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HomeResourcesBlogCAR T Cells Hurdles to Development and Approval
CAR T Cells Hurdles to Development and Approval
by Scientific Writing Team
In our previous blog post, we discussed the revolutionary immunotherapies known as chimeric antigen receptor T-cells (CAR T). The first CAR T therapies, axicabtagene ciloleucel (Yescarta™) and tisagenlecleucel (Kymriah™), were approved in 2017 by the US Food and Drug Administration (FDA). The significance of these approvals was clear, with FDA Commissioner Scott Gottlieb noting in his October 2017 press release that they represent milestones "in the development of a whole new scientific paradigm."
That CAR T treatments are finally reaching the market after decades of research is exciting, indicating the potential for better, more personalized cancer treatments. However, as often happens with ground-breaking products, the most direct developmental and regulatory path for these therapies has not always been clearly defined. Indeed, regulatory agencies have had to adapt their own thinking along the way and, in the wake of these new approvals and as additional product innovations are made, it is certain that their processes will continue to evolve.
As such, if you are involved in the development of new CAR T therapies (or any novel therapy for that matter), it is critical to understand the current regulatory landscape and its potential limitations, to anticipate regulatory and clinical hurdles that may arise during development, and to adapt proactively and efficiently to new regulatory developments.
In the current post, we present three key hurdles that stand between CAR T as a novel and exciting concept to CAR T as an approvable therapy, along with strategies to help overcome these hurdles.
Three Hurdles to FDA Approval
1) FDA Guidance & Communication
FDA guidance documents represent the FDA's current thinking on a wide array of drug development topics. Unfortunately for those developing novel therapies like CAR T cells, available guidance from the FDA can be relatively sparse, partially because the FDA may still be determining its own best practices. Certainly, guidance documents exist that cover cellular and gene therapies, but most often these documents paint with a broad brush, with no specific recommendations for CAR T products. While the FDA is working to expand their library of guidances, the large number of actively recruiting CAR T-based clinical trials indicates an immediate and unmet need for additional FDA input.
How to Prepare: In the absence of formal guidance documents, leveraging existing information in the public domain can help put you on the right track. While this may not answer all of your questions and there may be nuances in your particular program that present unique challenges, gaining insight into what has worked in the past can still pay great dividends and prepare you for productive interactions with the FDA.
One of the best places to look for this information is on the FDA's website. For cellular and gene therapy products, the FDA's Center for Biologics Evaluation and Research (CBER) maintains a list of approved products that includes links to additional content (for other types of drugs, try searching Drugs@FDA). There you will find a wealth of information about each product, often including the summary basis of approval (SBA), individual subject-level reviews (e.g., clinical pharmacology, toxicology, manufacturing), information requests, risk evaluation and mitigation strategy documents, the approved product label, and so forth.
While these resources can be very helpful for informing your development and regulatory strategy, it is also critical to gauge the FDA's thinking on your particular product and development program. One of the best ways to do this is to engage directly with the FDA in the context of a formal meeting. For CAR T and other cellular and gene therapies, you can reach out to the Office of Cellular and Gene Therapy Products in CBER to request a meeting appropriate for your stage of development (e.g., Pre-IND, Pre-BLA, End-of-Phase, Type C). During these meetings, the FDA can provide critical, on-the-record insights on a wide range of topics including clinical trial design, safety considerations, the sufficiency of your preclinical program to support entry into clinical trials, regulatory strategy, and a host of other topics.
Finally, careful consideration of the nuances of your product that may present unique developmental or regulatory challenges is essential. For example, if your CAR T therapy is to be co-administered with another molecule or using a novel delivery device, additional regulatory requirements may apply (e.g., device and combination product regulations, additional safety assessments). Especially in these and related situations, we advise our clients to begin their interactions with the FDA early and to keep the lines of communication open. Doing so can help prevent costly delays and missteps that could derail your program.
2) Isolation, Manufacturing, and Distribution
Unlike most drugs and biologics, current CAR T therapies (with the exception of certain allogeneic "off-the-shelf" products in development) use a person's own cells to create an individualized treatment. Typically, a patient's cells are harvested at the clinical trial site, transported to a laboratory (i.e., manufacturing site) where they are modified (often using a viral vector to introduce the CAR genetic material) and expanded, shipped back to the clinical site where they may be stored temporarily, and then infused back into the patient usually several weeks after the original isolation. Each step of this process adds additional layers to an already complex system. Potential variability in key product quality parameters (e.g., cell viability, potency) and how these are impacted during storage and shipping are key considerations and may attract additional regulatory scrutiny.
How to Prepare: Beyond gathering information about existing therapies and engaging with the FDA, it is important to generate appropriate plans for each aspect of the clinical and manufacturing process from original isolation through re-infusion and to anticipate potential problems along the way. Clinical site training is a key aspect of this and is often formalized as part of the Risk Evaluation and Mitigation Strategy (REMS) submitted with the marketing application (BLA). Shipping/storage protocols and detailed manufacturing plans are another essential component, as are studies assessing the effectiveness of these plans for maintaining product quality. The testing strategy should include not only "ideal" conditions but also the impact of potential deviations such as unintended shipping delays and suboptimal storage conditions.
3) Product Safety and Long-Term Follow-up
In our previous post, we described the toxic side effects of CAR T therapies, including cytokine response syndrome and on-target/off-tumor toxicity. The substantial risks demonstrated by approved CAR T therapies also include multi-organ failure, late onset leukemia, neurotoxicity, and brain tumors. These toxicities are likely to be associated with any new CAR T therapy, and, as an additional complication, preclinical models are often incapable of identifying the full profile of side effects observed in humans. For these reasons, FDA reviewers will look for a thorough analysis of potential risk and risk mitigation, so that side effects can be rapidly and appropriately addressed.
In addition to acute side effects, it is also necessary to consider long-term safety outcomes. As cellular therapies, CAR T treatments have long-acting biological profiles. It makes them effective cancer treatments, but also indicates a potential for delayed adverse events, immunogenicity concerns, and negative effects on normal cell growth and development. As you prepare to transition to the clinic, consider these risks and the duration of long-term follow-up that will be required. Kite Pharma (now part of Gilead Sciences; YescartaTM) and Novartis (KymriahTM) are both managing long-term follow up studies to fulfill postmarketing requirements and must collect patients' safety information for 15 years. This type of long-term study is costly but making such a commitment to understanding the full safety profile of the therapy is critical for regulatory approval.
How to Prepare: Early-phase clinical trials should be carefully designed to ensure a comprehensive safety assessment, efficient product delivery, and optimal clinical and manufacturing procedures to maintain product quality and safety. Consideration not only of commonalities with existing therapies but also of the unique aspects of your particular product that may necessitate additional safety assessments is an important aspect of this. These considerations, along with experience gained during clinical development of your product, will help inform the eventual REMS that will be submitted with the BLA.
Be prepared for long-term follow-up. Late stage clinical trials will likely need at least 1 year of follow-up data prior to commercial approval, and post-market follow-up periods of up to 15 years should be expected. There is some potential for this period to be shortened based on the mechanism of action and biological profile of the product, including persistence of cells in the patient, duration of expected response, and expected survival rates of the population. Early discussion with the FDA and careful design of early stage clinical trials may allow you to reduce costly long-term follow-up.
CAR T therapies represent an exciting era of personalized medicine, and we will undoubtedly see new CAR T drugs continue to reach the market. Understanding the hurdles to developing these therapies, such as a lack of CAR T-specific FDA guidances, the complexities of manufacturing and distribution, and potential safety concerns coupled with the need for long-term follow-up, will increase your chances of success and help get your product well on its way to commercialization.
Featured Consultant
Devin Welty, Ph.D.
Senior Consultant, Nonclinical & Clinical Pharmacology
Dr. Welty has over 25 years of experience in preclinical and clinical pharmacology leading organizations and projects teams from early discovery to approval. He has extensive experience in pharmacokinetics, pharmacodynamics and systems pharmacology. Dr. Welty also has experience using PK/PD as a tool to help determine dosing strategies for CAR-T and other programs.
What Are CAR T Cell Therapies?
Key Hurdles in Immuno-Oncology
Monoclonal Antibodies: Past, Present and Future


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Home » Cricket Home » News » Heavy Rain Abandons Ireland-Bangladesh ODI in Dublin
Heavy Rain Abandons Ireland-Bangladesh ODI in Dublin
By: Cricketnext Staff
Edited By: Suyash Upadhyaya
Last Updated: May 10, 2019, 01:13 IST
Image: Twitter
Persistent rain at the Village Ground in Dublin forced the abandonment of the One-Day International - third of the tri-nation series - between Ireland and Bangladesh on Thursday (May 9) without a ball being bowled.
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Even the toss could not take place with a light drizzle meeting the two teams when they arrived. As forecast, the drizzle soon converted into heavy rain and at 2:15 pm local time, the umpires decided to call the game off.
The teams shared two points each which took Bangladesh to the top of the points table. Following their crushing victory over West Indies in an earlier game, they now have six points after two games. West Indies who are five points are second on the table while Ireland having lost their opening encounter are on two points.
However, the points system left Bangladesh head coach, Steve Rhodes unimpressed. Though Bangladesh are leading the table, receiving just two points from this game against the competition's weakest team has left a bitter taste in Rhodes' mouth.
"The system is best for some hot countries in international cricket. In Scotland, Ireland and England in May you get a lot of rained-off games and sides maybe lose out a little bit in rained-off games," Rhodes said. "Maybe that needs looking at. If we had won this game it would have been easier to play some of these guys but we got only two points for the no result and it may affect in the opportunities for the guys and that's a shame.
"Little bit disappointed (because) we did feel this was the game that we really wanted to win as it would put us in a very strong position. But we can do nothing about and so mixed feelings because I really wanted more points than two."
This is the third game abandoned in the last two days in the United Kingdom. The Scotland-Afghanistan game at Edinburgh was abandoned without a ball being bowled while the first ODI between England and Pakistan in London was called off after just 19 overs.
Ireland will take on the West Indies in the fourth game of the tri-series, in Malahide, on Saturday.
Cricketnext Staff
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first published:May 10, 2019, 00:59 IST
last updated:May 10, 2019, 01:13 IST

redpajama_set_name: RedPajamaCommonCrawl


Grass cutting is being maintained by Armagh City, Banbridge and Craigavon Borough Council despite funding cuts by Transport NI, said a council official.
The council said it is maintaining both its own land as well as non-council land across the borough, despite a moratorium on services by the Department of Regional Development.
The public have been angry that the borough has become a jungle in some parts due to the lack of grass cutting.
However, in a statement, the council said it is continuing to maintain the service.
A council spokesperson said: "Because of the high profile media campaign on grass cutting people will know of the pressures the system is facing, but members wanted people to know that locally they are providing a service in the interim.
Lord Mayor of Armagh, Banbridge and Craigavon, Councillor Darryn Causby said: "We didn't want our ratepayers to suffer because of Departmental budget cuts.
"We know people across the borough have great civic pride, so we wanted to maintain a standard our ratepayers expect.
"Of course this comes at a cost, with 14-16 cuts per year between February and November.
TransportNI normally pays councils a fee for cutting grass along roadside verges.
Despite this funding currently being being withdrawn, the council has maintained its usual level of service on land it owns and on TransportNI lands council had a previous agreement to cut.


communicable disease such as malaria, TB, HIV, and outbreaks.
Most recently the West Africa Ebola outbreak.
There are hot topics in global agenda with good reason.
cause enormous suffering in some of the poorest areas of the world.
until more recently, have been hanging under the world's radar.
So we're trying to define or capture what we mean by global health.
are currently one of the greatest burdens on health worldwide.
population, their impact on the young cannot be underestimated.
the individuals, the families, and actually the country's economy.
NCDs must be considered a huge part of global health.
And targeting NCDs is really a vital part of the approach to healthcare globally.
diabetes, and respiratory diseases, and many are preventable.
lifestyle factors, and economical factors, as well as treatment.
A year end, high level meeting took place on NCDs in New York in September, 2011.
Many issues are raised and some of the key points I'm going to list.
to address prevention and control of non-communicable diseases.
as well as coordination to address NCDs.
that NCDs lead to unprecedented healthcare needs in low and middle income countries.
And NCDs impact the international efforts of development.
Other key messages included the investment in NCDs must be integral to development.
The health system strengthening is essential and paramount.
The house subs access for all needs to be provided.
cycle of NCDs and poverty needs to influence development programs.
similar framework that yet to be developed are also critical in addressing NCDs.
of management and the burden of NCDs.
Read them and put on notes on the discussion board about your thoughts.
There is no one single comprehensive definition of global health.
and examined global health from a variety of different perspectives.
But this provides belly introduction.
to visit regarding global health.
And as we identified, no one comprehensive definition.
So just as you finish your second week, how do you define global health?


Big crossover vehicles confuse me a little. I don't understand why I love the 2017 Audi Q7 so much, but I do.
Audi lavished some much-need attention to Q7 for 2017, taking a chisel to an exterior that hadn't changed in almost a decade. The sharper, more angular body looks a little less locomotive than before, with a front end that's lower and sides that feel tucked in rather than bulging. It's a good look and further differentiates it from corporate cousins Porsche Cayenne and Volkswagen Touareg.
Audi does interiors really well, and Q7 benefits from the latest styling and technology the company has to offer. And that's to say – really classy, sleek and attractive.
Q7 used to be offered with a choice of diesel or gasoline powerplant, but thanks to the VW diesel scandal, it's strictly gasoline for the Q7 in the US for now. The 3.0-liter turbo V6 is no slouch, but doesn't get the same reported fuel efficiency ratings that the diesel was famous for – dishonestly, as it turns out. Shame.
Even with all this goodness on offer, I'm still confused. The big crossover is obviously an on-road vehicle, without a hint of ruggedness anywhere. Who is it for? In my hometown of Los Angeles, I see plenty of Q7 crossovers in traffic carrying a lone driver, not the big family I'd expect. Audi's got two smaller SUVs, the Q5 and Q3, that would seem to be better choices for commuting.
But the Q7 makes a statement – a big statement. And maybe that's what it's all about.
Read my 2017 Audi Q7 Test Drive And Review on Forbes.com.


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+420 608 810 032 info@comaccal.com
Comac Cal s.r.o.
We produce induction flowmeters, flow watches, dispensers, heat meters. We provide assembly and service, training and, of course, technical support.
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COMAC CAL s.r.o. has been engaged in development and production of measuring and sensor technology since its establishment
Thanks to our own development centre, we have been able to offer the customer solutions made to order so that they can fully suit to their requirements and in all sorts of industries.
The roots of our company date back to 1987 when a special group under a housing cooperative came into existence to deal with the development of heat meters for residential buildings. Since then, a wide range of measuring systems and sensors have been developed and manufactured to offer solutions based on measured quantities or measuring principles.
The in-house development centre solves the most varied specific problems and helps find out the best starting point for client's tasks. Thanks to establishment of the authorized Metrological and Calibration Centre, we are capable of testing meters and sensors and overall solution designed by our team of workers.
Our customers come from all sorts of industries, including petrochemical, food processing, water management, power engineering or mining with the appropriate ATEX.
The development department affiliated to SBD Havířov was established.
The Havířov Cooperative was established to develop and produce heat consumption meters with an induction flowmeter. The first KMH 10 heat meter was produced, which was launched on the market as an approved operating gauge since June 30, 1992 and a year later it was followed by a microprocessor version of CALOR 20 for heat measurement and FLOW 20.
Company renamed to COMAC CAL s.r.o.
The approval of a new type of heat meter and flowmeter CALOR 30 and FLOW 30 complemented by the possibility of data transmission via radio signal was approved. COMAC CAL s.r.o. successfully sells its products to the Slovak Republic and Poland. The company moved to new premises at Horní Těrlicko 737.
A separate metrology center, authorized by the Czech Metrology Institute, was established to verify the water meters and the calorimetric counters of the heat meters.
The company comes with new types of certified CALOR 40 heat meters and FLOW 40 flow meters for business. It is supplemented by the first flow meter FLOW 35 introduced in the previous year, which is exclusively dedicated to industry. For data transmission, the product line was supplemented by GSM data transmissions via GPRS.
All products of COMAC CAL s.r.o. passes into a full-rolled version and doubles the O-ring safety seal.
The battery version of FLOW 45 induction flowmeter and a new FLOW 33 industrial flowmeter including the FLOW 37 dosing version were introduced.
The compact flow meter FLOW 38 with IP 67 was put into production.Enclosure and industrial design case to fully meet the requirements for the most demanding industrial applications including the dosing version
Approved FLOW 33 Ex Series for use in explosion-proof areas specifically designed for mines. The OEM flow sensor FLOW 32 was included in the production with an evaluation electronics inside the flowmeter body. During the year, MACNAUGHT was established for oval wheel flow meters and STS SENSORS for pressure gauges, level gauges, temperature sensors and conductivity sensors including data transfer modules.
Into the products we included a calorimetric fluid flow monitor completed in the following year with additional outputs including current 4 ÷ 20mA
Paddle wheel flowmeter (FPW) has been included into the production process. FPW is
designed for unpretentious applications. The advantages of this meter include low acquisition
costs and there is a possibility to order a local display.
We are extending our production premises to facilitate increasing customers demands.
According to EU requirements we have also obtained MID certificate for billing purposes.
We are a purely Czech company that has been operating on the Czech and foreign markets since 1990. We are engaged in the development and production of induction heat meters and flowmeters. Thanks to many years of experience, we are able to offer individual solutions for our customers.
Těšínská 737/30, Těrlicko
735 42 Czech Republic
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It was a great plan. And, as with so many great plans, things didn't go exactly as expected.
This all started a year ago, when DH and I decided to explore spending an extended vacation in the UK, Brexit notwithstanding. We'd rent a place with a kitchen so we wouldn't be dependent on restaurant meals; we'd see friends in London; we'd have a home base from which to explore; and best of all, we'd have direct flights between Austin and London.
We choose Devon, as it's one part of England neither of us has fully explored, and make our bookings.
Not having a crystal ball, we don't know that we'll actually be in Oregon come October since the new house we're building in Austin won't be ready until January. This means we now have to fly to Austin in order to catch our "direct" flight, and of course do the same upon returning. Not to mention the additional cost of hotels, etc.
No matter. We've rented a cute little National Trust cottage in Devon (Coastal Cottage #3, which sounds picturesque), described as "cozy" (which turns out to be code for "minuscule"); we have a car with GPS; what can go wrong?
First clue: the three cottages are at the end of a literal long and winding road: rutted, unpaved, narrow, rocky, passable by only one vehicle at a time and our rental car pretty much takes up the entire width of it. If someone is coming in when you're going out, one of you has to back up a quarter mile. This will get old pretty damn quickly. As will unlocking the entry gate's padlock in pouring rain.
Pros: The cottage is nicely equipped with pots and pans, washer-dryer, and a reasonably comfy bed.
Cons: The TV doesn't work. There is no Internet. There is no mobile connection so cell phones don't work either. There is, however, a phone box outside that you can unlock with a key. But let's say you break your leg falling down the treacherous winding stairs connecting the bedroom and sitting room, and you cannot crawl outside to get to the phone?!? This place is really remote. It is also cold and clammy and there is a fireplace, but we'll soon discover that when it is warm enough downstairs, it is boiling hot in the bedroom — and not in a good way.
The sun is shining so we head off to explore Peppercombe Beach, which is a short hike.
Beautiful, but the beach is all rocks.
Pro: We can get Internet service at the closest pub. A pint was never so tempting!
PORT ISAAC (The"Port Wenn" of Doc Martin) is very pretty, despite heavy rain and wind that's blowing my umbrella inside out. That's why there are so few photos. Watch the show to see it at its best!
On the way home, we discover Camel Valley vineyard (Cornwall's largest vineyard), where the tasting room manager is very hospitable and gives us generous pours since we're the only people to stop by on this rather dreary day.
The Eden Project, an educational charity, is designed to raise awareness of changes in our environment.
The visitor site in Cornwall, nestled in a huge crater, features a group of massive Biomes, stunningly planted to replicate select environments along with natural inhabitants such as native birds. It houses the largest rainforest in "captivity" and serves as a backdrop to striking contemporary gardens, concerts and year-round events.
Worth a visit if you're in the area, the village is privately owned and no cars are allowed, owing to its extremely steep cliffside location. Supplies are delivered on pallets dragged up and down the hill — or on donkeys!
A beautiful stately home built in the 1820s, Arlington Court features carriages, extensive grounds to explore, fancy furniture, and typical crap that rich Victorians used to collect, such as vast quantities of ordinary-looking shells, all lovingly displayed on velvet trays.
OUR LOCAL. It's not the closest pub, but it's very welcoming, has good food, and we can sit for an hour checking e-mail with free WiFi and nobody giving us the stinkeye.
First week of October, 2018.
This entry was posted in Travel, Uncategorized and tagged bloggers 50+, Cornwall, Devon, long holidays, National Trust, touring UK, vacation, Victorian, wordpress on December 2, 2018 by adguru101.


The Supreme Court has ruled that Employment Tribunal and Employment Appeal Tribunal fees are unlawful as they prevent access to justice and are indirectly discriminatory.
The Supreme Court has ruled that Employment Tribunal and Employment Appeal Tribunal fees are unlawful as they prevent access to justice. The fee regime also indirectly discriminates against women who are disproportionately affected by the higher fees charged for "Type B" claims, which include discrimination claims. The Supreme Court has ruled that the legislation which introduced fees was unlawful from the start and the legislation has therefore been quashed. The Government will now have to refund all of the fees it has received and will no longer be able to charge fees, at least until it introduces a new, fairer regime.
In R (Unison) v Lord Chancellor and another, Unison challenged the legality of employment tribunal fees, arguing that the fees were set at such a level and remission criteria so restricted that many claimants would be unable to afford to bring claims. The fees therefore unjustifiably interfered with the right to access to justice. Unison also argued that the fees regime indirectly discriminates against women as they bring more discrimination claims and are therefore disproportionately affected by the higher fees charged for discrimination claims.
The High Court and Court of Appeal rejected Unison's arguments. However, the Supreme Court has upheld Unison's appeal, ruling that fees are unlawful on both grounds.
Fees must be affordable not in a theoretical sense, but in the sense that they can reasonably be afforded. Worked examples indicated that hypothetical claimants would need to restrict expenditure that was ordinary and reasonable for maintaining living standards in order to be able to afford fees.
The Supreme Court also considered that fees could not be justified as a necessary intrusion on the right to access to justice. Although the aim of transferring some of the cost burden from taxpayers to users of the system was legitimate, the Government had not shown that the fee regime it introduced was the least intrusive means of achieving that aim.
The parties accepted that charging higher fees for Type B claims, which include discrimination claims, disproportionately affects women and so the only issue which the Supreme Court had to consider was whether the fee regime could be justified. The Supreme Court considered it could not. The Government had not shown that the higher fee charged for Type B claims was more effective in transferring the cost of the service from taxpayers to users. In addition, in some Type B claims, such as pregnancy dismissal, the higher fee did not correspond to a greater workload placed on the tribunal.
The judgment applies to fees in both the Employment Tribunal and the Employment Appeal Tribunal. The Supreme Court has ruled that the legislation introducing the fees was unlawful from the start and the legislation has therefore been quashed. The Government will now have to repay all Employment Tribunal and Employment Appeal Tribunal Fees received since fees were introduced in July 2013 (reported to be around £32m) and will no longer be able to charge fees, at least until it comes up with a different, fairer regime. A regime modelled on the one used in the County Court, where the level of fees is linked to the amount claimed, seems the most likely way forward.
The judgment also throws up other questions, including whether claimants who did not bring claims and who are now out of time for doing so will be able to bring claims out of time on the basis that it is just and equitable to allow them to do so (the test in discrimination cases) or that it was not reasonably practicable for them to bring the claim in time (the test in unfair dismissal and unlawful deductions claims). Also if a claim was struck out for non-payment of a fee, will it now be possible to appeal that decision out of time?
One thing is certain. Employers can expect the number of employment tribunal claims to increase again.


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New Perspective: From Pandemic to Performance
The Changing Role of Coworking in the Workplace Ec...
The Changing Role of Coworking in the Workplace Ecosystem
David Smith • 8/3/2020
Although coworking has been dramatically impacted by COVID-19 and the economic downturn, it's likely to remain a viable and important workplace environment for a variety of user types and reasons. In this report, we explore some of the trends and factors that are likely to shape the future of coworking. We also take a look at coworking in nearly 30 metro areas throughout the Americas.
Download the report to learn more.
Subscribe to get Cushman & Wakefield's latest Recovery Readiness updates and insights. We also look forward to hearing from you to see how we can help.
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Research • Workplace
Recovery Readiness: A How-to Guide for Reopening your Workplace
The "Recovery Readiness: A How-to Guide for Reopening your Workplace," outlines some of the best thinking and practices that our more than 53,000 professionals have compiled across the globe and also includes insights from key partners.
Video • Workplace
Webinar: Recovery Readiness Replay
On this webinar, the RRTF announced the release of "Recovery Readiness: A How-to Guide for Reopening your Workplace," a comprehensive guide for real estate tenants and landlords on reopening workplaces as stay-at-home restrictions are lifted.
Article • Policy
Global Policy Report
It is clear now that what was originally a supply-side shock—and to a lesser extent an export demand shock for the global economy—has morphed into something far more pernicious.
Kevin Thorpe • 4/2/2020
We look forward to connecting with you.


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{
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        {
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        public static string AddProcess(int process)
        {
            ActiveProcesses.Add(process);
            return string.Join(",", ActiveProcesses.OrderBy(x => x));
        }

        public static string DeletePRocess(int process)
        {
            ActiveProcesses.RemoveAll(x => x == process);
            return string.Join(",", ActiveProcesses.OrderBy(x => x));
        }
    }
}

redpajama_set_name: RedPajamaGithub


Georges Seurat's fascinating work The Gleaner is an ambiguous abstraction of an important figure in nineteenth-century French culture, which pushes the motif of the bending subject in Seurat's work to a dramatically curved extreme. Yet in spite of being included in several major exhibitions and available in the British Museum's public collection, the drawing, also known as A Man Gleaning , remains barely documented and demands further research. To dwell in detail upon the specificities of a single drawing throughout the form of an extended essay is an uncommon approach in the Anglophone literature on Seurat's work on paper. This study will address the imbalance in the field by offering a sustained critical account of this one early-1880s drawing by the Neo-Impressionist artist. With reference to contemporary optical theory and comparative approaches, this piece argues that Seurat's plant-like gleaner fathoms the surface of visual anatomy; intervenes as an entoptical phenomenon; blurs the bounds of legality; enacts a metaphor for information and evokes vitality. The drawing is a troubling, multivalent assessment of what it might mean to glean: to gather what reapers have left behind.


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You are in: Home » The Polar Museum » SPRI Museum news
Centenary « The Polar Museum: news blog
A Brief History of the Polar Library
Frances Marsh, Senior Library Assistant writes about the history and future of the Library at the Scott Polar Research Institute.
I recently watched this 1961 clip of Anglia Television reporting on the Scott Polar Research Institute. There is a section in in the middle, where the reporter speaks to Harry King, Librarian of SPRI between 1955 and 1983. King's legacy has left its traces in the library today and it has been fascinating to reflect on some of the similarities of the library in 2020, some of the big changes since the 1960s and also some of the things which could develop in the future!
Anglia Television interview Librarian Harry King in 1961
Library users
In the video, King explains that the library's purpose is to gather together all polar literature for people to consult rapidly. The Institute was always envisaged as a centre of information for polar researchers, explorers and scientists yet to come and the library, naturally, was a vital part of that. The library today serves a whole range of people, from the cohorts of MPhil and final year Geography students working on polar and glaciological topics, doctoral students and academic researchers based at the Institute, to visiting scholars from all corners of the globe, researchers working for government and industry, and any member of the public interested in the polar regions, whether that be for personal family history reasons, a penchant for polar fiction or research interests in glaciology. I wouldn't be so rude as to say, like King did, that we regularly get 'odd enquiries' but I am always amazed at the variety of research, interests and passions that the Polar Library supports!
Polar Library Collections
Our collection's development since the early 1920s means that the cutting-edge polar research publications of their time now form an important part of the historical record of polar scholarship. In keeping with the history and original intentions of a polar research institute, the 'nucleus' of the library collection came from the published results of Scott's Terra Nova expedition. Bequests of private libraries have helped build the collection from then on and it is for this reason that the Institute has a strong special collection, especially on the history of British polar exploration, with titles dating from the 16th century. Hugh Robert Mill, for instance, donated 500 books which now form the base of the Antarctic special collections. In 1951, the Library purchased the collection of Arctic literature belonging to the German researcher Leonid Breitfuss.
Nowadays, many information needs can be fulfilled by online information, whether open access or thanks to a University subscription, but it's also clear that our physical collections are very significant, with people seeking out SPRI as the only library in Cambridge, the UK or even further afield to hold both historic and more recently published literature. The library selectively purchases new publications based on the current research interests across the Institute and to maintain a comprehensive collection for polar research of the future.
International cooperation for collection development
Something else that Harry King mentions in the clip is the absolutely crucial role of international cooperation for building a collection that is not limited to English-language material. The Polar Library holds scholarship in over 90 different languages and we have built up a comprehensive collection over the years thanks to partnerships with libraries internationally. We still run a journal exchange, sending the online publication Polar Record and receiving copies of many titles such as Études Inuit Studies, Advances in Polar Science, Led i Sneg and the Falkland Islands Gazette. The library has actively collected material on and from the Russian Far North since the 1930s, though it accelerated in the 1950s and 60s when Terence Armstrong set up many exchange partnerships with Soviet institutes and libraries. This makes our Russian collections particularly strong and the tradition continues today with my colleague Eleanor's work to build and promote the Russian-language collections.
The library space
A 1934 article in Nature recounts the opening of the current SPRI building, highlighting the beautiful parquet floor and oak furniture, and proclaiming "these two rooms will be spacious enough for their purpose for a very long time to come". The empty shelves that you see in early photographs of the library are now packed full and indeed even 30 years later as the Anglia Television clip explains, "Information has accumulated to such an extent that the library is already hard-pressed to accommodate it". An extension to the whole building, including a huge expansion to the library space, was financed by the Ford Foundation in the 1960s and 30 years on, in 1998, the Rotunda extension was completed, adding yet more space for books to be shelved floor-to-ceiling on the curved walls. Space is still an issue for us today, and though we do not routinely deaccession items, we are thinking about how our collection works with and relies on other libraries across Cambridge, and how we might utilise the space in the Library Storage Facility in Ely to hold some of the physical copies of periodical titles that are available to consult elsewhere online.
Harry King was Librarian at SPRI in a pre-computerised era, when the library collection was listed on catalogue cards. In 1987, most of that catalogue moved from the physical index cards into a computerised system; state of the art for its time! More recently, it has migrated from that clunky, unsupported system into the University of Cambridge's library catalogue, iDiscover, which has opened up our collections to all those searching the University's print and electronic holdings, and indeed library users across the globe.
In the postwar era, the Polar Library developed its own system for organising knowledge of the polar worlds; an adapted version of the Universal Decimal Classification (UDC) scheme. Brian Roberts is credited as its 'principal champion' whose 'intellectual capital' built Polar UDC into a detailed classification system suited to the collection at SPRI. Looking to the future, the Polar UDC classification scheme is something that we hope to update and develop so that it continues to function as an organisational system for 21st century polar knowledge. Working on the classification scheme is part of a wider strategic priority to decolonise the library, ensuring that the principles of our knowledge organisation system do not perpetuate harmful and problematic western understandings of the polar regions and Indigenous peoples. Alongside this, we are thinking about how we teach about the information in the library collection and how we can continue to proactively collect diverse, multilingual and multiepistemic material.
Library futures
Looking to the future, I think there is a role for the library to play in supporting excellent new initiatives such as Polar Impact and Pride in Polar. The library has occupied a central role in the polar research community at SPRI and across the world for the past century and I am certain it will continue to do so for many years to come. We should reflect on the inclusivity our spaces, collections and practices and think intersectionally about some of the barriers that the library presents. I think some of those barriers come down to the institutional narrative and history the library paints of itself. Looking at the account I've just written, I can't help but notice how the narrative centres around a selection of white men. In reality, the library has also relied on the unacknowledged labour, expertise, knowledge and generosity of many women in its 100 year history, and I would love to learn more about the diverse people, institutions, relationships and knowledges that have influenced the development of the library collections, space and organising principles; perhaps less prominent but no less significant in the development of a truly multi-faceted polar library.
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The Women who made SPRI
During lockdown, I have been working on a new temporary exhibition which will celebrate SPRI's centenary year. Though it has been strange to think about a new exhibition, not knowing exactly when it will open or when you will be able to see it, it has been lovely to learn more about SPRI's history. In particular, it's been fascinating to uncover the stories of the women whose lives have been linked to SPRI since its inception and beyond. I'd like to introduce you to some of my favourites in the exhibition, and if you'd like to see them again, or learn more about any other women of SPRI (or men, for that matter!) then do come along to our centenary exhibition once the museum reopens.
The Founding Mothers
Founded in 1920, SPRI was the brain-child of Terra Nova geologist Frank Debenham, but it took more than one woman to bring his ideas to fruition. Perhaps the most well-known of these early female pioneers was Kathleen Scott, the indomitable widow of Captain Robert Falcon Scott. Kathleen was a well-renowned sculptor in her own right who had studied under Auguste Rodin in Paris long before meeting her future husband. As well as donating several statues to the museum, Kathleen was instrumental in introducing Debenham to the right people to help get SPRI off the ground, and in securing funding for the Institute. Once SPRI had become a reality, British naturalist Oriana Wilson helped to furnish it with some of the most famous polar objects it holds today – her husband Edward Wilson's Antarctic watercolours. Oriana persuaded Debenham to include a purpose built gallery in the 1934 building, so that the paintings could be put on display and admired.
Kathleen Scott, Captain Robert Falcon Scott and George Frederick Wyatt on the bridge of the 'Terra Nova'
Oriana Wilson
The Shapers
In the late 1920s the British anthropologist Dr Ethel John Lindgren began a career studying different cultural groups across Inner Mongolia and Siberia. Lindgren gathered knowledge and collected cultural objects from the people she studied, later donating many of these objects to SPRI's museum collection. Her collection was used to teach aspiring western polar explorers the best ways to deal with the harsh environments they would be facing. Lindgren also lectured the MPhil students at SPRI about the people she had met and their ways of life. Lindgren's collections, and the many other objects donated to the Institute, had to be accurately recorded and catalogued so that they could be put to good use. In the early days of SPRI, this work fell to women who volunteered their time. Miss W M Drake, arranged and catalogued a good proportion of the collection, including equipment, maps and books. Her meticulous record keeping in all areas ensured the smooth operating of the Institute and its collections and she later went on to paid employment as the official Assistant to the Director. Her work forms the foundations of our records today.
'Overnight camp on the banks of the Oura' by Ivan Dmitriyevich Bulychov. Presented to SPRI by Dr E Lindgren.
Miss W M Drake
The Knowledge Holders
Women connected to SPRI were instrumental in the formation of our knowledge about the polar regions. Hilda Richardson was a glaciologist and the only employee of the International Glaciological Society following its creation in 1936. The society, which had its headquarters at SPRI for almost 70 years, became a well-renowned international organisation under her leadership, publishing prestigious academic journals and organising international symposia.
In our understanding of the polar regions, it can be all too easy to only consider western perspectives, but indigenous knowledge is invaluable to understanding and surviving in the Arctic environment. As Dr Lindgren showed SPRI's early MPhil students, the foremost knowledge holders in the Arctic are the people who live and work there, their ancestors having inhabited the far north for thousands of years. Gusdiana was a Tunumiit from North Eastern Greenland who was instrumental in the expeditions of British explorer Gino Watkins' in the 1930s. Photographs in SPRI's archives show Gusdiana sewing kayaks for the western explorers, who would use these traditional boats to hunt seal. Kayaks are made by stretching animal skins over a frame and sewing them together to make a watertight vessel, and this process of stretching and sewing is traditionally done by Inuit women. Without Gusdiana, Watkins and the men of his expedition would not have been able to hunt using these specially designed craft.
Portrait of Gusdiana
Gusdiana sewing skin on to a kayak as Gino Watkins watches her work.
Women have been instrumental to SPRI over its 100 year history. Whether by supporting its early years, to ensuring the standard and care of its collections, to making the discoveries and teaching the knowledge which informs its work. SPRI is now home to many female scientists, social scientists, museum, library and archive professionals, financial and administrative staff, and without them, and the women who came before them, the very character of the Institute would not be what it is today.
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A Brief History of SPRI
A lot has changed in the hundred years since the Scott Polar Research Institute (SPRI) was officially founded. In the 1920s, western explorers were still visiting the polar regions in wooden boats, but not fifty years later technology had advanced so much that man had landed on the moon. Another fifty years went by and now scientists and researchers can overwinter at the South Pole – once so inaccessible as to be deadly – in a station fully fitted with comfortable beds, hot meals and internet connection. So, with all the change and upheaval of the last century, what has happened to SPRI?
1920 – The Scott Polar Research Institute started life in the attic of the Sedgwick Museum – crammed full of polar artifacts, equipment and scientific data. In spite of these modest beginnings, the camaraderie and friendly atmosphere which are still characteristic of SPRI today were created by the men and women who visited the attic, united by their interest in the polar regions.
1934 – A group of famous designers collaborated on a purpose-built home for SPRI on Lensfield Road. The renowned architect Sir Herbert Baker designed the building, while MacDonald Gill painted the spectacular domed maps which can still be seen in the Memorial Hall. Captain Scott's widow, Kathleen – a distinguished sculptor – donated her own works which still keep watch over the Institute above the door and in the garden on Lensfield Road.
Opening day at the new home of SPRI, 1934.
MacDonald Gill and Priscilla Johnston paint the Memorial Hall domes
Bust of Captain Scott by Lady Kathleen Scott
1940s – During World War II SPRI helped the British government research clothing and equipment for Arctic missions. The museum collection at SPRI was initially a teaching collection, designed to equip polar explorers with the hard-won knowledge of their predecessors. During WWII, this specialist knowledge of equipment and polar clothing was especially useful when the War Office was considering a possible northern invasion route into Europe.
1959 – SPRI was heavily involved in setting up the Antarctic Treaty which protects the Antarctic as a continent for scientific research. An incredibly important agreement for the governance of the Antarctic even today, the Antarctic Treaty ensures that nobody owns the Antarctic. It also dedicates the continent as a place for peace and science. SPRI scientists helped to produce this remarkable treaty.
1968 – A lecture theatre, laboratories and 'cold rooms' for research were added to the building, more than doubling its size. SPRI is a specialist institute with specialist facilities – as scientific research within the university became ever more advanced, so more unusual features were added to SPRI. Today a large freezer in the basement is used for everything from testing kit to freezing our historic museum collections to protect them from insects and other pests!
The SPRI Lecture Theatre
1970s – SPRI scientists perfected the invention of radio echo sounding. This revolutionary new glaciological technique meant that scientists could fly over the ice sheets and measure how thick they were by emitting radio waves and measuring how long it took them to bounce back to the plane. This technique led to the discovery of a hidden world of lakes and volcanoes beneath the surface of the Antarctic ice sheet.
Radio Echo Sounding
1980 – SPRI welcomed the first students to its brand new Polar Studies program which still runs to this day. SPRI has always been a place of learning – first, it was for collaboration and the analysis of data by early explorers, then it became somewhere for budding polar scientists to benefit from the experience of the past. Today, students at the Institute study everything from the social sciences to climate change.
1998 – The Shackleton Memorial Library opened, securing SPRI's position as the largest polar library in the world. The library at SPRI is home to an enormous collection of over 54,000 monographs, DVDs, Masters and Doctoral theses, as well as pamphlets, press-cuttings, periodicals and around 18,000 maps. As a resource on the polar regions it is of international importance.
The Shackleton Memorial Library
2000s – SPRI was a well established hub of polar research and information as public interest in the polar regions continued to rise. As the general public became increasingly aware of the effects of climate change on the polar regions, SPRI's role as a resource and centre for research on these fragile ecosystems became even more important.
2010 – The Polar Museum underwent a total refurbishment, in time for the centenary of the death of Captain Scott and his companions on their return from the South Pole in 1912. The museum now has permanent displays on the indigenous communities of the Arctic, the western explorers of the Arctic and Antarctic and contemporary scientific research in the polar regions. There is also a dedicated temporary exhibition space.
2020 – The Scott Polar Research Institute celebrates 100 years of polar research. So much has changed since the attic days of the early 1920s, and who knows what the next 100 years have in store for SPRI, but if the last century is anything to go by then it's sure to be busy!
SPRI today
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A Century of Polar Research
The year 2020 marks 100 years since the establishment of the Scott Polar Research Institute (SPRI). While our founders could never have imagined what this year would be like, we are grateful to the foresight which lead them to create an Institute, a building and most importantly, a community, which has dedicated itself to researching and understanding the polar regions ever since.
The Scott Polar Research Institute today.
Let's wind the clock right back to the very beginning – Scott's British Antarctic Expedition 1910-13 (Terra Nova). Frank Debenham and Raymond Priestley, geologists on the expedition, realised they needed a place to share their data, and the lessons they had learned on expeditions, with other polar explorers and researchers. The Terra Nova expedition ultimately ended in the tragic death of Captain Scott and the other four members of his polar party on their return from the South Pole. But Debenham and Priestley remembered their idea for a 'polar headquarters' and in 1920 it was made a reality thanks to funds donated after Scott's death.
The Southern Party upon reaching the South Pole. British Antarctic Expedition 1910-13
Frank Debenham examines geological samples. British Antarctic Expedition 1910-13.
In 1920 the Scott Polar Research Institute was officially opened as part of the University of Cambridge and it flourished. Polar explorers and researchers shared their knowledge and experience with the next generation of scientists. Documents and objects formed comprehensive archival and varied museum collections. People wrote from far and wide to ask questions of the experts who worked there, and the veranda of the old building was found to be just the right size for oiling sealskin kayaks. In 1934, the Institute moved into its current home on Lensfield Road – adorned with Kathleen Scott's sculpture of her late husband above the front door.
Bust of Captain Scott by Kathleen Scott above the entrance to the Polar Museum.
In spite of its Antarctic beginnings, SPRI was always also interested in the people and environment of the Arctic. Terence Armstrong and John Elbo were employed to work in the Russian and north American Arctic in the 1940s and researchers from the Institute continue to work with Arctic communities to this day. Increasingly in recent years, SPRI has been privileged to learn from the knowledge and advice of visiting indigenous scholars, artists and community representatives.
Visiting artist Willy Topkok viewing our Alaskan collection
In the Antarctic, SPRI scientists pioneered a technique known as radio-echo sounding in the 60s and 70s, which allowed glaciologists to measure the depth of ice in the Antarctic ice-sheet. This was made possible by instruments designed and developed at the Institute in a project led by Stan Evans and Gordon Robin. For the first time, we were beginning to understand how much ice was actually in Antarctica!
Today, SPRI contributes significantly to our global understanding of climate change and its impact on the polar regions. Building on the work of previous expeditions and scientists, as well as spearheading new research in glaciology, glacimarine environments and remote sensing.
Researchers from the RESPONDER project team launch a drone
SPRI continues to fulfil its promise to educate the next generation of polar researchers. An MPhil degree in polar studies was introduced in the 1970s, its present-day form taking shape in 1980. PhD students from across the world also undertake vital research across a wide range of academic areas. Their work is enriched by SPRI's unparalleled archives, picture library and museum collections which educate and inspire researchers and public alike. What's more, the SPRI library is the largest library of the polar regions in the world.
The Polar Library
In its hundred year history, SPRI has continually adapted to new challenges and questions in polar research. It remains as relevant today as a site for learning as it was at its conception. This year, we will be sharing our history in more detail in a series of blog and social media posts, and we can't wait to have you along for the ride.
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16th September 2020 by Webmaster


There are some recipes I cook, nail, and share with you as soon as I can. Other times I work at a recipe week after week until I get it just right. This is one of those recipes. It's been awesome since the very first time I made it, but I've been working to create a healthier version while still keeping it absolutely delicious.
And you know what? This final recipe, which uses plain yogurt and very little oil happened to be better than all of the others. The flavors of the whole ingredients (especially the apples and bananas) are more apparent and it's the moistest (ewwwwwww hate.that.word) banana bread I've ever sunk my teeth into.
Naming this light, yet hearty breakfasty bread was no easy task. It's made with whole wheat flour, apples, bananas, carrots – hence Whole Wheat ABC Bread. Another contender: 1-2-3 bread since it contains 1 apple, 2 carrots, and 3 mashed bananas.
Whatever you like to call it, it's quickly becoming this year's version of my apple cake since I've been making it nearly every week. Now that I've nailed down a recipe that delivers the healthiest and the yummiest results there's no signs of stopping now!
In the bowl of an electric mixer fitted with the paddle attachment or using a hand-held mixer, mash the bananas. Add the sugar, canola oil, yogurt, eggs, and grated carrots. Mix to combine. Remove bowl from electric mixer.
In a separate bowl, combine the all-purpose flour, whole-wheat flour, baking soda, salt, cinnamon, and nutmeg. Whisk to combine.
Add dry ingredients to wet ingredients and mix with a spoon or spatula until combined. Add chopped apple and chopped walnuts. Mix until distributed evenly throughout.
Spray a loaf pan with cooking spray. Add batter. Bake 65-75 minutes until a tester comes out clean. Let cool in pan for about 10 minutes before turning out onto a cooling rack.
This entry was posted in Baked goods, Breakfast on October 31, 2013 by Paige Greenfield.
Happy Friday friends. We made it! Robert and I are flying to Kansas City tomorrow morning to celebrate our final wedding of 2013. But first, I wanted to leave you with this recipe in case you plan to spend some time in your kitchen this weekend: Maple walnut granola. It's my absolute favorite this time of year. I make one to two batches each week and eat it every single morning for breakfast. I add it on top of plain Greek yogurt with some sliced strawberries. I've also been known to pour some in a little bowl and snack on it for dessert.
Sure, you could easily buy granola in the store, but this is so simple to make and so worth it. All of the sweetness comes from the natural sugars in maple syrup (just 1/2 cup for the whole thing) and you get healthy, filling fats from olive oil and lots of chopped walnuts. There's also a generous sprinkling of cinnamon and a hit of nutmeg that makes it totally season-appropriate. A generous bowl of this stuff can keep me full from about 8am to 1pm.
After some trail and error, I finally discovered the secret to getting those big clumps of granola. When you pull the granola out of the oven, let it sit on the baking sheet without touching it until it's cooled — about 20 to 30 minutes. You'll get those giant mounds that make it difficult to put away before you've munched on half the batch.
In a big bowl, combine oats, coconut flakes, and walnuts. In a separate, smaller bowl add the olive oil and maple syrup (note: if you give the 1/2 cup measuring cup a quick spritz with cooking spray before adding the maple syrup it pours out much easier). Stir together the oil and maple syrup and pour on the oat mixture. Using a spatula, mix until oat mixture is totally coated. Add the cinnamon, nutmeg, and salt, and mix again until everything is coated.
Spread it onto a parchment-lined baking sheet. Bake (no need to stir) for 50-60 minutes until evenly browned. Remove from oven and let cool completely, about 20-30 minutes, until cool and dry to the touch before breaking up with your hands or a spatula. Store in an airtight container.
This entry was posted in Baked goods, Breakfast on October 25, 2013 by Paige Greenfield.
First things first….a new blog design! It's still super basic and will likely undergo several more changes, but the old one was so dark I really needed a change ASAP. As I mentioned earlier this year, I have some big plans in store for this little blog. More to come in the future, but for now it's a little upgrade to make things lighter and brighter around here. There's also an updated "About" section and an Instagram feed to the right. I feel better already!
Now on to the really important stuff: I'm finally back with a recipe! Ohhhh and it's a really good one, too. Sweet potato, arugula, bacon and caramelized onion quiche. All in a flaky (albeit store bought) crust. One day, I'll venture into the world of homemade pie crust, but for now I was perfectly happy to reach into the fridge and unroll the prepared piece of dough.
I combined two awesome recipes from two of my favorite blogs–this frittata from Big Girls Small Kitchen and this quiche from Gimme Some Oven. What I loved, too, were the instructions for cooking the sweet potato and caramelized onion the night before from the BGSK recipe–it's not necessary, but I had the time Friday evening and it made a big difference Saturday morning. By the way, if you're not feeling like spending an hour caramelizing onions it's totally cool. In the instructions below I offer a delicious time-saving alternative.
It was a perfect weekend breakfast that totally captured the flavors of fall. I served it with a frothy homemade latte (thanks to my new Nespresso machine that I'm totally in love with) and a sliced Michigan green apple. It was exactly the boost I needed to dive into a lengthy weekend To-Do list. What's not to love?
For the onions, coat the bottom of a big pan with olive oil and heat over medium heat. Add the onions and cook until they start to soften. Give them a stir so they're evenly spread across the pan. Turn the heat to low and allow the onions to cook, untouched, for 10 minutes. Stir and allow them to cook again, untouched, for 10 minutes more. Continue with these 10 minute increments until they've cooked about 40-50 minutes and are browned. Sprinkle with salt. Either set aside or, if making ahead, allow onions to cool to room temperature and store in an airtight container in the fridge. Note: If you don't have time to caramelize the onion, see note below.
While the onions cook, roast the sweet potato. Preheat oven to 400. Peel potato and cut in half. Then cut into 1/2-inch thick pieces. Toss in a bowl with some olive oil, salt, and pepper. Arrange in a single layer on a baking sheet and roast 25-30 minutes until they just start to brown. Either set aside or, if making ahead, allow potato to cool to room temperature and store in an airtight container in the fridge.
When ready to make the quiche, preheat oven to 350.
Place pie crust in an ungreased pie plate. Bake for 8 minutes. Set aside.
Cook bacon in a pan until crispy. Remove to a paper towel-lined plate. Note: if not caramelizing the onion, saute chopped onion in some of the bacon drippings until softened, about 10 minutes.
In a bowl, whisk together the eggs. Add the milk, flour, baking powder, and some salt and pepper and whisk to combine. Stir in onions, sweet potato, and arugula. Crumble bacon into pieces and add to bowl. Stir until combined.
Pour quiche filling into crust. Bake 45-55 minutes until a tester comes out clean. Allow quiche to rest for 5-10 minutes before slicing and serving.
This entry was posted in Breakfast on October 15, 2013 by Paige Greenfield.
I have always loved granola (sweet clusters of goodness, what's not to love?), but this recipe has taken things to a whole new level. Obsessed may be more like it.
Last week Robert and I flew to the east coat to celebrate my PopPop's 85th birthday in Ocean City, Maryland where Robert met a few dozen family members for the first time. It was so fun and so special. (I think I owe him a diagram so he can see how everyone's related!) We then spent a few days in New York City with my family and I even had a chance to show him around my hometown on Long Island. While staying with my parents, I finally got to try the homemade granola my mom's been raving about for a while now. And she was right – it was insane! The best way I can describe it is light, crunchy, with just the right amount of sweetness. I didn't realize it until I tried her's, but so many times granola can feel heavy. Not this stuff! The batch my mom made had dried blueberries as well as chopped almonds and walnuts.
When I got back to Chicago I knew I had to make a batch of my own ASAP. When I looked at the recipe I realized I could use coconut oil instead of olive oil. I hadn't used coconut oil since I made this recipe so I figured it was a great opportunity to see what else it could do. I also found these roasted coconut chips at Trader Joe's, which provided the perfect crunchy addition.
You could easily add some dried fruit, too, but my favorite way to eat granola is over plain non-fat greek yogurt with fresh sliced strawberries. Yum!
Preheat oven to 300 degrees. Combine all ingredients in a bowl and toss to combine. Pour onto a parchment-lined baking sheet. Bake about 50 minutes, stirring once or twice while baking. Let cook on baking sheet.
This entry was posted in Breakfast on May 13, 2013 by Paige Greenfield.


text:
Game Of Thrones Watch: Season 3, Episode 4 - And Now His Watch Is Ended
Published: Apr. 22. 2013 1:05 AM
"...a taste of the real world where people have important things taken from them."
Now that was the first great episode of this season of Game of Thrones. Not that the previous three weren't well executed in their own right but "And Now His Watch Is Ended" was more engaging because it was way less concerned with (re)introducing the several story lines or characters and instead had the action escalate significantly. And that's without Jon or Robb. It also shouldn't come as much surprise that the fourth installment of the season contained several large developments, or 'oh shit moments' as one of my professors used to say, since last year's "Garden of Bones" is one of the very best episodes of HBO's fantasy to date. "And Now His Watch Is Ended" will probably end up being regarded in the same light. Of course, you can't have all the excellent payoffs without the setups and last week's "A Walk of Punishment" (another series high in ratings), and the two before that, should get some of the credit for doing a lot of the heavy lifting.
"My sword-hand. I was that hand."
Insert 'it's hard to lift with one hand joke' here. "And Now His Watch Is Ended" starts right where last week cut off (sorry, that was my hand joke) and I loved the use of a close-up of Jaime's hand dangling around his neck as a way to open the episode. In fact, this week was also a step up from the already high cinematographic standards with fantastic, even breathtaking, shot after shot. This season will also mark when everyone realizes that Nikolaj Coster-Waldau is the real deal and not just a pretty face. And hair. Jaime is one of the most interesting characters in the books, and now the series, because George R.R. Martin, D.B. Weiss and David Benioff go to great lengths to show his privilege before adding him to the list of characters having to deal with losing what is most precious to them. Well, he's no longer got the sword-hand or, you know, his identity but at least he's got Brienne. Was stealing the sword a suicide attempt? Hoping to go out by the blade instead of being a 'broken thing' like Bran? A powerful scene followed by another with the large Lady convincing him to stop wallowing in self-pity and get some revenge. And food.
"Look little loves, a spider in the garden. Run along now, grow strong."
While Jaime is stuck in the literal muck, the other Lannisters are all sitting pretty in King's Landing. Not that being there is any safer with all the scheming going on and this was an especially whisper-filled week with extra attention paid to Varys and his various visitors and visits. Yes, I did write the speech from V For Vendetta. First up was Tyrion who went to see the spider in order to gain some more information about Cersei's assassination attempt on him during the Battle of the Blackwater. Of course, the eunuch doesn't deal in proof but he does assure the youngest lion that all good things, like revenge, come to those who wait. He's got the story and dude in a box to prove it. Soon after, Ros sits down with her new boss to talk about Littlefinger, her 'old' boss, and his plans to take Sansa with him when he leaves for Eyrie. She's a smart one and I like what they're doing with her character this season instead of simply having her in sex scenes that spout exposition. His final encounter in "A Walk of Punishment" was probably my favorite because, well, Diana Rigg is just incredible as the Queen of Thorns. But before getting to the end result of their banter, there are a few non-Varys sequences in the capitol that need mention.
"The revenge you seek will be yours in time."
As the spider is busy crawling around King's Landing and spinning his webs, the Lannister and Tyrell relationship seems to be growing more tenuous. Well, according to Cersei anyway. Joffrey seems more than happy with the current state of affairs, giggling like a little boy as he tours his pretty bride to be around the extravagant sets (seriously, great production design) and Tywin doesn't seem all that concerned with the fact that Margaery has successfully sunk her claws into his grandson. Besides, he plans to set the boy straight and must continue writing those secretive letters. It's not a particular good week for the 'Queen Regent' as she continues to watch her power slip through her fingers not to mention have the pleasure of Dad telling her she's essentially worthless. We know, however, that the Tyrells are indeed full of schemes and the latest has to do with the aforementioned Varys and Olenna conversation concerning the fate of Sansa. Such a pretty girl with a famous name, she might just make the perfect bride for a young Lord in the closet who somewhat recently lost his real lover. I must admit, after all the shit the eldest Stark daughter has been through, I was pretty happy to see her have a nice moment with Margaery that seems to offer her everything she's ever wanted.
"You're fighting for ghosts."
As for the other Stark children, as I said there's no Robb or Jon this week (and Rickon, well, who really cares about him) but we do catch up briefly with Bran before having an awesome scene with Arya and the Brotherhood Without Banners. Bran continues to have his green dreams where he's chasing the three-eyed crow as well as encouraged by Jojen and this time it pits him in a rathe emotional scenario. Not only does the young Stark have to face his fears and climb but he's then met halfway up the tree by Cat who, only doing what any caring mother would do, reinforces his fear and sends him back to reality where Jojen is also waiting. Arya's storyline in "And Now His Watch Is Ended" takes us to the BWB's secret lair and we're introduced to a kind of familiar face in Beric Dondarrion. I say kind of because we have technically seen this character before when he was dispatched by Eddard in the first season but Game of Thrones has since recast the part with Richard Dormer. I'd say it was one of the more memorable character introductions in the series so far, with the man rocking the eye-patch almost immediately praising Arya's courage (a good way to win the fans' favor) and challenging the Hound to trial by combat. Awesome. I like this pair, Beric and Arya. Who am I kidding, I like Clegane too.
"Put him back where he belongs."
Theon was having a tough go of it to start the third season, stuck in a prison and being tortured for his crimes in Winterfell, however, soon a mysterious young hero came to his aid and not only set him free but also saved his ass (literally) while on the loose. This week the two continue their quest to meet up with Theon's older sister Yara at Deepwood Motte, with the young man leading Lord Greyjoy into the bowels of some concrete structure. There, Theon shares his story with his savior, baring his soul about his relationship with the Starks and how he truly feels about the betrayal. Alfie Allen has been a real pleasant surprise since the middle of the second season, providing a consistently engaging performance with a role that is really emotionally demanding and could easy go off the rails. I've also been purposefully using words like hero and savior to describe the 'boy' because as we all know by know, he was having a little bit of sadistic fun with the captive, letting him loose only to bring him right back to his torture chamber. That is not a nice thing to do and the amount of joy Iwan Rheon's character was taking in Theon's pain was a little unsettling. Can you say crazy? And yes, I know who he is but since the show hasn't said his name, nor will I!
"Whose throat are you going to cut, old man?"
Things were equally crazy even farther north, with some of the remaining men of the Night's Watch starving to death while they are holed up in Craster's Keep. The dissent that started to show amongst the men in black during "A Walk of Punishment" quickly returned with Rask once again one of the primary figures stirring the pot. Sam's also got his hands full trying to help Gilly's baby escape the fate of the other daughter-wife sons. Not long after Lord Commander Mormont leads a funeral for a recent fallen member of the brotherhood (hm, a ragtag group of soldiers and civilians out to do good, sounds like another recently formed Brotherhood in Westeros) things get heated in the Keep with another Night's Watchman taking exception with Craster's rationing of the supplies. Right when Mormont seems to have regained control, the starving soldiers spring to action and take care of the 'Godly man' once and for all.The Commander's too honorable to let that stand and draws on the traitors only to receive a knife in the back courtesy of Rask. That craven! Even with the injury, Mormont almost chokes the scum to death and the good guys (like Grenn and Edd) also enter the melee on his behalf. Sam splits but not in his usually cowardly way, this time he's worried for Gilly and her baby's safety and they all run away together.
"It is done."
It must have been a really sensational episode because I've wanted to start every thread so far by saying that it might be my favorite of the night. That being said, Daenerys' storyline this week, even though it only consisted of one extended sequence, was probably my favorite segment of "A Walk of Punishment." I don't think I've enjoyed the time spent in the Free Cities this much since the first season finale that saw the introduction of the now famous dragons. And they continue to look rad. Dany is all business as she comes back to deal with the slaver and complete the transaction that will see her gain 8000 Unsullied (eunuch slave warriors who are completely obedient) for one dragon. Of course, Jorah and Barristan (and we) should have known that a mother would never trade her children for anything and the Khalessi makes short work of that rude pig as well as all his slavers and soldiers only seconds after the deal is done. Extra-crispy. This section also contained many of those aforementioned stunning shots, with Jorah walking through the smoke towards a sun soaked and almost defiant Dany coming to mind. Khalessi also doesn't do slaves so the next thing she does after murdering her opposition is offer them all their freedom before asking them to stay and fight at her command. If only the bickering and scheming foes in Westeros could also see the final shot...
Game of Thrones Season 3 returns next Sunday with Episode 5, "Kissed By Fire," at 9 p.m. ET on HBO. The series stars Peter Dinklage, Kit Harrington, Emilia Clarke, Lena Headey and Nikolaj Coster-Waldau.
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Youtube used to show the list of all keywords used to tag a particular video in the description section but a few years back they stopped displaying this information. But you can still find these tags by viewing the HTML source of the video page and then checking out the Open Graph or OG tags. OG Tags are standardized markups that Youtube uses on all its videos. So let's see how this can be done.
Step 1: The first step is to open the video in your browser and then view the source of the video page. You can view the HTML source of a page by right clicking on a blank area and then left clicking on the 'view source' option (as shown in the image below) or by clicking CTRL + U on your keyboard. .
The following image shows you how to view the source in the Chrome browser but it is the same in all browsers. Some browsers use the term 'View Page Source' and some others use the term 'View Source'.
And there you have it, if the video author has used tags for his video, you will be able to see all the tags.
Note that these tags are not auto-generated by Youtube but are custom tags inputted by the author of the video. So if the author does not use tags, then your search will not return any value.


Welcome back to my inbox!!! Very nice to see you!! Can't wait to find out what is on page 11!!
Glad to be back (after total silence in 2015)! As for page 11, it was quite a graphic description of a dog's death 😱 – I sensed it was coming and I was STILL shocked.


Sheffield United manager Chris Wilder insists the signing of Gary Madine will "not wreck my football club".
The Blades this week signed the 28-year-old on loan from Premier League side Cardiff City.
Wilder had been desperate to bring in a striker in January to bolster his forward line as third-placed United chase promotion from the Championship.
But the signing of Madine – a controversial figure in his time at neighbours Sheffield Wednesday – has divided opinion among Blades' supporters.
Madine, then playing for the Owls, was sent to prison for 18 months in 2013 for assaulting two fans in separate attacks in Sheffield nightclubs.
On his release he joined Bolton Wanderers before Cardiff paid £6m for the striker 12 months ago.
Gary Madine is Sheffield United's second loan signing of January.
Now Wilder hopes Madine can replicate the impact he had on Neil Warnock's team and help the Blades follow the Bluebirds into the Premier League.
And the Blades boss has called for supporters to trust his judgment in bringing Madine back to Sheffield.
"I am not daft, I am not going to bring someone in who is going to wreck my football club," said Wilder. "An unbelievable amount of hard work has gone into getting us into this position, possibly more than any other club in this division.
"I have not had £50m to spend, an open chequebook. We have had to work extremely hard on the training ground, recruitment, game to game, to get into this position.
I've made the decision, and it's my decision. I understand it might not be backed fully but people must look at the bigger picture with what we're trying to achieve, and Gary helps that.
"It might split and divide opinion because of what's happened in the past. I understand that it's a game based on opinions.
"I'd like to think I've gained the support and trust of the supporters with my background, and my knowledge of the club and the supporters and the league, what's available and what we need to go forward.
"I've made the decision, and it's my decision. I understand it might not be backed fully, but people must look at the bigger picture with what we're trying to achieve, and Gary helps that.
Gateshead-born Madine signed for the Owls in 2011, netting 26 goals in 67 league starts.
He was booed and jeered playing for Bolton at Bramall Lane last season, but he grabbed the winner.
Wilder has never been afraid to sign former Wednesday strikers, Madine following the same path as Caolan Lavery and Leon Clarke in arriving at Bramall Lane.
The striker's decision to reject several other Championship offers, preferring a return to the Steel City, also impressed Wilder.
"Gary wanted to come," he said. "He had the b**** to do it, he could have taken the easy way out and joined another club.
"That's got to be admired and supported. I think the majority of our punters are really fair and understand that what's gone off in the past, he's played at the other side of the city, he's done some daft things in the past.
"But to want to come to the football club and play, he gets my support, and I'd like to think the majority of our support.
"We have to trust that Gary is going to be good for the football club.
Wilder has brought in Madine and Everton's Kieran Dowell on loan this month to strengthen his side's promotion credentials.
The Blades are just two points off the automatic promotion places, and second-placed Norwich City, with 20 games remaining.
Both loan players are set to be included for tomorrow's visit of Queens Park Rangers to Bramall Lane.
The Blades picked up maximum points from their three games over Christmas, winning at home against Derby County and Blackburn Rovers before victory at Wigan.
Wilder revealed Madine has not been immune to some dressing room banter as he quickly integrated himself with his new team-mates.
"When he walked into the changing room he knew half of the lads and has played against the other half," said Wilder.
"There's been a lot of mickey taking going on, 100 per cent. The changing room runs itself. We all know what makes players tick and the wind-ups.
"Bringing good players in, that shakes the rest of the group up too. We've done that with Gary and Kieran.
"He's bullied people before, that's part of the game, but he can play as well. His technical ability is good. It's a positive signing in an extremely difficult market.
"I genuinely hope supporters put their personal things aside because if any group deserves full backing it's this group. The players have been full tilt.
"If you look at the effect the support has had over the last two home league games, if there was ever a snapshot of what support can do, it was then.
"If we can replicate that then we'll be in with a shout of winning a lot of those games.


#RailroadFire 6:02pm PT: Fire knocked down, contained.
#RailroadFire Details/Update 5:34pm PT: 10 acres, forward progress slowing. 3 structures impacted. 0% containment. Red Cross is setting up a shelter at Golden Valley HS.
#RailroadFire Update 5:13pm PT: Requesting Quint 126 to respond for structure fire operations on Alder Drive. Heavy fire in the attic of 1 unit.
Update 7:58pm PT: Structure Protection Groups have been set up on Ivy Lane, Alder Dr, and Trumpet Dr. A Type I Engine Strike Team from @VCFD and @LAFD en route. 10 Engines total.
Update 4:40pm PT: BC22 is now Incident Commander. Fire is 5+ acres with structures threatened in multiple directions. Req Sheriff for Evacuations and traffic control.
Update 4:37pm PT: 3rd-alarm ordered, 3-4 acres burning currently, running uphill, structures threatened.
BREAKING NEWS: Santa Clarita, California - Firefighters are battling new 2-alarm wildfire with structures threatened and/or involved on Monday, July 30th, 2018 off of 20959 Vía Estrella in Santa Clarita, California.


text:
Youngsville Man Goes Viral, Gets Celebrity Shoutouts For Living His Best Life at Lafayette Mardi Gras
DJ Digital Published: March 4, 2022
Facebook, John Weatherall III
While Mardi Gras 2022 is officially over, carnival season continues for one Youngsville man.
On Fat Tuesday, Steven Barbosa just wanted to hit the Lafayette parades and enjoy the Mardi Gras festivities that we've all been deprived of for the last two years. What he didn't know was that a 10-second clip of him having fun at the Lafayette Mardi Gras parades would go worldwide within days.
The clip, posted by popular Lafayette videographer John Weatherall III, shows Barbosa in sunglasses gripping his American flag tumbler while bopping and singing along to Kevin Gates' 2013 club banger "Thinkin' With My ****."
Whether it was the juxtaposition of a clean-cut fellow turning up to the NSFW lyrics from Gates (shout out to the DJ playing explicit music for tens of thousands of people in a public family setting) or just the pure joy that many described as a "whole mood," the video clip took off in a big way.
To date, the clip has over 400,000 views and nearly 20,000 shares on Facebook alone. This doesn't count the views on Weatherall's TikTok, Instagram, or the numerous reshares and reposts.
For instance, the video was reposted by superstar DJ and producer, Diplo on his social media.
There have also been reposts from artists like Mystikal and Kevin Gates' own Bread Winner's Association, but when it comes to why this particular video has had such big reach Weatherall tells me that he thinks that it simply comes down to Barbosa putting smiles on faces.
When I saw him on the Parade Route, I noticed him feeling the song so I started recording on my iPhone and I guess just him feeling the lyrics to Kevin Gates in that moment and Gates being a popular artist from Louisiana on top of that made people love it! He definitely put a smile on a lot of people faces, just from the comments I've seen on the videos 😂🙌🏾
Weatherall's parade recap videos have become one of the most anticipated parts of Mardi Gras season and his videos capture a version of Mardi Gras that falls somewhere between the big city pageantry of New Orleans and the raw and "real" traditions that are still carried out by krewes in Church Point, Mamou, and Eunice.
In addition to the Lafayette parades, Carencro, Youngsville, and Scott have only grown in size and popularity through the years and Weatherall manages to capture the melting pot of fun and unique culture that everyone from our area is familiar with, no matter their age, race, or walk of life.
Maybe that's why Barbosa's clip has been so popular.
With over a million views on TikTok within 48 hours, and thousands of comments across all social platforms—Barbosa's vibes are transcending, and the comments have definitely reflected that.
Speaking of Barbosa's inbox, it definitely has been "lit" as friends and strangers have been hitting him up nonstop since his video hit social media. His reply? Very simple.
Barbosa's wall has been lighting up with love from people ranging from locals to strangers from afar.
attachment-Screen Shot 2022-03-04 at 7.42.30 AM
I reached out to Barbosa who said he's been nicknamed "spicy white" and is definitely "feeling the love."
I absolutely love it. It shows how great our southern culture is and how music connects us. I love when people come together to have fun and put all the craziness in the world out of their minds. I just love people lol
Speaking of love, I reached out to the promoters of the upcoming Kevin Gates concert at the Lafayette CAJUNDOME and we're hooking Steven up with a pair of tickets to see his favorite artist live in concert on April 30th.
Who knows, he may get on stage to show off those Mardi Gras moves again.
You can check out Steven's video along with all the other Mardi Gras recaps from John Weatherall's socials by tapping through below.
Now that we've located Steven, can we do this woman next? She is also a mood.
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Filed Under: diplo, john weatherall, kevin gates, Mardi Gras, mystikal, parade, viral
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Another relatively quiet day, somewhat dull. So look back to yesterday's good things—today's are the same.
1. Time to myself for writing.
It was a good day. But also kind of a boring one. So it's sometimes hard to find/think of positive things . . . Sometimes I have to get very basic. 1. I'm healthy. 2. My needs are met. 3. I have a loving family.
I really want amazing, wonderful things to happen. But it's all relative, isn't it? The things I take for granted (above) are things some people pray for every day. So maybe it wasn't an exciting day. And maybe nothing amazing happened. But it was a good day. Because of those three things and so many more.
Scott home from his trip.
My son found his glasses.
Dance party with the kids = cardio + fun.
Bangers, beans & mash (one of the only things I can actually cook).
Reading Good Omens with my 10-year-old and remembering how much I enjoy that book.
Two review requests for Peter.
Fun dinner out with my two little ones.
Finally getting to watch X-Files premiere.
I'm halfway to getting 10 reviews for Peter on Amazon. That's sort of the magic number as many outlets require the book have at least 10 reviews before they'll feature it.
Friends who support me and help me when I have to make hard decisions.
Salon night! And I made up a new nail color that is awesome (and they named it after me)!
More nice reviews for Peter.
Fun stuff in the mail.
A bit more progress on rewrites.
Not having to do the evening routine with the kids.
Two nice reviews for Peter.
I know I'm supposed to find three good things no matter how small, but there just wasn't a whole lot going on. It was a pretty boring day. It's actually been a pretty boring week, my book release notwithstanding. Hmm.
Do I really need two other good things?
Okay, well, I got in an extra long walk because it was the nicest weather we'd had in a while, and also we had Chinese food for dinner.
But did I mention MY BOOK WAS RELEASED? Go get it here.
McDonald's. Not a healthy choice, but I need a treat now and then.
Being featured on The Story Reading Ape.
House to myself for the morning!
Halfway to my weight goal (trying to lose the 5 lbs I gained over the holidays).
Cheese. Like, really good cheese.
Ricky Gervais. I think he's brilliant.
Plans cancelled unexpectedly means not having to put gas in the car.
Starting to lose the holiday weight.
Short and painless orthodontist appointment.
Finally getting back to writing!
Getting back to my morning walks.
A productive trip to the mall.
Discovering Making a Murderer on Netflix.
My 10-year-old son came in third in his age bracket in a 5k.


The winter months & shorter days can sure drop the bodies vitamin D level! Lower vitamin D levels mean higher risk for cardiovascular disease. We have so many studies that all point to vitamin D deficiency as a risk factor for heart disease, congestive heart failure, peripheral arterial disease, strokes, high blood pressure and diabetes.
The fact that Vitamin D acts as a hormone has been essentially not taught to patients in the conventional medical model. A quick scan of the science will tell you vitamin D is involved in regulating more than 200 genes throughout the body. It keeps abnormal cells from multiplying in breast tissue and colon tissues. As you get older you you absorb less vitamin D from diet and produce less vitamin D in the skin and if you are not going outside in the early mornings you are at risk for many diseases from low levels of vitamin D. If you are over weight or obese you are at risk for low vitamin D levels because fat cells absorb vitamin D and keep it from circulating throughout the bloodstream.
REMEMBER: Sunscreen will block the vitamin D so get out early in the morning for a long walk while the sun rays are not so intense. You could also try liquid sunscreen that is a favorite for our family. However, at the beach and swimming in the ocean we also combine it with sunscreen applied to the skin.
Be inspired by these Weebly Women!


The SEMA Show is the premier automotive specialty products trade event in the world. It draws the industry's brightest minds and hottest products to one place, the Las Vegas Convention Center. As part of the AAIW, the SEMA Show attracts more than 100,000 industry leaders from over 100 countries for unlimited profit opportunities in the automotive, truck and SUV, and RV markets.


A New weekly show launches on cable channel as "UFC Tonight" aired at 10 pm EST on Tuesday. And for the first episode, the show featured UFC president Dana White as its first in-studio guest. Dana White offered an insider's perspective on the fights from UFC 141: Lesnar vs Overeem, a preview of upcoming events and the future of the UFC 2012 and beyond.
The Uncut Sports Show uncensored coverage of the NFL, MMA, NBA, MLB, NHL, NCAA, and every other sport and championships. The number one website delivering videos & coverage of Fighting videos, fighting championships, Fights Videos & championships online.