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Them Ol' Ghosts will perform at this year's Gretna Heritage Fest
Them Ol' Ghosts are here to haunt your soul with Southern rock
September 12, 2018 by: Amanda "Bonita" Mester	Leave a comment
Them Ol' Ghosts are a four-piece rock band with roots buried deep in Southern soul. Their 2017 debut, Renegade, was recorded off the grid in a makeshift studio in the backwoods of Mississippi. The extemporaneous recording process was worth it; Renegade is a magical piece of work, luscious beyond belief and groovy.
Fronted by vocalist and guitarist Theophile Bourgeois (best name ever?), who is also the proprietor and master artist at Oak Street Tattoo, Them Ol' Ghosts will put on the biggest performance of their career at Gretna Fest on September 29. There, he'll be joined by guitarist Justin Johnson, drummer Blair Champagne (best name ever?) and bassist Aaron Younce. Ahead of their performance, Bourgeois got insightful about their genesis, sound and plans for what promises to be an auspicious future.
How did the band come together?
I had been in different bands all through my teenage years (mostly metal bands actually, which is so crazy considering the current style we write). I remember my cousin's boyfriend telling me, "One day you're gonna grow out of this cookie monster shit." To which I responded with a swift "No way, man!" Little did I know I would one day be in my 30s with a wife and kids, way less angst and testosterone, a considerable amount of happiness, and zero desire to make a crowd of people "wreck the pit."
I decided I wanted to make a change and write music people actually want to see live as opposed to merely being subjected to, just to support a friend. I met Justin and after a couple times jamming together, we knew that there was a special symbiotic nature to our playing. I'm not a very technical player. I've studied music theory in college, and have applied it to piano and guitar but ask me what scale I'm playing and I'm pretty much out. Justin, on the other hand, is very technical, always studying, knows his shit, and knows all the names for whatever we're doing! Together we make one full guitar player I believe.
We played in a band called Sievers Drive for a few years before our drummer left and then spent the next year trying people out and just never found the right fit. Around that time, I was simultaneously starting a family and building my tattoo career, so music was put on the back burner as far as any professional capacity goes.
But I never stopped writing. Justin and I would get together periodically to jam and write, and we would play with drummers here and there but it just never clicked…
Fast forward about five years.
I had been tattooing this group of friends for a few months and this kid Blair would always come tag along. He wasn't even old enough to be in the shop. He was this clean cut kid with a tight ass fade and diamond studs in his ears. By all metrics we should NOT have hit it off. But he was funny and respectful, you know, the type of person you want around?
So over the course of him hanging around, he would mention that he was a drummer and he'd tell me "We should Jam one day, man!" Now, I've had this type of situation unfold poorly enough times in the past to be less than cautiously optimistic about blind jamming with people. At the time I really didn't have any free time between tattooing and family so I would politely say "Yea bud, one day!" with absolutely no real intention of ever taking him up on it. God that feels terrible to say out loud!
Around this time, I had started doing solo acoustic sets. I set up this Christmas Toy Drive and invited some other acoustic acts along to play and one of the acts asked if it was cool if he brought his drummer along. Turns out, that drummer was Blair! As soon as he got behind that kit, a feeling of regret washed over me. "How could I be so stupid? I missed the chance to have this guy in the band! Son of a bitch!"
He was a natural. His beats were visceral, his fills were spot on, so technical, but not flashy in a masturbatory way. As soon as they finished their set, I ran up and asked him to leave his kit on stage, because I had a plan…I was gonna throw a song at him that I knew he could nail and he would have no choice but to want to be in a band with me. I started "Mr. Officer," and he played it perfectly as I always heard it in my head! It was like we shared a brain. I knew that night that regardless of what he had to say, I was never going to stop playing music with this dude.
After jamming with Blair for a few weeks, it was time for him to meet Justin. We set up and started playing "Losing My Cool." Blair didn't know that Justin was already very familiar with the song, so as soon as Justin came in with his licks, Blair's eyes got as wide as they could and we shared that look, like "This is the band."
Thus began the search for a bass player. We had tried a few dudes here and there but never had quite the right fit. Then one day Justin came into practice raving about these guys at Strange Guitar works who had just done some work on his guitar. I went in a and asked if I could put up an ad for a bass player and, without missing a beat, Aaron (who worked there) said,"I play bass!" I didn't At the time, he was dying to play with a band. I sent him a link to some solo recordings and invited him to come jam. Now the fact that Aaron is just a stone-cold sweet heart was already enough to land him a spot in the band. I wasn't too worried about his abilities, because, I mean, if your whole life is building and repairing guitars I'd say it's safe to assume you can play. When we all got together for the first time, there was no question, we were whole! This dude could play, he was another responsible guy who like Justin, contributed so much of the technical aspect of music to the band.
I really feel the universe brought us together for something bigger than ourselves. Like we're Voltron or something.
From where do you source your inspiration?
Inspiration hits you from where you least expect it. It may be the way Otis Redding places his vocals right behind the beat, or the way Thin Lizzy's guitarists master harmonic arrangements. But I feel to be a successful artist, in whatever your medium may be, you need to consume as much as you can and be open to things you may not have thought you would like. Listen to music from all over the world, seek inspiration like water. Fully immerse yourself in your craft and be open to inspiration wherever it may hit you.
Music to us is such an integral part of what it is to be human. I look at it as an auditory manifestation of human emotion and every song out there is an extremely acute experience of one person who was able to translate that message through arranging sounds and crafting language in such a way as to resonate that experience with an audience. It's the most rewarding feeling to have strangers tell you how your lyrics have touched them. My songs are often very personal experiences and there's therapeutic value in that process. I know I've saved countless dollars on therapy by just writing music.
There is also a certain regional aspect to our sound, which is why I add the "Southern" sub genre to our title. I don't think of us as others might think of "Southern" music. We're not out here singing about whiskey and motorcycles or trucks or anything. For me, a big source of inspiration is the romance of South Louisiana. I live in a small town outside of Lafitte, called Barataria. My backyard is the swamp, It's home to me, there's such rich cultural currency and unending inspiration here. The swamp is my muse and I could never escape her charm.
Renegade by Them Ol' Ghosts
What was the recording process like for Renegade?
The recording for Renegade was one of the top 5 experiences of my life. I remember this documentary about The Band's album "Songs from Big Pink" where they just turned this big house in the woods into a recording studio. It looked to me like the only way to cut a record. My dad has some hunting property in Monticello, Mississippi with this beautiful cabin overlooking a bluff on a river and it was a no-brainer: We had to make this the studio. So I convinced my good friend Ryan Tousel of Studio 13/ Shugali Productions to pack up his perfectly capable recording studio, leave his family for a weekend and move it all to the middle of nowhere to set up a make shift studio in the woods.
After pulling into the wrong house and encountering a neighbor with a loaded gun in his hand, Ryan made it to the cabin and the whole weekend was pure magic.
We got Blair's drums down pretty quick and worked on honing in our tone and finalizing parts in the night hours between tracking. Aaron being the all-pro musician he is, knocked his parts out in no time and went all the way back home to tech for Leo Nocentelli at Jazz Fest that night and came back up the next day just to be there. His parts were done. He had every reason to stay home, but didn't. That's the type of thing that really makes you love someone.
Justin and I worked on guitar harmonies all through the night, and when we did sleep, we slept with shirts over our mouths because there were HUGE spiders all over the place.
When it came time to track vocals I had originally set up in a room by myself, which I loved because I was a little self conscious of singing a cappella in a room full of buddies. That ended quickly when Ryan didn't like the sound at all. So he threw me right in the middle of the cabin with everyone. At first I was dreading the thought of them sitting there listening to me sing but there was this moment where this orange hunting vest caught my eye that I hadn't noticed before. It had this really cool Native American Chief airbrushed on it and it was framed in fancy cursive letters that read "Chief Running Black Toe." This was my late Paw Paw Theophile's hunting vest. Everybody called him Black, and it was like a sign that hit me. I knew I had to throw that vest on and record these vocals with the help of Ol' Black Toe. The band being the group of angels that they are were super supportive and made me feel really OK with the fact that, while I could hear everything in my headphones, all they could hear was me singing my heart out in nothing but some gym shorts and an epic hunting vest from my Paw Paw.
What plans do you have for future recordings?
We actually just went up to Bogalusa to cut two new tracks for a vinyl release. These songs explore more of our rock n roll/ progressive side. We managed to track some piano with the same piano that Kansas played on "Carry On Wayward Son" and ash in the same ash tray that Willie Nelson once used. So…that was pretty magical. We plan to release that soon as a limited edition 7" collector's vinyl. I'll be doing all of the album artwork myself and including a limited-edition art print inside of some of them. I enjoy joining my musical and visual arts careers where I can. I feel it's an added level to this project. From shirt designs, to album art. Maybe I'm a control freak or maybe i'm trying to save the band money. I'm not sure, but until the guys ask me to stop doing band doodles I'm going to keep them coming!
What do you look forward to showcasing at Gretna Fest? What do you feel your live performance brings to the table as opposed to other bands?
Gretna Fest will be our biggest show to date! We're all really excited for this one! 3/4 of the band are from the West Bank so we're fixing to show out for the home crowd, you know? We have a lot of new songs that we haven't performed yet that really go into new territory for us, but still fits well within the Them Ol' Ghosts realm. We're going to go out there and put it all out. When I sing those lyrics, I'm living those moments again. Whatever they are, good or bad, it's raw sincerity and it's about as genuine as it gets. You're going to see four guys who love each other, the music that they are able to make together, and the fans who support it, living the God damn dream!
renegadethem ol' ghoststheophile bourgeois
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The Cornell Daily Sun (https://cornellsun.com/2017/03/23/music-department-presents-song-of-the-land-poems-of-ishion-hutchinson/)
Music Department Presents "Song of the Land: Poems of Ishion Hutchinson"
By Victoria Horrocks | March 23, 2017
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Barnes Hall was packed for "Song of the Land: Poems of Ishion Hutchinson," a performance presented by the Music Department that put Hutchinson's poetry to compositions by graduate student composers. The performance presented a fusion of the old and the new, incorporating multiple forms of art to deliver a powerful concert. Guest artist Rachel Calloway, a mezzo soprano, sang a dramatic reading that conveyed the emotion communicated in the performance, and did so in a way that drew the audience in to share in the experience with her. This innovative project brought the respective virtues of literature and music into a symbiotic relationship that managed to showcase both the artistry of the music and the postmodern themes of Hutchinson's poetry.
The English department's Ishion Hutchinson writes narrative poetry that investigates colonialism through his depictions of landscape and the emotional weight of colonial history. He was most recently the recipient of the National Book Critics Circle Award for his collection of poetry House of Lords and Commons, but has also won the PEN/Joyce Osterweil Award for his collection Far District. In a similar style to the recently-deceased Derek Walcott, Hutchinson writes simple but profound prose that commands the emotion of the reader. The performance, which featured four of Hutchinson's poems, began with a tribute to Walcott with his poem "The Season of Phantasmal Passing." While not directly related to the performance, it introduced the themes of love, temporality and passing that pervaded the works of the poets and the musicians in the concert.
Throughout each piece, the natural rhythm of the poetry blended with the rhythm of the music and the dramatic performance of Calloway. The complementary relationship between mediums of art allowed the emotion evoked by the music to reflect the emotion of the poetry. One piece that was particularly striking was "Sharp: Bones Be Still." In this piece, Hutchinson's writing came alive, and brought with it provocative images of death and migration. The poem's themes of immigration and sacrifice draw on the image of the Middle Passage with lines such as "undead, fathers' bones, / make the Atlantic your home." This motif of the sea pervades the poetry, but was fostered in the performance by the music. The chaotic percussion mimicked the tumultuousness of the sea in addition to the turbulent emotions of migration. As "the sea swells," the music, too, crescendoed. This relationship brought the writing and the music into a harmony that, though distinct, allowed both art forms to complement the other.
While the concert was largely defined by its dramatic performance, it was also marked by the fusion of the old and the new, the classic and the postmodern. Hutchinson's contemporary style, blended with the classical feeling of the music, allowed not only for a blending of art forms, but also a blending of ages. Whether through the use of technology as a part of the musical production, or through the juxtaposition between the music and the writing, the concert was a refreshing take on what music and literature are capable of, both as distinct entities and in regards to each other.
Victoria Horrocks is a freshman in the College of Arts and Sciences. She can be reached at [email protected]
Healers and Protesters: Jamila Woods, SadoSan and Paulitics
By Sofia Hu March 27, 2017
Even before Jamila Woods stepped on stage, you could tell it was going to be an incredible night. At first, the Risley dining hall seemed too stiff of a venue for a show that celebrated black artists as healers and protesters (after all, the room is modeled after the Christ Church Refractory at Oxford), but openers Paulitics and SadoSan brought energetic and fun tracks that made the somber portrait of A.D. White peering over their shoulders appear ridiculously irrelevant.
Blind Spots and Bottom Boys: A Night of Eclectic Rock
By Jacob Kruger March 24, 2017
It was St. Patrick's day and the Haunt is a bar, so there was a crowd.

redpajama_set_name: RedPajamaCommonCrawl


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Adam Pally to Star in YouTube Red Comedy From Happy Endings Creator
By Michael Ausiello / April 30 2018, 9:00 AM PDT
It's not a Happy Endings revival, but we'll take it! Adam Pally is reuniting with Happy Endings creator David Caspe on a half-hour comedy series for YouTube Red, TVLine has learned. READ MORE
Don Cheadle, Andrew Rannells to Star in Showtime Comedy Pilot Ball Street
By Dave Nemetz / September 7 2017, 2:31 PM PDT
Showtime is buying stock in a couple of blue-chip actors for their new Wall Street comedy.
Don Cheadle (House of Lies) and Andrew Rannells (Girls) have signed on to star in the half-hour comedy pilot Ball Street, TVLine has learned. READ MORE
Pilot News: Casey Wilson to Headline NBC's Marry Me, From Her Fiancé/Happy Endings EP
By Michael Slezak / January 28 2014, 12:31 PM PST
NBC is saying "I do" to Happy Endings vet Casey Wilson. READ MORE
Pilot News: NBC Orders Relationship Comedy From Happy Endings Creator David Caspe
By Michael Ausiello / January 8 2014, 1:32 PM PST
NBC and Happy Endings creator David Caspe are tying the knot.
The Peacock network has given a pilot order Marry Me, a single-camera comedy penned by Caspe.
The Mad About You-esque project centers on …READ MORE
Happy Endings Boss Teases Weddings & Break-Ups, Reacts to 'Odd' Save the Show Promo
By Vlada Gelman / March 29 2013, 6:05 AM PDT
Something ah-mah-zing is happening tonight at 8/7c on ABC: Happy Endings finally returns with new episodes!
But does the series' recent two-month break and a move to dreaded Friday night spell doom for the ratings-challenged cult comedy? READ MORE
Happy Endings Preview: Penny Finds Love, Dave and Alex Get Serious and Max Is Miseryable
By Vlada Gelman / October 22 2012, 5:13 PM PDT
Happy Endings is back for Season 3 this Tuesday (ABC, 9/8c), and while the show is still as hilarious as ever, change is in the air. Among the major developments: Alex and Dave are getting serious about their relationship (again), Penny is finally breaking out of her spinster rut, and Brad and Jane are swapping roles. READ MORE
Happy Endings Season 2 Scoop: Max Gets Serious, Megan Mullally Sings, and Time Travel!
By Vlada Gelman / September 28 2011, 6:30 AM PDT
Watch out hipsters and zombies — Happy Endings is back this Wednesday, Sept. 28, at 9:30/8:30c, right after Modern Family. But the ABC comedy isn't resting on its Season 1 laurels. No, the sophomore run will have more guest stars (Parks and Recreation scene stealer Megan Mullally!), more romance (Dave and Alex: Round 2?) and, of course, more hilarious adventures (did you see our Halloween preview?). READ MORE
Happy Endings Cast Previews Season 2's Very 'Wrong' Halloween Adventure
By Vlada Gelman / September 6 2011, 4:44 PM PDT
If you thought Happy Endings' brief Season 1 glimpse of Halloween was fun, you're in for a treat. The ABC comedy is going all out for this year's Trick or Treat installment. How much bigger and funnier will it be? Adam Pally puts it this way: "Double Snookis" – aka Max and Penny's costume last year – "was just the beginning." READ MORE


Construction of the national broadband network will begin next month, with all 30,000 villages lacking WiFi to be connected by mid-2017.
The Budget Bureau last week approved a budget of 15 billion baht for the two state telecom enterprises, TOT Plc and CAT Telecom, to develop the last mile of infrastructure for low-cost wireless broadband access in rural areas.
The cheap broadband internet service will offer minimum speeds of 20 megabits per second.
Col Sanpachai Huvanandana, acting president of CAT, said it planned to begin the equipment procurement process this month, and start installing broadband network in June.
CAT and TOT last month agreed upon an implementation plan to roll out the national broadband network in rural areas in tandem.
CAT will be responsible for the North and Northeast, using 45% of the investment budget. TOT, which will receive 55% of the budget, will handle the development of the national broadband network in the rest of the country.
The project will be divided into two phases, Col Sanpachai said. In the first phase, the enterprises plan to provide free wireless broadband service in public areas of each district. In the second, CAT and TOT will provide affordable tariff rates, lower than those of private mobile operators. However, the exact rates have yet to be finalised.
He said CAT Telecom would also provide fourth-generation (4G) wireless broadband service on its existing 850MHz spectrum in rural areas. TOT, meanwhile, will provide 4G on its existing 2300MHz spectrum in these areas.
Col Sanpachai said CAT hoped the project will attract other private broadband service providers to jointly develop the low-cost broadband infrastructure in order to extend service areas.
There are a total 79,000 villages in the country, 40,000 of which already have broadband internet access.
According to the Information and Communication Technology (ICT) Ministry's master plan for the development of a digital economy and digital society, a minimum download speed of 4Mbps will be available in all villages, 20Mbps in all schools and community areas and 100Mbps in provincial economic zones by 2020.
Gp Capt Somsak Khaosuwan, deputy permanent secretary at the ministry, said the hard infrastructure was among the six core strategies driving the digital economy policy to raise the country's competitiveness.
Gp Capt Somsai said the master plan outlined four missions. They are improving the country's competitiveness; creating equal access to ICT for all people, especially the disadvantaged; developing a knowledge workforce; and enhancing the effectiveness of e-government services with more safety and transparency.
There are six key strategies to achieve the missions: developing hard infrastructure; developing soft infrastructure; developing service infrastructure; digital economy acceleration; developing a digital society; and developing a digital workforce.
Hard infrastructure covers the national broadband network, national broadcast facilities, satellites, spectrum frequency management, international internet gateway and submarine cables.
Soft infrastructure involves data security protection, updated cyberlaws, e-transaction platform, cybersecurity measures and human resource development.
Digital economy acceleration aims to promote digital usage among small and medium enterprises to help enhance their effectiveness in the world marketplace as well as create cooperation among industrial sectors.


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Author Sara F. Hathaway
The Changing Earth
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Episode 279 S7-41
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Can We Restore Trust?
Hope on the Horizon Ch 41
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Trust in society and government institutions is critical for a smoothly functioning country. You must explore the multiple viewpoints of American citizens of all walks of life to understand their perspectives. During the Hope on the Horizon story, Erika comes home to a celebration because the Supreme General has renewed trust in the government. However, that is not the case in the United States today. The question is, how do we get it back?
Today we explore an article by the Atlantic titled Collapsing Levels of Trust are Devastating America. The author, David Brooks, argues that there have been many past moments of moral convulsions in the United States. He is unsure that Americans have the moral fortitude to come to a table to discuss issues without applying a centralized power. I harbor the same questions but would never agree to the application of centralized power. Good things never come from it. Let's break this article down.
Brooks and I can agree on many things. We both agree that there is a strong feeling of disgust in society. Trust in institutions is plummeting rapidly. Also, anger over the past and present is plaguing too many Americans. 2020 was the breaking moment with factions from all the extreme viewpoints shouting so loud the leaders could no longer ignore their voices.
In his article, Brooks spews his hatred for Trump all over the pages of his writing, but the thought exercise about how Trump did end up in the office is one that is worth exploring. It was utter distrust for the current political leaders that brought him forth. People wanted a complete outsider with no political experience.
Brooks argues that national consciousness transforms during these tumultuous periods, and new societal norms and beliefs arise, and there is an adjustment of power.
He goes on to explain that the Baby Boomers of the 50s and 60s grew up in a stable society where everyone looked forward to a vibrant economy and boundless opportunity. The convulsions in the 60s were based on unshackling from societal norms and coming together as a people.
Today's generations never experienced this security. They watched institutions fail and lie. Children grew up knowing that the opportunities were drying up, and they would not have the life their parents did—the world view as altered to one of negativity. Teachers taught us that people were a plague on the planet. Climate change was a direct product of this human threat. Prominent voices declared that technological advancements were also a threat to a society designed to destroy the traditional way of life.
The view went from an opportunity to a threat. Brooks argues these alterations are now turning group think from liberation to security, from freedom to equality, from individualism to collectivism, and from a sink or swim mentality to social justice. I believe this is a problem. The boomers' soft times created a new generation of weak individuals, scared of living and unable to take responsibility for their lives. Because of this, they are looking to a benevolent government for answers rather than taking risks and carving their destinies.
Brooks wonders, as I do, if we are in a state for renewal or decline? Will we rise to the challenge?
He explains how the twentieth century saw an end of brutal regimes and the beginning of unharnessed globalization. Capitalism, democracy, pluralism, diversity, and globalization were all gleefully embraced. People came together, and the walls came down. Classic Liberals believed that "individual freedom would blossom into a loosely networked democratic capitalistic world. Individualistic views supported the idea that society flourishes when unshackled from community and state, when they have the freedoms to be true to themselves. If everyone does their own thing, everything will work out for everyone.
I partially agree with these views. Unshackling is the way to encourage growth, and allowing individual freedom does work best. However, there are a couple of things to remember. The first thing is the values. If values are lost, people don't protect one another or our planet. Then, greed and corruption take over. Also, no system is going to be best for "everyone." Some people will inevitably fall through the cracks no matter what type of leadership system is in place.
Brooks, on the other hand, thinks these views were just naïve. He argues that we didn't know what a globalized economy would do to the world's working-class people. Brooks argues that people thought global mixing would breed harmony, but that didn't happen. He argues that everyone thought there would be an opportunity for all, but the elites pull up the ladders of opportunity behind themselves. Brooks finishes his argument with the belief that they were naïve that oligarchs wouldn't steal nations.
Enter the period that Brooks calls, The Trust Fall. He explains that people had confidence in one another not so long ago to do the right thing most of the time. He described the concept of linked destinies and shared moral values, where most people had the same norms. This environment creates a high trust society where people can organize quickly, take action, and make sacrifices for the common good. These societies have lower corruption rates and encourage entrepreneurship.
Brooks does not give a reason for this societal norm falling apart, but I have a suggestion. I believe that the lack of faith in God and the removal of religion from society encouraged the breakdown. It destroyed families and encouraged sinful lifestyles without respect for one another as fellow human beings.
Regardless of where it went wrong, the distrust has morphed into a feeling of "explosive distrust." Brooks explains that society currently doesn't just see those with different beliefs as incorrect but illegitimate. Only a third of Americans today believe that other people will do the right thing.
Brooks argues that an individual builds trust upon the number of people who have wronged you versus those who remain loyal. Those individuals in the lower economic classes have the most distrust of any segment of society, and fewer than one-third of Americans say it is the greatest country in the world.
I believe this is because of the cynical viewpoint that educators have forced upon us. Educators are not teaching about the freedoms that America provided to the world or that we are the beacon of hope for other nations.
Brooks argues that humans need security for survival. Current generations have faced financial insecurity and emotional insecurity because of the lack of two-parent households, identity insecurity because of the lack of socially defined traits, and social insecurity because of a constant worry over how society perceives each individual.
I would argue that all of these societal trends are created by corruption and push to establish a communist state in America. If you look at the goals presented to congress in the 60s, all of these items are on the list. The purpose of the elites has been to turn Americans into debt slaves. The removal of God made marriage less and less respected, disrupting household stability, and furthering economic instability. Another communist goal was to encourage moral disintegration and remove pride in oneself and the nation. When you have nothing to base your self-worth upon, you look to society for affirmation, but no one truly knows what anyone else is thinking. It is all speculation.
The distrust is spiraling out of control. The less you trust your institutions and your government, the more likely you are to believe that there is no one you can trust. You have to put on thick armor to make yourself feel safe. Brooks argues that there are high suicide rates because the lack of trust self destructs the brain. I think it is the lack of self-identity because of the removal of societal definitions and the lack of faith that the creator crafted you for a reason.
Explaining further, Brooks states that distrust makes people less willing to take a risk and reduces entrepreneurship. Groups face off against alternate groups, and political extremism abounds. I can see this point of view. However, I also think that media is just highlighting it more, and social media and search engine algorithms encourage polarization even more.
One thing Brooks and I do agree on is the institutions failed miserably during the pandemic. Brooks argues that the low trust groups took it the worst. Every aspect of society created distrust during this time. The institutions had mixed messages that no one could trust. He claims leadership failed, but I would argue that any leader up against the mainstream media's hatred would have had a tough go of it. People don't trust the testing or solutions. This distrust creates international turmoil and eventually collapses the institutions because no one will want to fund them or work for them. The lack of trust is getting worse. Many groups believe that ripping it all down is the only way to fix the problems.
Brooks goes on to explain why the lockdown didn't work. He blames it on Americans "going off the diet." I can't agree with this assumption. A two-hour flight was turned into a twenty-four-hour flight without the people's consent, and people wanted their lives back. Quarantine is for the sick, not the healthy, and society can't exist in a lockdowns situation where tyrannical leaders tell you when you can go out and what you have to wear while you do it. Brooks also places the blame upon society, without mentioning the removal of faith, the elitist corruption, or the power grab that is happening right now. He whitewashes it all with idealistic principles that use guilt to convince the reader that they should hand over their freedoms because society has become lost.
Brooks explains that we are experiencing some critical cultural shifts. Society is turning from risk to security. "Republicans have gone from free trade to closed borders." His assumption is not valid. Republicans believe that the country should limit immigration to those who do it legally. Trade can still be borderless, except when the trading partners are tipping the economic tables to take advantage of us. Brooks also claims that the neoliberal Dems have turned to security-based views like universal income and expanded welfare. He states that society is turning from achievement to equality. He argues that society is basing your value, not on your wealth, on the quality of your life. I agree with Brook's assessment of the trend; however, I don't think it's a trend toward social equality rather a balance of individual lifestyle to temper work and play. Society is turning from self towards society. Each of us is not concerned with the individual, rather the group's identity. My opinion is that he is wrong regarding a sudden turn to group identification. Throughout all of history, individuals have their identity and the identity within the group in every culture. Group identity is nothing new, but Brooks tries to use it as a way to convince people to forfeit their rights for those imposed by a command center.
Brooks claims that views are shifting from global to local. He claims distrust of institutions is causing a shift back to the community. I think this is a good thing, but I feel it is because people realized the value of a tight local community and how meaningful those relationships are after experiencing the disconnect of global penpals on a social media platform. Finally, America is turning from liberalism to activism. Brooks explains that the urge to raise your group above others will ensue because of the community withdrawal and the distrust of other communities.
After unpacking this article, my faith that we can restore trust in our government is not very high. Brooks explains that in the past, these moral convulsions led to responsibility, organization, and rebuilding. People focused on responsibility through community groups, and political reform abounded from it.
Like Brooks, I share concerns. His answer is that we need centralized power to control the people and make them come together. I don't have the answers, but I am sure that is not the solution. The centralized power is what the authors of the communist agenda for the United States presented to congress in the 60s. A dream that the communists have dreamt of for many years would come true. I believe the problem is centralized power. For too long, people have looked to the federal government to make laws and control every state's rules in the same way. However, the founders of our country never intended for the states to be identical. That is why we are the United States of America, not just America. Each state was supposed to have the power to govern the people of their state how they saw fit. If you didn't like how the state you were living in operated, you changed it or moved to a state that was more in line with your views. The more we try to force people to fit into the box, the more people will want to break out of it.
I'm interested to hear your solution. If you have a moment, drop me a note in the forum.
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Transcription factors of the basic helix–loop–helix (bHLH) class are involved in the determination of precursor cells towards neural (proneural) and other cell fates. The proneural members of this class constitute a particular subset of bHLH proteins that are arranged in a cascade that affects different stages of neuronal commitment and differentiation, and act in a combinatorial code along with other transcription factors to specify neuronal identity. Proneural proteins themselves are a target of regulation by ID and HES proteins among others, and are involved in setting up a negative feedback pathway of lateral inhibition involving NOTCH and DELTA signalling. In addition, the activities of bHLHs are also subject to control by posttranslational modification and degradation. Finally, recent analyses have begun to identify the direct downstream targets of bHLH genes in the nervous system, and this is shedding light on the mechanisms ensuring specificity of the individual bHLH proteins.
bHLH proneural transcription factors have multiple direct downstream transcriptional targets including other transcription factors, signal transducers and cytoskeletal modifiers.
bHLH proneural transcription factors act in a combinatorial code to confer neuronal subtype identity.
bHLH transcription factors are regulated posttranslationally by mechanisms including phosphorylation and ubiquitin‐mediated proteolysis.
bHLH proneural transcription factors have multiple downstream targets that orchestrate neural differentiation.
Negative regulators of bHLH proneural proteins such as HES and ID proteins act by dimerizing with and sequestering E protein partners.
Lateral inhibition mediated by the NOTCH–DELTA pathway limits the number of neurons that differentiate from the pool of neuronal precursors.
A typical cascade of proneural genes in a Drosophila external sense organ. The iroquois (Iro) genes positively regulate achaete (ac) and scute (sc), defining the proneural cluster. Hairy represses the proneural genes outside the cluster. Achaete and scute dimerize with daughterless (da) to drive asense (ase) expression leading to neural specification, but within the proneural cluster, the Notch pathway through activation of E(spl) repressors, limits the expression and function of ac and sc to a single cell. Extramachrochaete (emc), another pathway inhibitor, reinforces this pattern.
Model illustrating the interactions between the Notch pathway, the Xenopus NGN2 homologue X‐Ngnr‐1 and the Xenopus cyclin‐dependent kinase inhibitor Xic1, during primary neurogenesis in Xenopus (first published in Vernon et al., ). Xenopus Neurogenin, X‐Ngnr‐1, both upregulates Delta resulting in activation of Notch in the adjacent cell, and drives differentiation via transcriptional upregulation of Xenopus MyT1 (xMyT1) and NeuroD. The Xenopus cdki p27Xic1 stabilizes X‐Ngnr‐1, and potentiates the neuronal differentiation arm of this network. Reproduced from Vernon et al. .
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Dufton C, Marcora E, Chae JH et al. (2005) Context‐dependent regulation of NeuroD activity and protein accumulation. Molecular and Cellular Neuroscience 28: 727–736.
Fisher A and Caudy M (1998) The function of hairy‐related bHLH repressor proteins in cell fate decisions. BioEssays 20: 298–306.
Gohlke JM, Armant O, Parham FM et al. (2008) Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biology 6: 15.
Gomez‐Skarmeta JL and Modolell J (2002) Iroquois genes: genomic organization and function in vertebrate neural development. Current Opinion in Genetics and Development 12: 403–408.
Hand R, Bortone D, Mattar P et al. (2005) Phosphorylation of neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex. Neuron 48: 45–62.
Kageyama R, Ohtsuka T and Kobayashi T (2008) Roles of Hes genes in neural development. Development, Growth and Differentiation 50(suppl. 1): S97–S103.
Lee JE (1997) Basic helix‐loop‐helix genes in neural development. Current Opinion in Neurobiology 7: 13–20.
Lee S, Lee B, Lee JW and Lee SK (2009) Retinoid signaling and neurogenin2 function are coupled for the specification of spinal motor neurons through a chromatin modifier CBP. Neuron 62: 641–654.
Lee SK and Pfaff SL (2003) Synchronization of neurogenesis and motor neuron specification by direct coupling of bHLH and homeodomain transcription factors. Neuron 38: 731–745.
Lewis J (1996) Neurogenic genes and vertebrate neurogenesis. Current Opinion in Neurobiology 6: 3–10.
Longo A, Guanga GP and Rose RB (2008) Crystal structure of E47‐NeuroD1/beta2 bHLH domain–DNA complex: heterodimer selectivity and DNA recognition. Biochemistry 47: 218–229.
Ma YC, Song MR, Park JP et al. (2008) Regulation of motor neuron specification by phosphorylation of neurogenin 2. Neuron 58: 65–77.
Nguyen L, Besson A, Heng JI et al. (2006) p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes and Development 20: 1511–1524.
Powell LM and Jarman AP (2008) Context dependence of proneural bHLH proteins. Current Opinion in Genetics and Development 18: 411–417.
Seo S and Kroll KL (2006) Geminin's double life: chromatin connections that regulate transcription at the transition from proliferation to differentiation. Cell Cycle 5: 374–379.
Seo S, Lim JW, Yellajoshyula D, Chang LW and Kroll KL (2007) Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers. EMBO Journal 26: 5093–5108.
Shimojo H, Ohtsuka T and Kageyama R (2008) Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron 58: 52–64.
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Sugimori M, Nagao M, Bertrand N et al. (2007) Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord. Development 134: 1617–1629.
Vernon AE, Devine C and Philpott A (2003) The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus. Development 130: 85–92.
Vernon AE, Movassagh M, Horan I et al. (2006) Notch targets the Cdk inhibitor Xic1 to regulate differentiation but not the cell cycle in neurons. EMBO Reports 7: 643–648.
Vinals F, Reiriz J, Ambrosio S et al. (2004) BMP‐2 decreases Mash1 stability by increasing Id1 expression. EMBO Journal 23: 3527–3537.
Vosper JM, Fiore‐Heriche CS, Horan I et al. (2007) Regulation of neurogenin stability by ubiquitin‐mediated proteolysis. Biochemical Journal 407: 277–284.
Guillemot F (2007) Cell fate specification in the mammalian telencephalon. Progress in Neurobiology 83: 37–52.
Kageyama R, Ohtsuka T, Hatakeyama J and Ohsawa R (2005) Roles of bHLH genes in neural stem cell differentiation. Experimental Cell Research 306: 343–348.
Quan XJ and Hassan BA (2005) From skin to nerve: flies, vertebrates and the first helix. Cellular and Molecular Life Sciences 62: 2036–2049.
Yan RT, Ma W, Liang L and Wang SZ (2005) bHLH genes and retinal cell fate specification. Molecular Neurobiology 32: 157–171.


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Summer 2002 in the front yard.
Exercycle for Sale at the Moving Sale, late summer 2002.
The same, one rotation later.
Mina (topside) & Woozle (inside).
Wooden Giraffe at the Leipzig Zoo.
Two Years Before the Mast?
Matthew & friend Ann-Katrine vs. cotton candy at his school.
Outside the market behind our apartment house.
Leipzig Train Station (aka the Hot Bun House). Left: The World's Largest Freestanding Christian Menorah, and Right:on the carousel.


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Madonna Responds to Aretha Franklin Tribute Backlash
In an Instagram post congratulating video of the year winner Camila Cabello, addressed the controversy, and offered some context as to why she spoke about Franklin.
By Christi Carras
LOS ANGELES (Variety) – Madonna responded to backlash on Tuesday following her tribute to Aretha Franklin at the MTV Video Music Awards , saying she "did not intend to do a tribute to her," but was asked by MTV to "share any anecdotes" she had about the late singer.
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FILE PHOTO: Madonna performs "Nothing Compares 2 U" during her tribute to Prince at the 2016 Billboard Awards in Las Vegas
"Just to clarify: I was asked to present video of the year by MTV!," she wrote. "And then they asked me to share any anecdotes I had in my career connected to ! I shared a part of my journey and thanked Aretha for inspiring me along the way. I did not intend to do a tribute to her! That would be impossible in 2 minutes with all the noise and tinsel of an award show. I could never do her justice in this context or environment. Unfortunately most people have short attention spans, and are so quick to judge. I love Aretha!"
Im with the Winner!! The beautiful @camila_cabello ! So proud of her! ???. And just to clarify: I was asked to present video of the year by MTV! And then they asked me to share any anecdotes I had in my career connected to Aretha Franklin! I shared a part of my journey and thanked Aretha for inspiring me along the way. I did not intend to do a tribute to her! That would be impossible in 2 minutes with all the noise and tinsel of an award show. I could never do her justice in this context or environment. Unfortunately most people have short attention spans, and are so quick to judge. I love Aretha! R.E.S.P.E.C.T. ??. I Love Camilla! Congrats! I LOVE my dress! AND. I love-L O V E!! ♥ and there is nothing anyone can say or do that will change that. #vmas #postivevibes
A post shared by Madonna (@madonna) on Aug 21, 2018 at 9:23am PDT
Many took to Twitter to criticize Madonna on Monday night for her words about Franklin, who died at age 76 last week. After Madonna's speech, in which she spoke about the origins of her own career and how a failed audition singing Franklin's "(You Make Me Feel Like) A Natural Woman" launched her into pop stardom, Twitter users, including Charlamagne tha God, roasted her for focusing on herself.
"I'm so lost," Charlamagne wrote. "I thought Madonna was supposed to be paying homage to Aretha but all I heard was her paying homage to herself. HEAVY on the Mayonnaise…"
Madonna gave the widely criticized speech while presenting the most coveted award of the night — video of the year — which went to Cabello. Following Franklin's death, MTV asked Madonna to add a tribute to Franklin in her introduction.
Me: It's weird that #Madonna is doing a tribute to Aretha Franklin, but what's the worst that could happen?
Madonna: pic.twitter.com/DvfueYKgCu
— Brittany Stephanis (@bmstephanis) August 21, 2018
The pop star did mention Franklin by name toward the end of her speech, when she added, "I want to thank you, Aretha, for empowering all of us. R-E-S-P-E-C-T. Long live the queen."
In her Instagram post, Madonna referenced her final send-off and blamed viewers for being "quick to judge" and having "short attention spans." An accolade of some sort was expected at the show after individual tributes from musicians, actors, and more poured in following Franklin's death.
Singers Aretha Franklin and Stevie Wonder perform together during the finale of VH1's "Divas Live: T..
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Blue Cross bosses appeal over land for animal shelter
By Richard Cornwell
FELIXSTOWE: Bosses at the Blue Cross are to lodge an appeal over the county council's refusal to sell a piece of land needed to safeguard the future of the animal rescue centre.
Supporters of the shelter, in Walton High Street, Felixstowe, were left reeling after the council declined to negotiate over the site at the rear of the property.
Blue Cross officials agreed to keep the treasured centre open after a massive "save it" campaign spearheaded by the Evening Star, with 14,000 people signing a petition protesting at the closure threat and hundreds taking part in marches and rallies.
But officials said a �1million expansion and refurbishment project would be needed, and it was vital that more land was secured for a dog exercise area.
The council said it was unable to sell the land at present because of the uncertainty over the plans for a new �32million academy at the resort. The site is part of the area earmarked for the new school, although that area of land probably won't be needed.
Until the government decides if Felixstowe's academy in the Building Schools for the Future programme will continue, no sale can be considered.
Tom Crowley, chairman of the Complete the Dream fundraising campaign to raise the �1m needed for the centre's refurbishment, said campaigners had not given up over the land.
"The Blue Cross is to lodge an appeal over the refusal to sell the land and we will see what happens," said Mr Crowley.
"We can understand the uncertainty concerning the school plans and hopefully this will be resolved quickly.
"It is quite a small area of land and it is right at the back of the centre so it probably wouldn't form part of the school anyway."
Because the land is so vital the charity has delayed an official launch of the Complete the Dream appeal until the situation is clearer.
Campaigners have been "hugely disappointed" at the setback as it's the only way the shelter can stay on this site and provide the facilities desperately needed for the animals in its care, and if it cannot be bought, a new site may have to be found.
n Should the council release the land? Write to Your Letters, Evening Star, 30 Lower Brook Street, Ipswich IP4 1AN, or e-mail eveningstarletters@eveningstar.co.uk


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Betting and gambling industry donates £4.5 million to GambleAware
Posted on January 14, 2021 - Last Updated on January 18, 2023
by Andrew Boggs
1 Flutter Entertainment
2 Bet365
3 Casumo Services
4 Additional funding
5 The need for funds
The UK based gambling charity, GambleAware, has announced that betting and gambling operators have donated $4.5 million over the course of the first three quarters of the 2020-21 financial year.
Flutter Entertainment
The top donator from the betting and gambling industry was Flutter Entertainment. They donated a total of £874,000 in the first nine months of the financial year. Flutter is the holding company for a range of international brands and operations, including Paddy Power, Betfair, Pokerstars, Sky Bet, Sportsbet, FOX Bet, FanDuel, TVG, and Adjarabet. Many of the sports books that operate underneath Flutter offer odds on a number of esports.
Following closely behind, the operator that donated the second highest amount in the first three quarters of the financial year was Bet365. They donated £763,000, just over £100,000 less than Flutter Entertainment. Although, it should be noted that Bet365 has committed to donating a total of £1 million during the 2020-21 financial year. That would make them the top donor.
Like most British betting operators, Bet365 has its corporate headquarters in the UK and global offices in major gambling hubs like Gibraltar, Malta, Australia, and America. Much like the sportsbook's underneath Flutter Entertainment, Bet365 offers odds on esports.
Casumo Services
Casumo Services is a relatively new operator even in the online betting and gambling industry. It was only in the last five years that they received a licence from the UK Gambling Commission to operate in the UK. The company made two separate donations of £27,446 and £16,170.
As would be expected from a younger online betting company, they understand the importance of esports and offer odds on most of the major tournaments. In fact, they have even partnered with an esports organisation, Planet Odd. Planet Odd fields players in Counter-Strike: Global Offensive, Dota 2, and Hearthstone.
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Additional funding
GambleAware has also received additional funding from regulatory settlements agreed between the industry and the Gambling Commission. They received £3 million from William Hill after the company settled with the UK Gambling Commission regarding harm prevention and money laundering failures.
Another £5.8 million came from Betway. This was part of an £11.6 million settlement that the company had reached with the UK Gambling Commission. They had been found to have breached a number of social responsibility and money laundering regulations related to high-spending customers.
The need for funds
These donations will go towards GambleAware's safer gambling campaign. It is a two-year initiative that is currently running to raise public awareness of the risks associated with gambling. The initiative which was developed in partnership with the UK's Department for Digital, Culture, Media, and Sport will also see the operators contribute 0.1% of their gross gambling yield directly to GambleAware each year, to support its existing treatment commitments and to continue its independent research programme.
The funds will go towards treatment for problem gamblers as well as increasing the safer gambling messaging across their advertising, support dedicated campaigns, and review the content of all marketing, advertising, and sponsorship.
This sort of campaign is all the more important for operators who offer odds on esports in their sportsbooks. Regardless of the 28-year-old average age of the esports viewer, the fact that esports and video games, in general, have a younger audience means that many operators need to be at the top of their class when it comes to consumer safety.
Andrew Boggs
Andrew is a Northern Ireland based journalist with a passion for video games. His latest hobby is watching people speedrun Super Mario 64 and realising how bad he is at platformers.
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EsportsBets.com > Esports News > Betting and gambling industry donates £4.5 million to GambleAware


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Changing trends in pharmacology… p. 143
Bikash Medhi
Current advances in transdermal delivery of drugs for alzheimer's disease p. 145
Thuy Trang Nguyen, Vo Van Giau, Tuong Kha Vo
Alzheimer's disease (AD) is a common, progressive, fatal neurodegenerative disorder, which will play an increasingly important role both socially and financially in the aging populations. Treatments for AD show modest improvements in cognition and global functioning among patients. Furthermore, the oral administration of treating AD has had some drawbacks that decrease the medication adherence and efficacy of the therapy. Transdermal drugs are proposed as an alternative remedy to overcome the disadvantages of current pharmaceutical dosage options for this chronic disorder. They could have different strengths, such as offering a stable diffusion of active substance, avoiding the first pass metabolism, and reducing system adverse reactions. This article reviews the technical principles, novel techniques of transdermal delivery drug, and prospects for future development for the management of cognitive and behavioral dysfunctions in AD patients.
Trypsin inhibitors demonstrate antioxidant activities, inhibit A549 cell proliferation, and increase activities of reactive oxygen species scavenging enzymes p. 155
Tooba Naz Shamsi, Romana Parveen, Sadaf Fatima
DOI:10.4103/ijp.IJP_553_16 PMID:28706328
OBJECTIVES: Protease inhibitors are one of the most promising and investigated subjects for their role in pharmacognostical and pharmacological studies. This study aimed to investigate antineoplastic and antioxidant activity of trypsin inhibitors (TIs) isolated from three plant sources and their inhibitory role in the cell line. MATERIALS AND METHODOLOGY: TIs were obtained from different plant sources. Antineoplastic potential on adenocarcinoma human alveolar basal epithelial cell line (A549) and normal Human Embryonic Kidney (HEK) was determined using MTT assay. Activities of antioxidant enzyme, nitric oxide scavenger, superoxide dismutase, glutathione S-transferase, and glutathione peroxidase were assessed in cell lines incubated with and without TIs. The outcome was analyzed by spectrophotometer. RESULTS: TIs showed the higher cytotoxicity on A549 cells as compared to normal HEK cell line. TIs exhibited fair increase in antioxidant enzyme activity in A549 cells as compared to control. This might be one of the strategies of antineoplastic effect in cancer cells. CONCLUSIONS: This study has reported the antioxidant and antineoplastic properties of these TIs for the first time in A549 cells (to the best of our knowledge). The results show that TIs possess ability to prevent cancer and diseases caused due to oxidative stress. Therefore, we conclude that TIs can be used as supplements along with the conventional drugs for increased efficacy in the treatment of diseases such as cardiovascular disease, atherosclerosis, and cancer.
Effect of karanjin on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in Balb/c mice p. 161
Praful Prakash Patel, Naitikumar Devshankar Trivedi
OBJECTIVES: The objective of this study is to evaluate the beneficial effect of karanjin for the treatment of experimental colitis. METHODS: Colitis was induced in the Balb/c mice by rectal administration of 2% solution of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in 50% methanol. Karanjin (>98% pure) was administered in two different concentrations 100 and 200 mg/kg and sulfasalazine (100 mg/kg) as reference for 7 consecutive days to colitic mice. On the 8 day, mice were euthanized and degree of inflammation was assessed by macroscopic, microscopic, histology and biochemical estimation of myeloperoxidase (MPO), nitric oxide (NO), malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and reduced glutathione (GSH) level were measured. RESULTS: Karanjin significantly and dose dependently ameliorate the macroscopic damage, histological changes such as cellular infiltration, tissue necrosis, mucosal and submucosal damage as compared to the TNBS control group. Karanjin reduces the activity of MPO, depressed MDA, and NO level and helps in restoring the level of CAT, SOD, and GSH to normal when compared to the TNBS colitis group. CONCLUSION: Result of the present study indicates that karanjin has the potential to cure colitis induced by intracolonic administration of TNBS.
Effects of co-treatment with pioglitazone and methotrexate on experimentally induced rheumatoid arthritis in Wistar albino rats p. 168
Tanushree Roy, Indranil Banerjee, Saikat Ghosh, Ranjita Santra Dhali, Anuradha De Pati, Santanu Kumar Tripathi
OBJECTIVES: Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting the synovial joints of the body. Methotrexate (MTX) is considered as a mainstay in the management of RA. However, monotherapy with MTX in RA is often limited by potential long-term toxicity. The present study was conducted to evaluate if MTX-pioglitazone combination therapy has an add-on benefit over monotherapy with MTX or pioglitazone on disease activity in male Wistar rats in adjuvant-induced arthritis model. MATERIALS AND METHODS: Arthritis was induced by single subcutaneous injection of complete Freund's adjuvant (CFA) in thirty male Wistar albino rats. They were then divided into five equal groups, which included two control groups (arthritic and nonarthritic), pioglitazone-treated (1.35 mg/kg daily), MTX-treated (0.225 mg/kg daily), and MTX + pioglitazone-treated. The disease-modifying action of the drugs was assessed by various physiological, hematological, and biochemical parameters along with histopathological and radiological analysis of affected joints. The experimental data were statistically assessed by one-way ANOVA. RESULTS: There was a significant reduction of disease activity in the MTX monotherapy group when compared with disease control. However, pioglitazone monotherapy group failed to demonstrate any significant effect on disease activity. The MTX-pioglitazone combination group demonstrated greater suppression of disease activity as compared to MTX and pioglitazone monotherapy and disease control group (P < 0.05). CONCLUSION: The present study demonstrates that the combination therapy of MTX with pioglitazone offers better control of disease activities in RA as compared to MTX or pioglitazone monotherapy.
Bioequivalence of generic and branded amoxicillin capsules in healthy human volunteers p. 176
Priyanka Pathak, Vijaya A Pandit, Priti P Dhande
CONTEXT: The Medical Council of India urges doctors to prescribe generic drugs as far as possible. The Indian Medical Association had responded earlier saying that it requires guarantees on the quality of generic forms of drugs. Although no published scientific reports are available on the issue of therapeutic inequivalence, unconfirmed clinician accounts and newspaper reports of therapeutic inequivalence exist. AIM: This study was planned to ascertain whether bioequivalence of branded and generic amoxicillin capsule is comparable. SETTINGS AND DESIGN: An open-label, randomized, single-dose, two-treatment, two-sequence, two-period crossover oral bioequivalence study was conducted in 12 healthy, adult human subjects under fasting condition. MATERIALS AND METHODS: Serum samples, collected at 8 time points, were analyzed by a validated ultraviolet spectrophotometer method. Pharmacokinetic (PK) parameters such as area under the curve (AUC)0–t, AUC0–∞, Cmax, and Tmaxwere determined along with time above minimum inhibitory concentration (MIC). STATISTICAL ANALYSIS USED: The log-transformed PK parameters (Cmax, AUC0–t, AUC0–∞) were analyzed using a Two One-Sided Test ANOVA in SAS for each parameter. Tmaxand MIC were analyzed by Wilcoxon rank-sum test in GraphPad Prism. RESULTS: Geometric mean ratio of Cmaxfell within bioequivalence criteria. The upper and lower confidence limits of both AUC0–tand AUC0–∞geometric mean ratio fell below bioequivalence criteria. Time above MIC of generic preparation was significantly lower than that of branded version. CONCLUSIONS: The generic capsule was not bioequivalent to the branded amoxicillin capsule.
Role of Elsholtzia communis in counteracting stress by modulating expression of hspa14, C/EBP homologous protein, nuclear factor (erythroid-derived 2)-like-2 factor, Caspase-3, and brain-derived neurotrophic factor in rat hippocampus p. 182
Chandana Choudhury Barua, Pompy Patowary, Arundhati Purkayastha, Prakash Haloi, Manab Jyoti Bordoloi
OBJECTIVE: Elsholtzia communis (Collett and Hemsl.) Diels has been widely distributed and is reported for many therapeutic effects. The present study aims to investigate the antistress activity of the leaf extract and its possible molecular mechanism. MATERIALS AND METHODS: Hydroethanolic extract of leaves of E. communis (100 and 200 mg/kg, p.o.) were administered for 7 days to stress-induced male Wistar rats. The experimental animals were divided into five groups (n = 6). The mRNA/protein profile of few stress responsive chaperones (hspa14), endoplasmic reticulum stress markers (C/EBP homologous protein [CHOP]), antioxidant regulating genes (nuclear factor (erythroid-derived 2)-like-2 factor [Nrf2]), apoptotic factors (Caspase-3) in rat hippocampus were studied by polymerase chain reaction and immunoblotting. RESULTS: The stress-related genes such as hspa14, CHOP, antioxidant gene Nrf2, apoptotic gene Caspase-3 which were overexpressed in the stress control group were significantly suppressed following administration of the extract at both the doses and the standard drug Ginseng. Likewise, brain-derived neurotrophic factor which is closely related with stress, was downregulated in the stress control group, was found to be upregulated following treatment with the extract and the standard drug Ginseng. CONCLUSION: Our findings clearly indicate that E. communis was able to counteract stress. Hence, it has the potential to develop as adaptogen and also as a replacement/substitute of the popularly used drug, Ginseng or Ashwagandha, which is on the verge of extinction or becoming endemic due to overuse.
Availability of pediatric-evaluated formulations in Serbia p. 189
Bojana Božić, Sanja Stupar, Duško Stupar, Uroš Babić, Milica Bajčetić
DOI:10.4103/ijp.IJP_66_16 PMID:28706333
OBJECTIVES: The aim of this study is to analyze the availability and coverage by health insurance reimbursement of pediatric formulations labeled for children up to the age of 12 in Serbia. To provide good insight in general availability of pediatric medicines, results were compared with the World Health Organization's (WHO) "Model List of Essential Medicines for Children" and with published evidence. MATERIALS AND METHODS: Sources of information about medicines are the Summary of Product Characteristics, National Health Insurance Fund (NHIF) Drug Lists, WHO Model Lists of Essential Medicines for Children, and Serbia's official drug registry (2013). RESULTS: Out of total number of medicines in Serbia, only 49% (496) were available for children. Of all available drugs for children, 66% were with license and majority were parenteral formulation (57%), followed by drugs for local use (28%) and formulations for oral use (23%). The lowest availability of medicines was for children 0–27 days. From the total number of licensed medicines for children up to 12 years old, NHIF covers 64% of drugs. The availability of the WHO essential medicines for children in Serbia was 51%, from which 92% were licensed for pediatric use. CONCLUSIONS: Our results demonstrated the alarming lack of pediatric suitable formulations in Serbia. Significant differences in the availability of drugs suitable for children exist worldwide. From global health point of view, the differences in the access to children formulations should, therefore, be of the highest priority.
An evaluation of impact of educational interventions on the technique of use of metered-dose inhaler by patients p. 194
Avadhi Nirajkumar Purohit, PP Patel, AM Gandhi, MK Desai
OBJECTIVES: The objective of this study is to evaluate the impact of two educational interventions that are demonstration versus pictorial Leaflet in patients using metered-dose inhaler (MDI). MATERIALS AND METHODS: This interventional study was done in patients who were prescribed drugs through MDI at Tuberculosis and Chest Department. The patients were enrolled in Group A or Group B as per random number table method. The method of use of MDI was assessed using a checklist based on the technique described in the WHO Guide to good prescribing. Patients in Group A were taught the use of MDI by demonstration of the technique by the investigator. Patients in Group B were educated about the technique by a pictorial leaflet based on the technique. Patients were followed up after 15 days and assessed for correct technique for use of the MDI. RESULTS: A total 100 patients were included in the study and were allotted to Group A (47) and Group B (53). Ninety-five percent of the patients had been taught by the treating physician about the method of use of MDI. All the patients at the baseline placed the lips tightly around the mouthpiece and held the aerosol as indicated in the manufacturer's instructions while the step least followed was coughing up the sputum before inhalation. The average steps correctly followed by the patients in Group A and B at baseline were 5.17 ± 2.07 and 5.11 ± 2.04, respectively. These improved significantly to 9.19 ± 0.67 and 6.67 ± 0.63 in Group A and B, respectively, postintervention. The five essential steps of using MDI were followed by 25.53% and 26.41% patients preintervention. An improvement in the technique of use of MDI was observed in 85.11% and 49.06% patients (P = 0.003) postintervention. All the ten steps of the technique were followed by 34.04% patients from Group A and none from Group B at postintervention evaluation (P = 0.0001). CONCLUSION: The inhalation technique for the use of MDI used by the patients is inappropriate. Educational interventions such as demonstration or pictorial leaflet help ensure a better use of the MDI.
Prevalence of statin use among high-risk patients in urban and rural Vellore, Tamil Nadu: A population-based cross-sectional study p. 201
Anu Mary Oommen, Khushboo Nand, Vinod Joseph Abraham, Kuryan George, V Jacob Jose
OBJECTIVES: This study assessed statin use among diabetics and those with coronary heart disease (CHD) in Vellore, Tamil Nadu. METHODS: A cross-sectional survey was conducted in rural and urban Vellore, among 6196 participants (30–64 years), in 2010–2012. Statin use among those with known CHD and diabetes (on diabetic medication) was recorded. A randomly selected sample of rural diabetics was resurveyed in 2016 to reassess statin use. RESULTS: Among 61 with CHD, 23 (37.7%) were on statins. Statin use among 422 diabetics aged ≥40 years with low-density lipoprotein ≥70 mg/dl was 13.4% in urban and 7.6% among rural. Statin usage among rural diabetics aged ≥40 years increased from 7.7% in 2010–2012 to 16.6% in 2016. CONCLUSIONS: Statin use for CHD was below 50% although higher than the use among diabetics, indicating the need to address this low rate of usage among these high-risk groups.
Palmoplantar exfoliation due to chloroquine p. 205
Pragya Ashok Nair, Trusha Patel
Chloroquine is the drug very frequently used for the treatment of malaria. It is also used in amebiasis, rheumatoid arthritis, and various dermatological conditions. Chloroquine can cause muscle problems, loss of appetite, and diarrhea as a side effect. Cutaneous toxicity includes pruritus, hair loss, photosensitivity, and color changes. Exfoliation of skin over palms and soles is caused by chemotherapeutic drugs such as axitinib, fluorouracil, idarubicin, doxorubicin, sunitinib, sorafenib, and paclitaxel. Here, a case of a 40-year-old female is presented who developed palmoplantar exfoliation with depigmentation after taking chloroquine. Although not life-threatening, this side effect of a commonly used drug may cause anxiety and functional impairment which in turn affects the quality of life of an individual.
Antibiotic resistance: Alternative approaches p. 208
Rajneesh Kumar Gaur
Fact or fiction? What healthcare professionals need to know about pharmaceutical marketing in the European Union p. 211
Pathiyil Ravi Shankar
DOI:10.4103/ijp.IJP_718_16
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Erratum: Evaluation of cytochrome P450 2C9 activity in normal, healthy, adult Western Indian population by both phenotyping and genotyping p. 213
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April is Vulnerable Road Users Month
Advisory, Traffic & Motor vehicle incidentsBy Regina Police April 2, 2015
As the temperature rises in April, so does the number of vulnerable road users. Vulnerable road users are those on the road; like motorcyclists, cyclists and pedestrians; who don't have the added layer of a vehicle protecting them. These vulnerable users are therefore more likely to get seriously hurt or killed in a collision. "Many…
Request Information – Assault of Cab Driver
Assault, Request Assistance, Robbery, Theft & PossessionBy Regina Police April 2, 2015
The Regina Police Service is asking for help from the public in its investigation into an incident last night in which a Regina cab driver was stabbed by an unknown male suspect. At approximately 9:52 p.m. on Wednesday, April 1, 2015, police were dispatched to hospital for a report of a male who had come…
Request Information – Aggravated Assault
Assault, Firearms and Weapons related, Request AssistanceBy Regina Police April 2, 2015
The Regina Police Service is still investigating an Aggravated Assault that sent a 28 year-old male in serious condition to hospital. At approximately 4:09 a.m. on Wednesday, April 1, 2015, police were dispatched to an address in the 1500 block of College Avenue for a weapons offence. Police arrived and located a 28 year-old male…
Police Investigate Stabbing Incident
Assault, Firearms and Weapons relatedBy Regina Police March 31, 2015
The Regina Police Service is currently investigating a stabbing incident from this morning resulting in serious injuries to an adult male. Police were called to a house in the 1500 block of College Avenue this morning at about 4:15am for a report of a stabbing. Police and EMS were dispatched and EMS transported an adult…
Citizens' Police Academy Class #100
CeremonyBy Regina Police March 30, 2015
The Regina Police Service Citizens' Police Academy will be wrapping up its 100th class with a graduation ceremony on Thursday, April 2, 2015. Class #100 has 29 students enrolled, and started on January 14, 2015. Citizens' Police Academy started in Regina on March 26, 1986. The first class had 20 students in attendance, with ages…
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text:
Harm Reduction »
Dr Carl for when you get presented with junk addiction "science" or "facts"
Author Topic: Dr Carl for when you get presented with junk addiction "science" or "facts" (Read 2786 times)
skramamme (OP)
Last Login:May 25, 2019, 04:02:04 PM
Our Community Board
Edited to add;
if this would be more suitable in the harm reduction section please feel free to move
I noticed someone already posted something about Dr Hart further down the page but wanted to reiterate how essential this sort of information is in dismantling the arguments and junk science used to justify the discrimination and victimisation of drug users and addicts.
http://www.drcarlhart.com/
"Over the past 15 years, I have given thousands of doses of drugs such as crack cocaine and methamphetamine to people.
I do this, with the informed consent of the research participant, as part of my research to understand how drugs affect the brain, behavior and physiology.
Based on my studies and data from other researchers, the effects produced by crack and powder cocaine are identical; they are also predictable. As the dose is increased, so are the effects.
Methamphetamine, too, produces predictable effects.
Indeed, the effects produced by methamphetamine are identical to those produced by d-amphetamine – the main compound in the popular Attention-Deficit Hyperactive Disorder (ADHD) treatment medication, Adderall (Kirkpatrick et al., 2012). The notion that methamphetamine users have brain deficits that lead to cognitive impairments is not supported by evidence from research (Hart et al., 2012). "
See http://www.drcarlhart.com/this-is-your-brain-on-drug-education/ for more
Anyway, hope someone finds his site and TED talks interesting
« Last Edit: October 18, 2015, 10:44:58 AM by skramamme »
Of all the things I value most in life
I see my memories and feel their warmth
And know that they are good,
You know that I should
LEAP-sourced Article: "School To Prison Pipleline Facts"
Started by andrew In the Media
The Science of Drug Abuse and Addiction - National Institute on Drug Abuse
"I will not give you the gift of hating you"
Started by St. Theresa In the Media
by sk8phaze
7 Facts About Drugs That Will Make You Question Everything You Know
by 10kites
A glimpse into my bizarre world of the Sydney hardcore "G"+Meth scene ...
Started by Chip GABAergics
www.psychforums.com's "Drug Addiction" board (inc. a husband's bizarre antics)
by Z
7 Facts About Drugs and Addiction
Started by Chip Psychology and Psychiatry
The End of the Breathalyzer? [science news from that last 10 days]
Started by Chip Drug Testing & Analysis
The "F scale: test your estimate of fascist receptivity at the personality level
The Science of Drug Use: Discussion Points for Teens or Adults
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Tatum Leverette has been a member of HBCU CONNECT since May 19th, 2016. Tatum represents Fort Valley State University class of and is located in the Covington, GA area. You can connect with Tatum Leverette and other interesting members of HBCU CONNECT by signing up or logging in.


The ISA was introduced 20 years ago in April 1999 and, in that time, £8.74trn has been placed in the savings vehicle, while an estimated £30bn has been saved in income tax, according to Hargreaves Lansdown.
Commenting, Hargreaves Lansdown personal finance analyst Sarah Coles said: "With an economic Brexit slowdown and tax rises looking likely, it's never been so important to take advantage of your ISA allowances and protect your savings and investments from tax forever.
Coles added that, while ISAs have "evolved substantially for the better" with increased allowances, better tax breaks, flexibility, ISAs with government bonuses and more investment options, they are "not perfect".
"Given how the number of ISAs has expanded over the past few years, they are crying out for streamlining and simplification to help people get to grips with the benefits of ISAs without being confused into paralysis by the proliferation of choice," the personal finance analyst concluded.


mixed emotions to put this down.
down from the moderator role, which I have been discharging for all these years.
level adhering to the list guidelines which we had worked on.
All was fine, until a year now, there are some issues regarding the platform.
him regarding these issues. It seems, I have lost all contacts with him.
list can somehow reach out to him, probably we can get the list to order.
think it take the InclusivePlanet way.
Being an ardent optimist, I do hope the list shall overcome this rough patch.
taking any maintenance request from any member.
and realize the purpose for which the list was made in the first place.
doing so. It was an unpleasant task nevertheless a job which had to be done.
With this I sign off as a moderator.


From the brilliant white beaches of the Limestone coast to the world famous wineries of the Barossa Valley, South Australia is definitely a destination for those with a taste for the finer things in life. Its elegant city Adelaide is a convenient base to explore from, and due south of the city lies Kangaroo Island, a microcosm of the exotic flora and fauna of Australia and home to one of Australia's most luxurious hotels - Southern Ocean Lodge.
Any South Australia holiday will perfectly demonstrate how many varied experiences you can have in just one area of the country. Starting at the state capital of Adelaide, the arty city with a cultured vibe and a liking for the good life, good food and wine.
To escape to more peaceful and tranquil settings locals pack their cool boxes and head over on the ferry to Kangaroo Island for wildlife encounters and the chance to see not only kangaroos, but seals and dolphins and a wide variety of exotic fauna and flora.
The fine sandy beaches on this accessible island are complimented by awe-inspiring geological rock formations such as Admiral's Arch and the granite outcrop simply called the Remarkable Rocks, shaped over hundreds of millions of years by the forces of wind and water to become just one of the islands signature landmarks.
Back on the mainland, another of South Australia's state treasures is located 60 kilometres north of Adelaide: Barossa Valley, the major wine-growing region. Since the region was first settled in 1842 the vineyards have grown to international acclaim and now there are over 150 wineries. Barossa Valley is also famed for its artisan food experiences and there are many top quality restaurants for you to visit when you explore this fertile province.
Be sure to embark on wine and food tours and drop into craft shops on one of the many heritage trails that criss-cross the region. Indeed there are so many different ways of discovering South Australia; why not explore this region by balloon safari for an aerial adventure that will leave you spellbound by the beauty and vast expanse of nature laid out below.
If it's dramatic landscapes you're after then South Australia does not disappoint. The Flinders Ranges and Outback, boasting rugged mountain ranges, spectacular gorges and sheltered creeks is one of the greatest natural regions of South Australia. It is also your opportunity to become acquainted with the Aboriginal culture.
The Flinders Ranges are of immense cultural significance to the Adnyamathanha people. Here you can visit the Yourambulla Caves, Sacred Canyon and Chambers Gorge for rock art that dates back tens of thousands of years.
South Australia has many highlights offering everything from beautiful coastline to long sandy shores and cosmopolitan cities. It can take lifetime to explore and unlock its full potential but with a little perfect planning it will also make the perfect journey and a fascinating snap-shot of life Down Under.
The best advice? Eat out! If you're holidaying in South Australia, the restaurants in Adelaide, the Barossa Valley and even Kangaroo Island, have some of the best food and wine in the country.
Take a look at all the escorted tours and excursions on offer for your next trip to South Australia.
From self-catered apartments to all-inclusive luxury hotels, find the ideal accommodation for your South Australia holiday.
There are 21 itineraries to choose from below. Use the filters to refine your options.


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Dating harassment
For miss universe dating tim tebow quite
Posted on 09.03.2020 09.03.2020 by Mar
Tebow has opened up several times about his search for love. I want to have kids. I have so many things I want. No one will be happier than me when I finally find the right person. Nel-Peters, 23, was crowned Miss Universe During the Miss Universe pageant, Nel-Peters said that she wanted to teach self-defense workshops to women - an issue with which she has a personal history. While she was the reigning Miss South Africa, she was carjacked - and the attackers tried to force her into the car.
After they crossed paths at a Super Bowl party, Nel-Peters, 23, reportedly split from her longtime boyfriend in the spring, before she and Tebow, 30, became an item, according to Terez Owens.
Jul 18, � Shortly after Tim Tebow confirmed he's dating Demi-Leigh Nel-Peters, last year's Miss Universe opened up about the relationship Wednesday. Jul 11, � Tim Tebow is certainly fond of Miss Universes. Following his ill-fated romance with former pageant queen Olivia Culpo in , the Mets prospect has . Jul 11, � For the second time in his life, minor league baseball player Tim Tebow appears to be dating a Miss Universe. Tebow, who once dated Olivia Culpo, now .
The Heisman Trophy winner is also said to have gifted the beauty queen an expensive David Yurman necklace for her birthday last month.
Both Katie and Robby Tebow shared snaps of the new couple on Instagram, all posing together in group shots.
Read Next. Sonny Gray: How I'm working through these debacles.
Jul 11, � Tim Tebow appears to be dating Miss Universe Demi-Leigh fireemblemheroestips.com the New York Post pointed out, the two have not gone public with Author: The Big Lead. Jan 10, � Tim Tebow is off the market. The year-old Mets farmhand and former quarterback popped the question recently to his girlfriend, Miss Universe Demi-Leigh Nel-Peters and as Author: Desmond Bieler.
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Tim Tebow On His Surprise Fairytale Proposal To Girlfriend Demi-Leigh Nel-Peters
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Share Selection. She punched one of them in the throat and escaped. Ignite your passion.
Live your purpose. Last February, the foundation threw its fourth successful Night to Shinea worldwide prom for people with special needs. Our lives should be about bringing faith, hope and love to those needing a brighter day in their darkest hour of need.
Jul 16, � Tebow previously dated Olivia Culpo, who won Miss Universe in Tebow's NFL career was notoriously rocky, but during his collegiate years at Author: Jennifer Kline. Jul 17, � Miss Universe Demi-Leigh Nel-Peters of South Africa and baseball player Tim Tebow are dating. Multiple news reports say that Tebow made the revelation in an interview with ESPN. Jul 15, � Tim Tebow is dating Miss Universe Demi-Leigh Nel-Peters!. PEOPLE has confirmed that the year-old former NFL quarterback, who famously switched from football to Author: Steve Helling.
For now, Tebow will move slowly with Nel-Peters and see where things go. FB Tweet ellipsis More.
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3 thoughts on "Miss universe dating tim tebow"
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Tim Tebow Is Engaged To Former Miss Universe Demi-Leigh Nel-Peters - Access


Peter Han is Vice President, Chief of Staff, for Colorado School of Mines, and has advocated for higher education institutions and programs for over 26 years. In his current role, Peter provides executive leadership for a broad portfolio of university functions including government relations, marketing and communications, and strategic partnerships, and provides counsel to the President on university initiatives.
Previously, Peter served MINES as Vice President for Institutional Advancement and led a capital campaign that raised $132 million.
Peter graduated from the University of Chicago with bachelor's degree in economics, and received an MBA from the University of Colorado Executive Programs. He was active in fundraising for Polaris at Ebert Elementary School in Denver, and served on the Board of Directors for the Foothills Art Center in Golden. Peter and his wife Alenka are parents of two DSA orchestra majors.