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Integrative Assessment of Adult Personality, Third Edition
by Harwood, T. Mark; Beutler, Larry E.; Groth-Marnat, Gary
Publisher(s): The Guilford Press
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A complete, thorough, and pragmatic guide to clinical assessment, this authoritative book meets a key need for both students and practitioners. The authors describe how to construct a "moving picture" of each patient by integrating data from a variety of sources. Included are detailed, systematic reviews of widely used instruments together with strategies for selecting the best methods for particular referral questions. Readers learn to conduct integrated assessments that take the complexities of the individual personality into account, serve as the basis for developing an effective treatment plan, and facilitate meaningful reporting and client feedback. New to this edition: incorporates the latest research findings and assessment/treatment planning tools chapters on the Personality Assessment Inventory and the NEO-PI-R and NEO-PI-3 a new extended case example runs throughout the chapters critically evaluates the recently published MMPI-2-RF.
T. Mark Harwood, PhD, is the former Director of Clinical Training and Core Faculty in Wheaton College's Doctoral Program in Clinical Psychology. He has had extensive experience as a clinician, investigator, faculty member, and administrator, and has published widely in professional journals and textbooks, with a primary focus on psychotherapy outcome research. He is currently in private practice in St. Charles, Illinois. Larry E. Beutler, PhD, is the William McInnes Distinguished Professor and former Chair of the PhD Programs at Palo Alto University's Pacific Graduate School of Psychology. He is also Consulting Professor of Psychiatry and Behavioral Sciences at Stanford University School of Medicine. Dr. Beutler is a Fellow of the American Psychological Association and the American Psychological Society and is the author of 23 books and over 400 scholarly papers and chapters. Gary Groth-Marnat, PhD, ABPP, ABAP, is Professor of Clinical Psychology at Pacifica Graduate Institute and a psychologist in private practice in Santa Barbara, California. He is the author of 150 chapters/journal articles and four books. Dr. Groth-Marnat is a Fellow of the American Psychological Association (Division 12), Fellow of the Society for Personality Assessment, Diplomate of the American Board of Professional Psychology, Diplomate of the American Board of Assessment Psychology, and recipient of numerous awards.
1. Introduction to Integrative Assessment of Adult Personality, Larry E. Beutler, Rita Rosner, Gary Groth-Marnat, T. Mark Harwood, and Hui-Qi Tong 2. Approaching the Patient: Referral Contexts, Test Selection, and Clinical Judgment, Gary Groth-Marnat, Larry E. Beutler, T. Mark Harwood, and Lisa Joseph 3. Identifying Treatment-Relevant Assessment: Systematic Treatment Selection/InnerLife, T. Mark Harwood, Larry E. Beutler, Oliver B. Williams, and R. Scott Stegman 4. The Integrative Clinical Interview, Paulo Machado, Larry E. Beutler, T. Mark Harwood, David Mohr, and Samarea Lenore 5. Integrating Intelligence and Personality, Elizabeth J. Austin, Gregory J. Boyle, Gary Groth-Marnat, Gerald Matthews, Donald H. Saklofske, Vicki L. Schwean, and Moshe Zeidner 6. The MMPI-2, James N. Butcher, Larry E. Beutler, T. Mark Harwood, and Kathy Blau 7. The Personality Assessment Inventory, Leslie C. Morey, Sara E. Lowmaster, T. Mark Harwood, and Daniel Pratt 8. The Millon Clinical Multiaxial Inventory-III, Paul D. Retzlaff, Thomas Dunn, and T. Mark Harwood 9. The NEO Inventories, Robert R. McCrae, T. Mark Harwood, and Sarah L. Kelly 10. The Rorschach and Performance-Based Assessment, Radhika Krishnamurthy, Robert P. Archer, and Gary Groth-Marnat 11. Integrative Personality Assessment in Special Settings, Gary Groth-Marnat, Ronald A. Stolberg, Bruce Bongar, and Keith Burke 12. Integrative Personality Assessment with Older Adults and Ethnic Minorities, Martha R. Crowther, Audrey L. Austin, Forrest Scogin, T. Mark Harwood, and Sean Harrell 13. Applying Assessment Information: Decision Making, Patient Feedback, and Consultation, Richard W. Levak, R. Sean Hogan, Larry E. Beutler, and Xiaoxia Song 14. The Integrated Psychological Report, Steven Kvaal, James Choca, Gary Groth-Marnat, and Ari Davis Appendix A. Test Scores for D. K. by Chapter Appendix B. Test Publishers/Distributors Appendix C. Systematic Treatment Selection Analysis


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What kind do you use for machine quilting? Do you like it?
Are you looking to buy a new machine?
Bernina 440QE with the BSR. Only thing I don't like is that it doesn't have an enormous throat (think that is the term used for the space through which you would yank a quilt when quilting). Is more expensive than other machines but think it is built to last. Before that had two different types of basic Brother machines and to compare them with a Bernina would be like night and day!
I quilt on a Juki TL-98E on a Hinterberg frame with Quilter's Cruise Control. I piece on a Janome 6600P.
Singer Confidence Quilter and No... I do not like machine quilting on it. I haven't tried another machine so I don't know if it's me or the machine. I'm kinda afraid to find out!
I use my Pfaff for everything. We noticed a new one with a much longer throat area, but I'm still pretty happy 5 years after getting this machine.
Tonnes of long arms available at Quilt Canada this week! I just walk right by.
I have an Elna 7200. I'm sure it would do a splendid job of machine quilting...if I really gave it a chance. First I have to try something other than straight-line quilting. It has a nice big throat area though.
We have an APQS Millennium drive by my hubby. If I absolutley have to domestic quilt, I prefer my Janome 6500 over my Pfaff QE 4.0.
Just my short and sweet two cents. Are you going down to Calgary for Quilt Canada?
I have an Elna 7200. It is awesome and I can't recommend it enough.
Brother Innovis QC 1000 with a longer throat area, I love it!


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This weekend in ENC
Emerald Isle Parks and Recreation Community Center will host a four on four Volleyball Tournament on Jan. 26 beginning at 8 a.m.
CAPE CARTERET � Mac Daddy�s Entertainment Center will host the third annual Winter Festival on Jan. 26 from 10 a.m. to 5 p.m. Booths with arts and crafts, jewelry, clothing, beauty products, home d�cor and local fire and police departments will be available to visit along with live entertainment performing throughout the day. Face painting, cake walks and games will be available for children. Mac Daddy�s is located at 126 Golphin Dolphin Drive. For more information, visit mymacdaddy�s.com or call 252-393-6565.
EMERALD ISLE � Emerald Isle Parks and Recreation Community Center will host a four on four Volleyball Tournament on Jan. 26 beginning at 8 a.m. This is a "coed" tournament and players must be at least 16 years old. Pre-registration is required (no game day registration). Registration deadline is Friday before game day at 5 p.m. Team fee is $55 per team with prize money going to the top two teams (70 percent to first place; 30 percent to second place). Tournament capacity is six teams. Teams must bring their own ball and will act as officials when not playing. Note: officiating may be required after elimination FIVB rules apply. For registration, payment and general information, contact Emerald Isle Parks & Recreation at 252-354-6350.
JACKSONVILLE � The Athletics Recreation and Parks Department will be hosting a Men�s 18+ open and Women�s 18+ Open Futsal Tournament Jan. 26-27 at the Jacksonville Commons Recreation Gym. It will be a three game guarantee and $125 per team. Limited teams. Last day to sign up is Jan. 23. For more information, contact Jacksonville Recreation and Parks Department at 910-938-5268 or the city web site at ci.jacksonville.nc.us under Recreation.

redpajama_set_name: RedPajamaCommonCrawl


Cookies. Cupcakes. Pumpkin seeds. Popcorn balls. Punch. Find cute or creepy goodies to feed your Halloween fun.
These scary-good recipes will haunt your dreams of dinner!
Get recipes and decorating ideas for hand-held bites of boo.
These cute and creepy dinners are too delicious to resist.
Fresh pumpkin seeds are roasted with butter in salt to make this popular seasonal snack.
Tasty little cookie and candy snacks look just like pointy witch hats. They are so easy a kid can help. Little bows made from decorating gel add to their spooky effect.
Toasted and salted, pumpkin seeds have a nutty flavor. Seasoned with sweet and savory spices, they're even better.


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Bleaching 0%
Siaba Besar, Komodo National Park on 31 Oct, 2019
Green Turtle
The green sea turtle (Chelonia mydas), also known as the green turtle, black (sea) turtle, or Pacific green turtle, is a large sea turtle of the family Cheloniidae. It is the only species in the genus Chelonia. Its range extends throughout tropical and subtropical seas around the world, with two distinct populations in the Atlantic and Pacific Oceans. The common name comes from the usually green fat found beneath its carapace. This sea turtle's dorsoventrally flattened body is covered by a large, teardrop-shaped carapace; it has a pair of large, paddle-like flippers. It is usually lightly colored, although in the eastern Pacific populations parts of the carapace can be almost black. Unlike other members of its family, such as the hawksbill sea turtle, C. mydas is mostly herbivorous. The adults usually inhabit shallow lagoons, feeding mostly on various species of seagrasses. Like other sea turtles, green sea turtles migrate long distances between feeding grounds and hatching beaches. Many islands worldwide are known as Turtle Island due to green sea turtles nesting on their beaches. Females crawl out on beaches, dig nests and lay eggs during the night. Later, hatchlings emerge and scramble into the water. Those that reach maturity may live to eighty years in the wild. C. mydas is listed as endangered by the IUCN and CITES and is protected from exploitation in most countries. It is illegal to collect, harm or kill them. In addition, many countries have laws and ordinances to protect nesting areas. However, turtles are still in danger because of several human practices. In some countries, turtles and their eggs are hunted for food. Pollution indirectly harms turtles at both population and individual scales. Many turtles die caught in fishing nets. Also, real estate development often causes habitat loss by eliminating nesting beaches.
Bleaching occurs when corals expel their symbiotic zooxanthellae - pigmented, algae-like protozoa that live within the coral's cells. High temperature, pollution or other stresses can cause the coral to expel its zooxanthellae, leading to a lighter or complete loss of color.


Find new and used equipment for sale, massage services and products in Washington. Create a free photo classified ad for items you want to advertise.
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The 8th annual Rusk County Singing met Saturday before the fourth Sunday in April at Old Pine Grove Church near Henderson, Texas. The tune book for Saturday was the 2010 Revision of the Christian Harmony. With the absence of the chairman and the vice chairman, Secretary Gaylon Powell called the class to order leading 206. Chris Nicholson offered the opening prayer. Gaylon Powell then called the class into a business session and the following officers were elected: Chairman - Mike Hinton; Vice Chairman - Chris Nicholson; Secretary - Gaylon Powell.
Leaders: Gaylon Powell 264; Mike Hinton 303, 143; Chris Nicholson 398t, 399b; Robert Vaughn 221b, 142; Kristie Powell 258, 339; Carole Watts 189, 298; Natalie Fletcher 188, 131.
Mike Hinton called the class back together leading 86t. Leaders: Henry McGuire 86b, 168b; Charity Vaughn 29, 284; Chris Nicholson 338t, 338b; Gaylon Powell 155, 336t; Robert Vaughn 299, 361; Kristie Powell 41t, 548; Natalie Fletcher 367, 226t. Dismissed for lunch with Henry McGuire asking the blessing at the dinner tables.
Mike Hinton called the class back together leading 70b and 291. Leaders: Henry McGuire 422b, 432b; Chris Nicholson 346, 347; Gaylon Powell 137, 136; Robert Vaughn 40, 71; Kristie Powell 105t, 332; Carole Watts 382, 82t; Henry McGuire 460t, 64.
Mike Hinton called the class back together leading 349 and 179. Leaders: Kim Vaughn 253, 149, 329; Chris Nicholson 67b, 76b; Gaylon Powell 256t, 259t; Robert Vaughn 222t, 316; Kristie Powell 138, 493b; Henry McGuire 493t, 246. Mike appointed Kristie Powell and Charity Vaughn to serve on the memorial committee. Mike Hinton led 30b for the closing song. The closing prayer was offered by Robert Vaughn.
The Sunday session of the convention was held in conjunction with the Pine Grove Cemetery Homecoming. The tune book for Sunday was the Cooper Revision of the Sacred Harp. Mike Hinton called the class to order leading 31b. David Rousseau led the opening prayer. Leaders: Mike Hinton 293b; Gaylon Powell 203, 300; Kim Vaughn 558, 507b; Henry McGuire 567, 133; David Rousseau 127, 72; Will McGuire 392, 484b; Chris Nicholson 32t, 31t; Charity Vaughn 489, 73t; Kristie Powell 210, 524.
Mike Hinton called the class back together leading 138t. Leaders: Carole Watts 461, 40; Sherry Rousseau 572, 573; Robert Vaughn 314, 38t; Chris Nicholson 508, 507t; Gaylon Powell 522, 486; Henry McGuire 458, 594.
Memorial Lesson: Charity Vaughn read the names of the sick and shut-ins: Curtis and Edith Owen, Myrl Jones, Leo and Mary Stanley, Amy Denison, Cheryl Foreman, Ruth Redmon, Dale Redmon, Jr., Adelaide Vaughn - Texas; Susan Harcrow, and Toney and LaVuy Smith - Alabama; Janelle Davis - Illinois; Alice McGuire - Mississippi. She made some comments and led 540 in their honor.
Kristie Powell read the names of the deceased: HP O'Mary and Bill Burnes - Texas; George Easley and Charles Porter - Mississippi; Robert Dupree - Alabama; Oliver Stokes - Pennsylvania; Donald Klein and John Schaffer - Colorado; Leonard Singletary - Burials in the Pine Grove Cemetery She made some comments and led 285t in their honor.
Mike Hinton called the class back together leading 87 and 369. Leaders: Kristie Powell 514, 273; Kim Vaughn 528b, 467; David Rousseau 563, 341; Charity Vaughn 422b, 411; Carole Watts 340, 501; Robert Vaughn 423, 47b; Will McGuire 410, 465. It was agreed that as of next year, the Sunday session will begin at 9:30 a.m. After announcements, Mike Hinton led 511t for the closing song. The convention closed with prayer by Gaylon Powell.


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Capsule Reviews: Argo, Beasts of the Southern Wild, Seeking a Friend for the End of the World
Even though I'm a serious movie fan, there's rarely enough time to check out all the films that interest me when they originally hit the theaters. I recently did a 2012 Catch-Up Marathon to fill this gap, but that only scratched the surface of the worthy choices from this year. After checking out three releases during the past week, I've decided to write short reviews to summarize my thoughts. Each movie has a lot going for it, and several will certainly be heard from during the awards season. I'm curious to hear your reactions too; let me know what you thought about these films in the comments section!
Argo (Ben Affleck)
Ben Affleck has earned great acclaim for his directing in Gone Baby Gone and The Town, but he takes a big step up with Argo. This adaptation of the true-life experiences of six hostages trapped in Iran and the man who rescued them is a gripping thriller. Affleck plays Tony Mendez, a CIA expert at this seemingly impossible situation. His idea of using the cover of shooting a sci-fi movie is genius because it's so ridiculous. John Goodman and Alan Arkin are charming as the Hollywood guys who support the scheme and sell the picture. Considering the heavy material in Iran, the spoof on the movie industry provides a welcome respite. The tone is different but doesn't feel out of place. Affleck has good chemistry with both of the veteran actors, and their bond lifts the story beyond a typical spy movie.
The hostages include a talented group of youngsters who are virtually unrecognizable behind '70s hair and clothes. Scoot McNairy (Monsters) gets the most to do as the skeptic, but it's the stable presences of Tate Donovan and Clea DuVall that make us care about their survival. Since we already know the ultimate outcome, it's up to Affleck and Writer Chris Terrio (Heights) to keep us engaged. They certainly stretch the reality to ratchet up the tension, but it rarely feels manipulative. The set design sells the idea that we're seeing Iran in 1979 because it seems down to earth. It's clear that Affleck is trying to mirror '70s classics like All the Presidents Men while still entertaining modern audiences. While it isn't my favorite movie of the year, I wouldn't complain if Argo received a Best Picture nomination. Everyone involved gives it their all and delivers a highly engaging thriller.
Beasts of the Southern Wild (Benh Zeitlin)
Released in July, Benh Zeitlin's debut feature earned tremendous acclaim and should be on many year-end lists. I hesitated to check it out because of false expectations of its content. Those assumptions were generally untrue and missed the strangely upbeat tone. The characters are living in serious poverty in the Louisiana bayou, yet it's rarely depressing. Quvenzhané Wallis is completely believable as the six-year-old Hushpuppy, who lives with her father Wink (Dwight Henry). When a massive storm arrives, it devastates the "bathtub" community and nearly washes away their lives. We stick with Hushpuppy as she tries to survive with other residents while Wink suffers from an even tougher situation. Stricken with an illness that isn't going away, he battles to stay independent against poor odds.
Beasts of the Southern Wild is a challenging film to discuss because there's so much happening on screen. Beyond presenting the central plot, Zeitlin is showing the destruction of nature. This disaster is depicted symbolically through the "Aurochs", massive prehistoric creatures formerly trapped in the Arctic ice. They appear frequently and even interact with Hushpuppy, which pulls the story more into fantasy territory. While providing more depth into what Zeitlin's trying to say, it also feels less intimate than the main story. The images are gorgeous throughout the movie, even when we're trapped inside the decrepit homes. It's a striking debut from a filmmaker to watch in the next few years. Another highlight is the work of Dwight Henry, a New Orleans bakery owner discovered by chance by the crew. He never strikes a false note as Wink and brings a captivating energy to the fiery character.
Seeking a Friend for the End of the World (Lorene Scafaria)
The impending apocalypse isn't the typical set-up for a comedy, but most of Seeking a Friend for the End of the World plays out like a fun road movie. Steve Carell plays his stock character of the middle-aged guy disenchanted with life. His wife runs out (literally) on him when they learn that the world is ending in several weeks. By chance, he starts a journey with Penny (Keira Knightley), and they strike up a friendship. After avoiding the doom of a crazy mob, they head into the country with positive goals in mind. He's searching for an old flame, and she's looking for a plane to get back home. Carell and Knightley have great chemistry, so it isn't awkward when they strike up a romance. They probably wouldn't connect in a normal world, but they find a bond among the chaos.
The strange part of this film is the drastic tonal shift in the last act. It becomes more of a standard romance where the issues would be resolved if the characters just communicated. However, this isn't fatal because the actors sell the material. They're so likable that we're willing to take the ride and want them to be together, despite the plot contrivances. Knightley is a big surprise and so refreshing when performing in a modern setting. I just want to spend time with these characters and can mostly push aside the concerns. It isn't entirely successful, but there are enough fun moments to make it worthwhile. There's a wonderfully silly scene in an Applebees-like hotel that generates some big laughs. Those oddball highlights make it worth checking out. Lorene Scafaria adapted Nick and Norah's Infinite Playlist, and she brings a similar type of wit to this directorial debut.
Labels: 2012, Film Review
sati (harlequinade) December 30, 2012 at 11:13 AM
I really liked "Seeking..." it wasn't perfect but it was quite unique and I really enjoyed Carrel's subtle performance and film's lovely ending.
I loved Argo, wasn't a big fan of Beasts, though. Solid movie but I didn't connect with it.
Dan December 30, 2012 at 2:57 PM
Sati, I feel like Beasts is such a tricky movie that I can't really argue if someone loves it or hates it. I enjoyed it despite a few minor reservations. Seeking has such engaging performances that they're able to overcome some issues. Thanks!


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Biografia

Nacque nel 1362 a Firenze, figlio del mercante Antonio Ridolfi (morto nel 1385), discendente del capostipite Ridolfo e proveniente dalla Val di Pesa, attivamente impegnato nella politica fiorentina nel partito dei guelfi e per questo più volte perseguitato, fino a essere esiliato.

Lorenzo studiò dapprima arti liberali a Firenze, avendo tra i suoi insegnanti Coluccio Salutati e appassionandosi agli autori classici e ai libri rari; frequentò quindi l'Università di Bologna per circa sei anni a partire dal 1381, assistendo alle lezioni dei maestri del diritto canonico dell'epoca tra cui Gaspare Calderini, Giovanni Fantuzzi, Giovanni da Legnano e in particolare il successore di quest'ultimo, Lorenzo di Pino. Nel 1387 conseguì il dottorato prima in diritto civile e poi in diritto canonico.

Dopo alcuni mesi, nei quali fece da lettore all'università bolognese, tornò in patria per sposare Caterina Barucci detta Pichina, in un matrimonio combinato dal fratello, e continuare a insegnare.

Dal 1393 in poi, mentre le sorti politiche ed economiche della famiglia Ridolfi si risollevavano, Lorenzo ebbe incarichi politici sempre più rilevanti: fu inviato come ambasciatore di Firenze presso papa Bonifacio IX e nel 1394 divenne priore delle Arti di Firenze, ricoprendo negli anni successivi tutte le maggiori magistrature cittadine.

Nel 1402 scrisse la sua opera più importante, il trattato De usuris et materia Montis; negli anni successivi abbandonò l'attività accademica per dedicarsi alle più remunerative consulenze. Partecipò a varie missioni diplomatiche, allo scopo di contrastare la crescente potenza del ducato di Milano ed espandere i territori di Firenze, culminate con l'alleanza stretta con la Repubblica di Venezia. Ridolfi ebbe inoltre un ruolo di rilievo nella predisposizione del Concilio di Pisa del 1409, indetto per comporre lo scisma d'Occidente.

Morì nel 1443 a Firenze.

Opere

Manoscritti

Note

Bibliografia

Voci correlate
Usura

Altri progetti

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Hip Hop Word Count
Awesome Foundation NYC's latest grant goes to the Hip-Hop Word Count by Tahir Hemphill. The Hip-Hop Word Count is a searchable ethnographic database built from the lyrics of over 40,000 Hip-Hop songs from 1979 to present day. The Hip-Hop Word Count describes the technical details of most of your favorite hip-hop songs. This data can then be used to not only figure out interesting stats about the songs themselves, but also describe the culture behind the music. How can analyzing lyrics teach us about our culture? The Hip-Hop Word Count locks in a time and geographic location for every metaphor, simile, cultural reference, phrase, rhyme style, meme and socio-political idea used in the corpus of Hip-Hop. The Hip-Hop Word Count then converts this data into explorable visualisations which help us to comprehend this vast set of cultural data. This data can be used to chart the migration of ideas and builds a geography of language. Stay tuned for details about our summer party.
Awesome Without Borders (1)
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Neutrogena Night Calming Makeup Remover Cleansing Towelettes Review | LIPS n BERRIES!
Here's to the best makeup remover wipes I've used till date. I just had to write about them. I have an OCD for squeaky clean face. I love taking every ounce of makeup off. Makeup removers and cleansing balms are all good but makeup wipes are truly a lazy girls best friend. I don't know of any girl who looks forward to taking makeup off at the end of the day. It is such a dreaded job so I'm always on a look out for things that'll make this not-so-exciting task super-quick.
Its hard to find makeup remover wipes that are perfect in every way. Some don't take off makeup that well, some itch skin, some are too harsh, some smell artificial, some don't take waterproof makeup off, some don't go well with my sensitive eyes and finally some are way too expensive.
I've found wipes that scored 10/10 on all this and more. These Night Calming Cleansing Towelettes from Neutrogena* are so good. They are super gentle on my eyes which is my number 1 priority when it comes to makeup removers of any kind. These also take off waterproof makeup pretty darn well. The cloth is super soft and well soaked and I only need 1 for the most heavy makeup look. The packaging says I don't need to cleanse my face after this which I still do because hell! there's no blogger that'll commit that sin. But I can confirm that I've spent hours after taking makeup off without washing my face and these wipes don't dry out my face at all. It actually moisturizes my face a little and skin feels super soft.
The towelettes also smell subtle and not over the top synthetic & artificial.
Do I recommend them? 100%. I'm definitely buying again. Makeup cleansing wipes are my must haves for travel because I don't have to carry bulky makeup removers. Even husband approves of them for taking sunscreen and grime off his face.
What are your favorite makeup wipes? Talk to me in the comments below.
*Product sent by brand for consideration. My views are honest as always.


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Catabasis Pharmaceuticals Presents Information on Edasalonexent, a Potential Foundational Therapy for Duchenne Muscular Dystrophy, at the Virtual 25th International Congress of the World Muscle Society
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September 28, 2020 8:00am Comments
-- New Preclinical Research Indicates that Edasalonexent Could Have Positive Effects on Cardiac Function and Preserve Bone Health --
Catabasis Pharmaceuticals, Inc. (NASDAQ:CATB), a clinical-stage biopharmaceutical company, today shared information on the edasalonexent program in Phase 3 development for Duchenne muscular dystrophy (DMD) in poster presentations at the Virtual 25th International Congress of the World Muscle Society. The posters include new preclinical research findings supporting potential positive effects on cardiac function and preservation of bone health with edasalonexent in mouse models of DMD. Information from clinical trials with edasalonexent was also presented with baseline assessments from the Phase 3 PolarisDMD trial and long-term safety results from the Phase 2 MoveDMD trial and open-label extension.
"As we approach top-line Phase 3 PolarisDMD results, which we expect to report in the fourth quarter of this year, we are pleased to share new findings from preclinical studies with edasalonexent that could support its potential as a foundational therapy for those affected by Duchenne," said Andrew Nichols, Ph.D., Chief Scientific Officer of Catabasis. "Cardiac function and bone health are critical components of Duchenne care and we are excited to learn more about these key areas that are important to patients, their caregivers and physicians."
Persistent activation of NF-kB in DMD can drive cardiac dysfunction, which is the leading cause of mortality in DMD. In a preclinical study performed in the laboratory of Pradeep Mammen, M.D., Medical Director of the Neuromuscular Cardiomyopathy Clinic and Director of Translational Research for the Advanced Heart Failure and Transplant Cardiology Program at UT Southwestern, edasalonexent prevented the development of DMD-associated cardiomyopathy in the mdx:Utrn+/- mouse model of DMD. Edasalonexent reduced the cardiac hypertrophy apparent in these mice, reduced myocardial fibrosis and prevented the development of DMD-associated cardiomyopathy.
In DMD, NF-kB activation also drives inflammation and fibrosis, leading to loss of skeletal muscle function and disease progression. Reduced skeletal muscle function results in reduced bone strength. Steroids, which activate the glucocorticoid receptor (GR), can further negatively impact bone health. In a preclinical study led by Frank Rauch, M.D., of Shriners Hospitals for Children - Canada, edasalonexent was seen to maintain bone density and bone strength in mdx mice. Consistent with these results, edasalonexent treatment in cells inhibited NF-kB and as expected did not impact the GR, while the steroid prednisolone strongly activated the GR.
Information from the edasalonexent clinical program was also presented at the Congress of the World Muscle Society. The primary endpoint of the Phase 3 PolarisDMD trial for edasalonexent is the North Star Ambulatory Assessment (NSAA), a validated measure of physical function designed for use in ambulatory boys affected by DMD. In an analysis of baseline characteristics of the patients enrolled in the Phase 3 trial (boys affected by DMD, ages 4 to 7, up to 8th birthday, not on steroids), Catabasis saw reliable and consistent NSAA scores between the two pre-treatment measures at screening and baseline, which indicate no significant learning effect between visits.
An additional evaluation of data from patients at baseline (prior to any treatment) in the Phase 3 PolarisDMD trial was shared by Leanne Ward, M.D., FRCPC, Scientific Director of Ottawa Pediatric Bone Health Research Group. This analysis showed that lean body mass index (a marker for muscle mass) was reduced in young boys affected by DMD and correlated with reduced muscle function. An analysis of the same patients was presented earlier this month at the American Society for Bone and Mineral Research 2020 Annual Conference and showed that DMD has a negative impact on bone strength, including low bone density and mild vertebral fractures at an early stage of disease course prior to any treatment.
As Catabasis has previously presented, the Phase 2 MoveDMD trial and open-label extension was also shared showing that edasalonexent was well-tolerated for up to 150 weeks and associated with favorable growth patterns. The most common related adverse effect was diarrhea, generally mild and transient.
The posters are available to registered attendees during the conference and for three months afterwards. Select posters are available in the "Our Science" section of www.catabasis.com.
About Edasalonexent (CAT-1004)
Edasalonexent (CAT-1004) is an investigational oral small molecule designed to inhibit NF-kB that is being developed as a potential foundational therapy for all patients affected by DMD, regardless of their underlying mutation. In DMD the loss of dystrophin leads to chronic activation of NF-kB, which is a key driver of skeletal and cardiac muscle disease progression. The ongoing global Phase 3 PolarisDMD trial is evaluating the efficacy and safety of edasalonexent for registration purposes. Edasalonexent is also being evaluated in the GalaxyDMD open-label extension trial. In the MoveDMD Phase 2 trial and open-label extension, the Company observed that edasalonexent preserved muscle function and substantially slowed disease progression compared to rates of change in a control period, and significantly improved biomarkers of muscle health and inflammation. The FDA has granted orphan drug, fast track, and rare pediatric disease designations and the European Commission has granted orphan medicinal product designation to edasalonexent for the treatment of DMD. For a summary of clinical results, please visit www.catabasis.com.
About Catabasis
At Catabasis Pharmaceuticals, our mission is to bring hope and life-changing therapies to patients and their families. Our lead program is edasalonexent, an NF-kB inhibitor in Phase 3 development for the treatment of Duchenne muscular dystrophy. For more information on edasalonexent and our Phase 3 PolarisDMD trial, please visit www.catabasis.com.
Any statements in this press release about future expectations, plans and prospects for the Company, including statements about the clinical program of edasalonexent, including the expected timing of release of Phase 3 data, edasalonexent potentially being a foundational therapy for DMD patients, and edasalonexent potentially having positive effects on cardiac function and preservation of bone health, along with other statements containing the words "believes," "anticipates," "plans," "expects," "may" and similar expressions, constitute forward-looking statements within the meaning of applicable securities regulations and laws. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including risks and uncertainties: inherent in the initiation and completion of clinical trials and clinical development; related to whether the results of pre-clinical studies will be predictive of results of clinical trials; related to whether the results of earlier stage clinical trials will be predictive of the results of later stage trials; related to the regulatory review and approval process; inherent in the commercialization of marketed products; related to competitive products, including those already approved and those in development; related to other matters that could affect the clinical development, regulatory status, availability or commercial potential of edasalonexent, as well as the risks and uncertainties discussed in the "Risk Factors" section of the Company's Quarterly Report on Form 10-Q for the period ended June 30, 2020, which is on file with the Securities and Exchange Commission, and in other filings that the Company may make with the Securities and Exchange Commission in the future. In addition, the forward-looking statements included in this press release represent the Company's views as of the date of this press release. The Company anticipates that subsequent events and developments will cause the Company's views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, the Company specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing the Company's views as of any date subsequent to the date of this release.
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text:
"Broadway Under The Stars" – A Fine Vintage
Art & TheaterEvents
By Jasmine Rios	 Last updated Nov 26, 2013
Artists and enthusiasts of Broadway stage are naturally well-versed in musical theatre's exhilarating effect. Given that we aim to inspire, we bring you word of a recently established dance/theatre troupe in San Francisco's North Bay (wine country), whose significance is worthy of your attention.
Enthusiasts of the performing arts have long entertained the idea of Broadway musicals performed amidst the great outdoors – wine country especially. No actually, not really. But – it was precisely this unlikely pairing that led to Transcendence Theatre Company's (TTC) stellar vintage idea, to produce "Broadway Under the Stars" in Sonoma Wine Country every summer.
Six accomplished artists, Amy Miller, Stephan Stubbins, Brad Surosky, Leah Sprecher, Randi Kaye, and Robert Petrarca, whose combined credits include Broadway, the national stage, film and television, transformed their quite literal "field of dreams" concept into a rather fruitful reality.
Artistic director/CEO Amy Miller describes TTC's philosophy: "Our Company was named after a moment in dance I call 'transcendence,' the state of feeling most alive. We are on a constant mission to create 'transcendent' experiences on stage and off that inspire our audiences to live life to the fullest."
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The troupe's venture began in 2009, as a sojourn from Broadway to Baja. During their four month theatrical residency at the Gertrude Pearlman Theatre in Punta Banda, Mexico, the artists performed for the community and worked with various orphanages and townspeople. The rewards of their practices were many, which served as a helpful model in establishing TTC.
Collectively, the troupe decided to follow a holistic approach to building and running their organization. In 2010, the artists set off on a cross-country road trip through the US in search of TTC's future home; a setting for an open-air theatre with transcendent potential.
A year passed before the troupe finally discovered the historic Jack London State Park in the heart of Sonoma Wine Country; the former home of the late author/adventurer Jack London.
What appeared to be a triumphant close to their location scouting became a short-lived dream, but only momentarily. The troupe learned that Jack London State Park was among several other parks slated for permanent closure due to state budget cuts. Initially disappointed, the troupe paused to re-evaluate and concluded a window of opportunity was at hand.
The artists wholeheartedly believed they could produce a Broadway-inspired benefit concert inside Jack London State Park, and raise enough funds to prevent its closure. The park service agreed. In October 2011, the one-night event of song and dance under the stars attracted hundreds of spectators from Marin, Sonoma, Napa, and beyond.
Virtually an overnight success, TTC secured a contract with the California State Parks, granting them the authorized use of Jack London State Park for future Broadway musical productions; the agreement also stipulated that a portion of all future performance proceeds would go toward the park.
TTC's inaugural season of "Broadway Under the Stars" in the summer of 2012 was a resounding sell-out. Even with the ambitious goal to raise $250K within their first season- TTC met the challenge; a feat few arts organizations could achieve in such limited time.
Last spring I had the privilege of previewing the talent behind TTC, at an informal performance at the Sonoma County Dance Center. All six founding members were present, along with guest artist Rachel Louise Thomas, visiting from Los Angeles. Song and dance from a variety of musicals were performed; among them "42nd Street," "Mary Poppins," and "Dora the Explorer."
In having the opportunity to hear TTC's inspiring story aloud and view a sampling of their talent, I fell captive to their transcending effect. Rarely does one come across such a vivacious group so well equipped with the tools for success. Sustaining TTC's ambitious vision requires a considerable amount of talent, business savvy and organization. Based on what TTC has demonstrated over just a few seasons thus far, nothing short of greatness is in the stars for these high-achievers.
Until next time. Live. Dance. And Prosper.
cabaret styleentertainmentlive entertainmentmusical theatreSonomaState Parktourist attractionTranscendence Theatre Company
Jasmine Rios
Freelance writer Jasmine Rios/aka Mina by trade – found inspiration in dance through film and exposure to live performances at an early age. Trained in music, theatre, and dance; followed by study in Journalism & Mass Communications, Rios now writes for publications which include: Dance International Magazine, Dance For You Magazine, ExploreDance.com, and the North Bay Bohemian newspaper; she is also the founder of Mina Communications – a consulting business for the arts.
Mimi Tompkins – Next Chapter
Mimi Tompkins – Audition Tips
DDS Reviews: So You Think You Can Dance Live!
Staying connected with dance over the winter break
Holiday Traditions


ain't nobody got time for web links when there are fireworks to be watched and parades to be attended and flags to be waved. happy happy birthday america!!! i hope you all have a safe and wonderful holiday!
Next Post CELEBRATING THE FOURTH!


US President Donald Trump is going through a longshot problem from inside his personal occasion forward of subsequent yr's White Home election.
However he faces an uphill battle to take over a Republican occasion that has been refashioned in Mr Trump's picture.
"I actually suppose if we have now six extra years of the identical stuff we have had out of the White Home the final two years that will be a political tragedy," he mentioned on CNN.
Mr Weld's campaign video touts his cross-party credentials as a Republican who was elected within the Democratic stronghold of Massachusetts.
However underscoring the lengthy odds for him, occasion leaders promptly rejected his marketing campaign.
"Any effort to problem the president's nomination is certain to go completely nowhere," the Republican Nationwide Committee mentioned in assertion.
In keeping with the newest Gallup ballot, 89% of Republican voters approve of the president.
Mr Trump's marketing campaign mentioned on Sunday it had raised greater than $30m within the first quarter of this yr, far outpacing the political battle chests of particular person Democratic candidates.
Former Ohio Governor John Kasich and Maryland Governor Larry Hogan have additionally been talked about in latest months as potential occasion challengers to Mr Trump.
Subsequent yr Republican and Democratic voters will maintain elections often known as primaries to select their respective occasion's normal bearer for the November 2020 presidential election.
Sitting presidents don't normally face inner challengers, and just a few have ever been denied renomination by their occasion.
Sports activities betting: are Ugandans hooked on it?


The 'Teaching GCSE' course is aimed at those wishing to teach Computing/Computer Science GCSE. It is a beginner's course, assuming nothing more than some exposure to programming (e.g. using Scratch, Logo or Flowol).
Accompanying course materials can be found on the GCSE Computing CPD Resources page. Login details will be given to those attending the course. Please contact us if you would like to deliver a version of it to your local teachers.
Although the exact content of each course may vary slightly this is a typical programme.
1 Introduction to the coursePython programming: integers, string and expressions. Writing scripts; simple input and output.
2 Computer components and binary numbers.
3 Python programming: conditional statement; Boolean expressions; dry running programs.
4 Python programming: while loops. Program errors.
6 Python programming: arrays, lists and for loops. Program testing.
9 Logic circuits: adding with logic.
This course does not cover the whole curriculum but concentrates on the parts that are most different from existing ICT curricula, particularly programming. Delegates do lots of practical programming, aiming to get to the level of a GCSE controlled assessment (and beyond).
Please to sign-up to our mailing list to be kept informed of future courses.
Hello Jonathan – I don't have any dates for the GCSE courses but when we do they'll be posted on the GCSE page (https://teachinglondoncomputing.org/cpd-courses/for-gcse-computing/) and we'll also send an email round to our subscribers – if you're not on the list and want to be please visit out sign-up page (https://teachinglondoncomputing.org/sign-up/).
Please could you add some summer courses for GCSE Computing and python.
Hi Z – we do hope to have at least one more Computing GCSE running soon – it will likely be an intensive type of course possibly running over one week or stretched over two weeks.


Vaccines and antibiotics occupy a privileged position in the history of medicine. They are humanity's "magic bullets" — categories of intervention so effective and easy to deliver that they have the capacity to single-handedly eradicate entire diseases from human history. But just as the heady utopia of an antibiotic age has given way to the cold, evolutionary reality of antibiotic resistance, we must now also confront the pervasive problem of vaccine failure in the global South.
Vaccines fail for many reasons. Years of effort have failed to deliver a vaccine for HIV. In many cases the best solution may simply be to focus resources on alternative therapies, much as antiretroviral drugs have reduced the burden of HIV in the absence of an effective vaccine.
What is more immediately concerning is the existence of vaccines that are known to be completely effective in industrialized nations, but that show reduced efficacy when introduced to impoverished communities in the global South.
The 20th century witnessed concerted humanitarian efforts to introduce polio vaccines to the poorest corners of the world, with the hope of eradicating the disease entirely. It was during these efforts that someone first observed reduced vaccine efficacy in ultrapoor communities.


text:
Description: sodium channel, voltage-gated, type XI, alpha
Gene: Scn11a Synonyms: nav3.1, nav1.9, scn11a
Edit - History
The gene SCN11A (also known as NaN; SNS-2; NAV1.9; SCN12A) encodes Nav1.9, a voltage-gated sodium channel alpha subunit, type XI. Although Nav1.9 shares only 50% identity with most of the other Nav isoforms, it does not, based on phylogeny, belong to a new Na channel subfamily. Nav1.9 is best known for its high expression levels in peripheral sensory neurons and is thought to carry the NaN current, a persistent and tetrodrotoxin (TTX)-resistant voltage-gated Na Current , possibly involved in pain-related signaling [1438].
The tetrodotoxin resistant NaV1.5, NaV1.8, and NaV1.9 are closely related ( see phylogenetic tree, fig. 2B in Catterall [817]), and their amino acid sequences are greater than 64% identical to those of the four sodium channels encoded on chromosome 2 (the highly tertodotoxin sensitive NaV1.1, NaV1.2, NaV1.3, and NaV1.7). [817]
RGD ID
3630 8 124724493-124794654 Rat
735313 9 119662881-119734574 Mouse
1342640 3 38887260-38992052 Human
Scn11a : sodium channel, voltage-gated, type XI, alpha
Acc No
NM_019265 n/A n/A NCBI
GO:0001518 voltage-gated sodium channel complex A sodium channel in a cell membrane whose opening is governed by the membrane potential. IEA
GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA
GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA
GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IEA
GO:0030424 axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. IEA
GO:0044299 C-fiber The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated. IEA
There are several molecules that increase Nav1.9 currents in DRG neurons:
-Inflammatory mediators (PGE2, serotonin, bradykinin, histamine, PGE3 and norepinephrine [223],[1440].
-Secreted proteins that augment neuronal survival (BDNF, GDNF)[1438][1442].
Mibefradil, a non-dihydropyridine ICaT antagonist, blocks Nav1.9. Amiloride, however, a preferential Cav3.2 channel blocker, had no effects on Nav1.9 current. [224].
NaV1.9 (as well as NaV1.5 and NaV1.8) is tetrodotoxin-resistant due to changes in amino acid sequence at a single position in domain I. In contrast to NaV1.1, NaV1.2, NaV1.3, and NaV1.7 which are are all four highly tetrodotoxin-sensitive. [817]
Tetrodotoxin
Nav1.9 is TTX resistant (selective) [1376]
Nav1.9 it is formed of 1765 residues and contains all the hallmarks of Na+ channels, including the inactivation tripeptide Ile-Phe-Met in L3. Nav1.9 also contains multiple predicted phosphorylation sites in the intracellular loops and N-glycosylation sites in the extracellular linkers [1439]. The alpha subunits - such as Nav1.9 - are organized in four homologous domains (I-IV), each of which contain six transmembrane alpha helices (S1-S6) and an additional pore loop located between the S5 and S6 segments (Fig. 1 in Catterall [817]). The pore loops line the outer, narrow entry to the pore, whereas the S5 and S6 segments line the inner, wider exit from the pore. The S4 segments in each domain contain positively charged amino acid residues at every third position. These residues serve as gating charges and move across the membrane to initiate channel activation in response to depolarization of the membrane. The short intracellular loop connecting homologous domains III and IV serves as the inactivation gate, folding into the channel structure and blocking the pore from the inside during sustained depolarization of the membrane. [817]. These alpha subunits, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex.
Nav1.9 immunoreactivity is present within the somata of small DRG neurons, along their peripheral projections to the nerve endings in the skin and cornea, and along their central projections (in the dorsal root) to terminals in substantia gelatinosa of the spinal cord: mainly in small diameter C fibres and medium-sized A-delta and a few large diameter A-beta fibres. (For further information see [1438], [1441],[871]). Its presence at nerve endings is consistent with its role of amplifying subthresold stimuli [870].
Surface localization of Nav1.9 appears to be related to its association with the cell adhesión molecule contactin/F3 [1439].
(For further information see [1438], [871]) Nav1.9 is found primarily within small sensory neurons (<30 μm diameter) of dorsal root ganglia (DRG) and trigeminal ganglia, but not in neurons and glia within the CNS, or in muscle. Low levels of transcripts were detected in retina but not in cerebellum and spinal cord or in satellite and Schwann cells within DRG.
Nav1.9 is relatively resistant to TTX, but has kinetic properties distinct from the similarly TTX-resistant Nav1.8, producing a persistent current with an activation potential of −70mV, close to the resting membrane potential, where it may set the threshold for activation [1441].
Modulation of the resting-closed states of NaV1.9 channels strongly influences nociceptor excitability and may provide a mecha ¡nism by which inflammatory mediators alter pain threshold [222].
Inflammatory mediators increase the Nav1.9 sodium current acting via a G-protein-dependent mechanism which up-regulate the persistent Nav1.9 current producing changes in membrane excitability sufficient to cause spontaneous activity, even at a membrane potential near –60 mV [1448].
As with Nav1.8, expression and/or function of Nav1.9 in sensory pathways is drastically reduced in various models of neuropathic pain (review [1438]):
• In DRG after neuropathic injury [1443]
• In a trigeminal ganglia model of neuropathic pain [1444]
Several models and human cases of radicular pain [1445]
Mouse models: Nav1.9 null [1446]
Detailed electrophysiological measurements on isolated sensory neurons suggest that Nav1.9 has a novel gating mechanism in small diameter DRG neurons [224] that may drive spontaneous discharge during. In addition, it was demonstrated that inflammatory mediators can dynamically regulate putative Nav1.9 currents in wild-type DRG neurons isolated from mice [1440], [1438].
Activation:
Threshold -70 to -60 mV (rat DRG), -80mV (human) V-a = -47 to -54 mV (rat DRG) [868], [869], [870]; 2.93 ms at -60 mV, 4.1 ms at -50 mV, 3.5 ms at 20mV, and 2.5 ms at -10 mV. [870]
Inactivation:
V-h = -44 to -54 mV1,3; tau-h 843 ms at -60 mV, 460 ms at -50 mV, 43 ms at -20mV, and 16 ms at -10 mV [870]
Catterall WA. et al. International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.
Pharmacol. Rev., 2005 Dec , 57 (397-409).
Fozzard HA. et al. Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms.
Physiol. Rev., 1996 Jul , 76 (887-926).
Catterall WA. et al. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels.
Neuron, 2000 Apr , 26 (13-25).
Cummins TR. et al. A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons.
J. Neurosci., 1999 Dec 15 , 19 (RC43).
Cummins TR. et al. Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy.
J. Neurosci., 2000 Oct 1 , 20 (7279-89).
Black JA. et al. The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons.
J. Neurosci., 2002 Sep 1 , 22 (7425-33).
Black JA. et al. NaN/Nav1.9: a sodium channel with unique properties.
Trends Neurosci., 2002 May , 25 (253-9).
Coste B. et al. Pharmacological dissection and distribution of NaN/Nav1.9, T-type Ca2+ currents, and mechanically activated cation currents in different populations of DRG neurons.
J. Gen. Physiol., 2007 Jan , 129 (57-77).
Coste B. et al. Gating and modulation of presumptive NaV1.9 channels in enteric and spinal sensory neurons.
Mol. Cell. Neurosci., 2004 May , 26 (123-34).
Rush AM. et al. PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins.
Brain Res., 2004 Oct 15 , 1023 (264-71).
Coste B. et al. Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism.
J. Gen. Physiol., 2008 Mar , 131 (211-25).
Coste B. et al. Na+ channel Nav1.9: in search of a gating mechanism.
Trends Neurosci., 2003 Feb , 26 (55-7).
Cummins TR. et al. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons.
Brain Res. Mol. Brain Res., 1999 Apr 20 , 67 (267-82).
Baker MD. et al. Low-threshold, persistent sodium current in rat large dorsal root ganglion neurons in culture.
J. Neurophysiol., 1997 Mar , 77 (1503-13).
Xu J. et al. Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases.
Neuroscience, 2002 , 114 (529-46).
Fried K. et al. Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model.
Pain, 2005 Dec 15 , 119 (82-94).
Tanabe T. et al. Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain.
Spine, 2002 Jul 15 , 27 (1517-24; discussion 1525).
Wood JN. et al. GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9.
J. Physiol. (Lond.), 2008 Feb 15 , 586 (1077-87).
Waxman SG. et al. Nav1.9, G-proteins, and nociceptors.
J. Physiol. (Lond.), 2008 Feb 15 , 586 (917-8).
Cummins TR. et al. Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons.
J. Neurophysiol., 2001 Sep , 86 (1351-64).


Find the right size Goodyear Eagle Touring Tire for your vehicle.
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text:
Nanogenerator Intros New Energy Unit - The Pinch
The first commercially viable nanogenerator, a flexible chip that can produce energy from body movements, has been created, according to lead scientist Zhong Lin Wang, Ph.D.
(Nanogenerator)
"This development represents a milestone toward producing portable electronics that can be powered by body movements without the use of batteries or electrical outlets," said lead scientist Zhong Lin Wang, Ph.D. "Our nanogenerators are poised to change lives in the future. Their potential is only limited by one's imagination."
The latest improvements have resulted in a nanogenerator powerful enough to drive commercial liquid-crystal displays, light-emitting diodes and laser diodes. By storing the generated charges using a capacitor, the output power is capable to periodically drive a sensor and transmit the signal wirelessly.
"If we can sustain the rate of improvement, the nanogenerator may find a broad range of other applications that require more power," he added. Wang cited, for example, personal electronic devices powered by footsteps activating nanogenerators inside the sole of a shoe; implanted insulin pumps powered by a heart beat; and environmental sensors powered by nanogenerators flapping in the breeze.
The key to the technology is zinc oxide (ZnO) nanowires. ZnO nanowires are piezoelectric — they can generate an electric current when strained or flexed. That movement can be virtually any body movement, such as walking, a heartbeat, or blood flowing through the body. The nanowires can also generate electricity in response to wind, rolling tires, or many other kinds of movement.
The diameter of a ZnO nanowire is so small that 500 of the wires can fit inside the width of a single human hair. Wang's group found a way to capture and combine the electrical charges from millions of the nanoscale zinc oxide wires. They also developed an efficient way to deposit the nanowires onto flexible polymer chips, each about a quarter the size of a postage stamp. Five nanogenerators stacked together produce about 1 micro Ampere output current at 3 volts — about the same voltage generated by two regular AA batteries (about 1.5 volts each).
This is just what you want in your stillsuit, the key piece of Fremen equipment that allows human beings to survive on Dune. According to Frank Herbert, a stillsuit is powered by "motions of the body".
Via Eurekalert.
Related News Stories - (" Engineering ")
'The dragon is a skin computer... People put it on their arms and exchange personal data.' Greg Bear, 2009.
Let the Wookiee win. - George Lucas, 1976.
The Details Of Tesla's FSD Full Self-Driving
'As the beautiful old car cruised in almost perfect silence under the guidance of it's automatic controls...' - Arthur C. Clarke, 1976.
Augmented Reality Palm Keyboard
'Three rows of four colored dots appeared on the heel of my left hand.'- John Varley, 1992.


text:
<?php

namespace Faker\Provider;

class Internet extends \Faker\Provider\Base
{
    protected static $freeEmailDomain = array('gmail.com', 'yahoo.com', 'hotmail.com');
    protected static $tld = array('com', 'com', 'com', 'com', 'com', 'com', 'biz', 'info', 'net', 'org');

    protected static $userNameFormats = array(
        '{{lastName}}.{{firstName}}',
        '{{firstName}}.{{lastName}}',
        '{{firstName}}##',
        '?{{lastName}}',
    );
    protected static $emailFormats = array(
        '{{userName}}@{{domainName}}',
        '{{userName}}@{{freeEmailDomain}}',
    );
    protected static $urlFormats = array(
        'http://www.{{domainName}}/',
        'http://{{domainName}}/',
    );

    /**
     * @example 'jdoe@acme.biz'
     */
    public function email()
    {
        $format = static::randomElement(static::$emailFormats);

        return preg_replace('/\s/u', '', $this->generator->parse($format));
    }

    /**
     * @example 'jdoe@example.com'
     */
    final public function safeEmail()
    {
        return preg_replace('/\s/u', '', $this->userName() . '@' . static::safeEmailDomain());
    }

    /**
     * @example 'jdoe@gmail.com'
     */
    public function freeEmail()
    {
        return preg_replace('/\s/u', '', $this->userName() . '@' . static::freeEmailDomain());
    }

    /**
     * @example 'jdoe@dawson.com'
     */
    public function companyEmail()
    {
        return preg_replace('/\s/u', '', $this->userName() . '@' . $this->domainName());
    }

    /**
     * @example 'gmail.com'
     */
    public static function freeEmailDomain()
    {
        return static::randomElement(static::$freeEmailDomain);
    }

    /**
     * @example 'example.org'
     */
    final public static function safeEmailDomain()
    {
        $domains = array(
            'example.com',
            'example.org',
            'example.net'
        );

        return static::randomElement($domains);
    }
    /**
     * @example 'jdoe'
     */
    public function userName()
    {
        $format = static::randomElement(static::$userNameFormats);

        return static::toLower(static::bothify($this->generator->parse($format)));
    }

    /**
     * @example 'tiramisu.com'
     */
    public function domainName()
    {
        return $this->domainWord() . '.' . $this->tld();
    }

    /**
     * @example 'faber'
     */
    public function domainWord()
    {
        $company = $this->generator->format('company');
        $companyElements = explode(' ', $company);
        $company = $companyElements[0];
        $company = preg_replace('/\W/u', '', $company);

        return static::toLower($company);
    }

    /**
     * @example 'com'
     */
    public function tld()
    {
        return static::randomElement(static::$tld);
    }

    /**
     * @example 'http://www.runolfsdottir.com/'
     */
    public function url()
    {
        $format = static::randomElement(static::$urlFormats);

        return $this->generator->parse($format);
    }

    /**
     * @example '237.149.115.38'
     */
    public function ipv4()
    {
        return long2ip(mt_rand(0, 1) == 0 ? mt_rand(-2147483648, 0) : mt_rand(1, 2147483647));
    }

    /**
     * @example '35cd:186d:3e23:2986:ef9f:5b41:42a4:e6f1'
     */
    public function ipv6()
    {
        $res = array();
        for ($i=0; $i < 8; $i++) {
            $res []= dechex(mt_rand(0, "65535"));
        }

        return join(':', $res);
    }
}

redpajama_set_name: RedPajamaGithub


For her consistent and fearless fight over the years for her people's independence and dignity. Her work for human rights and co-existence with the state of Israel has won respect in all camps. She is a leading force in the struggle for increased openness and democratic structures within her own Palestinian ranks. Hanan Ahrawi is an inspiring symbol of a new, democratic, peaceful Middle East.


text:
OLLI plays, IlluminAid showcase actor,…
OLLI plays, IlluminAid showcase actor, humanitarian aid
By Jennie Blevins | jblevins@chicoer.com |
April 23, 2022 at 3:10 a.m.
CHICO — The Osher Lifelong Learning Institute program will be holding two virtual events at the end of April.
The OLLI play festival series, which was developed by OLLI member and artistic director Pam Loyd, is a series of one-act comedies written, directed and staged by OLLI members. Loyd teaches a playwriting class and the play's authors took her class. This year, eight of the participants include OLLI members from New York, Rhode Island, Minnesota and Florida. The event will take place online and is free.
The festival is transitioning from a physical stage to a virtual stage. The online format has provided new opportunities to expand OLLI Chico's theater troupe to include people from across the country. The plays will be released in a pre-recorded video April 30.
The plays are each 10 to 20 minutes long. In the past, the plays were performed at the Blue Room prior to the COVID-19 pandemic, but when the pandemic hit, the plays were switched to Zoom, with all rehearsals and the performances taking place virtually. One of the advantages to having virtual plays is that OLLI members from other states can participate. The actors auditioned and rehearsed on Zoom for six weeks.
Loyd is directing two of the plays. When she gave instructions to the playwriting class, she told them the plays must be written in such a way that the characters can't be in the same room or physically touch due to the virtual platform.
Loyd's favorite play is called "Sunrise Speaks," which is about a Zoom advice columnist. Loyd is happy about the fact that women of a certain age are acting, writing and staging the plays. She wanted to showcase actors over 50 and have the plays not be centered on old age or set in a nursing home.
"The plays are lively, energetic, sexy and romantic," she said. "It's a positive image for people over 50."
Roger Gans, who is from south of Rochester, New York and is acting in one of the plays, "Mirror, Mirror," found the play to be a positive experience. He also does video editing.
Gans has been acting for years. He got involved with the OLLI Chico plays when the OLLI director distributed information about the plays across the country.
There are three other actors in the play.
"It was different being on Zoom while acting," Gans said.
Gans teaches an OLLI class on flight. He has also taught a course on Darwin and evolution. He has acted in plays written by playwright and actor Wallace Shawn, including "The Designated Mourner."
"I love the idea of operating on a cross-country basis," Gans said. "It makes up for the disadvantages of being on Zoom."
IlluminAid
The second event is an IlluminAid workshop which takes place April 28 from 3 to 4 p.m. on Zoom. IlluminAid Executive Director Matt York will share the purpose and focus of his most recent trips to Togo in West Africa on behalf of the organization. IluminAid's mission is to help in educating the world's poorest people through low-cost video technology.
To watch the three-minute video, visit the IlluminAid website at https://www.illuminaid.org/ at the end of April.
"We're highlighting the most recent work we did in the world's 70 poorest countries," York said.
So far IlluminAid has completed 35 of these workshops.
"The service we provide is in regards to training people to adopt a different lifestyle," York said. "We are planting more rice plants per square foot. We teach people to wear a mask if required, to wash their hands after using the bathroom, to use a latrine instead of defecating in public and to use birth control. We want to foster new behaviors in the population. Videos will be shared on cordless video projectors."
For more information about OLLI, visit https://rce.csuchico.edu/osher. Links are available on olli.csuchico.edu.
This is a live online event open to all. The Zoom link to enter the event will be posted on the home page of the OLLI website starting in the morning on the day of the event, Thursday, April 28.
The links for the four plays will be accessible through the home page of the OLLI website. The plays have been pre-recorded and will be released April 30. OLLI members, friends and the general public should go to olli.csuchico.edu for information on that day. The links to the recordings are accessible. Participants can click on a link and watch the recording.
Jennie Blevins
Pooch Playoffs aim to help all furry creatures
Butte College hosts series of events for Black History Month
'Sleeping Beauty' spins its magic at Laxson Auditorium
Horoscopes Feb. 2, 2023: Shakira, make your energy work for you


text:
Smaller Projects
Foulger & Foulger Limited
Content strategy and development, project direction and writing
Visitors to the Science of Aliens exhibition.
Considering the audience is the point of departure for Stephen on any project. Who are they? What are their experiences, motivations and expectations? What do we want to say to them?
Stephen structures development processes involving stakeholder and multiple creative inputs to develop messaging and media that communicate coherently and produce outstanding and memorable visitor experiences. There are a number of tools that can help in this process:
Messaging hierarchies
Learning outcomes (see the UK Museum and Libraries Association generic learning outcomes)
Audience segmentation
Multiple intelligences (see the work of Howard Gardner)
Psychological motivations and rewards for engagement
Audience and user personas
User testing and audience evaluation
Stephen deploys some or all of these as necessary and would be delighted to discuss which techniques can be most usefully and practically applied on a given project.
Stephen has led teams as well as joined projects slotting into existing team structures. He can also work as an external consultant, depending on the needs of the project. Over the last twenty years, Stephen has built up a network of talented individuals, agencies and companies that he can draw on to deliver projects of any size.
©2020 Foulger & Foulger Limited	| Powered by WordPress & Superbthemes


text:
Q: ListView with custom Cell click handling In my JavaFX app I use ListView with custom cells. I want to handle list item clicks differently than clicks on the empty space below the items. I've set an event listener on whole ListView, but I can't determine which of the items was clicked (getSelectedItem() is null, probably because of bug in my custom cell code). How to handle following situation properly?
My component looks like this:

<fx:root type="javafx.scene.layout.VBox">
    <Label fx:id="dayname" text="${controller.day.name}" />
    <ListView fx:id="appointmentsListView" items="${controller.day.events}"
        onMouseClicked="#handleAppointmentsClick" />
</fx:root>

ListView has custom cell factory which is set in component constructor:

public class DayComponent extends VBox {
    @FXML
    private ListView<Appointment> appointmentsListView;

    public DayComponent() throws IOException {
        // ...
        appointmentsListView.setCellFactory(l -> new AppointmentCell());
    }

    @FXML
    public void handleAppointmentsClick(MouseEvent event) {
        System.out.println(appointmentsListView.getSelectionModel()
            .getSelectedItem()); // null in every case
    }
}

Custom cell code:
public class AppointmentCell extends ListCell<Appointment> {

    @Override
    protected void updateItem(Appointment item, boolean empty) {
        super.updateItem(item, empty);
        if (!empty) {
            setGraphic(new AppointmentLabel(item));
        } else {
            setGraphic(null);
        }
    }
}

A: One reasonably clean approach is to register a mouse listener with the cells in the list view, to handle clicks on non-empty cells. Consume the mouse event if the cell is non-empty. Register a second mouse listener on the list view itself, to handle clicks on empty cells (or on the list view's placeholder if the list view is empty). This needs two handlers, but at least separates the "empty" and "non-empty" functionality in a sensible way.
Here is a quick example:
import javafx.application.Application;
import javafx.scene.Scene;
import javafx.scene.control.Button;
import javafx.scene.control.ButtonBar;
import javafx.scene.control.ListCell;
import javafx.scene.control.ListView;
import javafx.scene.layout.BorderPane;
import javafx.stage.Stage;

public class ListViewMouseHandlerExample extends Application {

    private int count = 0 ;

    @Override
    public void start(Stage primaryStage) {
        ListView<String> listView = new ListView<>();

        Button addButton = new Button("Add");
        addButton.setOnAction(e -> listView.getItems().add("Item " + (++count)));

        Button deleteButton = new Button("Delete");
        deleteButton.setOnAction(e -> listView.getItems().remove(listView.getSelectionModel().getSelectedIndex()));
        deleteButton.disableProperty().bind(listView.getSelectionModel().selectedItemProperty().isNull());

        listView.setCellFactory(lv -> {
            ListCell<String> cell = new ListCell<String>() {
                @Override
                protected void updateItem(String item, boolean empty) {
                    super.updateItem(item, empty);
                    setText(item);
                }
            };
            cell.setOnMouseClicked(e -> {
                if (!cell.isEmpty()) {
                    System.out.println("You clicked on " + cell.getItem());
                    e.consume();
                }
            });
            return cell;
        });

        listView.setOnMouseClicked(e -> {
            System.out.println("You clicked on an empty cell");
        });

        BorderPane root = new BorderPane(listView);
        ButtonBar buttons = new ButtonBar();
        buttons.getButtons().addAll(addButton, deleteButton);
        root.setBottom(buttons);

        Scene scene = new Scene(root, 600, 600);
        primaryStage.setScene(scene);
        primaryStage.show();
    }

    public static void main(String[] args) {
        launch(args);
    }
}

A: You could try something like that:
public class AppointmentCellMouseClickHandler implements EventHandler<MouseEvent> {

    private final Appointment appointment;

    public AppointmentCellMouseClickHandler(Appointment appointment) {
        this.appointment = appointment;
    }

    @Override
    public void handle(MouseEvent arg0) {
        //Do stuff with appointment
    }
}

public class EmptyAppointmentCellMouseClickHandler implements EventHandler<MouseEvent> {

    @Override
    public void handle(MouseEvent arg0) {
        //Do stuff without appointment
    }
}

public class AppointmentCell extends ListCell<Appointment> {

    @Override
    protected void updateItem(Appointment item, boolean empty) {
        super.updateItem(item, empty);
        if (!empty) {
            setGraphic(new AppointmentLabel(item));
            this.setOnMouseClicked(new AppointmentCellMouseClickHandler(item));
        } else {
            setGraphic(null);
            this.setOnMouseClicked(new EmptyAppointmentCellMouseClickHandler());
        }
    }
}

Edit related to comment:
To handle when the ListView is empty you can do:
//To handle the initialisation where the listener won't be call
appointmentsListView.setOnMouseClicked(new EmptyAppointmentCellMouseClickHandler());
appointmentsListView.getItems().addListener(new ListChangeListener<Appointment>() {
            @Override
            public void onChanged(Change<? extends Appointment> change) {
                while(change.next()){
                    //Toogle the listener depending on the content of the list
                    listView.setOnMouseClicked(change.getList().isEmpty() ? new EmptyAppointmentCellMouseClickHandler() : null);
                }
            }
        });

redpajama_set_name: RedPajamaStackExchange


text:
→ Small Plane Crash in Minnesota – Multiple Fatalities
Small Plane Crash in Minnesota – Multiple Fatalities
by Eric Rhine | Aug 8, 2021 | Aviation Accident, Wrongful Death
There was a fatal plane crash in Victoria, Minnesota on August 7, 2021. The plane, a single engine Mooney M20, crashed into a home on Saturday night. One eyewitness indicates he heard a loud pop and one of the plane's wings appeared to have snapped off. The plane then spiraled out of control to the ground below. The plane was en route from Alexandria Municipal Airport to Flying Cloud Airport. Multiple fatalities have been reported. Our thoughts and prayers go out to those impacted by this deadly accident.
There have been a number of recent plane crashes in 2021. Six people were killed when a sightseeing plane crashed in Alaska on August 5, 2021. A Cessna 206 plane crashed in Katmai National Park and Preserve, Alaska on July 31, 2021. There was a small plane crash in Hartford, Wisconsin on July 31, 2021. There was a small plane crash in Lexington, Kentucky on July 28, 2021. A Cessna 150 crashed in Whiteside County, Illinois on July 23, 2021. There was a small plane crash in Harrah, Oklahoma on July 23, 2021. A Beechcraft Bonanza plane crashed in Napa County, California on July 16, 2021. On July 14, 2021, a Piper PA-28-180 crashed in Iowa, killing two.


Tottenham Hotspur are considering a move in signing Lille's Sofiane Boufal. The attacking midfielder joined the Ligue 1 outfit from French side Angers in January.
The 21-year-old signed a four-and-a-half-year deal with Lille earlier this year and has already impressed with his dribbling skills and style of play. According to Italian publication Tuuto Mercato Web, the north London club are interested in securing his services.
The French-born Moroccan international has been monitored by Mauricio Pochettino and has sent his scouts to watch the midfielder in action. The Argentine manager is weighing in a move for Boufal.
The attacking midfielder's agent and director at agency Sport Profile Yvan Le Mee admitted his client needs to grow at Lille. He stressed the failure in his developments will force Boufal to look elsewhere and also admitted earlier in July a move to a top club for the Moroccan is not on the cards.
"The club and the player must grow up together, otherwise a time will come when we have to make decisions," Le Mee told Get French Football News. "He has the potential and is still young enough to be able play in the most prestigious leagues but he must get used to Ligue 1 first, impress in terms of statistics, improve tactically and become physically fitter first."
"He would confirm his abilities, if he scores 10 goals and 10 assists next season, but if he doesn't, no one will see it as failure as he is only 22. At the moment a transfer to a bigger club is not at the top of the agenda," Boufal's representative added.
With Le Mee's latest comments, the White Hart Lane club could wait for one more season before making an approach for Boufal. He is hoping to emulate Brazil legend Ronaldinho's skills on the pitch.
"I like to try things, to take players on and dribble with the ball. I played a lot of football when I was little and that helped me to work on my technique, to do nutmegs and flicks," Boufal told Ligue 1's official website in April.
"I really like Ronaldinho... and Zidane. But more Ronaldinho... I loved the way he'd put on a show... I loved his dribbling, his pure skill."


Periodontal disease is the most common dental condition in dogs and cats, an in fact, one of the most common diseases treated by veterinarians, period. Most pets will show signs of periodontal disease by 3 years of age. If untreated, periodontal disease can progress to a much more painful condition, and can ultimately result in problems with the liver, kidneys, and heart.
Periodontal disease starts with plaque. If plaque is left on the teeth it hardens into tartar. Tartar can be seen not only above the gumline, but below it as well. It is this "invisible" tartar that can result in infection and severe damage to the root and surrounding bone, ultimately requiring extraction of any affecting teeth.
Early periodontal disease can be treated by a thorough dental cleaning (under anesthesia, click here for more information as to why). Dental x-rays can also help to determine the extent of periodontal disease and whether or not extraction of affected teeth may be needed.
Periodontal disease is preventable! Daily brushing is the single most important thing in keeping your pet's mouth healthy. Just like us, your pet will still require regular cleanings by your veterinarian, but daily brushing can significantly reduce the frequency of such procedures.
I think it's important to check the teeth even in a dog that is under a year old. We have a one year old that already has to have dental scraping done. Obviously we are going to do this. But originally I had thought that dental issues were with older dogs only.
Thank you for this page, btw. Sharing with a couple of friends who also need to read this.


text:
Digitale Auskunft (auch: Virtuelle Auskunft) ist ein Sammelbegriff im Bibliothekswesen für sämtliche Auskunfts- und Informationsaktivitäten, die über elektronische Kanäle, meist über das Internet, abgewickelt werden.

Je nach dem für den digitalen Auskunftsdienst eingesetzten Internet-Protokoll entsteht eine Chat- oder E-Mail-Auskunft mit synchroner oder asynchroner Kommunikation.

Technische Basis für digitale Auskunftsdienste bilden spezielle Software-Pakete, die meistens von Bibliotheken oder Bibliotheksdienstleistern nach individuellen Bedürfnissen entwickelt werden. Inzwischen werden die Quellcodes einiger Eigenentwicklungen zur kostenfreien Nachnutzung angeboten. Die Programme unterstützen Chat- oder E-Mail-basierte Auskunftsdienste; manche sind modular aufgebaut und können für beide Varianten eingesetzt werden.

Um punktuell vorhandenes Spezialwissen und die insgesamt zur Verfügung stehenden Personalressourcen effizient nutzen und damit die Auskunftsuchenden optimal bedienen zu können, schließen sich immer mehr Bibliotheken zu kooperativen digitalen Auskunftsdiensten zusammen. Vorreiter dieses Modells in Deutschland war die Deutsche Internetbibliothek, die neben einer strukturierten Linksammlung eine E-Mail-Auskunft anbietet. In der DIB hatten sich in einem von der Bertelsmann-Stiftung geförderten Projekt 70 öffentliche Bibliotheken zusammengeschlossen, inzwischen ist der Teilnehmerkreis weiter angewachsen. Im Herbst 2004 startete mit InfoPoint die erste Auskunftskooperative in Deutschland, in der Bibliotheken verschiedener Typen, Größe und Ausrichtung zusammenarbeiten und ebenfalls einen E-Mail-basierten Dienst anbieten.

Digitale Auskunftsdienste
 Von Bibliotheken: InfoPoint, QuestionPoint, DigiAuskunft, Deutsche Internetbibliothek, Al@din
 Von einer Freiwilligen-Gemeinschaft: Naver, Yahoo! Clever, COSMiQ, Wer-weiss-was.de, gutefrage.net, Quora, Stack Exchange
 Von bezahlten Experten: Google Answers (inzwischen eingestellt)

Siehe auch
 Auskunftsbibliothekar
 Internetforum und Mailingliste dienen häufig auch zur digitalen Auskunft

Literatur
 IFLA Richtlinien Digitale Auskunft (PDF-Datei; 104 kB)

 Digitale Auskunft
Dienstleistung in Bibliotheken


Pet friendly dog beaches in Florida abound, including the famous Browhard Paw Park Dog Beach in Venice Florida. If you are staying in one of our Florida Pet Friendly Vacation Rentals, there's sure to be a pet and dog friendly beach just a short drive away.
As seen in popular films like 'Marley and Me', Florida's dog beaches are gorgeous places for your beloved pet to play, chase and swim.
Your resort or vacation rental may have walking trails and many of Florida's towns and cities are famous for being pet-friendly, yet, the time together at the dog beach will make your vacation.
The scenery and regulations at dog beaches vary and, below, we've listed our favorite dog-friendly beaches in Florida.
Ensure a happy vacation for you and your dog.
Try to call ahead and confirm that the dog beach is open. We do our best to keep this list current but municipal regulations can change suddenly.
Bring plenty of water for your dog! Drinking salt water will make them sick.
Chat to fellow dog owners! Dog owners are known to be the friendliest people and you'll enjoy the added bonus of meeting locals, getting their insight and picking up some great tips on things to do.
Six glorious miles of playtime for your most beloved pet. Flagler Beach is one of Florida's best pet friendly beaches. Running along Highway A1A, it's very easy to get to, yet traffic is no disturbance. In fact, it's known as "Peaceful Beach".
Very steep fines are in place if you don't clean up after your dog ($500) - so bring a bag!
Enjoy a lovely inlet around 1.5 miles of boardwalk. Walk amongst gorgeous sand dunes in this decidedly low-key beach playground. The park is a perfect pet friendly destination, yet the boardwalk can get very hot in the heat of the day and could potentially cause paws to blister. For fantastic walks at cooler hours, whether in the morning or evening, masses of vegetation mean lots of lovely scents for your dog to investigate.
Small sharks inhabit the inlet so please note the leash laws are for your pet's own protection.
Bring your dog along to this pet friendly beach and surrounding trails. While only humans are allowed in the visitor center, historic fort and on boats, the large park, beach and trails provide plenty of space to walk and play.
Lovely St. Johns County is building its pet friendly image and the Paws Dog Park is a crown achievement. The pet playground has a fenced area for dogs as well as an unleashing area to keep both pets and visitors safe. Practice good 'dog diplomacy' and clean up after your pet - the park kindly provides bags, shovels and trash cans for your convenience.
Enjoy three fantastic acres of fenced dog park at St Johns County's Veterans Park. Small dogs can play here separately from big dogs - so their fun never gets out of hand. Bags and trash cans are provided at the park, as are water fountains. While park rules designate that no food or drink enter the dog park, an on-site picnic shelter awaits once your dog is good and tired.
Venice, Florida's Browhard Paw Park is truly Disney World for dogs. Browhard Paw Park features not only a pet friendly beach but a dog park as well, where dogs can run freely and safely within a fenced area. The beach access is off-leash, as well, provided they remain within 100 feet of their owners (so as to maintain voice command) and aren't allowed to dig near sea turtle nests.
Be sure to make Browhard Paw Park a daily destination while visiting Venice!
Both dogs and cats are welcome to visit Sarasota's only pet friendly beach at Bird Key Park.
This Sarasota dog park offers tons of interesting sights, sounds and smells to both regular visitors and dogs on vacation. Divided into areas for small dogs and big dogs, all sizes will enjoy the large box of donated toys, a 'doggie shower' for hot days and acres of grass. A wood chip pile is great for digging in - better there than at your pet friendly vacation rental! The dog park's fire hydrant is a great finishing touch - making this a very memorable destination while on your pet friendly Florida vacation.
Visit this Sarasota dog park and enjoy exercise and games together as a whole family. In addition to a large, fenced dog park, there are jogging trails and a picnic area. Making this a quintessential Florida dog park, your dogs will love playing underneath old oaks with gorgeous Spanish moss. And because it's hot - this pet friendly park has a dog shower too!
Yet another reason to stay in a pet friendly vacation in Venice, Florida! In addition to the fantastic Browhard Paw Park, Venice's Woodmere Paw Park offers a relaxing, natural retreat with plenty of gorgeous vegetation to enjoy. Dogs unused to Florida's lovely sunshine can cool off under the dog park's many shady trees. Family members can enjoy other park facilities while your dog safely plays in the large dog playground.
As its name implies, this is a pet-friendly waterfront walk where leashed dogs are most welcome. Dog bags are provided, as are numerous park benches from which to enjoy the view part-way through your walk. Plenty of shade is available to beat the heat.
Pick and choose from lovely scenery within this dog friendly park; there's an ocean, a quiet inlet and a river to enjoy. Said to be busy during peak weekends, it's an ideal place for a morning walk. Fantastic bird-watching and lovely sand dunes!
No matter which you choose, we hope you enjoy many happy hours at Florida's pet friendly beaches.


The Best Pizzas is a Pizza takeaway in Mexborough. Why don't you try our Beef Burger or Mixed Burger?
BBQ Chicken & Sweetcorn Pizza - 10"
BBQ Chicken & Sweetcorn Pizza - 12"
Garlic Bread with Tomato Sauce - 10"
Garlic Bread with Tomato Sauce - 12"
Garlic Bread, Cheese & Tomato - 10"
Garlic Bread, Cheese & Tomato - 12"
Garlic Bread, Cheese & Bolognese - 10"
Garlic Bread, Cheese & Bolognese - 12"


Mentor Worldwide is a global manufacturer of surgical aesthetic products, including saline silicone, and ultra cohesive breast implants. LEAD stands for Leadership, Experience and Development in Breast Augmentation.
The Mentor LEAD Program Advisory Board invites a select group of plastic surgeons to discuss new products, programs, and innovations. These renowned plastic surgeons come together to exchange experiences and advancements in breast development technology and pioneering progress in this distinctive field.
Dr. Greg Ratliff, Plastic Surgery Center of Tulsa, is proud to be a part of this elite group of breast surgeons. Dr. Ratliff has been a part of this prestigious group since 2010.
Don R. Revis, Jr., M.D.


To read data from a floppy disk to a virtual machine, you must create a disk image that the virtual machine can recognize.
Some operating systems require you to use floppy disks to install them. Because the Mac does not include a physical floppy drive, and because VMware Fusion supports floppy images only, you must use a USB floppy drive to create floppy images.
The Apple Disk Utility can create floppy disk images for this purpose.
Attach a USB floppy drive to your Mac.
Start the Mac Disk Utility by going to Applications/Utilities/Disk Utility on your Mac.
Insert the floppy disk for which you need an image.
In the Disk Utility window, select the floppy disk and click New Image.
In the Image Format pop-up menu, select read/write.
In the Encryption pop-up menu, select None.
Save the floppy disk image to the chosen location.
In the Finder, right-click on the created floppy image and select Get Info.
In Name & Extension, change the file extension from .dmg to .flp and close the Get Info window.
Confirm the change when prompted.
(Optional) Repeat the process for each floppy disk to create.
To attach the images to a virtual machine, see Connect and Set Up a Floppy Device.