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XB-ART-14012
Dev Biol 1998 Nov 01;2031:36-48. doi: 10.1006/dbio.1998.9028.
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Programmed cell death during Xenopus development: a spatio-temporal analysis.
Hensey C , Gautier J .
Programmed cell death (PCD) is an integral part of many developmental processes. In vertebrates little is yet known on the patterns of PCD and its role during the early phases of development, when embryonic tissue layers migrate and pattern formation takes place. We describe the spatio-temporal patterns of cell death during early Xenopus development, from fertilization to the tadpole stage (stage 35/36). Cell death was analyzed by a whole-mount in situ DNA end-labeling technique (the TUNEL protocol), as well as by serial sections of paraffin-embedded TUNEL-stained embryos. The first cell death was detected during gastrulation, and as development progressed followed highly dynamic and reproducible patterns, strongly suggesting it is an important component of development at these stages. The detection of PCD during neural induction, neural plate patterning, and later during the development of the nervous system highlights the role of PCD throughout neurogenesis. Additionally, high levels of cell death were detected in the developing tail and sensory organs. This is the first detailed description of PCD throughout early development of a vertebrate, and provides the basis for further studies on its role in the patterning and morphogenesis of the embryo.
PubMed ID: 9806771
Article link: Dev Biol
Species referenced: Xenopus laevis
Genes referenced: dnah5 dnai1 pcbd1
Article Images: [+] show captions
FIG. 1. Whole-mount TUNEL staining reveals dying cells in gastrulation-stage embryos. (A) Stage 10.5, vegetal view, no TUNEL staining was detected in this embryo. (B) Stage 10.5, lateral view, a small patch of TUNEL staining is evident in the equatorial region of the embryo. (C) Stage 10.5, vegetal view, hundreds of TUNEL-positive nuclei were evident in the circumblastoporal region. (D) Stage 10.5, lateral view, TUNEL-stained nuclei covered the surface of the embryo except for the blastopore. (E) Stage 11.5, vegetal view, a patch of TUNEL staining in the equatorial region extends to the edge of the blastopore. (F) Stage 11.5, lateral view, two bilaterally symmetrical patches of TUNEL staining border the blastopore. (G) Stage 11.5, animal view, TUNEL staining was detected in the animal pole and extended vegetally to the edge of the blastopore. (H) Stage 11.5, lateral view, a partially exogastrulating embryo showing an accumulation of TUNEL-positive nuclei in the blastopore (arrowhead). (I) Stage 12.5, animal view (left), lateral view (right). A dorsal median stripe of TUNEL-stained nuclei extended from the blastopore. (J) Stage 12.5, animal view (left), lateral view (right). TUNEL-stained nuclei were detected across the dorsal side of the embryo. Throughout gastrulation TUNEL staining was never detected in the blastopore, indicated by the dotted red line. The embryos shown are representative of the TUNEL staining observed following analysis of 237 embryos of which 67% were stained. Embryos with more than 5 TUNEL-stained nuclei were considered TUNEL positive.
FIG. 2. Programmed cell death as detected by whole-mount TUNEL staining at the neural plate stage. (A) Stage 13, dorsal (top) and lateral (bottom) view. The dorsal side of the embryo is TUNEL stained with a band of staining broadening toward the anterior end of the embryo, delineating the neural plate. (B) Stage 13, dorsal (top) and lateral (bottom) view. Two broad bands of staining extend laterally from the blastopore slit. (C) Stage 13, dorsal (top) and lateral (bottom) view. A broad medial stripe of staining was detected on the dorsal side. (D) Stage 14, lateral view, anterior is left, no TUNEL staining was detected. (E) Stage 15, lateral view, anterior is left. Intense TUNEL staining was detected in the anteriormost portion of the embryo. Light staining was evident posteriorly. (F) Stage 14, dorsal (top) and lateral (bottom) view, anterior is left. A semicircular band of staining in the anteriormost portion of the embryo, corresponding to the anterolateral edge of the neural plate. (G) Stage 15, end on anterior view (top), lateral view (bottom), anterior is left. TUNEL staining formed a horseshoe-shaped band of staining in a more anteroventral position than stage 14. The embryos shown are representative of the staining observed following staining of 58 stage 13 embryos of which 67% were TUNEL positive, and 37 stage 14/15 embryos of which 52% were TUNEL positive. Embryos with more than 5 TUNEL-stained nuclei were considered TUNEL positive.
FIG. 3. Programmed cell death as detected by whole-mount TUNEL staining at the neural fold stage. A, B, and C, stage 17. Dorsal, lateral, and end-on anterior views are shown for each embryo (left to right). (A) TUNEL staining was detected in the anteriormost portion of the embryo with a light scattering of staining along the length of the neural fold. (B) Strong TUNEL staining in the anteriormost portion of the embryo, corresponding to the optic placodes (arrowhead). Staining extends from these placodes along the neural fold. (C) Strongest staining was in the anterior embryo with patches of TUNEL staining corresponding to the optic (arrowhead), and olfactory (arrow) placodes, and developing brain. Dying cells were found in defined stripes on each side of the dorsal midline corresponding to the primary sensory neurons. A scattering of dying cells was detected throughout the neural fold. Lines 1 and 2 mark the approximate location of transverse sections shown in Figs. 7B and 7C, respectively. The cell death patterns are representative of the staining observed following staining of 33 embryos of which 64% were TUNEL positive. Embryos with more than 5 TUNEL-stained nuclei were considered TUNEL positive.
FIG. 4. Programmed cell death as detected by whole-mount TUNEL staining at the late neural stage. Each panel shows a lateral (top), and a dorsal (bottom) view. (A) Stage 18, TUNEL staining in the anteriormost portion of the developing brain. A clear asymmetry is present. (B) Stage 18, TUNEL staining in the posterior of the embryo, along the neural fold. (C) Stage 18, bilaterally symmetrical staining in the anterior developing brain, and faint staining in the posterior of the embryo. (D) Stage 23, bilaterally symmetrical diffuse staining in the developing head possibly corresponding to migrating neural crest cells. (E) Stage 23, diffuse staining in the developing head, showing a distinct right–left asymmetry. (F) Stage 25, diffuse TUNEL staining throughout the head and tailbud. The staining shown is representative of the programmed cell death seen following staining of 89 embryos of which 98% were TUNEL positive. Embryos with more than 5 TUNEL-stained nuclei were considered TUNEL positive.
FIG. 5. Programmed cell death as detected by whole-mount TUNEL staining during stages 26–28. Each panel shows a lateral view (left), and a dorsal view (right). (A) Stage 26, the embryo looks younger in the lateral view due to curvature. TUNEL staining is evident in the ventral forebrain and midbrain in addition to the eye vesicle. Staining was also evident in the posterior half of the spinal cord (arrowheads), and in the tailbud. Line indicates the approximate location of the transverse section shown in figure 7D. (B) Stage 26, staining in the midbrain, posterior spinal cord and tailbud. (C) Stages 27–28, staining in the midbrain, hindbrain, and eye vesicles. (D) Stages 27–28, bilaterally symmetrical staining in the midbrain. The patterns of cell death shown are representative of the cell death detected following staining of 36 embryos, all of which were TUNEL positive. Embryos with more than 5 TUNEL-stained nuclei were considered TUNEL positive.
FIG. 6. PCD as detected by whole-mount TUNEL staining during stages 29–35. Each panel shows a lateral (top), and dorsal view (bottom). (A) Bilaterally symmetrical TUNEL staining is detected in the fore- and midbrain; lighter staining is detected in the eye vesicle. Line indicates the approximate location of a sagital section shown in Fig. 7F. (B) TUNEL staining is detected in the brain, eye vesicles, the posterior half of the spinal cord, and the elongating tail. (C) Dying cells were detected in the brain and developing eye. (D) TUNEL staining in the rhombencephalon, the outer ring of the eye vesicle the branchial arches (arrowheads), and the otic vesicle. Staining was also evident along the length of the spinal cord and in the tail tip. The staining is representative of the patterns seen following staining of 92 embryos of which 99% were TUNEL stained. Embryos with more than 5 TUNEL-stained nuclei were considered TUNEL positive.
FIG. 7. Sections of TUNEL-stained embryos from stages 13 to 35. (A) Stage 13, arrowhead indicates TUNEL staining in the presumptive neuroectoderm. (B) Stage 17, transverse section (1) indicated in Fig. 3C, shows TUNEL staining in circular patches which correspond to the developing brain and sensory placodes. (C) Stage 17, a transverse section (2) indicated in Fig. 3C, shows TUNEL staining in the region of the neural crest. (D) Stage 26, a transverse section indicated in Fig. 5A, TUNEL staining was detected in both sides of the spinal cord giving rise to two bilaterally symmetrical dorsal stripes, Fig. 5A (arrowheads). (E) Stage 31/32, a transverse section through the head as indicated in Fig. 6B shows TUNEL staining in the brain and optic stalk. Most intense staining is evident in the ventral diencephlon. (F) Stage 29/30, a sagital section of the embryo indicated in Fig. 6A, shows TUNEL staining in the mesencephalon, diencephalon, and telencephalon regions of the brain.


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It is a mandatory requirement that a signed copyright letter also be submitted along with the manuscript by the author to whom correspondence is to be addressed, delineating the scope of the submitted article declaring the potential competing interests, acknowledging contributions from authors and funding agencies, and certifying that the paper is prepared according to the 'Instructions for Authors'. All inconsistencies in the text and in the reference section, and any typographical errors must be carefully checked and corrected before the submission of the manuscript. The article contains no such material or information that may be unlawful, defamatory, fabricated, plagiarized, or which would, if published, in any way whatsoever, violate the terms and conditions as laid down in the agreement. The authors acknowledge that the publishers have the legal right to take appropriate action against the authors for any such violation of the terms and conditions as laid down in the agreement. Download the Copyright letter.
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You are in : All News > Beneo Inc. president flags long-term COVID-19 effects on health-conscious consumers
Beneo Inc. president flags long-term COVID-19 effects on health-conscious consumers
20 Jul 2020 --- Beneo is preparing for the rise of health-conscious consumers to continue in the wake of COVID-19, predicting that this will play a key role in future product development. Jon Peters, President of Beneo Inc., tells NutritionInsight how manufacturers are set to find new ways to strengthen existing products and tap into the rising demand for health and naturality. This follows the company's attendance at SHIFT20, where its virtual stand revolved around the theme "Healthier Carbs, Healthier Living."
"At this year's virtual IFT event, Beneo highlighted how alternative carbs, prebiotic fibers, plant-based proteins and rice ingredients can be used to improve a product's nutritional profile, as well as its taste and texture. This results in foods and beverages which support a more balanced diet, leading to a healthier long-term lifestyle," explains Peters.
He is supportive of the virtual meetings and events, noting that they allow for connection with international industry professionals. "This allows us to extend our dialogue at the event to an engaged global audience, at a time when the limiting factors of international travel, such as travel time and cost restrictions, would not have allowed for this to take place in person."
Peters is also "certain" that the rise of virtual formats, including live interactions for discussion forums, creation of videos or other "interactive journeys," will lead to a lasting change in the working environment. However, he flags that personal contacts will continue to play an important role in the future. Additionally, haptic experiences like trying out product samples will remain an important factor of trade shows in the industry.
Addressing the larger changes set to result from the pandemic, Peters notes that there is likely to be a continued interest in nutrition for disease prevention. "The impact of the coronavirus on the health and wellness market will be long-term and wide-ranging. This means that the industry will have a lot of opportunities to help consumers improve their diets," he details.
He also notes that prevention is paramount. "Not only are people looking at reinforcing their immune system, but the COVID-19 crisis has demonstrated more clearly than ever before that there is a direct link between diet and overall health and well-being." Specific areas to watch are products with functional benefits, such as digestive or immune support, or products that can help with dietary-related diseases.
Beneo believes that replacing sugar with maltodextrin is nothing more than a "label cosmetic."Addressing blood sugar management
Front and center at SHIFT20 was Beneo's Palatinose, an isomaltulose touted as meeting consumer demands for alternative carbohydrates. In contrast to more commonly known sugars like sucrose, Palatinose is metabolized in a more gradual way. According to Peters, it helps keep blood sugar levels in balance and thus also the insulin release under control. He also pegs blood sugar management as being an area set for significant growth over the next 12 months.
"Consumers have learned from the COVID-19 crisis that the progression of the infection has been more severe in obese people, those with constantly high blood sugar levels and some other diseases. This presents an opportunity for manufacturers to develop products that help consumers control their blood sugar levels by using the right ingredients," he details.
Ingredient lists often show that sugar is replaced with maltodextrin. However, Beneo believes that this type of replacement is nothing more than a "label cosmetic" and can potentially mislead the consumer. Peters details that maltodextrin can lead to a high release of insulin into the body, which facilitates the storage of fat. "In the long run, this may lead to weight gain, insulin resistance and eventually, diabetes. For Beneo, it is crucial to offer solutions for sugar replacement to consumers that support a healthy lifestyle in a sustainable way."
A more informed consumer
Today's consumers have access to a wealth of information at their fingertips and are much more aware of the holistic effect their diet has on their overall health and well-being. Peters explains that instead of relying solely on the brand communications they see adorning supermarket shelves, many people are actively seeking to know more about the products they are consuming. This to aid them in making more ethical and healthier choices, which has also led to the rise of the clean label trend.
"This trend has also been accelerated by the COVID-19 pandemic, leading to a surge in demand for more sustainable and organic foods. Now, more than ever before, consumers want to make ethical and healthier choices. With one in two consumers looking at the ingredients list on new products before buying, what goes into our food and drink has never been so important," he explains.
Beneo has been working in partnership with producers, exploring these areas further to help them meet the increasing consumer demand for organic food and drink products. This has led to Beneo recently expanding its chicory root fiber and rice starch ingredient portfolio with two new organic solutions. The launch of the new additions, comprising an organic waxy rice starch and organic chicory root fiber, paves the way for Beneo to strengthen its position on the market.
An emphasis on gut health Today's consumers have access to a wealth of information at their fingertips.
Also on Beneo's radar is the rising demand for ingredients to boost digestive health. As understanding of digestive health grows, more consumers are taking an interest in the intrinsic link between their gut and their overall health and well-being. In particular, they are beginning to understand that a balanced microbiome can positively affect the entire body, notes Peters.
"The inner defense system is our invisible personal bodyguard and we should look after it well to stay safe and healthy – a fact that needs to be kept in mind beyond the challenging times faced through the pandemic. The inner defense system includes the immune system, a good functioning gut barrier and a balanced microbiota. All of these are linked together and situated in the colon," he states.
He continues that prebiotics promote the development of good bacteria such as Bifidobacteria, and they strengthen the inner defense system to help it fight pathogens. "Chicory root fibers inulin and oligofructose are two of three proven prebiotics and the only plant-based prebiotics. A comprehensive body of high-quality studies confirms their health benefits."
"With digestive health and the microbiome playing such an important role in strengthening the inner defense system, there has never been a better time for F&B producers to incorporate prebiotics into products to help improve the daily nutrition of consumers," concludes Peters.
Gut health was a common theme at SHIFT20, with CometBio also highlighting its clinical trial, which evaluated the gastrointestinal tolerability and prebiotic effects of arabinoxylan. Meanwhile, a presentation from companies including Innova Market Insights and Ingredion explored the rise of the keto trend and the R&D challenges it faces.
By Katherine Durrell, with additional reporting by Elizabeth Green
Beneo Palatinose SHIFT20 IFT Coronavirus COVID-19 Gut Health Clean Label Organic Obesity Blood Sugar Management
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Robocide is a tower defense game with robotic characters. You get to know what kind of game is this you will love this game. it has intense gameplay, super smooth strategic tower defense play with good graphics. graphics are not that 3D designed but one you get the good game which has good gameplay then you do not need anything more. just the gameplay will do its best to feel your hunger for the game. its me RG doing timepass in reviewing this game and let see what it is about. robocide is a freemium game available free in the play store. i am playing this game in my pc's bluestack software and its playing quite well. gameplay looks epic and the graphics are good as well. in stage you have two towers in the level one is for you which you have to defend and the other one is enemies tower which you have to destroy. once you destroy that tower you win. to destroy the tower your tower generates little robots over time when time finished each tower generates good amount of robots. and with simple one touch control you can decide where these robots go. tap on the upcoming enemies so they fight with them. once you have finishes the enemies tap again on enemy tower to attack the tower. once health goes down to 0 its over. then go to the next level. looks easy. each level provides you rewards which you can upgrade your bots or buy new one but wait lady we have tons of money already so keep your rewards for yourself and chill. well its a unity engine game and its pretty easy to crack. someday ill show you how to do that unlimited money thing. but today enjoy this game.its pretty good. using Robocide MOD APK 1.16.3 you will have unlimited money.
The Robocide Hades update is here!
– More Starmap levels added – can you get to the end?!
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Pericopes+1
Last Show: Tuesday 1 st May 2018
Umbria Jazz Prize and Italian Top Jazz winners Pericopes teamed up with NYC-based drummer Nick Wight in 2014 to create Pericopes+1, "a cleverly unorthodox trio" according to Italian magazine Musica Jazz. Don't miss this special London show to launch their 2018 release Legacy (Auand) before heading north to headline the Ribble Valley Jazz Festival! Comprised of Emiliano Vernizzi, Alessandro Sgobbio and Nick Wight, Pericopes+1 earned public praise by jazz heavyweights Dave Liebman and Enrico Rava. The fresh, close-knit transatlantic trio is reshaping what it means to be a modern and original.
"The trio's most impressive feat is that its ambitions don't inhibit the music's accessibility" - Jazziz (USA)
"Wonderful music with very diverse repertoire, played flawlessly" - Dave Liebman (Saxophone Legend)
Formed in 2007 as a jazz duo project in Italy, Pericopes has an affinity for melodic themes and unique compositional structures. They released three original albums and won several awards before collaborating with American drummer Nick Wight, forming Pericopes+1. With a fresh approach blending experimental, folk, post-rock and avant garde elements from European and American traditions, they released These Human Beings (Alfa) in 2015, earning widespread critical acclaim and prestigious concert invitations throughout Europe, the U.K. and USA. Pericopes+1 is on an extensive set of spring tours promoting their newest 2018 album, Legacy (Auand).


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Global Watchdog Gives Pakistan Until February To Step Up Action Against Terror Funding
FATF (the Financial Action Task Force) President Xiangmin Liu attends a news conference after a plenary session at the OECD Headquarters in Paris on October 18.
A global money-laundering watchdog has given Pakistan until February to step up its operations to combat terrorism financing in accordance with an internationally agreed action plan or face actions against it.
"The FATF strongly urges Pakistan to swiftly complete its full action plan by February 2020," the Paris-based Financial Action Task Force said in a statement at the end of a five-day meeting on October 18.
"Otherwise, should significant and sustainable progress not be made across the full range of its action plan by the next Plenary, the FATF will take action."
Last year, the FATF placed Pakistan on its terrorism-financing "gray" monitoring list last year to pressure Islamabad to halt alleged support for militant groups.
The FATF, which comprises 35 member states and two regional organizations, discourages banks and global investors from lending money to a country put on its gray list.
The move followed a push by the United States and European allies to get Islamabad to close financing loopholes to terrorist groups.
Pakistan has also been under pressure to stop offering a safe haven to militants blamed for attacks in Afghanistan.
Islamabad has denied the charges, insisting that it is clamping down on extremist groups and their financing.
But it also said it made a "high-level" commitment to work with international authorities to tighten regulations and follow an action plan to curb money-laundering and terror financing.
Pakistan has blamed its neighbor and bitter nuclear rival India for lobbying to blacklist it and has looked to friendly nations such as China, Turkey, and Malaysia for support.
Reuters reported that during a recent visit to Beijing, Pakistan's civil and military leadership was assured by Chinese leaders that Islamabad would not be placed on the task force's blacklist.
"God willing, we're trying that we get out of this gray-list as soon as possible, and I think you should believe that a comprehensive effort is being put in place," Pakistani Finance Minister Abdul Hafeez Shaikh told a news conference.
"We have done a lot to remove anomalies in our system. We hope the body will remove us from the watch list," he added.
With reporting by Reuters and dpa


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Bargain Finder 8: AccurateShooter's Deals of the Week
At the request of our readers, we have launched a "Deals of the Week" feature. If this proves popular, we'll try to run this every Monday. Here are some of the best deals on hardware, reloading components, and shooting accessories. Be aware that sale prices are subject to change, and once clearance inventory is sold, it's gone for good. You snooze you lose.
1. Midsouth and Powder Valley — Hodgdon Varget and H4350
Two of the most sought-after (and hard-to-find) powders are now available, at least in one-pound versions. Midsouth Shooters Supply has Hodgdon Varget in one-pound containers for $23.30/pound, while Powder Valley has Hodgdon H4350 in one-pound containers for $23.25/pound. Act quickly — supplies are limited. NOTE: If these sources run out, Precision Reloading has both Varget AND H4350, priced at $29.49 for a one-pound container.
11/10/2015 Update: Midsouth has Sold Out of Varget. Precision Reloading still has it.
2. Grafs.com — Nikon Laser Rangefinder Scope
Now can get a quality Nikon riflescope with a built-in Laser Rangefinder for no more than you'd pay for a Rangefinder by itself. That's right, Nikon's advanced 2.5-10x40mm M-223 LASER IRT combines a Laser Rangefinder with a full-featured scope. This is good set-up for hunting — you don't have to carry a separate LRF. This unit offers "one-touch" activation with range values that display for 12 seconds. That makes it easy to hold your rifle with both hands while scanning.
3. Natchez Shooters Supply — 325 Rounds .22 LR Ammo, $20.99
Now we're talking — this is the kind of pricing on bulk rimfire ammo we used to see in the "good old days". Act quickly, this Federal .22 LR Ammo deal won't last long. Also, seller Natchez has a purchase limit: "Due to limited supplies and high demand this item has a 2-piece maximum order quantity per customer, per every 1 day." So you may order two boxes per day, which will total 650 rounds. The bullets are 40 grains, solid lead.
4. CDNN Sports — Walther PK380, $339.99
Bond… James Bond. If 007 were to pack a modern-day equivalent of his Walther PPK, it would be this slim new PK380 in .380 ACP. Weighing just 19.4 ounces, the slim PK380 is easy to carry. The grip is very comfortable even for small hands, and the slide is easy to operate, making this a good choice for the ladies. The PK380 has an ambidextrous manual safety and is hammer-fired.
5. Bullets.com — New Heavy, Cast-Iron 50 BMG Front Rest
If you're shooting a Fifty, you need lots of stability. Now there's a big, heavy front rest designed expressly for the big .50 Caliber rifles. This new, 20″-wide cast iron rest weighs a whopping 24 pounds. Pin-to-Pin footprint is 18.9″ providing outstanding stability and resistance to rocking. The large top accepts front bags up to 8-3/4″ x 3″ (bag not included). Designed to be used either on the bench or on the ground, the new Bald Eagle Big Fifty Cast Iron Rest (Model BE1161) is available for $375.00 as an introductory special.
6. Creedmoor Sports — $50 Off Hardback Shooting Coats
As an end-of-year special, Creedmoor Sports has knocked $50.00 off its famous Hardback shooting coats. Choose from all-leather, leather + Cordura nylon, or all-Cordura. We personally like the Combo coat that uses leather in the arms/shoulders with nylon in the front. This saves weight and is a bit more comfortable in summer heat.
7. Brownells.com — Hornady Ultrasonic Cleaning Machine, $49.99
Yes, you can get a name-brand Ultrasonic cleaning machine for under fifty bucks. This Hornady Lock-N-Load Sonic Cleaner, which sells elsewhere for $75-$85, is available at Brownells.com this week for just $49.99. This cleaning machine holds up to 200 .223 Remington cases, or 100 .308 Winchester cases.
8. Amazon.com — Manfrotto 410 3-Axis Geared Head
Once you've used a geared head for your spotting scope, you'll never want to go back to standard tripod controls. The Manfrotto 410 Junior Geared Head delivers precise 3-Axis control: 360° of pan (traverse), +90° to -30° of front tilt (elevation), and +90° to -30° of lateral tilt. When spotting, this makes it much easier to traverse from one target to another — you can move horizontally with no vertical movement. AccurateShooter's editors use this model 410, which features a quick-release plate. This is a very good deal. This same Manfrotto 410 Geared head sells elsewhere for $270.00 or more.
Bargain Finder 25: AccurateShooter's Deals of the Week
Monte's Manfrotto — F-Class Spotting Scope Stand
Black Friday Bargains on Top-Rated Hardware
Tripod Gizmos make Spotting Easier, More Precise
High Demand Powders — Where You Can Find Them
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Tags: .22 LR Ammo, Bullets.com, Creedmoor Sports, Front Rest, Grafs.com, Hardback Coat, LRF, Midsouth, Natchez, Rangefinder
Permalink Bullets, Brass, Ammo, Hot Deals
4 Responses to "Bargain Finder 8: AccurateShooter's Deals of the Week"
Yet another fine list of bargains! Although they can keep the varget, to many other powders work as well or better.
HODVARG-01 * HODGDON VARGET – 1LB. Out of Stock
No Backorder $23.25
HODVARG-08 * HODGDON VARGET – 8 LBS. Out of Stock
No Backorder $165.00
out at powder valley too I'm shocked.
Editor: Powder Valley had H4350, not Varget, when we posted the story.
Midsouth had it yesterday in stock. Limit 30. Went fast.
Kurz says:
The Walther PK380 is $285 at Widener's
The .22LR ammo has a shipping cost of $16.11 for one box.
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The Charge of the Light Brigade, 1968
Filmed in 1968 at the height of the counterculture movement, as the escalation of the Cold War and a seemingly interminable Vietnam War pervaded the collective consciousness of the entire international community, Tony Richardson's sumptuous, confrontational, and acutely rendered magnum opus, The Charge of the Light Brigade is a scathing indictment, not only of the arrogance and madness of war, but more importantly, of the myopic insularity of class and privilege intrinsic in the monolithic culture of the people behind the powerful institutions who wage these wars. A chronicle of the British involvement – or more appropriately, insinuation – into the Crimean War between Russia and the Ottoman Empire that led to the ill-fated uphill charge of the Light Brigade cavalry against a waiting, well-armed Russian artillery unit in the valley of Balaclava, the film follows the plights of the battle's key historic figures in the lead up to the confrontation and its inevitable aftermath: Lord Raglan (John Gielgud), the elderly, muddle-headed, incompetent commander and field strategist whose career had been defined by his experience in Waterloo and continues to regard each enemy encounter as a form of indirect engagement against France (despite both countries being on the side of the Ottoman Empire in the war); Lord Cardigan (Trevor Howard), the bombastic, cocksure Major-General who commanded the Light Brigade under reluctant orders from his superior, and estranged brother-in-law, Lord Lucan (Harry Andrews); Captain Nolan (David Hemmings), the enigmatic, battle-anxious, cavalry officer who would personally deliver Lord Raglan's fateful orders that would lead to the charge. Beyond the bracing contemporaneity implicit in Richardson's provocative depiction of the mid nineteenth century war on 1960s British society – and, by extension, its worthy invitation for renewed, critical evaluation in the inextricable mire of post 9/11 global politics – what makes the film continually relevant is its uncompromising attack on entrenched, Victorian-era sensibilities of colonialism and political interference (wryly illustrated through woodcut animation sequences that prefigure Monty Python interstitial animation and Raoul Servais' antiwar, social interrogation short film, To Speak or Not to Speak) under inflated, narcissistic ideals of a society's moral role as the world's police against tyranny and aggression, and its divine role as emissaries of (Christian) enlightenment. It is this delusive posture of self-anointed moral superiority and cultural imperialism that is inevitably shattered in the film's ambiguous final sequence, as the architects of the battlefield deflect personal accountability over the tragic blunder against the sight of bloodied, surviving soldiers returning to camp ready to fight again – an image, not of human enlightenment, but of vainglorious, self-perpetuated folly.
© Acquarello 2007. All rights reserved.
Categories: Directors, Film Festivals and Retrospectives, National Cinema
Tags: British Cinema, Tony Richardson, Woodfall
Tom Jones, 1963 «» Battle in Heaven, 2005
The Queen, 2006
Kes, 1969
Vera Drake, 2004
Secrets and Lies, 1996
Naked, 1993


UPDATE: It will state on their FB Page that it's a $2/2 Coupon but check your printable as you might find it's a $2 Off 1 instead! Thanks for the heads up, Rena!!
You can grab a higher-value $2/2 Carnation Breakfast Essentials Coupon on their Facebook Page.
You should be able to turn this into a good deal when paired with a sale. Keep them on hand for those mornings when you are moving slow, run out of time and need a breakfast on-the-go!


Have a regular haircut. Nothing brings down the appearance of hair quite like split ends. A trim will help your hair to look revitalised and refreshed.
Eat plenty of protein. Hair needs protein in order to grow and stay strong. If you notice any hair loss, consider the possibility that you need to eat some more protein.
Use a conditioning treatment. Choose something nourishing and rich that will leave your hair feeling soft and smooth. You may also want to use one overnight for intensive conditioning.
Protect your hair from the sun. It isn't just skin that gets damaged – hair can also become dry and brittle.


Maidenhair tree is probably one of the oldest species on Earth. It was here some 180 million years ago … obviously it was the time when the Dead Sea was still ill. Its extreme tolerance of various conditions made it survive to our time. One tree can live as long as 2000 years. And being so popular among growers and enthusiasts, it is no wonder that several varieties have been selected and hybridized to fulfill the dreams of plenty of ginkgo lovers.
Fastigiata Blagon is a French variety of maidenhair tree with narrowly conical or almost columnar growth. It bears deciduous, 4-7 cm wide, fan-shaped, divided, mid green leaves (botanically classified as needles), that change to fantastic shade of bright golden yellow in autumn. It is often pruned or sheared to achieve a more compact shape and denser habit which will help the tree produce a breathtaking show in autumn.
It grows relatively slowly with 30-40 cm per year. Mature size is expected to exceed 10m but the width is only between 2 and 3m. Maidenhair tree can withstand adverse conditions – heavy soil, air pollution, lack of moisture, extreme frosts. Once established it can take drought all summer long. For best results, however, grow it in medium fertile, well-drained, moist soil in full sun. Fully hardy to about -40°C (USDA zone 3).
This label guarantees a luxurious quality of manually selected plants that, compared to their height and age, are exceptionally dense and beautiful.


Leasing Available. Call Roberta Redrick at (336) 777-3667 for more information, and visit Sanur Brokerage for Floor Plans and pictures.
Albert Hall offers Premier Class A flexible professional space with floor plans that can be tailored to your specific needs. The current tenant profile includes a diverse composition of corporate, government, non-profit, and research occupational businesses.
Tenant amenities include a card access system with intercom capabilities allowing visitor screening/entry from your office. A conference or training room that can accommodate up to 15 participants is at your disposal. The building offers the convenience of a freight elevator as well as a passenger elevator. The VAV heating and cooling system maintains ideal interior temperatures year-round. Windowedpatios offer private outside space to lunch and observe the hustle-bustle of downtown activity. Floor-to-ceiling windows provide abundant natural light.
This historic, updated, 4 story building boasts a traditional brick facade, wood and marble floors meticulously maintained by a professional janitorial contractor. Located just 25 minutes from the Piedmont Triad International airport, Albert Hall provides quick access to Highways I-40, I-421 and Route 52 as well as walking or biking access to downtown shopping, dining and entertainment venues. Recycle bins on-site. All four floors have easily accessible men and women's bathroom facilities.
Apartments Available for Rent. Visit Norris & Stevens for more information.
Leasing Available. Call Roberta Redrick at (336) 777-3667 for more information and visit Sanur Brokerage for Floor Plans and pictures.
Victoria Hall is a three-story, premier, downtown Class A building located near Albert Hall, both sharing distinct historic designations. The flexible floor plans can fit many different needs and configurations. The location is unique and within walking distance to local businesses, but avoids the heavy downtown rush hour traffic due to its proximity to the highways.
The diverse, professional tenant profile includes corporate, government, and research occupational businesses. Attentive on-site management is only one of the many tenant amenities. Others include card access with intercom capabilities allowing for screening and entry from your office. There is a conference/training room available in Albert Hall that can accommodate up to 15 participants.
Convenient on site parking allows easy access to other local businesses.
This significant building features a traditional brick façade, a passenger elevator, a VAV heating and cooling system, and floor-to-ceiling windows offering an abundance of natural light. Recycle Bins, dumpsters and professional janitorial maintenance of all common areas keep Victoria Hall looking pristine. All three floors have easily accessible Men and Women's bathroom facilities.
The location of Victoria Hall is one of its prime features. It is less than 1⁄4 mile from I-40, I-421 and route 52. The Piedmont Triad International Airport is less than 25 minutes away. With neighbors like Winston State College, the Courthouse, and many other Municipal buildings, renting an office in Victoria Hall puts you at the center of a friendly, professional community.


Muscle needs to be stimulated from many angles to optimize growth.
Compound setting is founded on similar principals to supersetting.
Try the beginners compound set below for back and biceps.
One of the most effective ways to stimulate the growth of rock hard muscle in any part of the body is to totally fatigue that muscle group. It is not enough to simply fatigue a muscle group ... the key to growth is the ability to utilize as many different stimuli as possible in order to achieve this goal.
If it only took one or two exercises per workout session to spark growth then training the back and biceps would be simple. In that scenario you would grow thick sweeping lats and arms with peaks reminiscent of the ski slopes in Aspen with three sets of 1-arm dumbbell rows, lat pulldowns, alternating dumbbell curls and preacher curls for the biceps.
As Many Different Stimuli As Possible.
The fact of the matter is that muscle needs to be stimulated from many angles and in many ways to optimize growth. Compound setting enables you to fit in many exercises for a single body part as you can in each exercise bout.
Many people utilize supersets to maximize the amount of body parts that they can train during a workout session. As you may already know supersetting is the pairing up 2 exercises or more that work opposing muscle groups.
Compound setting is pairing the of two or more exercises that target the same muscle groups. Compound setting is founded on similar principals to supersetting.
The difference lies in the muscles targeted in the second exercise. The second exercise should target the same muscle group. What this does is to further recruit muscle fibers that may not get recruited from different angles.
Of Body Parts That They Can Train During A Workout Session.
Compounding the muscle fiber recruitment in a given area will further fatigue that area causing more damage and later on more physiological changes (growth). Compound setting also allows for you to accomplish more exercises for a certain body part in a shorter period of time.
Due to the fact that compound setting adds to the length of each particular set the muscle group will be totally decimated after only 4-6 sets.
This type of training will increase your muscular endurance as well. Each muscle in your body has a certain composition of either type 1 (muscular endurance) or type 2b (power and strength) muscle fibers.
Compound setting with a moderate to heavy weight targets both fiber types, thoroughly fatiguing the muscle. This also promotes maximal muscle growth and stokes your metabolism.
Given Area Will Further Fatigue That Area.
When choosing weights to begin compound setting, choose weights that you consider to be only moderately intense until you are familiar with compound setting. Pick a weight that you know that usually can manage for 3 sets of 12 reps but not 3 sets of 15 reps.
While compound setting you may only be able to complete 8-10 reps by the 3rd set. Try to use the same poundage through the entire workout. For instance, let's take a look at the back.
Train Insane With Kane, Episode #10: Insane Supersets, Serge Nubret-Style!
In Kane's tenth video episode, Controlled Labs guys Kane, PT, and glyph98 do an insane supersetted arms workout in the style of IFBB Pro Serge Nubret. 60 sets with no rest!
First choose exercises that complement each other. For example, it would be good to use two exercises that work completely different parts of the back. I will choose lat pull-downs and rear delt raises. Lat pull-downs will target the lats and biceps, the rear delt raises will target the rhomboids and rear delts.
Complete one set of lat pull-downs and immediately without rest complete a set of the rear delt raises. The completion of both exercise sets equals one full compound set.
Rest for 30-90 seconds and repeat 3 more times. Choose up to two more pair of exercises for the back taking care to choose different areas of the back with each exercise. That will amount to 24 sets in total. Because of how the workout is structured you should complete this routine in less than 40-45 minutes.
You can then do the same thing to the biceps in the next 10-15 minutes. You should only use 2 compound sets (4 exercises for 4 sets) as they are totally pre-fatigued. A great combo to hit is incline dumbbell curls and cable curls.
If you find that you cannot finish a set please stop for a couple of seconds and complete the number that you have allotted.
Choose Exercises That Compliment Each Other.
If you can stand the fire that will ignite in both your back and biceps and remain true to the short breaks you will feel a pump like no other workout! Build your better body with compounding one set at a time.
What Is The Best Supersetting Workout?
This week our forum members share with us what they think is the best superset workout. Get an exhaustive look at what supersets are and the routines that go with them. You will not be dissapointed.
Get Huge Like The Pros With This Intense 2 Part Back Workout!
Is your back workout hitting a wall? What you want is a back to be proud of - wide and thick like the pros. Learn how to add truckloads of muscle with this 2 part back workout!
Blow Up Your Biceps: Build New Levels Of Size And Strength - Weeks 1 - 4.
In one of my previous articles I said that I liked to put together 12 week workout routines or cycles, changing up the exercises every three or four weeks, and here is a great starting routine to get you through the first four weeks.


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Medi Assist appoints Manmohan Kalsy as President - Business Operations & HR
In his last stint as Chief Human Resources Officer at Inbrew Beverages, Kalsy led the areas of talent acquisition, training & development, and performance management.
Manmohan Kalsy, President - Business Operations & HR, Medi Assist
Medi Assist Healthcare Services on Tuesday announced the appointment of Manmohan S Kalsy as President - Business Operations and Human Resources.
In this role, Kalsy will be responsible for building a world-class team for delivering on Medi Assist's "Borderless Benefits" promise. Additionally, he will lead the integration of acquisitions and build a member-centric operations framework at Medi Assist, according to a statement.
Kalsy has over two decades of experience of working with leading companies like Gillette, Pepsi, United Breweries and Go First Airline, He has a track record of designing creative HR strategies and managing diverse teams. His experience also includes working in telecom, BPO, shared services and technology sectors with companies like Airtel, Vodafone and Xerox.
Satish Gidugu, CEO, Medi Assist, said, "We are happy to have Manmohan on board. His diverse experience and organisation-building capabilities from various sectors will help Medi Assist deliver on the motto "every employee a partner and every customer a commitment'."
Manmohan Kalsy, President - Business Operations & HR, Medi Assist, said, "I see my biggest goal is to align HR actions and people capabilities to impact business outcomes. Working on people's capabilities to accomplish far more—to jump higher, run faster, see farther, and maybe even challenge the status quo. I'd also be focusing on leadership development and integration of new acquisitions."
Recently, Medi Assist made its first international acquisition by acquiring a majority stake in Mayfair We Care, a UK-based healthcare-focused administration service provider with a presence across the world. The partnership allows Medi Assist to expand offerings for its customers beyond India and provide access to medical benefits and health plan administration in over 150 countries, as per the statement.
medi assist
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President - Business Operations & HR
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Why do most leaders manage to create success stories, but not all manage to successfully create legacies?


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text:
Q: Correlated Subquery, oracle sql I am working on my homework and I couldn't figure it out this problem. Can anyone help me please? This Oracle Sql
Display each invoice amount that is higher than the vendor's average invoice amount.
       You must use a correlated subquery.
I tried but I am not that close. Here my code is:
    SELECT vendor_id, invoice_number, invoice_total
FROM ap.invoices
WHERE invoice_total  >  (SELECT AVG(invoice_total)
                     FROM ap.invoices
                     where invoice_id=invoice_id
                     )
ORDER BY vendor_id;

Result table should match this image  :
   https://i.stack.imgur.com/w9D6i.png

A: Use an alias for the outer query table, and correlate on the vendor_id field:
SELECT vendor_id, invoice_number, invoice_total
FROM ap.invoices i
WHERE invoice_total  >  (
    SELECT AVG(invoice_total)
    FROM ap.invoices v
    where v.vendor_id = i.vendor_id
)
ORDER BY vendor_id;

redpajama_set_name: RedPajamaStackExchange


10. The subway is hard to understand at first. But after a few mistakes, you will get to know how to use it.
9. Get a map. Get one that will fit in your pocket. Your going to use it. Yes maps are for pussies, but its going to help you.
8. People in New York city don't know whats going on either. Find out yourself.
7. There are a lof of shoe joints in New York City. Stay awak from all of them.
6. It is expensive in New York.
5. There is not free internet all over New York, but you can find it somewhere.
4. Know before you go, find out where the shoe stores are before you get on the plane.
3. You can't get into studio 54, don't even try.
2. New York is a lot of fun.
1. Don't compare New York to LA. Because it all comes down to transportation.


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It's about time (a year later!) I finally found the time to blog about this project which I dreamed about for a long time and then finally found the perfect team to work with and my dream project came alive.
So the book I am referring to is "The Little Price" by Antoine de Saint-Exupéry. I read this book when I was about 10 years old while on my summer break on grandma Tamara's couch (yes, I was named after her, lucky me!) .Oh, how I would love to turn the time back just for 10 min and visit that time of my life… This book helps with that for sure… The book is not very big, so if you have 1-2 hours free – take it from the library and read it. You'll find it very interesting.
So, here it is I proudly present to you not one of the easiest projects I worked on, but one of the most memorable for sure..
And just some back and whites I edited just now.
3. As a result: a beautiful hand made in Italy photo book; a touching video based on the shoot; and a CD with the images (the only collection which comes with it) and memories to treasure forever.
And I saved some behind the scenes photos for the very last.


text:
Posted inChina, Greater Bay Area, Hong Kong, Macau
HK fintech can connect cities in Greater Bay Area
Hong Kong now has eight licensed virtual banking firms
by Sylvia Chen May 27, 2019 February 18, 2020
Ceajer Chan Ka-keung. Photo: Asia Times.
To date, Hong Kong has issued eight virtual-banking licenses. This new form of financial institution has been under the market spotlight. Ceajer Chan Ka-keung, senior adviser and chairman of local fintech startup WeLab, one of the eight licensed firms, said every bank had its own strategy but it was unlikely to trigger a price war.
Including these eight virtual banks, there now are 160 licensed banking groups in Hong Kong. How to sustain their businesses in a highly competitive market is the first challenge for virtual banks. Chan stressed that banks cannot make profits in the beginning because of technology and labor costs. However, based on his company's business model, Chan is confident that his firm will meet its targets.
Chan said WeLab was granted its virtual-banking license more than a month ago and was now making preparations to go into operation, including strategic development and talent recruitment. He said WeLab would commence operations six to nine months after it was granted the license.
WeLab is the first virtual banking institution founded by a local financial-technology firm in Hong Kong, while the other seven players are backed by technology or financial firms. When asked about competitors, Chan said every bank in the city had its own interest rates and strategies, so engaging in a price war was the last thing they wanted to do. He believes virtual banks will jointly create a healthily competitive market and bring the best user experience to customers.
Before WeLab, Chan was the secretary of the Financial Affairs and Treasury Bureau of the Hong Kong government. He said the regulation on virtual banks was the same as that on traditional banks.
Talking about the Greater Bay Area, he said it would be good to increase the connectivity among different cities in the area, especially in the virtual-banking and fund-management sectors under China's capital-account policies. He hopes financial institutions will be able to provide more cross-border services to corporate and individual customers in the area.
Launched in February, the Outline Development Plan for Guangdong-Hong Kong-Macau-Greater Bay Area highlighted Hong Kong's role in the innovative technology sector. As a global financial hub, Hong Kong has been accelerating its development of financial technology over the past few years, contributing to the development of the Greater Bay Area, Chan said.
In the Greater Bay Area, there are the "one country, two systems" policy, three currencies and three tax systems, which caused some people to worry about the problems related to cross-border regulations.
As there will be more and more financial services in the Greater Bay Area, Hong Kong's fintech sector can play an important role in helping solve regulatory problems, Chan said. It is also an important opportunity for Hong Kong's financial industry.
This article was first published on ATimesCN.com and was translated by Kamaran Malik.
Tagged: ATimesCN, Business, China, Economy, Finance, Greater Bay Area, Hong Kong, Macau, news, Technology


Barbara Moller and Ed Winders met while abroad in 2004. Over the next decade, they founded a nonprofit global aid organization and settled into a home in the Lower Garden District. In mid-November, they traveled to San Miguel de Allende, a colorful colonial-era city in Mexico's central highlands, with the intention of looking for potential real estate during their stay.
But they never got the chance. Less than 48 hours after they arrived, they were found dead by apparent carbon monoxide poisoning inside their vacation rental.
The American consulate called Carl Moller, Barbara's only child, after the rental's owners smelled gas and discovered the couple dead inside their temporary residence. Carl Moller was the last to say goodbye to his mother and Ed in New Orleans before they embarked on their 10-day vacation to Mexico, a country beloved by Barbara who studied Spanish in college and adored the local culture.
"I went into zombie and shock mode and continued off to work before I really understood what had happened," said Carl Moller.
Since that initial call, Carl Moller and Ed Winders' two children — Jennifer and Eric — have surmounted geographical and language barriers, piecing together information about their parents' deaths. It appears the couple checked into their rental on Nov. 15 and went to sleep that night. The rental's owner did not hear from them the next day, but just assumed they were "doing their thing around town," said Eric Winders.
By the next afternoon, the owner smelled gas emanating from the rental. She and her husband entered the residence and found the couple dead inside, said the couple's children.
Based on the initial findings of the investigation, Carl Moller said a faulty heater is to blame. Carbon monoxide can leak from gas appliances, such as heaters. When not vented properly, the odorless and colorless gas can build up in close quarters and poison any people inside, according to the Center for Disease Control. If someone is sleeping during a leak, they can die without feeling any precautionary symptoms.
Most homes have carbon monoxide detectors. This one did not, according to the duo's sons. The families tell the story of Barbara and Ed's deaths as not just a precautionary tale of the dangers of carbon monoxide, but the relative lack of safeguards taken by some vacation rental sites.
"These sites should provide renters with a checklist of what to look for in new homes. Carbon monoxide detectors are cheap and portable. You can bring them with you," said Carl Moller.
The couple's death is the latest in a series of deaths of vacationers in Mexico due to faulty gas installations. Last March, an Iowa couple and their two children died from a gas leak in a water heater at a rented condo in Mexico's Caribbean coast resort of Tulum. In 2010, an improperly installed gas line caused an explosion at a hotel in the nearby town of Playa del Carmen that killed five Canadian tourists and two Mexicans.
Both sons agreed the tragedy should not prevent travelers from visiting Mexico.
In fact, Barbara Moller and Ed Winders dedicated much of their lives to breaking down the barriers between cultures and connecting with communities beyond their own. After meeting in 2004, the couple founded Voices for Global Change, a nonprofit organization based out of their Lower Garden District home, which rallies behind the "belief that when people who have had no voice, speak, they change their world," according to VFGC's website.
The organization implemented aid projects in Africa, southeast Asia and the Caribbean. Moller spearheaded a micro-enterprise in Uganda called Paper to Pearls, which empowered displaced young woman to sell their paper jewelry both locally and internationally.
"They just wanted to do good in the world," said Carl Moller.
Seven years after making the move from Virginia, Ed Winders and Barbara Moller were infatuated with the charm and activity of New Orleans. They could be spotted in the auditorium of the Orpheum Theater during open rehearsals by the Louisiana Philharmonic Orchestra or meandering around any one of the cities many festivals. At some point, Winders struck up a friendship with trumpeter Leroy Jones and coaxed him into giving a music lesson to his granddaughter, said Eric Winders.
As of Wednesday, the investigation into the couple's death by Mexican authorities remained ongoing. Their bodies will stay in San Miguel de Allende until the investigation concludes. Eric Winders and Carl Moller realize it will be a while until they receive any closure in this strange and sudden twist of events.
"Life is impermanent. We all know it. But when it hits you in this way, that realization is not much consolation," said Eric Winders.


existing or occurring in a high or extreme degree: intense heat.
acute, strong, or vehement, as sensations, feelings, or emotions: intense anger.
of an extreme kind; very great, as in strength, keenness, severity, or the like: an intense gale.
having a characteristic quality in a high degree: The intense sunlight was blinding.
strenuous or earnest, as activity, exertion, diligence, or thought: an intense life.
exhibiting a high degree of some quality or action.
having or showing great strength, strong feeling, or tension, as a person, the face, or language.
susceptible to strong emotion; emotional: an intense person.
(of color) very deep: intense red.
2. fervent, passionate, ardent, strong.
c.1400, from Middle French intense (13c.), from Latin intensus "stretched, strained, tight," originally past participle of intendere "to stretch out, strain" (see intend); thus, literally, "high-strung." Related: Intensely.


text:
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BOXING: Joyce gunning for Rio glory in the ring, with high expectations
By Tim Ashton
JOE Joyce hopes to write his name in the boxing history books at the Rio Olympics, despite initially targeting Games glory through athletics.
The 30-year-old super heavyweight sealed his plane ticket to Rio last month by winning the European Olympic qualifying event in Turkey.
Having already won gold at the 2014 Glasgow Commonwealth Games and the inaugural 2015 European Games in Baku, Joyce is one of the more senior members of Team GB's boxing squad.
And the Londoner – who began at Earlsfield ABC in Wandsworth – was delighted to finally qualify for Rio after missing out on one of the automatic qualifying places on offer at the World Championships in Doha in October.
"It's about time I qualified for Rio. I'm really happy with the team, there's so many already qualified and it's great to finally secure my place," Joyce said.
"It's a long-term goal to go to the Olympics, I initially planned to get there via athletics, but I found I improved much more in boxing and have been successful doing that.
"The experience of winning a medal there would be amazing.
"I am quite experienced myself now, I've won major medals at the Commonwealth Games and the European Games, and they're essentially warm-up events.
"I already know what to expect and the emotions that come with it, but the Olympic Games is 10 times that, especially what it would mean afterwards.
"It would be great to represent the nation and go down in history."
Joyce has drawn comparisons to newly crowned IBF World Heavyweight champion Anthony Joshua, who also competed for Team GB in the super heavyweight class at London 2012 and went on to win gold.
In fact, Joyce defeated Magomedrasul Majidov in the final of the European qualifying event, who is the last man to beat Joshua at the 2011 World Championships.
But things could have been much different for all-round sportsman Joyce, who only began boxing at the age of 22 while he was studying at Middlesex University.
More than 60 per cent of gold medallists since 1992 having participated in BUCS sport, with 56 members of Team GB at the London 2012 Olympics competing for Great Britain at the World University Games.
And Joyce recalled one of the moments where he realised that his future lay in boxing when he was competing at a BUCS Championships in athletics.
"It's great seeing AJ do so well, he's led the way and he's a fantastic role model as well," Joyce said
"I avenged his last defeat at the European qualifiers and he congratulated me on Twitter.
"I started off playing three sports at the same time growing up, rugby from the age of six, swimming and karate, which later changed to kickboxing.
"But it wasn't until university age that I started training in athletics, I stopped playing rugby and was inspired to get to the Olympics.
"However I wasn't getting the right times or the right distances and I was at university wanting to let some aggression out and start hitting a bag.
"Funnily enough when I did a trial for the Team GB squad in Sheffield I thought the place looked familiar, I did a BUCS university competition there in athletics and got a bronze medal in the shot put.
"I didn't even get my medal, I was too busy upstairs watching the boxing!"
British Universities & Colleges Sport (BUCS) is the national governing body for Higher Education (HE) sport in the UK, organising leagues and competitions for more than 150 institutions across 52 different sports. Supported by Deloitte, BUCS offers programmes to athletes from a grass roots level through to Commonwealth and Olympic Games hopefuls www.bucs.org.uk
Gustard sees positives in Quins' defeat as Ibitoye-brace lays marker down
Cambridge 24 Rosslyn Park 20 - Park late rally not enough at Volac
AFC Wimbledon's Wally Downes given four-week ban after admitting betting charge
AFC Wimbledon suspend boss Downes after FA betting charge
Forss' late debut goal not enough in MK Dons defeat
Dons bring in three loan signings on deadline day
Ex-AFC Wimbledon chairman says keeping Gigg Lane vital for Bury phoenix club plans
Dons make decisive move to complete signing number six
Charlton sign former AFC Wimbledon captain


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text:
Q: Prove that if $\displaystyle\bigcup_{\alpha\in \Lambda}S_\alpha$ is a subring of $R$ then $(S,\subseteq)$ is a totally ordered set.
Problem.
Let $(R,+,.)$ be a ring. Let $S:=\{S_\alpha:\alpha\in \Lambda\}$ where $S_\alpha$ is a subring of $R$ for all $\alpha\in \Lambda$. Prove that if $\displaystyle\bigcup_{\alpha\in \Lambda}S_\alpha$ is a subring of $R$ then $(S,\subseteq)$ is a totally ordered set.

My Thoughts
I thought that I would proceed by assuming that $(S,\subseteq)$ is not a totally ordered set. This would mean the existence of two subrings $S_{\beta},S_\gamma\in S$ such that neither $S_{\beta}\subseteq S_\gamma$ nor $S_\gamma\subseteq S_\beta$ is true. In other words, we have both $S_{\beta}\not\subseteq S_\gamma$ nor $S_\gamma\not\subseteq S_\beta$. Which would imply that there exists two elements $x,y$ such that $x\in S_\beta$ but $x\not\in S_{\gamma}$ and $y\in S_\gamma$ but $y\not\in S_\beta$. I wanted to show that at least one of the elements $x-y$ and $xy$ willn't belong to $\displaystyle\bigcup_{\alpha\in \Lambda}S_\alpha$. But there I got stuck.
Can anyone help me?

A: As it was pointed in comments this is wrong as stated.
One way to correct it is the following:
Let $(R,+,.)$ be a ring. Let $S:=\{S_\alpha : \alpha \in \Lambda \}$ where $S_\alpha$ is a subring of $R$ for all $\alpha \in \Lambda$. Prove that $(S , \subset)$ is a totally ordered set if and only if $\cup_{\alpha \in \Gamma} S_\alpha$ is a subring for all $\Gamma \subset \Lambda$.
$\Rightarrow$ is trivial as a subset of a totally ordered set is totally ordered.
$\Leftarrow$ is easy to prove by looking to the cases when $\Gamma$ has exactly 2 elements.


text:
< Back To All News
COPD National Action Plan aims to reduce the burden of the third leading cause of death
May 22, 2017, 11:00 AM EDT
The National Heart, Lung, and Blood Institute (NHLBI), along with federal and non-federal partners, today released the first-ever COPD National Action Plan, a detailed, patient-centered roadmap for addressing one of the most urgent health concerns facing Americans. The plan was released at the American Thoracic Society International Conference meeting this week in Washington, D.C. NHLBI is part of the National Institutes of Health.
The third leading cause of death in the United States, chronic obstructive pulmonary disease, or COPD, affects 16 million Americans diagnosed with the disease and millions more who likely do not know they have it. The disease, which costs Americans more than $32 billion a year, can stifle a person's ability to breathe, lead to long-term disability, and significantly affect quality of life. This forward-looking plan—developed with the COPD community nationwide and at the request of Congress—offers a unified, coordinated approach to ending the COPD scourge by identifying the specific work patients, doctors, educators, researchers, federal agencies, advocates, and the biomedical industry can do to make a difference.
"This plan represents a new understanding of what it takes, at every level, to minimize the burden of COPD," said Gary H. Gibbons, M.D., director of NHLBI. "Through thoughtful collaboration with federal agencies, patients, advocates, and researchers, we will help the millions who continue to endure this debilitating disease."
While COPD is not curable, it is often preventable and highly treatable, and early diagnosis can lead to improved outcomes. The newly-released action plan seeks to build on what the health and scientific communities already know about the disease by focusing on five goals:
Empower patients, their families, and caregivers to recognize and reduce burden of COPD
Equip health care professionals to provide comprehensive care to people with COPD
Collect, analyze, report, and disseminate COPD data
Increase and sustain COPD research
Turn COPD recommendations into research, and public health care actions
To produce the plan, NHLBI announced and organized workshops and in early 2016 convened stakeholders of the COPD community, including patients and their families, health care providers, academics, and industry representatives, for a national COPD Town Hall. The comments shared at the COPD Town Hall directly informed the action plan, and engagement of the community remained integral to the plan, as its five goals were refined. In October 2016, NHLBI invited the public to review and comment on the draft action plan, and used that feedback to finalize the plan.
"The enthusiasm of members from the COPD community in sharing its insights has been invaluable throughout this process," said James P. Kiley, Ph.D., director of NHLBI's Division of Lung Diseases. "The different perspectives brought by those who live these issues every day contributed to making this a clear, coordinated way forward for all stakeholders. We look forward to working together to improve the lives of those living with COPD."
The COPD National Action Plan provides a cohesive tool for health professionals and advocates to raise awareness about COPD and support activities that can change the trajectory of the disease.
To learn more about the COPD National Action Plan and how to get involved, visit: COPD.nih.gov.
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Part of the National Institutes of Health, the National Heart, Lung, and Blood Institute (NHLBI) plans, conducts, and supports research related to the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, and blood diseases; and sleep disorders. The Institute also administers national health education campaigns on women and heart disease, healthy weight for children, and other topics. NHLBI press releases and other materials are available online at http://www.nhlbi.nih.gov.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
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