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June Lake Hiking
SALT LAKE CITY, Utah (News4Utah. The deliberations will happen in public work sessions every Tuesday through mid-June when the final budget is adopted.
Liberty Lake has a sign up at the county park saying that there was a bear sighting on June 22 on the Edith Hansen trail. Ryan Whitted brings bear spray with him whenever he goes hiking. "I carry it s.
Yet he allowed a 23 percent rate hike. Now he says the way to save money is to remove. Putting money over people might wor.
PORTAGE COUNTY, OH (WOIO) – Portage County Sheriffs are investigating a violent attack on the Deerfield Berlin Lake Hike and Bike Trail last night. The first incident happened in June. Anyone who w.
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Our trip was the first week of June. For being relatively early in the summer. The ranger recommended a 3-mile loop that would take me to Swan Lake and Heron Pond. The Falcon Guide hiking book for.
"Construction is nearing completion on (the) Washington Street Thoroughfare Project in central Lake County," read the invite from the. for both bike riders and pedestrians. According to a June 2017.
Geese like to use the lake, people like to use the lake for fishing and hiking around it. Volunteers and DPW staff. was on.
The challenge began at 2 a.m. Thursday, June. hikes, for sure, is the south ridge of Champlain [Mountain]. It's absolutely gorgeous. That's a pretty popular one you can do. And I also really like N.
Lane figured 500 to 1,000 hike to Donut Falls on busy days, and the parking areas at Albion Basin trailheads often are full on weekends. The agency counted 70,000 people last year passing through the.
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Mineral Area College's Modern Foreign Language chairperson is helping organize a trip to Costa Rica from June 3-12 that inclu.
The Connecticut Water Company and the Shenipsit Lake Association (SLA. CFPA's 2016 "Connecticut Trails Day" and will host a guided hike of a portion of the hiking trail on Saturday, June 4, 2016, a.
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Just in time for National Trails Day, which is Saturday, June 2, Watson has released the fourth. "Well, for somebody else, a hike might just be walking around a lake — a short cruise like that — or.
AUSTIN (KXAN) — The man who shocked bystanders on the Lady Bird Lake Hike and Bike Trail last month. was charged Tuesday with cruelty to a non-livestock animal. On June 21 at around 5 p.m., two jo.
In winter, the Grüner See, or Green Lake, of Styria, is a small, three-foot-deep body of water surrounded by hiking trails and snow-covered mountains. The best time to dive in the Green Lake is dur.
Salt Lake City Mayor Jackie Biskupski's 2017-18 budget has encountered. The budget is expected to be voted upon June 13. The average residential sewer customer would see an increase of nearly $60 p.
Perri was last heard from June 30 when he texted a photo of himself atop Mount Meeker to a friend. He had been hiking alone, and did not have any. rangers found Perri's car in the parking lot at th.
Köl-Tör lake is set amid supreme mountain terrain in Kyrgyzstan. When to visit: The northeast of both islands is generally.
June 18, 2015 (La Mesa. limit public access to only hiking, picnicking and fishing- -but the lake would no longer be stock.
ELLSWORTH, Maine — A warm wind ruffled the surface of Branch Lake. hiking trails and a hand carry boat launch on the scenic lake. It's a place for hiking, dog walking, wildlife observation, berry p.
The hillsides around the lake are a pristine coastal sage habitat, recognized as one of the largest and last strongholds of the threatened California gnatcatcher. Dogs may participate in the hike but.
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Tag Archives: Haryana Sikhs
HSGMC to oppose INLD-Akali tie-up
Karnal, Haryana: The Haryana Sikh Gurdwara Management Committee (HSGMC, ad hoc) on Monday decided to ask its entire team, including the executive committee, to canvass actively in favour of Congress candidates. After chairing a meeting at Kurukshetra, HSGMC senior vice-president Didar Singh Nalwi told Hindustan Times on the phone that a decision was taken to oppose the Indian National Lok Dal's ...
Newly Formed Haryana Gurdwara Committee To Support Congress in Upcoming Assembly Polls
Chandigarh: The Haryana Sikh Gurdwara Management Committee (HSGMC) ad-hoc panel senior vice-president Didar Singh Nalvi has announced to openly support the Congress party in the upcoming Assembly elections in the state. While speaking with the press, Nalvi said, "The HSGMC has agreed to back the Congress principally in the elections as the party kept its promise of forming a separate gurdwara ...
Gurdwara act a solution to many problems: Chandumajra
Jalandhar, Punjab: Shiromani Akali Dal (SAD) general secretary and Member of Parliament from Anandpur Sahib Prem Singh Chandumajra on Saturday advocated the need to implement the All India Gurdwara act, which proposes single governing body for all gurdwaras across the country and is a long-pending demand of various sections of the Sikh. Addressing a press conference, Chandumajra said there was a ...
Haryana Gurdwara Committee: Five Facts You Need To Know
1) Until the formation of the separate committee for Haryana Gurdwaras, the Akali-dominated SGPC had control over Gurdwaras in Punjab, Haryana, Chandigarh and Himachal Pradesh. 2) SGPC has a total of 190 members, out of which 170 are elected. From the elected members, 157 are from Punjab, 11 from Haryana and one each from Chandigarh and Himachal Pradesh. Haryana Sikhs ...

redpajama_set_name: RedPajamaCommonCrawl


On Sunday, Jan. 27, the second and third floors of the HUB were filled with over a thousand people from around Southern California who were given admittance to the third annual Highlander Convention. Before admission started at 11 a.m. students lined up as far as the beginning of the UC Riverside timeline mural; by afternoon Highlander Gaming (HLG), the organizers of the event, ran out of wrist strap tickets after about 800 attendees had been allowed into the main halls.
The all-day convention was hosted by HLG and sponsored by CORSAIR, MSI, GIGABYTE Technology, NVIDIA, Seasonic, ASPB, Riot Games and Tespa. Throughout the day, panels, tournaments, a game room dedicated to "osu!" — a computer-based rhythm game — an artist alley and many other activities were held on the second and third floors of the HUB.
Throughout the day the big screen at the back of 302 broadcasted esports competitions, such including 1v1 fights in Overwatch and League, as well as Fortnite matches later in the night. On the sides, sponsors CORSAIR, MSI, Seasonic and VIVE set up booths to showcase their latest products. Some booths, like CORSAIR, were allowing visitors to play with "Beat Saber," a rhythm-based game of motion-based inputs, with their Virtual Reality headsets.
Also in HUB 302, a row of monitors were set up for attendees to compete in the convention's "Super Smash Bros. Ultimate" and "Super Smash Bros. Melee" tournaments; the monitors were either as modern as a computer monitor or as old as a fat-back TV from the 90s. Over 200 people signed up for the tournament; anyone that wasn't competing but wanted to play could do so in the Free Play area in HUB 367.
This was James Almaguer, a first-year undeclared student, and Christopher Padilla's, a third-year psychology major, first time attending Highlander Con. Padilla came to support Almaguer and check out the "osu!" room.
Kara Trowbridge, a first-year undeclared student, has been playing smash for 10 years but it was not until this year's Highlander Con that she decided to participate in a tournament. "Honestly, meeting other people who like the same thing as you is really fun," Trowbridge said. Trowbridge's friends came to support her as she competed in the tournament;. their residence hall had actually just held a Smash tournament earlier in January, and Trowbridge found that playing Smash has brought them closer together.
One of the events in the convention was a cosplay competition. The first prize winner received a $100 Michael's gift card; the winner turned out to be Maddy Ganley.
Ganley, a fashion and designing student from Pasadena City College, cosplayed as Brigetta, a character from Overwatch. Ganley heard about the cosplay competition from her boyfriend at UCR,and said that her cosplay was made of EVA foam, acrylic paint and LED lights.The overall cost of her cosplay was around $250 to $300; "it's not a pretty number to look at," Hanley joked.
Highlander Con was planned and staffed by the members of HLG, an organization on campus that not only promotes esports and the gaming industry but also holds conventions like Highlander Con. "(HLG) is more than just a simple 20-person club," said Allen Wang, third-year business major and director of graphics for the group.
Wang spoke to the Highlander about the busiest areas of the convention. "The osu! room was stacked with people who brought their entire desktops and lugged it to the second floor. We think that's an important part of Highlander Con to keep that sentiment of being able to play games together in one big room and have a day for gamers," explained Wang.
The first Highlander Con was meant to be a place for people to bring their own set ups and play. For this year's convention, the sentiment was kept by providing the Free Play room in HUB 367. The first Highlander Con was held in 2017 with 628 people attending and events held in the third floor only. Since then, the convention has grown in size and has expanded into the second floor of the HUB. This year, the convention was meant to be in November, but due to logistics it was moved to January where it was combined with their Build-a-PC event.
HLG plans to hold Highlander Con again next year. For anyone interested in joining HLG, you can find them on Highlander Link (@Highlander Gaming) or on their Discord server (@HLG).


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ISU has cancelled 2021 Europeans, ISU Grand Prix Final, World Junior Synchro; Stockholm Worlds still on for now
Thread starter Sylvia
I don't know, it's not the country, but rather the people who are organizing this. Las Vegas went off well because they had the right people in place to ensure it'll be safe. I'm hoping Sweden will also have the right people in place. We can't assume before it even happens that it'll be a disaster.
You think the ISU isn't going to go above and beyond to make this event happen safely and that the organizers will not do the same? I don't really understand that idea either, as the ISU has another event going on right now and more coming up.
In other words, some of you don't trust anything having to do with Sweden because their cases are high, but you don't want your own countries generalized for the same ideas it seems. In any event, there are surely Swedes who have been following rules since day one, just as Americans and Canadians have. It's not as if they are going to allow the Russians to knock on each hotel room door and breathe on every other athlete..
Reactions: mattiecat13, skaterina, cholla and 2 others
Sweden's cases are not on the rise at all. They are currently on the same decline that is evident in many places around the world. Hopefully it will stay that way, although of course there are never any guarantees. Stop looking at the headlines and start informing yourself. This has been the most irresponsible and often bordering on deliberately misrepresentative coverage of an issue that I personally have observed in my lifetime. I have never seen anything like it and I hope I never do again.
Reactions: skaterina, Dave of the North, Sabine-Yuna and 2 others
mjb52 said:
Also very true - the numbers are shifting downwards. My county has about 2/3 the amount of cases as the entire country of Sweden. I think people got wrapped up in the herd immunity talk, but Sweden's numbers were actually low as hell all summer.
Reactions: Karen-W
anonymoose_au
This has been the most irresponsible and often bordering on deliberately misrepresentative coverage of an issue that I personally have observed in my lifetime.
Seriously? Where do you live that 5,000 cases a day trending down to 3,000 is good news? (ETA: I guess it's good news technically, but that's still a lot of cases) When the Australian state of Victoria reached 700 a day they shut it down, fast. Now there's been relatively small numbers of cases since November when the hard lockdown ended. Christmas time in Aus was a bit of a stuff-up, but things were mostly kept under control, Victoria has just reached 24 days of 0 community transmission.
It's worth noting that the UK was having 700 cases a day at the same time as Victoria. They dilly dallied on taking action and the result is the cluster bomb that nation is in today.
Honestly I was wondering how most of the rest of the world managed to get into such trouble, but the attitudes shown by some certainly explains it.
It just seems really dumb, would a tough lockdown suck? Sure. But once you eliminate or control the spread things are 1000% better. At the Australian Open players and coaches won't have to be on tenterhooks and hoping their masks don't slip and they don't accidentally touch their faces, that's for sure.
Reactions: Lanja, Alilou, Foolhardy Ham Lint and 1 other person
Do you think none of us had a tough lockdown? Seriously? Did Australia even ever have a national lockdown? I feel like you are all completely out of touch with the reality of how the rest of the world has been living for almost a year. From March to May/June almost three billion people were living in virtual police state conditions. Now you have much of Europe back in lockdowns that are worse in many countries than they were then. guess what. It doesn't work when you aren't at the literal back end of the world.
Reactions: Stephanie, Sabine-Yuna and Karen-W
anonymoose_au said:
Seriously? Where do you live that 5,000 cases a day trending down to 3,000 is good news? When our state of Victoria reached 700 a day they shut it down, fast. Now they've had 0 cases of community transmission for 24 days.
It just seems really dumb, would a tough lockdown suck? Sure. But once you eleminate or control the spread things are 1000% better. At the Australian Open players and coaches won't have to be on tenterhooks and hoping their masks stay in that's for sure.
And here we get the holier than thou posts starting all up. Guess what? Your borders were closed, it takes forever to get to where you are from most places, and it's pretty logical that it would easier to contain something on this level. Guess what also happens? People in the US and I'm sure many other countries can't afford to not work, won't get unemployment, and are at risk of losing it all if they didn't stay going to their jobs every day or going back when things reopened. Some don't want to follow rules, but for many this was the reality of the situation. So pat yourself on the back and boast about your own luck.
3000 cases a day is nowhere near the number that some people are trying to push out regarding Sweden. And yes, going down that much that quick is significant when people elsewhere try to make it seem like breathing in the Swedish air will instantly give one CV.
Reactions: Louis, Sabine-Yuna, michalle and 1 other person
Do you think none of us had a tough lockdown? Seriously? Did Australia even ever have a national lockdown? I feel like you are all completely out of touch with the reality of how the rest of the world has been living for almost a year.
No we didn't, but that was because when this thing started our Premiers (the people who run our states) got onto it quickly. Borders were shut, schools closed and assistance given to those who couldn't work.
We might have had a few kooks saying "Oh it's just a flu, settle down, act normal." But luckily not many.
Victoria actually had the longest and toughest lockdown in the world. But they did what they had to do and kept the rest of the country safe.
As far as I can see a lot of the world is, ironically, taking the old Aussie expression of "She'll be right, mate" to heart. People in Europe going on summer holidays, people in the US refusing to wear masks...
My mind boggles that hotel quarantine for returning travellers wasn't a thing in most countries until recently. Now Australia's hotel quarantine system has had its issues, but at least there is one.
But we are indeed isolated down here in Australia so I probably do have it wrong. I just hope the Worlds goes safely and if there are any cases it won't end up in an outbreak or anything.
Reactions: Marco, Foolhardy Ham Lint and skatfan
What the living hell do you think has been happening in other countries? You might want to spend the next few hours reading about the restrictions other people have been living with. You are completely out of touch with reality.
Reactions: Lemonade20 and ccpompom
aka_gerbil
Rooting for the Underdogs
I think our Australian friends just see how they were able to get control of things early and stay on top of it and wish it could have been the same for the rest of us in the world. I can see how mind boggling it is to them to see other countries struggling.
Reactions: Marco, beckab81, Habs and 4 others
aka_gerbil said:
I don't get that sense at all from any of the Australian friends commenting in this particular thread. Instead, I smell a distinct whiff of "if we can't do this then none of you should be able to either."
Reactions: mattiecat13 and Frau Muller
I was thinking the opposite actually... "If we can do it, why can't others"?
I'm just surprised that Sweden had such a laissez faire approach to the Rona. Even when statistics showed that the countries around it (who took tougher precautions) were doing better both economically and case-wise they didn't change tack. So now they're looking at worse economic outcomes and far more dead and sick people. It's like lose-lose.
From a selfish point of view I was/am looking forward to Four Continents been held here, but if the vaccine doesn't work as well as hoped, we'll probably lose it because our Ice Skating Fed certainly can't afford an Aussie Open quarantine situation.
Reactions: Alli84, Lanja, Foolhardy Ham Lint and 2 others
skatfan
It sounds like they really are going to try to have it. I hope it works out. I hope none of the participants gets ********* the way it's happened on other sports.
The new variants spread is the one thing that might change the picture in the next few weeks. Last year's worlds was cancelled because of local health conditions.
For the US athletes and coaches, doesn't the warning about possibly not getting back into the country if health conditions warrant unless they are on "essential travel" apply to them?
Reactions: Lemonade20
Wow... Now you're thinking 2 years out we're still going to be in this? I've seen the comments and speculation that Beijing 2022 won't happen but I'm a loss for words that we've jumped another full year beyond that into potentially cancelling events.
I don't see how going to Sweden for what is effectively your job wouldn't be considered essential.
Reactions: Louis, skaterina, alexikeguchi and 1 other person
MacMadame said:
Us Figure Skating is saying it is leaving it to the athletes to decide whether they will attend Worlds so how can it be essential travel if it's your own choice?
Reactions: Habs
Australia has a track record of the ISU events get moved or canceled. Australia is clearly very cautious about YNW and while we all sure as heck hope this is behind us by 2023, none of us has a crystal ball. I can see why she feels cautious at this point.
I don't understand how repeatedly jumping all over @anonymoose_au is helping.
Reactions: Marco, Erin, beckab81 and 5 others
Well I thought we were getting the 2022 4CCs not the 2023 ones so my mistake. (That's a long time to wait!)
It really does depend on how the vaccines go, I suppose. I wonder when we'll find out since it's too early to know yet.
Reactions: Foolhardy Ham Lint and Karen-W
Well, for someone like Nathan who has endorsement contracts, etc, I think that it would be considered "essential travel" even if the USFS is saying "we're leaving it to the athletes to decide." Someone like @Sylvia who is far more versed on how USFS funding works would be able to tell us whether or not a good/high Worlds placement would impact funding. I don't think it does but in the event that it did, even if the USFS left attendance at Worlds to each skater/team's discretion, I could make an argument that it is "essential travel."
Karen, anyone can make an argument. I was looking for someone with actual information about what "essential travel" is. But thanks for giving us your opinion.
Would the US State Department website have the info? They usually post the travel advisories.
Miezekatze
Everybody with access to a map, should be able to see that they (and New Zealand) are an isolated island in the middle of an ocean.
Besides the density of the population is not at all comparable. For example the biggest city in New Zealand still has a lower population density than my own whole STATE in Germany, which includes all the rural areas and the whole barely populated areas of the Black Forrest.
And I think some people here just have very unrealistic ideas about how borders are between European countries. Before ********* the whole point of borders in Europe was that they only exist on paper.
hotel quarantine for travellers can work with tourists.
But in Germany there's tons of people who cross country borders daily for work or because their life partner lives on the other side of a country border. Obviously they can't quarantine everyday for 2 weeks before starting their work as a nurse in a hospital or care home for the elderly. And you can't seperate people who might have lived in a steady relationship for years by hard borders. So a hotel quarantine only solves a miniscule part of travel.
Reactions: Alilou, Louis, alexikeguchi and 8 others
skategal
Bunny mama
Miezekatze said:
That is a good example of what would get characterized as essential travel.
We have similar in Canada with the USA border and yesterday's restrictions were for non-essential travel only.
I expect that the definition of essential travel in USA will probably be similar also.
skategal said:
Germany has quite some exceptions by now, due to the fact that there are so many borders and so many people who work in another country or have parts of their everyday life tere, like you can travel for work (that includes athletes), visiting your life partner if he lives in another country, visiting close family, taking care of your animal if it lives in another country (there's a significant amount of people here who have their horse living in another country), ... all those things caused people quite a lot of stress in spring 2020 when borders were really strictly closed. Soem people couldn't see their life partner or parents or horse for like 2 or 3 months. I think it's probably hard to understand for some Australians how tight-knit countries are here. Going to another country here might mean you drive 500 meters and shop in a supermarket in France or Switzerland.
Now due to the mutations, Germany made stricter laws that forbid travelling from "mutation countries" to germany for non-essential reasons nearly completely (that's mainly Brazil, South Africa, Portugal, Great Britain and Ireland). There still are going to be exceptions (they might be a bit stricter), but due to basically all non-essential travel to Germany from those countries not being allowed, a lot of flights will get cancelled and it will make it harder to find travel options. AFAIK Sweden did something similar.
Therefor I think stricter travel restrictions due to countries trying to keep the mutations from spreading are the biggest risk for sports events in March, cause no countries here want to take risks before vaccinations take up speed. I think athletes will usually be allowed to travel anyway (obviously they can even travel to Australia with quarantining or Australian Open wouldn't happen), but the hurdles/quarantine risks might become more annoying and more athletes migth decide it's not worth the effort/risk at the moment.
Nonetheless, I think even Australians travel for not all THAT essential business reasons. The German version of "I'm a celebrity, Get me out of Here" is filmed in Germany this year at the moment, but some Australian guy who commentates on it actually did fly from Australia to Germany only this month to take part in it and I read the Australian authories gave him an exception for that.
I find travelling from Sydney, Australia to Cologne, Germany for taking part in a trashy live tv show not all that much more "essential" than travelling for sports. , so I think that high horse some people are sitting on is a bit unwarranted for.
Reactions: Susieqq, michalle, Louis and 7 others
We only have 1 land border here (USA) but the majority of Canadians live within a 1 hour drive of the border.
It plays a huge role in the lives of many Canadians.
I don't think you can find a Canadian that doesn't have a family member living in the USA.
So it's been hard to have it as shut down as it has been since March.
Our air borders are definitely tighter than the land border as the land border needs to allow some essential movement back and forth.
I agree about the athletes.
I can see some athletes who know they are sticking around and competing to 2026 and beyond maybe not wanting to go to Worlds this year.
I expect most of the athletes who are planning to retire post-Beijing will go (P/C excepted.)
It is quite a process to go and compete at Worlds this year. For sure there will be some athletes who think it's not worth the effort.
I could also see Sweden cancelling Worlds at some point if they don't have enough resources to pull it off within the safe guidelines, or if cases blow out again. (I'm once bitten, twice shy after last year! )
It is definitely a lot of effort to do this even without the extra guidelines for crud. But I am glad they are giving it a try.
Did you read what I wrote (the second point)? They have been discussing that idea, because there's really nothing else to go off (besides videos) unless the floodgates are opened for every nation to send an athlete.
Yes. I did. I was emphasizing the silliness of the ISU not expanding the criteria for TES minimums due to a world-wide catastrophic event. I am happy they are seriously considering options.
Reactions: michalle and skatfan
I hope this isn't directed at my post, where I asked a question about a particular USA travel warning. I just wonder how it applies and can see both sides.
IDK. In relation to YKW, I think being Australian these days would be an advantage: A government that looks after its citizens and not sacrificing them for the stock market or economic numbers. But, that is a political discussion.
Reactions: Marco
olympic said:
Doing that doesn't benefit Knierim/Frazier at all as they don't have official ISU scores yet. So there is very little option besides a video review IMO - at least they've figured that out, too.
As there were around 36 entries for men/ladies last year, I think they want to ultimately keep it around that as much as they can rather than open the floodgates by lowering them.
The Challenge Cup in the Netherlands is typically always the last chance for people to hit minimums, and I'm sure it's going to be a huge roster this year of European skaters trying to get an entry for their nation/themselves.
Reactions: sk8nlizard, Karen-W and skatfan
kwanfan1818
RIP D-10
If the ISU is ready to review videos for TES minimums, I don't know why they wouldn't start asap, particularly those skaters who've been names to their teams and as alternates. There's already GP video for a handful of them, and it's not as if they have to care about Nationals, scoring or calling if they use Nationals or Nationals qualifying videos for review. Many also have built-in replay. It can all be done by remote tech panels, overseen by a Tech Committee member via Zoom.
This would narrow down the number of skaters who would need to create a video to meet a minimum standard for consideration.
Reactions: beckab81, skatfan, sk8nlizard and 3 others
Speaking of which, their C0vid19 Measures document (27 pages) makes for interesting reading and is linked from the ISU's event page: https://www.isu.org/figure-skating/...detail/12878/-/challenge-cup?templateParam=11
ETA that I've cross-posted the info & link in the newer thread.
Reactions: Karen-W and taz'smum
Decisions of the ISU Council: Stockholm Worlds (March 22-28) still on; Synchro Worlds cancelled; 2021 Grand Prix schedule/Beijing test event announced
NBC, Peacock, and Multiple Other Networks Have Their 2021-22 Schedules Listed
maureenfarone
Grand Prix Series of Seasons 2022/23 & 2023/24
Aceon6
Provisional allotments for ISU Championships 2022, 2023 & 2024; future bids discussion
2021 ISU World Team Trophy, April 15-18, Osaka, Japan
zigzig


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How can an image recognition company that has been established for less than two years win over a lot of bank clients?
Since CloudWalk's establishment in April 2015, Haitong Securities, Xi'an Bank, China Construction Bank, and many other financial institutions have applied facial recognition system from this company. In Sep 2016, the Agricultural Bank of China (ABC) initially provide the technology to 37 branches, becoming the first commercial bank to use the face recognition technology among the BIG FOUR ( Four main banks in China including Industrial and Commercial Bank of China, Agricultural Bank of China, Bank of China, China Construction Bank). The company we mentioned above is CouldWalk.
Zhou Xi, a Ph.D holder that studies Computer Vision, has become the founder of CloudWalk. In 2011, Dr. Zhou Xi entered the "Chinese Academy of Sciences Hundred Talents Program". Jointly developed with UIUC (University of Illinois at Urbana – Champaign) and the National University of Singapore, he established the Chongqing Institute of Chinese Academy of Sciences. He led a team to develop several intelligent image products such as intelligent image detector,face recognition intelligent personnel management system, large-scale dynamic population characteristics detection system. Also,he is the only representative of the Chinese Academy of Sciences face recognition to participate in strategic pilot A class special "Xinjiang security control".
Nowadays, CloudWalk's competitiveness is proved by years of discipline study and technology, as well as accumulated experience. The team in CloudWalk intend to help more people by focusing on refining technology such as portable large-scale data acquisition arrays, double-layered heterogeneous depth neural networks and so on.
Synced got a chance to interview with Dr. Zhou Xi . from personal experience to CouldWalk 's development, future trend. Here is the interview details.
Synced: Hello,Dr.Zhou! Why did you choose the image as your career?
Zhou Xi: At first I studied voice at the China University of Science and Technology,later went to Beijing, spend a quite lot time in the Microsoft Asia Institute of speech recognition group. However, I made a wrong judgement at that time because I thought Voice has no future, somehow it turns to be a right decision. Comparing with voice field, Image recognition of video and images is a much larger area that can solve the more problems. Also, from the information analysis perspective, voice is a one-dimensional signal, the image is two-dimensional signal, the video is three-dimensional signal. Image can deliver more information than voice. As to the main purpose of voice, we need to distinguish the speech (the voice of people) from voice (Background sounds).
Images and video are completely different. For example, face recognition. We need to identify people's face from the image , as well as his emotions, age, gender. However, Image and video recognition is much more than that. In medical, early cancer and other diseases can be identified by image processing. Through the image recognition and big data analysis, the better part of the suspects can be found and then we could ask professionals to double check. Don't you feel it is a more efficiency way to safe people's life? Also, It can be applied in the industrial vision by detecting the defects samples : is there any crackers ? is the surface flat ? Automatic driving will also be benefit by showing the road condition.
For the image itself, it is meaningful to identify all things in the universe, not just to recognize the person's face. At that time I saw a news, some people installed a camera under the water in the pool, which can automatically identify if swimmers are drowning or not. I feel this is quite interesting.
Synced: Could you talk about your professor Thomas Huang ? What's he like ?
Zhou Xi: He is a master that can provide you relax environment, giving us a great platform and high-level guidance. He is definitely the Top professors in this areas, who can always demonstrate a big vision to his students.
Figure 1: Professor Thomas S. Huang has a foundation contribution in image processing, pattern recognition, and computer vision.
Synced : How can you start the CloudWalk after that ?
Zhou Xi: I feel I am lucky. No matter voice or image, they all branches of artificial intelligence and even machine learning. There are certain disciplines cross, a lot of things are reused. At that time the voice recognition was more advanced than image recognition because it has come to a systematic stage. When I was in the United States, the images were not at this stage. Most researchers in Image field were still focused on one task or individual server, however, in the voice area, Cluster server array became a common use. I developed a cluster server for Image processing right after I was in UIUC, which is far ahead of everyone. There are a lot of good algorithms and ideas in voice field, and I also practice them on the image. That's why I won a lot of championships during 2006 to 2010. After that, I started to thinking how to make this technology "meaningful" and help others in a variety of occasions. We tried the face recognition initially because we believe face is very important among variable objects. At the beginning of 2014, I ahead to trial the "Smile to pay" via mobile platform. However, it was useless because no one really use it. Indeed, which financial institution will take this seriously? At that time, I started to realized the importance of business model. Thus, I started the CloudWalk.
Synced: How can CloudWalk get a lot of bank customers in a short time?
Zhou Xi: I have been trying to make the technology practical for many years. From Academic demo to commercial products, there is a long way to pursue. Actually, some of our designed system has been applied in XinJiang and another regions since 2011. The product is mature, but not to be commercialized yet. I think focusing matters. We concentrated our research area in face recognition still, and as to application perspective, we focus on financial and security only.
Synced: What's the specific characteristics of Banking area ?
Zhou Xi: Not only requires stability, but also requests a very fast response speed. There is a strict principle called " 2 hour, 4 hour and 8 hour" in the financial system. Director of bank will be aware of the issue if the system shut down for 2 hours ; error report is needed if the issue last for 4 hours; it will be a serious accident if it goes to 8 hours, which will impact the reputation of bank for sure, For IT suppliers ourselves, how can we guarantee that we can fix any issues within 2 hours ? That is a big challenge. Even though CouldWalk just established for few years, but we take every business seriously. Now we have service centers in the top 10 main cities, and have our own sales in each province. We promise that we will be there whenever issues happened.
Synced: What's the super-large-scale mobile data acquisition array ? How to use it ?
Zhou Xi: It is actually inspired by the learning of medical. When you make a CT slice for medical use, every degree from the positive white to the negative white need to be photoed because light is lumens. These photo are combined to a table, which can reverse the table to solve the problems, no wrong surgery, no miscarriage of justice. I learnt a lot from medical study. Thinking about the data analysis now. Mining data is easy but structuring data is not. That's why I need to figure out first when I came back from the U.S. Even if the download from the Internet 10 million face, or install the camera in the street to record face, these data are unstructured. For individual face, we need to ask ourselves : What is the light? Where does the light come from? Is there any cover? What is the expression? Is there any blur? It is difficult to come back one by one.
Talking back to the super-large-scale mobile data acquisition array, it took us a while to realize it. we install a camera every 5 degrees, horizontal from negative 30 degrees to 30 degrees, vertically from 0 degrees to 30 degrees . All the cameras are high-speed camera imported from Canada, 7 layers of 13 columns, a total of 91 cameras formed an array.The array structure is detachable. We had done a synchronization unit to ensure that the millisecond trigger synchronization acquisition. Note that we have to keep up with the storage because of the large video size.
The collection of space is dimensioned, and the human face is fixed. Thus you can get light and angle properties with the applied light arrays. We also designed the script to set the expression, block the wig, hat, eyes and so on. However, it is still not enough. The laboratory environment is limited, the array has to be removable if we want to duplicate the test from inside to outside. Since most of the banking business is happened in the lobby area, so we need to collaborate data from lobby; public security may monitor the channel sometimes, we need to collect data in the channel to see what is the specific situation.Why we still need to work hard to make structured data nowadays ?Just as we often say that society is the best school, but we should set up primary school, middle school, university as well. Learning structured knowledge system at school, so that children have their core value and basic judgement when they are confront with a wide range of data and information. Thus, structured data system always comes first, and then we need tons of unstructured data to refine our model.
Synced: Could you explain to Synced's readers about the double-layered heterogeneous depth of the neural network ? How can this technology combine with face recognition ?
Zhou Xi: I will show you an example. Document photos are used in most format occasions because it is more accuracy . However, the scene photo need a complex network to unlock because it is impacted by variable factors such as light, expression, angle.Same person's photos may looks totally different if crossing years, so we can not just simply put two photo together. The appropriate way to do is to form a distribution on both layers and connect them with lines. On the other side, big data can have a feature as long as the data enough to let it learn. People know about the impact of light, block, expression, so we can completely let it learn. you can tell it can save a lot of time in advanced.
Heterogeneous dedicates the difference of structure. For example, if you want to teach a child about "apple", three characters may be enough , such as "round", "above the fruit pedicle", " touch feel" . The next time you show him an apple and asked him "what is this", he may know or may not know. if he doesn't know, you can tell him "This is the apple I told you last time". He may ask "Why the color is different ? " Then you can answer,"Last time it is a green apple, this time is a red apple." Thus he knows there are different colors of apple eventually. Similar methods when we think about deep learning. How many data do you need if you want to train a machine to recognize "apple" ? Usually 1000 or 10,000 apple data for training, and training recognition rate should be 90%.That is to say if there are 10,000 apples, there are 1000 will identify by mistake. If we ask the computer why those 1000 apples is not recognized, the computer will not tell you because of the color difference. The computer will show you the value result is 0.4 based on partial guide or integral , but the default value of the term" apple" is 0.5 or more. How can we improve it ?Finding more data to training it until the recognition rate reach 98%.
In my opinion, this is not artificial intelligence. The communication process with child is called artificial intelligence because he understands my abstract, the concept. Through the color, shape, material and other abstract concepts, he achieves the definition of a new thing. He will use the same conception to answer question if he makes a mistake, then we can correct the knowledge again.We can interact at a very high level, which partial guide and integral is far behind . Thus, In addition to the basic, primary pixel information, the upper concept (concept information) and attribute (attribute information) is must in order to achieve a higher level of interaction.
Synced: Image recognition will involve a lot of computing, how do we improve the response speed?
Zhou Xi: This may involves engineering problems. Face recognition itself has dozens of modules, from the detection, tracking, segmentation, key points, spin positive, to the quality of analysis, light compensation, angle compensation.etc.For any module , we need to conduct different adaptation for each scene. If the application level is based on mobile phase, the vendor will ask the model size below 1M, but the entire face recognition model has more than 100 million parameters on the server side.At the same time, we are also requested quick response. For example, we need to identify a number of key points within 1ms among a lot of people in a video. Why is 1ms? Because there are a lot of modules to run, to meet all the running time together to achieve "real-time" (within 30ms). What's more, accuracy is another critical requirement. People will feel weird even only 1 pixel difference in some beauty APPs.
We always complain that "countless efforts are put on the adaptation " because of dozens of modules, different scenes and variable hardware (different phone models, servers, embedded devices). It is definitely time consumption to adapt a new algorithm on every model again such as Android、iOS、Linux and so on. That's why for a single face recognition R&D team we need more than 200 people.
Synced: I remember in one speech , you mentioned that CouldWalk can solve the question where people come from. Have we been able to track individual development nowadays ?
Zhou Xi: This can not only rely on us. First of all, all the monitor video need to be structured, and face data need to be extracted and saved up. In the future, if you want to get a personal information quickly, you can quickly get a request from the system to all the server side, so that the information will be summarized, including what he did before and who he met with in all his life. I will say the technical method is feasible but the data connection can not be guaranteed.
Synced:What are the iconic events do you think in the development of image recognition?
Zhou Xi : Image recognition used to be very popular.By the end of the 20th century, it turned to be decline. However, until 2001,Paul Viola and Michael Jones caused an extensive attention by publishing Robust Real-Time face detection. All audiences' face were tagged out when they were aimed with camera immediately. This event could change the meaning of image recognition technology because now people want to use it into realistic. The US government took the lead in the application of all the monitor camera, and strengthen the intelligent monitoring, With the merging with deep learning in 2005, it started to be applied in Image recognition from 2009. Until now,it is still outbreak of the stage.
Synced: What China's role in the development of Image recognition ?
Zhou Xi: In terms of image recognition, we are leading internationally, at least not behind the United States. There is a big market in China for sure, either investment or data resource.
Synced: Some people stated that many image recognition today only focus on winning competition, far from solving real situation in our daily life. How do you think ?
Zhou Xi: Winning a competition is meaningless. Our initial goal is to make image recognition really helpful, making a great contribution in bank, public security, airport and so on. We don't need many winners who can only solve assumed questions because there are tons of daily issues waiting for us. Technology is not for showing off, but helping out.


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text:
Why B-Three
Mayor Luke Ravenstahl
America's Most Livable City
MAYOR PUTS MORE POLICE ON THE STREETS
Technology Upgrade Increases Efficiencies, Highlights Public Safety Push
[PITTSBURGH, PA] August 1, 2007 Mayor Luke Ravenstahl announced today an aggressive timetable to fully implement the Automated Police Reporting System (A.P.R.S.) to put more cops on the streets and increase efficiencies in government. Starting today and ending September 1, police officers will be required to submit all police reports via the A.P.R.S. This one–month trial will solidify the software design in preparation for full implementation in the fall.
Said Mayor Ravenstahl, "I am working hard to find creative ways to increase the number of foot patrols in neighborhoods. Mandating the use of A.P.R.S. technology achieves both goals, without costing taxpayer dollars in overtime or new hires."
Until now, officers had to return to the station to write reports. The A.P.R.S. software application enables officers to submit reports from Mobile Data Terminals (MDTs) in their vehicles, saving countless hours of administrative work. "This will allow our officers to spend more time patrolling our neighborhoods and keeping our streets safe," said the Mayor.
The amount of time saved is expected to be exponential, as officers spend approximately 10 percent of their workday filing reports at the police station. Carnegie Mellon University will be conducting a study to analyze time saved with A.P.R.S. Said Chief Nathan Harper, "By decreasing the amount of time police officers expend writing reports, we expand their ability to interact with the public, thereby increasing productivity."
In addition to increasing police visibility, A.P.R.S. technology is saving taxpayer dollars. Last year the Bureau of Police generated over 277,000 police reports, an administrative feat achieved with overtime pay and by hiring a part–time Telephone Reporting Unit to assist with report writing.
With this initiative, Mayor Ravenstahl brings Pittsburgh into the forefront of police technology. Less than 2 percent of cities have this technology, and those that do paid upwards of $1 million to design, implement and upgrade the software. The City developed the A.P.R.S. software in–house by working with a team of specialists, B–Three Solutions, for $150,000. "By opting to do more with less we saved taxpayers more than three quarters of a million dollars," said the Mayor.
Michael Walton, President of B–Three Solutions, stated, "Being a local firm, it's gratifying to see this project have such a positive impact for the residents of Pittsburgh. Building upon our long–term working relationship with the professionals in City Information Systems (CIS), it was a pleasure to work with the City to develop this software. Our teamwork with CIS on this project produced a cost–effective solution and a substantial savings for the taxpayers."
In February 2007, Mayor Ravenstahl and Chief Harper increased the number of MDTs in police vehicles by 40%. Currently, 90% of police vehicles have MDTs; the Mayor hopes to bring it to 100% as older vehicles are replaced.
Note: This is the text of a press release from the City of Pittsburgh. The press release and the photograph came from the City's web site site (www.pittsburgh.pa.us).
Provide Us With Your Contact Information, and We'll Reach Out to You.
555 Davidson Road, Suite #4
© 2019 B-Three Solutions, Inc.


text:
Obec Mladoňovice (starší názvy Bladonowitz, Pladnawitz, Mladonyowicze, Mladionowicz, Mladoniowicze, Mladonowitz, Ladionowitz, Mladoňowice, Ladonowitz, Ladoniowitz, Mladěňovice) se nachází v okrese Třebíč v Kraji Vysočina, přibližně 2 km na východ od Jemnice, prochází jí silnice z Oponešic do Kdousova. Žije zde  obyvatel.

Historie
První písemná zmínka o obci pochází z roku 1319, v tomto roce byly Mladoňovice darovány Janem Lucemburským Janovi z Klingenberku, v roce 1348 pak Karel IV. dal léno na Mladeňovicích a dalších vesnicích Jindřichovi z Waldsee a roku 1423 dostal léno Lipolt I. Krajíř z Krajku. Mladoňovice patřily Krajířům z Krajku (ti ve vsi postavili roku 1560 tvrz, dvůr a mlýn) až do roku 1588, kdy vdova po Václavovi Krajířovi z Krajku prodala Mladoňovice svému dalšímu manželovi Vilémovi z Roupova, ten pak vesnici prodal v roce 1616 Kateřině Říčanské ze Smiřic, v roce 1619 pak ale majitelem byl Zdeněk z Roupova. V roce 1629 byly spojeny s budkovským panstvím.

V roce 1630 však Mladoňovice i Budkov měl vlastnit Kristián Illow, ale hned roku 1634 Roupovští odkoupili panství zpět a až v roce 1666 prodal Vilém z Roupova prodal panství Budkov Matyášovi Berchtoldovi. Až roku 1841 bylo panství prodáno Františkovi Xaverovi Krakovskému z Kolovrat, následně v roce 1853 budkovský statek byl prodán Karlovi Lichtštejnskému. Následně se majitelem dvoru stal hrabě Salm Reiferscheid.

V roce 1795 byla ve vsi založena pobočka kdousovské školy, která byla roku 1887 rozšířena na dvojtřídní samostatnou školu. V roce 1900 byla ve vsi založena záložna, v témže roce byl založen odbor Národní jednoty pro jihozápadní Moravu, v roce 1911 byl založen spolek Omladina a po první světové válce pak byly založeny jednoty Sokola a Orla a Domoviny. Po skončení druhé světové války byla v obci postavena mateřská škola a vybudována kanalizace. V roce 1949 bylo v obci založeno JZD, to pak bylo roku 1975 sloučeno s JZD v Třebelovicích, to pak bylo roku 1992 privatizováno v Zemědělské družstvo Třebelovice.

V roce 2002 získaly Mladoňovice právo používat znak a prapor. V červnu roku 2019 obec oslavila 700 let od první písemné zmínky.

Do roku 1849 patřily Mladoňovice do budkovského panství, od roku 1850 patřily do okresu Dačice, pak od roku 1896 do okresu Moravské Budějovice a od roku 1960 do okresu Třebíč. Mezi lety 1980 a 1990 patřily Mladoňovice pod Třebelovice, následně se obec osamostatnila. Součástí Mladoňovic je osada Dobrá Voda a samota U tří koroptví.

Ocenění
Obec Mladoňovice v roce 2000 obdržela ocenění v soutěži Vesnice Vysočiny, konkrétně získala ocenění modrý diplom, tj. diplom za vzorné vedení obecní knihovny. Obec Mladoňovice v roce 2001 obdržela ocenění v soutěži Vesnice Vysočiny, konkrétně získala ocenění bílá stuha, tj. ocenění za činnost mládeže. Obec Mladoňovice v roce 2002 obdržela ocenění v soutěži Vesnice Vysočiny, konkrétně získala ocenění modrá stuha, tj. ocenění za společenský život. Obec Mladoňovice v roce 2004 obdržela ocenění v soutěži Vesnice Vysočiny, konkrétně získala ocenění hnědý diplom, tj. diplom za vzorné vedení kroniky+modrá stuha, tj. ocenění za společenský život. Obec Mladoňovice v roce 2006 obdržela ocenění v soutěži Vesnice Vysočiny, konkrétně získala ocenění zlatá stuha, tj. vítěz, který postoupil do celostátního kola a obec se stala Vesnicí Vysočiny.

Politika
Od roku 1990 do konce roku 2019 byl starostou Jan Chloupek, od 1. ledna 2020 je starostou jeho syn Jan Chloupek. Bývalý starosta zůstává v obci knihovníkem.

Volby do poslanecké sněmovny

Volby do krajského zastupitelstva

Prezidentské volby
V prvním kole prezidentských voleb v roce 2013 první místo obsadil Miloš Zeman (60 hlasů), druhé místo obsadil Jan Fischer (36 hlasů) a třetí místo obsadil Jiří Dienstbier (32 hlasů). Volební účast byla 63.78 %, tj. 199 ze 312 oprávněných voličů. V druhém kole prezidentských voleb v roce 2013 první místo obsadil Miloš Zeman (116 hlasů) a druhé místo obsadil Karel Schwarzenberg (77 hlasů). Volební účast byla 62.87 %, tj. 193 ze 307 oprávněných voličů.

V prvním kole prezidentských voleb v roce 2018 první místo obsadil Miloš Zeman (71 hlasů), druhé místo obsadil Jiří Drahoš (63 hlasů) a třetí místo obsadil Pavel Fischer (39 hlasů). Volební účast byla 65.43 %, tj. 212 ze 324 oprávněných voličů. V druhém kole prezidentských voleb v roce 2018 první místo obsadil Jiří Drahoš (113 hlasů) a druhé místo obsadil Miloš Zeman (94 hlasů). Volební účast byla 64.89 %, tj. 207 ze 319 oprávněných voličů.

V prvním kole prezidentských voleb v roce 2023 první místo obsadila Danuše Nerudová (65 hlasů), druhé místo obsadil Andrej Babiš (63 hlasů) a třetí místo obsadil Petr Pavel (56 hlasů). Volební účast byla 72.33 %, tj. 217 ze 300 oprávněných voličů. V druhém kole prezidentských voleb v roce 2023 první místo obsadil Petr Pavel (129 hlasů) a druhé místo obsadil Andrej Babiš (84 hlasů). Volební účast byla 70.86 %, tj. 213 ze 302 oprávněných voličů.

Pamětihodnosti
 Archeologická naleziště (Sedliště, U Gotharda a Turecký kopec)
 Pozůstatky středověké tvrze
 Zvonička v osadě Tři Koroptve
 Stará lípa na rozcestí u osady Tři Koroptve
 Pomník padlých v první světové válce v osadě Dobrá Voda
 Pamětní deska Petra Mladoně v Mladoňovicích odhalená roku 1990
 Expozice Petra Mladoně

Osobnosti
 Marie Balíková (* 1933), lékařka
 Antonín Chloupek (1884–?), poslanec
 Lubomír Kabelka (* 1933), novinář
 Josef Nekula (1905–1983), gynekolog
 Petr z Mladoňovic (okolo 1390 – 1451), spisovatel a kazatel

Odkazy

Reference

Související články
 potok Rakovec
 osada Dobrá Voda
 Římskokatolická farnost Kdousov

Externí odkazy

Vesnice v okrese Třebíč
Jemnický mikroregion
Obce v okrese Třebíč
Sídla v Jevišovické pahorkatině

redpajama_set_name: RedPajamaWikipedia


text:
Mr. Bender must have been pressured
Feb 11, 2019 Letters 0
The February 9, 2019 edition of the Guyana Chronicle details comments of the Deputy Chairman of the National Procurement and Tender Administration Board, (NPTAB), Mark Bender, in an article headlined 'Hike in tendering thresholds legit'.
Editor, I wish to proffer the view that Mr. Bender was either under pressure to publicly justify the illegal increase in the threshold for spending of taxpayers' monies via restricted tendering or he is complicit in the wrong doings.
First, insisting that Section 61 of the Procurement Act makes the action legal, Mr. Bender, according to the Guyana Chronicle article, says that other sections of the Act are "irrelevant" to the issue at hand. However, the fact is that the only section of the Procurement Act that deals with specifically with increasing thresholds, as was done by the Finance Minister, is Section 54.
Section 54 of the Procurement Act says, "(1) The Cabinet shall have the right to review all procurements the value of which exceeds fifteen million Guyana dollars. The Cabinet shall conduct its review on the basis of a streamlined tender evaluation report to be adopted by the authority mentioned in section 17 (2). The Cabinet and, upon its establishment, the Public Procurement Commission, shall review annually the Cabinet's threshold for review of procurements, with the objective of increasing that threshold over time so as to promote the goal of progressively phasing out Cabinet involvement and decentralising the procurement process."
The fact that the Public Procurement Commission has been established and is functioning cannot be ignored. Mr. Bender has some explaining to do about this, as well as about the billions of taxpayers' monies that were illegally spent after December 21, 2018 when the Coalition Government fell.
Secondly, the February 9, 2019 edition of the Kaieteur News article under the headline 'PPP had also illegally raised tendering threshold -Cabinet documents indicate' published a Cabinet document dated November 11, 2014 – the date being during the period that Parliament was prorogued by the former PPP/C government.
Two points can be made here, 1) Cabinet was vested with the authority to change the thresholds as requested, according to the Cabinet document Kaieteur News refers to, since there was no Public Procurement Commission in place at the time; and 2) there was a legal Cabinet in place, in spite of the prorogation of Parliament, unlike the situation we have now.
The situation now is one where after the December 21, 2018 vote on the no-confidence motion the APNU+AFC Coalition Government stood resigned. I only have to refer to the ruling of the Chief Justice to substantiate this point.
Chief Justice Roxane George-Wiltshire, in her ruling on January 31, 2019, said clearly, "I therefore find that Cabinet is not required to resign with all convenient speed, as the resignation under Article 106 (6), in my view, takes immediate effect following the defect of the Government in a vote of confidence by a majority of all elected members of the National Assembly.
"In this case, Cabinet must be taken to have resigned with immediate effect from the evening of December 21, 2018, and all functions or duties provided in any law to be performed specifically by Cabinet must have ceased from that time."
Editor, the Guyanese must not be made to suffer through another illegal act. It is time that the APNU+AFC Coalition Government understands that enough is enough. There can be no more wastage of taxpayers' monies.
Ibrahim Bin Jabbar
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The Genetic and Molecular Epidemiology Program of Population Health Research Institute conducts the most cutting-edge genetic techniques to assess whether the promise of personalized medicine can be realized. The team explores the genetic risk of stroke, diabetes, obesity, and the response to some of the most widely prescribed drugs for these diseases. The program is led by Dr. Guillaume Paré, Director – Genetic and Molecular Epidemiology Laboratory at PHRI.
Cardio-metabolic diseases such as heart attack, stroke and diabetes are leading causes of death in Canada. Our project aims to identify new blood biomarkers of cardio-metabolic diseases that directly contribute to disease risk. We will do so by integrating information from a comprehensive blood biomarker screen with genetic markers. This will enable us to determine if biomarkers are part of the mechanisms of disease, or merely bystanders. This distinction is important as blood biomarkers that directly or indirectly contribute to disease are more likely to provide unbiased estimates of disease risk and help tailor therapeutic strategies to match individual risk profiles. These blood biomarkers will be used to identify at-risk individuals and help develop new therapeutic interventions.
In many individuals who develop stroke, particularly young people, risk factors such as high blood pressure, diabetes, smoking and abnormal heart rhythm are not at play, so stroke is thought to develop through genetic factors as well as one or more known risk factors. In fact, stroke occurs commonly in some families; better understanding the genetic basis of stroke will help provide answers to important clinical questions.
Increased fats and cholesterol in the blood, which can lead to narrowing and blockage of the blood vessels to the heart, are carried in packages called lipoproteins; one type, called lipoprotein(a) [Lp(a)], is associated with increased risk of heart and blood vessel disease. People of differing genetic ancestry have varying amount and sizes of Lp(a) which makes it difficult to measure in the blood. Smaller size Lp(a) packages lead to larger number of the Lp(a) packages in the blood. Genetic analysis of a large number of people from many different ethnic groups will help us fully understand Lp(a) and its value in helping predict the risk of developing heart and blood vessel disease.
Broadly categorized as antiplatelet and anticoagulation agents, antithrombotic drugs prevent and treat venous thromboembolism, acute coronary syndromes and stroke. Not all patients benefit equally from drug treatment, with some individuals showing evidence of aspirin resistance while others carry genetic variants that modify the platelet inhibitory effect of clopidogrel. Likewise, wide variations in the level of active drug have been noted with the anticoagulation agents dabigatran and apixaban. Such variations result in underdosing some patients (i.e. thrombotic events) and overdosing others (i.e. bleeding events). PHRI aims to identify the pharmacogenetic determinants of key antithrombotic drugs and evaluate their clinical relevance.
Finding gene-gene and gene-environment interactions is a major challenge in genetic epidemiology, yet genetic interactions are thought to be critically important to the genetic architecture of complex traits. Dr. Pare's research developed a statistical method to identify gene-gene and gene-environment interactions, and a novel approach to test regional genetic associations, which was extended to estimate polygenic regional variance from summary association statistics. Such studies laid the foundation for the use of machine-learning methods in determining polygenic risk scores. The use of Mendelian randomization (MR) was pioneered to show that diabetes is causally involved in coronary heart disease, that bile acid sequestrants reduce the risk of heart disease, and used MR to show that HER2 is a causal mediator of the protective effect of ACE inhibitors on kidney function.
Effects of CYP2C19 Genotype on Outcomes of Clopidogrel Treatment.
Effect of PON1 Q192R genetic polymorphism on clopidogrel efficacy and cardiovascular events in the Clopidogrel in the Unstable Angina to Prevent Recurrent Events trial and the Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of Vascular Events.
Association of Cyclooxygenase-2 genetic variant with cardiovascular disease.
Telomere length and risk of myocardial infarction in a multi-ethnic population: the INTERHEART study.


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Selecta Biosciences Presents New Data at 2019 American College of Rheumatology Annual Meeting from Phase 2 Study of SEL-212 for the Treatment of Patients with Chronic Refractory Gout
– Data demonstrate SEL-212 efficacy, reduction in the incidence of gout flares and support for dose selection in the ongoing head-to-head COMPARE trial and in future
Phase 3 clinical studies –
– Enrollment in the COMPARE trial expected to complete by the end of 2019; interim data to be reported in Q1 2020, and top-line statistical superiority data expected by mid-2020 –
WATERTOWN, Mass., Nov. 11, 2019 (GLOBE NEWSWIRE) -- Selecta Biosciences, Inc. (NASDAQ: SELB), a clinical-stage biotechnology company focused on unlocking the full potential of biologic therapies based on its immune tolerance platform technology, ImmTOR™, today announced new data from their Phase 2 dose-ranging study evaluating SEL-212, a combined therapy of ImmTOR + pegadricase for the treatment of chronic refractory gout. Results reinforce that, in the five monthly combination cohorts, SEL-212 is effective in reducing incidence of gout flares and supports dose selection in the head-to-head COMPARE clinical trial and in future Phase 3 studies. These data are being presented at the 2019 American College of Rheumatology (ACR) Annual Meeting in Atlanta, GA.
"The results presented today build on previous evidence demonstrating that SEL-212 could potentially change the treatment paradigm for patients with chronic refractory gout. The data show reduction in flares and a decrease of anti-drug antibody levels, leading to sustained lower serum uric acid levels in patients treated monthly with SEL-212 over five months", said Carsten Brunn, PhD, President and CEO of Selecta Biosciences. "We are extremely excited to share these data, as they provide important context for the upcoming interim readout of the head-to-head COMPARE trial in Q1 2020, and the top-line statistical superiority data in the middle of 2020."
Data from the abstract entitled "Monthly Dosing of ImmTOR Tolerogenic Nanoparticles Combined with Pegylated Uricase (Pegadricase) Enables Sustained Reduction of Acute Gout Flares in Symptomatic Gout Patients" showed that monthly dosing of SEL-212 enables sustained reduction of acute gout flares. In month one, 50% of patients who received pegadricase alone had flares, compared to 35% receiving SEL-212. Further, zero patients receiving SEL-212 had initial flares after the second month of treatment.
The abstract entitled "Phase 2 Dose-Ranging Study of SEL-212 in Symptomatic Gout Patients: Selection of Doses for Further Clinical Development" evaluated symptomatic gout patients treated with pegadricase at 0.2 or 0.4 mg/kg alone or combined with 0.05 to 0.15 mg/kg ImmTOR. Results showed that when administered alone at either dose, pegadricase resulted in a rapid reduction in sUA, which was not sustained due to anti-drug antibodies (ADA) formation in 5 of 6 patients. The addition of ImmTOR at ≥0.1 mg/kg reduced ADA formation, allowing sustained reduction in sUA, but these responses were attenuated when ImmTOR was removed during cycles 4 and 5. The combination of pegadricase (0.2 mg/kg) and ImmTOR (0.1 or 0.15 mg/kg) was given during all 5 cycles in 3 additional cohorts. In these cohorts, 66% of evaluable patients (21/32) maintained sUA levels below 6 mg/dL at Week 20 after 5 monthly doses of SEL-212, and 100% of patients who had sUA <6 mg/dL at 12 weeks, maintained control through 20 weeks. Sustained reduction of sUA levels correlated with low or no ADAs. The percentage of patients experiencing flares in these three cohorts declined from 35% during month 1 to 9%-10% during months 3, 4, and 5. These data led to the selection of a combination of pegadricase (0.2 mg/kg) and ImmTOR (0.15 mg/kg) in the head-to-head COMPARE study of SEL-212 and pegloticase, a pegylated uricase currently FDA approved for use in patients with treatment-refractory gout.
In an abstract entitled "Monthly Dosing of ImmTOR Tolerogenic Nanoparticles Combined with Pegylated Uricase (Pegadricase) Mitigates Formation of Anti-Drug Antibodies Resulting in Sustained Uricase Activity in Symptomatic Gout Patients" subjects were infused with SEL-212 in 28-day cycles, up to 5 times. Safety, tolerability, sUA, ADAs, and uricase activity were monitored, and data demonstrated that patients taking SEL-212 had titers <1080, uricase activity AUCs sustained over 5 treatment periods, and low sUA. These results conclude that when anti-uricase titers are less than 1080, patients showed sustained uricase activity, enabling 28-day treatment intervals and further supporting the once-monthly dosing regimen for SEL-212. Further, results showed that SEL-212 was generally well tolerated at clinically active doses following repeated administrations in the trial.
SEL-212 is a novel combination product candidate designed to sustain control of sUA in patients with chronic refractory gout, potentially reducing harmful tissue urate deposits which, when left untreated, can lead to debilitating gout flares and joint deformity. SEL-212 consists of pegadricase, the company's proprietary pegylated uricase, co-administered with ImmTOR, designed to mitigate the formation of anti-drug antibodies (ADAs). ADAs develop due to unwanted immune responses to biologic medicines, rendering these therapies less potent, which remains an issue across multiple therapeutic modalities and disease states including chronic refractory gout.
About Chronic Refractory Gout
Gout is the most common form of inflammatory arthritis with more than 8.3 million patients in the United States having been diagnosed with gout, which is caused by high levels of uric acid in the body that accumulate around the joints and other tissues, and can result in flares that cause intense pain. Approximately 160,000 patients in the United States suffer from chronic refractory gout, a painful and debilitating condition in which patients are not able to get their SUA levels below 6 mg/dL and therefore have several flares per year and can develop nodular masses of uric acid crystals known as tophi. Elevated SUA levels have been associated with diseases of the heart, vascular system, metabolism, kidney and joints.
About Selecta Biosciences, Inc.
Selecta Biosciences, Inc. is a clinical-stage biotechnology company focused on unlocking the full potential of biologic therapies based on its immune tolerance technology (ImmTOR) platform. Selecta plans to combine ImmTOR with a range of biologic therapies for rare and serious diseases that require new treatment options due to high immunogenicity. The company's current proprietary pipeline includes ImmTOR-powered therapeutic enzyme and gene therapy product candidates. SEL-212, the company's lead product candidate, is being developed to treat chronic refractory gout patients and resolve their debilitating symptoms, including flares and gouty arthritis. Selecta's proprietary gene therapy product candidates are in preclinical development for certain rare inborn errors of metabolism and incorporate ImmTOR with the goal of addressing barriers to repeat administration. Selecta is based in Watertown, Massachusetts. For more information, please visit http://selectabio.com.
Any statements in this press release about the future expectations, plans and prospects of Selecta Biosciences, Inc. ("the company"), including without limitation, statements regarding the progress of the clinical development of SEL-212, expectations surrounding the enrollment and design of the Phase 2 head-to-head (COMPARE) clinical trial comparing SEL-212 and Krystexxa, timing of related data readouts and the ability of the COMPARE results to inform the planned Phase 3 clinical trial of SEL-212, the anticipated timing of the planned Phase 3 clinical trial, whether the head-to-head trial with Krystexxa will demonstrate superiority, the unique proprietary technology platform of the company and the unique proprietary platform of its partners, the potential of SEL-212 to fulfill unmet needs in chronic refractory gout patients including sustained SUA reduction, reduced flares, and once monthly dosing, the company's commercial plans, the ability of the company's ImmTOR platform, including SEL-212, to unlock the full potential of biologic therapies, the potential of SEL-212 to treat chronic refractory gout patients and resolve their debilitating symptoms, the potential treatment applications for product candidates utilizing the ImmTOR platform in areas such as enzyme therapy, the company's plan to apply its ImmTOR technology platform to a range of biologics for rare and serious diseases, the potential of the ImmTOR technology platform generally and the company's ability to grow its strategic partnerships, the sufficiency of the company's cash, cash equivalents and short-term investments, and other statements containing the words "anticipate," "believe," "continue," "could," "estimate," "expect," "hypothesize," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "would," and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including, but not limited to, the following: the uncertainties inherent in the initiation, completion and cost of clinical trials including their uncertain outcomes, the availability and timing of data from ongoing and future clinical trials and the results of such trials, whether preliminary results from a particular clinical trial will be predictive of the final results of that trial or whether results of early clinical trials will be indicative of the results of later clinical trials, the unproven approach of the company's ImmTOR technology, potential delays in enrollment of patients, undesirable side effects of the company's product candidates, its reliance on third parties to manufacture its product candidates and to conduct its clinical trials, the company's inability to maintain its existing or future collaborations, licenses or contractual relationships, its inability to protect its proprietary technology and intellectual property, management's ability to perform as expected, potential delays in regulatory approvals, the availability of funding sufficient for its foreseeable and unforeseeable operating expenses and capital expenditure requirements, the company's recurring losses from operations and negative cash flows from operations raise substantial doubt regarding its ability to continue as a going concern, substantial fluctuation in the price of its common stock, and other important factors discussed in the "Risk Factors" section of the company's most recent Quarterly Report on Form 10-Q, and in other filings that the company makes with the Securities and Exchange Commission. In addition, any forward-looking statements included in this press release represent the company's views only as of the date of its publication and should not be relied upon as representing its views as of any subsequent date. The company specifically disclaims any intention to update any forward-looking statements included in this press release.
For Media:
Joshua R. Mansbach
Solebury Trout
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For Investors:
Lee M. Stern
lstern@soleburytrout.com
Source: Selecta Biosciences, Inc.
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Acupuncture is a form of Traditional Chinese Medicine (TCM), one of the oldest systems of medicine dating back 4,000 years. It is the most commonly used system of healing in the world. TCM stems from the belief that what happens to one part of the body affects every other part of the body. Similarly, organs and organ systems are viewed as interconnected structures that work together to keep the body balanced and harmonious.
The goal of traditional East Asian medicine is to create balance in our bodies. Disharmony occurs when any aspect of our being is over-utilized or under-utilized. Stress, disrupted sleep patterns, poor diet and other body-related issues point to the sources of what is referred to as "a person's pattern of disharmony."
TCM acknowledges that true healing is a multidimensional process. Whereby the body, mind, spirit and emotions must all be unified in the healing journey. The mind and the emotions play a dominant role in creating wellness (or illness) and attracting disease. The theory of acupuncture is based on Qi (pronounced chee), the vital force or life energy of the human body. Qi is believed to regulate balance in the body. TCM asserts there are as many as 2,000 acupuncture points on the human body, which are connected by 20 pathways (12 main, 8 secondary) called meridians, and that these meridians conduct Qi. If there is an interruption, blockage or imbalance in the flow of Qi in the meridians, it causes pain and illness; conversely, correcting this flow restores the body to balance. Various factors affect the smooth flow of Qi, such as injury, poor nutrition and improper diet, organ malfunction or infection by harmful microorganisms. Other factors that disturb the balanced flow of Qi are extreme climatic conditions (cold, wind, heat), as well as the emotional state (pleasure, dejection, stress) of an individual. Through the normal flow of Qi, acupuncture restores balance and health to mind and body.
Cupping is also a treatment that is part of TCM. Cupping is one of the best deep-tissue myofascial therapies available. It is thought to affect tissues up to four inches deep from the external skin. Toxins can be released, blockages can be cleared, and veins and arteries can be refreshed. The suction in the cups causes the skin and superficial muscle layer to be lightly drawn into the cup. This releases fascia and enhances tissue healing. Cupping is much like the inverse of massage - rather than applying pressure to muscles, it uses gentle pressure to pull them upward. For most patients, this is a particularly relaxing and relieving sensation.


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text: Contributors JEROME TAYLOR is Professor of English and Chairman of the Medieval Area of the Department of English at the University of Wisconsin—Madison. He is co-editor and con tributor to Medieval English Drama: Essays Critical and Contextual (University of Chicago Press, 1972). He has also published books on Chaucer, Hugh of St.-Victor, and twelfth-century European culture. EUGENE STEELE teaches at the University of Benghazi, Libya, where he is a member of the English Department. He is at present writing a book on Carlo Goldoni. DONALD BAKER is Principal Lecturer in English and Drama at the Dorset Institute of Higher Education in England. He has taught in Ghana, Uganda, Cameroun, Togo, and Ja maica, and has lectured in the United States on Thomas Hardy, pre-school dramatics, and the nature of comedy. He has published widely in such journals as Comparative Drama, Theatre Quarterly, Shakespeare Survey, Texas Quarterly, and Yale/Theatre. PETER BEEN is Professor of English at Dartmouth College. He has written on Kazantzakis, Cavafy, and Ritsos, and has translated several works by Kazantzakis as well as, most recently, Stratis Myrivilis' novel Life in the Tomb. He is currently working on a large study of Kazantsakis' work in relation to Greek and European politics. ...