Sony Xperia Z3 is the latest flagship smartphone from Sony that boasts the highest waterproof rating, 2-day battery life, PS4 Remote play, Triluminos Display, 20.7 Mega Pixel Camera with 4K recording, larger sensor and highest ISO, making it the most desirable smartphone at the moment. Xperia Z3 is the smartphone that does more and goes further – whether further is a run in the rain or a dive into the pool on a sunny summer holiday. This smartphone is Waterproof and dust resistant, which means that neither water nor dust will get in the way of performance for this slim and sleek smartphone. Find your way in a downpour, take pictures underwater or just wipe off your phone after an unexpected spill. Combined with a super-slim body and aluminium frame, Sony Xperia Z3 is the Android smartphone that teams durability with beauty.
Screen Size : 5.2 inches, Processor Speed : 2.5 GHz, Processor Cores : Quad Core, RAM : 3 GB, Internal Memory : 16GB, Main Camera : Above 20.7 MP, Selfie Camera : 2 MP, Warranty Period : 12 Months Brand Warranty.
This mobile phone comes with a waterproof design blends well with Sony's passion for perfection. It has a super-slim aluminum frame with a uniquely-designed power button and tempered glass panels that gives the whole phone an elite feel to it. Its symmetrical design fits comfortably in your hands, making a convenient phone to carry.
The Sony Xperia Z3 has an IP65/68 rating, which means it is both water and dust resistant. You can take pictures while swimming in fresh water for up to 30 minutes and up to 1.5 meters in depth. Just remember that all the ports are to firmly closed for this feature to work.
Sony Xperia Z3 comes with a large 20.7 Mega Pixel Camera with auto focus. It comes with a massive 1/2.3-inch Exmor RS mobile image sensor that ensures smooth and clear images that extremely realistic. With a 25mm wide-angle lens, you can fit more into the frame on the Xperia Z3. It also comes with an ISO of 12800 for low-light imaging.
Sony has incorporated its renowned Handycam recording technology into the Sony Xperia Z3 for you to take stunning 4K resolution shots on your phone. It comes with a SteadyShot technology to remove any blur while recording and Intelligent Active mode that estimates movements and analyzes frames for smoother, stable shots.
The Xperia Z3 allows you to take 4K resolution videos which are four times the detail compared to Full HD 1080p image quality. This results in unparalleled high definition images which are full of authentic details. You can even use an MHL 3.0 connector to connect to a 4K projector.
The Xperia Z3 comes with a number of fun apps that lets your creative juices flowing. These apps allow you to edit your photos and videos. Apart from the pre-installed apps, you can download more apps online.
If you ever get interrupted while playing on your PS4, simply plug your Sony Xperia Z3 into the remote controller to seamlessly switch from your PS4 to your phone. You can even connect the Z3 to your home WiFi to play games using PS4's DUALSHOCK 4 controller.
The Xperia Z3 has been crafted to fit a massive 3100 mAh battery which gives you up to 2 days of usage time. With the Sony Xperia Z3, you will never have to worry about recharging your phone.
This smartphone comes with an Ultra STAMINA mode that will help you limit your phone to its core functions, allowing you to squeeze every drop out of your phone's battery.
If you want to let your phone last extra long, switch to the phone's Extended standby mode and get up to four times the battery. When the screen is off, all other apps will be turned off automatically, allowing you to get more out of your phone's battery. You can also switch to the extended usage mode for an extra 14% of usage time.
The Sony Xperia Z3 comes with a Quad Core Qualcomm Snapdragon 801 processor. It also has 3 GB of RAM and comes with a Krait 400 CPU that has a clock speed of 2.5 GHz. It also comes with the industry's only 3rd Generation LTE/4G modem, allowing you to have blazing quick Internet connections with download speeds that are incredibly fast.
This phone comes with a Sony's intuitive contrast enhancement technology that makes images on your phone look even more sharp and bright in sunlight. The phone also has an In-Plane Switching technology which allows for super sharp images and true-to-life colors.
Normally seen in Sony's BRAVIA televisions, the Xperia Z3 also comes with a TRILUMINOS display technology that creates a wide palette of colors to enhance your viewing pleasure. This technology uses LEDs that create a brighter and more uniform light to capture the true color of the source.
1. Pixel Reduction technology examines each pixel in an image and reproduces the ones that are lacking. 2. Enhances elements to help to sharpen the image. 3. The Intelligent Image Enhancer reproduces the vividness of the image in its true color. 4. Intelligent Noise Reduction decreases the noise that can occur in high-motion scenes.
This phone comes with a Digital Sound Enhancement Engine that allows you to get more out every beat and note. It also has High Resolution Audio which makes it sound like you are in a recording studio.
This phone comes with a lot of connectivity features that allow you to pair your phone with a lot of other devices.


In the wake of the powerful earthquake that struck central Italy on Wednesday, Pope Francis at the General Audience postponed his prepared catechesis, and led the faithful gathered in St Peter's Square in the recitation of the Sorrowful Mysteries of the Most Holy Rosary.
The Holy Father expressed his "heartfelt sorrow and spiritual closeness" to all those affected by the earthquake and its aftershocks. He said he was deeply saddened upon learning several children were among the dead, and of hearing of the total destruction of the town of Amatrice.
"I want to assure all the people of Accumuli, Amatrice, the Diocese of Rieti, Ascoli Piceno, and all the people of Lazio, Umbria, and Le Marche, of the prayers and close solidarity of the entire Church, who in these moments extends her merciful love, as well as the concern of all of us here in the Piazza," Pope Francis said.
"I had prepared the catechesis for today, as for all Wednesdays during this year of mercy, focusing on the closeness of Jesus. However on hearing of the news of the earthquake that has struck central Italy, and which has devastated entire areas and left many wounded, I cannot fail to express my heartfelt sorrow and spiritual closeness to all those present in the zones afflicted.
"I also express my condolences to those who have lost loved ones, and my spiritual support to those who are anxious and afraid. Hearing the mayor of Amatrice say that the town no longer exists, and learning that there are children among the dead, I am deeply saddened.
"For this reason, I want to assure all the people of Accumuli, Amatrice, the Diocese of Rieti, Ascoli Piceno, and all the people of Lazio, Umbria, and Le Marche, of the prayers and close solidarity of the entire Church, who in these moments extends her merciful love, as well as the concern of all of us here in the Piazza.
"And thanking all the volunteer and rescue personnel who are assisting these people, I ask you to join me in praying to the Lord Jesus, Who is always moved by compassion before the reality of human suffering, that He may console the broken hearted, and through the intercession of the Virgin Mary, bring them peace.
"With Jesus let our hearts be moved with compassion.


text:
Q: I get "Encoding scheme `TU' unknown." error when I use the Turkish Journal of Mathematics. How to solve this? I am writing a manuscript using the Turkish Journal of Mathematics which is obtained from http://journals.tubitak.gov.tr/math/index.htm;jsessionid=D15895BC817F9481A9BEA2BAA5C33E04. Here is my working trial:
\documentclass{math}
\usepackage{hyperref}
\hypersetup{
colorlinks=true,
urlcolor=blue,
citecolor=blue}
\usepackage[all]{xy}
\usepackage{amsfonts,amssymb,amsmath,amsgen,amsopn,amsbsy,theorem,graphicx,epsfig}
\usepackage{amscd,bezier,latexsym,mathrsfs,enumerate,multirow}
\usepackage[utf8]{inputenc}\usepackage[english]{babel}
\usepackage[dvipsnames]{xcolor}
\usepackage{academicons}
\definecolor{orcidlogocol}{HTML}{A6CE39}
\usepackage[pagewise]{lineno}
\linenumbers

\yil{}
\vol{}
\fpage{}
\lpage{}
\doi{}

\title{Manuscript template: Full title must be in sentence case \\
\textcolor{red}{\footnotesize  The first page should contain the full title in sentence case (e.g., Multiplication modules with Krull dimension)}}

\author[AUTHOR and AUTHOR]{
\textbf{First AUTHOR$^{1}$\thanks{Correspondence: math@tubitak.gov.tr}~\href{https://orcid.org/XXXX-XXXX-XXXX-XXXX}{\orc},
Second AUTHORP$^{1,2}$\href{https://orcid.org/XXXX-XX12-3456-789X}{\orc}}\\
\textcolor{red}{The
full names (last names fully capitalised) and affiliations (in English) of all authors}\\
$^{1}$Department, Faculty, University, City, Country\\
$^{2}$Department of Mathematics, Faculty of Science, \.{I}zmir Institute of Technology,
\.{I}zmir, Turkey\\
\textcolor{red}{(Department, Faculty, University, City,
Country), and the contact e-mail address for the clearly identified}\\
\textcolor{red}{corresponding author.}
\\ [1.8em]

\rec{.201}
\acc{.201}
\finv{..201}
}

\amssayisi{2010 {\itshape AMS Mathematics Subject Classification:} 23584 \textcolor{red}{(Each manuscript should be accompanied by classification numbers from the American
Mathematical Society classification scheme.)}
\newline
\vspace{-15mm}
\begin{center}
         \raisebox{-17ex}[0ex][0ex]{~~ \raisebox{.5ex}[0ex][0ex]{\footnotesize  This work is licensed under a Creative Commons Attribution 4.0 International License.}}
            \end{center}}

\input{math.tex}

\setcounter{page}{1}
\begin{document}

\maketitle

\begin{abstract}The abstract should provide clear information about the research and the results obtained, and should not exceed 200 words. The abstract should not contain citations.

\keywords{Please provide key words or phrases to enable retrieval and indexing. Acronyms should be avoided.}
\end{abstract}

\section{Introduction}

\end{document}

However, when I try to run it, I get the error that says:

Encoding scheme `TU' unknown.

The error that I get looks like this:

A: I couldn't reproduce your script since you didn't provide math.cls. However, I have a suggestion to solve the problem of encoding in academicons. Although I used luatex or xetex, I got the same encoding error. I solved it by forcing the encoding:
\usepackage[TU]{fontenc}

That fixed it but I guess that it is a dirty hack. Any complete answer or background information on the encoding of fonts is welcome.

A: If you want to use the ORCID logo, you need to compile the document with XeLaTeX or LuaLaTeX.
Otherwise, you need to produce the logo as a standalone PDF, say with
\documentclass{standalone}
\usepackage{academicons,xcolor}
\definecolor{orcidlogocol}{HTML}{A6CE39}

\begin{document}

\textcolor{orcidlogocol}{\aiOrcid}

\end{document}

Save the above file as orcidlogo.tex and compile it with XeLaTeX. Then you can modify your document as
\documentclass{math}
\usepackage[all]{xy}
\usepackage{amsfonts,amssymb,amsmath,amsgen,amsopn,amsbsy,theorem,graphicx,epsfig}
\usepackage{amscd,bezier,latexsym,mathrsfs,enumerate,multirow}
\usepackage[utf8]{inputenc}\usepackage[english]{babel}
\usepackage[dvipsnames]{xcolor}
%\usepackage{academicons}
%\definecolor{orcidlogocol}{HTML}{A6CE39}
\usepackage[pagewise]{lineno}
\usepackage{hyperref}
\hypersetup{
colorlinks=true,
urlcolor=blue,
citecolor=blue}

\linenumbers

\yil{}
\vol{}
\fpage{}
\lpage{}
\doi{}

\renewcommand{\orc}{\includegraphics[height=\fontcharht\font`A]{orcidlogo}}

\title{Manuscript template: Full title must be in sentence case \\
\textcolor{red}{\footnotesize  The first page should contain the full
  title in sentence case (e.g., Multiplication modules with Krull dimension)}}

\author[AUTHOR and AUTHOR]{
\textbf{First AUTHOR$^{1}$\thanks{Correspondence: math@tubitak.gov.tr}~%
  \href{https://orcid.org/XXXX-XXXX-XXXX-XXXX}{\orc},
Second AUTHORP$^{1,2}$\href{https://orcid.org/XXXX-XX12-3456-789X}{\orc}}\\
\textcolor{red}{The
full names (last names fully capitalised) and affiliations (in English) of all authors}\\
$^{1}$Department, Faculty, University, City, Country\\
$^{2}$Department of Mathematics, Faculty of Science, \.{I}zmir Institute of Technology,
\.{I}zmir, Turkey\\
\textcolor{red}{(Department, Faculty, University, City,
Country), and the contact e-mail address for the clearly identified}\\
\textcolor{red}{corresponding author.}
\\ [1.8em]

\rec{.201}
\acc{.201}
\finv{..201}
}

So long as the orcidlogo.pdf file is in the same folder as your main document, you'll be OK.
However, I'd just type in the URL and leave the final job to the journal copy editors.

Note. The list of loaded packages is quite long and full of obsolete or deprecated packages; in particular epsfig, latexsym, bezier should be removed. Also amsfonts is already loaded by amssymb; amsgen, amsopn and amsbsy are not needed because loaded by amsmath; amscd is useless because you load xy that produces much better diagrams. Finally, theorem would not be my choice for managing theorem-like environments.

redpajama_set_name: RedPajamaStackExchange


Here is how I fixed the broken Glove Box Handle.
I took the glovebox out if the car because it was too cold to do it outside.
To remove it, remove the torx head screws around the outside edge, then remove the hidden one under the 'air bag' sticker and pull it out.
First picture is how to open the door when it is broken.
After taking the glovebox lid off, just to make it easier.
Drill a couple of pilot holes through the broken handle, and mark on the catch where it broke off. Pilot the catch and screw handle in place using 2 self-tapper screws. You need screws about 35mm long.
So, it's fixed, and is now probably stronger than when new.
You could do this as a preventive measure.
Just take the glovebox out of the car, lift the handle like you would to open the door. Drill a pilot hole in the middle (just as in the pictures above) and pop a self-tapper in.
This should secure it, and stop it snapping off.


text:
Author: Kat Yares
Boris Becker knows location of his Wimbledon
By Kat Yares
The three-time Wimbledon winner Boris Becker no longer knows where his trophies are from the All England Club. That explained the 54-year-old on Tuesday before the jury in the Southwark Crown Court. He would present the trophies "tomorrow" if that was possible, Becker explained against him as part of the process.
According to own information, he sold his real estate to be able to be able to be relieved, from "many" of his trophies and other memories from his career would now also lack some. "For a player, it's about winning the title. The trophy itself is less important if you play," Becker said. But today he wishes to have them still in his possession, "to show them to my children".
To the trophies he should not have handed over as agreed after his bankruptcy 2017, two of his three Wimbledon individual titles as well as his Olympiagold in the double of 1992 and the Trophies of Australia Open of 1991 and 1996.
* DTB must ran in Kazakhstan on sand
* Top sport live on Dazn. Register now! Can be terminated at any time monthly.
The process against the Tennisidol has been running for over a week. Becker, who won six Grand Slam tournaments in his sports career, is accused of a lack of cooperation in his insolvency proceedings. At a conviction, the election London threatens up to seven years imprisonment. He rejects the allegations.

redpajama_set_name: RedPajamaCommonCrawl


text:
Kinsmen Club of Kingston v. Walker (2004) 69 O.R. (3d) 453 (C.S.)
Kinsmen Club of Kingston, c.o.b. as The Summerhill Apartment et al. v. Walker
Kinsmen Club of Kingston, c.o.b. as The Summerhill Apartment et al. v. Walker; The Personal Insurance Company of Canada, Third Party
[Indexed as: Kinsmen Club of Kingston (c.o.b. Summerhill Apartment) v. Walker]
[2004] O.J. No. 137
Court File Nos. 00-CV-14540 and 02-CV-21421
R. Smith J.
Civil procedure — Discovery — Deemed undertaking — Plaintiff examining defendant's litigation guardian for discovery in action for damages caused by fire — After examination for discovery, plaintiff suing Litigation Guardian personally for negligence — Action against litigation guardian a breach of deemed undertaking — Action against litigation guardian permanently stayed — Rules of Civil Procedure, R.R.O. 1990, Reg 194, Rule 30.1.
The plaintiff Kinsmen Club of Kingston owned an apartment building in Kingston, Ontario. On July 25, 1999, a fire occurred in the apartment occupied by the late Mary Walker, who was 86 years old at the time. On July 24, 2000, the plaintiff sued Mary for damages claiming that she had caused the fire by careless smoking. Mary's son Donald agreed to act as litigation guardian. In Mary's statement of defence, it was pleaded that at the time of the fire Mary suffered from a mental disability that prevented her from forming the intention to act or from appreciating any duty of care. On May 13, 2002, Donald was examined for discovery as litigation guardian. Before the examination, Donald was not advised that counsel for the plaintiff was of the opinion that if Mary was not responsible for the plaintiff's losses, then Donald might be. After the discovery, on July 31, 2002, the plaintiff sued Donald for negligence. Donald moved to have the action stayed as an abuse of process due to the breach of the implied undertaking rule. [page454]
Held, the plaintiff's action should be permanently stayed.
Rule 30.1.01(3) prevents parties to an action or their counsel from using evidence or information obtained through examinations for discovery or documentary discovery, for purposes other than those of the proceeding in which the evidence was obtained. In this case, the evidence obtained from the discovery of Donald, in his capacity as litigation guardian for Mary, can only be used in the action against Mary unless leave of the court is obtained. Donald had status to move for a stay or a dismissal of the action commenced against him, as the plaintiff breached the deemed undertaking rule. In the circumstances of this case, the plaintiff should not be granted relief from the provisions of the deemed undertaking rule. If a party intends to use the evidence to be given by a litigation guardian in examinations for discovery, as the basis for a separate action against the litigation guardian personally, fairness requires that notice be given before the litigation guardian is examined. The action against Donald should be permanently stayed as an abuse of the court's process due to the breach of the implied undertaking rule.
Disher v. Kowal (2001), 56 O.R. (3d) 329, 14 C.C.E.L. (3d) 63 (S.C.J.); Goodman v. Rossi (1995), 24 O.R. (3d) 359, 125 D.L.R. (4th) 613, 12 C.C.E.L. (2d) 105, 37 C.P.C. (3d) 181 (C.A.), revg (1994), 21 O.R. (3d) 112, 120 D.L.R. (4th) 557, 7 C.C.E.L. (2d) 188, 34 C.P.C. (3d) 18 (Div. Ct.)
Rules and regulations referred to
Rules of Civil Procedure, R.R.O. 1990, Reg. 194, rules 7.03, 30, 31, 30.1
MOTION to have an action stayed for breach of the deemed undertaking under Rule 30.1 of the Rules of Civil Procedure, R.R.O. 1990, Reg. 194.
J. Stephen Cavanagh and Heather J. Williams, for plaintiffs.
John P. Lundrigan, for defendant Mary Walker. Michael Van Dusen, for defendant Donald S. Walker.
Lawrence Elliott, for The Personal Insurance Company of Canada.
SMITH J.: —
[1] The Kinsmen Club of Kingston ("Kinsmen") claim that Mary Walker ("Mary"), an 86-year-old resident of their apartment building, caused a fire by careless smoking and is responsible for the damages incurred. In her defence, Mary pleaded that she suffered from a mental disability which prevented her from forming the required intent or appreciating a duty of care.
[2] Mary's son, Donald Walker ("Donald"), had previously been appointed as his mother's power of attorney and, as a result, Donald was asked and agreed to act as his mother's Litigation Guardian. [page455]
[3] Donald was examined, as the Litigation Guardian for his mother, by counsel for the Kinsmen. Donald gave answers to questions during the examination for discovery, which the Kinsmen seek to rely on as the basis for a separate claim against Donald personally. The Kinsmen claim that if Mary lacked the necessary mental capacity, then Donald is personally responsible for the damages caused by his mother's careless smoking.
[4] The court must decide if the Kinsmen can use the evidence given by Donald in discovery, when he was examined as the Litigation Guardian for his mother, as the basis for a separate claim against Donald personally or does the deemed undertaking rule prevent the Kinsmen from using the evidence obtained at discovery in a separate proceeding?
Issue Number 1: Can the Kinsmen Club use the answers given by Donald during his discovery, in his capacity as Litigation Guardian for his mother, as the basis for a separate claim against him personally, or does this breach the deemed undertaking rule as set out in rule 30.1.01(3)?
[5] Both actions arise out of a fire that occurred on July 25, 1999, at the Summerhill Apartments located in Kingston, Ontario, which are owned by the Kinsmen Club of Kingston, who are the plaintiffs in this action. The apartment was occupied by the late Mary Walker ("Mary"), who was 86 years old, at the time of the loss.
[6] On July 24, 2000, the plaintiffs commenced the first action against Mary, claiming that she caused the fire in her apartment by careless smoking. In her Statement of Defence, Mary pleaded that, at the time of the fire, she suffered from a mental disability, which prevented her from forming the intention to act or from appreciating any duty to take care.
[7] Donald Walker ("Donald") had previously been appointed as power of attorney for his mother and due to her mental disability at the time the claim was made, Donald agreed to act as the Litigation Guardian for his mother. In support of that appointment, Donald swore an affidavit, in which he deposed that he had no interest in the proceeding, which was adverse to that of his mother.
[8] On May 13, 2002, Donald was examined by counsel for the Kinsmen, as the Litigation Guardian on behalf of his mother.
[9] Counsel for the Kinsmen, who conducted the examination for discovery of Donald, as Litigation Guardian, confirmed the following: [page456]
(a)That prior to the examination of Donald, he had formed the following opinions:
(i) Mary's defence of mental disability was one that was tenable at law, if the evidence supported it.
(ii) That if Mary was not responsible, that someone else must be responsible for her actions.
(iii) That Donald Walker himself may have been one of the persons that might be responsible for Mary's actions.
(b)No steps had been taken to initiate a claim against Donald, prior to his examination as Litigation Guardian for his mother.
(c)The information obtained from the examination of Donald, as Litigation Guardian for his mother, formed a good part of the information on which he relied in advancing the claim against Donald personally.
(d)All of the information obtained in the first action by the Kinsmen is the information upon which the plaintiffs made the decision to issue the second action against Donald.
(e)At no time prior to examining Donald, as Litigation Guardian for his mother, did counsel for the Kinsmen give notice to Donald or counsel for Mary of his view that Donald might be personally responsible for the fire in the event that Mary's defence of mental instability was upheld.
(f)Some of the questions put to Donald, as a Litigation Guardian, also shed light on Donald's personal role in Mary's case. Examining Donald's personal role was part of the purpose counsel for the Kinsmen had in asking Donald some of the questions in discovery.
[10] On July 31, 2002, after the examination of Donald was completed, the Kinsmen issued a second Statement of Claim, naming Donald as the sole defendant and claiming that he was responsible for the damages caused by his mother. In the Statement of Claim, the plaintiffs allege that Donald had assumed responsibility for his mother's care and that if Mary was not liable for her own actions, then Donald was personally liable for his mother's negligent acts. [page457]
[11] The deemed undertaking rule is set out in rule 30.1.01(3) [Rules of Civil Procedure, R.R.O. 1990, Reg. 194], which states as follows: 30.1.01(3) All parties and their counsel are deemed to undertake not to use the evidence or information to which this rule applies for any purposes other than those of the proceeding in which the evidence was obtained.
[12] Rule 30.1.01(1) of the Rules of Civil Procedure states that the deemed undertaking rule applies to evidence obtained on examinations for discovery (Rule 31) and also to documentary discovery (Rule 30), and to information obtained from evidence therefrom.
Purpose of Proceeding
[13] The plaintiffs' first argument is that the second action, against Donald in his personal capacity, was commenced "for the purposes of the proceeding" against Mary and, therefore, the deemed undertaking rule does not apply.
[14] Rule 30.1.01(3) prevents parties to an action or their counsel, in this case the Kinsmen and their counsel, from using evidence or information obtained through examinations for discovery or documentary discovery, for purposes other than those of the proceeding in which the evidence was obtained. The plaintiffs seek to use the evidence given in discovery by Donald, as Litigation Guardian, in the proceeding commenced by the plaintiffs against Mary (action number 00-CV-14540) for the purpose of supporting a claim against Donald personally (action number 02-CV-21421).
[15] The proceeding against Donald personally, in action number 02-CV-21421, is a separate proceeding from the action commenced by the plaintiffs against Mary, in action number 00- CV-14540. The deemed undertaking rule is quite clear that a party cannot use evidence given during discovery for purposes other than those of the proceeding in which the evidence was obtained. In this case, the evidence obtained from the discovery of Donald, in his capacity as Litigation Guardian for Mary, can only be used in action number 00-CV-14540, the proceeding in which the discovery was conducted, unless leave of the court is obtained.
[16] The plaintiffs' purpose for commencing a second action against Donald personally is not the factor that the court must consider. The court must decide whether "evidence obtained at a discovery in one proceeding may be used in another proceeding". [page458] The rule clearly states that evidence given at discovery in one proceeding may not be used for purposes other than the proceeding in which the evidence was given and therefore cannot be used in other proceedings, without leave of the court.
[17] The leading case on the deemed undertaking rule is Goodman v. Rossi (1995), 24 O.R. (3d) 359, 125 D.L.R. (4th) 613 (C.A.), where the Court of Appeal for Ontario recognized the deemed undertaking rule in Ontario. Ms. Goodman was employed as a real estate agent by NRS Royal Realty Inc. and Mr. Rossi was the President of NRS Royal Realty Inc. Ms. Goodman's employment was terminated and she sued for wrongful dismissal. In the course of discoveries, NRS Royal Realty produced a report prepared by Mr. Rossi, which was sent to the Minister of Consumer and Commercial Relations. The report contained critical comments about Ms. Goodman's ethical behaviour. Ms. Goodman then commenced an action for defamation based on the report.
[18] The rationale for the rule was stated, at p. 371 O.R. of the Goodman decision as follows:
The rational basis for the rule is that where one party compels another, either by the enforcement of a rule of court or a specific order of the court, to disclose documents or information whether that other wishes to or not, the party obtaining the disclosure is given this power because the invasion of the other party's rights has to give way to the need to do justice between those parties in the pending litigation between them; it follows from this that the results of such compulsion should likewise be limited to the purpose for which the order was made, namely, the purposes of that litigation then before the court between those parties and not for any other litigation or matter or any collateral purposes: see, for example, per Lord Keith of Kinkel in Home Office v. Harman, [1983] 1 A.C. 280, 308.
[Emphasis in original omitted]
[19] The party obtaining disclosure of documents or information in a discovery is limited to using the information obtained for the purposes of the proceeding between those parties and may not use the information for any other litigation or matter or any collateral purpose. In this case, the plaintiffs seek to use information obtained on discovery in the first proceeding against Mary, in other litigation, namely, the subsequent action commenced against Donald. This is prohibited by the deemed undertaking rule.
[20] The second argument raised by the plaintiffs is that the moving party, Donald Walker, has no status to complain about [page459] the breach of the deemed undertaking rule, as he was not the party who was examined.
[21] Donald is the defendant in the second proceeding commenced by the plaintiffs. The deemed undertaking rule prevents a party from using evidence given at discovery for any other purpose other than the proceeding in which the discovery was conducted. The plaintiffs seek to rely on the evidence given by Donald, as Litigation Guardian for his mother in the first proceeding, as evidence to justify their claim against him personally in the second proceeding.
[22] The Rules of Civil Procedure do not contain a definition of the word "party". The Rules do not define a party as being limited to a plaintiff or defendant. In this case, Donald was a party to the first action, as his mother's Litigation Guardian. Donald became potentially liable for costs personally when he agreed to act as Litigation Guardian. Donald was named as a party in the first action by being named in the style of cause, as well as by becoming possibly liable for costs of the proceeding. Donald was a party to the first action against Mary in his capacity, as her Litigation Guardian.
[23] The deemed undertaking rule applies to the Kinsmen and their counsel, who are deemed to have undertaken not to use information obtained for any purpose other than that proceeding in which the discovery was conducted. The undertaking is deemed to be given by the party obtaining the information on discovery. In this case, the Kinsmen are clearly a party in the first action against Mary, who have received information from the discovery in the first action, and are bound by the deemed undertaking rule.
[24] Therefore, I find that Donald has status to move for a stay or a dismissal of the action commenced against him, as the plaintiffs have breached the deemed undertaking rule and seek to use evidence given in the discovery in the first proceeding, as the basis for a claim against Donald in a separate proceeding.
Issue Number 2: Do the interests of justice outweigh the prejudice that may be caused to the party disclosing evidence in this case?
[25] The plaintiffs' final argument is to seek relief from the provisions of the deemed undertaking rule. Rule 30.1.01(8) of the Rules of Civil Procedure states as follows: 30.1.01(8) If satisfied that the interest of justice outweigh any prejudice that would result to a party who disclosed evidence, the court may order that subrule (3) does not apply to the evidence or to information obtained from it, and may impose such terms and give such direction as are just. [page460]
[26] The Kinsmen chose not to give Donald notice that they considered that he was potentially personally responsible for Mary's actions before they examined him, as the Litigation Guardian for his mother. Counsel for the Kinsmen admitted that he had formed an opinion that Donald may have been one of the persons responsible for Mary's actions, prior to examining him for discovery.
[27] In order to be appointed as Litigation Guardian, rule 7.03(10)(h)(iii) requires Donald to swear an affidavit stating that he had no interest in the proceeding, adverse to that of the party under disability, namely, his mother. The evidence is clear that Donald did not appreciate that he potentially had an adverse interest to that of his mother, before he was examined, as the Litigation Guardian for his mother. The evidence is also clear that counsel for the plaintiffs was aware that Donald potentially had an interest adverse to his mother. Notwithstanding such knowledge, counsel for the Kinsmen proceeded to use the opportunity of examining Donald in his capacity, as Litigation Guardian in the first proceeding, to obtain information concerning Donald's possible personal liability for the negligent actions of his mother. Counsel's examination of Donald served two purposes; (1) to determine the extent of Mary's actions and her mental state and; (2) to discover the degree of responsibility that Donald had for his mother's actions.
[28] Counsel for the Kinsmen had other alternatives available to him. He could have advised Donald that his interest was potentially adverse to that of his mother and suggested he obtain independent legal advice. He could have issued the separate claim against Donald before examining him, however, the plaintiffs lacked the required evidence. Counsel for the plaintiffs was aware that Donald's interest was potentially adverse to his mother and, therefore, he could have advised Donald that he was not an appropriate Litigation Guardian. Counsel for the plaintiffs chose not to advise Donald of his potential adverse interest and proceeded to question Donald to explore the possibility of his personal responsibility without giving notice.
[29] I do not find that the interests of justice in this case outweigh the prejudice to the party who disclosed evidence; namely, Donald Walker. The actions of the plaintiffs, who chose to use the discovery process in the first proceeding as a means of obtaining information on which to commence a second proceeding against the party being examined, without giving prior notice to that party, is a practice which is not fair and just and should not be condoned by the courts. [page461]
[30] If a party intends to use the evidence to be given by a Litigation Guardian in examinations for discovery as the basis for a separate action against the Litigation Guardian personally, then fairness requires that notice should be provided to the Litigation Guardian before he or she is examined.
[31] In the case of Disher v. Kowal (2001), 56 O.R. (3d) 329, 14 C.C.E.L. (3d) 63 (S.C.J.), the defendant sought to dismiss the plaintiffs' action as an abuse of process because of non- compliance with the deemed undertaking rule in rule 30.1.01(3). Ms. Disher was a nurse at the North York General Hospital who was dismissed in 1992. In her wrongful dismissal action against the North York General Hospital, the hospital produced two copies of a memorandum from Ms. Kowal, another nurse at the hospital, expressing concerns about Ms. Disher's behaviour. Ms. Disher subsequently commenced an action against Ms. Kowal alleging injurious falsehood and intentional interference with economic relations. The plaintiff, Ms. Disher, sought relief from the deemed undertaking rule and the hospital opposed this motion. The court found that the Disher case was very similar to the Goodman case, where information was obtained during the wrongful dismissal action and used to initiate an action against an individual who was not a party to that action.
[32] The prejudice to Donald is that he was questioned in a manner where one of the objectives was to obtain self- incriminating statements from him. Donald agreed to act as his mother's Litigation Guardian because he had been named as his mother's power of attorney and because he was unaware that his interest could be adverse to that of his mother in the claim made by the Kinsmen against his mother. The Kinsmen argued that Donald could have refused to act as his mother's Litigation Guardian and therefore he was not compelled to give information, which might be prejudicial. Donald was unaware that his interest was adverse. If the plaintiffs had given him notice that he was possibly potentially responsible for his mother's actions, then this argument would have some merit.
[33] In the Disher case, the court stated that special circumstances were required before the court should depart from the deemed undertaking rule. I do not find that the interests of justice outweigh the prejudice to Donald in the circumstances of this case, where no notice was given to Donald that the information provided by him in discovery, as Litigation Guardian in the first proceeding, could be used as the basis for a subsequent claim against him personally. [page462]
Consequence of Breach and Timeliness
[34] If the Kinsmen have breached the deemed undertaking rule and relief from the deemed undertaking rule is not granted pursuant to rule 30.1.01(3), then it would constitute an abuse of process to allow the use of the plaintiffs' evidence or information obtained therefrom in a separate proceeding. In the Disher v. Kowal, supra, and Goodman v. Rossi, supra, decisions, the court granted a stay of the second action as a result of the breach of the implied undertaking rule.
[35] While there was some delay in bringing this motion, the factual situation was complex and no evidence has been produced to show that the delay has caused any prejudice to any party.
[36] I therefore find that the action number 02-CV-21421 commenced against Donald Walker personally is in breach of the implied undertaking rule set out in rule 30.1.01(3). I also find that relief from the deemed undertaking rule should not be granted, as the interests of justice do not outweigh the prejudice to Donald Walker for the reasons set out above.
[37] Action number 02-CV-21421 is therefore permanently stayed, as an abuse of the court's process due to the breach of the implied undertaking rule by the plaintiffs.
[38] It is not necessary to deal with the plaintiffs' motion to consolidate the actions in view of my decision on the deemed undertaking rule.
[39] In addition to the costs envelopes I have received and which should be provided to each party; the defendant shall have ten (10) business days to make submissions on costs and the plaintiffs shall have ten (10) business days to respond and the defendant shall have five (5) business days to reply.
Order accordingly. [page463]


text:
Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis: Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan
Tsutomu Takeuchi, Yoshiya Tanaka, Sakae Tanaka, Atsushi Kawakami, Yeong Wook Song, Yi Hsing Chen, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko
常任理事
Introduction: This final analysis of a long-term extension (LTE) study assessed the safety, tolerability, and effectiveness of peficitinib (ASP015K), a pan-Janus kinase inhibitor, in Asian patients with rheumatoid arthritis (RA). Methods: Patients had previously completed the 12-week phase 2b (RAJ1), or 52-week phase 3 (RAJ3 and RAJ4) peficitinib studies in Japan, Korea, and Taiwan, and received oral peficitinib 50 or 100 mg/day. Dose increase to 150 mg/day or reduction to 50 mg/day was permitted. Efficacy endpoints included American College of Rheumatology (ACR)20/50/70 response rates, 28-joint Disease Activity Score with C-reactive protein (DAS28-CRP), and ACR components. Safety endpoints included treatment-emergent adverse events (TEAEs), and incidence rates (IRs) of adverse events of special interest per 100 patient-years (PY). Results: Overall, 843 patients received peficitinib for a mean 32.0 months (maximum 85.2 months), and most (64.4%) received peficitinib 100 mg/day as a maximum dose. Respective ACR20/50/70 response rates were maintained from baseline (week 0 of LTE; 71.6, 52.1, and 34.7%) to end of treatment (78.7, 63.3, and 44.1%); continuous improvements in ACR components and DAS28-CRP were observed from the baselines of preceding studies and throughout the LTE. Overall, 796/843 (94.4%) patients experienced TEAEs; most were severity grade 1/2. Most common TEAEs were nasopharyngitis (47.0%) and herpes zoster (17.3%). Drug-related TEAEs leading to permanent discontinuation occurred in 140 (16.6%) patients, and IRs (95% confidence interval) per 100 PY of serious infections, herpes zoster-related disease, and malignancies were 2.7 (2.1, 3.4), 7.3 (6.2, 8.6), and 1.2 (0.9, 1.8), respectively. Two deaths occurred during the study; one each from diffuse large B cell lymphoma and pneumonia, which were, respectively considered probably and possibly related to study drug. Conclusions: Improvements in effectiveness variables were maintained during this long-term study of peficitinib in Asian patients with RA; peficitinib was generally well tolerated over a mean 32 months' duration. Trial Registration: ClinicalTrials.gov. NCT01638013, retrospectively registered on 11 July 2012 https://clinicaltrials.gov/ct2/show/NCT01638013.
Rheumatology and Therapy
リウマチ学
免疫アレルギー学
「Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis: Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。
peficitinib Medicine & Life Sciences 100%
Taiwan Medicine & Life Sciences 47%
Rheumatoid Arthritis Medicine & Life Sciences 40%
Japan Medicine & Life Sciences 40%
Rheumatology Medicine & Life Sciences 19%
Herpes Zoster Medicine & Life Sciences 13%
Takeuchi, T., Tanaka, Y., Tanaka, S., Kawakami, A., Song, Y. W., Chen, Y. H., Rokuda, M., Izutsu, H., Ushijima, S., & Kaneko, Y. (2021). Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis: Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan. Rheumatology and Therapy, 8(1), 425-442. https://doi.org/10.1007/s40744-021-00280-5
Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis : Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan. / Takeuchi, Tsutomu; Tanaka, Yoshiya; Tanaka, Sakae; Kawakami, Atsushi; Song, Yeong Wook; Chen, Yi Hsing; Rokuda, Mitsuhiro; Izutsu, Hiroyuki; Ushijima, Satoshi; Kaneko, Yuichiro.
In: Rheumatology and Therapy, Vol. 8, No. 1, 03.2021, p. 425-442.
Takeuchi, T, Tanaka, Y, Tanaka, S, Kawakami, A, Song, YW, Chen, YH, Rokuda, M, Izutsu, H, Ushijima, S & Kaneko, Y 2021, 'Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis: Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan', Rheumatology and Therapy, vol. 8, no. 1, pp. 425-442. https://doi.org/10.1007/s40744-021-00280-5
Takeuchi T, Tanaka Y, Tanaka S, Kawakami A, Song YW, Chen YH et al. Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis: Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan. Rheumatology and Therapy. 2021 3;8(1):425-442. https://doi.org/10.1007/s40744-021-00280-5
Takeuchi, Tsutomu ; Tanaka, Yoshiya ; Tanaka, Sakae ; Kawakami, Atsushi ; Song, Yeong Wook ; Chen, Yi Hsing ; Rokuda, Mitsuhiro ; Izutsu, Hiroyuki ; Ushijima, Satoshi ; Kaneko, Yuichiro. / Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis : Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan. In: Rheumatology and Therapy. 2021 ; Vol. 8, No. 1. pp. 425-442.
@article{12d04f5688d841199e1406b637be42da,
title = "Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis: Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan",
abstract = "Introduction: This final analysis of a long-term extension (LTE) study assessed the safety, tolerability, and effectiveness of peficitinib (ASP015K), a pan-Janus kinase inhibitor, in Asian patients with rheumatoid arthritis (RA). Methods: Patients had previously completed the 12-week phase 2b (RAJ1), or 52-week phase 3 (RAJ3 and RAJ4) peficitinib studies in Japan, Korea, and Taiwan, and received oral peficitinib 50 or 100 mg/day. Dose increase to 150 mg/day or reduction to 50 mg/day was permitted. Efficacy endpoints included American College of Rheumatology (ACR)20/50/70 response rates, 28-joint Disease Activity Score with C-reactive protein (DAS28-CRP), and ACR components. Safety endpoints included treatment-emergent adverse events (TEAEs), and incidence rates (IRs) of adverse events of special interest per 100 patient-years (PY). Results: Overall, 843 patients received peficitinib for a mean 32.0 months (maximum 85.2 months), and most (64.4%) received peficitinib 100 mg/day as a maximum dose. Respective ACR20/50/70 response rates were maintained from baseline (week 0 of LTE; 71.6, 52.1, and 34.7%) to end of treatment (78.7, 63.3, and 44.1%); continuous improvements in ACR components and DAS28-CRP were observed from the baselines of preceding studies and throughout the LTE. Overall, 796/843 (94.4%) patients experienced TEAEs; most were severity grade 1/2. Most common TEAEs were nasopharyngitis (47.0%) and herpes zoster (17.3%). Drug-related TEAEs leading to permanent discontinuation occurred in 140 (16.6%) patients, and IRs (95% confidence interval) per 100 PY of serious infections, herpes zoster-related disease, and malignancies were 2.7 (2.1, 3.4), 7.3 (6.2, 8.6), and 1.2 (0.9, 1.8), respectively. Two deaths occurred during the study; one each from diffuse large B cell lymphoma and pneumonia, which were, respectively considered probably and possibly related to study drug. Conclusions: Improvements in effectiveness variables were maintained during this long-term study of peficitinib in Asian patients with RA; peficitinib was generally well tolerated over a mean 32 months{\textquoteright} duration. Trial Registration: ClinicalTrials.gov. NCT01638013, retrospectively registered on 11 July 2012 https://clinicaltrials.gov/ct2/show/NCT01638013.",
keywords = "Herpes zoster, Janus kinase inhibitors, Long-term extension study, Peficitinib, Rheumatoid arthritis, Serious infection, Targeted synthetic DMARDs",
author = "Tsutomu Takeuchi and Yoshiya Tanaka and Sakae Tanaka and Atsushi Kawakami and Song, {Yeong Wook} and Chen, {Yi Hsing} and Mitsuhiro Rokuda and Hiroyuki Izutsu and Satoshi Ushijima and Yuichiro Kaneko",
note = "Funding Information: The authors would like to thank the patients involved in this study, the study investigators, and team staff. Sponsorship for this study and Rapid Service fee were funded by Astellas Pharma, Inc. Medical writing support was funded by Astellas Pharma, Inc. Medical writing support was provided by Anne-Marie Edwards, MChem, of Cello Health MedErgy (Europe), and funded by Astellas Pharma, Inc. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Publisher Copyright: {\textcopyright} 2021, The Author(s).",
journal = "Rheumatology and Therapy",
publisher = "Adis International Ltd",
T1 - Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis
T2 - Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan
AU - Takeuchi, Tsutomu
AU - Tanaka, Yoshiya
AU - Tanaka, Sakae
AU - Kawakami, Atsushi
AU - Song, Yeong Wook
AU - Chen, Yi Hsing
AU - Rokuda, Mitsuhiro
AU - Izutsu, Hiroyuki
AU - Ushijima, Satoshi
AU - Kaneko, Yuichiro
N1 - Funding Information: The authors would like to thank the patients involved in this study, the study investigators, and team staff. Sponsorship for this study and Rapid Service fee were funded by Astellas Pharma, Inc. Medical writing support was funded by Astellas Pharma, Inc. Medical writing support was provided by Anne-Marie Edwards, MChem, of Cello Health MedErgy (Europe), and funded by Astellas Pharma, Inc. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Publisher Copyright: © 2021, The Author(s).
N2 - Introduction: This final analysis of a long-term extension (LTE) study assessed the safety, tolerability, and effectiveness of peficitinib (ASP015K), a pan-Janus kinase inhibitor, in Asian patients with rheumatoid arthritis (RA). Methods: Patients had previously completed the 12-week phase 2b (RAJ1), or 52-week phase 3 (RAJ3 and RAJ4) peficitinib studies in Japan, Korea, and Taiwan, and received oral peficitinib 50 or 100 mg/day. Dose increase to 150 mg/day or reduction to 50 mg/day was permitted. Efficacy endpoints included American College of Rheumatology (ACR)20/50/70 response rates, 28-joint Disease Activity Score with C-reactive protein (DAS28-CRP), and ACR components. Safety endpoints included treatment-emergent adverse events (TEAEs), and incidence rates (IRs) of adverse events of special interest per 100 patient-years (PY). Results: Overall, 843 patients received peficitinib for a mean 32.0 months (maximum 85.2 months), and most (64.4%) received peficitinib 100 mg/day as a maximum dose. Respective ACR20/50/70 response rates were maintained from baseline (week 0 of LTE; 71.6, 52.1, and 34.7%) to end of treatment (78.7, 63.3, and 44.1%); continuous improvements in ACR components and DAS28-CRP were observed from the baselines of preceding studies and throughout the LTE. Overall, 796/843 (94.4%) patients experienced TEAEs; most were severity grade 1/2. Most common TEAEs were nasopharyngitis (47.0%) and herpes zoster (17.3%). Drug-related TEAEs leading to permanent discontinuation occurred in 140 (16.6%) patients, and IRs (95% confidence interval) per 100 PY of serious infections, herpes zoster-related disease, and malignancies were 2.7 (2.1, 3.4), 7.3 (6.2, 8.6), and 1.2 (0.9, 1.8), respectively. Two deaths occurred during the study; one each from diffuse large B cell lymphoma and pneumonia, which were, respectively considered probably and possibly related to study drug. Conclusions: Improvements in effectiveness variables were maintained during this long-term study of peficitinib in Asian patients with RA; peficitinib was generally well tolerated over a mean 32 months' duration. Trial Registration: ClinicalTrials.gov. NCT01638013, retrospectively registered on 11 July 2012 https://clinicaltrials.gov/ct2/show/NCT01638013.
AB - Introduction: This final analysis of a long-term extension (LTE) study assessed the safety, tolerability, and effectiveness of peficitinib (ASP015K), a pan-Janus kinase inhibitor, in Asian patients with rheumatoid arthritis (RA). Methods: Patients had previously completed the 12-week phase 2b (RAJ1), or 52-week phase 3 (RAJ3 and RAJ4) peficitinib studies in Japan, Korea, and Taiwan, and received oral peficitinib 50 or 100 mg/day. Dose increase to 150 mg/day or reduction to 50 mg/day was permitted. Efficacy endpoints included American College of Rheumatology (ACR)20/50/70 response rates, 28-joint Disease Activity Score with C-reactive protein (DAS28-CRP), and ACR components. Safety endpoints included treatment-emergent adverse events (TEAEs), and incidence rates (IRs) of adverse events of special interest per 100 patient-years (PY). Results: Overall, 843 patients received peficitinib for a mean 32.0 months (maximum 85.2 months), and most (64.4%) received peficitinib 100 mg/day as a maximum dose. Respective ACR20/50/70 response rates were maintained from baseline (week 0 of LTE; 71.6, 52.1, and 34.7%) to end of treatment (78.7, 63.3, and 44.1%); continuous improvements in ACR components and DAS28-CRP were observed from the baselines of preceding studies and throughout the LTE. Overall, 796/843 (94.4%) patients experienced TEAEs; most were severity grade 1/2. Most common TEAEs were nasopharyngitis (47.0%) and herpes zoster (17.3%). Drug-related TEAEs leading to permanent discontinuation occurred in 140 (16.6%) patients, and IRs (95% confidence interval) per 100 PY of serious infections, herpes zoster-related disease, and malignancies were 2.7 (2.1, 3.4), 7.3 (6.2, 8.6), and 1.2 (0.9, 1.8), respectively. Two deaths occurred during the study; one each from diffuse large B cell lymphoma and pneumonia, which were, respectively considered probably and possibly related to study drug. Conclusions: Improvements in effectiveness variables were maintained during this long-term study of peficitinib in Asian patients with RA; peficitinib was generally well tolerated over a mean 32 months' duration. Trial Registration: ClinicalTrials.gov. NCT01638013, retrospectively registered on 11 July 2012 https://clinicaltrials.gov/ct2/show/NCT01638013.
KW - Herpes zoster
KW - Janus kinase inhibitors
KW - Long-term extension study
KW - Peficitinib
KW - Rheumatoid arthritis
KW - Serious infection
KW - Targeted synthetic DMARDs
JO - Rheumatology and Therapy
JF - Rheumatology and Therapy


Ala. Rep. Barry Moore (R – Coffee) is seen as one of the rising stars out of a class of freshman legislators who rode into office on the 2010 Republican wave. He was even recently labeled as the most conservative legislator in the state of Alabama by Cliff Sims, founder and publisher of political blog Yellowhammer News.
Recently, information has come to light that Moore, owner of Barry Moore Industries, had a longstanding business relationship with Yellowhammer's Sims prior to receiving this accolade, misrepresented his residence on an application to Enterprise Country Club in order to receive a discount, and threatened the creation of 100 local jobs if his opponent did not withdraw from his house race.
One hundred jobs in Enterprise would be jeopardized if Josh Pipkin, candidate for State House District 91, did not withdraw his candidacy. That is what Alabama Rep. Barry Moore told Pipkin, according to records obtained by The Enterprise Ledger.
The first recorded cell phone conversation between Moore and Pipkin occured June 22, 2013. It was one of multiple conversations the two had where Moore attempted to pressure Pipkin against running.
As reported by the Southeast Sun, Enterprise State Community College was set to receive an unmanned, aerial systems program, and $2 million in State funds were to be used to purchase a building for it. The result would be 100 new, highly-skilled jobs for Enterprise.
A full transcript of Moore's conversation with Pipkin can be read at The Enterprise Ledger.
On November 26, 2013, Cliff Sims, founder and publisher of conservative political blog Yellowhammer News called Moore the most conservative legislator in the state of Alabama.
Sims and Rep. Moore's ties go beyond the blog's endorsement. Moore co-owns a Birmingham address with Sims as an investment. Sims did not disclose this information in the article published on Yellowhammer.
Moore applied for membership to the Enterprise Country Club and listed the Birmingham address on his application for an "out of town" payment plan. Moore's official residency is 139 Club Way, Enterprise, Alabama 36330, according to the State's website.
A Birmingham member would receive a 50% discount on the $200 monthly rate charged to Enterprise members, according to a staff member at the club. This calculates to a $1,100 annual difference.
Enterprise Country Club manager Jennifer Dawkins confirmed that despite Moore's application, he ended up paying the full membership fee. According to Moore, he is no longer a member.
Multiple political insiders have stated they have seen Moore entering and exiting the courthouse in Lee County, where a special grand jury has been convened to investigate corruption and unethical behavior among elected officials. Yesterday, Rep. Greg Wren resigned from office and pleaded guilty to knowingly using his public office for personal gain.
Wren accepted a plea agreement from the Attorney General's office and has agreed to assist them in the ongoing investigation.
Moore and Pipkin will square off in the Republican primary on June 3rd.
UPDATED 10:20am Saturday, April 5. Information on the purchase of Rep. Moore's home by Enterprise Electronics Corporation was removed after it was revealed that there were multiple evaluation reports evaluating the worth of Moore's home higher than originally reporter.


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text:
Book Review: Spook Light Chronicles Vol. 3
Book Review Spook Light Chronicles Vol. 3: We Always Lie to Strangers By Lara Shipley and Antone Dolezal Reviewed by Colin Pantall "I guess I keep coming back out here for something. For the life of me I don't know what." –from the start of the first volume of Lara Shipley and Antone Dolezal's Spook Light Chronicles
By the end of that volume, the question is answered.
Spook Light Chronicles Vol. 3: We Always Lie to Strangers.
By Lara Shipley and Antone Dolezal, Search Party Press, 2014.
The Spook Light Chronicles: Thankful for a chance to say goodbye
A review by Colin Pantall
Spook Light Chronicles Vol. 3: We Always Lie to Strangers
Photographs by Lara Shipley and Antone Dolezal.
Search Party Press, 2014. 60 pp., 52 color illustrations, 7x9".
"I guess I keep coming back out here for something. For the life of me I don't know what." –from the start of the first volume of Lara Shipley and Antone Dolezal's Spook Light Chronicles
By the end of that volume, the question is answered. The reason she or he keeps coming back to the dark woods of the Ozarks is the Spook Light, a light that comes out at night to haunt the locals. What is this Spook Light? Is it a natural, man-made or supernatural phenomenon? Is the mysterious light that floats along the Bible Belt hotspot of Devil's Promenade really Satan in disguise, or is it car lights from Route 66 reflected through the forests and the glades, or is it a manifestation of the spiritual baggage that weighs so heavy on the few souls who live in this isolated corner of the United States?
Spook Light Chronicles Vol. 3: We Always Lie to Strangers. By Lara Shipley and Antone Dolezal, Search Party Press, 2014.
The story of the Spook Light is the subject of The Road and the Light, the first volume of the Spook Light Chronicles and it's a story told beautifully using multiple voices, contemporary images and all kinds of archive material that may or may not be as old or authentic as they seem.
The second volume is called The Phosphorescent Man; it tells the story of the industry that has built up around the Spook Light, the museums and guides who sell its story to gullible incomers. These guides who hover between fact, fiction and fabrication in their attempts to make a hard-earned buck. But beneath the myths and the legends looms a disturbing fact; that perhaps the Spook Light is real, that this soul-sucking light really is the devil made light.
The final volume, We Always Lie to Strangers brings us to the present and ties up the loose ends in a form where myth becomes documentary, and documentary becomes myth. There are eight short texts accompanied by an illustrative series of images that build up into an over reaching narrative of a land where loyalties, customs and beliefs have roots in something that goes deeper than the soil. It's a fiction that is a documentary; it tells the story of the soul of the landscape, of what it feels like to be here, to live here, to belong here. And it does it in a most engaging manner. Reading through these three volumes, one is not weighed down with the labor of making sense of it all. It's smart, sharp and human. It's a proper story, in other words, a story that is beautifully told through both words and pictures.
"This country used to be full of lights," the final volume begins. "Seemed like every town had one, and not just lights but other strange things… Now you don't hear about that stuff anymore. Most of the towns are gone and the lights and everything else gone with them."
So it's a story of dereliction and emptiness. The lights might be gone, but there's a feeling that there's a vacancy in this lonely meeting place of Missouri, Kansas and Oklahoma. We see Chris from Arizona on a derelict basketball court. He's an outsider because he wasn't born there and he's sweeping the court in the hope that he'll turn the "…cracked and overgrown basketball court into a skate park. He dreams that when it's finished other kids will come, and then he will have friends. He is not yet aware that none of the neighbour kids will know how to skate or will even own boards or care."
Or there's the Mennonite boy who talks about what it's like to grow up in this community. He's asked about Mennonite folk stories, but they don't have any. "If a Mennonite tells a story," he says, "then the story is true." We discover that the boy is happy. He enjoys swimming in the river, but it's a happiness tinged with melancholy, a closed happiness.
The mix of the fervently religious and the supernatural bubble beneath the surface. We hear of the faceless woman who appears by a river; "…don't look into her faceless face or you too will be forever gone," we are warned. And there to tie us back into an Ozarkian reality is Jeannie, a woman who knits masks in her free time. "When she wears one, she is her most comfortable. She can see you, but you can't see her."
There's a Bacchanalian dance where a Creedence Clearwater Revival tune sets the crowd alight, a man clutches the breast of a woman who "…for twenty minutes, attempting a line dance, drew a square on the ground with her foot."
At a thinly attended revival meeting, a chain-shaking preacher lays hands on the swollen leg of Tim, a man who "doesn't trust doctors" and is scared they will amputate his leg. "You don't need a doctor," the preacher tells him. Throughout the book, people are possessed; pulses race and if they're not praising the lord, they're beating snakes to death with lead piping and telling their women that they have a "demonic possession."
And the demons are there; they're in the faceless woman who appears by the river and they're in the "Booger Dog," the hellhound of the Ozarks which "roams the place that connects our world to the other, stealing souls for the underworld." An old lady tells of how she saw him one night, standing beside the wartime sweetheart who had disappeared three months before. "There was something funny in his gaze – like he was looking both at her and another place simultaneously. It was the last chance she saw him, and she was thankful to the Dog for chance to say goodbye."—COLIN PANTALL
COLIN PANTALL is a UK-based writer and photographer. He is a contributing writer for the British Journal of Photography and a Senior Lecturer in Photography at the University of Wales, Newport. http://colinpantall.blogspot.com
Labels: Book Reviews, Books, Colin Pantall


DEAR DEIDRE: MY best mate is starving herself on just 100 calories a day.
I would tell her parents but I fear she might end our friendship. She's my only pal.
She started cutting back on food when a boyfriend left her, saying she was fat. She isn't.
She's a size eight at most.
She wears baggy clothes but I know from her Instagram pictures she's skeletal. We are both 18 and in college.
DEIDRE SAYS: It sounds as if she is anorexic. This is a potentially fatal illness and is not something you can handle on your own.
Tell her you are worried about her and encourage her to find help through her GP and/or Beat (beateatingdisorders.org.uk).
It has a special helpline for young people on 0808 801 0711.
If she fails to quickly act on that, share your worries about her with the tutor at your college who is responsible for student welfare.
READ TODAY'S DEAR DEIDRE What if the online girl I'm meant to be meeting isn't who she says she is?


text:
Frybread: Past, Present & Future
Have you ever had frybread, beaver tails, bannock bread at a Native American (Indian) Powwow/Gathering? Ever wonder where it came from? It's Hidden History? The controversial background of it? How you can make or have it at home? Here's the Book you need. The only book ever written (that we know of) that has the history, over 200 recipes, culture, historical timeline, the health ramifications, Diabetes (including contact information for help with Diabetes), exchange tables, conversion charts, information on oils and fats for frying and the health aspects of the oil and other ingredients! A step by step photo guide to make your own frybread. Substitution tables to help make healthier frybread. Charts and tables to increase or decrease the size of your favorite recipe. Ever wonder how many teaspoons are in a cup? It's in this book! Want to use something other than buttermilk in your frybread? It's in here! Info on songs, art, stories and poetry about frybread? It's in here. If you ever wanted to know anything about Frybread, it's most likely in this book. A portion of the proceeds from the sale of this book is donated to Diabetes and health programs for Native peoples, specifically programs for children, when possible.
Publisher: CreateSpace Independent Publishing Platform; 1 edition (June 3, 2014)
Best Sellers Rank: #864,592 in Books (See Top 100 in Books) #44 in Books > Cookbooks, Food & Wine > Regional & International > Native American
excellent experience, great seller!
Easy to use cookbook.
Excellent reference book with a variety of frybread recipe from different Native American cultures. I really liketheconversions for gluten free folks. All in all,it is a keeper!
Great recipes
A gift, but sounds interesting.
Excellent book includes an amazing history as well as plenty of recipes!
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