text:
Can 'Omicron' Covid Variant Be Detected Using PCR Testing? WHO Says...
Omicron Covid Variant: The WHO has said studies into various aspects of the new variant would take several weeks to reach conclusions.
While PCR tests can detect infection with Omicron, studies are looking to whether the Covid-19 variant of concern has any impact on other test types, the WHO said Sunday.
"The widely-used PCR tests continue to detect infection, including infection with Omicron, as we have seen with other variants," the World Health Organization said in an update on what is known so far about the new variant.
"Studies are ongoing to determine whether there is any impact on other types of tests, including rapid antigen detection tests."
The WHO on Friday declared Omicron, first detected earlier this month in southern Africa, to be a variant of concern.
The classification put Omicron into the most troubling category of Covid-19 variants, along with the globally dominant Delta, and its weaker rivals Alpha, Beta and Gamma.
Omicron spread across the globe on Sunday, shutting borders and renewing curbs as the EU chief said governments faced a "race against time" to understand the strain.
The variant has cast doubt on global efforts to battle the pandemic due to fears that it is highly infectious, forcing countries to reimpose measures many had hoped were a thing of the past.
In its update, the WHO said it was "not yet clear" whether Omicron spreads more easily from person to person, or whether infection with the variant causes more severe disease compared to other strains.
"There is currently no information to suggest that symptoms associated with Omicron are different from those from other variants," the UN health agency said.
While preliminary evidence suggests there may be an increased risk of people who previously had Covid being reinfected with Omicron, information is currently limited.
The WHO said it was working to understand the potential impact of the variant on existing counter-measures, including vaccines.
As for treatments, the organisation said corticosteroids and IL6 receptor blockers would still be effective for managing patients with severe Covid-19 -- while other treatments would be assessed to see if they are still as effective against Omicron.
The WHO has said studies into various aspects of the new variant would take several weeks to reach conclusions.
"WHO is coordinating with a large number of researchers around the world to better understand Omicron," it said.
"More information will emerge in the coming days and weeks."
#Vaccines #COVID-19 #Covid


text:
Q: Creating directory in C, Windows, MinGW (CodeBlocks) code does not create directories I need to create a simple directory tree using C on Windows. However, my code does not create directories, just prints them out, and thats it:
#include <stdio.h>
#include <stdlib.h>
#include <string.h>
#include <windows.h>

void createDirTree(char *path)
{
    char *tmp = NULL, *start = NULL, *end = NULL, *slash = NULL;

    tmp = malloc(sizeof(char) * (strlen(path) + 1));
    strcpy(tmp, path);

    start = tmp;
    end = start + strlen(path);

    while (start < end)
    {
        char *slash = strchr(start, '/');
        if (strcmp(start, ".") != 0)
        {
            CreateDirectory(tmp, NULL);
            printf("going to make %s\n", tmp);
        }
        if (!slash)
        {
            break;
        }
        *slash = '/';
        start = slash + 1;
    }

    free(tmp);
}

int main()
{
    char path1[] = "./mydir/dir1/dir2/";
    char path2[] = "./mydir/dir1/dir2/dir45/";
    createDirTree(path1);
    createDirTree(path2);
    return 0;
}

A: I don't get the output one would expect:
createDirTree ("root/test/test2");

produces
going to make root/test/test2
going to make root/test/test2
going to make root/test/test2

With this additional line right after the strchr:
while (start < end)
{
    slash = strchr(start, '/');
    if (slash) *slash = 0;  /* new line */

I get the following, more logical, output:
going to make root
going to make root/test
going to make root/test/test2

When you are following the advice on error checks for CreateDirectory: I think you can safely ignore and continue when you get an ERROR_ALREADY_EXISTS.

A: One problem is that all parts of the path will be created (if created at all) in the same directory. Once you have created the root directory you do not append the next part of the path, and you don't go into the new directory, which means that a path such as "some\\path\\with\\folders" will not create this hierarchy:

\
`-- some
    `-- path
        `-- with
            `-- folders

Instead it will create

\
|-- some
|-- path
|-- with
`-- folders

However, if you don't even get this tree, you should check what CreateDirectory returns. If it fails you need to check for that, and check what the error is. If you perform an operation that can fail, you should always check for failure.

redpajama_set_name: RedPajamaStackExchange


text:
#region license
// Copyright (c) 2007-2010 Mauricio Scheffer
//
// Licensed under the Apache License, Version 2.0 (the "License");
// you may not use this file except in compliance with the License.
// You may obtain a copy of the License at
//
//      http://www.apache.org/licenses/LICENSE-2.0
//
// Unless required by applicable law or agreed to in writing, software
// distributed under the License is distributed on an "AS IS" BASIS,
// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
// See the License for the specific language governing permissions and
// limitations under the License.
#endregion

using System.Collections.Generic;
using System.Threading.Tasks;
using System.Xml.Linq;
using Newtonsoft.Json;
using SolrNetLight.Commands;
using SolrNetLight.Commands.Parameters;

namespace SolrNetLight.Impl
{
    /// <summary>
    /// Implements the basic Solr operations
    /// </summary>
    /// <typeparam name="T">Document type</typeparam>
    public class SolrBasicServer<T> : ISolrBasicOperations<T>
    {
        private readonly ISolrConnection connection;
        private readonly ISolrQueryExecuter<T> queryExecuter;
        //private readonly ISolrHeaderResponseParser headerParser;
        private readonly ISolrQuerySerializer querySerializer;

        public SolrBasicServer(ISolrConnection connection, ISolrQueryExecuter<T> queryExecuter, ISolrQuerySerializer querySerializer, ISolrExtractResponseParser extractResponseParser = null)
        {
            this.connection = connection;
            //this.extractResponseParser = extractResponseParser;
            this.queryExecuter = queryExecuter;
            //this.documentSerializer = documentSerializer;
            //this.schemaParser = schemaParser;
            //this.headerParser = headerParser;
            this.querySerializer = querySerializer;
            //this.dihStatusParser = dihStatusParser;
        }

        public async Task<ResponseHeader> Commit(CommitOptions options)
        {
            options = options ?? new CommitOptions();
            var cmd = new CommitCommand
            {
                WaitFlush = options.WaitFlush,
                WaitSearcher = options.WaitSearcher,
                ExpungeDeletes = options.ExpungeDeletes,
                MaxSegments = options.MaxSegments,
            };
            return await SendAndParseHeader(cmd);
        }

        public async Task<ResponseHeader> Rollback()
        {
            return await SendAndParseHeader(new RollbackCommand());
        }

        public async Task<ResponseHeader> AddWithBoost(IEnumerable<KeyValuePair<T, double?>> docs, AddParameters parameters)
        {
            var cmd = new AddCommand<T>(docs, parameters);
            return await SendAndParseHeader(cmd);
        }

        public async Task<SolrQueryResults<T>> Query(ISolrQuery query, QueryOptions options)
        {
            return await queryExecuter.Execute(query, options);
        }

        public async Task<string> Send(ISolrCommand cmd)
        {
            return await cmd.Execute(connection);
        }

        public async Task<ResponseHeader> SendAndParseHeader(ISolrCommand cmd)
        {
            var jsonResponse = await Send(cmd);

            return JsonConvert.DeserializeObject<ResponseHeader>(jsonResponse);

        }

    }
}

redpajama_set_name: RedPajamaGithub


text:
Feb. 3, 2014, 10:43 a.m.
Snaps from last night: How The Washington Post tried a Super Bowl experiment on Snapchat
"Experimenting live — just doing it — is the best way to learn," a Post editor says.
By Cory Haik @coryhaik Feb. 3, 2014, 10:43 a.m.
Some of the best experiments I've worked on in digital news are the ones done in the moment, unplanned. That's very much how we came up with the idea to live-Snapchat the Super Bowl's ads last night.
Like many news sites, we'd posted all the night's ads ahead of the game (the ones that were not embargoed, at least), and those had done well for us traffic-wise. And we had a good plan in place to cover both the game and the ads with our liveblog and other tools. We are all set! Then we noticed that Facebook was asking for celebs to "live-Facebook" their game experiences and that the hashtags were already humming on Twitter. So the Snapchat idea popped up.
We'd launched a presence on Snapchat a few weeks ago for our politics coverage (you can follow it by adding "postpolitics" from your account). But we hadn't really done anything live. Here's some of what we learned:
Live is hard. One of the powerful elements of Snapchat is its in-the-moment-ness. When you start using apps like Latersnap and producing out snaps, it becomes a different product. That's cool, and we're doing that too, but again, live is different and much harder. You really get one chance to snap in the moment. If you've got a good producer on live Twitter, get them running your snaps. Or better yet, your (faster) field photographer.
Snapchat's Stories function is perfect for unfolding events, but those seconds add up. In the end, we had 133 seconds of snaps, representing nearly all of the Super Bowl commercials. That's a great string in the order we saw it and snapped, but it's also a long time for the user to sit through the end slideshow. We did a still image for almost each commercial and had it display for 2 seconds. Maybe that should have been just one?
Fewer words: also hard, but direct. You have fewer than 30 characters using the native text function on Snapchat — that's about a quarter of a tweet. You can effectively write a really short headline and hit send/save. No real room to overthink here. For example, on the Maserati ad featuring Quvenzhané Wallis from Beasts of the Southern Wild we used the text "Beasts of the Maserati."
You can't reorder, so think (fast) before sending. When you are filing to Stories live, all your snaps are ordered chronologically. The only thing you can do to edit that order is to delete a snap. There's no way to go back in. Again, Snapchat is all about being truly in the moment. This may be closer to live TV than anything a digital journalist has seen yet.
Even though the world can see it, it feels personal, especially when they snap you back! You are producing something from the palm of your hand that is exclusively going to someone else's. If you have your settings configured for it, anyone can add your account and see what you're doing. And then anyone can send you a snap — which three people did. (We didn't really promote this experiment, so we were happy with the viewership we got.) That was fun for us: direct engagement in the moment from someone else experiencing the same thing we were. We think this engagement piece has a lot of unseen potential.
Snapping live TV is a little weird. The images were not beautiful. The shots were sideways. It's hard to get a clear picture that's not blurry. There's something about this aesthetic that makes it very…Snapchat?!
Going forward, we think we'll use this more for IRL events. Experimenting live — just doing it — is the best way to learn. You can see our snaps from last night by adding 'coryinbeta' from your Snapchat account.
Cory Haik is executive producer and senior editor for digital news at The Washington Post.
POSTED Feb. 3, 2014, 10:43 a.m.
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Cory Haik
livetweeting
Show tagsHide tags
Haik, Cory. "Snaps from last night: How The Washington Post tried a Super Bowl experiment on Snapchat." Nieman Journalism Lab. Nieman Foundation for Journalism at Harvard, 3 Feb. 2014. Web. 18 Jan. 2020.
Haik, C. (2014, Feb. 3). Snaps from last night: How The Washington Post tried a Super Bowl experiment on Snapchat. Nieman Journalism Lab. Retrieved January 18, 2020, from https://www.niemanlab.org/2014/02/snaps-from-last-night-how-the-washington-post-tried-a-super-bowl-experiment-on-snapchat/
Haik, Cory. "Snaps from last night: How The Washington Post tried a Super Bowl experiment on Snapchat." Nieman Journalism Lab. Last modified February 3, 2014. Accessed January 18, 2020. https://www.niemanlab.org/2014/02/snaps-from-last-night-how-the-washington-post-tried-a-super-bowl-experiment-on-snapchat/.
| url = https://www.niemanlab.org/2014/02/snaps-from-last-night-how-the-washington-post-tried-a-super-bowl-experiment-on-snapchat/
| title = Snaps from last night: How The Washington Post tried a Super Bowl experiment on Snapchat
| last = Haik
| first = Cory
| date = 3 February 2014
| ref = {{harvid|Haik|2014}}
Join the 50,000 who get the freshest future-of-journalism news in our daily email.
Not all protests get treated equally. Stories about women's marches and anti-Trump protests give more voice to the protesters than those about Black Lives Matter and other anti-racism protests.
Plus: Emphasizing a publisher's name on social doesn't seem to impact readers' misinfo radar much one way or the other.
MediaReview wants to turn the mishmash vocabulary around manipulated photos and video into something structured.

redpajama_set_name: RedPajamaCommonCrawl


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January 30, 2019 / J.D.
We use Jason Cordova's Labyrinth Move (of Gauntlet fame; link incoming) to construct a session where our heroes explore the magical portal they figured out in the last chapter. They travel across great distances, but push through to get closer to the heart of the Dimansion... and to Ypsilanti's most private space.


text:
Caribbean Court of Justice allows Guyanese architect firm to recover GY$15 million
Posted by: Denis Chabrol in Business, Courts, News May 5, 2018	0
Guyana's New Building Society Ltd was ordered by the Caribbean Court of Justice (CCJ) to pay Rodrigues Architects Ltd for services provided in relation to the construction of New Building Society Ltd's head office.
The CCJ says it discharged a stay of execution that had been granted in a lower court, enabling the company to recover the balance of monies due.
In 2015, Mr Justice Persaud ordered the building society to pay Rodrigues Architects Ltd the sum of GY$15,897,625, plus 6% interest per annum from 27th November 2008 to 29th September 2015 and thereafter at the rate of 4% per annum until fully paid, and GY$100,000 for costs.
He further ordered that there be a stay of execution for a period of six months from the date of the order. No judgment, however, has yet been delivered to provide reasons for the order.
New Building Society Ltd applied for a stay of execution of the judgment pending the appeal. Justice of Appeal Roy granted the stay until the determination of the appeal but ordered that the judgment sum due to Rodrigues Architects Ltd be deposited with the Registrar to be put in an interest-bearing account to await the outcome of the appeal. Rodrigues Architects Ltd failed to get Guyana's Court of Appeal to overturn Mr Justice Roy's decision. The company then applied to the CCJ to discharge the stay of execution and obtain the deposited sum.
The Court, after reviewing the affidavit evidence, found that Mr Justice Roy had erred in making his orders, and the Court of Appeal had erred in reviewing those orders and letting them stand. No stay should have been granted because it had not been shown that there was a good prospect of the appeal succeeding nor that there was no reasonable probability that the company would be able to repay the money received from the building society if the
latter's appeal succeeded.
Further to that, Mr Rodrigues, a director of the company who has been in business for over 35 years, had been prepared to guarantee that he would personally repay the judgment sum paid to Rodrigues Architects Ltd if the society's appeal succeeded.
Previous: Region One residents get birth certificates
Next: British colonial sedition law crushed free expression by Blacks; has no place in independent Guyana


If a configuration needs to be restored to a new setup, but it is cumbersome to go through all the trouble of setting up a system and restoring via the WebGUI, there are much easier ways.
These methods are significantly easier than reconfiguring the LAN and restoring via the network. The firewall will start up using the restored configuration immediately without needing intermediate steps.
The installer pfSense version 2.4 has a Recover config.xml option which reads a configuration from an existing installation being overwritten. This makes it useful for upgrades, filesystem changes, or any other situation where a reinstallation is required on the same hardware.
Before starting, take a backup of the configuration if possible, in case this procedure does not work as expected.
pfSense has, as part of the installation routine, a step that checks for an existing configuration on a USB drive and, if one is found, copies it to the target drive.
For this feature to work correctly, the USB drive must contain a partition table and it must not be formatted as a raw device.
If the USB drive is removed too early, it may still be mounted and the system will panic!
This procedure is nearly identical to the method in the previous section, but the USB disk containing the configuration does not need to be present during the installation.
For this process, the configuration file must be placed on the USB drive in /config.xml or /config/config.xml.
After the installation completes, insert the USB drive containing the configuration before the firewall boots and the firewall will read it in from there.
If it is the first boot post-installation, then this process also triggers reinstallation of packages listed in the restored configuration.


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text:
//-----------------------------------NOTICE----------------------------------//
// Some of this file is automatically filled in by a Python script.  Only    //
// add custom code in the designated areas or it will be overwritten during  //
// the next update.                                                          //
//-----------------------------------NOTICE----------------------------------//

#ifndef _NIFLOATEXTRADATA_H_
#define _NIFLOATEXTRADATA_H_

//--BEGIN FILE HEAD CUSTOM CODE--//
//--END CUSTOM CODE--//

#include "NiExtraData.h"
namespace Niflib {

class NiFloatExtraData;
typedef Ref<NiFloatExtraData> NiFloatExtraDataRef;

/*! Float extra data. */
class NiFloatExtraData : public NiExtraData {
public:
	/*! Constructor */
	NIFLIB_API NiFloatExtraData();

	/*! Destructor */
	NIFLIB_API virtual ~NiFloatExtraData();

	/*!
	 * A constant value which uniquly identifies objects of this type.
	 */
	NIFLIB_API static const Type TYPE;

	/*!
	 * A factory function used during file reading to create an instance of this type of object.
	 * \return A pointer to a newly allocated instance of this type of object.
	 */
	NIFLIB_API static NiObject * Create();

	/*!
	 * Summarizes the information contained in this object in English.
	 * \param[in] verbose Determines whether or not detailed information about large areas of data will be printed out.
	 * \return A string containing a summary of the information within the object in English.  This is the function that Niflyze calls to generate its analysis, so the output is the same.
	 */
	NIFLIB_API virtual string asString( bool verbose = false ) const;

	/*!
	 * Used to determine the type of a particular instance of this object.
	 * \return The type constant for the actual type of the object.
	 */
	NIFLIB_API virtual const Type & GetType() const;

	/***Begin Example Naive Implementation****

	// The float data.
	// \return The current value.
	float GetFloatData() const;

	// The float data.
	// \param[in] value The new value.
	void SetFloatData( float value );

	****End Example Naive Implementation***/

	//--BEGIN MISC CUSTOM CODE--//

	/*!
	 * Retrieves the floating point value stored in this object.
	 * \return The floating point value stored in this object.
	 */
	NIFLIB_API float GetData() const;

	/*!
	 * Sets the floating point value stored in this object.
	 * \param[in] n The new floating point value to store in this object.
	 */
	NIFLIB_API void SetData( float n );

	//--END CUSTOM CODE--//
protected:
	/*! The float data. */
	float floatData;
public:
	/*! NIFLIB_HIDDEN function.  For internal use only. */
	NIFLIB_HIDDEN virtual void Read( istream& in, list<unsigned int> & link_stack, const NifInfo & info );
	/*! NIFLIB_HIDDEN function.  For internal use only. */
	NIFLIB_HIDDEN virtual void Write( ostream& out, const map<NiObjectRef,unsigned int> & link_map, list<NiObject *> & missing_link_stack, const NifInfo & info ) const;
	/*! NIFLIB_HIDDEN function.  For internal use only. */
	NIFLIB_HIDDEN virtual void FixLinks( const map<unsigned int,NiObjectRef> & objects, list<unsigned int> & link_stack, list<NiObjectRef> & missing_link_stack, const NifInfo & info );
	/*! NIFLIB_HIDDEN function.  For internal use only. */
	NIFLIB_HIDDEN virtual list<NiObjectRef> GetRefs() const;
	/*! NIFLIB_HIDDEN function.  For internal use only. */
	NIFLIB_HIDDEN virtual list<NiObject *> GetPtrs() const;
};

//--BEGIN FILE FOOT CUSTOM CODE--//
//--END CUSTOM CODE--//

} //End Niflib namespace
#endif


text:
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Shop Native Plants by State
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Photo by: Areti Clark
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Become a critical force for change by taking a journey with us. People and wildlife are sharing space with what was once critical habitat for wildlife. Now more than ever, there is a pressing need to help find a balance where people and wildlife can coexist and turn the tide of declines. Together, we can do our part to create change.
Metropolitan populations combined, equal an area half the size of the 48 states, which is also where two thirds of wildlife species reside.
Your impact reaches far beyond your own garden. If you have a lawn, consider making it smaller with wildflowers, shrubs, trees and other native plants, you'll be creating habitat for declining wildlife, but also helping to reduce urban heat islands and manage storm water runoff. And unlike lawns, wildflowers don't rely on toxic chemicals to look amazing.
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The Right Plants for the Right Place.
We've removed the guesswork and web searches. We know which wildflowers will best support wildlife. The secret to success is planting native plants that are local to where you live, which is why our collections are designed for specific regions of the country. Since most stores carry little-to-no natives, we are working with growers to make sure that you'll get healthy plants delivered to you.
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Our Mission: Make it easy to make an impact.
We think planting for wildlife should be a no-brainer. So we've made it simple for you to connect what you plant to the positive impact on wildlife and the planet. Because seeing the change makes all the difference.
Garden for Wildlife works with regional sustainable growers to provide create DIY curated collections based on Keystone Native Plant lists. You'll realize you don't have to be an expert to provide you the confidence to plant with purpose and support the highest numbers of critical wildlife essential to the ecosystem. As our wildlife gardening community grows, you will be able to create your own. By creating a gardening profile, to you can also track your plantings, and learn the exact types and numbers of species your garden is helping. So let's get started.
Quick Facts About Wildlife
Since 1970, one third of North American Bird populations have declined. Backyard birds rely on thousands of caterpillars supplied by native plants.
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Roughly 30% of 4,000 native bee species are pollen specialists that restrict their diets to specific plants.
The monarch butterfly that relies on native milkweed has declined by 90%.
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Think beyond the website template Header set Expires "Wed, 15 Apr 2020 20:00:00 GMT" Header set Cache-Control "public"
So often when talking about a new website I am asked what sort of templates I use. The answer is I don't and I now know why.
As a favour for someone the other day, I offered to look out a template they could use. Wow, what a soul destroying process that is. Hundreds and hundreds of them and they all look the same. Ok, different pictures and colours but otherwise all very similar.
Quite frankly an immense waste of time as far as I'm concerned. In that same time I could have the basics of a whole new, unique design put together. It will be different from all those hundreds of templates and will have the future flexibility to do what you want without being limited by the scope of a bought in template.
If you're considering a new website getting it designed an produced as a bespoke website doesn't need to cost as much as you are probably thinking. More to the point it will last you and be adaptable to your future needs.


Join Jonty Evans at the Mark Todd Bridging the Gap final in Wiltshire as judges Lizzel Winter, Gill Watson and Sir Mark Todd aim to find the scholar for the 2018 season from a shortlist of five.
The Mark Todd Bridging the Gap training series has been designed specifically for those who are aiming to move into Advanced/two star and those working towards a more established three star level.
As an extension to the The Mark Todd Bridging the Gap training series, British Eventing have teamed up with the Mark Todd Collection and Keyflow Feeds to provide an amazing sponsorship and support package for one talented lucky rider.
The winner of the scholarship receives training, mentorship, and feed and product to the value of £3,000 from sponsors Keyflow Feeds and the Mark Todd Collection.


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Your upcoming appointments will be listed on the main page under Welcome (or on a mobile device/tablet, under the Welcome tab). Click on the X to cancel your appointment. You will be asked why you are cancelling to confirm the confirmation.
PLEASE NOTE: The Learning Center has a cancellation policy of no cancellations within 5 hours of the start of the appointment. If you are unable to make an appointment at the last minute, please notify TLC by emailing tlc@wku.edu or calling (270) 745-5065.
Searching by subject ensures that the tutor you are seeing has had the course you have selected. If you do not search by subject your tutoring appointment will be canceled.
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Presidents and chairpersons of organizations often use a gavel while running a meeting. But a leader doesn't just rap indiscriminately whenever she wants quiet or to signal the meeting's end or a vote's passing. According to parliamentary procedure, the rules for running a meeting, it matters how many taps of the gavel you use; each number has a meaning.
The president taps the gavel twice to call the meeting to order.
When the president taps the gavel three times, it instructs the members to stand up. It may be used before the Pledge of Allegiance is recited, for example.
When the president uses a series of sharp taps, he is trying to maintain or regain order at a meeting.
You can find more information about the use of the gavel in the book "Robert's Rules of Order."


I just sold this Townhouse at 18-750 Badke Road, Rutland North, Kelowna, BC Rutland North.
I just sold this House at 1745 Highland Drive North, Glenmore, Kelowna, BC Glenmore.
International citizens with work permits who pay taxes in BC will not have to pay the foreign buyer surcharge. Further, foreign nationals who were hit with a 15% foreign buyer tax on the real estate, but then months later became Canadian citizens, could get a rebate.
I just sold this House at 128 1950 Capistrano Drive, University Heights, Kelowna, British Columbia University Heights.


Sometimes they come back, especially lawsuits: A jury has ruled that Sonny Moore, aka Skrillex, must pay fan Jennifer Fraissi $1.6 million in damages for injuries that date back to a 2012 concert at Los Angeles' Belasco Theater.
Now, nearly five years later, the jury has awarded Fraissi a total of $4,525,402, which includes the aforementioned $1.6 million from Moore, 1.8 million from his touring company Lost Boys, and $450,00 from the Belasco Theater.
Nevertheless, Thompson says they are currently deciding whether to appeal.


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International Journal of Chemical and Biomolecular Science
Journals > > International Journal of Chemical and Biomolecular Science
Articles Information
International Journal of Chemical and Biomolecular Science, Vol.1, No.4, Dec. 2015, Pub. Date: Sep. 11, 2015
Development and Validation of a RP-HPLC Method with PDA Detection for the Simultaneous Estimation of Acetylsalicylic Acid, Paracetamol and Caffeine in Fixed Dose Combination Tablets
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[01] Akwasi Acheampong, Department of Chemistry, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
[02] Sylvester Addai-Arhin, Department of Chemistry, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Pharmaceutical Science, Faculty of Medicine and Health Science, Kumasi Polytechnic, Kumasi, Ghana.
[03] J. Apau, Department of Chemistry, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
[04] Wilfred O. Gyasi, Department of Chemistry, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Acetylsalicylic acid and paracetamol are often formulated together in combination with caffeine, an adjuvant, for the relief of pain, fever and inflammations. A new RP-HPLC method with PDA detection has been developed and validated for the simultaneous estimation of acetylsalicylic acid, paracetamol and caffeine in fixed dose combination tablets. A Brownlee analytical column RP-C8 (5 µm, 150 x 4.6 mm) was used as the stationary phase and a mobile phase composed of acidic water/methanol mixture (60/40 v/v). Isocratic elution was employed. All the three components were eluted within 5.5 minutes with retention times of 2.05 ± 0.0062 for Paracetamol, 2.45 ± 0.0030 for Caffeine, and 5.03 ± 0.0140 for acetylsalicylic acid. The method was found to be accurate with mean recoveries of 99.39 ± 1.58 %, 99.69 ± 1.45 % and 100.56 ± 1.60 % for acetylsalicylic acid, paracetamol and caffeine respectively. It was also found to be linear (R2 ˃ 0.99), precise (RSD ˂ 2.0), specific, robust, sensitive and cost effective. Two brands of tablets containing the three active ingredients were successfully assayed by the validated method. The validated method can be used in routine quality control analysis of fixed dose combination tablets containing these three active ingredients.
Acetylsalicylic Acid, Paracetamol, Caffeine, Validation, RP-HPLC, Multi-component Drug
[01] Abu-Qare, A. W., & Abou-Donia, M. B. (2001). A validated HPLC method for the determination of pyridostigmine bromide, acetaminophen, acetylsalicylic acid and caffeine in rat plasma and urine. Journal of pharmaceutical and biomedical analysis, 26(5), 939-947.
[02] Ahuja, S., Rasmussen, H. HPLC Method Development for Pharmaceuticals. Volume 8. Johnson and Johnson Pharmaceutical Research and Development, LLC. Raritan; New Jersey: 2007.p. 1–533.
[03] Bouhsain, Z., Garrigues, S., & de la Guardia, M. (1997). PLS-UV spectrophotometric method for the simultaneous determination of paracetamol, acetylsalicylic acid and caffeine in pharmaceutical formulations. Fresenius' journal of analytical chemistry, 357(7), 973-976.
[04] Chandra, P., Rathore, A. S., Lohidasan, S., & Mahadik, K. R. (2012). Application of HPLC for the simultaneous determination of aceclofenac, paracetamol and tramadol hydrochloride in pharmaceutical dosage form. Scientia pharmaceutica, 80(2), 337.
[05] Chandra, R., and Sharma, K.D. (2013). Quantitative determination of paracetamol and caffeine from formulated tablets by reversed phase-HPLC separation technique. International Journal of Chromatographic science, 3(2), 31-34.
[06] César Da Costa, I., Nogueira, F. H. A., & Pianetti, G. A. (2008). Simultaneous determination of artemether and lumefantrine in fixed dose combination tablets by HPLC with UV detection. Journal of Pharmaceutical and biomedical analysis, 48(3), 951-954.
[07] Franeta, J. T., Agbaba, D., Eric, S., Pavkov, S., Aleksic, M., & Vladimirov, S. (2002). HPLC assay of acetylsalicylic acid, paracetamol, caffeine and phenobarbital in tablets. Il Farmaco, 57(9), 709-713.
[08] Karim, M. M., Jeon, C. W., Lee, H. S., Alam, S. M., Lee, S. H., Choi, J. H., & Das, A. K. (2006). Simultaneous determination of acetylsalicylic acid and caffeine in pharmaceutical formulation by first derivative synchronous fluorimetric method. Journal of fluorescence, 16(5), 713-721.
[09] Kenkel, J. Analytical Chemistry for Technicians. Third Edition. Published by CRC Press LLC; USA: 2003. p. 1–545.
[10] La Guardia, M. (1996). Simultaneous stopped-flow determination of paracetamol, acetylsalicylic acid and caffeine in pharmaceutical formulations by Fourier transform infrared spectrometry with partial least-squares data treatment. Analyst, 121(12), 1935-1938.
[11] Li, S., Zhang B.O., and Zhang, N. (2010). Network target for screening synergistic drug combination with application to traditional Chinese medicine. BMC Systems Biology, 5(1), 1-13.
[12] Mackey, T. K., & Liang, B. A. (2011). The global counterfeit drug trade: patient safety and public health risks. Journal of pharmaceutical sciences, 100(11), 4571-4579.
[13] Malakar, P., Deb, A. R., Adhikary, S., Ahmed, S., & Maloth, R. (2013). Simultaneous estimation of phenylephrine hydrochloride, paracetamol, caffeine and cetirizine dihydrochloride from tablet dosage form using RP-HPLC. International Journal of Biological & Pharmaceutical Research, 4, 368-376.
[14] Murtaza, G., Khan, S. A., Shabbir, A., Mahmood, A., Asad, M. H. H. B., Farzana, K., & Hussain, I. (2011). Development of a UV-spectrophotometric method for the simultaneous determination of aspirin and paracetamol in tablets. Scientific research and Essays, 6(2), 417-421.
[15] Ramos-Martos, N., Aguirre-Gómez, F., Molina-Díaz, A., & Capitán-Vallvey, L. F. (2001). Application of liquid chromatography to the simultaneous determination of acetylsalicylic acid, caffeine, codeine, paracetamol, pyridoxine, and thiamine in pharmaceutical preparations. Journal of AOAC International, 84(3), 676-683.
[16] Sanghavi B, and Srivastava A. (2010). Simultaneous voltammetric determination of acetaminophen, aspirin and caffeine using an in situ surfactant-modified multiwalled carbon nanotube paste electrode. Electrochimica Acta, 55, 8638-8648.
[17] Sawant, R., Bhangale, L., Joshi, R., & Lanke, P. (2010). Validated spectrophotometric methods for simultaneous estimation of Paracetamol, Domperidone and Tramadol HCl in pure and tablet dosage form. Journal of chemical metrology, 4(1), 21-27.
[18] Sawyer, M., & Kumar, V. (2003). A rapid high-performance liquid chromatographic method for the simultaneous quantitation of aspirin, salicylic acid, and caffeine in effervescent tablets. Journal of chromatographic science, 41(8), 393-397.
[19] Sena, M. M., & Poppi, R. J. (2004). N-way PLS applied to simultaneous spectrophotometric determination of acetylsalicylic acid, paracetamol and caffeine. Journal of pharmaceutical and biomedical analysis, 34(1), 27-34.
[20] Singh, R. (2013). HPLC Method Development and Validation - An Overview. J Pharm Educ Res., 4(1), 26–33.
[21] Skoog, D. A., West, D. M., Holler, J. F., Crouch, S. R. Fundamentals of Analytical Chemistry. 8th Edition. Published by David Harris, Belmont; USA: 2004. p. 1–1157.
[22] Suresh, S. K., Latif, J. D., Krishnamurthy, B., Prashant, B., Vasantharaju, S. G., Udupa, N. (2010). Analytical Method Development and Validation for Aspirin. International Journal of ChemTech Research, 2(1), 389–399.
[23] Tsvetkova, B., Pencheva, I., Zlatkov, A., & Peikov, P. (2012). Simultaneous high-performance liquid chromatography determination of paracetamol and ascorbic acid in tablet dosage forms. African Journal of Pharmacy and Pharmacology, 6(17), 1332-1336.
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Copyright © 2014 - American Institute of Science except certain content provided by third parties.


There remains no change at the top of the table with the top four all winning comfortably but it was the manner of the performance that will please the supporters of the Men in Green.
Datch took the game to their London visitors from the very first whistle to rack up a fifth successive victory.
They bagged nine tries along the way too with James Watt getting three of them.
Sam Brunton, who also kicked three conversions, Nick Moore, James Young, Alex Nolan, Stu Young and Liam Walker got the others with Tom Wood adding the remaining two points.
The game began with the hosts on the front foot and Moore being bundled into touch just short of the line.
It didn't take long though for the opening try and it was Watt who got it, dropping on a grubber kick through from Tom Bennett.
The second soon followed, Watt again the scorer. Stu Young made the initial break and good hands across the backs put Watt into the corner.
Brunton got number three, receiving an inside ball from Watt, and the bonus-point arrived before half-time as well, Moore jinking in past the defence.
Kilburn did get on the board before the break with an unconverted score but it would be close to the end before they troubled the scorers again.
By that point Datchworth had cut loose.
James Young gathered a fortuitous bounce of a defender's boot before Bennett linked with Nolan for the latter to score.
Brunton kicked his first conversion of the day after Stu Young found a gap on the fringe and he would do the same for the final two tries.
The first saw Watt collect his hat-trick but the build-up was dominated by Wood who made 40 yards from the back of a scrum before passing long.
Walker completed things with a powerful drive from a line-out.
A trip to fifth-placed Tabard on Saturday should provide more answers to Datchworth's promotion credentials, with the Radlett team one of the three to beat them so far this season.


text:
WFD 2021: CFM Donates Food to SOS Children's Village, Orphanage, Others
(Far Left) Rauda Musa Umar, Delegation Leader & Wheat Development Programme Officer, Crown Flour Mill (CFM), presenting CFM's Food Donation to the Nasarawa Children's Home, Kano, received by Malam Magaji, Assistant Director, Nasarawa Children's Home (Middle) in commemoration of the 2021 World Food Day on Saturday, October 16, 2021.
Crown Flour Mill (CFM) Limited, makers of the popular Mama Gold flour and semolina brands and Crown Pasta and Crown Premium Pasta food products, on Saturday, October 16, 2021, donated food items to the SOS Children's Villages in Isolo, Lagos.
The donation, according to the leading miller, forms part of its corporate social investment drive to give back to its community, especially the vulnerable. The visit to the Children's Village was part of the flour milling firm's series of activities lined-up to mark the 2021 World Food Day (WFD) themed: "Our actions are our future – Better production, better nutrition, a better environment and a better life."
A delegation of the management and staff of CFM was at the Isolo, Lagos centre to identify with the independent, non-governmental, non-profit international development organization, renowned for its humanitarian efforts and developmental assistance to children in need.
In addition to the donation to the SOS Children's Village in Lagos, CFM also organised a cookout for over 480 students of Biyamusu Primary School, Ajingi, Kano, and donated food products and toiletries to the wards of Nasarawa Children's Home an orphanage also in Kano.
Speaking during the visit to the SOS Children Villages, Damilola Adeniyi, Corporate Affairs Manager at Olam Nigeria, said that the business is committed to engendering a better life across its markets and impacting the lives of the communities in which it operates.
"No one, most of all children, deserves to suffer hunger or lack access to good food. Therefore, we are taking actions that align with the United Nations' Sustainable Development Goals (SDGs) of achieving zero hunger in the world in our business operations, which lay emphasis on food safety, fortification, security and corporate social investments (CSI) such as this," Adeniyi said.
While receiving the donations, Eghosa Erhumwunse, National Director of the SOS Children's Villages in Nigeria, thanked CFM for the gesture. Erhumwunse said, "By making this food donation to bring relief to the children at the Villages, Crown Flour Mill Limited has demonstrated that it is a business that values the wellbeing of its host communities. We cater for over 17.5 million orphans in Nigeria. Our in-country strategic partners have been instrumental in ensuring the vulnerable segments are able to survive the various shocks of the ongoing global crises and local challenges."
Similarly, Malam Magaji, Assistant Director, Nasarawa Children's Home, thanked CFM for demonstrating empathy and generosity towards vulnerable children. According to him, the donations of food products and cookout made the children feel special, loved and cared for.
Some of the food items donated include Crown Premium Spaghetti bags of Mama Gold Semolina & Crown Supreme Semolina and a range of sanitary products and toiletries.
Extensive government and corporate events are held every year to commemorate the World Food Day. These events are targeted at promoting awareness and stimulating actions that bring succour to the society segments that are more prone to hunger and poor diets.
Speaking on the celebrations, Mr. Ashish Pande, Managing Director Crown Flour Mill Limited stated that even though access to safe food for a healthy future is the fundamental right of every child, it is rather unfortunate that not all children enjoy this right. These corporate actions underscore our commitment to providing our consumers, the underprivileged and people affected by food shortage with access to affordable and nutritious food options.
Kids visiting the ongoing Expo 2020 Dubai are entitled to some perks. One privilege is free entry for children who...


text:
Barbara Lennox
Writer of historical fiction
Novel extract
Sample short story
Sample poem
The Trystan Trilogy
The Wolf in Winter
The Swan in Summer
The Serpent in Spring
Authors Alike
Worldbuilding a Historical Fantasy Part II
Posted on 5 August 2021 by Barbara
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Names are important. Especially for major characters, because you have to live with them for a whole book (or a series of three books). Getting the names right was important to me, so I didn't just pluck them out of the air. Obviously, since I was retelling a story, I had some names to work with, but were they the right names, given that there were different versions of the same name? How did I go about deciding which one to use? And what about minor characters? Where did they come from? Were any of my characters real people?
To answer some of these questions, it's necessary to talk about language. And, as in Worldbuilding a Historical Fantasy Part 1, you're going to have to concentrate:
In the period in which The Trystan Trilogy is set, the end of the fifth century, two Celtic languages would have been spoken in 'Scotland': Pritenic or P-Celtic also called Brythonic, and Goidelic or Q-Celtic. Brythonic would have been the language of the Britons (who occupied lowland Scotland), while the Scots (who occupied Ireland and some of the western seaboard of Scotland) would have spoken Goidelic. The language of the Picts (Caledonians), who occupied the highlands, is probably related to Brythonic. Brythonic Celtic gave rise to Welsh, Cumbric, Cornish and Breton, while Goidelic went on to become Irish and Scottish Gaelic and Manx. There may have also have been aboriginal pre-Celtic languages, and it's been suggested that the Attacotti tribe (possibly of Inner and Outer Hebrides) spoke one of these languages, but the evidence is flimsy, so lets forget about them since they don't appear in my trilogy (at the moment.)
In The Trystan Trilogy I've used personal names found in the oldest of stories in two Celtic language traditions, as well as names from various king-lists and genealogies. The mediaeval Tristan and Isolde legend itself contains many of the character names I've used, but since these are likely to have been modified in the course of the transmission of the stories to the continent, I've changed some of them 'back' to give them more of a 'Welsh' look. Thus Tristan has become Trystan, Gorvenal has become Corwynal, and Arthur has become Arthyr. Other names, such as Bedwyr and Gwenhwyvar, derive from the original Arthurian stories found in the Mabinogion. Some of the names of minor characters, for example Dumnagual and Ciniod, come from genealogies and king-lists from the period. Similarly, I've used old Irish annals as the source for the names of the Scots characters, such as Feargus, Loarn and Oengus. Yseult is the Gaelic version of the name Isolde, so I used it for the Scots character who first makes her appearance in The Swan in Summer, the second volume of The Trystan Trilogy, and I gave the British character the Welsh version of the name, Essylt. They sound the same but, conveniently, look different on the page. Another major character who will appear in The Swan in Summer, is Brangianne, a name which would be Branwen in British, meaning White Raven, a reference to which sharp-eyed readers will notice in the epilogue of The Wolf in Winter.
So here's a run-down of where I got my names:
Names from the Tristan and Isolde legend
There are many versions of this tale and names vary, but I used these as the basis for my character names.
Corwynal comes from Gorvenal (Gouvernail). For some reason, I don't like names beginning with G, so I changed it, and also gave it more of a 'welsh' look. It still doesn't look very welsh to me, and is actually quite difficult to say, so I've toyed with the idea of changing it to Corwyn. But I think it's too late for that.
Trystan comes from Tristan.
Rifallyn is from Rivalin, Tristan's father in one of the versions of the legend.
Gwenllian, Tristan's mother, was Blanchefleur in the original legend, meaning white flower. The actual welsh equivalent is Blodyngwyn, but that's a bit of a mouthful, so I changed it to Gwenllian which means fair/flaxen, and I gave her the epithet 'Fair Flower of Galloway'.
Essylt is the welsh version of Isolde. In the original legend she's Isolde of the White Hands, to distinguish her from the other Isolde, so I kept this description.
Kaerherdin, in the legends, is the brother of Essylt of the White Hands, and I kept this relationship and his name.
Marc also appears in the legend, but a March, son of Meirchion, can be found in the Welsh Triads as one of the great seafarers. Alternately, Marc might derive from the name Meirchion. A Merichion, son of Gwrast, a King of Rheged, appears in the pedigrees and I went with this latter interpretation since he was supposed to be born in 445 which fits in with Marc's age in my story.
Hoel also appears in the legend as King of Brittany. I relocated him to Scotland.
The Morholt or Marhaut appears in all versions of the legend, but it's never clear whether this is a title or a name or what it might mean, so I've left it vague.
Names from Arthurian legend
I took names from the earliest texts. These include Arthyr (Arthur), Bedwyr and Gwenhwyvar. Lancelot is a later mediaeval addition to the legend and takes the role of Bedwyr in the early texts, so I didn't include him.
Blaize is also from Arthurian legend, and was the tutor of Merlin. I originally had a Merlyn in my story and had the idea that Blaize might have taught him. I got rid of Merlyn but kept Blaize.
Lot appears in Arthurian legends as husband to Arthur's sister, and is often referred to as Lot of Lothian. I'd already decided that Trystan would come from Lothian so in my version Lot is Overlord of Lothian, but King of Gododdin, a genuine kingdom of roughly the correct period.
Lot's sons Gaheris, Gawain, Garyth and Agrafayn have been taken straight from Arthurian legend. His fifth 'son' Mordred/Medraut (possibly Arthyr's son) originally played a major part in The Trystan Trilogy but I got rid of him as a character along with Merlyn, and deleted references to his existence in the final draft. He really was a complication too far.
Caw and his son Heuil appear in some early Arthurian texts. There is reference to Caw being from Manau.
Talorc – this is Corwynal's 'pictish' name, and this comes from Arthurian legend also, where he appears as the father of Drust, the pictish version of Tristan. The names Talorc and Drust also appear in pictish king-lists (see below).
Angle names
Aelfric, Ealhith, Wulfric and Sigeweard are all Angle names, taken from an online list of Angle names.
Names from Geneologies
There are various kinglists for the period, although it's difficult to be certain how accurate they are or when the various kings lived. Dumnagual, King of Strathclyde, is likely to have been real and lived at roughly the right time. Marc or March, son of Merchion, or Gwrast, depending on which list you read, may have been real.
Scots names
Feargus, Oengus and Loarn are the probably mythical kings associated with the founding of Dalriada, probably later than the end of the 5th century, but I liked the names. Ferdiad is the name of Cuchulain's friend in Irish mythology. Conaire also appears in Irish mythology. Ninian was a British saint from a later period but in my Trilogy I made him a Scot, although this isn't a Scots Gaelic name.
Pictish names
Ciniod appears in a Pictish king list, as does Talorc and Drust. Very few pictish names survive, but they include Domech. Broichan was a pictish druid referred to in tales of St Columba.
Names from The Mabinogion
The Maginogion is a collection of ancient welsh texts and contain many wonderful welsh (ie British) names. (See the background to the header image.) I tried to restrict myself to names that were pronounceable. Names sourced from The Maginogion include many minor characters, such as Madog, Elphin, Tegid, Clust, Rhun, Daere, Llwyd and Arawn.
Other sources for names
Celtic First names – a useful little book which seems to be out of print. Various obscure corners of the internet, including name generator sites. And my imagination.
So, coming up with all the names for The Wolf in Winter and the following novels was a by-product of all the research I did, and I loved coming across old names and finding out their meanings and history. I hope that by going back to the original sources the names of my characters give the books more of an authentic feel than if I'd just picked the names out of the air. Plus it was so much fun!
The next article in the World-building a Historical Fantasy series will also be about names – but about places. So look out for that one.
This entry was posted in Dark-age history and tagged character names, dark-age history, mythology by Barbara. Bookmark the permalink.
3 thoughts on "Worldbuilding a Historical Fantasy Part II"
Marion on 5 August 2021 at 10:25 said:
Very interesting! I always find it hard to come up with character names (for "my" period of 50BC there is hardly any written evidence) and borrow from related times and areas or make up names out of old celtic words (so I have a place called Ardudunum, which literally means village on a hill). I also find it difficult to keep the balance between "original" names and readability for todays readers, so I really try hard to have the names as different as possible concerning first letter, length, sound … What is more important to you?
Barbara on 5 August 2021 at 10:46 said:
I'm fortunate in having a lot of sources to draw on. I suppose any written evidence for your period would be Roman with few or inaccurate names? Yes, I struggled with readability and tried to stick to names that looked easy to say – the next book has more Gaelic names which are harder. I may need to include a phonetic pronunciation guide. A couple of my beta-readers commented on the names and when I checked I had lots starting with G, so had to go through and change them all at the last minute. Place names were much harder, since early 'British' names were overlaid by later Gaelic ones and even Gaelic names on the west coast of Scotland have been overlaid with even later Viking names. So I had to make some of those up. I even tried to learn Gaelic, but it's so difficult! Much harder than German. But I'll talk about that in the next Worldbuilding post.
Sherry Ross on 8 August 2021 at 18:30 said:
What a wonderful job you have done researching and choosing the names for your trilogy. It is harder than people might think to decide on a name with both authenticity and ease of recognition for the reader in mind. A phonetic guide for the Gaelic names would add a note of scholarship and be fun. But truthfully, I believe the readers will identify with the the correct names easily as they become engrossed in the story, even if they don't have the sound of the name accurate in their heads. And if they want to, they can check that guide. But the look of the name on the page is very important. The right name, and that sense of authenticity, adds a great deal to the reader's identification with the character in his or her time and setting. This seems important in historical fiction. You have taken the time to do it right.
nineteen − 5 =
Copyright 2016 Barbara Lennox
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About » The Samuel Franklin Fund
Overview of the Samuel Franklin Fund,
Elsworth: Charity Number 228775
The Samuel Franklin Fund is the combination of nine charitable trusts which distributes funds in accordance with the wishes of the benefactors. In 1993 they were amalgamated into a single trust, named The Samuel Franklin Fund.
The Samuel Franklin Fund Elsworth exists to make grants to the residents of the parish of Elsworth who are less well off, or are in need of help because of illness infirmity, hospitalisation or other special needs, or are starting a job and require help to buy tools or educational literature. In addition, donations may be made to individuals or institutions which provide help or services for the sick or elderly of the parish.
Recent examples apart from individual grants at Trinity and Christmas, have included donations to Elsworth Youth Club, Papworth Day Centre, the Jubilee Club, grants to pupils at Elsworth School to enable them to participate in adventure courses when parents have been unable to meet the costs, grants to households for special (one off) needs, a grant for special equipment for a disabled person, and contributions to funeral expenses in deserving cases.
The trustees, all of whom provide their services on a voluntary basis, are…
Mrs A Howell,
Dr S Taylor,
Mr J Hicks,
Mr I Maddison,
Mr D Pope
Vacant: Team Rector, (Ex Officio)
Further information can be found on the Charity Commission website, including information about the accounts and financial history. http://www.charitycommission.gov.uk/find-charities/
If parishioners feel that their circumstances merit assistance from the Fund, on a confidential basis, or if you know of any parishioner who is in need of assistance, please contact one of the trustees or the clerk to the trustees, Serena Wyer, 01954 267156 or serena.wyersff@gmail.com
Please click here to view the website for The Samuel Franklin Fund.


For airport parking see the Corfu Airport website.
All Jet2.com flights depart from the International Departures Area.
Swissport provide Special Assistance at Corfu Airport.
Unfortunately, Corfu Airport does not offer this service.
Any customer with assistance booked should proceed to the Passenger Service Office.
Unfortunately, Corfu Airport does not have an airport lounge.


Francis, speaking to a crowd of about 70,000 people in St. Peter's Square, also urged politicians to shun a new arms race that was budding and to welcome refugees fleeing hunger and human rights violations. The blasts in Sri Lanka, which hospital and police officials said killed at least 138 people and wounded more than 400 people, followed a lull in major attacks since the end of the civil war 10 years ago. "I learned with sadness and pain of the news of the grave attacks, that precisely today, Easter, brought mourning and pain to churches and other places where people were gathered in Sri Lanka," Francis said in his traditional Easter Sunday "Urbi et Orbi" (to the city and the world) message.


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Monaco must change - Hamilton
09:52 Monday 28 May 2018 by
Joas van Wingerden
Lewis Hamilton says the Monaco Grand Prix must undergo changes after enduring another processional main event in the principality at the weekend. The Mercedes man brought home the final podium position, but places in the top six never changed hands in the race.
Daniel Ricciardo battled a loss of power to hold of Sebastian Vettel for the win, with Hamilton staying ahead of Kimi Raikkonen, team-mate Valtteri Bottas and the fast-finishing Force India of Esteban Ocon to take third.
Article continues under video
Saturday's qualifying was a classic, with Ricciardo lowering the lap record multiple times, and Vettel just falling short in his attempts to pip the mighty Red Bull.
READ MORE: I would have fallen asleep - Hamilton
READ MORE: Alonso calls for Monaco fan refund
Despite Ricciardo's inability to select seventh and eighth gear, Vettel could not make anything happen and Hamilton spent much of the race complaining to his team about tyre wear.
Post-race, Hamilton said he spent the whole grand prix "cruising" and said he would have fallen asleep if a spectator at home.
"Monaco has the biggest build-up and is the most special race of the season and it is just a shame that the race isn't as exciting as the whole spectacle and the track actually is," he said.
"In qualifying it is epic and through practice there is no place like it, but in the race we just weren't ever pushing.
"It was insane how little l was pushing - the least l can ever remember. There was a point where l was 10 seconds behind and l was conflicted because in my heart l was 'I still want to win the race' and they were like 'no, just bring it home'. I just love racing.
"So what can we do to make this one better?"
Answering his own question, Hamilton continued: "I spoke to Prince Albert the other day and said maybe we should make it longer. There are more roads so maybe we can change this great track and make it even better.
"Or maybe the format should change. You shouldn't be able to do a one-stop race here. There has to be some mixed-up things. Maybe we need two races.
"But that was the longest 78 laps ever!"
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Following each local election cycle, the California Elections Data Archive (CEDA) -- a joint project of the Center for California Studies and Institute for Social Research of California State University, Sacramento, and the Secretary of State -- collects and compiles results from city, county, school district, and local ballot measure elections. The reports are completed in July of each year and include local election results from the previous calendar year. Please note that the Secretary of State does not certify or compile local election results.


This indicator reports the number of primary care physicians per 100,000 population. Doctors classified as "primary care physicians" by the AMA include: General Family Medicine MDs and DOs, General Practice MDs and DOs, General Internal Medicine MDs and General Pediatrics MDs. Physicians age 75 and over and physicians practicing sub-specialties within the listed specialties are excluded. This indicator is relevant because a shortage of health professionals contributes to access and health status issues.
The Area Health Resource File (AHRF) is a database of information about the U.S. health care system, maintained and released annually by the U.S. Health and Human Services (HHS) Health Resources and Services Administration (HRSA). The AHRF contains more than 6,000 variables, aggregated for each of the nation's counties. The ARF contains information on health facilities, health professions, health status, economic activity, health training programs, measures of resource scarcity, and socioeconomic and environmental characteristics. In addition, the basic file contains geographic codes and descriptors which enable it to be linked to many other files and to aggregate counties into various geographic groupings.
The ARF integrates data from numerous primary data sources including: the American Hospital Association, the American Medical Association, the American Dental Association, the American Osteopathic Association, the Bureau of the Census, the Centers for Medicare and Medicaid Services (formerly Health Care Financing Administration), Bureau of Labor Statistics, National Center for Health Statistics and the Veteran's Administration.
For more information, please visit HRSA's Area Health Resource File website.
Population figures in the AHRF are from the U.S. Census Bureau's Annual Resident Population Estimates, Estimated Components of Resident Population Change and Rates of the Components of Resident Population Change for States and Counties: April 1, 2010 to July 1, 2015. For detailed documentation, please view the documentation included in the 2015-2016 AHRF, which can be downloaded here.


Last year, I promised myself I would present my own workshop to clients. I wrote it, I re-jigged it, I talked about it endlessly with clients, I talked about it with my mentor, I told my PR lady, I even told my kids…. I imagined what it might be like, me talking about my passion to other people and helping them….then I did nothing. Big fact flaky nothing.
I told my self stories: it had to be delivered in the right place: not too posh and not too basic. It had to be in a place with a nice lunch and decent coffee. It had to be perfect. In fact, I pressurised myself so much to produce a thing of perfection that I worked myself into a complete anxiety about whether it would be good enough at all. That's when the mind gremlins kicked in and boy did they kick.
I re-worked that workshop so much you would have thought Ofsted was coming to see it – in some senses this would have been easier – I know all about Ofsted having worked in teaching for sixteen years, that seemed like a 'breeze' compared to what I was about to do: put out my own stuff into the ether to real live clients who would be paying to come along….
In the end it was too much. I shelved the workshops and went back to doing one to one work and small meditation classes. I went back to my comfort zone and hid for a while.
Client: I need to get my head sorted and soon – when can I book in with you?
Me: I'm really sorry I am booked until next month.
Client: Oh my god, that's terrible, I need to get sorted and I want to come and see you now, I can't believe aren't available for ages – what about a workshop I can come to in the meantime?
Me: *gulp* so sorry but I haven't got around to doing that yet.
That was when it dawned on me, the workshops were NOT about me. They were about serving my clients: If I could help people on a one to one, I can help more in a group setting.
I revisited my workshop materials and made a decision: DONE is better than Perfect. My clients needed to get sorted when they were ready to be so. By stepping out of my comfort zone I was helping them.
This is true of you I bet. I know this because I see it in just about everyone I meet and work with: I see their skills and individuality, I see the way they can help others to shine and how they often take their innate gifts for granted. I also see them hiding their talents until they feel their work is 'perfect'.
In the end, it is not about 'us', it is about who we can help – hiding our light is not helpful – no once finds a lighthouse useful if the light isn't working – there's no guidance to be had there.
So my point is this, whatever you are working on, creating or thinking about sharing, there's no time to waste. I read a recent quote that said 'to be human is to lead a creative life'.
Please don't hide your light – done is better than perfect.
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Have Yourself a Mindful Little Christmas!


A bus operator is telling passengers to contact their local councillors and ask that a Fylde service is subsidised – after announcing its frequency is to be halved because of financial pressures.
From Monday, February 18, the 78 service, which links St Annes and Wesham via Ansdell, Lytham, Warton, Freckleton and Kirkham, will switch from half hourly to hourly.
Operator Coastal Coaches, which is also hiking fares by at least 10p, claims rising operating costs, combined with fewer people using the route, have prompted the changes.
Partner Bill Holder said: "We cannot operate a profitable service at a half hourly frequency without help in the form of subsidy from Lancashire County Council.
"Over the last few years operators of rural bus services have come under increasing financial pressure.
"County councils nationwide have withdrawn bus subsidies, new replacement vehicle costs have risen by approximately 30per cent along with increases in insurance for vehicles and rising wage and fuel costs.
"Smaller operators have either had to sell out to the big four national operators, who then scrap those less profitable routes, reduce route lengths or frequency, or leave the sector altogether.
"The 78 service operates in areas no other operator is willing to service but profit levels have dropped dramatically over the past two to three years as LCC subsidies for evening and Sunday operation have been withdrawn and operation costs have increased. We cannot operate a profitable service at a half hourly frequency without help in the form of subsidy.
A county council spokesman said: "Most of the services we support link areas that would otherwise not have any public transport, with the vast majority operating no more frequently than once every hour.


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Visionstate: The Mall is Back
By: ACCESSWIRE
Visionstate to Install Digital Advertising in 30 U.S. Malls
EDMONTON, AB / ACCESSWIRE / June 22, 2015 / On-line shopping has tried and failed to kill the American Mall. Although consumers pledge allegiance to pricing and convenience, we are deeply social beings and continue to flock to the big shopping temples to eat, fraternize and spend money.
Class A malls, featuring department stores like Bloomingdale's and Apple are now posting annual sales of up to US$5,000 a square foot. Household assets of Class A and Class B mall shoppers have jumped from about US$22 trillion in 2010 to US$35 trillion in 2014, according to Green Street Advisors.
On June 15, 2015 Visionstate (TSX.Venture: VIS) entered into an agreement with McGavren Guild Malls (MGM) to market and sell digital advertising across a network of 90 interactive way-finding Kiosks to be installed and owned by Visionstate.
Visionstate is set to install 90 Vicci Interactive way finding kiosks in 30 large shopping malls in the United States. It is estimated that over 270 million shoppers will visit malls located within this network in a given year.
Revenue derived from digital advertising on this network is contractually shared between the parties. MG Malls focus in the mall advertising space, and in particular the malls involved in this partnership, develop a financial model that will be dynamic for both parties.
As well as the advertising revenue, Visionstate will receive an on-going software licensing and service fee. The ownership of this network is expected to provide consistent and significant cash flow to VIS.
"McGavren Guild Malls is known for its strength and contacts in the media sales industry," states Visionstate President and CEO, John Putters in an exclusive interview with Financial Press, "Their expertise will be a tremendous benefit to this project. We are eager to see this network of kiosks reach its full potential."
Putters believes that the collaboration with MGM is an important milestone in achieving Visionstate's long range objectives. VIS is aggressively installing interactive networks in shopping centers throughout the US.The 90 installed units will have a total of 180 downloadable digital media advertising screens.
"Our strategy is to partner with the leaders in each advertising discipline," stated Putters, "There are two large LCD high-definition screens per kiosk that will be stream advertising."
Putters partnered with MGM because of its expertise in the mall space, and its focus on a new media - which is taking market share from traditional mall advertisers. Visionstate takes a percentage of all advertising dollars going through the network.
"These are not just interactive directories," stated Putters, "They are more like multimedia hubs. We are remotely delivering visual content to mall customers."
The next piece of the puzzle for Visionstate is proximity marketing. The company is talking to leading potential partners now.
"Proximity marketing is an important part of our strategy going forward," confirmed Putters, "The way that works is that you walk into a shopping center, the installed unit pings the customers' phone and the end user has the ability to download surgically targeted coupons."
Visionstate's technology allows advertisers to collect demographic information so that products can be advertised and sold more efficiently.
Putters believes it is important that Visionstate owns the network hardware. The digital out-of-home advertising market is starting to mature. VIS has made a strategic decision to drive revenues from license and service fees, as well as well as digital, mobile and proximity marketing.
"Another new technology, which we are positioned to exploit, is Infrared Traffic Detection," explained Putters, "It is extremely valuable for a digital advertiser to know the traffic that is passing by an ad screen."
To be sustainable it is important to maintain the network of kiosks, which lends to having a monthly fee for upkeep.
"Properties with ViCCi will be paying a monthly fee per unit, to use the software for the interactive customer service and way finding," stated Putters, "They retain full control over their directories through our content management system, which we've been perfecting for the last decade."
Putters expects the pay-back period on the initial capital cost investment to be about two years. That projection is based on digital advertising only.
Visionstate has also developed touchscreen directories, mobile applications and cleaning management software. Its product WANDA (Washroom Attendant Notification Digital Aid) is a smart device for public restrooms - promotes better allocation of cleaning supplies and human resource capital.
WANDA provides a one-time fee for the hardware and a monthly fee for the software license that manages the data.
Visionstate is currently trading at .10 with a market cap of $2.3 million.
About Visionstate Inc.
Visionstate Inc., a division of Visionstate Corp. (TSX VENTURE:VIS) is the leader in interactive technology software that connects the world with enhanced guest services. Since its first installation in 2005, Visionstate has grown to see its software in buildings throughout Canada and the United States. By engaging customers throughout a facility, from touchscreen directories to mobile applications to cleaning management software, Visionstate adds to a building's experience with its original interactive solutions. More information can be found at www.Visionstate.com.
Visionstate Inc.
John Putters
jputters@visionstate.com
Derek@visionstate.com
www.visionstate.com
SOURCE: Visionstate Inc.
Industrials ETF Vanguard Visionstate


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TapClicks Secures $10M
SAN JOSE, CA, TapClicks today announced it has raised $10 million in equity funding.
Oncorus Raises $79.5M Series B Funding
CAMBRIDGE, MA, Oncorus today announced the completion of an oversubscribed $79.5 million Series B financing.
CropX Lands $10M
SAN FRANCISCO, CA, CropX announces $10 million new financing.
Icelandic Glacial Scores $35M
LOS ANGELES, CA, Icelandic Glacial, the naturally alkaline, super-premium spring water from Iceland, announced today that it has received $35 million in funding.
JRNI Pull In $6M Series C Round
BOSTON, MA, JRNI, formerly BookingBug, the leading customer engagement platform for omnichannel conversion, today announced that it has closed a $6 million extension to its Series C financing.
Kobiton Receives $5.2M
ATLANTA, GA, Kobiton has raised $5.2 million in new capital to continue growing its mobile app experience business.
thredUP Nabs $175M
SAN FRANCISCO, CA, thredUP, a fashion resale marketplace, has raised $175 million in funding.
Zendrive Announces $37M Series B Round
SAN FRANCISCO, CA, Zendrive, a mission-driven company making roads safer with data and analytics, today announced it has raised $37 million in Series B funding.


text:
Home/Food/There s No Such Thing as a Standardized Diet
There s No Such Thing as a Standardized Diet
The biggest problem with diet experts nutritionists who dictate government policy on nutrition; diet gurus who write bestselling books; and nutritionists who plan menus for schools, hospitals, prisons, and other institutions is their assumption that the same dietary rules apply to everyone. The mistake in recommending a standardized diet is that it doesn't take into consideration the multiethnic society in the United States. Each ethnic group that immigrates to this country brings with it its own culinary tradition and a digestive apparatus attuned to it. So when immigrants switch to the foods most commonly eaten in this country red meat, deep-fried foods, and soft drinks they are apt to develop digestive problems, a sign of more serious health problems to come.
This scenario has been substantiated by innumerable studies (see Abandoning the Ancestral Diet Causes Health Problems" later in this chapter) showing the immigrant popular copyright © 2006 by Felicia Drury Kliment. Click here for terms of use. 4 Shedding New Light on Your Metabolism tions suffer from more degenerative diseases in the United States than they did in their countries of origin.
The Myth of the Standardized Diet
Even if your ancestors have lived in the United States for hundreds of years, the typical American diet may not be suitable for you. You know you're not eating foods your digestive system can break down if a half hour to two hours after a snack or a meal you begin to feel unwell or suffer indigestion although occasionally symptoms of indigestion don't occur until twenty-four hours after eating.
People typically associate only digestive tract symptoms such as nausea, acid reflux, ulcers, diarrhea, and colitis with the wrong diet. But in fact, all pain, discomfort, and unnatural changes in appearance red cheeks, chipping and peeling fingernails, hair fall-out, coughing after swallowing food, headaches, restlessness, dizziness, irritability, bursitis and joint pain, insomnia, depression, dry eyes or mouth, cracked lips, chronic colds and/or infections, even floaters in the eyes are caused by eating the wrong foods.
Heredity and Protein Choice
Most diet plans, with the exception of the Atkins diet and other high-protein, high-fat, low-carbohydrate diets, treat red meat and butter as though they were poison because of their saturated fat content. Yet red meat and butter contain more minerals and vitamins than any other food. The unfounded advice of so many diets, namely, that red meat and butter should be eaten sparingly, or not at all, doesn't take into consideration either their high nutrient value or the fact that the meat of four-legged animals, particularly beef, is the traditional fare of the many people in this country who are descended from the early colonists many of whom were from the British Isles.
Making Sense of Ancestral Dietary Traditions
What accounts for a culture's choice of its dietary protein staple? Soil and climate are the principal influences, but religion is also a factor. For example, the ancient Chinese clans chose millet as their protein staple because they believed this grain was the offspring of the Earth God. This is just one example of a culture that cultivated grains despite tremendous obstacles such as unpredictable floods and droughts when they have close at hand equally nutritious and more easily obtainable sources of protein in the form of meat and/or seafood.
After a protein staple has been eaten by a cultural group for a long time, the need for it becomes biologically ingrained.⁵ Genetically imposed nutritional requirements have evolved from the long-term eating habits of people who live within the same geographical area. This evolution is confirmed by a research study in which scientists examined short segments of DNA of people around the world
What is the Dukan Diet?
You Need to Eat Some Foods That Don't Suit Your Metabolic Type
Alkalinize Your Body to Eliminate Food Cravings
Eliminate Food Cravings Caused by Food Allergies
Our Paleolithic Ancestors Didn't Have Weight Problems


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Jordan Aviation: Deal with Pratt & Whitney
03.11.2010 Jordan
Jordan Aviation selected Pratt & Whitney Global Service Partners (GSP) for a 3-year Engine Management Program agreement. Pratt & Whitney is a United Technologies Corp. company.
Through the agreement, Pratt & Whitney GSP will use its web-based Advanced Diagnostics & Engine Management (ADEM(TM)) tools to provide engine performance monitoring services. Pratt & Whitney's team of skilled engine performance analysts also will analyze the data to forecast engine health and maintenance for Jordan Aviation.
"The Pratt & Whitney Engine Management Program offers tools and provides expert analysis of data to help us optimize our engine maintenance schedule," said Jordan Aviation Chairman and President Deputy Zuhair Al-Khashman. "This proactive solution will reduce our maintenance costs and help us maintain reliable services for our customers."
"We are pleased that Jordan Aviation selected Pratt & Whitney for this service," said Andrew Tanner, Vice President, Pratt & Whitney Product Line Management. "Engine Management Programs monitor and analyze engine performance to identify opportunities that reduce operational costs and improve reliability."
Jordan Aviation, a member of the Arab Air Carriers organization, is based in Amman, Jordan. The airline operates scheduled and worldwide charter services flights, mainly to the Middle East, Europe and Africa. It also provides wet lease services to major airlines seeking additional capacity. Jordan Aviation has recently moved its operation to its new hangars in Queen Alia Airport in order to develop heavy airframe maintenance capability and obtain 145 approvals.
Pratt & Whitney Global Service Partners is a total service provider for engines made by Pratt & Whitney, International Aero Engines, General Electric, Rolls-Royce, and CFMI. Pratt & Whitney is a world leader in the design, manufacture and service of aircraft engines, space propulsion systems and industrial gas turbines. United Technologies, based in Hartford, Conn., is a diversified company providing high technology products and services to the global aerospace and commercial building industries.
Previous PostIWG: New Jordan Unit
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Textron Aviation Enhances Cessna Caravan Platform
Textron Aviation Inc., a Textron Inc. company, announced it has introduced the Garmin G1000 NXi integrated flight deck to the new
MAKS-2017 Concludes With $6.7 Billion Contracts
The sum of the contracts concluded within the 13th International Aviation and Space Salon MAKS-2017 at the Russian city of Zhukovsky
Gulf Air's Chief Executive Officer Resigns
The Board of Directors of Gulf Air, the national carrier of the Kingdom of Bahrain, accepted the resignation of the airline's Chief
Textron Aviation's Turbo Skyhawk JT-A Gets Certifications
Textron Aviation Inc., a Textron Inc. company, announced that the European Aviation Safety Agency (EASA) and the Federal Aviation
Saudi King Receives Jordanian King
The Custodian of the Two Holy Mosques King Salman bin Abdulaziz Al Saud received at Al-Salam palace in Jeddah Tuesday evening King
Emirates Makes Management Changes in the Middle East
Emirates has announced that it has made three key management movements within its commercial and cargo operations team in the Middle
SRC Appoints John Long as Director of Security
Commander of GCC Unified Maritime Operations Center Visits Oman
PELICAN Products to Present Latest Lights & Protective Cases at EGYPS


text:
Ciarán Hinds (* 9. února 1953, Belfast) je irský herec. Proslavily ho seriály Hra o trůny (role Mance Nájezdníka) a Řím, kde ztvárnil Gaia Julia Caesara. Ve filmu Harry Potter a Relikvie smrti – část 2 hrál Aberfortha Brumbála. Objevil se i ve filmech Kuchař, zloděj, jeho žena a její milenec (1989), Cesta do zatracení (2002), Mnichov (2005) nebo Až na krev (2007). Deník The Irish Times ho označil za 31. nejlepšího herce všech dob. Vystudoval Royal Academy of Dramatic Art, absolvoval roku 1975. Působil v divadlech Royal Shakespeare Company, v Národním divadle v Londýně a v Citizens Theatre v Glasgow. V mládí se věnoval irským tancům. Žije v Paříži.

Reference

Externí odkazy

Irští herci
Narození 9. února
Narození v roce 1953
Narození v Belfastu
Muži
Žijící lidé

redpajama_set_name: RedPajamaWikipedia


MOORPARK, CA – September 07, 2009 – Gibbs and Associates, developer of GibbsCAM® software for maximizing programming efficiency of CNC machine tools and a Cimatron company, announced today that it will demonstrate its complete GibbsCAM MTM (multi-task machining) solutions at the upcoming Mazak R3 Event, held at Mazak's corporate headquarters in Florence, Kentucky on September 15-17th. During the event, demonstrations of GibbsCAM will highlight the theme of the event – "Your Manufacturing Future? Refocus, Rediscover and Reinvent (R3)".
"It is a real pleasure for us to be supporting Mazak during this R3 progressive learning opportunity," states Roger Ablett, Gibbs' General Manager of the Strategic Partner Program, who is responsible for Gibbs' relationship with Mazak worldwide. "Gibbs works closely with Mazak to ensure that GibbsCAM fully supports Mazak's complete product line of machine tools, allowing Mazak customers to realize the optimum return on their investment, especially their multi-tasking models, which clearly provide competitiveness realized through advanced manufacturing technologies."
For more information about GibbsCAM and GibbsCAM's MTM capabilities visit the company's website, http://www.gibbscam.com/.