text:
Convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (III)1 1 T. Harayama, K. Nakatsuka, H. Nishioka, K. Murakami, N. Hayashida, and H. Ishii, Chem. Pharm. Bull., accepted. Synthesis of nitrocoumarins
Takashi Harayama, Kazumitsu Nakatsuka, Hiromi Nishioka, Kyoko Murakami, Yukiko Ohmori, Yasuo Takeuchi, Hisashi Ishii, Kazuhiro Kenmotsu
Reaction of nitrosalicylaldehydes (1) with carbethoxymethylenetri-phenylphosphorane in Et2NPh, in Ph2O, and in the absence of solvent (neat) at 210-215 °C was investigated. Reaction of 3-nitrosalicylaldehyde (1d) in Et2NPh afforded the benzoxazole (6) and the aminocoumarin (3e) along with the expected coumarin (3d). It was clarified that the origin of carbon-unit introduced for the formation of the benzoxazole ring came from the alkyl group of solvent.
https://doi.org/10.3987/COM-94-6910
10.3987/COM-94-6910
Dive into the research topics of 'Convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (III)1 1 T. Harayama, K. Nakatsuka, H. Nishioka, K. Murakami, N. Hayashida, and H. Ishii, Chem. Pharm. Bull., accepted. Synthesis of nitrocoumarins'. Together they form a unique fingerprint.
salicylaldehyde Medicine & Life Sciences 100%
Benzoxazoles Medicine & Life Sciences 96%
Molecular Farming Medicine & Life Sciences 80%
coumarin Medicine & Life Sciences 70%
6-amino-1,2-benzopyrone Medicine & Life Sciences 61%
Salicylaldehyde Chemical Compounds 58%
Coumarin Chemical Compounds 54%
Aminocoumarin Chemical Compounds 43%
Harayama, T., Nakatsuka, K., Nishioka, H., Murakami, K., Ohmori, Y., Takeuchi, Y., Ishii, H., & Kenmotsu, K. (1994). Convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (III)1 1 T. Harayama, K. Nakatsuka, H. Nishioka, K. Murakami, N. Hayashida, and H. Ishii, Chem. Pharm. Bull., accepted. Synthesis of nitrocoumarins. Heterocycles, 38(12), 2729-2738. https://doi.org/10.3987/COM-94-6910
Convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (III)1 1 T. Harayama, K. Nakatsuka, H. Nishioka, K. Murakami, N. Hayashida, and H. Ishii, Chem. Pharm. Bull., accepted. Synthesis of nitrocoumarins. / Harayama, Takashi; Nakatsuka, Kazumitsu; Nishioka, Hiromi; Murakami, Kyoko; Ohmori, Yukiko; Takeuchi, Yasuo; Ishii, Hisashi; Kenmotsu, Kazuhiro.
In: Heterocycles, Vol. 38, No. 12, 01.12.1994, p. 2729-2738.
Harayama, T, Nakatsuka, K, Nishioka, H, Murakami, K, Ohmori, Y, Takeuchi, Y, Ishii, H & Kenmotsu, K 1994, 'Convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (III)1 1 T. Harayama, K. Nakatsuka, H. Nishioka, K. Murakami, N. Hayashida, and H. Ishii, Chem. Pharm. Bull., accepted. Synthesis of nitrocoumarins', Heterocycles, vol. 38, no. 12, pp. 2729-2738. https://doi.org/10.3987/COM-94-6910
Harayama T, Nakatsuka K, Nishioka H, Murakami K, Ohmori Y, Takeuchi Y et al. Convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (III)1 1 T. Harayama, K. Nakatsuka, H. Nishioka, K. Murakami, N. Hayashida, and H. Ishii, Chem. Pharm. Bull., accepted. Synthesis of nitrocoumarins. Heterocycles. 1994 Dec 1;38(12):2729-2738. https://doi.org/10.3987/COM-94-6910
Harayama, Takashi ; Nakatsuka, Kazumitsu ; Nishioka, Hiromi ; Murakami, Kyoko ; Ohmori, Yukiko ; Takeuchi, Yasuo ; Ishii, Hisashi ; Kenmotsu, Kazuhiro. / Convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (III)1 1 T. Harayama, K. Nakatsuka, H. Nishioka, K. Murakami, N. Hayashida, and H. Ishii, Chem. Pharm. Bull., accepted. Synthesis of nitrocoumarins. In: Heterocycles. 1994 ; Vol. 38, No. 12. pp. 2729-2738.
@article{6f9ae69fd39342008c4fbc684544d7db,
title = "Convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (III)1 1 T. Harayama, K. Nakatsuka, H. Nishioka, K. Murakami, N. Hayashida, and H. Ishii, Chem. Pharm. Bull., accepted.: Synthesis of nitrocoumarins",
abstract = "Reaction of nitrosalicylaldehydes (1) with carbethoxymethylenetri-phenylphosphorane in Et2NPh, in Ph2O, and in the absence of solvent (neat) at 210-215 °C was investigated. Reaction of 3-nitrosalicylaldehyde (1d) in Et2NPh afforded the benzoxazole (6) and the aminocoumarin (3e) along with the expected coumarin (3d). It was clarified that the origin of carbon-unit introduced for the formation of the benzoxazole ring came from the alkyl group of solvent.",
author = "Takashi Harayama and Kazumitsu Nakatsuka and Hiromi Nishioka and Kyoko Murakami and Yukiko Ohmori and Yasuo Takeuchi and Hisashi Ishii and Kazuhiro Kenmotsu",
doi = "10.3987/COM-94-6910",
journal = "Heterocycles",
publisher = "Japan Institute of Heterocyclic Chemistry",
T1 - Convenient synthesis of a simple coumarin from salicylaldehyde and wittig reagent (III)1 1 T. Harayama, K. Nakatsuka, H. Nishioka, K. Murakami, N. Hayashida, and H. Ishii, Chem. Pharm. Bull., accepted.
T2 - Synthesis of nitrocoumarins
AU - Harayama, Takashi
AU - Nakatsuka, Kazumitsu
AU - Nishioka, Hiromi
AU - Murakami, Kyoko
AU - Ohmori, Yukiko
AU - Takeuchi, Yasuo
AU - Ishii, Hisashi
AU - Kenmotsu, Kazuhiro
N2 - Reaction of nitrosalicylaldehydes (1) with carbethoxymethylenetri-phenylphosphorane in Et2NPh, in Ph2O, and in the absence of solvent (neat) at 210-215 °C was investigated. Reaction of 3-nitrosalicylaldehyde (1d) in Et2NPh afforded the benzoxazole (6) and the aminocoumarin (3e) along with the expected coumarin (3d). It was clarified that the origin of carbon-unit introduced for the formation of the benzoxazole ring came from the alkyl group of solvent.
AB - Reaction of nitrosalicylaldehydes (1) with carbethoxymethylenetri-phenylphosphorane in Et2NPh, in Ph2O, and in the absence of solvent (neat) at 210-215 °C was investigated. Reaction of 3-nitrosalicylaldehyde (1d) in Et2NPh afforded the benzoxazole (6) and the aminocoumarin (3e) along with the expected coumarin (3d). It was clarified that the origin of carbon-unit introduced for the formation of the benzoxazole ring came from the alkyl group of solvent.
U2 - 10.3987/COM-94-6910
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JO - Heterocycles
JF - Heterocycles


text:
Q: Can hibernate persistent objects contain a collection of other persistent objects? I don't know if there is a feature for this or if I am making sense, but how this would work in my head is the persistent object would create a built in relationship between the persistent objects. The type of relationship would be annotation defined. Is there existing syntax and functionality for this hidden in the advanced features of hibernate that I haven't come across yet?

A: I believe what you are looking for is the @OneToMany annotation.
E.g.
class Detail {

  Long id;

  @ManyToOne @JoinColumn(name="parent_id", updatable=false)
  Parent parent;
}

class Parent {

  Long id;

  @OneToMany(mappedBy="parent")
  Set<Detail> details;

}

The collection property can be a different collection type (e.g. List). Hibernate will implement the appropriate semantics (e.g. unique children for the set, order for a list, etc).

redpajama_set_name: RedPajamaStackExchange


The stretch belt is used as part of a 1950's costume. It can be paired up with a 50's housewife dress or similar style costume from the period.
The stretch belt is colored as pictured. Fits up to a 28" waist.


Alpenglow Expeditions was founded in 2004 by IFMGA certified guide Adrian Ballinger. From the Himalaya to Lake Tahoe, Alpenglow leads expeditions across the mountain ranges of the globe in all disciplines including mountaineering, skiing, ski mountaineering, and rock climbing. With over 30 international expeditions per year and a full menu of ski and rock climbing courses in Lake Tahoe, Alpenglow Expedition's core values are founded on providing a unique experience for each client who desires to explore mountains across the world. Explore our website or call 877-873-5376 for more information.
Rapid Ascent is a unique program developed by Alpenglow Expeditions that combines the relatively new application of hypoxic training with precise logistics and small team sizes to greatly increase the chances of success while reducing the overall time spent away from home on an international expedition. The Rapid Ascent system in partnership with Hypoxico tents also allows climbers to utilize masks while training aerobically to further simulate the stresses the body undergoes at altitude. Combine the hypoxic training at home with our new way of approaching these mountains and you'll find that overall expedition times are shorter, you arrive at base camp healthier and ready to take full advantage of weather windows.
All of our international expeditions and climbs are led by AMGA and/or IFMGA certified guides. While this certification has long been essential for guides working in Europe, Canada, and New Zealand, Alpenglow is the first major guide service in the USA to require this certification from our lead guides. To earn AMGA certification in one or more disciplines, guides must spend years training and studying, after which they must pass a rigorous examination process. Guides that have passed exams in all three disciplines: rock, alpine, and ski mountaineering obtain the title of American Mountain Guide and IFMGA mountain guide. This achievement is the highest level of credential attainable by a mountain guide and takes many years of full-time guiding and climbing to attain. There are currently only approximately 130 IFMGA certified guides in the USA and they represent the pinnacle of American mountain guiding. We also have lead guides from Ecuador, and they too have passed rigorous exams to earn the title of IFMGA mountain guide. To learn more about the AMGA or IFMGA, click on their logos at the bottom of the page.
Our teams and client to guide ratios are kept small. This enables us to focus on each team member's goals for the trip, while also maximizing success and safety. Conditions in the mountains are constantly changing. Small teams can adjust while big teams are often stuck within their fixed logistics. Small teams also enable the members and guides to have a much more personal experience with the environments they are in, with the local people, and amongst each other.
Our guide and office team have spent over a decade working in each of the locations we offer trips. Through this time we have made incredible friends and local partners, ensuring that our logistics are at the highest level offered in the industry. You will immediately notice the difference between our services and others teams', whether by our food in basecamp, our local family-run hotel in town, or our friendly and knowledgeable local support staff. When climbing big mountains in foreign countries, the quality of these services is essential. It allows us to focus our strength and resources on climbing, knowing we have fantastic support.
Our expeditions and treks were created to combine our guides' passion for climbing big mountains with their desire to teach others. Our expeditions challenge team members to expand their decision-making and leadership skills and become more efficient and competent in the mountains. Every one of our expeditions is run as a partnership between the guide and you, ensuring your maximum learning, enjoyment, safety, and success.
Alpenglow Consulting provides industry leading logistics, risk management, rigging and certified guides for your commercial project. Alpenglow has extensive international and domestic experience working on diverse projects in mountainous environments. Whether it is a remote, high altitude setting, or a roadside rock climbing shoot, Alpenglow Consulting will ensure a cost effective, safe and successful production.
See what our clients are saying about our expeditions.


text:
Restaurant Review - The Coburg
When it comes to pushing the boundaries of contemporary cuisine, there's a fine line between fusion and confusion, says Lucinda O'Sullivan. Unfortunately, The Coburg at the Conrad Dublin has crossed that line.
Cork's Casual Revolution
Cork hasn't always been a trendsetter when it comes to Irish dining, says Lucinda O'Sullivan. But, lately, they've been riding a wave of hip, casual, unpretentious street food that's as tasty as it is cheap
Restaurant Review - Cirillo's
With a pedigree in Italian food, great things were expected from James Cirillo's eponymous new Dublin restaurant, says Lucinda O'Sullivan, and with authentic food in a cool setting, she wasn't let down
Restaurant Review - Forest & Marcy
Things got off to a slightly rocky start at the new Forest & Marcy on Dublin's Upper Leeson Street, says Lucinda O'Sullivan, but it soon became smooth sailing, as Ciaran Sweeney's outstanding food couldn't but impress
Our Latest Great Place To Eat - Baan Sujittra
The level of choice in this country, when it comes to varied cuisine, has really taken leaps and bounds forward. With the ever-growing foodie culture showing no signs of slowing down, we've never had so much choice where good food is concerned.

redpajama_set_name: RedPajamaCommonCrawl


It all began with few of our colleagues, being interested and dedicated to amateur singing, ran across Superior Singing Method that explains different singing styles and overall different music and its interaction with other things. http://www.EtnoMusic.com have described the process in one of their texts so you can check it out.
We also recommend you learn more about where you can get your gear, such as your tanning supplies. If you need tanning supplies for your art, it is perhaps the best way to go about it ordering online.


text:
Research/eLearning
Learn About the Library
4.10 - Materials Selection
The mission of the Royal Oak Public Library is to be an informational, intellectual, cultural and recreational resource for all people; to inspire the spirit, educate the mind, and be a center of community pride.
The Royal Oak Public Library receives funding from the people of Royal Oak to select and purchase collections which are valuable educational resources that inform or entertain, and provide open access to the world of ideas. The resources of Royal Oak Public Library include but are not limited to money, space and personnel. These resources are finite.
A decision to select a particular title or type of material may exclude some other title or material. The policies set forth below are designed to provide direction to professional librarians who have earned an MLS degree from an ALA accredited university and are charged with material selection duties. The Trustees of the Royal Oak Public Library understand that the policies adopted herein are in many instances general in nature and therefore not designed to replace, but rather supplement good judgment.
Objectives of Selection:
The objectives of the Royal Oak Public Library are to select, organize, preserve, and make freely and easily available resources which will aid in the pursuit of education, enlightenment, information and recreation.
Responsibility for Selection:
Library materials selection is vested in the director of the library, with the assistance of members of the professional staff of librarians who select resources in accordance with this Materials Selection Policy.
General Policies:
The Library is a forum for ideas and information. The primary goal of selection shall be to collect materials of contemporary significance and/or of permanent value which will enrich the collections and maintain an overall balance representing many points of view with respect to a given subject. In addition, the library, recognizing that demand is a valid and important factor in selection, shall make available some materials which may be in widespread and persistent demand such as books on the best sellers lists.
The policy of this library shall be to select materials in accordance with the above stated objectives for all people of the community. Materials shall not be excluded because of the origin, background, or the personal views of the author, as outlined in the attached ALA Library Bill of Rights.
Program Support:
The policies set forth in this document apply to materials selected for program presentation or content of programs as well as for the lending and reference collections.
The library welcomes gifts of books and other materials but reserves the right to evaluate, accept and/or reject, and dispose of them in accordance with the selection criteria applied to purchased materials. No conditions may be imposed by the donor relating to gifts, books and related materials made to the library. In accepting any gift, due consideration must be given to the resources necessary to receive, maintain and make such gifts available to the public.
When the library receives a cash gift for the purchase of library materials, the selection will be made by librarians in consultation with the donor and consistent with the Materials Selection Policy.
Gifts other than books and related materials shall be governed by Royal Oak Public Library Policy 2.10 Monetary and other non-book gifts.
Maintenance of Collection:
The same criteria will be used when removing materials from the collection as are used in their acquisition. In order to maintain the collection in its most useful state, materials which are no longer useful or which are not in a condition suitable for circulation will be removed from the collection. Such materials may be given to other libraries, sold for the benefit of the library, or discarded. Materials disposed of by sale must be pursuant to a public sale. The library is prohibited from selling to individuals by private sale.
Areas of Limited Acquisition:
Textbooks - Textbooks shall be provided only on subjects where there is little or no material available in any other form and where the text is considered enduring and useful to the general public and pursuant to agreements for collaborative services with area schools.
Law and Medicine - Legal or medical resources are collected as they benefit the general public. No attempt shall be made to build a comprehensive legal or medical collection.
Controversial Materials:
The collection shall contain resources which, in the aggregate, provide a balance of the various positions expressed on important, complicated or controversial questions. The public library shall not promote particular beliefs or views. It shall provide resources so that the individual can examine issues freely and make his or her own decisions.
Materials on controversial questions are to be considered critically in the following regards: The creator of the material should be known or thought to have some competence, be well regarded by esteemed peers, have attained critical acclaim, or some other comparable distinguishing contribution to bring to the subject. Material which is known to be libelous, or marked by distortion of facts, suppression of truth, or propaganda will not be approved for purchase or accepted as a gift.
Certain exceptions to these guidelines are likely to occur. Some titles, which might otherwise be objectionable, are primary sources or documents in the study of historical or contemporary political movements and organizations and may be made available, e.g., The Communist Manifesto and Hitler's Mein Kampf.
Request for Reconsideration:
If a patron objects to the presence of material on the library's shelves or in a library program, he or she may request reconsideration of an item by filling out a form available at the reference desks. The director will make the initial decision on the patron's request. If the patron is not satisfied with the director's decision, he/she has the right to appeal to the Library Board. The Library Board will announce the final decision at a public meeting to which the patron will be invited. Fair consideration will be given to every patron's request.
Request for Reconsideration of Library Materials Form
Adopted: 1/27/98; rev. 2/27/01; rev.7/27/04; reviewed 06/25/06; revised 09/26/06; revised 7/24/0; rev. 09/23/08; reviewed 07/27/2010; reaffirmed 7/26/2011; reaffirmed June 24, 2014, revised July 26, 2016.
1.10 - Mission
1.20 - Authority
1.30 - Royal Oak Public Library Board Ethics
1.40 - Library Board Meetings
2.10 - Monetary and Other Non-book Gifts
2.20 - Disposition of Furniture Equipment
3.10 - Auditorium and Meeting/Study Room Policy
3.20 - Free Literature and Bulletin Board Postings
3.21 - Displays and Exhibits
3.30 - Code of Conduct
3.40 - The Unattended Child
3.50 - Library Hours and Holidays
3.60 - Digital Video Security Cameras
4.13 - Art Acquisition Policy
5.10 - Circulation
5.101 - Circulation Parameters
5.11 - Registration
5.13 - Interlibrary Loan (ILL)
5.14 - Outreach Services to Home
5.20 - Reference Service
5.30 - Association with Other Libraries
5.40 - Internet Use Policy
5.41 - Internet Filtering
5.50 - Library Schedule of Fees
6.10 - Public Relations Policy
6.20 - Social Media Policy
7.10 - Staff Professional Development
7.20 - Library Board Trustee Continuing Education
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text:
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< GoodTherapy Blog >
Finding a Therapist Who Gets Your Career
• By GoodTherapy
It's no secret 2020 was a challenging year for all of us.
But the degree of those challenges might surprise you.
One study, for example, found that more than one in six Americans started therapy for the first time last year. Altogether, some 31 percent of U.S. citizens are now committed to improving their mental health and relationships by talking to professionals about what's going on in their lives.
This is an incredible thing.
However, while seeking therapy is definitely a step in the right direction, you can't just join forces with any therapist and expect great results.
If your goal is improving your mental health and becoming the best version of yourself, you need to make sure to partner with a right-fit therapist — someone who knows what you've been through, what you go through every day, and the best course of action for treatment.
According to the American Psychological Association, clients are more likely to achieve better outcomes when they have strong relationships with their therapists. That being the case, if you're a patient seeking therapy (PST), it's critical to do your due diligence to ensure that you end up sitting down with a right-fit therapist.
The Importance of Finding a Right-Fit Therapist
Imagine someone who drives a BMW gets into a car accident. This individual isn't going to bring their wrecked car to a landscaper; they're going to go to an auto body shop instead. And not just any body shop, either: In most cases, they're going to find a BMW-certified repair shop so that a team of skilled, experienced experts can restore the car to optimal condition.
The same concept holds true in the world of therapy. Not only do therapists use different methods to treat their clients, but they also specialize in unique areas of practice.
For example, some therapists might be experts in helping clients who are victims of sexual abuse, and others might focus on helping clients deal with the loss of a loved one.
Similarly, there are therapists who are skilled in treating clients who operate in niche industries that are uniquely demanding.
Why Look for a Therapist Who Gets My Industry?
If you're a person seeking therapy with a career in a field that most people don't understand, it is incredibly important that you get the specialized support of a therapist who really gets what it's like to be in your shoes.
This is exactly why GoodTherapy recently rolled out a new feature that enables you to filter search results using an "Industries & Communities served" filter. With this feature, it's never been easier for you to find therapists who understand what it's like to be in your shoes and can connect with you on a deeply personal basis — which is incredibly important since the relationship a client has with their therapist has a profound impact on the effectiveness of treatment.
Currently, the filter lets you find therapists who specialize in six different industries (and two communities – another topic for another blog post). We'll likely be expanding this list in the future.
With all this in mind, let's take a brief look at why people with each of these careers can benefit from a therapist who specializes in their industry.
1. Entertainment Industry
It's safe to say that entertainers of all stripes — musicians, artists, dancers, comedians, directors, and actors, to start — face unique pressures.
When they're just starting out, young performers can struggle to deal with being relegated to a secondary role. At the same time, the most "successful" can also become isolated from their peers. As they advance in their careers, entertainers can deal with all sorts of anxiety as they struggle to find their path. Performers can also have a hard time playing in front of large crowds. And what happens when the next play, movie, or album flops?
A therapist who has expert knowledge in these fields can be a great support to people experiencing these pressures. They'll know what questions to ask and what kinds of strategies to suggest to these clients.
2. First Responders and Medical Professionals
If you work in either of these capacities, you have seen things that most folks couldn't even imagine.
Whether you're the first responder to a terrible car wreck, a nurse dealing with COVID-19 patients, or a doctor who's had to tell families that their loved one didn't make it over and over again, you've experienced things most people never will.
By finding a therapist who deeply understands what this is like, you can connect on a truly deep level and work toward positive outcomes.
3. Military and Law Enforcement
Like first responders and medical professionals, military and law enforcement professionals have been through circumstances that most of us couldn't handle.
Suffice it to say that this group deals with chaotic, dangerous situations on a regular basis. Many military veterans have been in firefights and many law enforcement professionals have been in shootouts.
Pause for a moment to imagine what these people have truly been through.
Once you've had a chance to think, it's obvious why military and law enforcement professionals need to talk with therapists who can relate.
Teachers are expected to be happy, friendly, and cheerful at all times. But they're people just like everyone else, so it's not uncommon for them to be stressed, anxious, and overwhelmed every now and again.
Of course, the COVID-19 pandemic and all its associated impacts further compounded some of these issues. How many instructors ever signed up for a career teaching class over Zoom?
When professional educators are looking for therapy, they need to connect with therapists that understand academia, school boards, and student-teacher and teacher-parent dynamics.
5. Self-Employed and Freelance Professionals
If you run your own business, you know the struggle. Will I meet my revenue goals this month? What happens if I lose a handful of clients all at once? What should I do about employee issues?
Add it all up, and it comes as no surprise that more than 62 percent of small business owners say they feel depressed once a week.
A therapist who doesn't know what it's like to run a business is unlikely to be able to really understand what the race to keep the engine moving each month is like.
Luckily, there's an easy solution here: Set a goal of finding for a therapist who runs their own practice!
6. Professional Sports
Athletes and coaches live and die with every season — and, in some cases — every play. Competition is fierce, and the pressure continues to mount. Most athletes never know when their final game will be.
With salaries that can rise and fall at a moment's notice, uncertain career longevity, and everyone you know trying to get a piece of the pie, life can be downright difficult — despite what the average fan might think.
On top of all of this, it's not uncommon for athletes to experience aggressive hazing and incredibly inappropriate behavior before they turn pro — and well into their careers for that matter.
For these reasons, professional athletes — and those in the business, like general managers, coaches, and front office personnel — would benefit from finding a therapist who knows what it's like to have all eyes on you every time you go to work.
How Therapy Can Help You Deal with All Kinds of Issues
No matter what's causing trouble in your life, the right therapist can help you navigate the issues you're dealing with — including depression, anxiety, stress, compulsions, and fractured relationships.
When you join forces with a therapist who understands what you go through every day, you improve your mindset, your communication skills, and productivity — all while getting to know yourself on a deeper level, giving you a clear sense of purpose.
Are you ready to find a therapist who really understands what makes you tick?
Start your search today — and don't forget to use the "Industries & Communities served" filter. It'll be that much easier to find a therapist who can help you become the person you've always wanted to be.
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text:
Der Tirolerstein ist ein Gedenkstein auf dem Dollberg bei Neuhütten, unweit des Forsthaus Neuhof und dem Gedenkstein Horst Stüber, der dort in der Nähe bei einem Übungsflug mit einer F-104G Starfighter abstürzte. Er soll dem Tiroler Händler Thomas gedenken, der dort am 19. Januar 1741 einem Raubmord zum Opfer fiel. Im Jahr 1812 wird der Tirolerstein erstmals urkundlich erwähnt.

Geschichte
Der Tiroler Wanderhändler Thomas war seit 1740 öfter in der Hochwälder und Hunsrücker Gegend um seinen Geschäften nachzugehen. Hoher Schnee und Kälte ließen die Berghöhen des südlichen Hochwaldes im Januar 1741 unpassierbar werden. So, dass sich Thomas dazu entschied, in Abentheuer bei dem Wirt Roth zu übernachten, bevor er seine Reise fortsetzen konnte. Nachdem er vier Tage lang Quartier machte, startete er am 19. Januar 1741 Richtung Züsch um von dort weiter nach Malborn, Dhronecken und Hilscheid zu ziehen, um dort seine Waren auf den Märkten anzubieten. Nachdem er nicht in den Orten auftauchte und die Kaufmannskollegen sich um ihn Sorgten, ließ man nach ihm suchen. Ein Suchtrupp, bestehend aus einem Polizeiwachtmeister, den beiden Gerichtsschöffen des Amt Birkenfeld, Pauli und Faber, hatten den Auftrag den Züscher Wald "diesseits der Amtsgrenze durchaus wohl zu visitieren".  Dieser fand den gefrorenen Leichnam von Thomas am Vormittag des 23. Januar 1741. Die Gerichtskommission protokolliert dazu:

Verdächtigt war ein Knecht namens "Nicklas" aus Hoppstädten, der eben auch bei dem Wirt Roth genächtigt hatte. Verdächtig machte er sich dadurch, dass er in Hilscheid "mit allerhand Geld" angetroffen wurde. Ob er der Täter war, geht aus den Gerichtsakten nicht hervor. Der Heimatverein Neuhütten baute an der Fundstelle, an der sich zuvor nur ein schlichtes Holzkreuz befand, im November 1981 eine würdige Gedenkstätte aus Feldsteinen der Umgebung (Taunus-Quarzit). 1988 wurde das Holzkreuz erneuert. Eine Tischgruppe an diesem ruhigen Platz lädt Wanderer zum Verweilen ein.

Inschrift im Sockel des Gedenksteines mit Holzkreuz:

Beigesetzt wurde der Tiroler Krämer auf dem Friedhof in Birkenfeld.

Literatur
 Reitenbach, A. – Die Geschichte vom Tirolerstein, in: Heimatkalender d. Landkreises Birkenfeld, 1960, S. 170ff
 Schmitt, Rainer / Koltes, Hans-Josef – Neuhütten im Hochwald, Neuhütten 1989, S. 402ff
 Petto, Walter – Wanderungen aus Tirol und Vorarlberg in das Saarland, Saarbrücken 2000, S. 45
 Kreis Trier-Saarburg : ein Jahrbuch zur Information, Belehrung und Unterhaltung. Mord an dem Tiroler Händler Thomas 1741, 1983. S. 290–293.

Einzelnachweise

Gedenkstein
Neuhütten (Hochwald)

redpajama_set_name: RedPajamaWikipedia


IMMO is still the expert in motorized aids that help and prevent mobility problems for people and businesses.
Over the last six months we have undergone a complete restructuring of our business, where we have strengthened our design, development and production capabilities. In future IMMO will be an even more value-creating partner in the process of developing customised solutions for rehab, and in the industrial, service, health and care sectors. We feel that we have become an even better version of ourselves, and therefore we have changed our name from the UB-let to IMMO.
The engine solutions are always manufactured at our own factory in Denmark and are delivered as OEM solutions for companies in many different industries.
The goal is to constantly create solutions either on existing machines or build machines from the bottom for an individual person or general use while optimising by breaking daily routines. It benefits both the employee and employer, which is why, we say that we are working for free movement for people.
To hold a skilled employee while optimising on time gives a good result for both the employee and employer, which is why, we say that we are working for the free movement for companies.
In Volt Hockey you only encounter obstacles in the form of opponents and players, and sometimes the referee.
Experience an improved work environment by using a weight trolley, and avoid heavy lifts and moves of weights when testing lifting equipment.


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Sam J. Miller
Sam J. Miller is the Nebula Award–winning author of The Art of Starving (an NPR best book of the year) and Blackfish City (a Nebula Award finalist and a John W. Campbell Award winn...показать большеSam J. Miller is the Nebula Award–winning author of The Art of Starving (an NPR best book of the year) and Blackfish City (a Nebula Award finalist and a John W. Campbell Award winner). Sam is a recipient of the Shirley Jackson Award and a graduate of the Clarion Workshop. His short stories have been nominated for the World Fantasy, Theodore Sturgeon, and Locus Awards, and reprinted in dozens of anthologies. He lives in New York City. показать меньше
Книги автора Sam J. Miller
The Art of Starving
Автор Sam J. Miller
Blackfish City: A Novel
Аудиокниги автора Sam J. Miller
The Blade Between: A Novel
Come Join Us By the Fire
Автор Molly Tanzer
57 Reasons for the Slate Quarry Suicides
Destroy All Monsters
The Art of Starving: A Novel
Молодежная лит-ра о семье
Молодежное фэнтези
Молодежная лит-ра ЛГБТ+
Молодежные социальные темы


Registration fee includes t-shirt and prizes.
Youth players will be introduced to football skills that are used throughout the CAK football program. Drills are designed to improve skills, while at the same time promote fun and competition. Players will be divided according to grade and skill level to ensure the best camping experience. Head coach Travis Mozingo and his staff will lead the camp. Portions of the CAK football staff and team will also participate throughout the week's activities.
WHAT TO BRING: Gym shoes, water bottle and a snack. A small concession area will be set up for campers to purchase a snack if they choose. All items will be $1.
I do hereby fully release, discharge and agree to hold harmless and indemnify Christian Academy of Knoxville, its Board of Trustees, the CAK Football Camp, officers, administrators, teachers, coaches, employees, agents, participants and designated volunteers (jointly "Releases") from any and all claims or causes of actions for liability, injuries, death, loss, costs, damages, or expenses including attorney's fees, related to any and all claims or causes of action of any type against the Releases related to my child's participation in the CAK Football Camp. I further hereby authorize any of the Releases to act for me in their best judgement in an emergency requiring medical attention. I acknowledge that I have read and understand this authorization to participate and waiver/indemnify and agree to the terms and conditions set forth herein by my signature(s) below.


Security Question: Please Select What was the year and model of the first car you owned? What is the middle name of your youngest sibling? What is the last name of your most memorable teacher? What elementary school did you attend? Where (what city) were you living in at age 14? What is your favorite book? What is your pet's name? What is your favorite vacation? What is your favorite sports team? What is your favorite movie?


PORTAGE, Ind. (AP) — Environmental groups are urging northwest Indiana residents to comment on a proposed federal settlement over a U.S. Steel plant's discharging of a potentially carcinogenic chemical that entered a Lake Michigan tributary.
The (Northwest Indiana) Times reports that the public comment period on the proposed settlement ends June 6. Save the Dunes and the Ogden Dunes Environmental Advisory Board will host a public meeting Wednesday about the settlement.
That settlement calls for U.S. Steel to pay nearly $900,000 in fines and penalties for spills at its Midwest Plant in Portage, daily tests for hexavalent chromium, create a preventative maintenance program and upgrade pollution monitoring.
One spill in April 2017 resulted in almost 300 pounds of hexavalent chromium dumped into the Burns Waterway, which feeds into Lake Michigan.


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LastPass password manager's free tier is about to become a lot less useful
By Paul Lilly published 17 February 21
Users of the free service will soon have to choose between PC or mobile devices.
The best passwords are long, convoluted strings of characters and symbols, and are also difficult to remember. It gets even more challenging when juggling multiple passwords for different sites and services. This is where password managers come into play, and LastPass in particular is a flexible and handy option. It's also free to use, though the pro bono tier is about to get significantly less flexible for some users.
Dan DeMichele, vice president of product management at LastPass, announced in a blog post some upcoming changes to the free tier. The biggest one is a separation between 'computers' and 'mobile devices'. In just a few weeks, users of the free service will have to choose between one or the other, or upgrade to a monthly subscription to continue using LastPass across all devices.
The change goes into effect on March 16, 2021. Your first login on or after that date will dictate which tier you fall into. If you log into LastPass on a desktop or laptop, the password manager will set your active device type as computers, granting access to an unlimited number of devices with that category. Likewise, if you sign into the service on a smartphone, tablet, or smartwatch, it will set your active device type as mobile.
"You'll have three opportunities to switch your active device type to explore what's right for you. Please note, that all of your devices sync automatically, so you'll never lose access to anything stored in your vault or be locked out of your account, regardless of whether you use computer or mobile devices to access LastPass," DeMichele explains.
Perfect peripherals
(Image credit: Colorwave)
Best gaming mouse: the top rodents for gaming
Best gaming keyboard: your PC's best friend...
Best gaming headset: don't ignore in-game audio
LastPass added the ability to sync between any type of device in November 2016, just over a year after LogMeIn acquired the service. It was a welcome change, and especially useful now, as more people find themselves working from home and on the go. And that is part of the reason why LastPass is rolling things back to the way they were more than four years ago.
"This change is part of our increased focus on delivering future Premium product improvements as the security landscape continues to evolve in this new era of remote work," a LastPass spokesperson told Engadget.
The spokesperson went to say that the Premium tier will become more valuable over time as more features are added. They also noted that this change brings the free tier "in line with other leading password managers who have more limitations."
Put another way, LastPass feels justified in suddenly gimping its free service to bring it line with less useful alternatives. We understand the economics of nudging users to a paid tier, but why not focus wholly on making the the subscription service more appealing on its own merits, rather than pulling the rug out from under free users?
There is also one other change, though fortunately it is easier to digest—beginning May 17, 2021, email support will be limited to Premium and Families subscriptions.
To soften the blow, LastPass for a limited time is offered a reduced subscription rate to its Premium tier, which is now available for $2.25 per month (billed annually), down from its regular $3/month rate.


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Solutions for some of the riddles of the Python Challenge.
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See http://www.pythonchallenge.com/ for more information.

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From Porto Covo, one of the most emblematic villages of the Alentejo Coast, FourWinds is a tourism company, which, with their discovery of secrets and their accumulated experience over the years, is focused on offering fun.
Guided walks on the Fishermen's Trail, softcoasteering and boat trips, are the principal activities offered by FourWinds.
With families in mind, FourWinds creates authentic amusement parks, with inflatables, trampolines and other leisure equipment, which guarantee moments well spent between parents and their children, above all in the Spring and Summer.
Softcoasteering, guided walks on the Fishermen's Trail and boat trips, are the principal activities offered by FourWinds. Travelling on foot at low tide, exploring caves and crevices, climbing rocks and swimming, hiking and discovering the flora and fauna of the region, or going along the coast between Porto Covo and Milfontes by boat and seeing the Rota Vicentina from the sea, will certainly make your visit even more special. Take the risk, try something new!


Finding a good burger joint in Costa Rica has proven difficult even though ironically, one of the country's major exports is beef. One place we've found in our neighborhood is Jettsy, which has a great bacon cheese burger with fresh french fries. They are good, almost great, but not extraordinary like so many places you can find in the US (Big Daddy's Burger Bar, Fuddruckers, etc.) who have more toppings than you could ever imagine.
After considering opening a burger place just to have class A beef and all the toppings Costa Rica has to offer, this weekend toiled with a few recipes and cooked a batch on our grill with Willingham's seasoning of course. We topped them with pineapple-jalapeño salsa, some fresh farmer's market tomatoes, sauteed green beans and grilled plantains.
Thanks for the comment Betty. I'm about to redesign the site, so check back soon!


An experience of the summer of 2016 supporting Bradford City.
George Green will not be joining Bradford City and Dylan Mottley-Henry has joined Barnsley as Stuart McCall and Bradford City's attitude towards risk becomes clearer.
Stuart McCall returns as Bradford City manager with an elongated training session at Guiseley which reminded one of what could have happened in 2007 had - as was the original thinking - McCall had been handed a healthy League One club.
Uwe Rösler is definitely joining Bradford City who are definitely going to be selling Bratwurst at half time and definitely paying one and a half million for Reece Burke who definitely posted a picture of himself in a City kit and he will definitely replace James McDarby who is definitely joining Parkinson at Bolton with Jamie Proctor who would definitely have scored twenty five goals this season as would Dylan Mottley-Henry who is definitely in the Barnsley first team by Christmas and definitely would have been brilliant for us as would George Green who is definitely the English Antoine Griezmann and Stuart McCall missed out in him because he is definitely not a proper manager and definitely just signing his mates which is odd because we definitely have not signed anyone but when we do sign people we will definitely be signing cheap German players who will definitely not be good enough but will be in the team because Edin Rahic definitely picks the team and all this definitely would not have happened if the Germans had not forced out Parkinson because the old boardroom definitely would not have forced a manager out and we definitely are going to be awful this year and definitely will be rubbish and under prepared and Greg Abbott definitely let Nahki Wells go because he does not know a good player when he sees one and why didn't we sign Tom Bradshaw anyway because without him there is no chance at all of promotion and without Josh Cullen there is no chance of even winning a game and the young players are definitely not going to be given a chance because Omar Daley is definitely coming back.
More about Antoine Griezmann, Dylan Mottley Henry, Edin Rahic, George Green, Greg Abbott, Jamie Proctor, Josh Cullen, Nahki Wells, Omar Daley, Phil Parkinson, Reece Burke, Stuart McCall, Uwe Rösler.
Napoléon Bonaparte is reported to have said that that if the French army was left without someone to fight then they would fight themselves, or within themselves more probably and given that the Corsican was a veteran of his country's revolution one could see the origin of the thrust of his point.
In football it is given to being the same. The summer is long and there is nothing to do other than recall the Icelandic victory and look at the slow building of a team at Bradford City after the exit of Phil Parkinson. That team takes some interesting shapes but as new Head of Recruitment Greg Abbott freely admits it is behind where it needs to be.
Work must be done for signings to be made and – it would seem – is being done.
Watching George Green on Saturday was a long awaited pleasure for me who had followed his career so closely but as was observed at the time Green is a player who would be a good signing but probably not a good loan signing. To borrow Green from Burnley one suspects that a club will have to promise to play his every week and even ignoring the lack of first team experience he has had at any club – a handful of Tranmere Rovers games – promising to play someone else's attacking midfielders every week is an act of folly in League One where a gnarled defensive can get you – well – fifth.
Which is not to say that Green will not have a forty six game season for someone and be the finest player in the division – he may – but management is managing risk and there is a risk inherent in giving a starting shirt to a player who has not been blooded in the professional game. This was as true with Billy Knott as it is with George Green. It is true of Dylan Mottley-Henry too.
Dylan Mottley-Henry joined Barnsley of The Championship having been released by City months ago. It is a good move for Mottley-Henry but one doubts Adam Hammill will be sitting out many games to make room for him. To keep Mottley-Henry Bradford City – be it Parkinson or Stuart McCall – would have had to give the player a professional contract. No one knows how tight money is with the new regime at Bradford City but Championship money allows for more spending.
Mottley-Henry has a six month deal at Oakwell and if that does not work out then his cost is absorbed into the running of a Championship club. Less than the gates for when Newcastle United visit South Yorkshire. If the promising winger impresses then Barnsley reap the rewards, if not they hardly feel the pain. That is the difference between promotion and losing in the play-offs as starkly as it can be put.
Mottley-Henry, like Green, offers a risk which McCall and Bradford City are adverse to. Which tells us something else new about this new Bradford City, at least for now.
More about Adam Hammill, Barnsley, Dylan Mottley Henry, George Green, Stuart McCall.
There was a point in the history of Bradford City where the club took one turn, and could have taken another.
To be more accurate these points happen all the time but watching Stuart McCall take a Bradford City through pre-season at Guiseley I ended up thinking back to the days of January and February 2007 when Dean Windass was allowed to leave City and join Hull, and Colin Todd was sacked.
Todd's contract was up at the end of the season and it was an open secret that Julian Rhodes wanted McCall to replace him. The need for totemic best player Windass seemed to be over with Rhodes convinced that the Bantams had enough points that David Wetherall could not possibly get them relegated in his time as manager (which he did) and had he not Rhodes might have used – not certainly not needed – an investment from then supporter Mark Lawn.
And had Rhodes excersized restraint and kept Todd, or Windass, or both, or taken another option then McCall may well have arrived in June 2007 to the very type of situation he found himself in some nine years later.
But these things happen all the time. Had Notts County's one yarder in the first round of the League Cup 2011/2012 gone a foot lower then there would not be a Phil Parkinson legacy – such as it is – for McCall to adopt.
That legacy is not to be understated either. Parkinson has left City in rude health. The leanness of the squad in summer which caused so much consternation is purposeful and a feature of the majority of clubs outside the higher reaches of the game where lengthy deals on players are more often liabilities than assets. Only the foundations are secured in League One football these days.
And the foundations off the field are secured.
Parkinson – as far as the story is told – never walked into the boardroom and demanded money the club could not afford for players and given how easily led the boardroom seemed to be that is a good thing. That the squad last season was patched with loan players rather than panic purchases says a lot.
List the players from last season who City owned to still be at the club this season and names like Rory McArdle and Stephen Darby – both absent today and for the start of the season following operations – would be iterated through. Ben Williams and Jamie Proctor would not.
"The owl of Athena spreads its wings only with the falling of the dusk" – as Hegel should have said – and it seems that dusk has not come yet for Parkinson.
Rather than a reboot of 2007/2008 and McCall's first time as Bradford City manager in League Two it seemed that the manager was on the road not travelled, and playing in what could have been.
What was was an entertaining encounter. It would be wrong to talk about Guiseley as more than an extended and expensive training session and so to pick out specifics rather than trends seems to miss the point of the exercise.
Those trends though seemed positive.
The young players who stepped up from the lower ranks which Parkinson ignored and played with the élan of The Lisbon Girls allowed out to party for the first time. Daniel Devine's name suggests itself.
The trialists looked lively in a way that seemed different to those Parkinson brought in. All looked capable and some looked impressive. The wheat from the chaff comes in spending time with the characters and seeing how they fit into a unit which is what games like this are all about.
It was good to see George Green make a long awaited debut. George Green and the subject of paths not taken is interesting assuming you remember the name.
And of the new signings Nathaniel Knight-Percival did not have much to do while Nicky Law Jnr set up an equalising goal for Tom Hateley (trialist) to score from. That moment when Hateley equalised revealed the game for what it was. The Bantams were happy to kick the ball around but would not go home in a defeat. The gears shifted up after falling behind showed a team working fitness rather than working to win.
And all seemed new. Parkinson has left something good at Bradford City but his exit seems to have taken with it some of the stolid tenancies which mired City's thinking. All that was good seems good and all that was not seems new.
Which is not something that one would have expected.
More about Ben Williams, Colin Todd, Daniel Devine, Dean Windass, George Green, Jamie Proctor, Julian Rhodes, Mark Lawn, Nathaniel Knight-Percival, Nicky Law Jnr, Phil Parkinson, Rory McArdle, Stephen Darby, Stuart McCall, Tom Hateley.
This story works well when read with Archie Christie Day: Part 1, Part 2 and Part 3.
If you have never heard of George Green before today you are not alone. The fifteen year old who joined Everton for a fee which would rise to in excess of £1.75m is a virtual unknown yet in a list of the most expensive sales in the club's history Green would rank in the top three. Dean Richards cost a fee up to £2.135m to Wolves, Andrew O'Brien cost up to £2m, then comes Green.
How is it that this kid from Batley Carr that no one has heard of is a part of this deal which could pay for City's future?
Pull up a chair, dear reader, because the deal was being done on the day BfB spent with Archie Christie and now it is public we can fill in a few details.
Before we arrived for our early morning swim Archie Christie had been meeting David Moyes (the time to allow the manager get to training) to talk about Green but by the time we ended the day we had held in our hand a bid for the player from another Premier League Club.
The deal had been in the offing for sometime although it was coincidence that we got exposed to it (the day of the interview was enforced by mine & Jason's work commitments, Christie took the first day we offered some eight days in advance of the interview) although in setting up there was a time when I was on Christie's house phone and David Moyes was the mobile being told that he would be called back.
They agreed. Green played for one of Spurs' youth teams against Aston Villa and turned in a match winning performance in front of the the massed ranks of scouts. By the end of the game those scouts were literally chasing Christie to find out about the kid.
27 clubs – including top clubs from Germany and Scotland as well as the Premier League – registered an interest in George Green. Christie proudly showed us the DVD of the game in which Green scored a hat-trick. Fifteen in a game of lads older than he Green stood out, and two of the three goals he scored were superb. A mazy dribble with sublime finish and a first time curled goal that did recall Rooney were impressive enough to enchant youth scouts, Premier League managers, Chairmen, Directors of Football recruitment.
Christie had built up Green's confidence – a confidence he showed on the field against Aston Villa's kids who had a pair of central defenders rated as the best young pairing in England – by giving him a place in the Development Squad. Green is proof of concept for the idea of having a way to graduate players from the kids but not to the first team. Green could not have played in the first two months of City's season and even if he had the realities of League Two football probably would not have helped the player's development.
But playing in the middle area that Christie's Development Squad provided a place for City to build Green, and be sure of him. While in the Development Squad Christie and the coaches moved Green's play forward on the field, putting him into a more attacking role. One of the skills Christie is credited as bringing to his role (See Archie Christie Day: Part 2) is the ability to tweak a players game to develop it. In this case he nudged Green forward up the field and the results are there for all to see.
However Christie would not take all the credit for George Green and Peter Horne – and his team of coaches – have once again found a player and brought him to City who has provoked interest from the top division. The difference between Green and Tom Cleverly is not in the finding but the export. As I understand the deal for Green City have got more up front than the stand to make from the full Cleverly deal, sell on clauses aside.
One can hardly blame the club or the board for that. If you or I – well versed in watching football as we are, dear reader – watched a young player impressing in a youth team game would we know at what level he could go on to play at? Would we know if the player was England material or just someone who might play 150 lower league games? If some club offered lower six figures we might take that because we knew not what the player was worth and how the market worked.
It was obvious watching him work that Christie knew that market. He told the board that he would get over a £1m George Green, they were sceptical – I'm sure that many reading this article are sceptical about someone being able to pull a kid from the youth set up and sell him for more than Andrew O'Brien – but Christie has made good on his promise. Not only that but he had looked at a player and recognised what is rare talent (how many other 15 year olds get sold for £2m?) which might indicate that the man knows a thing or two about spotting players.
In the morning we spent with Christie the deal on the table had a limit to a buy out clause, and a few other points that at the end of the day had been changed. That was on Thursday and a different club so I would not be able to say what the final details were but I'm pretty sure that that deal will be superb for City.
It would have been great to watch George Green break into the first team, to cut a dash in claret and amber, and it is sad in a way that that will not happen but that income can pay for City's progress. The Development Squad is paid for and so are a good few first team players. Christie's hope is that with deal like Green City will be paying for the wages of three or four League One players in years to come.
The Green deal is a massive success for Bradford City and hopefully a massive one for Everton too – they have developed a few decent young lads in their time – and one which starts to move the club out of the era of relying on cash input from the chairmen and into a time when the club begins to not only pay for the year on year football but also for its own improvement.
I recall watching Dean Richards' last game for Bradford City and when he left for a deal which could have snuck over £2m with clauses that City could have got more. When Andrew O'Brien joined Newcastle for only £1.5m plus a bit I remember thinking that we should probably view his sale as being aggregate of the fee for Des Hamilton. Dean Windass for the £1m we paid for him, Robbie Blake for half of what we had valued him at. I've always thought that City's players leave cheap. I've seen that changing now.
George Green: Remember the name not because he is going to be the greatest player in the future of Bradford City but because his move could pay for the future of Bradford City and rather than being a product of blind luck this boon is brought about by a hard working youth development squad delivering players to a development environment and having a business environment which was able to maximise the opportunity.
More about Archie Christie, David Moyes, Everton, George Green, Peter Horne.


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All Topics ▸ Topic ▸ Arts & Leisure ▸ Movies » Late 80's or early 90's HBO horror/adult movie
horrormoviefan Posts: 1, Reputation: 1
Late 80's or early 90's HBO horror/adult movie
Please help me! :eek: There was this movie that was shown on HBO in the late 80's to early 90's about vampires, but it wasn't just a horror movie it was also kind of like an adult movie because the vampires went to a mansion on a hill to have well... (there's really not a nice way of putting this) orgies... can anyone help me with the title of this movie?? Please!! :D
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ZildjainDevil Posts: 2, Reputation: 2
I'm about 90% sure this film isn't hbo it's tales from
The crypt movie. And it stars Dennis Miller. Where he goes
Into this whore house, and discovers all the whores are
Actually vampires. And he gets strapped in to this sex
Wheel, because they noticed that he knew they were
Vampires.
If that's it then the tales from the crypt
Film is called ( Bordello Of Blood )
Thanks, Nick
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lilangus Posts: 13, Reputation: 3
Maybe a little late... lol... but I believe there was a movie called "VAMP"... been a while but I think it had a couple sequels also. Strippers, hookers, that sort of thing. Female vampires running around naked with red hair... wild movie.
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Looking for a late 80's/early 90's cartoon children's movie... [ 11 Answers ]
I must have seen this movie a hundred times and I have no clue what it is. The characters were creatures of some sort - mice, hedgehogs, something. The little sister of one of the mice, we'll call them for clarity's sake, got really sick and all the mice took her to an old woman mouse in the woods...
A really obscure/random children's movie from the late 80's early 90's [ 3 Answers ]
All right, I don't remember much from it, but it has been bothering me for a long time... so if anyone could help me out I will love you forever. The movie has a bad guy who I don't really remember, but his minions are dark and shadowy and might make mechanical noises when they move. There is a...
Late 80's early 90's TV show [ 16 Answers ]
Trying to remember the name of a TV show from the late 80's or early 90's about a guy who fought crime in a black robotic looking suit... not batman... live action... drove a modified motorcycle. He had an African American buddy who whore classic sunglasses that flipped up... That's all I...
Late 80's early 90's children's movie about penguins [ 8 Answers ]
OK I'm about to be 19 and the movie I'm looking for I ALWAYS watched when I was younger. It was about two baby penguins there was a blue one and a pink one and they get captured and put on a ship (I think it was winter). They are trying to escape from the ship and they hide behind a bunch of...
Kids movie from late 80's early 90's I think [ 11 Answers ]
There was a movie that I watched once when I was younger about a young girl who had dolls that came to life and they lived in a land that she could go to if she stepped through her mirror. I know it is not Alice and Wonderland. This movie was about the girl's grandma was getting older and she...


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10/14 voted
We don't have a biography for Joey King.
The Kissing Booth 3
It's the summer before Elle Evans is set to head off to college, and she has a big decision to make.
Stars: Joey King, Joel Courtney, Jacob Elordi, Molly Ringwald, Taylor Zakhar Perez, Maisie Richardson-Sellers, Meganne Young, Stephen Jennings, Carson White, Morné Visser, Bianca Bosch, Camilla Wolfson, Zandile Madliwa, Judd Krok, Sanda Shandu, Hilton Pelser, Frances Sholto-Douglas, Evan Hengst
In a small town in Massachusetts, a group of friends, fascinated by the internet lore of the Slender Man, attempt to prove that he doesn't actually exist - until one of them mysteriously goes missing.
Stars: Joey King, Julia Goldani Telles, Jaz Sinclair, Annalise Basso, Alex Fitzalan, Taylor Richardson, Javier Botet, Jessica Blank, Michael Reilly Burke, Kevin Chapman, Miguel Nascimento, Eddie Frateschi, Oscar Wahlberg, Danny Beaton, Marc Carver, Kris Sidberry, Angela Hope Smith, Damon D'Amico Jr.
A teenage girl discovers a box that carries magic powers and a deadly price for using them.
Stars: Joey King, Ryan Phillippe, Ki Hong Lee, Mitchell Slaggert, Shannon Purser, Sydney Park, Elisabeth Röhm, Josephine Langford, Alexander Nunez, Daniela Barbosa, Kevin Hanchard, Sherilyn Fenn, Raegan Revord, Alice Lee, Victor Sutton, Albert Chung, Michelle Alexander, Natalie Prinzen-Klages
Desperate to pay the bills and come through for their loved ones, three lifelong pals risk it all by embarking on a daring bid to knock off the very bank that absconded with their money.
Stars: Michael Caine, Alan Arkin, Ann-Margret, Matt Dillon, Joey King, Christopher Lloyd, Maria Dizzia, Morgan Freeman, John Ortiz, Siobhan Fallon Hogan, Peter Serafinowicz, Kenan Thompson, Josh Pais, Richie Moriarty, Seth Barrish, Ashley Aufderheide, Gillian Glasco, Jeremy Shinder
A young man's political awakening and coming of age during the days and weeks leading up to the Stonewall Riots.
Stars: Jeremy Irvine, Jonny Beauchamp, Joey King, Caleb Landry Jones, Matt Craven, David Cubitt, Vlad Alexis, Ben Sullivan, Andrea Frankle, Patrick Garrow, Alexandre Nachi, Karl Glusman, Otoja Abit, Jonathan Rhys Meyers, Ron Perlman, Larry Day, Nastassia Markiewicz, Rohan Mead
A high school student is forced to confront her secret crush at a kissing booth.
Stars: Joey King, Jacob Elordi, Joel Courtney, Megan du Plessis, Lincoln Pearson, Jack Fokkens, Stephen Jennings, Chloe Williams, Michael Miccoli, Juliet Blacher, Jesse Rowan-Goldberg, Chase Dallas, Carson White, Hilton Pelser, Judd Krok, Sanda Shandu, Joshua Daniel Eady, D. David Morin
The Boxcar Children: Surprise Island
The continuing adventures of Henry, Jessie, Violet, and Benny as they spend the summer on their grandfather's private island.
Stars: Joey King, J.K. Simmons, Gil Birmingham, Dane DeHaan, Griffin Gluck, Martin Sheen, Talitha Eliana Bateman, Stephen Stanton, Carter Sand, Davis Pak
Radium Girls
In the 1920s a group of factory workers advocate for safer work conditions after some of their colleagues become ill from radium exposure.
Stars: Joey King, Abby Quinn, Cara Seymour, Scott Shepherd, Susan Heyward, Neal Huff, Collin Kelly-Sordelet, John Bedford Lloyd, Joe Grifasi, Brandon Gill, Olivia Macklin, Colby Minifie, Greg Hildreth, Veanne Cox, Tom Galantich, Steven Hauck, Carol Cadby, Gina Piersanti
Smartass
A 15-year-old girl becomes intimately acquainted with a town in California after being released from prison.
Stars: Joey King, Luke Pasqualino, Yvette Nicole Brown, Marc Menchaca, Ronen Rubinstein, Noel Gugliemi, Trevante Rhodes, Tade Adepoyibi, Susan Angelo, Chris Brown, Adam Cagley, Maryam Myika Day, Arturo Del Puerto, D.C. Douglas, Vanessa Evigan, David A. Garcia, Lance Gerbino, Michelle Jubilee Gonzalez
The sordid lives of an addict, an ex-con, and a luchador collide when an organ harvesting caper goes very, very wrong.
Stars: Nicki Micheaux, Ricardo Adam Zarate, Jon Oswald, Shaye Ogbonna, Santana Dempsey, Mark Burnham, Jose Rosete, Jearnest Corchado, Clayton Cardenas, Olivia Lynn Benavides, Rich Cassone, Brett Easton, Josh Fried, Kelli Jordan, Ari Loeb, King Orba, Joey Puerto, Anna Pulido
The In Between
IMDb 5.32022
After surviving a car accident that took the life of her boyfriend, a teenage girl believes he's attempting to reconnect with her from the after world.
Stars: Kyle Allen, Joey King, Celeste O'Connor, John Ortiz, Kim Dickens, Diany Rodriguez, Anna Stadler, April Parker Jones, Donna Biscoe, Jeffrey Vincent Parise, Jadon Cal, Aleks Alifirenko Jr., Leander Suleiman, Nicholas Stargel, Millie Rose Evans, Becki Hayes, Drake Rodger, Christian Adam
The Lie
A father and daughter are on their way to dance camp when they spot the girl's best friend on the side of the road. When they stop to offer the friend a ride, their good intentions soon result in terrible consequences.
Stars: Peter Sarsgaard, Mireille Enos, Joey King, Cas Anvar, Patti Kim, Nicholas Lea, Devery Jacobs, Dani Kind, Alan Van Sprang, Rodrigo Fernandez-Stoll, Vesper Rusk, Skyla Fowler, Kate Carlin, David Cowgill, Matt Adler, Jennifer Crystal Foley, Jackie Gonneau, Clay Savage
In the sequel to 2018's THE KISSING BOOTH, high school senior Elle juggles a long-distance relationship with her dreamy boyfriend Noah, college applications, and a new friendship with a handsome classmate that could change everything
Stars: Joey King, Joel Courtney, Jacob Elordi, Molly Ringwald, Taylor Zakhar Perez, Maisie Richardson-Sellers, Meganne Young, Stephen Jennings, Carson White, Bianca Bosch, Camilla Wolfson, Zandile Madliwa, Judd Krok, Sanda Shandu, Hilton Pelser, Frances Sholto-Douglas, Evan Hengst, Joshua Daniel Eady
A young ex-communicated seminarian, Ike "Vikar" Jerome, arrives in Los Angeles on the same August day in 1969 that a crazed hippie ''family'' led by Charles Manson commits five savage murders.
Stars: James Franco, Megan Fox, Seth Rogen, Joey King, Jacki Weaver, Dave Franco, Craig Robinson, Vince Jolivette, Scott Reed, Gus Van Sant, Danny McBride, Mike Starr, Marc-Edouard Leon, Nick Buda, Jack Kehler, Tyler Danna, Mia Serafino, Jason Fox
Battle: Los Angeles
A squad of U.S. Marines becomes the last line of defense against a global invasion.
Stars: Aaron Eckhart, Michelle Rodriguez, Bridget Moynahan, Ramon Rodriguez, Will Rothhaar, Cory Hardrict, Jim Parrack, Gino Anthony Pesi, Ne-Yo, James Hiroyuki Liao, Noel Fisher, Adetokumboh M'Cormack, Bryce Cass, Michael Peña, Neil Brown Jr., Taylor Handley, Joey King, Lucas Till
White House Down
While on a tour of the White House with his young daughter, a Capitol policeman springs into action to save his child and protect the president from a heavily armed group of paramilitary invaders.
Stars: Channing Tatum, Jamie Foxx, Maggie Gyllenhaal, Jason Clarke, Richard Jenkins, Joey King, James Woods, Nicolas Wright, Jimmi Simpson, Michael Murphy, Rachelle Lefevre, Lance Reddick, Matt Craven, Jake Weber, Peter Jacobson, Barbara Williams, Kevin Rankin, Garcelle Beauvais
Paranormal investigators Ed and Lorraine Warren work to help a family terrorized by a dark presence in their farmhouse.
Stars: Patrick Wilson, Vera Farmiga, Ron Livingston, Lili Taylor, Shanley Caswell, Hayley McFarland, Joey King, Mackenzie Foy, Kyla Deaver, Shannon Kook, John Brotherton, Sterling Jerins, Marion Guyot, Morganna Bridgers, Amy Tipton, Kymoura Kennedy, Sean Flynn, Ashley White
A 16-year-old girl and her extended family are left reeling after her calculating grandmother unveils an array of secrets on her deathbed.
Stars: Joey King, Paul Scheer, Andrea Savage, Jack Kilmer, June Squibb, Kelly Lamor Wilson, Erin Darke, Logan Medina, Stephen Ruffin, Rick Andosca, Bill Eudaly, Elise DuQuette, Nick Caruso, Jared Gray, John Weselcouch, Paul Ryden, Melissa Youngblood, Morgan Savoy
A look at the trials and tribulations of the Compson family, living in the deep south during the early part of the 20th century.
Stars: James Franco, Tim Blake Nelson, Scott Haze, Loretta Devine, Ahna O'Reilly, Joey King, Jacob Loeb, Janet Jones, Dwight Henry, Logan Marshall-Green, Jim Parrack, Kylen Davis, Brady Permenter, Stella Allen, Cody Farr, Jacob Skirtech, Shawntae Hughes, Keegan Allen
Ice Age: Dawn of the Dinosaurs
When Sid's attempt to adopt three dinosaur eggs gets him abducted by their real mother to an underground lost world, his friends attempt to rescue him.
Stars: Ray Romano, John Leguizamo, Denis Leary, Eunice Cho, Karen Disher, Harrison Fahn, Maile Flanagan, Jason Fricchione, Bill Hader, Kelly Keaton, Joey King, Queen Latifah, Allegra Leguizamo, Lucas Leguizamo, Clea Lewis, Jane Lynch, Josh Peck, Simon Pegg
A struggling actor, father and husband finds himself at a major crossroads, which forces him to examine his life, his family and his career.
Stars: Zach Braff, Joey King, Pierce Gagnon, Kate Hudson, Alexander Chaplin, Leslie David Baker, James Avery, Ato Essandoh, Jim Parsons, Mark Thudium, Mandy Patinkin, Josh Gad, Allan Rich, Ashley Greene, Michael Weston, Cody Sullivan, Bruce Nozick, Matt Winston
Outlaw Prophet: Warren Jeffs
The true story of a Fundamentalist Mormon leader who spent more than a year on the FBI's "10 Most Wanted List" for unlawful flight on charges related to his alleged arrangement of illegal marriages involving underage girls.
Stars: Tony Goldwyn, Molly Parker, Joey King, David Keith, Martin Landau, Sabina Gadecki, Barbie Robertson, Alex Knight, Jacob Dacus, Jenny Gabrielle, Aaron McPherson, Bryan Chatlien, Thom Hallum, Victor Talmadge, Jason Douglas, Eb Lottimer, Jackamoe Buzzell, Will Buchanan
36 Saints
When New York Police Headquarters is confronted with the horror of a serial murderer loose on the streets of Manhattan. Oblivious to the danger, a group of hip students from all over the world, who now attend school together in Ne...
Stars: Franky G, Jeffrey De Serrano, Donna McKechnie, Jamie Tirelli, Britne Oldford, Tyrone Marshall Brown, Matthew Daddario, Aja Naomi King, Chris Riggi, Alesandra Assante, Allan Louis, Laverne Cox, Raul Casso, Mihaela Kolich, Joey Dedio, Maya Days, Dominic Colón, Frances Lozada
When her family misses her jump roping competition, a 16-year-old girl and her siblings hold their parents hostage, hoping to correct their unsatisfying behavior.
Stars: Kristin Chenoweth, Matthew Modine, Olesya Rulin, Joey King, Shirley Jones, Eddie Hassell, Chloe Bridges, Adam Saunders, Robbie Tucker, Peter Gail, Chase Yi, Lauren LaStrada, Paul Black, Cindy Chang, Lynn Anderson, Marc Bowers, Arthur Cartwright, Patricia Lynne Cissell
A small-time magician is swept away to an enchanted land and is forced into a power struggle between three witches.
Genre: Adventure, Family, Fantasy
Stars: James Franco, Michelle Williams, Rachel Weisz, Mila Kunis, Zach Braff, Bill Cobbs, Joey King, Tony Cox, Stephen R. Hart, Abigail Spencer, Bruce Campbell, Ted Raimi, Tim Holmes, Toni Wynne, Rob Crites, William Dick, Gene Jones, John Lord Booth III
Five assassins aboard a fast moving bullet train find out their missions have something in common.
Stars: Joey King, Karen Fukuhara, Brad Pitt, Zazie Beetz, Sandra Bullock, Aaron Taylor-Johnson, Michael Shannon, Logan Lerman, Hiroyuki Sanada, Pasha D. Lychnikoff, Brian Tyree Henry, Bad Bunny, Emelina Adams, Andrew Koji, Masi Oka, Johanna Watts, Andrea Muñoz, Rebecca Lynne Morley
Ramona and Beezus
An adventurous young girl uses her imagination to escape her reality, that is quickly spinning out of reach.
Stars: Joey King, Selena Gomez, Bridget Moynahan, John Corbett, Ginnifer Goodwin, Josh Duhamel, Jason Spevack, Sierra McCormick, Sandra Oh, Kathryn Zenna, Janet Wright, Ruby Curtis, Hutch Dano, Patti Allan, Garnet Harding, Daniel A. Vasquez, Andrew McNee, Tom Pickett
Elevator Girl
Modern Cinderella-romance where a young successful lawyer panics when he finds that he has fallen for a working-class girl.
Stars: Lacey Chabert, Ryan Merriman, Hedy Burress, Jonathan Bennett, Patty McCormack, Allison McAtee, Joey King, Tanja Reichert, Benton Jennings, Jeanette Miller, Sean McGowan, Edith Jefferson, Nick LaTour, Suzan Brittan, Priscilla Barnes, Jerald Garner
Avenging Angel
A preacher (Sorbo) becomes a bounty hunter after a group of refugees seeking shelter in his church is murdered by a gang of ruthless outlaws.
Stars: Kevin Sorbo, Nick Chinlund, Cynthia Watros, Richard Lee Jackson, Lorin McCraley, Wings Hauser, Joey King, Jim Haynie, Jack Riley, Sam Sorbo, Willow Geer, Dennis Fitzgerald, Tom O'Keefe, Brandon Parrish, Van Epperson, David Wells, Earl H. Bullock, Bobbie Stamm
When a strong-willed princess refuses to wed the cruel sociopath, she is kidnapped and locked in a remote tower of her father's castle. With her vindictive suitor intent on taking her father's throne, the princess must save the ki...
Genre: Action, Drama, Fantasy
Stars: Joey King, Olga Kurylenko, Antoni Davidov, Radoslav Parvanov, Ludmil Kehayov, Katelyn Rose Downey, Alex Reid, Ed Stoppard, Kristofer Kamiyasu, Fergus O'Donnell, Ivan Vodenicharov, Mitko Angelov, Apostol Tenev, Dominic Cooper, Vasil Toshev, Dawn Sherrer, Veronica Ngo, Lyubomir Neikov
Crazy, Stupid, Love.
A middle-aged husband's life changes dramatically when his wife asks him for a divorce. He seeks to rediscover his manhood with the help of a newfound friend, Jacob, learning to pick up girls at bars.
Stars: Steve Carell, Ryan Gosling, Julianne Moore, Emma Stone, Lio Tipton, Jonah Bobo, Joey King, Marisa Tomei, Beth Littleford, John Carroll Lynch, Kevin Bacon, Liza Lapira, Josh Groban, Mekia Cox, Julianna Guill, Zayne Emory, Crystal Reed, Joanne Brooks
A television reporter and her cameraman are trapped inside a building quarantined by the CDC, after the outbreak of a mysterious virus which turns humans into bloodthirsty killers.
Genre: Horror, Sci-Fi, Thriller
Country: Spain, United States
Stars: Jennifer Carpenter, Steve Harris, Columbus Short, Jay Hernandez, Johnathon Schaech, Andrew Fiscella, Rade Serbedzija, Greg Germann, Bernard White, Dania Ramirez, Elaine Kagan, Marin Hinkle, Joey King, Jermaine Jackson, Sharon Ferguson, Denis O'Hare, Stacy Chbosky, Jeannie Epper


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☀R U My Moon? 🌚 Are you my moon? If so we probably can't exist Everywhere we go From where we leave We will be missed A promise That we must fulfill You reflect my light even if against your will Maybe When it all disappears It'll erase the pain And we can get away from here. Short little poem, hope you guys find some meaning in it. Have a nice day ✌🏾🐺.


text:
NEWSFLASH: Dexcom Acquires TypeZero Tech and Automated Insulin Delivery Algorithm!
Written by Mike Hoskins — Updated on August 26, 2018
It's happening, Folks: Dexcom has officially stepped beyond just continuous glucose monitoring with data-sharing to become an active purveyor of closed loop technology that will automate insulin delivery.
The highly successful California CGM company on Aug. 22 announced the acquisition of Virginia-based startup TypeZero Technologies, founded in 2015 as a spin-off of University of Virginia closed loop technology research. TypeZero is developing what it calls the InControl system (formerly named the DiA, or Diabetes Assistance), a control algorithm run on a smartphone app that communicates with an insulin pump and CGM to automatically adjust basal and bolus insulin as needed when a hypo or high blood sugar is predicted.
By making this acquisition, Dexcom becomes a full-fledged player in the race to create an Artificial Pancreas system, rather than simply a provider of one key component (CGM).
A "Plug-and-Play" Diabetes Closed Loop System
One of the major advantages of this system is that from the start it's been designed to be pump and CGM "agnostic," meaning it wouldn't lock users into any specific product brand. Dexcom confirms that it will continue in this vein, and will not be pushing a Dexcom CGM or any particular pump model to eventual customers of this system.
Instead, they imagine a world of "plug-and-play" diabetes tech — where you can choose devices and tools that work best for you, instead of being locked into one CGM, pump or smart pen, or any pre-packaged set of products. Now, Dexcom will just happen to own one of the algorithms.
"This creates just the opposite of locking people in, it opens up so much opportunity," says JDRF Chief Mission Officer Aaron Kowalski, who's been a leader in ushering in Artificial Pancreas development for more than a decade now. "You're going to see more options."
With this latest news, Dexcom and TypeZero say they'll have a first-gen InControl system in 2019 — utlizing a Tandem t:slim X2 insulin pump, since that company has partnered with TypeZero since 2016 in developing a configuration dubbed the Control-IQ. It can automatically shut off insulin when a low is predicted, as well as auto-adjust with boluses to bring down high blood sugars. That's a step beyond the Basal-IQ system that Tandem just recently launched in August 2018, and Tandem has confirmed launch plans for its hybrid closed loop with the InControl algorithm in early 2019.
Impact of the Dexcom-TypeZero Acquisition
TypeZero execs unsurprisingly referred questions to the new parent company. There we spoke with Dexcom's VP of Corporate Development Matt Dolan, who tells us TypeZero's current location in Charlottesville, VA, will stay intact and become Dexcom's first in-house R&D group in that state. The team is already quite familiar with Dexcom CGM tech and that "will help us accelerate a number of important efforts in our product pipeline," Dolan says.
When asked about the timing of this acquisition, Dolan said: With FDA's approval earlier this year of the Dexcom G6 as a first-of-its-kind with "iCGM" designation, allowing for the G6 to be used with other connected D-tech more easily, this TypeZero acquisition "fits right into our broader strategy and drive toward interoperability."
We also asked whether this might be Dexcom's first step toward buying an insulin pump company (like Tandem), in order to eventually develop its own proprietary Automated Insulin Delivery system?
"No, this is not a signal that we are entering the pump space. This provides an opportunity to bring more options to both insulin delivery partners and patients, including AID algorithms as well as decision support tools," Dolan says.
"We will continue to support partnerships with the same level of commitment we have had to date, and we don't have a bias toward our AID algorithm. The goal of our open platform is to commercialize many great options to manage diabetes, which is in the best interest of patients."
The Diabetes Tech Industry Responds
When it comes to developing advanced diabetes tools, you almost need a family tree chart to keep track of who's teamed up with who these days, and it's constantly evolving.
Over the past few years, TypeZero has partnered Dexcom and Tandem; with Cellnovo on a version using that hybrid patch pump; with Senseonics using their implantable Eversense CGM; and with the EOFLow patch pump in Asia.
Meanwhile, Dexcom has partnered with AID system developers like Beta Bionics for the iLet; with Eli Lilly and Novo and Sanofi on their future D-tech; and with Insulet on the OmniPod Horizon closed loop system that will use the algorithm being developing by Bay Area startup ModeAGC.
So what do all these other players think about Dexcom's move to acquire TypeZero? We reached out to a number of them for reactions:
Tandem: "The terms of our agreement with TypeZero are not impacted by the Dexcom acquisition and we look forward to continue working with them," spokesman Steve Sabicer said. "Dexcom's acquisition of TypeZero has no impact on the terms of our existing agreements with either company."
Insulet / OmniPod: "This news will not impact our relationship with Dexcom or any of the projects we are working on with them," said Natalie Montgomery, Insulet's marketing manager for global PR and field programs.
Bigfoot Biomedical: The startup's president Bryan Mazlish says, "Bigfoot has been advocating for closer integration of diabetes technologies into systems for many years and we're excited to see Dexcom and TypeZero moving in this direction. We believe systems, such as what we are developing here at Bigfoot, are the future of diabetes technology and will best serve patients and providers in the years to come."
Beta Bionics: ""Beta Bionics is excited for Dexcom's ongoing commercial success with G6 setting the iCGM standard. We are extremely proud to have a close and longstanding partnership with Dexcom," says VP of Business Development Ed Raskin. "Dexcom has confirmed to us and in public comment that it has no intention of competing directly with the Beta Bionics iLet bionic pancreas system, or any of Dexcom's other insulin pump partners. We also do not see the TypeZero algorithm as competitive with the Beta Bionics approach to automated glucose control."
Cellnovo: "This is big news for the industry and we see it as a positive development for our current partnership with TypeZero," says Cellnovo's Communications and Digital Marketing Director Bommy Lee. "As a reminder, we signed a commercial agreement with TypeZero in April 2017 to integrate their InControl algorithm into our automated insulin delivery system, which is now set for an initial clinical trial in Europe."
Senseonics: "Integrated automated insulin delivery systems are an important development for people with diabetes, which is why Senseonics is pleased to have partnered with TypeZero Technologies on the NIH-funded IDCL program and, more recently, with Beta Bionics on its own artificial pancreas program," said Mirasol Panlilio, VP and general manager of global commercial at Senseonics. "As (this) acquisition announcement is very recent news, Senseonics is working through the details with the companies to determine how this new development will affect the TypeZero licensing agreement moving forward."
And don't forget: Medtronic has acquired an algorithm from Israeli startup DreaMed for its future fully closed loop systems in the pipeline, while Abbott has partnered with Bigfoot in using a future-generation of the Libre Flash monitoring system in Bigfoot's system. The Big Three insulin makers Lilly, Novo and Sanofi also have their eyes on AID systems, as well a number of smaller new CGM developers gunning to get their new products to market.
It's also important to note that with all of these algorithm-agreements, not all are going to turn out the same way. Each company buys the right to use and further develop that basic algorithm, meaning by the time a product actually gets to market it won't be the exact same TypeZero algorithm as what was purchased. Think of it like buying a house: You buy the basic model, but each one varies with different looks, appliances, doors and cabinet knobs. That's how the APs will evolve, too.
As the saying goes in so many things diabetes medtech, "the race is on"…
High Praise from JDRF
Kowalski at the JDRF, a fellow T1D himself who's had his finger on the pulse of this closed loop and AID universe for years now, has high praise for this latest development. He points out JDRF has funded TypeZero's research from its early days at UVA.
"Having a vehicle to get the technology from these algorithm research groups out to people has been a challenge over the years. But now only recently, we're starting to see the technology getting to the commercial space. To see TypeZero get picked up by Dexcom is great," he says.
Keeping in touch with PWDs involved in the TypeZero-Tandem clinical trials, Kowalski says he's heard that system described as "off-the-charts good" and "life-changing."
He's also excited about seeing Dexcom lay more ground work for a "plug-and-play" world, where PWDs can mix and match various devices and tools.
"What if you could just plug in algorithms with whatever pump or CGM you're using?" he mused. "Dexcom has the ability to potentially talk to so many different pumps or smart pens, and algorithms that can be plugged in… wow! That's the difference here. We're seeing it… opening up a lot of interesting possibilities."
So overall, this acquisition is looking like a very good thing for all parties involved.
Many agree it's a brilliant move on Dexcom's part, positioning them to be leaders in future connected systems, beyond just creating the world's most popular CGM.
Will they eventually take the next step and get into the insulin pump business? That's a lot more expensive and risky of course.
We're just delighted that for now, the focus is getting reliable automated systems into the hands of as many people with diabetes as possible, as soon as possible. We thank them for that.
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