Mintz represents one of the world's leading media and entertainment companies in its acquisition of a site in Needham, Massachusetts for its new broadcast studio, media, and office location in the Boston market.
The media and entertainment company acquired a former industrial site, now a separate condominium unit in a master development, which the company will redevelop. Mintz's representation included advice and counsel on purchase and sale, title, condominium, land use, and restriction issues. We also assisted with a construction management agreement with the master developer.
Our client, the media and entertainment company, completed the acquisition. This will allow the company to create a new regional headquarters and broadcast location in a convenient, high-visibility location.


text:
Woman dies in Lagos church during childbirth, prophetess arrested
FSuspects in house help's murder
By Deji Lambo
Four nabbed over domestic worker's death
Deji Lambo
A prophetess, Evelyn Owoleke, has been arrested in connection with the death of one Seun Olorunto during childbirth at the Cherubim and Seraphim Church, Bayo Ajao Street, in the Aboru area of Lagos State.
PUNCH Metro gathered that Olorunto was to be delivered of her baby in the church but allegedly bled to death.
The state Police Public Relations Officer, Bala Elkana, said in a statement on Sunday that Olorunto was found in a pool of her own blood when detectives visited the church, adding that the corpse had been deposited in a mortuary and the baby taken to hospital.
Elkana stated, "On May 4, 2020, around 7.50pm, one Olaloye Jolayemi of Ologundudu Street, Aboru, reported at the Oke-Odo Police Station that on May 4, 2020, around 10am, one Seun Olorunto, 39, died after she was delivered of a baby boy by one Prophetess Evelyn Owoleke at the Cherubim and Seraphim Church on Bayo Ajao Street, Aboru.
"Homicide detectives visited the scene and found the woman lying in a pool of her own blood, suggesting that she might have bled to death due to complications. The corpse was removed from the church to the General Hospital, Yaba, for autopsy.
"The infant was taken to hospital for medical examination and care. The traditional/spiritual midwife was arrested and taken to the SCIID, Yaba. An investigation is ongoing."
In another development, men of the command have arrested four suspects in connection with the death of a domestic worker, Halimat Sodiq, in the Bariga area of the state.
PUNCH Metro gathered that Halimat's boss, Shade Moke, had accused her of stealing N2,000 and reportedly invited three men to torture her in a bid to extract confession from her.
Elkana said Halimat died in the process, adding that the suspects secretly buried her at the Atan Cemetery to conceal the crime.
READ ALSO: Man in custody for raping fried potato seller
He stated that the suspects denied the crime when interrogated, adding that the case had been transferred to the State Criminal Investigation and Intelligence Department, Panti, Yaba, for further investigation.
"On Saturday, May 9, 2020, around 11.30am, the Bariga Police Station received information that one Shade Moke, 41, conspired with three others on February 29, 2020, and killed one Halimat Sodiq, 16, over an allegation of stealing.
"The victim was said to be a house help to Shade Moke. She was accused of stealing N2,000 from her madam, which she denied. The madam invited the other three suspects, who tortured the girl to death. "They buried her secretly at the Atan Cemetery in order to conceal the murder."
Similarly, policemen attached to the Mushin Police Station have arrested one Owolabi Fasasi for alleged involvement in the death of one Taiwo Adekoya in the Mushin area of the state.
Elkana said Fasasi was attempting to dispossess Kausarat Owolabi of her three-month-old baby when he pushed Adekoya, who was pacifying him, to the ground.
He stated that Adekoya became unconscious and was taken to hospital, where she was confirmed dead, adding that Fasasi would be charged.
Meanwhile, the police have arrested 16 persons for allegedly terrorising residents of Itire and Ikorodu areas of the state.
Elkana identified the suspects arrested in Itire as Ahmed Ajibosi, Quam Gabriel, Rasheed Afolabi, Terry Ebode, Ibe Ugochukwu, Yusuf Abubakar, Uche Ndubuisi, Lateef Akintunde, Ojo Sunday and Wale Sodiq.
Those arrested in Ikorodu are Olushola Shotola, 33; Samuel Adebayo, 28; Umaru Ibrahim, 23; Ayo Idowu, 30; Gbolahan Adeola, 18; and Hammed Lukman, 35.
He stated that an investigation was ongoing into their respective cases, adding that the suspects would be charged.
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The PPRO also stated that the command had commenced investigation to determine the whereabouts of 15-year-old Daniel Michael, who suddenly disappeared from an orphanage in the Ikotun area of the state.
He said the Administrative Officer, Finger of God Orphanage Home, Ernest Madu, reported the case, adding that efforts to find Michael were ongoing.

redpajama_set_name: RedPajamaCommonCrawl


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Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance
Brandyn D. Henriksbo1,
Trevor C. Lau1,
Joseph F. Cavallari1,
Emmanuel Denou1,
Wendy Chi1,
James S. Lally2,
Justin D. Crane2,
Brittany M. Duggan1,
Kevin P. Foley1,
Morgan D. Fullerton1,2,
Mark A. Tarnopolsky2,3,
Gregory R. Steinberg1,2 and
Jonathan D. Schertzer1,3⇑
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
2Department of Medicine, McMaster University, Hamilton, Ontario, Canada
3Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
Corresponding author: Jonathan D. Schertzer, schertze{at}mcmaster.ca.
Diabetes 2014 Nov; 63(11): 3742-3747. https://doi.org/10.2337/db13-1398
Statins reduce lipid levels and are widely prescribed. Statins have been associated with an increased incidence of type 2 diabetes, but the mechanisms are unclear. Activation of the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1 inflammasome, promotes insulin resistance, a precursor of type 2 diabetes. We showed that four different statins increased interleukin-1β (IL-1β) secretion from macrophages, which is characteristic of NLRP3 inflammasome activation. This effect was dose dependent, absent in NLRP3−/− mice, and prevented by caspase-1 inhibition or the diabetes drug glyburide. Long-term fluvastatin treatment of obese mice impaired insulin-stimulated glucose uptake in adipose tissue. Fluvastatin-induced activation of the NLRP3/caspase-1 pathway was required for the development of insulin resistance in adipose tissue explants, an effect also prevented by glyburide. Fluvastatin impaired insulin signaling in lipopolysaccharide-primed 3T3-L1 adipocytes, an effect associated with increased caspase-1 activity, but not IL-1β secretion. Our results define an NLRP3/caspase-1–mediated mechanism of statin-induced insulin resistance in adipose tissue and adipocytes, which may be a contributing factor to statin-induced development of type 2 diabetes. These results warrant scrutiny of insulin sensitivity during statin use and suggest that combination therapies with glyburide, or other inhibitors of the NLRP3 inflammasome, may be effective in preventing the adverse effects of statins.
Therapy with statins inhibits hydroxymethylglutaryl-CoA reductase, a rate-limiting enzyme in cholesterol biosynthesis, and reduce LDL cholesterol levels. Statins have actions beyond lipid-lowering effects, which include modulation of immune function (1). Statins decrease intermediates in the mevalonate pathway that lie upstream of cholesterol formation, reducing protein prenylation, a post-translational lipid modification that occurs on many proteins, including those involved in immune responses (1). Immune proteins such as pattern recognition receptors (PRRs) have emerged as integrators of nutrient- and pathogen-sensing systems, and the inflammation that occurs during obesity (i.e., metaflammation) has been characterized in terms of excess nutrients and energy (2). Drug-mediated changes in inflammation via engagement of PRRs should also be considered, particularly for therapeutic agents such as statins that are used to treat aspects of metabolic disease.
Statin-mediated decreases in protein prenylation are generally associated with anti-inflammatory responses and can reduce levels of tumor necrosis factor and interleukin (IL)-6 in lipopolysaccharide (LPS)-treated peripheral blood (3). In contrast, statins have been associated with increased secretion of the proinflammatory cytokine IL-1β; an effect that requires caspase-1 activity and priming with another immunogenic agent such as LPS (4). These features are indicative of regulation by the inflammasome containing the PRR, NOD-like receptor family, pyrin domain containing 3 (NLRP3; also referred to as NACHT, leucine-rich repeat, and pyrin domains-containing protein 3 or cryopyrin) (5,6). The NLRP3 inflammasome is causally linked to the development of insulin resistance in rodents (7) and has recently been shown to be activated in macrophages of patients with newly diagnosed insulin-resistant type 2 diabetes (8). Statin therapy has been associated with increased incidence of type 2 diabetes, as high as 48% in certain populations (9,10). Glyburide, a drug that is widely prescribed for the treatment of diabetes, inhibits the NLRP3 inflammasome independently of cyclohexylurea-mediated insulin secretion (11). We hypothesized that statin-mediated activation of the NLRP3 inflammasome promotes insulin resistance, which could be attenuated by glyburide.
Mice and Materials
The McMaster University Animal Ethics Review Board approved all procedures. Male wild-type (WT) C57BL/6 (catalog #000664) and leptin-deficient ob/ob (catalog #000632) JAX mice were from The Jackson Laboratory. NLRP3−/− mice (>10 generations backcrossed to C57BL/6) were from Professor Nicolas Fasel (Université de Lausanne, Lausanne, Switzerland) and were provided by Dr. Dana Philpott (University of Toronto, Toronto, ON, Canada). To determine the effect of long-term statin treatment on insulin-stimulated tissue glucose uptake, ob/ob mice were orally administered 40–50 mg/kg fluvastatin or vehicle 5 days a week for 6 weeks, a dose of fluvastatin that has been used in other mouse models (12). Twenty-four hours after the last dose, mice were injected with 2 μCi of 3H-2-deoxy-d-glucose (2DG) via tail vein, immediately followed by the administration of insulin (4 units/kg i.p.). Blood samples were taken at baseline, 5, 10, 15, and 20 min, and were analyzed for 2DG radioactivity. Mice were killed by cervical dislocation, and tissues were snap frozen in liquid nitrogen. Brown adipose tissue (BAT) and gonadal white adipose tissue (WAT) were analyzed for 2DG radioactivity with and without deproteinization (0.3 mol/L BaOH and 0.3 mol/L ZnSO4) to calculate the rates of tissue-specific glucose uptake. Statins were from Cayman Chemical (Ann Arbor, MI). InvivoGen (San Diego, CA) supplied ultra-pure LPS (Escherichia coli 0111:B4). z-WHED-FMK and caspase-1/3 kits were from R&D Systems (Denver, CO). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) kit and all other chemicals were from Sigma-Aldrich (St. Louis, MO).
Macrophages
Bone marrow–derived macrophages (BMDMs) were cultured for 7–10 days in DMEM containing 10% FBS and 15% L929 conditioned media. BMDMs were washed in serum-free media and exposed to statin (1 μmol/L fluvastatin, unless otherwise stated) for 18 h in serum-free DMEM and LPS (200 ng/mL) was added during the final 4 h. GGPP (10 μmol/L), z-WHED-FMK (10 μmol/L), and glyburide (200 μmol/L) were used during the statin treatment period. IL-1β and IL-6 were quantified by ELISA. Transcript levels were analyzed by quantitative PCR, as described previously (13,14).
Adipose Explants and Adipocytes
Mice were killed by cervical dislocation, and PBS-rinsed gonadal adipose tissue was minced into ∼5-mg pieces in DMEM containing 10% FBS. After 2 h of equilibration, 25 mg explants were placed in serum-free DMEM and exposed to 10 μmol/L fluvastatin (18 h) and 2 μg/mL LPS (4 h), and were stimulated with 0.3 nmol/L insulin for 10 min. Adipose tissue lysates were used for determination of caspase-1/3 activity (over 4 h), immunoblotting, or ELISA determination of cytokines, as described previously (14). 3T3-L1 preadipocytes (ATCC, Rockville, MD) were differentiated (14), and fluvastatin/LPS treatment was similar to explants. 3T3-L1 media were used for ELISAs, and lysates were used to measure caspase-1 enzymatic activity fluorometrically or for immunoblotting after insulin stimulation at 0.3 or 100 nmol/L for 10 min.
Significance was determined by unpaired, two-tailed t tests or ANOVA, as appropriate. A Bonferroni or Tukey post hoc test was used when appropriate (Prism 4–6; GraphPad Software).
Statins Activate the NLRP3 Inflammasome
All statins (10 μmol/L, 18 h) increased the secretion of IL-1β from WT BMDMs compared with LPS alone (Fig. 1A). Fluvastatin increased IL-1β secretion in a dose-dependent manner only with LPS priming (Fig. 1B), but LPS alone increased IL-6 secretion in BMDMs (Fig. 1C). Fluvastatin up to 100 μmol/L did not lower BMDM viability detected using the MTT assay (data not shown). The isoprenyl intermediate GGPP prevented fluvastatin-induced IL-1β secretion in LPS-primed BMDMs (Fig. 1D), suggesting that decreased prenylation drives statin-mediated inflammasome activation. Inhibition with z-WHED or glyburide prevented statin-induced IL-1β secretion in LPS-primed BMDMs (Fig. 1E). LPS treatment, but not fluvastatin treatment alone, increased transcript levels of NLRP3, IL-1β, and IL-6 (Fig. 1F and G). Therefore, statins alone did not alter inflammasome-priming events such as increased NLRP3 transcript levels (15). The combination of fluvastatin and LPS synergistically increased both IL-1β and IL-6 transcript levels (Fig. 1F). Fluvastatin did not increase IL-1β secretion in LPS-primed BMDMs from NLRP3−/− mice (Fig. 1H). LPS increased IL-6 secretion BMDMs from NLRP3−/− mice (Fig. 1I).
Statins activate the NLRP3 inflammasome in macrophages. A: BMDMs from WT mice were treated with various statins (10 μmol/L, 18 h) and/or LPS (200 ng/mL, 4 h), and IL-1β in the media was quantified. BMDMs were treated with various doses of fluvastatin and/or LPS, and IL-1β (B) and IL-6 (C) in the media were quantified. D: BMDMs were treated with LPS, and 1 μmol/L fluvastatin combined with vehicle or 10 μmol/L GGPP and IL-1β in the media was quantified. E: BMDMs were treated with LPS, and 1 μmol/L fluvastatin combined with vehicle, or 10 μmol/L z-WHED-FMK, or 200 μmol/L glyburide and IL-1β in the media was quantified. Transcript levels of cytokines (F) and PRRs (G) in BMDMs after 1 μmol/L fluvastatin (18 h) and 200 ng/mL LPS (4 h) treatment. BMDMs from NLRP3−/− mice were treated with various doses of fluvastatin and/or 200 ng/mL LPS, and IL-1β (H) and IL-6 (I) in the media were quantified. *Significantly different from LPS alone or as indicated by connecting bars; ϕsignificantly different from conditions without LPS; #significantly different from fluvastatin plus LPS; ^significantly different from control or statin alone. Statin, fluvastatin. Values are shown as the mean ± SEM. n > 3 for all conditions.
Fluvastatin Impairs Adipose Tissue Insulin Signaling Via the NLRP3 Inflammasome
We first established that long-term oral administration of fluvastatin impaired insulin-simulated glucose disposal into adipose tissue using an in vivo mouse model of obesity. 2DG uptake was >50% lower in WAT, but not BAT, of fluvastatin-treated ob/ob mice (Fig. 2A). We then used WAT explants to determine the mechanisms of statin-induced insulin resistance. Fluvastatin increased caspase-1 activity in LPS-primed adipose tissue from WT mice, but not from NLRP3−/− mice (Fig. 2B). Glyburide prevented this increased caspase-1 activity (Fig. 2B). Fluvastatin increased caspase-3 activity in LPS-primed adipose tissue from WT and NLRP3−/− mice and independently of glyburide treatment (Fig. 2C). Therefore, fluvastatin activated an NLRP3-dependent, glyburide-sensitive, caspase-1 inflammasome in adipose tissue.
Fluvastatin activates the NLRP3 inflammasome and impairs insulin signaling in adipose tissue. A: In vivo insulin-stimulated 2DG uptake in BAT and WAT from ob/ob mice orally treated with vehicle (Control) or fluvastatin (Statin) for 6 weeks (n ≥ 3 mice per group). Caspase-1 (B) and caspase-3 (C) activity in adipose tissue explants from WT mice and NLRP3−/− mice, where explants (n > 7) were treated with vehicle (control), LPS (2 μg/mL) plus 10 μmol/L fluvastatin (L+S) or L+S plus 10 μmol/L glyburide (L+S+Glyb). D: Quantification of IL-1β in adipose tissue lysates from WT and NLRP3−/− mice after treatment of explants with vehicle (control), LPS, fluvastatin, or LPS plus fluvastatin. E: Representative immunoblots (left) and quantification (right) of basal (Bas; i.e., no insulin) and insulin-mediated pAkt (serine 473) after treatment with fluvastatin and/or LPS in adipose tissue explants (n > 6) from WT and NLRP3−/− mice. F: Representative immunoblots (left) and quantification (right) of basal and insulin-mediated phosphorylation of Akt after treatment with fluvastatin and LPS with various doses of glyburide in adipose tissue explants from WT mice. ϕSignificantly different from control or basal; εsignificantly different from L+S; ^significantly different from LPS alone in WT; #significantly different from vehicle control (with insulin). Statin, fluvastatin. Values are shown as the mean ± SEM. n ≥ 8 explants per group. AU, arbitrary units.
Surprisingly, LPS alone increased IL-1β in adipose explants from both WT and NLRP3−/− mice (Fig. 2D). Fluvastatin plus LPS further increased IL-1β levels compared with LPS in adipose explants from WT mice, but not NLRP3−/− mice (Fig. 2D). LPS alone did not change the ability of insulin to phosphorylate Akt at serine 473 in adipose tissue explants (Fig. 2E). Fluvastatin alone impaired insulin-mediated phosphorylated Akt (pAkt) in adipose tissue from WT mice, but not NLRP3−/− mice (Fig. 2E). The combination of LPS and fluvastatin prevented the ability of insulin to increase the levels of pAkt in adipose tissue explants from WT mice, but not NLRP3−/− mice (Fig. 2E). Glyburide reversed fluvastatin-induced suppression of insulin-mediated pAkt in LPS-primed adipose explants, but glyburide did not increase pAkt levels on its own (Fig. 2F).
Interestingly, changes in caspase-1 activity, but not Il-1β secretion mirrored statin-induced insulin action in adipose explants. There are many nonadipocyte cell types and potential sources of IL-1β processing in adipose tissue (16), so we next tested the adipocyte cell-autonomous response. Treatment with fluvastatin plus LPS increased caspase-1 activity in 3T3-L1 adipocytes, but did not increase IL-1β or IL-6 secretion (Fig. 3A–D). However, treatment with fluvastatin plus LPS significantly lowered insulin-stimulated pAkt in 3T3-L1 adipocytes (Fig. 3E).
Cell-autonomous actions of fluvastatin in adipocytes. Time course (A) and quantification (B) of relative caspase-1 activity in 3T3-L1 adipocytes after treatment with vehicle (Control) or LPS plus fluvastatin (L+S) (n ≥ 7/group). Quantification of IL-1β (C) and IL-6 (D) secreted in the media after control or L+S (n ≥ 8/group). E: Representative immunoblots (left) and quantification (right) of 0.3 and 100 nmol/L insulin-stimulated phosphorylation of Akt (serine 473) in 3T3-L1 adipocytes after treatment with control or L+S (n = 4/group). *Significantly different from control (no insulin); #significantly different from control at the same dose of insulin. AU, arbitrary units; Con, control; nd, not detected; Statin, fluvastatin. Values are shown as the mean ± SEM.
Treatment with statins lowers blood lipid levels and reduces the number of cardiovascular disease–related events (17). Paradoxically, statins have been associated with an increased incidence of diabetes. This has sparked debate over reassessing the benefits and risks of statin use (18). Understanding how statins promote adverse effects such as the progression to diabetes may promote improvements in this drug class. We show that statins activate the NLRP3 inflammasome in various immune and metabolic cells of adipose tissue. Fluvastatin-induced impairments in insulin signaling were dependent upon the NLRP3 inflammasome. The commonly used diabetes drug glyburide inhibited statin-induced inflammasome activation and prevented defects in adipose tissue insulin action.
Endogenous and exogenous stimuli activate the NLRP3 inflammasome, which prompted the theory that this PRR is a metabolic danger sensor (19). Production of bioactive IL-1β (or IL-18) by the NLRP3 inflammasome requires priming and stimuli-promoting assembly of a caspase-1 protein complex. We confirm that statins increased IL-1β secretion in adequately primed macrophages (5,6,20), and we demonstrated the requirement of the NLRP3 inflammasome. Glyburide, an existing diabetes drug, inhibited statin-induced increases in IL-1β in macrophages, which is consistent with its inhibitory effect on other inflammasome activators (11). All statins tested activated NLRP3-mediated increases in IL-1β, which is similar to the class effect of these hydroxymethylglutaryl-CoA reductase inhibitors increasing the risk of diabetes, independently of potency or lipophilic properties (18). A standard dose of fluvastatin can equate to micromolar serum levels in humans (21), and other statins can reach serum levels >10 μmol/L (22), which corresponds with the effective dose range of our in vitro models. The dose response of fluvastatin-induced IL-1β secretion that we report is consistent with higher doses of statins increasing the risk of diabetes to a greater extent (18). This is important because of the diminishing returns of lipid lowering as the dose of statins is increased, the high dose of statins required to achieve adequate lowering in many patients, and the incidence of statin intolerance in clinical practice (23).
Adipose tissue is a key site of inflammation during insulin resistance, and the NLRP3/caspase-1 inflammasome regulates adipose tissue inflammation and function (24). We first showed that 6 weeks of oral fluvastatin treatment in ob/ob mice impaired insulin-stimulated glucose uptake in WAT, a depot where insulin normally increases glucose disposal from the blood. Statin feeding in these mice had no effect on glucose uptake in BAT, highlighting the specificity of this statin-mediated effect. We then provided genetic evidence that statins impaired adipose tissue insulin action via the NLRP3 inflammasome, which was also prevented with glyburide ex vivo. The combination of LPS and fluvastatin was most effective in preventing insulin-mediated signals in adipose tissue explants. However, fluvastatin did not require LPS to cause impaired insulin action, suggesting that adipose tissue contains endogenous NLRP3 inflammasome-priming signals. This is consistent with the NLRP3 inflammasome mediating obesity-associated insulin resistance in response to saturated lipids (7). Intriguingly, NLRP3 was not necessarily required for IL-1β secretion from adipose tissue explants. Since the regulation of IL-1β did not mirror changes in insulin action, our results suggest that caspase-1 rather than IL-1β provides the link to adipose tissue insulin resistance. Further, a cell-autonomous program that increases caspase-1 activity can be engaged by fluvastatin in LPS-primed clonal adipocytes. This response in 3T3-L1 adipocytes did not increase IL-1β secretion, but impaired insulin action. Therefore, our results suggest that fluvastatin acts through the NLRP3/caspase-1 inflammasome in multiple cells within adipose tissue and culminates in insulin resistance that does not necessarily require Il-1β. Our results concerning insulin resistance have focused on fluvastatin, but the type of statin and pleiotropic actions on inflammation (which are often conflicting) in immune cells, liver, muscle, adipose tissue, and pancreas should be considered in obese and prediabetic mice and patients (25,26). Little is known about the contributing factors to the statin-diabetes relationship. We propose a role for inflammation and that inflammasome-mediated insulin resistance is positioned as a contributor to the development of diabetes. It is enticing to speculate that metabolic endotoxemia or other priming agents for the inflammasome may play a role (27).
We propose that the inhibition of NLRP3/caspase-1 inflammasome may attenuate statin-induced insulin resistance. This is particularly relevant in mitigating any contribution of statins to insulin resistance leading to diabetes in obese hyperlipidemic patients who commonly use this class of drugs for lipid lowering, but are often at risk for the development of diabetes. The next generation of statins may be driven by combination therapy or statin derivatives that maintain or enhance lipid-lowering properties, but allay adverse effects by evading the NLRP3 inflammasome.
Acknowledgments. The authors thank the Université de Lausanne (Lausanne, Switzerland) and the Institute of Arthritis Research for the NLRP3−/− mice.
Funding. This work was supported by grants to J.D.S. from the Canadian Institutes of Health Research (CIHR) (grants PNI123793 and MOP130432), the Canadian Diabetes Association (CDA), Natural Sciences and Engineering Research Council (grant 435474-2013), and a CIHR grant to G.R.S. J.F.C. was supported by a Canada Graduate Scholarship (CIHR). J.D.C. was supported by MAC-Obesity research funds (McMaster University). M.D.F. was supported by Banting and CIHR postdoctoral fellowships. G.R.S. holds a Tier II Canada Research Chair. J.D.S. is supported by a CDA Scholar award.
Duality of Interest. G.R.S. is on the scientific advisory board and received honoraria from Esperion Therapeutics. No other potential conflicts of interest relevant to this article were reported.
Author Contributions. B.D.H. researched the data, contributed to the discussion, and edited the manuscript. T.C.L., J.F.C., E.D., W.C., J.S.L., J.D.C., K.P.F., B.M.D., and M.D.F. researched the data. M.A.T. and G.R.S. contributed to the discussion and edited the manuscript. J.D.S. researched the data, derived the hypothesis, and wrote the manuscript. J.D.S. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
See accompanying article, p. 3569.
Accepted May 31, 2014.
© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
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. NLRP3 inflammasome activation in coronary artery disease: results from prospective and randomized study of treatment with atorvastatin or rosuvastatin. Clin Sci (Lond) 2014;126:233–241pmid:23944632
Cani PD,
Bibiloni R,
Knauf C,
. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008;57:1470–1481pmid:18305141
November 2014, 63(11)
You are going to email the following Fluvastatin Causes NLRP3 Inflammasome-Mediated Adipose Insulin Resistance
Brandyn D. Henriksbo, Trevor C. Lau, Joseph F. Cavallari, Emmanuel Denou, Wendy Chi, James S. Lally, Justin D. Crane, Brittany M. Duggan, Kevin P. Foley, Morgan D. Fullerton, Mark A. Tarnopolsky, Gregory R. Steinberg, Jonathan D. Schertzer
Diabetes Nov 2014, 63 (11) 3742-3747; DOI: 10.2337/db13-1398
Central Regulation of Branched-Chain Amino Acids Is Mediated by AgRP Neurons
Small Amounts of Dietary Medium-Chain Fatty Acids Protect Against Insulin Resistance During Caloric Excess in Humans
Cardiac Autophagy Deficiency Attenuates ANP Production and Disrupts Myocardial-Adipose Cross Talk, Leading to Increased Fat Accumulation and Metabolic Dysfunction
Show more Metabolism


A comprehensive meal plan designed by a registered dietitian, specifically for women, and based on your current activity level and hormonal challenges you may have.
This program is meant to get you quick results. If you have a vacation planned or special event, I encourage you to workout as many days as you can fit into your schedule for these 2 weeks. The additional activity will add up.
As for your meal plan, prepping is key. Keep plenty of low calorie options such as cut up raw veggies and hard boiled eggs on hand. Quick, grab and go snacks will make a world of difference.
Set some goals, decide what you are willing to do to get there and put the work in. Commitment and dedication will guarantee you success.


JB James Construction needed a website redesign to compete in the digital market and a newsletter for improved internal communication. That, coupled with its new 15th anniversary logo, gave way to a cohesive brand identity.
We developed a fresh, interactive website and a convenient, mail-able employee newsletter to revamp internal and external communication. The website theme was threaded through all elements, and the distinctive shape of the 15th anniversary logo reflects the industry and stands out from the traditional.


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The School Programme
School Teachers
Masters Course
Esoteric Tarot Course
Jaye Vickers Dip.CSN.AIN
Connaissance School Teacher
Teacher of the Foundation, Diploma and Tarot Courses at the Connaissance School of Numerology
Jaye has been passionate about numbers since childhood, and had always felt that numbers were not just numbers, but symbols containing hidden messages of energy. Later, in her mid forties, the Foundation and Diploma Course in Numerology at the Connaissance School of Numerology led Jaye on journey of inspiration and self-discovery. This became a turning point in her life and Jaye is now a dedicated teacher of esoteric numerology and tarot at the Nederland Connaissance School of Numerology. Leaving behind a career as first an accordionist and then a clinical hypnotherapist and pyschotherapist, Jaye now dedicates most of her time to teaching Numerology, as she feels that numerology is the most effective tool for personal development and transformation. She firmly believes that when there is complete understanding of the patterns of energy that we are working in the numbers in our birthchart, we can steer through life with more wisdom, compassion and wholeness for ourselves and others.
Jaye is married with three grown up children. Recently she has moved with her husband to Holland, and has now opened the doors of the Nederland Connaissance School of Numerology. The school is in Edam, North Holland, and offers workshops, foundation and diploma courses in esoteric numerology and the esoteric tarot.


text:
Sierra Jones signs with Ausarata Barakaldo E.S.T. in Spain
Former Belmont women's basketball star Sierra Jones has signed with the professional Spanish club Ausarata Barakaldo E.S.T..
"I woke up on June 19 to a message via Facebook with a coach reaching out to me asking if I would like to play in Spain and play for him," Jones said.
Before graduating in May, Jones was one of the core members of Belmont's women's basketball team — which won three straight Ohio Valley Conference tournaments and 46 straight conference games.
In her final season as a Bruin, Jones averaged 5.1 points per game and 4.2 rebounds per game.
"Belmont did everything possible for me," said Jones. "I've learned how to put myself last and others before me on and off the court."
But Jones' time at Belmont was also full of difficulties, including a car accident and a mysterious illness.
"My first three years were rough on and off the court. I got hit with life many times, but I had the right people around me. My relationship with God was strengthened because of it, and I have learned how to handle adversity," Jones said.
Jones majored in Spanish during her time at Belmont, so the language barrier won't be a major difficulty for her as she transitions to living in Spain, but she's still excited about the unexpected parts of moving to a new country, she said.
"I believe that's the best part because I'm not in control, God is!" Jones said. "And as a basketball player, I want to really continue to enjoy playing this game and get better each day and see where that takes me."
Preview: Women's basketball gears up for another outstanding season
Women's basketball wins close battle against Austin Peay, 78-75
WBB, MBB take home 2016 Battle of the Boulevard
Women's basketball defeats UT Martin, advances to championship game


We are running education sessions in schools, sporting clubs AND businesses for FREE to be able to provide a better understanding of mental health, help remove the stigma associated with mental health and mental illness & help implement positive strategies to improve mental health across Australia.
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In order to link the two tables , i need to update the address id field in person table once the address table is updated with all the available addresses ? if yes , that should be done manually ! i have over 3000 records..
could someone suggest a detailed method of how this can be done in a much easier way.
The way things stand now, if you don't have any address ID's filled in the "person" table, you would in fact have to manually figure out which address belongs to which person and enter the appropriate address ID in that person's record. Very time consuming.
If you have a single table somewhere with the person and address combined, the best thing to do would be to assign an address ID to each person in that table however you see fit (it makes the most sense to use something derived from real life, such as customer number or something like that). Then you could split the table into a person and address table, retaining the address ID in each one.
can this be done using triggers in sql ?
My knowledge of SQL is not advanced enough to advise you on the use of triggers. Here's what you can do though.
I personally think the ID structure you are using could be setup a little differently; the way it is now, you will either have a one-to-one relationship between a person and their address, or worse be storing a person more than once in the person table, with a different address ID each time, should you want to store more than one address for a person. By modifying the key structure a bit you can increase the flexibility of the database and maintain a normalized table structure.
Mailing Addresses: Multiple addresses/address history?


She is the unicorn of artists-whimsical, fun and talented! The world would not be quite as bright without her!
Barrie Saltzman I was going to say EXACTLY what everyone else already said….hate when that happens! Seriously….Marti is just an amazing artiste…what more can I say? I have a "sizeable" collection of her artwork, including a custom piece of my own horses in which she captured their personalities perfectly! I recently added a felt scarf and am eyeing up a felt handbag…so don't you dare think about it, you. And YOU know who you are…LOL! Happy, happy, merry, merry horses exuding loads of happiness and positive fun stuff!
Beverly Truddle Richardson When you feel as if your heart will stop beating, and you cannot think to take another breath, Marti will step forward and show you the way to another day.
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Templeton Thompson marti's one of THE MOST talented people I know y'all!:) she's a ROCKSTAR:)! love ya cowgirl, tt & the planet cowgirl herd:)♥.
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Dan Crowley Marti is truely the real deal.
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Norma Jeane Safford Vela Marti is fabulously creative, innovative and energetic. She has a passion for her art, her horses and life! If you have the opportunity to work with Marti, JUMP at it!


Richard Jenkins, John Magaro, Michael Weston and Elizabeth Reaser are all joining the indie love story "Liberal Arts" for Tom Sawyer Entertainment reports Variety.
"HappyThankYouMorePlease" star/director Josh Radnor plays Jesse Fisher, a 35-year-old admissions worker at a Gotham college who visits his liberal arts alma mater in Ohio where a 19-year-old student named Zibby (Elizabeth Olsen) tries to romance him.
Jenkins will play Jesse's favorite college professor who introduces Jesse to Zibby's family, Magaro will play a depressed college student who befriends Jesse, Weston will play one of his NYC friends, and Reaser will play a bookstore employee and potential love interest for Jesse.
Radnor wrote the script while Jesse Hara is producing. Shooting kicks off in June.


www.internetkeywords.org - Internet Garage Door Opener Retrofit. In today's world, Every other internet marketing company is claiming to be the best one. Well, it's obviously not true! with the help of this article, we will try and educate you more on how these internet marketing company's work and how they can make you believe that they are the best even though they are the worst! This really is similar to Internet Garage Door Opener Retrofit.
North Shore Commercial Door has the LiftMaster 893MAX 3 Button Visor Remote Control Garage Door Opener. The opener is able to work with door openers made by LiftMaster, Chamberlain and Sears Craftsman.. We live in a world where we need to be connected all the time. Making sure that you have fast speed internet is extremely important. The question is, what is the best way to get fast speed internet?
Linked to Internet Garage Door Opener Retrofit, After the advent of internet, a lot of things have changed. They had to, because of the power internet had within. Internet has changed the very way we used to lead our lives 30 years ago. It has made our lives easier and the world smaller. It has hit almost all the cultures of the world both negatively and positively.
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CLEMSON – Head women's basketball coach Audra Smith joined Roy Philpott on the flagship station of Clemson Athletics, WCCP 105.5 FM on Wednesday to talk about a bevy of topics, led by the substantial rules changes.
The Tigers open the 2015-16 season in a cozy Jervey Gym atmosphere as Littlejohn Coliseum undergoes a complete transformation (see progress). Smith expressed how excited she is about playing in there, citing the intimate atmosphere and the proximity of the stands to the court. Fans will be right on top of the action in the facility.
While most of the returners have been on campus all summer, the newcomers join the squad in late June to begin classes. Clemson will have seven newcomers, as the roster will be comprised of no seniors, one junior, seven sophomores and seven freshmen.


We having a meeting this coming month since its Catcon year?
Yes, still having a meeting, will be on the 13th, weekend after Catcon.
Thanks Mike. How are your Discus doing?
Discus are doing good. Most of the ones I got from Discus R Us got large and have been healthy, I have another medium sized one from a club member doing well, and I recently got some small homegrown juvies through the Keystone Clash auction. I'm planning to pick up a few more from Hans and eventually combine everyone, but so far I'm happy with the progress.
I love Discus but Im afraid I might kill them with temperature fluctuation when doing the massive water changes I tend to do.
We do a lot of massive water changes on Discus. If you get the temperature close, you'll probably be OK.
I've taken over the Discus care for the time being... They did well for us for a while, but I think I've tied their recent decline to their actual owner forgetting to feed them often enough... siiiiiiiiiiiiiiiigh.
We're going to have to go out to Hans and get some more at some point, too.
I now use an infrared temperature gun when doing water changes. It was only $20, and I can measure both the temp of the tank water, and the temp of the water being added to make sure they're close. I usually used the hand on faucet method to gauge temp, but realized that wasn't accurate and sometimes led to problems. I do large water changes on my discus tanks, and a few other heated tanks, but rarely have a problem anymore. They're also pretty forgiving, I've seen the temp drop almost 10 degrees, and the fish weren't happy, but never got sick.
Has the speaker for the October meeting been announced? Looking forward to finally making it to another meeting.
Thanks! Mike is awesome! Got to speak with him a few times up in Mass.
He's a cool dude! I'm glad you're excited to hear his talk.


text:
{{Infobox Cinéma (personnalité)
| date de mise à jour  =
| couleur           = artiste
| nom               = Kay Panabaker
| image             = Academy Awards afterparty CUN Kay Panabaker.jpg
| taille image      = 230p
| légende           = Kay Panabaker en février 2007
| nom de naissance  = Stephanie Kay Panabaker
| surnom            =
| date de naissance =
| lieu de naissance = Orange, Texas, (États-Unis)
| nationalité       =  Américaine
| date de mort      =
| lieu de mort      =
| profession(s)     = ActriceModèle Photo
| films notables    = SummerlandSuper Hero FamilyLes experts| conjoint          =
| enfant            =
| site internet     =
| imdb              =
| récompense        =
}}

Stephanie Kay Panabaker, appelée Kay Panabaker, est une actrice américaine née le  à Orange (Texas).

Enfant star, elle est la sœur de l'actrice Danielle Panabaker.

Elle est révélée à la télévision, grâce aux rôles qu'elle occupe dans plusieurs séries télévisées : Nikki Westerly dans la dramatique Summerland (2004-2005), Debbie Berwick et Daphne Powell dans les fantastiques Phil du futur (2004-2005) et Super Hero Family (2010-2011) ainsi que celui de Lindsey Willows dans la policière Les Experts (2006-2011).

En 2012, elle décide cependant de se retirer du milieu du divertissement au profit d'une carrière dans la zoologie en travaillant pour les parcs Disney's Animal Kingdom.

 Biographie

 Enfance et formation
Kay, de son vrai nom Stephanie, est la fille de Donna (née Mayock) et de Harold Panabaker, elle déménage beaucoup durant son enfance. Elle part de Houston et suit ses parents à Philadelphie puis Atlanta et se découvre une passion pour le métier d'actrice à 8 ans.

Elle doit ses premiers pas sur scène à une pièce de théâtre intitulée The Herbal Bed, jouée en 1999 à Chicago.

Tout comme sa sœur, l'actrice Danielle Panabaker, elle termine ses études très tôt, le lycée à l'âge de 13 ans (en 2003) et empoche son diplôme universitaire (bac+2) à seulement 15 ans.

Elle s'envole, accompagnée de sa mère et de sa sœur, pour Los Angeles, en 2002.

 Carrière

 Débuts et révélation (années 2000)
Elle commence par le théâtre pour ensuite s'orienter vers la télévision.

À partir de 2002, elle accumule les apparitions à la télévision et obtient son premier rôle dans un film aux côtés de Kiefer Sutherland pour le drame Dead Heat - Pari à haut risque.

Il faut attendre 2004 pour qu'elle décroche son premier rôle important à la télévision, lorsqu'elle rejoint la série dramatique Summerland, où elle joue aux côtés de Jesse McCartney et Lori Loughlin, avec qui la jeune actrice déclarera adorer travailler. Dans le même temps, elle obtient un rôle récurrent dans la série fantastique destinée à une jeune audience, Phil du futur.

Cette double exposition lui permet de remporter le Young Artist Awards de la meilleure jeune actrice dans une série télévisée pour Summerland, et d'être en lice, pour le même prix, grâce à Phil du futur.

Entre 2005 et 2009, elle joue dans de nombreux téléfilms. En 2005, elle est notamment la version jeune du personnage incarné par sa sœur, Danielle Panabaker, dans le téléfilm dramatique Trop jeune pour être mère avec Jane Krakowski. La même année, elle est l'héroïne de la comédie familiale Calvin et Tyco avec Kyle Massey, révélé par Phénomène Raven.

En 2006, elle porte le téléfilm Disney Channel, Le Journal de Jaimie, qui lui vaut une proposition pour le Young Artist Awards de la meilleure jeune actrice dans un téléfilm.

L'année suivante, elle est l'un des premiers rôles du drame Moondance Alexander avec Don Johnson et dans lequel elle retrouve Lori Loughlin ainsi que de la comédie Nancy Drew secondant la jeune star montante Emma Roberts. Des rôles qui lui offrent une nouvelle opportunité de prétendre pour un prix lors des Young Artist Awards. Elle est aussi vedette, aux côtés de Cole Sprouse et Dylan Sprouse du téléfilm pour enfants Le Prince et le Pauvre.

Sans jamais jouer aux côtés de sa sœur, les deux actrices se croisent pourtant sur les plateaux de séries télévisées dans lesquelles elle apparaissent comme Grey's Anatomy, Médium, New York, unité spéciale...

Côté grand écran, c'est en 2009 qu'elle se dévoile au plus grand nombre dans la comédie musicale Fame, remake du célèbre Fame des années 1980, où elle incarne Jenny.

 Télévision et retraite de comédienne (années 2010)
En 2010, elle joue la version jeune du personnage incarné par Calista Flockhart dans deux épisodes de la série dramatique Brothers and Sisters. La même année, elle rejoint surtout la distribution principale de la série fantastique Super Hero Family où elle incarne la fille Daphney Powell aux côtés de Michael Chiklis, Julie Benz et Jimmy Bennett. Cependant, les mauvaises audiences et les critiques très mitigées ne permettent pas au programme de dépasser le cap d'une saison de vingt épisodes.

Elle termine sa carrière en jouant dans le téléfilm d'ABC Family, Le Mur de l'humiliation et en prêtant sa voix à un personnage du film Le Chihuahua de Beverly Hills 3. En effet, Kay prend sa retraite du métier d'actrice en 2012 afin d'étudier et se consacrer à la zoologie, à l'UCLA. Elle travaille désormais comme soigneuse d'animaux à Disney's Animal Kingdom.

 Filmographie

 Cinéma

 Courts métrages

 2001 : Temptation de Roman Güttinger : Jamie Savini

 Longs métrages
2001 : Monstres et Cie de Pete Docter, David Silverman et Lee Unkrich : Voix additionnelles
2002 : Dead Heat de Mark Malone : Sam
2007 : Moondance Alexander de Michael Damian : Moondance Alexander
2007 : Nancy Drew d'Andrew Fleming : Georgie Fayne
2009 : Fame de Kevin Tancharoen : Jenny Garrison
2010 : The Lake Effect de Tara Miele : Celia
2011 : Little Birds de Elgin James : Alison
2012 : Le Chihuahua de Beverly Hills 3 de Lev L. Spiro : Rosa (voix, vidéofilm)

 Télévision

 Séries télévisées
2002 : Port Charles : Sara (1 épisode)
2002 : Urgences (ER) : Melissa Rue (1 épisode)
2002 : Sept à la maison : Alice Brand (saison 7, épisode 6)
2002 : Angel : La fille (2 épisodes)
2003 : Division d'élite (The Division) : Susie Jenkins (1 épisode)
2003 :  : Carrie Bauer (1 épisode)
2005 : Médium (Medium) : Elisha (1 épisode)
2004 - 2005 : Summerland : Nikki Westerly (rôle principal - 26 épisodes)
2004 - 2005 : Phil du futur (Phil of the Future) : Debbie Berwick (rôle récurrent - 15 épisodes)
2006 : American Dragon: Jake Long : Cheerleader Lacey (1 épisode)
2006 - 2011 : Les Experts (CSI: Crime Scene Investigation) : Lindsey Willows (rôle récurrent - 5 épisodes)
2007 : The Winner : Vivica (1 épisode)
2007 : Mon oncle Charlie (Two and a Half Men) : Sophie (1 épisode)
2007 : La Vie de palace de Zack et Cody (The Suite Life of Zack and Cody) : Amber (1 épisode)
2007 : Weeds : Amelia (1 épisode)
2007 : Boston Justice (Boston Legal) : Abby Holt (1 épisode)
2007 : Ghost Whisperer : Marlo Sinclair (saison 3, épisode 8)
2008 : Grey's Anatomy : Emma Anderson (saison 5, épisode 10)
2009 : Lie to Me : Emily Lightman (saison 1, épisode 1 - scènes coupées)
2009 : Mental : Aysnley Skoff (1 épisode)
2010 : Brothers & Sisters : Kitty Walker, jeune (2 épisodes)
2010 - 2011 : Super Hero Family : Daphne Powell (rôle principal - 20 épisodes)
2011 : New York, unité spéciale : Vicki Harris (saison 13, épisode 10)

 Téléfilms
 2005 : Trop jeune pour être mère de Peter Werner : Macy, jeune (non créditée)
 2005 : Calvin et Tyco (Life Is Ruff) de Charles Haid : Emily Watson
 2006 : Le Journal de Jaimie (Read It and Weep) de Paul Hoen : Jamie Bartlett
 2007 : L'Amour d'un père (Custody) de Nadia Tass : Amanda
 2007 : Le Prince et le Pauvre de James Quattrochi : Elizabeth
 2007 : Zip de Richard Shepard : Ellie Stringer
 2008 : Happy Campers de Gil Junger : Dylan
 2009 : A Marriage de Marshall Herskovitz : Maddy Gabriel
 2010 : L'Esprit d'une autre (Secret in the Walls) de Christopher Leitch : Lizzie
 2011 : Le Mur de l'humiliation (Cyberbully) de Charles Binamé : Samantha Caldone

 Distinctions
Sauf indication contraire ou complémentaire, les informations mentionnées dans cette section proviennent de la base de données IMDb.

 Récompenses
 Dixie Film Festival 2007 : meilleure actrice pour Moondance Alexander Temecula Valley International Film Festival 2007 : Rising Star Award
 Phoenix Film Festival 2011 : meilleure distribution pour The Lake Effect Young Artist Awards 2005 : meilleure performance par une jeune actrice dans une série télévisée pour Summerland Nominations
 Young Artist Awards 2003 : meilleure performance par une jeune actrice invitée dans une série télévisée dramatique pour Urgences Young Artist Awards 2004 : meilleure performance par une jeune actrice dans une publicité pour Anti-Smoking PSA Young Artist Awards 2005 : meilleure performance par une jeune actrice dans une série télévisée pour Phil du futur Young Artist Awards 2007 : meilleure performance par une jeune actrice dans un téléfilm ou une mini-série pour Le journal de Jaimie Young Artist Awards 2008 : meilleure performance par une jeune actrice dans un film pour Moondance Alexander et meilleure performance par une jeune distribution dans un film pour Nancy Drew''

Notes et références

Liens externes

Actrice américaine
Actrice Disney
Zoologiste américain du XXIe siècle
Enfant acteur américain
Naissance en  mai 1990
Naissance à Orange (Texas)
Étudiant de l'université de Californie à Los Angeles

redpajama_set_name: RedPajamaWikipedia


A pie and a couple of good cheeses and tiramisu; this was our impromptu plan for dinner last Saturday night. We asked another family over and happily, they were free. I always feel defiant about entertaining at this time of year because the fact is that it's never going to be as easy and carefree as having people visit during the warmer months – so I feel like we're kind of sticking it to winter. We can offer comfort food and throw rugs and a movie for the kids while the adults chat over dessert in the eat-in kitchen and while it's not as effortless and relaxed as summertime entertaining it's got an ambience of its own.
On Friday my husband took the day off work and we took the kids to Taronga Zoo. It was a beautifully mild day, and being the last official day of the school holidays probably also contributed to it being super crowded there. The kids held up well. One really didn't enjoy the lack of space. There was a minimum of complaining about the required walking around, and I think that only came from one of the littler ones near the end of the visit.
I go out to things like this with no illusions anymore that everyone in my family is going to have a good time, so it doesn't bother me if everyone isn't 100% thrilled with whatever we do: This rated pretty well on the Rodrigues family outing meter, but not stunningly well so I figure we're good for a zoo visit for another three years or so. I didn't take many photos, but I seem to always need to take one of the giraffes whenever I see them, hence the photo at the top of the post.
Sunday was the feast of Our Lady of Mt Carmel, but it wasn't mentioned at Mass and I forgot about it until late in the day. I celebrated with left-over tiramisu while reading the readings of the day from the Divine Office before bed.
I hope your weekend went well – it's back to school and work today!


IFRS Standards are required for domestic public companies IFRS Standards are required for listed companies, large unlisted companies, and state-owned companies.
Superintendencia de Compañías del Ecuador [Companies' Supervisory Authority of Ecuador].
The Companies' Supervisory Authority is the institution that controls, oversees, and promotes the securities markets and business sector by providing the appropriate regulatory framework and services. As such it contributes to the confidence in, and transparency of, business activities in Ecuador.
Ecuador has already adopted IFRS Standards for all or some companies.
IFRS Standards are mandatory for listed companies other than financial institutions and for other companies under the control/supervision of the Companies Supervisory Authority. Banks, insurance companies, and other financial institutions that are under the control/supervision of the Superintendency of Banks and Insurance Companies must use standards issued by that regulator.
Since 1 January 2010, all companies subject to the requirements of the Securities Act and all other companies required by law to have an external audit have been required to use IFRS Standards.
Since 1 January 2011, all companies with assets greater than US$ 4,000,000 at 31 December 2007; holding companies and consolidated groups; state-owned entities; and foreign-invested entities have been required to use IFRS Standards.
— Total number of employees less than 200 (annual weighted average).
Yes, all domestic companies whose securities trade in a public market other than financial institutions are required to use IFRS Standards.
Companies required by law to have an external audit must use IFRS Standards.
Companies with assets greater than US$ 4,000,000 at 31 December 2007; holding companies and consolidated groups; state-owned entities; and foreign-invested entities.
Permitted for other companies. Some companies may choose the IFRS for SMEs Standard.
IFRS Standards as issued by the Board, ie standards and amendments are adopted/endorsed as and when issued by the IASB.
IFRS Standards were adopted by Resolution No. 2008.11.20 08.G.DSC.010 issued by the Superintendent of Companies.
New and amended IFRS Standards become requirements automatically under Resolution No. 2008.11.20 08.G.DSC.010 issued by the Superintendent of Companies.
Yes. Ecuador has adopted the IFRS for SMEs Standard effective in 2012.
Total number of employees less than 200 (annual weighted average).


96% of executives consider creativity essential as a core competency.
Only 23% of them managed to integrate it into their company.
Without creativity there is no innovation. " – Philip Kotler, The bible of innovation.
Creativity alone does not generate value, but innovation does.
Innovation is transforming ideas into new solutions, processes, products, services and business models. Innovation is a process that is unstructured, difficult to manage and measure, and requires creativity to exist.
Digital transformation is a great reality, and we are only at the beginning of this irreversible process. Is your company ready to deal with digital transformation? What are your strategies to take your organization to the digital world?
I help organizations structure the process of managing innovation and creativity. Using important tools like Lean Startup, Thinking Design, Business Model Canvas, innovation management models, team creativity tools, among others, we work the teams innovation skills.
Contact me by the form, or email: adm.lhsouza@gmail.com .


text:
Home Nuclear Energy Platts Survey:High Capital Costs and Maintaining Public Confidence Citedas Greatest ChallengesFacing European...
Platts Survey:High Capital Costs and Maintaining Public Confidence Citedas Greatest ChallengesFacing European Nuclear Power Markets
High capital costs and maintaining public confidence are seen as the greatest challenges facing the European nuclear power industry, according to a recent survey conducted by Platts, a leading global energy, petrochemical and metals information provider. The survey included more than 100utilities, builders, consultancies, and regulators in Europe and precedes the eighth annual Platts European Nuclear Power Conference set for June 26-27 in Warsaw, Poland.
Political risk, long construction periods, regulatory uncertainty and safety concerns were also highlighted as key hurdles before the Continent's nuclear power companies.
"While most of these challenges are traditional to the industry and likely always will be, they'll likely be heightened as new units, particularly those using new designs, are built," said Platts Chief Editor of nuclear publications Tom Harrison, who reviewed the survey results. "Currently these challenges are being viewed in a particular context, one of: increased concerns about climate change, the pursuit of energy diversity, cost/benefit of competing generating sources, and attention to safety and its costs in the wake of the 2011 Fukushima nuclear accident."
A newer aspect to these challenges, Harrison explained, is that reactor vendors and other suppliers competing for new export opportunities are exploring new ways of packaging deals as nuclear power programs are introduced in other countries.
Industry supporters and detractors are expected to watch closely the first new nuclear projects in Europe to see how they fare as they encounter those political, financial, regulatory and safety issues.
When asked about the future of nuclear power capacity expansion in Europe, 80% of respondents said that nuclear power would succeed in gaining a larger share of the Continent's overall power generation mix.
"The sector is at a critical juncture, with opportunities for growth, but with key challenges and uncertainties that must be overcome in terms of regulatory structure, human resources, and financing arrangements in the next few years," said one survey respondent.
These and other topics will be discussed in depth at the two-day Platts European Nuclear Power Conference,which will feature keynote addresses, panel discussions and outlook presentations from notable speakers including the former Prime Minster of Poland Jerzy Buzek and government officials from Poland, European Commission, U.K., Malaysia and China.
A host of private industry representatives are also slated to offer outlook presentations at the June conference, including executives from PGE EJ 1 and PGE Energia Jadrowa, EDF Energy, Vattenfall, CEZ, GE Hitachi, Westinghouse, AREVA and Rolls-Royce, among others. For a complete listing of speakers and for full schedule details, see the conference agenda.
Corporate and industry executives may register to attend the Platts European Nuclear Power Conference at thegeneral registration link. Accredited media may attend the conference as guests of Platts by pre-registering at this link.
For more information on Platts European Nuclear Power Conference or nuclear power, visit the Platts website www.platts.com.
About Platts: Founded in 1909, Platts is a leading global provider of energy, petrochemicals, metals and agriculture information and a premier source of benchmark prices for the physical and futures markets. Platts' news, pricing, analytics, commentary and conferences help customers make better-informed trading and business decisions and help the markets operate with greater transparency and efficiency. Customers in more than 150 countries benefit from Platts' coverage of the biofuels, carbon emissions, coal, electricity, oil, natural gas, metals, nuclear power, petrochemical, shipping and sugarmarkets. A division of McGraw Hill Financial (NYSE: MHP), Platts is headquartered in New York with approximately 900 employees in more than 15 offices worldwide. Additional information is available at http://www.platts.com.
About McGraw Hill Financial: McGraw Hill Financial (NYSE: MHP), a financial intelligence company, is a leader in credit ratings, benchmarks and analytics for the global capital and commodity markets. Iconic brands include: Standard & Poor's Ratings Services, S&P Capital IQ, S&P Dow Jones Indices, Platts, CRISIL, J.D. Power & Associates, McGraw Hill Construction and Aviation Week. The Company has approximately 17,000 employees in 27 countries. Additional information is available at www.mhfi.com.
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It doesn´t matter if you arrive on a bike, by car, on a bicycle, or even on foot. The program will entertain everyone.
Euro Bike Fest area is located under the "Pálava Hills" on more than twenty hectares in the vicinity of "Mušov lakes".
Enjoy a great program, stocked bars, shopping zone and also a lot of friends.


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Tuskegee Airmen's Memorial Unveiled In Sewickley
By Bob Allen September 15, 2013 at 6:51 pm
Filed Under:African American, Aviators, Bob Allen, History, Memorial, Monument, Sewickley, Tuskegee Airmen, World War II, WWII
SEWICKLEY (KDKA) — It was a day that some World War II veterans thought they would never live to see: the dedication and unveiling of Tuskegee Airmen's Memorial of Greater Pittsburgh.
The monument honors the nation's first African American aviators who served in the military.
"The city of Sewickley, the city of Pittsburgh, the whole state and the country is seeing something that is utterly totally truthful and I'm proud to be a part of it," James Cotten said.
Cotten is one the more than 100 western Pennsylvania residents who became Tuskegee Airmen.
"It made the world a better place to be because it used the talents of everybody instead of a select racial group," Cotten said.
During the war, the Tuskegee Airmen became one of the most decorated squadrons, flying in more than 1,500 combat missions.
Three-hundred-fifty airmen and their widows received congressional medals
"We came to serve our country we came to prove that black Americans can and will serve their country equally as well as any other Americans," Cotten said.
But in serving their country they were subjected to Jim Crow laws' racial segregation within the military and legal and social prejudice.
"If we would have allowed those injustices to dwell with us, we would have never done the job we didn't come to get even we came to serve our country," Cotten said.


I was very small when this happened, I used to keep horses on a farm down Moors Lane with my nan. One day when we got the yard around 8 in the morning, one of the horses were out and there was tack and equipment everywhere. We called up the lady who's horse was out as nan was friends with her, she didn't want to come back on her own, she'd been at the yard around 5 in the morning before she went to work and heard footsteps and whistling, thinking it was the yard owner she shouted morning, when she had no reply she poked her head around the corner and no one was there, she dropped everything and left, not that I blame her!


Monster Jam® is the biggest live motorsport competition in the world. The television program has an extensive following, but the real fun happens during the event tour. Monster Jam trucks face off in two major competitions – racing and freestyle. In the traditional bracket racing, the first truck to cross the finish line is the winner. But, the race track is custom-designed with obstacles to soar over – or smash through! The show becomes more intense in the freestyle competition where you can see the outrageous and bold exhibitions these monster trucks can do. They're definitely the stars of the show. Your jaw will surely drop as the trucks show off their mind-blowing stunts and jumps! Imagine four-meter tall, five-ton beasts that are almost flying and crashing through metal boulders right before your very eyes. Nothing can get more exciting than this!
Lasting for about two hours, this is the coolest way to bond with your family. Scream your lungs out as you cheer for your favourite truck – or all of them! You won't be disappointed with what Monster Jam has prepared for you. This is as big as it gets as Monster Jam turns the Mall of Asia Arena to a challenging race track.
And it's totally safe, too!
Tell mom she shouldn't worry because the competition follows a strict set of rules, and the tracks are built by experts. Keep in mind that the Monster Jam truck drivers went through extensive training before they perfected those cyclones, donuts and wheelies!
These events are usually done in the U.S. or in Canada, but Filipino fans (yep, that's you guys) can watch them live on June 20 to 21 at the Mall of Asia Arena for the first time ever! Families also get the ultimate fan experience when they meet the amazingly talented drivers during the world-famous Party in the Pits. Get to know the Monster Jam superstars and have your official merchandise autographed. How cool is that? Ticket prices start at Php 850 only.
Seeing the monster truck drivers show off their skills is priceless. Video recording is also not allowed, so make sure you take this exclusive chance. Let mom and dad know that they can purchase tickets by calling SM Tickets (02) 470 2222 or visiting www.smtickets.com. For more information about Monster Jam show in Manila, visit www.monsterjam.com.ph today. Rev up, it's going to be one, electrifying show!


Discover the Markets of Trajan, one of the best preserved monumental complexes of ancient Romein the area of the Imperial Fora. A thrill ride through the heart of history, not to forget the Rome of ancient buildings, large civil engineering works created for will of emperors which often assumed an important role in the daily life of the ancient Romans.
Discover the Markets of Trajan, one of the best preserved monumental complexes of ancient Romein the area of the Imperial Fora. A thrill ride through the heart of history, not to forget the Rome of ancient buildings, large civil engineering works created for will of emperors which often assumed an important role in the daily life of the ancient Romans. Tours available Every day at 9:30am and 2:30pm Duration: 4 hours Group Size: Minimum 2 – Maximum 6 participants Tour price includes: Official guide Languages: English, Italian, Spanish, German or French Entrance tickets NOT included in tour price: Transportation from meeting point to starting point Transportation from the ending point to the meeting point Souvenirs, personal extras, tips Cancellation Policy: There will be no penalty for cancellations of excursion bookings communicated in writing at least three (3) days prior to the booked excursion date. No refund for further cancellations and no shows. Save time ordering: Add all tickets for museums and other services you want into your basket, then fill in the form and send your request. PLEASE NOTE: Immediately after submitting an order, you will receive an email with your order summary plus a second email confirming your successful payment. A confirmation email with links to the vouchers will be sent one business day after you place your order (Monday afternoon for orders submitted on Friday and during the weekend). Please make sure that your anti-spam filter does not block automatic emails from help@waf.it.


text:
package com.intenum.dbBackup;

import com.intenum.dbBackup.conf.Configuration;
import com.intenum.dbBackup.conf.EmailConfiguration;
import com.intenum.dbBackup.conf.LoggingConfiguration;
import com.intenum.dbBackup.conf.NotifyConfiguration;
import com.intenum.dbBackup.databases.DatabaseContext;
import com.intenum.dbBackup.databases.DatabaseJob;
import com.intenum.dbBackup.databases.DatabaseResult;
import com.intenum.dbBackup.jobs.Job;
import com.intenum.dbBackup.jobs.JobContext;
import com.intenum.dbBackup.utils.TemplateUtils;
import org.apache.commons.configuration.ConfigurationException;
import org.apache.commons.io.FileUtils;
import org.apache.commons.lang.StringUtils;
import org.apache.commons.mail.DefaultAuthenticator;
import org.apache.commons.mail.EmailException;
import org.apache.commons.mail.HtmlEmail;
import org.slf4j.Logger;
import org.slf4j.LoggerFactory;

import java.io.File;
import java.io.IOException;
import java.util.*;

/**
 * Created by ismail on 28.06.2015.
 */
public class DatabaseBackup
{
	private static final Logger LOGGER = LoggerFactory.getLogger( DatabaseBackup.class );

	private Configuration configuration = new Configuration();
	private HashMap< String, DatabaseJob > databases = new HashMap< String, DatabaseJob >();
	private String activeJobs;
	private String activeDatabases;
	private File tempDirectory;
	private File templateDirectory;
	private File confDirectory;
	private File logDirectory;

	private HashMap< String, Job > jobs = new HashMap< String, Job >();

	public String getActiveDatabases()
	{
		return activeDatabases;
	}

	public void setActiveDatabases( String activeDatabases )
	{
		this.activeDatabases = activeDatabases;
	}

	public Configuration getConfiguration()
	{
		return configuration;
	}

	public void setConfiguration( Configuration configuration )
	{
		this.configuration = configuration;
	}

	public String getActiveJobs()
	{
		return activeJobs;
	}

	public void setActiveJobs( String activeJobs )
	{
		this.activeJobs = activeJobs;
	}

	public HashMap< String, Job > getJobs()
	{
		return jobs;
	}

	public void setJobs( HashMap< String, Job > jobs )
	{
		this.jobs = jobs;
	}

	public HashMap< String, DatabaseJob > getDatabases()
	{
		return databases;
	}

	public void setDatabases( HashMap< String, DatabaseJob > databases )
	{
		this.databases = databases;
	}

	public File getLogDirectory()
	{
		return logDirectory;
	}

	public void setLogDirectory( File logDirectory )
	{
		this.logDirectory = logDirectory;
	}

	private void loggingOperations()
	{
		LoggingConfiguration logging = configuration.getLogging();
		if ( logging.getMaxFiles() < 1 )
		{
			return;
		}
		LOGGER.info( "Max allowed logging files {}", logging.getMaxFiles() );
		File[] files = logDirectory.listFiles();
		List< File > list = new ArrayList< File >();
		Collections.addAll( list, files );
		Collections.sort( list, new Comparator< File >()
		{
			public int compare( File o1, File o2 )
			{
				return  o1.lastModified() < o2.lastModified() ? 1 : -1;
			}
		} );
		int maxFiles = logging.getMaxFiles();
		for ( int i = maxFiles; i < list.size(); i++ )
		{
			File file = list.get( i );
			LOGGER.info( "Logging file will be deleted {}", file );
			file.delete();
		}
	}

	public void execute()
	{
		LOGGER.info( "STARTING DB-BACKUP" );
		LOGGER.info( "Reading properties file" );
		try
		{
			readProperties();
		}
		catch ( ConfigurationException e )
		{
			LOGGER.error( e.getMessage(), e );
		}
		catch ( IOException e )
		{
			LOGGER.error( e.getMessage(), e );
		}
		catch ( ClassNotFoundException e )
		{
			LOGGER.error( e.getMessage(), e );
		}

		if ( !validate() )
		{
			return;
		}

		loggingOperations();
		if(StringUtils.isEmpty( activeDatabases )){
			LOGGER.error( "There is no active databases. Please check example.properties in conf folder" );
			return;
		}
		LOGGER.info( "BACKUP STAGE [{}]", activeDatabases );
		String[] dbList = activeDatabases.split( "," );

		List< DatabaseResult > results = new ArrayList< DatabaseResult >();

		// run databases
		for ( String db : dbList )
		{
			db = db.trim();
			if ( StringUtils.isEmpty( db ) )
			{
				continue;
			}

			LOGGER.info( "{} >>>", db );
			DatabaseJob databaseJob = databases.get( db );
			if ( databaseJob == null )
			{
				LOGGER.error( "Database job not found. {}", db );
				continue;
			}
			DatabaseContext databaseContext = new DatabaseContext( configuration, tempDirectory );
			DatabaseResult result = databaseJob.execute( databaseContext );
			results.add( result );
		}

		if(StringUtils.isEmpty( activeJobs )){
			LOGGER.error( "There is no active jobs. Please check example.properties in conf folder" );
			return;
		}

		String[] jobList = activeJobs.split( "," );
		JobContext jobContext = new JobContext();
		jobContext.setDatabaseResults( results );

		LOGGER.info( "JOBS STAGE [{}]", activeJobs );
		for ( String job : jobList )
		{
			job = job.trim();
			if ( StringUtils.isEmpty( job ) )
			{
				continue;
			}
			LOGGER.info( "{} >>>", job );
			Job job1 = jobs.get( job );
			if ( job1 == null )
			{
				LOGGER.error( "Job not found. {}", job );
				continue;
			}

			job1.execute( jobContext );
		}
		LOGGER.info( "Finished jobs" );
		if ( configuration.getNotify().isEnabled() )
		{
			try
			{
				notifyReceivers();
			}
			catch ( EmailException e )
			{
				LOGGER.error( e.getMessage(), e );
			}
			catch ( IOException e )
			{
				LOGGER.error( e.getMessage(), e );
			}
		}

		LOGGER.info( "Completed all operations" );
	}

	private void readProperties() throws ConfigurationException, IOException, ClassNotFoundException
	{
		PropertiesReader propertiesReader = new PropertiesReader();
		propertiesReader.setDatabaseBackup( this );
		propertiesReader.read( new File( confDirectory, "main.properties" ) );
	}

	private void notifyReceivers() throws EmailException, IOException
	{
		HashMap< String, Object > map = new HashMap< String, Object >();
		HtmlEmail email = new HtmlEmail();
		EmailConfiguration emailSender = configuration.getEmailSender();

		email.setHostName( emailSender.getHost() );
		email.setSmtpPort( emailSender.getPort() );
		email.setAuthenticator( new DefaultAuthenticator( emailSender.getUsername(), emailSender.getPassword() ) );
		email.setSSLOnConnect( emailSender.isSsl() );
		email.setFrom( emailSender.getUsername() );
		NotifyConfiguration notify = configuration.getNotify();
		email.setSubject( notify.getSubject() );
		email.setHtmlMsg( TemplateUtils.template( FileUtils.readFileToString( new File( templateDirectory, "notify-success.vm" ) ), map ) );
		String[] receivers = notify.getReceivers().split( "[,;]" );
		email.addTo( receivers );
		email.send();
		LOGGER.info( "Notify emails sent to {}", notify.getReceivers() );
	}

	private boolean validate()
	{
		if ( configuration.getNotify().isEnabled() )
		{
			if ( !validateNotify() )
			{
				return false;
			}
		}
		return true;
	}

	private boolean validateNotify()
	{
		EmailConfiguration emailSender = configuration.getEmailSender();
		if ( StringUtils.isEmpty( emailSender.getHost() ) )
		{
			LOGGER.error( "Email sender host cannot be empty" );
			return false;
		}
		if ( emailSender.getPort() < 1 )
		{
			LOGGER.error( "Email sender port is invalid. Value : {}", emailSender.getPort() );
			return false;
		}
		if ( emailSender.getUsername() == null )
		{
			LOGGER.error( "Email sender username cannot be empty" );
			return false;
		}
		if ( emailSender.getPassword() == null )
		{
			LOGGER.error( "Email sender password cannot be empty" );
			return false;
		}
		return true;
	}

	public File getConfDirectory()
	{
		return confDirectory;
	}

	public void setConfDirectory( File confDirectory )
	{
		this.confDirectory = confDirectory;
	}

	public File getTempDirectory()
	{
		return tempDirectory;
	}

	public void setTempDirectory( File tempDirectory )
	{
		this.tempDirectory = tempDirectory;
	}

	public File getTemplateDirectory()
	{
		return templateDirectory;
	}

	public void setTemplateDirectory( File templateDirectory )
	{
		this.templateDirectory = templateDirectory;
	}
}

redpajama_set_name: RedPajamaGithub


Hello (to whoever is still checking out this space)!
It's been a good one month and more since this space was updated. February was a hectic month for me, way busier than any of the last of the couple of months.
The reason for my disappearance was cause I made the decision to return to the corporate world after a year's break from it. The opportunity presented itself late last year and after much contemplation, I decided to give the corporate world another shot. It's a niche industry, one that I'd never thought I would one day stepped into, which was why I decided to give it a try. After all, it's always good to learn more, no?
Returning to the corporate world meant making changes (plenty of it) to my lifestyle. No more late nights (3.00am bed time is non existent now), waking up before the sky lights up and clocking 9 hours daily. After enjoying a year of flexible schedule meant I had some difficulty adapting to this new lifestyle. A month on, I'm quite happy to say that my body has more or less adapted to this new lifestyle, though I have to admit that my bed really seems so much more comfortable in the morning.
Waking up at 6.00am daily meant that my energy dropped to a dangerously low level by the time I leave the office at 6.00pm. By the time I reached home, I'm all ready to wolf down dinner, shower, laze for a while and then hit the sack.
Weekends meant sleeping in late, doing house chores, catching up on reading, yoga and attending workshops. There were times when I was tired, I literally slept the whole Sunday (just like yesterday). To some, it's a waste of time to sleep the whole day but to me, it a must. Rest is more important to me than heading on. If I don't rest, it's only a matter that I'll fall sick again and that is not what I need now.
With this kind of schedule, it also meant that I had to sacrifice certain stuff, like blogging for instance. Much as I want to blog, my brain and body just wouldn't cooperate. And that explains my disappearance from here.
So will I be shutting this blog? The answer is a definite NO.
Writing and blogging is still one of my passion and there are plenty of memories here that I will never bear to shut it down.
Now that my body is more or less attuned to this new lifestyle, I'm also trying to work out a schedule where I hope I'll be able to blog at least twice a week.
And that's the end of this quick update. Till the next, have a great evening!


text:
Belgium: Jacobs Douwe Egberts to close Senseo factory
Home Europe
September 15, 2016 By Innovation Editor - Europe Jacobs Douwe Egberts In	Europe, Manufacture & Distribution, Non-Alcoholic Drinks
Jacobs Douwe Egberts (JDE), the world's leading 'pure play' coffee firm, is to shut its Senseo facility in Grimbergen, Belgium with the possible loss of 274 jobs, according to a report in Levensmiddelenkrant.
The factory, located in the Flemish half of the country, predominantly manufactures coffee pods, a category that is reported to have lost market share over recent years as the popularity of capsule formats has increased.
"It is with much regret that we have to announce our intention to close this facility", commented Jacobs Douwe Egberts operations director Luc Volatier in a press release. "Since opening in 1973, our plant in Grimbergen has played an important role in delivering our coffee business in Western Europe. While we appreciate and acknowledge the hard work of our Belgian employees, we believe this is a necessary step to strengthen our future business in the region".
Production at the site is expected to come to an end in early 2017.
Source: Levensmiddelenkrant


Melbourne Residential Real Estate - Move Straight into Brand New Apartment!
This two bedroom Eporo Apartment with 1 car park features floor to ceiling windows, allowing maximum natural light and ventilation, creating a vibrant and exciting living space. High ceilings for all living areas with state of the art finishes; creating a spacious and comfortable environment.
This apartment invites you to step in with a vibrant and welcoming entrance and lobby and stay for top notch city living at its best.
Close to the University of Melbourne, RMIT, QV Shopping Centre, Queen Victoria Market, Crown, Chinatown, Melbourne Central, Flagstaff Gardens, Legal precinct, Underground rail loop and trams, Entertainment and theatres.


"Science show Atradėjas" is kids parties in a modern and unconventional format.
It is an extraordinary science laboratory, where dreams come true.
Interactive science show Atradéjas is perfect for your Birthday party, corporate event and Graduation party!
Also is ideal for schools, nursery schools and public events!
Doctor of Technical Sciences supervises the know-hows and experiments. His positive feedback serves as a signal for us to introduce experiments in the program.
Materials with safety certificates are delivered to us by partners from Canada and the USA.
After the experiments perfect order is maintained on the site. For children, the possibility of slipping on the floor is excluded, and their clothing remains clean.
SCIENCE SHOW. ORGANIZATION OF KIDS PARTY.
Are you wondering about a way of holding a kids birthday party? The science show "Atradėjas" always has an original project to offer you. What we're talking about is the new format of kids parties – a science show. It is worth noting that it is not entirely correct to refer to this format as 'new'. In fact, in Canada and the United States, science show themed kids parties have been developed for quite a long time, and the interest in them is not waning. For such events, even a special term has been created – Edutainment (a combination of "education" and "entertainment").
At kids parties animators enact something like a stage play with real physical and chemical experiments. At the same time, the audience is actively involved in the process, as all contests for the kids party are designed for interactivity. Having felt like experimentalist scientists, children continue to show interest in science, numbers and formulas.
Adults enjoy the "Atradėjas" science show as well. This is due to the top level of organization of kids party. We purchase quality chemical props in the USA from reliable partners. The hosts' acting skills are pretty impressive too.
In other words, "Atradėjas" kids parties cause a keen interest of the audience of any age category. And if you're looking for kids birthday party ideas, then look no further – our show is just what you need. In addition to that, we've developed a package of unique programs, each of which being most suitable for a specific audience.
3 to 6 yos – a program for preschoolers, is perfect if you plan on holding a party in kindergarten. It contains simple experiments, the purpose of which is to slightly open the curtain of the world of science before the child.
7 to 9 yos – a program for elementary schoolers. Children of this age are often referred to as 'whyers' due to the constant questions. The party for schoolchildren is arranged in such an order that children get answers to many questions and their interest is further heightened.
10 to 13 yos – the program is designed for schoolchildren, who've experienced the fundamentals of the educational process. This age can become a period of growing disinterested in science, if studying physics and chemistry is just a tedious memorizing of textbook sections. Our science show will revive schoolchildren's interest in science.
14 and older – this program combines the most spectacular experiments, which will surprise even an especially picky audience.
Kids parties agency "Atradėjas" will give you a wonderful useful way of spending your leisure time and will exceed your expectations. For good measure, watch videos from kids birthday parties. We hold kids science shows anywhere in the territory of the Republic of Lithuania.


Since qualifying in 2012 Claire has worked with a number of managers in small, medium and large organisations helping them to coach their teams more effectively, develop their skills and tailored workshops around their needs. She has continually invested into her CPD with further study and is a treasurer of the 3 shires coaching group, she also recently published a book titled: 'Empowering Employee Engagement - How to Ignite your team for peak performance' which is centred around the coaching framework and tools that she has successfully applied to motivate employee performance.
After a successful 20 years as a television presenter, which includes presenting the ITV national news, Daybreak and Sky Sports News, Ali was approached to share her experience, and train young presenters and it was at this time that she discovered her passion for Coaching. Ali Shaw attained a distinction in her Personal Performance Diploma within a space of 8 months and since qualifying has already made significant strides in getting her Confidence Coaching business up and running, alongside investing into expanding her skillset with continual professional development.
Having won the 'best newcomer award' in 2015, Rita has gone from strength to strength and has continued to grow her business with her unique trademarked framework 'SAVVI' - to facilitate positive change. Rita has gone on to help businesses develop their people, identify blind spots in how they manage and run their businesses through the power of coaching. She has worked with smaller businesses and larger well known ones such as the met police, KFC and Hallmark care homes. Rita has also invested extensively into her CPD and is a member of a number of networking groups and membership bodies and recently won an award for 'best coach' at The BEST Business Women Awards.
Meg volunteers with an organisation called Active plus, who take wounded, injured and sick (WIS) military veterans on as volunteer facilitators. Clients come from a wide variety of sources, eg Mental Health organisations, self-referrals, Job Centre, GPs surgeries, local councils –with one thing in common – they are all at rock bottom. Through a combination of practical exercises and life-coaching principles, they learn to come to terms with their challenges and to believe in themselves again. Previously working with the RAF, Skill force and developing programmes for formerly homeless 16-25 yr olds Meg epitomises the benefits of coaching and is a role model for coaching for a cause.
Qualifying as an NLP Practitioner in 2013 and specialising in healthy recovery for 12 years, Miranda works with people with illness and disability challenges in order to live a life of possibility. Blending together her skills of training, health recovery coaching, nutritional planning and NLP, Miranda Is focused on developing health success plans for her clients. Having previously undergone her own health challenges she is able to emphasise with her clients and regularly runs Coaching groups to assist individuals to improve and overcome their health challenges.
Since qualifying in 2014, Christelle has specialised in coaching freelance translators and interpreters and gone on to promote coaching in the translation industry. Since completing her Personal Performance Diploma she has gone on to further her study, is an active member of The ICF and has completed a number of CPD activities. Having successfully given a number of talks in Norway, London and Prague on a variety of coaching topics, she was recently invited to write an article for the American Translators Association and was featured on their September/October issue of their Chronicle publication allowing her to spread awareness on coaching topics to over 13,000 people in 95 countries.
David works with both corporate and private clients across the UK and the world ranging from PR and logistics professionals, to start-up business owners and those from the film and theatre industries in the UK and Hollywood. His book 'The Buddha in me, the Buddha in you' was published by Penguin random house earlier this year helping many to explore the spiritual meaning in their lives. David has been featured on BBC radio London and written a feature about coaching tools for a health publication produced by Holland and Barrett and alongside his coaching and writing, David also uses his coaching skills in a voluntary capacity with a worldwide Buddhist peace movement.
We would also like to congratulate all those who were shortlisted for an International Coaching Award 2016, you are all an inspiration to The Coaching Industry and are making a real and lasting difference to the lives of others.


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The research goal of the Virtual Publishing Company is to build a fast processing, high quality, fully functional and customizable 3 dimensional publication-engine.
In a 3 dimensional publication, visual quality must be perfect, text must be sharp and continuous animation must be fluid. This puts a lot of work on the device processor to calculate and output a single frame in a fraction of a second, dozens of times in the span of a second and double that in stereoscopic 3D.
Attempting to write a 3D Publication-engine in a high-level programming language would result in wasting a lot of the processors time on unnecessary translation tasks. This processor time could be used instead to improve quality and speed by building the engine in the processor's native assembly language and machine code. This approach exploits the full power of the device processor by using pure optimized assembly instructions to squeeze out the best possible display quality very fast.
The most important elements that need fast processing in a 3D publication-engine are a 3D graphical page turn and a 3D font typesetter/text formatter. Both of these functions are processor intensive but are ideal for optimizing into processor machine code. Both page turn and fonts are driven by plotting and mixing pixels with efficient mathematical equations perfect for writing in assembly language to get super fast calculations.
The Virtual Publishing Company has developed a number of research models to show these critical functions of the 3D Publication. These are detailed later in this document together with links to download them for demonstrations.
The All the tools for working with 3D publications can be built in high-level programming languages; it is only the engine itself which requires hard wiring to the device processor.
The Virtual Publishing Company has made enormous progress in the 3D Publication Engine Research Project. The page turn and 3D typesetting program design and main algorithms have been fully worked out and tested in models. The aim now is to perfect the technologies and bind them together into an all purpose 3D publication engine that could be adapted for different devices and operating systems.
We are at the dawn of the 3D display age with virtual reality, 3D TV and 3D movies. This project anticipates 3D displays on phones, tablets and PCs being commonplace.