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In the same year, Microsoft announced the SPOT smartwatch and it began hitting stores in early 2004.[30] SPOT stands for Smart Personal Objects Technology, an initiative by Microsoft to personalize household electronics and other everyday gadgets. For instance, the company demonstrated coffee makers, weather stations, and alarm clocks featuring built-in SPOT technology.[31] The device was a standalone smartwatch[32] that offered information at a glance where other devices would have required more immersion and interaction. The information included weather, news, stock prices, and sports scores and was transmitted through FM waves.[30] It was accessible through a yearly subscription that cost from $39 to $59.[31]
If you'd prefer your smartwatch looked more like a piece of jewelry than a small computer on your wrist, you'll like Skagen's Falster range. The straps of these slimline watches come in a few different leather or stainless steel options but coupled with the included minimalist watch face designs, they all look sleek and stylish in a way few other smartwatches manage.
Yes, it can monitor your health and fitness. You should choose one that has a pedometer to count your steps. An accelerometer is helpful in determining acceleration. Acceleration can be used to detect when you fall. A heart rate sensor can be used to monitor your heart beats. Some will report the amount of calories you consume and even display a report of your health at day's end.
If you wear the Q Explorist close to your hand, its case size and protruding center button can activate when you bend your wrist back, or if you're wearing thicker gloves. The worst that happens is that Google Assistant is activated, and it either does nothing or tries to ask Google whatever nonsense the microphone picks up inadvertently. That can be annoying, and may cause you to size your watch band a bit larger, so the watch sits up your arm a bit more, clear of your wrist joint. Sadly, Wear OS lacks a "left-handed mode" to allow for turning the watch and its gestures the other direction.
If you want the app, notification, and style advantages of an Apple Watch but need better fitness tracking, you can upgrade to the Apple Watch Series 3 and get built-in GPS, as well as waterproofing that allows swim tracking. But the Series 3 costs more than a fitness tracker or even many running watches, and it still has compromises compared with a dedicated fitness tracker, such as a lack of dedicated physical buttons. We think serious athletes are better served by a fitness-specific device.
On-Screen Workouts/ Connected GPS/ Bluetooth/ Smartphone Notifications/ 4 Day Battery Life/ Heart Rate Tracking/ 15 Exercise Modes/ SmartTrack/ All-Day Activity/ Female Health/ Sleep Tracking And Stages/ Cardio Fitness Level/ 3-Axis Accelerometer And Gyroscope/ Optical Heart Rate Monitor/ Color LCD Touchscreen Display/ Water Resistant To 50 Meters/ Charcoal Woven Strap & Graphite Aluminum Finish
What's on display?: Most smartwatches have full-colour displays, though the underlying technology will determine how good the screen looks. There has been a move towards AMOLED (active matrix organic light emitting diode) displays, as used in the Apple Watch which present a bright screen, crisp text and accurate colours. Fitness trackers tend to have lower-quality screens and may not present in full-colour, partly to save battery life.
Unfortunately, you won't be able to respond to alerts (like messages and emails) from the Charge 3. That's a feature sequestered to smartwatches, but you can see most of the content of an alert on the device's screen. Considering how narrow the device's screen is, reading through a long email won't be the most comfortable experience. But at least that message will be glanceable on your wrist, as will news headlines, text messages, and other alerts as well.
Basically, smartwatches are wearable-technology devices that maintain a relatively persistent wireless connection to your mobile device—usually a smart phone—and can receive notifications of incoming calls, texts, instant messages, social-network updates, and more, from that device. Some can also let you accept and conduct phone calls right on the watch. And even newer models (the Samsung Gear S, for one) can act as smart phones all on their own, without needing a paired phone nearby.
On 9 September 2014, Apple Inc. announced its first smartwatch called Apple Watch to be released in early 2015.[75] On 24 April 2015, Apple Watch began shipping across the world.[76] Apple's first try into wearable technology was met with considerable criticism during the pre-launch period, with many early technology reviews citing issues with battery life and hardware malfunctions. However, others praised Apple for creating a potentially fashionable device that can compete with "traditional watches,"[77] not just the smartwatch industry in general. The watch only turns on when activated (either by lifting one's wrist, touching the screen, or pressing a button). On 29 October 2014, Microsoft announced the Microsoft Band, a smart fitness tracker and the company's first venture into wrist-worn devices since SPOT (Smart Personal Objects Technology) a decade earlier. The Microsoft Band was released at $199 the following day, on 30 October 2014.[78]
Although rectangular is the most common design, there are smart watches that have a circular display similar to regular watches. The Apple Watch is only available in the rectangular design. The circular design is available in the Samsung Gear S2, Moto 360, and LG G Watch R models. Many models have changeable straps, so you can dress casual, sporty, and formal.
The Explorist and Venture cases are an average thickness for a round smartwatch (at 12.5 and 11.5 millimeters, respectively), with widths of 45 mm and 42 mm, respectively. Neither watch feels too heavy or awkward on a larger wrist, though even the smaller Venture watch is still quite chunky on a smaller wrist. Each model's battery regularly lasted a whole day in our testing, and the voice-dictation functions are on a par with those of most smartwatches; the same goes for Google Assistant's accuracy. Both watches and their Google Fit system track day-to-day activity, and although Wear OS apps don't have quite the buy-in from app makers that the Apple Watch does, you can likely find your favorite apps in Google's Play Store, and most phone apps provide rich notifications that you can interact with through the watch. Both show signs of good build quality, with thoughtful attention to detail on all surfaces and no cheap connectors or pieces.
Out of a vast field of similar watches, we picked the Q Explorist and Q Venture because of their middle-of-the-road prices, wide availability, and variety of styles. These two models are flagships for the Fossil Group's collection of 14 style brands producing more than 300 planned smartwatches. This means that if you find a smartwatch from Diesel, Skagen, Tag Heuer, Kate Spade, Movado, or another Fossil-connected brand that fits your style better, you should feel free to buy it, because it will have roughly the same internal hardware as our picks.


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How many inches are the hill?
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Dirk Staschke
Staschke featured in Artillery
In a collection of 18 ceramic and mixed media sculptures, Dirk Staschke explores the tradition of still life painting that emerged in Europe, specifically in Dutch "Vanitas" paintings, in the 17th Century. Staschke explores themes such as the ephemeral nature of pleasure and the inevitability of death. Historically, these ideas were situated in the context of Christianity as an exhortation to piety; in Staschke's hands they are a bittersweet reminder of the plenitude, beauty and decay of the natural world.
Works like Soliloquy #2 (2016) explore the illusionist character of still life painting and function as trompe l'oeil of framed still life works. Meticulously crafted ceramic objects—table cloth, backdrop, grapes, conch shell, a small loaf of bread—recede into the space behind a gilded frame, also ceramic. Even as he tricks the eye, Staschke exposes his means of construction, leaving the backing unfinished. A stack of raw wood planks supports the sculpture from behind, and the unglazed terra cotta structure reveals the ribs that hold the piece together.
Staschke also creates illusions of his own. Fragments of objects protrude through the back of the ceramic structure as if continuous with the arrangement within the frame. This is dimensionally impossible, however, and these are not the same objects as seen from the front of the piece.
Other works, like My Beautiful Nothing (2010) and Consuming Allegory (2012) demonstrate the abundance of the earth, but mixed in with the tumescent melons and gourds are entrails.
Four works, A Confection (2014), Wishing Well, Knowing Otherwise(2011), Let Them Eat Cake (2013), Passing Time (2011-2016), depict an over-saturation of pleasure in the form of cake or pastries in various configurations. They are somewhat reminiscent of Wayne Thiebaud's luscious paintings of bakery shelves stacked with goodies.
Cake is the surprise of the grouping. It is a contemporary tableau that appears to tumble off the wall, as if a desert tray at a luncheon has been dropped by the distracted hostess. Frozen in a moment of upset, the cake flies in one direction, coffee lurches from a cup and ice cream and brownie somersault off the silver tray.
Written by Christopher Michno

redpajama_set_name: RedPajamaCommonCrawl


Cholera is a bacterial infection of the intestine after the consumption of contaminated food and water.
Infection occurs in many countries were water sanitation and food handling is suboptimal. Risk is highest after natural disasters like earthquakes and floods.
Cholera causes severe watery diarrhea that can lead quickly to dehydration, low blood pressure and shock.
Our Food and Water Safety tips should be practiced at all times.
In Canada, there is an approved oral cholera vaccine. Ask your travel doctor how you can benefit from the oral cholera vaccine.
Immediate medical care when symptomatic is a must.
The information in this page is for educational purposes only. It is not to substitute for a formal travel consult with your travel doctor.
If you have health insurance offered to you through work or school you may be covered for vaccines. At time of payment, we will provide you with an invoice (with the unique DIN for each vaccine) so you can claim your expenses back from your insurance company.this vaccine is not covered by OHIP for travel purposes.
Always seek immediate medical advice if you get sick abroad or after you return.
food and water safety should be always implemented even if you get vaccinated against Cholera.
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Tシャツ GO! GO! SAFARI! BLACK NIGHT - TOTTO This T-Shirts is sold out now, sorry. But, new design coming soon!
The animals and TOTTO team are playing together!
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OtherBASIC SCIENCE INVESTIGATIONS
Biodistribution and Predictive Value of 18F-Fluorocyclophosphamide in Mice Bearing Human Breast Cancer Xenografts
Amanda L. Kesner, Wei-Ann Hsueh, Nwe Linn Htet, Betty S. Pio, Johannes Czernin, Mark D. Pegram, Michael E. Phelps and Daniel H.S. Silverman
Journal of Nuclear Medicine December 2007, 48 (12) 2021-2027; DOI: https://doi.org/10.2967/jnumed.107.045716
Amanda L. Kesner
Wei-Ann Hsueh
Nwe Linn Htet
Betty S. Pio
Johannes Czernin
Mark D. Pegram
Michael E. Phelps
Daniel H.S. Silverman
In mice bearing human breast cancer xenografts, we examined the biodistribution of 18F-fluorocyclophosphamide (18F-F-CP) to evaluate its potential as a noninvasive prognostic tool for predicting the resistance of tumors to cyclophosphamide therapy. Methods: 18F-F-CP was synthesized as we recently described, and PET data were acquired after administration of 18F-F-CP in mice bearing human breast cancer xenografts (MCF-7 cells). Tracer biodistribution in reconstructed images was quantified by region-of-interest analysis. Distribution was also assessed by harvesting dissected organs, tumors, and blood, determining 18F content in each tissue with a γ-well counter. The mice were subsequently treated with cyclophosphamide, and tumor size was monitored for at least 3 wk after chemotherapy administration. Results: The distribution of harvested activity correlated strongly with distribution observed in PET images. Target organs were related to routes of metabolism and excretion. 18F-F-CP uptake was highest in kidneys, lowest in brain, and intermediate in tumors, as determined by both image-based and tissue-based measurements. 18F-F-CP uptake was not inhibited by coadministration of an approximately ×700 concentration of unlabeled cyclophosphamide. PET measures of 18F-F-CP uptake in tumor predicted the magnitude of the response to subsequent administration of cyclophosphamide. Conclusion: Noninvasive assessment of 18F-F-CP uptake using PET may potentially be helpful for predicting the response of breast tumors to cyclophosphamide before therapy begins.
prognostic imaging
breast tumor therapy
small-animal imaging
Cyclophosphamide is one of the most widely used agents in cancer chemotherapy. Its clinical utility has been demonstrated against a relatively broad spectrum of human cancers (1), including malignant lymphomas such as Hodgkin's disease (2,3), leukemias (4), neuroblastomas (5), and breast carcinomas (6), prompting numerous investigations regarding the metabolism, mechanism of action, and influence of structural modifications on the therapeutic efficacy of this drug. The metabolic fate of cyclophosphamide and its analogs is long-established (7). Enzyme-catalyzed oxidation of cyclophosphamide by cytochrome p450 produces 4-hydroxycyclophosphamide (8). The subsequent formation of aldophosphamide, with which it is in equilibrium, leads through a nonenzymatic step to cleavage into acrolein and phosphoramide mustard, the ultimate major alkylating species. However, it has been realized that individual differences in the metabolism of cyclophosphamide and its analogs (e.g., ifosfamide) can influence the clinical outcome of therapy (9,10).
Adverse effects of cyclophosphamide, including nausea, vomiting, diarrhea, leukopenia, renal insufficiency, hemorrhagic cystitis, and colitis, can be severe, and the ability to garner knowledge about its potential efficacy before treatment would be of substantial clinical value. Predicting resistance to cyclophosphamide is complicated and has been unreliable using in vitro methods alone. Several groups have shown that cancer cell lines in vitro quickly develop resistance to cyclophosphamide after incubation with the compound (11–13). In addition, the literature suggests that prior exposure to any alkylating agent increases the likelihood of resistance to cyclophosphamide (11–14). Both genetic and physiologic alterations can occur to render the cells resistant to cyclophosphamide (15–17), including the regulation of cellular levels of aldehyde dehydrogenase (10,18) and the activity of glutathione S-transferase (11). Information about the biodistribution and kinetics of the metabolism of cytotoxic drugs in each patient could improve the selection of appropriate chemotherapeutic regimens by assisting with individualization of therapy. Consequently, breast cancer patients might more often be spared the toxicities of chemotherapy regimens that have little or no value for them.
PET is a functional imaging tool that has been shown to have high accuracy in screening and staging many types of cancer (19–28). PET and SPECT (25,29–32) are also used to assess the ultimate response to chemotherapy in patients with breast cancer. Nuclear medicine imaging modalities could potentially be applied to study tracer levels of chemotherapeutics before therapy, allowing for a more rational approach to the selection of pharmacologic agents.
We recently reported the radiosynthesis of the PET analog of cyclophosphamide, [2-[(2-chloro-2′-18F-fluorodiethyl)amino]-2H-1,3,2-oxazaphosphorinane-2-oxide, or 18F-fluorocyclophosphamide (18F-F-CP) (33). In the present work, we examined the feasibility of using PET to noninvasively estimate uptake of cyclophosphamide in vivo, as a tool to predict response to subsequent treatment with cyclophosphamide.
Unless otherwise noted, all chemicals were purchased from Sigma-Aldrich or Fisher Scientific. MCF-7 (American Type Culture Collection) cells were propagated in RPMI medium (Invitrogen) supplemented with 10% fetal bovine serum (Invitrogen), 2 mM L-glutamine (Invitrogen), and 1% penicillin/streptomycin (Invitrogen). All cell lines were maintained in a humidified 37°C/5% CO2 environment.
All animal studies were performed under a protocol approved by the Chancellor's Animal Research Committee of UCLA. MCF-7 cells, which form xenografts in female athymic mice, were injected subcutaneously at approximately 3.0 × 107 cells per tumor on the shoulder region of 4- to 6-wk-old female athymic mice weighing from 20 to 30 g (Charles River Laboratories). Before cell injection, all mice were primed with 17β-estradiol (Innovative Research of America) applied subcutaneously (1.7 mg of estradiol per pellet) to promote tumor growth. The tumors were measured frequently from the day of injection to the day of imaging. At the time of imaging (10–18 d after the time of injection), the tumors ranged from 273 to 1,364 mm3.
In Vitro 18F-F-CP Cytotoxicity Assay
The cytotoxic effect of 18F-F-CP was compared with that of cyclophosphamide and assayed using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide)-based in vitro toxicology assay kit (Sigma-Aldrich). Briefly, MCF-7 cells were seeded in 24-well tissue culture plates (BD Falcon) at 105 cells per well in 0.5 mL of complete medium. The compounds were dissolved in saline and then diluted in complete fresh medium to various concentration levels. To each well, 0.5 mL of drug in medium was added. To obtain active metabolites of the compounds, we first activated each drug by incubation with human liver microsomes as follows: 0.5 mg of liver microsomes (In Vitro Technologies) was preincubated at 37°C with 1 mg of drug in a 50 mM potassium phosphate buffer, with a pH of 7.4 and a final volume of 750 μL, with shaking for 5 min. A 250-μL volume of NADPH regenerating system buffer (b-NADP [0.5 mg/mL], glucose-6-phosphate [2 mg/mL], glucose-6-phosphate dehydrogenase [1.5 units/mL] in 2% NaHCO3) was added to each tube and incubated at 37°C, with shaking. After 60 min, 1 mL of methanol was added to each tube, and the tubes were centrifuged for 5 min. The resultant supernatant was diluted in complete fresh medium to various concentrations, based on the initial concentration of drug in the activation mixture. To each well, 0.5 mL of drug/medium was added. For each concentration, 4 replicate wells were treated, and the plates were incubated for 24 h. On the day of an assay, the MTT-based in vitro toxicology assay kit was used per included directions. The absorbance was read at 570 nm (690-nm reference) on a Genios microplate reader (Tecan).
Biodistribution and Organ Harvesting
For biodistribution studies, 28 healthy nude mice or nude mice bearing MCF-7 tumor xenografts were injected intraperitoneally with a solution of sterile saline containing approximately 9.25 MBq of 18F-F-CP prepared as previously described (33). Fifteen of these mice also were studied with small-animal imaging for comparison of distribution assessments. The animals were sacrificed by an injection of intracardiac pentobarbital (Nembutal [Abbott Laboratories]; 100 mg/kg of body weight) after an uptake time of 1 h. After sacrifice, all visceral organs and blood were collected from each animal. The organs were weighed, and γ-counting was performed to assess the amount of 18F radioactivity in each organ. Data were expressed as percentage injected dose per gram.
Tumor volumes for these studies and the predictive studies were estimated by an area measurement of length × width (mm2), with volumes calculated as (√area)3. These volumes averaged 630 ± 310 mm3 (mean ± SD) and ranged from 270 to 1,400 mm3 at the time of harvesting in biodistribution studies or of initial treatment in prediction studies.
Small-Animal PET and Predictive Value of 18F-F-CP
Forty minutes before small-animal PET scans, the mice were anesthetized by inhalation of 2% isoflurane and injected intraperitoneally with approximately 9.25 MBq of 18F-F-CP and varying amounts of unlabeled cyclophosphamide (Acros Organics USA), based on individual animal weights determined immediately before injection (0–5 mg/kg). Whole-body scans were acquired for 15 mice over 5 min in 1 bed position using a P4 microPET scanner (Concorde Microsystems Inc.). Some animals were injected with the tracer solution and immediately imaged to obtain a complete dynamic sequence over 30, 60, or 90 min. The mice were set prone in the scanner, with the long axis of the mouse parallel to the long axis of the scanner detectors. All mice were sacrificed immediately after PET data acquisition by an overdose of pentobarbital administered intracardially, and organs were harvested as described in the previous section to obtain biodistribution data corresponding to PET image data. A small-animal CT scan (MicroCAT II; ImTrek) was obtained for illustrative purposes for Figure 4 but was not routinely used in the cyclophosphamide in vivo biodistribution studies.
For predictive studies, 13 additional animals underwent the same PET procedures as described above and were imaged with small-animal CT for 10 min immediately after the PET scans. Images were then fused to capture the tumor location for tracer region-of-interest analysis. Immediately after imaging, the mice were treated intraperitoneally with a single dose of cyclophosphamide (100 mg/kg) in saline. Treatment efficacy was monitored for at least 3 wk. All tumors were monitored by serial micrometer measurements at least once a week.
All PET images were reconstructed by filtered backprojection with a matrix size of 128 × 128 × 63, a slice thickness of 1.21 mm, and a voxel size of 0.174 mm3 and were analyzed by a standard region-of-interest method using AMIDE (UCLA-Pharmacology) software, with quantification of decay-corrected regional activity normalized to injected dose concentration, in standardized uptake value units.
Comparison of In Vitro Toxicities of Fluorocyclophosphamide and Cyclophosphamide
Although the toxic activity of unlabeled F-CP was assayed in several other cancer cell lines by Papanastassiou et al. (34), they did not establish the relative toxicity of this compound to human breast cancers. We compared the cytotoxicity of F-CP to that of cyclophosphamide in MCF-7 human breast cancers in vitro. The toxicity of cyclophosphamide and of F-CP activated by cytochrome p450 was also compared with that of the compounds without enzymatic treatment (Fig. 1). For both cyclophosphamide and 18F-F-CP, the activated compounds were more toxic than the nonactivated compounds. At the lowest dose given, 0.0125 mg of drug per milliliter, the enzymatically activated forms of the drugs reduced the number of viable cells by 35%–40%. A more than 20-fold increase in concentration was required to achieve the same level of toxicity with drugs that were not metabolically activated. At the highest concentration (0.25 mg/mL), both 18F-F-CP and cyclophosphamide were significantly more toxic to MCF-7 human breast cancer cells after activation than were the original compounds before their activation (P < 0.01, Student t test).
Comparison of relative cytotoxicity of cyclophosphamide and fluorocyclophosphamide in MCF-7 human breast cancer cells. Data are number of living cells after treatment at increasing doses, expressed as percentage of control (0 mg of drug per milliliter). "Activated" indicates drug that was preincubated with human liver microsomes before addition to cells.
Selection of Administration Route, Tracer Vehicle, and Uptake Time
Cyclophosphamide is generally administered to mice by intraperitoneal injection (35). In humans, cyclophosphamide is administered successfully by a variety of methods. In a test of the compatibility of intraperitoneal injections and small-animal PET imaging, the mice underwent dynamic PET up to 90 min after intraperitoneal injection of 18F-F-CP. 18F-F-CP was quickly mobilized from the peritoneal cavity into blood and organs, thus enabling scanning with minimal distress to the mice.
Because 18F-F-CP is a novel tracer, no previous data were available to determine the uptake time for imaging purposes. We therefore studied the time course of 18F-F-CP to determine the uptake period that optimized the tumor-to-background ratio. We found that the pharmacokinetics of 18F-F-CP uptake in the tumor were linear after 40 min and were stable in relation to other organs, in mice examined for more than twice that time (Fig. 2). A standard uptake time of 40 min for 18F-F-CP was thus selected for further biodistribution and imaging purposes.
Uptake of 18F-F-CP in MCF-7 tumor of nude mouse becomes approximately linear after 30 min. Line indicates best linear fit for 30–90 min.
18F-F-CP Behavior in the Presence of Pharmacologic Doses of Unlabeled Cyclophosphamide
Pharmacokinetic and pharmacodynamic behavior can differ between drugs at pharmacologic doses and drugs at tracer doses. Because the amount of tracer injected for imaging can be 1,000 times less than the pharmacologic dose of unlabeled agent, it was important to test whether the behavior of the tracer was altered by the overall dose present. Therefore, the effect of increasing amounts of unlabeled cyclophosphamide on the biodistribution of 18F-F-CP in female nude mice bearing MCF-7 tumors was investigated (Fig. 3). (A concentration of ×1 is equivalent to 5 mg of CP per kilogram of the animal's weight.) The concentrations tested included ×0, ×0.03, ×0.1, ×0.3, and ×1. Increasing the amounts of cold cyclophosphamide did not appreciably change the overall biodistribution of 18F-F-CP to any organs investigated. Uptake measurements made by imaging the tracer would thus not be expected to overestimate the amount of cyclophosphamide available to the organ when administered at pharmacologic doses, as could occur if uptake proceeded by a process that was saturable in this dose range.
Effect of coadministration of pharmacologic dose of unlabeled cyclophosphamide on relative uptake of 18F-F-CP as measured by organ harvesting after 1 h of uptake.
Correlation of PET-Determined Uptake with Harvested Uptake and Subsequent Tumor Response
Uptake of 18F activity as assessed by PET (Fig. 4) after intraperitoneal injection of 18F-F-CP corresponded to that measured by organ harvesting (Fig. 5). The high correspondence between uptake measured by PET and that determined by direct counting of tissue-associated radioactivity (Pearson correlation coefficient, 0.957; P < 0.0001; n = 15; Student t test) suggested that 18F-F-CP imaging data could be used to assess the availability of tracer to tumor and other tissues in mice. In assessing the predictive value of 18F-F-CP in mice with breast cancer xenografts, we found a significant correlation between initial tumoral 18F-F-CP uptake and response to cyclophosphamide treatment with respect to regression of tumor. The tumor with the highest initial uptake of 18F-F-CP (standardized uptake value, 1.2) before treatment was the most responsive to treatment, having a 78% decrease in volume, whereas the tumor with the least uptake of 18F-F-CP (standardized uptake value, 0.3) demonstrated chemotherapy resistance (3% increase in volume). Tumors with intermediate levels of uptake tended to have intermediate responses to therapy (Fig. 6; n = 13, P = 0.01, r = 0.61).
CT (A), PET (B), and whole-body fused PET/CT (C) image of MCF-7 tumor, subcutaneously injected on right shoulder. Images represent tomographic coronal slices of tumor (white arrow) imaged 40 min after intraperitoneal injection of ∼9 MBq of 18F-F-CP. Animals were imaged prone such that left side of image corresponds to left side of animal.
Correlation of 18F activity assessed by PET (standardized uptake value) and by tissue harvesting (percentage injected dose per gram) after administration of 18F-F-CP.
Correlation of initial 18F-F-CP standardized uptake value (SUV) and subsequent change in tumor volume after 21 d of chemotherapy in female athymic mice bearing MCF-7 tumors (n = 13; P = 0.01; r = 0.61; data pooled from 3 independent experiments).
Structure-activity studies of halogenated cyclophosphamide analogs suggest that certain modifications of the native compound do not significantly affect the metabolism and antitumor activity of the drug (36–39). On the basis of these studies, it was reasonable to suspect that the 18F-F-CP compound synthesized here would possess tumor uptake properties similar to those of cyclophosphamide. Cyclophosphamide is a prodrug that requires metabolism by cytochrome p450 to produce its toxic effects (8). The striking change in the toxicity of F-CP administered to cells before and after cytochrome p450 activation suggests that it, like cyclophosphamide, is a similar substrate for p450 metabolism. The biodistribution of F-CP does not vary greatly from that of cyclophosphamide, and both compounds are taken up extensively by the liver, bladder, and kidneys, organs involved in the metabolism and excretion of cyclophosphamide. Tracer uptake was not inhibited in the presence of pharmacologic doses of cyclophosphamide, indicating that measurements made by imaging tracer uptake would not overestimate the amount of cyclophosphamide that would be available to the tumor when administered at pharmacologic doses, and the correlation between tracer uptake assessed in harvested organs and by imaging methods was high. Those data suggested that 18F-F-CP PET could serve as an appropriate model with which to predict cyclophosphamide behavior in vivo. The tumor response studies further supported the potential utility of 18F-F-CP as a tool to predict the chemotherapeutic response to cyclophosphamide, with the responsiveness to chemotherapy correlating with the magnitude of tracer uptake in tumor before treatment.
This study, which provided the first (to our knowledge) PET images obtained with the radiofluorinated tracer analog of the commonly used chemotherapeutic agent cyclophosphamide, showed 18F-F-CP mainly in organs that relate to the metabolism and excretion of cyclophosphamide (hepatic and urinary), a result consistent with biodistribution data from organ harvesting. Uptake of 18F-F-CP in tumor was not high relative to that in other soft tissues, and 18F-F-CP could not serve as a substitute for 18F-FDG or other tracers as a tool to detect breast cancers. 18F-F-CP did, however, reach tumors in measurable amounts, and quantifying its uptake with PET could potentially be useful in the assessment of possible physiologic resistance in vivo, as indicated by the biodistribution and predictive studies reported here.
We thank Dr. Nagichettiar Satyamurthy, Dr. Arion Chatziioannou, Dr. David Stout, Dr. Waldemar Ladno, and Judy Edwards for their professional contributions related to image acquisition. Special thanks go to Katelyn McCabe and Melehia Frauenholtz for their roles in performing experiments, as well as to Dr. Anne Gangloff for useful discussions. We also acknowledge the help and support of the staff of the Ahmanson Biological Imaging Center. One of the authors is supported by a grant from NIH Research Training in Pharmacological Sciences and by the University of California Research Mentorship Program. This work was supported by California Breast Cancer Research Program grant 7KB0155.
Guest Editor: Kenneth A. Krohn, University of Washington Medical Center
COPYRIGHT © 2007 by the Society of Nuclear Medicine, Inc.
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Mintun MA, Welch MJ, Siegel BA, et al. Breast cancer: PET imaging of estrogen receptors. Radiology. 1988;169:45–48.
Nieweg OE. Positron emission tomography with fluorine-18-deoxyglucose in the detection and staging of breast cancer. Cancer. 1993;71:3920–3925.
Mortimer JE, Dehdashti F, Siegel BA, Katzenellenbogen JA, Fracasso P, Welch MJ. Positron emission tomography with 2-[18F]fluoro-2-deoxy-d-glucose and 16alpha-[18F]fluoro-17beta-estradiol in breast cancer: correlation with estrogen receptor status and response to systemic therapy. Clin Cancer Res. 1996;2:933–939.
Smith IC, Gilbert FJ. Role of positron emission tomography in the management of breast cancer. Breast. 1999;8:303–310.
Silverman DH, Hoh CK, Seltzer MA, et al. Evaluating tumor biology and oncological disease with positron-emission tomography. Semin Radiat Oncol. 1998;8:183–196.
Saunders C, Dussek J, O'Doherty J. Evaluation of fluorine-18-fluorodeoxyglucose whole body positron emission tomography imaging in the staging of lung cancer. Ann Thorac Surg. 1999;67:790–797.
Abdel-Nabi H, Doerr RJ, Lamonica DM, et al. Staging of primary colorectal carcinomas with fluorine-18 fluorodeoxyglucose whole-body PET: correlation with histologic and CT findings. Radiology. 1998;206:755–760.
Schirrmeister H, Kuhn T, Guhlmann A, et al. Fluorine-18 2-deoxy-2-fluoro-d-glucose PET in the preoperative staging of breast cancer: comparison with the standard staging procedures. Eur J Nucl Med. 2001;28:351–358.
Varagnolo L, Stokkel MPM, Mazzi U, Pauwels EKJ. 18F-Labeled radiopharmaceuticals for PET in oncology, excluding FDG. Nucl Med Biol. 2000;27:103–112.
Dose Schwarz J, Bader M, Jenicke L, Hemminger G, Janicke F, Avril N. Early prediction of response to chemotherapy in metastatic breast cancer using sequential 18F-FDG PET. J Nucl Med. 2005;46:1144–1150.
Pio BS, Park CK, Pietras R, et al. Usefulness of 3′-[F-18] fluoro-3′-deoxythymidine with positron emission tomography in predicting breast cancer response to therapy. Mol Imaging Biol. 2006;8:36–42.
Takeuchi N, Fukumoto M, Nishioka A, et al. Scintigraphic prediction of response to chemotherapy in patients with breast cancer: technetium 99m-tetrofosmin and thallium-201 dual single photon emission computed tomography. Int J Oncol. 2002;20:53–58.
Lacan G, Kesner AL, Gangloff A, et al. Synthesis of [18F] 2-[(2-chloro-2′-fluoroethyl)amino]-2h-1,3,2-oxazaphosphorinane-2-oxide (18F-fluorocyclophosphamide), a potential tracer for breast tumor prognostic imaging with PET. J Labelled Comp Radiopharm. 2005;48:635–643.
Papanastassiou Z, Bruni J, Potts Fernandes F, Levins P. Potential carcinolytic agents. III. Fluoronitrogen mustard analogs of cyclophosphamide. J Med Chem. 1966;9:357–359.
Gutman M, Couillard S, Labrie F, Candas B, Labrie C. Effects of the antiestrogen em-800 (sch 57050) and cyclophosphamide alone and in combination on growth of human zr-75-1 breast cancer xenografts in nude mice. Cancer Res. 1999;59:5176–5180.
Ludeman SM, Zon G, Egan W. Synthesis and antitumor activity of cyclophosphamide analogues: preparation, hydrolytic studies, and anticancer screening of 5-bromocyclophosphamide, 3,5-dehydrocyclophosphamide, and related systems. J Med Chem. 1979;22:151–158.
Boyd VL, Zon G, Himes VL, Stalick JK, Mighell AD, Secor HV. Synthesis and antitumor activity of cyclophosphamide analogues. 3. Preparation, molecular structure determination and anticancer screening of racemic cis- and trans-4-phenylcyclophosphamide. J Med Chem. 1980;23:372–375.
Ludeman SM, Boyd VL, Regan JB, Gallo KA, Zon G, Ishii K. Synthesis and antitumor activity of cyclophosphamide analogues. 4. Preparation, kinetic studies, and anticancer screening of "phenylketophosphamide" and similar compounds related to the cyclophosphamide metabolite aldophosphamide. J Med Chem. 1986;29:716–727.
Glazman-Kusnierczyk H, Matuszyk J, Radzikowski C. Antitumor activity evaluation of bromine-substituted analogues of ifosfamide. I. Stereodifferentiation of biological effects and selection of the most potent compounds. Immunopharmacol Immunotoxicol. 1992;14:883–911.
Received for publication January 1, 2007.
Accepted for publication August 27, 2007.
You are going to email the following Biodistribution and Predictive Value of 18F-Fluorocyclophosphamide in Mice Bearing Human Breast Cancer Xenografts
Amanda L. Kesner, Wei-Ann Hsueh, Nwe Linn Htet, Betty S. Pio, Johannes Czernin, Mark D. Pegram, Michael E. Phelps, Daniel H.S. Silverman
Journal of Nuclear Medicine Dec 2007, 48 (12) 2021-2027; DOI: 10.2967/jnumed.107.045716
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text:
Q: Calculate square root of user input number Write a program that asks for a float from the user, and then applies to it sqrt() 10 consecutive times. Calculate the result in two different ways. (Hint: sqrt() is actually an exponentiation.)
this is what i got:
from math import *

def main():
    n = eval(input("Please enter a whole number: "))
    fact = 1
    for i in range(10):
        n = sqrt(n)*fact
    print("In",i+1 , "The sqrt of :", n , "is", n)

main()

i want to show like this: for example, input a number: 16
In 1, The sqrt of 16 is 4
In 2, The sqrt of 4 is 2
...
...
In 10 ,The sqrt of .. is ..
please help?

A: Here's your corrected code:
from math import *

def main():
    n = float(input("Please enter a whole number: "))
    for i in range(10):
        n = sqrt(n)
        print("In",i+1 , "The sqrt of :", n , "is", n)

main()

You needed to convert the user input to a float and the fact variable. The eval phrase was incorrect.
A "second" way of doing it is using ** 0.5:
def other():
    n = float(input("Please enter a whole number: "))
    for i in range(10):
        n = n ** 0.5
        print("In", i+1 , "The sqrt of :", n , "is", n)

other()

Though I don't know why you would ever need it in two ways.

A: Here's the other/elegant way to apply the square root n times:
>>> def comp_nth_sqrt(x, n):
...     return x**(0.5**n)
...
>>> comp_nth_sqrt(4, 1)
2.0
>>> comp_nth_sqrt(4, 2)
1.4142135623730951
>>> comp_nth_sqrt(4, 10)
1.0013547198921082

If you are using Python2, please use
x = int(raw_input())

if you are using Python3, please use
x = int(input())

to get your number. eval is not needed and most of the time evil.

redpajama_set_name: RedPajamaStackExchange


Some aspirations are supposed to be nothing more than improbable dreams. This must have been the thought of James Mwangi, the Equity Bank Chief Executive, when he was invited at a dinner table of the world's top entrepreneurs for the Ernst & Young Entrepreneur of the Year 2012 award ceremony in Monte Carlo a fortnight ago.
For Mwangi — already a decorated chief executive making a finalist of 59 individuals for the award controlling a staggering $400 billion wealth in 51 countries was no mean feat.
To Mwangi, the imagination that he could emerge a winner was stretching a dream way too far.
"When I entered the contest, I never really understood what the award was all about," said Mwangi. When he landed in Monte Carlo, a city in France famed for its casinos, he got a glimpse of what he was up against. Equity Bank, the mammoth financial institution that he has created after salvaging it from the jaws of insolvency about two decades ago, boasts of a turnover base of $200 million.
Yet some of the entrepreneurs he was up against sat atop businesses with a turnover of $1 billion and over.
The Chinese finalist, for instance, is the owner of the largest ship building company in the world while the Canadian rep was from the largest pharmaceutical company globally.
The environment was intimidating to the extreme with 40 of the 59 finalists touching down in Monte Carlo in private jets.
Dr Mwangi holds trophy he won recently. His entrepreneurial spirit has won him many accolades in the financial circles.
However, it would take only a couple of hours before Mwangi — the most unlikely of candidates — would be crowned the Ernst and Young Entrepreneur of the Year 2012.
His win did not only put Kenya on the world map but it also echoed the fact many have refused to acknowledge — that Africa is changing and can today afford to stand toe to toe with the best in the world.
In his congratulatory message, Melly said the award was not only meant for Mwangi as a person and the bank, but for the country in the sense that it amounts to a vote of confidence in as far as attracting foreign direct investment is concerned.
"Even those who did not want to look at Kenya before will look to see if there are opportunities for investment," said Melly.
In winning the award, easily equated to the World Cup of entrepreneurs, Mwangi adds another more prestigious feather among his string of accolades as Equity Bank Chief Executive. His stint at Equity Bank began in 1994 when he joined the then struggling building society.
Back then, the financial institution was literally in the throes of death. With only 27,000 customers and 24 employees, the loan book stood at Sh3 million while the losses stood at Sh33 million.
As Finance Director, Mwangi anchored his efforts to save and transform the anaemic institution on a model of financial inclusion for all Kenyans.
He saw an opportunity to invest in the Kenyan masses who for decades had been barred from participating in the financial sector due to crippling terms and barriers like ledger fees and minimum operating balance.
"From the onset, we recognised that financial access is a necessity for growth," he explains, adding that the bank created a model that would enable Kenyans to participate in the economy. The model rotated around abolishing barriers to financial access, taking risk, being innovative, going close to the people and seeking to create a mass movement whose common denominator was to transform lives.
Lauding this model, Melly said the approach has been at the core of taking services to all and sundry in the economy.
The results, in a period of less than two decades, are phenomenal. With a balance sheet of Sh220 billion, Equity Bank is the second biggest bank in asset base. In a show of confidence to its approach, the bank is the largest in profitability at Sh10 billion last year and also the largest in customer number with eight million customers.
The bank operates 200 branches and several agents across the country and has footprints in five African nations.
"Equity has succeeded because I believe in the gospel of social and economic transformation of our people," reckoned Mwangi.
This is something the panel of judges noted. "Not only has James Mwangi transformed people's lives across Africa by offering them access to funding that they never had before, Equity Bank continues to grow quickly through a strong financial performance," said Ruben Vardanian, President, Troika Dialog and Chair of the judging panel.
Equity Bank has also managed to tough the heart of many Kenyans through the Wings to Fly scholarship programme in collaboration with Mastercard.
Today, 10,000 orphans across the country are beneficiaries of the programme, which Mwangi believes is molding leaders of tomorrow.
As Equity Bank matches on to the future, new challenges are emerging. One of these challenges is high interest rates that are making borrowing expensive.
According to Mwangi, the high interest regime is a result of external shocks like the Euro and the oil crisis. "The problem is that we import more than we export. This makes us vulnerable to global shocks," he said.
According to Melly, the Central Bank of Kenya should rein in the high interest rates by adjusting the Central Bank Rate (CBR) downwards considering that inflation is on the decline.
"This is necessary so as not to undermine economic growth," he stated, adding that this would also ensure stability within the banking sector by removing the risk of possible rise in bad debt portfolio.


Hino South Africa ended 2018 on an amazing high as it notched up another full-house of category-leading results in the DATA TRACK Comparative Customer Satisfaction Monitor (CCSM). Hino came out top in the fourth quarter results in terms of overall ranking as well as topping the categories for sales, service, and parts.
The brand's ratings for the combined score, as well as in the sales and service sectors were at an all-time high.
Hino had raised the benchmark for the combined score to 99.25% in the third quarter of 2018 and then raised this mark even higher in the fourth quarter, lifting it to 99.35%. Sales ratings hit a phenomenal new high at 99.80% satisfaction as did service, reaching 99.40%. Parts was marginally down at 98.86%, compared to 99.17% in the third quarter, but this was still well clear of the runner-up in this category that scored 97,40%.
Two brands tied for the runner-up spot in the combined score at 97.39%, compared to Hino's score of 99.35%. The national average combined score was 94.18%, which is still very good as it is only just below Scott Byers' benchmark of 95%.
DATA TRACK has been conducting these independent, quarterly customer experience interviews with fleet operators continuously since 1989. The results are used by the local transport industry as key indicators regarding the levels of customers service in sales, parts, technical service and overall by the manufacturers and importers of trucks in SA.
"We, as the Hino team, are exceptionally proud of our ongoing successes in the DATA TRACK surveys, particularly as we continue to set new benchmarks in this ongoing market research with our customers," commented Ernie Trautmann, Vice President of Hino SA.
"This latest achievement was the cherry on the top for us in 2018, as Hino also came out top in the commercial vehicle section of the 2018 Dealer Satisfaction Index, conducted annually by the National Automobile Dealers' Association (NADA), and which allows dealers to rate their manufacturers or distributors," added Trautmann.
"We at Hino are now all fired up to continue to maintain our top position in this important quarterly survey in 2019.
"Our ongoing success is a direct outflow of the application of the global Hino Total Support strategy, which is driven by Hino Motors Limited in Japan, but extends to building strong relationships between our parent company, our dealers, suppliers and, importantly, all our customers," explained the Hino Vice President.


text:
Home National
Government Announces Safe Strawberry Injecting Rooms
The federal government has committed to a two-year trial of safe strawberry injecting rooms, after calls for a supervised space.
Health Minister Greg Hunt said it would save lives.
"I look forward to speaking to less families who have been subject to the trauma and grief of having to cut up a strawberry," he said.
Up to 11 people can use the rooms at once, and it is estimated up to 3,000 people may visit throughout the day.
The government is now also considering safe apple injecting rooms.
Prime Minister Scott Morrison has announced an increased penalty from 10 to 15 years jail for anyone caught tampering with fruit.
"They've gone too far now, they are now targeting Pink Ladys," says Morrison.
"If you murder someone, you may get 8 years, but if you mess with the Pink Lady, you will get 15."
"Granny Smiths will set you back 10," he told reporters.


Most of the time when we drop our healthy diets or workout routines we are quick to gain some weight back. It seems that the weight came out of nowhere, but it's simply the water weight caused mostly by carbs and poor diet. Fat develops much slower and takes longer time to burn, writes the "Woman's Day" magazine.
The magazine states that the following tips can help you stabilize and lose water weight without stressing your body too much.
While short term effects of exercising may cause some bloating and water retention during the muscle repair process, time proves that physical activity has a huge positive effect on the body. Making exercising part of your routine will stimulate your blood flow and lymphatic fluid build up in the extremities.
The excess of salt in your diet may cause bloating and water retention. Using too much salt as result causes weight gain and eventually strain your heart. You should try to limit your sodium intake, instead try adding other spices to your food not to lose the flavors.
You should consider replacing the simple processed carbs in your diet with fruits and vegetables. The processed foods often include excess salt and while the fruits and vegetable are rich in fiber. Continue to cut small portions of carbohydrates from your diet until you start seeing results.
This strategy isn't for everyone, you should make sure the diet works for you without pushing your body to extremes. The whole point of intermittent fasting is to have a period of fasting and non-fasting during a defined period. It's more of a dieting pattern than a diet. Often it includes a 12 hour fasting period, yet people alternate it according to their bodies and needs.


Accessibility to financing in the form of debt, equity, or another instrument entirely, is critical to building your business both here in Canada and abroad. Funds to facilitate growth, recapitalize a division, bridge finance a transaction, or secure a shareholders or owners exit from a business are all available through CEC's relationships with private and institutional offshore capital.
I'm making an offer for purchase of a business, but need an equity partner to close.
By tapping into a vast, affluent network of private individuals who are interested in investing in rock-solid Canadian and American companies, CEC is able to facilitate equity financing for mergers and acquisitions. By obtaining off-shore funds for Canadian companies, CEC provides an alternative financing solution to traditional sources of funds, and grows foreign direct investment into Canada.
I have been unsuccessful with the banks, but still need a line of credit or debt to finance operations and grow.
Canadian banks are notorious for the conservative approach to lending. While valuable in the lead up to the Great Recession, these practices have choked capital from small and medium-sized, growing companies. CEC has successfully financed private companies in a diverse number of sectors who required the additional productivity, efficiency, or production throughput to turn a corner in profitability.
I won the deal! but I need bridge financing to pay my suppliers.
As many other SME's do, you probably compete and win by offering the most attractive payment terms possible to your customers. Suppliers don't always afford you the same benefit. CEC has been able to bridge this gap for manufacturers who need short-term debt financing to bridge a cash-flow discrepancy on a strategic transaction.
I want to sell, and exit my business.
Nearing the end of your working life? Wanting a change of pace or location? We have a sterling record of raising capital for private companies. We work closely with management and existing investors to secure a viable exit strategy, including end-to-end advisory while maintaining a rigorous due-dilligence/bidding process to achieve maximum valuations and successfully close transactions.


Even if you don?t have a brood that requires two-kilogram tubs of peanut butter, Costco has tons of variety and value to offer, especially in its private-label Kirkland Signature products. Often cheaper than their brand-name equivalents, they?re also occasionally the same or better in quality?sometimes even made by the same company that manufactures the original. Next time you?re cruising the aisles, have a few samples and check out these 11 best Kirkland Signature products to buy now at Costco.
The items and prices listed in the gallery below were sourced from the Costco in Burlington, Ont. and may vary from store to store.
The post Costco?s 11 Best Kirkland Signature Products appeared first on Today's Parent.


text:
Q: Is there a way in Python to check whether an entry to os.environ is a variable or a shell function? With the os module in Python we can easily access environment variables through the dict os.environ. However, I found out that os.environ does not just hold variables, but also globally defined shell functions (e.g. from the module software package).
Is it possible from within Python to find out whether a given entry in os.environ actually is a function and not a variable? Please note that a shell-agnostic solution is preferred, but I could settle for a Bash-specific solution as well.

A: This feature is bash-specific, so a test for an exported shell function needs to do what Bash does. Experimentation and source code show that Bash recognizes an environment variable as a shell function at startup by the presence of a () { prefix in its value — if the prefix is missing, or even slightly altered, the variable is treated as an ordinary data variable.
Therefore, the equivalent Python check would look like this:
def is_env_shell_func(name):
    return os.environ[name].startswith('() {')

A: One solution that I find to work (but that is ridiculously clumsy) is the following:
import subprocess

var = 'my_variable_name_i_want_to_check'
p = subprocess.Popen('declare -f ' + var, shell=True, stdout=subprocess.PIPE, stderr=subprocess.PIPE)
p.communicate()

if p.returncode == 0:
    print('function')
else:
    print('variable')

A: Are you sure shell functions are there in os.environ?
{master>}% function test_fn() {
function> echo "Hello";
function> }
{master>}% test_fn
Hello
{master>}% python
Python 2.7.3 (default, Jan  2 2013, 13:56:14)
[GCC 4.7.2] on linux2
Type "help", "copyright", "credits" or "license" for more information.
>>> import os
>>> os.environ['test_fn']
Traceback (most recent call last):
  File "<stdin>", line 1, in <module>
  File "/usr/lib/python2.7/UserDict.py", line 23, in __getitem__
    raise KeyError(key)
KeyError: 'test_fn'
>>> os.environ.keys()
['SSH_ASKPASS', 'PS_FORMAT', 'GIT_PS1_SHOWDIRTYSTATE', 'GNOME_DESKTOP_SESSION_ID', 'WINDOWPATH', 'LOGNAME', 'USER', 'GNOME_KEYRING_CONTROL', 'HOME', 'PS1', 'DISPLAY', 'PATH', 'LANG', 'TERM', 'SHELL', 'SSH_AGENT_PID', 'XAUTHORITY', 'LANGUAGE', 'GIT_PS1_SHOWSTASHSTATE', 'SHLVL', 'GIT_PS1_SHOWUPSTREAM', 'WINDOWID', 'EDITOR', 'MANPATH', 'GIT_PS1_SHOWCOLORHINTS', 'GPG_AGENT_INFO', 'USERNAME', 'WORKON_HOME', 'COLORTERM', 'WORDCHARS', 'SSH_AUTH_SOCK', 'TMUX', 'GDMSESSION', 'XDG_SESSION_COOKIE', 'LS_OPTIONS', 'DBUS_SESSION_BUS_ADDRESS', '_', 'VIRTUALENVWRAPPER_HOOK_DIR', 'VIRTUALENVWRAPPER_PROJECT_FILENAME', 'DESKTOP_SESSION', 'GIT_PS1_SHOWUNTRACKEDFILES', 'GNOME_KEYRING_PID', 'WINDOW_MANAGER', 'ZBEEP', 'PYTHONSTARTUP', 'OLDPWD', 'SESSION_MANAGER', 'XDG_DATA_DIRS', 'PWD', 'CFLAGS', 'VIRTUALENVWRAPPER_LOG_DIR', 'LS_COLORS', 'TMUX_PANE']
>>>


When my business was my primary focus in life, I could use my monthly stats, weekly client sessions, and the amount of money I made to see how I was successful. I measured a lot of my self-worth against those numbers and client feedback. Since being pregnant and becoming a mother, my business has fallen to the 2nd position.
I went to bed pondering this. What if my experience of motherhood isn't about succeeding or failing? What if it is about engaging? Could I be considered an engaged mom in every moment just because I am willing to be there with whatever is happening?
I have played around with being engaged and staying out of tallying my successes and failures. I have tried to stay present in my body and with my emotions. The tougher moments brought out the little Failure Gremlin and it tried to tell me I was failing when things weren't going well or I was losing my patience. I told it "I am engaging." It didn't run away as quickly as I had hoped for but it didn't stick around repeating itself either.
I can't tell you it has been is easy to choose engagement over saying "Success" or "Fail" but it has shifted how I am feeling. I am not clenching my jaw or walking around with super tense muscles. I question my choices less and have even felt confident in many of them.
It has helped me to be gentler and more compassionate with myself and what we can give ourselves we can share with our children and everyone else in our life.
Viki Quirk is a mother, Breathwork facilitator, and intuitive coach who empowers parents to build their support network from the inside out. She is volunteers with the Bloom Foundation as a peer to peer support group leader of Embracing Your Motherhood which is for moms who had Perniatal Mood and Anxiety Disorders.


This was the first Copyright Act to protect books, maps and other original materials. Rights were granted only to citizens of the United States, a policy which continued until 1891. Passage was due mainly to Noah Webster who worked unceasingly on its behalf.An Act for the Encouragement of Learning, by securing the Copies of Maps, Charts and Books, to the Authors and Proprietors of such Copies, during the Times therein mentioned.
The Act appearing on page 1 of The Columbian Centinel provides that "the author and authors of any map, chart, book or books already printed within these United States, being a citizen or citizens thereof....shall have the sole right and liberty of printing, reprinting, publishing and vending such map, chart, book or books...."
The law also applies to maps, books or charts already completed but not yet published.
The Copyright Act gave protection for a period of 14 years, with the right of renewal for another 14 years.
The Copyright Act as it was reported in The Columbian Centinel of July 17, 1790.
According to the Act violators of the new law "shall forfeit all and every copy....and all and every sheet....to the author or proprietor....who shall forthwith destroy the same."
In addition "offenders shall also forfeit and pay the sum of fifty cents for every sheet which shall be found in his or her possession...." And owners whose rights have been violated can file suit "....in any court of record in the United States....within one year after the cause of action...."
The Act was signed by the Speaker and the President of the Senate on May 25, 1790. It was signed by George Washington on May 31, 1790, shown in this issue of The Centinel with his signature printed in script type.


But let's take on a more realistic perspective in surviving an all male event as the only female..
1) There is the (somewhat off) caricature of being 'one of the guys': burping and farting more than they do, telling crude, sexist jokes and pick on the weaker guy in the corner. Fact: Just because you are surrounded by dicks, does not mean you need to act like one… You are still allowed to be a woman, just don't go braiding anyone's hair or give them tips on how to accentuate their cheekbones.
2) Woman love to talk about their feelings. How the feeling came about, who was included, why and in what way the feeling resolved itself etc. I'm not saying men are completely dead inside, they too have feelings and talk about them, just usually in lesser words and within a shorter time frame. Sure, share the funny story of how your college roommate came home drunk and accidentally tried to pee in the kitchen bin (but don't elaborate on how a bad relationship with her uncle, and her deep seeded need for acceptance, is turning her into a possible alcoholic, even though she is, like, so pretty, and could totallygetaheafinlifeifshejuststandupblahblahblaaaa…).
3) If you are there as your partner's plus one, try to find an even balance between 'doting girlfriend' and 'socially-pleasant-what-a-lucky-guy-he-is vixen'. No, you don't need to fetch his drinks and stand quietly by his side, but you also don't need to over-compensate and tell naughty, embarrassing stories about him to his friends in order for them to like you.


text:
Home Local News Manitoba looking for feedback on easing COVID-19 restrictions
Manitoba looking for feedback on easing COVID-19 restrictions
The Manitoba government is seeking feedback from Manitobans on its plan to move forward to safely restore services and activities, while balancing the needs of the health care system, Premier Brian Pallister and Manitoba's chief provincial public health officer announced today.
"The current public health orders – which have been in place for over two months – were put in place to halt the spread of this deadly virus and save lives," said Pallister. "These orders are working, thanks to the willingness of Manitobans to follow them. At the advice of Dr. Roussin and our health care leaders, we are now in a position to consider reducing some restrictions and safely restoring our services and activities that so many Manitobans have sacrificed throughout this pandemic in order to protect themselves, their loved ones, and their community."
The province has launched a survey on EngageMB.ca and invites Manitobans to share feedback on their priorities for potential easing of the current COVID-19 restrictions. The survey asks questions about people's perspectives on the risk of the virus, COVID-19 vaccines and their comfort levels with different activities.
The survey also asks about priorities to safely restore services, including possible changes to gradually expand retail shopping, re-open barbershops and salons, gyms and fitness centres, non-regulated health professions, restaurants, faith-based and ceremonial gatherings and organized recreation and sport and possible increases to indoor, outdoor and household gathering sizes.
For more details on each option and to provide your feedback, visit EngageMB.ca/restartmb-pandemic-response-system.
This survey builds on prior steps taken to connect with Manitobans throughout the pandemic on public health orders, pandemic planning and more.
"While our test positivity rates, case numbers and hospitalizations are starting to come down and Manitobans are starting to get vaccinated, it is crucial that Manitobans continue to follow the fundamentals so we do not lose sight of the gains we have made these past few months," said Dr. Brent Roussin, chief provincial public health officer. "While we consider ways to carefully re-open Manitoba, we must always consider the needs of our health care system and limit the activities which we know cause the greatest risk."
Since April 2020, more than 304,000 participants have engaged with the Manitoba government on COVID-19 issues through telephone town halls, online surveys, public opinion research and other engagement opportunities on EngageMB.
"From the very beginning of this pandemic, our government has endeavoured to reach out directly to Manitobans and ask for their input, ideas and feedback on a variety of measures designed to keep Manitobans safe, while balancing the needs of our health care system and economy," Pallister added. "Our goal right now is to move forward, not backward. We want to create a sustainable path forward where our businesses and communities can reopen safely, and stay open. I look forward to hearing from Manitobans as we work together to build a heathier, safer, more prosperous future."
For more information on Manitoba's current pandemic response, visit www.manitoba.ca/COVID-19.
(News Release – Manitoba)
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In celebration of the HSPLS 2015 Children's Summer Reading Program, HouseMart Ace Hardware and HouseMart Ben Franklin Crafts will present "Super Hero Academy," a free event at two selected Kauai public libraries onTuesday, June 23 and Wednesday, July 1.
Keiki ages 5 and older, accompanied by a parent or caregiver, are invited to experience a special "Hardware Science" program featuring demonstrations, two interactive stations for exploring Hardware Science experiments such as making secret messages using lemons, and a super hero craft activity station to make-and-take a hero craft item. In this one-hour program, participants will receive a stamp card to record the completion of all three activities and receive a Super Hero Academy Graduation Certificate and a chance to enter a free prize drawing.
For more information about this event or about the 2015 HSPLS Children's, Teen, or Adult Summer Reading Programs, please visitwww.librarieshawaii.org/summerreading like us atwww.facebook.com/HSPLSHIgov, follow us on www.twitter.com/HSPLSHIgov, or call the hosting library.


Lenotti: Classic wines from Carda Lake and Verona!
In Italy, the Family Lenotti makes great wines that everyone knows! Currently, the farm is run by the Lenotti family.
La Rinaldini: How they offer great quality wines with passion and experience?
TENUTA COLPAOLA SRL: How they produce excellent wines in Italy?
Colpaola is Located in the small village of Braccano, on the hill behind Mount San Vicino, 650 metres from ASL.
Molinettocarrea:How Their Wines Speak For Itself?


The Legendary Pink Dots, "Live '85 - '88"
Compilation of live tracks taken from various performances.
Unlimited release available only via mail order directly from the Dots or from Beta-Lactam Ring Records, with copies burned as needed.
The track markings on the disc don't match with the songs themselves, and vary from copy to copy.
Bootleg copies exist and can be identified by the fact that they have a disc label (the official copies have no label) and covers printed on an inkjet printer (official copies have laser copied covers). In addition, some bootleg copies of this and the LIVE '89 disc are mislabelled as each other.


text:
The Family Tree of the American Gase, Moermond, Boes, Steigmeyer, Elchert, Nye (Ney) and Yost families
(R.A. Gase, editor. Click on a hyperlink for more information)
On August 8, 1817, the ship Hope, proceeding from Amsterdam, arrived at a quarantine station below Philadelphia, following 86 days at sea. Of the 346 passengers on board, 48 had died at sea and 46 more died in a wayside hospital. On September 9, 1817 the Hope finally arrived with its survivors in the Port. The passengers were transferred to the Lazeretto (the quarantine station) immediately after their arrival.
The story of the journey of the Ship Hope from Amsterdam to Philadelphia from May 8th until September 9th, 1817, written by Adrian Rudolf MÄRK (hat maker), one of the three leaders of the emigrant association from Aarau, in Pittsburgh, Pennsylvania, Aug. 12th 1818.
(Translation of the original publication in the Swiss Messenger N°50, 10 Dec 1818, p. 393, 394 and N°51, 17 Dec 1818, p. 401 - 405 made by Alfred Hilfliker).
"It was May 8th, 1817 when 350 passengers aboard the frigate "Hope" left Texel (a small island in the North Sea, close to Den Helder, the most northern city in the province of North Holland, the Netherlands, RAG).
We had a favorable wind that disappeared as soon as we reached the North Sea where we had to wait for the next 8 days. In the morning of May 16th with a good favorable wind we entered the British Channel and we could observe the coasts on both sides.
While we were waiting in the North Sea, to our regret, we had to state that our food provisions had melted down due to the long waiting in Texel so we asked the captain to land in England to buy food. The captain convinced us that we had enough food. The wind became strong and good so we left the Channel and found ourselves in the open ocean where we had to make the saddest experiences of which I will remember just the most important parts written in a compact form.
On June 4th we were reached by a ship from Morocco. The salute was with a cannonade then they set out a boat. Our captain armed crew and passengers with guns and swords and placed us in good order on deck to meet the visitor. Our welcome did impress the pirate so he made understand that it was not worth while to conquest our ship. They made a large half moon around our ship and sailed away.
At Whitsun we had the first and strongest storm that lasted two days and two nights. This storm arrived unexpectedly and we did risk loosing our masts. Nearly all our canvas sails and ropes have been torn down; the damage amounted to 300 florins
This accident had for us a high cost since the captain became fearful and as soon the wind became stronger he had the sails pulled down what delayed our journey considerably; the highest and the lateral sails disappeared or were only occasionally used.
Now we were 7 weeks on sea and expected hour after hour to see the new world when unexpectedly we saw the mountains of the Azores islands. How disappointed we all were to realize how far away our destination was this also because day after day our food was reduced. From the beginning the ratios were reduced to 2/3. We were close to a revolution, we wanted to force the captain to land in the island and buy food. The captain and the crew embraced arms and succeeded to bring the situation under control.
Now diseases began to expand; a bad nerve fever killed a family of the Black Forest group with the exception of a boy. Every day more passengers became sick. Mr. Huber from Zofingen, who was engaged as ship doctor, did not have the necessary medicine so that he could not bring any help. Some days later we met a ship coming from Liverpool. When they learned about our condition they offered us food and medicine. Still our captain refused the help and we had to see how they sailed away with the passengers dancing on deck while, due to hunger, we were not able to stand upright. So we remained alone with our afflictions.
At this time we were 8 weeks on sea, had no more meat, no butter, no cheese, no distillates, no vinegar, all was gone long ago.
Food melted away so instead of every day we received every 3 to 4 days half a measure of water. Bread was moldy and inedible; pees, barley and rice could not be cooked since the captain did not distribute enough wood. From now on an adult person did not receive more than a drinking glass of soup. Now people died like mosquito's; every day dead were thrown into the sea, at the end no more healthy people could be seen on board. In short: our misery was great. Still, it had to become even worse, for 30 barrels water had leaks and just two were full. From now on we did not receive any more water. If our omnipotent Father in heaven had not granted us rain to resurge, for sure we would not live any more. The on deck collected water had the smell of asphalt and rubbish and we had difficulty to retain it. Dying took overhand, no family was spared.
In the last two weeks we had again a 4 days' storm that pushed us back. We crossed sea grass four times, misery and hardship was around us, and all faces did express hardship and despair. Now also the sailors became sick except three of them; there was nobody able to work. What a forced terrible situation! On open sea without water, every body sick and unable to work during a storm! Two more days on sea and nobody would have survived.
But I will thank God almighty, He helped us during the hardship, He heard our supply for pity and mercy; He has seen our fear, misery and helped and rescued us in his omnipotence.
For five days we had constant, favorable and cool wind such we never had before and, on Aug. 3rd at night we did see a light in distance. The captain made hang a big lantern on top of the storm mast and, o what a joy, in about one hour we heard a boat coming toward us who brought us the pilot to guide us along the Delaware River up to Philadelphia. The pilot did not loose time; he had seen the faces with the death written on. He ordered right away to lift all the sails and traveled the same night a distance of 30 hours on the Delaware River. In the morning we could see both sides of the river. I am not able to describe my emotions. Who was able to reach the deck, unfortunately just a few did admire the dark green oak woods and on the ends beautiful meadows and plantations. On the Delaware the wind was not any more so strong as on the sea. The pilot got all sails mounted and extended the masts, now our ship was sailing wonderfully. It was a pleasure to see our ship with full sails and how the pilot tried to recuperate what our coward captain did loose since we left Amsterdam.
The two river sides are splendid, it was like standing in a "sight case", as I said just a few were able to appreciate this pleasure. Most were laying half dead in the ship's room; their organs were shocked if not, they would certainly had enjoyed the view. We arrived Aug. 5th at the quarantine station or Lazaretto. On Aug. 6th the sanitary service arrived, the captain denied the number of sick person, they saw with love to mankind our conditions and did communicate to Philadelphia that the healthiest of us looked like dead. We were nearly rejected; they said unanimously that so far no ship arrived in such a bad condition. On Aug. 7th we were allowed to land and reach the Lazaretto. The ones who recovered on the ship became again sick in the Lazaretto, many died here even with the useful help. We received very good food but some did lay sick for 4, 6 up to 8 weeks.
As soon as a certain number recovered they went to Philadelphia and were free at the condition they had paid their fare. Many tradesmen and farmers came to buy the one's who could not pay. These people are prevalently well treated by moderate work inclusive board and clothes.
Only, emigrants shall come without children if they are not in the position to pay. Seldom or never a complete family would be hired by one sire and how sad it is when one comes here, the other there and possibly, they will not see each other any more.
Considering what happened on sea the German shipping company paid all the costs of the Lazaretto. The captain was fired and got a fine of $ 1000.
The clothes we had on the ship as well as the bed wear were burned. My brother in Philadelphia became again sick and recovered on the journey up to Pittsburgh.
My wife, our three children and I were 4 weeks in the Lazaretto. After my wife recovered she shared a room with a woman who wanted to commit suicide so my wife got a shock and did underlie her weakened nature. Also my youngest child, a baby pending on mothers breast, died consequently. Myself and my two older children enjoy, thanks God, good health.
We remained in Philadelphia other three weeks then we bought a carriage and three horses and traveled up to Pittsburgh were we arrived Oct. 28th. This trip was very wearisome, the mountains, the sumps and the bad roads made the journey difficult and long. The one's who intend to travel to America do better if they sell everything at home and bring just what they do not want to miss; or let transport the belongings from Philadelphia to Pittsburgh for $ 8 to 10 for 100 lb.
Pittsburgh has about 250 houses and lies between two rivers, the Allegheny and Monongahela; below the city the two rivers join and are named Ohio.
Here as well as in Philadelphia you can find any kind of work. Steam, saw and flour mills, all with iron gears, are seen over all. Iron melting and foundries have efficient plants.
In Pittsburgh there are 7 well equipped glass factories. In Philadelphia I found a jute factory, it did not seem to be important. Here they do not wear clothes of jute, men wear usually textile, while women wear Camelot and silk, also the lovers of horse riding have their clothes made out of textile, and nearly everybody uses silken handkerchiefs.
The road from Philadelphia to Pittsburgh is full of transport carriages. Here they do supply the settlers of the western provinces. Home and field equipment are sold here by large stores. There are also many warehouses and commercial companies.
Every day ships leave Pittsburgh along the Ohio River loaded with every thinkable equipment.
In U.S. prevalently paper money circulates , fraud is common. Otherwise we see Spanish dollars, whole or split by ½, ¼, 1/8 and 1/16. At the moment gold loses value. Spanish and French are the best currencies.
Land can be bought all over for cheap prices, bush or farm land. Around Pittsburgh farm land costs, with house and barn, $ 15, 20 or 30 the acre.
My brother bought 160 acres at $ 1 (usually an acre costs $ 2) in Johns County and has departed with his family 4 weeks ago, traveling approximately 1500 English miles or 500 hours from Pittsburgh at the Mississippi river to the state of Indiana.
I do work with a hat producer and I do earn $ 10 a week. All workers are well paid; farm hands get $ 1 daily. Of course clothes are expensive, for example a hat costs up to $ 16, a pair shoes $ 2 to $ 6 a pair boots 12 to16 one yard textile $ 6 to 16. We do spend $ 3 to 4 a week, food is cheap, everyone who lives reasonably can be happy.
Still to provide for a family is no fun. Everyone, once here, and willing to work, finds easily his bread".
© 2019, R.A. Gase. E-mail:


These individual cakes are ideal for any occasion. They can be beautiful gifts, look magnificent on a stand for a wedding or can accentuate any theme for a party, and can be tailored to suit your requirements.
For those with a more adult taste why not go for rum and raison, tiamaria and coffee, irish cream liquer, or cranberries and cherry sourz.
The above ranges can be mixed and matched together to provide a variety on show, but different flavours can only be ordered in batches of 6.


text:
Mystic♡ would love your feedback! Got a few minutes to write a review?
Mystic♡ 1 story
9.His Past
Well, I used to live in an orphanage with my two lousy brothers named Mark and Jake. My parents had dropped me off over there when I was really young, and soon so were my brothers. We always stuck together and had a lot of fun time in the small orphanage with the other kids. I was the oldest, with Jack a year younger than me, and Mark being three years younger.
When I turned thirteen, we got a notice that the nearby town's highschool wanted to give free education to all the orphanage kids. Many of us were excited to study in a high school and not by some 'always furious' teacher from our orphanage. I was totally fine with this, and so were my brothers. So when we were dropped off at the school, we were happy, even though it looked odd with those weird historic designs. Some circles and random horizontal lines but didn't care. And just like the curious kids we were, my brothers and I dashed through the school doors, excited to finally explore a real highschool.
Once we entered high school, our principal who was shockingly pale, greeted us but gave off odd vibes which no one noticed except me. But none of us really cared about that since everyone was hyped up to explore the school.
Only later, once we started regularly attending the school did we notice that some of us were going missing. It happened slowly at first, one kid in a week or two but the number slowly started increasing. Some of us had complained to our orphanage nannies too, but they all dismissed it.
They did return, eventually, but they all returned differently. My best friend Cason who returned after five days had completely changed. He stopped talking to me and his skin color turned into an ashen color, just like our principal.
Which was strange, since we always used to spend time outside and we're tan. The ones who were not kidnapped-like me- noticed this and tried complaining to the other orphanage teachers only to get turned down. We weren't even able to go outside Scarenville since it was very far away from any nearby cities. Devastated, I told my brothers not to attend school to keep them safe. I knew something was wrong with the nannies and the school, so I didn't take risks and turned extra cautious.
The next day, I hopped on the school bus to hell. This time there were only five of us left who weren't kidnapped yet and we were well aware of the situation. Stuck between the strangers who once used to be our friends. One of them was Cason's sister who was the same age as me, with her blonde braids and honey brown eyes.
She looked anything rather than scared. Looking at her gave me some reassurance that I wasn't the only one, and I also knew very well that her older sister who was Cason's twin was also absent. Either she was kidnapped or stayed at the orphanage like my brothers. The bus rumbled and started moving forward. Anticipation pooled in my stomach. I was having some gut feeling that something big was going to happen today. And I was not wrong.
When we reached the school we found it completely dark. No open windows and no lights. And in the cold weather with fog, it felt like a danger zone.
Turn away and run.
My mind screamed, but seeing Cason's sister Cassie just walking forward made me feel stupid. Until I heard her scream just as she entered the dark halls of the school. The other three with me ran, including me. Behind me, I later heard laughter, but that didn't stop me. I could hear that someone was running behind us, the sound of footsteps following was audible and just then I heard a thud and a scream. One down.
I forced my legs to run faster as tears brimmed in my eyes. I heard another blood-curdling scream from another kid. I am the only one left. At that moment I felt so hopeless as I was capable of seeing whoever was behind me now speeding up quickly. While I almost was slowing down as my legs began to ache. I tried my hardest to run, only to later get pushed to the ground with a man with sharp claws, as fangs dug into me. After that, everything turned dark.
I later woke up on a bed with the other students. The principal held a champagne glass filled with a red drink. And for some reason, I was tempted to taste it. But kept me at bay.
"Do you know what happened to you all?" he asked in a monotone. His eyes empty and his lips crooked into a smirk, pleased to watch our confused expressions. My body automatically reacted with a snarl, surprising myself. I don't snarl, I was always a quite reserved kid in front of teachers, and even with friends; I was anything but a snarling boy.
I felt something sharp on my lip as I frowned in confusion, reaching out to touch it The principals' smirk grew. As I felt my canines being extra sharp-pointed. Fangs! My mind screamed. What happened to me? I looked at my skin and found them in an ashen color, just like the others.
"Confused, boy?" Someone called behind me and I immediately recognized my attacker's face which was coming into view.
"You?" I asked in both confusion and anger as my attacker's face became clear. Red eyes and long brown hair tied into a man bun.
"Yes, me," he replied with a smile, not reaching his eyes. It was later explained that I was now infected and would die in a few days if I didn't complete some transition of turning into a complete Vampire until I killed somebody.
It felt fake at first until I found Cassie drinking on her older sister's blood in the corner of our school. Her claws and fangs out and her mouth was covered in blood. As if sensing me snooping she glanced over her shoulder, "I am saving myself and my sister," she said in a stony tone.
"By killing her?" I asked in disbelief as my eyes rolled at the poor excuse.
"Cason bit me too! Now that we are infected, I find it's only better to live together now and accept being a Vampire."
I didn't hear the next part, as I walked away from her. How cruel? My mind wandered. I would never do that to my brothers! I stopped in my tracks. Cassie knows about my brothers and Cammie needs to bite someone too... But I was too late. My brothers were turned.
"That's my story," Damien finishes with a sigh. His eyes are lost in deep memory. But me being myself speaks. Breaking the moment of peace.
"Well, what about you? You had to bite someone too, right?" I ask and look at him nervously. He goes rigid for a second, but then his shoulders slump.
"I still haven't bitten anybody," he whispers so only I can hear it.
"But wouldn't you be dead then?" I whisper back. Maybe this is something he doesn't want other people to know. But how is he alive then?
"Look, back then I was truly scared and didn't want to hurt anyone or else the chain will keep on going... so I tried drinking my own blood, and turns out it worked! And I am not dead... just that I didn't fully transform..." He closes his eyes and tilts his head up.
The rest is up to my imagination; I guess. Since he doesn't say anything. So rather than turning into a Vampire, he became a half Vampire. I don't really know whether that's a good thing or a bad thing.
There is a moment of silence. In the darkroom, only mine and Damien's soft breathing is audible. It's so soft, one could imagine he isn't breathing, but I can feel it. I put my hand on top of his and continue in my most comforting voice. "And?"
He goes rigid again, but this time he doesn't calm down instead, he stands up. Almost too quickly and removes my hand. Oh, no wrong move. "Have I asked you to tell me every detail of your past?" His voice sounds harsh. And he doesn't turn to look at me.
"No..." I trail off.
"Then this is all you need to know for now," he says and steps towards the door. I stand too and try to reach for him but then stop. It's of no use.
"Look... I am sorry if I said something wrong," I stutter but he just shakes his head.
"No, it's nothing." His voice calmer now, "Go to your room, you must be tired." And with that, he leaves.
I stand there foolishly, but my mind is filled with thoughts. I know he didn't explain everything, and the major stuff is what actually happened after he was turned into a half Vampire. But for now, I won't pressurize him to tell me everything. He told me his secret and I am going to respect that for now.
The hallway is quiet and only my footsteps are heard as I go back into my room. Once I reach my room, I lock it and switch on the lights, only to see an enormous mess. The lamps and glasses are broken. The TV is half shattered and the bed sheets are a bit burnt. Great, where do I sleep now?
10. 9.His Past
2 1. Scarenville
3 2. Scarenville Highschool
4 3. He is a Vampire
5 4. The note
6 5. Surprise
7 6. Masquerade Party
8 7. Spy? I am not a spy!
9 8.Her Past
10 9.His Past
11 10. Damiens lies
12 11. Agents
13 12. His bite
14 13. My fear
15 14. Damien
16 15. Escaped
17 16. Caught
18 17. The records
19 18. Why can't I?
20 19. Pain
21 20. Secrets unravelled
22 21. Tears of misery
23 22. Leaving for good
24 23. Rain and Love
25 24. Graveyard
26 25.The truth
27 26. The betrayal
28 27. Green eyes
29 28. Camouflage
30 29. Killing a Vampire:101
31 30. Mark
32 31. The attack
33 32. The portrait
34 33. Mark's true colours
35 34. What have I done?
36 30.Mark
39 33. Mark's True colors
41 35. Revenge
42 36. The rescue
43 37. Over
44 38. A New Beginning(rose)
45 39. A New Beginning(damien)
46 Epilogue
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EmbASP-Python v7.1.0

parsers

datalog

datalog_parser_base

DatalogGrammarParser

DatalogGrammarParser

Predicate_atomContext

Public Member Functions |
Public Attributes |
List of all members

parsers.datalog.datalog_parser_base.DatalogGrammarParser.DatalogGrammarParser.Predicate_atomContext Class Reference

Inheritance diagram for parsers.datalog.datalog_parser_base.DatalogGrammarParser.DatalogGrammarParser.Predicate_atomContext:

Public Member Functions

def 	__init__ (self, parser, ParserRuleContext parent=None, int invokingState=-1)

def 	IDENTIFIER (self)

def 	term (self, int i=None)

def 	getRuleIndex (self)

def 	accept (self, ParseTreeVisitor visitor)

Public Attributes

 	parser

Constructor & Destructor Documentation

◆ __init__()

          def parsers.datalog.datalog_parser_base.DatalogGrammarParser.DatalogGrammarParser.Predicate_atomContext.__init__
          (

          self,

          parser,

          ParserRuleContext
          parent = None,

          int
          invokingState = -1

          )

Member Function Documentation

◆ accept()

          def parsers.datalog.datalog_parser_base.DatalogGrammarParser.DatalogGrammarParser.Predicate_atomContext.accept
          (

          self,

          ParseTreeVisitor
          visitor

          )

◆ getRuleIndex()

          def parsers.datalog.datalog_parser_base.DatalogGrammarParser.DatalogGrammarParser.Predicate_atomContext.getRuleIndex
          (

          self	)

◆ IDENTIFIER()

          def parsers.datalog.datalog_parser_base.DatalogGrammarParser.DatalogGrammarParser.Predicate_atomContext.IDENTIFIER
          (

          self	)

◆ term()

          def parsers.datalog.datalog_parser_base.DatalogGrammarParser.DatalogGrammarParser.Predicate_atomContext.term
          (

          self,

          int
          i = None

          )

Member Data Documentation

◆ parser

          parsers.datalog.datalog_parser_base.DatalogGrammarParser.DatalogGrammarParser.Predicate_atomContext.parser

The documentation for this class was generated from the following file:

embasp-python/parsers/datalog/datalog_parser_base/DatalogGrammarParser.py

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