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26 USC 7482: Courts of review Text contains those laws in effect on January 28, 2020
From Title 26-INTERNAL REVENUE CODESubtitle F-Procedure and AdministrationCHAPTER 76-JUDICIAL PROCEEDINGSSubchapter D-Court Review of Tax Court Decisions
§7482. Courts of review
(a) Jurisdiction
The United States Courts of Appeals (other than the United States Court of Appeals for the Federal Circuit) shall have exclusive jurisdiction to review the decisions of the Tax Court, except as provided in section 1254 of Title 28 of the United States Code, in the same manner and to the same extent as decisions of the district courts in civil actions tried without a jury; and the judgment of any such court shall be final, except that it shall be subject to review by the Supreme Court of the United States upon certiorari, in the manner provided in section 1254 of Title 28 of the United States Code.
(2) Interlocutory orders
When any judge of the Tax Court includes in an interlocutory order a statement that a controlling question of law is involved with respect to which there is a substantial ground for difference of opinion and that an immediate appeal from that order may materially advance the ultimate termination of the litigation, the United States Court of Appeals may, in its discretion, permit an appeal to be taken from such order, if application is made to it within 10 days after the entry of such order. Neither the application for nor the granting of an appeal under this paragraph shall stay proceedings in the Tax Court, unless a stay is ordered by a judge of the Tax Court or by the United States Court of Appeals which has jurisdiction of the appeal or a judge of that court.
(B) Order treated as Tax Court decision
For purposes of subsections (b) and (c), an order described in this paragraph shall be treated as a decision of the Tax Court.
(C) Venue for review of subsequent proceedings
If a United States Court of Appeals permits an appeal to be taken from an order described in subparagraph (A), except as provided in subsection (b)(2), any subsequent review of the decision of the Tax Court in the proceeding shall be made by such Court of Appeals.
(3) Certain orders entered under section 6213(a)
An order of the Tax Court which is entered under authority of section 6213(a) and which resolves a proceeding to restrain assessment or collection shall be treated as a decision of the Tax Court for purposes of this section and shall be subject to the same review by the United States Court of Appeals as a similar order of a district court.
(b) Venue
Except as otherwise provided in paragraphs (2) and (3), such decisions may be reviewed by the United States court of appeals for the circuit in which is located-
(A) in the case of a petitioner seeking redetermination of tax liability other than a corporation, the legal residence of the petitioner,
(B) in the case of a corporation seeking redetermination of tax liability, the principal place of business or principal office or agency of the corporation, or, if it has no principal place of business or principal office or agency in any judicial circuit, then the office to which was made the return of the tax in respect of which the liability arises,
(C) in the case of a person seeking a declaratory decision under section 7476, the principal place of business, or principal office or agency of the employer,
(D) in the case of an organization seeking a declaratory decision under section 7428, the principal office or agency of the organization,
(E) in the case of a petition under section 6234, the principal place of business of the partnership,
(F) in the case of a petition under section 6015(e), the legal residence of the petitioner, or
(G) in the case of a petition under section 6320 or 6330-
(i) the legal residence of the petitioner if the petitioner is an individual, and
(ii) the principal place of business or principal office or agency if the petitioner is an entity other than an individual.
If for any reason no subparagraph of the preceding sentence applies, then such decisions may be reviewed by the Court of Appeals for the District of Columbia. For purposes of this paragraph, the legal residence, principal place of business, or principal office or agency referred to herein shall be determined as of the time the petition seeking redetermination of tax liability was filed with the Tax Court or as of the time the petition seeking a declaratory decision under section 7428 or 7476, or the petition under section 6234, was filed with the Tax Court.
(2) By agreement
Notwithstanding the provisions of paragraph (1), such decisions may be reviewed by any United States Court of Appeals which may be designated by the Secretary and the taxpayer by stipulation in writing.
(3) Declaratory judgment actions relating to status of certain governmental obligations
In the case of any decision of the Tax Court in a proceeding under section 7478, such decision may only be reviewed by the Court of Appeals for the District of Columbia.
(c) Powers
(1) To affirm, modify, or reverse
Upon such review, such courts shall have power to affirm or, if the decision of the Tax Court is not in accordance with law, to modify or to reverse the decision of the Tax Court, with or without remanding the case for a rehearing, as justice may require.
(2) To make rules
Rules for review of decisions of the Tax Court shall be those prescribed by the Supreme Court under section 2072 of title 28 of the United States Code.
(3) To require additional security
Nothing in section 7483 shall be construed as relieving the petitioner from making or filing such undertakings as the court may require as a condition of or in connection with the review.
(4) To impose penalties
The United States Court of Appeals and the Supreme Court shall have the power to require the taxpayer to pay to the United States a penalty in any case where the decision of the Tax Court is affirmed and it appears that the appeal was instituted or maintained primarily for delay or that the taxpayer's position in the appeal is frivolous or groundless.
(Aug. 16, 1954, ch. 736, 68A Stat. 890 ; Pub. L. 89–713, §3(c), Nov. 2, 1966, 80 Stat. 1109 ; Pub. L. 91–172, title IX, §960(h)(2), Dec. 30, 1969, 83 Stat 735; Pub. L. 93–406, title II, §1041(b)(3), Sept. 2, 1974, 88 Stat. 950 ; Pub. L. 94–455, title X, §1042(d)(2)(A), (B), title XIII, §1306(b)(4), (5), title XIX, §1906(b)(13)(A), Oct. 4, 1976, 90 Stat. 1638 , 1639, 1719, 1834; Pub. L. 95–600, title III, §336(c)(1), Nov. 6, 1978, 92 Stat. 2842 ; Pub. L. 97–164, title I, §154, Apr. 2, 1982, 96 Stat. 47 ; Pub. L. 97–248, title IV, §402(c)(15), Sept. 3, 1982, 96 Stat. 668 ; Pub. L. 98–369, div. A, title I, §131(e)(2)(A), July 18, 1984, 98 Stat. 665 ; Pub. L. 99–514, title XV, §1558(a), (b), title XVIII, §§1810(g)(2), 1899A(60), Oct. 22, 1986, 100 Stat. 2757 , 2758, 2828, 2962; Pub. L. 100–647, title VI, §6243(b), Nov. 10, 1988, 102 Stat. 3750 ; Pub. L. 101–239, title VII, §7731(b), Dec. 19, 1989, 103 Stat. 2401 ; Pub. L. 105–34, title XII, §§1222(b)(3), 1239(d), Aug. 5, 1997, 111 Stat. 1019 , 1028; Pub. L. 114–74, title XI, §1101(f)(13), Nov. 2, 2015, 129 Stat. 638 ; Pub. L. 114–113, div. Q, title IV, §423(a), Dec. 18, 2015, 129 Stat. 3123 .)
2015-Subsec. (b)(1). Pub. L. 114–74, §1101(f)(13)(C), substituted "section 6234" for "section 6226, 6228(a), or 6234(c)" in concluding provisions.
Subsec. (b)(1)(E). Pub. L. 114–74, §1101(f)(13)(A), which directed amendment of subpar. (E) by substituting "section 6234" for "section 6226, 6228, 6247, or 6252", was executed by making the substitution for "section 6226, 6228(a), 6247, or 6252" to reflect the probable intent of Congress.
Subsec. (b)(1)(F). Pub. L. 114–113, §423(a), added subpar. (F).
Pub. L. 114–74, §1101(f)(13)(B), struck out subpar. (F) which read as follows: "in the case of a petition under section 6234(c)-
"(i) the legal residence of the petitioner if the petitioner is not a corporation, and
"(ii) the place or office applicable under subparagraph (B) if the petitioner is a corporation."
Subsec. (b)(1)(G). Pub. L. 114–113, §423(a), added subpar. (G).
1997-Subsec. (b)(1). Pub. L. 105–34, §1239(d)(2), substituted ", 6228(a), or 6234(c)" for "or 6228(a)" in concluding provisions.
Subsec. (b)(1)(E). Pub. L. 105–34, §1222(b)(3), substituted ", 6228(a), 6247, or 6252" for "or 6228(a)".
Subsec. (b)(1)(F). Pub. L. 105–34, §1239(d)(1), added subpar. (F).
1989-Subsec. (c)(4). Pub. L. 101–239 substituted "penalties" for "damages" in heading and amended text generally. Prior to amendment, text read as follows: "The United States Court of Appeals and the Supreme Court shall have power to impose damages in any case where the decision of the Tax Court is affirmed and it appears that the notice of appeal was filed merely for delay."
1988-Subsec. (a)(3). Pub. L. 100–647 added par. (3).
1986-Subsec. (a). Pub. L. 99–514, §1558(a), (b), inserted par. (1) designation and heading "In general" before existing text and realigned its margin, and added par. (2).
Subsec. (b)(1). Pub. L. 99–514, §1810(g)(2), substituted "section 7428 or 7476" for "section 7428, 7476, or 7477" in last sentence.
Subsec. (b)(1)(E). Pub. L. 99–514, §1899A(60), substituted "partnership." for "partnership,".
1984-Subsec. (b)(1)(D) to (F). Pub. L. 98–369 struck out subpar. (D) which provided that venue in the case of a person seeking declaratory judgment under section 7477 be the legal residence of such person if such person is not a corporation, or the principal place of business or principal office or agency of such person if such person is a corporation, and redesignated subpars. (E) and (F) as (D) and (E), respectively.
1982-Subsec. (a). Pub. L. 97–164 inserted "(other than the United States Court of Appeals for the Federal Circuit)" after "The United States Courts of Appeals".
Subsec. (b)(1). Pub. L. 97–248 added subpar. (F), and in provisions following subpar. (F) inserted ", or the petition under section 6226 or 6228(a)," after "or 7477".
1978-Subsec. (b)(1). Pub. L. 95–600, §336(c)(1)(A), substituted "provided in paragraphs (2) and (3)" for "provided in paragraph (2)".
Subsec. (b)(3). Pub. L. 95–600, §336(c)(1)(B), added par. (3).
1976-Subsec. (b)(1)(D). Pub. L. 94–455, §1042(d)(2)(A), added subpar. (D).
Subsec. (b)(1)(E). Pub. L. 94–455, §1306(b)(4), added subpar. (E).
Subsec. (b)(1). Pub. L. 94–455, §§1042(d)(2)(B), 1306(b)(5), in provisions following subpar. (E), substituted "no subparagraph of the preceding sentence applies" for "subparagraph (A), (B), and (C) do not apply" and "section 7428, 7476, or 7477" for "section 7476".
Subsec. (b)(2). Pub. L. 94–455, §1906(b)(13)(A), struck out "or his delegate" after "Secretary".
1974-Subsec. (b)(1). Pub. L. 93–406 added subpar. (C) and, in provisions following subpar. (C), substituted "If for any reason subparagraph (A), (B), and (C) do not apply" for "If for any reason neither subparagraph (A) nor (B) applies", and inserted provisions referring to the time the petition seeking a declaratory decision under section 7476 was filed with the Tax Court.
1969-Subsec. (c). Pub. L. 91–172 substituted "section 2072 of title 28" for "section 2074 of title 28" in par. (2) and struck out provision for the applicability of rules adopted under authority of section 1141(c)(2) of the Internal Revenue Act of 1939 until such time as rules prescribed by the Supreme Court under section 2072 of title 28 become effective and, in par. (4), substituted "notice of appeal" for "petition".
1966-Subsec. (b)(1). Pub. L. 89–713 substituted provisions requiring that appeals from Tax Court decisions be made to the Court of Appeals for the circuit in which the taxpayer resides, in the case of a taxpayer other than a corporation, and, in the case of appeals by corporations, to the Court of Appeals for the circuit in which the corporation has its principal place of business or principal office or agency for provisions prescribing review by the Court of Appeals for the circuit in which was located the office to which was made the return of the tax in respect of which the liability arose, and inserted provision for the time of determining legal residence, place of business, or principal office or agency.
Pub. L. 114–113, div. Q, title IV, §423(b), Dec. 18, 2015, 129 Stat. 3124 , provided that:
"(1) In general.-The amendments made by this section [amending this section] shall apply to petitions filed after the date of enactment of this Act [Dec. 18, 2015].
"(2) Effect on existing proceedings.-Nothing in this section shall be construed to create any inference with respect to the application of section 7482 of the Internal Revenue Code of 1986 with respect to court proceedings filed on or before the date of the enactment of this Act."
Amendment by Pub. L. 114–74 applicable to returns filed for partnership taxable years beginning after Dec. 31, 2017, with certain exceptions, see section 1101(g) of Pub. L. 114–74, set out as an Effective Date note under section 6221 of this title.
Amendment by section 1222(b)(3) of Pub. L. 105–34 applicable to partnership taxable years beginning after Dec. 31, 1997, see section 1226 of Pub. L. 105–34, as amended, set out as a note under section 6011 of this title.
Amendment by section 1239(d) of Pub. L. 105–34 applicable to partnership taxable years ending after Aug. 5, 1997, see section 1239(f) of Pub. L. 105–34, set out as a note under section 6501 of this title.
Amendment by Pub. L. 101–239 applicable to positions taken after Dec. 31, 1989, in proceedings which are pending on, or commenced after such date, see section 7731(d) of Pub. L. 101–239, set out as a note under section 6673 of this title.
Amendment by Pub. L. 100–647 applicable to orders entered after Nov. 10, 1988, see section 6243(c) of Pub. L. 100–647, set out as a note under section 6213 of this title.
Pub. L. 99–514, title XV, §1558(c), Oct. 22, 1986, 100 Stat. 2758 , provided that: "The amendments made by this section [amending this section] shall apply to any order of the Tax Court entered after the date of the enactment of this Act [Oct. 22, 1986]."
Amendment by section 1810(g)(2) of Pub. L. 99–514 effective, except as otherwise provided, as if included in the provisions of the Tax Reform Act of 1984, Pub. L. 98–369, div. A, to which such amendment relates, see section 1881 of Pub. L. 99–514, set out as a note under section 48 of this title.
Amendment by Pub. L. 98–369 applicable to transfers or exchanges after Dec. 31, 1984, in taxable years ending after such date, with special rules for certain transfers and ruling requests before Mar. 1, 1984, see section 131(g) of Pub. L. 98–369, set out as a note under section 367 of this title.
Amendment by Pub. L. 97–248 applicable to partnership taxable years beginning after Sept. 3, 1982, with provision for the applicability of the amendment to any partnership taxable year ending after Sept. 3, 1982, if the partnership, each partner, and each indirect partner requests such application and the Secretary of the Treasury or his delegate consents to such application, see section 407(a)(1), (3) of Pub. L. 97–248, set out as a note under section 702 of this title.
Amendment by Pub. L. 97–164 effective Oct. 1, 1982, see section 402 of Pub. L. 97–164, set out as a note under section 171 of Title 28, Judiciary and Judicial Procedure.
Amendment by Pub. L. 95–600 applicable to requests for determinations made after Dec. 31, 1978, see section 336(d) of Pub. L. 95–600, set out as an Effective Date note under section 7478 of this title.
Amendment by section 1042(d)(2)(A), (B) of Pub. L. 94–455 applicable with respect to pleadings filed with the Tax Court after Oct. 4, 1976, but only with respect to transfers beginning after Oct. 9, 1975, see section 1042(e)(1) of Pub. L. 94–455, set out as a note under section 367 of this title.
Amendment by section 1306(b)(4), (5) of Pub. L. 94–455 applicable with respect to pleadings filed with the United States Tax Court, the district court of the United States for the District of Columbia, or the United States Court of Claims more than 6 months after Oct. 4, 1976 but only with respect to determinations (or requests for determinations) made after Jan. 1, 1976, see section 1306(c) of Pub. L. 94–455, set out as an Effective Date note under section 7428 of this title.
Amendment by Pub. L. 93–406 applicable to pleadings filed more than one year after Sept. 2, 1974, see section 1041(d) of Pub. L. 93–406, set out as an Effective Date note under section 7476 of this title.
Amendment by Pub. L. 91–172 effective 30 days after Dec. 30, 1969, see section 962(f) of Pub. L. 91–172, set out as a note under section 7483 of this title.
Amendment by Pub. L. 89–713 applicable to all decisions of the Tax Court entered after Nov. 2, 1966, see section 3(d) of Pub. L. 89–713, set out as a note under section 7422 of this title.


The Good The Pure Evoke Flow is a classic Wi-Fi radio done right, offering free Internet radio broadcasts, podcasts, local network streaming, and FM radio in an upscale, portable box with good sound quality.
The Bad The elegance of the touch-sensitive interface comes at the cost of usability. Remote and battery pack cost extra. Many popular music services, such as Pandora, Slacker, or Rhapsody, are not supported. The speaker is mono, and the terrestrial radio doesn't pick up AM broadcasts.
The Bottom Line The Pure Evoke Flow Wi-Fi radio offers superb construction and relatively full sound, but the music streaming options are stuck in the past.
In spite of all the ways we have to listen to music today, there's still nothing quite as comforting as switching on a radio and tuning in your favorite station. As an updated take on the classic portable radio, the Pure Evoke Flow ($229) expands beyond your local FM broadcasts, offering over 15,000 free Internet radio stations ranging from standards such as BBC and ESPN, to niche independents.
If your interest in radio is primarily about hearing great music, products such as the Logitech Squeezebox Radio, or even the Apple iPod Touch, offer a selection of streaming music services that the Evoke, unfortunately, can't match. But if your tastes span beyond music, into news, talk radio, and sports, the Evoke Flow offers a streamlined and well-built solution for hearing the world's online broadcasts.
Taking a break from the molded-plastic look of most of today's electronics, the Pure Evoke Flow is unapologetically boxy and retro. Constructed primarily of farmed wood, and finished with a thick piano gloss, the radio's design is a nod to the past and provides a reassuring sturdiness that is rare for this price range.
We wouldn't blame you if you mistook the radio for a lunchbox, since its 5.5-inch x 8.25-inch x 3.25-inch dimensions and solid metal handle fit easily within our grade-school memories. Your old lunchbox was never this cool though (no, not even the A-Team one). Using a combination of touch-sensitive buttons, old-fashioned knobs, an OLED screen, and a 3-inch speaker, the Evoke Flow strikes an intriguing balance between old and new.
On the back of the radio you have the FM antenna, power-adapter socket, aux input, stereo output, headphone output, aux speaker out, and USB port. Although we think it would be more convenient to have the headphone output located on the front panel, it's nonetheless an impressive amount of connectivity. One port not offered, however, is the Ethernet input included on the rival Squeezebox Radio. For an Internet radio geared toward portability, the lack of a hardwired Internet connection isn't a deal-breaker for us, but it's worth noting for the sake of comparison.
Also included on the back of the radio is a compartment for a proprietary rechargeable battery pack. While we can appreciate the ecological high-road Pure has taken by using a rechargeable pack, the $59 price tag is a steep premium for portability. As the total price of a truly portable Wi-Fi radio inches towards $300, the alternative of pairing an Internet radio-friendly $199 iPod Touch with a portable speaker becomes harder to resist.
As much as we enjoy the retro-futuristic look of the Evoke Flow's chrome plastic knobs and touch controls--the combo falls short as a user interface. The three illuminated touch-buttons are defined by labels above them on the screen. In one context they may serve as an option key or preset control, in another they be used as links to station search or listings. Combined with the nearby back arrow control and a dial for scrolling menus and making selections, the interface as a whole does a commendable job of doing more with less.
We did experience some initial frustration with the radio's controls, however. As with most Wi-Fi radios, entering in your network password using dial and onscreen keyboard can be tedious, though you only need to do it once. Our more nagging frustration was the poor breadcrumb navigation for backing out of some menus. For example, after tuning-in a classic rock Internet radio station using the search menu, hitting the back button takes you back to the main menu instead of the search results. To return to the search menu, we had to twist the selection knob to access the station listings, then press one of the contextual buttons to bring up search. It's hardly as intuitive as simply allowing the back arrow to step you one page back, but you get the hang of it.
The term "radio" encompasses many types of audio today, including AM/FM radio, satellite radio, online-only music broadcasts, and personalized Internet music services. No single device excels at delivering radio in all its forms. It's up to you to figure out what radio services are most important to you, and what devices will best deliver them.


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What Does Cocaine Mean?
Cocaine is a highly addictive drug that has a stimulant effect on users. Repeated use of cocaine can cause life-long damage, physically altering the brain's structure.
Cocaine may be extracted from the leaves of the coca plant or created synthetically. In the past cocaine was used as a medical treatment for various conditions ranging from depression to a cough. In addition to being a stimulant, cocaine can have a numbing effect. It is still used in some countries under controlled conditions as a anesthetic.
The United States categorizes cocaine as a Schedule II drug. It is illegal for use except for legitimate medical purposes. As an illegal drug, cocaine is available in several different forms including powder and crystals. Street names for cocaine include crack, snow, powder, and blow.
WorkplaceTesting Explains Cocaine
The U.S. Department of Transportation (DOT) includes cocaine and its metabolites in the set of 5 drugs for which mandatory drug testing is required for safety sensitive employees. The drug is usually included in non-DOT testing as well. Cocaine causes the user to experience euphoria and may become addictive after just a few uses. Use of cocaine not only affects the users behavior and brain function, but can also cause severe damage to the circulatory system leading to heart failure or death.
Signs of cocaine use include dilated pupils, sleeplessness, paranoia, euphoria, excitability, and loss of appetite. Additionally, cocaine users may suffer headaches, confusion, nausea, and seizures, among other adverse effects.
Undergoing treatment for cocaine addiction is a multi-step process and will include a period of psychological and physical withdrawal.
Crack, Snow, Powder, Blow
Department of Transportation Test
Prohibited Controlled Substances
Coke Bugs
Drug TestingUrine TestingOral Fluid TestingPre-work Evaluations

redpajama_set_name: RedPajamaCommonCrawl


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Drafts and sketches for the digitally printed glazing vinyl artwork for the ground floor Radiotherapy Unit of the Robert White Cancer Centre are now in progress in the studio. At this stage, the drafts are for comment and discussion and the final design work will be tailored in response to this process.
Draft Artwork for the Radiotherapy Unit of the Robert White Cancer Centre, Dorchester. Image: Christopher Tipping
Inspired by Jurassic plant fossils, such as Cycads, Tree Ferns, Magnolias, Monkey Puzzle and Gingko, the ideas are developing by way of a distinct colour palette and abstract pattern-making too, as well as looking to incorporate and blend in with the glazing artworks of the Outpatient Unit on the first floor, which were completed late in December 2018. Although the two floors deliver independent services via Poole Hospital and Dorset County Hospitals, it is important that from the outside particularly, the artwork links the two floors and presents a united front elevation to all those visiting & working on this site. The Jurassic Coast and the Abbotsbury Sub-Tropical Gardens, have both been influential. The coastal geology has been a particular fascination, with stones and fossils being very much the theme of the first floor Outpatients department.
Site images and plans for the ground floor Radiotherapy Unit of the Robert White Cancer Centre, Dorchester. Image: Christopher Tipping
Draft Artwork for the Radiotherapy Unit of the Robert White Cancer Centre, Dorchester. Artwork & Image: Christopher Tipping
Draft Artwork Sketchbook for the Radiotherapy Unit of the Robert White Cancer Centre, Dorchester. Artwork & Image: Christopher Tipping
Seen in a new light…a bronze dog & a surgeon's leg
Hospital Streets Project at Dorset County Hospital completed 2009. Tarkett vinyl flooring with bespoke inlaid motifs with assorted hospital legs. Image: Christopher Tipping 2019
Above: Bespoke inlaid flooring with a Surgeon's leg.
I have worked at Dorset County Hospital on two previous occasions, both memorable. My association with the Trust and its Arts in Hospital Team goes back to 1993, some 26 years! This recent visit to start a new project for the Radiotherapy Unit at the recently completed Robert White Centre, was quite poignant, because I made a concerted effort, whilst there to re-connect and revisit two commissions I had previously created for the Hospital, in 1993 and 2009 respectively. I have deliberately not looked back at the files for these projects, in fact I am not sure I still have the 1993 project on record. That was definitely pre-digital.
Interesting to see things again – unplanned and in the moment and experience them anew.
The Dog Courtyard at Dorset County Hospital 1993. Bronze Dog by Dame Elisabeth Frink. Courtyard Landscape by Christopher Tipping
The Dog Courtyard at Dorset County Hospital seen through rain spattered windows on a bad weather day. I couldn't access the courtyard directly yesterday due to the weather. The bronze dog is by Dame Elisabeth Frink, who I was extremely privileged to meet at her home in Blandford Forum in 1992, when I was taken there by my commissioner Val Pitt-Rivers, the founder of Arts in Hospital and a great friend of Elisabeth's. Elisabeth Frink died in 1993. The courtyard was designed and created around this beautiful sculpture and was loosely based upon a roman villa garden.
'In 1987, the Vice Chairman of the hospital, Val Pitt-Rivers, started Arts in Hospital with the help of a few friends. Since her retirement in 1998 she has continued to support us as an active patron. Her first committee was responsible for some of our most iconic artworks such as the Red & Blue Crayons by Peter Logan and the Dog by Dame Elisabeth Frink, a founder patron of Arts in Hospital.
After the opening of Phase 1 of the new Dorset County Hospital in 1987, the internal courtyards became the main focus of the arts project. The first to be completed was the Waterfall Courtyard by the sculptor Hamish Horsley. Soon after followed the courtyard to house Elisabeth Frink's Dog, which was designed by artist Christopher Tipping, and then the Bird Garden designed by John Hubbard with stone fragments engraved by Richard Grasby'. Arts in Hospital
I love to see the lichens growing everywhere…a sign of age…as well as the Box and Bamboo topiary, maintained as cubes as per the original design.
The Hospital Streets project was completed in 2009 & was commissioned by the then director of Arts in Hospital, Alexandra Coulter.
The project was focussed on colour and wayfinding over three floors of the hospital, with the inspiration coming from two days spent walking & exploring along the Jurassic Coast and another day buried deep in the archives of the Dorset County Museum fossil collections. We collaborated with Tarkett flooring and created bespoke motifs which were inlaid at key points along the Hospital Streets such as lift lobbies and stairs. The work is now almost 10 years old and still looks remarkably fresh considering the heavy traffic.
Hospital Streets Project at Dorset County Hospital completed 2009. Tarkett vinyl flooring with bespoke inlaid motifs & assorted hospital legs. Image: Christopher Tipping 2019
Hospital Streets Project at Dorset County Hospital completed 2009. Tarkett vinyl flooring with bespoke inlaid motifs. Image: Christopher Tipping 2019
Hospital Streets Project at Dorset County Hospital completed 2009. Tarkett vinyl flooring with bespoke inlaid motifs & assorted belemnites by the Chapel entrance. Image: Christopher Tipping 2019
Hospital Streets Project at Dorset County Hospital completed 2009. Tarkett vinyl flooring with bespoke inlaid motifs & assorted found objects. Image: Christopher Tipping 2019
Hospital Streets Project at Dorset County Hospital completed 2009. Tarkett vinyl flooring with bespoke inlaid motifs & assorted hospital legs & trolleys. Image: Christopher Tipping 2019
Hospital Streets Project at Dorset County Hospital completed 2009. Tarkett vinyl flooring with bespoke inlaid motifs & hospital beds. Image: Christopher Tipping 2019
Hospital Streets Project at Dorset County Hospital completed 2009. Tarkett vinyl flooring with bespoke inlaid motifs & fossil sea urchin. Image: Christopher Tipping 2019
Hospital Streets Project at Dorset County Hospital completed 2009. Tarkett vinyl flooring with bespoke inlaid motifs with fossil sea urchin & yellow truck. Image: Christopher Tipping 2019
Hospital Streets Project at Dorset County Hospital completed 2009. Tarkett vinyl flooring with bespoke inlaid motifs & an obliging hospital porter. Image: Christopher Tipping 2019
The Robert White Centre
Haematology Outpatients at the Robert White Centre, Dorset County Hospital. Image: Christopher Tipping.
I spent Monday & Tuesday of this week in Dorchester at the new £9million Robert White Centre, based at Dorchester County Hospital. This building was part funded via a legacy from Robert White a Poole based businessman, who was treated for cancer at the Dorset Cancer Centre at Poole Hospital. Robert died in 2015.
"Proceeds from the sale of this incredible collection will be used to build new cancer facilities at Poole and Dorset County hospitals, benefiting patients across the whole of the country."
"Robert White was a great man and an enthusiast of all things mechanical. The sale is a showcase of his life's passion, with more than 500 lots set to raise more than £2 million for charity," said Malcolm Barber, Bonhams Co-Chairman. "The collection is the result of a life's passion for photography – Robert was the founder of one of the UK's leading photographic retailers – and his adoration for motorcycles. We're delighted to be able to offer this for sale, and for such a great charitable cause."
"The money raised from the Robert White Collection will help to fund essential improvements in cancer diagnosis and treatment in Dorset, including:
– New cancer treatment radiotherapy facilities at Dorset County Hospital to benefit patients in the west of the county, meaning shorter travel times
– New computerised tomography (CT) scanner for Poole Hospital, accurately identifying cancer site to enable targeted treatment
– Permanent positron emission tomography (PET) scanner at Poole Hospital – a sophisticated imaging technique widely used for cancer, providing highly detailed imagery showing tumours and its response to treatment.
– Education and training bursaries to enable staff working in cancer care and associated medical and diagnostic specialties to remain at the cutting edge of best practice".
Bonhams 2016
I was there to begin some engagement with staff and patients in the ground floor Radiotherapy Unit, which is a satellite of the Dorset Cancer Centre at Poole Hospital.
I was very kindly shown around by Amanda Sydenham, Macmillan Prescribing and Review Radiographer/Treatment floor Superintendent, and introduced to other staff members. We were accompanied by Nikki Mitchenere, Deputy General Manager – Oncology Legacy Fund at the Dorset Cancer Centre, who has commissioned me for this work.
I am now starting to work up some draft ideas and proposals. These will be circulated throughout the unit so we can get feedback from everyone. The important thing is that we do this in a collaborative and engaged manner.
Obviously, whilst there I took a quick look upstairs to see how the artwork in Outpatients was being received by everyone. I was re-assured after talking to a couple of staff members there, that this seems to be a great success. The artworks for Radiotherapy, will build upon this established colour base and iconography, adding in some new motifs and objects. It is important that the work on both floors appears to have a relationship, with elements interwoven between both floors.
A slightly blurred and abstract image taken from outside, of the first floor windows reflecting surrounding trees & a street light mixed up with the artwork. The weather was atrocious all day, with rain and high winds – not the best backdrop.
These digitally printed glazing artworks, commissioned by Arts in Hospital for the first floor Haematology Outpatients unit were installed in December 2018, just prior to the official opening of the Robert White Centre.
This unit is managed and operated by Dorset County Hospital.
We had a wonderful endorsement for the art project from Patricia Miller, Chief Executive of DCH.
'I really love this. It creates such a pleasant therapeutic environment that also links to Dorset's natural surroundings. Thank you for working so hard to create such a pleasant environment for our patients.'
The Robert White Centre, Dorset Cancer Centre
Blog, Cancer Unit Dorset County Hospital, Healthcare Projects, Public Art, Public Realm
My digitally printed artworks for the new Robert White Centre were partially installed in December 2018, just prior to the official opening of the building on December 12th. The first floor glazing has now been completed in the Cancer & Haematology Outpatients Department on the first floor. This is the Haematology Outpatients department and the services are delivered by Dorset County Hospital. The artwork for the ground floor Radiotherapy Cancer Unit is now in progress. Services here are being delivered by Poole Hospital. The new Cancer Centre is an extension of the Poole Hospital-based Dorset Cancer Centre.
The Robert White Centre, Dorset County Hospital. Artwork Image: Christopher Tipping. Photographer: Adrian Holbrook
The Robert White Centre, Dorset County Hospital. Artwork Image: Christopher Tipping. Photographer: Alex Murdin
"The £9 million centre is an extension of the Poole Hospital-based Dorset Cancer Centre. The Dorchester unit is equipped with the latest linear accelerator (LINAC) which enables patients to receive the best-possible radiotherapy treatment. This means that cancer patients in the north, south and west of the county can receive this care in their local hospital, instead of having to travel to Poole for treatment.
The facility also includes a £1.75 million Cancer and Haematology Outpatients Department funded by the Cancer Appeal run by Dorset County Hospital Charity. This was supported by hundreds of donations from individuals, community groups as well as Trusts and Foundations.
This building has been funded in part by an extraordinarily generous legacy from Poole businessman Robert White. Robert White was treated for cancer at the Dorset Cancer Centre, part of Poole Hospital, and sadly lost his battle in November 2015. Before his death, he had resolved to support the hospital and its county-wide cancer services to benefit others and decided that he would fund a new cancer unit, now named The Robert White Centre.
Martin Clunes said: "It was my privilege to be able to officially open the new Robert White Centre.
"The incredibly generous support from the community for the DCH Cancer Appeal, as well as Robert's generosity, leaves a remarkable legacy for patients with cancer in Dorset." Poole Hospital NHS Foundation Trust 2018
Precious Objects
Blog, Cancer Unit Dorset County Hospital, Healthcare Projects
Draft Artwork & Motifs for Glazing Vinyl Dorset County Hospital. Image: Christopher Tipping
Some years ago a long standing family friend and close friend of my Dad was being treated for cancer. He and his wife had often been to Elgol on the shores of Lock Skavaig on the Isle of Skye. They loved this place. I too had been there and as is the case – and now slightly frowned upon – I picked up some stones from a stream bed. The stones were small, but smooth & beautifully polished to a honed satin finish by the action of water. They could be held in the hand and moved around. The feeling of them was somehow special and resonant. I still have them now, wrapped in a cloth bag for fear of damaging them. I sent one of these stones to Dad's friend. In doing that I think we had a non verbal conversation at distance about place and memories. I like to think it was re-assuring for both of us.
I have always picked up stones. They represent something unique about place, time and experience. Geology is fascinating.
I live by the sea in Ramsgate on the Kent Coast. I walk on the beach most days. I have found many sea urchin fossils. Each has a unique story. Each stone can still trigger memories of where and when it was found, what the weather was like…was the tide in or out.
I have created work for several projects with Cancer treatment centres at a number of Hospitals, including Churchill Hospital Cancer Centre, Oxford and a Macmillan Cancer unit for Tameside General Hospital. At Tameside Hospital and found my inspiration on a 12 mile walk entitled "Journeys through the Landscapes of Tameside" – this walk eventually became the brief for the project.
Stewart Ramsden, my walking partner who compiled the walk, had also been a cancer patient at the hospital and was part of our project's champion group. Our route was eventually described by an eccentric figure of eight. Wild Bank and Hollingworthall Moor from Godley – a 12 mile walk through town, suburb, farmland and moorland.
The following words were made from my notes on the day:
This is a walk
A meander, a physical experience or just maybe a day-dream
A walk is more often along a path
The path or footpath changes in colour, texture and topography –
but there is always a remembered route to follow or a map to guide you
or maybe a venture to somewhere new
There is a constancy in moving forward
Things seen on a walk are half experienced and half remembered
A vivid green hedge
A tyre track
A discarded toy
A cloud which looks like a tree, a stream which looks like silver, a flash of colour
Horizon merges with sky
This is a landscape with no fixed perspective
Sky reflected in water
A small stone becomes a boulder
An object picked up and carried in the hand along the way
Track marks in fields are gestural and dynamic
Distant buildings become a child's building blocks
The layersPatterns in brickwork
Our project for the new Radiotherapy Unit at Dorset Hospital was similarly inspired by a walk along the Jurassic Coast I made ten years ago. I was hoping to find myself an ammonite to take home. I didn't find any, but I saw many encased in rock by the shore. I saw the Blue Lias beds that contain giant plesiosaur fossils. The layers are like drawers in time. Each opening to another world and perhaps another wonder. I was also allowed free time to spend in the Dorset Museum Archives amongst boxes and drawers and piles of specimen stones and fossils. The way these objects were carefully curated and stored – often in intricate patterns and collections of similar sizes and or type. was inspiring and reminded me of my collections at home and of how precious they are to me. The artwork has grown out of this fascination. The stones I have created are imaginary in colour and pattern, although informed by nature. They are perhaps stones I would like to find. Stones I would hold in my imagination to remind me of journeys I have made and places I have been.
We have now had the approval and sign off on the artwork proposals following a recent meeting with key Staff and stakeholders this week. The deadline is looming. The new building opens on 12th December. The work has to be manufactured and installed before this date.
Draft Artworks for Glazing Vinyl Dorset County Hospital. Image: Christopher Tipping
To create the digital work each element requires up to 3 copies of each shape. One blank, one black & white and one in colour. The black & white originals are a mix of hand drawn motifs and textures, which are then scanned and worked on in Photoshop. I create a series of related shapes and masks, which I can then combine with larger patterns, often in repeat.Colours are added at this stage. I will often scan objects such as found paper or leaves and work on them digitally. I take too many images in the street, of shapes of water on the pavement – or reflections in windows – or a small plant growing in a crack in the ground or on a wall. All these can trigger an idea for a pattern or story.
First Floor Reception Artwork for Glazing Vinyl Dorset County Hospital. Image: Christopher Tipping
Golden yellow Ginkgo sapling motif for Glazing Vinyl Dorset County Hospital. Image: Christopher Tipping
First Floor Non Clinical Staff Room. Artwork for Glazing Vinyl Dorset County Hospital. Image: Christopher Tipping
Agate Stone colour motif for Glazing Vinyl Dorset County Hospital. Image: Christopher Tipping
Window 101 Artwork for Glazing Vinyl at Dorset County Hospital new Radiotherapy Unit. Image: Christopher Tipping
Autumnal sapling tree motif for Glazing Vinyl Dorset County Hospital. Image: Christopher Tipping


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MICHAEL WILDES JOINS FOX5 REGARDING THE OPIOID EPIDIMIC
Managing Partner Michael Wildes, a Former Federal Prosecutor and Mayor, joins Fox5 to discuss the funneling of opioids to distributors and the ongoing federal litigation. April 2019.
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Wildes & Weinberg is a boutique law firm specializing exclusively in the practice of U.S. immigration and nationality law and was founded in 1960 by Senior Partner Leon Wildes, whose best-known accomplishment was his successful representation of John Lennon in his widely publicized deportation proceedings, the circumstances of which have inspired several films, books, and documentaries.
Today the firm, which has offices in New York City, Englewood, New Jersey, Miami, Florida, and by appointment in Los Angeles, California, services a distinguished domestic and international clientele and covers all areas of U.S. immigration law, including employment and investment-based immigration, work permits, permanent residence for qualified individuals, family-based immigration, asylum applications and all temporary and permanent type visas.
In addition to running a highly successful immigration law practice, Michael is also of counsel to Lincoln Center for the Performing Arts and two international/corporate law firms. A former Federal Prosecutor with the United States Attorney's Office in Brooklyn (1989-1993), Michael has testified on Capitol Hill in connection with anti-terrorism legislation, and is a frequent participant on professional panels and commentator on network television and radio with regard to US immigration law, employer sanction work and compliance.
Michael, the author of Safe Haven in America: Battles to Open the Golden Door, was recently sworn in for a third term as Mayor of Englewood, New Jersey, was appointed to the District Appeals Board of the Selective Service System for the State of New Jersey, was a member of the New Jersey Governor's Blue Panel on Immigration, and has been a guest lecturer at many distinguished forums and institutions including Yale University, New York University, Brooklyn Law School, and The Benjamin N. Cardozo School of Law, where Michael is an Adjunct Professor of Business Immigration Law.
Despite difficulties currently being encountered in dealing with U.S. immigration authorities, Wildes & Weinberg has maintained an extraordinary track record for success for its cases. Moreover, the firm's multilingual staff is known for its experience and special expertise in processing each foreign national's case with nothing less than the highest level of professionalism.
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Elected each year by the players, this committee consists of representatives of each of the major sections of the orchestra (violins, lower strings, woodwinds, brass). The committee meets monthly with the manager to communicate player concerns to the board and conductor, and to receive information about board decisions and activities.
Whenever possible an orchestra member will assume the task of librarian for the orchestra and will receive a monthly honorarium for this job. The librarian is responsible for cataloguing, marking, distribution and collection of scores and parts for the music the orchestra plays, as well as looking after its condition, and replacing lost or damaged parts. Most of the music we play is owned by the GVYO, while some is rented or borrowed from other orchestras. The orchestra also lends music to a number of musical organizations around the island.
The Stage Manager is responsible for organizing the set-up and take-down of the orchestra, before and after all rehearsals and performances.
The Youth Orchestra engages GVYO members as requiring C.A.P.P. credit for Grade 12 as Student Assistants, to teach them the skills involved in orchestra administration.


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Home All News Miss Hmong Laos Contest to Be Held in December
Miss Hmong Laos Contest to Be Held in December
Latsamy Phonevilay
Contestants are flocking to enter the fourth annual Miss Hmong Laos contest, which will be held in December this year.
The Miss Hmong Laos contest includes various performances to demonstrate the identity and culture of the Hmong ethnic group, in order to spotlight their cultural heritage in Laos and on the international stage.
Director of Lao Trading and Mineral Processing Co. Ltd, and president of the Miss Hmong Laos Contest, Mr. Thongvilay Lidthideth, says that the purpose of the Miss Hmong Laos contest is to provide an opportunity for Hmong youth to participate in positive activities.
"Furthermore, it is also a way for talented young Hmong people to demonstrate their abilities," says Mr. Thongvilay.
The contest has developed over the years, and 2020 will see a much larger event than previous years.
Applications remain open to all Lao Hmong around the country from 24 November 2019, with the final contest to run from 27 December 2019 to 5 January 2020.
Miss Hmong
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Latsamy Phonevilay graduated from the Dongdok University Faculty of Letters and has begun a career as freelance journalist.


The Plein Jeu tracker organ is part of The New Franck Organ Range that we launched for sale in 2014.
The Plein Jeu is designed to stand in an arch, for instance, with its taller central tower. The revolutionary specification deals with the requirements of all musical circumstances and the organ has a price tag worth enquiring about before contacting our digital organ competitors.
Please look at the New Range page for further details.
I come from a musical family, and we played Bach virtually every evening, playing on the organ, singing cantatas - Bach was almost a family illness!


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NC teen creates 'ear savers' for healthcare workers fighting virus
(WLOS)
By: WSOCTV.com News Staff
Updated: April 29, 2020 - 8:22 AM
ASHEVILLE, N.C. — A North Carolina high school sophomore is putting his robotics skills to good use to help fight COVID-19.
>> Have questions about the coronavirus pandemic and its impact on the Carolinas? We have an entire section dedicated to coverage of the outbreak -- CLICK HERE FOR MORE.
Corbin Duncan told our news partner WLOS he is using a 3D printer to make "Ear Savers" for healthcare workers. These are important because the face masks nurses and other healthcare workers wear can be uncomfortable on their ears.
Duncan made them in Asheville, North Carolina, but he saw an article about a Canadian boy scout doing the same thing and knew he could do it too.
Duncan said it was his obligation to step up and help during this time.
"I know the doctors of our community work so hard and they are working harder than ever to help the people of the United States," Duncan said. "And, I feel like it's just kind of my job to pitch in when I can and make their lives easier."
He said he and his robotics team have already given away 500 "Ear Savers." They can make around 50 new pairs each day.
VIDEO: A simple way to make a face mask by anchor Susanna Black
>> We'll bring you LIVE updates on Channel 9 Eyewitness News. Get extended coverage on the free WSOC Now app on Roku, Amazon Fire and Apple TV.


"Kensington: in need of revitalization."
Located between North Philadelphia and the Lower Northeast, Kensington is an older Philadelphia neighborhood offering very low rent prices – primarily because it is not a desirable area to live in.
The population is a mix of Caucasians, Hispanics and African Americans. Typical Philadelphia row homes line the streets, but many are in poor condition or abandoned. A handful of homeowners frequently attempt to revitalize the area and keep their blocks clean; unfortunately most do not, which contributes to the unkempt appearance of the neighborhood.
SEPTA services the area via the Market-Frankford Line and numerous bus routes; however it is not a place you wish to walk alone at night. Crime rates are extremely high, and the corner of Kensington Avenue and Somerset Street has been listed as one of the top recreational drug corners in the city.
Overall, Kensington is in need of major revitalization and gentrification, which has not yet reached the area. If low real estate prices are what you seek, there are many other areas that are safer, accessible and have better schools, all at comparable costs.
"Kensington: The good, the bad and the ugly."
Mention that you even need to drive through Kensington and people cringe and ask if you're going alone. This area is really run down with the houses and really dirty in general. The schools are really bad too. I had applied to their highschool because it looked good on the brochure and as an honor student, they even urged me to go elsewhere. There is a lot of crime going down there and a lot of theft. The restaurants are nice I guess, but they sure aren't worth living here for.
tnt123 "Mention that you even need to drive through Kensington and people cringe and ask if you're going alone. This area is really run down with the houses and really dirty in general. The schools are really bad too. I had applied to their highschool because it looked good on the brochure and as an honor student, they even urged me to go elsewhere. There is a lot of crime going down there and a lot of theft. The restaurants are nice I guess, but they sure aren't worth living here for. "
You are absolutely right, and it seems to just keep getting worse and not better.
Having lived in Kensington for a year, I grew to know this neighborhood fairly well. While it's not the nicest or the safest neighborhood in the city (hard to find one of those!) Kensington definitely has its perks. A relatively small neighborhood, Kensington is tightly packed between Northern Liberties, Fishtown and Port Richmond.
If you're moving to this area, stay close to Fishtown and Northern Liberties, as these are the nicer and safer streets. Be cautious at night walking alone, and absolutely never leave car doors or house doors unlocked. If you're aware of your surroundings, you'll be ok.
Because properties are so inexpensive in this area, there seems to be an influx of remodels and new, eco-friendly buildings popping up left and right. This makes for an interesting dynamic with older row homes standing next to super modern, newly built townhouses. This area is great for renters, who can find affordable townhouses or great industrial loft apartments for much less than in Center City. Getting into the city is quite easy from Kensington with the El running right downtown with three stops along Front Street in Kensington.
The nightlife and restaurant scene continues to grow, and residents of this neighborhood are loyal patrons to certain spots. Bigger named chefs are realizing this area is up-and-coming as well, with names like Stephen Starr moving in on Frankford Avenue.
Kensington is one of those neighbors when you hear its name you think "I am not going." Once, a major part of the textile industry the neighborhood is now considered one of the poorest. Today many of the buildings are abandoned or just in terrible shape.
Illegal activity is the only thing that ever stands out about Kensington. If there is a positive nightlife I have to hear about it. Sadly, there seems to be more reason to move out of Kensington than there is to move to Kensington. I wish I could say something good about the neighborhood but every time I have been there I have left as quickly as possible.
"Watch out for unscrupulous landlords"
"Now a revolting little street"
"Not in a good area of town"
What's the best restaurant in Kensington?


There is no single reading program or method that will address all the needs of struggling readers, because each learner has his or her own unique strengths and weaknesses. In fact, there are many cognitive processing weaknesses that can effect young learners and if you want quick and optimal results, it's important to pursue a comprehensive evaluation. A good assessment will help uncover the areas of difficulty. Then educational professionals, such as an experienced reading specialist or educational therapist can focus on strengthening those specific areas of cognition.
What Are Some of The Cognitive Processing Areas That Impact Reading?
Tracking: is the ability of the eyes to follow the movement of an object in motion or follow words across the page from left to right.
Visual Synthesis – is the ability to pull the pieces together to create a visual whole.
Visual Closure - is the ability to identify or recognize a symbol or object when the entire object is not visible.
Visual Discrimination - is the ability to discriminate between visible likeness and differences in size, shape, pattern, form, position, and color.
Visual Reasoning - is the ability to understand and analyze visual information.
Visual Memory - is the ability to recall what has been seen.
Visual Sequencing - is the ability to recall the sequence of symbols, letters or numbers that have been seen.
Attention to Visual Details - is the ability to attend to and recognize all the information and fine points presented in an image.
Auditory Discrimination - is the ability to detect differences in sounds.
Auditory Memory - is the ability to remember the details of what is heard.
Auditory Sequencing - is the ability to remember the order of information in which it was heard.
Auditory Closure - is the ability to "fill in the gaps" and decipher a word or message when a part is distorted or missing.
Sound Symbol Association - is the ability to connect a sound with a symbol or letter.
Word Retrieval - is the ability to rapidly and precisely express ideas into specific words.
Receptive Language - is the ability to accurately understand language that is seen or heard.
Mental Flexibility - is the ability to shift our thoughts in order to respond effectively to any given situation.
Comprehensive Reading Programs Work, But Are They The Best Solution?
No one would suggest a whole body workout, if you just had a weak bicep. Although a whole body workout would help in many ways, it will be a long process and your bicep may never receive the intensive work it needs to catch up with the rest of your body. Likewise, a reading program is always beneficial, but it will probably take time and it may never strengthen the specific cognitive areas that need the most attention.
To strengthen specific areas of cognition, it is important to do repeated activities that exercise those areas of the brain. For example, if you need to improve a student's tracking abilities, he or she would need to do a lot of activities that would require their eyes to follow from left to right and follow objects in motion. Likewise, to improve visual discrimination, a student would need to complete a lot of activities that would require the processing of similar images. They would need to learn to practice and uncover likenesses and differences.
What Are Some Specific Tools Professionals, Teachers and Parents Can Use?
To help make this process easier, I have designed a series of specific cognitive activities and games in a series of publications called Reversing Reversals. The first publication in the Series, Reversing Reversal Primary, offers cognitive training materials for young learners that are struggling with letters and numbers, as well as those that are showing signs of dyslexia or other learning disabilities. This product includes fun activities and games that use animals which will truly please and entice students. Young learners will not even realize that they are working on the foundational skills that are necessary to learn basic math and reading. The next product is Reversing Reversals Beginners and Reversing Reversals. This integrates letters and numbers into the activities and games. Finally, Reversing Reversals 2 continues to offer more activities which work with letters, numbers and even symbols. Other options include my Following Directions Series, Executive Functioning Games, and Working Memory Series. Free samplings of the activities are also available on the product pages.


Find autos & automotive services in Ainsworth, IA. Listings include AMC Restorations of Iowa and Sweeting Tools. Click on each in the list below the map for more information.
Thank you AMC 60 years later their Metro hoods still being used as sleds.


Because the early 1960s, a compelling body of proof has accumulated showing that proteinases play critical tasks in airspace enlargement in chronic obstructive pulmonary disease (COPD). relationships between different classes of proteinases, and between proteinases and additional substances that amplify lung swelling and damage. This review will talk about the biology of proteinases as A-443654 well as the mechanisms where they donate to the pathogenesis of COPD. Furthermore, I'll discuss the potential of proteinase inhibitors and anti-inflammatory medicines as fresh treatment approaches for COPD individuals. which regularly colonizes the respiratory system of COPD individuals, PMN necrosis is definitely quickly induced (Naylor et al 2007). Many of these procedures hinder non-inflammatory macrophage removal of PMN, rather advertising PMN necrosis and launch of proteinases in to the lung. Quantum proteolysis and PiZZ 1-PI insufficiency NE exists at millimolar concentrations in each azurophil granule A-443654 of PMN, which is definitely a lot more than 100-collapse greater than the focus of 1-PI in plasma (Liou and Campbell 1995). The discharge of the azurophil granule in to the extracellular space is definitely thus along with a transient burst of proteolytic activity (Number 4), which persists before granule material diffuse out of this site, as A-443654 well as the proteinase-inhibitor percentage falls below 1:1 (Liou and Campbell 1995). People with serious, inherited scarcity of 1-PI possess serious reductions in plasma degrees of 1-PI (significantly less than 4 M in PiZZ 1-PI lacking people versus ~30 M in healthful PiMM people) because of loop sheet polymerization of PiZ mutant proteins within hepatocytes, resulting in decreased hepatocyte secretion of PiZ 1-PI (Lomas et al 1992). Quantum bursts of NE-mediated proteolytic activity connected with PMN migrating on ECM protein are 10-fold bigger in region and 4-fold much longer in duration when PMN are bathed in serum from PiZZ sufferers in comparison to serum from healthful PiMM topics (Campbell et al 1999), because of faulty confinement of PMN-derived NE-mediated ECM degradation. Various other mechanisms resulting in excessive ECM devastation and lung irritation in sufferers with serious, inherited scarcity of 1-PI are the development of polymers of PiZ 1-PI mutant protein in the lung, which not merely are inadequate inhibitors of NE, but likewise have chemotactic activity for PMN (Mahadeva et al 2005; Lomas 2006). Prospect of proteinase inhibition in COPD Based on the available proof, strategies to straight inhibit proteinases or even to reduce the lung proteinase burden by lowering inflammatory cell influx in to the lung could be effective in restricting proteinase-induced lung damage in COPD sufferers. Direct proteinase inhibition Supplementation with physiologic proteinase inhibitors This plan works well in murine types of COPD and in individual topics with COPD supplementary to 1-PI insufficiency. Delivering 1-PI systemically or with the inhaled path to smoke-exposed mice inhibits smoke-induced lung irritation and airspace enhancement (Churg et al 2003b; Pemberton et al 2006). Alpha1-PI enhancement therapy has been utilized in the united states in 1-PI-deficient sufferers who've impaired lung function. Observational research using this plan concur that it decreases bronchial irritation, slows the speed of drop in lung function, boosts quality-of-life ratings, and reduces exacerbation rate of recurrence in 1-PI-deficient individuals (Stockley et al 2002a; Juvelekian and Stoller 2004). Artificial proteinase inhibitors Artificial inhibitors A-443654 possess many advantages over physiologic inhibitors, including their level of resistance to oxidative and proteolytic inactivation and their performance against both soluble and membrane-bound types of proteinases (Owen et al 1995b, 2003, 2004). In pets exposed to tobacco smoke, or in transgenic mice over-expressing IL-13, providing man made inhibitors of serine, metallo-, and cysteine proteinases from the systemic, dental, or inhaled routes blocks lung swelling and airspace enhancement (Churg et al 2002; Lanone et al 2002; Stockley et al 2002b; Wright et al 2002; Pemberton et al 2005). Daily dental delivery of artificial MMP inhibitors not merely helps prevent airspace enhancement in mice chronically subjected to tobacco smoke, but also helps prevent development of lung swelling and airspace enhancement if therapy is set up after emphysema continues to be founded (Martin et al 2001). Artificial inhibitors could also possess potential in restricting the airflow blockage produced by little airway fibrosis, Rabbit polyclonal to AFF2 since a artificial substance that inhibits both MMP-9 and MMP-12 efficiently blocks little airway fibrosis in cigarette smoke-exposed guinea pigs (Churg et al 2007a). Anti-inflammatory strategies Methods to reducing inflammatory cell recruitment in to the lung and activation of inflammatory cells wouldn't normally only decrease the lung burden of inflammatory cell-derived proteinases but also that of additional pathogenetic substances generated by inflammatory cells in COPD individuals such as for example ROS and pro-inflammatory mediators. Inhibitors of phosphodiesterase E4 (PDE4), the main PDE isoenzyme in inflammatory cells, reduce inflammatory cell migration, activation, and launch of proteinases in vitro. Roflumilast (a PDE4 inhibitor) also protects mice from cigarette-smoke induced lung swelling and.
Mice teaching mosaic manifestation of an appropriate marker gene that is activated during development provide simple tools for investigating cell lineages. in adults. The stability of the adult stripe pattern suggests that stem cell function is usually unchanged between 8 and 52 weeks. transgene Introduction The mammalian endocrine adrenal gland is usually composed of two different tissues with unique developmental origins: the mesoderm-derived outer steroidogenic cortex and the neuroectoderm-derived chromaffin cells of the inner medulla, which produce catecholamines and neuropeptides. The adult adrenal cortex is usually surrounded by a mesenchymal tablet and subdivided into three principal concentric biochemically and morphologically unique zones of steroid-synthesizing cells. The outer zona glomerulosa (ZG) synthesizes the mineralocorticoid aldosterone; the EKB-569 middle zona fasciculata (ZF) produces the glucocorticoid cortisol (corticosterone in mice and rats), and the inner zona reticularis (ZR) bordering the medulla makes C19 steroids, the so-called adrenal androgens in humans and some primates, though not in rats and mice. In common with other species, the three principal adult mouse adrenocortical zones each display a characteristic morphological cellular arrangement, although zonal boundaries can sometimes be indistinct, EKB-569 and their thickness, particularly of the ZR, varies considerably between EKB-569 different mouse stresses.1C3 The small basophilic cells of the IL5R ZG have little cytoplasm and are arranged in globular arched-like structures. Eosinophilic cells of the ZF contain abundant cytoplasmic lipid droplets, the substrate for steroid hormone synthesis, and are arranged in columns. Cells of the ZR retain some lipid but display a characteristically compacted morphology. Early studies recognized a morphologically unique zona intermedia (ZI) in the rat adrenal cortex, located at the junction between the ZG and ZF.4,5 Subsequently, this zone was shown to be short of manifestation of the terminal steroidogenic enzymes 11-hydroxylase (Cyp11b1) and aldosterone synthase (Cyp11b2) and has therefore been termed the undifferentiated zone (ZU).5C7 In mouse, however, the presence of a ZU has yet to be reliably demonstrated. Development of the murine adrenal gland has been well-described in recommendations 3 and 8C15 and progresses through the following stages: (1) formation of an adrenogenital primordium from a group of condensing coelomic epithelial cells conveying the important steroidogenic transcription factor SF-1 (mouse embryonic days 8.5C9.5; At the8.5CE9.5); (2) dorso-medial separation of unique adrenal and gonadal primordia (mouse At the10.5CAt the11.5); (3) commencement of fetal adrenal growth and manifestation of SF-1-dependent adrenal-specific steroidogenic enzymes, at the.g., steroid 21-hydroxylase, Cyp21a1 (mouse At the11.5CAt the12.5); (4) migration of neural crest cells into the developing adrenal gland to form the medulla (mouse At the12.5CAt the13.0); (5) adrenal tablet formation from mesenchymal cells (mouse At the13.5CAt the16.5); (6) growth of the fetal cortex from inner fetal cortical progenitors and initiation of the conclusive (adult) cortex from peripherally located fetal cortical progenitor cells, which give rise to a unique adult lineage from around At the14.5; (7) resolution of the three conclusive adrenocortical zones (late gestation from around At the16.5 onwards in mice); (8) formation of the relatively short-lived Times zone from the fetal zone adjacent to the medulla (from mouse postnatal day 10; P10); (9) degeneration of the Times zone (at puberty in male mice, during the first pregnancy in females and later in virgin females); (10) normal physiological function of the adrenal cortex from early adulthood at around P40C50. Though currently less well-defined for the mouse, the adult rat adrenal cortex is usually managed by a balance of cell proliferation in the outer cortex, centripetal displacement of cells16,17 and cell death in the ZR close to the medulla boundary.10,18,19 Nevertheless, it is still not clear whether (1) the adult adrenocortical zones are managed by independent proliferation of cells within a zone, (2) the ZG and ZF/ZR are managed.
Cancerous brain tumors are among the most lethal cancers, and conventional therapies are largely limited to palliation. for cancer stem cells are preferentially sensitive to an inhibitor of Fingolimod Akt, a prominent cell survival and invasion signaling node. Treatment with an Akt inhibitor more potently reduced the numbers of viable brain cancer stem cells relative to matched non-stem cancer cells associated with a preferential induction of apoptosis and a suppression of neurosphere formation. Akt inhibition also reduced the motility and invasiveness of all tumor cells but had a greater Fingolimod impact on cancer stem cell behaviors. Furthermore, inhibition of Akt activity in cancer stem cells increased survival of immunocompromised mice bearing human glioma xenografts conversion of grade III anaplastic astrocytoma to grade IV glioblastoma16-21. Because of the association of Akt activity with a wide range of tumorigenic properties, we hypothesized that brain cancer stem cells may exhibit a dependence on the Akt pathway. Indeed, chemoresistance in hepatocarcinoma stem cells may be conferred by activation of Akt11 and Akt manages the success of growth cells in the perivascular market bearing come cell guns in mouse medulloblastoma versions21. To further check out the dependence of mind tumor come cells on Akt signaling, we pharmacologically treated combined populations of glioblastoma tumor come cells and non-stem cells with a little molecule inhibitor of Akt. We wanted to determine if preferential focusing on of mind growth come cells could become accomplished through inhibition of Akt by reducing the capability of these cells to survive, proliferate, and invade, reducing their particular cancerous potential therefore. Strategies and Components Remoteness of Compact disc133+ and Compact disc133? growth cells Capital t3359 ethnicities were isolated from major glioblastoma examples amplified in immunocompromised rodents transiently. Growth individuals had been acquired Fingolimod from medical Rabbit polyclonal to ZNF320 biopsies of consenting individuals under a process authorized by the Duke College or university Medical Middle Institutional Review Panel. G456MG xenografts had been originally extracted from a pediatric glioblastoma biopsy example of beauty and possess taken care of in immunocompromised rodents under a Duke Institutional Pet Treatment and Make use of approved protocol. Of note, T3359 and D456MG express wildtype PTEN. Tumors were dissociated into single cells using an enzyme dissociation kit (Worthington Biochemical, Lakewood, NJ). For fluorescence-activated cell sorting (FACS) into CD133+ and CD133? enriched populations, cells were labeled with an allophycocyanin-conjugated CD133 antibody (Miltenyi Biotec, Auburn, CA) before sorting by FACS. For magnetic bead sorting (MACS) into CD133+ and CD133? enriched cell populations, cells were incubated with CD133 antibodies conjugated with biotin and magnetic beads that bind biotin prior to separation by a magnetic column (Miltenyi Biotec, Auburn, CA). CD133+ cells were maintained in their undifferentiated state using Neurobasal Media supplemented with epidermal growth factor and fibroblastic growth factor Fingolimod (each at 10 g/500 mL media), sodium pyruvate, glutamine, B27, non-essential amino acids and penicillin/streptomycin (Gibco, Grand Island, NY). CD133? cells were maintained in their differentiated state with Dulbecco's Modified Eagle Medium (DMEM, Gibco, Grand Island, NY) supplemented with 10% fetal bovine serum (FBS, Sigma-Aldrich, St. Louis, MO) and penicillin/streptomycin. Small Molecule Inhibitor The small molecule inhibitors of Akt (AktIII/SH-6, AktII), PI3K (LY294002), and mTOR (rapamycin) were bought from Calbiochem (San Diego, California). For all assays, share solutions developed by dissolving the medication in dimethyl sulfoxide (DMSO, Sigma-Aldrich, St. Louis, MO) had been kept at ?80C. Prior to the test Instantly, share solutions had been diluted in DMSO to 1000x of the last concentrations indicated. Fingolimod For each test, 1 D/mL of DMSO as a control or inhibitor 1000x share solutions in DMSO had been added to the press of cells to make the indicated last concentrations of inhibitor. Traditional western and Antibodies Blotting Compact disc133+ and Compact disc133? cells had been plated in suitable press in six-well china at 5105 cells per well and allowed to recover over night. Compact disc133? press was transformed to Compact disc133+ development press before each test for the indicated moments. All cells had been collected collectively and after that lysed in stream (62.5 mM Tris-HCl, 2% w/v sodium dodecyl sulfate (SDS), 10% glycerol, 40 mM dithiothreitol (DTT) and protease inhibitors). Proteins concentrations had been quantified (Biorad Proteins.
Lentiviruses infect many cell types and are right now widely used for gene delivery subscriber base of these foreign vectors by macrophages is a constraint. by phagocytes of an surrounded trojan is normally mediated in component, in naive serum even, by opsonins such as immunoglobulin and suit that can content or physisorb to lentivectors during creation in lifestyle and postinjection.6C10 Acute or chronic inflammatory replies initiated by vector elements can take place after uptake,11,12 and antibodies that end result from adaptive immunity improve viral uptake Fc receptors often, 13C16 which are restricted to phagocytes generally. Decrease of virus-like measurement by the natural resistant program provides as a result been tried by change with artificial polymers17 similar to stealth films on liposomes that hold off deposit of opsonizing serum protein which get distance (assess uptake by phagocytic cells and by nonphagocytic cells. NOD/SCID/Il2rg?/? (NSG) mice are then used to assess whether hCD47-Lenti display enhanced blood flow and gene delivery to lung malignancy xenografts as NSG mice communicate a unique mouse variant of mSIRPA that binds human-CD47 (ref. 33) in contrast to additional murine SIRPA versions that do not bind to human being CD47 with similar affinity.34 NSG mice lack practical lymphocytes,35 but have practical macrophages36 so that the NSG model allows the focused study of macrophages in lentiviral vector clearance. On the additional hand, SIRPA offers very long been reported to become indicated on cells additional than immune system cells,27 and we discover here that targetable SIRPA is definitely indicated at low levels on human being lung malignancy produced epithelial cells. Focusing on of SIRPA could therefore become useful for gene therapy of lung carcinoma,37,38 maybe actually with systemic delivery that accesses multiple sites of disease. Since Marker of Self inhibition of liver distance is definitely less obvious from past studies than splenic distance, and because the liver is definitely a desired target for appearance of transgenes such as coagulation factors,39 we try to clarify results on Kupffer cells also, which are SB 203580 the principal liver organ macrophages.40 Five independent experimental results and with human or mouse macrophages demonstrate HEK 293T cells (Figure 1f). Viral presenting assays possess been utilized to interrogate trojan cell interactions previously.53,54 The mCD47-Lenti was used in these experiments to distinguish lentivector presented Compact disc47 aside from any endogenous individual Compact disc47 present on DFNB39 HEK cells. Stream cytometry was utilized to SB 203580 assess mCD47 and GFP screen on the individual HEK cells, and indicated the transfer of the mCD47-GFP blend proteins to the cell surface area. This is normally constant with the capability of the Compact disc47-Lenti getting capable to screen after that transfer Compact disc47 to the surface area of a focus on cell. Sucrose gradient ultracentrifugation of Compact disc47-Lenti supernatants should enrich for the fairly thick capsid-containing virions from entire supernatants that also include lighter cell particles, vesicles, and mass media elements55 (Supplementary Amount Beds3a). Such a break up was verified by an SB 203580 assay for useful titer of contagious trojan in HEK 293T cells (Supplementary Amount Beds3c, c), SDS Web page (salt dodecyl sulfate polyacrylamide serum electrophoresis) evaluation for virus-like capsid protein (p24) and serum albumin, as well as immunoblot analysis for CD47-GFP (anti-GFP (Supplementary Number T3m) were performed. The virally delivered transgene in these and all studies below unless normally indicated is definitely a CMV-promoter driven reddish fluorescent protein (RFP) variant DsRed.MST,56,57 which allows for fluorescence quantitation of transduced cell figures. Importantly gradient layers comprising practical disease experienced both CD47-GFP and p24 (Supplementary Number T3elizabeth), while practical titer correlated over a ~500-fold range with p24 levels (Supplementary Number T3n). CD47 inhibition of macrophage transduction To provide an model of a brief Lenti exposure as analyzed later on, macrophage transduction by hCD47-Lenti versus control Lenti was assessed by illness (Number 2a) of human-derived, PMA-differentiated THP-1 cells for just 1 hour. However, the lentivector to cell percentage (illness in just 1 hour is definitely consequently expected to require at least 72-collapse more disease (increased by polybrenes impact) and is normally also relevant to receptor-mediated an infection unlike the regular MOI assay using.
A true number of different studies have shown that neurotrophins, including nerve growth factor (NGF) support the survival of retinal ganglion neurons during a variety if insults. passed down RP (RP) suggesting the main features of the individual disease is certainly the 564483-18-7 IC50 Noble University of Cosmetic surgeon (RCS) rat. The visible pathogenesis of this rodent strain comprises a group of 564483-18-7 IC50 passed down modern retinal cell dystrophies characterized by fishing rod and cone photoreceptor deterioration, leading to modern reduction of eyesight [2,3]. This eyesight pathology impacts around 1 in 400 in a general inhabitants and presently a resolute therapy that can criminal arrest or considerably enhance the result of the disease is certainly not really obtainable [4,5]. Hence, any pets versions of RP with equivalent hereditary failures, either taking place normally or attained through transgenic manipulations that can offer additional details and enable to recognize brand-new systems and ideally recommend potential healing strategies represent a main purpose of many professional in this field of ocular disorder. The RCS rat is certainly a well-known hereditary pet model of photoreceptor deterioration to check out this factor, including the id of natural mediator included in mechanism of cell death and cell survival. During last few decades, fields of interest of these experimental methods, include the use of drugs delivery  transplantation of retinal pigment epithelium (RPE) or photoreceptors [7C10], gene therapy , the administration of growth factors . The first evidence of possible neuroprotective effect of growth factor on retinal cell degeneration was reported by [12,13] who exhibited that beta-fibroblast growth factor might be able to safeguard degenerating photoreceptors in RCS rats . Regrettably, it was also found that this growth factor causes retinal neovascularization making unacceptable for further studies and potential human therapy . More recently, it was reported that retina of mice and rats affected with RP are characterized by reduced presence of Nerve Growth Factor (NGF) and NGF-receptors and suggested that exogenous NGF administration might delay and/or protect photoreceptors degeneration [15C18]. Other studies supporting the hypothesis that NGF is usually involved in the protection of retinal cells were provided by Siliprandi et al in rat  Carmignoto et al in rabbit , and in glaucoma by Lambiase and Aloe in rats and humans . Nerve growth factor (NGF) is usually the first uncovered and the greatest characterized member of the neurotrophin family members  that contains Brain-Derived Neurotrophic Aspect (BDNF) and Neurotrophin-3/4/5 [23,24]. The natural impact of NGF is certainly mediated by two distinctive receptors: trkANGFR (a tyrosine kinase receptors) and g75NTR and the natural activity on focus on cells is dependent on their surface area trkANGFR/g75NTR proportion [25,26]. Intracerebral administration of filtered NGF provides been proven to protect basal forebrain cholinergic neurons that are known to degenerate in human brain maturing and storage reduction in lab pets [27,28] and in Alzheimers disease . The neuroprotective function of NGF was furthermore recommended by our research displaying that in vivo NGF administration protects degenerating retinal ganglion cells and photoreceptors deterioration [18,21,30] that lead the speculation that exogenous intra-vitreal or topical cream NGF administration might end up being capable to recovery degenerating retinal cells. Nevertheless, apparent evidence that Tcfec NGF acts in degenerating photoreceptors is certainly even now not obtainable directly. Whether photoreceptors of mice developing RP exhibit trkANGFR 564483-18-7 IC50 and NGF actions is certainly described or mediated by regional retinal cells possess been not really however set up, staying an open up issue. The herein defined in experiments were designed to investigate the direct role of NGF on isolated and cultured photoreceptors. Materials and Methods Ethics Statement and Animals A total of 96 RCS animals at postnatal day 10 (p10) were housed at the CNR animal facility and dealt with according to the experimental process approved by the Ethical Commission rate on animal experimentation of the National Research Council (CNR, Rome). All experiments were conducted in accordance with the guidelines for the use of animals stated by the Association for Research in Vision and Ophthalmic Research. All efforts were.


At United Rentals, we offer a seamless and supportive transition for recent graduates from academics to their professional careers. As a Fortune 500 company, we're able to offer strong earning potential shortly after graduation. New Grads tend to start in either a Sales Associate role in one of our 1,000+ branches or at one of our Sales Development Program Centers in Charlotte or Phoenix. Starting in these positions will lead to opportunities as an Outside Sales Representative. We teach and mentor on the best ways to sell and provide solutions for customers, as well as about our product advantages and differentiating features.
Upon program completion, you will have the opportunity to become an Outside Sales Representative in one of our 1,000+ locations.
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I did not expect to learn about so many different aspects of the company. This internship always stayed exciting, as I was constantly learning new and different things about United Rentals.
The internship program exceeded my expectations in many ways. I didn't expect to travel so much to other branches and local jobsites, but that was my favorite part of the program, as well as ride-alongs with the truck drivers.
I thought that the company went above and beyond to improve my experience as an intern.
I gained a lot of knowledge within sales that I can take with me wherever I go. I also learned a lot about United Rentals and feel comfortable having this as a job option after college.
This was more than just a summer job because everyone that I met helped me develop as a professional and a person. Learning across operations, sales and management, I was able to appreciate and understand each aspect of the company.
My favorite part about the internship is that each day was different and exciting. I assisted inside and outside sales reps and worked closely with my branch manager on leads and quotes for potential big jobs. I learned so much and have become passionate about the industry.