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Volleybox Statisticians Ukraine
Pavlo Sidenko
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Veterans with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have a markedly increased rate of second malignancy, which is the most common cause of death
Mouhammed J Kyasa, Linda Hazlett, Rudolph S Parrish, Steven A Schichman, Clive S Zent
Leukemia & Lymphoma 2004, 45 (3): 507-13
Patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) have an increased incidence of high-grade lymphoid malignancy. The risk of non-lymphoid second malignancy in this population is not well-defined to date. To test the hypothesis that patients with CLL/SLL have an increased risk of second malignancy, we studied the rate of second malignancy in 132 CLL/SLL patients and compared it to the rate of malignancy (excluding non-melanomatous skin cancer) in the Central Arkansas Veterans Healthcare System population of approximately 38,000 veterans over a period of 11.5 years. The rate of second malignancy, diagnosed concomitantly or after CLL/SLL, and the age-adjusted rate of malignancy calculated from tumor registry reports and demographic data, were used to calculate a Standardized Morbidity Ratio (SMR) with 95% confidence interval (CI). Twenty-one (16%) of the CLL/SLL patients had second malignancies (19 non-lymphoid, 1 Richter's transformation and 1 Hodgkin's disease), which were fatal in 15 (71%) patients. The SMR for the CLL/SLL population was 2.97 (95% CI 1.84-4.55) for second malignancy and 2.69 (95% CI 1.62-4.21) for non-lymphoid second malignancy. This study of a well-defined CLL/SLL population shows a significantly increased risk of second malignancy, which was the primary cause of death for 9% of all CLL/SLL patients (34% of all patient deaths).
Second malignancy risks after non-Hodgkin's lymphoma and chronic lymphocytic leukemia: differences by lymphoma subtype. Lindsay M Morton, Rochelle E Curtis, Martha S Linet, Elizabeth C Bluhm, Margaret A Tucker, Neil Caporaso, Lynn A G Ries, Joseph F Fraumeni Journal of Clinical Oncology 2010 November 20, 28 (33): 4935-44
Autoimmune cytopenia does not predict poor prognosis in chronic lymphocytic leukemia/small lymphocytic lymphoma. Mouhammed J Kyasa, Rudolph S Parrish, Steven A Schichman, Clive S Zent American Journal of Hematology 2003, 74 (1): 1-8
Other malignancies in chronic lymphocytic leukemia/small lymphocytic lymphoma. Apostolia-Maria Tsimberidou, Sijin Wen, Peter McLaughlin, Susan O'Brien, William G Wierda, Susan Lerner, Sara Strom, Emil J Freireich, L Jeffrey Medeiros, Hagop M Kantarjian, Michael J Keating Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology 2009 February 20, 27 (6): 904-10
Second neoplasms in patients with chronic lymphocytic leukemia. Peter H Wiernik Current Treatment Options in Oncology 2004, 5 (3): 215-23
The clinical course of lung carcinoma in patients with chronic lymphocytic leukemia. K Parekh, V Rusch, M Kris Cancer 1999 November 1, 86 (9): 1720-3
Second cancers in patients with chronic lymphocytic leukemia. L B Travis, R E Curtis, B F Hankey, J F Fraumeni Journal of the National Cancer Institute 1992 September 16, 84 (18): 1422-7
Chronic lymphocytic leukaemia and small lymphocytic lymphoma: overview of the descriptive epidemiology. Graça M Dores, William F Anderson, Rochelle E Curtis, Ola Landgren, Evgenia Ostroumova, Elizabeth C Bluhm, Charles S Rabkin, Susan S Devesa, Martha S Linet British Journal of Haematology 2007, 139 (5): 809-19
Diagnosis and prognosis of B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma (B-CLL/SLL) and mantle cell lymphoma (MCL). Nancy Yousef Asaad, Moshira Mohamed Abd El-Wahed, Marwa Mohammed Dawoud Journal of the Egyptian National Cancer Institute 2005, 17 (4): 279-90
Hodgkin transformation of chronic lymphocytic leukemia: the M. D. Anderson Cancer Center experience. Apostolia-Maria Tsimberidou, Susan O'Brien, Hagop M Kantarjian, Charles Koller, Fredrick B Hagemeister, Luis Fayad, Susan Lerner, Carlos E Bueso-Ramos, Michael J Keating Cancer 2006 September 15, 107 (6): 1294-302
Second cancer incidence and cancer mortality among chronic lymphocytic leukaemia patients: a population-based study. J A Royle, P D Baade, D Joske, J Girschik, L Fritschi British Journal of Cancer 2011 September 27, 105 (7): 1076-81

redpajama_set_name: RedPajamaCommonCrawl


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Farmville-Like App Wants People To Put Their Phones Down
Eric Jou
Published 6 years ago: December 23, 2014 at 7:30 am -
Filed to:android
appschinafarmville
Focus; it's apparently what old people say young people lack these days. Well in China, a new mobile app seeks to use public humiliation as a means to help its users focus better. Oh, did I mention that this app was also a game?
The app, aptly named "Focus (专心)" has been making the rounds online in China since its debut earlier this month. The premise is simple: turn on the app, and for however long you leave the app and your phone untouched, you grow a plant. The plant grows larger the longer you don't touch your device. Sounds familiar? Well that's because the premise is similar to the focus app Forest.
Where Focus deviates from Forest is its "gaming" elements. The app accumulates your fully-grown plants and allows you to "grow" more types of plants. Setting the app for longer durations also increases the number of plants that grow simultaneously. The app also has unlockable plants that appear after you reach a target goal. Each plant is also its own plot of land that can be collected into a "farm."
Think Farmville, except it drives you away from doing anything on your phone.
So, all of this seems to be low risk. There doesn't seem to be any retribution when you fail, except a dead digital plant like in Forest. That's where Focus differs. Inside Focus' settings, there's the ability to turn on "Super mode", where if the player fails to meet the set goals, the app hijacks the phone and blasts embarrassing Chinese pop music.
Luckily for me, the music and the app can be turned off right as the music starts.
The app's unique mode of punishment has created a following in China. Netizens have called the app fun and novel with one user interviewed by Sina saying that there's "finally an app that can help me keep away from my phone so I can study for my term exams".
Focus is an interesting way to keep yourself from playing and relying on the smartphone or tablet too much. The app is currently free on Android devices. Sadly, it's China-only, at least for now.
以毒攻毒 国产手游以奇葩方式治你的手机游戏瘾[Sina Games]
【产品评测】专心App-使用评测分享及常见问题解答 [YY.com Forums]


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12 killed, 49 hurt after plane crashes in Kazakhstan
By VLADIMIR TRETYAKOV and DARIA LITVINOVA, 28/12/2019
ALMATY, Kazakhstan (AP) — A Kazakhstan plane with 98 people aboard crashed shortly after takeoff early Friday, killing at least 12 people, while 49 were hospitalized with injuries, Kazakh officials said.
The cause of the crash in the Central Asian nation was unclear, but authorities were looking at two possible scenarios —pilot error and technical failure, Kazakhstan's deputy prime minister Roman Sklyar said.
The Bek Air aircraft hit a concrete fence and a two-story building after takeoff from Almaty, Kazakhstan's largest city and former capital. It lost attitude at 7:22 a.m. (0122 GMT), the Almaty International Airport said.
The plane was flying to Nur-Sultan, the capital formerly known as Astana.
Local authorities had earlier put the death toll at 15, but the Interior Ministry later revised the figure downward, without explaining.
The Ministry did not immediately respond to a request for comment.
In a statement on its Facebook page, the airport said there was no fire and a rescue operation got underway immediately following the crash.
Around 1,000 people were working at the snow-covered site of the crash. The weather in Almaty was clear, with mild below-freezing temperatures common at this time of the year.
Footage showed the front of the broken-up fuselage rammed against a building and the rear of the plane lying in the field next to the airport.
In Almaty, dozens of people lined up in front of a local blood bank to donate blood for the injured.
The aircraft was identified as a Fokker-100, a medium-sized, twin-turbofan jet airliner. It was reported to be 23 years old and was most recently certified to operate in May. The company manufacturing the aircraft went bankrupt in 1996 and the production of the Fokker-100 stopped the following year.
All Bek Air and Fokker-100 flights in Kazakhstan were suspended pending the investigation of the crash, the country's authorities said.
Kazakhstan's air safety record is far from spotless. In 2009, all Kazakh airlines — with the exception of the flagship carrier Air Astana — were banned from operating in the European Union because they didn't meet international safety standards. The ban was lifted only in 2016.
Litvinova reported from Moscow.


University College of Technology Sarawak staff and faculty visited the KORAD head office.
We introduced them to the core technologies we have at KORAD and held a demonstration for our products.
– Learning VR solution technology which uses camera and gesture sensor.
We recieved a great response from the staff and faculty for all of our technologies and products and an intention to cooperate closely in technical cooperation and business alliance.
In addition, the staff and faculty were able to experience the operating environment and actual conditions of VR Open Studio and VR large studio located on the first floor of our office. It was an opportunity for the staff and faculty to compare it with the current broadcasting environment and media production environment in Malaysia. The staff and faculty looked impressed with the state-of-the-art studio environment.
KORAD has established a branch in Vietnam branch with the vision of bringing this state of the art technology to our customers in Asia.


Pole dance today is among the most popular types of fitness. Not only does it look good but it also develops your flexibility, strength, endurance, and coordination. So, if you are into pole dancing, you are certainly on the right way! However, starting to pole dance might be challenging for beginners, especially if a one doesn't have an instructor. Fortunately, there are special apps that help to improve pole dancing skills. Even if you go to a dance studio or to a gym, these apps will be useful to you. They'll keep you on the right track and give you lots of inspiration. Let's begin!
Pole Dance Lessons by Veena is one of the most popular pole dance apps available both on iOS and on Android. The app features lessons created by a famous pole dancer and pole teacher Veena who has been sharing her knowledge with students for a very long time.
All lessons introduced in the app are based on scientific research about our body so that your physiology played into your hands. There is a whole curriculum of pole classes that you may follow as you like. The app also includes instructions on how to buy a good pole. So if you don't have one, this info will be of a great help.
All in all, if you don't have time or money or, maybe, an opportunity to go to a dance studio, this app may serve as an excellent substitute! You just got to remember not to take on too much as you start and go slowly but surely. That said, I wish you to gain progress in pole dancing and, as the app's developers say, start flying!
Pole Dance Syllabus is an app created by PDC (Pole Dancing Community) to guide you through a world of an endless variety of pole moves. It is a well-known fact that pole dance as a sport has been recognized quite recently and still not fully. Before that, it was considered to be just a dance or even a way to earn money in a bar. But we all know that sometimes dancers need to be even more skillful than sportsmen, so the most dedicated pole instructors have decided to gather together to establish an official moves syllabus categorized by levels and a grading system for identifying one's level of skills.
Both of these elements can be found in the app. So, first and foremost, the app contains 336 moves categorized by 6 difficulty levels. All the moves are presented in short clear videos. And, secondly, there is the AAP grading scheme that will help you to rate your progress and celebrate small victories as you progress.
This app is not free, but it is perhaps the most useful app on pole dancing out there. It will give your dancing experience a professional touch and who knows, maybe, you'll become a professional at some point! All the videos are accessible offline, so you can watch the moves and practice the moves any time you want to. Download the app right now and level up every day!
Pole Guide is a free alternative to the app above. This one is so-to-say less serious – it is not made by the professionals. However, the app is great in its own way. It contains over a thousand pole dance moves, and every move is accompanied by pictures. The best part is that it is social, meaning the app's users can upload the photos that show how a certain move is performed by them.
You can share your photos as well! It is always more fun and interesting to learn new skills together. So, if you think you'd rather choose a free pole moves app, let it be this one! Not only will it give you new ideas on what to do next, but it will also give an opportunity to share your progress with other dancers.
Pole Motion is an app that is available only on iOS. The app features lessons performed by Justine McLucas – a professional ballerina and a fitness instructor. All the lessons are voiced, explaining what you have to do in order to reach this or that condition.
There are different kinds of lessons – tutorials, warm-ups, routines, stretches, etc. – suitable both for a beginner and an advanced level dancers. In addition to video-tutorials, there are photos which show how to make a certain move step by step.
This is one of the most convenient apps when it comes to learning pole dancing moves. It is free but once you've downloaded it you'll see that some of the best lessons like on stretching or toning exercises have to be bought. One way or another the app is definitely worth a try! You are lucky if you have an iOS device.
One more pole dancing app for iPhone (and iPad, by the way). This one also contains lessons on how to pole dance. There are 346 video tutorials on how to make different kinds of moves. Basically, you can learn everything by following the instructions in the app. You can start with basic pole exercises and then end up learning how to perform such complicated tricks as pencil spin or boomerang spin-up.
The advantage of this app is that you don't need to sit and search for moves – you just watch something and then try to do it. One by one, you can become a top-notch dancer! The downside is that the app is not free and there's no free trial, so if you don't like the lessons for some reason, you won't be able to get your money back. So if you are risky enough, get the app and start learning!
Pole Power Pole Dance is not an app for learning how to pole dance. This is an app for finding places where you can learn how to pole dance. Wherever you are in the world, you can use this pocket tool in order to find pole venues, stretching venues, etc. Lots of fitness schools are already included in the app and new ones are added all the time!
Besides searching for a place where to train, you can also use the app's video tutorials, instructions, tips and so on. But this part is more of a bonus. One more bonus is a counter that will help you to keep track of repetitions and warm-ups.
All in all, this is a very multifunctional app for pole lovers. If pole dancing is an indispensable part of your life, download the app today and make your life easier!
If you want to be really good at pole dancing, you gotta be really good at stretching! Sworkit app can help you to achieve this goal. Be as stretchy as you like – the main condition is to train, train and train. The app includes over a hundred stretching workouts that are divided into three groups – full body stretch, head to toes stretch, and pilates.
All you need is 5 minutes of your day. You don't have to think what to do. You don't have to be prepared. Just turn on the app, choose a training, and get started!
Stretching will improve your flexibility and make you less vulnerable to injuries. What's not to like? Get the app now and get more stretchy every day! To find out more stretching apps, check out this article: 17 Best stretching apps for runners and dancers (Android & iOS).
So, these were seven useful apps for learning or mastering pole dancing skills. If you know more, please, share your knowledge in the comments below. As for now, we can conclude that there are not so many apps on how to pole dance. Maybe because of the fact that nothing can be compared to a real trainer or maybe because there is a myriad of YouTube videos on this topic which makes such apps almost unnecessary. Nevertheless, there are still good options! Hopefully, you've found the app you were looking for. Stay fit & awesome, be smart in choosing apps!


Before you read on, follow this link, you might find this page with video tutorials helpful as well!
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Connor Jenson
#16 Attackman - St. John's
Hometown: Hutchinson, MN
High School: Hutchinson HS
Eligibility: Senior
2019 St. John's 16 7 4 1 0 0 0 - 0
02/16/2019 Montana W 14-4 1 0 0 0 0
02/23/2019 @ Nebraska W 20-3 2 0 0 0 0
03/21/2019 Montana State W 15-11 0 0 0 0 0
03/29/2019 @ Dayton L 10-21 0 0 0 0 0
03/30/2019 @ Grand Valley State L 3-18 0 0 0 0 0
03/30/2019 @ Illinois W 16-9 3 3 1 0 0
04/04/2019 @ Minn.-Duluth L 8-15 1 0 0 0 0
04/06/2019 North Dakota State W 12-8 0 0 0 0 0
04/13/2019 @ St. Thomas L 9-17 0 1 0 0 0
04/26/2019 @ St. Thomas L 7-8 0 0 0 0 0
05/06/2019 Kennesaw State W 10-9 0 0 0 0 0
03/09/2018 @ Dayton W 13-9 0 0 0 0 0
03/10/2018 @ Columbus State W 15-8 0 1 0 0 0
03/10/2018 Central Conn. State W 16-8 0 0 0 0 0
03/11/2018 @ Bridgewater State W 10-5 0 0 0 0 0
03/17/2018 @ MSU Denver W 11-5 0 0 0 0 0
03/18/2018 Northern Arizona L 7-8 0 0 0 0 0
03/18/2018 Providence W 12-9 0 0 0 0 0
03/24/2018 @ North Dakota State L 6-14 0 0 0 0 0
03/30/2018 @ Minn.-Duluth W 9-8 0 0 0 0 0
04/07/2018 St. Thomas L 10-11 0 0 0 0 0
04/12/2018 Minnesota L 7-15 0 0 0 0 0
04/20/2018 Dayton W 9-8 0 0 0 0 0
04/21/2018 St. Thomas L 6-15 0 0 0 0 0
05/07/2018 @ UC Davis W 18-3 0 0 0 0 0
05/08/2018 Grand Valley State L 9-11 0 0 0 0 0
02/17/2017 Minn.-Duluth W 17-5 0 1 0 0 0
02/19/2017 Missouri State W 18-0 0 2 0 0 0
03/04/2017 Concordia-Irvine L 6-13 0 0 0 0 0
03/15/2017 Montana State L 14-15 0 0 0 0 0
03/31/2017 @ Kennesaw State W 15-4 0 0 0 0 0
04/07/2017 @ St. Thomas L 11-13 0 0 0 0 0
04/13/2017 North Dakota State L 13-14 0 0 0 0 0
05/08/2017 Cal State Fullerton W 10-9 0 0 0 0 0
05/09/2017 @ Concordia-Irvine L 9-10 0 0 0 0 0
02/20/2016 Minn.-Duluth L 7-11 0 0 0 0 0
03/05/2016 @ Grand Valley State L 11-12 0 0 0 0 0
03/06/2016 @ Florida Gulf Coast W 14-2 0 0 0 0 0
04/01/2016 Indiana Tech W 12-9 0 0 0 0 0
04/02/2016 Grove City L 7-10 0 0 0 0 0
04/03/2016 Dayton W 10-7 0 0 0 0 0
04/08/2016 St. Thomas L 8-9 0 0 0 0 0
04/15/2016 @ North Dakota State L 11-13 0 0 0 0 0
04/16/2016 @ North Dakota W 19-5 1 1 0 0 0
04/17/2016 Winona State W 18-6 0 0 0 0 0


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Gay rights a focal point in 2010 race
The DFL candidates for Minnesota governor support gay marriage rights.
The frame around the gay marriage debate in Minnesota has changed. In the middle of Jesse VenturaâÄôs term as governor, âÄúThe BodyâÄù summed up his position on marriage rights in one paragraph of his 2000 book, âÄúDo I Stand Alone?âÄù: âÄúMy dictionary says marriage is a union between a man and a woman. I donâÄôt think we need to be diluting that definition just to make sure gays have the privilege of being in a committed union. I think a term like domestic partnership works fine.âÄù More recently, the ex-governor has changed his tune. While Ventura stops short of granting gay couples the full and equal access to marriage that states like Iowa and Massachusetts have now established, in a 2008 panel discussion on MSNBC he called for full GLBT civil rights based on the principle of separation of church and state. It would appear that Minnesota Democrats sympathize with VenturaâÄôs change of heart, but in the 2010 Minnesota gubernatorial race, their commitment will be put to the test. Not a single declared Republican candidate is in support of same-sex marriage laws, making it a near certainty that this issue will be a focal point for DFL opponents. DFL candidates have already chosen sides in this debate, deciding that gay marriage is a question of civil rights, not of politics. Since they are taking this position now, they cannot and should not back down in the future, regardless of who gets the final endorsement and regardless of how fiercely Republican gubernatorial candidates attack their liberal position. Minnesota voters will reward strong, principled consistency on this often divisive and dicey debate.


A still from the legendary 1962 film "To Kill a Mockingbird," starring Gregory Peck (pictured) as crusading lawyer (and beloved father) Atticus Finch.
Alabama author Harper Lee doesn't speak publicly very often, but she says she's honored President Barack Obama is taping an introduction to a special showing of the movie based on her novel "To Kill a Mockingbird."
USA Network says it will air a fully restored version of the movie Saturday evening. It will include a brief introduction by the president, who recognized Lee at a White House event last year.
Lee lives in the south Alabama town of Monroeville. In a statement released by the network, Lee says she is deeply honored that Obama will introduce the movie to a national audience.
The 50-year-old film features actor Gregory Peck as Alabama attorney Atticus Finch fighting for justice for a black defendant in a small southern town. The character is based on Lee's father.


Hematology: Basics | Try Online Course for Free!
The Hematology Basic Module is targeted at those who have no prior medical knowledge. This course will give you an overview of the basics of Hematology. You will be introduced to blood and its formation as well as the physiology and function of blood cells.
Our expert will also teach you about investigation and diagnosis of blood disorders.
A number of malignant disorders of the blood are characterized by abnormal and uncontrolled growth of certain blood cell types that are associated with prolonged survival even after the establishment of the diagnosis. Myeloproliferative diseases are a collection of disorders of the blood cell lines that are characterized by elevated platelets, white blood cells or red blood cells in the peripheral blood. The myelodysplastic syndromes are quite the opposite as they are characterized by the inability of the bone marrow to produce the normal and different blood cells; hence, can be also defined as bone marrow failure disorders. Myeloma, on the other hand, is a malignant condition of the plasma cells that is characterized by uncontrolled activation, proliferation and the production of abnormal antibodies.
Blood transfusion is a common and safe procedure where blood and/or blood products are transferred from the circulation of one person (known as a donor) to the circulation of another person (known as a recipient) or to the circulation of the patient himself (autologous transfusion) at a different time. It helps to replace blood loss following trauma, surgery, or hematologic illnesses, e.g., leukemia.
EASY TO UNDERSTAND HIS LECTURE.
A fantastic brilliant lecture i thing it is the best of all.


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Posts for tag: orthodontic treatment
Tags: retainers orthodontic treatment
You can't correct a poor bite with braces or clear aligners overnight: Even the most cut-and-dried case can still require a few years to move teeth where they should be. It's a welcome relief, then, when you're finally done with braces or aligner trays.
That doesn't mean, however, that you're finished with orthodontic treatment. You now move into the next phase—protecting your new smile that took so much to gain. At least for a couple of more years you'll need to regularly wear an orthodontic retainer.
The name of this custom-made device explains its purpose: to keep or "retain" your teeth in their new, modified positions. This is necessary because the same mechanism that allows us to move teeth in the first place can work in reverse.
That mechanism centers around a tough but elastic tissue called the periodontal ligament. Although it primarily holds teeth in place, the ligament also allows for tiny, gradual tooth movement in response to mouth changes. Braces or aligner trays take advantage of this ability by exerting pressure on the teeth in the direction of intended movement. The periodontal ligament and nature do the rest.
But once we relieve the pressure when we remove the braces or aligners, a kind of "muscle memory" in the ligament can come into play, causing the teeth to move back to where they originally were. If we don't inhibit this reaction, all the time and effort put into orthodontic treatment can be lost.
Retainers, either the removable type or one fixed in place behind the teeth, gently "push" or "pull" against the teeth (depending on which type) just enough to halt any reversing movement. Initially, a patient will need to wear their retainer around the clock. After a while, wear time can be reduced to just a few hours a day, usually during sleep-time.
Most younger patients will only need to wear a retainer for a few years. Adults who undergo teeth-straightening later in life, however, may need to wear a retainer indefinitely. Even so, a few hours of wear every day is a small price to pay to protect your beautiful straightened smile.
If you would like more information on orthodontic retainers, please contact us or schedule an appointment for a consultation. You can also learn more about this topic by reading the Dear Doctor magazine article "The Importance of Orthodontic Retainers."
While retainers are often viewed as a nuisance, they're crucial to protect the gains made with bite correction. Without them, all of the progress achieved through braces or clear aligners could be lost.
Here's why: The same elastic gum tissue called the periodontal ligament that holds teeth in place also allows them to move incrementally in response to changes in the mouth. That's why we can move teeth with braces or aligners, which put pressure on the teeth toward a desired direction of movement while the periodontal ligament does the rest.
But the mechanics can also work in reverse: With pressure relieved when the braces are removed, the teeth could revert to their original positions through a kind of "muscle memory." The light pressure provided by a retainer is enough to keep or "retain" teeth in their new positions.
The best known retainer is a removable appliance. Initially, a patient wears it continuously and only takes it out during oral hygiene. Wear duration may later be reduced to night time only and eventually not at all, depending on a patient's individual needs.
While effective, removable retainers do have some downsides. Like braces, they're visible to others. And because they're removable, they're frequently misplaced or lost, leading to the added expense of a new one.
An alternative is a bonded retainer, a thin piece of wire attached to the back of the newly moved teeth to keep them in place. Because it's behind the teeth it's not visible—and there's no misplacing it because only a dentist can take it out.
A bonded retainer is a good option, especially if a patient is immature and not as diligent about wearing or keeping up with their appliance. But it can make flossing difficult to perform, and if they're removed or broken prematurely, the teeth could revert to their former positions.
If you decide to go with a bonded retainer, be sure you get some tips from your dental hygienist on how to floss with it. And if you decide later to have it removed early, be sure to replace it with a removable retainer. Either of these two options can help you keep your new and improved smile.
If you would like more information on bonded retainers, please contact us or schedule an appointment for a consultation. You can also learn more about this topic by reading the Dear Doctor magazine article "Bonded Retainers."
Tags: celebrity smiles braces orthodontic treatment
The 2019 Grammy Awards was a star-studded night packed with memorable performances. One standout came from the young Canadian singer Shawn Mendes, who sang a powerful duet of his hit song "In My Blood" with pop diva Miley Cyrus. But that duo's stellar smiles weren't always quite as camera-ready as they looked that night.
"I had braces for four and a half years," Mendes told an interviewer not long ago. "There's lots and lots and lots of photo evidence, I'm sure you can pull up a few." (In fact, finding one is as easy as searching "Sean Mendes braces.")
Wearing braces puts Mendes in good company: It's estimated that over 4 million people in the U.S. alone wear braces in a typical year—and about a quarter of them are adults! (And by the way: When she was a teenager, Miley Cyrus had braces, too!)
Today, there are a number of alternatives to traditional metal braces, such as tooth-colored braces, clear plastic aligners, and invisible lingual braces (the kind Cyrus wore). However, regular metal braces remain the most common choice for orthodontic treatment. They are often the most economical option, and can be used to treat a wide variety of bite problems (which dentists call malocclusions).
Having straighter teeth can boost your self-confidence—along with helping you bite, breathe, chew, and even speak more effectively. Plus, teeth that are in good alignment and have adequate space in between are easier to clean; this can help you keep your mouth free of gum disease and tooth decay for years to come.
Many people think getting braces is something that happens in adolescence—but as long as your mouth is otherwise healthy, there's no upper age limit for orthodontic treatment. In fact, many celebrities—like Lauren Hutton, Tom Cruise and Faith Hill—got braces as adults. But if traditional braces aren't a good fit with your self-image, it's possible that one of the less noticeable options, such as lingual braces or clear aligners, could work for you.
What's the first step to getting straighter teeth? Come in to the office for an evaluation! We will give you a complete oral examination to find out if there are any problems (like gum disease or tooth decay) that could interfere with orthodontic treatment. Then we will determine exactly how your teeth should be re-positioned to achieve a better smile, and recommend one or more options to get you there.
If you have questions about orthodontic treatment, please contact our office or schedule a consultation. You can read more in the Dear Doctor magazine articles "The Magic of Orthodontics" and "Lingual Braces: A Truly Invisible Way to Straighten Teeth."
Tags: orthodontic treatment clear aligners
If your teenager is in need of orthodontic treatment, you might automatically think braces. But while this decades-old appliance is quite effective, it isn't the only "tooth movement" game in town any more. Clear aligners are another choice your teenager might find more appealing.
Clear aligners are a sequential set of computer-generated plastic trays that are worn by a patient one after the other, usually for about two weeks per tray. The trays are fabricated using 3-D computer modeling of the patient's mouth, each one slightly different from the last to gradually move teeth to the desired new positions.
So, why choose clear aligners over braces?
They're nearly invisible. Because they're made of a clear polymer material, they're not nearly as noticeable as metal braces. In fact, they may go completely unnoticed to the casual observer.
They're removable. Unlike metal braces, which are fixed in place by an orthodontist, clear aligners can be removed by the wearer. This makes brushing and flossing much easier, and they can also be removed for eating or special occasions. That said, though, they should be worn at least 20 to 22 hours each day to be effective.
They're becoming more versatile. With some complicated malocclusions (poor bites), braces and other orthodontic appliances may still be necessary. But innovations like added power ridges in clear aligners can more precisely control which teeth move and which don't. This has greatly increased the number of poor bite scenarios where we can appropriately use clear aligners.
If you'd like to consider clear aligners, just remember they require a bit more self-discipline on the part of the wearer than braces. And once the treatment finishes, they'll still need to wear a retainer just as with metal braces to help keep the repositioned teeth from reverting to their old positions.
If you think your teen is up to the challenge and their particular situation can be corrected with this innovative technology, then clear aligners could be a great choice.
If you would like more information on clear aligners orthodontic treatment, please contact us or schedule an appointment for a consultation. You can also learn more about this topic by reading the Dear Doctor magazine article "Clear Aligners for Teens."
Tags: orthodontic treatment lingual braces
Orthodontic braces are a familiar sight, especially among tweens and teens: metal brackets and wires attached to the front of the teeth for all to see. Now imagine the opposite: much the same hardware, but now positioned out of sight on the back of the teeth.
It's not your imagination: It's the latest development in orthodontic technology called lingual braces. Developed simultaneously by two orthodontists in Japan and Beverly Hills, these appliances are placed on the tongue or "lingual" side of the teeth rather than the traditional labial or "lip-side."
Generally, lingual braces can correct any bite problem labial braces can. The difference lies in how each method does its job: Traditional braces exert pressure or "push" against the teeth, while lingual braces "pull" the teeth into better alignment.
So, why choose lingual over labial? For one, they're "invisible" to others: all the hardware is on the backside of the teeth, out of sight. They're also not as readily exposed to blunt force facial trauma, which can damage traditional braces (a driving impetus for the Japanese doctor to develop them for his martial arts patients, and his American counterpart for a law enforcement patient working in a rough area).
Patients may also prefer lingual braces over removable clear aligners, another popular tooth-movement option. Fixed lingual braces achieve the same quality of "invisibility" as removable aligners, but without the inconvenience of removing them as patients must with aligners for eating, snacking or cleaning.
They can, however, be costly, running 15-35% more than labial braces. Patients may also have difficulty adjusting to them because they can affect speech and tongue comfort. However, any discomfort and initial regret with choosing lingual braces tends to fade as most patients grow more accustomed to them after a week or so.
There's one other "perk" to lingual braces—unlike patients with traditional braces who have to wait for their removal to see the finished bite correction, patients with lingual braces get an unobstructed view of their progress all during wear. That can definitely boost morale during the long treatment period!
Lingual braces haven't been around long, so not every orthodontist offers them. But the list is growing, and there soon may be a provider near you for this new teeth-straightening alternative.
If you would like more information on lingual braces, please contact us or schedule an appointment for a consultation. You can also learn more about this topic by reading the Dear Doctor magazine article "Lingual Braces: A Truly Invisible Way to Straighten Teeth."
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Q: Javascript-frames for comment I thinking about using frames (or iframe) for comments, in order to load less data on load.
For example: lets say I have an article with 100 comments. I'll load only the first 10, so when the user click on page 2 i'll:
1) create new frame with 11-20 comments.
2) put the first 10 comments display none.
3) change the onclick on the "2" button to just change the frame's display to block and the others to none.
my questions are:
1) should i use frames or iframes for this?
2) Is this idea is good? or can it make my website too slow?
3) Can google "see" the comments that hide on the frames? (that arent in the page until i click on the right number)

A: Your proposed solution is a really awkward way of doing things.
Allow me to present this idea instead.
First, make your website work without any JavaScript at all.  That way, your pagination buttons will lead to real content and real data.  This will make Google (and other users happy.)
Enclose the comments in a div or possibly a section element.  Choose a ID at random, I'd call it comments.
Then, add some JavaScript to your pagination buttons and use Ajax to go out and just the next set of comments.  Go ahead and replace #comments with the new content.  You can either use a separate API on your server, or you can pass it a parameter which means "just the comments, no body."

redpajama_set_name: RedPajamaStackExchange


In 21st century, PAT has become one of the new trends in the reform of the United States cGMP. In order to learn from foreign pharmaceutical quality control and production management experience, in this paper, the concept of PAT was introduced, the background of drug production PAT and its significance, the development trends of domestic pharmaceutical production PAT were reviewed. Process analytical technology (PAT) has been defined as a mechanism to design, analyze and control pharmaceutical manufacturing processes through measurement of critical process parameters which affect critical quality attributes. PAT checks the quality of raw material attributes both physically and chemically (i.e. at off-line, on-line, in-line). The first steps in an Analytical Quality-by-Design (AQbD) method development include understanding the analysis needs (e.g., purpose, specificity, sensitivity, cycle time, on-line/off-line, qualitative/quantitative, accuracy, precision) and selection of the technique that will meet these criteria. One set of analytical tools applied during the development and scale-up of drug substances and dosage forms include in-situ analytics, chemometrics and modelling i.e., Process Analytical Technology (PAT) tools.
Dipti G. Phadtare, Pawar Amol R, R.B. Saudagar. A Brief Review on Quality by Design and Process Analytical Technology. Asian J. Pharm. Ana. 2016; 6(2): 122-130.


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Q: Geometric Distribution - transformation $Y=x/(x+1)$ I honestly have no idea where to start with this problem:
Suppose $X$ has the geometric distribution with PMF
$$f(x) = \frac 1 3 \left( \frac 2 3 \right)^x, x=1,2,.....$$
Determine the probability distribution of $Y=x/(x+1).$  Note that both $X$ and $Y$ are discrete random variables. To specify the probability distribution of $Y,$ specify its PMF.

A: To specify a variable's PMF, you need two things: (a) a list of what values it can be, and a corresponding list of probabilities of it being those values.
You already have the PMF for $X$, but let's make a table out of it to make it a bit more concrete.
$$\begin{array}{r | l}
  x & p(x) \\ \hline
  0 & 1/3 \\
  1 & \frac 1 3 \cdot \frac 2 3 = \frac 2 9 \\
  2 & \frac 1 3 \cdot (\frac 2 3)^2 = \frac 4 {27} \\
  \vdots & \vdots
\end{array}$$
I obtained the probabilities, denote above as $p(x)$, by plugging each value of $x$ into the given PMF.
Once you have these, you now have a complete listing of what $Y$ can be, along with all its probabilities. For instance, if $X = 0$, then $Y = \frac{X}{X+1} = \frac{0}{1} = 0$ as well; this will occur with probability $1/3$. If $X = 1$, then $Y = \frac{1}{2}$, which will occur with probability $2/9$, and so forth. Using this idea, you could make a table that looks just like the above, to get the the PMF for $Y$.
Of course, it may be more desirable to put this into a formula; you may want something compact like the expression you gave for $f(x)$. I claim that the clearest way to see what such a formula should be is to write out the first 3 or 4 lines of a table like the above, though.


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World Premiere of "Sanctuary": A Film by Lillian Ball | 7-8:30PM
Friday, November 16; 7-8:30PM
There will be Q&A session after the screening with Lillian Ball. John Halpern will moderate the Q&A session.
CLICK HERE TO RSVP
Sanctuary is about a time and place in our contemporary world that harkens back 2600 years.
The Lumbini Crane Sanctuary exists within the 3 square mile Sacred Garden area where Siddhartha Gautama was born. There are plans afoot to replace the 254 acre sanctuary with 5 hotels and a 1000 person meditation center !!
Sarus cranes, the tallest flying birds in the world, have lived in the fields around Lumbini since the time Buddha was young. Though crane numbers are dwindling, they still nest in the area today along with many other wildlife species. Join Venerable Metteyya and others in the conservation of that unique environment, for local people and Buddhist pilgrims alike.
2018 | 29m 35s | Director: Lillian Ball | Post-production: George Chrysiliou
For more information on the film, visit: SanctuaryLumbini.org |
Click here to learn more about the Sanctuary
Lillian Ball is an ecological artist/activist working on wetland issues with a multidisciplinary background in anthropology, ethnographic film, and sculpture. She has exhibited and lectured internationally, including the Taragaon Museum in Kathmandu; the Seville Bienniale; and Reina Sofia Museum in Spain. Numerous awards include: two New York State Foundation for the Arts Fellowships, a John-Simon Guggenheim Foundation Fellowship, and a National Endowment for the Arts Grant. Her ongoing WATERWASH® public art project series combines storm water remediation, wetland habitat restoration, and educational outreach. Completed projects have been accomplished with non/profit community groups along the Bronx River and on Mattituck Inlet, both in New York.
Her recent work in Lumbini, Nepal approaches a crane sanctuary endangered by development at the World Heritage site of Buddha's birthplace with these same locally based concepts. Ball's documentary, "Sanctuary", depicts the effort led by the inspiring Venerable Metteyya to avert the demise of wildlife in Lumbini, especially protecting the Sarus cranes that have been there since Buddha's time. Constructive work Ball is involved with includes: nature/culture exhibitions, signage design, and ecological livelihood enhancement through using invasive plants in basketry. Planning is underway for a public nature walk, conservation educational center and habitat restoration once the Sanctuary has been preserved. These initiatives will reach the millions of pilgrims visiting as well as benefiting the local population. Partners include Lumbini Social Service Foundation, UNESCO, Natural Resources Development Center, International Crane Foundation, Green Lumbini Youth, Animal Nepal, and World Wildlife Fund.
John DiLeva Halpern is an art activist and filmmaker based in New York and working internationally for the past 45 years. His work advocates for culture as a tool for social transformation. He is known for projects related to the preservation of Tibetan culture through such films as Refuge, and Talking With The Dalai Lama. His immersive, interactive cinema event Waking Buddha Live (premiered at Tibet House, 2015) focuses on Western Meditation, while Joseph Beuys/Transformer and his current work-in-progress, Robert Filliou/Touch The Sky, are unique film portraits of renowned, avant-garde artists. He is also an award-winning, international artist, known for his large-scale, interactive, public art such as, New Consume, Bridging, Fresh Air, and Breathsculpture. His 30 YEARS TIBET HOUSE (2018) film can be found on this site. John's articles about Tibet's Self Immolations can be found on the Huffington Post. For more information, visit: http://mdsfilms.com/
Tibet House US Gallery
tibethouse.us