text:
Negotiators optimistic on pension bill
By William L. Watts
Published: July 20, 2006 6:59 p.m. ET
Top lawmakers hope for action next week
WilliamL. Watts
WASHINGTON (MarketWatch) -- Top lawmakers say that they're getting close to a final agreement on complicated legislation designed to shore up the nation's defined-benefit pension system.
"We had a very productive meeting yesterday, a frank discussion about the remaining items. We'll meet again today to try to complete that," House Majority Leader John Boehner told reporters Thursday, referring to ongoing House-Senate negotiations to resolve differences between the two chambers' versions of the package.
"I'm going to reiterate: We don't have a commitment or an agreement yet, but I think we're very close to having one," said Boehner, who expressed hope that Congress would be able to vote on a final package next week.
Senate Health, Education, Labor and Pensions Committee Chairman Mike Enzi, R-Wyo., told reporters late Wednesday that negotiators had reached a tentative, verbal agreement on the package.
House and Senate negotiators have been meeting since March in an effort to resolve differences between their versions. See related story.
Around 44 million Americans have defined-benefit pensions, which pay retirees a fixed amount based on length of service and salary history. But pensions are underfunded by around $450 billion, and the federal Pension Benefit Guaranty Corp., which is funded by corporate premiums and investments, is running a deficit of more than $22 billion.
The House and Senate bills both require most companies with underfunded pensions to make up shortfalls within seven years, but differ on a range of provisions. Business lobbyists have been fighting hard for a range of breaks and other measures designed to ease the burden on clients.
Boehner offered no guidance on how the final bill will treat financially troubled airlines. The Senate version of the bill gave strapped airlines up to 20 years to make up funding shortfalls. He said that the issue remains to be resolved.
Top executives from Northwest Airlines Corp. NWACQ and Delta Air Lines Inc. DALRQ have visited Capitol Hill this week, urging lawmakers to complete work on the pension legislation and warning that they would likely be forced to terminate their pension plans -- foisting them on the PBGC -- unless new funding rules are soon put in place.
"My airline CEO meeting yesterday was like most meetings that I have: People come in and want something. And [there are] a lot of people who want things. ... I told them that I was for reasonable and responsible relief for troubled industries," Boehner said.
The package is also expected to serve as a vehicle for a number of expired or soon-to-expire tax provisions, including the research and development credit and the deductibility of state and local sales taxes.
Senate Republican leaders, meanwhile, were attempting to attach language to the bill that would roll back the estate tax.
"Many supporters of American small businesses and farms agree that this is the last, best chance to fix the death tax once and for all," said Amy Call, spokeswoman for Senate Majority Leader Bill Frist, R-Tenn.
Her statement came after Senate Minority Leader Harry Reid, D-Nev., said that such a measure would not pass the Senate.
"Fiscally irresponsible estate-tax giveaways have been rejected by the Senate before and will be rejected again. ... I hope my Republican colleagues will move in a new direction by dropping the estate-tax giveaway so we can quickly pass the pensions conference report," Reid said in a statement.


text:
Q: SciKit-learn grid search own scoring object syntax I want to search hyper-parameters in a convolutional net built with Keras. For this I am using the KerasClassifier and GridSearchCV from SciKit-learn in line with a good intro that is given here MachineLearningMastery.
Typically SciKit-learn optimizes on 'accuracy', however my network runs image segmentation optimizing the Jaccard index. So I need to define my own scoring object for the grid search using make_scorer as explaned here make_scorer and here defining your scoring strategy. The code section below shows my implementation, but I am getting an error in model.compile(optimizer=optimizer, loss=eval_loss, metrics=(['eval_func']), where I do not know what to specify in metrics. Default is 'accuracy' but I would assume in my case this would be 'eval_func' (which works when not doing grid search) or 'score' but neither of these works in this case.
What is the right syntax?
def eval_func(y_true, y_pred):
    '''Evaluation function dice or jaccard, set with global var JACCARD=True'''
    if JACCARD:
        return jaccard_index(y_true, y_pred)
    else:
        return dice_coef(y_true, y_pred)

def get_unet(batch_size=32, decay=0, dropout_rate=0.5, weight_constraint=0):
    '''Create u-net model'''
    dim = 32

    inputs = Input((3, image_cols, image_rows)) # modified to take 3 color channel input
    conv1 = Convolution2D(dim, 3, 3, activation='relu', border_mode='same', W_constraint=weight_constraint)(inputs)
    conv1 = Convolution2D(dim, 3, 3, activation='relu', border_mode='same', W_constraint=weight_constraint)(conv1)
    pool1 = MaxPooling2D(pool_size=(2, 2))(conv1)
    pool1 = Dropout(dropout_rate)(pool1) # dropout added to all layers

    ... more layers ...

    conv10 = Convolution2D(1, 1, 1, activation='sigmoid')(conv9)

    model = Model(input=inputs, output=conv10)

    optimizer = Adam(lr=LR, decay=decay)
    model.compile(optimizer=optimizer, loss=eval_loss, metrics=(['eval_func'])

    return model

def run_grid_search():
    '''Optimize model parameters with grid search'''

    ... loading data ...

    model = KerasClassifier(build_fn=get_unet, verbose=1, nb_epoch=NUM_EPOCH, shuffle=True)
    # define grid search parameters
    batch_size = [16, 32, 48]
    decay = [0, 0.002, 0.004]
    param_grid = dict(batch_size=batch_size, decay=decay)

    # create scoring object
    score = make_scorer(eval_func, greater_is_better=True)

    grid = GridSearchCV(estimator=model, param_grid=param_grid, scoring=score, n_jobs=1, verbose=1)
    grid_result = grid.fit(X_aug, Y_aug)

Here is the last part of the error I am getting both using 'eval_func' and 'score':

File "C:\Program
  Files\Anaconda2\lib\site-packages\keras\metrics.py", line 216 , in get
      return get_from_module(identifier, globals(), 'metric')   File "C:\Program
  Files\Anaconda2\lib\site-packages\keras\utils\generic_utils.p y", line
  16, in get_from_module
      str(identifier)) Exception: Invalid metric: eval_func

A: You should unquote it when passing to compile. Keras recognizes metrics in quotation marks only if they're part of the Keras API. See Keras.io/metrics.
This is the problem:
model.compile(optimizer=optimizer, loss=eval_loss, metrics=(['eval_func'])

You should fix it to:
model.compile(optimizer=optimizer, loss=eval_loss, metrics=([eval_func])

Hope it helps!

A: By default scikit-learn uses the score function in the estimator, if it exists at all. So you could just override the score function in KerasClassifier.
class MyEstimator(KerasClassifier):
    def __init__(self, **kwargs):
        super(MyEstimator, self).__init__(**kwargs)

    def score(self, X, y):
        y_pred = self.predict(X)
        return eval_func(y, y_pred)

redpajama_set_name: RedPajamaStackExchange


The first EIXIR CZ annual conference. Poster, registration and programme details further below.
Presentations will be delivered by the ELIXIR CZ infrastructure members. Each institution will be presenting their key services delivered to the infrastructure users or specific use cases showing how research can benefit from the use of ELIXIR infrastructure. See this Conference poster for more details on the areas covered.
Note : The conference will be held in Czech.


text:
Q: How to properly know from which edge a UIScreenEdgePanGestureRecognizer comes from? I have added a UIScreenEdgePanGestureRecognizer on left and right edges of the screen.
So far, to know from which edge the pan is coming from, I based it on the translation. If it is < 0, it comes from the right edge, if it is > 0 it comes from the left edge.
But in landscape, I realized that if for example you start panning from the right edge to the left (translation < 0) and then come back to the right edge and keep panning out of the screen, then the translation becomes positive at a point.
I thought to affect a variable in UIGestureRecognizerState.Began and check it in UIGestureRecognizerState.End instead of the translation but I'm not sure it is the best way.
So my question: what is the best way to check from where comes the screen edge pan?


Aprilia RSV4 Akrapovic Muffler, Suits 2009 -2010 models Carbon muffler with titanium pipe, good s/hand item with only minor scratches, please refer to photos for full description.
Genuine Aprilia Racing Mufflers (pair) suit '04 - '08 RSV R These mufflers were removed from a new bike and have seen no road miles and are in excellent condition. Two pairs available!!


text:
Shaman's Harvest w/ Legends Fade, Dogs on the Lam, & Brian Ward Band
Diamondz Event Center
Tickets are $15 in advance, $20 day of show, and may be purchased online at JeromeTickets.com or an opening band member.
There are also a VERY SMALL number of Reserved tickets available for $25. They get you a reserved seat so you don't have to be at the front of the line to grab one (like you'll be sitting anyway, lol).
To attend, you must be 15+ with a parent or guardian, or 18+ otherwise. Full bar available to those 21+ with valid ID. Doors are at 6:00pm, show starts at 6:30pm.
Say you're coming to one of our events and get a $59 double room from Quality Inn & Suites. Add another $5 and upgrade your room to a full suite! They're at 1910 Fillmore Ave N in Twin Falls, (208) 734-7494.
--- SHAMAN'S HARVEST ---
Deep inside Missouris capital city, you will find one of the most amazing bands to emerge from the Midwest. This 5-piece features Nathan Drake Hunt on vocals, Josh Hamler on guitar, bassist Matt Fisher, Derrick Shipp on lead guitar and Adam Zemanek on drums. Together, they have formulated their own unique mix of modern and classic rock with a southern twist that has energized fans across the nation.
Shamans Harvest has successfully endured a long journey and cultivated a large national fan base. Dragonfly, from the album SHINE, truly showcased their unique ability to create a dynamic original sound. Their debut single from the critically acclaimed album landed on both the Billboard Active Rock (#13) and Heritage Rock (#9) charts and set the boys up to be one of the biggest truly independent rock bands of today. This brought on national tours with Adelitas Way, Puddle of Mudd, Black Stone Cherry, AC/DC, and not to mention the largest of national festivals. The bands hard work and dedication to touring catapulted them into the spotlight and opened doors to many opportunities including professional sports teams, WWE wrestlers, and movie soundtracks using Shamans Harvest songs.
Spending most of 2012 in the studio, Shamans Harvest continues to forge ahead with their Fifth full-length album titled Smokin Hearts & Broken Guns due for release late summer 2014 featuring Dangerous as the first single. In support of the new album, Shamans Harvest will be hitting the road in 2014 bringing their unique style of Rock n Roll to a venue near you.
https://www.youtube.com/watch?v=M4sQfHD_b_E
https://www.youtube.com/watch?v=rInmvUKYeKA
https://www.youtube.com/watch?v=1NHV6NUEKNU
https://www.youtube.com/watch?v=V9c44jhm_II
https://www.facebook.com/shamansharvest/
http://shamansharvest.com/
https://en.wikipedia.org/wiki/Shaman's_Harvest
--- Legends Fade ---
We're stoked to have these Idaho Falls Rockers back on our stage. If you don't know of them, they're members of Break The Broken and 2am Logic. Don't miss this set, my friends!
https://www.facebook.com/LegendsFade/
"Its not destiny or serendipitous grand design, its hard work paying off." Pulling together members from 4 successful bands in 4 different genres, Legends Fade is a collection of dedicated musicians poised for big achievements and driven to produce songs that stand the test of time. Bonded by the motto Love shouldnt hurt, the band has adopted domestic violence awareness and prevention as their core cause. With heavy focus being placed on putting on a great live show, and already working with national touring bands P.O.D, Royal Bliss, Powerman 5000, Hed PE, and Buried as Thieves, Legends Fade is a rock band that's ready to bring their music to the masses.
--- Dogs on the Lam ---
And we're bringing back Diamondz favorite Dogs on the Lam!
https://www.facebook.com/photo.php?v=1433078001549&set=vb.145295562171534&type=3&video_source=pages_video_set
https://www.facebook.com/Dogs-on-the-Lam-127716843914072/
--- BRIAN WARD BAND ---
Brian's back, and we couldn't be happier. Come check out this amazing guitar player and his all-star band!
http://www.brianwardband.com/#!
https://www.facebook.com/brianwardband
https://www.youtube.com/watch?v=6uDDtgnZAxg
https://www.youtube.com/watch?v=yEYEEXn9z8w
Diamondz Event Center (View)

redpajama_set_name: RedPajamaCommonCrawl


The Best of July and August 2014 goes to two very popular restaurants for brunch. Prune in East Village and The East Pole on the Upper East Side.
Even though I love brunch food, I have never been a brunch person until I moved to NYC last summer. I really enjoyed both Prune and The East Pole and they were my best pick for this month.
Prune has a very unique menu. They have their take on bacon and eggs, Spaghetti a la Carbonara on their brunch menu for example. I chose a fried oyster omelet which is also unusual, I think. I love fried oysters but I never thought about eating it for brunch. The fried oyster was so creamy inside and crispy outside. It was perfect.
At The East Pole, I had a tasty and very pretty "all greens omelet" with ricotta cheese and fresh herbs. The egg was so fluffy and beautifully yellow. They used a bunch of fresh herbs and greens inside-out with some soft ricotta cheese inside. It is light and does not make you feel full like most of the heavy brunch menu items. I also tired their home fries. It is more like hash than fries and heavy in oil. But the black garlic makes this dish super flavorful.
The best dish of the month goes to the Porchetta alla Romana from Il Bucco Alimentari & Vineria. It was an unexpectedly beautiful dish with seasonal vegetable and peaches over a slice of very tender and moist porchetta. Some porchetta has very salty, crispy skin but the one served at Il Bucco was much milder and the texture is similar to pork roast. Maybe it is not made the classic way but I was very happy with it. The service was friendly and attentive even when I was sitting at the bar. I will definetly go back soon.


The Research Works Act will prohibit federal agencies from unauthorized free public dissemination of journal articles that report on research which, to some degree, has been federally-funded but is produced and published by private sector publishers receiving no such funding. It would also prevent non-government authors from being required to agree to such free distribution of these works. Additionally, it would preempt federal agencies' planned funding, development and back-office administration of their own electronic repositories for such works, which would duplicate existing copyright-protected systems and unfairly compete with established university, society and commercial publishers.
I recommend reading the AAP's statement in full — it's truly head-spinning. If this legislation goes through it would be a major blow to open access to scholarly research and publishing. And this comes on the heels of the (unsurprising, yet still disappointing) news that SOPA (Stop Online Piracy Act) and the PROTECT IP act are also strongly supported by many commercial publishers.
Even more troubling are details on campaign contributions for the representatives who sponsored the act, Rep. Darrell Issa (R-CA) and Rep. Carolyn Maloney (D-NY). Biologist Michael Eisen used MapLight to learn that Elsevier contributed funds to Representative Maloney's campaign last year. Anthropologist Jason Baird Jackson found Representative Issa's name on Elsevier's contributions list as well.
If this makes you furious (as it does me), you're probably wondering what we can do beyond writing emails or phone calls to register our disagreement with these legislative acts. Here are some ideas — please share more in the comments!
Keep talking! Every time the commercial publishers come out in support of restricting access to scholarly research it's another opportunity to widen the open access conversation. John Dupuis at Confessions of a Science Librarian and others have called for scholarly societies to resign their memberships in the AAP. What else can we say in support of open access in conversations with colleagues, faculty, and administrators?
Familiarize ourselves with the issues Many of us have likely perused the wide range of top notch resources out there on open access scholarly publishing. Peter Suber's excellent overview of open access is a great place to start, and I highly recommend sharing it with those interested in learning the basics. To keep up with OA news and developments I follow Open Access Tracking Project on Twitter, or visit the Open Access Directory hosted by Simmons College.
Know where to go The louder the open access conversation gets, the more colleagues, faculty, and administrators are likely to come to us with questions. The DOAJ (Directory of Open Access Journals) is a great place for scholars to start looking for open access journals to publish their research, and SHERPARoMEO has a wealth of information on both OA and toll access publishers' copyright and self-archiving policies.
Practice what we preach It goes without saying that we should make every effort possible to publish our own research in open access venues. Jason Baird Jackson's classic Getting Yourself Out of the Business in Five Easy Steps is well-worth a read for its sound advice on transitioning from commercial to open access publishing in all aspects of our participation in the scholarly communications system.
As academic librarians we've been advocates for open access for a long time, from the very beginning of the serials crisis (and far longer than I've been in the profession). But as these recent legislative acts demonstrate, it's never been more important to push for ethical publishing practices and access to scholarly research.
Edited to add: The White House has extended the deadline for comments on open access to scientific publications to January 12, which is another way for us to express our support for OA (hat tip @brettbobley).
Do we know which subcommittee this will go to within the House Committee on Oversight and Government Reform?
Is this the "Subcommittee on Technology, Information Policy, Intergovernmental Relations and Procurement Reform"?
So far there's no subcommittee listed on Thomas.gov — looks like there hasn't been any action on this since mid-December: http://thomas.loc.gov/cgi-bin/bdquery/z?d112:h.r.03699:. I hope that the voluminous expressions of outrage all over the internet help quash this — John Dupuis is maintaining a great list of everything posted so far.
Pingback: ACRLog » What Are the Next Steps?


This song is mostly recognized world-wide as a "Dino" signature classic!
( "We danced that night, to candle light, the world was white with snow... the way we felt, we never felt, the snow could melt and go." A great song that was also the title track of Dean Martins first "season" themed album, "A Winter Romance" for Capital Records...It's perfect for ski resorts, hotels and country club special "Winter Romance" marketed events!.
Although heard during holidays, all of these songs are winter season songs that don't even mention holidays in the lyrics!
( I really can't stay -but baby, it's cold outside- got to go away-but baby, it's cold outside"...) A really fun song when "Dino" has a lady guest join him in duet, with lyrics provided of course!
As a great show perfect for entertaining special events coast to coast, from Thanksgiving through late February, during the time between Thanksgiving and New Years Eve the show also includes these beloved Christmas classics.
"It's Beginning To Look A Lot Like Christmas,"
"I'll Be Home For Christmas,"
"Rudolph The Red Nosed Reindeer" and "Jingle Bells."
"Everybody Loves Somebody," "That's Amore' " "Memories Are Made Of This," "In The Misty Moonlight," "Sway," "Little Ole Wine Drinker Me," "Houston," "Sway," "I Will," "Mambo Italiano," "In The Chapel In The Moonlight," "Just In Time" and more with those classics and you'll have everyone dancing, laughing, singing along and applauding with great cheer!
Also contact us HERE for many more photos, details, rates, etc!


I am delighted to have been asked to be the inaugural President of the Uplands Alliance. The Uplands may only cover 17% of our land mass but are disproportionately important to what it means to be English – and indeed British. They encompass our most loved landscapes, from the Lakes in the West to the North York Moors in the East, from the Cheviots in Northumberland to Bodmin in Cornwall and many wonderful areas in between. The challenge is that now they are too often contested spaces as the demand for what they add to more and more peoples' lives increases.
The Alliance brings together practitioners, policy makers and researchers. We are creating a 'policy lab' to maximise outputs from current programmes and to develop together new approaches for the future.
My own work and interests include estate management, farming, nature conservation, and business. With a bit of thought and imagination the Uplands can support all these and the communities who live there. Join us in making this a reality.


Montafonappartement - Your holiday dream in the heart of the Montafon!
..... to the Montafon apartment in Tschagguns. The place where your holiday dreams will come true.
Make yourself feel comfortable in a four room deluxe apartment with a fully equipped kitchen, bathroom, living room and three bedrooms in country style.


text:
Case Reports in Clinical Medicine
Vol.3 No.5(2014), Article ID:45762,5 pages DOI:10.4236/crcm.2014.35060
Concomitant Retroperitoneal Intramuscular Hemangioma and Intravascular Papillary Endothelial Hyperplasia: An Unusual Case Report
Ching-Yueh Lin1, Yu-Chun Lin2, Liang-Cheng Chen1, Yung-Tsan Wu1
1Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
2Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
Email: linchingyueh@gmail.com
Received 14 April 2014; revised 2 May 2014; accepted 11 May 2014
Primary retroperitoneal tumors are rare, and benign retroperitoneal tumors are exceptionally rare. Herein, we present a very rare case of benign concomitant retroperitoneal intramuscular hemangioma and intravascular papillary endothelial hyperplasia, with the unusual presentation of lumbosacral plexopathy. After surgical treatment and rehabilitation, the patient recovered uneventfully. This case report should serve to remind physicians of the rare condition of a retroperitoneal tumor leading to a neurological deficit.
Keywords:Hemangioma, Intravascular Papillary Endothelial Hyperplasia (IPEH), Lumbosacral Plexopathy, Masson's Hemangioma, Retroperitoneal Tumor
Primary retroperitoneal tumors are rare, accounting for only 0.07% to 0.6% of all tumors at the same location, and 62% to 82% of these tumors have been reported to be malignant [1] . Benign retroperitoneal tumors are rare, and vascular malformations such as hemangioma are exceptionally rare comprising only 0.5% to 2% of all retroperitoneal tumors [2] . In addition, intravascular papillary endothelial hyperplasia (IPEH) is an exceptionally rare disease, with only one case arising from the retroperitoneum published in the literature [3] . Herein, we present an unusual case with concurrent intramuscular hemangioma and IPEH in the retroperitoneum complicated with right side lumbosacral plexopathy.
A 56-year-old male with no systemic diseases or any history of surgery or trauma before this admission presented with abrupt pain in his right lower limb for 1 month, followed by right leg numbness 3 weeks later. A physical examination revealed a painful sensation with hypoesthesia in the right hip to lateral thigh, and a mild reduction in strength of the hip flexors and knee extensors. The X-ray and magnetic resonance imaging (MRI) of the lumbosacral spine showed no abnormalities, and the laboratory work-up was essentially normal. Lumbar strain was initially impressed, and he received conservative treatment for 4 weeks. However, he did not respond to this treatment, so advanced imaging was arranged.
MRI showed a large lobulated mass with heterogeneous intensity measuring 5 × 5 × 21 cm (anteroposterior diameter × width × height) along the right iliacus muscle. The mass was hypointense on T1-weighted images and hyperintense on fat saturation T2-weighted images, combined with several hypointense dots inside the mass (Figure 1). In addition, heterogeneous contrast enhancement of the mass on T1-weighted imaging was seen, and therefore a retroperitoneal tumor of vascular origin was highly suspected (Figure 2). To obtain pathological
Figure 1. Magnetic resonance imaging of the pelvis. Top: A hypointense, lobulated mass (5 × 5 × 21 cm, anteroposterior diameter × width × height) along the right iliacus muscle was shown on T1-weighted images (T1WI). Bottom: A heterogeneous, hyperintense mass with several hypointense dots inside and hypointense lining of the capsule were shown on fat saturation T2- weighted images (FS-T2WI).
Figure 2. Post-gadolinium axial and coronal T1-weight images showed heterogeneous contrast enhancement of the mass, causing medial dislocation of the right iliac artery and vein.
evidence and to prevent neurological deterioration, laparoscopic excision of the tumor was performed, and partial tumor invasion to the iliacus muscle was noted during the procedure.
Grossly, the tumor was a partially encapsulated cystic lesion containing friable thrombus-like material. Attached skeletal muscle tissue was also evident. Microscopically, an intramuscular hemangioma composed of one cystic dilated vascular channel and numerous associated irregular small vessels were seen. Thrombi formation with organization and papillary endothelial hyperplasia were also evident. Associated reactive myofibroblasts and capillary proliferation were seen in addition to the tumor (Figure 3). Based on the histopathological findings, an intramuscular hemangioma with IPEH was indicated.
The patient recovered uneventfully from the surgery except for persistent paresthesia in his right lateral thigh and muscle atrophy in his right vastusmedialis muscle. The muscle strength of his right quadriceps muscle was 3/5, and electrophysiological studies indicated right lumbosacral plexopathy. After intensive rehabilitation for 3 months, the strength of his right quadriceps muscle improved from 3/5 to 4/5, and he could perform most daily activities independently. After 5 years of follow-up, the neurological sequela was minimal and no recurrence of the tumor was noted.
To the best of our knowledge, this is the first reported case of concurrent retroperitoneal intramuscular hemangioma and IPEH-induced right lumbosacral plexopathy. Retroperitoneal hemangiomas are rare, and classified as cavernous, capillary, venous, and mixed types, with the last two types being extremely rare. They are usually asymptomatic except for tumor-related compression of surrounding tissue as the tumor grows. Although computed tomography and MRI are the standard methods for evaluation, the preoperative differentiation of malignant characteristics by imaging is often difficult. To prevent the tumor from rupturing/bleeding and to aid in differentiation, surgery is recommended [2] .
IPEH, also known as Masson's hemangioma, was first defined by Masson as a true neoplasm involving degenerative changes including thrombosis and necrosis, occurring when it expands beyond its blood supply [4] . In 1932, Henschen suggested the endothelial proliferation to be more like a reactive process, with endothelial proliferation and organization surrounding the thrombosis occurring during venous stasis [5] . In 1976, Clearkin and Enzinger proposed the term "IPEH", which was widely accepted thereafter [6] . To date, the exact pathogenesis of IPEH has not been clarified [7] .
In a literature review [7] -[12] , 23 cases of IPEH in the intraabdominal region were found, including the current
Figure 3. Left top: intramuscular hemangioma with thrombus formation; right top: intramuscular hemangioma; left bottom: intravascular papillary endothelial hyperplasia (arrow) (original magnification ×100). Right bottom: papillary endothelial hyperplasia (original magnification ×300).
case. Among these 23 cases [7] -[12] , 8 were reported in the renal vein (8/23, 35%), 3 in the adrenal gland (3/23, 13%), 5 in the gastrointestinal tract (5/23, 22%), 1 in the liver (1/23, 4%), 4 in the bladder (4/23, 18%), 1 with a multifocal lesion in the retroperitoneum and spine (1/23, 4%), and the current case in the retroperitoneum (1/23, 4%). Among the IPEH originating from the gastrointestinal tract, renal vein, and bladder, most were secondary to a comorbidity such as arteriovenous malformation (1 in the renal allograft and 2 in the jejunum), paroxysmal nocturnal hemoglobinuria (2 in the gastrointestinal tract), radiation therapy (4 in the bladder), and Wegener granulomatosis (1 in the spine and retroperitoneum). However, the IPEH from the adrenal gland and liver mostly had an unknown etiology.
IPEH is usually asymptomatic and often an accidental finding in radiological studies. However, uncommon symptoms resulting from tumor bleeding or peripheral organ compression such as epigastralgia, inguinal pain, low back pain, melena, and hematuria have been reported [7] [8] . No previous published case of a patient presenting with acute sciatica complicated with lumbosacral plexopathy was found in our literature review. This clinical presentation is very rare and mimics lumbosacral radiculopathy, however physicians should be aware of the possibility of retroperitoneal tumors when making a differential diagnosis.
The preoperative differentiation of IPEH is difficult because of its nonspecific clinical symptoms and radiographic features. IPEH may grow outside the vascular lumen after rupture of the vessel and spill over into the surrounding structures, which resembles invasive angiosarcoma. However, the malignant features in angiosarcoma such as high mitotic index, pleomorphism, or extensive necrosis should be absent in IPEH [7] [9] . Thus, surgical treatment with a histological diagnosis is necessary to avoid unnecessary chemotherapy or radiotherapy [7] . Fortunately, the prognosis of IPEH is excellent after surgery, as seen in the current case.
We present the first case of a huge retroperitoneal intramuscular hemangioma occurring concurrently with IPEH and complicated with lumbosacral plexopathy. This case illustrates a rare condition of coexisting benign tumors leading to progressive neurological deficits.
Godar, M., Yuan, Q., Shakya, R., Xia, Y. and Zhang, P. (2013) Mixed Capillary Venous Retroperitoneal Hemangioma. Case Reports in Radiology, 2013, Article ID: 258352.
Nakatsuka, S., Shigeta, N., Ojima, Y., Kimura, H., Nagano, T. and Ito, K. (2012) A Large Retroperitoneal Cystic Venous Malformation Mimicking Bilateral Ovarian Cystic Tumors. Archives of Gynecology and Obstetrics, 286, 1011- 1014. http://dx.doi.org/10.1007/s00404-012-2395-2
Petry, M., Brown, M.A., Hesselink, J.R. and Imbesi, S.G. (2009) Multifocal Intravascular Papillary Endothelial Hyperplasia in the Retroperitoneum and Spine: A Case Report and Review of the Literature. Journal of Magnetic Resonance Imaging, 29, 957-961. http://dx.doi.org/10.1002/jmri.21724
Masson, P. (1923) Hémangiendothéliome VégétantIntravasculaire. Bulletins de la SociétéAnatomique de Paris, 93, 517-523.
Henschen, F. (1932) L'endovasculite Proliférante Thrombopoïétiquedans la Lésion Vasculaire Locale. Annalesd'anatomiepathologique, 9, 113-121.
Clearkin, K.P. and Enzinger, F.M. (1976) Intravascular Papillary Endothelial Hyperplasia. Archives of Pathology & Laboratory Medicine, 100, 441-444.
Meadows, M.C., Sun, X., Dardik, M., Tarantino, D.R. and Chamberlain, R.S. (2010) Intraabdominal Intravascular Papillary Endothelial Hyperplasia (Masson's Tumor): A Rare and Novel Cause of Gastrointestinal Bleeding. Case Reports in Gastroenterology, 4, 124-132.
Jazaerly, T., Jaratli, H., Sakr, W., et al. (2011) Intravascular Papillary Endothelial Hyperplasia of the Bladder: Case Report and Review of the Literature. Avicenna Journal of Medicine, 1, 55-57.
Nassif, A.E., Pozzobon, H.J., Azevedo, E.Z., Taguchi, W.S. and Gomes, R.X. (2009) Papillary Endothelial Hyperplasia of Adrenal: Case Report. Revista do Colegio Brasileiro de Cirurgioes, 36, 277-278. http://dx.doi.org/10.1590/S0100-69912009000300018
Pelosi, G., Sonzogni, A. and Viale, G. (2011) Intravascular Papillary Endothelial Hyperplasia of the Renal Vein. International Journal of Surgical Pathology, 19, 518-520. http://dx.doi.org/10.1177/1066896909341800
Rizza, V., Coletti, G., Di Cocco, P., Mazzotta, C., Famulari, A. and Pisani, F. (2009) Serious Renal Hemorrhage in Masson Tumor. Transplantation Proceedings, 41, 1402-1404. http://dx.doi.org/10.1016/j.transproceed.2009.03.010
Tavora, F., Montgomery, E. and Epstein, J.I. (2008) A Series of Vascular Tumors and Tumorlike Lesions of the Bladder. The American Journal of Surgical Pathology, 32, 1213-1219. http://dx.doi.org/10.1097/PAS.0b013e31816293c5
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Muslims In the House: March 7-11, 2016
"A Canadian is a Canadian is a Canadian"
Debate in the House picked up mid last week with the Minister of Immigration John McCallum's introduction of Bill C-6. This is an act to amend Bill C-24, Strengthening the Canadian Citizenship Act, a Conservative bill passed by the previous government which among other things, allowed the previous Minister of Citizenship and Immigration to revoke an individual's citizenship if that person was convicted of a terrorist crime as well as other crimes. Minister McCallum asserted quite strongly in the House that all Canadians are equal and there cannot be two classes of Canadians, which is why the Liberal government found this law unacceptable and is amending it through Bill C-6.
B'nai Brith Accusations against Muslim Community Member
Conservative MP Peter Kent brought forth recent accusations by B'nai Brith against Mohammed Khalifeh, editor-in-chief of an Ontario based newspaper, Al Forqan. The Canadian Jewish human rights organization accuses the newspaper and editor-in-chief of "directly contributing to the radicalization of Canadian youth by glamorizing murderous attacks on civilians in Israel as a sacred religions duty".
Minister of Public Safety and Emergency Preparedness Ralph Goodale did not directly address MP Peter Kent's comment and assured the House that as indicated in the Liberal election platform, the government is working with provinces, communities and organizations across the country to develop a new system of community outreach and effective counter-radicalization initiatives.
Plight of Yazidi Girls
In light of international women's day, the plight of the Yazidi girls in Iraq was recognized in the House last week by Conservative members of the opposition including the Leader of Opposition, Rona Ambrose who questioned the Prime Minister's commitment in placing Yazidi girls in joint sponsorship programs.
Prime Minister Justin Trudeau assured the House that the Liberal Party committed to bringing 25,000 refugees from Syria and that the government is open to different suggestions and ways to continue to demonstrate that Canada is a place that will accept people.
In the continuing pressure of the opposition to address the Yazidi girls plight, Arif Virani responded that when the government does bring Syrian refugees, they do it in a manner that is "ethnically and religiously blind" which stands in stark contrast to the policies of the previous government.
Office of Religious Freedoms: Obsolete or Necessary?
The government's commitment to religious freedom was called into question this past week with Conservative MP Garnett Genius inquring as to whether the mandate of the Office of Religous Freedoms will be renewed. Parliamentary Secretary to the Minister of Foriegn Affairs (Consular Affairs) Omar Alghabra assured the House that the government is currently examining options on how to build and strengthen the work undertaken by the Office of Religions Freedom.


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Editorial | Decent public toilets a priority
The restrooms at the Savanna-la-Mar Public General Hospital in Westmoreland seemed most despicable.
There is a propensity among Jamaican officials to blame an absence of civic mindedness by citizens, and their supposed disregard for hygiene, for the squalor that exists in public spaces and in sections of too many public institutions. The solid waste management people and their governmental bosses tend to refer to people's so-called 'nastiness'.
While he did not make a full plunge, Christopher Tufton, the health minister, added a tepid toe to that blame game last week in an attempt to avoid accountability for the vileness of the public restrooms at several hospitals, which was highlighted by this newspaper on Sunday.
The minister acknowledged the Government's obligation for ensuring that state-run hospitals have clean bathrooms but suggested that public abuse of the facilities was a major cause of the decrepitude and filth reported on by The Sunday Gleaner.
"So you put new facilities in the bathroom – dispensers, toilet papers – and what we have found is that oftentimes, they go missing quickly because patients take those things," Tufton said.
In other words, toiletries, and, in some cases, hardware, including toilet seats and flapper balls for toilet tanks (taking into account the claims of Errol Greene, CEO of the South East Regional Health Authority) are being stolen by patients and visitors to the institutions.
We have no basis to question that conclusion by Dr Tufton, Mr Greene, or any of the other administrators, who were either ignorant of the state of the facilities or blamed the situation on the behaviour of outsiders.
PUBLIC RELATIONS DISTRACTIONS
We are concerned, though, about the manner in which the hospital bosses appear to be responding to the revelations – seemingly as public relations distractions, rather than a potential public health crisis. Either approach determines a posture that determines their philosophical approach to the fix.
In the former circumstance, it is a matter of rehinging some doors to toilet stalls; buying a few toilet seats and flapper balls; sourcing a few rolls of toilet paper; and, perhaps, placing some deodorants in the restrooms. Get past the immediate embarrassment, until the same problem, or something akin thereto, next makes its way into the public domain.
In embracing the latter approach, the issue is just a matter of cleaning toilets used by the public. For then, it is not separate from the hygiene of the entire health institution. Which makes it a fundamental matter of management.
Put another way, the scandalous state of the public toilets at these public hospitals is not entirely separate and cannot be ring-fenced from the matter of the 13 babies who died from bacterial infections at the Victoria Jubilee Hospital's maternal ward over the summer, or the 17 who died similarly, mostly at the University Hospital of the West Indies, in 2015.
Fortuitously, in those cases, the deaths were confined to maternity wards. Though late, crisis-response protocols worked in both cases.
However, by their very nature, hospitals and other healthcare institutions are susceptible to, and notorious for, the spread of bacterial infections. Bacteria abound in them.
The bugs are kept at bay from healthy people because healthcare workers – doctors, nurses, and other staff – generally adhere to established protocols for the management of these institutions, the most fundamental of which is hygiene. Cleaning and sanitisation are continuous. Indeed, the deaths of some of the babies in 2015 and this year were due, in part, to a stumble, if not full breakdown, in these regimes.
LIMITED COMFORT
It is only of limited comfort that the poorly maintained and broken, dirty toilets identified by The Sunday Gleaner were not on the wards or in specialised areas of the hospitals, where the contracting and transmission of infections is more likely. For poorly kept public toilets are notorious as places where bacteria linger, with potentially dangerous consequences.
Moreover, many of the people who use the public toilets at hospitals do so both before and after they visit wards. The possibility for taking infections to or from wards via toilets is obvious. Those risks are minimised by cleaning and proper maintenance.
That is why toilets at a healthcare facility, whoever uses them, should be subject to the same, or similar, cleaning protocols as the rest of the institution. Their upkeep, too, must be a priority.
These are among the least-cost elements of public-health management. They are preventative measures that save much – in money, and potentially, in human lives. It is, therefore, better to spend a few dollars more on these measures rather than scrimp on pennies and court danger.
Further, while we agree that Jamaicans should treat public restrooms with respect, that doesn't remove the responsibility for management to keep them clean and user-friendly. In many countries, restrooms at public facilities are constantly cleaned throughout the day – as a sanitary requirement and as a declaration of the quality of service managers want to deliver to the public. These jobs are usually the cheapest on an organisation's payroll.
But the approach is part of the philosophy of doing the little things continually and getting them consistently right, which Jamaica's public officials tend to get wrong too often.
«Michael Abrahams | Boy with the rocks
Gordon Robinson | Haemorrhoid on intimacy »


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Q: What is the best way to batch get on keys in Redis Cluster in response to a batch API? I'm using redis hashes to store metadata associated with a single key which in my case is userId. I have a batchAPI where I pass in a batch of userIds and get the metadata back. Redis Cluster doesn't support multi key commands so What's the best way to achieve this with RedisCluster? I am using Jedis as the Java Client to connect to Redis.

A: If Lettuce is an option for you, then from 4.0.Final MGET on cluster is supported:

The cluster API was extended to run a command on multiple nodes and invocation to multi-key commands DEL, MGET, MSET and MSETNX perform automatic pipelining if the keys belong to different slots/masters.

(Source: https://github.com/mp911de/lettuce/releases/tag/4.0.Final)


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Huntingtown High School is located at 4125 North Solomons Island Road, Huntingtown, Maryland (MD), United States. Completed and opened in 2004, HHS is currently home to approximately fifteen hundred students from grades 9 to 12. Huntingtown High School (HHS) is in Calvert County, and is part of the Calvert County Public Schools (CCPS).

Campus
The HHS campus features, aside from its building and traffic pattern: a football field, softball and baseball fields, a track, eight tennis courts and an assortment of practice fields and storm-water management ponds. The large, 3-story building is surrounded by these and two parking lots exiting onto Maryland Route 4. There is also a nature trail/cross country path which runs through the woods surrounding the building.

Academics
Huntingtown offers 21 Advanced Placement courses, as well as honors and standard classes.

Athletics
HHS hosts a variety of sports teams directed by VaShawne Gross. The Hurricanes compete in the Southern Maryland Athletic Conference (SMAC) and the 3A South Region of the Maryland Public Secondary Schools Athletic Association. Fall sports include football, boys' and girls' soccer, field hockey, cross country, golf, and volleyball. Winter sports include swimming, boys' and girls' basketball, indoor track, wrestling, and ice hockey. There are also cheer and dance teams for both the fall and winter. Spring sports include boys' and girls' lacrosse, softball, baseball, track and field, and tennis, and cheer.

Ice Hockey
Huntingtown established an ice hockey team in 2007.

Baseball
The Huntingtown baseball team is managed by Guy Smith Jr. Huntingtown has been to the State playoffs three times: in 2006, 2007, and 2010; they have reached the State finals three times: in 2006, 2010 and 2016. The Hurricanes have also been SMAC Champions five times: in 2007, 2009, 2010, 2011, and 2016. They won their first state title on May 30, 2016 defeating Chesapeake High School of Pasadena 4–3. This was also the first state champion won by a boys' team as well as the first baseball champion won by a high school in Calvert County. The team was led by future Major Leaguer, Alec "Hotstuff" Holtkamp.

Programs in the arts

Music
Huntingtown's Music Department is directed by Ms. Jessa Sablan (Band), Mrs. Sandra Griese (Chorus), and Mrs. Sara Moran (String Orchestra). The department sends several students yearly to Maryland All-State music programs, as well as various other honors ensembles.

Theatre
Huntingtown's Eye of the Storm Productions (EOTSP), under the direction of Mr. Derek Anderson, has been recognized by the American Alliance for High School Theatre as one of the top 35 High School Programs in the country. The company produces a fall play and spring musical, in addition to "Black Box" shows throughout the year.
The Eye of the Storms Productions is notable for producing famous musicals and plays, such as the successful The Phantom of the Opera and other musicals such as Footloose (musical). Along with musicals, EOTSP has produced plays such as A Midsummer Night's Dream. Huntingtown was one of the first high schools in the country to perform the musical In the Heights, which opened in the spring of 2013.

Journalism
The school's journalism program produces a news-magazine and yearbook annually.

Marching Band
The HHS Marching Hurricanes, directed by Ms. Jessa Sablan, is composed of students playing a wide range wind and percussion instruments as well as many Colorguard members. The Marching Hurricanes, composed of about 65 instrumentalists and guard members at the time.

Additional programs

Robotics
The HHS Robotics team was established in 2009, and has competed three times in local VEX Robotics Competitions.

Student Government Association
The HHS SGA is a member of the Calvert Association of Student Councils, the Maryland Association of Student Councils, and the National Association of Student Councils. It has won the MASC Felix Simon Award for outstanding SGA's and has hosted two state conferences. Every year, HHS SGA hosts homecoming along with other events, and sends multiple kids to both state and national conferences.

Humane Society Club
The Humane Society Club is for students interested in the protection of animals.

KEY Club
Key Club (Kiwanis Educating Youth) is a club devoted to giving back to the community and informing others of what they do as a club and a whole. They participate in numerous fundraising and awareness activities, such as: The Eliminate Project, Trick or Treat in the Garden at Anne Marie Gardens, The End Hunger Food Drive in Calvert County, and much more. The Huntingtown High School Key Club, while attending their District Convention in 2015, received numerous awards. These awards include: Outstanding President to Sydney President, Outstanding Vice President to Christy Nguyen, the Dale Q. Larson Faculty Outstanding Faculty Advisor to Ms. Rachel Dove, an Above and Outstanding Member Award to Elisabeth Cunningham, and First Place in the Club Video Contest.

Notable alumni

 Trevon Jenifer, member of the USA National Wheelchair Basketball Team

See also
List of high schools in Maryland

References

External links
 Huntingtown High School Website
 The Hurricane Nation Online Newspaper

Public high schools in Maryland
Schools in Calvert County, Maryland
Educational institutions established in 2004
2004 establishments in Maryland

redpajama_set_name: RedPajamaWikipedia


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Small town on Whidbey Island is becoming kissing capital of the Northwest
Thousands of people have locked lips under a Kissing Ball in Langley, Washington.
Author: Kim Holcomb
Published: 2:01 PM PDT October 10, 2018
LANGLEY, Wash. — Langley, Washington is less than one square mile with a population of 1,000 – but it's earning the title "Kissing Capital of the Northwest."
"Absolutely beyond a shadow of a doubt," said real estate agent Cheryl Keefe. "It's just all positive."
Keefe has a unique perspective on the PDA, because she sees it happening every day, outside her John L. Scott office on First Street.
Couples gather underneath a floral orb hanging from the awning, made by artist Elaine Michaelides.
"This is a kissing ball," Michaelides said. "It's a little bit like mistletoe, in that when you stand under it, this energy is just going to make you want to kiss."
It was originally hung as a holiday decoration, with people encouraged to record their kisses for posterity by making marks on a chalkboard.
But long after winter turned to spring, people still stopped to kiss.
So the ball remained and Keefe's office started keeping score.
"We tally the chalk marks up and we mark it down and we've just been keeping track ever since we started," she said.
After five years, the office has counted more than 13,000 kisses.
They've seen love in all its forms - from newlyweds to seasoned veterans, like a couple celebrating 50 years of marriage.
Mothers kissed their babies. Pet owners kissed their dogs.
"And then we've had people who kiss a whole lot. And we say, 'Maybe you should move on'…" Keefe said, laughing.
For all their differences, Keefe said the moments of joy have all shared one commonality.
"There's just maybe a second in time where they stop and they just focus on something that's probably the most important thing in the world," she said.
So the tally of affection continues to grow, in a small town that's tapped into something big.
"Oh, the world needs more love," Michaelides said. "That's for sure."
Evening celebrates the Northwest. Watch weeknights at 7:30 on KING 5 & streaming live on KING5.com. Contact: Facebook, Twitter, Instagram, Email.


Queensland's Labor state government is set to decriminalise abortion, in an effort to "bring Queensland into the 21st century," according to Premier Annastacia Palaszczuk.
Currently abortion is only legal in Queensland if the mother's mental or physical health is in serious risk.
The new laws will allow women to abort their babies up to 22 weeks, no questions asked. Doctors may refuse to perform abortions, but they must refer the patient to another practitioner. Also to be introduced is a 150-metre safe access zone around abortion clinics that could see pro-life protesters and sidewalk counsellors facing up to one year imprisonment, Attoney General Yvette D'Ath told 7 News Brisbane.
Here's Queensland Labor's plan: Abortion on demand. Abortion because the baby is a girl (or a boy) and the parent wanted different. Abortion at 40 weeks – late term and partial birth abortions included. Doctors will be de-registered for refusing to refer an abortion. And it's going to be illegal to hand out flyers – or even just pray as a silent protest – outside an abortion clinic. Welcome to Queensland. Beautiful one day, babyless the next.


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Danish Khan
Postdoctoral Scholar, Biochemistry
Danish is a postdoctoral research associate at the Brandman Lab at the Dept. of Biochemistry. His research focuses on understanding the mechanism of eukaryotic protein quality control pathways. Before joining Stanford, Danish earned his PhD from Texas A&M University, College Station, TX where he studied chemical inhibition of a lipid signaling protein and discovered a novel heme-binding lipid transfer protein. He also holds a Masters degree in Biotechnology from Banaras Hindu University in India, and a Bachelors degree from Presidency College, Kolkata (University of Calcutta), India. In addition to science, he likes to read about law and intersection of law and technology.
Dean's Fellowship, Stanford University (August, 2020)
Boards, Advisory Committees, Professional Organizations
Member, American Society for Biochemistry and Molecular Biology (2015 - Present)
Doctor of Philosophy, Texas A&M University College Station (2018)
Master of Science, Banaras Hindu University (2013)
Bachelor of Science, University Of Calcutta (2010)
Stanford Advisors
Onn Brandman, Postdoctoral Faculty Sponsor
Onn Brandman, Postdoctoral Research Mentor
ReporterSeq reveals genome-wide dynamic modulators of the heat shock response across diverse stressors. eLife Alford, B. D., Tassoni-Tsuchida, E., Khan, D., Work, J. J., Valiant, G., Brandman, O. 2021; 10
Understanding cellular stress response pathways is challenging because of the complexity of regulatory mechanisms and response dynamics, which can vary with both time and the type of stress. We developed a reverse genetic method called ReporterSeq to comprehensively identify genes regulating a stress-induced transcription factor under multiple conditions in a time-resolved manner. ReporterSeq links RNA-encoded barcode levels to pathway-specific output under genetic perturbations, allowing pooled pathway activity measurements via DNA sequencing alone and without cell enrichment or single-cell isolation. We used ReporterSeq to identify regulators of the heat shock response (HSR), a conserved, poorly understood transcriptional program that protects cells from proteotoxicity and is misregulated in disease. Genome-wide HSR regulation in budding yeast was assessed across 15 stress conditions, uncovering novel stress-specific, time-specific, and constitutive regulators. ReporterSeq can assess the genetic regulators of any transcriptional pathway with the scale of pooled genetic screens and the precision of pathway-specific readouts.
View details for DOI 10.7554/eLife.57376
Sis1 delivers the State of the Union. The Journal of cell biology Khan, D. n., Brandman, O. n. 2021; 220 (1)
The heat shock response (HSR) is a gene expression program that protects cells from heat and proteotoxic stressors. In this issue, Feder et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202005165) show that subcellular relocalization of the cochaperone Sis1 drives the HSR by de-suppressing the transcription factor Hsf1.
View details for DOI 10.1083/jcb.202011093
A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins ELIFE Khan, D., Lee, D., Gulten, G., Aggarwal, A., Wofford, J., Krieger, I., Tripathi, A., Patrick, J. W., Eckert, D. M., Laganowsky, A., Sacchettini, J., Lindahl, P., Bankaitis, V. A. 2020; 9
Yeast Sfh5 is an unusual member of the Sec14-like phosphatidylinositol transfer protein (PITP) family. Whereas PITPs are defined by their abilities to transfer phosphatidylinositol between membranes in vitro, and to stimulate phosphoinositide signaling in vivo, Sfh5 does not exhibit these activities. Rather, Sfh5 is a redox-active penta-coordinate high spin FeIII hemoprotein with an unusual heme-binding arrangement that involves a co-axial tyrosine/histidine coordination strategy and a complex electronic structure connecting the open shell iron d-orbitals with three aromatic ring systems. That Sfh5 is not a PITP is supported by demonstrations that heme is not a readily exchangeable ligand, and that phosphatidylinositol-exchange activity is resuscitated in heme binding-deficient Sfh5 mutants. The collective data identify Sfh5 as the prototype of a new class of fungal hemoproteins, and emphasize the versatility of the Sec14-fold as scaffold for translating the binding of chemically distinct ligands to the control of diverse sets of cellular activities.
View details for PubMedCentralID PMC7462610
Biophysical Parameters of the Sec14 Phospholipid Exchange Cycle BIOPHYSICAL JOURNAL Sugiura, T., Takahashi, C., Chuma, Y., Fukuda, M., Yamada, M., Yoshida, U., Nakao, H., Ikeda, K., Khan, D., Nile, A. H., Bankaitis, V. A., Nakano, M. 2019; 116 (1): 92–103
Sec14, the major yeast phosphatidylcholine (PC)/phosphatidylinositol (PI) transfer protein (PITP), coordinates PC and PI metabolism to facilitate an appropriate and essential lipid signaling environment for membrane trafficking from trans-Golgi membranes. The Sec14 PI/PC exchange cycle is essential for its essential biological activity, but fundamental aspects of how this PITP executes its lipid transfer cycle remain unknown. To address some of these outstanding issues, we applied time-resolved small-angle neutron scattering for the determination of protein-mediated intervesicular movement of deuterated and hydrogenated phospholipids in vitro. Quantitative analysis by small-angle neutron scattering revealed that Sec14 PI- and PC-exchange activities were sensitive to both the lipid composition and curvature of membranes. Moreover, we report that these two parameters regulate lipid exchange activity via distinct mechanisms. Increased membrane curvature promoted both membrane binding and lipid exchange properties of Sec14, indicating that this PITP preferentially acts on the membrane site with a convexly curved face. This biophysical property likely constitutes part of a mechanism by which spatial specificity of Sec14 function is determined in cells. Finally, wild-type Sec14, but not a mixture of Sec14 proteins specifically deficient in either PC- or PI-binding activity, was able to effect a net transfer of PI or PC down opposing concentration gradients in vitro.
View details for DOI 10.1016/j.bpj.2018.11.3131
Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties CELL CHEMICAL BIOLOGY Pries, V., Noecker, C., Khan, D., Johnen, P., Hong, Z., Tripathi, A., Keller, A., Fitz, M., Perruccio, F., Filipuzzi, I., Thavam, S., Aust, T., Riedl, R., Ziegler, S., Bono, F., Schaaf, G., Bankaitis, V. A., Waldmann, H., Hoepfner, D. 2018; 25 (3): 279-+
Invasive fungal infections are accompanied by high mortality rates that range up to 90%. At present, only three different compound classes are available for use in the clinic, and these often suffer from low bioavailability, toxicity, and drug resistance. These issues emphasize an urgent need for novel antifungal agents. Herein, we report the identification of chemically versatile benzamide and picolinamide scaffolds with antifungal properties. Chemogenomic profiling and biochemical assays with purified protein identified Sec14p, the major phosphatidylinositol/phosphatidylcholine transfer protein in Saccharomyces cerevisiae, as the sole essential target for these compounds. A functional variomics screen identified resistance-conferring residues that localized to the lipid-binding pocket of Sec14p. Determination of the X-ray co-crystal structure of a Sec14p-compound complex confirmed binding in this cavity and rationalized both the resistance-conferring residues and the observed structure-activity relationships. Taken together, these findings open new avenues for rational compound optimization and development of novel antifungal agents.
View details for DOI 10.1016/j.chembiol.2017.12.007
Structural elements that govern Sec14-like PITP sensitivities to potent small molecule inhibitors JOURNAL OF LIPID RESEARCH Khan, D., McGrath, K. R., Dorosheva, O., Bankaitis, V. A., Tripathi, A. 2016; 57 (4): 650–62
Sec14-like phosphatidylinositol transfer proteins (PITPs) play important biological functions in integrating multiple aspects of intracellular lipid metabolism with phosphatidylinositol-4-phosphate signaling. As such, these proteins offer new opportunities for highly selective chemical interference with specific phosphoinositide pathways in cells. The first and best characterized small molecule inhibitors of the yeast PITP, Sec14, are nitrophenyl(4-(2-methoxyphenyl)piperazin-1-yl)methanones (NPPMs), and a hallmark feature of NPPMs is their exquisite targeting specificities for Sec14 relative to other closely related Sec14-like PITPs. Our present understanding of Sec14::NPPM binding interactions is based on computational docking and rational loss-of-function approaches. While those approaches have been informative, we still lack an adequate understanding of the basis for the high selectivity of NPPMs among closely related Sec14-like PITPs. Herein, we describe a Sec14 motif, which we term the VV signature, that contributes significantly to the NPPM sensitivity/resistance of Sec14-like phosphatidylinositol (PtdIns)/phosphatidylcholine (PtdCho) transfer proteins. The data not only reveal previously unappreciated determinants that govern Sec14-like PITP sensitivities to NPPMs, but enable predictions of which Sec14-like PtdIns/PtdCho transfer proteins are likely to be NPPM resistant or sensitive based on primary sequence considerations. Finally, the data provide independent evidence in support of previous studies highlighting the importance of Sec14 residue Ser173 in the mechanism by which NPPMs engage and inhibit Sec14-like PITPs.
View details for DOI 10.1194/jlr.M066381
Phosphatidylinositol transfer proteins and instructive regulation of lipid kinase biology BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS Grabon, A., Khan, D., Bankaitis, V. A. 2015; 1851 (6): 724–35
Phosphatidylinositol is a metabolic precursor of phosphoinositides and soluble inositol phosphates. Both sets of molecules represent versatile intracellular chemical signals in eukaryotes. While much effort has been invested in understanding the enzymes that produce and consume these molecules, central aspects for how phosphoinositide production is controlled and functionally partitioned remain unresolved and largely unappreciated. It is in this regard that phosphatidylinositol (PtdIns) transfer proteins (PITPs) are emerging as central regulators of the functional channeling of phosphoinositide pools produced on demand for specific signaling purposes. The physiological significance of these proteins is amply demonstrated by the consequences that accompany deficits in individual PITPs. Although the biological problem is fascinating, and of direct relevance to disease, PITPs remain largely uncharacterized. Herein, we discuss our perspectives regarding what is known about how PITPs work as molecules, and highlight progress in our understanding of how PITPs are integrated into cellular physiology. This article is part of a Special Issue entitled Phosphoinositides.
View details for DOI 10.1016/j.bbalip.2014.12.011


Rather than aspiring for purely personal growth in 2015, consider the impact that a new business resolution will have on your work-life balance so you can achieve truly satisfying success in the New Year.
The start of the New Year is a great time to reflect on your business's progress in the preceding year, and also to develop and implement your forthcoming strategy to build on last year's successes. Instead of continuing to do the same things the same way to get the same results, it is now quite the opposite in a lot of fast-paced industries. There comes a time when you need to invest in something new to move your business forward.
Should I Invest in the Cloud?
Any investment is a big decision. It is important to therefore establish what the technology will add to your business. How many stages will the new technology remove from your existing processes? How much faster will that allow you to deliver to your prospects and customers? How superior will your product or service be as a result? And how much of an advantage will these elements give you over your competitors?
Most industries face continuous challenges from procurement teams to deliver year-on-year cost savings, and from sales leaders to bring in more revenue faster. Doing more with less. This can only be realised by obtaining new means of doing things, and cloud technology has a significant role to play in delivering on these objectives.
Cloud technology gives your business the flexibility and mobility it never had before to react swiftly to opportunities, implement new applications, and scale up quickly to meet increasing consumer demand. Simultaneously, it can considerably lower the costs of hardware, upkeep, and IT staffing. For almost every organisation, some form of cloud technology simply makes sense, which leads on to the most important question: can you afford not to invest?
Whether it's getting rid of an old fax machine that's a pain to use or enabling contracts to be signed faster, reducing operating costs or eliminating paper, make a New Year's resolution to invest in what you and your business need.
It's no secret that in order for your business to survive, you need to keep up with change. If, instead, you want your business to flourish, you're probably going to have to lead that change. Investing in new technology will provide your business with the platform and the mobility to ensure your customers choose you over your competitors.
To find out more, join one of our upcoming webinars and discover how the cloud can help your business thrive in 2015.


On Monday, Piper Jaffray appear "Taking Stock With Teens," its semiannual analysis of boyhood spending habits. The address showed that adolescence are spending added on aliment and video amateur than on annihilation abroad but are continuing to drive advance in able-bodied wear.
The '90s logo and streetwear chic hasn't faded. Tommy Hilfiger, Supreme, Calvin Klein, and Champion abide to acceleration in acceptance amid these adolescent shoppers.


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⭐ What country first discovered australia?
What country first discovered australia?
Asked By: Lindsey Kohler
Date created: Mon, Jun 14, 2021 12:16 AM
Date updated: Fri, Jan 28, 2022 2:56 AM
FAQ. Those who are looking for an answer to the question «What country first discovered australia?» often ask the following questions
Those who are looking for an answer to the question «What country first discovered australia?» often ask the following questions:
⭐ Who first discovered australia?
While Indigenous Australians have inhabited the continent for tens of thousands of years, and traded with nearby islanders, the first documented landing on Australia by a European was in 1606. The Dutch explorer Willem Janszoon landed on the western side of Cape York Peninsula and charted about 300 km of coastline.
When was mdma first discovered in australia?
What european country first settled australia?
What ship discovered australia?
⭐ When was australia first discovered?
When was gold first discovered in south australia?
Where was geothermal energy first discovered in australia?
When was the inland taipan first discovered in australia?
⭐ Who really discovered australia first?
Who discovered sydney australia?
When and where was gold first discovered in south australia?
When did australia first become a country?
Answered by Cornelius Koepp on Mon, Jun 14, 2021 11:38 AM
Traders from Portugal are believed to have been the first to sight the Australian continent.The Dutch (natives of Holland) were the first recordedEuropeans to explore Australia.See also the related question.
We've handpicked 21 related questions for you, similar to «What country first discovered australia?» so you can surely find the answer!
When was australia first consided a country?
What are now the states of Australia existed as separate British Colonies until they federated to form the nation of Australia on 1 Jan 1901.
What country was the first to migrate to australia?
No country ever migrated to Australia. All countries have stayed exactly where they are. Only the people of a country can migrate.Officially, it was the the people of Great Britain who were the first to migrate.In reality, the first migrants were the indigenous people who 'migrated', coming from the Indian subcontinent.
Who discovered australia in 1770?
James Cook was the first recorded explorer to land on the east coast in 1770. He had with him maps showing the north, west and south coasts based on the earlier Dutch exploration.
Who discovered dingoes in australia?
Nobody really noes the true way the dingoes came to be in Australia the are just theorys
What was discovered in australia in 1851?
Australia's first payable gold was officially discovered in Australia in May 1851.
Which country was the first to control australia?
Great Britain first "controlled" Australia. Great Britain made the first official claim to the continent, and it also established the first permanent settlement.
Who first discovered the sydney opera house?
Captian Cook and his truty guide Benelong.
What did dirk hartog call australia when discovered?
Because Dirk Hartog was Dutch, the western half of the Australian continent was called "New Holland".
What if gold was never discovered in australia?
life would be bad not much gold rushes too
What was australia called before it was discovered?
After British colonisation, the name New Holland was retained for several decades and the south polar continent continued to be called Terra Australis, sometimes shortened to Australia. How was gold discovered in australia?
History of discovery. The first gold rush in Australia began in May 1851 after prospector Edward Hargraves claimed to have discovered payable gold near Orange, at a site he called Ophir . Hargraves had been to the Californian goldfields and had learned new gold prospecting techniques such as panning and cradling.
Which south american explorer discovered australia?
No South American explorer discovered Australia.To see who really discovered Australia, see the related question below.
Who discovered australia and new zealand?
Abel Tasman was a great explorer who discovered Australia and New Zealand long before James Cook. Discover what he did in his Australasian Adventures.
Who discovered australia before european settlement?
The aboriginals because they walked from Asia across Landbridges and discovered Australia.
Captain Cook did not discover Australia. See the related question.As for who travelled with Cook: apart from the usual ship's crew, Captain Cook also had the botanist Sir Joseph Banks with him. Banks classified and named many new species of plants in Australia and New Zealand, and the unique Australian species known as the banksia is named after him. The Swedish botanist Daniel Solander and Finnish scientist Dr. Herman Spöring also travelled with Cook, being employed by Joseph Banks.At Tahiti, Cook was also joined on his voyage by a Tahitian chief named Tupaia, who wanted to travel, together with his boy-servant Tayeto.
Who discovered botany bay in australia?
captainJames cook discoverd botany bay in Australia
Who discovered gold in south australia?
Gold was found in January 1846 by Captain Thomas Terrell at the Victoria Mine near Castambul, in the Adelaide Hills, South Australia, about 10 miles (16 km) east of Adelaide. Some of the gold was made into a brooch sent to Queen Victoria and samples were displayed at the Great Exhibition at the Crystal Palace in 1851.
What country inhabited australia?
Australia was originally colonised by Great Britain.
What country owns australia?
Country by country, the UK is the biggest foreign investor in Australian farmland, owning 10.2 million hectares, followed by China with 9.2 million and then, each owning two or more million hectares, the US, the Netherlands, the Bahamas and Canada.
Why did edward hargraves who discovered gold in bathurst first come to australia?
Edward Hargraves's family had immigrated to Australia from England, so he lived in Australia for awhile, attempting to find a job. He was lured to the Californian goldfields to try and make his fortune during the gold rush there. He was unsuccessful, despite spending some 12 months prospecting, so took his new knowledge of gold-bearing country back to Australia. He recalled similarities between California's soil conditions and those in parts of Australia: thus, with the help of some local knowledge, he was able to find gold.
What country in australia was first said to be in drought?
There are no other countries in Australia. Australia is the only country in Australia. Droughts have been known here since the start of European settlement, so it is most likely that the first known drought to affect European settlers occurred within New South Wales, the first state to be settled.


Very soon after introducing T³Alliance it's time to set the tone for the entire program with the introductory lesson on growth and fixed mindsets. As outlined in the video above, this fits into three components: 1. Teaching about growth mindset; 2 Set the tone with an ice breaker; and 3. Build a robot with a brushbot.
Here is the link to the presentation referenced above. The easiest way to get students on the same page is to share the Carol Dweck RSA Animate video. The video will introduce the importance of how we speak to each other about our work.
You may want to look for some materials for an ice breaker. These can be short pieces of rope that can be used to start off the program in the Infinite Loop Handcuff Solution: https://youtu.be/aiNl-EL6vfk.
We believe in allowing curiosity, exploration and PLAY to happen. It means kids have to feel safe to explore and have fun, even in the midst of failures.
The term we now use is "neuroplasticity" to change the way our brains think.
Imagine your brain is like a forest. You could potentially make a walking path anywhere, but ahead of you is the road most often followed. The ground on this path is smooth and compacted, the brush has been cleared.
It's easy to walk on, especially since you've walked it hundreds of thousands of times before. You walk on it automatically, unconscious of the decision to move in its direction rather than go, or be, another way.
If you want to change a belief or a habit or a physical sensation or negative self-talk, you must create a new path. You need to take a road less traveled.
You'll need a machete to clear away the brush and branches. You'll probably get scratched by spiky plants and twigs along the way. It will be hard.
It's easy to slip back into old ways of being.
That's why most of all, it's absolutely necessary to walk on this new path over and over and over again until the ground is smooth and compacted, until the old path has for grown over and the forest has reclaimed that space with a density of plants. Now the easy path is the one you created, consciously and with a healing intent.
Here's a 5-minute video about Growth Mindset vs. Fixed Mindset.
Remind students that it's only through failure that we gain our greatest knowledge.
Congratulations on taking the first step towards your students learning all they can and not limiting themselves or others. Changing from a "fixed" to a "growth" mindset is not easy. We often revert back to what we know when under stress. Encourage your students to keep this in mind as you continue to reinforce positive feedback.
Posted in Curriculum, Growth Mindset, Materials, Resources, Uncategorized.
Khan Academy now also has resources and lesson plans for Growth Mindset.


The viral trend, which started late last week, involves people using various food emojis to indicate what their stomach is filled with.
It's impossible to predict what the next viral meme template will be, which might explain why the latest obsession on Twitter is the 'flat stomach' meme which is used to let others know why you don't have a flat stomach. Or even, what exactly are the contents of your stomach.
It reportedly gained momentum after Twitter user @itsJWolfe tweeted emojis of all the delicious things he'd eaten. Who needs a flat stomach when you can fill your body with steaks, french fries and cheese, right?
So, after the 'really really really' meme, Twitter users across the platform are using the meme template not just to talk about food but pregnancy and other matters as well.
Here are a few tweets on the meme going viral.
my friend's mum: are you hungry!?
What emojis would you use?


text:
Alfred Hermida Livestream
Posted In News - By Axel Bruns On Friday, November 29th, 2013 With 0 Comments
Update 10 December: The archive recording of Alfred Hermida's guest lecture is now available below (DW)
As we've previously announced, the QUT Social Media Research Group and the Journalism, Media & Communication Discipline in the Creative Industries Faculty at QUT are delighted to host a special guest lecture by internationally renowned journalism scholar Alfred Hermida today. We'll also try to livestream the talk, from 12 noon Brisbane time (UTC+10 – that's 1 p.m. for our less fortunate cousins in the southern states of Australia). Please tune in then – and apologies in advance if the livestream should drop out at some point (it's an experiment).
Hashtag Dissent: #Idlenomore Aboriginal Counter Narratives on Twitter
A growing body of research points to how social media, and specifically Twitter, is emerging as a hybrid space for the cultural production of journalism, with citizens are involved in the flow, framing and interpretation of news. Studies into recent social movements such as Occupy Wall Street indicate how committed individuals are appropriating social media as one of the tools to articulate a counter narrative, and contest dismissive framing by mainstream media. One such movement is Idle No More. This presentation will discuss how activists in Canada mobilised around the #Idlenomore hashtag and used Twitter to advance their message of dissent. What started as an Aboriginal protest in December 2012 developed into a loosely knit political movement. Twitter served as an alternative platform of public communication that facilitated the visibility of a marginalised social reality. The research provides insights into how engagement with networked technologies by people outside news organisations neutralise, challenge or reinforce the power of media institutions to construct social reality and how it reconfigures journalism's role to foster a broadly informed and engaged public.
Prof Alfred Hermida is an award-winning British online news pioneer, digital media scholar and journalism educator. An associate professor at the Graduate School of Journalism, University of British Columbia, Vancouver, Canada, his research on the intersection of communication technologies, journalism and the networked society has been published in Journalism Studies, Journalism Practice and the Journal of Broadcasting and Electronic Media. He is co-author of Participatory Journalism: Guarding Open Gates at Online Newspapers (Wiley-Blackwell, 2011), and is working on his new book, Tell Everyone: How the Stories We Share Shape What We Know and Why It Matters, due to be published by Doubleday Canada. Prof Hermida is a 16-year veteran of the BBC and was a founding news editor of the BBC News website in 1997.
Tags: #idlenomore, Alfred Hermida, dissent, guest lecture, journalism, social media, Twitter
Axel Bruns - Axel Bruns is a Professor in the Digital Media Research Centre at Queensland University of Technology in Brisbane, Australia, where he leads the Digital Publics programme.
More 'Fake News' Research, and a PhD Opportunity!
'Like a Virus' – Disinformation in the Age of COVID-19
(Re-) Introducing the Australian Twitter News Index
Some Questions about Filter Bubbles, Polarisation, and the APIcalypse


The legendary actor Harrison Ford spent some quality time in Connecticut and was snapped in the kitchen with the staff at O'Rourke's Diner in Middletown, yesterday.
It turns out he like so many Middletown residents is a fan of the restaurant's famed steamed cheeseburger, which he tried while dining with his wife, actress Calista Flockhart and their son Liam. Calista sampled the diner's veggie burger.
It was an early lunch visit which centered around the family's tour of Wesleyan University, in Middletown Connecticut, which may be Liam's college destination in the near future.
O'Rourke's Diner is on the nation's radar for beng a great eatery and is frequented by foodies and celebrities alike, so it makes sense that Harrison and family would make a stop there. In fact, O'Rourke's was one of the few CT spots featured on the Food Network's "Diners, Drive-Ins, and Dives."
It's nice to know people even of [Ford's] status can take the time to shake some hands and take selfies with people.


Lexie Moffitt, a Fletcher teen, died Monday after losing control of her car and striking a pickup truck.
A Fletcher teen died in a head-on collision Monday after she lost control of her car and crossed into oncoming traffic, state troopers say.
Alexis Moffitt, 17, who goes by Lexie on her Facebook page, died at the scene of two-vehicle wreck, which happened about 1:40 p.m. on Christ School Road. Troopers say Moffitt was traveling east when she lost control of her 2008 Honda Civic, crossed the centerline and struck a Chevy pickup.
Moffitt was a senior at West Henderson High School and had attended North Henderson High in the past.
The driver of the truck was injured in the collision and was transported to the hospital for treatment, according to State Trooper Rico Stephens. The truck's driver also is a Fletcher resident.
It was raining at the time of the wreck, and troopers have determined that Moffitt was traveling too fast for conditions.
Henderson County Public Schools released a statement about Moffitt, saying the schools' "family is deeply saddened by the loss of Lexie Moffitt, a senior at West Henderson High."
The release also noted that Moffitt's father and stepmother, Jesse and Erin Moffitt, "wish to share their thanks with the community for the sympathy they've received.
Lexie Moffitt had worked as a cashier at the Ingles in Fletcher since her 16th birthday, store Manager Greg Jackson said, adding that she'd recently moved into the in-store Starbucks coffee shop. She regularly worked 10-20 hours a week and planned on going to college.
"She just had a real bubbly personality and a beautiful smile," Jackson said. "Her presence was always known because she was always just so outgoing."
The Moffitt family is well-known in Fletcher, Jackson said, noting that he's been friends with Moffitt's grandfather, Chris Moffitt, for 36 years. News of Lexie's death spread throughout Fletcher, a small town in Henderson County on the border with Buncombe.
"Our store is grieving as well," Jackson said. "We really want the emphasis put on how much her family is in our thoughts and prayers. Such a young life…"
The school system stated that school psychologists and school counselors with the district's Crisis Team are at West Henderson High on Tuesday to talk with students and staff and provide support.


In the RGB color model, hex triplet #458868 has decimal index of: 4556904, is composed of 27.1% red, 53.3% green and 40.8% blue. #458868 in CMYK color model, is composed of 49.3% cyan, 0% magenta, 23.5% yellow and 46.7% black.
#339966 is the closest web-safe color to #458868.
Sample HTML/CSS paragraph codes using #458868 color.


How do you clean the cooking grate on a grill?
You are here: Home / Foods and Drinks / How do you clean the cooking grate on a grill?
I have a charcoal grill, and the cooking grate needs to be cleaned. What's the best way to clean it?
Replies to : How do you clean the cooking grate on a grill?
Oven cleaner! Spray it on, let it soak in…..grime comes right off. Have fun!
Personally, I cleanse with fire! I then brush off the charred remains with a brass grill brush. This has worked much better that trying to use chemicals or spending much time trying to scour it clean.


text:
package com.ilivoo.hibernate.learning.component.id.xml;

import java.io.Serializable;

public class Person2 implements Serializable{
	private static final long serialVersionUID = -7544095937347187638L;

	private Name name;

	private int age;

	public Name getName() {
		return name;
	}

	public void setName(Name name) {
		this.name = name;
	}

	public int getAge() {
		return age;
	}

	public void setAge(int age) {
		this.age = age;
	}
}

redpajama_set_name: RedPajamaGithub


WASHINGTON (CN) – Looking past the no-shows whose absence riled up House Republicans at a hearing on the death of a federal agent in Mexico, Democrats argued Thursday that the crux of the tragedy lies with budget cuts and deregulation.
The 2011 death of immigration agent Jaime Zapata is not directly tied to the Fast and Furious boondoggle out of the Bureau of Alcohol, Tobacco, Firearms and Explosives, but it bears many of the same missteps and errors that ended in an unprecedented contempt finding against then-Attorney General Eric Holder after a years-long investigation.
The ATF's Phoenix, Arizona, field division dreamed up Operation Fast and Furious as way to bring down the leaders of Mexican cartels by letting their straw buyers purchase guns from licensed firearms dealers in the United States.
Agents ultimately recovered only hundreds of the thousands of guns at issue, and two such rifles turned up at the 2010 murder scene of Border Patrol agent Brian Terry.
Though Zapata was also killed with a gun trafficked from the United States, the Dallas-Fort Worth area of Texas where the gun was sold fell outside the Phoenix ATF's purview.
The House Oversight and Government Reform Committee convened a hearing this morning to study the report, but only ATF Acting Director Thomas Brandon showed up to testify.
Committee chairman Jason Chaffetz slammed the excuses Brandon offered for why two of his colleagues, ATF Associate Deputy Director and CEO Ronald Turk and Special Agent in Charge William Temple, sat out the hearing.
"The idea that you needed more time, that you didn't get the customary two weeks is a load of crap and you know it," said Chaffetz, a Utah Republican.
"You had this since December," Chaffetz said of the report.
Chaffetz said the officials likely knew they'd be asked about the report long before its official March release. Subpoenas that Chaffetz issued this morning will force Turk and Temple to give a deposition to the committee later this month.
The OIG's report offers key details on Manuel Barba, the head of the ring of "straw purchasers" who moved one of the guns that was used to kill Zapata to Mexico.
Barba had been in federal custody, the report says, but he was released after the Drug Enforcement Agency failed to share the details of his possible involvement in a gun-trafficking scheme with the ATF and a federal prosecutor.
The ATF also failed to act on information that would have allowed it to arrest two other people involved in running guns to Mexico, according to the report.
"We'll never know whether agent Zapata would still be alive if the ATF had done its job properly, and we rely heavily on the inspector general and their expertise in looking at this," Chaffetz said at Thursday's hearing.
Brandon testified that the ATF has taken steps to move past the scandal. "ATF of 2017 is not the ATF of 2010 when much of this stuff happened," Brandon said.
Inspector General Michael Horowitz supported this claim in his own testimony.


text:
Q: In Python, write a program that asks the user to type in four numbers and puts all of them in a list called lst I've written a program that asks the user to type in four numbers like this:
a = input()
first = int(a)
b = input()
second = int(b)
c = input()
third = int(c)
d = input()
fourth = int(d)

I do not understand how can I put them in a list.

A: You should improve your code a little bit:
first = int(input())
second = int(input())
third = int(input())
fourth = int(input())
lst = [first, second, third, fourth]

A: Note that you could use list-comprehension:
lst = [int (input ()) for time in range (4)]

This uses a simple for loop to execute int (input ()) 4 times. Now you could just access the inputs by using lst [0], lst [1], 'lst [2], and lst [3].

A: First off, you can put your code in a code block by using an empty line and then indenting 4 spaces.
You can put your variables in a list like this:
list_variables = [first, second, third, fourth]

A: option one :
lst = [first, second, third, fourth]

option two :
lst = []
lst.append(first)
lst.append(second)
lst.append(third)
lst.append(fourth)

A: One more approach is to ask input numbers separated by space and then split them
numbers = input()
numbers_list = numbers.split(' ')
int_numbers_list = map(int, numbers_list)

Possible raise error if count of numbers not equal 4
while True:
    numbers = input()
    numbers_list = numbers.split(' ')
    if len(numbers_list) != 4:
        print('Enter numbers again')
        continue
    int_numbers_list = map(int, numbers_list)
    break

A: Here is a 1-liner but does not take care of the 4 input restriction (in case you need):
lst = list(map(int, input().split()))

'''
3 4 5 6
[3, 4, 5, 6]
'''


text:
Q: Reschedule meeting due to the unavailability of one participant I'd like to reschedule the meeting due to the unavailability of one of the participants. He's an important element for the meeting. I am looking for a sample e-mail to inform all participants that the meeting will be postponed by two hours.

A: Postpone is certainly the right word.

Because X is unavailable, the meeting has been postponed two hours.

You could be more specific about the date and time of the meeting.

Because X is unavailable, the meeting has been postponed until July
16, 2020 at 5:00 p.m.

I like BoldBen's suggestion:

Because X is unavailable, the meeting scheduled for 3:00 p.m. on July 16, 2020 has been
postponed until 5:00 p.m. on the same day.


2019 may have officially arrived, but that didn't stop Secret Foodies from stepping back in time to the fabulous fifties.
A new year means another exciting line up of events curated by the Secret Foodies team. To kickstart 2019, we took a trip back in time to the fabulous fifties, where the lights were low and the music sweet.
Guests channeled their inner Don and Betty Draper as they headed into the big smoke for a fifties inspired soiree. Bopp & Tone, the latest Applejack Hospitality venue, was revealed as the secret destination for the evening.
Replacing the old Steel Bar site, the new CBD venue is a tribute to Applejack founders' grandfathers, Keith 'Bopp' Evans and Anthony 'Tone' Adams. The venue reflects the nostalgic and optimistic post WW2 era they lived in, embodying every day opulence and grandeur.
Secret Foodies guests arrived in their finest 50s-inspired attire, before mingling in the outdoor terrace for a round of cocktails and Sydney rock oysters. The concoction on offer, a refreshing Four Pillars Lemon Myrtle Collins.
Ms Darlinghurst, aka Alex Adams, soon lured guests inside to the main dining room. Visually striking, the space came complete with plush velvet booths, warm timber furnishings and low lighting. A three-piece band, The Swinging Gypsies, added a lively flourish, as guests settled into the their seats for the evening.
Designed to share, the first wave of plates were quick to hit the tables.
Cobia kingfish crudo and ruby grapefruit came with a generous drizzling of extra virgin olive oil, while the baked mozzarella in lemon leaves and chilli oil was decadent and delicious.
Sparkling Cupio rosé made for an ideal accompaniment to these dishes, quickly setting the standard for the evening ahead. Lively jazz tunes encouraged foodies to get up and dance the jive, giving them time to make room for the imminent courses.
Before long, guests were treated to Mooloolaba prawns, cooked in a fragrant sauce of chilli, garlic, oregano, olive oil and lemon. To match this seafood dish, glasses were soon filled with a light Mud House Pinot Gris 2017.
Spatchcock arrived to the tables soon after, its smoky flavour accentuated by a moorish paprika, oregano and chilli yoghurt. Succulent and flavoursome, it quickly became a crowd favourite amongst the Secret Foodies guests. To cut through the richness, a salad of buffalo ricotta, white peaches and smoked almonds was served.
The food odyssey continued with grass fed Brooklyn Valley rib eye steak. Cooked medium rare, it was teamed with an assortment of simple sides including charred broccolini and roasted potatoes in herb butter. Steak and red wine are nothing short of a perfect match, and sure enough to accompany this next course, guests were treated to the Batch X Sangiovese.
With stomachs full to bursting, Alex brought Head Chef Sa up before the crowd. He spoke eagerly of his passion for cooking, how he came to Bopp & Tone, and of the seasonally driven menu.
Soon it was time for the final dish of the evening – dessert! To cap off a decadent meal, chocolate and passionfruit mud cake arrived to the table. Topped with a texture rich buckwheat crumb, the dish reflected the elegance and precision encapsulating the venue.
Special thanks must go to the hard working team at Bopp & Tone for making the first Secret Foodies event of 2019 possible.
We would also like to thank Cupio Wines, Mud House Wines and Four Pillars for supplying the drinks on the day.
Bopp & Tone is open Monday & Tuesday 11:30am-11:00pm, Wednesday & Thursday 11:30am-12:00am, Friday & Saturday 11:30am-1am, Sunday Closed.
Secret Foodies is a surprise dining experience for those with a taste for adventure. Our unique events are designed to suit people who love great food, meeting new people and discovering new places.


text:
Le menhir del Roc del Frare ou Pedra dreta d'Agullana est un menhir situé sur le territoire de la commune d'Agullana, dans la province de Gérone, en Catalogne.

Situation

Le menhir del Roc del Frare est situé au sud du village d'Agullana, dans les environs du mas de can Geli del Bosc, en direction du mas Genís.

Description

Le menhir del Roc del Frare mesure  de haut,  de large et  d'épaisseur. Constitué de granite, il est orienté vers le sud-ouest, comme le sont deux autres dolmens situés sur le territoire d'Agullana, la Barraca del Lladre et la Jaça d'en Torrent.

Voir aussi

Articles connexes
 Liste des sites mégalithiques de l'Alt Empordà
 Liste des sites mégalithiques en Catalogne

Liens externes
  Le menhir del Roc del Frare sur le site de la mairie d'Agullana.

Notes et références

Agullana
Roc del Frare


text:
Q: Input from one page into another page using jquery I need to send a parameter from a link to another page that has a text field that calls a .php script and displays information related to the string entered. But if I reach this page passing the parameter by a URL instead of typing it in the text field of the page, the php returns only the json code to the screen. I need to bypass the text field from this url I am trying to build some how. I am trying to do this using ajax, but no success. Any suggestion?
JavaScript:
$(function(){
  $("#textto").keyup(function(){
    var txt = $("#go").attr( $(this).val() );
    $.ajax({
      url: './new_page.php',
      data: {
        'searching' : txt,
        'pam' : 'name',
      },
      success: function(data) {
        alert(data);
      }
    });
  });
});

HTML:
<input type="text" value="" id="texto"/>
Another Page

A: The easiest thing is to let a form do it for you, you don't even need js for this:

<form method="get" action="new_page.php">
  <input type="text" name="searching" value=""/>
  <input type="hidden" name="pam" value="name"/>
  <input type="submit" value="Another Page"/>
</form>


Generic Green Revox PR99, B77, C270 1/4" tape recorder universal pinch roller kit. Non OEM.
European made new GREEN pinch roller using a modern Adiprene formulation. It is much more stable than original and wont go gooey.
Shim / washer kit - 1 x PTFE and 1 x Metal shims to suit B77, PR99, C270.
The green pinch roller is specified for most B77, A700, C270 etc. The shims and washers allow it to be installed in most Revox tape machines B77, PR99 and C270 and align the pinch roller optimally.