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Abbas to Biden: Palestinian State Key to Beating ISIS
U.S. vice president met with Palestinian leader, who sent his condolences to the family of an American killed in a recent terror attack.
Jack Khoury
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Then-U.S. Vice-President Joe Biden shakes hands with Palestinian President Mahmoud Abbas in the West Bank city of Ramallah March 9, 2016 Credit: Reuters
Palestinian President Mahmoud Abbas told U.S. Vice President Joe Biden on Wednesday that a victory over ISIS and terror requires the establishment of a Palestinian State within the 1967 borders.
Biden calls for end to violence, but says Israel can't stop it 'just by physical force'
Biden urges Netanyahu to sign military aid deal with U.S. while Obama still in office
Series of terror attacks have nothing to do with ISIS - or Biden
Abbas also reportedly denounced "all forms of terrorism" after Biden criticized the Palestinians, demanding they condemn recent violence.
In a statement issued from his office, Abbas said the key to security and stability in the region is a plan that would give the Palestinians hope for a state.
Israel's continued occupation and the expansion of the settlements only moves this solution farther away and renders it ridiculous, he said in the statement.
The Palestinian news agency Ma'an reported that Abbas extended his condolences to the family of Taylor Force, an American who was killed on Tuesday during a terror attack in Jaffa.
Abbas added, however, that over the past five months more than 200 Palestinians were killed.
The agency said Biden had conveyed a message to Abbas that the United States was committed to the two-state solution.
Senior Palestinian officials said that Abbas made it clear to Biden at their meeting that any peace settlement must be based on UN resolutions. He also objected to the demand to recognize Israel as a Jewish state.
"We have no expectations of the Americans and are disappointed with Biden and the administration's statements and call to recognize Israel as a Jewish state," one official told Haaretz.

redpajama_set_name: RedPajamaCommonCrawl


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CEDAW: Singapore
Sayoni's CEDAW resource site
2017 CEDAW Report
Sayoni submitted its shadow CEDAW report to the 49th Session on 20 June 2011 (download the PDF version here)
3. Article 5: Sex roles and stereotyping
4. Article 10: Equality in Education
5. Article 11: Employment
6. Article 12: Health
7. Article 15: Equality before the Law
8. Article 16: Marriage and Family Life
10. About the Author
Growing up, girls who are perceived to be queer in Singapore face isolation or bullying at school and pressure to conform to stereotypical gender roles and expression. Information about safe sex for queer persons is excluded from sex education curricula.
Queer adolescents and teenagers, like those in other countries, are at a higher risk of depression and suicide because of social stigma and rejection. Discrimination that they experience is further perpetuated by censorship in mainstream media, resulting in a negative portrayal of their identity or orientation.
At the workplace, almost all queer women report perceiving varying degrees of discrimination. Many resort to hiding their gender identity/ sexual orientation in order to protect themselves against discrimination, harassment and blackmail. If they do experience discrimination by their company, colleagues or supervisors, there is no legal recourse. They are unable to access spousal and maternity employment benefits; and income tax benefits. Trans-women10Trans-women are also known as MTF or male-to-female. They are people assigned as male at birth but who identify as female/feminine and may or may not go through a physical transition process to become female. face especially great challenges in obtaining executive or professional positions.
Queer women have unequal access to healthcare and medical rights in a healthcare system which presumes heterosexuality in its policies and services.
Women in committed same-sex relationships cannot legally marry. This excludes them from access to social services and support for marriage and families, and importantly, corresponding rights and benefits in public housing, healthcare, employment, immigration, domestic violence, travel, taxation, parenting, separation, death and inheritance.
Our report therefore concludes that discrimination against queer women in Singapore is currently prevalent, systemic and institutionalised in social, cultural, political and economic spheres, contravening articles of CEDAW, in particular but not limited to Articles 5, 10, 11, 12, 15 and 16, as documented in this report.
Contact Sayoni
We welcome all feedback, enquiries and volunteers! Please contact us at [email protected]
Copyright © 2023 CEDAW: Singapore. All rights reserved.


Our health plans are not restricted to puppies and kittens. Once they have had their initial set of vaccines, continued annual exams and boosters are necessary to keep your pet protected. Not every pet requires the same vaccines. Your unique home environment and your pet's personal risk assessment allow our doctors to personalize a vaccination protocol specific for your pet. Excessive vaccinating or vaccinating for unnecessary diseases can be harmful to your pet. Our goal is to maximize your pet's health and quality of life in an affordable manner.
Healthy Paws savings plans for adults include many services that will help keep your pet happy and healthy, such as a comprehensive exam to ensure the proper growth and development of your pet, vaccines (or vaccine titers- to see if your pet is already protected and even needs a booster) based on a thorough Risk Assessment of your pet's environment and lifestyle, behavioral counseling, advice on nutritional issues and breed specific health counseling, appropriate preventive dental care and weight management advice, and diagnostic testing for internal parasites. Plans also provide savings on heartworm and flea preventives year round.
Our annual wellness appointments are scheduled for 30 minutes so that you have adequate time to discuss your pet's needs with the doctor and ensure that we are giving your pet the best care possible. You can also use our convenient, drop off service to leave your pet for the day while you work, shop or play - at no additional charge.
Check out our interactive chart below illustrating our most popular vaccine packages and savings plans. We also offer individual vaccines if a package is not yet needed.
Southern Hills Offers Convenient, Affordable Pet Care!


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Kostelska rakíja je tradicionalni alkoholni sadni destilat, ki ga pridelujejo na območjih občin Kočevje, Kostel in Osilnica. Pridobivajo ga iz avtohtonih vrst jabolk, hrušk in sliv ter s tradicionalno tehnologijo, ki mu dajejo posebne značilnosti, kot je npr. cvetica. Kostelsko rakíjo se pridobiva z destilacijo sadja, na preprostih pripravah z deflegmatorjem (posebnim pokrovom kotla). Le ta hlape z nizko vsebnostjo alkohola kondenzira v majhne kapljice.

Pridelava
Prideluje se jo v prostoru Regijskega parka Kočevsko-Kolpa, kjer rastejo avtohtone vrste:
 jablan (krivopecelj, bobovec, carjevič, kanadka, kosmač, beličnik, zlata parmena, voščenka, čebulnik, maškotela, pisanka,...),
 hrušk (tepka, moštanka, preška, štajerka,...),
 sliv (kostelska češplja).

Sadju se najprej določi tehnološka zrelost s Streifovim indeksom, nato pa se ga zmelje skupaj z vrelnim nastavkom. Vrenje poteka do enega meseca, potem pa se opravi prva prekuha. Tako nastane surovo žganje. Z drugo prekuho ločimo posamične sestavine.

Zunanje povezave
 Kostelska rakija (Natura 2000)

Viri in literatura

Alkoholne pijače
Občina Kočevje
Občina Kostel
Občina Osilnica

redpajama_set_name: RedPajamaWikipedia


Version 2.3 of the permanently-installed system to flush all outboard engines automatically in a sequence. After a single hose connection, and one press of a button, the system will flush one engine at a time. The system shuts down after all flushing cycles are complete.
*Due to high demand, current lead time is approximately up to 3 weeks before shipping. Orders will be fulfilled in the order they are received.


Pheu Thai will stage a special football match today with former Thai Rak Thai Party executives to celebrate the end of their time in the political wilderness, Pheu Thai spokesman Prompong Nopparit said yesterday.
Prompong said four teams would take part in games starting at Thephasadin Stadium at 4pm.
The first team will be made up of members of the current Cabinet and ex-ministers, who are former Thai Rak Thai or People Power executives.
The 111 former Thai Rak Thai executives are due to end a five-year political ban in late May.
The second team will be Pheu Thai MPs and senators invited to join in the games.
The third will be from the media and the fourth will be entertainers and artists.
The first game will be between the team of MPs and senators against the entertainers. Then, the team of Cabinet members and former ministers will play against the reporters' team.
Players will then merge into two special teams to compete against each other.
Prompong said the party was waiting for Prime Minister Yingluck Shinawatra, to see if she can kick-start the games.
Former Thai Rak Thai executives who will join the event include Chaturon Chaisaeng, Pongthep Thepkanjana, Varathep Rattanakorn. Former PM Somchai Wongsawat, who was a People Power executive, will also play.


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Q: WSO2 ESB - Adding databases through Admin Console Feature I am new to WSO2 ESB and then I've started by following the initial steps described on WSO2 ESB product documentaion page. After the first samples succesfully run, I've got myself stuck trying to exercise the Database mechanism.
According to WSO2 ESB documentation - http://docs.wso2.org/wiki/display/ESB460/Databases - Admin Console feature must be installed to add a new database. So, I've tried to add that feature to my  ESB installation by creating several repositories (http://dist.wso2.org/p2/carbon/releases/3.0.0 up to 4.0.5 and even the local version of 4.0.5 p2-repo.zip) , but after all I had no success in finding the Admin Console Feature, so no Database option for me. Even after adding the Datasources Feature, the Database option did not show up.
What am I missing here ? Is the documentation outdated ?
Thanks.

A: Otmar, That particular database provisioning feature that you are referring to as admin console feature was renamed to "rss manager". Please lookup for the feature with that name in the p2 feature repository.

redpajama_set_name: RedPajamaStackExchange


Does the 8 Hour Diet Really Work?
INTERMITTENT FASTING. Review of the 8-HR DIET.
This is my review of the 8 HR Review by Men's Health. I also discuss Intermittent fasting and my experience and results from it.


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Disposable Chopstick Demand Is Killing China's Forests As Annual Production Reaches 80 Billion
By Sara Gates
Bowl of round rice noodles with chopsticks and spoons on table in Yangshuo, China.
China's demand for disposable chopsticks has increased by nearly 30 billion in the past few years, and the need has become a burden on the country's forests.
According to Bai Guangxin, chairman of Jilin Forestry Industry Group, China produces 80 billion disposable chopsticks per year, state news agency Xinhua reports. According to a HuffPost translation, Bai estimated during a meeting at parliament on Friday that 20 million 20-year-old trees would be required to cover China's annual chopstick production.
A previous estimate from China's state forestry administration, based on statistics from 2004 to 2009, put the yearly total at 57 billion disposable chopsticks -- a far cry from Bai's current estimate. Comparatively, the production of 57 billion chopsticks accounted for the destruction of 3.8 million trees, the New York Times reported in 2011.
The consequences of China's chopstick production -- deforestation, for one -- have prompted action from some environmental groups. In 2010, Greenpeace East Asia partnered with Chinese artist Yinhai Xu to create a disposable chopstick forest in a public space to shed light on the country's staggering demand for wood to make the utensils.
Bai pointed out during the meeting Friday that the Chinese government has also begun taking action by introducing policies limiting manufacturing of disposable chopsticks.
Government actions range from a 5-percent tax levied in 2006 on disposable chopsticks, to a 2010 warning of potential government regulations for companies that fail to strictly supervise disposable chopstick production.
While China plans to increase its forest coverage by 40 million hectares before 2020, increased production of disposable chopsticks could hinder that goal.
"We should change our consumption habits and encourage people to carry their own tableware," Bai recommended on Friday.
In the U.S., Americans threw out 31 million tons of plastic -- including plastic utensils -- in 2010, making up 12.4 percent of the nation's municipal solid waste. According to the Environmental Protection Agency, only 8 percent of that plastic waste was recovered from recycling.
Top Endangered Foods
Sara Gates
Law student & former journalist
<a href="http://www.ciatnews.cgiar.org/wp-content/uploads/2011/09/Ghana_ivory_coast_climate_change_and_cocoa.pdf" target="_hplink">A report released by the International Center For Tropical Agriculture </a>warns chocolate could become a luxury item if farmers don't adapt to rising temperatures in Ghana and the Ivory Coast, where a majority of the world's cocoa is grown.


text:
Microsoft preps Project 2003
Joris Evers (IDG News Service) 05 June, 2003 07:48
Breaking its usual two-year upgrade cycle, Microsoft Corp. is getting ready to launch Project 2003, the next version of its project planning and management tool, the Redmond, Washington, vendor said Wednesday.
Project 2002, launched in June last year, is being updated this quickly so Microsoft can fit the product into its Office System 2003 release cycle, Microsoft said. Project 2003 now carries an Office label, like other Microsoft products including Visio and Real-Time Communications Server.
Project 2003 also offers several new features, including integration with Office applications, designed to simplify enterprise use of the product, said Giovanni Mezgec group product manager for Project at Microsoft.
Project Server 2003 will link with Outlook 2003 and with Windows SharePoint Services in Windows Server 2003, allowing users to access and change project information using tools they might already work with, Mezgec said.
Also, Project 2003 Server offers more possibilities to link it to other IT systems. Microsoft partners can help companies tie Project to an ERP (enterprise resource planning) system, for example, to access all kinds of data used in handling projects, Mezgec said.
Binu Alex, a business consultant in charge of the Project 2002 implementation at Fairfax, Virginia-based consulting firm American Management Systems Inc., (AMS) said he wonders if the enhancements will really allow his users to do more with Project.
"To me the enhancements sound more like more bells and whistles than that it will dramatically alter what we are doing. Although anything that makes it easier to use is good," he said. About 120 people at AMS use Project, the company does not use Outlook or SharePoint Services, he said.
Microsoft did need to come out with a new Project release and users have been asking for enhancements, according to Melinda Ballou, a senior research analyst with Meta Group Inc. of Stamford, Connecticut
"I think that the momentum behind the 2002 release, demand on part of the client base to put in additional functionality, and an increased responsiveness on the part of the Project team, combine to have them come out with this release in a more timely fashion, which is a good thing for them and the clients as well," she said.
Microsoft Project has been available as a stand-alone desktop planning tool for more than a decade. Project Server was first released with Project 2002 and has attracted about 1,000 customers. Some users are still in trial stages, while others have deployed it, according to Mezgec. Microsoft Project is a low-end alternative to planning products from vendors including Primavera Systems Inc. and Niku Corp.
Microsoft Office Project 2003 was announced at the ProjectWorld Conference in Boston on Wednesday and is planned to be available in the second half of the year. The product will be available in a stand-alone desktop edition and as the Microsoft Office Enterprise Project Management Solution, which includes Project Professional, Project Web Access and Project Server, Microsoft said.
Pricing has not been announced.
More about American Management SystemsMeta GroupMicrosoftNikuPrimavera SystemsVisio
Enhanced Service Level Agreements (eSLAs) on the nbn broadband access network


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Clinical research: Regulatory uncertainty hits drug trials in India
The Pharmaceutical Journal 12 MAR 2015By A Nair
A Nair
A Nair is a freelance journalist based in Pune, Maharashtra.
An avalanche of reforms to rules governing the conduct of clinical trials in India has led to an exodus of drug companies and research organisations.
Source: istockphoto.com
Clinical trial organisers pay volunteers in cash for attending medical check-ups
Shirin Abdul Khan was 16 years old when in 2009 she was enrolled as a volunteer in a clinical trial to study the effects of adding vitamin D to conventional treatment for patients newly diagnosed with pulmonary tuberculosis. Along with many of her school friends, she was lured by the easy money.
"It was harmless," Khan says. "We just had to sign a blank form every time the money was given. Whenever I had to go for a check-up, once a month, they would pay us 150 rupees (US$2.50). It was good money for a school student."
She decided to enrol after hearing about her aunt's treatment for cancer. Sairabano Khan was part of a clinical trial in 2008 to study the safety and efficacy of a new compound for the treatment of multiple myeloma.
Sairabano Khan received 700 rupees (US$11.00) at home each time she went for a check-up at the Deenanath Mangeshkar Hospital in Pune. This was one month's pay for someone who used to do household chores. She had to stop work because of her illness, and the trial money helped her make ends meet.
There are many such cases in India of money changing hands as volunteers enrolled in trials. However, the companies failed to seek adequate consent from participants in some trials. Sometimes the consent papers were in English, which most patients in rural areas cannot understand, and representatives didn't explain the many risks associated with the trial.
In 2013, India's Supreme Court took action after receiving complaints and public-interest litigation (PIL) petitions filed by non-government organisations (NGOs). All trials of new drugs were subsequently put on hold. However, the Indian government convinced the Supreme Court that the move was not in the interest of patients who needed new drugs. The Supreme Court acceded, but imposed a three-tier screening process for all trials. Since then, the Ministry of Health has laid down fresh rules and amended existing legislation to tighten the regulatory control of clinical trials (see 'Timeline of clinical trials in India'). But uncertainty over the new regulatory regime has led pharmaceutical companies and contract research organisations (CROs) to move their clinical trial programmes elsewhere.
Procedural violations
Since regulations in India were amended in 2005 in a bid to liberalise the conduct of global drug trials, companies have flocked there because of the genetic diversity of the population. However, trials in the country have been plagued by scandal. Government data show that more than 2,600 patients participating in clinical trials in India died between 2005 and 2012, and nearly 12,000 suffered serious adverse effects. Of these, 80 deaths and more than 500 serious adverse effects were directly attributed to the drug being trialled.
It was a 2009 US$3.6m post-licensure observational study, funded by the Bill & Melinda Gates Foundation, which finally prompted regulatory change. The study, which aimed to evaluate the cost and feasibility of introducing the human papillomavirus (HPV) vaccine into the country's universal immunisation programme, was run by the Programme for Appropriate Technology in Health (PATH), a non-profit organisation based in Seattle in the United States, the Indian Council of Medical Research (ICMR) in New Delhi, and the Indian state governments of Andhra Pradesh and Gujarat. The trial, which involved 24,777 adolescent girls, was halted by the ICMR in April 2010 following media reports of the deaths of seven participants and a memorandum from 68 human rights and women's groups to the Indian Minister of Health and Family Welfare opposing the trial's "unethical" nature[1].
The media came down hard. The government had to finally concede defeat
"The media came down hard," says Chandra M Gulhati, a healthcare activist in New Delhi and editor of the Indian medical journal Monthly Index of Medical Specialties. "The government had to finally concede defeat."
The deaths were not found to be causally associated with the vaccine. However, Vishwa Katoch, director-general of the ICMR, admitted to India's Parliamentary Standing Committee on Health and Family Welfare in April 2010 that the guidelines laid down by the drug controller general of India (DCGI) had not been adhered to during the trial. The DCGI works for the health ministry and is responsible for approving new drugs, clinical trials and medical devices, as well as monitoring the quality and efficacy of pharmaceutical products on the market.
After little action by the Indian Government, the women's health activists who had brought the case to the attention of the Indian Parliament filed a PIL petition in the Supreme Court about unethical promotion of the vaccines in the private and the public sector, violation of rules on informed consent and the need to investigate the deaths and adverse events after vaccination. Those required to respond to the petition included the DCGI, the ICMR, the states of Andhra Pradesh and Gujarat, PATH International, and the vaccine manufacturers. A second petition on the HPV vaccination project was jointly filed by two NGOs — SAMA, a resource group for women and health, and the Karnataka-based Drug Action Forum — and Delhi Science Forum. These petitions came on the back of earlier PIL petitions on clinical trials filed by NGO Swasthya Adhikar Manch, and doctor and whistleblower Anand Rai.
In a report published in August 2013, the Parliamentary Standing Committee on Health and Family Welfare said that PATH had violated laws and regulations laid down for clinical trials in India while conducting the HPV trial, and accused it of promoting the interests of HPV vaccine manufacturers, who would have reaped huge profits had the vaccine been included in the universal immunisation programme[2]. The report was also critical of the ICMR, which forms ethical guidelines for researchers, pointing out that its involvement in the study gave rise to a conflict of interest.
In a statement, PATH stressed that it strongly disagreed with the findings, conclusions and tone of the report, which it said disregarded the evidence.
Supreme Court intervention
In September 2013, India's Supreme Court stepped in, ruling that no clinical trials should be allowed for new drugs until a mechanism is put in place to monitor them.
Because of the increasing number of deaths and public concern across the country, all trials were held in abeyance
"[Because of] the increasing number of deaths and public concern across the country all trials were held in abeyance," says Gulhati, who is also a former World Health Organization consultant on drugs. "Trials were never banned completely."
The immediate consequence of the Supreme Court's actions was that the number of new clinical trials dropped dramatically. Data from the Indian Government show that the number of applications to conduct clinical trials in India fell from 480 (with 253 approved) in 2012 to 207 (with 73 approved) in 2013.
Since the Supreme Court's decision, 162 trials approved by the DCGI have been put on hold. A senior official of a multinational drug company says this has been a major setback.
Speaking at BioAsia 2015, an annual international life sciences conference held in Hyderabad, India, in early February 2015, an official from the CRO Quintiles said there were several hundred clinical trials taking place in the country before 2010 that were in complete compliance with international and local guidelines. Quintiles currently has approval for ten trials in India but commenced just one trial in 2014. Many CROs say that conducting clinical trials in India is now difficult and cumbersome, and have not gone ahead with trials despite getting government approval.
Leena Menghaney, access campaign coordinator at humanitarian organisation Médecins Sans Frontières (MSF), says that for the past two years, MSF has not had the clearance it needs to conduct operational research on HIV patients living with tuberculosis.
Gulhati insists that trials are still going on in India under the new rules, but that approvals for trials are taking much longer. "It is an ongoing exercise, since the Ministry of Health is issuing new orders to take into consideration the directives issued by the Supreme Court,'' he says.
The Supreme Court has stripped the DCGI of powers to approve clinical trials. "The Supreme Court asked for a mechanism to be put in place. There is a three-tier system now for all trials. There is a subject committee of 10-12 members for each therapeutic area, a technical committee, which has 20 members, and an apex committee,'' Gulhati explains. "Only when all the three approve the trial can the application go to the DCGI."
Gulhati says the new rules are aimed at ensuring that patients are not misled. He alleges that of 100 trials that took place before the Supreme Court stepped in, informed consent was perfunctory in at least 80. "It was not worth the paper it was written on, since most did not detail the side effects, or the compensation amount. It was just permission given by the patient to allow the company-appointed investigator to treat them."
Informed consent must now be audio and video recorded. It has become difficult for multinational drug companies to dodge accountability if trials of their patented drug lead to adverse reactions, says Gulhati.
Mary Francis, director of Jovis Clinical Research, a clinical research consulting and training company based in Mumbai, and chief executive of CRO Mascot Spincontrol, says that since the new rules were introduced, the process of registering with the DCGI and Clinical Trials Registry has become more time consuming. "All the approvals have to be in place. Some new investigators don't have proper infrastructure, or their insurance papers are not in order. If the drug is the first line of treatment in the market (a new chemical entity), it takes a longer time,'' she adds.
An official with Scientia Clinical Services, a CRO base in Pune, questions the need to have investigators and sites registered before each trial, as has been mandated by the government, and says the many 'must-haves' in the new regulations are mind-boggling.
"Sponsors do not have the power to choose any investigator or a particular site. The power to do so rests solely with the regulator," he says. "If one denotes any hanky-panky, or if the regulator is dissatisfied about the credentials, the trial could be refused."
The official adds that the registration of sites and investigators will take more time. "A simple back-of-the-envelope calculation suggests that around 12 months would be lost just for the registration process," he claims.
Global spread of clinical trials
Source: clinicaltrials.gov
Data from clinicaltrials.gov show that 1.4% of global clinical trials are currently carried out in India compared with 3.2% in China, 1.5% in the Czech Republic, 1.0% in Turkey, and 0.9% in Thailand. Half of all trials being conducted worldwide are based in North America, with the UK hosting 5.5% of trials (data retrieved on 11/03/2015).
More compensation
"The number of trials has reduced considerably because of the Supreme Court's intervention. Also there is greater compensation," Gulhati says. "Patients will now get at least four times more than they would have got before."
The health ministry is currently working on a clinical-trial policy that will incorporate quicker approvals and balanced compensation guidelines. "The baseline figure of 800,000 rupees (US$13,000) as per the formula can result in actual compensation of 400,000 rupees (US$6,500) for patients over 65 years old with a short period of expected survival and a maximum of 7.29 million rupees (US$0.1m) for young volunteers in phase 1 trials. Earlier, the compensation was 50,000 rupees (US$800) with a maximum of 300,000 rupees (US$5,000)," he says.
However, he adds that determining the cause of death is dependent on the integrity of the investigator: "There are over 30,000 investigators in India — how many are honest and how many are corrupt?" No sponsor would like to publicise unfavourable results, says Gulhati, and there is a conflict of interest because investigators are employees of the sponsor and would find it difficult to file an adverse report. "There is no independent mechanism," he adds.
Given the uncertain regime, drug companies and CROs are cutting back on clinical trials in India. The Indian Pharmaceutical Alliance (IPA), which represents leading domestic pharmaceutical companies, says that the increasing reluctance of India's drugs and devices regulator to grant approvals for new drugs, even if they are approved in developed countries, and to allow clinical trials or biostudies for export purposes, has severely hampered the industry.
The hub appears to have shifted to China, where a lot of government support has come to the aid of the industry, in terms of easier processes
Francis says that some trials have moved to other countries. "The hub appears to have shifted to China, where a lot of government support has come to the aid of the industry, in terms of easier processes. English has also been made mandatory in China, which has given a fillip to most CROs to take on work from multinationals."
She says it is easier to conduct business outside India. "CROs in Turkey, Indonesia and Malaysia are flourishing, since the regulatory norms are not so strict and approvals are given faster," she says, adding that CROs in Eastern Europe have made it cheaper to carry out clinical trials there.
"From 2010–2011, things have changed quite drastically for CROs. These regions [Eastern Europe] used to charge heavily, so many of the multinational companies moved to India, where it was 40% cheaper to conduct trials and there was a ready demographic," she explains. "Now, the margin has come down considerably."
The effects of the regulatory uncertainty are already being felt. Max India, for example, has announced that it will sell its clinical research business for US$1.5m to JSS Medical Research, a Canadian CRO. The company says the regulatory challenges have made it difficult to scale up the business.
Other Indian pharmaceutical companies, such as Biocon, Alembic, Zydus Cadila, Torrent and Lupin, have already moved trials out of the country. At Biocon, the research and development (R&D) spend is 134% higher in the second quarter of 2015 compared with the same period in 2014. The company's chairman, Kiran Mazumdar-Shaw, said at an analyst briefing that the high R&D spend is a result of ongoing global clinical trials that require large investment. For example, Biocon's global phase III trial for biosimilar trastuzumab is being conducted in Europe.
Indian CROs, such as Veeda Clinical Research and Lambda Therapeutics, have also moved out to other Asian countries, including Malaysia and Thailand. An official at Veeda says the high degree of uncertainty in India has discouraged clinical trials.
Timeline of clinical trials in India
June 2009: Registration of clinical trials in the Indian Council of Medical Research (ICMR) registry becomes mandatory.
2009: Non-profit organisation PATH along with the ICMR and two local governments start a phase 4 trial of human papillomavirus vaccine in adolescents in two Indian states.
April 2010: 68 Indian human rights and women's groups send a memorandum to the Indian Minister of Health and Family Welfare opposing what they say is the unethical nature of the PATH HPV vaccine trial and calling for it to be halted. In response, the ICMR suspends the trial.
March 2011: Twelve New Drug Advisory Committees are constituted to evaluate applications for approval of clinical trials, excluding investigational new drugs (INDs). Applications for INDs are evaluated by a separate committee.
February 2012: Indore and Pune based health activist group, Swasthya Adhikar Manch, files Public Interest Litigation seeking justice for "drug trial victims throughout nation".
January 2013: Amendments to the Drugs and Cosmetics Rules specify procedures to analyse the reports of serious adverse events occurring during clinical trials and procedures for payment of compensation in case of trial-related injury or death.
February 2013: Amendments to the Drugs and Cosmetics Rules specify various conditions for conduct of clinical trials, authority for conducting clinical trial inspections and actions in case of non-compliance. Further amendments specify requirements and guidelines for mandatory registration of ethics committees.
March 2013: The Drugs Controller General of India (DCGI) constitutes an expert committee to examine reports of deaths in clinical trials.
July 2013: The Ranjit Roy Chaudhury panel — established to advise on policy guidelines for approval of new drugs, clinical trials and banning of drugs — publishes a report suggesting major changes, including that clinical trials should be held only at centres that are accredited for the purpose, and that the existing 12 drug advisory committees should be replaced by a single broad expertise-based Technical Review Committee to ensure speedy clearance of applications.
July 2013: The US National Institutes of Health announces it is suspending 40 clinical trials in India because of the uncertainties posed by the new requirements.
August 2013: Parliamentary Standing Committee on Health and Family Welfare publishes report criticising PATH, the Indian Council of Medical Research and the DCGI over conduct of the HPV vaccine trial.
August 2013: Drugs and Cosmetics (Amendment) Bill 2013 introduced in Parliament, which contains penal provisions for violations of clinical trial procedures, and provisions for payment of compensation and ethics committees.
August 2013: The DCGI makes it mandatory for the sponsor or his representatives to furnish the details of the contract between the sponsor and the investigator with regard to financial support, fees, honorarium, and payments in kind to be paid to the investigator.
September 2013: India's Supreme Court suspends all clinical trials of new drugs in the country.
September 2013: Contract research organisation Quintiles closes its research centre in Hyderabad, a joint venture with Apollo Hospitals Enterprise.
November 2013: The DCGI issues a directive that an audiovisual recording of the process of obtaining written informed consent is required for each trial subject.
January 2015: The health ministry proposes pre-submission meetings in a bid to enable technical deliberations between stakeholders and the drug regulator before clinical trial applications are submitted.
In January 2015, in response to Indian prime minister Narendra Modi's plan to make it easier to do business in India, the health ministry proposed pre-submission meetings in a bid to enable technical deliberations between stakeholders and the drug regulator. The meetings will take place before drug companies make a formal application for clinical trials. The move is expected to enhance efficiency in the sector, given its muted growth over the past two years, and increase transparency, predictability and accountability.
For some time, drug companies have been asking for an opportunity to carry out technical deliberations with the regulator and experts before submitting an application to conduct a clinical trial. A health ministry official says it would at least ensure that a discussion takes place about the regulatory pathway, and that companies would be able to make their applications in a more systematic manner, saving time and resources for both the drug company and the regulator.
But Gulhati criticises this move, which was one of the recommendations of Ranjit Roy Chaudhury's expert committee formulated by the government in 2013 to advise on matters related to policy and guidelines for the approval of new drugs and clinical trials[3]. Gulhati says the committee is "highly pro-industry (pro-clinical trials) and anti-patient". Speaking about a major conflict of interest, he says: "Ranjit Roy Chaudhury is employed at the Apollo Hospital heading clinical research. The hospital is one of the biggest private-sector clinical site management organisations. How can he review the situation and file a report aimed at helping draft the new rules?"
Francis says the regulation of clinical trials in India is uncertain compared with other countries. "Comparatively, it is very certain abroad, since everything is on the website, the timeline and the procedure. Here [in India], nothing is clear."
To counter the many loopholes that still exist in India, Francis suggests that more experienced people are needed in CROs. "Training needs to be conducted so that people can understand the legal aspects, and understand how approvals are given, the regulatory monitoring, as well as the ramifications," she says.
However, some doctors say that clinical research in India is of a high standard and that deaths during clinical trials are to be expected. Parag Shah, who heads the male infertility clinic at Nowrosjee Wadia Hospital in Parel, Mumbai, says: "Unfortunately, the good that has come of clinical research for several thousands of patients in India is often overlooked.''
He added that the percentage death per population, and not absolute numbers, should be an important consideration.
Francis agrees: "We cannot say that [deaths in clinical trials] do not happen in other countries. Deaths due to clinical trials happen everywhere. One has to see it in perspective."
She adds: "A few rotten apples here, though, and everyone is crucified. Many CROs are actually doing genuine work. The few who disregard the norms get the spotlight."
[1]Sama: Resource Group for Women and Health. Memorandum to the Health Minister on World Health Day opposing HPV vaccinations. April 2010.
[2]Department of Health Research, Ministry of Health and Family Welfare. Seventy-second report on alleged irregularities in the conduct of studies using Human Papillomavirus (HPV) vaccine by PATH in India. August 2013.
[3]Report of Professor Ranjit Roy Chaudhury expert committee to formulate policy and guidelines for approval of new drugs, clinical trials and banning of drugs. July 2013.
Citation: The Pharmaceutical Journal, 14 March 2015, Vol 294, No 7853, online | DOI: 10.1211/PJ.2015.20068063
prasanth puvvula3 APR 2015 14:46
As rightly said by the doctor there are n numerous patients who are benefited due to clinical trials than deaths. Previously i was working for one of the clinical trial organization. During that days there used to be a trial for cancer patients. The pharmaceutical company along with clinical trial drug used to give co medication (tratzumab) as a free of cost and its actual MRP is nearly 1.5 lakh per injection. this is mainly to save patient incase clinical trial drug doesnt work. In this way i had seen many trials where patients are very much taken care. Due to some one misunderstanding whole clinical trial industry had de grown many like me had lost their jobs.
Further sir in India no government official or other industry doesnt know what is clinical trials and how important they are. If governemnet and official bodies doesnt take serious step and let industry flourish there is a danger of importing life saving drugs from other countries which would cost our patients 30 to 40 times higher than the cost available in India. I hope that days come soon.
Swati Kiran28 JUL 2016 3:27
I am not from medical field, but I know that neither India government, not media and NGOs in India are aware of importance of clinical trial. People benefitted more than those get negative impact. But as usual in India everything works on incomplete knowledge. My Bro in low in fighting with cancer and I tried to see if there is any clinical trial available as he is already in last stage. We found that only one medicine is left which cost around 12 lakhs. But after reading this not sure if he will have time to go through the process.
Pharmaceutical Toxicology
Explains the methodology and requirements of pre-clinical safety assessments of new medicines. Includes registration requirements and pharmacovigilance.
A practical guide to the drug reactions that affect particular organ systems, and the management of these reactions.
English Delftware Drug Jars
This beautiful book illustrates the art and history of the collection of English delftware drug jars in the Museum of the Royal Pharmaceutical Society of Great Britain.
Supplementary images
PDF , Size 2.74 MB
India and China spark concerns for UK drug supplies
Half of all safety warnings issued to drug manufacturers in India and China
China will accept data from overseas clinical trials to hasten drug approvals
Clinical trials and tribulations
Medicines/Drugs AdministratorTooting
Educational organisations
International and intergovernmental organisations
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Picking an End Point for the Revolution 0
How is it, that the French and American Revolutions, so close in time and goals, had such different outcomes? One answer is that the American Revolution built on the foundation of English legislative traditions whereas the French had no such traditions (at the time of the revolution it had been 175 years since the last time the Estates General had been called). Which is to say the American Revolution modified the existing system, while the French Revolution was an attempt to completely replace the old system. This gave the American Revolution an obvious end point, which the French Revolution lacked.
Liberalism vs. Critical Race Theory (A Distressing Lack of Pragmatism) 0
Increasingly liberalism and the values associated with it have been judged inadequate to the task of rectifying racial inequalities. But the question is, what are the alternatives? One that has been mentioned is Critical Race Theory (CRT). In an article from The Economist these two approaches are pitted against one another. And despite the article's attempt to be balanced it seems clear that most people who advocate for CRT as some kind of alternative have never really grappled with the practical considerations of abandoning liberalism, an ideology that despite its failings has provided the underpinning for centuries of progress.
Traffic Lights and Modern Epistemology 0
In which I present the parable of the traffic light, and a deep discussion of the various epistemologies at play in the world today including conflict vs. mistake theory, on which I spend quite a bit of time. Each of these frameworks has different consequences and benefits, but I contend that right now, no framework is dominant, and it's possible that having numerous frameworks is even worse than having a bad one.
Books I Finished in June 0
The Accidental Superpower: The Next Generation of American Preeminence and the Coming Global Disorder By: Peter Zeihan
The Good Soldier Švejk By: Jaroslav Hasek
The Diaries of Adam and Eve By: Mark Twain
White Fragility: Why It's So Hard for White People to Talk About Racism By: Robin DiAngelo
Guns of August By: Barbara W. Tuchman
Euripides III: Heracles, The Trojan Women, Iphigenia among the Taurians, Ion (The Complete Greek Tragedies) By: Euripides
Acid Test: LSD vs. LDS By: Christopher Kimball Bigelow
The Lost 116 Pages: Reconstructing the Book of Mormon's Missing Stories By: Don Bradley
Things Are More Complicated Than You Think (BLM) 0
I decide to offer an opinion on the current Black Lives Matter protests. I understand that there are a lot of opinions being offered on the subject, and it's entirely reasonable to assume that mine is not necessary nor welcome, but I hope despite that to add something to the conversation. In particular I think trying to combine combatting police brutality with eliminating all racism might make the first and arguably more important task, harder to accomplish.


A frontrunner appears to have emerged in the crowded battle to replace Ryan Finley as NC State's starting quarterback next season. But it was a young runner that stole the show at the Wolfpack's annual Kay Yow Memorial spring football game Saturday.
True freshman Zonovan Knight rushed for 139 yards on 17 carries, including an electrifying 73-yard touchdown burst, to make a strong case for playing time once State opens its 2019 season against East Carolina on Aug. 31.
As for the quarterback competition, redshirt sophomore Matthew McKay moved to the top of the depth chart heading into the summer after a strong performance that earned praise from coach Dave Doeren — whose team was one of three in the state to wrap up spring practice with an intrasquad scrimmage last weekend.
"He's comfortable, that's the easiest thing to see," Doeren said of the only quarterback on his roster that has taken a snap in an actual college game. The 6-foot-4, 210-pound Raleigh native saw mop-up duty in five games last season.
McKay completed 14 of his 24 passes for 182 yards on Saturday while leading his team on two scoring drives.
The first ended with a 7-yard touchdown run by the versatile quarterback, set up by a 40-yard completion to C.J. Riley, State's most experienced returning receiver. The second resulted in a 14-yard scoring strike to tight end Cary Angeline.
Redshirt freshman Devin Leary also led two scoring drives while going 12 of 23 for 104 yards and JUCO transfer Bailey Hockman was 12 for 23 with 135. Both threw touchdown passes. Micah Leon and Ty Evans also played, but only in a limited role.
How seriously each is able to contend for playing time in the fall will depend on the work and improvement they make during offseason workouts. Then again, as Doeren pointed out, the same can be said for virtually everyone on the roster as the Wolfpack looks to fill several gaping holes on both sides of the ball.
Among those getting those 15 practices worth of work are several incoming freshmen that enrolled early.
Of them, 320-pound defensive lineman Joshua Harris from Roxboro had one of the most impressive performances with seven tackles, including one for a loss. Cornerback Shyheim Battle also had seven tackles and a TFL for the defense.
Offensively, the breakout star was Knight, a 6-foot, 190-pound graduate of Southern Nash High School who evoked comparisons to former Wolfpack star and current Indianapolis Colt Nyheim Hines.
The Deacons were much better on offense than defense last season, and if Saturday's Gold-Black Game is any indication, things haven't changed much. With experienced quarterbacks Sam Hartman and Jamie Newman both playing well, Wake's offense defeated its defense 55-45 under a specialized scoring system instituted by coach Dave Clawson.
The offense was able to score points by gaining a first down or executing a play of 25 or more yards along with the standard points for a touchdown, extra point and field goal. The defense accumulated points for each turnover, drive stop, forced fumble and stopping a drive inside the 40-yard line.
Newman, who finished the year as the starter, completed 15 of 18 passes for 254 yards and two touchdowns while Hartman, the starter before suffering a season-ending injury, was 8 of 11 for 47 yards. Newman was responsible for a handful of big plays — a 72-yard touchdown pass to redshirt freshman A.T. Perry, a 45-yard pass to Steve Claude and a 29-yard strike to Sage Surratt.
The defense stopped eight drives and earned six points for a Kenneth Dicks III interception. Linebackers Chase Monroe and Ja'Cquez Williams tied for the team lead with seven tackles each.
Redshirt senior quarterback Quentin Harris, the heir apparent to departed starter Daniel Jones, rushed for two touchdowns and threw for another to highlight the Blue Devils' annual Spring Showcases on Friday.
Junior running back Brittain Brown was the top rusher in the 65-play scrimmage with 51 yards and a touchdown on eight carries. Sophomore wide receiver Jake Bobo was the leading receiver with five catches for 31 yards, including an 8-yard score.
Defensively, junior defensive end Victor Dimukeje recorded two tackles for loss and a pass breakup rising redshirt freshman Jeremiah Lewis intercepted a pass for the only turnover of the game.


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Quality And Affordability - It Must Be: Newhall
Linden Homes' new be:Newhall development in Harlow, Essex, is turning plenty of heads, thanks to its countryside setting, transport links and, significantly, the striking cutting-edge design of the new homes.
In March alone, around a dozen buyers have moved into their new homes at the development, many of them first time buyers eager to capitalise on the stamp duty holiday before it ended on March 24. The rush has left the development close to selling out, with just 8 homes now available for purchase.
Ebun Ojemuyiwa and her young family purchased their new three-bedroom courtyard house on the auspicious February 29, and have already moved in and begun enjoying their own home.
"Having rented in Newhall for over a year, we loved it here so much and decided to buy," Mrs Ojemuyiwa said.
While determined to purchase a brand new property in which to raise their four-month old son, the Ojemuyiwas were concerned about raising enough money for a deposit. However, help was at hand in the form of Linden Homes' exclusive shared equity scheme, Easy Start.
"Without it, we would have found it really difficult to save the required deposit," said Mrs Ojemuyiwa.
Gareth Jacob, sales and marketing director at Linden Homes Eastern, said: "We have been overwhelmed with the interest young families are taking in be: Newhall. The development offers a range of new homes to suit everyone's lifestyle, with a seamless mix of one and two-bedroom apartments, two and three-bedroom courtyard homes as well as three and four-bedroom villas."
He added: "All new homes are built to high specification with an edgy contemporary design by award-winning architect, Alison Brooks Architects. Each home includes integrated kitchen appliances, quality fittings and an energy efficient design to reduce ongoing utility bills."
Surrounded by a cluster of quaint old villages, historic Old Harlow and sprawling English parkland, be: Newhall offers a refreshingly rural environment for healthy family living, while still being connected to all the modern conveniences.
Harlow's vibrant retail and commercial centre is just a stone's throw away, as are the M11 and M25. Trains from Harlow station can take you to London's Liverpool Street in just 30 minutes.
For more information, call 01279 443 183.
For further information, contact Tracy Mannion or Naomi Wellman at Remarkable Public Relations on 01962 893 893.


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"I'm Alive Because People Care, Because People Donate Blood"
Armed Services Blood Program
In April 2012, a "normal day at work turned ugly" for Army Staff Sgt. Travis Mills. He and members of his paratrooper battalion in the 82nd Airborne Division were on routine patrol in Afghanistan when an improvised explosive device went off.
He remembers regaining consciousness a few seconds later and hearing his medic call out for help to place tourniquets on his legs and arms.
"I knew I was hit," he said.
"I lifted my left arm and saw it was kind of tattered up pretty good."
When he saw his hand, he knew it wasn't good. He wondered if he would ever see his baby girl again.
Mills lost a lot of blood that day. Without a massive infusion of new blood, he said, he probably would not have made it home.
"I'm alive because people care, because people donate blood," Mills said. "And without the blood given to the Armed Services Blood Program, I would not be able to stand here and tell you about how important it is."
Mills, now 35 and a father of two, lives in Maine. He is one of only five quadruple amputees to survive injuries from the wars in Iraq and Afghanistan.
'Fearless in a gun fight'
"My job was the military," said Mills. "I loved it. Working with soldiers every day, doing my job was the greatest for me."
He was on his third deployment. And coming home to his wife and little girl completed his dream life.
"I had a really good life mapped out," he said. "I was really doing well."
Mills' father, Dennis, said military service was what his son was meant to do. He recalls Travis as an energetic, motivated, active, and friendly kid growing up in Vassar, Michigan.
At 6 foot 3 inches tall, Mills was strong and excelled in sports. He was goofy and loved to tease his younger brother, and he always stuck up for the underdogs, Dennis said.
Soon after starting community college, he realized his heart was somewhere else. He enlisted in the Army, never looking back.
"You could see the joy in his face," his father recalled.
He excelled in the Army.
"Travis' leadership ability is like the guys that you see in movies, that people don't think really exist," said Army Sgt. 1st Class Josh Buck, Mills' friend, teammate, and brother-in-law.
"He's the guy that when you're getting shot at, you would love him next to you no matter what, because he's fearless in a gun fight."
Life-saving Blood
Army Sgt. First Class Alexander Voyce, one of the medics in Mills' unit who treated him at the scene of the blast, recalled seeing him after the injuries.
"It was really amazing seeing someone who had just lost all four limbs in such high spirits," Voyce said. "Knowing him from before, that's just his demeanor, that was just him."
Immediately after Mills' injury, medics placed tourniquets around his limbs. They reassured him that he would be okay.
"Shut up, I know," Mills responded at the time.
At a hospital in Kandahar, Mills needed blood – lots of it.
The IED blast had injured him so severely that doctors amputated portions of both of his arms and legs at the hospital.
"They used over 400 units of blood, which, at the time, was the most blood ever given," Mills said. "The blood bank at the hospital in Kandahar ran out of blood that day, and people had to rush to donate positive and universal blood to keep me alive."
The blood went straight from donors' veins to his.
In order for a patient to safely and effectively receive a blood transfusion, the blood type must either be a direct match to the patient's specific blood type, or it must be "O negative" blood, which is a blood type that is considered "universal" because it can be safely administered to anyone regardless of their specific blood type.
Never Give Up. Never Quit.
Mills set a goal for himself and his care team at Walter Reed National Military Medical Center in Bethesda, Maryland to leave the hospital within ten months.
"If I give up, I'm giving up on more than just myself," he said. "I'd be giving up on my family."
And he wouldn't do that. He needed to go take care of his wife and daughter.
"[Kelsey] and Chloe know that I'm gonna be fine, that they got nothing to worry about," said Mills. "Every day is a challenge, but it's not a challenge you can't overcome."
Mills' father recalled getting his son back. "Travis came back as Travis so quick, that he tormented me, we tormented each other just like we used to before he left," his dad said.
"I forget that he doesn't have arms and legs, because he does so well," Mills' mother, Cheri, said.
"He's still the same person and he can still laugh about life."
Within five months, as Mills got used to his prosthetic legs, he completed a five-kilometer run in New York City.
"Travis was meant to lead and help people," said Army Spc. Brandon Fessey, who was also with him during the blast. "He faces obstacles, and he doesn't let anything stop him."
In 2013, Mills founded a nonprofit organization to benefit and assist wounded and injured vets and their families. He also speaks throughout the country encouraging others to persevere through life's unexpected challenges and hold on to the motto: Never give up. Never quit.
He often speaks about the critical role that the military's blood program played in saving his life.
"I hope you will donate your blood, give back to the community, and make sure that you can keep people alive and going forward in life," he said. "Your donation of blood does matter."
How Blood Saved my Life: Travis Mills' Story
DVIDS video "I'm Alive Because People Care, Because People Donate Blood"
USU Students Dedication Leads to Mission Critical Lifesaving Blood Drives
Blood provides life-extending properties. No one knows this like U.S. Air Force 2nd Lt. Adam Stainiger does. Find out how his own mother's health journey prompted Stainiger's dedication hosting blood drives to help other service members and their families.
Uniformed Services University of the Health Sciences | Armed Services Blood Program
Blood Recipient 'Keeps On' Telling Others About the Impact Donors Make
Vanessa Aguilar is the ASBP blood donor recruiter at U.S. Navy Medicine Readiness and Training Command Guam Blood Donor Center (US NMRTCG BDC).
Chicago area Army Reserve Soldiers donate blood to combat supply shortage
Earlier this Spring, the 85th U.S. Army Reserve Support Command hosted an Armed Services Blood Program (ASBP) blood drive at the COL Paul G. Schulstad United States Army Reserve Center in Arlington Heights, Illinois.
An Appreciation for Every Drop at Naval Hospital Bremerton
ASBBC-PNW recognized NHB Jan. 24, 2022, for being instrumental in organizing, promoting and holding blood drives, especially during the time COVID shut down collection efforts during 2020 and continued to effect donation attempts during 2021.
Blood Donations Are Mission Critical 365 Days a Year
Blood donations are more than important—they are mission essential.
Navy Corpsmen Help Keep Life-Saving Blood Products Flowing
Blood products collected are distributed world-wide to provide support from deployed troops overseas to veterans and their families at home.
Blood donor center opens at new location
The Fort Gordon community and Armed Services Blood Program celebrated the reopening of Kendrick Memorial Blood Center with a ribbon cutting ceremony Oct. 15. KMBC is part of the ASBP, the military's official provider of blood products for service members and their families in both peace and war.
Retired colonel Recognized with the ASBP Lifetime Achievement Award
The Armed Services Blood Program named Retired Army Col. Francisco "Frank" J. Rentas as the recipient of the 2021 ASBP Lifetime Achievement Award.


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This house is located in the Winton Hills neighborhood near Spring Grove Village. This location provides access to I-75 and I-74 and is also close to the neighborhoods of Clifton and Northside. The house has a spaceous yard and is near multiple parks.


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Ant-Man 3 Would Explore More of the Quantum Realm
by Ana Dumaraog
– on Aug 13, 2018
Ant-Man 3 will further explore the Quantum Realm, according to Ant-Man and the Wasp producer, Stephen Broussard. Marvel Studios closed out their year by going small (both literally and figuratively) with the fan-favorite shrinking hero, Scott Lang, returning for his second standalone adventure. This time, however, he brings a new and more capable partner in Hope van Dyne's iteration of the Wasp. With the help of Hank Pym, the three rescued Janet van Dyne from the Quantum Realm where she was trapped for three decades. At the end of the film, it was Scott who was stranded in the microverse after Thanos' snap in Avengers: Infinity War also dusted off the Pyms.
Introduced in 2015's Ant-Man as "a reality where all concepts of time and space become irrelevant as you shrink for all eternity," fans saw a short glimpse of the alternate dimension again in 2016's Doctor Strange, establishing that it can also be accessed using the sorcerers' sling ring. And while Ant-Man & the Wasp finally visited the unexplored pocket of the MCU with the use of the Quantum Tunnel, it feels like the sequel created more mystery surrounding the Quantum Realm rather than answering already pressing questions. According to Broussard, this is by design as people can expect to learn more about it in Ant-Man 3.
Related: Ant-Man & The Wasp Was (Barely) A Box Office Success
Speaking on the Empire Film Podcast, Broussard teased about Ant-Man 3's eventual return to the Quantum Realm with the hopes of further exploring the alternate universe. Marvel Studios' boss Kevin Feige previously shared that there are several Easter eggs in the Quantum Realm providing clues to the future of the MCU. Meaning one way or another, the Quantum Realm will be an important part of the franchise moving forward.
"I think there's more to do there. At this point of the process with the first Ant-Man, based on a glimmer of what you saw if you froze your DVD at the right place, we had the idea of 'What if part two was about finding Janet?' And it was an inkling of an idea. Nothing's been announced, I'm not coyly sitting on any announcement. There really is no plans for the next one, but you can't help but talk as filmmakers and creative people about where you would go next if you ever got the opportunity."
"And we talk a lot about the Quantum Realm and there would be perhaps more opportunity to go down there. Maybe there's more down there than we realized. Clearly, Janet's been up to something and has different clothes on and some weapons. Where did those come from? And similarly, if you look at the right moment and freeze the DVD in a certain place, maybe you'll see something else as well that could tip a hat to where the story could go."
Despite not being confirmed yet, it's safe to say that Marvel Studios has plans for a third Ant-Man film, especially since the sequel seems to be setting up a lot of things, including what looked like a tiny civilization spotted in the Quantum Realm. While the movie franchise doesn't perform at the box office the same way as their other character-centric subseries, it's not losing them any money either. Thus far, Ant-Man and the Wasp has already raked in $448 million, around $71 million short from the first movie's $519 million total haul. But with the sequel still awaiting release in China (where MCU films tend to do well) and Japan, as well as a few other countries, it's expected to push past its predecessor's earnings.
While fans wait for Ant-Man 3, the Quantum Realm is also expected to play a major part in next year's Captain Marvel. It's still unclear how the alternate dimension fits in the narrative of the Brie Larson-starrer, but it may have something to do with the popular theory that it might actually be an important element in Earth's Mightiest Heroes' attempt to take down Thanos in Avengers 4.
More: What Ant-Man & the Wasp's End-Credits Scenes Reveal About Avengers 4
Source: Empire Film Podcast
Tags: ant-man 3
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The World's Strongest Man: 2018 Philippines
Soffe Retail Store Branding & Advertisements
Soffe Spring 2018 Product Catalog
Bear Grylls Survival Challenge
Youth Speak Website
Pokemon 2014 Licensing Exhibit & World Championship
100th Rose Bowl Game & 2014 BCS National Championship
34th America's Cup – San Francisco 2013
FX "The Americans" Submarine
Magic The Gathering – 2013 PAX Exhibit Booth
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Walter Foster – learn to draw mobile application
Long Beach Film Office – Advertising Campaign
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Philip K. Dick book jackets
The San Diego Union Tribune Newspaper Redesign
Concepts, explorations & exercises
Non-traditional advertising campaign for the Long Beach Film Office. In film and television, Long Beach has stood in for a myriad of locations – from Chicago to Miami to the vast reaches out outer space; sometimes it has even played itself. This campaign leverages the many faces that the city of Long Beach has put on in the past, and references just a few of the many productions that Long Beach has played host to. Running with the theme of Long Beach being a stand in for far-off locales, we devised a non-traditional campaign that sought to bring this capability of Long Beach to the eyes of filmmakers in the Los Angeles area. Perhaps a film or television production wants a location that looks like the harbor areas of Miami, or the suburbs of Chicago, or perhaps even wanted to use the industrial nature of the Long Beach shipyards themselves – this campaign brings that awareness to these key entertainment figures. We chose three major (and memorable) productions in which Long Beach has played a part – the TV crime drama CSI: Miami, John Hughes's 1986 production Ferris Bueller's Day Off starring Matthew Broderick, and the action packed thriller Gone in 60 Seconds starring Nicholas Cage – all of which have had major portions filmed in Long Beach. Working together with the Tribune Company, which owns many major newspapers across the country, we've created three fictitious newspaper front pages. Each front page represents the geographic area of the aforementioned film and television productions, and made them in the style of a Tribune Company publication: the South Florida Sun-Sentinel (CSI: Miami), the Chicago Tribune (Ferris Buller's Day Off), and our own Los Angeles Times (Gone in 60 Seconds). The news stories on the top half these fake front pages relate directly to a pivotal theme or event in each production, while the bottom half is a reveal for the Long Beach Film Office. These fictitious newspapers would run for one day in the greater Los Angeles area, with one of the three front pages going to a separate region. Credit: Jack Curry and Julian Jones-Pittman.


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Colorado Man in Jail Suspected of Sexually Assaulting Seven Kids + Counting
Maxx Updated: December 20, 2021
Arapahoe County Sheriff's Office/Getty Images
A man who is currently being held in a Colorado jail on over 40 charges for sexually assaulting seven children is now being further investigated as authorities say they believe there could have been more victims than previously accounted for.
Arapahoe County Sheriff's Office
According to a news release from the Arapahoe County Sheriff's Office, 51-year-old Allan Richard Long was arrested back in September and faces a total of 41 felony counts in relation to the sexual abuse of children.
Long is currently in the Arapahoe County Detention Facility with a $1 million bond, as per reports.
The seven victims accounted for in this case range in age from 4 to 16 - but now, investigators believe there very well could have been more victims tied to Long.
Long has ties to Colorado, Kansas, Wyoming, and Montana, the news release says. Investigators now believe that Allan Richard Long could have committed multiple sexual assault crimes in the states mentioned above, and possibly others - as he reportedly had access to families through his work.
Prior to his arrest, Long was employed as a volunteer firefighter, tow truck driver, truck dispatcher, as well as, an over-the-road truck driver.
As per the news release, investigators say their records of child sexual assault cases affiliated with Long date all the way back to 2001, but his crimes could've even started before that.
If you or anyone you know believes you may have been a victim of Allan Richard Long, or if you have any information about him, you are asked to contact Investigator Andrew Fehringer with the Arapahoe County Sheriff's Office at 720-874-4065 or afehringer@arapahoegov.com.
12 Notorious Criminals Locked Up in Colorado's SuperMax Prison
Colorado is home to one of the most notorious prisons in the county which holds some of the most notorious prisoners.
Take a Peek Inside Colorado's Notorious SuperMax Prison
Colorado's SuperMax Prison, also known as ADX, holds some of the most notorious criminals alive.
Source: Colorado Man in Jail Suspected of Sexually Assaulting Seven Kids + Counting
Filed Under: Colorado
Categories: Colorado Crime, Colorado News


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Vinyl mastering is a form of analog mastering whereby the album is prepared for optimal playback on a vinyl record. A mastered song for a CD and digital release is quite different from the same song that is mastered for vinyl. The overall equalization and balance is similar but dynamic range and optimization can be quite different.
With vinyl mastering we adhere to the standards set forth by the Recording Industry Association of America (RIAA). The RIAA dictates the specification for the recording and the playback of vinyl records (phonographs). Generally speaking, recordings are boosted in the high end and reduced in the low end for the recording and the reverse happens during playback. That is, the high-end is reduced and the low-end is boosted. The purpose of this process is to enhance playback, boost playback times, and reduce groove damage that can otherwise occur during playback.
RIAA equalization is not a low-pass filter. It has equalization points in three places; 2100 Hz, 500 Hz and 50 Hz . Implementing this characteristic is not especially difficult, but is more involved than a standard EQ filter. Nearly all hi-fi preamplifiers and receivers had a built-in phono preamplifier with the RIAA characteristic but not necessarily included in modern designs. Add-on phono preamplifiers with the RIAA equalization curve are available; these adapt a to an unbalanced ?10 dB consumer line level RCA input. Some modern turntables feature built-in RIAA standard pre-amplifiers. Special preamplifiers are also available for the various equalization curves used on pre-1954 records.
See RIAA Equalization.
Vinyl mastering is an additional cost of $20 per song. The files are delivered as .WAV or .AIFF, whichever the cutting plant requires. In some cases DDP files are required.


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Q: Using Instance Variables in Class Methods - Ruby I have a class something like below, and I used instance variables (array) to avoid using lots of method parameters.
It works as I expected but is that a good practice?
Actually I wouldn't expect that worked, but I guess class methods are not working as static methods in other languages.
class DummyClass
  def self.dummy_method1
    @arr = []
    # Play with that array
  end

  def self.dummy_method2
    # use @arr for something else
  end
end

A: The reason instance variables work on classes in Ruby is that Ruby classes are instances themselves (instances of class Class). Try it for yourself by inspecting DummyClass.class. There are no "static methods" in the C# sense in Ruby because every method is defined on (or inherited into) some instance and invoked on some instance. Accordingly, they can access whatever instance variables happen to be available on the callee.
Since DummyClass is an instance, it can have its own instance variables just fine. You can even access those instance variables so long as you have a reference to the class (which should be always because class names are constants). At any point, you would be able to call ::DummyClass.instance_variable_get(:@arr) and get the current value of that instance variable.
As for whether it's a good thing to do, it depends on the methods.
If @arr is logically the "state" of the instance/class DummyClass, then store it in instance variable. If @arr is only being used in dummy_method2 as an operational shortcut, then pass it as an argument. To give an example where the instance variable approach is used, consider ActiveRecord in Rails. It allows you to do this:
u = User.new
u.name = "foobar"
u.save

Here, the name that has been assigned to the user is data that is legitimately on the user. If, before the #save call, one were to ask "what is the name of the user at this point", you would answer "foobar". If you dig far enough into the internals (you'll dig very far and into a lot of metaprogramming, you'll find that they use instance variables for exactly this).
The example I've used contains two separate public invocations. To see a case where instance variables are still used despite only one call being made, look at the ActiveRecord implementation of #update_attributes. The method body is simply load(attributes, false) && save. Why does #save not get passed any arguments (like the new name) even though it is going to be in the body of save where something like UPDATE users SET name='foobar' WHERE id=1;? It's because stuff like the name is information that belongs on the instance.
Conversely, we can look at a case where instance variables would make no sense to use. Look at the implementation of #link_to_if, a method that accepts a boolean-ish argument (usually an expression in the source code) alongside arguments that are ordinarily accepted by #link_to such as the URL to link to. When the boolean condition is truthy, it needs to pass the rest of the arguments to #link_to and invoke it. It wouldn't make much sense to assign instance variables here because you would not say that the invoking context here (the renderer) contains that information in the instance. The renderer itself does not have a "URL to link to", and consequently, it should not be buried in an instance variable.

A: Those are class instance variables and are a perfectly legitimate things in ruby: classes are objects too (instances of Class) and so have instance variables.
One thing to look out for is that each subclass will have its own set of class instance variables (after all these are different objects): If you subclassed DummyClass, class methods on the subclass would not be able to see @arr.
Class variables (@@foo) are of course the other way round: the entire class hierarchy shares the same class variables.


Living with a disability is not easy. But through a variety of resources, Easter Seals Cardinal Hill helps people with all types of abilities get the care that is right for them.
Our resources include everything from funding options and addressing aging challenges to building a relationship with your doctor. We know it's important to know your options for Adult Care and have access to research about what it's like to live with a disability.


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Q: Parse Error When Trying To Use theme() Inside calc() I'm using Tailwind CSS with PostCSS via Gulp. Just about everything works great. I'm trying to reference values from the config theme object in my CSS. I'm able to do the following just fine:
height: theme('spacing.12');

However, when I try to use theme() inside of calc() (just like in the documentation):
height: calc(100vh - theme('spacing.12'));

I get a Parse error from gulp-postcss ("Expecting 'SUB', 'LPAREN'....")
Is this a Tailwind bug?

A: It turns out it was an issue in my tool chain. Specifically, I was using the node package postcss-cssnext - which it turns out is deprecated. Once I removed this from my Gulp file, the error went away:


Our new bestseller! Our Abella Geode Crossbody comes in three colors - Natural, Light Grey, and Black. All stones are unique and may vary in size and color.
Bag measures 8.5" tall and 5.5" Wide. Perfect fit for phone, small wallet and lipstick.


Vegas 5 Man - Shirt orders.
2004 Vegas 5 Man - THIS WEEKEND!!!
LQ Atlanta - May 2004?
Vegas 5 Man - Teams confirmed.
Just What We Really Wanted For Christmas!
Vegas 5 Man - Poker Party: Dealer Update!
NEED A 5th FOR VEGAS!!!
How to diffuse the fog from a fog machine?


All our plaques our Custom Made of multi-woods, Oak and Walnut. We use the Oak for the Center wood and the Walnut for the outside edges to give the plaque a contrast look. Our Skull Plaques can be either a table top stand, or hung on the wall.
We do not use wood screws, but instead use bolts with inserts, so it will not matter how many times you want to change from table top to wall hanging, and back, you will never have to worry about the holes being enlarged.
This picture is of all Cherry. Look at the Bear and Deer pictures to see the correct wood combo.


The Netball Association will having its Annual General meeting and Election of officers for a new term on Saturday February 8th 4:30 pm at the Thomas Saunders Secondary, all Teams and Clubs are ask to please take note.
You are reminded to collect the minutes of the meeting and your nomination forms from Thelma Foster at Public Works and Gloria Ballantyne at the Society of and for the Blind.
Additionally, the deadline for the submission of the Nomination Forms have been extended to the 30th January and can be returned to Secretary, Mrs. Doris Mc Intosh or President, Ms. Dellarice Duncan.


"Motor oil is the lifeblood of your car." I heard that in a commercial once, so it must be true. If you doubt the validity of that statement, ask anyone who has ever forgotten the simple but vital step in automotive maintenance called The Oil Change. I won't name names, but I have a sibling who once unintentionally tested how long her 1996 Chevy Cavalier could go between oil changes (a pretty long time, it turns out!). But at some point, the moving parts no longer have that smooth layer of oil covering them to ease their operation and reduce friction. Once enough friction builds up, the moving parts will fail and eventually the engine will stop working.
Grace functions much the same way in the church. The church has a lot of moving parts. We call them people. As the church operates, with each person serving various functions, occasional friction can build up between people. We've all experienced this with others and, if we're honest, we've all been the source of friction ourselves at times! When enough friction builds up between people, the church cannot function as it should. That is where grace comes to the rescue! Grace covers over us, coats us, eases our interaction with others and reduces friction so that we can work together to the glory of God.
As followers of Jesus, we are recipients of the amazing grace of God. We are sinners, totally undeserving of the grace and forgiveness of Holy God. Yet through the sacrificial death and resurrection of Jesus Christ, we receive the grace and forgiveness we so desperately need. Remember the Parable of the Unmerciful Servant that Jesus told of in Matthew 18:21-35? Like the servant, we have been forgiven a great debt to the King that we could never repay. We are obligated to extend grace and mercy to others. Paul writes in Ephesians 2:8-9, "For it is by grace you have been saved, through faith—and this is not from yourselves, it is the gift of God— not by works, so that no one can boast." In light of this grace, Paul later writes in Ephesians 4:32, "Be kind and compassionate to one another, forgiving each other, just as in Christ God forgave you." We all mess up. We all say or do things we shouldn't, or fail to do or say things we should. These failures cause friction between us. But if we give grace to others, even if they don't deserve it, it reduces friction and the church keeps running as it should. So don't forget to give grace to others. And it wouldn't hurt to check your oil.


Designed to grace your garden year round, each piece of Haw Creek Forge garden stakes and outdoor wall art is hand crafted with metal working techniques to create the detailed yet whimsical and elegant outdoor sculpture.
Finished with UV resistant paint and/or a patina to create an aged effect along with a durable clear coat, each piece is an outdoor garden decoration.
We encourage you to shop locally. If you do not find Haw Creek Forge work in your area, we are happy to have you shop online with us.


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Prototype (16) Apply Prototype filter
BODIPY-FL Nilotinib (Tasigna) for Use in Cancer Research
The National Cancer Institute''s Laboratory of Cell Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize bodipy conjugated tyrosine kinase inhibitors that are currently used in the clinic for the treatment of CML or gastric cancers.
Improved Production of Prenylated Protein in Insect Cells
The National Cancer Institute seeks parties interested licensing and/or collaborative research to co-develop research materials for improved production of prenylated proteins.
Methods of Producing Effective T-cell Populations Using Akt Inhibitors
Adoptive cell therapy uses cancer reactive T-cells to effectively treat cancer patients. Producing many persistent T-cells is critical for successful treatments. Researchers at the NCI seek licensing and/or co-development research collaborations for a novel method of producing effective T-cell populations using Akt inhibitors.
Parental A2780 Ovarian Cancer Cell Line and Derivative Cisplatin-resistant and Adriamycin-resistant A2780 Cell Lines
The National Cancer Institute (NCI) seeks non-exclusive licensees for an ovarian cancer cell line, A2780, and its cisplatin- and/or adriamycin-resistant derivatives, A2780CIS and A2780ADR. These cell lines are excellent research tools to study ovarian cancer with a focus on drug resistance.
High-throughput Assay to Identify New Cancer Drugs
The National Cancer Institute seeks parties interested in collaborative research to evaluate or commercialize a diagnostic tool that can identify new drugs that increase chromosome instability.
A Preclinical Model for Mutant Human EGFR-driven Lung Adenocarcinoma
The National Cancer Institute (NCI) has a human epidermal growth factor receptor- (EGFR) driven tumor mouse model of lung adenocarcinoma available for licensing.
A Novel Carbohydrate Antibody to GalNac1-3Gal and Its Application for Cancer Diagnostic and Prognosis
The National Cancer Institute (NCI) seeks licensees for a monoclonal antibody specific to the GalNAc1-3Gal antigen that is present in human carcinomas. The antibody can be used as a research tool for a variety of purposes, including immunohistochemical staining of various human carcinomas. The antibody may also be useful as a prognostic marker for cervical cancer.
Target for Anti-Tumor Immune Responses
The Surgery Branch of the National Cancer Institute is seeking statements of capability or interest from parties interested in collaborative research to carry out genotypic as well as phenotypic analysis of the 888 mel cell line in order to better understand the nature of tumor cells that respond to therapy.
Brain endothelial reporter cells
The National Cancer Institute seeks parties interested in co-development of safe and effective TEM5 agonists and/or antagonists that modulate WNT signaling.
89Zr-Oxine Complex for In Vivo PET Imaging of Labelled Cells and Associated Methods
The National Cancer Institute seek parties interested in in-licensing and/or collaborative research to develop and commercialize cell labeling, cell tracking, cell trafficking, cell-based therapy, and PET imaging for cancer.
CytoSig: A Software Platform for Predicting Cytokine Signaling Activities, Target Discovery, and Clinical Decision Support System (CDSS) from Transcriptomic Profiles
Scientists at the National Cancer Institute (NCI) have developed the Cytokine Signaling Analyzer (CytoSig), a software-based platform that provides both a database of target genes modulated by cytokines and a predictive model of cytokine signaling cascades from transcriptomic profiles. NCI seeks collaborators or licensees to advance the development of CytoSig for research, target discovery, or as a Clinical Decision Support System (CDSS).
Assay to Screen Anti-metastatic Drugs
The National Cancer Institute seeks licensees for a model used to study molecular mechanisms and/or signaling pathways involved in tumorigenesis, angiogenesis and metastasis of breast cancer and its response to therapy.
Niclosamide for Treating Adrenocortical Cancer (ACC)
Researchers at the NCI have developed a novel treatment for adrenocortical cancer (ACC) by repositioning the drug niclosamide. New treatments for ACC can help patients with this rare and aggressive disease, where the current standard of care involves highly toxic options. The NCI seeks parties to license this method of treating adrenocortical cancer using niclosamide.
Humanized Mouse Model to Study Mesothelin (MSLN) -targeted Cancer Therapeutics: Bl6/TPO Mice
The National Cancer Institute (NCI) seeks licensees for humanized mice that express the human isomer of mesothelin (MSLN) in the thyroid. NCI created Bl6/TPO mice for studies of mesothelin as a target for research, diagnostic, or therapeutics involving human cancers.


I watched a weaboo video that @Desu posted.
They use the xsolla payment service, which can accept a wide range of currencies, as far as I'm aware.
I can't wait for April 1st PTS. Will be very disappointed if it doesn't happen.
The Breeding Guide used to have a visual like this, however the hosting site deleted the image after so much time. If it is ok with you, I would like to use this image as a replacement. lmk.
Yeah, the issue came while exploring permutations. I think it was something along the lines of: What's the most efficient way to use a 3x31 natured that was obtained while just trying to make a regular 3x31. The possibilities became so large for the program that it was too slow. Maybe there's a simpler way to go about it, but the one driving this thing kinda left fairly early, and I got too busy to devote time to it.
Yeah it is a dead idea. Ran into issues figuring out how to calculate the ideal path to take in breeding.
;) When it comes to my labcoat I get super wishy washy. Not gonna lie, woke up this morning thinking that I was an idiot last night. Then throughout the day I've been thinking about it more lol. I don't think I have the commitment level to do 50 events over several months; if I did, I would rejoin staff. So then, naturally I would cut down the number of events to like 10 or something. But then that doesn't feel grand enough... Also, I wouldn't want 1 or 2 people to just outright buy all the tickets, but I don't want to make the tickets untradeable, because then people would play in the events with 0 reward in the interim (and then there's the chance that someone could win all the events and then lose out to someone who won 3rd place once and as a result get nothing for their feats). So yeah I'm conflicted. I think the idea may be just too flawed for me to pull the trigger.
So, I want to get some feedback on an idea that just popped into my head tonight. This isn't concrete and I may decide in the morning that I don't want to do it. But anyways, the idea: 1. Have Staff hold my labcoat. 2. Propose a lottery of X tickets (was thinking maybe 500, so each ticket would be worth roughly 4m each, assuming labcoat is ~2bil) where the winner gets the labcoat. 3. The primary way to obtain a ticket would be to place in an event hosted by me. These events would range across all pvp tiers, pve, and things like art/video/music contests. Going off of 500 tickets, I would think that each event would give 10 tickets as a total prize (5 to 1st, 3 to 2nd, and 1 each to 3rd and 4th), so ~40m in prizes per event, and a total of 50 events over several months or something. 4. You can trade these "tickets" to anyone. That's essentially the gist of it. Obviously I'd have to come up with a set schedule, would need people to help me host (maybe give a ticket to people every 5 times they help me host or something?). But, yeah. Thoughts? Am I crazy? Would this even be hype? Curious what you guys think. inb4 morning me thinks I'm an idiot.


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Follow the latest news and information about voting and the 2020 election, including essential information about how to vote during a pandemic and more.
Dominion Voting Systems Suing Giuliani For Defamation
CPR News | By Bente Birkeland
Rudy Giuliani, seen here on Jan. 6 with Chapman University law professor John Eastman, speaks in Washington at a rally in support of President Donald Trump. Dominion Voting Systems, a frequent target of Giuliani, is suing him for defamation.
Dominion Voting Systems has filed suit against President Donald Trump's personal attorney Rudy Giuliani over baseless claims he's made that Dominion was at the center of a scheme to perpetuate widespread election fraud.
The Denver-based company, which is seeking $1.3 billion in damages from Giuliani, provides election equipment and software to 28 states, including the majority of the equipment used in the swing states on which Trump and his surrogates focused most of their post-election ire.
"Rudy Giuliani actively propagated disinformation to purposefully mislead voters," Dominion CEO John Poulos said in a statement. "Because Giuliani and others incessantly repeated the false claims about my company on a range of media platforms, some of our own family and friends are among the Americans who were duped."
This is the second defamation lawsuit the company has filed in recent weeks. On January 8, Dominion sued Sidney Powell, a lawyer who previously worked for the Trump campaign, seeking $1.3 billion in damages. The company argues that Powell's "viral disinformation campaign" has destroyed the value of its business.
An attorney for Dominion said additional lawsuits against pro-Trump media outlets, such as Fox News, and even Trump himself are possible. Both of its current suits are filed in the U.S. District Court for the District of Columbia.
"These lies have had an incalculable amount of damage on Dominion and our country," Dominion legal counsel Thomas Clare said in the statement. "We will hold him [Giuliani], and the many that have abetted him, accountable for their profiteering lies."
On a call earlier this month, Clare said the goal is to take these cases out of the realm of the media and to trial. "The best way to vindicate the truth is in the courts where there's cross-examination where we have the opportunity to take discovery, where there are rules, where evidence is required to be submitted. And that is the process that we are very much looking forward to in order to vindicate the company and to get the truth out there."
Giuliani and Powell made numerous false claims about Dominion in the weeks after the election. In mid-November Giuliani appeared on Fox News' Lou Dobbs Tonight and referred to Dominion as a company that was "strange" and "very frightening."
"So we're using a foreign company that is owned by Venezueluans who were close to Chavez and are now close to Maduro, and they are extremely hackable," said Giuliani.
Dominion was founded in Canada in 2003 and has no ownership ties to Venezuelan leadership.
A top employee of Dominion Voting Systems, Eric Coomer from Colorado, has been in hiding since shortly after the election when he became the subject of conspiracy theories that he'd masterminded a high-tech plot to steal the election for President Joe Biden. It's a charge Coomer categorically denies. In late December Coomer sued Giuliani, the Trump campaign, and several pro-Trump media outlets, among others, alleging defamation.
Coomer's suit was filed in state court in Denver and accuses those responsible of spreading the falsehoods of intentional infliction of emotional distress and civil conspiracy. He said he remains in fear for himself and his family.
"I've been threatened more times than I could even count. Whether it's the standard online trolls, voicemails that are left almost on a daily basis, being called a traitor to this country. I can't even begin to describe what effect this has had on my life," Coomer told Colorado Public Radio in December.
Republican and Democratic state election officials certified Biden's victory with no evidence of widespread fraud or irregularities. Audits showed that Dominion's machine tabulations matched the tallies that were on the paper ballots.
Dominion has said the weeks of conspiracy theories are not just dangerous for the country and for democracy, but have had a huge human toll, and done untold damage to the company's reputation and finances.
Giuliani's legal troubles don't end with Dominion. Some prominent attorneys are also calling for his law license to be suspended. According to the New York Times they allege he trampled ethical boundaries when he helped Trump pursue false claims of election fraud.
Copyright 2021 CPR News. To see more, visit .
Politics2020 Election
Bente Birkeland
Bente Birkeland has been reporting on state legislative issues for KUNC and Rocky Mountain Community Radio since 2006. Originally, from Minnesota, Bente likes to hike and ski in her spare time. She keeps track of state politics throughout the year but is especially busy during the annual legislative session from January through early May.


What happened when brave gunman-charger Ben Carson was actually held up at gunpoint?
GOP presidential hopeful Ben Carson appeared on SiriusXM's "Karen Hunter Show" Wednesday evening and told a decidedly different tale about what he would do when confronted by an armed gunman.
The retired neurosurgeon is apparently a fan of the "do as I say I would do, not as I actually did" school of punditry, as he related to Hunter what happened in a Baltimore Popeye's when a robber "stuck a gun in [his] ribs."
"I have had a gun held on me when I was in a Popeye's organization," he said. "Guy comes in, put the gun in my ribs."
Carson calmly recounted how he calmly responded, "I just said, 'I believe you want the guy behind the counter.'" In other words, instead of charging the gunman, as Carson recommends other Americans do, the good doctor directed the man to the likely teenage, certainly minimum-wage-earning employee.
That's a far cry from the bravery he boasted he would show if ever confronted by a heavily armed gunman, but it makes a kind of sense -- the robber only had one gun, far below the minimum required for Carson to display his vaunted daring.
Listen to the Carson speaking with Hunter below via SiriusXM.