechanisms underlying paracellular versus transcellular T-cell diapedesis across the BBB remain to be explored. Thus, the aim of the present study is to determine the subcellular structures formed during T-cell interaction with the BBB. To do so, we combined in vitro live cell imaging and serial block face scanning electron microscopy (SBF-SEM), to perform the analysis in a 3D ultrastructural level.
Talk 2: Nano-scale microfluidics to study 3D chemotaxis at the single cell level
(Corina Frick, PhD student at Mehling lab, Department of Biomedicine, University of Basel)
Chemotaxis of immune cells plays an important role in immune surveillance and inflammation. The mode of migration depends highly on microenvironmental factors such as exposure to 2D surfaces or 3D matrices. We have developed a microfluidic migration device which allows to study immune cell migration in a 3D collagen environment in highly controlled diffusion-based chemokine gradients.
Funding Opportunities for Young
Neuroscientists
Leah Witton
Grants Office
Simone Rufener
Talk: Career and project funding opportunities in neuroscience for early career researchers
Sleep Neuroscience
Lukas Oesch
Adamantidis Lab
Arndt-Lukas Klaassen
Rainer Lab
Talk 1: Activation of hypothlamic inhibitory neurons during REM sleep stabilizes appetite
(Lukas Oesch, PhD student in the Adamantidis Lab, University of Bern)
We show that GABAergic neurons in the lateral hypothalamus of mice simulataneously encode instantaneous feeding behavior and feeding history. Populations of feeding active neurons are activated during REM sleep and their silencing specifically durgin REM sleep but not wakefulness decreases subsequent food intake.
Talk 2: Basal forebrain contributions to brain state regulation during auditory learning and sleep
(Arndt-Lukas Klaassen, PhD student in the Rainer Lab, University of Fribourg)
The basal forebrain (BF) projections play an important role in modulating neural network states, for example by enhancing cortical responsivity as well as contributing to wake/sleep regulation. The BF projections regulate cerebral cortical function by providing the major source of cholinergic as well as GABA- and glutamatergic input to the neocortex. Here, we aim to investigate the neuromodulatory influence of the BF on brain state regulation by combining optogenetic stimulation in the ventral pallidum of the BF with electrophysiology in the anterior cingulate cortex (ACC) in rats.
Gerd Tinkhauser
Eduardo Martin Moraud
Talk 1: Combining Deep Brain Stimulation with physiology in Parkinson's Disease
(Gerd Tinkhauser, Inselspital, Bern)
Deep brain stimulation is an established treatment for Parkinson's disease and other movement disorders. This therapy however is limited by the slow manual and error-prone programming algorithms to identify the optimal stimulation site and by the stimulation induced side-effects. Electrophysiological recordings from the basal ganglia, the structures where the electrodes are implanted, revealed the presence of electrophysiological markers related to the motor symptoms. Studying distribution and behavioral characteristics of these markers led to the first pilot studies toward automatized programming and closed-loop stimulation in Parkinson's disease.
Talk 2: Towards closed-loop neuromodulation of brain and spinal circuits to alleviate gait and balance deficits in Parkinson's disease
(Eduardo Martin Moraud, CHUV, Lausanne)
Impairments of gait and balance are amongst the most incapacitating and least well-understood symptoms of Parkinson's disease (PD). Well-established neuromodulation therapies for PD, which are highly effective for the treatment of upper-limb motor signs, often exhibit modest results to alleviate gait deficits. This discrepancy is presumably due to the divergence in the nature and dynamics of the circuits that control leg versus upper limb movements.
To date, the brain signatures underlying leg motor function and dysfunction, their involvement in leg muscle recruitment and force modulation across locomotor activities, and their utility to help refine therapies remains unclear. Similarly, the impact of combining brain and spinal neuromodulation therapies to specifically address locomotor deficits remains controversial.
In this talk, I will present results on these two questions:
First, we aimed to identify the neural correlates of leg force modulation from local field potentials (LFPs) recorded from deep brain stimulation electrodes implanted in the subthalamic nucleus (STN) of patients with PD, and to leverage this framework to develop decoding algorithms able to automatically predict leg force intention in real-time.
Second, we employed brain-decoded intention to trigger and control spinal cord neuromodulation therapies during unconstrained movements in non-human primate model of PD.
These combined results confirm the capacity to leverage brain signals to decode force production and leg motor intention in real-time, and to further exploit them to provide personalised therapies of brain and spinal cord to address gait deficits.
Network Dynamics of
Robert Ganley
Lab Prof. Zeilhofer
Mario A. Acuña
Lab Prof. Nevian
Talk 1: Cells and circuitry of stress-induced analgesia. Targets for chronic pain treatments ?
(Robert Ganley, Postdoc at Zeilhofer lab, University of Zurich)
We have identified a population of spinal cord inhibitory interneurons that are critical components of swim stress-induced analgesia, which are identified by the expression of the transcription factor Gbx1. These Gbx1-expressing interneurons are required for stress-induced analgesia but are not required for pain perception under normal conditions, and their activation is sufficient to produce a robust analgesia in all tested pain modalities. Spinal Gbx1-expressing neurons and the circuits that activate them represent potential targets for the treatment of chronic pain.
Talk 2: Neuronal network dynamics and sensory representation in the ACC
(Mario A. Acuña, Postdoc at Nevian lab, University of Bern)
Chronic pain affects to 20% of the European population; therefore, understanding the processes underlying such pain chronification is imperative. Accumulating evidence indicates that abnormal neuronal plasticity and a resulting hyperactivity of the anterior cingulate cortex (ACC) is the cause for the manifestation of the emotional distress that characterizes chronic pain conditions. However, how the functional organization of ACC neuronal microcircuits is affected in chronic pain is poorly understood. In this talk I will present the current advances we are making towards an understanding on how pain is represented in the mouse ACC using in-vivo 2-photon calcium imaging.
What is beyond Academia ?
Dr. Armand Mensen
Swiss 3RCC
Dr. Charles Finsterwald
GliaPharm
Talk 1: From Psychologist, to Neuroscientist, to Scientific Officer
(Armand Mensen, Swiss 3RCC)
Armand will talk about his career path from obtaining his PhD, through his 6 year Post-doc career, and how he ended up as a Scientific Officer at the Swiss 3RCC, with a foot still in the door of the academic track... just in case.
Talk 2: From academia to a biotech startup
(Charles Finsterwald, GliaPharm)
GliaPharm is a Swiss biotech start-up company based in Geneva that develops innovative treatments against neurodegenerative disorders. GliaPharm's therapeutic approach stems from pioneering work pursued for many years by Prof. Magistretti's laboratory at EPFL (Lausanne). Based on the understanding of the role of glial cells in the course of neurodegenerative disorders, and the importance of the so-called astrocyte-neuron lactate shuttle (ANLS), GliaPharm is developing innovative therapeutic approaches by targeting those mechanisms.
GliaPharm was created in 2016 as a spinoff from EPFL, and moved one year later to the Campus Biotech in Geneva, where it has since been pursuing its drug development activities, currently at the preclinical stage. GliaPharm's objective is to enter into clinical trials with its lead molecule by early 2022.
Dr. Charles Finsterwald is co-founder and the Chief Scientific Officer at GliaPharm. During his talk, Dr. Finsterwald will describe GliaPharm's scope, therapeutic approach and history. He will also discuss his personal experience as a co-cofounder and working in a start-up company.
Intracranial hemorrhage
Martina Göldlin, MD
Inselspital, Bern
Kevin Akeret, MD
University Hospital Zurich
Talk 1: Risk factors and mechanisms of primary intracerebral haemorrhage from a clinical research perspective
(Martina Göldlin, Inselpital)
Intracerebral haemorrhage (ICH) is a devastating disease with few evidence-based therapeutic options, high morbidity and mortality. Understanding the risk factors and underlying mechanisms is key to improve future research approaches for prevention and therapy of ICH. This talk will provide insights from a clinical research perspective.
Talk 2: The pathophysiology of secondary brain damage after intracerebral hemorrhage and potential therapeutic targets
(Kevin Akeret, University Hospital Zurich)
After intracerebral hemorrhage, patients often deteriorate within days to a few weeks due to the development of secondary brain damage. Secondary neurodamage after intracerebral haemorrhage has a complex multiphasic pathopysiology. A better understanding of its individual phases, identification of its mediators and specific therapeutic targeting of such has the potential to minimize the development of secondary brain damage after intracerebral hemorrhage and to improve patient outcome.


Dublin Choral Foundation – a provider of musical education from childhood to adulthood.
Today's bright young singers become tomorrow's accomplished, confident, caring and creative citizens.
As members of Piccolo Lasso boys and girls (aged 8-15) experience a wide variety of music. Already since September 2017 they have appeared in the National Concert Hall on three occasions – Sept 23rd, Dec 13th and Dec 23rd – and have performed in Westminster Cathedral, London (Oct 28th 2017). Their repertoire is wide reaching and during the academic year 2017-18 includes Mozart's 'Coronation' Mass, Delibes: 'Messe Breve'; Faure: Messe Basse; Menschick Missa Pueri Cantores and Seoirse Bodley Missa Brevis in Angustiis.
Members of Piccolo Lasso who commit to the twice-weekly rehearsal schedule become proficient at reading music, singing in ensemble and solo singing. They grow in confidence just by participating. The experience they gain in developing musical skills and in working as team members and team leaders results in improved focus and concentration and extends to all other areas of their lives. Children who demonstrate exceptional talent are prepared for an adult life as a musician – both vocal and instrumental. Choristers of today become the accomplished, confident, caring and creative citizens of tomorrow.
Under the baton of Dr Ite O'Donovan, Piccolo Lasso is much in demand in Ireland and over 21 years has collaborated with other artistic groups including Opera Ireland, Opera Theatre Company (Carmen), Lismore Opera (The Magic Flute), Dublin City Council's Opera in the Open (The Magic Flute , Carmen) and Junk Ensemble Modern Dance Company and Theatre Lovett.
Travel: At the end of December, 2015 Piccolo Lasso were in Rome singing at various venues including St Peter's Basilica. A number of singers visited Salzburg in July 2016 and a group travelled to Malta in February 2017. Piccolo Lasso made a return visit to Westminster Cathedral on Saturday October 28th 2017.
Interested children are invited along to our open rehearsals on Thursdays. Children 8/9 to 13 years 5.30-6.25.
Initial Class for Children aged 5 to 8 years take place on Thursdays 5.00 – 5.30. Parents welcome!


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Petr Fiala (AFI: ; Brno, 1 de setembro de 1964) é um político e cientista político checo, atual Primeiro-ministro da República Tcheca desde 28 de novembro de 2021 e líder do Partido Democrático Cívico (ODS) desde 2014. Foi anteriormente Ministro da Educação, Juventude e Esportes de 2012 a 2013.

Biografia
Ele se formou na Universidade de Brno (1983-1988) em língua e história tcheca, depois do qual trabalhou como historiador em um museu. Na década de 1980 esteve envolvido em atividades cívicas independentes contra a ditadura comunista. Depois de novembro de 1989 fundou o campo da ciência política. Os cargos que ocupou desde então incluem chefe do Departamento de Ciência Política (1993–2002) e do Departamento de Relações Internacionais e Estudos Europeus (2002–2004), diretor do Instituto Internacional de Ciência Política (1996–2004), diretor do Instituto de Pesquisa Política Comparada (2005–2011) e reitor da Faculdade de Estudos Sociais da Universidade de Masaryk (2004).

Como reitor, atuou dois mandatos como chefe da Universidade Masaryk (2004–2011), que durante esse período se tornou a universidade tcheca mais popular e uma das principais instituições de ensino e pesquisa da Europa Central. Durante muitos anos trabalhou para instituições e organismos com foco no ensino universitário e na investigação na República Checa e no estrangeiro, e foi também presidente da Conferência de Reitores Checos (2009–2011). Ocupou vários cargos públicos e profissionais, incluindo, por exemplo, membro da Diretoria do Instituto para o Estudo dos Regimes Totalitários, da Comissão de Credenciamento, da vice-presidência do Conselho de Pesquisa, Desenvolvimento e Inovação, e atuou como o principal conselheiro científico do primeiro-ministro. Em seu trabalho científico, ele se especializou em ciência política comparada, política europeia e pensamento político conservador. É autor de mais de 20 livros e 300 estudos profissionais publicados na República Checa e no estrangeiro.

Em 2012–2013 foi Ministro da Educação no governo de Petr Nečas; ele conseguiu trazer estabilidade ao departamento e seu trabalho conceitual e convincente rapidamente conquistou a confiança do público em geral.

Em outubro de 2013, ele era um candidato apartidário pelo ODS da Morávia do Sul e foi eleito membro do parlamento. Ingressou no ODS em 7 de novembro de 2013 e foi eleito líder do partido em janeiro de 2014. Ele manteve sua liderança em janeiro de 2016, 2018 e 2020. Em outubro de 2017 foi o líder nacional do ODS e da Morávia do Sul nas eleições, nas quais o ODS se tornou o líder segundo partido político mais forte. Em novembro do mesmo ano foi eleito Vice-Presidente da Câmara dos Deputados do Parlamento da República Checa. No outono de 2020, ele se tornou o líder nacional da recém-formada coalizão eleitoral SPOLU (ODS, KDU-ČSL, TOP 09). Em outubro de 2021, a coligação SPOLU venceu as eleições parlamentares com uma percentagem de 27,8 % (1 493 905 votos).

Vida pessoal
Petr Fiala é casado com a bióloga Jana Fialová, que a conheceu enquanto estudante durante a Revolução de Veludo. Eles têm três filhos. Fiala é católico e foi batizado em 1986.

Políticos da Chéquia

redpajama_set_name: RedPajamaWikipedia


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Family of 16-year-old Texas teen who killed 4 in drunken wreck settles some, not all, cases
FILE - This Dec. 2013 file image taken from a video by KDFW-FOX 4, Ethan Couch, who killed four people in a drunken wreck in 2013, appears for his court hearing in Fort Worth, Texas. Couch's family has settled with some, but not all, of the victims suing them. Court records indicate the family has settled three lawsuits brought against them, including suits involving three of the four people who died. But at least four other lawsuits have not been settled. (AP Photo/KDFW-FOX 4, File) (The Associated Press)
DALLAS – The family of a North Texas teen who killed four people in a drunken wreck has reached settlements with some, but not all, of the families of the teen's victims, court records show.
Ethan Couch was given 10 years' probation for intoxication manslaughter in a wreck last year that left several people severely injured. His case and sentence drew national attention due to a defense expert's testimony that Couch's parents had coddled him into a sense of irresponsibility — a condition the expert called "affluenza."
Court records in Fort Worth indicate Couch's family has settled three lawsuits, including with families of three of the people killed: Breanna Mitchell, whose car had stopped on a rural Tarrant County road; and Hollie and Shelby Boyles, a mother and daughter who were trying to help.
The terms of those settlements were not disclosed.
The third settlement is with the parents of Isaiah McLaughlin, who was a 13-year-old passenger in the car of local minister Brian Jennings, who was also killed after stopping to help Mitchell.
According to a court filing, McLaughlin's family and attorneys will receive a $37,500 payment. The boy will get an annuity of about $13,000 a year for the next five years, as well as a $10,000 payment when he turns 25.
Couch was drunk and had prescription drugs in his system when he plowed his family's Ford pickup truck into the crowd of people helping Mitchell.
At least four lawsuits have not been settled, according to court records. Jennings' widow and two children are still discussing a settlement. Also pending are cases brought by the families of Sergio Molina and Solaiman Mohmand, teens from suburban Keller who were riding in the bed of Couch's pickup and were severely hurt in the crash, and Lucas McConnell, a 12-year-old passenger in Jennings' car.
Molina was paralyzed in the crash and can communicate only by blinking. Mohmand broke several bones and suffered internal injuries.
Couch's blood-alcohol level was three times the legal limit for an adult and traces of Valium were found in his blood after the crash.
Couch faced 20 years in prison after admitting to the crash, but State District Judge Jean Boyd sentenced him to 10 years' probation — a sentence ripped by prosecutors, many of the victims' families and in nationwide commentary.
An attorney for Couch did not return a phone message Wednesday.
Follow Nomaan Merchant on Twitter at http://www.twitter.com/nomaanmerchant.

redpajama_set_name: RedPajamaCommonCrawl


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