text:
VSU Presents Juried Student Art Competition, Exhibition Online
Ramiro Santillan of Valdosta, Georgia
Projected Color (Oil on Canvas)
Shelby Coulter of Jackson, Georgia
Impeach (Cyanotype)
Hannah Gandy of Valdosta, Georgia
Flagler Beach (Intaglio)
Maria Carbonell of Barranquilla, Colombia
Tumbao (Digital Art)
Fourth Place
VALDOSTA — Valdosta State University presents its 22ndannual Juried Student Art Competition and Exhibition on The Bonfire (blog.valdosta.edu). The Dedo Maranville Fine Arts Gallery, which traditionally hosts this show, may be temporarily closed due to the ongoing global health crisis, but faculty and staff in the Department of Art and Design are excited to share the creative accomplishments of these students through The Official Blog of Blazer Nation.
A campus-wide invitation to participate in the 2020 Juried Student Art Competition and Exhibition was issued earlier this year to all currently enrolled VSU students. Regardless of their major area of study, students were encouraged to share their artistic talents by submitting a maximum of four two-dimensional and/or three-dimensional works, including graphic design, illustration (digital and traditional), interior design (presentation boards, illustrations, models, and so on), computer animation, drawing, printmaking (lithography, etching, silkscreen, relief, collographs, etc.), painting, aqueous media, jewelry, photography (digital and darkroom), ceramics, small metals, sculpture, and mixed media.
Julie Bowland, Dedo Maranville Fine Arts Gallery director and professor of art, said that 59 students submitted 145 different works of art for the event.
Dr. J. Stephen Lahr, the 2020 Juried Student Art Competition and Exhibition juror, reviewed the submissions and selected 50 individual works from 35 students to be featured and to compete for various prizes — first place, second place, third place, fourth place, and honorable mention honors.
Ramiro Santillan of Valdosta, Georgia, earned first place honors.
Shelby Coulter of Jackson, Georgia, earned second place honors.
Hannah Gandy of Valdosta, Georgia, earned third place honors.
Maria Carbonell of Barranquilla, Colombia, earned fourth place honors.
Honorable Mention honors went to Ali Holcomb of Valdosta Georgia; Alyse Keith of Chickamauga, Georgia; Amaka Ebubedike of Alpharetta, Georgia; Baylie Maddalone of Jonesboro, Georgia; Camille Sowell of Thomasville, Georgia; Emely Montes de Oca of Hialeah, Florida; Hannah Gandy of Valdosta, Georgia; Lisa Taylor of Valdosta, Georgia; Mackenzie Percy of Charleston, South Carolina; Nariel Tribble of Savannah, Georgia; Rachel Mathis of Nashville, Georgia; and Taylor Gray of Valdosta, Georgia.
"The participating student artists exhibit a wonderful range of diverse media, styles, and artistic outlooks in this annual showcase of emerging talent," Bowland said. "Interior design, graphic illustration, photography, drawing, painting, ceramics, sculpture, and mixed media are all included in this exciting multi-media exhibition. This is one of the most eagerly awaited exhibitions, as any and all VSU students are eligible to compete and show their art."
Lahr, an educator with more than 50 years of teaching experience, including 28 years at VSU, said that he judged the works based on artistic skill in a medium, the creative expression of the artist, the content of the work, and the ability to draw the viewer into the meaning of the piece. He is an active member of the regional arts community and currently serves as a member of the Board of Directors and chairman of the Education Committee for the Lowndes/Valdosta Arts Commission. He is a noted watercolor, acrylic, and mixed media painter.
"Each artist who had a piece adjudicated into the exhibit was worthy of inclusion and should feel honored," he shared.
Lahr said that he was "impressed with the skills and expressions of each artist." To the students who were selected for an award, he said, "Your work, in my judgment, was outstanding."
http://www.valdosta.edu/colleges/arts/art/


English Premier League fixtures schedule 2016/2017 – EPL Weekly Fixtures – Find out the upcoming fixtures in the Premier League every weekend on DailiesRoom Sport, also View English Premier League fixtures, along with other competitions involving Premier League clubs, on the official website of the Premier League. So what are we still waiting for come Find out Premier League 2016/2017 fixtures, current matches and all of the current season's Premier League 2016/2017 schedule.
Mourinho and Guardiola have faced each other a total of 16 times. The Man City manager comes out on top, winning seven of those clashes, compared to Mourinho's three.
Following the absences of Man City world-class striker Aguero and are playing away from home, Jose Mourinho and his men are favorite to win the match Derby do to Manager long staying experience on PL.
It will make players to play as the wish because better and high salaries always motivated a player to hv more self confidence, i mite be so happy if Liverpool players they are going to be paid well. Or if Liverpool manager has already done to all Liverpool player thats will sound good.


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text:
Дмитрий Евгеньевич Страшнов (род. 31 мая 1967 года, Москва, РСФСР, СССР) — российский предприниматель и управленец. Работал Генеральным директором ФГУП «Почта России» (19 апреля 2013 — 30 июня 2017 года). С ноября 2017 года — операционный директор группы «Еврохим», с 1 июля  2018 года — главный исполнительный директор.

Ранние годы
Родился 31 мая 1967 года в Москве.

В 1991 году с отличием окончил Московский государственный технический университет им. Н. Э. Баумана. В 1999 году получил степень MBA в бизнес-школе INSEAD (Франция).

В 1991—1992 годах работал менеджером в совместном российско-германском предприятии «Аквариус Системс Интеграл», занимающимся изготовлением компьютеров.

В 1992—1994 годах руководил собственным бизнесом в сфере графического дизайна, возглавляя собственную компанию «Дистрайд».

Работа в Electrolux
В 1994 году был назначен руководителем российского подразделения Electrolux Home Appliances. Отвечал за продвижение и развитие брендов Electrolux, Zanussi, AEG, которые впоследствии стали одними из самых популярных у россиян.

Работа в Phillips Royal Electronics
В 2000 году назначен генеральным директором Philips Consumer Electronics в России. Страшнов пришел на фоне кризиса 1998 года, когда компании пришлось списать все инвестиции, вложенные в строительство крупнейшего телевизионного завода в Воронеже, закрыв проект. За период управления компанией доля Phillips на российском рынке бытовой электроники увеличилась с 4 до 15%. Была запущена сборка телевизоров в СЭЗ (свободная экономическая зона) Калининградской области c целью оптимизации таможенных расходов и снижения логистических затрат. 70% ТВ-устройств Philips, продающихся в стране, были собраны в РФ.

В 2007 году Royal Philips Electronics первым из крупных производителей электроники перешел на прямой импорт, позволивший федеральной таможенной службе снизить долю нелегально ввозимой в Россию продукции.

В 2008 году Страшнов был назначен вице-президентом и генеральным директором Philips Consumer Lifestyle.

Работа в Tele 2
В апреле 2009 года назначен операционным директором, а в июле 2009 занял пост президента и генерального директора Tele2 Россия. Вошёл в менеджмент-борд Теле 2 АВ в качестве исполнительного вице-президента группы. За время его управления компанией число абонентов Tele2 в России выросло более чем вдвое – с 10 млн до 22,5 млн, а годовая выручка российского подразделения – с 25 млрд руб. до 52 млрд руб. В 2012 году доля "Tele 2 Россия" составляла около 30% в бизнесе группы, при этом российское подразделение приносило более 45% общей EBITDA Теле2 AB .

Страшнов активно лоббировал внедрение принципа технологической нейтральности и возможность переноса мобильных номеров. В конце 2013 года был принят закон о технологической нейтральности, а также было отменено "мобильное рабство".

31 декабря 2012 года Страшнов покинул Теле 2 AB. Причиной называют  возможный конфликт интересов: на фоне подготовки сделки о слиянии Tele2  и Ростелекома в СМИ появилась информация со ссылкой на источники в правительстве о возможном назначении Страшнова следующим главой Ростелекома.

Во главе «Почты России»
19 апреля 2013 года назначен генеральным директором ФГУП «Почта России», когда в аэропортах Москвы скопилось 500 тонн входящей необработанной почты. За два месяца новой команде удалось наладить логистику и восстановить международный почтовый обмен, благодаря тесному сотрудничеству с ФТС. Больше подобных кризисов в «Почте России» не происходило, даже несмотря на десятикратный рост международных отправлений с 2013 по 2017 год.

С 2013—2017 год «Почта России» наладила партнёрство с ведущими мировыми почтовыми операторами, такими как Deutsche Post, «Почта Китая», Japan Post и т. д.

С 2015 по 2017 год более чем в два раза были сокращены потери, которые «Почта России» несла из-за неоплаченной корреспонденции — так называемой «серой почты».

В связи с ростом электронной торговли между Китаем и Россией, был запущен почтовый поезд Москва-Пекин и приобретены грузовые самолеты. В 2013 году во Внуково был запущен самый большой в Европе почтовый логистический центр , в 2016 году был построен логистический центр в Казани.

С 2013 по 2017 год «Почта России» дважды повысила зарплату линейным сотрудникам. Средняя заработная плата выросла на 36 % — с 15,3 тыс. до 20,9 тыс. рублей.Оклад Страшнова в 2013 году составил 230 тыс. рублей в месяц без учёта надбавки за допуск к секретным сведениям, что составляет ещё 50 % от ежемесячного оклада.

C 2014 года Правительство РФ отменило субсидирование подписки и выпадающего дохода от предоставления почтовых услуг (убыточных для «Почты России») по тарифам, регулируемым государством. При этом «Почта России» осталась прибыльной без госдотаций в том числе за счет перехода на рыночные тарифы в коммерческих сегментах: посылки, подписка, аренда почтовых абонементных ящиков и т. д.

В 2016 году совместно с группой ВТБ был создан «Почта Банк». После многократных попыток, которые предпринимались ещё с 1990-х гг., «Почта России» успешно запустила проект банковской сети на базе своих отделений. В январе 2016 года Страшнов вошёл в состав наблюдательного совета ПАО «Почта Банк».

Расследование по фактам выплаты многомиллионной премии
В конце ноября 2016 года в отношении Страшнова начата доследственная проверка по факту начисления и выплаты ему в 2014 году бонуса-вознаграждения в размере 95,4 млн рублей. По оценке Генпрокуратуры, премия Страшнова должна была составлять 3,2 млн руб. Ведомство полагало, что выплата гендиректору бонуса по результатам финансовой деятельности «Почты России» нанесла существенный вред государственному унитарному предприятию. По версии прокуратуры в 2014 году «Почта России» получила убыток на 4 млрд рублей. Прибыль в 1,4 млрд рублей получилась благодаря тому, что «Почта России» в 2014 году получила из федерального бюджета целевой финансирование в размере 5,4 млрд рублей. Генпрокуратура направила материалы проверки в отношении двух директоров департаментов Минкомсвязи России, принимавших решение о выплате премии, в Следственный комитет РФ для оценки наличия признаков преступления. Страшнов в комментарии СМИ заявил: «Во всех действиях, связанных с расчетом вознаграждения, и "Почта России", и министерство связи руководствовались только законными актами. Эти акты применимы для всех госкомпаний.» Минкомсвязь обратила внимание на некорректность расчётов Генпрокуратуры в отношении премии главы «Почты России». В феврале 2017 года глава Минкомсвязи России Николай Никифоров заявил, что Страшнов работает эффективно, а само предприятие развивается энергично. Вице-премьер Дворкович сообщил, что премия главе «Почты России» была начислена в рамках закона.

22 февраля 2017 Генпрокуратура потребовала от Следственного комитета Российской Федерации возбудить уголовное дело против руководства «Почты России». По мнению надзорного ведомства Страшнов, будучи единоличным руководителем с персональной ответственностью и зная о поступлениях в 2014—2015 годах из федерального бюджета целевого финансирования на сумму 6,462 млрд рублей, вопреки законным интересам «Почты России» премировал своих заместителей на общую сумму 269,3 млн рублей.

15 марта 2017 года Следственный комитет Российской Федерации возбудил уголовное дело в отношении главы департамента Минкомсвязи России Ирины Лаптевой по фактам незаконной выплаты Страшнову зарплаты и премий в соответствующих размерах. В рамках этого дела 95 млн рублей премии на счетах Страшнова были арестованы судом, но в январе 2018 года возвращены Страшнову. Спустя полгода после ухода Страшнова из «Почты России» дело против Лаптевой было прекращено в связи с отсутствием состава преступления.

24 июля 2019 года Lenta.ru ссылаясь на анонимный Telegram-канал, сообщила о том, что Следственный комитет начал новую проверку о выплате премий заместителям Страшнова.

Уход из «Почты России»
30 июня 2017 года покинул пост генерального директора «Почты России» по истечении срока контракта. 19 июля 2017 года премьер-министр России Дмитрий Медведев наградил почётной грамотой правительства РФ Дмитрия Страшнова «за достигнутые трудовые успехи и большой вклад в развитие почтовой связи».

В сентябре 2017 года вошёл в состав директоров российского медиахолдинга «РБК».

Еврохим
С ноября 2017 года стал операционным директором группы «Еврохим», одного из крупнейших производителей удобрений в мире; активы компании расположены в России, Китае, Бельгии, Литве и других странах. Страшнов отвечал за оперативное управление глобальным бизнесом и работал в Швейцарии.

С 1 июля 2018 года назначен главным исполнительным директором EuroChem Group AG («Еврохим»).

24 сентября 2018 года покинул группу «Еврохим» в связи с личными обстоятельствами.

Примечания

Ссылки

 Биография Дмитрия Страшнова

Выпускники МГТУ
Родившиеся в Москве
Предприниматели России
Управленцы России
Персоналии:Почта России

redpajama_set_name: RedPajamaWikipedia


I am reproducing a long winded thesis I wrote on StackOverflow about the appropriate data schemata to facilitate OLAP. I wrote it because OLAP vendors are plain lazy to provide hooks to allow flexible and fast cube generation. OLAP at its current status is useless for engineers and good only for mesmerizing managers and their secretaries with imprecise and out-of-phase information. OLAP software writers seem to be so excited about their multi-dimensional Entity-Relationship schema designing skills, but never thought it necessary to optimise the flexibility and response of their cube building processes. Their response has always been, "Duh, it's OLAP, it takes time to build a cube. OLAP is not meant to be real-time."
As a generalisation, for multiple dimensional analysis to be effective you need two levels data modelling.
The answer is indeed EAV as the substrate detail capture. People can afford to be lazy and skip the detail substrate design. Every data mining tool I had been forced (by management) to evaluate has been inadequate because the inability to perform time-profiling.
Ultimately, it required us to write our own data-mining application - because the amount of kludge to make the software work, albeit ineffectively, equals to the amount of effort it takes to create one that works effectively. And even works extra-ordinarily spectacularly when we fed slices of the abstract cube into SAS/Insight. While the vendors' software took an hour to build the cube, and sometimes 24 hours, we needed our cubes to be built within 5 minutes and frequently within 15 seconds - due to effective substrate data modelling to enable efficient slicing of data to build the cube.
In industrial practice, we might need to flexibly move and range the time window of an analysis to match conditions that occured 6 months ago. Or that, we need to review the performance of processes for the last financial year.
We need to have correct time-phase correlation. Let's say a church has a per night statistic for a particular evangelistic rally as number of people "saved", number of "rededications", number of "contribution$", total contribution$, number of attendance - over 10 nights of the rally.
Then the church has statistics for number of tracts distributed by volunteer and the location each volunteer was assigned, the radio and tv advertisements and google ads placed. So the church statistician would need to collect info from each convert and $contributor - location of residence, when and where a tract was received, when and where an advertisement was encountered. And if they could collect such information from everyone who attended and who told them about it and when and where those who told them about the rally received a tract or encountered an advertisement. With such info at hand, the statistician would then be able a more truthfully matched multi-dimensional cube to let church leaders decide how to effectively organise their future pre-rally out-reach.
Data model optimization may not be possible for churches but for it is very possible for a factory full of equipment, robots, and trained operators. It is extraordinarily helpful to get phase-correlated data to treat an epidemic.
The EAV model is necessary because the number of parameters collectible, and number of attributes, vary from equipment to equipment and from process to process and from disease to disease. We cannot afford to have a table each for each set of parameters. Frequently a process or piece of equipment collects different sets of parameters, depending on the product that is being processed.
Sometimes the number of parameters collected can number a thousand. We cannot have a table with a thousand columns, can we? We even violate data normalization principles to store data in a single row or in a blob because of inefficient data access in a highly normalized table.
Further, we also need to version our data set. Let us say we designed an experiment for 2004. In 2006, we discovered that we needed to include new dimensions and discard some useless dimensions, and so we created a new version of the experiment. Then when we analyse the performance of the experiment between 2002 and 2008, we need to provide proper treatment to the change in the sets of dimensions in the experiment. In biological experiments and social behaviour surveys, the version changes would be more frequent.
I have a relational model of variable-dimensionality for attributes and parameters here:http://appdesign.blessedgeek.com/discrete-flow-resource-management. Not exactly EAV, but gives an idea what industrial multi-dimensional data modelling entails.


UC Browser is published since February 18, 2018 and is a great software part of Browsers subcategory. It won over 87,145 installations all time and 4,103 last week. It is obtainable for Windows and the interface is in English.
The program was produced by UCWeb Inc. and has been revised on February 11, 2019. It is a small tool (1701776 bytes) and does not need too much space than the rest of the products listed on Browsers.	It is highly used in India, United States of America and Japan.
After you get the 1,62 MB (UCBrowser_V7.0.185.1002_windows_pf101_(Build18010215).exe) installation file double click on the executable (.exe) file. Then follow the setup steps.


text:
/**
 * This code is released under the
 * Apache License Version 2.0 http://www.apache.org/licenses/.
 *
 * (c) Daniel Lemire, http://lemire.me/en/
 */

#ifndef SIMDPFOR_H_
#define SIMDPFOR_H_

#include "common.h"
#include "codecs.h"
#include "usimdbitpacking.h"
#include "util.h"

namespace FastPFor {

/**
 * This implements as best as possible the PFor scheme
 * from  Zukowski et al., Super-Scalar RAM-CPU Cache Compression
 * with SIMD acceleration.
 *
 *  Implemented by D. Lemire
 *
 * Small differences:
 *  1. We don't write the exception section is reverse order.
 *     It is written in forward order.
 *
 *  2.  Obviously, the code is specific to 32-bit integers whereas
 *      the original description allowed for different data types.
 *
 *  3. Because we assume pfor delta, we don't compute the base (that is
 *     the frame). Correspondingly, we don't sort a sample. Instead,
 *     we use a fast approach to identify the best number of bits
 *     based on the computation of the integer logarithm.
 *
 *  4. Though it is not clear how the sample is taken in the original
 *     paper, we consider a consecutive sample of up to 64K samples.
 *
 */
class SIMDPFor: public IntegerCODEC {
public:
    enum {
        BlockSizeInUnitsOfPackSize = 4,
        PACKSIZE = 32,
        BlockSize = BlockSizeInUnitsOfPackSize * PACKSIZE,
        blocksizeinbits = 7//constexprbits(BlockSize)
    };
    // these are reusable buffers
    std::vector<uint32_t> codedcopy;
    std::vector<uint32_t> miss;
    typedef uint32_t DATATYPE;// this is so that our code looks more like the original paper

    SIMDPFor() :
        codedcopy(BlockSize), miss(BlockSize) {
    }
    // for delta coding, we don't use a base.
    static uint32_t determineBestBase(
            const DATATYPE * in, size_t size) {
        if (size == 0) return 0;
        const size_t defaultsamplesize = 64 * 1024;
        // the original paper describes sorting
        // a sample, but this only makes sense if you
        // are coding a frame of reference.
        size_t samplesize = size > defaultsamplesize ? defaultsamplesize : size;
        uint32_t freqs[33];
        for (uint32_t k = 0; k <= 32; ++k)
            freqs[k] = 0;
        // we choose the sample to be consecutive
        uint32_t rstart = size > samplesize ? ( rand() % (static_cast<uint32_t>(size - samplesize)) ) : 0U;
        for (uint32_t k = rstart; k < rstart + samplesize; ++k) {
            freqs[asmbits(in[k])]++;
        }
        uint32_t bestb = 32;
        uint32_t numberofexceptions = 0;
        double Erate = 0;
        double bestcost = 32;
        for (uint32_t b = bestb - 1; b < 32; --b) {
             numberofexceptions += freqs[b + 1];
             Erate = static_cast<double>(numberofexceptions) / static_cast<double>(samplesize);
            /**
            * though this is not explicit in the original paper, you
            * need to somehow compensate for compulsory exceptions
            * when the chosen number of bits is small.
            *
            * We use their formula (3.1.5) to estimate actual number
            * of total exceptions, including compulsory exceptions.
            */
            if(numberofexceptions > 0) {
              double altErate = (Erate * 128 - 1) / (Erate * (1U<<b));
              if(altErate > Erate) Erate = altErate;
            }
            const double thiscost = b + Erate * 32;
            if (thiscost <= bestcost) {
                bestcost = thiscost;
                bestb = b;
            }
        }
        return bestb;
    }

    // returns location of first exception or BlockSize if there is none
    uint32_t compressblockPFOR(const DATATYPE * __restrict__ in,
            uint32_t * __restrict__ outputbegin, const uint32_t b,
            DATATYPE * __restrict__ & exceptions) {
        if (b == 32) {
            for (size_t k = 0; k < BlockSize; ++k)
                *(outputbegin++) = *(in++) ;
            return BlockSize;
        }
        size_t exceptcounter = 0;
        const uint32_t maxgap = 1U << b;
        {
            std::vector<uint32_t>::iterator cci = codedcopy.begin();
            for (uint32_t k = 0; k < BlockSize; ++k, ++cci) {
                miss[exceptcounter] = k;
                exceptcounter += (in[k] >= maxgap);
            }

        }
        if (exceptcounter == 0) {
            packblock(in, outputbegin, b);
            return BlockSize;
        }
        codedcopy.assign(in,in+BlockSize);
        uint32_t firstexcept = miss[0];
        uint32_t prev = 0;
        *(exceptions++) = codedcopy[firstexcept];
        prev = firstexcept;
        if (maxgap < BlockSize) {
            for (uint32_t i = 1; i < exceptcounter; ++i) {
            	uint32_t cur = miss[i];
                // they don't include this part, but it is required:
                while (cur > maxgap + prev) {
                    // compulsory exception
                    uint32_t compulcur = prev + maxgap;
                    *(exceptions++) = codedcopy[compulcur];
                    codedcopy[prev] = maxgap - 1;
                    prev = compulcur;
                }
                *(exceptions++) = codedcopy[cur];
                codedcopy[prev] = cur - prev - 1;
                prev = cur;
            }
        } else {
            for (uint32_t i = 1; i < exceptcounter; ++i) {
            	uint32_t cur = miss[i];
                *(exceptions++) = codedcopy[cur];
                codedcopy[prev] = cur - prev - 1;
                prev = cur;
            }
        }
        packblock(&codedcopy[0], outputbegin, b);
        return firstexcept;
    }

    void packblock(const uint32_t * source, uint32_t * out, const uint32_t bit) {
        usimdpack(source,reinterpret_cast<__m128i *>(out), bit);
    }

    void unpackblock(const uint32_t * source, uint32_t * out,
            const uint32_t bit) {
        usimdunpack(reinterpret_cast<const __m128i *>(source),out, bit);
    }

    void encodeArray(const uint32_t *in, const size_t len, uint32_t *out,
            size_t &nvalue) {
        *out++ = static_cast<uint32_t>(len);
#ifndef NDEBUG
        const uint32_t * const finalin(in + len);
#endif
        const uint32_t maxsize = (1U << (32 - blocksizeinbits - 1));
        size_t totalnvalue(1);
        //for (size_t i = 0; i < len; i += maxsize)
        for (size_t j = 0; j < (len+maxsize-1U)/maxsize; ++j) {
            size_t i = j << (32 - blocksizeinbits - 1);
            size_t l = maxsize;
            if (i + maxsize > len) {
                l = len - i;
                assert(l <= maxsize);
            }
            size_t thisnvalue = nvalue - totalnvalue;
            assert(in + i + l <= finalin);
            __encodeArray(&in[i], l, out, thisnvalue);
            totalnvalue += thisnvalue;
            assert(totalnvalue <= nvalue);
            out += thisnvalue;
        }
        nvalue = totalnvalue;
    }
    const uint32_t * decodeArray(const uint32_t *in, const size_t len,
            uint32_t *out, size_t &nvalue) {
        nvalue = *in++;
        if (nvalue == 0)
            return in;
#ifndef NDEBUG
        const uint32_t * const initin = in;
#endif
        const uint32_t * const finalin = in + len;
        size_t totalnvalue(0);
        while (totalnvalue < nvalue) {
            size_t thisnvalue = nvalue - totalnvalue;
#ifndef NDEBUG
            const uint32_t * const befin(in);
#endif
            assert(finalin <= len + in);
            in = __decodeArray(in, finalin - in, out, thisnvalue);
            assert(in > befin);
            assert(in <= finalin);
            out += thisnvalue;
            totalnvalue += thisnvalue;
            assert(totalnvalue <= nvalue);
        }
        assert(in <= len + initin);
        assert(in <= finalin);
        nvalue = totalnvalue;
        return in;

    }

    void __encodeArray(const uint32_t *in, const size_t len, uint32_t *out,
            size_t &nvalue) {
        checkifdivisibleby(len, BlockSize);
        const uint32_t * const initout(out);
        std::vector<DATATYPE> exceptions;
        exceptions.resize(len);
        DATATYPE * __restrict__ i = &exceptions[0];
        const uint32_t b = determineBestBase(in,len);
        *out++ = static_cast<uint32_t>(len);
        *out++ = b;
        for (size_t k = 0; k < len / BlockSize; ++k) {
            uint32_t * const headerout(out);
            ++out;
            uint32_t firstexcept = compressblockPFOR(in, out, b, i);
            out += (BlockSize * b) / 32;
            in += BlockSize;
            const uint32_t bitsforfirstexcept = blocksizeinbits;
            const uint32_t firstexceptmask = (1U << blocksizeinbits) - 1;
            const uint32_t exceptindex = static_cast<uint32_t>(i - &exceptions[0]);
            *headerout = (firstexcept & firstexceptmask) | (exceptindex
                    << bitsforfirstexcept);
        }
        const size_t howmanyexcept = i - &exceptions[0];
        for (uint32_t t = 0; t < howmanyexcept; ++t)
            *out++ = exceptions[t];
        nvalue = out - initout;
    }

#ifndef NDEBUG
    const uint32_t * __decodeArray(const uint32_t *in, const size_t len,
#else
    const uint32_t * __decodeArray(const uint32_t *in, const size_t    ,
#endif
            uint32_t *out, size_t &nvalue) {
#ifndef NDEBUG
        const uint32_t * const initin(in);
#endif
        nvalue = *in++;
        checkifdivisibleby(nvalue, BlockSize);
         const uint32_t b = *in++;
        const DATATYPE * __restrict__ except = in + nvalue * b / 32 + nvalue
                / BlockSize;
        const uint32_t bitsforfirstexcept = blocksizeinbits;
        const uint32_t firstexceptmask = (1U << blocksizeinbits) - 1;
        const DATATYPE * endexceptpointer = except;
        const DATATYPE * const initexcept(except);
        for (size_t k = 0; k < nvalue / BlockSize; ++k) {
            const uint32_t * const headerin(in);
            ++in;
            const uint32_t firstexcept = *headerin & firstexceptmask;
            const uint32_t exceptindex = *headerin >> bitsforfirstexcept;
            endexceptpointer = initexcept + exceptindex;
            uncompressblockPFOR(in, out, b, except, endexceptpointer,
                    firstexcept);
            in += (BlockSize * b) / 32;
            out += BlockSize;
        }
        assert(initin + len >= in);
        assert(initin + len >= endexceptpointer);
        return endexceptpointer;
    }
    void uncompressblockPFOR(
            const uint32_t * __restrict__ inputbegin,// points to the first packed word
            DATATYPE * __restrict__ outputbegin, const uint32_t b,
            const DATATYPE *__restrict__ & i, // i points to value of the first exception
            const DATATYPE * __restrict__ end_exception, size_t next_exception // points to the position of the first exception
            ) {
        unpackblock(inputbegin, reinterpret_cast<uint32_t *> (outputbegin), b); /* bit-unpack the values */
         for (size_t cur = next_exception; i != end_exception; cur
                = next_exception) {
            next_exception = cur + static_cast<size_t> (outputbegin[cur]) + 1;
            outputbegin[cur] = *(i++);
        }
    }

    virtual std::string name() const {
        std::ostringstream convert;
        convert << "SIMDPFor";
        return convert.str();
    }

};

} // namespace FastPFor

#endif /* PFOR_H_ */

redpajama_set_name: RedPajamaGithub


Rep. Raul Ruiz and challenger Kimberlin Brown Pelzer have been trading barbs over immigration, taxes and each others' records on the campaign trail for more than a year, but before last week, had yet to discuss the issues animating the race face-to-face.
The two candidates vied Thursday for an endorsement from the media company's editorial board, which has endorsed Ruiz's candidacy in the past three elections.
Ruiz, a Democrat from Coachella, and Brown Pelzer, a Republican actress-businesswoman from Palm Springs, answered questions on issues ranging from taxes to immigration to health care. Ruiz summarized his record of achievements and bills he's contributed to while in Congress, while Brown Pelzer highlighted her experiences as a businesswoman and said Ruiz had failed to distinguish himself during his three terms in office.
Ruiz and Brown Pelzer diverged on the recent tax cuts.
The congressman said cuts have disproportionately benefited the wealthy at the expense of the middle class. Brown Pelzer, citing her experiences as a business owner, said the tax cuts had allowed businesses to grow and decreased unemployment. If elected to Congress, she said she would advocate making the cuts permanent.
Both candidates said they support enhancing the technological capabilities of border patrol agents, but clashed over the ongoing construction of a border wall.
"I don't support a border wall because it'll be ineffective, a waste of taxpayer dollars, and was borne in a politics of hatred," Ruiz said.
Building a wall, Brown Pelzer said, would curb human trafficking and drug smuggling by limiting the passage of goods and people to checkpoints.
"If you narrow access points, you force illegal traffic in one direction. It'll cut down on the problem," she said.
Ruiz and Brown Pelzer expressed different views on gun control and the #MeToo movement.
Brown Pelzer said her support of the Second Amendment and her feeling that women need to be protected stems from personal experience. Brown Pelzer said she slept with a gun beside her for three years after a series of events — that she did not describe —made her fear for her life.
Brown Pelzer said the #MeToo movement brought up real concerns about women's safety that she felt particularly strongly about because her daughter was a victim of sexual violence. But she also called into question the political motives behind the #MeToo movement, which she said merited a government investigation.
Ruiz said his perspective on guns and sexual violence is based on his experience as an emergency room doctor, where he cared for patients with gunshot wounds and also victims of sexual violence.
He said he would push for Center for Disease Control funding that would allow the agency to research gun violence as a public health issue and close loopholes that allow for the purchase of firearms at gun shows and on the internet without background checks.
In light of the #MeToo movement and high-profile allegations of sexual violence, Ruiz said lawmakers should strengthen anti-harassment training and education requirements in businesses.
The session became heated after Ruiz attacked Brown Pelzer for echoing Trump's comments on the media, citing a speech she made in Banning.
Brown Pelzer has repeatedly claimed the press is against her since a July Desert Sun article called into question an assertion she made about Ruiz's record and the number of bills he had passed. Even though the remarks Ruiz cited can be seen on her public Facebook page, she told the Editorial Board she did not make the statements.
Brown Pelzer and Ruiz disagree on when members of Congress can count bills and amendments they author as their own. Ruiz told the Editorial Board that seven bills and two amendments he authored have been enacted into law. Brown Pelzer responded that she and her staff had not been able to find evidence of the bills.
The different counts stem from the candidates' disagreement about which bills Ruiz could count as his own. The congressman said it is regular procedure in the House of Representatives for bills to be enacted into law through becoming parts of larger bill packages.
Brown Pelzer said politicians could only count bills as their own if they're listed on the legislation when it's signed by the president. Under her own rubric, Brown Pelzer's statement is accurate; no bill that Ruiz has served as primary author on has been signed by the president.
But to residents affected by legislation, Ruiz said, the content of final bills is more important than the author listed. Bills he introduced that were later passed as part of larger bill packages with his original text intact include H.R. 1183, his 2017 Wildfire Prevention Act that was passed into law as part of the 2018 Bipartisan Budget Act, which brought funds to small communities ravaged by wildfires like Idyllwild, he said.


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The Brexit countdown is ticking away despite the lack of action in Westminster – and with three weeks to go, a no deal split looks on the cards.
MPs just cannot stop squabbling about how unacceptable the deal on the table is, but after two years still cannot settle on an alternative.
The latest is European Union officials are frustrated at the lack of progress and warned Prime Minister Theresa May that if she can't put forward a feasible alternative to the current agreement within 48 hours, there's no time to change the wording that MPs will vote on next week.
Tuesday sees the second 'meaningful' vote in Westminster, but the word is May expects to lose by around 100 votes and may be planning a third vote a few days later.
All the while, the Brexit clock is counting down and precious little time is left to make a deal before the UK clocks out of Europe for the last time on March 29.
So what are the Brexit options?
May has turned down a delay, but could yet see her hand forced by MPs.
"If the prime minister's deal does not get approved on Tuesday then it is likely that the House of Commons will vote to extend the Article 50 procedure, to not leave the European Union without a deal, and where we go thereafter is highly uncertain," said Chancellor Phillip Hammond.
French Europe minister Nathalie Loiseau reiterated the EU's position that the withdrawal agreement cannot be reopened and said the deal was the "best possible solution" with the controversial Irish backstop a "last resort solution".
Next articleHow Does The State Pension Rank Where You Live?
How Do No-Frills Airlines Make Their Money?
Is Consolidating Pensions Worth The Bother?
Money International is one of the world's leading resources for cross border financial news and information.


Help Charlie Heal: Charlie is Home!
Charlie had a good night. He ate small meals and was able to keep everything down. His pain medication doses became more and more spread out and he actually slept for normal stretches during the night. This morning he was looking good and ready for his first full bottle since having surgery less than 48 hours ago. His eyes are still swollen shut and probably will be for a few more days.
Dr. Fearon and Dr. Sacco came for a short visit this morning and determined that he looked "awesome" and that we could "pack it up" and go home. Home? Yes! Home! By 10am this morning, Charlie was home and happy to be so. When Jack and I entered the house, Charlie heard the familiar sounds of our sticky front door, our beeping house alarm and keys hitting the dining room table. He picked his head up off of my shoulder, smiled and let out the first giggle we've heard all day. Jack and I cannot thank you enough for your prayers and healing thoughts. Charlie's surgery and recovery went even better than we could have imagined. He did everything quickly, smoothly and ahead of schedule. We are amazed.
Charlie last night before bed time.
Charlie taking his first full bottle this morning.
Jack and Charlie take a spin around the ward in a Red Flyer wagon while waiting for discharge.
Charlie having his second meal of the day at home in his Daddy's arms.
what a beautiful sight! welcome home, big guy!
These great photos make it real! So glad this hurdle has been jumped successfully and you are now home. Lots of love!!!
So happy to hear that he's doing well!
so glad eveything went well! I truly rejoice. Please, as this is a learning opportunity for me too, could you pls give some details about the surgery. How come they didn't have to shave his little cute head? Hope you don't mind my asking.
AWESOME! So glad Charlie is home!! Lots of love to your sweet boy and the whole family during this time of recovery and healing!
Happy & amazed at Charlie's recovery. Photos are terrific. Thanks for keeping us up to date!


text:
Facebook page opens in new windowTwitter page opens in new windowMail page opens in new window
Signature Physician Careers
Physician Recruitment and Employment
Letter From Our President and Chief Executive Officer
About Us PDF
Welcome To The Area
Welcome To Boston
Welcome To Signature Healthcare
Our team approach is the way healthcare should be: medical professionals across many locations communicating and collaborating, taking advantage of technologies and resources to make a difference in the lives of our patients.
The Signature Healthcare is comprised of:
Signature Healthcare Brockton Hospital (245 bed community hospital)
Signature Medical Group (150 employed physicians)
Signature Healthcare Brockton Hospital School of Nursing
The organization includes 550 affiliated physicians and other direct care providers, 150 employed physicians and 2,700 associates operating from Massachusetts locations in: Abington, Bridgewater, Brockton, Hanson, Easton, Randolph, and Raynham.
Signature Healthcare Brockton Hospital
Founded as Brockton Hospital in 1896, the Hospital is the oldest and largest inpatient facility in its service area, which is designated as the city of Brockton and twenty-one surrounding municipalities. We strive to be recognized as the "providers of choice" by staff, patients, and the community.
We are a community-based non-profit teaching hospital, providing a full range of clinical services. We maintain a major teaching affiliation with Beth Israel Deaconess Medical Center, and are fully accredited by the Joint Commission on Accreditation of Healthcare Organizations. We are a member of the Massachusetts Hospital Association and the American Hospital Association.
The hospital has 245 licensed beds, including a 29-bed hospital-based skilled nursing unit. Operation of this Transitional Care Unit began in 1997. In addition to providing medical/surgical, pediatric and obstetric services, the hospital offers inpatient and outpatient psychiatry, radiation oncology, cardiac catheterization, Level II nursery, and magnetic resonance imaging.
Signature Medical Group
Signature Medical Group (SMG) provides comprehensive healthcare services to patients of all ages, including primary care, more than 17 specialties, women's health, Urgent Care, and diagnostic care. SMG offers patients full scale lab and radiology services, including CAT Scan, Bone Density and Mammography. For over forty years, Signature Medical Group has been committed to providing quality care to patients in Greater Brockton and its surrounding communities.
Brockton Hospital School of Nursing
Brockton Hospital School of Nursing (BHSN), a private co-educational institution of nursing education, is an integral part of Signature Healthcare Brockton Hospital. Originally established in 1897, BHSN has a prestigious reputation in nursing education, and remains the only hospital-based nursing school in the state of Massachusetts. BHSN has graduated over 2,000 nurses, mainly from southeastern Massachusetts.
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Signature Healthcare is an Equal Opportunity Employer. Women and Minorities are strongly encouraged to apply.
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redpajama_set_name: RedPajamaCommonCrawl


My mother told me he was in heaven with God.
on the swing set while alone.
He was a good, invisible father.
Then my friend invited me to church.
That's God's house, she said.
I told my mother I wanted to go.
for birthday parties, Friday nights, Chanukah.
an angel in God's house.
perched on the pew anticipating our host.
and read. He yelled. We sang.
The organ played, people knelt.
and the statue of the man on the cross.
I was worried for the man. The people.
That night my mother read me a story.
than I had ever been.


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text:
Level 11, 15 Blue Street
Companies & Associations
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Loans, Mortgages & Securities
Taxation & Stamp Duty
Trusts & Trust Litigation
Wills, Powers of Attorney, Guardianships
Margaret Antunes
Keith Reddy
Kathy Chase
Maria Tzannes
Tim Arvanitis
Lindy Palmer
Stefan Stojkovic
Victoria Carollo
Claire Shulver
Boris Jakimov
Sara Duong
News and Legal Information
Companies and associations have a lot to think about when it comes to the company law side of business. Aside from designing the legal structures of the business and making sure you've got adequate asset protection in place, you need to consider other legal matters such as tax, regulations and risk.
At Antunes Lawyers in Sydney, we provide a full range of company law services for companies and associations. We can incorporate companies and provide shareholders agreements or joint venture agreements – to create a business vehicle best suited to meet all commercial challenges. If it becomes necessary we can re-design the legal structures of the business or other entity to meet new circumstances and ensure asset protection. We can also arrange the purchase and sale of shares in private companies separately or in conjunction with a sale of a business.
Our lawyers are experienced in dealing with corporate governance and cases where shareholders or members of a joint venture are being taken advantage of by others. We can also advise on meeting procedures including for associations under the Incorporated Associations Act.
Shelf companies are often not suitable for the circumstances of the owners, as they develop. They contain impractical and sometimes uncommercial terms that owners are not aware of until they are in dispute. At this stage, it's too late to amend the legal structures of the business to include asset protection, which can cause significant grief to the owners and their families and often lead to loss of the business. Company constitutions should be tailored to the circumstances of the business owners and the business itself, now and into the future. For this reason, Antunes Lawyers incorporates companies and drafts company constitutions suitable for the particular shareholders and the business.Incorporation of Companies and Associations
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Talk to one of our lawyers specialising in business structuring, asset protection and joint venture agreement by calling Antunes Lawyers in Sydney on 02 9964 0499 today.
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text:
"""Generate graphs with given degree and triangle sequence.
"""
#    Copyright (C) 2004-2011 by
#    Aric Hagberg <hagberg@lanl.gov>
#    Dan Schult <dschult@colgate.edu>
#    Pieter Swart <swart@lanl.gov>
#    All rights reserved.
#    BSD license.
import random
import networkx as nx
__author__ = "\n".join(['Aric Hagberg (hagberg@lanl.gov)',
                        'Joel Miller (joel.c.miller.research@gmail.com)'])

__all__ = ['random_clustered_graph']

def random_clustered_graph(joint_degree_sequence, create_using=None, seed=None):
    """Generate a random graph with the given joint degree and triangle
    degree sequence.

    This uses a configuration model-like approach to generate a
    random pseudograph (graph with parallel edges and self loops) by
    randomly assigning edges to match the given indepdenent edge
    and triangle degree sequence.

    Parameters
    ----------
    joint_degree_sequence : list of integer pairs
        Each list entry corresponds to the independent edge degree and
        triangle degree of a node.
    create_using : graph, optional (default MultiGraph)
        Return graph of this type. The instance will be cleared.
    seed : hashable object, optional
        The seed for the random number generator.

    Returns
    -------
    G : MultiGraph
        A graph with the specified degree sequence. Nodes are labeled
        starting at 0 with an index corresponding to the position in
        deg_sequence.

    Raises
    ------
    NetworkXError
        If the independent edge degree sequence sum is not even
        or the triangle degree sequence sum is not divisible by 3.

    Notes
    -----
    As described by Miller [1]_ (see also Newman [2]_ for an equivalent
    description).

    A non-graphical degree sequence (not realizable by some simple
    graph) is allowed since this function returns graphs with self
    loops and parallel edges.  An exception is raised if the
    independent degree sequence does not have an even sum or the
    triangle degree sequence sum is not divisible by 3.

    This configuration model-like construction process can lead to
    duplicate edges and loops.  You can remove the self-loops and
    parallel edges (see below) which will likely result in a graph
    that doesn't have the exact degree sequence specified.  This
    "finite-size effect" decreases as the size of the graph increases.

    References
    ----------
    .. [1] J. C. Miller "Percolation and Epidemics on Random Clustered Graphs."
        Physical Review E, Rapid Communication (to appear).
    .. [2] M.E.J. Newman, "Random clustered networks".
        Physical Review Letters (to appear).

    Examples
    --------
    >>> deg_tri=[[1,0],[1,0],[1,0],[2,0],[1,0],[2,1],[0,1],[0,1]]
    >>> G = nx.random_clustered_graph(deg_tri)

    To remove parallel edges:

    >>> G=nx.Graph(G)

    To remove self loops:

    >>> G.remove_edges_from(G.selfloop_edges())

    """
    if create_using is None:
        create_using = nx.MultiGraph()
    elif create_using.is_directed():
        raise nx.NetworkXError("Directed Graph not supported")

    if not seed is None:
        random.seed(seed)

    # In Python 3, zip() returns an iterator. Make this into a list.
    joint_degree_sequence = list(joint_degree_sequence)

    N = len(joint_degree_sequence)
    G = nx.empty_graph(N,create_using)

    ilist = []
    tlist = []
    for n in G:
        degrees = joint_degree_sequence[n]
        for icount in range(degrees[0]):
            ilist.append(n)
        for tcount in range(degrees[1]):
            tlist.append(n)

    if len(ilist)%2 != 0 or len(tlist)%3 != 0:
        raise nx.NetworkXError('Invalid degree sequence')

    random.shuffle(ilist)
    random.shuffle(tlist)
    while ilist:
        G.add_edge(ilist.pop(),ilist.pop())
    while tlist:
        n1 = tlist.pop()
        n2 = tlist.pop()
        n3 = tlist.pop()
        G.add_edges_from([(n1,n2),(n1,n3),(n2,n3)])
    G.name = "random_clustered %d nodes %d edges"%(G.order(),G.size())
    return G


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text:
Q: Shutdown ExecutorService gracefully when main-thread completes In a utility library i am creating a ExecutorService
ExecutorService es = Executors.newSingleThreadExecutor();

The main thread will then post some tasks to this ExecutorService. When the main-thread completes i would like to shutdown the ExecutorService to allow the application to exit.
Problem is i can only change the code in the utility-library. One option I considered was to use daemon-threads. But then it will abruptly shutdown before the tasks posted to the service can complete.

A: Use Runtime#addShutdownHook() to add a shutdown hook to the current runtime.
E.g.
Runtime.getRuntime().addShutdownHook(new Thread() {
    public void run() {
        es.shutdown();
        try {
            es.awaitTermination(5, TimeUnit.SECONDS);
        } catch (InterruptedException e) {
            logger.info("during await",e);
        }
    }
});

Do this upon construction/initialization of your utility class.

A: shutdownHook will not work unless you make your executor a daemon thread. Here is the reason
shutdownhook is started when JVM starts exiting and JVM will not exit unless you call es.shutDown() so its a deadlock.
I dont know why making daemon executor didn't work. It should. A daemon executor will not shutdown until all threads started by the main class finished executing(unless they are also daemon)
try this code when creating executor
   ExecutorService es = Executors.newSingleThreadExecutor( new ThreadFactory() {
        @Override
        public Thread newThread(Runnable r) {
            Thread t = new Thread(r);
            t.setDaemon(true);
            return t;
        }
    });

redpajama_set_name: RedPajamaStackExchange


text:
Catalyst: Whitney Beltrán
New Modality Catalyst:
Whitney Beltrán, Game and Narrative Designer
Profile edited by Katie MacBride
Photo courtesy of Whitney Beltrán
Last update: February 19th, 2020
Whitney Beltrán, a.k.a. "Strix," is an award-winning writer and narrative designer for analog and video games, scripts and features, and transmedia. She is currently the project narrative director at the video game company Hidden Path Entertainment, and has worked with a variety of narrative and game studios including E-Line Media, Harebrained Schemes, Undead Labs, Onyx Path, Magpie Games, and Crackhorse Films. She is an expert in world-building and narrative design, and holds a Master's in Mythological Studies. She has published peer-reviewed academic papers on psychology and narrative play; contributed a chapter to a university textbook on role-playing games; and has conducted research through Carnegie Mellon's Human-Computer Interaction Institute on technology and live-action role-playing. Here's more about this Catalyst:
What's your quick bio?
I'm a diversity and inclusion consultant for game companies in areas like hiring practices and employee support, and also narrative inclusion and sensitivity reading for game story. I recently released my own multiple award-winning game, Bluebeard's Bride. I travel locally and internationally to conventions and academic conferences to present papers, lectures, and most importantly, play. I believe that narrative games — games that tell stories — can be transformative and powerful tools for learning and growth.
What are some of your own favorite past projects? Why do you feel great about them?
My favorite project to date is Bluebeard's Bride. It's a feminine horror storytelling game about the original Bluebeard fairytale, and I love how deeply it impacts the people who play it. I co-created Bluebeard's Bride with two other women, and I'm so proud that our vision came out crystal clear.
Also, have you seen the art? The art is gorgeous. [Editor's note: One of the contributing artists, Kring Demetrio, posted some interior illustrations here.]
What's a specific project that you're excited about *right now*?
My day job is directing the narrative of a AAA video game. It is incredibly exciting, but I can't say a word about it. However, I am working on a side project that also brings me much joy. It's a mobile AR hidden object game. It's got a vaporwave vibe, a surreal story, and yeah, also gorgeous art. Look out for it soon. It's called HoloVista.
Where can we follow you and your work?
My website: StrixWerks.com, or on Twitter @the_strix.
New Modality Catalysts
The New Modality is about experiments in culture — and the people who do those experiments. NewMo Catalysts are people who do things we admire and want to celebrate. They also help us stay accountable to our values. To learn more about NewMo Catalysts (or nominate someone to be a Catalyst), check out the Catalyst FAQ.
This profile was edited by Katie MacBride. Katie is a writer and co-founder of Anxy magazine. More about Katie at her NewMo profile
The information in our Catalyst profiles usually comes directly from the subjects, and we usually don't fact-check them. You can learn more about The New Modality's fact-checking and epistemological ideas by reading the page about our process for truth and transparency.


text:
100 Huntley Street - May 13, 2020
Kirk Cameron is a television and film actor and producer, noted recently for his new television series, One on One with Kirk Cameron (now available for streaming on the TBN Network) and his 32 city national marriage and family speaking tour called Living Room Reset http://kirkcameron.com/living-room-reset, as well as his documentaries CONNECT, UNSTOPPABLE and MONUMENTAL, and the inspirational film of year FIREPROOF. He is also known for his memorable roles on ABC's Growing Pains, the Left Behind movies, and co-host of The Way of the Master television series. Kirk spends much of his time producing new television and film projects and speaking to people around the country, teaching them how to share their faith and live out a gospel centered marriage and family. Kirk and his wife Chelsea are the founders of Camp Firefly, a camp for seriously ill children and their families. Together, they live in California with their six children. Kirk was not raised in a church-going home and describes himself as an atheist from a very young age. By the age of 14 he was so convinced there was no God that he laughed at those who said there was. But that all changed one afternoon as he sat in his sports car pondering the first Gospel message he had ever heard. http://kirkcameron.com
Hey Meisha! is a new biblical teaching variety show for kids, featuring Meisha and the Good News Kids. Makesh the Rapper, Joy the dancer, Addison the Baker and Keaton the Singer bring their unique, hilarious and curious perspective to learning about faith and values. Meisha will talk about upcoming Easter content (trivia, sketch comedy & storytelling), guess what viewers can expect from Hey Meisha! This year? How can Hey Meisha! And our Castle platform be a source of encouragement during this pandemic? http://heymeisha.com http://intothecastle.com
Jack Vanderkooy
Jack served as Chief Operating Officer for Crossroads Christian Communications and retired in 2019. Jack is now serving once again as one of the many amazing Crossroads volunteers who give their time to pray with you when you call into our prayer lines. http://crossroads.ca/247prayer/
Carolyn Klickerman
Carolyn is one of the many amazing Crossroads volunteers who give their time to pray with you when you call into our prayer lines. http://www.crossroads.ca/247prayer/ http://crossroads.ca/247prayer/
Sharon Langendoen-Arndt
Sharon serves as Crossroads Follow-up Ministry Representative - Pastoral Care Team and Volunteer Prayer Partner Administrative Support. http://100huntley.com
Karmyn Bokma
"Please Note: Today's Program originally aired on Jan 7, 2020 prior to physical distancing mandates" Karmyn Bokma is currently serving as the Lead Pastor at The Meeting House, Oakville, as well as serving as one of the teaching pastors. She is passionate about helping people discover, and understand more deeply, their identity in Christ. Nothing energizes her more than leading teams of people as they work and serve out of who God made them to be. Karmyn is married to Ben and they have three children: Elliana, Ezekiel and Silas.
Ray Wong
Constable Ray Wong talks with 100 Huntley Street's Mark Masri about the effects of Covid-19 as it relates to his work with Hamilton Police Service. Ray will share what he has observed in his work as it relates to anxiety, both in the community and within the Police Service, changes he ha...
Ann Johnston
Ann Johnston has been ministering on the Prayer lines for 37 years. She can share of many wonderful stories of lives that have been changed through the ministry.
Joel is the Chief Growth Officer for Crossroads Christian Communication Inc. http://intothecastle.com http://cr...
Kirk Cameron is a television and film actor and producer, noted recently for his new television series, One on One with Kirk Cameron (now available for streaming on the TBN Network) and his 32 city national marriage and family speaking tour called Living Room Reset http://kirkcameron...


Auto trans, with leather, with metal. This gear shift knob with Aluminum inlay provides a comfortable grip and a sporty appearance. Manual M66 transmission. Add a unique style to your interior with a an aluminum inlay gear selector knob. The inlay is a perfect match to the sport steering wheel giving the passage compartment a sporty look and feel. Available for manual and automatic vehicles. Fits AT only. The gear shift knob- in high quality leather with metal inlay- is not only attractive but also provides a comfortable grip. The knob is specially designed to match the sports steering wheel with metal inlay together with the gear shift boot and textile mat in the sports version. The metal finish is something that recurs in the cars interior so the gear shift knob is an ideal alternative for all interior equipment kits.


text:
Olivia Tjandramulia (* 11. Mai 1997 in Jakarta, Indonesien) ist eine australische Tennisspielerin.

Karriere
Tjandramulia spielt hauptsächlich auf der ITF Women's World Tennis Tour, auf der sie bislang zehn Doppeltitel gewann.
Tjandramulia gab ihr Debüt auf der WTA Tour 2014 beim Hobart International in der Doppelkonkurrenz, mit einer Wildcard ausgestattet verlor sie dort mit Partnerin Kimberly Birrell jedoch bereits die Auftaktpartie. Im Anschluss erhielt sie auch für den Doppelwettbewerb der Australian Open eine Wildcard, an der Seite von Naiktha Bains kam sie erneut nicht über die erste Runde hinaus.

Turniersiege

Doppel

Weblinks

Tennisspieler (Australien)
Australier
Geboren 1997
Frau


(BUSINESS WIRE)--TriMas Corporation (NASDAQ: TRS) – a diversified global manufacturer of engineered and applied products – announced today that its Cequent Performance Products electrical plant in Reynosa, Mexico, this month, passed the one millionth-hour mark – more than three years – without having an injury that resulted in a lost work day.
"This milestone is a reflection of the combined efforts of all employees at the Cequent Performance Products electrical plant in Reynosa, working together for a common goal – safety," said Tom Benson, president of Cequent Performance Products. "We are all pleased with this achievement and are committed to providing an environment that promotes continuous improvement in all we do."
Cequent is a leading designer, manufacturer and marketer of a broad range of accessories for light trucks, sport utility vehicles, recreational vehicles, passenger cars and trailers of all types. Products include cargo management and rack systems, towing and hitch systems, and trailer and electrical brake systems. Cequent draws upon a 75-year-old heritage of superior cargo management and recreational accessory brands, including: Bulldog®, ROLA®, Highland®, The Pro's Brand®, Draw-Tite®, Reese®, Hidden Hitch®, Fulton®, Wesbar®, and Tekonsha®.
Headquartered in Bloomfield Hills, Michigan, TriMas Corporation (NASDAQ: TRS) provides engineered and applied products for growing markets worldwide. TriMas is organized into six reportable segments: Packaging, Energy, Aerospace & Defense, Engineered Components, Cequent Asia Pacific and Cequent North America. TriMas has approximately 4,100 employees at more than 60 different facilities in 15 countries. For more information, visit www.trimascorp.com.


The Customer Support Representative reports directly to the Assistant Manager, and is responsible for providing support for all home delivery services for the designated market area. Position involves giving direction, and measuring success of the overall delivery operation in coordination with the Assistant Manager.
The Operations Manager position provides support to home delivery services for a designated market region. Position is responsible for managing daily operations of motor carriers. In addition, Operations Manager maintains positive and ongoing relationship with external customer and is responsible for generating positive customer satisfaction.he Operations Manager position provides support to home delivery services for a designated market region. Position is responsible for managing daily operations of motor carriers. In addition, Operations Manager maintains positive and ongoing relationship with external customer and is responsible for generating positive customer satisfaction.


Creates an empty message box.
Creates a message box with given caption, text, icon, and buttons.
Sets the text for the message box.
Returns the message box text.
Sets standard buttons for the message box.
Signal emitted when a button is clicked.
Returns whether the dialog can be closed.
Set the position of the widget at the mouse position.
Raises this dialog to be the top-most dialog.
Event signal emitted when a finger is placed on the screen.
Event signal emitted when a finger is removed from the screen.
Event signal emitted when a finger, which is already placed on the screen, is moved across the screen.
A standard dialog for confirmation or to get simple user input.
The messagebox shows a message in a dialog window, with a number of buttons. These buttons may be standard buttons, or customized.
A messagebox is (usually) modal, and can be instantiated synchronously or asynchronously.
When using a messagebox asynchronously, there is no API call that waits for the messagebox to be processed. Instead, the usage is similar to instantiating a WDialog (or any other widget). You need to connect to the buttonClicked() signal to interpret the result and delete the message box.
The synchronous use of a messagebox involves the use of the static show() method, which blocks the current thread until the user has processed the messabebox. Since this uses the WDialog::exec(), it suffers from the same scalability issues as well as limitations. See documentation of WDialog for more details.
When the button is clicked, the associated result will be returned.
Adds a custom button with given text.
Returns the button widget for the given standard button.
Returns 0 if the button isn't in the message box.
This may be useful to customize the style or layout of the button.
Returns the result of this message box.
This value is only defined after the dialog is finished.
Sets the button as the default button.
The default button is pressed when the user presses enter. Only one button can be the default button.
If no default button is set, Wt will take a button that is associated with a Wt::StandardButton::Ok or Wt::StandardButton::Yes result.
The default value is 0 (no default button).
The escape button is pressed when the user presses escapes.
If no escape button is set, Wt will take a button that is associated with a Wt::StandardButton::Cancel or Wt::StandardButton::No result.
Convenience method to show a message box, blocking the current thread.
Show a message box, blocking the current thread until the message box is closed, and return the result. The use of this method is not recommended since it uses WDialog::exec(). See documentation of WDialog for detailed information.
This may be useful to customize the style or layout of the displayed text.


Parsons, KS- The Tau Theta Chapter of Phi Theta Kappa at Labette Community College attended the PTK Regional Convention March 1-3 in Wichita, KS. The chapter earned numerous awards at the convention. In addition Tau Theta member, Robert Armstrong, was reelected as the Regional President for the 2019-2020 year. Phi Theta Kappa is by invitation only and is the national honor society of the two year college.
For more information about Phi Theta Kappa, email tammyf@labette.edu.


This is a placeholder page for Katie Bass, which means this person is not currently on this site. We do suggest using the tools below to find Katie Bass.
You are visiting the placeholder page for Katie Bass. This page is here because someone used our placeholder utility to look for Katie Bass. We created this page automatically in hopes Katie Bass would find it. If you are not Katie Bass, but are an alumni of El Reno High School, register on this site for free now.


High levels of extracellular xylanase activity (211.79 IU/mg) produced by Paenibacillus sp. NF1 were detected when it was submerged-cultured. After three consecutive purification steps using Octyl-Sepharose, Sephadex G75, and Q-Sepharose columns, a thermostable xylanase (XynNF) was purified to homogeneity and showed a molecular mass of 37 kDa according to SDS-PAGE. The specific activity of the purified XynNF was up to 3,081.05 IU/mg with a 14.55-fold purification. The activity of XynNF was stimulated by Ca 2+ , Ba 2+ , DTT, and β-mercaptoethanol, but was inhibited by Fe 3+ , Zn 2+ , Fe 2+ , Cu 2+ , SDS, and EDTA. The purified XynNF displayed a greater affinity for oat spelt xylan with the maximal enzymatic activity at 60℃ and pH 6.0. XynNF, which was shown to be cellulose-free, with high stability at high temperature (70℃-80℃) and low pH range (pH 4.0-7.0), is potentially valuable for various industrial applications. The enzyme hydrolyzed oat spelt xylan to yield mainly xylooligosaccharides (95.8%) of 2-4 degree of polymerization (DP2-4). Moreover, the majority of the xylooligosacharides (DP2-4) products was xylobiose (61.5%). The thermostable xylanase (XynNF) thus seems potentially usefull in the production of xylooligosaccharides.
Endo-1,4-β- D -xylanase (E.C. 3.2.1.8) is an important enzyme for the degradation of the major hemicellulosic polysaccharide of lignocellulosic materials, since they hydrolyze xylopyranosyl linkages of β-1,4-xylan  . As the key xylan-degrading enzyme, xylanases have attracted considerable attention because of their widespread application in various industrial processes such as pulp bleaching, animal feeding, baking and brewing, wastetreating, bioenergy converting, textiles, and food industry [1 , 12] . Recently, Paenibacillus species is frequently isolated and identified from various sources for their ability to hydrolyze lignocellulosic materials. Many strains of Paenibacillus species, like P. campinasensis G1-1  producing a thermostable xylanase, Paenibacillus terrae HPL-003 producing a new bimodular xylanase  , and alkalophilic Paenibacillus sp. 12-11  producing an alkaline xylanase, showed various application potential.
Xylan, composed of a linear backbone of 1,4-β-linked D -xylose units, is the major constituent of hemicellulose, which is the second most abundant component of plant biomass  . It can be hydrolyzed to xylose by the synergistic effect of endoxylanase, exoxylanase, and β-xylosidase. When it was hydrolyzed by only endoxylanase, the major product was xylooligosaccharides (XOS). XOS are newly developed functional oligosaccharides that exhibit excellent prebiotic effect and health benefits, such as the stimulation of human intestinal Bifidobacteria and Lactobacillus growth [5 , 6 , 13] . Currently, XOS are produced mainly by enzymatic hydrolysis owing to high specificity, negligible substrate loss, and side product generation [22 , 29] . However, the xylanases to be used for XOS production should preferably be free of or have very little exoxylanase and β-xylosidase activities stable at high temperature to withstand xylan extraction conditions and be available at low cost [3 , 13] . Therefore, thermophilic endoxyalnases are best suited for XOS production.
In our previous report, a novel strain, Paenibacillus sp. NF1, producing high levels of extracellular thermostable xylanase was isolated from cow dung compost in China  . In order to characterize the xylanase from Paenibacillus sp. NF1, it was purified to homogeneity from culture supernatants by three kinds of chromatography. The attractive attributes and special hydrolysis products of this xylanase suggest that it is potentially valuable for various industrial applications, especially for xylooligosaccharides production.
Paenibacillus sp. NF1, which was isolated, identified, and cultivated for xylanase production as described earlier  , was preserved in our laboratory. Oat spelt xylan, birchwood xylan, carboxymethyl cellulose (CMC), Avicel, xylose, xylobiose, xylotriose, xylotetraose, sodium dodecyl sulfate (SDS), β-mercaptoethanol, bovine serum albumin (BSA), and 3,5-dinitrosalicylic acid (DNS) were purchased from Sigma Chemical Co. (St. Louis, MO, USA). Octyl-Sepharose, Sephadex G75, and Q-Sepharose were purchased from GE Healthcare Life Sciences (Pittsburgh, PA, USA). All other chemicals were of analytical reagent grade purity and obtained from commercial sources.
For xylanase production, Paenibacillus sp. NF1 was grown in optimized medium  containing corncob 20 g/l, beef extract 28.2 g/l, K 2 HPO 4 5 g/l, MgSO 4 0.5 g/l, and NaCl 7.1 g/l, at 28℃ with shaking at 160 rpm. Culture samples were collected at 6 h intervals over the period of 96 h cultivation. The initial pH of the medium was 6.9 and the inoculum size was 2%.
The culture supernatants of Paenibacillus sp. NF1 were collected by centrifugation (8,000 rpm for 10 min at 4℃). The supernatants collected after centrifugation were salted out with ammonium sulfate at 70% saturation. After that, the precipitates were dissolved in sodium phosphate buffer (20 mM, pH 6.0), and solid ammonium sulfate was added to adjust to the final saturation of 40%. The samples were loaded onto an Octyl-Sepharose FF column (2.6 × 20 cm) pre-equilibrated with sodium phosphate buffer (20 mM, pH 6.0) containing 40% saturation of ammonium sulfate. The target protein was eluted with a linear gradient (40%-0% saturation) of ammonium sulfate in sodium phosphate buffer (20 mM, pH 6.0). The active fractions were loaded onto a Sephadex G75 column (1.6 × 60 cm) equilibrated with sodium phosphate buffer (20 mM, pH 8.0). The xylanase active fractions were collected for further purification by a Q-Sepharose HP column (2.6 × 20 cm) using linear gradient elution from 0-1 M NaCl in sodium phosphate buffer (20 mM, pH 8.0). Finally, the purified xylanase was desalted by dialysis against deionized water and concentrated by freeze-drying. The protein concentration of the samples at each step of chromatography was determined spectrophotometrically at 280 nm. The protein concentration of the pooled enzyme solution from each purification step was determined according to the Bradford method  using BSA as the standard.
The purified and concentrated xylanase preparations were analyzed by SDS-PAGE using a 12% polyacrylamide gel containing 0.1% (w/v) oat spelt xylan. After electrophoresis, the gel was divided and the protein bands were visualized by staining with Coomassie Brilliant Blue G250 (Sigma) or detected for xylanase activity [9 , 11] . For zymogram analysis, the gel was treated with 25% 2-propanol and incubated at 60℃ for 30 min in 20 mM sodium phosphate buffer (pH 6.0). After incubation, the gel was subsequently incubated under agitation at room temperature in Congo red solution (1 mg/ml) for 10 min, washed with 1 M NaCl, and fixed with 5% (v/v) acetic acid  . Clear areas in the zymogram indicated enzyme activity. Molecular weight standards from Fermentas were used as molecular mass markers.
The activity of xylanase was measured by determining the amount of reducing sugars liberated from 1% oat spelt xylan using 3,5-dinitrosalicylic acid at 60℃ and pH 6.0  . The method was described previously by Zheng et al .  . The amount of enzyme that liberated 1 μmol of reducing sugars per minute was defined as one unit (IU) of xylanase activity.
The optimum temperature of the xylanase was measured by incubating the reaction mixtures at different temperatures (40-80℃) and pH 6.0 for 10 min. The relative enzymatic activity was calculated as a percentage of the maximal activity. Its thermal stability was determined by incubating the purified xylanase in sodium phosphate buffer (20 mM, pH 6.0) at various temperatures (40-80℃) for 180 min. The residual enzyme activity was calculated as a percentage of the starting activity. The optimum pH of xylanase activity was measured at 60℃ using acetic acid sodium buffer (pH 3.0-5.0), sodium phosphate (pH 6.0-7.0), Tris-HCl (pH 8.0-9.0), and glycine-NaOH (pH10.0), respectively, at the same concentration of 20 mM. The relative enzymatic activity was calculated as a percentage of the maximal activity. To assess its pH stability, the purified xylanase was preincubated in buffers at various pH values (pH 3.0-10.0) at 60℃ for 180 min and the residual activities were determined at 30 min intervals.
The effects of various metal ions (KCl, CaCl 2 , BaCl 2 , MgCl 2 , MnCl 2 , FeCl 2 , FeCl 3 , ZnCl 2 , and CuSO 4 ), metal chelators (EDTA) and surfactants (DTT, β-mercaptoethanol, and SDS) on the purified xylanase activity were evaluated by including it in the reaction mixtures at the concentration of 1 mM and 10 mM. Enzyme solutions were incubated at 60℃ for 60 min before the residual activity was measured. The activity of the enzyme assayed under the same condition without additives was defined as 100%.
The specificities and kinetic constants (K m and V max ) of xylanase were determined following the method of Zheng et al .  . For specificities determination, the activity of the purified xylanase against oat spelt xylan, birchwood xylan, rice hull xylan, bran xylan, CMC, and Avicel at concentrations of 1% (w/v) at 60℃ and pH 6.0 were assayed. The enzyme preparations were incubated with oat spelt xylan and birchwood xylan at concentrations between 0.1% (w/v) and 1% (w/v) to estimate the kinetic parameters (K m and V max ) of the purified xylanase using a Lineweaver-Burk double reciprocal plot.
One hundred fifty micrograms of oat spelt xylan in 1.5 ml sodium phosphate buffer (pH 6.0) was treated with 30 IU of the diluted purified xylanase at 60℃ for 10 min, 1 h, and 2 h, respectively. The xylanase hydrolysates were analyzed by an HPLC (Agilent). HPLC analysis was done by using a chromatographic column (Shodex SUGAR KS-801, 8.0 × 300 mm) at 65℃ with water as the mobile phase at 0.6 ml/min.
When Paenibacillus sp. NF1 was cultured by the submerged method, the xylanase was secreted to the culture liquid. The production of extracellular xylanases by Paenibacillus sp. NF1 was investigated during 96 h of cultivation in the optimized production medium (detailed in Materials and Methods). As shown in Fig. 1 , exponential growth of Paenibacillus sp. NF1 was observed until 42 h, and then the stationary phase was ended after 30 h. Moreover, Paenibacillus sp. NF1 secreted extracellular xylanases at a low rate in the exponential phase and achieved the maximal xylanase production of up to 165.2 IU/ml at the end of the stationary phase (72 h, Fig. 1 ). After the stationary phase (72 h), the xylanase activity was gradully decreased because of hydrolysis by autologous protease in the decline phase of strain NF1. This course of xylanase degradation was also observed from Fomitopsis pinicola KMJ812  and Paenibacillus campinasensis G1-1  reported previously. Paenibacillus sp. NF1 producing relatively high levels of xylanases compared with those reported previously [21 , 24 , 25] could be an efficient and economical microorganism with potential applications in industrial production.
Growth and extracellular xylanase production of Paenibacillus sp. NF1.	The culture growth was monitored by measuring the optical density at 600 nm with a 6 h interval, and the xylanase activity was also assayed using the DNS method. Data are presented as means ± SD (n = 3).
Under the optimized culture conditions, the specific activity of xylanase produced by Paenibacillus sp. NF1 reached to 211.79 IU/mg ( Table 1 ). The xylanase was purified to electrophoretic homogeneity by the steps listed in Table 1 . The specific activity of the purified xylanase was 3,081.05 IU/mg with a 14.55-fold purification, and the final yield for the enzyme was 10.63% ( Table 1 ). As a single band on SDS-PAGE with an apparent molecular mass of about 37 kDa, the purified xylanase from culture supernatants was designated as XynNF ( Fig. 2 , lane 3), whereas zymogram analysis of the purified XynNF exhibiting a clear activity band on the corresponding zone further confirmed the presence of active xylanase ( Fig. 2 , lane 4). It also indicates that XynNF from Paenibacillus sp. NF1 was a monomeric protein comparable to those previously reported for other xylanases [16 , 21 , 23] .
SDS-PAGE and zymogram analysis of the purified xylanase from Paenibacillus sp. NF1.	The contents of each lane are as follows: Lane M: molecular weight of marker standard; Lane 1: crude extracellular xylanase from Paenibacillus sp. NF1; Lane 2: XynNF purified by hydrophobic-interaction chromatography; Lane 3: purified XynNF; Lane 4: zymogram analysis of the purified XynNF.
Purification of xylanase (XynNF) fromPaenibacillussp. NF1.
Purification of xylanase (XynNF) from Paenibacillus sp. NF1.
The optimal reaction temperature of XynNF was 60℃, which is higher than that of Paenibacillus sp. 12-11 (55℃)  , and the enzyme retained 46.88% of its maximum activity at 70℃ ( Fig. 3 A). The thermal stability of XynNF was evaluated by incubation at temperatures from 40℃ to 80℃ for 180 min. The enzymatic activity retained at least 71.07% of the original activity after incubation at 40℃ to 60℃ for 180 min, and still retained about 70.65% and 42.66% of the original activity after incubation at 70℃ and 80℃ for 60 min, respectively ( Fig. 3 B). This thermal stability is better than earlier reports on most of the bacterial xylanases [1 , 14 , 19 , 26] . The purified XynNF showed the maximum activity at pH 6.0, which is lower than that of XynG1-1 (7.5) from P. campinasensis G1-1  and retained 59.78% of its maximum activity at pH 3.0 ( Fig. 4 A). It was stable between pH 4.0 and 7.0 for 180 min, retaining at least 59.11% of its activity at pH 6.0 ( Fig. 4 B), manifesting much greater pH stability at the condition of lower pH than those of most bacterial xylanases reviewed [1 , 19 , 26] . Its stability at high temperature (70℃-80℃) and activity at the condition of lower pH (pH 4.0-7.0) ( Figs. 3 and 4 ) make XynNF valuable for various industrial applications, such as animal feeding, bioenergy converting, and food industry.
Effects of temperature on the activity (A) and stability (B) of the purified XynNF.	(A) Relative activities at different temperatures; the maximum activity observed at 60℃ was taken as 100%. (B) Residual activities after incubation for various times at 40℃ to 80℃, pH 6.0. The original activity without incubation was taken as 100%. Data are presented as means ± SD (n = 3).
Effects of pH on the activity (A) and stability (B) of the purified XynNF.	(A) Relative activities at different pH values; the maximum activity observed at pH 6.0 was taken as 100%. (B) Residual activities after incubation for various times at pH 3.0 to 10.0, 60℃. The original activity without incubation was taken as 100%. Data are presented as means ± SD (n = 3).
Addition of 1 mM or 10 mM of K + , Mg 2+ , and Mn 2+ had no significant effect on the purified XynNF ( Table 2 ). However, the purified XynNF was activated by Ca 2+ and Ba 2+ and was inhibited by certain metal ions in the following order: Fe 3+ > Zn 2+ > Fe 2+ > Cu 2+ ( Table 2 ). The reducing agents, DTT and β-mercaptoethanol, stimulated the activity of XynNF ( Table 2 ). The strong inhibition by SDS and EDTA ( Table 2 ) indicates that hydrophobic interactions may be important in maintaining the structure of XynNF and certain metal ions were required for its activity.
Effects of metal ions and other additives on the activity of the purified XynNF.
aThe activity of the enzymes assayed under the optimum condition in the absence of additives was defined as 100%. Data are presented as means ± SD (n = 3).
Specificity studies indicate that XynNF could hydrolyze all the tested xylans, but did not act on CMC and Avicel. The purified XynNF exhibited the highest xylanase activity when oat spelt xylan or birchwood xylan was used as the substrate ( Table 3 ), with relatively lower activities being measured for rice hull xylan (82.23%) and bran xylan (79.86%). In addition, the purified XynNF showed K m values of 5.64 and 6.32 mg/ml and V max values of 3,364.57 and 3,216.44 μ mol/min/mg of protein for oat spelt xylan and birchwood xylan, respectively. The values of K m for these two substrates indicated that XynNF had greater affinity for oat spelt xylans. Strong specificity toward birchwood xylan and oat spelt xylan was also verified for xylanases from P. campinasensis BL11  , T. clypeatus  , and P. sclerotiorum  .
Substrate specificity and kinetic parameters of the purified XynNF.
aRelative activity (%): the maximum specific activity was taken as 100%.	bND: not detectable. Data are presented as means ± SD (n = 3).
When oat spelt xylan was incubated with the purified XynNF for 2 h at 60℃ and pH 6.0, the major hydrolysis products were xylobiose, identified by HPLC ( Table 4 and Fig. 5 ). After a 10 min reaction time, about half of the larger polysaccharides (≥xylopentaose) was hydrolyzed to xylobiose, xylotriose, and xylotetraose, but no xylose was liberated ( Table 4 ). Xylobiose and xylotriose contents increased steadily during further incubation for 1 h; however, xylotetraose and xylose were not increased ( Table 4 ). The amount of xylotetraose remained almost constant from 10 min to 2 h reaction and there were no higher xylooligosaccharides (≥xylopentaose) in the hydrolysis products until the end of the hydrolysis at the reaction time of 2 h ( Table 4 , Fig. 5 D). It indicates that XynNF was more efficient in conversion than S. thermophile xylanase  , which took 8 h for complete hydrolysis of oat spelt xylan. By HPLC analysis of xylanase hydrolysates against oat spelt xylan, xylotetraose and higher xylooligosaccharides were found to be efficiently hydrolyzed mainly to xylobiose, a small part of xylotriose appeared to be further hydrolyzed to xylobiose and xylose until 2 h, while xylotetraose was mainly hydrolyzed to xylobiose, but no xylobiose were hydrolyzed to xylose ( Table 4 and Fig. 5 ). Therefore, XynNF was confirmed to be an endoxylanase rather than a β-xylosidase that hydrolyzes xylobiose to xylose. When the reaction time was increased from 10 min to 2 h, the xylooligosacharides (DP2-4) content finally increased to 95.8% ( Table 4 ) and xylobiose was the majority of the xylooligosacharides (DP2-4) products ( Fig. 5 ). With the time course of hydrolysis, the amount of xylobiose increased further reaching to 61.5% in 2 h ( Table 4 ). The high catalytic efficiency and enrichment effect of xylobiose makes XynNF a highly potential enzyme in xylooligosaccharides production.
Chromatograms from HPLC analysis of the oat spelt xylan hydrolysates by the purified xylanase (XynNF).	Enzyme-substrate mixtures containing 1.5 ml of 1% (w/v) oat spelt xylan and 30 IU of the diluted purified xylanase were incubated at 60℃ and pH 6.0 for 0 min (A), 10 min (B), 1 h (B), and 2 h (D), respectively. The oligomeric state (DP2-4) of each peak was determined by comparing it with the retention time of the xylooligomer standard marker.
HPLC analysis of the products liberated by the action of the purified xylanase (XynNF) on oat spelt xylan.
In conclusion, the endoxylanase (XynNF) of Paenibacillus sp. NF1 was purified to homogeneity by multistep chromatographies. Its stability at high temperature (70℃-80℃) and low pH range (pH 4.0-7.0) makes it a suitable biocatalyst for various industrial applications. In particular, its application in oat spelt xylan hydrolysis, showing 95.8% xylooligosaccharides (DP 2-4) products, makes it a promising candidate for xylooligosaccharides production.
Financial support from the National Natural Science Fund (Grant 21176247), the National High Technology Research and Development Program of China (Grant 2013AA102106), and China Postdoctoral Science Fund (Grant 2013M540076) are gratefully acknowledged.
 HC Zheng , MZ Sun , LC Meng , HS Pei , XQ Zhang , Z Yan , WH Zeng , JS Zhang , JR Hu , FP Lu , and JS Sun , "Purification and Characterization of a Thermostable Xylanase from Paenibacillus sp. NF1 and its Application in Xylooligosaccharides Production", Journal of Microbiology and Biotechnology, vol. 4, no. 4, Apr 2014.


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MedTech Deals Worth $15.8 Billion in Q2
By MedTech Intelligence Staff
Overall activity in deals jumped 11% in North America.
With 253 deals occurring during this year's second quarter, the medical device industry experienced an 11% increase in deal activity versus its four-quarter average, according to a recent report released by analyst firm GlobalData. Venture financing accounted for nearly 75% of the deals (189 transactions), followed by mergers and acquisitions at 20% and private equity deals at 5% (13 deals). M&A led the pack when looking at deal value, which was estimated at about $13.6 billion. Venture capital financing was at $2 billion, followed by private equity at $211 million.
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