HOOMD-blue is the first general purpose MD code built from the ground up for GPU acceleration, and has been actively developed since March 2007. It supports a variety of force fields and integrators targeted at soft-matter simulations. As an open source project, numerous developers have contributed useful feature additions back to the main code. High performance is the first design priority in HOOMD-blue development. Over the years, we have rewritten core computation kernels several times to obtain the best possible performance on each GPU hardware generation. Ease of use is the second priority. Python job scripts allow users to easily configure and control their simulations. Good object-oriented software engineering practices ensure that HOOMD-blue's code is easy to extend, both for the users and developers. Extensive validation tests show that HOOMD-blue produces correct results.


Rue Magazine features The Novogratz and their new Hollywood Hills home. Read the rest of the issue here.
Los Angeles Times features a Thanksgiving Tablescape designed by The Novogratz. See all of the photos here.
InStyle covers the Novogratzes' new book, Beachside Bohemian. Read the article here.
Home Accents Today covers the partnership between Momeni Rugs and The Novogratz. Read the article here.
Houstonia interviews Bob and Cortney about creating a boutique lifestyle and the new book, Beachside Bohemian. Read the article here.


On Tuesday, the teachers of the Soufriere Comprehensive Secondary School were in for a treat. Annually, the first week of October is observed as teachers appreciation week, and the students at the learning institution paid homage to the faculty on the eve of world teachers day.
The St. Lucia teachers' union will hold a toned-down celebration of Teachers Week 2017. The annual observance commenced with educators participating in fellowship and worship with the usual supplication and benediction at special service on the weekend.
CIBC first Caribbean International Bank hosted its annual "walk for a cure' on Monday, October 2nd in Rodney Bay and Vieux-Fort. Proceeds from the activity will be donated to support the St. Lucia cancer society and faces of cancer.
The sustainable development ministry hosted a public awareness campaign at the Sir Arthur Lewis Community College in observance of international ozone day. Students were educated on refrigerators and air conditioning, ozone depleting substances and the importance of fire safety in the home and Work-place.
What Does Trade Licence Reform Mean For Saint Lucia?
National unemployment has remained above 20% for the first half of 2017. Data from the central statistics department indicate fewer jobs were gained in the second quarter.


Please note that course curriculum and live cases / surgeries covered are assured. Although the order and scheduled times of live cases / surgeries might change depending on the final course schedule and participants number.
© Copyright Cosmedica. All Rights Reserved.


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The Plight Of Dei-Dei Land Owners
IGHO OYOYO
One of the challenges facing Abuja residents is how to develop their land to become house owners in the Federal Capital Territory (FCT). IGHO OYOYO writes on the plight of residents of Dei-Dei community in their efforts to own their own houses.
The desire of every Nigerian, residing in the Federal Capital Territory (FCT) is to become house owners one day. This is even pertinent in the present harsh economic situation, where landlords increase house rents, without considering the plight of the people. But, when land owners buy plots, with documentations to show and still face daunting hurdles in developing them, it becomes a thing of great concerns for the government to look into.
Sometimes, residents tend to wonder which is easier in the nation's capital, to rent an apartment or buy land and build. Either way, Abuja residents are finding it very tough, even though those who choose to build their own houses seem to be gnashing their teeth.
This is the case of some landowners in Dei-Dei community in Abuja Municipal Area Council (AMAC), who claimed that they bought land in Dei-Dei since 1999, but could not develop them, because the immediate past minister of the Federal Capital Territory (FCT), Senator Bala Mohammed relocated their plots to new developers. Chairman of Zaudan Pazeri Property Owners Association, Elder Friday Ugoala, told LEADERSHIP that the land owners were allocated some plots in 1998 and 1999, through an ad-hoc committee and that all the land owners complied with all the processes and fees demanded by the administration.
According to Ugoala, their plots were also recertified under the Mallam Nasir El-rufai administration and that the Abuja Geographic Information System (AGIS) acknowledged that their documents were being processed, adding however that the authorities had denied them Certificate of Occupancy (C-of-O) and refused to approve their building plans, a development he said, crippled their efforts.
"In 1998 the government identified that the major problem of accommodation is what is affecting the Federal Capital Territory (FCT) and that there was not enough accommodation for government workers, not to talk of private residents.
So, the government then, came up to address this major problem by mapping out a layout in Zauda, Pazeri and Fillindabo and other layouts. The government then gave out over 3,000 plots in the layouts in Zauda Paziri and Fillindabo within Dei-Dei district.
These plots were allocated to Nigerians from all walks of life, because the housing deficit knew no bound, which ranged from civil servants, uniform men, traders, judiciary, religious organisations and corporate bodies amongst others that benefitted from the allocation. The layouts had ministerial approval and upon the allocation, files were opened and the necessary bills, which included survey, ground rates and certificate of occupancy, which were paid for and files opened.
He continued: "Unfortunately, no approval for building plans was given, until a former minister of FCT, Mallam Nasir El-rufai came on board and called for the recertification of the allocations, which we all responded and paid the fees for recertification and new files were opened at AGIS and we complied with the necessary things that were demanded from us," he said.
He explained further that it was the last they heard of it, adding that rather than processing their Certificate of Occupancy and given approval to some of them that had the drawings of their building plans, activities within the two layouts came to a halt.
"So, during the last administration of President Goodluck Jonathan, the next thing we heard was that the layouts were redesigned and super imposed on phase 4 of the FCT Master plan, without considering those that were allocated plots of land in the same environment. The most painful aspect is that the layout was given to mass housing developers, without the innocent Nigerians who were originally given the plots of land and had complied with all the requirements.
"The truth is that the plots were not revoked, while this was done and if they revoked, that means it did not follow due process, because you cannot revoke land from private and reallocate to private. If there were issues of public interest, it would have been different, but it was not so. We are begging the FCT Minister, Malam Mohammed Bello to order a reversal to what was on the ground; Zaudan Pazeri and Filindabo layouts have received ministerial approval and they are authentic layouts. So, anything on the contrary, means injustice," he said.
Another affected landowner, Mr. Friday Mba, who is also the financial secretary of the association, lamented that the land owners have been going through serious emotional trauma since the land issue started with the FCTA, because they purchased the plots of land with their hard-earned money from the businesses they do.
"We bought the land with every necessary paper and all the money demanded were paid and they were well documented at AGIS. We are appealing to the FCT Minister to come to our rescue, because we are really suffering. Presently, most of us can hardly eat or sleep well, because of this land problem with the FCTA. We have been going through serious emotional trauma, as a result of this land matter and some of our members are dead. President Buhari should come to our rescue," he said.
Mba explained that the affected land owners cut across profession, both rich and poor, also the indigenes of Zaudan, Pazerri, Sabon Gari and Filindabo villages that own farms of cash crops and economic trees.
"Because when the government considered that they do not have cash to settle them for their cash crops and farm produce that are involved in the layout, they were then compensated with plots according to sizes of their farms and the numbers of cash crops and tress that were involved.
I believed that if there is an allocation, the position of the law that I have knowledge of, is that before the property allocated to somebody is taking over from the person, the person that allocated it will say he wants to withdraw the allocation he made to the occupant, and before he could do that, it must be for public interest, but in this case, it was not so."
However, efforts made by LEADERSHIP to get the position of the FCT administration on the matter proved abortive, as the head of information, department of land administration of the administration, Sule Hazat, could not be reached. Also, several calls and text messages, to his phone were not replied.
Related Topics:Federal capital territory (FCT)
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NSCDC Arrests 3 Cable Vandals In Abuja
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Abuja Nigeria's Fourth Largest City – NPC Abuja Nigeria's Fourth Largest City – NPC
Education Secretariat Laments Vandalisation Of School Properties
Plant More Trees, Save The Earth
Maina Calls For Support To Science, Technology Development

redpajama_set_name: RedPajamaCommonCrawl


One of the most challenging things to deal with in life is figuring out what you are going to do with it. What is your "purpose"? This page and the corresponding blog posts will serve to provide information and maybe some tips and tricks to find your calling, or how to find something in life that you enjoy.


The entire family is in for the adventure of a lifetime.
Beaches Negril's Pirates Island, an 18,000 square foot waterpark along the ocean's edge. Kids of all ages will be laughing, splashing and having the time of their lives!


Jose Mourinho has confirmed that he expects Zlatan Ibrahimovic to leave Manchester United at the end of the season.
Ibrahimovic's contract at Old Trafford expires this summer and the Swedish striker has made just seven first-team appearances this season after recovering from a knee ligament injury.
The 36-year-old has been strongly linked with a move to long-term suitors LA Galaxy, with United unlikely to offer him another contract extension.
"We all think it's his last season at Manchester United and it will be a very personal decision for him to play or to stop," said Mourinho.
"I think he wants the right of choosing his life, his future, such an amazing player and amazing career. [It's a shame] that only that awful injury at the wrong moment broke a fantastic couple of seasons he could, and should, have had with us. This season is really different for him.
"He's not injured. Does he feel totally happy, ready and convinced that he's in condition to help the team in this moment? No. But he's such an honest guy and such a champion, he only wants to be back with that feeling of 'I'm totally ready for it'.


Hi, Katie — Thank you for visiting my blog and subscribing. Congratulations on all of your writing success. I look forward to the day when I can show off a novel of my own!
Patti that is awesome!! Thank you so much for nominating my blog 🙂 I'm glad I could inspire you. I'll be sure to repost a little later today!


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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay
Justin Hall, Pfizer
Douglas T. Golenbock, University of Massachusetts Medical SchoolFollow
Eicke Latz, University of Massachusetts Medical SchoolFollow
Department of Medicine, Division of Infectious Diseases and Immunology
Enzymes and Coenzymes | Immune System Diseases | Immunity | Immunoprophylaxis and Therapy
Cyclic GMP-AMP synthase (cGAS) initiates the innate immune system in response to cytosolic dsDNA. After binding and activation from dsDNA, cGAS uses ATP and GTP to synthesize 2', 3' -cGAMP (cGAMP), a cyclic dinucleotide second messenger with mixed 2'-5' and 3'-5' phosphodiester bonds. Inappropriate stimulation of cGAS has been implicated in autoimmune disease such as systemic lupus erythematosus, thus inhibition of cGAS may be of therapeutic benefit in some diseases; however, the size and polarity of the cGAS active site makes it a challenging target for the development of conventional substrate-competitive inhibitors. We report here the development of a high affinity (KD = 200 nM) inhibitor from a low affinity fragment hit with supporting biochemical and structural data showing these molecules bind to the cGAS active site. We also report a new high throughput cGAS fluorescence polarization (FP)-based assay to enable the rapid identification and optimization of cGAS inhibitors. This FP assay uses Cy5-labelled cGAMP in combination with a novel high affinity monoclonal antibody that specifically recognizes cGAMP with no cross reactivity to cAMP, cGMP, ATP, or GTP. Given its role in the innate immune response, cGAS is a promising therapeutic target for autoinflammatory disease. Our results demonstrate its druggability, provide a high affinity tool compound, and establish a high throughput assay for the identification of next generation cGAS inhibitors.
Copyright: © 2017 Hall et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843. eCollection 2017. Link to article on publisher's site
Full author list omitted for brevity. For the full list of authors, see article.
Hall, Justin; Golenbock, Douglas T.; and Latz, Eicke, "Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay" (2017). Open Access Articles. 3270.
Enzymes and Coenzymes Commons, Immune System Diseases Commons, Immunity Commons, Immunoprophylaxis and Therapy Commons


"3 Dishes + 1 Soup"
If you were to watch Channel 8's variety show, you would probably be familiar with this show called 《三菜一汤》? Basically, the guest artists of the week will have to compete to cook up a "3dishes+1soup" within a given period of time.
So how do you like my simple, homey "3dishes+1soup" dinner?
A recent survey shows that 80% of Singaporeans prefer to eat at home than dining out.
However, not everyone is confident enough to cook or even have the time to cook.
This is when Lee Kum Kee's ready-made sauces, menu-oriented sauces, come in handy! All it takes is only 30 minutes (tested and proven) to cook up a scrumptious 4-course meal at home!
1. Bring the pot of water to boil. Add in the vegetables of choice and hot pot ingredients.
2. When the soup boils again, lower the heat and allow it to simmer for 10 minutes.
4. Crack in an egg and let it simmer for another minute before serving.
This is my favourite type of soup to cook whenever I'm pressing for time! It can never get boring because of the versatility of the soup. Basically it's a mini hot pot anytime! Just play around with the different types of ingredients to use, and a packet of Lee Kum Kee Soup Base for Black Pepper and Pork Bone Hot Pot would really last you a good time!
Hope you would like this simple recipe that I've just shared. The rest of the 3 dishes would be coming up next. Stay tune and remember to 'like + share' my photo tagged with #leekumkeemos #injust30minutes on Instagram and Facebook ya?


Opened in 2001 by Craig and Vicki Leuthold, family-owned Maryhill Winery is one of Washington's largest wineries, producing 80,000 cases annually. Perched on a bluff and nestled among rows of vines along the stunning Columbia River in Goldendale, Washington, it is a popular destination for travelers and wine enthusiasts alike. Visitors can enjoy wine tastings, live music on the vine-covered terrace every summer weekend, Memorial Day through September, tours and special events, tournament-quality bocce courts, and a world-class summer concert series in its adjacent 4,000-seat outdoor amphitheater. Maryhill's 3,000 sq. ft. tasting room and 1,200 sq. ft. Reserve Room draw more than 75,000 wine enthusiasts from around the globe each year, ranking among the top-five most visited wineries in the state. Maryhill sources more than 30 unique varietals of grapes from some of the most highly regarded vineyards in Washington, and produces more than 50 wines. Maryhill Winery has been honored with more than 3,000 awards since its first vintage in 2001, including being named 2015 Pacific Northwest Winery of the Year by Wine Press Northwest and the 2014 Winery of the Year at the San Francisco International Wine Competition.


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Edda Adler de Graschinsky (Los Toldos, 9 de agosto de 1937-Buenos Aires, 31 de julio de 2019) fue una química y bióloga argentina, especializada en neurotransmisores y fisiopatología cardiovascular. Se desempeñó como investigadora superior del Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina(CONICET) en el Instituto de Investigaciones Farmacológicas (ININFA).

A lo largo de su carrera, Adler fue galardonada con el Premio Bernardo Houssay en 1992, y con un Diploma al Mérito Konex en Bioquímica y Microbiología en 2003.

Biografía
Nacida en la localidad bonaerense de Los Toldos el 9 de agosto de 1937, Edda Adler inició sus estudios universitarios en la Facultad de Ciencias Exactas y Naturales de la Universidad de Buenos Aires en 1955, recibiéndose de licenciada en química en 1960; en 1961 inició su doctorado en química, graduándose en 1964 con su tesis titulada Poder antibiótico de cepas de Streptomyces aisladas de muestras de tierra de la República Argentina.

Es investigadora superior del CONICET desde 1974, desempeñándose en el Instituto de Investigaciones Farmacológicas, del cual fue directora ejecutiva entre 1991 y 2003; además, entre 1997 y 1998 ocupó el cargo de gerente del CONICET. El trabajo de Adler se enfoca en el estudio de los factores y mecanismos que regulan la liberación de neurotransmisores, y el rol que cumplen los endocanabinoides en la fisiopatología cardiovascular.

En 1985, Adler participó como miembro invitado de la fundación del Serotonin Club, perteneciente a la Clínica Mayo de Rochester, Estados Unidos; en 1986 ingresó a la Comisión Asesora de Ciencias Médicas y luego, en 1987, intervino como jurado en los Premios Nacionales, evaluando en las disciplinas de biología general, zoología y botánica. El Centro de Estudios para el Desarrollo de la Industria Químico - Farmacéutica Argentina (Cediquifa) le otorgó el Premio Bernardo Houssay de Farmacología en 1992, año en el que intervino como jurado en Premio Estímulo a la Investigación Científica, entregado por la Facultad de Farmacia y Bioquímica de la Universidad de Buenos Aires; en 1996 actuó nuevamente como jurado en los Premios Nacionales, evaluando las mismas disciplinas. Dos años después, en 1998, fue nombrada presidente de la Asociación Argentina de Farmacología Experimental.

En 2001, integró el Comité de Selección de las Becas de Investigación Ramón Carrillo - Arturo Oñativia, del Ministerio de Salud Pública de la Nación Argentina y, al año siguiente, la Comisión Asesora de Ciencias de la Salud de la Universidad de Buenos Aires. En el 2003 recibe un Diploma al Mérito en Bioquímica y Microbiología, en el marco de los Premios Konex de aquel año. Es nombrada presidenta de la Comisión Asesora de Ciencias Médicas en 2004; formaba parte de dicho organismo desde 1995 y se desempeñaba como su vicepresidente desde 2003. En 2005, Adler fue nombrada como coordinadora del grupo de análisis de los Premios Houssay, en el área de ciencias biológicas y de la salud. Además, ha ocupado el cargo de investigador superior en distintos organismos, entre los que se destacan la Fundación Alberto Roemmers (1995 - 1997), la Fundación Antorchass (1997 - 2000), el Ministerio de Salud Pública de la Nación Argentina (2000 - 2002) y el Fondo para la Investigación Científica y Tecnológica (desde el 2000 en adelante). Ha publicado trabajos en revistas especializados, varias de ellas de circulación internacional; de hecho, entre 1965 y 2005 ha publicado sesenta y seis artículos en dichas revistas.

Premios
 Premio Bernardo Houssay: Farmacología (1992).
 Premios Konex: Diploma al Mérito - Bioquímica y Microbiología (2003).

Referencias

Químicos de Argentina
Biólogos de Argentina
Investigadores del CONICET
Toldenses
Alumnado de la Facultad de Ciencias Exactas y Naturales de la Universidad de Buenos Aires
Argentinas del siglo XX
Argentinas del siglo XXI
Biólogas de Argentina
Premios Bernardo Houssay
Diplomas al mérito Konex
Fallecidos en Buenos Aires

redpajama_set_name: RedPajamaWikipedia


text:
The return of the abject: a psychoanalytic analysis of a selection of William Shakespeare's plays in the light of Julia Kristeva's theories of the mind
2018-11-22T10:20:59Z (GMT) by Amir Mahmoudzadeh-Andwari
The present research deals with the application of Julia Kristeva s psychoanalytic theories of the mind to a selection of William Shakespeare s plays. Kristeva s key psychoanalytic terms the symbolic, the semiotic and the abject are first elaborated in detail and are then applied to different situations and characters in the plays. The plays discussed in this thesis are A Midsummer Night s Dream, As You Like It and The Taming of the Shrew for the comedy section, Richard II, 1 & 2 Henry IV and Coriolanus for the English and Roman History section, and Romeo and Juliet, Macbeth and King Lear for the Tragedy section. The reason for choosing the above plays is that I believe there is a gap of knowledge in this regard and no thorough research on this scale has been conducted up to this time. The intention is to discuss and explicate the moments in which the dramatic heroes undergo some unconscious-driven experiences that can be best explained by Kristeva s post-Freudian psychoanalytic approach. In short, what I am going to show in the present study is the psychoanalytic assumption that Shakespearean characters, forced by internal or external elements, leave the symbolic and take refuge in the semiotic. In such moments, the characters inevitably face the abject which is an archaic memory comprising the elements of enchantment and horror. The abject can be best described as the archaic memories of a distant past when the self had no border and was associated with the semiotic, a subject s harmonious beginning. In its early childhood, to become a subject, an individual breaks its semiotic ties and, by so doing, enters the realm of the symbolic which is associated with grammar and law. The symbolic awards a subject a distinct identity and helps it stay on the route to signification. Kristeva s understanding of the process of individuation is explained by her subject in process , a journey in which a subject always oscillates between the symbolic and the semiotic. The key point in Kristeva s psychoanalytic thought is that the semiotic does not fade away and hovers around a subject s border of identity and remains a constant threat for its symbolic identity. To remain immune from the annihilating forces of the semiotic, a subject has to remain vigilant and protect its borders of identity. My main goal in this thesis is to show that, in some particular situations in the plays, Shakespearean characters fail to remain vigilant and, inevitably, their subjects are exposed to the abject. In other words, in moments of ambition, anger, love or fear, they surrender or take refuge in the semiotic and face the abject. Although Shakespearean plays have previously been approached by Sigmund Freud s (and some other major practitioners ) theories, the application of Kristeva s psychoanalytic theories of the mind gives the opportunity to approach the plays from a new perspective that would otherwise have remained unknown. Thus, the originality of this research lies in its extensive application of Kristeva s theories to the selected Shakespearean plays, theories that, although they derive from those of Freud, have the potential to shed light on those psychoanalytic aspects of the plays that Freud either neglected or left unfinished.
Studies in the Creative Arts and Writing not elsewhere classified
Symbolic, The Semiotic, The Abject, The Subject-in-process Shakespeare, William Kristeva, Julia


text:
x-radio
Matti Turunen *Live*
Old analogue synths and drum machines, and cheesy low quality 80's digital effects are some of the basic components for Matti's music. With styles from early Chicago and Detroit to sublime futuristic electronic funk, it will always be a surprise what Matti comes up with on his machines.
Abstract Forms
AC Records
Detroit techno
Electronic funk
Muhk
ProForm Series
Ojis
Ojis started to make electronic music back in 1996 with Fast Tracker 2. After a couple of bad mistakes he decided it's better to let other people to do that job. He lived a few years just partying all around until he bought his first pair of Technics SL-1200 turntables.
When it comes to deejaying, Ojis doesn't mix smoothly or do fancy tricks with the mixer. He concentrates on reading his audience and building up an intimate atmosphere. Mostly Ojis plays music from deep house to Detroit techno and acid.
Janne Puurunen, also known as DJ Burdock, was born in 1976. In the late 80's he discovered electronic music and started collecting hip hop records. Very soon after that he was introduced to underground warehouse parties in the Turku area. In 1993 together with a few of his friends he started an organization called The X-Rust Organization, whose main function was to promote underground electronic music. The same organization is still up and running releasing records, arranging parties and giving opportunities to new talent.
Acid Symphony Orchestra
LilPorridge
X-Rust
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