The settlement deal requires Apple to pay Qualcomm and also includes a six-year licensing agreement.
Investors reacted as if it were a resounding victory for Qualcomm. The San Diego company's stock soared 23 percent to close Tuesday at $70.45. Apple shares edged up 2 cents to $199.25.
Neither Apple nor Qualcomm would comment beyond a brief statement announcing they had resolved their differences. Details about how much Apple and its iPhone suppliers will be paying Qualcomm could emerge in court documents or when the companies announce their latest financial results. Apple is due to report its quarterly results on 30 April while Qualcomm is scheduled to release its numbers on 1 May.
Falling behind the competition isn't something Apple can afford with its iPhone sales already falling.


I am getting random supreme stars but when I click claim item "Backpack" it says "your prize has been automatically redeemed" and it automatically sticks them all on fletching? I have no idea why and I don't want bonus exp in fletching.
Any ideas? Is there some random setting to automatically redeem in certain skills??


text:
Brunehamel ist eine französische Gemeinde mit  Einwohnern (Stand ) im Département Aisne in der Region Hauts-de-France (vor 2016 Picardie). Sie gehört zum Arrondissement Vervins, zum Kanton Vervins und zum Gemeindeverband Portes de la Thiérache.

Geographie
Der Fluss Brune entspringt auf dem Gebiet der Gemeinde. Brunehamel grenzt im Osten an das Département Ardennes. Umgeben wird Brunehamel von den Nachbargemeinden Aubenton im Norden, Mont-Saint-Jean im Nordosten, Les Autels und Résigny im Südosten, Parfondeval im Südwesten, Dohis im Westen sowie Iviers im Nordwesten.

Bevölkerungsentwicklung

Sehenswürdigkeiten
 Kirche Saint-Nicolas

Weblinks

Ort in Hauts-de-France

redpajama_set_name: RedPajamaWikipedia


text:
Granada estuvo representada en los Juegos Paralímpicos de Tokio 2020 por dos deportistas femeninas. El equipo paralímpico granadino no obtuvo ninguna medalla en estos Juegos.

Referencias

Enlaces externos

Granada
V 2020
Granada (país) en 2021


A fundamental feature of cerebral cortical organization is that positions of its neuronal constituents into horizontal (laminar) and vertical (radial) arrays ultimately define their connectivity and function (1). Cortical neurons acquire appropriate positions by migration from the site of their origin in the proliferative zones lining the cerebral ventricle, according to a precise schedule (2, 3) and along well defined pathways (4–6). When the rate of neuronal migration and the sequence of arrival are altered because of genetic and/or environmental factors, various consequences, including abnormal behavior, have been observed (7–13). In terms of orientation and directionality of movement, neuronal migration to the cerebral cortex can be classified into radial (proceeding radially from the ventricular to the pial surface) (5, 14) and tangential (running parallel to the brain surface) (15–17). Contact interaction between migrating neurons and the surfaces of neighboring cells plays a decisive role in selecting the migratory pathway and determining their final position (18, 19). Neuronal migration involves translocation of the nucleus and the surrounding cytoplasm with the leading process, which requires rearrangement of the cytoskeleton (20, 21). As a consequence of these complex cellular and molecular interactions, the process of neuronal migration is highly sensitive to a variety of biological, physical, and chemical agents, as well as to specific genetic mutations (7–13). For example, repeated exposure of the rodent and primate fetal brain to environmental agents, such as alcohol (9), drugs (22), neurotrophic viruses (23), and ionizing irradiation (24, 25), causes misplacement of neurons and behavioral deficits.
To our knowledge, the effect of ultrasound waves (USW) on the rate of migration in the cerebral cortex has never been tested, although it has been reported that the exposure of pregnant mice and non-human primates to USW may affect the behavior of their exposed offspring (26, 27). There also is some evidence that the frequent exposure of the human fetus to USW is associated with a decrease in newborn body weight (28, 29), an increase in the frequency of left-handedness (30), and delayed speech (31). In addition, it was reported that diagnostic levels of ultrasound can disrupt membrane attachments or cells both in vitro (32, 33) and in vivo (34) and alter the cell cycle of the intestinal epithelium in vivo (35). Because ultrasound energy is a high-frequency mechanical vibration (36), we hypothesized that it might influence membrane-mediated, cell-to-cell attachments and/or nuclear translocation essential for neuronal migration. Because the migratory neurons and the adjacent radial glial guides in the embryonic brain are surrounded by extracellular spaces filled with low-viscosity fluids (5), the USW might affect cell motility through radiation force or microstreaming (36). In this study, we examined the possible effect of USW on neuronal migration in mice at a late stage of corticogenesis, when the migratory pathways are the longest and, thus, may be most vulnerable.
Pregnant mice were injected on embryonic day (E)16 with the DNA-replication marker BrdU to label dividing cells in the proliferative zone destined for superficial cortical layers 2 and 3 (37). Then, within the next 3 days, while these cells were migrating across the cerebral wall, the animals were exposed to multiple sessions of USW in a specially designed experimental system (Fig. 1). The total exposure to USW ranged from 5 to 420 min, delivered in multiple individual sessions (Table 1). The controls were subjected to identical procedures, except for exposure to USW. The pregnancies were brought to term (E19), and the pups were nursed by their mothers and then euthanized on postnatal day (P)10. The brains were fixed, sectioned in the coronal plane, and stained with propidium iodide to show cortical lamination, followed by immunocytochemical staining of the BrdU to expose the final positions of cells generated at E16 (Fig. 2 C–H). Double-labeling with neuron-specific marker NeuN (BrdU/NeuN) showed that the majority of cells (USW, 89.5 ± 0.6%; control, 88.4 ± 3.8%) generated at E16 in controls and USW-exposed animals are neurons, irrespective of their position (Fig. 3 A–C). The remaining 10–12% of BrdU-labeled cells are either neurons that were not labeled with NeuN or glial cells. In selected specimens, the BrdU cells were double-immunolabeled with markers for superficial-layer (Brn1) or deep-layer (FoxP2) neurons. To assess the pattern of migration and positioning of E16-born cortical neurons, the number of BrdU-labeled cells within a grid made up of 10 equally sized bins (Fig. 2 E and H) was imaged and counted by investigators blind to the experimental conditions, followed by statistical analysis.
The experimental design of the system used for exposure of pregnant mice to USW. The mouse is placed in the tube chamber with abdomen embedded in conductant jelly and separated from the transducer by a tissue stand-off pad (TSP). Diagnostic levels of USW were delivered during 5–45 min. The embryos were monitored on the screen, and pulse, oxygenation, and temperature in the mothers were recorded (35).
Examination of the routine histological preparations did not reveal a difference in brain size and cytoarchitectonic organization between the control and USW-exposed animals (Fig. 2 A–C and F). In the counterstained sections from the controls, the majority of BrdU+ cells accumulated, as expected, in bins 2/3, which roughly correspond to superficial cortical layers 2/3, whereas a small number of BrdU+ cells were scattered in the lower bins (Fig. 2 D and E). In contrast, in many mice exposed to USW, BrdU+ cells were more dispersed, as illustrated in the cortex of a P10 mouse exposed in utero to USW for a total of 60 min (Fig. 2 G and H). More specifically, layers 2/3 contained usually a smaller number of BrdU+ cells, whereas the deeper layers and the underlying white matter contained more of such cells (Fig. 2 G and H). In some cases, ectopic BrdU+ cells formed a distinct band near the lateral cerebral ventricle (Fig. 2 H, white arrowheads) that resemble periventricular ectopias. When these ectopic BrdU+ cells occurred, it was easy to distinguish the exposed brains from the control brains, even upon visual inspection of the immunostained sections (Fig. 2, compare E with H). However, detailed quantitative analysis was needed to discern the change in pattern of cell dispersion in most cases and to expose the systematic difference between the two groups of animals.
The pattern of distribution for BrdU-labeled cells was highly variable; therefore, to quantify the degree of their deviation from the norm according to exposure time, BrdU-counterstained cells were plotted for controls and the mice were exposed to USW for various durations (Fig. 4 and Table 1). Examination of the brains of mice exposed multiple times for a total of 420 min (12 exposures, 35 min each exposure), 210 min (7 exposures, 30 min each exposure), 60 min (2 exposures, 30 min each exposure), and 30 min (2 exposures, 15 min each exposure) of USW, respectively, showed a consistent overall pattern of a smaller number of BrdU+ cells situated in the upper cortical layers and a greater number in the lower layers and throughout the subcortical white matter, compared with control brains (Fig. 4 A–D). This difference in cell pattern was statistically significant (t test; see Table 1). In animals exposed to USW for 15 and 5 min, the effect was not statistically significant (Fig. 4 E and F). However, when the data were pooled together, across all durations, mice exposed prenatally to USW as a group contained a smaller percentage of BrdU+ cells in the upper cortical layers (e.g., bin 2) and a larger percentage in the deeper layers as well as in the subcortical white matter (bins 4–10), compared with the controls (Fig. 4 G). In addition, the majority of ectopic BrdU+ cells located in layer VI and the subjacent white matter were double-labeled with NeuN (Fig. 3 A–C) and did not stain with lower cortical layer markers such as FoxP2 (Fig. 3 D–F). Furthermore, some of these ectopic BrdU+ cells still retained upper-cortical-layer markers, such as Brn1 (Fig. 3 G–I), which suggests that these cells were neurons destined to superficial layers that were arrested along their migratory pathway and not located in their proper position.
Percentage of cells in each bin averaged across all animals in each exposure duration, shown by condition. (A Left–F Left) Line graphs showing the percent of cells in each bin for experimental and control animals for exposure durations of 420, 210, 60, 30, 15, and 5 min, respectively. For durations >15 min, the proportion of cells in the lower five bins was significantly higher for exposed than for control animals. (A Right–F Right) Line graphs showing the ratio of the percentage of cells in ultrasound-exposed versus control animals (U/C) for each bin. For durations >15 min, the small differences in the absolute magnitudes in the lower bins represent large proportional increases. (G) (Left) The average percentage of cells in each bin for all 146 experimental animals and 141 sham controls across all durations. Note the excess of cells in the lower bins for the exposed animal. (Right) Line graph showing the ratio of the percentage of cells in ultrasound versus control animals for each bin. The small difference in the absolute magnitudes in the lower bins represents large proportional increases.
Detailed examination of the effect of USW exposure at each duration and across all durations showed that the best individual-level measure of cell dispersion was the proportion of BrdU+ cells found in the lower half of each brain section within bins 6–10 (Fig. 5 A and B). Multiple linear regression analyses of over 218,000 BrdU+ cells obtained from 1,722 scans of 287 brains (146 exposed and 141 control) indicate that USW have an effect on final neuronal positioning in the mouse cerebral cortex (P < 0.0001) (Fig. 5 A and B). For example, under the experimental conditions used, doubling exposure time from 15 min to 30 min increased the number of cells in the lower layers from 5% to 9%. Increasing exposure to 60 min increased dispersion to 11%, which was a statistically significant level (P > 0.0001). At 210 min, the mean increase of 9% did not fit the expected response curve but was in the expected direction. However, at a total of 420 min exposure, we observed the largest dispersion of 19%. Although the results at shorter durations are relatively small, we do not know whether a 4% increase in dispersion of cells, as seen from the difference between 5- and 15-min exposures, is sufficient to compromise the normal cerebral cortical functions (Fig. 5 A).
Dispersion of BrdU+ cells for USW and controls by duration of exposure. Dispersion is defined as the percentage of cells in bins 6–10. (A) The mean dispersion by condition and duration, with error bars showing the standard errors. (B) The mean dispersion for control and experimental animals across all durations with the Y-bars showing the standard errors. (C) A scatter plot by condition and duration for USW (red) and sham control (blue) conditions. Dispersion increases systematically with the length of exposure to USW. Dispersion also increases with sham exposure, although not as quickly as with ultrasound. (D) A scatter plot by condition with 0 min of duration for normal controls. The mean dispersion for the normal control condition was not significantly different from the 5-, 15-, 30-, 60-, and 210-min exposures. NC, normal control.
The cumulative dose–response curve using all seven experimental groups indicates that longer ultrasound exposure causes a larger effect (Fig. 5 C), with a trend toward a smaller percentage of cells being in the upper cortical layers and a larger percentage in the lower layers and the white matter. Interestingly, there also is an increase in dispersion in the 420-min sham condition over normal controls (Fig. 5 C and D). This increase in cell dispersion may be due to the indirect effect of stress experienced by pregnant animals during prolonged exposure to the experimental procedure. Although the sample size at 420 min is small (two litters, seven sham pups and seven USW-exposed pups) (Table 1), the possibility of the role of stress in causing cell dispersion at long exposures during cortical development is worthy of a more detailed examination.
To further test the possibility that stress alone increases dispersion, we compared statistically all sham control conditions versus the normal control condition (Fig. 5 C and D). The normal control condition had a mean dispersion of 6.1% with an SD of 2.2% and an SE of 0.6% (n = 30) (Fig. 5 D and Table 1). A post hoc comparison of all of the means using the Student–Newman–Keuls test indicated that the normal controls were not statistically different from the sham controls with 5, 15, 30, 60, and 210 min of exposure but were different statistically from the 420-min exposure. This finding indicates that the stress due to the experimental procedure at durations of 210 min or below did not play a significant role in causing the cell dispersion seen in the sham conditions. At durations of 420 min, it is possible that the stress of this long exposure leads to increased cell dispersion above the normal control condition. However, it is difficult to completely assess durations of 420 min and above because some pups from USW-exposed mothers were either resorbed or cannibalized at birth (Table 1). In fact, no pups survived to P10 in pregnant mice exposed to 600 min of USW, although the sham control mouse gave birth to a full liter that survived until P10 (data not shown).
To confirm our results, we performed one more independent experiment with a more advanced and current ultrasound system (see Material and Methods) and a different operator. Four of nine pups from a litter exposed to USW for 60 min exhibited ectopic BrdU+ cells forming near the lateral cerebral ventricle (Fig. 7F, which is published as supporting information on the PNAS web site), similar to that seen with the original ultrasound system (Fig. 2 H). No pups were affected like this in any of the nine pups of the sham control litter (Fig. 7C). These types of periventricular ectopias also were not seen in normal control animals.
This study shows that exposure of the embryonic mouse to USW can affect neuronal migration in the cerebral cortex and thereby prevent some neurons from attaining their final proper position. Because this effect is relatively small, it is not possible to predict the magnitude of dispersion in any single case. In fact, the control brains also contained a variable number of neurons scattered within the white matter, and we have even encountered exceptions in which individual brains from the control groups displayed a seemingly abnormal distribution of BrdU+ cells. The variability encountered within the exposed group of animals indicates that there may be large individual differences in susceptibility. However, the linear arrangement of the embryos in the U-shaped mouse uterus precludes their equal exposure to USW and may contribute to the variability of the effects observed. Thus, USW has a predicable effect only when the large population of exposed animals is compared with unexposed controls by using multiple regression analysis and only at total exposure durations of 30 min or longer.
The cellular and molecular mechanisms of the effect of USW on migrating neurons observed in this study are unknown. At the frequencies and intensities we have used (see Material and Methods; see also Supporting Text, Tables 2–5, and Figs. 8–14 which are published as supporting information on the PNAS web site), it is unlilely that cavitation or temperature changes play a role in the effects noted (36). The dosimetry data and output parameters suggest that the mechanism may be a nonthermal, noncavitational, mechanically mediated effect, perhaps involving radiation force or microstreaming, or shear effects on cellular walls (38, 39). These mechanical effects could interfere with the delicate adhesion between the migratory neurons and the surface of migratory substrates, such as radial glial shafts, which serve as guides (5, 6, 14). The USW may also disturb exocytosis, essential for the extension of the leading tip of migrating neurons or disrupt cytoskeletal rearrangement essential for the translocation of the nucleus within its leading process (18, 20, 21, 37). Based on the present results, the effect on other forms of cell motility, such as tangential neuronal migration (13, 15, 17) or spinning of the mitotic spindle (40), cannot be excluded. Finally, although we cannot fully estimate the contribution of the indirect, humorally mediated effect of stress caused by the exposure of pregnant mothers to the experimental procedure, it appears to play a role only in extended exposures (420 min) based on comparisons between normal control durations and all sham control durations.
One plausible model of the observed effect of USW on cellular events in the fetal cerebral wall is illustrated in Fig. 6. Normally, cells generated in the proliferative ventricular zone at E16 migrate radially during the next two days (E17 and E18) and settle to the prospective layer 2/3 to be bypassed by the subsequently generated, unlabeled neurons that settle mostly above them in the upper tiers of layer 2 (Fig. 6). We hypothesize that, if cells generated at E16 that were en route to the cortex were slowed by exposure to USW, some of them would not arrive on time at the most superficial position between the developing cortical plate and the marginal zone (Fig. 6 G). As a result, these cells become intermixed with the earlier-generated neurons within the lower cortical layers or remain in the subjacent white matter (Fig. 6 H). The ectopic cells would then develop abnormal synaptic connectivity resulting in behavioral deficits, as has been observed in the mutant mice with malposition of neurons (7). These ectopic cells can also cause abnormal electrical discharge associated with epilepsy (10).
Schematic representation of the progression of neuronal migration to the superficial cortical layers in the normal mouse. (A–D) Most cells labeled with BrdU at E16 arrive in the cortex by E18, and, by P1, those cells become surpassed by subsequently generated neurons. Eventually, these cells will settle predominantly in layers 2 and 3 of the cerebrum. (E–H) Model of the USW effect. When cells generated at E16 are exposed to USW, they slow down on E17, and some remain in the white matter or are stacked in the deeper cortical layers.
Perhaps the most obvious question raised by these results is their possible relevance for cortical development in humans. The principal ultrasound beam characteristics (beam width, time-averaged intensity, and mechanical and thermal indices) used in this study were well within clinical norms for fetal exams. Although the frequency used in the present study was slightly above standard obstetrical clinical practice (6.7 MHz versus 3.5–5.0 MHz), the latest ultrasound equipment with three-dimensional reconstruction and tissue harmonic imaging often employs even higher frequencies. The pulse average intensity was slightly above Food and Drug Administration guidelines, but the exposimetry measurements were set up as worst-case (full water path) scenarios, and the levels measured at the location of the fetuses are not considered excessive. In addition, in our exposures, the ultrasound parameters and total exposure time are comparable with or below those used by commercial medically nonindicated prenatal ultrasound videos.
There are, however, huge differences in the number of neurons and the size of the cerebral cortex between mouse and human (41). Thus, in spite of the use of tissue stand-off pad, the distance between the exposed cells and transducer in our experiments is shorter than in human. Furthermore, the duration of neuronal production and the migratory phase of cortical neurons in the human fetus lasts ≈18 times longer than in mice (between 6 and 24 weeks of gestation, with the peak occurring between 11 and 15 weeks), compared with the duration of only ≈1 week (between E11 and E18) in the mouse (2, 4, 16). Thus, an exposure of 30 min represents a much smaller proportion of the time dedicated to development of the cerebral cortex in human than in mouse and, thus, could have a lesser overall effect, making human corticogenesis less vulnerable to USW.
There are also some reasons to think that the USW may have a similar or even greater impact on neuronal migration in the human fetal brain. First, migrating neurons in the human forebrain are only slightly larger than in the mouse, and, with the acoustic absorption provided by the tissue stand-off pad, the amount of energy absorbed within a comparable small volume of tissue during the USW exposure was in the same general range (Supporting Text, Tables 2–5, and Figs. 8–14). Second, the migratory pathway in the convoluted human cerebrum is curvilinear and at least an order of magnitude longer (4). Thus, the number of neurons migrating along the same radial glial fascicle, particularly at the later stages of corticoneurogenesis, is much larger and their routes are more complex (42), increasing the chance of a cell going astray from its proper migratory course. Third, the inside-to-outside settling pattern of isochronously generated neurons in primates is more precise than in rodents (3, 6) and thus, the tolerance for malpositioning may be smaller. In addition, different functional areas in the primate cortex are generated by different schedules (43) so that exposure to USW may potentially affect selective cortical areas and different layers, depending on the time of exposure, potentially causing a variety of symptoms.
In conclusion, it is not known whether or to what extent USW affects migrating neurons in developing humans. Identifying the position of isochronously generated neurons requires the technique of labeling DNA replication, a procedure that cannot be used in humans; therefore, the misplaced solitary cells in the cortex due to migratory disturbance could be missed upon neuropathological examination. The problem of detection is exacerbated by the small number of ectopic cells and the need for quantitative analysis to detect them. However, it is important to emphasize that even a small number of ectopic cells might, as a result of specific position and inappropriate connectivity, be a source of epileptic discharge or abnormal behavior. Although we have not as yet generated behavioral data, previous studies in rodents and primates indicate that prenatal exposure to USW may affect higher brain function of the offspring (26, 27). Furthermore, there are numerous human neuropsychiatric disorders that are thought to be the result of misplacement of cells as a consequence of abnormal neuronal migration (e.g., 8, 10, 12, 22–24). Therefore, our results in pregnant mice support the recommendations by the Food and Drug Administration that warn against the use of medically nonindicated or commercial prenatal ultrasound videos (44). Our results also call for careful testing of the nonthermal effects of USW at the potentially vulnerable intense period of cortical neurogenesis in the human fetus (45). Furthermore, it is essential to examine the possible effects of USW on cortical development in non-human primates, where the duration of embryogenesis and the size and complexity of migratory pathways are more similar to those in humans.
An unanesthetized pregnant mouse was held in position within an exposure chamber made from a cardboard tube; the lateral surfaces of the tube had been cut to allow exposure of the mouse's abdominal wall to the ultrasound transducer (Fig. 1). The posterior half of the mouse body was embedded in acoustic gel. A water bag was acoustically coupled to the side of the mouse opposite the transducer to minimize the possibility of standing waves or reflections that might affect the exposure. The mouse's abdomen was shaved to ensure proper acoustical coupling between the ultrasound transducer and the skin.
For ultrasound exposure, we used an Ultramark 4 Plus (ATL, Bothell, WA) ultrasound system and an Access 10 transducer (frequencies 5M, 7.5S, and 10S). We selected an ultrasound system that has been routinely used in human medical clinics (36), and we used a 2-cm-thick tissue stand-off pad over the abdomen of unanesthetized pregnant mice. Unanesthetized pregnant mice were exposed to B-mode, 6.7-MHz, pulsed USW with a pulse duration of 0.2 ms and a scanning rate of 11 frames per second for 5–35 min in different schedules, total duration, and pregnancy time points (Table 1). A 2-cm-thick stand-off pad was placed between the transducer face and the abdomen of the mouse. The stand-off pad positioned the fetuses in the nearer uterine horn at the probe's focal point (2.1 cm, with a focal range from 1.3 to 4.0 cm). Dosimetry testing of the ultrasound system showed spatial peak pulse average intensities (I sppa) of 330 W/cm2, and spatial peak time average intensity (I spta) of 1.5 mW/cm2 when measured in water. The estimated I sppa at the fetal locations was on the order of 1 W/cm2 (see Quantification of Ultrasound Exposure and Supporting Text, Table 2, and Figs. 9–14 for ultrasound output parameters for the system). For the single confirmatory experiment done by using a different ultrasound system, a M2540A ultrasound system (model M2540-67000; Phillips, Bothell, WA) was used with a 15-6L transducer.
In an independent group of anesthetized exposed and sham control animals, pulse and oxygenation were monitored during the procedures by using a Novametrix pulse oxymeter (model 513; Medical Systems, Wallingford, CT). The thermistor data logger LogR (Barnant Company, Barrington, IL) was used to assess rectal/core temperature in treated animals and sham controls. Our data showed that there was not a statistically significant change in either pulse rate or core temperature in animals exposed to ultrasound.
The ultrasonic output parameters of the ATL UltraMark 4 Plus system were measured according to published international standards (46, 47) and the current measurement guidelines of the U.S. Food and Drug Administration (48) and by using the appropriate calibrated measurement equipment (Acoustic Measurement System measurement tank and software and Bilaminar Membrane Hydrophone model S5 with preamplifier; Sonora Medical Systems, Longmont, CO) (49). Measurements were conducted without the ultrasonic stand-off pad, which resulted in a worst-case exposure condition. Table 2, which is published as supporting information on the PNAS web site, summarizes the relevant output parameters at 2.5 cm from the transducer face, which would correspond to the depth of the fetuses when using a stand-off pad. The results are shown for the values directly measured in a water tank ("In water") and estimates of tissue exposure parameters ("Attenuated") according to the methodology of the Food and Drug Administration (44). For comparison, also listed in Table 2 are the current regulatory limits for medical diagnostic ultrasound equipment intended for fetal applications ("FDA limit").
In addition to the standard output reporting methodology, measurements were taken to determine the effect, if any, of reflections from the contralateral side of the mouse during scanning. A euthanized 16-week pregnant mouse was shaved on both ventral sides and interposed between the ultrasound transducer and the measurement hydrophone in the same orientation and distance as was done in the exposure experiment. The results indicated that there was little possibility of a reflection adding substantially to the exposure at the fetuses. The final experiment was conducted to measure the actual ultrasound exposure at the fetuses, by inserting a needle hydrophone (Pinducer transducer; Valpey–Fisher, Hopkinton, MA) through an incision on the contralateral side of another anesthetized 16-week pregnant mouse. Multiple measurements were made and averaged; the results can be found in Table 3, which is published as supporting information on the PNAS web site.
At 8 a.m., pregnant mice carrying E16 fetuses received an i.p. injection of BrdU (50 mg/kg) and were then exposed to diagnostic ultrasound in multiple sessions for a total of 5, 15, 30, 60, 210, and 420 min, cumulatively, during the E16–E18 period (Table 1). In the 5- and 15-min experiments, the animals received a single exposure of USW for 5 and 15 min, respectively. This range was meant to approximate that of exposures used in humans. The first ultrasound exposures commenced 12 h after the BrdU injection. In the 30-min experiments, two 15-min exposures were given at 12 and 24 h after the BrdU injection. In the 60-min experiment, two 30-min exposures were given at 12 and 24 h after the BrdU injection. In the 210-min experiment, eight exposures lasting 30 min each were administered. In this case, the first exposure began 8 h after the BrdU injection. In the 420-min experiment, 12 exposures lasting 35 min were given every 4 h. The first exposure also started 8 h after the BrdU injection. In multiple exposure experiments, we changed the side of the exposure with every subsequent treatment.
In addition to the ultrasound-exposed and sham control animals, three additional pregnant dams were injected at E16 with BrdU and placed immediately in the animal care facility without handling until each came to term (three litters with 30 pups total). The P10 offspring were analyzed by using the same methodology as the other two conditions, and these data served as the normal control condition.
The pregnant mice each received a single i.p. injection of 5 mg/ml BrdU dissolved in 0.9% NaCl with 0.007 M NaOH, at a dosage of 50 mg per kilogram of body weight, ≈12 h before beginning the exposures. All pups were euthanized at P10 and perfused with 4% paraformaldehyde. Any experiment in which the control and ultrasound pups were born more than 24 h apart was not included in the analysis. The brains were removed and drop-fixed for 48 h. Three coronal slices from each brain were used for quantification. Sections 100 μm thick were cut on a standard vibratome. The slices were treated with 2 M HCL for 20 min at room temperature, washed three times for 10 min with PBS, and incubated in anti-BrdU at 1:100 (Becton Dickinson, Franklin Lakes, NJ) for 48 h at 4°C and species-specific fluorophore-labeled secondary antibodies at room temperature. The slices were then counterstained with propidium iodide and mounted in Vectashield (Vector Laboratories, Burlingame, CA). Images from a single optical section were taken with a confocal LSM 510 NLO system (Zeiss, Thornwood, NY) with a 25 × 0.8 numerical aperture Plan-NEOFLUAR lens. Images were collected from the medial somatosensory cortex of all animals (Fig. 2). Images were merged into one montage spanning from the pia to the ependymal surface, and BrdU+ cells were counted in PhotoShop 6.0 (Adobe Systems, San Jose, CA). Six montages from each brain were counted. A 10-tiered grid was overlaid on top of the montage, and positively labeled cells were assigned to each tier depending on their placement (Fig. 2). The bottom line of tier 1 started at the top of cortical layer II, and tier 10 ended in the white matter. Each tier was equal in width and height. All imaging and counting were done blind to experimental conditions.
For double-labeling studies, slices were incubated with anti-BrdU at 1:100 (Accurate, Westbury, NY) and anti-NeuN at 1:200 (Chemicon, Billerica, MA), FoxP2 at 1:1,000 (Abcam, Cambridge, MA), or Brn1 at 1:1,300 (Santa Cruz Biotechnology, Santa Cruz, CA) for 48 h at 4°C followed by species-specific, fluorophore-labeled secondary antibodies at room temperature. The slices were then counterstained with ToPro-3 (Molecular Probes, Eugene, OR) and mounted in Vectashield (Vector Laboratories). A stack of five optical slices separated by 2 μm each was taken at images near the ependyma. Counts for the double-labeling of NeuN and BrdU were taken from three montages spanning from pia to ependyma from one control brain and one USW brain exposed for 30 min.
The data were organized for analysis by summing the cell counts for each of the 10 bins across all six slides for each animal (Table 1). The dependent measure, dispersion, was calculated for each animal by computing the percentage of cells found in the lower five bins (bins 6–10). A multiple linear regression model was used to estimate the independent contributions of ultrasound and of treatment duration to dispersion. (Treatment duration may have an independent effect because prolonged handling is stressful for a pregnant animal.) The model predicted dispersion from condition (ultrasound or sham control), duration of treatment, and their interaction. DISPERS = a + b 1·COND + b 2·DUR + b 3·COND·DUR + error (Table 1).
We are grateful to C.-Y. Kuan, S. Landis, D. Purves, B. Shaywitz, S. Shaywitz, and G. M. Shepherd for advice and comments on the paper. Statistical analysis was performed by Leonid Rozenblit (Prometheus Research, New Haven, CT). This work was supported by the National Institute of Neurological Disorders and Stroke, National Institutes of Health.
Author contributions: E.S.B.C.A., V.G., M.E.S., and P.R. designed research; E.S.B.C.A., V.G., A.D., and M.E.S. performed research; E.S.B.C.A., V.G., A.D., M.E.S., and P.R. analyzed data; and E.S.B.C.A., V.G., M.E.S., and P.R. wrote the paper.
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(2004) FDA Consum. Mag. 38(1), available at www.fda.gov/fdac/features/2004/104_images.html .
(1982) in Histology and Histopathology of the Nervous System, eds Haymaker W. , Adams R. D. (Thomas, Springfield, IL), pp 3–145.
(2003) Acoustic Output Measurement Standard for Diagnostic Ultrasound Equipment, Standards Publication UD 2-2003 (Natl. Electric. Manuf. Assoc. Rosslyn, VA) Revision 1.
(2003) Standard for Real-Time Display of Thermal and Mechanical Acoustic Output Indices on Diagnostic Ultrasound Equipment, Standards Publication UD 3-2003. (Natl. Electric. Manuf. Assoc. Rosslyn, VA) Revision 2.
(1997) Information for Manufacturers Seeking Marketing Clearance of Diagnostic Ultrasound Systems and Transducers (Food and Drug Admin, Rockville, MD).
(1988) in IEEE Trans. Ultrason. Ferroelectrics Freq. Control 35(2):102–109.
Our unborn children at risk?
Ultrasound and Autism: Association, Link, or Coincidence?
Misplacement of Purkinje Cells during Postnatal Development in Bax Knock-Out Mice: A Novel Role for Programmed Cell Death in the Nervous System?


So, what goes into a tea named after the terrifying tale of Ichabod Crane and the Headless Horseman? Pumpkin, of course. (The story goes that the horseman had the head of a pumpkin.) Add to this a select blend of herbs and spices, chai mix, cinnamon and ginger pieces. The taste of Sleepy Hollow Pumpkin Chai, it goes without saying, is to die for!
Learn more about this chai blend here.
I previously reviewed the Sleepy Hollow Pumpkin Chai from Culinary Teas, however, this appears to be a slightly different tea! The tea that I reviewed back in 2011 had candy sprinkles in it, and this doesn't. Perhaps everything else is the same except for the sprinkles … if that is the case, then I'm revisiting this chai!
To brew this, I used my Kati tumbler. I placed a heaping bamboo scoop of tea into the basket and then I poured boiling water into the tumbler. I let it steep for 3 1/2 minutes. And the aroma wafting out of my tea tumbler right now is warm and spicy and pumpkin-y and … so delightfully autumnal!
This is really yummy. I like that I taste the ginger and I can taste the cinnamon. The spices are very warm; the ginger packs a peppery punch! I suspect that there may be pepper in this too, although the website doesn't offer an ingredient list so I can't be certain. But there is definitely some peppery heat that warms the back of the throat. Don't take that as my inferring that this is too spicy, though, because it's a moderate heat, there's just a really pleasant gingery/peppery note to it.
The black tea is smooth and rich. It's not quite as robust as I would have expected, but I like the smooth flavor and it's nicely round. It's a satisfying flavor. There's not a lot of astringency to the tea. It's really pleasant.
I found the pumpkin to be somewhat reserved a flavor at first. It wasn't until I had consumed about 1/4th of the cup that I started to pick up on the sweet-savory pumpkin notes and at that point, they were rather delicate. As I continued to sip, the pumpkin notes developed and now I'm discovering more delicious pumpkin-y flavor.
This chai is a really delightful Halloween treat!
Green Detox Tea from Monarch Tea Co.


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Testimony Delivered Before the Committee on Public Safety
Deborah Lauter, Executive Director for the Prevention of Hate Crimes - February 10, 2020
Mayor's Office for the Prevention of Hate Crimes
Committee on Public Safety
Good afternoon, Chair Richards and members of the Public Safety Committee. I am Deborah Lauter, Executive Director of the Office for the Prevention of Hate Crimes (OPHC). On behalf of OPHC, which is a unit in the Mayor's Office on Criminal Justice, we thank you for the opportunity to testify regarding Intro. No. 1847-2020, relating to responses to violent hate crimes.
Let me begin by saying that hate has no place in New York City, a city celebrated for its diversity. And no New Yorker should ever feel targeted or unsafe because of the race, ethnicity, religion, sexual orientation, gender identity or disability. I want to thank the Council for its leadership in creating the OPHC and for your input and support since its inception. While of course it is expected that our elected leaders condemn hate crimes after they occur, you have taken action to do something greater — to enable a tangible effort that will prevent hate from taking hold in the first place. Our city's holistic approach is the first of kind in the country and I can share that it has received very positive support not just from New Yorkers, but from across the nation and indeed, from around the world. Many are looking to this initiative as a model to address the disturbing widespread rise in hate incidents.
Office for the Prevention of Hate Crimes (OPHC)
At this time last year, the New York City Council passed legislation to create an Office for the Prevention of Hate Crimes – the very legislation that is under consideration for amendment today. That legislation provided that the new office should be open by November. Mayor de Blasio, concerned about the continuing rise in hate crimes, escalated launching the office, which was announced with my appointment on September 3, 2019.
I am pleased to report that in just five short months, we have accomplished much, including completing the administrative work of opening a new office – we are now fully staffed with seven full-time employees.
One of my priorities over these first months has been to engage deeply with different communities across the city, particularly those who are vulnerable to bias incidents and hate crimes. I have spoken at over 50 meetings in all five boroughs and have solicited input from dozens of leaders from religious, education, and community based organizations, as well as academic institutions and think tanks. This has helped me identify areas where City government could take a more active role convening stakeholders and augmenting and innovating new tools. In these meetings and town halls I have heard the voices of concern, of frustration, of fear — but also of optimism, energy and resolve to engage in what many of us see as not just the fight against hate, but the fight for the soul of civility and the right to respect.
These first months have necessitated particular attention to the Jewish community because of the increase in hate crimes motivated by anti-Semitism, particularly targeting the religious Jewish communities in Brooklyn, and in the wake of the horrific attacks in the neighboring Jewish communities in Jersey City and Monsey, NY.
At the same time, the Office for the Prevention of Hate Crimes has also been dedicated to addressing the unique issues and concerns of other communities that are vulnerable to bias incidents. The LGBTQ community experienced the second highest increase in hate crimes last year, including violent assaults and we have been at their side speaking out and working with them to address strategies to combat this disturbing trend. We have engaged with leaders in the Muslim, Sikh, Asian, Hispanic, Black, immigrant, as well as LGBTQ communities who report that their constituents, too, are experiencing an upsurge in bias-motivated incidents and hate crimes, yet most of these incidents are going unreported.
One of the goals of the Office for the Prevention of Hate Crimes to address this problem of under-reporting, not only so that we can show support and get help for victims, but also so we can fully understand the scope of the problem and recommend strategies and resources to address it. Much of this work is being done through our management of the Hate Violence Prevention Initiative (HVPI) which City Council funded through discretionary grants. Participating organizations include the Arab American Association of New York (AANYC), the Center for Law & Social Justice at Medgar Evers, Desis Rising Up & Moving (DRUM), the Center for Anti- Violence Education (CAVE), Project Witness, New York Anti-Violence Project (AVP), the New York Immigration Coalition (NYIC), and United Jewish Organizations of Williamsburg (UJO) and the Jewish Children's Museum. We have been overseeing those contracts and convening the full cohort of 15 participating organizations. With Council support, our office has empowered and enabled them to share their challenges and their best practices with others who are engaged in grassroots efforts.
As part of our mandate under the legislation to perform a coordinating role for the City, OPHC has also formed an Interagency Committee for the Prevention of Hate Crimes (IAC), and convened eleven city agencies and the City's five District Attorney offices, all of whom are stakeholders in preventing and addressing hate violence. By bringing them together with an intentional focus on addressing hate crimes, the Office for the Prevention of Hate Crimes is breaking down silos and engaging educators, first responders, victim service providers, restorative justice advocates, and other subject matter experts. Interagency Committee representatives are sharing information about current programs, resources, and best practices and engaging together in creative thinking and recommendations that will have long-term impact.
I have dedicated almost three decades of my civil rights and human relations career to combating stereotypes, prejudice, discrimination, hate and extremism at the state, national and global levels. I am gratified that I can now focus my skills and expertise to benefit New York City. What I
have shared with city agencies, community organizations, elected officials, media and others is that there is not one way to fight hate. It requires a multi-pronged approach. And so I have set forth a three-pillar strategy for the Office for the Prevention of Hate Crimes, focused on education, community relations, and law enforcement.
I am pleased to report that we are already making significant progress with respect to our education mandate. In December, we partnered with the Department of Education to create resources on promoting respect and addressing hate crimes and Chancellor Carranza sent them to 150,000 educators in the system, urging them to have conversations with their students about the rise in hate crimes and making clear that anti-Semitism, racism and all forms of hate and bigotry will not be tolerated in our school system. We also helped facilitate a partnership between the DOE and the Museum of Jewish Heritage to provide an opportunity for 14,000 students from Brooklyn to tour the Museum's exhibit, Auschwitz. Not Long Ago, Not Far Away, with families of students 12 and over to receive free tickets to the Museum. This initiative will educate students and their families about the consequences of hate through powerful images and survivors' stories. We have also been working with the DOE to develop new curriculum resources on hate crimes which will be introduced and available to teachers city-wide in the 2020-21 school year.
With respect to community relations, in addition to our work with the HVPI, at the end of December the Mayor announced a new initiative: the formation of Neighborhood Safety Coalitions. These coalitions, consisting of leaders from community-based organizations, houses of worship, civic associations, tenant associations, community boards, businesses, and community school districts, will address neighborhood safety issues with an intentional focus on preventative measures and programs that will have long-term impact. Neighbors will come together to break down stereotypes and build healthy relationships that foster safety and social cohesion.
Last week, the Office for the Prevention of Hate Crimes hosted a joint inaugural meeting of the three coalitions, made up of leaders from the greater Borough Park area, Crown Heights and the Williamsburg/Bed Stuy communities. The theme of "CORE Values NYC" guides their efforts to create action plans and programs, with the "CORE" acronym standing for Community Of Respect for Everyone.
Last week I had the privilege to participate in a remarkable program that was organized by Community School District 14 Superintendent, Alicja Winnicki, in Williamsburg. Rabbi David Niederman of the UJO and I engaged in a thoughtful, powerful discussion with student leaders and then a school walk with the superintendent, principal, CEC members, student advisors, and students from neighborhood schools. This program has also been done successfully by Rabbi Eli Cohen from the Crown Heights Jewish Community Council in partnership with Geoffrey Davis, Director of the Stop Violence Foundation. We are now looking to expand this model across the Neighborhood Safety Coalition communities, with the enthusiastic support of the Community
School District Superintendents of District 17-Crown Heights, and District 20-Borough Park, who are both members of their respective Neighborhood Safety Coalitions.
To further advance community education, the Office is overseeing the development of new advertising and social media campaigns to confront prejudice, encourage mutual respect, and empower anyone who is a victim of a hate crime to come forward and report it.
And last, but not least, law enforcement. I am proud to sit here alongside the NYPD, who have been vital partners not just in responding to hate crimes, but in seeking ways to address preventative solutions. Commissioner Shea's presence at so many community meetings and the tone he has set for the whole department to take seriously and address the increase in hate crimes has been exemplary. We believe his commitment to community policing, initiatives focused on youth, as well as the new intelligence unit to address racially and ethnically motivated extremism, are all critically important measures. We also were extremely pleased to see the Commissioner's positive response to the Council's request to include hate crimes statistics in CompStat, which we believe is a significant step in heightening awareness and improving response to hate violence. I also want to commend and thank Deputy Inspector Mark Molinari who heads up the NYPD Hate Crime Task Force as he has been especially helpful in providing guidance and partnership to the Office for the Prevention of Hate Crimes as we have gotten off the ground.
Intro. No. 1847-2020
When a hate crime is committed, there is an urgent desire — particularly among those who share the victim's identity — to know what has happened, what steps are being taken to respond, and what the outcomes will be. Our elected officials also are eager for information about hate crime incidents to better respond to the inquiries and needs of their constituents. The Office for the Prevention of Hate Crimes recognizes the importance of this "need to know" embodied in Intro. 1847-2020 today, and supports the intent of these amendments. We are currently exploring effective, responsible methods of notification that preserve the integrity of an investigation and, at the same time, provides assurance to all parties that an incident is being handled appropriately.
We want to thank the Committee again for convening this hearing today and to express our appreciation for the tremendous support demonstrated by leaders at every level of government and by organizations and individuals all over our city. We support the goals of this amendment and are committed to working with the Council on how to operationalize this bill and uplift communities so that all New Yorkers and visitors feel welcome and safe.
Thank you for your attention. I welcome your questions.
New York Post December 16, 2020
Notorious Brooklyn landlord couple also ran shoddy, illegal Airbnbs: suit
Brooklyn Daily Eagle October 23, 2020
New York City expands its Alternative to Incarceration programs
City Alternative to Incarceration Program Expands
Major Milestone Reached in City's Commitment to Close Rikers Island Jails

redpajama_set_name: RedPajamaCommonCrawl


Not many events are run on a Saturday but South Reading MCC run most of their enduros from Ashdown Park Blewbury near Oxford and are always held on Saturdays which is a nice change as you can recover on the Sunday and sort out bike etc.
Anyway i was Erikaless which also meant Teamsnapperless as she was doing a green lane day along with her best friend Rachel organised by EPM which is a girl only enduro/green lane training club, i am sure she will blog on here later and tell you all about it, anyway not having my organiser and better half helping me and not a camera in sight i arrived nice and early (theres a surprise lol), parked next to Dan Brundell and had good chat and then the masses started to arrive, notably Shane Babey and his motley crew in their nice new van(what recession), Neil Houghton, Darren Giggs, Keith Workman, Rob Taylor, James Giiddings, Terry Carter and Tim Harvey (Ex touring car champion and current Porsche Super cup driver), signing on and scrutineering is a doddle with SRMCC as all very simplistic, was also good to see Peter Lawry who was clerk of the course and also top rider Rich Warner who was there helping out and told me he has retired from enduros for the foreseeable future but will still do his twin shock MX racing which he is also a dab hand.
My objective was to finish an event which i have not managed this year as i just seem to fall off so much i get very despondent, which makes Erika's life happier as i retire after a couple of laps and get camera out and put my Teamsnapper head on which i also enjoy so very much.
I course was nearly 6 miles and started off down a whoopy long dropping field which then turned into a 6th gear flat out climbing flat field (was very fast), then a sharp left into a dense single track wood which was very rutty and whoopy in places it also had a couple of climbs and drops which caught alot of riders out, it then opened out into a meadow that had some massive badger holes which were blind until you were on top of them and for first couple of laps there were a few over the handle bar moments as very quick meadow, that went into a very loose flinty climb and across another flint field which again was top gear flat out and then stamping on the brakes to another tight wooded section which was not as dense but strewn with leaves, roots and many logs and needed a lot on concentration.
We then came out into Ashdown Farms main yard and access road which again was very fast, this then dropped down into a very tight small rooty tricky section which opened out into the famous Ashdown MX circuit (Bottom section)which has massive (Scary) climbs and drops and very much heart in the mouth stuff, then climbed into some very tricky woods and onto the top MX circuit which although dry it was very slippery and saw many riders come off and the ground was very hard indeed. The last bit of this superb course was a winding fast trail like ride through the trees into a small meadow and back to timing pads, it really was a course that had everything and a very well thought out.
I myself went the wrong way on the first lap where i lost a lot of time and then held up Tim Harvey through some tight woods (Sorry Tim). Eventually i got into a rhythm and started to enjoy, had a couple of very silly off's during the first 2 hours which didn't affect me however at 2 hours 15 mins i tried to be clever and overtake a slower rider, going down a climb and i went straight over the edge, over the bars and head butted tree which definitely dazed me as very confused for a while, the bike cartwheeled a few times.
When i eventually got myself together, i was in a ravine where no one could see me, it took all my energy and strength to get bike up and back up the ravine and i can honestly say i have not been so knackered since my Royal Marine training days, i was totally spent and had lost all my mojo and rhythm and thought i will call it a day. I was about 4 miles from start and i must have fallen off countless times over those 4 miles, i was that spent! As i came into pit area Shane Babeys motley crew (Having retired) were waving me on with bucket loads of encouragement which was enough to spur me on till the end but the last 2 laps were very hard as no rhythm and so very knackered..... but i finished and although my Midwest FE390 Husaberg is a bit worse for wear and i can barely move today i had a great time and still smiling.
Would also like to mention and thank all the riders who are wearing their Teamsnapper hoodies and beanies and Teamsnapper decals all over their bikes at various events.


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New FIFA patch reportedly allows EA to block access to FUT in certain countries
By:Semir Omerovic - Ghost
Published: 10:17, 08 December 2020
The newest troublemaker in town
A new patch for FIFA 21 was released today, and apparently, it added a code which allows EA to block access to Ultimate Team in certain countries, due to gambling laws.
FIFA's Ultimate Team mode has been under the loop in recent years as many governments have started to take action against loot boxes, which have been labelled as gambling. As expected, EA have tried to fight against these claims but it seems this is a losing battle for the publisher, who recently got ordered by Dutch judge to pay 250.000 Euro per week as long as loot boxes stay in the game.
And it seems that EA have started to accept the fact that certain governments simply won't allow such practices. In the latest update for FIFA 21, EA have added a code that would allow them to block FIFA Ultimate Team in countries that banned predatory loot boxes due to their gambling laws.
And believe it or not, EA decided to blame the countries for not allowing the mode. Here's the message that will seemingly be displayed once EA block the mode: "FIFA Ultimate Team is currently not accessible due to a demand from the authorities of your region."
Controversial indeed but we would not expect anything less from California-based company. At the time of writing, we are yet to see reports of the mode being blocked but we will update the article if such claims start to surface on social media or gaming forums.
For more Fifa related news, check out the recent comparison between the PS4 Pro and PS5 version of the game.
Ibrahimovic's agent: It's always about money, EA has been dodging us for years
Popular footballer Zlatan Ibrahimovic has been quite vocal lately in regards to EA Sports' likeness rights, or what he claims are lack thereof, and now his agent Mino Raiola doubled down on the stance.
FIFA 21 on PC won't have next-gen features, EA explain why
EA say FIFA 21 PC version will not get the next-gen features coming to PlayStation 5 and Xbox Series X|S in order to keep the system requirements as low as possible.
David Beckham coming to FIFA 21 Ultimate Team, Volta as a freebie
EA Sports have announced that David Beckham, the footballer who needs no introduction, will be coming to FIFA 21 players as a freebie, provided you play the game by January 15, 2021.
FIFA 21 gets a game-changing feature on next-gen consoles
If you're one of those people who were silently (or very loudly) wishing to not have to select a language every time you start FIFA, then you are very much in luck, as the next-gen edition of the game has kissed that chore, yes - chore, goodbye.
Ibrahimovic on EA: They don't own me, but they do owe me!
Zlatan Ibrahimovic's feud with EA Sports doesn't seem to be cooling down as the famous footballer took to Facebook to post EA's earnings with FIFA games, insisting they owe him.
FIFA 21 Next-gen trailer leaves us thirsty for more
The latest trailer for Next-gen FIFA 21 hits the bar, and leaves us holding our heads with both hands, but many new implemented features are sounding very promising and we can't wait to upgrade our FIFA 21 on December 4.
Disney announce Star Wars video games will adopt Lucasfilm branding
Disney have officially announced that Lucasfilm Games is now the identity for all their gaming titles. This means that future Star Wars games will adopt Lucasfilm branding instead of EA, who are usually behind the development of the games.
FIFA 21 Next-gen: How to fix performance issues on PlayStation 5
FIFA 21 does not exactly run brilliantly on PlayStation 5 with the default settings. Getting the optimal performance for EA's football mammoth requires some mild tinkering with the controller settings, and this guide will show you how to do it.
The next Dragon Age game will be revealed at The Game Awards
BioWare have officially confirmed they will offer an early look at their next Dragon Age adventure during the upcoming The Game Awards Show, which is scheduled for December 10, 2020.
FIFA 21 Next-gen is here, one day before the official release
FIFA 21 Next-gen upgrade is officially coming tomorrow, December 4, but it's available right now for PlayStation 5 and Xbox Series X, and Xbox Series S owners.


Reggie Bush's alleged baby mama's saying it loud and clear ... her kid's gonna need a LOT of stuff.
We've obtained the Miami nightclub waitress' baby gift registry ... containing more than 140 pricey items. If she gets her wish list, the baby's clothing will be tucked away in a $700 dresser, he or she will chill in a $500 chair with mom and get pushed around in a $700 stroller.
TMZ broke the story, the woman -- Monique -- has lawyered up and is gunning for child support from Reggie. We're told there's been no DNA test so far ... but Reggie will own up if it's his.
Monique's due in February ... and if Reggie's feeling generous, the entire registry will set him back just around $7,500.


I would like to tell my story, as the Eighth Amendment referendum campaign has brought everything back to me. My husband and I were thrilled when we discovered I was pregnant, with our first child.
The usual excitement and morning sickness etc.. was not just for the first three months, but much, much, longer, and as I thought that this was all quite normal, I did not worry.
Our child was born three days after our 1st wedding anniversary.
Not hearing the child cry at the delivery, I realised that something was wrong. I asked the gynaecologist if there was a problem, and he said the he would talk to me when he had finished suturing me up.
I had been given three sleeping pills and an injection, the night before the delivery, to sedate me, as the doctors knew what was coming, but I did not.
What the injection was, I don't know, but been a nurse myself, I decided that three pills, were too many and decided to take only 2 tablets, so I was heavily sedated, but still conscious, when baby was born.
Back in my room, the Night Nurse, who couldn't have been more kind and compassionate, told me that I had had an anencephalic baby. Never having studied midwifery, I did not know what that meant. She explained that it was a child born without a brain, head not fully developed, 10 fingers and 10 toes etc.. but no head.
Because of not having any brain development, the child could not live, outside the womb. But our child lived for 10 minutes, and was baptised. When I requested to see the child, at delivery, I was told that it would be better, if I didn't.
Luckily, my husband was present, and he did see Catherine Anne, whom we named after, my sister and one of the Nurses present at the birth. But, I never saw, or held, our first child.
The pain of not seeing, or holding that child, still remains with me, to this day.
The hospital concerned, in their wisdom, and probably out of kindness, offered to have the child buried, with one of the geriatric patients, who had died that day, and so save us the grief of having to arrange for a burial.
It took many, many, visits to that maternity hospital, and many searches through records, and many visits to various graveyards, throughout our district, to find where my child, was buried.
It was some 30 years later, having gone through the 'Freedom of Information' route, that we found the probable resting place of our first child. And so we have a small plaque, as a gravestone was not allowed, due to the fact that there could be more than one other person buried in that grave. But we can, and do go, some 41 years later, and visit that grave.
I want to appeal to all people, and particularly those who are still undecided, to vote no in the coming referendum.
In an abortion, a life is terminated. But please remember that there are many people, who cannot have children, who would be only delighted to either adopt, or foster a child.
In this modern world, where we are all striving for perfection, we should remember, that nobody in this world, is perfect. We all have our own individual imperfections, our defects.
Thank you for taking the time to read this, but as a 74-year-old mother, with 5 wonderful children, and 7 grand children, I feel so, so strongly, that it is necessary to vote No in the coming referendum, and to keep the 8th Amendment in our constitution.
Maeve is not a member of any pro-life group and is writing in a personal capacity.
Posted in Misc and tagged The Eighth Amendment at 10:48 am on May 23, 2018 by Admin.
power move with such articulation, you win.
but you trusthe politicians of 1983?
And the bishops, let's not forget them. Not that I want to bash the bishops or anything but they were very interfering royalty back then.
That's such a copout, grow a pair!
According to UNICEF, there are 153 million orphans worldwide.
excellent point rach, and one that does not get enough airtime or traction.
But Maeve, that is how YOU feel. Other people might feel differently, can't you accept that?
Why do you want to impose what YOU feel on to others?
Vote Yes! Vote Yes Maeve, do not deny women control of what happens do them either conscious or not; in the way you were denied control of what happened to you.
How is Maeve imposing her views? She merely asked. And are you not imposing your views by saying vote yes??
Every Yes vote supports every abortion that will happen in Ireland.
@Andrew just pointed out to you every NO vote signals an absolute distrust of women to make the right choice for themselves.
you get to choose what to do with your body @newsjustin, it seems you would like me to also place my wife's rights into your hands. are you serious?
its a rhetorical question, because I know that's EXACTLY what you would like, no need to answer.
No Listrade. That's faulty logic.
Good! Thats the point. Women have been treated appallingly in Ireland for too long. They deserve the same rights and healthcare as the rest of Europe.
I think the European comparison should make some people stop and think. What has got lost in this debate is how extreme the 8th amendment actually is.
Adoption is not an alternative to abortion, it's an alternative to parenthood. Don't force me to carry a child, permanently physically alter my physiology and have to answer all of the questions along the way ("oh when are you expecting? you must be so excited" followed by "why are you giving up your child?! I could never do that"). There are millions of orphans in the world, plenty to go around for those who can't conceive and want a child, or those who can conceive but want to adopt anyway.
Not allowing a woman to see her own baby? Not telling her beforehand that the baby was FFA? Sneakily sedating her so she wouldn't be aware? All choices denied to the woman, all signs of the influence of the 8th. Please vote Yes.
This is what I got from that piece. This poor woman (and much of her generation) had very low expectations of maternity care, and was fine with being kept in the dark.
Times have changed. People expect more, women deserve better.
So sorry for your loss, but with respect, I should not be forced to carry a pregnancy I cant carry. Also, I don't feel I should be responsible for supplying others with children.
Well said Maeve. Abortion is the deliberate taking of human life. Voting for it, except in very grave circumstances, is a flagrant injustice to our fellow humans.
Forcing a raped woman to complete a pregnancy against her will is a flagrant injustice to a real sentient human.
For me, a 4-week-old foetus isn't a "fellow human".
its a 74 year old mother, writing her story and sharing her opinion, which she's fully entitled too, and most likely reading this,no need harangue her.
he's pointing out @newsjustin's logic is narrow & in my own opinion seriously flawed.
unless you'd prefer to live on planet justin & follow his preachings that is.
I think Cian is respectfully disagreeing with Newsjustin, who respectfully disagrees with him, and they are both being respectful of Maeve, who bravely offered up her story as part of the debate. If more of the debate was like this we'd be doing quite well, thank you.
I thought the same, Johnny, well said.
@johnny, this wasn't haranguing Maeve. She shared her sad story.
I was replying to newsjustin.
No but absolutely awful way she was treated most definitely is.
What about FFA (as she had) is not a very grave circumstance?
Again with the deflections. Nobody is voting *for* abortion, they are voting to remove an amendment, a faulty one at that, that was introduced into our constitution.
People who are voting Yes are doing so for choice, for compassion and for respect of a woman's right to decide what she feels is best. If, for whatever reason, she feels that she wants to terminate the pregnancy, she can do so in a safe and controlled environment here in Ireland. What might happen with legislation down the road is the domain of politicians and can be enacted or repealed much more swiftly than a constitutional amendment.
I have yet to meet someone who is voting *for* abortion, but do keep on, at the very least its a good look at the mentality of the No campaign.
In relation to the article, I feel for you Maeve, I really do and unlike people like Ronan Mullen, I don't feel the need to belittle your experience because it runs contrary to how I shall be voting. I don't feel the need to snigger or condescend to you, because you have had a tragic experience and I sympathize. But please, try to understand that this is not about trying to kill babies, its about allowing women the choice, a choice you had taken away from you by a tragic twist of fate, to decide what they want. I imagine you are firm in your views and I respect that, but I differ, but respectfully so. It is a very well written article, you may have missed your calling if writing is not what you have done until now as well!
How strange that these people do not realise that a Yes vote would still keep the option to not abort. It is as if a Yes vote will suddenly see no birth at all – mass killing for all. I am at a loss for words on the thought process in those people heads, no matter how sad this story is once again it is in no way a good argument for a No vote. If its compassion they are talking about and understanding then Yes is the only answer not restrictive in this corner stone issue of abortion rights.
It will see no birth for every single human that is aborted. Your argument seems to be that some babies will still be born, so what's the problem? The problem Is, individual human beings, the subject of individual choices for abortion, will be individually killed. Society will have choice, and we'll pat ourselves on the back for it, but individual human beings will have their lives ended.
It's really nice for you that as you have no possibility of personally being pregnant that you can be so absolute. Must be kind of a relief.
Justin – please do follow through on the conviction of your anti-abortion beliefs. Please start arresting pregnant women leaving Dublin Airport flying either to England or to Holland on the off-chance that they might be going there for abortions.
You anti-choicers are ok with abortions happening in England for Irish women but not here. You do not fully follow through with your convictions. Why not find a woman who has had a baby aborted and impose a 14 year jail sentence on her??? Because you know that the majority of Irish people would not stand for it.
I will never understand why you lot make it your life goal to fight the tide. Change is coming. It is progressive and it cannot be stopped. Yet you and LoveBoats, Breda O'Brien, John Waters, Davy Quinn and the Iona Institute etc. etc. will never stop fighting that tide as it laps onto our shores. Such a futile waste of energy yet you expend it – it's fascinating really.
The true measure of any person's commitment to human rights according to Pluto – willingness to go along with the tide.
Justin, it's none of your business. If you are so interested in the dignity of life, how come you spend your time here, instead of out on the streets helping the drug addicted and homeless?
Tycho, next you'll be telling me how pro-life people only care about people until they're born and then stop caring.
I won't, I'll just put the question to you again, maybe you'll answer this time?
But there we are again. I am going to say it Justin – the only 'human rights' you care about are those in the womb.
If this referendum passes on Friday, which please dear fupp it will, will you be out at every maternity hospital until your last breath trying to stop every single abortion in Ireland from happening ever? No of course you won't.
Serious question: Did the obstetrician arguing the No case last night not say that he proceeds with terminations sometimes even when there is a heartbeat?
Dr Trevor Hayes, a consultant obstetrician from Kilkenny. You can view it on the RTE player. He says it from around 6:15.
So here we have a doctor, on national television, arguing to retain the 8th while also stating that he performs abortions while a heart is still beating. I am not blaming for doing so but is he asking other obstetricians to also break the law just to save the 8th?
That is legal within the parameters of the 8th and the PLDPA 2013 as long there is a real and substantial risk of loss of the woman's life from a physical illness AND that risk can only be averted by carrying out an abortion.
So if she has sepsis and will die without treatment, an abortion is okay.
SOQ- that's not breaking the law!! If you think it is then you have failed to understand abortion law in Ireland. Doctors were never and have never been prevented from treating a woman whose life is at real risk. The foetal heartbeat is not a barrier to a doctor acting to save the life of the mother.
I thought this was we'll understood, obviously I was wrong. That doctor (from Kilkenny if I remember rightly), was explaining how he protects the life of women even if it means the unfortunate death of an unborn baby.
He's acting entirely appropriately and within the law. Frankly, misinformation like this SOQ is very unhelpful and misleading for pregnant women.
So we are back to the same question then, what is 'real risk'? Death's door?
Just wondering, how many women have actually died in such circumstances? Is there any stats? Likewise, how many women's health was damaged by lack of healthcare or do they all just go to England?
the difficulty (as I see it) is where the foetus has a heartbeat, but the woman's life isn't in danger – i.e. life Savita when she presented into hospital.
The foetus will not survive, the woman isn't *currently* in danger, but if she is left alone there is a chance that she will get sepsis – which could kill her.
In that window of time where the foetus is alive, but she doesn't have sepsis – can a doctor legally perform an abortion?
Using the Supreme Court interpretation it is serious and imminent. The report into the Savita cases quoted the doctor as saying that at that point sepsis was a theoretical risk. It was likely and probable, but not actual.
But under the PLDPA it requires two opinions (?) so if both agreed then maybe it would be legal?
Dunno. Way too grey an area. Which would be the whole point.
The doctors differ and the patient dies. Last night we had two doctors arguing very different things. They can't both be right?
They should and do know in advance which patient is at high risk of arriving at death's door before they can act. There is no flag which goes up to indicate so it is up to interpretation, or from the patient's perspective, luck.
Now anyone who believes in retain please come back and tell me what where I am wrong in this logic?
Essentialism failed with Darwin, quit pretending otherwise.
Even if you had been told of your baby's condition and abortion was available at the time, no one would force you to terminate your pregnancy. It should be your choice to continue with your pregnancy or not.
If the Yes vote is passed there will still be women making the choice to continue to term. As is their right.
A child with an FFA can't be adopted or fostered.
So sorry for the loss of your daughter Maeve, awful experience to go through. My partner and I have gone through a similar tragedy. We are voting No but not just because of our losses, because we believe life begins at conception. Vote No.
Why do you believe 'life begins at conception'? If you're being literal, that's not just demonstrably false, it's utter nonsense. If you're not being literal what DO you mean?
I know it sounds like I'm being pedantic but there are proper risks to putting things on poles carrying live.
Very sorry for your loss Maeve, and indeed it is awful that there was a cover-up by the hospital. You were denied control of your labour, your birthing experience and to see your own child. But your point at the end about adoption does not hold any weight to the rest of your story. Adoption is not an alternative to abortion and no one ever should have to sacrifice their well-being to be a service to those who are infertile. So hand back control to those who are pregnant and vote yes. If you please.
In the event of Repeal, Maeve, no one would force you to have an abortion if you wanted to bring your pregnancy to full term. Can you not respect the rights, needs and circumstances of other women to make decisions that differ from your own?
While I sympathise with Maeve on her experience, especially the way in which she was treated, I don't see the relevance to this referendum. The only similarity is that she had no say in her pregnancy which is exactly what a Yes vote will help change.
A very interesting read. Thank you for sharing Maeve. I'm so sorry for your loss, and for how you were treated. I can't imagine how awful it was to have buried the child you carried without ever getting to hold her.
However, I do agree with many of the other commenters here, and think that should the referendum pass, it will not infringe on your, or anyone else's, rights to carry their baby to term, even with a diagnosis of FFA. All it will allow is women the freedom to choose the best path for them.
It will also allow the ending of a human life Mildred. Lets not forget that.
But, as you well know after our many, many debates on the subject, that I believe that a woman's right to choose supercedes that of a 9 week old foetus. I won't deny that a life, or a potential one, is taken; I won't deny that a pregnancy is ended. But I won't stand in the way of another woman's choice – not in something of this magnitude, something as life altering as this.
The ending of a human life is already allowed. We are allowed to travel with the sole purpose being to end a human life.
What is not allowed now, is for it to happen in our own hospitals where people can be treated with dignity and respect. I am lucky I had two healthy pregnancies. If I had ever had to contend with an FFA or if either of my two beautiful daughters ever has to, I want the treatment to be at home where I/my daughters can be around family for all the support they need in this awful time. I want them to be able to bury their baby with dignity and not have to bring them home in a jiffy bag or a cool box.
will you feel lonely when all this is over on Friday?
Very very sorry for her loss and it does sound like she wasn't treated the best but with all due respect, what has this story got to do with the referendum. Given the timeline it surely would have occurred pre-1983?
If anything this story has made me even more certain that a Yes vote is the correct vote. Poor Maeve had all of the decisions during her pregnancy and birth taken away from her. The hospital decided for her that she shouldn't know the truth about her pregnancy. Instead of giving her the choice to hold and see her child as she wanted and the time to decide on what kind of burial she wanted for her daughter and to process what was happening she was sedated and had to spend years finding out where her baby was buried and she is only allowed a plaque at the place. What an awful story. The poor woman.
As heartbreaking as this story is I don't understand how a No vote would stop things like this happening. If the Yes vote wins on Friday mothers can still choose to carry their foetus to full term even if it has been diagnosed as having something like Anencephaly. While Maeve's story is obviously gut-wrenchingly sad it's very much her story and a YES or NO vote will not deny a mother the right to see her pregnancy through to the end. However, a YES vote will give a mother like Maeve more options, not less. A NO vote will force her to carry the foetus to full terms even though it lacks a brain (and one can therefore argue that after birth there will be no sentience whatsoever). Is it not disingenuous to posit these kinds of personal tragedies as a good reason to vote no?
Especially as one commentator pointed out that given her age this would have happened before the 8th was even inserted into the constitution..
There are so many personal tragedies being used to push a yes vote. It's good to see some balance.
This story is heartbreaking, and I am not surprised the terrible pain has stayed with this woman all this time. But it is really quite striking that every single stage of the trauma done to her was done by others (doctors) who disrespected her so much they took away all of her choices: not telling her about the FFA, drugging her to spare themselves, presumably, her distress, leaving it to the (less well paid) night nurse to break the truth to her, not giving her details of the burial.
Meave, can you not see this? They did not allow you to have any control. They showed very little compassion towards you, from what you say here. The Repeal movement is opposed to precisely this.
A Yes in the referendum won't mean compulsory abortions; it will mean dignified health care for those who need abortions, and an end to the kind of stigma which allowed doctors to treat women like this for so long.
I don't wish to diminish in any way the impact of the loss of her daughter had on Maeve, but, where to start? Firstly, it doesn't seem to bother Maeve that the truth of her (and her baby's condition was with-held from a grown woman – and a Nurse – according to this post. The medical profession, and her husband presumably, treated her like a small child. Other, more articulate posters than me, have already pointed out the millions of babies and small children who are crying out for the protection of a family… my last word – I personally know four women who have had abortions for various reasons. None of them expressed regret, only relief. I also know two women who, as young girls, were strongarmed into giving up their babies to the Nuns (who presumably received a healthy profit). Both of these women eventually married and had families, but the wound and the loss is still with them. Like myself, they are in their late sixties, but still cherish those lost babies.
She wants us to vote no because she was forced to carry a unviable baby to term, and others can't have babies?
I'd love to know how Maeve voted in the end. I hope the comments here gave her pause for thought.


text:
Free App Gives A Measure of Control Back To Patients Living With NETs and Carcinoid Syndrome
A free, easy-to-use app, Carcinoid NETs Health Storylines, is empowering patients to be proactive in tracking and staying on top of the many aspects of life with neuroendocrine tumors (NETs) and carcinoid syndrome. Says NETs patient and Self Care Ambassador Beth Leonard, the app "allows me to feel I have some semblance of control in a disease that's not in my control."
The app is a visually welcoming and intuitive one-stop place to store a patient's full range of information and resources, offering clearly identifiable tool boxes into which the patient logs everything from nutrition information and symptoms to medication reminders and appointment trackers. Patients can also access supportive resources such as Zebra Tales – stories of others with NETs – and healing music (including music written and performed by NET patients).
As patients load their information each day, the app creates a summary of their health called "My Storylines." As the data builds, the app can "talk back" to patients, providing reminders, for example, about when to take medications, which may help improve their ability to stick to a treatment plan or a routine. Over time, the way the app aggregates all the information into My Storylines helps patients see patterns and assess overall well-being.
An IT executive, Beth said, "I'm a data-driven person and I like that with the app I no longer have to guesstimate my answers to doctors' questions because I've been collecting my data all along. It's one thing to have the data in your head. It's a lot easier to have it on the app. With the app, I can give my doctors more accurate information about my body."
Her favorite features: "The Daily Mood, which helps me be cognizant and allows me to reflect on my mood and anxiety levels. The Stool Diary tool is also very easy to use. I use the journal. I use the Health Concerns tool to jot down questions I want to ask my doctors. And I use the routine builder – it gives me my water intake reminders."
As a Self Care Ambassador, working with the Carcinoid Cancer Foundation and Self Care Catalysts, the patient intelligence company that developed the platform for the app, Beth encourages other patients on their journeys. "I want to make a difference and have a positive impact on people." And indeed, she has. "One woman told me, 'You're the first person that gets me.' She told me what she was experiencing and I was able to say these are the questions to ask your doctor. These are the tests you need." One doctor told me, " 'You know more than I do.' He said I could be a professor at this point and teach other doctors."
Education, both of patients and health professionals, remains a barrier to effectively living with cancer and Beth sees the app as a tool that can help. "I encounter many people who don't have information about their cancers. Many patients are older and from a generation that believes that what the doctor says is the law. Or they are told misinformation by doctors who are not familiar with NETs. I had a doctor accuse me of having psychological problems. Don't let a doctor call you crazy; know your own body."
"This cancer is often misdiagnosed," says Beth. Doctors in training are taught a medical take on Occam's razor – "When you hear hoof beats, think horses, not zebras." In other words, think of common diseases when presented with common symptoms. "Occam's Razor doesn't apply to everyone," says Beth. "Sometimes you're the zebra."
Beth's message: "Take the time to use the app even if it's just to log in your mood that day." The data can put patients in a stronger position to make their case to doctors. "You have to be your own advocate," Beth emphasizes. The app can also help impose a little order in the universe. "You're not alone," says Beth. "You may feel alone, like nobody is listening, but you are not alone. Use the app because it can help you gain perspective and allow you to live your day-to-day life as normally as possible."
Access the on-line app here: https://healthstorylines.com/blog/?page_id=476. The mobile app is available through the Apple App Store and Google Play.
Read Beth Leonard's story on the Carcinoid Cancer Foundation's website at https://www.carcinoid.org/beth-leonard-living-neuroendocrine-cancer/. Visit her Facebook page, Living with Neuroendocrine Cancer, at https://www.facebook.com/pg/LIVEwithNETS.
Follow her on Twitter at @Guruofprocess and listen to her Real Health Stories podcast on iTunes or Google Play.
Categories: carcinoid syndrome
Tags: Beth Leonard, carcinoid cancer, Carcinoid NETs Health Storylines, carcinoid syndrome, health apps, Lynch Syndrome, neuroendocrine cancer, Self Care Catalysts
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text:
Home » » Rajiv Gandhi National Quality Awards 2010
Rajiv Gandhi National Quality Awards 2010
The Ministry of Consumer Affairs, Food and Public Distribution has announced the annual awards and commendation certificates for the seventeenth prestigious Rajiv Gandhi National Quality Awards for the year 2010.
The Best of All Awards has been won by Vikram Cement Works (A unit of Ultratech Cement Limited), Khor, Madhya Pradesh.
The other category award winners include Ashok Leyland Limited, Bhandara, Maharashtra (Large Scale Manufacturing Industry); Kudale Instruments Private Limited, Pune, Maharashtra (Small Scale Manufacturing Industry); and Chaitanya Hospital, Chandigarh, Punjab (Small Scale Service Industry).
In addition to these awards, ten organizations have been selected for commendation certificates under various categories.
The award winners and recipients of commendation certificates were selected from a total of 64 applicants from various sectors following vigorous evaluation by a group of qualified and trained professionals from different spheres of intellectual activity. Awards would be presented by Prof. K.V. Thomas, Minister for Consumer Affairs, Food and Public Distribution in a ceremony scheduled to be held later on.
The awards, given annually, were instituted by the Bureau of Indian Standards in the year 1991 with a view to encouraging Indian manufacturing and service organizations to strive for excellence and giving special recognition to those, who are considered to be the leaders of quality movement in India.


text:
Q: Is is possible to detect Undo/Redo in a Powerpoint Addin via C#? Is is possible to detect Undo/Redo events in a Powerpoint Addin via C#? Or is it possible to access what has happened or manipulate the Undo/Redo list?
I ask because I haven't seen anything that allows this, which makes me surprised, I was expecting it to be possible, so I'm asking mostly in the hope that I've missed something.
Any help would be much appreciated!

A: PPT doesn't expose the undo list, unfortunately, and there's no event you can trap to let you know when an undo/redo has taken place.
I suppose it'd be possible to implement your own undo stack but that seems like the kind of thing Stephen King would write novels about. ;-)

A: I too am looking for an event for Ctrl+Z/Undo. The idMso control for the Undo feature is a gallery so that's a dead end in terms of repurposing via a  in the customUI. There's no built in Application.OnUndo event and the only other thing I can think of is using WinAPIs to hook into the WindowProc procedure for PowerPoint to detect Ctrl+Z. I tried it briefly and can detect that key combination but I despise the instability this kind of thing causes, causing PowerPoint to potentially crash on some systems, and it doesn't address macOS. Here's the basis of the technique should someone want to refine it:
Option Explicit

Private Declare PtrSafe Function FindWindow Lib "user32" Alias "FindWindowA" (ByVal lpClassName As Any, ByVal lpWindowName As Any) As LongPtr
Private Declare PtrSafe Function GetActiveWindow Lib "user32" () As LongPtr
Private Declare PtrSafe Function RegisterHotKey Lib "user32" (ByVal hwnd As LongPtr, ByVal ID As Long, ByVal fsModifiers As Long, ByVal vk As Long) As Long
Private Declare PtrSafe Function UnregisterHotKey Lib "user32" (ByVal hwnd As LongPtr, ByVal ID As Long) As Long

Private Declare PtrSafe Function CallWindowProc Lib "user32" Alias "CallWindowProcA" ( _
                                        ByVal lpPrevWndFunc As LongPtr, _
                                        ByVal hwnd As LongPtr, _
                                        ByVal MSG As Long, _
                                        ByVal wParam As LongPtr, _
                                        ByVal lParam As LongPtr) As LongPtr
Public hWndPPT As LongPtr

Public Type POINTAPI
  x As Long
  y As Long
End Type

Public Type MSG
    hwnd As LongPtr
    Message As Long
    wParam As LongPtr
    lParam As LongPtr
    time As Long
    PT As POINTAPI
End Type

#If Win64 Then
   Private Declare PtrSafe Function SetWindowLongPtr Lib "user32" Alias "SetWindowLongPtrA" (ByVal hwnd As LongPtr, ByVal nIndex As Long, ByVal dwNewLong As LongPtr) As LongPtr
#Else
   Private Declare PtrSafe Function SetWindowLongPtr Lib "user32" Alias "SetWindowLongA" (ByVal hwnd As LongPtr, ByVal nIndex As Long, ByVal dwNewLong As LongPtr) As LongPtr
#End If

Private Const GWL_WNDPROC As Long = -4& ' Sets a new address for the window procedure

Private PrevWndFunc As LongPtr          ' Pointer to the initial window proc

Private Const WM_HOTKEY = &H312&        ' HotKey message

Private Const MOD_Control = 2           ' Either CTRL key

Public Sub RegisterCtrlZ()

    Dim returnedVal

    hWndPPT = GetPPThWnd

    returnedVal = RegisterHotKey(hwnd:=hWndPPT, ID:=1, fsModifiers:=MOD_Control, vk:=vbKeyZ)
    Debug.Print "RegisterHotKey returned " & returnedVal

    ' Set the window callback procedure
    PrevWndFunc = SetWindowLongPtr(hWndPPT, GWL_WNDPROC, AddressOf WindowProc)

End Sub

Public Sub UnregisterCtrlZ()

    Dim returnedVal

    hWndPPT = GetPPThWnd

    returnedVal = UnregisterHotKey(hwnd:=hWndPPT, ID:=1)
    Debug.Print "UnregisterHotKey returned " & returnedVal

    PrevWndFunc = SetWindowLongPtr(hWndPPT, GWL_WNDPROC, PrevWndFunc)

End Sub

Public Function WindowProc(ByVal hwnd As LongPtr, ByVal uMsg As Long, ByVal wParam As LongPtr, ByVal lParam As LongPtr) As LongPtr

    ' Check if a hotkey and the main PPT window is the active window
    If uMsg = WM_HOTKEY And GetActiveWindow = hWndPPT Then
        Debug.Print "Hotkey " & wParam & " event (Ctrl+Z)"
    End If

    ' Call the next window proc
    WindowProc = CallWindowProc(PrevWndFunc, hwnd, uMsg, wParam, lParam)

End Function

' Get the handle for the PowerPoint window
Public Function GetPPThWnd() As LongPtr

    Select Case Val(Application.Version)
        Case 8
            GetPPThWnd = FindWindow("PP97FrameClass", 0&)
        Case 9 To 12
            GetPPThWnd = FindWindow("PP" & Val(Application.Version) & "FrameClass", 0&)
        Case Else
            GetPPThWnd = FindWindow("PPTFrameClass", vbNullString)
    End Select

End Function

redpajama_set_name: RedPajamaStackExchange


text:
Q: How can I change from a sed to Perl statement in command line? I need to search a phrase in multi files and display the results on the screen.
grep "EMS" SCALE_*
| sed -e "s/SCALE_//" -e
"s/_main_.*log:/ /"

Since I am not get familiar with sed, I change it to Perl for convenient use.
grep "EMS" SCALE_*
| perl -e "s/SCALE_//" -e
"s/_main_.*log:/ /"

or
grep "EMS" SCALE_*
| perl -e "s/SCALE_//; s/_main_.*log:/ /"

However , the last one is compiled but returns nothing on the command line.
Any suggestion for modifying my code.
Great thanks!

A: To use perlin the style of sed you should try the -pflag:
perl -p -e "s/SCALE_//;" -e "s/_main_.*log:/ /;"

From the explanation in perlrun:

-p

causes Perl to assume the following loop around your program, which makes it iterate over filename arguments somewhat like sed:
LINE:
  while (<>) {
    ...             # your program goes here
  } continue {
    print or die "-p destination: $!\n";
  }

A: You're not looping over the input lines with perl. Check out -p or -n in the perlrun man page.

A: if you want to use Perl, then try this entirely in Perl
while ( <> ){
    chomp;
    if ( $_ =~ /EMS/ ){
        s/SCALE_//g;
        s/main.*log://g;
        print $_."\n";
    }
}

on the command line
$ perl perl.pl SCALE_*

or this
$ perl -ne 'if (/EMS/){ s/SCALE_//g;s/main.*log://g; print $_} ;' SCALE_*


Moin, moin (as we say in Hamburg)! You are on the website of the student representatives of Department E, a.k.a. the FSR ET/IT. If you study Microelectronics and Microsystems, Information and Communication Systems, Electrical Engineering, Computer Science, Computer Engineering or Technomathematics, or if you're interested in any of these courses of study, you're at the right place. Moin, moin (as we say in Hamburg)! You are on the website of the student representatives of Department E, a.k.a. the FSR ET/IT. If you study Microelectronics and Microsystems, Information and Communication Systems, Electrical Engineering, Computer Science, Computer Engineering or Technomathematics, or if you're interested in any of these courses of study, you're at the right place.
- on 13.04. and 14.04..
- We apologize for any inconvenience.