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Lion Capital, Goode Partners Acquire AllSaints
Investors rescue ailing British retailer.
By Samantha Conti on May 5, 2011
from WWD issue	05/06/2011 Download PDF
LONDON — After months of negotiations and stalled talks, the troubled British retailer AllSaints has finally found investors.
This story first appeared in the May 6, 2011 issue of WWD. Subscribe Today.
Lion Capital and Goode Partners said Thursday they had acquired AllSaints, which ran into trouble due to a rapid-fire retail rollout and the collapse of its Icelandic investors.
While Lion and Goode did not clarify the terms of their investment, an industry source said AllSaints was valued at about 105 million pounds, or $173.3 million. The source said Lion would have a 65 percent stake, Goode an 11 percent one, and top management a combined 24 percent.
"We are very excited to invest in a brand with such enormous potential," said Lyndon Lea, one of the founding partners of Lion Capital.
David Oddi, who founded Goode, said his group was "looking forward to leveraging our expertise to help the management team take this business to the next level."
Lion Capital's current investments include American Apparel Inc. and British lingerie brand La Senza, while Goode Partners has a stake in Intermix and the American retailer Luxury Optical Holdings.
Lion and Goode had been working on the deal for the past few weeks. Goode had been working for a while to get a deal off the ground, only to see its former partner, MSD Capital, Michael Dell's private investment fund, pull out last month.
AllSaints has been forced to restructure following the nationalization of the Icelandic bank Kaupthing, which held a majority stake in the company, and was looking to cash in on some of its investments. That stake had automatically passed to Kaupthing after AllSaints' original investor, Baugur, filed for bankruptcy in 2009.
Ernst & Young, which put Kaupthing's U.K. division into administration, the U.K. equivalent of Chapter 11, had been charged with finding new investors for AllSaints. The brand would have fallen into administration had it not found an investor.


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"Everyone should be a feminist" - Round Square International Youth Day Conference
Thursday, 25 Nov 2021
Students Rataj Abdullah, Betty Tesfamariam and Mikal Tesfamariam recently represented BDC at the Round Square International Youth Day Conference, entitled, "Everybody should be a feminist".
They represented BDC in discussions with students from Uganda, Ghana, Japan, India and the United Arab Emirates, over the 5 hour conference on Saturday evening.
Round Square said of the theme: "In today's world under the covers of the simple eight letter word FEMINISM lies a vast expanse of personal derivations. Feminism is for everybody and anyone who recognises the equality and full humanity of women and men, is a feminist.
"We aim to provide a platform youth from all over the globe to represent their views and perceptions on feminism and help eradicate the myths associated with it."
At the end of the conference, the ideas from individuals were combined, and represented. Here's our students' take on feminism:
Congratulations to these students for representing BDC and being wonderful role models for your peers, your families and the college.
Principal, Nick Johnstone, also reflected on what feminism means to him: "Feminism is about closing the gap in all areas of society around the world so that women have equal rights and then opportunities."

redpajama_set_name: RedPajamaCommonCrawl


If innovation was not our DNA, Safilin would not be what it is today. Since 200 years, we know that if we don't move foward, we decline... Our research activity is based on three major pillars: We are attentive. We anticipate. And we develop partnerships.
With over 100 years of experience, our priority for innovation is key for adapting to market developments and to our clients' evolution. In an ancestral industry such as textile, there are always solutions to invent, as shown by our yarn innovations signed "Flax Lab".
Our special knitting yarn is one of our Flax Lab's most important innovations: a yarn with unique performance and yield amongst linen solutions.
It can be used for flat and circular knitting, creating a light, comfortable fabric which combines the cool property of linen and the noncreasing property of knitted material.
Specially developed for the furnishing sector and demanding customers, the 80/20 LGAMILYS yarn combines the strength of linen with the endurance of polyamide. It is ideal for technical applications where durability is a priority and improves the abrasion resistance of your furnishing fabrics by up to 300%.
The latest arrival in the SAFILIN range, our stretch linen yarn was developed in Italy and patented by the company ELASTEN to meet strategic innovations in the use of linen for denim. This unique yarn is the result of an innovative patented process which opens the thread to incorporate elastane.
Compatible with all our yarns, it can be customized. This innovative process guarantees a more resistant and longer lasting yarn. We are currently working on many inventions for the future textile industry..
Our R&D laboratory constantly studies flax fibers and their unique properties, such as reinforcement for composite materials.
Up to twice as absorbent compared to glass and three-times more to carbon*.
Up to 15% better absorption compared to glass*.
15% less permittivity for 17% signal attenuation and 10% more velocity than glass composites.
We have many projects underway: internally with the constant improvement and development of our products; and in partnership with the automotive, rail and wind turbine industries, just to mention a few.
CULTURE IN: FLAX FIBER SERVING INTERIOR DESIGN!
We are partners with the company CULTURE IN, a French startup which created VARIAN®.
Between texture and structure, VARIAN® is a rigid impregnated fabric which is customisable, easy and ready to use, and entirely bio-based. A real textile sheet made of flax, it combines technical sophistication and aesthetics for the eco-design, layout and decoration of healthy and elegant living spaces.
VARIAN®meets the requirements of the industrial sector, combining comfort and technical performance with respect for the environment for living spaces for boats, planes and trains.
Safilin worked with INNOBAT, a startup in the French department of Hérault which developed a biomaterial for the fabrication of frames using the pultrusion process for the reinforcement of window profiles.
With interesting qualities, such as the same insulation capacity as PVC, the same mechanical resistance as aluminium and fully biobased, the products reduces the environment impact.
Safilin is also part of the adventure led by KAIROS, designer of the Gwalaz concept boat.
KAIROS worked closely with the TRICAT shipyard to build the 23.5 model, launched on 28 May 2013. Laboratory tests with IFREMER Brest, supported by the University of Bretagne Sud, confirmed the possibility to replace standard composites such as fibreglass and PVC core with biobased materials, such as flax fibers, cork, balsa wood and a resin containing 30% plant molecules.
The region of Brittany funded the unique prototype as part of its eco-innovation program. Gwalaz was used by the Breton Lost in the Swell team. After Barravel and Des Ile Usions, Ronan Gladu, Aurélien Jacob and Ewenn Le Goff navigated from island to island exploring new waves, the coastline and meeting local residents.
In 2017, Gwalaz was modified for the addition of the prototype of an innovative propulsion wing for the reduction of fuel by transport craft.
Thanks to its unique properties, flax fiber is used in many technical and industrial applications, quite distinct from its traditional use in textiles. We work with our customers constantly to meet their specific requirements. As a result, we develop numerous applications in a range of sectors. Paintable wallcovering, conveyor belts, baking equipment, automotive textiles... just some of the subjects we are investigating.
Meeting existing requirements is important, but we also strive to anticipate future requirements.
Our research center is capable to detect the potential in flax fiber for new, and often unimaginable, applications. Our knowledge base is vast, and we adjust our research with fine precision.
This exclusive expertise is a bonus when it comes to imagining new applications in diverse sectors.
At Safilin, we build long-term relationships with our clients, getting involved in ambitious projects. Whether it be as a partner or as a contributor, we put our expertise in complex environments.


The Template Attribute Language is an Attribute Languages used to create dynamic templates. By marking elements of your HTML or XML document with TAL statement attributes, you can replace parts of the document with dynamically computed content. You can insert text or portions of other documents, repeat elements such as list tags or table rows, or choose whether or not to include optional parts.
See TAL Reference for the current implementation specification.
See Proposed Changes for discussion of the next TAL specification.
Error Handling proposals exist in Error Handling Strategies.


This question should apply to anyone one with the automatic awning. I picked up my motor home on 6/28 and was told during the walk through that because of the curved side wall the awning may require a push with the hand when attempting to opening it. So far every time I open the awning I have to give it a push at the same time I'm pushing the awning button, otherwise it gets stuck a few inches from it's normal closed position and starts to unroll. I have to then roll it back in and make sure I give it a push as it starts to deploy and then its fine.
Anyone having this issue? The way it was explained to me it sounded like this may be a common issue. I don't recall this in the brochure or being talked about in any of their videos.
I have a 2017 2552 and have never had to even look sideways at the awning, runs in and out without a hitch. Maybe yours needs some adjustment?
On my 2016 2552 I frequently have to give it a little nudge to get it past top dead center (vertical) when it will unfurl on it's own. If we anticipate rain we will level with the driver side being slightly low so that water on the slide will run away rather than toward the coach. By doing this it hinders the awning a little more from self unrolling requiring the nudge to get it started.
I am not sure where you awning switch is located on the 2910 but on the 2552 it is convenient to actuate the switch and at the same time give the little nudge to get it over past vertical. Earl mentioned that when we picked up our unit and it is now just my standard routine and not a problem. I also believe the slope of the PC side walls by not being vertical causes this rather than an awning adjustment problem.
Yep. . .we mostly have to do the same with our 2012 PC2400 Sprinter. I wasn't sure if I was the only one who had this happen, but now I know it isn't too uncommon. Sometimes our awning will deploy properly without a nudge. . .I think our stored position is just at the vertical. It could be that if we are slightly low on the passenger side, the awning will open on its own, the laws of physics being what they are.
Same with us. Sometimes it rolls out without help and sometimes not. I watch while I hold the switch and just reach up and nudge it. I don't roll it back in first but since I'm watching, it doesn't unroll much before I push it. We hear the metallic "pop" as the awning bars release from the railings mounted to the rig so I think that tension holding the bars is what causes it.
Same thing with our "old" 2016 2351 and also with our two day old 2552. Just the way it is.
Mine hangs up on the front side, and makes a clunking sound when it breaks loose. Never needed any assistance. Tried to see what the difference is between front and back, but so far not seeing it..
Thank you all for your input, I appreciate it.
Well, really? This thread disappoints me..... over $100K and the awnings don't work right? I think I'll ask about a different brand or have one installed elsewhere after buying.
Phoenix used to install the manual crank-open box awning until around 2009, maybe 2010. We have the box awning of which is still offered on other motor homes and travel trailers today. It is used most often on entry level rigs because of it's affordability. Our box awning doesn't compare to the ease of opening and closing of the current-day motorized one, especially considering the hassle we deal with messing with our self-storing swing-arm-poles. But it is clean when stored-away. We have no vertical tracks, just the awning above in a stylish box. The long crank handle is stored in the entry door jamb, clipped into place. I cannot say our box awning is better or worse. Each awning has it's pros and cons......much the same argument in having a slide out or not.
Here is our box awning.
We often open it a foot or so without the poles without a fuss to offer rain protection and some sun-shade across the passenger side windows and door. There is a limit as to how far it open without poles because the more you open it, the lower it sags to the point of interfering with the swing of the entry door.
Bob at PC put a foam block somewhere in the support channel to not allow the awning to close so tightly and did help for a few uses but we're back to pushing it out. Price we pay for curved sidewalls and not so boxy look.
Interesting remedy, even if only for a few times. I wonder if the manufacture of the awning offers a spring or something as a permanent solution. It seems worth a call to ask.
We were advised that to open the awning we need to move one arm out slightly and that has always worked. Unless you are tilting to passengers side it does not move out on it own. It works well and is a big awning so it gives a nice shade. The light string under it is a blessing in a lot of parks which have little or no outside light.
We ordered our 2350 without an awning due to the large arms that were going to interfere with our rear swing storage/BBQ box. We will put an awning on like yours. Can you tell us the manufacture and model, and length? I'm also curious can the legs be lowered to accommodate harsher weather, and can the awning function partially extended(other than your picture)?


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Guidance for Industry: Pyrogen and Endotoxins Testing: Questions and Answers
Guidance for Industry: Pyrogen and Endotoxins Testing: Questions and Answers June 2012
Guidance for Industry
Pyrogen and Endotoxins Testing:
Center for Drug Evaluation and Research (CDER)
Center for Biologics Evaluation and Research (CBER)
Center for Veterinary Medicine (CVM)
Center for Devices and Radiological Health (CDRH)
Office of Regulatory Affairs (ORA)
Additional copies are available from:
Office of Communications, Division of Drug Information, WO51, Room 2201
10903 New Hampshire Ave., Silver Spring, MD 20993
Phone: 301-796-3400; Fax: 301-847-8714
druginfo@fda.hhs.gov
http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm
Office of Communication, Outreach and Development, HFM-40
Center for Biologics Evaluation and Research, Food and Drug Administration
1401 Rockville Pike, Rockville, MD 20852-1448
ocod@fda.hhs.gov
http://www.fda.gov/BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/default.htm
(Tel) 800-835-4709 or 301-827-1800
Office of Communication and Education
Division of Industry and Consumer Education
Center for Devices and Radiological Health; Food and Drug Administration
10903 New Hampshire Ave., WO66, Silver Spring, MD 20993
http://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/default.htm
Email: dice@cdrh.fda.gov
(Tel) Manufacturers Assistance: 800.638.2041 or 301.796.7100, International Staff Phone: 301.796.5708
Communications Staff, HFV-12
Center for Veterinary Medicine; Food and Drug Administration
7519 Standish Place, Rockville, MD 20855
http://www.fda.gov/AnimalVeterinary/GuidanceComplianceEnforcement/GuidanceforIndustry/default.htm
II. BACKGROUND
III. QUESTIONS AND ANSWERS
1. How do I establish a sampling plan for in-process testing and finished product release?
2. When is retesting appropriate?
3. Is sample storage and handling important?
4. Can finished product samples for analysis of bacterial endotoxins be pooled into a composite sample prior to analysis?
5. May a firm use alternative assays to those in the USP for a compendial article?
6. What is the best process for transitioning from one alternate bacterial endotoxins test (BET) method to another?
7. What happened to the endotoxins limit table in Appendix E of the 1987 Guidance?
8. How can Quality by Design concepts support endotoxins limits?
9. When is the USP Chapter Pyrogenicity Test (the rabbit pyrogen test) appropriate? 151>
10. How would an appropriate endotoxins limit be determined for a veterinary product that targets multiple species?
11. What are the endotoxins limits for medical devices?
12. What is the FDA's expectation for regular screening of therapeutic drug products?
13. Are control standard endotoxins still acceptable for use in running BETs?
Guidance for Industry [1]
Pyrogen and Endotoxins Testing —
This guidance represents the Food and Drug Administration's (FDA's) current thinking on this topic. It does not create or confer any rights for or on any person and does not operate to bind FDA or the public. You can use an alternative approach if the approach satisfies the requirements of the applicable statutes and regulations. If you want to discuss an alternative approach, contact the FDA staff responsible for implementing this guidance. If you cannot identify the appropriate FDA staff, call the appropriate number listed on the title page of this guidance.
This guidance provides recommendations for biological product, drug, and device firms on FDA's current thinking concerning the testing recommendations and acceptance criteria in the United States Pharmacopeia (USP) Chapter Bacterial Endotoxins Test,[2] USP Chapter Transfusion and Infusion Assemblies and Similar Medical Devices161>,[3] and the Association for the Advancement of Medical Instrumentation (AAMI) ST72:2002/R2010, Bacterial Endotoxins—Test Methodologies, Routine Monitoring, and Alternatives to Batch Testing(AAMI ST72).[4],[5] These three documents describe the fundamental principles of the gel clot, photometric, and kinetic test methods, and recommend that appropriate components and finished products be tested for the presence of pyrogens and endotoxins. 85>
This guidance does not cover the entire subject of pyrogen and endotoxins testing. Instead, it addresses those issues that may be subject to misinterpretation and are not covered in compendial procedures or in currently available guidance documents. You should already have a thorough understanding of these documents when using this guidance.
FDA's guidance documents, including this guidance, do not establish legally enforceable responsibilities. Instead, guidances describe the Agency's current thinking on a topic and should be viewed only as recommendations, unless specific regulatory or statutory requirements are cited. The use of the word should in Agency guidances means that something is suggested or recommended, but not required.
For more than 30 years, FDA has accepted the use of a Limulus Amoebocyte Lysate (LAL) test for endotoxins in lieu of the rabbit pyrogens test. In a November 4, 1977, Federal Register notice (42 FR 57749), FDA described conditions for using LAL as a finished product test.[6] By 1983, FDA indicated in guidance that an LAL test could be used as a finished product test for endotoxins. These tests were described in a series of draft and final guidance documents. The last guidance document, Guideline on Validation of the Limulus Amebocyte Lysate Test as an End-Product Endotoxin Test for Human and Animal Parenteral Drugs, Biological Products, and Medical Devices, was published in 1987 (the 1987 Guidance).
FDA has found that the published USP and AAMI documents describing methods and calculation of pyrogen and endotoxins testing limits[7] provide industry with appropriate information. We also note the continued development of USP Chapters and and FDA guidance documents. The Agency has withdrawn the 1987 Guidance because it no longer reflects the Agency's current thinking on the topic. However, because the compendial chapters and standards do not address certain regulatory perspectives, FDA is providing supplemental information in this guidance to explain our current thinking regarding the submission and maintenance of pyrogen and endotoxins testing for FDA-regulated products. 161>85>
The current good manufacturing practice (CGMP) regulations for finished pharmaceuticals and the medical device quality system regulations require development of controls that include scientifically sound and appropriate sampling plans.[8],[9]
Sampling plan information is addressed in AAMI ST72, but not USP Chapter . Firms should include a sampling plan as part of their application documentation. In the sampling plan, firms should consider the potential for contamination in raw materials, in-process materials, and the finished product. Specifically, firms should take into account aspects of the manufacturing design, including consistency of a manufacturing process, impact of in-process hold times, endotoxins removal steps, and finished product endotoxins specifications. The sampling plan should be considered dynamic; firms should begin with maximum coverage and adjust their sampling plans as they gain confidence in the prevention of endotoxins in their manufacturing processes. Firms should update their regulatory filings when adjusting sampling plans. For drugs and biological products, in-process changes to sampling plans are annual reportable changes.[10] For devices, a 30-day notice[11] may be appropriate for in-process changes to the sampling plan.[12]85>
When conflicting results occur within a test run, firms should consult USP Chapter , Gel Clot Limits Test, Interpretation, for guidance on repeat testing. As specified in Chapter , if the test failure occurred at less than the maximum valid dilution (MVD), the test should be repeated using a greater dilution not exceeding the MVD. A record of this failure should be included in the laboratory results. If a test is performed at the MVD and an out-of-specification (OOS) test result occurs that cannot be attributed to testing error, the lot should be rejected. [13] All testing procedures, including those for retesting within the above limits, should be specified in advance in written standard operating procedures approved by the firm's quality control unit. 85>85>
Yes. The ability to detect endotoxins can be affected by storage and handling. Firms should establish procedures for storing and handling (which includes product mixing) samples for bacterial endotoxins analysis using laboratory data that demonstrate the stability of assayable endotoxins content. Protocols should consider the source of
endotoxins used in the study, bearing in mind that purified bacterial endotoxins might react differently from native sources of endotoxins.
Yes. With some exceptions (see below), finished drug product units may be pooled into a composite sample and assayed for bacterial endotoxins. The composite sample may be represented by the entire unit or partial aliquots (equal volumes) of finished product containers from one manufactured lot of aqueous-based pharmaceuticals. Pooling would generally be accepted for small-volume parenterals (those with volumes of 100 mL or less) as long as the MVD is adjusted to a proportional, lower value because of the potential for diluting a unit containing harmful levels of endotoxins with other units containing lower, less harmful, levels of endotoxins. This "adjusted MVD" is obtained by dividing the MVD computed for an individual sample by the total number of samples to be pooled. FDA suggests pooling no more than three units per composite in keeping with the concept of testing representative beginning, middle, and end finished product containers. If this reduction in MVD results in an inability to overcome product-related assay interference because of an insufficient dilution, then the samples should be tested individually.
Finished medical devices may also be pooled into a composite sample and assayed for bacterial endotoxins. Testing for medical devices should be conducted using rinsing/eluting and sampling techniques as described in ISO 10993-1[14] and ISO 10993-12,[15] as also used for inhibition/enhancement. Sampling can be adjusted for special situations. After a suitable eluate/extract pool is obtained from a finished production lot, this pooled extract should be kept under conditions appropriate for stability until it is tested in duplicate.
FDA recommends that pooled samples be a composite of aseptically removed aliquots (after at least 30 seconds of vigorous mixing) from each of the product containers.[16] In this way, the original, individual containers will be available for possible retesting in the event the pooled sample displays an OOS result.
Some product types should not be pooled. Two examples are drug products that have an initial low MVD (see discussion above of "adjusted MVD") and products that are manufactured as a suspension, because sample aliquot homogeneity may present significant interference issues. FDA also does not recommend pooling in-process samples from different in-process stages of the manufacturing process because it may be difficult to ensure the homogeneity of these materials.
Yes, firms may use alternative methods and/or procedures if they provide advantages in terms of accuracy, sensitivity, precision, selectivity, or adaptability to automation or computerized data reduction, and in other special circumstances. Such alternative procedures and methods should be validated as described in the USP General Chapter , Validation of Compendial Procedures,[17],[18] and should be shown to achieve equivalent or better results.[19] When a difference appears or in the event of a dispute, the final decision is made based upon the USP compendial gel clot method unless otherwise indicated in the monograph for the product being tested.[20]1225>
Below are two examples of alternative assays.
(1) Recombinant Horseshoe Crab Factor C Assay
If a manufacturer chooses to use a recombinant factor C-based assay, then method validation should be in accordance with the requirements of USP Chapter , Bacterial Endotoxins Test, as described in the section for Photometric Quantitative Techniques, and USP Chapter , Validation of Compendial Procedures. [21]1225>85>
(2) Monocyte Activation Type Pyrogen Test
Product-specific validation is necessary to establish whether a particular test substance or material is appropriate for evaluation of the monocyte activation method. The validation should include, but is not limited to, interference testing, accurate detection of pyrogen in individual test samples, and, for devices, ability of test system to provide direct contact to the monocytes.
The transition between tests that measure the same entity (e.g., LAL cascade) can be made by comparing the two tests to verify the equivalence of the new method. [22] The comparison of the limit of detection and inhibition/enhancement is fundamental. The sensitivity of the new method can be evaluated on spiked product samples. [23] In addition to using spiked samples, a battery of field samples of product found to be positive may be a good source for comparing results from the methods. The method validation should also attempt to address the variability found in the normal use of the method and the manufacturing environment (e.g., source materials or seasonal changes). [24]
For drug, animal drug, and biological products, the transition to a new method should be submitted in a prior approval supplement (PAS). Alternatively, once a firm has established a general method for making the transition between tests, it may submit the method for review in a PAS—comparability protocol (CP). The CP should describe, in detail, the methods used to transition between assays and the acceptance criteria used to establish the equivalence of the new method. After approval of the CP, results of implementation of the CP may be directed to be reported in a reduced reporting category (Supplement—Changes Being Effected or Annual Report or Special Report (21 CFR 314.80)). The firm should maintain the study protocol, final report, and all data at the facility for FDA review. The firm should confirm the filing process with the appropriate review division before submitting a CP. For Class III devices, the transition to a new assay requires a 30-day notice filed under 21 CFR 814.39(e). See FDA's guidance, Modifications to Devices Subject to Premarket Approval (PMA) - The PMA Supplement Decision-Making Process, http://www.fda.gov/downloads/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/UCM089360.pdf. Manufacturing changes for Class I and II devices should be in accordance with the quality system regulation, 21 CFR part 820. Design control, production and process control requirements can be found at 21 CFR 820.30, 21 CFR 820.70, 21 CFR 820.72, and 21 CFR 820.75.
For devices, a 30-day notice may be appropriate for changes to quality control testing used on incoming components, raw materials, the in-process device, or the finished device, including performing end-product pyrogen testing on nonsterile samples prior to sterilization. [25] Manufactures of medical devices should demonstrate a sensitivity that is consistent with the route of administration for the device and the type of body contact. Manufacturers may use another endotoxin test after demonstrating a reproducible correlation between methods and the USP reference standard.
The endotoxins limit table is out of date due to the increase in numbers of dosage (regimes) and drug strengths since the publication of the 1987 Guidance. The appropriate
way to establish the endotoxins limit is to use the calculation methods provided in the USP or AAMI standards. Monograph limits may also not account for current product strengths or dosage regimes; these should also be checked using the calculations recommended in the standards.
If there are several components in a finished product, then the overall endotoxins limit for parenterally-administered products should not exceed the overall threshold limit specified in the USP Bacterial Endotoxins Test, regardless of an individual component endotoxins limit. Intrathecally-administered products, ophthalmics, or devices (see question 11 for devices) may have endotoxins limit requirements that are not based on the calculation for parenterally administered products. FDA encourages firms to check with the appropriate office or review division about these products.85>
8. How can Quality by Design concepts support endotoxins limits? [26]
[26
When implementing Quality by Design concepts, the strategy for endotoxins testing should be based upon product and process understanding in combination with risk management to ensure consistent final product quality. The appropriate in-process testing should be used to evaluate the production process areas at risk of endotoxins formation or incursion. Many firms already have programs for monitoring incoming ingredients and components, including the processing water, for endotoxins contamination. The finished product release specification should be considered when determining in-process limits for each phase of manufacturing tested. For purposes of evaluating the relative risk of product contamination, quantitative testing may be preferable to limit testing to facilitate product quality trending and to identify and correct excursions before they exceed the specification and cause product failure. An endotoxins limit should be justified on a case-by-case basis, and will be evaluated as a part of each relevant marketing application or supplement.
9. When is the USP Chapter Pyrogenicity Test (the rabbit pyrogen test) appropriate?151>
For certain biological products, 21 CFR 610.13(b) requires a rabbit pyrogen test. The requirement in 21 CFR 610.13(b) may be waived if a method equivalent to the rabbit pyrogen test is demonstrated in accordance with 21 CFR 610.9.
For human and animal drugs, some USP monographs still require a rabbit pyrogen test. Even with such monographs, a firm may substitute an endotoxins test or alternative cell-based test if the firm can demonstrate equivalent pyrogen detection. The appropriate FDA review division will consider alternative methods, such as monocyte activation, on a case-by-case basis.
For devices and drug materials, firms should assess the risk of the presence of non-endotoxin pyrogens. If the risk assessment indicates that non-endotoxin pyrogens may be present, it may be more appropriate to use the rabbit pyrogen test.
Bacterial endotoxins assays are subject to a variety of interferences related to the physical and chemical properties of the test article. Where such interferences cannot be mitigated through sample dilution (up to the MVD) or other validated means of sample preparation, firms should use the rabbit pyrogen test.
For a veterinary product labeled for use in multiple species, the limit should be based on the maximum product dose used on the smallest species. If the label indicates that the product may be used on juvenile and adult animals, the juvenile is considered the worst case. If the weight of the animal is required to calculate the dose, firms should use an average weight for that species. For a listing of some average animal weights, see the FDA draft guidance for industry on Waivers of In Vivo Demonstration of Bioequivalence of Animal Drugs in Soluble Powder Oral Dosage Form Products and Type A Medicated Articles. For animal weights not listed in that guidance, please contact FDA's Center for Veterinary Medicine.
The Center for Devices and Radiological Health (CDRH) has adopted the USP Endotoxin Reference Standard and limits for medical device extracts expressed in EU/mL. USP Chapter Transfusion and Infusion Assemblies and Similar Medical Devices provides the limits for medical devices within its scope. The endotoxins limit for a medical device is dependent on the intended use of the device and what the device contacts (e.g., blood, the cardiovascular system, cerebrospinal fluid, intrathecal routes of administration, permanently implanted devices, and devices implanted subcutaneously).[27]161>
For medical devices, using the extraction volume recommendations described below, the limit is 0.5 EU/mL or 20 EU/device for products that directly or indirectly contact the cardiovascular system and lymphatic system. For devices in contact with cerebrospinal fluid, the limit is 0.06 EU/mL or 2.15 EU/device. For devices that are in direct or indirect contact with the intraocular environment, a lower endotoxins limit may apply. Please contact the appropriate review division for specific recommendations.
The process of preparing an eluate/extract for testing may vary from device to device. Some medical devices can be flushed, some may have to be immersed, while others may need disassembly. Unless otherwise directed by another compendial standard, our recommended rinse volumes include the following: (1) each of the 10 test units should be rinsed with 40 mL of non-pyrogenic water; (2) for unusually small or large devices, the surface area of the device that contacts the patient may be used as an adjustment factor in selecting the rinse or extract volume. The endotoxins limit can be adjusted accordingly. In any case, the rinse/extract procedure should not result in a greater dilution of endotoxin than recommended in USP . For inhibition/enhancement testing, both the rinse/extract solution and the device eluate/extract should be tested.85>
Examples of medical devices with testing or interference challenges include devices that are coated with anticoagulant, contain heavy metals, or that have particulates. In these situations, treatments for interferences can include digestion, dilution, and addition of buffers, centrifugation, or filtration.
During the same surgical procedure or placement in the same surgical site, multiple units of the same device from one manufacturer should generally meet the same endotoxins limit as a single device administered during the procedure. In instances where multiple units of the same device are known or intended for use in a single procedure, manufacturers should justify any deviation from the overall endotoxins limit identified in this guidance.
When a manufacturer of medical devices plans to use LAL testing that deviates significantly from this guidance or recognized standard, a premarket notification (510(k)) under section 510(k) of the Federal Food, Drug, and Cosmetic Act (the Act) or a premarket approval application (PMA) supplement under section 515 of the Act should be submitted. Significant deviations include, but are not necessarily limited to: higher endotoxin concentration release criteria, sampling from fewer than three (3) lots for inhibition/enhancement testing, lesser sensitivity to endotoxins, and a device rinsing protocol resulting in greater dilution of endotoxins than that recommended in this guidance.
Ideally, the undiluted product should be screened as long as there is no interfering/enhancing property within the LAL test. However, in some product formulations, the ingredients interfere with the LAL test. For such formulations, the USP recommends that the product be diluted to overcome interference or enhancement properties. The calculated MVD is the dilution of a sample at which the endotoxins limit would be detected, but it should not be the regular testing dilution. When product interference is encountered during development, FDA recommends that the firm determine the lowest product dilution that would neutralize the interfering condition.
FDA recommends that firms begin subsequent product screening at a product dilution just above the level that neutralized the interference. For example, if the product has an MVD of 1:100, and the product displays inhibition at the 1:10, but not at the 1:20, it may be best to screen product at 1:30. If bacterial endotoxins are detected at this level, then the firm should conduct full enumeration with the product to titrate the true amount of endotoxins.
13. Are control standard endotoxins still acceptable for use in running bacterial endotoxins tests?
Control standard endotoxins (CSEs) are endotoxin preparations other than the international or national reference standards that are traceable in their calibration to the international reference endotoxins standard. CSEs may be secondary or tertiary standards and are usually manufactured and certified by an LAL reagent manufacturer for use with a specific lot of reagent under defined assay conditions. CSEs have become an accepted source for preparation of standard curve calibrators and as assay controls, and have provided a cost saving to LAL users and helped to preserve the inventory of primary standards. FDA encourages the continued use of CSEs that are suitably calibrated to the international reference endotoxins standard.
[1] This guidance has been prepared by the Division of Manufacturing and Product Quality, Office of Compliance, in the Center for Drug Evaluation and Research (CDER) in cooperation with the Center for Biologics Evaluation and Research (CBER), the Center for Veterinary Medicine (CVM), the Center for Devices and Radiological Health (CDRH), and the Office of Regulatory Affairs (ORA) at the Food and Drug Administration.
[2] United States Pharmacopeia (USP), 2011, Chapter , Bacterial Endotoxins Test. 85>
[3] USP, 2011, Chapter , Transfusion and Infusion Assemblies and Similar Medical Devices. 161>
[4] Association for the Advancement of Medical Instrumentation (AAMI), 2002/R2010, Bacterial Endotoxins — Test Methodologies, Routine Monitoring, and Alternative to Batch Testing.
[5] Veterinary drug requirements parallel the human drug requirements in safety evaluation for pyrogenicity (21 CFR 514.1(b)(5)(v), and 514.1(b)(5)(vii)(b)).
[6] "Licensing of Limulus Amebocyte Lysate, Use as an Alternative for Rabbit Pyrogen Test" (42 FR 57749, November 4, 1977).
[7] USP, 2011, Chapter , Bacterial Endotoxins Test; USP, 2011, Chapter , Transfusion and Infusion Assemblies and Similar Medical Devices, Association for the Advancement of Medical Instrumentation (AAMI), 2002/R2010, Bacterial Endotoxins—Test Methodologies, Routine Monitoring, and Alternatives to Batch Testing. 161>85>
[8] See 21 CFR 211.160.
[9] See 21 CFR 820.70, and 21 CFR 820.250.
[10] See 21 CFR 314.81(b)(2)(iv).
[11] 21 CFR 814.39(f).
[12] For guidance regarding when and how to submit a 30-day notice, please refer to the FDA Guidance for Industry and FDA Staff; 30-Day Notices, 135-Day Premarket Approval (PMA) Supplements, and 75-Day Humanitarian Device Exemption (HDE) Supplements for Manufacturing Method or Process Changes (issued April 13, 2011). http://www.fda.gov/downloads/MedicalDevices/DeviceRegulationandGuidance/GuidanceDocuments/UCM080194.pdf.
[13] For guidance regarding how to examine results that are above acceptable limits, please refer to the FDA guidance for industry on Investigating Out-of-Specification (OOS) Test Results for Pharmaceutical Production. Although this guidance is not intended to address biological assays, many of the concepts in the guidance are applicable to bacterial endotoxins testing. We update guidance documents periodically. To make sure you have the most recent version of a guidance, check the FDA Drugs guidance Web page at http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm
[14] ISO 10993-1:2009 Biological evaluation of medical devices Part 1: Evaluation and testing in the risk management process.
[15] ISO 10993-12:2007 Biological evaluation of medical devices Part 12: Sample preparation and reference materials.
[16] See 21 CFR 211.84(c)(3).
[17] USP, General Notices 6.30. Alternative and Harmonized Methods and Procedures.
[18] USP, 2011, Chapter , Validation of Compendial Procedures.1225>
[20] USP, 2011, Chapter , Bacterial Endotoxins Test.85>
[23] International Conference on Harmonisation (ICH) Q2(R1) Validation of Analytical Procedures: Text and Methodology (1994); USP, 2008, Chapter , Validation of Compendial Procedures.1225>
[24] Thompson, M. et al., 2002, "Harmonized Guidelines for Single-Laboratory Validation of Methods of Analysis: IUPAC Technical Report," Pure Appl. Chem., Vol. 74, No. 5, pp. 835-855.
[26] ICH Harmonised Tripartite Guideline, Q8(R2) Pharmaceutical Development, Step 4 Version (2009).
[27] USP, 2011, Chapter , Transfusion and Infusion Assemblies and Similar Medical Devices.161>
Submit comments on this guidance document electronically via docket ID: FDA-2013-S-0610 - Specific Electronic Submissions Intended For FDA's Dockets Management Staff (i.e., Citizen Petitions, Draft Proposed Guidance Documents, Variances, and other administrative record submissions)
All comments should be identified with the title of the guidance.


This is yet another innovative pattern from the bookcase industry- a bookcase with glass doors. These are designs that add modernity to functionality in bookcases. Bookcases usually display books in stacks with spines pointing outwards, however, some types of materials may require being kept away from unfavorable harsh conditions such as dust and moist. The creation of bookcases with doors and then those with glass doors will readily solve this problem.
A mix of wood and glass or metals and glass are often used in this pattern. Quite often, the glass is neatly fitted into the wood frame for the door positioning. The modern and contemporary design with metal is a clean match in many designs with cool finish of gray tone. Some might have engravings of alloys of bronze or brass metal to adorn the design.
There are different styles in this designs you can make your selection from.
A design of this pattern makes the opening by sliding one end of the door towards the other. This can be equipped with key locks to restrict access. They are design styles that depict the modern look and taste.
The reason for having a glass door bookcase like mentioned earlier can be both personal or for a decorative style that adds style to your home. If you have some items that you want to keep away, you can have a portion of the bookcase divided for that purpose. If on the other hand, you can have the whole bookcase all-glass depending on your style and storage demands required.


text:
Arroyo del Guique
Arroyo del Guique is a stream in New Mexico and has an elevation of 5676 feet. Arroyo del Guique is situated north of Pueblito, close to RG-32374 Water Well.
Pueblito
Pueblito is an unincorporated community and census-designated place in Rio Arriba County, New Mexico, United States.
Chamita
Chamita is an unincorporated community and census-designated place in Rio Arriba County, New Mexico, United States. Chamita is situated 2 miles southwest of Arroyo del Guique.
Ohkay Owingeh
Ohkay Owingeh is a census-designated place in Rio Arriba County, New Mexico, United States and a federally recognized tribe of Native American Pueblo people. Ohkay Owingeh is situated 2½ miles south of Arroyo del Guique. Photo: Davidhc9, CC BY-SA 3.0.
Location: New Mexico, Southwest, United States, North America
36.0872° or 36° 5' 14.1" north
-106.0731° or 106° 4' 23.1" west
5676 feet (1730 metres)
GuiqueHamlet
AlcaldeHamlet
La VillitaHamlet, 2 miles northeast
EstacaHamlet, 2 miles northeast
Sebastian Martin Black Mesa Site Two DamDam, 2000 feet northwest
Sebastian Martin Black Mesa Site Three DamDam, 2500 feet northwest
Sebastian Martin Black Mesa Site One DamDam, 3400 feet southwest
Sebastian Martin Black Mesa Site Four DamDam, 1 mile north
RG-32374 Water WellWell, 570 feet west
Guique DitchCanal, 830 feet southwest
RG-32217 Water WellWell, 820 feet east
RG-6448 Water WellWell, 1300 feet northwest
Río NuevoStream, Guerrero, Mexico
Robertson RiverStream, British Columbia, Canada
Pohatcong CreekStream, Hunterdon County, New Jersey
Cotterell RiverStream, Queensland, Australia
Quebrada JaramilloStream, Panama
Sungai Uju UjuStream, Negeri Sembilan, Malaysia
Popular Destinations in New Mexico
North Central New Mexico Albuquerque
Santa Fe Southwest New Mexico
ArgentinaSouth America MerzougaMorocco
Lake District National ParkUnited Kingdom Santa TeresaCosta Rica
About Mapcarta. Thanks to Mapbox for providing amazing maps. Text is available under the CC BY-SA 4.0 license, excluding photos, directions and the map. Photo: Dschwen, CC BY-SA 3.0.


Roger Penske, the team owner with the most race wins and season championships in Indy car history, will be bestowed another honor in his legendary career when he is presented the 11th annual Simeone Foundation Automotive Museum Spirit of Competition Award in a ceremony Wednesday, Oct. 31 at the Philadelphia museum.
The prestigious award is given annually to "a distinguished figure from motorsports who has a specific inspirational message." Previous recipients include Mario Andretti, Janet Guthrie, Bobby Rahal and David Hobbs.
The list of Penske's motorsports achievements is lengthy outside of Indy car racing as well. He has also been a successful car owner in Formula 1, NASCAR, sports cars and Supercars in Australia.
Schmidt Peterson Motorsports is hosting its first-ever garage sale at the team's Indianapolis facility on Saturday, Nov. 3, with proceeds benefitting Conquer Paralysis Now, the nonprofit founded by team co-owner Sam Schmidt.
Among the items available will be car parts including bodywork, gears, springs and wheels, as well as team firesuits. Some items will be autographed by SPM driver James Hinchcliffe.
The sale runs from 9 a.m.-3 p.m. ET. Those attending are asked to bring non-perishable food items – such as coffee, pasta, oatmeal, cereal, canned fruit and vegetables, sugar, salt and pepper – that will be donated to a local food bank. The Schmidt Peterson Motorsports shop is located at 6803 Coffman Rd., Indianapolis, IN 46268.
Firestone Grand Prix of St. Petersburg: The exclusive renewal period to purchase tickets is now open for fans who attended this year's race on the streets of the Florida city. The 2019 St. Pete race weekend is scheduled for March 8-10 and will once again open the season schedule.
Customers who purchased three-day reserved seats for the 2018 event have until Nov. 5 to renew or upgrade their seats. General public sales begin at 10 a.m. ET Nov. 8.
Ticket prices again remain unchanged. Renewal customers who purchase three-day reserved seating receive automatic enrollment in the Champions Club when placing orders now through the 9 p.m. ET Nov. 5 deadline. New for 2019, Champions Club members will be granted unprecedented access to attend the IndyCar Series drivers meeting on race day morning. Additionally, the club offers exclusive benefits including a complimentary IndyCar Series paddock pass, access to the prerace grid walk and more.
Renewals are available online at gpstpete.com or by phone at 877-725-8849, with pricing starting at $105 for reserved grandstand seating.
Chevrolet Detroit Grand Prix presented by Lear: Tickets are on sale now for the race weekend at Detroit's Belle Isle Park that runs May 31-June 2, 2019. Fans may purchase tickets by visiting DetroitGP.com/Tickets or by calling 866-464-7749.
Tickets start as low as $45 and all include access to the INDYCAR paddock. Comerica Bank Free Prix Day allows free admission to everyone on Friday, May 31. Single-day tickets for Saturday and Sunday of race weekend start at $45 for general admission and $80 for two-day general admission. Children 12 and under are admitted into the general admission seating areas free of charge with a ticket-bearing adult; limit two children per adult.
Single-day Reserved Grandstand tickets start at $55 for the value-priced Grandstand 3 and $70 for Cars.com Grandstand 1 and City of Windsor Grandstand 2.
INDYCAR Grand Prix of Monterey: Tickets for the 2019 season finale at WeatherTech Raceway Laguna Seca go on sale at 11 a.m. ET Wednesday. The race weekend on the 2.238-mile permanent road course near Monterey, California, is set for Sept. 20-22.
General admission and paddock prices range from $25 for a single-day option on Friday to three-day tickets for $160. Preferred parking, VIP and Flagroom hospitality is also available, as well as premier and reserved camping opportunities. For more information and to purchase tickets, visit WeatherTechRaceway.com or call 831-242-8200 after 11 a.m. ET Wednesday.
Andretti Autosport driver Zach Veach, fresh off his rookie season in the Verizon IndyCar Series, will be the featured guest on Oct. 26 for "Fuel Up Fridays" at the Indianapolis Motor Speedway Museum.
The event gives IMS Museum members an opportunity to learn more about racing personalities in an intimate setting, through a one-hour question-and-answer session hosted by IMS historian Donald Davidson. The session runs from 8-9 a.m. ET and includes complimentary coffee, donuts and pastries.
IMS Museum members may RSVP by contacting Kelly Hartman at 317-492-6568 or khartman@brickyard.com. IMS Museum membership information is available by contacting Hartman or visiting indyracingmuseum.org.


text:
Home Opinion Editorial
We don't need 6 more bloody years
in Editorial
Months after President Duterte declared he would be happy to go to jail for ordering the killing of human rights activists and communists, an international watchdog group released its second of three reports documenting the "intensifying political repression" and the continuing human rights violations in the Philippines.
In its second report (the first was released in March), the Independent International Commission of Investigation Into Human Rights Violations in the Philippines (Investigate PH) said state-driven political violence continues to escalate, and focused on three aspects of this: 1) a war on the poor in the guise of anti-drug operations; 2) a war on dissent; and 3) a war on the Moro people.
Relying on testimonies and verified information from resource persons who include survivors, relatives of victims and human rights advocates, an expert witness on autopsies, and court records, Investigate PH found the Philippine National Police (PNP) continues to obstruct justice, routinely covering up the circumstances of killings in the war on drugs, and intimidating families and potential witnesses.
The report indicated that unarmed victims were killed inside their homes, on the street or on being abducted. Weapons or narcotics were "likely planted after," the report also pointed out.
"Warrants are not required and individuals lack immediate and effective legal recourse to challenge their inclusion on target lists, undermining due process," the report said.
"Those killed in anti-drug operations are overwhelmingly poor people unable to assert their rights to due process," it added.
Investigate PH also said there was a lack of credible autopsies as proper procedures were ignored.
"Death Certificates lacked data and were inaccurate. The police examination did not include X-rays of victims, nor properly record evidence of defensive wounds," Investigate PH said.
"A number of the bodies showed evidence of zip ties or handcuffs, which indicates that the victims were restrained when they were executed," the report continued. It noted that Dr. Raquel Fortun, a professor of forensic pathology at UP, found that defensive wounds of victims were not recorded by the police.
Death certificates of drug war victims were also signed by doctors associated with the PNP. This means there could be cooperation with the medical professionals in the cover up of the extrajudicial killings, the report said.
The report also found that the armed forces are more emboldened in killing dissenters.
"Police and soldiers are now executing political dissenters in a manner similar to extrajudicial killings in anti-drug operations," the report said.
Duterte's National Task Force to End Local Communist Armed Conflict (NTF-ELCAD), the Anti-Terrorism Act, and increasingly the justice system have not only facilitated these killings, but are institutionalizing repression that harms civil society, from alleged communists to churches to long-standing democratic institutions, the report said.
Against this backdrop, the President's announced intention to run for vice president takes on an ominous tone indeed, with the prospect of six more bloody years but little to show for it. After all, he himself acknowledged back in 2019 that the administration's war on drugs was a failure—and his minions only recently said he had "unfinished business" when it comes to drugs and corruption.
We shudder at the prospect of how Mr. Duterte will try to finish this business in years to come.
Tags: human rights activistsInvestigate PHkillingPhilippine National PoliceRodrigo Duterte
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China on Tuesday launched the world's first quantum satellite, which will help it establish "hack-proof" communications between space and the ground, state media said, the latest advance in an ambitious space program.
"In its two-year mission, QUESS is designed to establish 'hack-proof' quantum communications by transmitting uncrackable keys from space to the ground," it said.
"Quantum communication boasts ultra-high security as a quantum photon can neither be separated nor duplicated," it added. "It is hence impossible to wiretap, intercept or crack the information transmitted through it."
The satellite will enable secure communications between Beijing and Urumqi, Xinhua said, referring to the capital of China's violence-prone far western region of Xinjiang, where the government says it is battling an Islamist insurgency.
"The newly-launched satellite marks a transition in China's role – from a follower in classic information technology development to one of the leaders guiding future achievements," Pan Jianwei, the project's chief scientist, told the agency.
Quantum communications holds "enormous prospects" in the field of defense, it added.


When you need to cleanse | repair | nourish sensitive and acne prone skin.
A versatile, soothing and natural cleansing balm that cleanses, repairs and nourishes the skin. Suitable for all skin types, in particular troubled acne prone skin.
Handmade using only the freshest ingredients, this multipurpose cleansing balm can also be used as a deep moisturiser, eye makeup remover and a lip balm.
Using 100% natural vegan ingredients to leave skin feeling deeply cleansed, nourished and soothed. With evening primrose extract to calm inflamed skin makes this balm suitable for acne prone skin too.
A unique blend of plant extracts, oils and butters, provides wonderful moisturising, rejuvenating and skin protecting properties perfect for achieving radiant and glowing skin.
Plum Kernel Oil to condition the skin and to provide a wonderful aroma.
Use as a cleansing balm by rubbing a small amount on to dry skin. Remove with a warm wet muslin cloth to leave skin feeling deeply cleansed and gently exfoliated. Use once or twice a day.
Use as an eye makeup remover by gently rubbing a small amount of balm over closed eyes. Remove with a warm wet muslin cloth or damp cotton wool pad.
Use as a lip balm: Apply a small amount of balm to dry lips as and when required.
As a moisturiser for dry skin areas such as elbows and heels: Rub a small amount of balm into the skin when deep moisturisation is required.
Delivery: I want you to receive the freshest product for your skin, which is why all the products are handmade to order. In some cases it may take between 7-10 days to despatch your order and when this occurs you will be kept informed. Here's 8 reasons why choosing freshly handmade is a good decision.
I love this. I use it to take off my makeup and as a moisturiser.
I'm really pleased you are loving the cleansing balm.


It was great to come out with the wind after a bumpy lead in. We had lots of small things and challenges that make a bit difference when you add them together. We had injuries, geographical logistics and they all add up. With regards to Rio. Four years is a long time and we are just working one week at a time.


text:
Seth Stammler est un footballeur américain, né le  à  Columbus, Ohio, États-Unis. Il évolue comme défenseur avec le club des Red Bull New York depuis 2004.

Clubs successifs
 2004-:  MetroStars/Red Bull New York

Liens externes

  Profil du joueur

Joueur américain de soccer
Joueur de soccer des Terrapins du Maryland
Joueur des Red Bulls de New York
Naissance à Columbus (Ohio)
Naissance en septembre 1981

redpajama_set_name: RedPajamaWikipedia


Rosa Thea FCI is a small, home kennel of chinese crested dogs located in Poland. We have occasionally puppies. Dogs used in our breeding programme are health checked: CERF clear, patella 0/0, heart checked clear, genetically prcd-PRA clear and genetically PLL (primary lens luxation) clear.


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text:
Monsenso is Nominated for Best HealthTech Startup by Nordic Startup Awards
Enterprise SaaS
The Baltics
Blog, Denmark, Entrepreneurs, News, Social entrepreneurship, The Nordic
by Taylor Ryan
Innovation House Finland is Nominated for Best Coworking Space by Nordic Startup Awards
It's Time to Take Mental Illnesses Seriously
Mental health has become a huge social burden and a problem that grows on a daily basis. According to Monsenso founders, it is a major reason for lower life quality. This problem is expected to become the largest burden in the early 2020s.
That's why Monsenso has developed an innovative mHealth solution with the goal to help optimize the treatment of mental disorders. The team wants to enable better mental health treatment to more people with the use of smartphone technology, giving them an option that costs much less than traditional solutions.
Monsenso Connects Individuals, Clinicians, and Carer
Founders Jakob E. Bardram, Ph. D., and Mads Frost, Ph.D., say that their mission is to help healthcare providers, researchers, and individuals overcome the burden of mental illness and empower individuals by helping them become more involved in their treatment.
Monsenso has developed a mHealth solution, which connects individuals, clinicians, and carers and optimizes possibility for self-care, informal care and formal care for people with mental illness. It allows subjective and objective data to flow from the individual to the clinician, giving the clinician a better overview of the patient's mental state, while allowing them to intervene early on and provide remote care. They explained.
Furthermore, carers can also take part in the treatment, while following the progress of their loved ones. The mHealth solution helps individuals self-manage their disorder by offering psycho educative content and helpful tools.
The solution consists of a smartphone app for individuals, an app for carers, and a web portal for all users. Clinicians also get data analytics reports which enable them to connect behavioral data to illness progression. The platform also provides feedback to individuals, through which they can monitor their advancements.
Future Plans in Denmark and the UK
Monsenso's main solution is offered as Software-as-a-Service (SaaS), for what the startup charges a subscription fee. They also offer consultancy for configuration, project management, and customization.
"Unconventional Accelerator": The first digital accelerator targeting underrepresented Nordic founders
The startup has received DKK 11 million from angel investors, DKK 18 million from soft grants, and a loan of DKK 4 million Vaekstfonden. They also receive R&D funding from participation in H2020 projects, Eurostars project, Danish Innovation Fund projects etc. With this funding, Monsenso will do research across Europe and expand its business with new commercial pilots in addiction and autism space in Denmark and UK.
Region South Denmark is one of Monsenso's most important customers. The region decided to use Monsenso's solution within its affective disorder and early intervention teams, in order to implement it in the treatments of depression, bipolar, schizophrenia, anxiety and borderline personality disorder.
Who is Valuer.ai? Valuer.ai is a Danish company that provides large corporations with the perfect matching innovative startups. As a partner of the Nordic Startup Awards, Valuer.ai has decided to write about nominees taking part in the award.
Taylor Ryan August 15, 2018
Nordic Startup Awards finalists announced
Insurance-tech had a record-breaking start in 2016
Kaffe Bueno is Nominated for Best FoodTech/AgriTech Startup by Nordic Startup Awards
Lawbotics is Nominated for Best Bootstrapped Startup by Nordic Startup Awards
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Deposition Author(s): Horton, J.R., Sawada, K., Nishibori, M., Zhang, X., Cheng, X.
Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons.
Horton, J.R., Sawada, K., Nishibori, M., Zhang, X., Cheng, X.
Histamine plays important biological roles in cell-to-cell communication; it is a mediator in allergic responses, a regulator of gastric acid secretion, a messenger in bronchial asthma, and a neurotransmitter in the central nervous system. Histamine acts by binding to histamine receptors, and its local action is terminated primarily by methylation. Human histamine N-methyltransferase (HNMT) has a common polymorphism at residue 105 that correlates with the high- (Thr) and low- (Ile) activity phenotypes.
Yan, L.,Galinsky, R.E.,Bernstein, J.A.,Liggett, S.B.,Weinshilboum, R.M.


Dobby panels and yarn-dyed fabric give this Cubavera shirt a tropical twist so you always get a taste of the good life. Alternating colors and slightly textured, vertical panels accent the dual-toned body color. A linen fabric blend creates a lightweight, breathable shirt. Plain weave fabrication features a hard-woven, criss-cross thread pattern and a classic fit finishes the shirt with a relaxed cut that's fuller through the chest and waist. This short sleeve button-down features a point collar.


Discussion in 'Installation/Configuration' started by acidh, Jan 6, 2008.
Have been running a production server for about 600 days know without any problems.
Since last friday, i've been getting strange problems with pop3 mail retrieval.
Since friday, i've had 2 clients that couldn't retrieve their e-mail, neither with Outlook 2003, Outlook 2007 or Outlook Express.
@ first i tought it where errors from the clientside, cause i googled the outlook error messages, and they all said client errors. But since 2 different clients with two different ISP providers got the same errors, spread over 3 days, i'm thinking it's something related to the ISPconfig configuration.
On friday it started with client A. Went over there, rebooted the modem and it works again for 15mins, rebooted the modem again, and works again for 15mins.
On saturday, Client A worked fine again, didn't change anything @ their configuration.
On sunday, Client B couldn't retrieve e-mail with the same errors as client A on friday. Client A worked fine on sunday.
Tried different solution angles posted on this forum, altering postfix config, trying to connect the clients with secure connections, nothing helped.
Set the Bastille firewall to max logging of failed attempts, when the client that get's errors tries to connect, it doesn't show anything.
Telnetting to port 110 works fine, but not for my clients that get the error messages. They can't connect at all.
Surfing to their domain works fine, so tried surfing to the webmail ( scuirrelmail ). Logging in trough webmail works fine, and the clients can see their e-mail.
As you get the errors when retrieving mail, its not a postfix problem. Postfix is only for sending emails. Wjich error messages do you get in the mail.log for the connection attempts of these clients? Do you use maildir or mbox format for storing the mailboxes?
The strange thing is, the connection attempts of those clients don't even show up in the /var/log/mail log file. If i try it from my home, it shows up fine.
Since this morning, client A and client B both can't connect.
If i try to telnet to port 110, i just get a blinking cursor, not the hello line.
If i try it from my own PC at home, both mail receiving and telnet work fine.
I disabled the Bastille firewall, but that doens't help either.
If i try to ping or nslookup to the mailserver mail.rackserver.be, i get a reply with the ip-adress, so it shouldn't be DNS either.
Then I guess its a problem with a firewall at these clients. Maybe both use the same local firewall and e.g. a automatic update on this software causes the problem. If you are able to connect from other locations to your server, then its most likely not a server problem. Or do you use a software like fdenyhosts that blocks specific IP addresses on your server? The ISPConfig Bastille firewall is not capable of blocking single IP addresses.
I do not use fdeny host.
As far as i can see, the client is connecting to the server, but packets don't get delivered ?
Also some strange packets from pop3 in there ?
When i try to connect trough IMAP (openend port first), then the clients receive the e-mail correctly.
I tried altering the courier configuration, and changed the concurrent connections from 1 ip from 4 to 20, restarted courier-pop and it seems to do the trick for know.
Tried altering the configuration again, changed it back from 20 to 4, and it still works.
Altough it works for know, i think someting is wrong with courier + i find the captured files from the server regarding the pop messages very strange. Hope someone knows what they are.
Had to restart courier-pop to get it working again.
Could it have something to do with the max connections from 1 ip ?
Is it possible to verify the courier-pop connections of 1 ip ?
Changed the max connection from 30 to 100, this should be way sufficient.
Very strange, since postfix is set to only allow outgoing mail from the local network/domains.
Is it possible to display a smtp list of outgoing mails that are in que ?
Please check on your mail log file how many connections you have from this IP. Maybe someone is trying to crack a pop3 account with a brute force attack.
Already checked the connections manually in the mail logs.
The client connects every minute with all account, max 6.
So this would mean a maximum of 6 connections a minute ( 12 if you count login/logout).
This is why i changed the "max connections value"/ip first to 30, and know to 100.
Will try to check the postfix/anvil function this evening.


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Find out about the story of Hamlet
Young Hamlet returns home from university to discover the world-shattering news that, not only is his father (Old Hamlet) newly dead, but that his mother, Gertrude, has married Old Hamlet's brother, Claudius, and that Claudius is now king.The resultant instability has also led to threats of invasion by a solider from a neighbouring state, Fortinbras.
GHOSTLY ENCOUNTER
Late one night, the ghost of Hamlet's father appears to him, accusing Claudius of his murder and urging Hamlet to revenge. This sets in motion a train of events that destroys both family and state.
No longer able to trust his own senses, the loyalty of his old friends, Rosencrantz and Guildernstern, or even the affections of his young love, Ophelia, Hamlet fakes madness in an attempt to provide himself with proof that the ghost is telling the truth. Aided only by his most loyal companion, Horatio, he persuades a travelling band of actors to re-enact the story of his father's murder in front of Claudius and Gertrude, hoping that Claudius will be so stirred by remorse that he will confess his crime.
During an intense meeting with his mother, Hamlet hears a noise and realises that they are being spied upon. In rage, he stabs the hidden eavesdropper, believing it to be Claudius. Instead his discovers it is the King's adviser, Polonius, father to both Ophelia and her brother, Laertes. Polonius dies.
Afraid of what Hamlet might do next, Claudius has him arrested and despatched to England under guard, where he has arranged to have Hamlet murdered. Hamlet escapes, returns to his homeland and finally achieves his revenge.
The psychological effects of these upheavals on Hamlet lead to some of the greatest soliloquies in the English language and take the audience deep into the mind of Shakespeare's most famous protagonist.
Stop reading now if you don't want to know how it ends...
Ophelia, having been violently rejected by Hamlet, hears that her father has been murdered. She loses her mind and eventually drowns herself. Her brother, Laertes, returns to court at the head of an angry mob, determined to find out the truth. Claudius convinces him that Hamlet is the only guilty party and agrees to help Laertes gain revenge.
On learning of Hamlet's escape and return to his homeland, Claudius convinces Laertes to challenge Hamlet to a fencing match and advises Laertes on how to kill Hamlet during the duel without arousing suspicion. As a back-up plan, Claudius also poisons a glass of wine which he intends to offer to Hamlet. Gertrude, however, drinks from the glass first and dies.
During the duel, Hamlet is slightly wounded by Laertes, who has tipped his sword with a deadly poison. In the ensuing tussle, the swords get switched and Hamlet wounds Laertes with the poisoned one. Realising that he is about to die, and that Claudius has manipulated the situation, Laertes confesses everything, forgives Hamlet and dies.
As the poison takes hold and he realises that he too is about to die, Hamlet finally carries through his dead father's wish for revenge. He forces Claudius to drink the remaining poisoned wine, which quickly takes effect.
With his dying breath, Hamlet asks Horatio to ensure that his story is told accurately.
Young Fortinbras arrives at the head of his army, ready to assume control of a state whose royal family has been destroyed by betrayal, murder and revenge.
Studying Hamlet? Then you'll love our new SHAKESPEARE LEARNING ZONE!
Discover loads of facts, videos and in-depth information about Hamlet.
Really get to grips with the stories, settings and characters of Shakespeare's play. Unlock his language using the same techniques our actors use in rehearsals.
Find out about one of Shakespeare's most famous tragedies, Hamlet.
Explore information and resources for teachers and learners on Hamlet
Insights into some of our key past productions, how they were staged and the directorial choices that were made
Hamlet on the Shakespeare Learning Zone
Studying Hamlet? Visit the SHAKESPEARE LEARNING ZONE to discover loads of facts, videos and info about the play


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The Maven orbiter
MAVEN stands for NASA's Mars Atmosphere and Volatile EvolutioN mission. It was launched in November 18, 2013 to examine Mars's upper atmosphere, ionosphere and interactions with the sun and solar wind. [1] [2] MAVEN was placed into orbit on September 21, 2014; in its highly elliptical orbit it travels out to 3,900 miles (6,200 km) then comes in as close as 93 miles (150 km). Each orbit of the planet takes 4.5 hours. With such a large elliptical orbit it can study different parts of the Martian atmosphere.[3]
1 Spacecraft
2 Instruments
3 Findings
4 Additional Duties
7 Recommended reading
MAVEN is 37.5 feet (11.4 meters) long and has a mass of 1991 pounds max (903 kilograms) when empty and a mass of 5622 pounds max (2550 kilograms) at launch. Its solar cells provide 1135 watts of power at Mars when Mars is furthest from the Sun.[4]
Technicians working on solar panels
Neutral Gas and Ion Mass Spectrometer
Langmuir Probe and Waves
Imaging Ultraviolet Spectrometer
Solar Wind Electron Analyzer
Solar Wind Ion Analyzer
Solar Energetic Particles
SupraThermal And Thermal Ion Composition[5]
Of major significance was that MAVEN discovered how Mars lost most of its atmosphere into space. "We've determined that most of the gas ever present in the Mars atmosphere has been lost to space," said Bruce Jakosky, lead author of a paper published in Science. [6] His team's study was based upon two different isotopes of argon gas.[7] [8] Argon gas is inert, it does not react with anything; hence, it is a good marker of how the atmosphere changed. The heavy form of argon is not lost to space as easily as the lighter variety. A larger proportion of heavy isotope on the planet means that more of the gas has disappeared. The ratio of the heavier Ar38 to the lighter Ar36, means that 65% of argon has left the planet. The main way that argon left the atmosphere was through a process called "sputtering." Sputtering is a complex method in which the sun strips atmosphere from a planet. The sun is constantly shooting out particles at high speed. If one hits a gas particle in the atmosphere, it may directly knock it into space. Alternatively, it would cause an atom of atmosphere to lose an electron and thereby become an ion. Ions can interact with the sun's magnetic field as it moves through space. The sun's magnetic field can then sweep them away. In addition ions may hit other atoms in the atmosphere, knocking them into space, as well.[9] This finding that Mars has lost a great deal of its atmosphere, especially water is consistent with several other studies .[10] [11] [12] [13] [14] [15] [16] Although Mars is cold and dry today, it may have been warmer with a thicker atmosphere and liquid water in the distant past. Observations over many years from orbiting satellites have seen what looks like streams, rivers, and lakes on the surface. [17] [18] [19] [20] [21] [22] [23] [24] [25] There is even evidence for an ocean in the past. [26] [27] [28] [29] MAVEN and other missions are showing how Mars could have lost most of its atmosphere.
Artist's conception of MAVEN orbiting Mars
Artist's conception of how the solar wind strikes Mars. On Earth, the solar wind does not reach the Earth's surface because of the Earth's magnetic field.
Drawing showing how Mars lost argon and other gases into space
In September 2017, MAVEN observed an aurora 25 times brighter than any observed earlier, due to a massive, and unexpected, Coronal mass ejection (solar storm).[30]
Aurora before and during a solar event
Additional Duties
Besides studying the atmosphere with a variety of instruments from close and far distances, MAVEN greatly helps with the study of Mars by serving as a relay station between spacecraft on the Martian surface and NASA scientists on the Earth. A probe on the surface would need to wait many hours to send back information when the planet is turned away from the Earth. Much time is saved by using orbiting satellites to pick up and send data from the surface to Earth.
MAVEN with its high-gain antenna in clean room
Just by chance immediately after MAVEN went into orbit, comet C/2013 A1 Siding Spring on October 19, 2014 went by Mars.[31] It took an ultraviolet image of the hydrogen around the comet. The cloud of hydrogen gas was about the same size as our moon as viewed from the Earth.[32] As the comet came close, it was studied with MAVEN's magnetometer (MAG), the Langmuir Probe and Waves (LPW) instrument, and the Solar Energetic Particles (SEP).[33]
↑ https://www.nasa.gov/mission_pages/maven/overview/index.html
↑ https://mars.nasa.gov/maven/
↑ https://en.wikipedia.org/wiki/MAVEN
↑ https://www.nasa.gov/sites/default/files/files/MAVENFactSheet_Final20130610.pdf
↑ https://www.nasa.gov/press-release/nasas-maven-reveals-most-of-mars-atmosphere-was-lost-to-space
↑ B.M. Jakosky et al. 2017. Mars' atmospheric history derived from upper-atmosphere measurements of 38Ar/36Ar. Science 355 (6332): 1408-1410; doi: 10.1126/science.aai7721
↑ http://www.sci-news.com/space/maven-martian-atmosphere-lost-space-04750.html
↑ cite journal | last1 = Krasnopolsky | first1 = Vladimir A. | last2 = Feldman | first2 = Paul D. | year = 2001 | title = Detection of Molecular Hydrogen in the Atmosphere of Mars | url = | journal = Science | volume = 294 | issue = 5548| pages = 1914–1917 | doi=10.1126/science.1065569 | pmid=11729314| bibcode = 2001Sci...294.1914K
↑ Villanueva G. L., Mumma M. J., Novak R. E., Käufl H. U., Hartogh P., Encrenaz T., Tokunaga A., Khayat A., and Smith M. D., Science, Published online 5 March 2015 [DOI:10.1126/science.aaa3630]
↑ Villanueva, G., et al. 2015. Strong water isotopic anomalies in the martian atmosphere: Probing current and ancient reservoirs. Science 10 Apr 2015:Vol. 348, Issue 6231, pp. 218-221.
↑ cite journal | last1 = Webster | first1 = C.R. | display-authors = 1 | last2 = et al | year = 2013 | title = Isotope Ratios of H, C, and O in CO2 and H2O of the Martian Atmosphere | url = | journal = Science | volume = 341 | issue = 6| pages = 260–263
↑ https://www.sciencenews.org/article/mars-dust-storms-water?mode=topic&context=36
↑ N. Heavens et al. Hydrogen escape from Mars enhanced by deep convection in dust storms. Nature Astronomy. Published online January 22, 2018. doi: 10.1038/s41550-017-0353-4.
↑ https://www.jpl.nasa.gov/news/news.php?release=2018-012&rn=news.xml&rst=7041
↑ Baker, V. 1982. The Channels of Mars. Univ. of Tex. Press, Austin, TX
↑ Baker, V., R. Strom, R., V. Gulick, J. Kargel, G. Komatsu, V. Kale. 1991. Ancient oceans, ice sheets and the hydrological cycle on Mars. Nature 352, 589–594.
↑ Carr, M. 1979. Formation of Martian flood features by release of water from confined aquifers. J. Geophys. Res. 84, 2995–300.
↑ Komar, P. 1979. Comparisons of the hydraulics of water flows in Martian outflow channels with flows of similar scale on Earth. Icarus 37, 156–181.
↑ Baker, V.R. (1982). The Channels of Mars. Austin: Texas University Press.
↑ Carr, M. (1979). "Formation of Martian flood features by release of water from confined aquifers". J. Geophys. Res., 84, 2995-3007.
↑ Clifford, S. M.; Parker, T. J. (2001). "The Evolution of the Martian Hydrosphere: Implications for the Fate of a Primordial Ocean and the Current State of the Northern Plains". Icarus. 154 (1): 40–79. Bibcode:2001Icar..154...40C. doi:10.1006/icar.2001.6671
↑ Andrews-Hanna, J., R. Phillips. 2007. Hydrological modeling of outflow channels and chaos regions on Mars. Journal of Geophysical Research: Planets Volume 112, Issue E8
↑ Clifford, S. 1993. A model for the hydrologic and climatic behavior of water on Mars. JGR, 98, 10973L
↑ https://www.sciencedaily.com/releases/2010/06/100613181245.htm
↑ Gaetano Di Achille, Brian M. Hynek. Ancient ocean on Mars supported by global distribution of deltas and valleys. Nature, 2010; DOI: 10.1038/ngeo891
↑ http://astrobiology.com/2016/05/ancient-tsunami-evidence-on-mars-reveals-life-potential.html
↑ Rodriguez, J.; et al. 2016. "Tsunami waves extensively resurfaced the shorelines of an early Martian ocean. :" (PDF). Scientific Reports / 47th Lunar and Planetary Science Conference. 6: 25106. Bibcode:2016NatSR...625106R. doi:10.1038/srep25106. PMC 4872529 Freely accessible. PMID 27196957.version at Nature
↑ last=Scott |first=Jim |title=Large solar storm sparks global aurora and doubles radiation levels on the martian surface |url=https://phys.org/news/2017-09-large-solar-storm-global-aurora.html |date=September 30, 2017
↑ https://spaceflightnow.com/mars/maven/140921moi/
↑ https://mars.jpl.nasa.gov/resources/6689/maven-ultraviolet-image-of-comet-siding-springs-hydrogen-coma/
↑ https://agupubs.onlinelibrary.wiley.com/doi/10.1002/2015GL066300
Oceans on Mars
Rivers on Mars
Initial results from the MAVEN mission to Mars
A comet engulfs Mars: MAVEN observations of comet Siding Spring's influence on the Martian magnetosphere
NASA | Mars Atmosphere Loss: Sputtering
MAVEN | Measuring Mars' Atmospheric Loss
MAVEN's Journey to Mars
MAVEN to Explore Upper Atmosphere of Mars
MAVEN Mission Briefing: Solar Wind Strips Martian Atmosphere
Retrieved from "https://marspedia.org/index.php?title=MAVEN&oldid=128702"
Orbital Missions


text:
"Be anything you want kid ~ but NOT a hairdresser"
Why PRIDE still matters 50 Years later.
This month marks the 50th anniversary of the Stonewall Uprising, widely regarded around the world as a seminal event in the gay rights movement. LGBTQ Pride was not born out of a need to celebrate our being gay, but our right to exist without persecution. Not that long ago, women and men were regularly fired or not hired because of their sexuality. For myself and so many others, Stonewall changed the trajectory of our personal and professional futures, and that of my industry.
The 1969 picture of me shows a precocious, expressive boy excited for the future. My parents saw something else in me that was only ever spoken of in code. I could be anything, but NOT a hairdresser. This was code, of course, for queer. While I didn't pursue a hairdressing career (an honorable profession), I've been fortunate to be a part of a thriving communications industry with a unique capability to influence and inspire profound social change. My life depended on it.
Unlike many of my peers, I was fortunate to find a career with colleagues and clients who accepted and embraced me. I had a great boss in the 1990s who later told me that her supervisor had questioned her judgement for hiring me because she already had "one of those" in her department. "So?" was her brave reply. Thanks to her and others, I was able to thrive, eventually becoming the head of a multinational healthcare communications firm.
Our voices give us power. As agency leader, I have an opportunity – and an obligation – to be proudly and visibly out in the workplace. #UnlimitedPride.
"Aren't you worried you'll get fired?"
When I grew up gay men were called "fags" and "poofters" in polite company. We learned in our churches that we were sinners damned to hell. We were denied civil rights and told that we would never have a family. We carefully cultivated disguises to hide our true selves in closets of lies.
I came out in the 1980s, at the height of the AIDS epidemic. The #LGBTQ community that I became a part of changed the course of a global public health crisis and saved countless millions of lives. While finishing college and preparing for a career, gay men like me were dying by the tens of thousands as our governments and society largely stood by. The stigma of the epidemic amplified long-standing discrimination and homophobia, including in the workplace.
Increasingly, our clients, companies and leaders understand that people are our most important asset. But we have a long way to go before every LGBTQ person feels supported by their employer. The collective sum of our individual differences, life experiences, knowledge, inventiveness, innovation, self-expression, unique capabilities and talent translate directly to a company's reputation and business success. Employers that foster an inclusive, supportive workforce get the best from everyone.
As a leader, I work to ensure a welcoming environment by sponsoring our participation in #WorldPride events, building #diversity and #inclusion into our core values and championing a diverse workforce, #GenderEquality and working with clients advancing progress.
"I don't hate gay people. I just don't know any."
One of my life regrets is that my brother found out I was gay from CNN, instead of hearing it from me first. The 1980s was a scary time for me and the millions of other gay men around the world – our friends were dying of AIDS with no treatments, no cures and no hope of a future. I was not an activist, but I was there at the marches and vigils pleading for help to stop the virus that was killing us.
Watching CNN on October 11th 1987, my brother was surprised to see me waving a pink triangle flag in front of the White House, alongside 500,000 other LGBTQ people and our allies who had marched on Washington that day. (President Reagan was not home; he had not yet acknowledged the AIDS crisis killing tens of thousands of Americans, primarily gay men.). The national march was prompted by two major events in the 1980s: the AIDS pandemic, the Ronald Reagan administration's lack of acknowledgment of the AIDS crisis; and the Supreme Court of the United States ruling upholding the criminalization of sodomy between two consenting men in the privacy of a home. Its success, size, scope, and historical importance have led to it being called, "The Great March."
An awkward telephone call followed, and I learned an important lesson about the cost of hiding our true selves from those who love us. My brother was upset not because I was gay (he had his suspicions), but because I'd been hiding such an important part of me from him – and he was the last to know. I've not hidden who I am or who I love from anyone since.
Visibility is incredibly important and meaningful. My parents always said that what helped them the most to accept my coming out as gay was meeting my friends. Their only frame of reference for gay people were hairdressers and a local nurse who was ridiculed for being effeminate (but sounded so fabulous to me). Meeting my friends helped them understand that I was part of a rich, loving and diverse community.
Since its very beginnings, the fight for equality has belonged to brave, marginalized people whose fierce commitment compels them to protest, march, volunteer, vote and donate. When we speak up about LGBTQ equality, we are creating change. This is particularly important in the workplace, where visible and vocal LGBTQ role models and allies in leadership positions can help ensure a welcoming environment and champion a diverse workforce.
While our clients may be way ahead of us advancing diversity and inclusion, as a society we have a long way to go before every LGBTQ person feels supported by their employer. Many LGBTQ staff, and trans people in particular, still face discrimination, exclusion, barriers and even bullying at work. In the U.K., 35% of LGBTQ employees are still in the closet, and this number goes up to 46% in the U.S. Data shows that many people don't feel comfortable enough to disclose their identity at work, and those who do are often subject to varying degrees of discrimination.
"I'm straight. Where is my pride parade?"
Our right to exist without persecution is not yet secure, so we must raise our voices as individuals, allies, and companies at #PrideMonth events, marches and rallies around the world. Our lives depend on it.
We participate in Pride to demonstrate our commitment to fight for social justice and support the lives of LGBTQ and gender non-conforming people.
We participate in Pride because the history of violence and criminalization of LGBTQ people continues to this day. There is still no U.S. federal law prohibiting discrimination based on sexual orientation or gender identity. Trans women, particularly women of color, continue to be victims of violence at alarming rates.
We participate in Pride because HIV/AIDS continues to be a major public health crisis around the world. #Stigma and #discrimination remain a reality for many people living with or at risk for HIV.
We participate in Pride because we can't do it alone. These celebrations show LGBTQ people around the world that we are accepted and championed by so many.
Together, we have come so far. But there's much more to be done.
Stonewall began shortly after midnight on June 28, 1969, when police officers raided a gay bar, the Stonewall Inn in New York City and started hauling out the patrons. A small group of gay, lesbian and transgender people fed up with longstanding discrimination and harassment at the hands of law enforcement shoved back; threw bricks, bottles, punches. Their protest lasted six days and sparked a movement that is still building today.
I recently visited the Stonewall Inn, now a National Monument, and reflected on how those events changed my life: from the little boy who couldn't be a hairdresser to the out-and-proud global executive that I am today. The greatest lesson I've learned along the way is the need to repay that debt forward by being a visible role model, building an inclusive workplace, and fostering the careers of diverse and talented communicators.#MeaningfulChange
Our industry's capability to influence matters. Pride still matters. Being out and proud, at home and in the office, will always matter.
About The Author: Timothy Bird is global CEO of Health Unlimited, a global health consultancy and communications agency with regional hubs in New York City and London. A part of the Unlimited Group.


Mahjongg Solitaire (also known as Shanghai) is a very gripping, but also relaxative game. The aim is to remove as much pieces as possible. However, only equal pairs can be removed. Moreover, only pieces which are "free" can be chosen, i. e. there mustn't be a piece neither on the left or the right side, nor above. This very successful version contains a 3-D viewing mode, diverse piece designs and 25 (!) different placing systems which can be changed and stored comfortably by using the integrated level editor.