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Steven Schlozman M.D.
The Oddly Poweful Role of Cliches During These Fraught Times
In times of stress, a well-placed cliche can go pretty far.
I currently find myself surprisingly drawn to the comfort afforded by well-worn clichés:
I must take things a day at a time.
Tomorrow is another day.
The grass is always greener.
Time flies.
There are all sorts of ways I would have lambasted each of these axioms a mere four months ago. Four months ago, I'd have rousingly argued that a cliché is where you go when your keyboard, and your vocabulary, and, most importantly, your creativity, all conspire to render what you put on the page effectively meaningless.
But that was before 2020 declared itself as a year to beat all years. (Yep, that's another cliché, and as you may have noticed, I am italicizing each cliché that emerges in this piece to help us all to keep track.) Over these last eight months, I have watched the ravages of a global pandemic and the shameful inequities of base racism and corruption. At the end of the day, I now find that this uniquely bizarre and awful time yields clichés that are really not so clichéd after all.
You see, in these extraordinary times, clichés become as ripe as ready fruit. These phrases, overused as they are during ordinary days, become charged and starkly original as we boldly face the tail end of this bizarro year with our eyes wide open.
For kicks, therefore, and because I cannot bring myself to read the news right now, and because my 5 p.m. patient needed to cancel, I thought I'd elucidate the clichés that I am today finding most useful. I invite readers to share with me the clichés that have helped them as we fight this good fight. There must be strength in numbers even if that strength derives from an abundance of trite phrases that speak truth to our seeming lack of power. (That is a bastardized cliché, I suppose...the whole truth to power thing, but credit should go where credit is due—and we have yet another cliché). I shall endeavor as well to use the internet to explicate the origins of each of these phrases. That will perhaps allow insight into the near-magical powers that these old words bring to our table.
Cliché #1: There, but for the Grace of God, go I.
I don't know if it is fair to call this a cliché. Any statement mentioning a deity seems to automatically qualify for something more than a throw-away phrase. When we turn to higher powers because we are challenged to make sense of the fickle behavior of fate, we are treated to a reminder that we are neither deserving nor undeserving of dumb luck.
Like many clichés, the origins of this phrase are not certain, though most sources suggest that a version of it was once uttered by the English theologian John Bradford sometime during the mid 16th century. Upon seeing a criminal being led to the gallows, Bradford is said to have uttered "There, but for the Grace of God, goes John Bradford." The statement finds a close match as well in a much earlier document — Corinthians, 15:8-10 finishes with the humble recognition that "But by the grace of God I am what I am."
Personally, I find this phrase immensely useful as I ponder the relative health and safety of my family, forcing myself to reckon with the fact that it is at most beyond my understanding and at least a function of dumb luck that I was born into a skin pigment and a socioeconomic status that statistically allows me to less painfully weather the current storm of this frightening pandemic. This cliché prevents me from taking too much credit for the fact that I can still pay my bills and put a roof over my head, but reminds me as well, even in the absence of any organized theological ideas that I might or might not possess, that I do in fact play a very real role in at least some of what happens to those who are dear to me. If I were more recognizably religious, I would argue that God's grace allows me the wisdom to listen to the scientists and to avoid the pettiness that is more likely to bring harm than reliable solace.
Cliché #2: Trust in God, but learn to swim.
Wow. Maybe I am more spiritual or at least more agnostically inclined than I had at first imagined. Still, this is a kind of a social foxhole in which we are all taking cover, and it has been said that there are no atheists in foxholes.
As far as I am concerned, the origin of the sentiment comes from my Uncle Morrie. He was a towering 5'2", had a smile that could on its own disarm the most stringent of anger, and although, and even perhaps because he was a devout man, he was also a pragmatist. "Trust in God, Steven," he would say. "But learn to swim." Nevertheless, I must do my due diligence and tell you that before my Uncle Morrie said this, it seems to have first been uttered as a Russian proverb that translates roughly as "Pray to God but row to shore."
Either way, via Russia or via Uncle Morrie, the sentiment reminds me to own my actions as having rewards and consequences. I suppose I shouldn't have to remind myself of this, but things can get awfully busy these days. I'll be actively taking the time to support my choice for President. I intend, in addition, to engage as much as possible in open-minded discussions that I hope will unflinchingly but fairly view the emperor in his most naked state despite the abiding belief by some that he remains adorned and gilded. (yeah, that's a paraphrased cliché. Count it.)
Cliché #3: It is what it is.
Here's one that our President and our former First Lady have seen fit to utilize in the last few weeks. But it is worth pointing out that each used this phrase with what at least to me seems to be a vastly different sense of the power contained in those five simple words.
Let's start by tracing the origin of the phrase. Multiple sources suggest that it was first used by columnist J. E. Lawrence in a 1949 article in the Nebraska State Journal. Mr. Lawrence was describing the hard-scrabble world of the midwestern frontier and wrote that the difficult environment had not an ounce of "sham or hypocrisy." "It is what it is," he wrote of that untamed land.
Fascinatingly, the phrase has wandered through multiple iterations of meaning in its relatively short lifespan. Some have argued that it is especially useful in sports. A referee makes a bad call, but "it is what it is." The ref is the ref. Deal with it. (Another version of the same cliché). This parsing suggests that the phrase is meant to lay blame outside the locus of one's control, even if one must deal with the consequences.
Of course, saying "it is what it is" does not absolve one of prior responsibility, especially if corrective action remains possible once the damage is done. The President has to some extent reversed course from an earlier less-than-blasé approach to the pandemic, but he has yet to acknowledge that he holds some responsibility for our inadequate national response to the current crisis.
That brings me to the other meaning that is often attributed to this particular cliché. "It is what it is" has also been used as a means of saying that it is time to get to work to make things better. To the extent that making things better involves the acknowledgment of past missteps in order to regain confidence and to learn from our mistakes, I find this phrase powerfully resilient when it is deployed with authenticity and optimism. Dispassionately, enthusiastically, and with humble curiosity, we must carefully exam what "it is" that comprises the mess that we are in. Only then can we right our ship. (And we have a final cliché to round out this essay.)
Look. I find I can put these clichés to work to empower me to do what I can to make things better. I will strive to remember that I am neither exceptional nor powerless. I will know that there are forces out there—luck, divine providence, perhaps both; who am I to say — but that at the end of the day, the buck stops with all of us. And yes, thank you, Harry Truman, for putting that adult concept on all of our doorsteps. I have no idea if that phrase originated with you or has more distant roots, but I have another patient and must therefore research the etymology another time. Plus, this essay is already too long. (Apologies.)
Stay safe. Do not give up. I'll say it again: We can right the ship. That's what the clichés tell us.
Submitted by Kat on August 21, 2020 - 12:58pm
I enjoyed this article and yes these sayings are comforting. I've heard that these are cliches because most time they're truisms.
Some I like are;
"Got to row your own boat"
"God helps those who helps themselves"
"This won't last forever "
And yes, "it is what it is". To me it means facing reality of a situation.
Reply to Kat
Quote Kat
Submitted by Steven Schlozman M.D. on August 21, 2020 - 11:24pm
I've added these to my satchel. And there's a theme developing here it seems. All of these are about stepping up the plate (another cliche) and doing what you can. Seems we need the sayings to remind us that something can be done about something
Reply to Steven Schlozman M.D.
Quote Steven Schlozman M.D.
Steven Schlozman, M.D., is an associate director of Medical Student Education in Psychiatry for Harvard Medical School.
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You are here: Home / Blog / Blogstream / What Elders Know About Sexual Politics
What Elders Know About Sexual Politics
by, Ronni Bennett, ChangingAging Contributor
Wow. After the sexual politics of last week, is there anything more to say about contraception, abortion, women's right to choose, perceptions of religious liberty and coerced female penetration – not to mention the widespread male anxiety about female sexuality that all this has made apparent?
Yes, indeed. I think we elders need to remind others what is at stake.
Although some (definitely not all) fundamentalist women go along, it is mostly men taking part in this argument about control of women's vaginas.
Not to overdo since it has been published in about ten million places by now, let's start with the photo of all those men and no women testifying at a Congressional hearing about insurance coverage of birth control last week:
At the risk of overdoing it twice in one day, let's also take one more look at the statement on the subject of contraception from one of presidential candidate Rick Santorum's largest contributors:
After this video went viral (in about six seconds), Santorum tried to disavow his connection to Foster Friess but that's an embarrassingly disingenuous move from a man whose super-PAC accepted $331,000 from Mr. Friess in 2011 and who has famously said elsewhere, "I think [contraception is] harmful to women; I think it's harmful to society."
Women of all political and religious stripes responded swiftly and loudly against the troglodytes who would move the nation into Handmaid's Tale territory. But it's about a lot more than just who pays for birth control.
With the many local attacks on women's health throughout the nation, it is going to be a battle just to maintain what we've already won and thought had long been settled.
Now, you might think that a blog by, for and about elders – which includes, of course, post-menopausal women – would not have a dog in this fight. If so, you would be monumentally wrong.
We elders are the first generation to benefit from reliable birth control and legal abortion. Now, decades later, we are the only ones alive who can testify to what life was like before: a zillion unwanted babies, lethal backstreet abortions and not much chance for college or careers beyond motherhood. (Remember the jokes about MRS degrees?)
If we do not prevail over right wing fundamentalists who would keep women barefoot and pregnant (I had thought that phrase was buried forever), we will be the last generation to control our own reproduction.
All the sexual antagonism last week comes on the heels of a frightening number of state initiatives to limit women's health access. Just a few:
• Already on Kansas, there are only three abortion providers. Now, recent proposed legislation would, among other restrictions, require women seeking an abortion to undergo a sonogram and also require doctors to tell women of a long discredited link between abortion and breast cancer.
Most unbelievably, the bill would exempt doctors from malpractice suits, according to Alternet, if they
"…withhold information from patients that might lead those patients to seek an abortion. In other words, a physician could choose not to tell a woman something important about her own health if the doctor thought the woman might seek an abortion because of that information."
• The Virginia legislature has passed the now infamous vagina bill that will require women seeking an abortion in the first 12 weeks of pregnancy to undergo a transvaginal ultrasound procedure – that is, coerced and medically unnecessary vaginal penetration.
• Oklahoma appears to be on the verge of passing a personhood bill. According to Reuters [emphasis added],
"The Republican-controlled state Senate voted 34-8 to pass the 'Personhood Act' which defines the word person under state law to include unborn children from the moment of conception.
"The measure now goes to the state House where pro-life Republicans outnumber Democrats by more than a 2-1 margin."
• And in Iowa, proposed legislation outlaws abortion entirely:
"The bill, House File 2298, introduced by Rep. Kim Pearson, R-Pleasant Hill, is an outright ban on abortion, and includes criminal penalties of up to life in prison for those who perform abortions."
(An Alternet story by Sarah Seltzer and Lauren Kelley is a good overview of the most outrageous local initiatives to limit women's reproductive rights.)
This all looks to me like a coordinated attack on women by, mostly, men but also the women who blindly follow them, and their success is not impossible. Don't forget that the defeat of the Equal Rights Amendment was due largely to a woman, Phyllis Schafly, and her Eagle Forum.
My sense is, however, that women are not going to allow anyone to undermine the reproductive rights we have. As has been pointed out in relation to the Catholic bishops' objection to President Barack Obama's quite reasonable compromise on insurance coverage for contraception, 98 percent of Roman Catholic women in the U.S. have used birth control at one time or another along with 99 percent of women overall.
However, as the inroads against abortion in individual states indicate, we cannot be complacent nor think other women will handle this for us. We must all speak up and speak out again and again until this is over.
Oh, and one more thing: unless you want these attacks to continue through at least 2016, pray, light candles or whatever it is you do to summon the gods that Rick Santorum is the Republican nominee; I don't believe anyone this sanctimonious can be elected:
"The whole sexual libertine idea; many in the Christian faith have said, well, that's OK, contraception is OK. It's not OK, because it's a license to do things in a sexual realm that is counter to how things are supposed to be."
At The Elder Storytelling Place today, Ellen Younkins: Happy Valentine's Day
Tags: ChangingAging politics sex
Published to: Blogstream, ChangingAging on February 21, 2012
About Ronni Bennett

redpajama_set_name: RedPajamaCommonCrawl


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AN INTERVIEW BY ATHANASÍA AARNIOSUO
The Breakfast Club: Tiina Raitanen on Render
On August 31st, some twenty artists and art professionals gathered at the office of Frame (Frame Contemporary Art Finland), first thing in the morning, to discuss the work of HIAP alumna Tiina Raitanen. These morning coffees, organised by HIAP and Frame, focus on one work by one artist at a time, and they offer a platform for casual, friendly conversation. Introducing the work of Tiina Raitanen and especially her piece titled Render, was curator Hanna Ohtonen. Together the two discussed the piece thoroughly, projecting images and offering ideas for further consideration.
Tiina's installation piece Render (15. – 23.6.2016, Third Space) consisted of three concrete and jesmonite sculptures, painted table and chair legs, rubber bands and plywood plinths. The sculptures were created by combining rubbish and other found objects into one unrecognisable form, that was then cast into either concrete or jesmonite. The rubber bands and plinths are also mostly found or recycled. All these elements combined create an installation that gives a new life and a new purpose to discarded objects.
The installation and the sculptures that comprise it are still. However, there seem to be hints of active movement in the way that the objects have been installed. The rubber bands appear to be pulling the sculptures upwards, and the table legs appear almost mobile. There is also a contrast within the materials themselves. The materials used are mostly plastic. The forms are cast in concrete and jesmonite, which are both construction materials, manmade. Yet the forms that Tiina creates are almost organic in their smoothness.
While Tiina's installations have no narrative structure within them, they still present some elements of seriality and repetition. There are recurrent themes and frequent details in Tiina's work. Her installations are created within specific spaces, taking the quirks of each space into consideration. The installations have no recommended direction in which to read the elements, however they do tend to appear as a segmented whole which requires the viewer to take in the whole in steps.
Tiina is interested in in-between places, such as building sites and landfills. She often walks in such places, looking for details that other people have overlooked. The temporality of those places and the rubbish she finds there make for an interesting subject matter, once turned into sculpture, which is by nature permanent.
There is a great contrast between the temporality of human waste and the permanence of concrete sculpture. Sculpture tends to be viewed as everlasting, and creating an object that is eternal out of something that is momentary, creates a tension. That tension results in what Tiina describes as the fossils of the future; the idea that, upon a time in the future, scientists will be looking at objects from this era as time-capsules, as fossils describing past times, our times.
It is a terrifying idea, that for the first time in the history of the world, humans and human waste are now impacting the earth and its ecosystems permanently. Tiina's sculptures draw attention to that waste, all the plastic and discarded, disposable materials that will soon form an extra layer on the earth's surface. Although the Anthropocene is not something that can now be prevented, Tiina feels that the very least she can do is help give a new purpose to some of that waste.
Some parts of the sculptures were found while on residence in Paris and Wiepersdorf, near Berlin. Tiina believes that residencies are an excellent way to boost one's motivation and creativity, as the rhythm of work changes completely while abroad. The same themes follow, but the mode of working becomes different and more inspired. Of course, the results of the Anthropocene and Tiina's need to work with the subject matter exist as much in Paris as they do in Helsinki.
Tiina is an avid learner. She tries to learn something new for every project that she gets involved with. Usually, this means playing around with new materials, for example jesmonite, the use of which she perfected for Render. However, sometimes it can mean getting involved with a new hobby. While holidaying in Bali, she learned how to surf. The experience was fantastic, yet the contrast between the cleanliness of the waves further out in the ocean, and the dirty shores covered in plastic made Tiina even more certain that her practice is worthwhile.
TA: Tiina, how do you feel sculpture can consider concepts of time and narration?
TR: A sculpture is often interpreted as being very still in time, even though it may have taken a long time to produce. The time spent working on the sculpture is visible in the materials and the technique used in its production. The materials often reflect time themselves. There are materials which are viewed as being trendy, and others, which are considered timeless and eternal, such as bronze or stone. New material innovations are making their way into sculpture.
In my own works, time is also present in the objects that give the sculptures their shape and form. The work process erases old interpretations and creates new meaning, giving my sculptures their own place in a chain of time and memory. I save something, but what and how much? The meaning merges with the rest of the piece and the sculpture transforms.
Also the way in which I position the installation parts in the gallery space creates temporal and narrative layers. The viewer's gaze and their own understanding of the piece create unique narratives between the parts of the installation and between the materials used. I feel that my works are also mysterious; they hold certain narrative elements, yet don't want to reveal too much about themselves.
Read more on Tiina's work: http://tiinaraitanen.net
Render: http://www.th1rdspac3.com/render.html
Third Space: http://www.th1rdspac3.com
Text by Tessa Aarniosuo based on The Breakfast Club (31.8.2016) and an interview (13.9.2016).
Images courtesy of the artist.


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Using the Internet, you can find out whatever that you want to learn about scuba diving without even going into the water. You will find amazing photos available you could look in, to help you get a sense of the kinds of things you will see as soon as you venture out under the water. It is quite remarkable the attractiveness and elaborate scenery that's hidden deep under the water. By the time you've looked at a couple of photos, you will likely be itching to catch some scuba gear and take a look on your own.
It's quite easy to get interested in scuba diving once you start to look at it. Scuba diving is a fantastic chance to become involved with a sport that is both fantastic fun and allows you to be a little bit adventurous. You also get to learn a lot of things about the marine environment. There's nothing else in the world that can give you the exact same experience you get if you're scuba diving, which means you will be glad you gave it a go.
The diving activity is securely provided that you've got the best scuba diving equipment, and you have the proper training to run the equipment. Owning an excellent gear wants a considerable investment. But high-quality gear need not be that costly. Sometimes, the very best scuba diving equipment can be bought at substantially discounted prices. You can expect quality equipment to last for ages. The very best equipment can guarantee your security as well.
Make sure that you are physically fit to take on a scuba diving experience. There are a few medical conditions like recent head injuries, surgery, blood disorders and spinal injuries where being submerged in a pressurized environment is not allowed. Generally, diving requires sufficient physical wellness that will aid in the accomplishment of your underwater adventure. There's nothing you have to feel anxious about in the event that you've been in tip-top shape for as long as you can recall. But remember that simple coughs, fever or colds may greatly affect you when you scuba dive since you will be in a different environment alien to what your body is used to. Clear thinking and superb focus are key components to a smooth dive. It would be somewhat difficult to obtain both when you're feeling somewhat under the weather.
Ordinarily, all scuba divers wear and utilize exactly the identical kind of diving equipment. However, some sailors in colder areas append more gear too. A typical scuba diving equipment package includes pieces such as fins, a mask, gauges, a tank, and a watch and compass. Depending upon how big the water that a wet or dry suit, a hood, and gloves are also worn. The tank kept on the diver's back provides the oxygen to the diver's mask for ingestion when he/she is from the water. Depth and pressure gauges assist the anglers to to get information about their locations and condition.
Possessing the best scuba equipment is a simple and effortless procedure. There are loads of places to go to purchase quality gear. You can buy them from the dive shops, the Internet, or classified ads. Dive stores are the best places where you can test the gear before buying. It's unwise to buy scuba diving equipment that you have not seen.


Mr. Speaker, will the decades-long major national news media cover-up of the brutality - and violence - of abortion methods ever end?
Will Americans ever be told the horrifying details as to how - and how often - abortionists dismember, decapitate, and chemically poison innocent babies?
Will Americans ever be informed by a conscientious, unbiased news media that in the past 40 years, over 55 million child victims have been brutally killed by abortion - a staggering loss of children's lives that equates to the entire population in England? And that many women have been hurt physically, emotionally, psychologically - and according to the Center for Disease Control over 400 women have actually died from legal abortions.
Will Americans ever be told that of the 55 million children, Planned Parenthood alone claims responsibility for destroying over 6 million babies and that just two weeks ago a Planned Parenthood leader in Florida testified at a legislative hearing on a state initiative to protect born alive infants that even when a child survives an abortion, the decision to assist or kill the born alive infant should be "up to the woman, her family and her physician." In other words, even if a child intended to be aborted survives the assault, the choice to kill remains - so called after birth abortion. Isn't that extreme child abuse?
Murdering newborns in the abortion clinic, it seems to me, is indistinguishable from any other child predator wielding a knife or a gun. Why isn't that that child seen as a patient in need of medical care, warmth, nutrition and dare I say - love?
Now another national media cover up! In this case, even when a Jeffrey Dahmer-like murder trial of an abortionist named Kermit Gosnell, who ran the benign-sounding Women's Medical Society, unfolds in a Philadelphia Courtroom replete with shocking testimony of beheadings, unfathomable abuse, death, and body parts in jars. To this day, the national news media remains uninterested, indifferent - AWOL. Why the censorship? Gosnell's "house of horrors" trial fails to attract any serious and meaningful national news reporting.
Dr. Kermit Gosnell is on trial for eight counts of murder. One count is for the death of a woman who died during an abortion at his clinic. Seven counts are for babies who survived their abortion and were born alive but then killed by severing their spinal cords with a pair of scissors.
In the words of the Grand Jury report: "Gosnell had a simple solution for unwanted babies: he killed them. He didn't call it that. He called it 'ensuring fetal demise.' The way he ensured fetal demise was by sticking scissors in the back of the baby's neck and cutting the spinal cord. He called that 'snipping.' Over the years there were hundreds of 'snippings'.
Indeed, the national news media has not only taken a pass and looked the other way, but their stunning indifference has done a grave disservice to Gosnell's victims - the woman killed, other women injured and children slaughtered by Gosnell. Because of the national media's indefensible silence - because of their failure to report - other women and children at other abortion mills might be at risk.
Some media commenters, however, are beginning to take note of the national news media bias and blackout in the case.
"Media Bias: A basketball coach who shoves and curses at his players merits constant coverage by a media also transfixed by Newtown. But a Philadelphia doctor on trial for murdering a woman and seven babies? It's ignored.
" Infant beheadings. Severed baby feet in jars. A child screaming after it was delivered alive during an abortion procedure. Haven't heard about these sickening accusations?
In a letter sent by Media Research Center President Brent Bozell and twenty prominent leaders call on the broadcast networks to stop censoring coverage of the trial, pointing out that as of April 4th, since the trial began ABC, CBS and NBC have given the story zero coverage in their morning and evening news shows.
Again I ask. When will the media blackout stop? Will America ever be told about the brutality of abortion and the violence that is commonplace inside the abortion industry? Or will the media continue to censor this trial of the century, because it exposes an all too inconvenient truth that not only are unborn children destroyed in these killing centers, but that even babies who survive the abortion can't escape the deadly hand of the child predator.
Who is running these news media sources - one person who owns or has extreme control of them all? Are these media sources actually independent? If so, why they are so much in concert together?


text:
Statement From Thriller Live
The producers, cast and creative team on "Thriller – Live" are deeply saddened and shocked at the news that Michael Jackson has passed away overnight in Los Angeles.
"Thriller – Live" was created to celebrate the career of the world's greatest entertainer and undisputed King of Pop and the Jackson 5, and his phenomenal, unparalleled career was the show's inspiration.
We can think of no greater tribute to the memory of the man and his incredible music
than for tonight's performances at the Lyric theatre in the West End and Manchester Opera House go ahead as planned.
The lights outside the Lyric theatre and Manchester Opera House will be dimmed in tribute to his passing at 7.30pm and a minute's silence will be held in the auditorium.
All of the Thriller Live cast, crew and production team send out their love to Michael's family and children.
"Thriller – Live" was conceived and created by Executive Director Adrian Grant, a long time associate of Michael Jackson, and author of 'Michael Jackson – The Visual Documentary'.
He said this morning: "Words cannot express my deep sense of loss and sadness; I am shocked beyond belief that Michael has died. My full condolences go out to his family – his children, parents, brothers and sisters. The Jackson family have lost a son and a father, and the world has lost one of the greatest entertainers of all time, a true legend.
Michael Jackson has been a massive influence in my life – inspiring me to get into the entertainment industry and to produce the best work that I can. I have supported Michael for the past 21 years through my magazines, books and now "Thriller – Live", and I will continue to support and promote his legacy via this musical celebration.
But my main focus right now is very much on Michael Jackson the person. He was warm, genuine, funny and smart, as well as the musical genius we all admired.
Today I have lost a friend, and I will be there for his family, friends and fans. Rest in peace Michael, I love you."
Source: Thriller Live
Britain HAS Got Talent!
Who's Bad
Zac Efron's Michael Jackson Story 3.17 views per day


text:
Q: See what changes will be done to the DB before saving an import in Rails 2.3 I have an import/export from/to xls of my Products, SubProducts & Costs of my DB. The thing is an importation can make big changes on the DB. That's why I need to add one step: the preview of the changes and a confirm link.
I have no idea how I could "simulate" the import, log the differences, NOT save changes yet and wait for the user's confirmation.
Can somebody help me on this?
(Rails 2.3.11, PostGreSQL)

A: You should leverage the dirty attributes:
Simulate your importation and set your object with the new values:
obj.foo
#=> "old_foo"
obj.foo = "new_foo"
# Don't save!
obj.changes
#=> { 'foo' => ["old_foo", "new_foo"] }

To get the changes stored somewhere in memory, consider:

*

*using cache

*adding a row in you table where you'd serialize everything

redpajama_set_name: RedPajamaStackExchange


Aug 31 (Reuters) - Ontario will include some Tesla Inc car owners under its rebate plan as the province winds down an incentive program for electric cars, the ministry of transportation said on Friday.
The decision follows the Ontario Superior Court of Justice on Tuesday striking down a transition program, including the Electric and Hydrogen Vehicle Incentive Program, set up by the new Ontario government, which excluded Tesla customers from qualifying for rebates.
The incentive program provides rebates of up to C$14,000 ($10,640) for people who bought electric cars.
"Ending the Electric and Hydrogen Vehicle Incentive Program could save Ontario taxpayers up to an estimated $1 billion over four years," he said.


text:
package cc.ycn.common;

import cc.ycn.common.bean.WxMsgConfig;
import cc.ycn.common.bean.WxPayConfig;
import cc.ycn.common.util.StringTool;
import cc.ycn.weixin.aes.AesException;
import cc.ycn.weixin.aes.WXBizMsgCrypt;
import com.google.common.base.Joiner;
import org.apache.commons.lang3.builder.ReflectionToStringBuilder;
import org.apache.commons.lang3.builder.StandardToStringStyle;
import org.slf4j.Logger;
import org.slf4j.LoggerFactory;

import java.util.*;

/**
 * 微信签名工具
 *
 * @author andy
 */
public class WeixinSignTool {

    private final static Logger log = LoggerFactory.getLogger(WeixinSignTool.class);
    private final static String LOG_TAG = "[WeixinSignTool]";

    /**
     * 验证推送消息的正确性
     *
     * @return boolean
     */
    public static boolean checkSignature(WxMsgConfig config, String signature, String timeStamp, String nonce) {
        if (config == null)
            return false;

        if (signature == null || signature.isEmpty())
            return false;

        if (timeStamp == null || timeStamp.isEmpty())
            return false;

        if (nonce == null || nonce.isEmpty())
            return false;

        String sign = WeixinSignTool.createSignature(config.getToken(), timeStamp, nonce);

        return signature.equals(sign);
    }

    /**
     * 验证推送的加密消息的正确性
     *
     * @return boolean
     */
    public static boolean checkMsgSignature(WxMsgConfig config, String msgSignature, String timeStamp, String nonce, String msgEncrypt) {
        if (config == null)
            return false;

        if (msgSignature == null || msgSignature.isEmpty())
            return false;

        if (timeStamp == null || timeStamp.isEmpty())
            return false;

        if (nonce == null || nonce.isEmpty())
            return false;

        if (msgEncrypt == null)
            msgEncrypt = "";

        String sign = WeixinSignTool.createSignature(config.getToken(), timeStamp, nonce, msgEncrypt);

        return msgSignature.equals(sign);
    }

    /**
     * 校验Url
     *
     * @param msgSignature   String
     * @param timeStamp      String
     * @param nonce          String
     * @param echoStrEncrypt String 密文echoStr
     * @return String 明文echoStr
     * @throws cc.ycn.common.exception.WxErrorException
     */
    public static String verifyUrl(WxMsgConfig config, String msgSignature, String timeStamp, String nonce, String echoStrEncrypt) {
        if (config == null)
            return null;

        if (msgSignature == null || msgSignature.isEmpty())
            return null;

        if (timeStamp == null || timeStamp.isEmpty())
            return null;

        if (nonce == null || nonce.isEmpty())
            return null;

        if (echoStrEncrypt == null || echoStrEncrypt.isEmpty())
            return null;

        String echoStr = null;
        try {
            WXBizMsgCrypt msgCrypt = new WXBizMsgCrypt(config.getToken(), config.getAesKey(), config.getAppid(), config.getComAppid());
            echoStr = msgCrypt.VerifyURL(msgSignature, timeStamp, nonce, echoStrEncrypt);
        } catch (Exception ignore) {
        }

        return echoStr;
    }

    /**
     * 加密微信消息
     *
     * @param config WxConfig
     * @param text   String
     * @return String
     * @throws AesException
     */
    public static String encrypt(WxMsgConfig config, String text) throws AesException {
        if (config == null || text == null || text.isEmpty())
            return "";
        WXBizMsgCrypt msgCrypt = new WXBizMsgCrypt(config.getToken(), config.getAesKey(), config.getAppid(), config.getComAppid());
        return msgCrypt.encrypt(text);
    }

    /**
     * 解密微信消息
     *
     * @param config WxConfig
     * @param text   String
     * @return String
     * @throws AesException
     */
    public static String decrypt(WxMsgConfig config, String text) throws AesException {
        if (config == null || text == null || text.isEmpty())
            return "";
        WXBizMsgCrypt msgCrypt = new WXBizMsgCrypt(config.getToken(), config.getAesKey(), config.getAppid(), config.getComAppid());
        return msgCrypt.decrypt(text);
    }

    /**
     * 加密微信回复消息
     *
     * @param config   WxConfig
     * @param replyMsg xml-formatted-string
     * @return xml-formatted-string
     * @throws AesException
     */
    public static String encryptMsg(WxMsgConfig config, String replyMsg) throws AesException {
        if (config == null || replyMsg == null || replyMsg.isEmpty())
            return "";
        WXBizMsgCrypt msgCrypt = new WXBizMsgCrypt(config.getToken(), config.getAesKey(), config.getAppid(), config.getComAppid());
        String randomStr = StringTool.getRandomStr(8);
        return msgCrypt.EncryptMsg(replyMsg, "", randomStr);
    }

    /**
     * 计算微信参数SHA1签名
     *
     * @param params String[]
     * @return String
     */
    public static String createSignature(String... params) {
        String packValue = packValue(Arrays.asList(params), "");
        return StringTool.SHA1(packValue);
    }

    /**
     * 计算微信JS参数SHA1签名
     *
     * @param packValue String
     * @return String
     */
    public static String createJSSignature(String packValue) {
        return StringTool.SHA1(packValue);
    }

    /**
     * 计算微信卡券参数SHA1签名
     *
     * @param packValue String
     * @return String
     */
    public static String createCardSignature(String packValue) {
        return StringTool.SHA1(packValue);
    }

    /**
     * 计算微信支付参数MD5签名
     *
     * @param config        WxConfig
     * @param obj           Object
     * @param excludeFields String[]
     * @return String
     */
    public static String createPaySignature(WxMsgConfig config, WxPayConfig payConfig, Object obj, String[] excludeFields) {
        if (config == null || obj == null)
            return "";
        String packVal = packValue(obj, "&", excludeFields) + "&key=" + payConfig.getSecret();
        return StringTool.MD5(packVal).toUpperCase();
    }

    /**
     * 计算微信支付参数MD5签名
     *
     * @param config        WxConfig
     * @param map           Map
     * @param excludeFields String[]
     * @return String
     */
    public static String createPaySignature(WxMsgConfig config, WxPayConfig payConfig, Map<String, String> map, String[] excludeFields) {
        if (config == null || map == null || map.isEmpty())
            return "";
        String packVal = packValue(map, "&", excludeFields) + "&key=" + payConfig.getSecret();
        return StringTool.MD5(packVal).toUpperCase();
    }

    /**
     * 计算微信支付参数MD5签名
     *
     * @param config        WxConfig
     * @param arr           List
     * @param excludeFields String[]
     * @return String
     */
    public static String createPaySignature(WxMsgConfig config, WxPayConfig payConfig, List<String> arr, String[] excludeFields) {
        if (config == null || arr == null || arr.isEmpty())
            return "";
        String packVal = packValue(arr, "&", excludeFields) + "&key=" + payConfig.getSecret();
        return StringTool.MD5(packVal).toUpperCase();
    }

    /**
     * 微信参数打包
     *
     * @param obj Object
     * @param sep String
     * @return String
     */
    public static String packValue(Object obj, String sep) {
        return packValue(obj, sep, null);
    }

    /**
     * 微信参数打包
     *
     * @param obj           Object
     * @param sep           String
     * @param excludeFields String[]
     * @return String
     */
    public static String packValue(Object obj, String sep, String[] excludeFields) {

        if (obj == null)
            return "";

        StandardToStringStyle style = new StandardToStringStyle();
        style.setUseIdentityHashCode(false);
        style.setUseClassName(false);
        style.setUseShortClassName(false);
        style.setUseFieldNames(true);
        style.setContentStart("");
        style.setContentEnd("");
        style.setFieldNameValueSeparator("=");
        style.setFieldSeparator(sep);
        style.setArrayStart("[");
        style.setArrayEnd("]");
        style.setArraySeparator(",");
        style.setNullText("<null>");

        ReflectionToStringBuilder builder = new ReflectionToStringBuilder(obj, style);

        if (excludeFields != null && excludeFields.length > 0)
            builder = builder.setExcludeFieldNames(excludeFields);

        String value = builder.toString();
        String[] parts = value.split(sep);

        List<String> list = new ArrayList<String>();
        for (String part : parts) {
            System.out.println(part);
            if (part == null
                    || part.isEmpty()
                    || part.contains("<null>")
                    || (part.indexOf("=") == (part.length() - 1))) continue;
            list.add(part);
        }

        Collections.sort(list);

        String packVal = Joiner.on(sep).join(list);
        log.info("{} packVal={}", LOG_TAG, packVal);
        return packVal;
    }

    /**
     * 微信参数打包
     *
     * @param map Map
     * @param sep String
     * @return String
     */
    public static String packValue(Map<String, String> map, String sep) {
        return packValue(map, sep, null);
    }

    /**
     * 微信参数打包
     *
     * @param map         Map
     * @param sep         String
     * @param excludeKeys String[]
     * @return String
     */
    public static String packValue(Map<String, String> map, String sep, String[] excludeKeys) {
        if (map == null || map.isEmpty())
            return "";

        Set<String> excludeMap = new HashSet<String>();
        if (excludeKeys != null && excludeKeys.length > 0)
            excludeMap.addAll(Arrays.asList(excludeKeys));

        List<String> list = new ArrayList<String>();
        for (String key : map.keySet()) {
            if (excludeMap.contains(key)) continue;
            String val = map.get(key);
            if (val == null || val.isEmpty()) continue;
            list.add(key + "=" + val);
        }

        Collections.sort(list);

        String packVal = Joiner.on(sep).join(list);
        log.info("{} packVal={}", LOG_TAG, packVal);
        return packVal;
    }

    /**
     * 微信参数打包
     *
     * @param arr List
     * @param sep String
     * @return String
     */
    public static String packValue(List<String> arr, String sep) {
        return packValue(arr, sep, null);
    }

    /**
     * 微信参数打包
     *
     * @param arr      List
     * @param sep      String
     * @param excludes String[]
     * @return String
     */
    public static String packValue(List<String> arr, String sep, String[] excludes) {
        if (arr == null || arr.isEmpty())
            return "";

        Set<String> excludeMap = new HashSet<String>();
        if (excludes != null && excludes.length > 0)
            excludeMap.addAll(Arrays.asList(excludes));

        List<String> list = new ArrayList<String>();
        for (String item : arr) {
            if (item != null && !item.isEmpty()) {
                if (excludeMap.contains(item)) continue;
                list.add(item);
            }
        }

        Collections.sort(list);

        String packVal = Joiner.on(sep).join(list);
        log.info("{} packVal={}", LOG_TAG, packVal);
        return packVal;
    }

}

redpajama_set_name: RedPajamaGithub


1000 G. above ground $3,500.00.
These prices are just the tank. We don't sell any tank unless we fill them. The propane in the tank will be charged at whatever our current rate is. We also deliver and connect the tank at a rate of $ 75.00 per hour plus parts. Prices are subject to change, please contact us to verify current pricing. We also offer underground tanks for sale.


What are the local police departments doing about texting and driving? Are they just ignoring drivers when they see them? I only have a ten-minute commute, but the things I see on that drive are just plain crazy: Moms in mega-sized SUVs with four screaming kids in the back, texting away while they are late getting the kids to school, people stopped in traffic completely dumbfounded by their phone.
I drive a Subaru, low to the ground, so I never know if the SUV in front of me is going slow because of traffic, or they're just being phone stupid. Stoned drivers drive better. Now, I can't say that I've ever seen a texting accident, but I'm sure the statistics hold up indicating its danger. Am I the only one bothered by this? I would really like to see enforcement crack down on this. As Denver is getting more crowded, our highways are jammed, texting becomes a bigger danger each day, and it really pisses me off that some people just don't give a poop.
What's the worst thing you've seen a Denver driver do?


*The preseason rankings from 11/23 were used in this article, as these tournaments occurred before we released the new rankings on 12/11/18.
The Bulldogs won 4 of 5 duals, and were led by Nate Rubino (106), Jakason Burks (120), James Burks (160/170), and Dillyn Miller (195) who posted undefeated records and combined for 13 falls, 1 tech fall, and 1 major decision. Trey Nielsen (145), Deson Stapleton (152/160), and Austin Dougherty (182) only lost one match on the day.
The Spartans finished 2nd highest out of the 12 Nebraska teams who competed in this tournament. Maxx Mayfield (138) blitzed the field earning bonus points in all 8 matches, including 4 falls and 4 major decisions. Brandon Baustert Jr (106) and Grant Lyman both finished 3rd, and combined for 4 falls, 3 tech falls, and 1 major decision. Their lone losses were to the eventual runner-up in their respective weight classes. Nathan Rizek (120) finished 7th and racked up 4 pins, while Chris Karmazin (195) finished 9th and Nic Swift (113) finished 10th.
The Patriots placed the highest out of the 12 Nebraska teams who competed in this tournament. The undefeated Trumble brothers led the way again this week with championship performances. Isaac won the the 182 bracket winning 8 matches and recording 7 falls, while Josh won the 195 bracket winning 6 matches and recording 3 falls and 1 major decision. Antrell Taylor finished 2nd at 132 losing only to Cornell commit and top ranked Phillip Moomey. He also won 2 matches over ranked opponents over the weekend.. Conor Knopick (126) finished 3rd winning 7 of 8 matches with 3 falls and 1 tech fall, losing only to the eventual runner-up. Caleb Coyle (106) finished 5th, Gavin Peitzeier (220) finished 6th and Tyler Antoniak (138) finished 8th to round out the top 10 finishers for the Patriots.
The Discoverers dominated the competition outscoring their 10 opponents by a combined score of 682-58. Seven wrestlers posted undefeated records at the tournament including Blake Cerny (106), Andon Stenger (113), Clay Cerny (120), Carter Kucera (132), Carson Zwingman (182), Anthony DeAnda (195), and Kasten Grape (220). Together, they recorded 50 falls. Finishing with only one loss were Tanner Kobza (126), Avery McMeekin (160) and Eddie Loredo (285).
The Bearcats were the 2nd highest placing Nebraska team thanks to top 10 performances by 9 of their wrestlers. Phillip Moomey (132) led the way with an 8-0 record including 5 falls on his way to a 1st place finish. Fellow senior Nick James (145) finished 2nd as he recorded 5 tech falls and 1 fall over the weekend. Gus Franzen (5th at 170) and Gage Ferguson (6th at 126) were the next highest placers, thenHunter Nagatani (8th at 113), Rylie Steele (8th at 120), Archer Heelan (9th at 106), Gauge McBride (9th at 138) and Carter Abels (9th at 160) rounded out the others placing in the top 10.
Seniors Nolan Niemiec (132) and Creighton Baughman (145) both placed 4th and combined for 5 falls and 4 major decisions. Carson Maas finished 6th at 182, Cole Price finished 10th at 152, and Cody Niemiec (126) won 2 matches by fall before losing 4-3 to the eventual runner-up from Liberty before injury defaulting his next match.
The Islanders received solid performances via seven top 10 finishers. Leading the way, senior Aidan Williams (3rd at 160) recorded 5 falls and only lost to the eventual runner-up, while Daylon Keolavone (4th at 195) recorded 2 falls and won 4 matches. Blake Cushing (6th at 113) avenged an early tournament loss while Ethan McPhillips finished 7th at 285. Juan Pedro (106), Kolby Lucasiewicz (132) and Oscar Richter (182) all finished in 10th place.
The Chieftains won 4 of 5 duals to finish second at their home tournament. The Grice brothers led the way, as both Gabe (106) and Garrett (113) pinned every one of their opponents. Daniel DeRosier (126) Caelan Hester (132) and Collin Mutzenberger (138) each went 4-1 and combined for 7 falls, 1 tech fall, and 1 major decision. Brett Olson (160) and James Larson (170) both went 3-2 on the day.
The Eagles were led by Emilio Haynes (113) and Deon Davis (145) who both won their brackets and scored bonus points in every one of their matches. Jacob Frezell-McClinton finished 2nd at 285, while Ryan Turner finished 3rd at 120. Ka'Ron Davis (182) and Jacob Hilding (195) both finished 4th in their respective brackets.
December 12, 2018 in High School.


text:
U Microfinance Bank celebrates 200th branch network landmark.
Islamabad, October 04, 2019:
U Microfinance Bank inaugurates its 200th Branch situated in Gilgit with the commitment to take banking services to the last mile in Pakistan. The President & CEO of U Microfinance Bank, Mr. Kabeer Naqvi along with the management team inaugurated the branch on 4th of October 2019.
Mr.Naqvi while speaking at the occasion said that "we are committed to expanding our footprint across Pakistan and grow our network to serve the unbanked population of the country. We strongly believe that access to microfinance services helps to build a more inclusive society and our financial services contribute in creating livelihoods for our customers. Our expanding geographical footprint is a testament to our commitment towards economic enablement of the unbanked population of Pakistan".
Mr. Naqvi thanked U Microfinance bank's shareholder and the board for their continuous support and trust. He said that State Bank of Pakistan has played an instrumental part in helping us achieve this landmark by extending unparalleled support and guidance. He further added that U Bank is immensely grateful to its customers for their confidence in U Bank's brand. Lastly, Mr. Naqvi thanked U Bank's employees for their hardwork and passion, who are at the heart of this organization. U Microfinance bank is a wholly owned subsidiary of PTCL and currently operates in over 160 cities and the rural areas. It offers a wide range of microfinance loans and deposit products. U Bank's branchless banking arm – U Paisa, provides banking services at approximately 45,000 agent locations across Pakistan. U Microfinance Bank is undergoing a digital transformation and is getting ready to serve its customers through digitizing the loan process, provide 24 hour banking services through its own ATMs and offer internet & mobile banking services.


Oriental Poppies provide a cheerful display of huge, satiny flowers in late spring and early summer. Plants form a low clump of coarse, hairy leaves, and usually go dormant, disappearing completely by late summer. This compact-growing strain features flowers in shades of white, pink, salmon and scarlet. Because they disappear in summer, place something beside Oriental Poppies that will get bushy later in the season, such as Rudbeckia, Russian Sage, or fall-flowering grasses. Divide in August to September. Use for cutting just as the buds begin to open.


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Home Featured Sculpture Exorcist and Game of Thrones actor Max von Sydow dies, aged 90
Exorcist and Game of Thrones actor Max von Sydow dies, aged 90
The Swede was a mainstay of nearly a dozen classic, angst-ridden films by Bergman, including Wild Strawberries, Shame and the 1957 release The Seventh Seal, in which he featured in one of Bergman's most memorable scenes, as the medieval knight who plays a game of chess against the grim reaper.
Actress Inga Landgre, 92, who appeared with him in The Seventh Seal, told Sweden's news agency TT that "there was a sense of security in his radiance" adding, "his presence was his strength."
Von Sydow made his Hollywood debut as Jesus in the 1965 film The Greatest Story Ever Told, but gained widespread international fame as the devil-evicting priest in William Friedkin's controversial 1973 film The Exorcist.
Tall and lanky, with sullen blue eyes, a narrow face, pale complexion and a deep and accented speaking voice, von Sydow was often typecast in Hollywood as the sophisticated villain.
"What I as an actor look for is a variety of parts. It is very boring to be stuck in more or less one type of character," he once said in an interview.
Max von Sydow and his wife Catherine Brelet, pictured in 2016. Credit:Invision via AP
In 1980, von Sydow starred as the evil emperor Ming the Merciless in Flash Gordon. He turned down the role as the sinister Dr No in the first James Bond film with the same name, but later appeared as the cat-stroking villain Ernst Blofeld in the 1983 Never Say Never Again, starring Sean Connery as Bond.
He also played a tormented painter in Woody Allen's Hannah and Her Sisters and portrayed the devil in Needful Things, a 1991 horror film based on a novel by Stephen King. In 2015, he appeared briefly in the blockbuster Star Wars: The Force Awakens.
While his characters were often sinister, tormented or evil, the soft-spoken von Sydow said he became an actor to overcome his own shyness.
"I was a very shy boy when I was a kid," he said in an Associated Press interview. "When I started acting in an amateur group in high school, although I wasn't aware of it at the time, I suddenly got a tool in my hand that was wonderful. I was allowed to express all kinds of strange things that I never dared to express before. Now I could do it with the character as a shield, as a defence, and as an excuse.
"I think that for many years I used my profession as some kind of a mental therapy."
Von Sydow was born April 10, 1929, into a family of academics in the southern Swedish city of Lund. He was baptised Carl Adolf von Sydow, but later changed his first name to Max, saying his given name was "not a good name" after World War II.
Although his family was not interested in theatre, he said his father was a master of telling adventure stories that fuelled his imagination as a child. He decided he wanted to be an actor and formed a theatre society with his friends after seeing his first play, William Shakespeare's A Midsummer Night's Dream, at age 14.
He studied at the Royal Dramatic Theatre in Stockholm and acted in small municipality theatres in Sweden for eight years – an experience he later described as crucial for his career.
"I'm very grateful to the schooling I had in Sweden because in order to learn acting you have to work, work, work," he said. "I think I owe very much to those years."
It was during this period he first met Bergman. In addition to The Seventh Seal, he would star in 10 other Bergman films, including The Magician, The Virgin Spring and Wild Strawberries, and develop a close relationship with Sweden's most famous moviemaker.
"I can't say exactly what influence he's had on me, but it must be enormous," he said of Bergman. "We did most of that work when we were much younger. We were free – he hadn't yet become world famous and I was just a regular stage actor with a few film roles to my credit. We worked hard and had a lot of fun."
Von Sydow married Swedish actress Christina Olin in 1951 and had two sons, Clas and Henrik. The couple later divorced and he married French filmmaker Catherine Brelet in 1997, with whom he had two more sons, Yvan and Cedric.
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enQuire Bio » Products » Antibody » Catenin, beta (CTNNB1) Ultraspecific Antibody Tested against >20,000 Human Proteins
Catenin, beta (CTNNB1) Ultraspecific Antibody
Tested against >20,000 Human Proteins
SKU: 1499-MSM11
Tested Applications: IHC
Available Conjugates: Unconjugated
Isotype: Mouse IgG2b, kappa
Mass Spec Validated?: Not MS Validated
1499-MSM11-P0 Size: 20 ug, Tag: Unconjugated $ 199.00
1499-MSM11-P1 Size: 100 ug, Tag: Unconjugated $ 429.00
1499-MSM11-P1ABX Size: 100 ug, Tag: Unconjugated $ 429.00
SKU: 1499-MSM11-P0
Catenin, beta (CTNNB1) General Information
Cadherin associated protein, beta 1 88kDa, Catenin beta-1, CATNB, CHBCAT, CTNNB1
92kDa
Ships on blue ice.
Curated Database and Bioinformatic Data
Gene Symbol 1499
Entrez Gene ID CTNNB1
UniProt ID(s) P35222
UniGene ID(s) Hs476018
COSMIC ID Link(s) CTNNB1
KEGG Gene ID(s) hsa:1499
General Description of Catenin, beta (CTNNB1).
Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
Human Anti-Catenin, beta (CTNNB1) Antibody Product Attributes
Tested Applications: IHC.
Anti-Catenin, beta (CTNNB1) Antibody Clone: CTNNB1/2098
Clone CTNNB1/2098 Host and Isotype: Mouse IgG2b, kappa
Anti-Human Catenin, beta (CTNNB1) Positive Control Sample: HeLa or MCF-7 cells. Breast carcinoma
Cellular Localization of Antibody CTNNB1/2098 Staining: Cell surface and cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide. Also available without BSA & Azide.
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G purified from Bioreactor concentrate.
Immunogen: Recombinant full-length human beta-Catenin (CTNNB1) protein
Storage Conditions: Store at 2 to 8 C (refrigerate). Stable for 24 months when properly stored.
Catenin, beta (CTNNB1) Previously Observed Antibody Staining Patterns
Observed Subcellular, Organelle Specific Staining Data:
Anti-CTNNB1 antibody staining is expected to be primarily localized to the plasma membrane.
Observed Antibody Staining Data By Tissue Type:
Variations in Beta Catenin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in bile duct cells in the liver, cells in the seminiferous ducts in testis, cells in the tubules in kidney, epidermal cells in the skin, exocrine glandular cells in the pancreas, glandular cells in the adrenal gland, appendix, breast, cervix, uterine, colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, parathyroid gland, prostate, rectum, salivary gland, seminal vesicle, small intestine, stomach and thyroid gland, hepatocytes in liver, keratinocytes in skin, myocytes in heart muscle, myoepithelial cells in the breast, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the cervix, uterine, esophagus, oral mucosa, tonsil and vagina, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. More moderate antibody staining intensity was present in bile duct cells in the liver, cells in the seminiferous ducts in testis, cells in the tubules in kidney, epidermal cells in the skin, exocrine glandular cells in the pancreas, glandular cells in the adrenal gland, appendix, breast, cervix, uterine, colon, duodenum, endometrium, epididymis, fallopian tube, gallbladder, parathyroid gland, prostate, rectum, salivary gland, seminal vesicle, small intestine, stomach and thyroid gland, hepatocytes in liver, keratinocytes in skin, myocytes in heart muscle, myoepithelial cells in the breast, respiratory epithelial cells in the bronchus and nasopharynx, squamous epithelial cells in the cervix, uterine, esophagus, oral mucosa, tonsil and vagina, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. Low, but measureable presence of Beta Catenin could be seen in cells in the endometrial stroma in endometrium, cells in the glomeruli in kidney, cells in the molecular layer in cerebellum, endothelial cells in the cerebral cortex, fibroblasts in skin, glial cells in the caudate nucleus, cerebral cortex and hippocampus, hematopoietic cells in the bone marrow, Leydig cells in the testis, neuronal cells in the caudate nucleus, cerebral cortex and hippocampus, ovarian stroma cells in the ovary and Purkinje cells in the cerebellum. We were unable to detect Beta Catenin in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
Observed Antibody Staining Data By Tissue Disease Status:
Tissues from cancer patients, for instance, have their own distinct pattern of Beta Catenin expression as measured by anti-Beta Catenin antibody immunohistochemical staining. The average level of expression by tumor is summarized in the table below. The variability row represents patient to patient variability in IHC staining.
glioma
renal cancer
urothelial cancer
Signal Intensity
+++ ++ +++ +++ +++ + +++ +++ +++ - +++ +++ +++ +++ ++ +++ ++ + +++ +++
CTNNB1 Variability
++ ++ ++ + + +++ ++ ++ ++ + + ++ + + ++ + ++ ++ + ++
Limitations and Warranty
enQuire Bio's product, Catenin, beta (CTNNB1) MonoSpecific Antibody, is available for Research Use Only (RUO-Only). This antibody is guaranteed to work for a period of two years when properly stored.
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This book highlights the multi-faceted nature of corporate social responsibility and the need for greater engagement across academia to help develop the mechanisms needed to encourage socially responsible approaches across the board. The product of a cross-disciplinary collaboration of authors from various academic disciplines, the book reflects the emergent diversity of academics now studying corporate social responsibility (CSR). Accordingly, it includes contributions from economists to social anthropologists, from accountants to philosophers, and from clinical psychologists to social geographers. Together they provide new insights into aspects that challenge, hinder and enable CSR practitioners and corporations with regard to their financial impact and accountability, governance and supply chains. The book is divided into four parts focusing on the practical, sociological, theoretical and environmental aspects of corporate social responsibility.
Stephen Vertigans is Head of School of Applied Social Studies, Robert Gordon University, Aberdeen, UK. His research interests include Corporate Social Responsibility in the energy sector, with particular attention placed upon social impacts in Africa. To this end he has visited numerous African countries to help build capacity and to investigate how CSR approaches can help overcome deep rooted social problems and political tensions. Stephen was instrumental in the introduction of a MSc programme looking at CSR and Energy. He has published widely across a range of fields including Corporate Social Responsibility, African studies and forms of political violence.
Samuel O. Idowu is a Senior Lecturer in Accounting and Corporate Social Responsibility at the London Guildhall Faculty of Business & Law, London Metropolitan University, UK. He researches in the fields of Corporate Social Responsibility (CSR), Corporate Governance, Business Ethics and Accounting and has published in both professional and academic journals since 1989. He is a freeman of the City of London and a Liveryman of the Worshipful Company of Chartered Secretaries and Administrators. Samuel is a Vice President of the Global Corporate Governance Institute. He has led several edited books in CSR and is the Editor-in-Chief of two Springer's reference books – the Encyclopaedia of Corporate Social Responsibility and the Dictionary of Corporate Social Responsibility. He is also a Series Editor for Springer's books on CSR, Sustainability, Ethics and Governance. One of his edited books was ranked 18th in the 2010 Top 40 Sustainability Books by, Cambridge University, Sustainability Leadership Programme. Samuel is a member of the Committee of the Corporate Governance Special Interest Group of the British Academy of Management (BAM). He is on the Editorial Boards of the International Journal of Business Administration, Canada and Amfiteatru Economic Journal, Romania. Samuel has delivered a number of Keynote Speeches at national and international conferences and workshops on CSR and has on two occasions 2008 and 2014 won Emerald's Highly Commended Literati Network Awards for Excellence. To date, Samuel has edited several books in the field of CSR, Sustainability and Governance and has written four forewords to books. Samuel has served as an external examiner to the following UK Universities – Sunderland, Ulster, Anglia Ruskin and Plymouth. He is currently an external examiner at Robert Gordon University, Aberdeen and Teesside University, Middlesbrough and Sheffield Hallam University.


(3BL Media/Justmeans) -- Most people think that concentrating solar thermal (CSP) power plants must be large and expensive. Systems are generally based on very large steam turbines with a high overhead cost that can only be amortized over large scale production rates (typically 50-100MW, or more). This amount of power requires thousands of reflectors spread out over a large area. That means it will most likely be sited in some remote area, far from where the power will be used, thereby subject to significant transmission losses.
Aora Solar has developed a different kind of CSP technology that breaks out of this mold.
It is based on a micro gas turbine with a capacity of 100kW, and a compact heliostat (tracking mirror) field, with the heliostats close to the tower. This field directs intensified sunlight on to the solar receiver which is located at the top of the tower. The operating fluid is compressed air, which is heated to 1000 degrees C, and then expanded through a gas turbine.
It's a hybrid system that can be set to automatically burn biogas or other fuels to heat the air when the sun isn't shining or if the sunlight isn't strong enough. This results in a system that can produce renewable power around the clock, 24 hours a day and can continue to produce power even if the sun doesn't come out for several days in a row.
Rosenzweig considers these systems more nimble than conventional CSP plants, which he refers to as "dinosaurs." Aora's target market is isolated, off-grid villages in developing countries.
The government of Ethiopia recently signed a memorandum of understanding for several plants after visiting Aora's demonstration plant in Almeria, Spain. A typical village there, requires around 68 kW, well within the capacity of Aora's system which seems to be a good fit. Additional units could be added fairly easily.
The compact solar field takes up only about 2,700 square meters, which is about two-thirds an acre. It consists of 45-50 heliostats using parabolic mirrors. These mirrors lose less energy because they are close to the tower. This results in a lower amount of glass per MW, compared to the larger CSP plants.
(3BL Media/Justmeans) – According to legend, in approximately 800 A.D., the energising effects of coffee were first discovered by a goat-herder—or more precisely, by the goats in present day Ethiopia. Coffee is grown in many countries around the world, but its roots can be traced to the ancient coffee forests of Ethiopia.


I am very conflicted here. the reason is - I liked most of the comic. I did, really. And you know why? Because it was fun, contrary to regular King's Batman comics. As a refreshing filler issue, it would be good, if not great. Heck, this is exactly what we should have gotten instead of terrible Preludes to the Wedding leading to even worse #50. But it's too little too late for a bachelorette party when we know it leads nowhere, and most importantly, it unfortunately connects to the Knightmares arc instead of being its own stand-alone thing.
You leaned positive, man. True neutral is 5. That said, fun issue, stand out within this arc in that there's enjoyment to be found in it and despite being filler it's not garbage.
Yeah, it's not fully neutral, because positives seem to outweight negatives - I would like the story if only it was a filler, not a part of Knightmares, I liked the first half's art - overall it was significantly better than issues preceeding it. But then again, it's ruined by being a dream belonging to a terrible story arc.
Yup. Instead, we've got 4 bad prelude comics made just to monetize on he upcoming wedding that ended up not even happening. Nightwing/Hush issue was okay, but the rest was so, so bad. This, or something equally lighthearted would've been so much better.
Still nothing since a non-wedding... 18 issues later and no answers to anything 9 months!!!!! Seriously!!!!! No answers!!!!!
I expect a forced wedding in the end, that won't do any of these characters justice.
It is pure marketing, I extend the league as much as I can, I market a new series (Catwoman) and I play with the answers and a year later I start to release them. I just hope they are convincing.
Yup. This, plus most likely King planning what will be the end goal of his run (Bat and Cat marrying) without actually planning what and how will properly lead to it.
again this plot goes nowhere.
bunch of jumbled conflicting tones thoghout this series.
so inconsistent. no focus. just a mixed up hodgepodge.
Well done sir. In two lines, you summed up the issue quite well. Again, as I wrote in my review, it's tough to hate this issue, but King's tone throughout his run makes it hard to shift dour Batman to funny Batman. I get why he did it, and even think it's a good idea, but you have to lay the groundwork, and King just hasn't.
thank you. and i agree. none of the shifts in tone feel earned or make any sense. this series is just a random mess with absolutely no direction.
Yeah it was quite a mess. On the other hand it shows how lowly Bruce seems to think of Selina& Lois due to how disrespectful they acted towards Superman.
King just keeps trying to ruin these characters. why is editorial ok with this?
This was a fun issue, completely pointless and adds another month of nothing at all happening in this title, but fun. I would even go as far as to say it's worth checking out.
The last assertion is saying a lot because this arc has been some of the worst writing in the title so far. Unfortunately due to its numbering it amounts to nothing but filler. If this were to have taken place before issue #50 it would have been great and a lighthearted addition building up to the much-anticipated nuptials. Regrettably it was not the case.
One of the best results that comes from this issue is that the next is #69. Nice.
It's also the end of this piss-poor arc so that's even Nicer.
The issue is what it is, a funny vision of some events before the non-wedding. If you want more, well, good luck with that. So, from that point of view, the art of Amanda Conner is fine and fits perfectly with the whole point of the issue and the story isn't bad, it's designed to make you laughand and yeah I guess is an ok issue.
At this point I feel the biggest problem with the lastest books is the repetition of the same things. Honestly, I don't know what is real or could be real and what is just a dream or a nightmare or whatever. I say this because I remember King said that some events of the Batman's nightmares are memories which that means we are talking about situations that just real happened, so now, beyond the obvious things, We don't know what is or was real or what is a dream.
Anyway, I enjoyed it in general also I like the final page, but like I said before, We need to push the whole story because it seems like everything just stopped since issue 50 or at least it seems to slow and We all know that the Bat is broken and the Cat is his greatest love and the man is suffering so much. I just hope this arc guides us to something relevant, and I don't mean the Flashpoint Batman, because it is obvious, I mean something else. Each comic book has to work by itself and as part of a great story, maybe in 8, 9, 10, etc., issues we can say, hey, now this or these or all nightmares have sense but even if that happens, one issue needs to work alone and at this moment not all nightmares works alone. I need this arc ends, it's not I don't like it or enjoy it at all but I think there are some important things to tell the readers or maybe King could has explored other aspects about Bruce's psyche in this nightmares. I guess if you have enjoyed the last issues this one is for you if you did't like or enjoy the last ones I think your opinion with this one will be the same.
I wouldn't expect Tom King to pay anything off from this arc. It's just his excuse to pad out his run with some weird stories that don't matter to the ongoing story. Before issue 50, this series had some sort of vision and direction, but since then it's just spinning wheels.
I hope everything returns to normal in the next arc and that there are at least reasonable explanations. I really want "City of Bane" to be a good story.
I really enjoyed that issue. It reminded me the "SUPERFRIENDS" arc which I really liked. Thing is, I just feel like this is meaningless because we already know what happened with the wedding. Honestly, I'm just waiting for this arc to end and it seems like next issue is going to be the last one of this arc.
Art, as usual, was good.
-Hey, I'm just glad these Knightmares are over, to be honest.
-I've never been a fan of Amanda Conner's art, I'll just say it. It's not for me. Never has been.
-Ugh. The dialogue was especially awful this issue. It almost makes me miss the days when this comic had no dialogue whatsoever.
-Why does Tom King constantly feel the need to make every superhero sound like an idiot? Batman and Superman just sound awful here. "Look at this soup. It's… really good."
-I feel like under the pen of a different writer, this might be fun, but it's not.
-I guess this was supposed to be the spiritual sequel to those double date issues. That's too bad. I actually liked those issues.
It is not terrible. Art works very well to this issue. Dynamic between Selina ja Lois is very good. Supes and Bat's -stuff is meh.
But this issue doesn't work because it is not real. It would work so much better, if it was before issue 50. And Bruce wasn't written so workaholic.
Now, the final panel is something that this event has needed for a longest time. Something to show that this is part of something bigger. Sure, we know that Batman is facing his nightmares, but if you didn't read synopsis, every issue has nothing to do with another. I mean nothing. And while that final panel is something that is needed, this issue shouldn't be that.
Meh. This was a waste of my time. I'm so glad that now I know Bruce dreams about Lois and Selina bathing together. That's the type of deconstruction I love. These are such pointless issues that are used to get across the smallest of things. But I forgot that King's name is on it so I gotta appreciate how great it is. Let me try: I hate Tom King's Batman run, but I love to hate Tom King's Batman run. 10/10 tbh.
Wow. Ok, so this was yet another waste of an issue. Even in Batman's subconscious this makes no sense. Stripping Superman robots, endless panels of intergalactic wine, and THE most boring Bruce Wayne ever set to page. The art was nice but was so completely tonely different from the rest of the series that it was off putting Batman who, being the greatest detective, would know Lois and Selina apparently thinks Lois is going to have a robot version of her husband strip for her new friend. Come on man. This issue was so stupid, it was painful. The 4 is just for the art.
Well, that ended the "nightmares" of Batman. As a result, we received a bunch of empty and inconspicuous releases. No. 68 is the worst of them. It does not justify the title of the plot. A naive and empty narrative (several issues are already hidden) only strengthens the negative attitude towards King's work, and the art in this issue is disgusting and can't fit the Batman comic stripes no matter what fake-intellectual idea the author has!
It was a fun issue, very much akin to the Super Friends arc. It will be nice to be over with the Knightmares though.
This would've been better if it wasn't connected to knightmares. The Lana/Selina half is the most solid part, giving a nice respite for the run and giving King the opportunity to focus on someone who isn't a despondent baby. Bruce, If we're taking the events literally, is celebrating his bachelor party with his apparently only friend (no sign of Alfred or the rest of the bat-family) and doing it with the charisma of a potato. This is in contrast with Snyder's Justice League where their relationship always feels warm and sometimes jokey, here we're dragged back down to the depths of knightmares.
Look, man...I'm sorry you never got to do a Catwoman & Lois Lane bachelorette party, but that's entirely your own fault. Cramming it in now is just being a spoiled baby.
Move it along, or walk away.


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Legendary singer who supported The Rolling Stones to perform at Waterford venue
Cormac Neeson will take to the Central Arts, Waterford, stage on May 17
Lead singer of legendary Northern Irish rock band The Answer Cormac Neeson will take to the Central Arts, Waterford, stage on May 17.
Neeson will be performing songs from his first solo album White Feather, an opus that has propelled the rocker into the life-affirming world of country soul and celtic roots music.
Neeson blazed the road to rock n' roll glory for the better part of a decade, touring the world, sharing stage supports with the likes of AC/DC and The Rolling Stones, achieving both fan and peer respect as not only an outstanding vocalist but consummate performer.
All the while, recessed deep within his creative subconscious lay his Dylan destiny, a Celtic knowing that constantly gnawed for release from the straight jacket of rock n' roll. White Feather is that release, the result of three entrepreneurial self-funded writing trips to Nashville.
Through a series of crafted, introspective songs, he delivers a vulnerable, personal and very different sound drawing heavily on his recent experiences. To experience these songs up close and personal in the intimate setting of Central Arts will be a real treat for fans of his music.
"From the creation of these great songs to the cutting of the record, it's been one huge emotional release for me," he says of his new work.
"Like destiny unfolding the way it was always meant to happen."
Tickets for what promises to be a truly unique event are priced at just €15, available from www.centralarts.ie and Ticketmaster. Doors are at 9pm. This is a BYOB event.


With the estimated cost of bringing a drug to market at $2.5 billion and the probability of success of getting to the market from phase 1 at less than 10%, clinical operations have never faced a more challenging environment than now.
While a typical phase 3 trial generates 900,000 data points, many companies still rely on Excel spreadsheets to bring data together from traditionally silo-ed sources. This takes time which limits the ability to drive decisions off clinical data in real time.
Monitoring services predominantly rely on routinely scheduled site visits to verify source data, resulting in high travel costs, and inefficient processes. 100% source data verification accounts for up to 25% of trial costs. However, it does not contribute to data quality value, instead alternative, risk based, approaches can benefit patient safety without such a significant cost contribution.
Reflecting these findings, the ICH GCP guidelines have been revised in 2017, thereby adding a further compliance challenge for clinical operations.
Our global clinical consultants apply their extensive expertise and knowledge to guide sponsors to achieve their strategic objectives through best practices. With over 30 years of experience of supporting Life Sciences companies, breakthrough insights gained through our industry network forums, models for success, and proven structured approaches, Navitas Life Sciences serves as a trusted strategic advisor.
Our breadth and depth of experience has taught us that there is no one-size-fits-all solution. We take a personalized approach to each client situation to ensure results are grounded in industry best-practices, but tailored to specific needs, fit-for-purpose, cost-effective, scalable, and compliant. Engagements begin with a detailed current state assessment to prioritize improvement opportunities and continue beyond pragmatic recommendations to include detailed solution design and implementation. This includes managing the change, developing / revising controlled documents, incorporating revised responsibilities into role descriptions, and developing training plans and materials for roll-out across functional stakeholders.
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