text:
Q: Verifying Email Confirmation I'm having a problem getting users accounts to verify. I get it to insert data and then send out a confirmation link but when it's clicked in the email it doesn't update the 'active' row from 0 to 1. I'm been messing with this all night and it's probably something simple but either way if anyone can help I'd greatly appreciate it.
Also if anyone could provide any tips on making this injection proof I'd also be very happy. Thanks!
<?php

require ('classes/class.db.php');
require ('classes/class.pass.php');

try {

if(isset($_GET['email']) && !empty($_GET['email']) AND isset($_GET['email_hash']) && !empty($_GET['email_hash'])){
    // Verify data
    $search = "SELECT email, email_hash, active FROM users WHERE email='".$email."' AND hash='".$email_hash."' AND active='0'";
    $match = $db->num_rows( $query );

    if($match > 0){

    $stmt = $db->prepare('UPDATE users (active) VALUES (:active) WHERE active = 0');
    $status = $stmt->execute(array(
    ':active' => 1));

        if( $status )
        {
            echo '
Your account has been activated, you can now login
';
        }
    }

}else{
    echo '
Your account is already activated
';
}

} catch (PDOException $e) {
        die($e->getMessage());
    }

?>

UPDATE #1
Tried what Akam suggested but still am getting some errors. Here is what I have for my statement.
$stmt = $db->prepare("UPDATE users SET active ='1' where active = '0' and email=:email AND email_hash=:email_hash");
$status = $stmt->execute(array(
':email' => $_GET['email'],
':email_hash' => $_GET['email_hash']
));

UPDATE #2
Seems like the problem is $_GET['email_hash'] which can't be echoed or stored in a variable. It won't take the random hash string from the signup.php page and carry it over to the verify.php page, but the email address carries over perfectly fine. I'm a bit confused and would love for someone to clarify this for me. Thanks.
UPDATE #3
Problem was as simple as turning $_GET['email_hash'] to $_GET['hash'] . Thanks again!

A: You can also do all by one query, no need to first query if you write same conditions in the update:
"UPDATE users SET active ='1' where active = '0' and email=:email AND hash=:email"

A: Your UPDATE query contains a syntax error. Try changing the query to
$stmt = $db->prepare('UPDATE users SET active=:active WHERE active=0 AND email=:email AND email_hash=:email_hash');

And then include $email and $email_hash in your associative array during statement execution.
Just as a side note, calling isset($var) && !empty($var) is roughly equivalent to writing !empty($var). As per the documentation, because
empty($var)

is congruent to
!isset($var) || $var == false,

it follows that !empty($var) is congruent to isset($var) && $var != false.

redpajama_set_name: RedPajamaStackExchange


Different cultures from around the world have described emotions and feelings you never thought about. In this article, you will learn some of them.
We live in an age where science is at its peak and we are making more amazing discoveries than ever before. This is especially true of neuroscience, which in recent years has advanced dramatically.
Scientists have conducted extensive research into brain-imaging and can now locate with exact precision where in our brains certain emotions and feelings originate from.
One such researcher is Tiffany Watt-Smith from the Centre for the History of the Emotions and Queen Mary University in London.
In fact, Smith has published a fascinating and eye-opening book on this topic titled 'The Book of Human Emotions'. In this book, she gives 154 words used in different cultures from around the world that describe very specific emotions and feelings that either was impossible for you to describe before or perhaps you never even realised you had them.
According to Smith, naming a feeling makes it more manageable to deal with.
Here is a selection of ten of those words about emotions and feelings.
This is a word used by the Dusun Baguk people of Indonesia, and according to Smith it is described as "the sudden experience of feeling constricted, inferior and awkward around people of higher status." Although we may view this as a negative feeling, it is in fact perceived by this culture as good manners and as an appropriate sign of respect.
This is a Finnish word describing feeling homesickness for a place you have never been to. It can also be described as an inherent wanderlust, a "craving for a distant land" – a feeling that will resonate with any travel lover.
A literal translation from German meaning "gate-closing panic," this word perfectly describes the sensation that time is running out, or that life is passing you by.
This is a fun and playful word for teasing or annoying someone on purpose, to see how far you can go until they snap. Akin to pushing someone's buttons, many of us with siblings will relate to this.
Literal French for decountrification (being without a country) and the feeling of being an outsider. The actual emotion itself is a "kind of giddiness, only ever felt when far away from home" which can sometimes make people do crazy and 'yolo' antics that they may not be so inclined to do back at home.
Your article was very interesting and I would like to speak with you, if possible!
Mary Kingsley: U look cute & I like to talk to cute girls who speak their minds on interesting things.


Our auto locksmiths are competent to work on the majority of vehicles to include cars, vans, lorry's and motorcycles, although there are certain models which may not be covered in this instant, never the less, we do continually endeavor to maximise our expertise in the industry and provide support to cover an extensive range of vehicles forever increasing it's always advised to call or e-mail us prior to check your exact vehicle make and model, we will provide you with a quick turnaround on the information required and are ready to supply you with a free no-obligation quote there and then. Lets have a look at how thatcham categorises vehicle security and how this relates to alarm systems. Aspect.co.uk is expanding to areas outside of london enter your postcode to see if we cover your area. Valton mobile locksmiths are lock specialists serving paisley and surrounding areas. We are based in exeter, supplying and fitting accessories to light commercial vehicles in the local area. The first and most common reason for a call out is to get into a locked car when the owner does not have the keys this can happen to anyone, at any time and can be a costly and time consuming process if you do not have a spare key to hand.
We provide locksmith services in shepton mallet, frome, wells, wincanton, shaftesbury, warminster, westbury and the surrounding villages. That's it you now have access to the rest of the door in order to put the panel back on, just follow these directions in reverse order. This course is the latest addition to the matrix portfolio and can provide locksmiths with a highly lucrative income with a detailed step by step approach and practical demonstrations of specialist lock fitting techniques to vehicles, we can assure you of an illuminating, intensive and yet very enjoyable day. W x d x h: 16 x 53 x 1702mm fixings supplied adjustable max height 2m weight 2.525kg. Auto, commercial and domestic locksmith work is undertaken in stoke on trent and throughout the staffordshire & the west midlands , no job is too big or small and we have a long list of local clients that can vouch for our exceptional locksmith service. The housing market is dominated by upvc doors and windows now and we have been making this our main area for repairs for 20 years in fact, we were quick to realise that when parts and spares are becoming in short supply that there is a need to buy up all stock available our vast stock holding is now enabling us to repair doors where other locksmiths can not! Your secure locksmiths nottingham are able to now introduce to you the new abus codeloxx lc the new abus codeloxx allows you to have a 4-8 digit combination and up to 50 different codes the abus codeloxx is ideal for homes and businesses access is granted by either code or access key. Bryans lock services provide locksmith services across oxfordshire we operate in areas including abingdon, oxford, harwell, wantage and wallingford. A skilled locksmith birmingham assistant will always be ready, and the readiness is what provides the quick response being ready means being prepared, vehicle packed, training done and of course tools loaded together with the spare parts to be able to deal with any situation a locksmith birmingham situation can bring up fast and easy stress relief in the most pressured lockout situations you can imagine. Whether you've lost your keys or find out the door lock of your office has been changed while you were on holiday, you can always count on us. With over 15 years of experience in property maintenance, i offer a wide range of services my aim is 100% customer satisfaction by delivering a top quality service everytime i pride myself with my reliability.
I let you know about new posts like once every 2 weeks. For your convenience, please complete our online enquiry form, we'll. Up to 3 tradesmen can provide a quote, but on average you'll get 1-2. Provide year round, reliable and professional locksmith services for landlords, estate agents, letting agents, rented business premises and other commercial customers, such as. Other available pastillas para impotencia security modifications include. Buckle and jones locksmiths offer a quick response so you are not left standing on your door step. First class locksmith work to homes and businesses a fair price is what you need when you're locked out go direct with a local locksmith birmingham for that personal customer care and service choose a locksmith who can access quickly with no damage at the best price any lock, any door, upvc and more! non-destructive entry and all lock out services provided. In order to produce a spare key or programme a remote into your vehicle, we often need a security pin code in other words the immobiliser code if you do not have this, in most cases we can obtain it for you through our machines or main dealers. When it comes to changing locks at home, whether it's a standard yale lock or a upvc door lock replacement, our professionals are highly skilled in the area and have the necessary knowledge and tools to carry out a top quality service. Besides the standard keys used in older model cars without central locking, your vehicle keys may be specialised battery key fobs, remote keys or contain electronic chips no matter what type of key access you have, ghi locksmiths emergency services will be able to help if disaster strikes.


I have created a group in Facebook called "SAVE MALAYSIAN SCHOOL SPORTS AND MALAYSIAN SPORT FUTURE. Based on a posting from this Blog, there are 2,959.092 Primary School and 2,331,901 Secondary School Children in the country and it sums up to 5,445,675 school going children. Add that to one half of the parents, which would be another 2,722,832 and we will come to a grand total of 8,125,440, which is 30% of the total of 27 million population of Malaysia. Lets say that only 40% of these 8,013,815 millions have access to computer, and out of that 40% have Facebook account. Can anyone tell me the answer?????Yes………correct…the answer is 3,205,526 school going children and one half of the parent. If we can hit 500,000 members in this group by end of February, literally we would be sending signals to the Ministry of Education and the Ministry of Youth and Sports that they have failed their KPI. Isn't KPI what our Prime Minister wants? If we manage to hit ONE MILLION members by end of February 2010, these people better empty their table and leave the Ministry. You have been voted out of your job, by the PEOPLE!To all journalist, blogger, readers of the Blog and all TRUE Malaysians, please join the group, If you do not have a Facebook account, create one but please join us!!!!


It's sort of strange being back in Arizona. We never thought we'd live here again and it's comforting to move to a place that is somewhat familiar. I remember saying that I wouldn't mind living here again... and here we are now.
I took this picture almost 3 years ago. This weekend we had dinner here.
When we lived here in 2009, the kids and I were just visiting. We stayed for several weeks so that we could see Jason before he left for Iraq. There was sort of a cloud hanging over us, although we tried to really enjoy every minute that we had together. The kids had no idea what was coming.
This time, there is no looming deployment. We are just... here. Living. Enjoying our time here, knowing that another move is coming next year. It's kinda nice!
We had lunch in Tombstone this weekend. As I watched Sarah and Joshua sitting on this bench, it was strangely familiar.
We walked the same streets and stopped in the same places. But this time we have a smaller stroller... and bigger kids!
We've downgraded our stroller. Finally! Although, Leila and Sarah were both sitting in the double stroller after a long day of walking. It's harder pushing four kids in a double than it is pushing 5 kids in a quad.
We visited one of our favorite spots this weekend. There is a beautiful river just outside of town and the kids love to stand high on the banks of the river and toss pebbles into it.
There is just something really special about watching siblings hold hands. Don't you think?
Even though it's 70 degrees or more at our house, there's still a light dusting of snow on the mountains. Love that!
It's hard to believe that we have only been here for 2 months now. It is already feeling like home. I guess that's a good thing!


text:
Intellectual Center — Scientific library named after E.I. Ovsyankin
Museum of the history of NArFU
Engaging Science museum
е-Resources
Reading the Arctic
Arctic Explorers
Traces of Polar Heroes
Spor etter polarhelter
[link] => /index.php?lang=en
[name] => е-Resources
[link] => /index.php?option=com_content&view=article&id=761&Itemid=671&lang=en
Портал интеллектуального центра - научной библиотеки е-Resources
We have reference service, several e-resources rooms and reading rooms in our buildings, where you can:
view items from our collections,
access e-resources including our e-catalogues, digital library, remote subscription resources and open access databases,
use search and discovery tools.
Reference Service:
Number of seats: 10
How to find us: Smolny Buyan str., 1st fl. room 104
Opening hours: Mon—Fri: 8:00–19:00 Sat: 9:00–16:00
Tel.: +7 (8182) 21 61 00 (2314)
Here you can:
use our computers and Internet for free,
access e-resources including our e-catalogues, digital library, remote subscription resources,
access open resources on the Library`s web-site,
access to the Card Catalogues,
refer to a bibliographer for operational advice on searching and selecting sources,
retrieve information on the working hours of the library and forthcoming events,
use own carriers, such as disks and flash memory sticks,
plug personal lap-tops.
E-Resources Room:
How to find us: Smolny Buyan str., 2nd fl. room 308
use library computers and software,
get assistance from our qualified librarians,
view CDs and DVDs containing digital items from the stock of the department,
E-Resources Room in Severodvinsk:
How to find us: Karl Marx str., room 211
Tel.: +7 (8184) 53 95 71.
At our Copy Service Desk, you can photocopy, scan and print copies.
Wi-Fi is provided in all rooms.
Rules for using resources:
e-resources are only for study and science,
documents are not for commercial use,
downloading of some full texts of books and magazines is prohibited (see add. restrictions).
REMOTE SUBSCRIPTION AND LIMITED ACCESS RESOURCES
Dimensions base of more than 89 million of academic papers and more than 860 million of abstracts
Electronic Journals Library more than 36 thousand terms from all scientific fields
Nano.Nature.com scientific solutions for nanoscience
Nature leading weekly multidiscipline scientific journal
Neicon archive of scientific journals
Orbit Intelligence combines about 100 databases aimed for patent specialists, designers and wide range of researchers
Polpred.com millions of articles on various topics
Science Direct the leading platform of peer-reviewed literature that helps you move your research forward
Scopus (SciVerse) the biggest united abstract database that indexes more than 19000 names of science, technical, medical journals from about 4000 publichers
Springer publications made here are considered to be authoritative and esteemed
Taylor-Francis includes about 2600 journals on various scientific topics
Web of Science the most authoritative analytical and abstract database of journal articles
Wiley one of the oldest academic publishers in the world
zbMATH abstract database on fundamental and applied math
1stWebDesigner resource about web design
ACM Queue the ACM's magazine for practicing software engineers
Arctic Portal the portal about the Arctic
arXiv.org free distribution service and an open archive for scholarly articles in the fields of physics, mathematics, computer science, quantitative biology, quantitative finance, statistics, electrical engineering and systems science, and economics
BASE: Bielefeld Academic Search Engine one of the world's most voluminous search engines especially for academic web resources. BASE provides more than 150 million documents from more than 7,000 sources. You can access the full texts of about 60% of the indexed documents for free (Open Access) BASE is operated by Bielefeld University Library
Biomed Central has more than 300 peer-reviewed journals in biomedicine, medicine and natural sciences
ChemSpider free chemical database
CiNii database service which can be searched with academic information of articles, Books, Journals & Dissertations. It is available free of charge for anyone
Codrops web design and development blog that publishes articles and tutorials about the latest web trends, techniques and new possibilities
CORE the world's largest collection of open access research papers
DART-EUROPE has more than 500,000 dissertations in English and other European languages. The DART-Europe database contains the work of scientists from 600 universities in 28 European countries
De Gruyter Open has about 400 scientific journals in all main disciplines
Dialnet regularly updated database contains more than 40,000 doctoral theses and scientific articles from leading universities in Spain in Spanish and other European languages. Theses are grouped by University
Directory of Open Access Books (DOAB) contains 3000 books provided by 122 scientific publishers
Directory of Open Access Journals (DOAJ) independent database contains ca. 12000 open access journals covering all areas of science, technology, medicine, social science and humanities
EBSCO Open Dissertations includes the content from American Doctoral Dissertations. It is a free database with records for more than 1.2 million electronic theses and dissertations from around the world
Europeana digital library, which aims to provide access to scanned pages of books reflecting various aspects of European culture
Google Scholar (Академия Google) free search engine for full-text scientific publications of all formats and disciplines
IDEAS: Economics and Finance Research extensive bibliographic database on economics and finance compiled by the Federal Reserve Bank of Saint Louis, Missouri, in the United States
InTech collection more than 4,900 peer-reviewed Open Access books
IOP Institute of Physics represents sections on physical science, academic publications, educational resources, career options and multimedia resources
JSTOR — Open Access more than 6,000 open access ebooks from 85+ publishers, including Brill, Cornell University Press, De Gruyter, and University of California Press, are now available at no cost to libraries or users
LibrarianChick everything from books to quizzes and videos here, includes directories on open source and open educational resources. Includes books, lectures and podcasts on math, arts, history, geography etc
NIST Digital Library of Mathematical Functions online project at the National Institute of Standards and Technology (NIST) to develop a major resource of mathematical reference data for special functions and their applications. It is intended as an update of Abramowitz's and Stegun's Handbook of Mathematical Functions (A&S)
Noupe articles and news for designers and web developers about CSS, web design, graphics, typography, and much more
OAPEN online library and publication platform
OER Commons contains over 40,000 open educational resources from elementary school through to higher education
OpenDOAR global Directory of Open Access Repositories
Open Textbook Library textbooks that have been funded, published, and licensed to be freely used, adapted, and distributed. These books have been reviewed by faculty from a variety of colleges and universities to assess their quality. The library currently includes 781 textbooks, with more being added all the time
ORBIT lesson ideas (with supporting materials) in mathematics and science, for primary and secondary, as well as resources aimed at teacher education
PLOS collection of scientific journals in open access
PQDT Open open access dissertations and theses
PubMed contains more than 30 million citations for biomedical literature from MEDLINE, natural science journals, and online books. Quotes may contain links to full-text content from the PubMed Central and publisher websites
ResearchGate access to more than 135 million pages of publications
SAGE online platform hosts SAGE's prestigious and highly cited journals and represents one of the largest lists in the social sciences
Social Science Open Access Repository (SSOAR) database specializing in scholarly articles from the social sciences which is freely accessible on the Internet. SSOAR is a full-text server, and Internet users can access full-text versions of documents free of charge and without prior registration. SSOAR offers authors the opportunity to self-archive their texts, to make them freely accessible and, by so doing, to increase the visibility and reach of their work
The World Atlas of Language Structures large database of structural (phonological, grammatical, lexical) properties of languages gathered from descriptive materials (such as reference grammars) by a team of 55 authors
Tubebooks.org technical books online
Ulkit is A lightweight and modular front-end framework for developing fast and powerful web interfaces
UNdata web-based data service that contains statistical materials on agriculture, crime, communication, development assistance, education, energy, environment, finance, gender, health, labour market, manufacturing, national accounts, population and migration, science and technology, tourism, transport and trade
Academic Earth over 1,500 video lectures from MIT, Stanford, Berkeley, Harvard, Princeton, and Yale. Allows to select a degree, a category and a subject before the search
African Virtual University has numerous modules on subjects in English, French, and Portuguese. Top modules of the library are on applied computer science, online journal publications, policy briefs and teacher education
Coursera works with universities and other organizations to offer online courses, specializations, and degrees in a variety of subjects, such as engineering, data science, machine learning, mathematics, business, computer science, digital marketing, humanities, medicine, biology, social sciences, and others
Ed.ex access 2500+ Online Courses from 140 Institutions. edX is the trusted platform for education and learning. Founded by Harvard and MIT, edX is home to more than 20 million learners, the majority of top-ranked universities in the world and industry-leading companies
France université numérique FUN is the French national platform to promote the use of massive open online courses
MOOCs MOOCs — Massive Open Online Courses — provide one of the most innovative forms of learning. OpenHPI courses offer Internet knowledge through learning videos, interactive self-tests, tutorials, practical exercises and homework
OEDb is a comprehensive online education directory with a categorized list of over 8,000 free online college courses from well-known universities
OpenLearn educational website. It is the UK's Open University's contribution to the Open educational resources (OER) project and the home of free, open learning from The Open University
Bing web search engine owned and operated by Microsoft. The service has its origins in Microsoft's previous search engines: MSN Search, Windows Live Search and later Live Search. Bing provides a variety of search services, including web, video, image and map search products
Dogpile find the best of all the major search engines with Dogpile, an engine that returns results from Google, Yahoo!, and Bing, with categories including Web, Images, Video, and even White Pages
Duckduckgo a search engine that emphasizes ensuring user privacy and avoiding the filter bubble of personalized search results. DuckDuckGo is focused on delivering the best results and generates results from over 400 sources, including key crowdsourcing sites like Wikipedia, as well as other search engines like Bing, Yahoo !, Yandex and Yummly
Excite web portal launched in 1995 that provides a variety of content including news and weather, a metasearch engine, a web-based email, instant messaging, stock quotes, and a customizable user homepage
Google the world's largest Internet search engine owned by Google Inc. Founded in 1998 by Larry Page and Sergey Brin. The first most popular system processes 41 billion 345 million requests per month (indexes more than 25 billion web pages, supports searching documents in PDF, RTF, PostScript, Microsoft Word, Microsoft Excel, Microsoft PowerPoint and others
Hotbot was launched in May 1996 by HotWired, a tool providing search results served by the Inktomi database. HotBot was launched using a «new links» strategy of marketing, claiming to index the entire web and its website stated it being the «most complete Web index online» with 54 million documents.Its colorful interface and impressive features (e.g. being able to search with any entered words, or an entire phrase) drew acclaim and popularity
Metacrawler makes it easy to «search the search engines,» returning results from Google, Yahoo!, and Bing
Yahoo is a search engine owned by Yahoo, it is the fifth largest search engine in the United States in terms of volume of searches, after its competitors Google and Bing
Last Updated on 07 August 2020
Arctic-Fund
The Website of E.I. Ovsyankin
NArFU named after M.V. Lomonosov
Северный (Арктический) федеральный университет имени М.В. Ломоносова. © 2023 All Rights Reserved

redpajama_set_name: RedPajamaCommonCrawl


Morrison Government cabinet minister Peter Dutton is expected to arrive back in Australia later today after abandoning plans to run in the leadership challenge to UK Prime Minister Theresa May.
Accompanied by his campaign manager and numbers man Senator Mathias Cormann, Mr Dutton flew to London yesterday to announce he would be a contender in any vote on Mrs May's job.
Mr Dutton called a news conference at 10 Downing Street to outline his intentions.
"Mathias has assured me he has learned from the mistakes my team made back in August when I challenged Malcolm Turnbull," Mr Dutton said.
A puzzled British media pack asked Mr Dutton if he was confident of having the numbers in any ballot of the 315 UK Conservative Party MPs given he was not elected to the House of Commons.
They also pointed out he would need to have British citizenship which meant he could not sit in the Australian Parliament on his return.
However, Senator Cormann had not been available to address the concerns as he had departed very quickly in a London cab heading to Heathrow Airport.
Posted in Australia, Politics, United Kingdom and tagged 10 Downing Street, Conservative Party, Matthias Cormann, Peter Dutton, Theresa May. Bookmark the permalink.


text:
1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women
Chandrasekhar Thota, Ramkumar Menon, Stephen J. Fortunato, Lina Brou, Jae Eun Lee, Ayman Al-Hendy
Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.
Reproductive Sciences
Ergocalciferols
Avitaminosis
Radioimmunoassay
1,25-dihydroxyvitamin D
1,25-(OH)2 vitamin D
25-(OH) vitamin D
Caucasians
preterm birth
serum levels
Thota, C., Menon, R., Fortunato, S. J., Brou, L., Lee, J. E., & Al-Hendy, A. (2014). 1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women. Reproductive Sciences, 21(2), 244-250. https://doi.org/10.1177/1933719113493513
1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women. / Thota, Chandrasekhar; Menon, Ramkumar; Fortunato, Stephen J.; Brou, Lina; Lee, Jae Eun; Al-Hendy, Ayman.
In: Reproductive Sciences, Vol. 21, No. 2, 01.01.2014, p. 244-250.
Thota, C, Menon, R, Fortunato, SJ, Brou, L, Lee, JE & Al-Hendy, A 2014, '1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women', Reproductive Sciences, vol. 21, no. 2, pp. 244-250. https://doi.org/10.1177/1933719113493513
Thota C, Menon R, Fortunato SJ, Brou L, Lee JE, Al-Hendy A. 1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women. Reproductive Sciences. 2014 Jan 1;21(2):244-250. https://doi.org/10.1177/1933719113493513
Thota, Chandrasekhar ; Menon, Ramkumar ; Fortunato, Stephen J. ; Brou, Lina ; Lee, Jae Eun ; Al-Hendy, Ayman. / 1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women. In: Reproductive Sciences. 2014 ; Vol. 21, No. 2. pp. 244-250.
@article{bbeaab7b82e74c73a10f7d4a21c83e97,
title = "1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women",
abstract = "Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.",
keywords = "1,25-(OH)2 vitamin D, 25-(OH) vitamin D, African Americans, Caucasians, preterm birth, serum levels",
author = "Chandrasekhar Thota and Ramkumar Menon and Fortunato, {Stephen J.} and Lina Brou and Lee, {Jae Eun} and Ayman Al-Hendy",
journal = "Reproductive Sciences",
publisher = "SAGE Publications Inc.",
T1 - 1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women
AU - Thota, Chandrasekhar
AU - Menon, Ramkumar
AU - Fortunato, Stephen J.
AU - Brou, Lina
AU - Lee, Jae Eun
AU - Al-Hendy, Ayman
N2 - Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.
AB - Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.
KW - 1,25-(OH)2 vitamin D
KW - 25-(OH) vitamin D
KW - African Americans
KW - Caucasians
KW - preterm birth
KW - serum levels
JO - Reproductive Sciences
JF - Reproductive Sciences


Samsung galaxy tab 3 lite 8gb, wi-fi, 7in - white. Samsung galaxy tab 3 8gb in excellent condition no scratches or dents includes cover.
8.0 Black 16GB Galaxy Tab E wi-fi and 3G. received this 2nd tab as a gift, used by family member this past week in consideration of purchasing. tablette samsung galaxy tab e never opened .
Samsung Galaxy Tab 3 16GB Wifi Tablet. écran de 8'' vient avec chargeur. BRAND NEW PREMIUM galaxy tab 3 for sale. Available for just 214.33 . So Grab yourself a bargain. Any question Please ask! Thanks for Looking.
Check out these interesting ads related to "galaxy tab 3"
Samsung galaxy tablet s3 9.7", black. Écran de 8'' vient avec chargeur. perfectly working tablet samsung galaxy tab 3 for sale it's 7inch great condition.
Selling brand new galaxy tab e. 7" tft display capacitive multi-touchscreen . Used galaxy tab 3 for sale. Have a close look on the photos to have right idea of condition. Available for just 100.0 .
- Samsung tab 3 - Like brand new (and with the samsung galaxy tab 3 and microsoft linx tablet . "Buyers can leave us a stars positive feedback to let us know that they have received, tested our item and satisfied with it"
Great condition. these tablets work great and will have the service cancelled and ready to go. Samsung Galaxy Tab 3 (7 inch) , all good shape. Available for just 100 . So Grab yourself a bargain. Any question Please ask!
Samsung galaxy tab s3 sm-t820nzkaxac quad core. Excellent close to new shape best offer takes it.
Samsung Galaxy Tab S 8.5" (SM-T705W) -1 tablette samsung galaxy tab 3 -1 carte micro sd de 8go -1 fil de charge négociable. works well, does not come with a charger.
Samsung galaxy tablet s3 9.7", silver. Purchased in the uk a couple years ago. "Its fast, easy and secure buyer protection i offer free shipping on all items"
Samsung Galaxy Tab S3 32GB 100% GUARANTEED brand new AUTHENTIC. Available for just 469.99 . Any question Please ask!
samsung galaxy s5 and samsung tab 3 in excellent still has original factory protection sticker on back of tablet. works well, does not come with a charger.
galaxy tab 3 In very good condition !! Have a close look on the photos to have right idea of condition. Offered at 150.00.


text:
Crella is a genus of marine demosponges in the family Crellidae.

Subgenera
 Crella (Crella) Gray, 1867
 Crella (Grayella) Carter, 1869
 Crella (Pytheas) Topsent, 1890
 Crella (Yvesia) Topsent, 1890

Species
 Crella acanthosclera (Lévi & Lévi, 1983)
 Crella aceratospiculum (Carter, 1880)
 Crella affinis (Brøndsted, 1924)
 Crella akraleitae (Brøndsted, 1932)
 Crella alba (Vacelet, 1969)
 Crella albula (Bowerbank, 1866)
 Crella atra (Topsent, 1890)
 Crella aurantiaca Bertolino, Calcinai & Pansini, 2009
 Crella basispinosa Burton, 1931
 Crella beglingerae van Soest, 2009
 Crella brasiliensis Moraes, 2011
 Crella caespes (Ehlers, 1870)
 Crella carnosa (Topsent, 1904)
 Crella carteri Van Soest & Hooper, 2020
 Crella chelifera van Soest, 1984
 Crella commensalis Whitelegge, 1906
 Crella compressa (Carter, 1886)
 Crella crassa (Hentschel, 1914)
 Crella cyathophora Carter, 1869
 Crella digitifera (Lévi, 1959)
 Crella dispar (Topsent, 1927)
 Crella donsi Burton, 1931
 Crella elegans (Schmidt, 1862)
 Crella erecta (Lévi, 1963)
 Crella fallax (Topsent, 1890)
 Crella fristedti (Dendy, 1924)
 Crella fusifera Sarà, 1969
 Crella gelida (Lundbeck, 1910)
 Crella gerzensteini (Swartschevsky, 1906)
 Crella gracilis (Alander, 1942)
 Crella guernei (Topsent, 1890)
 Crella hanseni (Topsent, 1890)
 Crella hennequinae Goodwin, Berman & Hendry, 2019
 Crella incrustans (Carter, 1885)
 Crella jaegerskioeldi Alander, 1937
 Crella linguifera (Topsent, 1890)
 Crella mammillata (Arnesen, 1903)
 Crella mollior Topsent, 1925
 Crella nodulosa Sarà, 1959
 Crella novaezealandiae (Bergquist & Fromont, 1988)
 Crella papillata (Lévi, 1958)
 Crella papillosa (Schmidt, 1870)
 Crella pertusa (Topsent, 1890)
 Crella plana Picton & Goodwin, 2007
 Crella polymastia (Thiele, 1903)
 Crella pulvinar (Schmidt, 1868)
 Crella pyrula (Carter, 1876)
 Crella richardi (Topsent, 1890)
 Crella ridleyi (Topsent, 1890)
 Crella rosea (Topsent, 1892)
 Crella rubiginosa (Schmidt, 1862)
 Crella schottlaenderi (Arndt, 1913)
 Crella shimonii Pulitzer-Finali, 1993
 Crella sigmata Topsent, 1925
 Crella spinulata (Hentschel, 1911)
 Crella stylifera Hentschel, 1914
 Crella topsenti (Babiç, 1922)
 Crella triplex (Koltun, 1970)
 Crella tubifex (Hentschel, 1914)
 Crella ula (de Laubenfels, 1950)

References

External links

Poecilosclerida
Sponge genera

redpajama_set_name: RedPajamaWikipedia


The simplistic title of this film refers to one of the choices given to the Chilean public during the monumental national plebiscite in 1988. The issue at hand was the continuation of General Augusto Pinochet's military dictator regime. NO meant down with Pinochet; YES meant stay the course. Pablo Larrain's new feature tells the story of this contentious period leading up to the vote from the point of view of the dueling advertising agencies charged with convincing the public to vote YES or NO.
Of course, Larrain centres on the NO side, specifically Gael Garcia Bernal's character, Rene Saavedra, a hot-shot ad man who treats the political issue like selling soda pop. Prompted by international pressure, rules were set to ensure a fair campaign. Each side was allowed 15 minutes of airtime in each of the 27 days leading up to the election to convey information, state their case and convince the public.
Obstacles facing Rene include the angry liberal left, which wanted to vilify Pinochet as a violent tyrant who imprisoned thousands of innocent citizens during his reign; the apprehensive public, who feared even going to the polls; and the conniving opposition headed by Rene's old boss, Lucho Guzman, an equal match to Rene's commercial savvy.
Larrain throws us into the war room of activity as ideas get bounced around, and he's sure to highlight the absurd and uproarious comical options discussed. He consistently oscillates between the socio-political gravitas of the stakes and a strong farcical tone. Bernal's goofy visage makes him the ideal hero in the endeavour. Of course, he's rugged and handsome as a leading man, but also his youth and small physical stature reminds us of the David vs. Goliath challenge in which he finds himself.
No won the a special Art Cinema Prize at the Director's Fortnight Program at this year's Cannes Film Festival, due in part to Larrain's bold stylistic choice to shoot on ordinary, old-school video and with a decidedly undramatic 4:3 full frame. It's an inspired choice. The ugly graininess of video image immediately puts us in the time and place of the era and it integrates invisibly into the cleverly edited stock footage of the period. The result is an immersive political statement and the ideal artifact of this momentous period in Latin American politics.


text:
Mesembia catemacoa är en insektsart som beskrevs av Ross 1984. Mesembia catemacoa ingår i släktet Mesembia och familjen Anisembiidae. Inga underarter finns listade i Catalogue of Life.

Källor

Externa länkar

Spinnfotingar
catemacoa


text:
Man returns stolen van to Riverside mortuary after he finds dead body inside, police say
Bobby Joe Washington, 24, of Riverside is accused of stealing two mortuary vans.
(Riverside Police Department)
By Esmeralda BermudezStaff Writer
A man stole a van parked outside a mortuary in Riverside early Sunday morning, only to discover there was a body inside, police said.
Bobby Joe Washington, 24, returned the van about an hour later, then stole a different van from the same business, police said. When a mortuary worker tried to stop him, he tried to run that person over, according to police.
"I don't think I've ever heard of anything like this," said Riverside Police Department spokesman Ryan Railsback. "Out of all the bad decisions he made, he at least made one good one and brought back the deceased person."
Washington was arrested about 2 ½ miles from the mortuary on the 1900th block of Chicago Avenue. He was charged with two counts of auto theft, one count of evading police and one count of assault with a deadly weapon.
He wasn't charged with stealing the dead body because police officials said they believe he didn't mean to take it.
"We don't think he knew it was in there at the time he stole it," Railsback said.
The incident began around 1:30 a.m. The driver had just picked up a deceased person and returned to the mortuary to pick up some paperwork. He left the keys in the car and briefly went inside, officials said.
That's when the first van was stolen. About an hour later, police were notified that a second van was stolen.
Washington, who is from Riverside, led police on a 10-minute chase that ended at Linden Street and Canyon Crest Drive, police said.
"The suspect was uncooperative," Railsback said. "Until the canines got there."
esmeralda.bermudez@latimes.com
@LATBermudez
Man accused of trying to rape teenage girl out jogging in Ontario
Body found after firefighters douse blaze at Santa Ana homeless encampment
South Gate teacher gets meningitis and dies, and parents worry about health risks
Esmeralda Bermudez
Esmeralda Bermudez writes narrative stories about the lives of Latinos for the Los Angeles Times.


Radiation therapy, also called radiotherapy or irradiation, can be used to treat leukemia, lymphoma, myeloma and myelodysplastic syndromes. The type of radiation used for radiotherapy (ionizing radiation) is the same that's used for diagnostic x-rays. Radiotherapy, however, is given in higher doses.
Radiotherapy works by damaging the genetic material (DNA) within cells, which prevents them from growing and reproducing. Although the radiotherapy is directed at cancer cells, it can also damage nearby healthy cells. However, current methods of radiotherapy have been improved upon, minimizing "scatter" to nearby tissues. Therefore its benefit (destroying the cancer cells) outweighs its risk (harming healthy cells).
When radiotherapy is used for blood cancer treatment, it's usually part of a treatment plan that includes drug therapy. Radiotherapy can also be used to relieve pain or discomfort caused by an enlarged liver, lymph node(s) or spleen.
Radiotherapy, either alone or with chemotherapy, is sometimes given as conditioning treatment to prepare a patient for a blood or marrow stem cell transplant. The most common types used to treat blood cancer are external beam radiation (see below) and radioimmunotherapy.
External beam radiation is the type of radiotherapy used most often for people with blood cancers. A focused radiation beam is delivered outside the body by a machine called a linear accelerator, or linac for short. The linear accelerator moves around the body to deliver radiation from various angles. Linear accelerators make it possible to decrease or avoid skin reactions and deliver targeted radiation to lessen "scatter" of radiation to nearby tissues.
The dose (total amount) of radiation used during treatment depends on various factors regarding the patient, disease and reason for treatment, and is established by a radiation oncologist. You may receive radiotherapy during a series of visits, spread over several weeks (from two to 10 weeks, on average). This approach, called dose fractionation, lessens side effects. External beam radiation does not make you radioactive.
Autologous bone marrow transplant: The term auto means self. Stem cells are removed from you before you receive high-dose chemotherapy or radiation treatment. The stem cells are stored in a freezer (cryopreservation). After high-dose chemotherapy or radiation treatments, your stems cells are put back in your body to make (regenerate) normal blood cells. This is called a rescue transplant.
Allogeneic bone marrow transplant: The term allo means other. Stem cells are removed from another person, called a donor. Most times, the donor's genes must at least partly match your genes. Special blood tests are done to see if a donor is a good match for you. A brother or sister is most likely to be a good match. Sometimes parents, children, and other relatives are good matches. Donors who are not related to you may be found through national bone marrow registries.
Umbilical cord blood transplant: This is a type of allogeneic transplant. Stem cells are removed from a newborn baby's umbilical cord right after birth. The stem cells are frozen and stored until they are needed for a transplant. Umbilical cord blood cells are very immature so there is less of a need for matching. But blood counts take much longer to recover.
Ablative (myeloablative) treatment: High-dose chemotherapy, radiation, or both are given to kill any cancer cells. This also kills all healthy bone marrow that remains, and allows new stem cells to grow in the bone marrow.
Reduced intensity treatment, also called a mini transplant: Patients receive lower doses of chemotherapy and radiation before a transplant. This allows older patients, and those with other health problems to have a transplant.
A stem cell transplant is usually done after chemotherapy and radiation is complete. The stem cells are delivered into your bloodstream usually through a tube called a central venous catheter. The process is similar to getting a blood transfusion. The stem cells travel through the blood into the bone marrow. Most times, no surgery is needed.
Bone marrow harvest. This minor surgery is done under general anesthesia. This means the donor will be asleep and pain-free during the procedure. The bone marrow is removed from the back of both hip bones. The amount of marrow removed depends on the weight of the person who is receiving it.
Leukapheresis. First, the donor is given 5 days of shots to help stem cells move from the bone marrow into the blood. During leukapheresis, blood is removed from the donor through an IV line in a vein. The part of white blood cells that contains stem cells is then separated in a machine and removed to be later given to the recipient. The red blood cells are returned to the donor.
A bone marrow transplant replaces bone marrow that either is not working properly or has been destroyed (ablated) by chemotherapy or radiation. Doctors believe that for many cancers, the donor's white blood cells can attach to any remaining cancer cells, similar to when white cells attach to bacteria or viruses when fighting an infection.
O.W Press, F Appelbaum, P.J Martin, et al.
25 patients with relapsed B-cell lymphomas were evaluated with trace-labelled doses (2·5 mg/kg, 185-370 MBq [5-10 mCi]) of 131I-labelled anti-CD20 (B1) antibody in a phase II trial. 22 patients achieved 131I-B1 biodistributions delivering higher doses of radiation to tumor sites than to normal organs and 21 of these were treated with therapeutic infusions of 131I-B1 (12·765-29·045 GBq) followed by autologous hemopoietic stem cell reinfusion. 18 of the 21 treated patients had objective responses, including 16 complete remissions. One patient died of progressive lymphoma and one died of sepsis. Analysis of our phase I and II trials with 131I-labelled B1 reveal a progression-free survival of 62% and an overall survival of 93% with a median follow-up of 2 years. 131I-anti-CD20 (B1) antibody therapy produces complete responses of long duration in most patients with relapsed B-cell lymphomas when given at maximally tolerated doses with autologous stem cell rescue.
An autologous transplant (or rescue) is a type of transplant that uses the person's own stem cells. These cells are collected in advance and returned at a later stage. They are used to replace stem cells that have been damaged by high doses of chemotherapy, used to treat the person's underlying disease.
In most cases, stem cells are collected directly from the bloodstream. While stem cells normally live in your marrow, a combination of chemotherapy and a growth factor (a drug that stimulates stem cells) called Granulocyte Colony Stimulating Factor (G-CSF) is used to expand the number of stem cells in the marrow and cause them to spill out into the circulating blood. From here they can be collected from a vein by passing the blood through a special machine called a cell separator, in a process similar to dialysis.
Most of the side effects of an autologous transplant are caused by the conditioning therapy used. Although they can be very unpleasant at times it is important to remember that most of them are temporary and reversible.
Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. It may be autologous (the patient's own stem cells are used) or allogeneic (the stem cells come from a donor).
Hematopoietic stem cell transplantation (HSCT) involves the intravenous (IV) infusion of autologous or allogeneic stem cells to reestablish hematopoietic function in patients whose bone marrow or immune system is damaged or defective.
The image below illustrates an algorithm for typically preferred hematopoietic stem cell transplantation cell source for treatment of malignancy.
An algorithm for typically preferred hematopoietic stem cell transplantation cell source for treatment of malignancy: If a matched sibling donor is not available, then a MUD is selected; if a MUD is not available, then choices include a mismatched unrelated donor, umbilical cord donor(s), and a haploidentical donor.
The risk of catching a virus from a blood transfusion is very low.
HIV. Your risk of getting HIV from a blood transfusion is lower than your risk of getting killed by lightning. Only about 1 in 2 million donations might carry HIV and transmit HIV if given to a patient.
Hepatitis B and C. The risk of having a donation that carries hepatitis B is about 1 in 205,000. The risk for hepatitis C is 1 in 2 million. If you receive blood during a transfusion that contains hepatitis, you'll likely develop the virus.
Variant Creutzfeldt-Jakob disease (vCJD). This disease is the human version of Mad Cow Disease. It's a very rare, yet fatal brain disorder. There is a possible risk of getting vCJD from a blood transfusion, although the risk is very low. Because of this, people who may have been exposed to vCJD aren't eligible blood donors.
Graft-versus-host disease (GVHD) is a condition in which white blood cells in the new blood attack your tissues.
Erythropoietin, (/ɨˌrɪθrɵˈpɔɪ.ɨtɨn/, UK /ɛˌrɪθroʊ.poʊˈiːtɪn/) also known as EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine (protein signaling molecule) for erythrocyte (red blood cell) precursors in the bone marrow. Human EPO has a molecular weight of 34 kDa.
Also called hematopoietin or hemopoietin, it is produced by interstitial fibroblasts in the kidney in close association with peritubular capillary and proximal convoluted tubule. It is also produced in perisinusoidal cells in the liver. While liver production predominates in the fetal and perinatal period, renal production is predominant during adulthood. In addition to erythropoiesis, erythropoietin also has other known biological functions. For example, it plays an important role in the brain's response to neuronal injury. EPO is also involved in the wound healing process.
Exogenous erythropoietin is produced by recombinant DNA technology in cell culture. Several different pharmaceutical agents are available with a variety ofglycosylation patterns, and are collectively called erythropoiesis-stimulating agents (ESA). The specific details for labelled use vary between the package inserts, but ESAs have been used in the treatment of anemia in chronic kidney disease, anemia in myelodysplasia, and in anemia from cancer chemotherapy. Boxed warnings include a risk of death, myocardial infarction, stroke, venous thromboembolism, and tumor recurrence.
Granulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.
Pegylated G-CSF stays in the body for longer so you have treatment less often than with the other types of G-CSF.
Plasmapheresis is a term used to refer to a broad range of procedures in which extracorporeal separation of blood components results in a filtered plasma product.[1, 2] The filtering of plasma from whole blood can be accomplished via centrifugation or semipermeable membranes. Centrifugation takes advantage of the different specific gravities inherent to various blood products such as red cells, white cells, platelets, and plasma. Membrane plasma separation uses differences in particle size to filter plasma from the cellular components of blood.
Traditionally, in the United States, most plasmapheresis takes place using automated centrifuge-based technology. In certain instances, in particular in patients already undergoing hemodialysis, plasmapheresis can be carried out using semipermeable membranes to filter plasma.
In therapeutic plasma exchange, using an automated centrifuge, filtered plasma is discarded and red blood cells along with replacement colloid such as donor plasma or albumin is returned to the patient. In membrane plasma filtration, secondary membrane plasma fractionation can selectively remove undesired macromolecules, which then allows for return of the processed plasma to the patient instead of donor plasma or albumin. Examples of secondary membrane plasma fractionation include cascade filtration, thermofiltration, cryofiltration, and low-density lipoprotein pheresis.
The Apheresis Applications Committee of the American Society for Apheresis periodically evaluates potential indications for apheresis and categorizes them from I to IV based on the available medical literature. The following are some of the indications, and their categorization, from the society's 2010 guidelines.
Scott Murphy, Samuel Litwin, Leonard M. Herring, Penelope Koch, et al.
In an attempt to determine the indications for platelet transfusion in thrombocytopenic patients, we randomized 56 children with acute leukemia to one of two regimens of platelet transfusion. The prophylactic group received platelets when the platelet count fell below 20,000 per mm3 irrespective of clinical events. The therapeutic group was transfused only when significant bleeding occurred and not for thrombocytopenia alone. The time to first bleeding episode was significantly longer and the number of bleeding episodes were significantly reduced in the prophylactic group. The survival curves of the two groups could not be distinguished from each other. Prior to the last month of life, the total number of days on which bleeding was present was significantly reduced by prophylactic therapy. However, in the terminal phase (last month of life), the duration of bleeding episodes was significantly longer in the prophylactic group. This may have been due to a higher incidence of immunologic refractoriness to platelet transfusion. Because of this terminal bleeding, comparison of the two groups for total number of days on which bleeding was present did not show a significant difference over the entire study period.
INTRODUCTION — Hemostasis depends on an adequate number of functional platelets, together with an intact coagulation (clotting factor) system. This topic covers the logistics of platelet use and the indications for platelet transfusion in adults. The approach to the bleeding patient, refractoriness to platelet transfusion, and platelet transfusion in neonates are discussed elsewhere.
Pooled Platelets – A single unit of platelets can be isolated from every unit of donated blood, by centrifuging the blood within the closed collection system to separate the platelets from the red blood cells (RBC). The number of platelets per unit varies according to the platelet count of the donor; a yield of 7 x 1010 platelets is typical . Since this number is inadequate to raise the platelet count in an adult recipient, four to six units are pooled to allow transfusion of 3 to 4 x 1011 platelets per transfusion . These are called whole blood-derived or random donor pooled platelets.
Advantages of pooled platelets include lower cost and ease of collection and processing (a separate donation procedure and pheresis equipment are not required). The major disadvantage is recipient exposure to multiple donors in a single transfusion and logistic issues related to bacterial testing.
Apheresis (single donor) Platelets – Platelets can also be collected from volunteer donors in the blood bank, in a one- to two-hour pheresis procedure. Platelets and some white blood cells are removed, and red blood cells and plasma are returned to the donor. A typical apheresis platelet unit provides the equivalent of six or more units of platelets from whole blood (ie, 3 to 6 x 1011 platelets) . In larger donors with high platelet counts, up to three units can be collected in one session. These are called apheresis or single donor platelets.
Advantages of single donor platelets are exposure of the recipient to a single donor rather than multiple donors, and the ability to match donor and recipient characteristics such as HLA type, cytomegalovirus (CMV) status, and blood type for certain recipients.
Both pooled and apheresis platelets contain some white blood cells (WBC) that were collected along with the platelets. These WBC can cause febrile non-hemolytic transfusion reactions (FNHTR), alloimmunization, and transfusion-associated graft-versus-host disease (ta-GVHD) in some patients.


Should kids summer break be LONGER?
Should kids' summer break be LONGER? According to a new survey, the most popular answer with parents is YES . . . 41% think summer break should be at least three months. On the other side of things, 13% think we should ABOLISH summer break completely.


text:
using System.Diagnostics;

namespace System.Reflection.Metadata
{
    public struct StandaloneSignature
    {
        private readonly MetadataReader _reader;

        // Workaround: JIT doesn't generate good code for nested structures, so use RowId.
        private readonly uint _rowId;

        internal StandaloneSignature(MetadataReader reader, StandaloneSignatureHandle handle)
        {
            Debug.Assert(reader != null);
            Debug.Assert(!handle.IsNil);

            _reader = reader;
            _rowId = handle.RowId;
        }

        private StandaloneSignatureHandle Handle
        {
            get { return StandaloneSignatureHandle.FromRowId(_rowId); }
        }

        public BlobHandle Signature
        {
            get { return _reader.StandAloneSigTable.GetSignature(_rowId); }
        }

        public CustomAttributeHandleCollection GetCustomAttributes()
        {
            return new CustomAttributeHandleCollection(_reader, Handle);
        }
    }
}

redpajama_set_name: RedPajamaGithub


As we dive in to the heart of Autumn, we celebrate Heritage Day. An African tradition in my culture that celebrates all the different cultures on the African continent and diaspora. I choose to take a book from tradition, and get some much needed benefits from Bentonite Clay.
This is the Aztec Secrets Indian Healing Clay which is one of the most popular Bentonite Clay's on the market. This clay is titled the "Most Powerful Clay in the World" by many in the beauty community. And there is a reason for it. This mask draws toxins and metals from the skin and body to detox the deep layers of the skin. It cleans out pores, and gets rid of acne and congestion.
Mix with Apple Cider Vinegar or Witch Hazel for best results including toning, and oil balancing of the skin. Mix in a plastic or wooden bowl with a spoon alike (as metal and other minerals can nullify the clay) until you get a thick, creamy clay. Spread on your face and leave on for 30 minutes or until dry.
Tip. steam your face with a Facial Steamer first to soften skin for better results!
Your skin might be a bit red afterwards, but it will fade. The redness is caused by the detoxing power of the clay. Don't forget to moisturize well.


Gift Certificates are available for purchase here at Pur Zen Massage Therapy.
-If the Gift Certificate(s) are to be sent somewhere other than the shipping address please provide the address and with whom the envelope needs to be addressed to.
Gift Certificates can be purchased by the session length(60-min/$80, 90-min/$100, and 2-hours/$130).
Gift certificate sales are final. NO REFUNDS. GC must be used by expiration date. You may pay 1/2 of the Gift Certificate value to extend the GC one month from expiration date. This must be paid before the session.


We asked all of our contributors to tell us about their favourite lines of Milton and their experiences of reading his work.
I am very interested in the Universe - I am specializing in the Universe and all that surrounds it. I am studying Nesbitt's book - The Universe and All That Surrounds It, an Introduction. He tackles the subject boldly, goes through from the beginning of time right through to the present day, which according to Nesbitt is October 31, 1940. And he says the earth is spinning into the sun and we will all be burnt to death. But he ends the book on a note of hope. He says 'I hope this will not happen.' But there's not a lot of interest in this down the mine.
Paradise Lost ends on a note of hope. Having spent hundreds of pages telling us how the world got messed up, Milton wheels in the archangel Michael to reassure Adam (and us) that there's a happy ending to the story, before kicking him out of the garden. He does this by speed-reading the rest of the Bible to Adam (in blank verse, of course). Readers don't always find this narrative section very excitingly written. Perhaps it's something about trying to cram the whole history of the cosmos into a few pages that makes it seem a bit clunky at times.
These few lines, though, I find oddly touching. Michael is reassuring Adam that, by trusting in God, he can gain a wisdom which is greater and more valuable than an encyclopaedic knowledge of the cosmic order. Adam and Eve have just messed up the cosmos for themselves and their descendents, but through faith their inner world can begin to be put back together again. 'Charity' (a word sometimes understood as 'love' in the Protestant tradition) is the 'soul' which will hold their renewed selves together and enable them to face the now harsh outer world.
This stress on inwardness can seem like a withdrawal, a giving up on the world. Perhaps this reflects the disillusionment of the Puritan movement Milton was part of. They had tried to change the world in the English Civil War and it had all gone horribly wrong. They hadn't restored paradise and were sometimes closer to chaos, and, now King Charles II had returned, they were in a sticky situation. Because of this, there was a tendency for them to turn inwards, away from public affairs to their own private spiritual experiences. Many recent readers find this withdrawal unsatisfying.
But this passage doesn't have to be read that way, since it is in the context of the promise of a future restoration of the world to be brought about by 'the woman's seed' (XII.607), meaning Eve's descendant, Christ. The world will once again be made new. But not now, not yet. The 'paradise within' is not a substitute for the new paradise to come, it is a foretaste of it. But we will need to be patient. There's a long road ahead.
of these communities feed very well. Occasional diversions include blogging, taking photos and playing the tuba.


text:
Economics5 September 2021
Managing fuel concerns as the industry recovers
Fuel presents a diverse picture as airlines strive to recover from the devastating impact of the pandemic.
A sharp fall in demand for aviation fuel saw the industry bill go down from $186 billion in 2019 to just $78 billion in 2020. Supplies built up and fixed and floating storage facilities were quickly filled. This caused a price drop and May 2020 futures contracts for WTI crude actually hit a negative rate.
But this proved temporary. Prices returned to about $70 per barrel by mid-August 2021 as key domestic aviation markets started to improve.
Even so, Sustainable Aviation Fuels (SAF)—the future of the aviation fuel market—remain considerably more expensive than conventional fuel. SAF are an extremely effective tool for reducing CO2 emissions. They are a proven technology and delivered as a drop-in solution, meaning that they are blended into conventional fuel outside the airport and thus require no additional infrastructure.Nevertheless, insufficient supply and high prices mean that SAF uplift has been just a small fraction of the 0.1% of total fuel volume that airlines would consume in a normal year.
SAF need governments' support to scale up production and bring down the price. Airlines are striving to reduce emissions but also coming out of the biggest crisis ever with empty coffers.
Despite this, in Europe, the "Fit for 55" package proposes additional fuel taxes for intra-European flights that could have a massive impact on all future fuel prices and will certainly increase costs for airlines. IATA opposes fuel taxes to solve environmental concerns and instead emphasizes the need for governments to promote the rollout of SAF.
"Aviation is committed to decarbonization as a global industry," says Willie Walsh, IATA's Director General. "We don't need persuading, or punitive measures like taxes to motivate change. In fact, taxes siphon money from the industry that could support emissions' reducing investments in fleet renewal and clean technologies. To reduce emissions, we need governments to implement a constructive policy framework that, most immediately, focuses on production incentives for SAF and delivering the Single European Sky."
Fit for 55 proposes a mandate to increase SAF utilization to 2% of jet fuel use by 2025 and at least 5% by 2030. It does not, however, suggest any specific measures to reduce SAF costs.
The industry's pandemic-induced financial struggles are even affecting airlines' ability to manage conventional jet fuel. "Hedging requires a reasonably safe forecast of volumes and credit lines with the banks," says Alexander Kueper, IATA's Director, Fuel. "Both are a challenge at present for some airlines, which makes is extremely difficult for them to protect themselves against price increases through hedging."
As it stands, the outlook for the fuel market is aligned with the recovery of air travel. Although domestic traffic looks strong, international travel presents a more complicated picture. Fuel for international travel made up around 65% of total fuel used pre-COVID-19, so demand is expected to remain unpredictable for the foreseeable future.
Some refiners have even raised diesel production. It remains to be seen how many of them will switch back to jet fuel once demand returns. Any hesitation could become a challenge for the restart.
Supply issues
At least no significant supply bottlenecks are expected as the industry returns to strength. In fact, the pandemic eased a few infrastructure pain points.
Some airport fuel depots in Europe were facing capacity problems before the pandemic, but now have sufficient capacity to cover demand peaks without additional weekend deliveries, for example. Also, the European NATO (CEPS) pipeline had more demand than capacity before the pandemic, which is no longer the case.
There are some challenges though. In the United States, a shortage of truck drivers is causing supply issues at smaller airports while larger facilities worldwide are seeing sharp increases in infrastructure unit cost, such as for fuel hydrant system providers. This is being passed on to the airlines.
"We acknowledge the need of infrastructure operators to cover the cost and keep the infrastructure running, but there has been a lack of transparency in quite a few cases," says Kueper. "IATA is advocating for more transparency, which, at least for the European locations, is a legal requirement set by the EU Ground Handling Directive."
In Africa, meanwhile, the drop in fuel volumes initially eased pressure on fuel infrastructure challenges at certain locations. But volumes are improving, and concerns remain. In addition, the fuel price on the continent continues to be, on average, higher than in other regions. Some airports lack competition and others have fuel prices set artificially high by governments.
Digitalizing the refueling process
Fuel orders, delivery tickets, receipts, and the suchlike have been paper-based since inception and in some locations that remains the case. But a digitalized process saves time and money, avoids errors, and simplifies the interaction between cockpit crew and refueling staff.
"We must accelerate this journey to benefit from substantial efficiency gains and increased transparency," says Alexander Kueper, IATA's Director, Fuel.
To ease the implementation of digital solutions, the IATA Fuel Data Standards Group (FDSG) has already incorporated the use of digital signatures for compliance with diverse local regulations.
At Boston Logan Airport, i6, a startup in the JetBlue Technology Ventures portfolio, has implemented its full suite of tools to aid the refueling process for the entire fuel supply chain.
"Our technology provides a comprehensive platform for the into-plane operator so that they can better plan, allocate, and track the entire refueling process," says Steve Uhrmacher, CEO, i6 Group. "This includes the moment that the fuel order is first placed through to post-event reconciliation."
Uhrmacher believes a digital process can save several minutes in every refuel, which he describes as a "game-changer" for an industry where delayed flights can mean thousands of dollars in lost revenue. Moreover, more accurate data transmission reduces the risk of over-fueling by 50%, cutting the initial cost of fuel and aircraft weight, a notable factor in subsequent fuel use.
How the various factors affecting fuel will play out as the industry returns to normal is difficult to ascertain. Fuel has always been a significant cost for airlines. But the pandemic and subsequent recovery has blurred the picture as digitalization, new aircraft, and environmental mitigation, both mandated and voluntary, add new pressures to supply and demand.
Credit | iStock
Passenger travel still on the road to recovery
IATA announced that the air travel recovery continued through November 2022.
Amount of blocked airline funds continues to increase
IATA warned that the amount of airline funds for repatriation being blocked by governments has risen more than 25% ($394 million) in the last six months.
Passenger traffic continues recovery
IATA announced that the recovery in air travel continued in October.


The monsters in Tim Burton's films are not only some of the gentlest and deepest creatures in cinema history, but also some of the most conscientious. In fact, it can be argued that the uniqueness of Burton's monsters such as Beetlejuice (Beetlejuice, 1988), Edward (Edward Scissorhands, 1990), and the Penguin (Batman Returns, 1992), lies in their journey towards acquiring a conscience. This journey takes place in a cinematic world shaped by Burton's unique vision, and it is the mise-en-scène of this world—including all elements from staging and production design to light setup and sound—that ultimately determines the personality and psychology of its inhabitants. Through his mastery of mise-en-scène, Burton thus creates unique realms in which his monsters can play, learn, and grow.
In this course, we will view the films of Tim Burton through a critical lens, concentrating on his endowment of monsters with psychological profiles that set them apart from other on-screen creatures. To accomplish this task, we will first learn how to analyze a film scene, from the set-up of frames to the different elements that establish a mise-en-scène. Once these elementary skills are in place, we will peel away the layers of Burton's mise-en-scène to determine the visual tools he uses in creating his psychological effects. Finally, our critical discussion of Burton's films will lead us to broader questions concerning genre cinema and the aesthetics of film in general. All throughout, we will be led by a quest for the monstrous. What really makes a monster? What does it mean to be monstrous? And why is Tim Burton so concerned with showing us the monster in ourselves?


People are being urged to beware of fake products and websites in the run-up to Christmas.
Offers for mobile phones, clothes, shoes and jewellery are the most likely to be fraudulent, according to the Action Fraud group.
Along with City of London police, it is appealing to people to give more thought to where they source presents.
In 2016, it is estimated that nearly £16 million was lost to Christmas shopping fraud.
Common items reported to the agency include fake Yeezy trainers, Kylie Jenner make-up, hair dryers, drones and Fitbit watches.
Latest figures suggest that Christmas fraud increased by 25% between 2015 and 2016. Analysis of last year's crimes also suggests that 65% of crimes at Christmas were linked to online auctions.
UK's fraud hotspots revealed by Which?
The #ThoughtThatCounts campaign is encouraging gift-buyers to pause during the festive rush to consider the source of their goods.
It is releasing a series of videos aimed at illustrating that one small mistake can mean that a thoughtful gift never turns up.
Commander Dave Clark, national co-ordinator for economic crime said: "Fraudsters see the Christmas rush as an ideal opportunity to take advantage of people's generosity without a single care about the consequences this may cause for the victim.
"With a sharp rise in fraud reporting at Christmas time it is more important than ever that people do everything they can to protect themselves from fraudsters, stopping them from enjoying the holiday season at the expense of others."
Should we all impose a one-gift rule at Christmas?


The well established global icon of boxing 8-weight class World Champion, Manny Pacquiao (59-6-2 38 KO's), will travel to Brisbane Australia to fight virtually unknown Jeff Horn (16-0-1 11 KO's) in a bout for Pacquiao's WBO Welterweight Title. When this fight was originally signed it came under major scrutiny as many fighters were in line for a title-shot with a lucrative payday for a fight against Pacquiao. Jeff Horn is 100% undeserving of this fight. With such an unknown opponent such as Horn, US fight fans will be able to see Pacquiao for the first time on regular cable (ESPN) in nearly a decade. This is such a mismatch that jokingly this fight has been compared to the original movie Rocky when champion Apollo Creed gave a no-name club fighter Rocky Balboa a shot in Philadelphia over the 4th of July weekend. If Pacquiao wants any discussion at a rematch with Mayweather he must demolish Horn with a vicious early knockout. He must be the Manny of old that the fans want; throw hands with no conscience leading to one of the greatest knockout streaks in welterweight history. The last Manny we need to see is one of a tamed political temperament showing too much emotion towards his opponent. If so, this could be the final fight of Pacquiao's legendary career.
Fighter Breakdown: Jeff "The Hornet" Horn brings limited experience to the ring, especially that of world championship caliber of Pacquiao. Horn does hold an element of surprise to his fighting ability. He was a dedicated amateur with a quality chin and good stamina. Horn is an orthodox style fighter. Experience is going to be a huge factor for Horn as he is stepping into the ring with one of the greatest southpaw welterweights of all-time and Horn has not faced a quality southpaw at any point in his career. That lack of experience against southpaws might get him knocked out.
Manny Pacquiao is on the backside of his prime, but still has all the tangibles and skills to handle Horn with ease. Look for Pacquiao to work ferociously off the counter as Horn will more than likely be overly aggressive fighting in-front of his fellow countrymen. Sitting in the southpaw stance will make it easy for Manny to counter off heavy over-the-top right hands that Horn will throw early prior to establishing a distance using proper feints if he doesn't want to be KO'd.
Fight Prediction: This will be no movie; Manny Pacquiao will put on a boxing clinic against Jeff Horn. The only question is if his KO power of the past will reappear against an inferior opponent.
Previous: NBA Free Agency Frenzy- The Best Fit Will Be…..


GrassRoutes electric bike adventures provided cycle hire to Rock agus Roam corporate group in Glenveagh National Park on the 5th of April.
GrassRoutes welcome and cater for corporate groups, and Glenveagh National Park is the perfect place to visit for a corporate outing. The park is set on 16,000 hectares in the heart of the Derryveagh mountains.
Glenveagh Park is ideally suited for group activities, with its wonderful trails, walks and gardens. Travelling into Glenveagh Park is truly an amazing experience, the location is one of the most remotest in Co. Donegal, the wilderness is majestical and haunting, in spring the surrounding rolling hills are a beautiful array of amber, yellow and burnt oranges.
The roads are quite and visitors can cycle up towards the stately 19th century Castle on the grounds, which even features it's own swimming pool beside the enigmatic and natural lake. There is also a visitors centre and not to forget the highly recommended tearooms and restaurant, serving delicious home cooked treats to regain your energy after your cycle around the park.
The Gardens in Glenveagh reflect the dedication the team have to preserving the wonderful heritage this place has to offer and will be enjoyed by botanical enthusiasts and non-enthusiasts alike.
Rock agus Roam provide culture based experiences and outdoor activities for those seeking adventure in Donegal.
GrassRoutes thoroughly enjoyed meeting the group on Saturday and hope to see them all again…..


text:
Starting an Office Supply Company in Singapore
Home>Guide / FAQ>Starting an Office Supply Company in Singapore
5 mins | September 8th, 2021 | 104+ Discussions
The office supply business in Singapore is one which has been rapidly growing. Therefore, the registration and incorporation of a Singapore office supply company has become a more common occurrence than ever before. Owners of these companies often work with copy centers as well as other related companies.
Definition of an Office Supply Company
Why One Should Start an Office Supply Company in Singapore
How to Start an Office Supply Company in Singapore
Licenses and Permits for Starting an Office Supply Company in Singapore
An office supply company is a company which provides all the supplies to be regularly used in offices by businesses and other organizations. Office supply companies do much to serve offices and facilitate their activities. Important office supplies include expendable items which are used on a daily basis such as paper clips, sticky notes, staples and staplers, and hole punches among others. Most office supply companies are not restricted to such items. In most cases, they also deal in larger and bulkier equipment which are necessary in offices. Such equipment includes computers, printers, photocopiers, fax machines, and cash registers among others. The largest and most comprehensive office supply companies do not stop at such equipment because they also provide offices with necessary office furniture. Among the office furniture provided by such companies include cubicles, chairs, filing cabinets, and armoire desks.
The office supply industry is one which has recently been experiencing much growth and an influx of many new businesses. Many office supply companies have also expanded to work with copy centers. By doing so, they are able to facilitate the creation and printing of important printed business material such as business cards. They are also able to offer customers high-quality printing and binding. Some other office supply companies, meanwhile, opt to work with businesses which provide services for offices such as shipping, packaging, bulk mailing, and other similar services which are of benefit to offices.
Starting an office supply company in Singapore provides numerous advantages to the business owner. Among the advantages which the office supply business provides is that of business flexibility. The business owner will have flexibility in business operations as well as the business's customers. The owner of the company will not be tied to a single business partner because the owner will be able to provide the office supplies to any number of office equipment users within Singapore. This flexibility with regard to customers will do much to increase the likelihood of the success of the business.
Office supply companies based in Singapore also have much ability to gain traction with current and potential customers. This is because the office supply business of Singapore is one which has been growing at a rapid rate. Due to the increase in the number of developed offices in Singapore, office supply companies in several parts of the country have been able to expand their customer base and make the office supply business a more financially viable option. Furthermore, the expected establishment of more offices across Singapore in the future will lead to a need for more equipment as well as the replacement of older equipment. This would therefore mean that the office supply business will continue to experience a period of economic growth in the near future.
On a related note, perhaps you have become interested in starting an office supply or any other company in Singapore. We at Paul Hype Page & Co can be of service to you if you have. We will work with you in order for you to fully understand and complete the process of company incorporation in Singapore. Once you have finished using our services, your new Singapore company will have been incorporated according to the company laws of the country.
The solutions we offer for companies and their owners cover important areas such as incorporation, taxation, auditing, and work visas, among others.
We are always ready and willing to work with any genuine and legitimate company which requires our incorporation services or any other services we provide.
We offer Singapore company incorporation, consultancy services, auditing, taxation, immigration work visas & annual compliance services.
Every country has its own challenges which require new business owners to carefully navigate the unpredictable and sometimes difficult to understand business environment. Similarly, the business environment of Singapore presents challenges to prospective office supply company owners. However, by following certain steps, such an owner will be likely to experience much business success through the ownership and operation of an office supply company in Singapore.
The first step to be taken when starting an office supply company in Singapore is that of preparation to own the business. Having a viable business plan ought to be the first step to ensure the success of the business. Once a suitable business plan has been created, several other steps are to be taken.
The next step is that of registration or incorporation of the Singapore office supply company. Some who are unsure about the details of Singapore company incorporation might choose to work professional on the guidance of company registration in Singapore. Starting an office supply company in Singapore requires the usual process of company registration with the Accounting and Corporate Regulatory Authority (ACRA) to be completed before the business owner is permitted to operate the business in the country. All of the necessary details about the company are to be made available to ACRA in order for the company to be officially incorporated. Some of the company's details that you will be expected to provide include the company name which must have been reserved and approved by ACRA as well as personal information about the company's directors and shareholders.
At this point, the next course of action to be taken is that of opening a corporate bank account. This bank account will do much for the financial welfare of the company. The company owner may also choose to work with people who are experienced in matters related to taxation in Singapore in order to benefit from any tax advantages which may be claimed by the company as well as reduce the total tax burden of the company in a manner which is in accordance with the existing tax laws of Singapore.
Once everything is ready and the company has been completely registered, it will have every right to operate in Singapore. During the initial phase of business operations, the new Singapore-based office supply company ought to select suitable people to serve as key stakeholders in order to help the business grow and thrive. The company will have to hire employees to help in the supply and management including its daily operations.
Starting an office supplies company in Singapore will require appropriate compliance with licensing standards and procedures of the country. Some of the licenses and permits required related may include those related to retail, imports, exports, health and safety, and land or property rights. It is always advisable to remain duly updated about business licensing requirements in Singapore so that the business can be run in the most suitable manner possible.
It might not always be easy to obtain any required business licenses or permits in Singapore. Some might not have fulfilled government requirements even if they believe they have done so. However, we at Paul Hype Page & Co can ensure that such will never be the case for you. We will provide you with assistance regarding all of the existing licensing requirements of Singapore. Should you require us to do so, we will also contact any authorities for further information with which we can provide you regarding Singapore business licenses.
Starting an Office Supply Company in Singapore FAQs
What are the leading office supply companies in Singapore today?Tiwi2020-06-22T12:29:22+08:00
What are the leading office supply companies in Singapore today?
There are a number of office supplies companies in Singapore which have emerged as the country's leaders within the industry. Some of Singapore's leading office supply companies today include Stationery World, Lyreco, Evergreen Stationery, Home n Office, LTC Office Supplies Pte Ltd, and Boon Lay Stationery.
Is it possible for office supply companies in Singapore to refuse to work with copy centers or other Businesses?Tiwi2020-06-22T12:28:34+08:00
Is it possible for office supply companies in Singapore to refuse to work with copy centers or other Businesses?
Although many office supply companies in Singapore work with copy centers or other related businesses, such is not a requirement. Companies which refuse to do so might have valid reasons for this refusal. Among these reasons may include cost, division of profits, and amount of control possessed over the business.
admin2021-09-08T16:49:20+08:00March 18, 2020|


Looking for name-brand clothing or home furnishing? Or something for the family pet? NewMarket Square has it all. Plan your next visit with our directory.
Whether it's time for a quick lunch or you're eager to unwind after the work week, NewMarket Square has the restaurants to whet your appetite.
Free, family-friendly events make NewMarket Square the place where the community comes together. Make plans to join us for our next big celebration.
One of Kansas' largest outdoor marketplaces also serves as one of Wichita's premier meeting spaces. The latest clothing, popular dining and leading superstores make NewMarket Square a Wichita destination. This northwest Wichita landmark serves as a town center that integrates retail and dining with family fun. Outdoor spaces and open-air shopping make our center a community focal point. Discover what's new and check out the variety of stores in our neighborhood. Whether you're shopping for groceries or the latest electronics, you'll find an atmosphere that invites, and a spot where friends come together.
Groceries? A new swimsuit? NewMarket Square has everything you need – from house-warming gifts to the next mattress for your home.
American, Asian, Italian, Mediterranean, Southwestern – casual or upscale – it's all on the menu at NewMarket Square.
No-appointment haircuts or luxurious spas – NewMarket Square has the services to make you look and feel your best.


I liked it. That said...much ado about nothing.
Why did his mother, after choosing not to abort him, then name him "Time"?
They just said "Time runs out on the first half." Did Tebow do that?
wouldn't have surprised me in the least if it had been something like that.
My local AM talk station in Los Angeles got a copy late last week and played it one time. They played interviews about it before playing the ad spot. Even then, it seemed "much ado about nothing", as ThreadKiller mentioned earlier.
But as the host mentioned on the radio show, after playing the spot, it opens the door for more political spots (in the Super Bowl) in the future.
Yes, but apparently only their side of politics.
Actually, Faith, the radio show specifically mentioned that this ad opened the door for Planned Parenthood, and others of that ilk, placing ads in the future. And not just about abortion, but other issues as well.
Yeah, you're right. Although Planned Parenthood didn't have the money to run an ad during the Superbowl.
This is the second time I can think of that CBS (not sure if it was the Superbowl) refused ads of a more liberal bent.
Nothing offensive from what I saw. It was certainly better than the POS moveon.org sneaked into the 2004 Super bowl via the Local TV Slots. (They did this after CBS Refused to carry their Ad.) Many Advertisers, knowing their Ads contain offensive material will do this because the Local Stations don't have the money to take on any Legal Challenges the advertiser may toss their way if they refuse to carry the Ad. This is why you see things like "ED Pill' Ads aired during Childrens Shows!
wow the left needs to pick their battles a lot better... (speaking from the left) this was a rather uneventful if not thoughtful ad.
"waaah they shared their beliefs and wanted to share it in order to convey the message that theirs is right and others are wrong! "
Feminists are "NOW" pissed-off over the violence in this commercial. They say that Tim tackling his mother promotes violence against women.
"I am blown away at the celebration of the violence against women in it. That's what comes across to me even more strongly than the anti-abortion message. I myself am a survivor of domestic violence, and I don't find it charming. I think CBS should be ashamed of itself."
No statement issued about the violence against Betty White in her commercial.
Well, it's not nice to tackle your mother... or old ladies.
I don't really care, but I HATE Focus on the Family so much!
I thought it was kind of sweet and harmless.
I kept waiting for the rebuttal commercial featuring some grief stricken father who would tell the tale of convincing his wife to go through with her pregnancy when they had the same diagnosis only to watch his baby anguish in pain until it finally died in her arms and then she went crazy and took an overdose of pills a month later.
It's not the violence they're really complaining about. You KNOW they wanted to complain about the whole abortion issue, stating that it's a woman's right to choose, blah blah blah. Well, Mrs. Tebow chose to have her baby instead of kill it...doesn't that constitute as a woman's right to choose?
When I went to bible college back in 91 we were often met with the standard anti abortion dialogue one would expect at a conservative Christian college.
One morning at chapel this highly respected and nearly revered minister was guest speaker and was talking about hot button issues and the church. He then said, "God, is pro choice"
The sound of an administration and 500+ kids choking back bile and discomfort was telling.
He then went on further to talk of free will and Christ taking ownership of the keys to life and death from the devil during the "three days" and so on.
Needless to say the campus was divided that day and that moment was talked about and referenced for the rest of the year.
One of the greatest moments of my time there.
I witnessed a man of God who thinks.
Well, supposedly the Bible refers to the unborn as humans and "children". And combined with "Thou shalt not kill", I can't see how a minister or priest or rabbi could put forth the pro-choice sentiment. Otherwise, from what I understand, the Bible doesn't say anything about abortion per sé. The only pro-choice argument I've ever heard from the standpoint of the Bible is that God gives us free will. But that argument doesn't mean he approves. We have the free will to do all sorts of things---it doesn't mean it's all OK.
So, from a religious or Biblical standpoint, I don't see how abortion could be considered OK.
That's why they didn't bother with the fact that Betty White was tackled, too. Had White stated she was anti-abortion, they'd probably have complained about her commercial, too.
Well, supposedly the Bible refers to the unborn as humans and "children". And combined with "Thou shalt not kill", I can't see how a minister or priest or rabbi could put forth the pro-choice sentiment.
And yet the church supports pro-war candidates. I thought war killed humans and children as well?
You might wanna do some research on the translation and meaning of "Thou shalt not kill" (has to do with killing versus murder). In addition, the Bible found just grounds for numerous wars. It never said that war was never justified.