text:
Scottish minimum alcohol pricing may breach EU law
EURACTIV.com with Reuters
Scottish beer brands. [Doug Orleans/Flickr]
Languages: Français
Scotland's plan to introduce a minimum price for alcohol risks breaching European Union law. Edinburgh should explore other ways to protect public health such as increasing tax, a senior adviser to the European Court of Justice said on Thursday (3 September).
Advocate General Yves Bot said in his opinion for court judges that a member state can impose a minimum price, which restricts trade and distorts competition, only if this system was superior to an alternative measure.
Bot said that it was for a Scottish court to examine whether it was better to adopt the alternative, increased taxation, but added it was difficult to justify a minimum price, which appeared less consistent and effective.
>>Read: Lawmakers urge Commission to table new alcohol strategy
Judges of the European Court of Justice, the EU's top court, follow the advocate general's opinion in the majority of cases, but their opinions are not binding. The court's ruling would normally come within three to six months.
The Scottish Parliament proposed in 2012 introducing a minimum retail selling prices for all alcoholic beverages, based on the strength and volume.
The Scotch Whisky Association and two European federations for spirits and for wines challenged the legislation, saying it restricted the trade of drinks between Scotland and EU member states and could distort competition between alcohol producers.
EU law, they said, states that the price of wine should be determined by normal market forces and that excise duties could equally meet the aim of the legislation.
>>Read: Scotland wins court case on minimum pricing of alcohol
That aim is to reduce harm to society and to individual health from excessive or abusive consumption of alcohol. Scottish ministers, who have proposed a minimum price per unit of 50 pence (€0.69), have argued the minimum pricing system would target the relatively cheap alcoholic beverages typically purchased by compulsive or under age drinkers.
According to the Scottish government, the impact of excessive consumption is estimated to cost £3.6 billion per year, equivalent to £900 for every adult in Scotland, who buy on average almost a fifth more alcohol than their English and Welsh counterparts.
Scottish First Minister Nicola Sturgeon said in a statement:
"While we must await the final outcome of this legal process, the Scottish Government remains certain that minimum unit pricing is the right measure for Scotland to reduce the harm that cheap, high-strength alcohol causes our communities. In recent weeks statistics have shown that alcohol related deaths are rising again and that consumption may be rising again after a period of decline. We believe minimum unit pricing would save hundreds of lives in coming years and we will continue to vigorously make the case for this policy."
Paul Skehan, director general of SpiritsEurope, one of the parties to the original case lodged in Scotland, commented:
"We welcome the Advocate General's opinion. The opinion encourages us in our long-held view that MUP is neither proportionate nor necessary, and is, consequently, illegal under EU law. We welcome the statement of this important principle at European Union level since it affects every member state. We await the Court of Justice's final ruling early in 2016. Is it time to now move on? Instead of wasting more time debating the illegality of MUP, we believe it would be far better to discuss useful, legal ways of tackling the alcohol-related issues that persist, not only in Scotland, but around the EU. Tackling alcohol-related harm requires collective efforts for targeted actions - in partnership, at local level. There are a range of other initiatives of proven effectiveness, not based on theoretical computer models. We will continue to work closely with public and private stakeholders in EU countries to reduce alcohol-related harm."
The case of the Minimum Unit Pricing (MUP) in Scotland was referred to the European Court of Justice (ECJ) to ask for its opinion. MUP will not come into force until the legal process is complete. In considering its position, the ECJ asked for written submissions from EU member states, trade bodies and the Scottish government, as well as from the European Commission.
UK and EU trade laws allow in principle for the setting of a minimum price for the retail sale of alcohol for public health purposes by a government or public authority. The Scottish legislation was passed without opposition in May 2012. The MUP was set at 50p per unit. The legislation should have been implemented in April 2013.
On pricing, the regulatory landscape in Europe is currently mixed.
In the EU, member states must apply tax rated for different categories of alcoholic drinks. However, there is nothing in EU rules prohibiting countries from setting minimum prices for alcohol, as long as these prices are compatible with EU rules, such as no discrimination between imported goods and domestic goods, and no restriction on the free movement of goods.
>> Read our LinksDossier: Fighting alcohol harm: The EU's strategy under review
Early 2016: Final ruling on the MUP in Scotland ny the European Court of Justice.
Alcohol Minimum Unit Pricing
EURACTIV Members


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Q: Java getting output from program executed in command line when it constantly updates a single line in the command prompt I have a quick question about getting output from specific instances of programs my java program runs through the command line. I am able to get the output for programs as long as they output multiple lines, but if it is a program that updates the current line I seem to be out of luck. For example when I try to convert an mp4 to an mp3 using ffmpeg it will only have a single line with the files current size and time taken to run which I can't seem to get when running it through my java program. Here is the code I use which works when there are multiple lines:
InputStream is = pr.getInputStream();
    InputStreamReader isr = new InputStreamReader(is);
    BufferedReader br = new BufferedReader(isr);
    String line;
    System.out.printf("Output of running %s is:\n",
            Arrays.toString(command1));
    while ((line = br.readLine()) != null) {
        System.out.println(line);
    }

    try {
        int exitValue = pr.waitFor();
        System.out.println("\n\nExit Value is " + exitValue);
    } catch (InterruptedException e) {
        e.printStackTrace();
    }

Any help would be much appreciated! Thanks!

A: I think I see what's going on. readLine() is looking for a '\n' character. Single-line programs emit a '\r' to return to the beginning of the line and re-write it over and over.
I read around commons-io and javadocs and neither of them have a readLine(char c) which would read until a particular character is encountered, so unfortunately I think you have to code this up for yourself. :\

A: If you use br.readLine() you need to be certain that it is terminated.
From javadoc https://docs.oracle.com/javase/7/docs/api/java/io/BufferedReader.html#readLine()

Reads a line of text. A line is considered to be terminated by any one of a line feed ('\n'), a carriage return ('\r'), or a carriage
  return followed immediately by a linefeed.

Using read() only and printing the characters one by one might be easier

redpajama_set_name: RedPajamaStackExchange


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Electro-Harmonix's Canyon Delay & Looper was released in early 2017, and by the end of the year it topped our list of best-selling new pedals.
Today, EHX announced the brand-new Grand Canyon Delay & Looper, which greatly expands on the capabilities of its predecessor.
While it keeps the three-second delay time, the Grand Canyon offers 12 effect types (as opposed to the Canyon's 10): Echo, Mod, Multi, Reverse, DMM (which is fashioned after the classic Deluxe Memory Man tone), Tape, Reverb, Pitch, Shim, Sample/Hold, Drum, and Doubler.
The Drum effect is brand-new to the Grand Canyon and emulates the magnetic drum echo of the Benson Echorec. The Doubler makes use of the new pedal's stereo outputs to make a left-to-right stereo spread or add heft to a mono signal. Meanwhile, the Looper function—which was limited to 62 seconds on the Canyon—now has 16 minutes of total recording time, allowing for unlimited overdubs and sonic experimentation.
Watch EHX's official release video below, and click here to order yours now on Reverb.
Electro-Harmonix Grand Canyon Delay & Looper release demo.


If you haven't seen the above video "Walmart" by Mr. Ghetto, it was only a matter of time. When a friend in New Orleans first sent this to us yesterday it had about 40,000 views. It's up to nearly half-a-million views now. This thing has viral written all over it.
We bring Mr. Ghetto and his Walmart song up for those of you who have been watching this season of David Simon's Treme on HBO. This is what the character of Davis–a New Orleans local–is talking about when he regularly extols the glories of "Bounce." Davis is constantly harping on Bounce as a legitimate form of musical expression in the great New Orleans tradition. This Fishie personally feels that Treme, though an otherwise wonderful show, is inadvertently sullying the reputation of the city of New Orleans and her citizens. Because, as you can see, Bounce is absolutely ridiculous.
Yes, people in New Orleans like Bounce music. It is popular and widely played and enjoyed. But the operative phrase to describe the vast majority of people's reception to this music is "ironic detachment." It is, quite simply, so bad it's funny– and is therefore considered "good." Plus you can dance to it.
For the benefit of Mr. Simon and his writing crew, I'll allow this video to demonstrate my point.
Attention Tim Goodman: feel free to make note of the above for your next Power Rankings column. Treme is a great show, but clearly needs to drop a spot or two for essentially advocating "Walmart" as a culturally invaluable form of musical expression.
Incidentally, this Fishie used to live two blocks from the Walmart in question. Amazingly, he's seen stranger things than Mr. Ghetto happen in the parking lot.
*Update: YouTube inexplicably decided to remove the "Walmart" video, citing its "sexual content." Garbage. We had to switch to Perez Hilton's rip of the video.


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text:
Safety and Robustness for Deep Learning with Provable Guarantees (AAAI-22 Invited Talk)
Marta Kwiatkowska (University of Oxford)
{ "name":"Safety and Robustness for Deep Learning with Provable Guarantees (AAAI-22 Invited Talk)", "description":"", "startDate":"02-26-2022", "endDate":"02-26-2022", "startTime": "07:30", "endTime": "08:30", "location": "Red Plenary Room, Blue Plenary Room", "timeZone": "US/Pacific", "options":[ "Apple", "Google", "iCal", "Microsoft365", "Outlook.com", "Yahoo" ] }
Abstract: Computing systems are becoming ever more complex, with automated decisions increasingly often based on deep learning components. A wide variety of applications are being developed, many of them safety-critical, such as self-driving cars and medical diagnosis. Since deep learning is unstable with respect to adversarial perturbations, there is a need for rigorous software development methodologies that encompass machine learning components. This lecture will describe progress with developing automated certification techniques for learnt software components to ensure safety and adversarial robustness of their decisions, including discussion of the role played by Bayesian learning and causality.
Marta Kwiatkowska is Professor of Computing Systems and Fellow of Trinity College, University of Oxford. She is known for fundamental contributions to the theory and practice of model checking for probabilistic systems, and is currently focusing on safety, robustness and fairness of automated decision making in Artificial Intelligence. She led the development of the PRISM model checker (www.prismmodelchecker.org), which has been adopted in diverse fields, including wireless networks, security, robotics, healthcare and DNA computing, with genuine flaws found and corrected in real-world protocols. Her research has been supported by two ERC Advanced Grants, VERIWARE and FUN2MODEL, EPSRC Programme Grant on Mobile Autonomy and EPSRC Prosperity Partnership FAIR. Kwiatkowska won the Royal Society Milner Award, the BCS Lovelace Medal and the Van Wijngaarden Award, and received an honorary doctorate from KTH Royal Institute of Technology in Stockholm. She is a Fellow of the Royal Society, Fellow of ACM and Member of Academia Europea.

redpajama_set_name: RedPajamaCommonCrawl


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Vera Kovarsky, née Vera Rebeka Emila Kovarsky à Daugavpils (alors Dvinsk) en Lettonie le  et morte à Montpellier (Hérault) le , est une psychologue française, spécialiste de l'orientation scolaire et des enfants gauchers.

Biographie

Fille d'Émile Kovarsky et de Dina Schlepianoff, des intellectuels juifs de Lettonie, elle s'installe à Montpellier dans les années 1920 pour y étudier la psychologie infantile à l'Université de Montpellier, auprès de Marcel Foucault, professeur de linguistique et de phonétique.

Elle soutient le 6 juillet 1927 sa thèse de doctorat, intitulée Profil psychologique de M. le professeur Rossolimo : méthode de mesure des capacités psychiques chez les enfants et les adultes, normaux et anormaux. Le principe est de dépister les enfants ayant des difficultés scolaires pour pouvoir les orienter vers des parcours plus adaptés, grâce à une série de tests qui sont présentés de façon détaillée. Dans l'année qui suit, elle la publie chez Alcan ; le Journal des débats politiques et littéraires s'en fait l'écho le 26 avril 1928 dans sa rubrique Revue des sciences, en critiquant toutefois la complexité de la méthode.

Elle encourage ensuite la ville de Montpellier à instaurer un service d'inspection psychologique, ce qui était alors une nouveauté absolue. Elle assume le rôle d'inspectrice psychologique, qui deviendra par la suite celui de psychologue scolaire.

Les articles sur son sujet parus dans Le Petit Méridional dans les années 1920 et 1930 la décrivent comme vivant dans le dénuement (« Mademoiselle Vera Kovarsky, pourtant, ne mangea pas que du pain blanc dans notre ville. Le noir même lui fut souvent rare. [...] La chambre, où vit et travaille  Vera Kovarsky, a tout d'une cellule de cloître. Le lit, étroit, de fer ; des meubles faits de trois planches, une table éclairée par quelques photographies de savants, des murs à la chaux. »).

Les archives des délibérations du conseil municipal permettent de retracer les indemnités mensuelles qu'elle percevait pour ses fonctions : en 1930 par exemple son emploi de psychologue scolaire, à titre temporaire, est maintenu pour une indemnité de , jusqu'au 30 juin 1930. En 1930 son indemnité de , considérée comme peu élevée, est portée à  à partir du  puis en 1935 au montant de , « devant l'importance chaque jour plus grande que prend le rôle des psychologues pour le dépistage des enfants anormaux et pour l'orientation professionnelle des enfants terminant leurs études ».

En 1941, elle est priée de cesser toute activité dans les écoles communales, en application de la loi du 30 octobre 1940 portant statut des juifs. Elle n'est réintégrée qu'après la Libération : le Conseil municipal du 20 avril 1945 note que la somme qui lui était payée mensuellement (en 1940 ) avant la guerre constituait non un salaire mais une indemnité, et propose le 8 janvier 1946 de la monter à  (ce qui ne compense pas l'inflation de cette époque).

Elle devient par la suite chef du laboratoire de phoniatrie dans le service d'otorhinolaryngologie du professeur Terracol à Montpellier.

Elle est décédée, célibataire, à l'âge de , à Montpellier, sa ville d'adoption.

La réhabilitation des gauchers

Dès 1937, Vera Kovarsky propose au premier Congrès international de psychiatrie infantile une communication intitulée Quelques troubles de l'intelligence et du caractère chez les gauchers où  elle soutient la  thèse selon laquelle « la gaucherie ne se corrige pas plus que la droiterie ». En 1938 à l'Académie des sciences, elle estime que « l'interdiction faite à un enfant gaucher de se servir de la main gauche provoque toujours chez lui des troubles fonctionnels qui en font un inadapté scolaire ». Elle fait le lien en particulier avec le bégaiement dans certains articles comme Gauchers contrariés et phonopathies en 1948. Elle multiplie les interventions que ce soit auprès de l'opinion publique ou des instances scientifiques de son temps. En 1949, elle dépose même à l'Académie de médecine un projet de « Charte des droits fondamentaux du gaucher » puis publie un « Plaidoyer en faveur des gauchers » en 1953. Mais la sensibilisation que Vera Kovarsky avait entreprise pendant plus de vingt ans n'a été suivie que de peu d'effets, en tout cas pas avant les années 1960 en France.

Selon Sylvain Wagnon, « pendant des décennies, Vera Kovarsky entreprend une sorte de « croisade » pour faire connaître les troubles des gauchers contrariés, les liens entre surdité verbale et gaucher contrarié, les liens entre bégaiement et gaucher contrarié, les maladies de voix et la nécessité du dépistage des gauchers ».

Activité littéraire

Conférences
Elle donne une conférence sur Fiodor Dostoïevski en avril 1931, une sur le mysticisme anglais en novembre 1931.

Thèse, ouvrages et articles

Psychologie

Littérature
Elle est l'auteur d'un recueil de poèmes en proses, À Montpellier, soleil du Languedoc ().

Traductions
Elle a traduit du russe le neurologue Grigory Rossolimo (1860-1928), dont la méthode était le sujet de sa thèse de doctorat ès lettres à la Faculté de Montpellier.

Notes

Bibliographie
 (ouvrage réédité en 2008 sous le titre Histoire des gauchers aux éd. Imago)

Liens externes

Naissance en février 1896
Naissance à Daugavpils
Psychologie scolaire
Psychologue français
Décès en octobre 1973
Décès à Montpellier
Décès à 77 ans
Page sans Infobox SHS souhaitée

redpajama_set_name: RedPajamaWikipedia


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Prof. Muller Publishes Two Research Papers with Cover Features
Prof. Gilles Muller recently published two research papers with two alumni of his research group in the Dept. of Chemistry at SJSU. One of the papers, published in the Journal of Materials Chemistry, is titled Tuning CPL by helical pitch modulation in helically-flexible small organic multichromophores (below top). This work is in collaboration with Prof. Santiago de la Moya at the Universidad Complutense de Madrid and involved contributions from Prof. Muller's student Muzuki Johnson. The other paper, titled Vortex Flow-controlled Circularly Polarized Luminescence of Achiral Pt(II) Complex Aggregates Assembled at the Air-water Interface Small Methods, was published in Small Methods (below bottom). That was done in collaboration with Prof. Takeshi Naota of Osaka University and involved work carried out by Prof. Muller's student Shing Cho Ma.
Prof. Madalyn Radlauer publishes editoral titled "Games for the Inorganic Chemistry Classroom"
Prof. Madalyn Radlauer recently published an editoral titled "Games for the Inorganic Chemistry Classroom" in the ACS journal Inorganic Chemistry (link). The article highlights educational games as a tool for active learning, also known as Game-Based Learning, in the chemistry classroom. The article aims to inspire instructors to consider chemistry games for their classroom and also to consider crafting games of their own.
Undergraduate researcher and recent physics graduate Camron X. Stokes (Fall 2021) in the Wolcott lab has been recognized for research excellence by the American Chemical Society. The award is in recognition of Camron's recent publication, cover art and resulting patent with nanoscale diamond chemistry and a discovering a new route to manipulate the world's toughest material. The Division of Colloid and Surface Chemistry has selected Camron as a COLL-PUI awardee and will give an invited lecture entitled, " Exploiting the metastable brominated diamond surface for amine functionalization with linear, cyclic and branched amine" at the national meeting of the ACS in Chicago, IL this Fall. Along with giving the invited lecture, Camron will also receive his award placard from the Division of Colloid and Surface Chemistry. Congratulations Camron!
Congratulations to the class of 2022!
Prof. Esker Wins Nuclear Regulatory Commission (NRC) Early Career Faculty Development Grant
Congratulations to Dr. Nicholas Esker, who recently received a Nuclear Regulatory Commission (NRC) early career faculty development grant to support the Esker group's nuclear science and targetry research. Dr. Nicholas Esker and his group investigate methods to produce and study nuclei far from stability. The proposed project will build the necessary capabilities in SJSU's Nuclear Science Facility in Duncan Hall to produce thin film samples of low-activity actinides such as thorium & uranium. These thin films, known as targets, are used in low energy nuclear reaction studies to investigate the production and decay of heavy nuclei. An important component in this project is student training, as this support will introduce SJSU students to nuclear science & train them in various thin film production and characterization techniques. Ultimately, the goal of this project is to revitalize the Nuclear Science Facility with a long-term research active faculty.
Prof. Grazioli Wins CSUPERB Faculty-Student Collaborative Research New Investigator Grant
Congratulations to Prof. Gianmarc Grazioli on winning a CSUPERB Faculty-Student Collaborative Research New Investigator Grant! The New Investigator Grant Program aims to provide recently hired CSU faculty with the resources required to successfully compete for follow-on, externally-funded grants and to involve CSU students in their research programs. This grant will provide salaries to two student researchers, who will work with Dr. Grazioli over the summer, to develop novel software that leverages network statistical models and molecular dynamics to simulate the self-assembly of amyloid fibrils. The formation of amyloid fibrils is central to a variety of human diseases, such as Alzheimer's disease and Huntington's disease.
Prof. Muller Wins CSUPERB Research Development Grant
Congratulations to Prof. Gilles Muller, who won a CSUPERB Research Development Grant to develop streamlined techniques for elucidating chiral structures. Chirality is an important property of majority of biomolecules that greatly influences their function such that only one of the two enantiomeric forms is functional in biological systems. In addition, the increasing applications of optically active substances in various industries (food, agrochemicals, cosmetics, pharmaceutical etc.) has fueled interest in developing methods to recognize and separate chiral enantiomers. The Muller lab uses circularly polarized luminescence (CPL) spectroscopy as a valuable tool to aid in the identification of chiral molecules. The overall goal of this proposal is to further develop CPL as a technique for chiral elucidation, with superior sensitivity, reliability, ease of use, and minimal sample preparation.
Prof. Radlauer Wins SJSU Research Foundation Early Career Investigator Award (ECIA).
Congratulations to Prof. Madalyn Radlauer who received the 2021 Early Career Investigator Award (ECIA) given by the San José State University Research Foundation! The award, presented during the annual SJSU Celebration of Research, recognizes tenure-track SJSU faculty who have excelled in areas of research, scholarship, and creative activity during their probationary period at SJSU. One recipient for this prestigious award is chosen from the College of Science or College of Engineering each year.
Prof. Tran Wins Award from Mission College
Congratulations to Prof. Anh-Tuyet Tran, recipient of the 2022 Academic Senate Excellence Award from Mission College! In addition to her success at Mission College, Dr. Tran has been an integral part of the San José State University Department of Chemistry for many years.
Prof. Kelly Receives Mosher Award
Prof. Resa Kelly was recently awarded the Harry and Carol Mosher Award by the Silicon Valley ACS local section. This award recognized outstanding work in chemistry, advancement of chemistry as a profession, and service to the ACS. Prof. Kelly will present her research at the virtual SVACS Mosher Award presentation ceremony on March 3, 2022.
Prof. Wolcott's Work Featured on Cover
Prof. Abraham Wolcott's work was featured on the cover of the Journal of Physical Chemistry Letters. In the research article, he describes the work to activate the surface chemistry of nanodiamonds. The multi-institute collaboration involved investigators from SJSU, The Molecular Foundry at Lawrence Berkeley National Lab, the Stanford Synchrotron Radiation Lightsource, NIST and the Academy of Sciences of the Czech Republic. The work at SJSU was conducted by a team of students including Cynthia Melendrez, Jorge Lopez-Rosas, Camron X. Stokes, Megan Cheung, Jocelyn Valenzuela, Grace Jeanpierre, Halim Muhammad, Polo Tran, and Perla Jasmine Sandoval. The work has potential applications in biological labeling, magnetic sensing and quantum communication.
Prof. Esker and Colleagues Awarded DOE Grant
A consortium of 17 institutions, including eight minority-serving institutions (MSI) and three DOE national laboratories, has been awarded a $2 million grant from the U.S. Department of Energy (DOE) to establish a first-of-its-kind traineeship program in isotope research and development, production and processing that aims to develop the future isotope production workforce for the nation and the DOE Isotope Program (IP). This novel collaboration, known as the Horizon-broadening Isotope Production Pipeline Opportunities (HIPPO) program, features 17 co-principal investigators across this nation. As a co-PI, Prof. Nicholas Esker will be pursuing thin-film targetry for isotope production while coordinating with and supporting the affiliated MSIs. HIPPO will broaden and diversify the next-generation workforce by promoting innovative and transformative approaches to isotope production and processing as well as student recruitment and preparation. According to DOE Isotope Program Director Dr. Jehanne Gillo. "To ensure a strong and innovative program in the future, it is critical to nurture a broad and diverse workforce."
Highlight on Prof. Van Wyngarden's Work on the ISB
The Fall/Winter issue of the Washington Square Magazine highlighted the work Prof. Annalise Van Wyngarden has contributed to the design of the new Interdisciplinary Science Building (ISB). Prof. Alberto Rascón was also interviewed for the story. The ISB is planned to open in 2023 and will dramatically modernize the facilities for teaching and research in synthetic chemistry and biochemistry.
Prof. Rascón named member of ASBMB's Minority Affairs Committee
Prof. Alberto Rascón was selected to serve on the American Society for Biochemistry and Molecular Biology (ASBMB) Minority Affairs Committee, which is striving to increase cultural diversity through participation, visibility, and status of minorities in biochemistry and molecular biology. Prof. Rascón shared, "As an underrepresented minority scientist, I am deeply humbled to have been selected to continue my efforts in creating a diverse, equitable, and inclusive environment, not only in my classes and research, but also in a very important scientific society."
SAACS Celebrates 80th Anniversary
The Student Associates of the American Chemical Society (SAACS), also known as the Chemistry Club, was founded in June 2021. SAACS hosted a reception in the breezeway of Duncan Hall to celebrate their 80 years at SJSU.
Prof. Wolcott and Colleagues Receive NSF Grant
Prof. Abraham Wolcott, Prof. Wei Wu (Fresno State), Prof. Vivien Luo (Fresno State), Prof. Sara Kassis (Sonoma State), and Dean Elizabeth Wade (Sonoma State) received a $1M National Science Foundation award through the division of undergraduate education. The goal of the project is to use advanced virtual reality and extended reality technology to advance STEM equity at Cal State Universities and community colleges. The grant will assemble a faculty learning community to build the use and expertise of educators with extended reality technology. Contact Prof. Wolcott if you are a SJSU faculty member interested in VR for your classroom ($2,500 stipend, see www.sjsu.edu/wolcott).
Prof. Radlauer Awarded NSF Grant
Prof. Madalyn Radlauer received an NSF award to develop star polymers to enable tandem catalysis, where two or more catalytic reactions occur in the same flask. The polymer will spatially isolate organometallic catalysts, which would otherwise be incompatible, to enable multistep catalysis in a single flask. The funds will also support Prof. Radlauer's goal to expand participation in research by undergraduates at SJSU and local community colleges and to support the development of a mentoring program at SJSU.
Prof. Kelly Wins CoS Award
Prof. Resa Kelly was chosen as the Dean's Scholar, recognizing her research excellence in Chemical Education. Professor Kelly's research interests involve studying how students learn, use and modify their understanding of chemistry concepts and mechanisms after viewing and reflecting on molecular level visualizations. She designs the videos and atomic level animations she studies, and she examines their pedagogical implementation.
Prof. Rascón Wins CoS Award
Prof. Alberto Rascón was recognized for his work mentoring students and involving them in his research on the inhibition of proteases in Aedes aegypti. This mosquito spreads a number of debilitating viruses to humans, so the ultimate goal of the work is to develop a new control strategy to reduce the mosquito population and viral pathogen transmission. Prof. Rascón takes great pride in mentoring undergraduate and masters-level research students and preparing them for jobs in biotech or graduate and professional programs.
Prof. Radlauer Develops Game
Prof. Madalyn Radlauer released a game to help students learn symmetry adapted linear combinations of ligand atomic orbitals. She developed the game with Dr. Zachary Thammavongsy at Chapman University to help students better understand molecular orbital theory.
Women in Science Outreach
Dr. Elizabeth Migicovsky, Prof. Laura Miller Conrad, and Prof. Ningkun Wang recorded virtual story times for the Redwood City Library. The Stories from Your Community: Women in Science event was organized by Dr. Migicovsky and Redwood City Librarian Pam Evans. Check out more of the series at the Redwood City Library.
Prof. Muller's Research Makes Cover
The work of Prof. Gilles Muller, student Shing Cho Ma, and coworkers from the Universidad Complutense de Madrid, Ciudad Universitaria s/n and Universidad del País Vasco-EHU was featured on the cover of Chemical Communications. The research article describes the development of their BODIPY scaffold for use in circularly polarized luminescence, with applications ranging from medical imaging to 3-D display technology.
Congrats, Graduates!
Join us in celebrating the Chemistry class of 2021! See the video below for congratulatory messages from faculty and highlights of our graduates.
Students Compete in SJSU and CSU Research Competitions
Muhammad Khan and Nicholas Roubineau were two of eight student winners of the 2021 SJSU Student RSCA Competition, also qualifying them to represent SJSU at the 35th Annual CSU Student Research Competition. The CSU competition was hosted virtually by Cal Poly Pomona, where nearly 200 student projects were presented across 22 sections. Muhammad won the "Biological and Agricultural Sciences (Undergraduate)" section for his presentation on "Mutagenesis and Recombinant Expression of Aedes aegypti Serine Protease I (AaSPI), a possible N-Terminal Nucleophile (Ntn) Hydrolase."
Muhammad Khan
Muhammad is a Biological Sciences major who conducts research in the Rascón lab, where his research focuses on a serine protease from the Aedes aegypti mosquito, a major vector for virus transmission. This and the other midgut proteases are only expressed after a blood meal has been consumed and are responsible for degrading blood meal proteins into the nutrients needed for egg production. Characterizing the proteases used in blood meal digestion biochemically will aid in the development of an alternative vector control strategy targeting the mosquito.
Nicholas Roubineau
Nick is a Chemistry major and graduating senior whose research interests focus on C-H bond activation using transition metal catalysts. In the Radlauer lab he is studying iridium-catalyzed dehydrogenation of alkanes and ways to enhance the efficiency of this process using synthetic macromolecules as scaffolds for the catalysts. His presentation was titled "Copolymerization of Styrene and Alkene-modified Pincer Ligands to Support Iridium Catalysts for Alkane Dehydrogenation."
Professor Cheruzel Wins University Award
Prof. Lionel Cheruzel was selected as SJSU's Outstanding Professor of 2021, recognizing his excellence in teaching effectiveness and service. He is passionate about enganging a diverse group of students in his research on the development of P450 biocatalysts. In addition, he spearheaded the effort to create the Freshman Initiative: Research to Engage Students (F.I.R.E.S) program. The program, funded by the W. M. Keck Foundation, works to engage Chemistry students in research experiences early in their careers at SJSU.
Wolcott Lab Selected as AEOP Site
Prof. Abraham Wolcott's lab was selected as an Army Education Outreach Program (AEOP) site. Students accepted to the Undergraduate Research Apprenticeship Program (URAP) will receive a $4500 stipend for a 10 week research experience in Summer 2021. The research in the Wolcott lab will focus on the surface chemistry of fluorescent nanoscale diamond, which has applications in biolabeling, biosensing, magnetometry and quantum computation. Students will have the opportunity to perform standard laboratory techniques along with advanced techniques using air and water-free chemistry and synchrotron spectroscopy at the Stanford Synchrotron Radiation Lightsource. The deadline to apply to the URAP program is March 15th, 2021. To apply please visit www.sjsu.edu/wolcott and click on Apply Now.
Professor Cheruzel's Work Makes Cover
Prof. Lionel Cheruzel's work was featured on the cover of the Journal of Inorganic Biochemistry. In the issue, he reviews his work on combining Ru(II) complexes and P450 enzymes to promote catalysis.
Professor Radlauer Receives NIH Grant
Prof. Madalyn Radlauer received an Academic Research Enhancement Award (AREA R15) from the NIH for her proposal entitled "Metallopolymers as Functional Metalloprotein Mimics with Secondary Coordination Sphere Interactions." This grant will fund the Radlauer group's studies on hybrid inorganic/polymer systems (metallopolymers). Their goal is to mimic the catalytic activity, chemical selectivity and complex stability of an enzyme. A successful system will enable challenging chemical transformations relevant to human health that have yet to be accomplished with a synthetic catalyst system.
Join us in celebrating our Spring 2020 Chemistry graduates! See the videos below for highlights of our students and a special message from faculty.
Professor Brook's Work Featured in Chemical Communications
Prof. David Brook had his work featured on the inside cover of Chemical Communications. His research article examines a cobalt-verdazyl coordination compound that switches between two isomers with different electronic configurations when dissolved in solution. The work has potential applications for use as molecular switches.
Professor Singmaster Wins University Award
Prof. Karen Singmaster was awarded the SJSU Distinguished Service Award, recognizing her exemplary service in a leadership capacity. She helps students succeed in the classroom and the research lab through her work as the department chair, the coordinator of General Chemistry, and as the director of the SJSU NIH RISE, SJSU NSF LSAMP and the SJSU NSF S-STEM CoSRaTS programs. Prof. Singmaster also was the recipient of the 2008 SJSU Outstanding Professor Award.
Chemistry Research Students Recognized at ABRCMS
Arturo Chavez and Pomaikai Yamaguchi both won awards for their poster presentations at the 2019 Annual Biomedical Research Conference for Minority Students.
Arturo is a Biomedical Engineering major and NIH RISE student who conducts research in the Miller Conrad lab. He presented a poster on his work to develop new antibacterial treatment strategies by blocking virulence. Inhibition of virulence renders the pathogen more benign, allowing the immune system to clear the infection. Arturo's project targets quorum sensing, the signaling system that controls virulence in many bacteria.
Pomaikai is a Chemical Engineering major and NIH RISE student. She presented a poster on her work in the Prof. Claire Komives lab in the Chemical Engineering Department. Currently she works in Prof. Roy Okuda's lab working to isolate and identify new bioactive molecules from plants native to California.
ABRCMS 2019
Twenty-one SJSU students and six faculty members attended the 2019 Annual Biomedical Research Conference for Minority Students Conference in Anaheim, CA. Many students presented on their research in the department. They were joined by Chemistry Department alumni Rodger de Miranda and Kingsley Okakpu, who are pursuing PhDs at UC Irvine and UC Riverside, respectively.
Professor Wang Receives NIH Grant
Prof. Ningkun Wang was awarded an NIH SC2 research grant to study the allosteric regulation of SIRT1. SIRT1 is an NAD+-dependent protein deacetylase that has been shown to play a significant role in many biological pathways including insulin secretion, tumor formation, lipid metabolism, and neurodegeneration. For this reason, SIRT1 has been identified as a potential therapeutic target, where the regulation of SIRT1 activity could combat diseases such as diabetes, cancer, and neurodegenerative diseases. This progress has been hampered by insufficient understanding of the molecular mechanism of the regulation of SIRT1 activity. Prof. Wang's lab aims to understand the regulatory allosteric interactions between the N-terminal domain and SIRT1's catalytic core. Using biochemical and biophysical methods to clarify how the activity of SIRT1 is altered in various biological pathways and disease states will enable the targeted modulation of SIRT1 activity as a therapeutic method. The project will also provide insight into how other allosterically regulated enzymes function in the cell.
Professor Cheruzel Receives Henry Dreyfus Teacher-Scholar Award
Prof. Lionel Cheruzel was recognized for his commitment to excellence in research and education by the Camille and Henry Dreyfus Foundation. He was one of eight researchers nationwide selected for the Henry Dreyfus Teacher-Scholar Award for his work on "Light-Driven P450 Biocatalysis Featuring Ru(II)-Diimine Complexes." His active research group has included 18 publications with over 35 undergraduate coauthors.
Vanshika Gupta Recognized at CSU Student Research Competition
Vanshika Gupta won the Undergraduate Physical Sciences and Mathematics category of the 33rd Annual CSU Student Research Competition. Vanshika is a Chemistry, concentration in Biochemistry major who researches the synthesis of single chain polymeric nanoparticles in Prof. Madalyn Radlauer's lab. Her presentation was titled "Investigating Macromolecular Structures for the Transformation of Greenhouse Gases into Liquid Fuels." She discussed how these macromolecular structures have the potential to mimic enzymes, enabling challenging chemical reactions related to efficient and selective fuel production.
15th Annual COS Student Research Day and ISB Groundbreaking
In the biggest event yet, over 100 research posters were presented at the 15th Annual College of Science Student Research Day, which has been organized by Prof. Roy Okuda since its inception. Chemistry had a strong showing with 38 posters highlighting the diverse range of research happening in the department. The poster session followed the groundbreaking ceremony for the new Interdisciplinary Science Building. Planned to be completed at the end of 2021, the building will be the future home of the teaching and research labs in synthetic chemistry and biochemistry, in addition to those from molecular biology, microbiology and the high-performance computing center.
Chemistry Research Students Recognized by NSF
Cassandra Villicana
Cassandra Villicana was awarded a prestigious National Science Foundation Graduate Research Fellowship to fund her PhD studies. Cassandra is a Biomedical Engineering major set to graduate from SJSU this spring. She studies a key enzyme involved in conferring antibiotic resistance to Pseudomonas aeruginosa in Prof. Laura Miller Conrad's lab. She will pursue her doctoral studies in Engineering at Stanford University this fall.
Minh Tran
Minh Tran was recognized with an honorable mention on the National Science Foundation Graduate Research Fellowship. Minh Tran graduated with a BS Chemistry, Concentration in Biochemistry degree in Fall 2018. He was also recognized as the department's recipient of the American Chemical Society's Division of Organic Chemistry Outstanding Senior Organic Chemistry Student. Minh also worked in the Miller Conrad lab, developing and testing new compounds to treat drug-resistant strains of P. aeruginosa. He will start his doctoral studies in Chemistry at the University of California, San Francisco this fall.
Dr. Esfandiari Wins University Award
Dr. Melody Esfandiari was recognized with the 2019 University Outstanding Lecturer Award for her excellence in teaching effectiveness and service to SJSU. Dr. Esfandiari got her undergraduate degree at SJSU and returned to teach here in 2012 after obtaining her PhD from the University of California, Irvine. Since that time, she has taught over 3,500 students. She is an advisor of the Student Associates of the American Chemical Society (SAACS) and runs a summer internship program for underrepresented students in science.
Professor Pesek Wins EAS Award
Prof. Joseph Pesek was recognized with the 2019 Eastern Analytical Symposium Award for Outstanding Achievements in Separation Science. A symposium will be held in his honor at the Eastern Analytical Symposium in November 2019.
In SJSU's first fall commencement, the Chemistry Department celebrated 19 graduates from our undergraduate programs.
Students Win Poster Awards at ABRCMS
David Navarro and Jocelyn Valenzuela were both recognized for their poster presentations at the Annual Biomedical Research Conference for Minority Students in Indianapolis, Indiana last November. Both are undergraduates doing research in the Chemistry Department.
David Navarro is a Chemistry major and an NIH RISE student working with Prof. Madalyn Radlauer. David's project aims to enhance the efficiency of fuel production by converting methane, a byproduct of the oil industry, to methanol, a liquid fuel. Taking inspiration from methane monooxygenases, bacterial enzymes that can promote this transformation, David is working to construct synthetic diiron and tri-copper complexes embedded in a polymer scaffold to promote the same transformation on scale.
Jocelyn Valenzuela
Jocelyn Valenzuela is a Chemical Engineering major and an NIH MARC student working with Prof. Abraham Wolcott. Jocelyn is investigating functionalized nanoscale diamonds that have applications in biosensing, voltage sensing and quantum communication. After adding an amine functional group to the surface of the diamonds, she characterized the modification with X-ray absorption and X-ray photoemission spectroscopy at SLAC National Accelerator Laboratory with Dr. Dennis Nordlund and colleagues.
Students Present at ABRCMS
Over 30 SJSU undergraduate students from the NIH RISE, NIH MARC, NSF S-STEM and NSF LSAMP programs attended the Annual Biomedical Research Conference for Minority Students in Indianapolis, Indiana last November. Many presented on their research in the College of Science. The group was led by Professors Singmaster, Ouverney, Rascón and Wilkinson.
No Belles Performance at SJSU
The chemistry club, with the help of the American Chemical Society of Silicon Valley chapter, is bringing a performance of "No Belles" by the Portal Theatre group to SJSU on October 17th. The production raises awareness about gender bias in the sciences, highlighting that of the 581 individuals that have been awarded the Nobel Prize in the sciences, only 18 have been women. The free event will be at 7:30 pm on October 17 in Morris Dailey Auditorium followed by a reception. Register for the free tickets here.
Profs. Pesek and Matyska-Pesek Receive College Award
Profs. Joseph Pesek and Maria Matyska-Pesek were recognized this fall with the College of Science Award for Research with Students. Both have dedicated much time over their careers at SJSU to mentoring students in research, leading to a large number of publications. They received their awards at the fall College of Science Welcome Event.
The Chemistry Department congratulates our 86 graduates from Summer 2017-Spring 2018. Our graduating class includes 8 students with a Master's of Science in Chemistry, 23 students with a Bachelor of Arts in Chemistry, 9 students with an ACS-certified Bachelor of Science in Chemistry, and 46 students with a Bachelor of Science in Chemistry with a Concentration in Biochemistry.
Prof. Radlauer Awarded CSUPERB Grant
Prof. Madalyn Radlauer was awarded a CSUPERB New Investigator Grant in Spring 2018. The funded project is inspired by the question: Can we mimic the macromolecular environment of an enzyme with an organic polymer to achieve effective catalysis? Enzymes, biological catalysts that accelerate reactions, promote numerous impressive reactions in nature. For example, transformations like selective methane oxidation have the technological potential to revolutionize our fuel economy. Thus, Prof. Radlauer turned to nature for inspiration, aiming to mimic the chemical transformations made possible by enzymes. Enzymes generally include an active site – where the reaction occurs – embedded in a larger structure, which provides stabilizing forces to promote the desired reaction. To access enzyme-like activity, the lab hypothesizes that these stabilizing interactions must also be mimicked. This task is nontrivial and remains a significant challenge. The proposed work aims to address the challenge of reproducing secondary interactions by embedding a small molecule "active site" within a larger synthetic scaffold to mimic bacterial enzymes that convert greenhouse gases into useful fuels. In addition to a deeper understanding of enzymes and their structures, success with this type of synthetic system might allow technological leaps for the fuel economy since we would be better able to transform greenhouse gases into viable fuels or industry-relevant chemicals.
Prof. Okuda Wins University Award
Prof. Roy Okuda was recognized with the 2017-2018 Distinguished Service Award. The award is for "exemplary service in a leadership capacity to the university and/or community or profession that brings credit to San Jose State." Prof. Okuda has organized the College of Science Research Day for the past 13 years. He was recognized for this work and for his efforts to create scientific opportunities for students in general. The 14th annual COS Research Day event will be on Friday, April 27, 2018 in the Duncan Hall breezeway.
Professor Joseph Pesek Recieves National Award
After being recognized for research excellence in the CSU last year, Prof. Joseph Pesek has also been honored with the 2018 ACS Award for Research at an Undergraduate Institution. This prestigious award is sponsored by the Research Corporation for Science Advancement and recognizes outstanding research at a primarily undergraduate institution. The work must have received wide recognition and had a large impact on the professional development of undergraduate students. In his research studies to develop new separation methods, Prof. Pesek has published over 230 scientific articles, while working with over 100 undergraduate students. Prof. Pesek accepted the award and presented his work at the 255th American Chemical Society National Meeting in New Orleans, LA. Many faculty from SJSU were able to attend the ceremony.
Undergraduate students from MARC, RISE, LSAMP, McNair, S-STEM and CoSRaTS represented SJSU at the Annual Biomedical Research Conference for Minority Students in Phoenix, AZ. The group of 25 was led by 4 faculty members, including Prof. Karen Singmaster and Prof. Alberto Rascón. A total of 2 oral presentations and 16 poster presentations were given by the students.
Professor Bradley Stone Wins Jazz Award
Prof. Bradley Stone has been recognized with the 2017 Bobby Jackson Award for Jazz Programmer of the Year (Internet and Non-Terrestrial Radio). The award recognized Prof. Stone's programming and production of "The Creative Source" on SoulandJazz.com radio. The program champions radio airplay and greater exposure for new and current "living" artists and jazz composers. He has been the recipient of numerous awards for his work in jazz programming, including the prestigious "Duke DuBois Humanitarian Award" by JazzWeek in 2008, a national award for lifetime achievement and service to the jazz and jazz radio communities. Prof. Stone's work at KSJS-FM at SJSU led to that station's inclusion on the original panels for both the Gavin and JazzWeek national Top 50 jazz charts, as well as KSJS being selected as a 2-time winner (7-time nominee) of the JazzWeek "Jazz Station of the Year – Medium Markets" award.
Professor Madalyn Radlauer Joins Chemistry Department
Prof. Madalyn Radlauer will be teaching courses in inorganic, polymer and general chemistry. As both an organometallic and a polymer chemist, she is looking forward to combining these two areas in her lab, studying small molecule catalysts in macromolecular environments. Like traditional organometallic chemists, students in her lab will synthesize catalysts to lower the activation barrier for challenging reactions relevant to the fuel economy, but these catalysts will then be appended to polymers. Thus, the small molecule catalysts will work as active sites within a larger scaffold, similar to a protein or enzyme. The polymers' ability to alter catalytic activity will be explored, where we expect that this biomimetic approach will have significant effects.
Professor Ningkun Wang Joins Chemistry Department
Prof. Ningkun Wang will be teaching courses in biochemistry. With a background in protein interactions, Prof. Wang's research combines biochemistry and biophysical methods to study indirect allosteric effects on the activity and substrate specificity of enzymes. The general goal of the lab is to study the "supporting actors" in biology that play a major role in the story and to learn how they go about doing that.
Specifically, the lab is interested in studying SIRT1, an enzyme that affects gene expression by de-acetylating transcription factors and histones. SIRT1 has a large, unstructured N-terminus domain that is not directly involved in enzyme catalysis, but regulates the catalytic activity and substrate specificity. The lab will seek to elucidate the mechanism of this allosteric effect by studying the interactions between the N-terminus domain and the enzyme catalytic core.
The chemistry department congratulates its 75 graduates from the 2016-2017 year! Among our undergraduates, we had 8 students graduate with a B.A., 10 with a B.S., and 47 with a B.S. with a concentration in Biochemistry. We also had 10 graduate students receive their master's degree.
Student Research Showcased at SJSU
The 13th College of Science Research Day on May 5th featured 73 posters representing all departments in the college, including 28 posters from the Chemistry department. Prof. Roy Okuda organized the event. On May 6th, SJSU hosted the 29th Annual American Chemical Society Northern California Undergraduate Research Symposium (NCURS). Students from 14 institutions gave oral and poster presentations. The event was supported by the Student Affiliates of the American Chemical Society (SAACS) at SJSU, the ACS Santa Clara Valley Section and the College of Science and organized by Prof. Lionel Cheruzel, Dr. Melody Esfandiari, and Prof. Laura Miller Conrad. SAACS volunteers at the NCURS registration table are pictured.
Professor Joseph Pesek Receives CSUPERB Faculty Research Award
Prof. Joseph Pesek was honored with the Faculty Research Award, which recognizes a California State University (CSU) faculty member for their outstanding work in a biotechnology-related research program. The award includes a $1000 grant and the opportunity to speak during a luncheon at the Annual CSU Biotechnology Symposium, held this year at the Santa Clara Marriott. In his introduction of Prof. Pesek, Prof. Eskandari (Cal Poly Pomona) stated that "Dr. Pesek is being recognized not only for his outstanding research productivity and his dedication to students, but also his persistence in building on theoretical studies to commercialize high performance liquid chromatography (HPLC) products."… [he has] "demonstrated on numerous occasions an intellectual generosity, a willingness to share ideas and an unwavering commitment to scientific rigor that builds excellence in research collaborations at both a national and international level." Over his career he has worked with over 100 undergraduate researchers, served as the primary research advisor for exactly 100 Master's students, and hosted over 50 visiting scientists and postdoctoral fellows from all over the world. His group has published over 230 peer-reviewed papers and garnered $6.95 million in research grants. In the above photo are Prof. Daryl Eggers, Prof. Sep Eskandari (Cal Poly Pomona, Chair of Selection Committee and former award winner), Prof. Joseph Pesek, and Dr. Pamela Stacks (SJSU AVP for Research).
Professor Chester Simocko Joins Chemistry Department
The chemistry department welcomes Prof. Chester Simocko to the department, where he will be teaching courses in organic and polymer chemistry. Prof. Simocko's research bridges the gap between organic chemistry and polymer science. He studies structure-property relationships in polymer systems by considering a desired property (mechanic strength, melting temperature, ion conduction, etc.) and determining how polymer structure affects that property. The lab controls polymer structure by growing a polymer from a surface to create polymer brushes and by making precise polymers and block copolymers for tailored self-assembly via alternating diene metathesis polymerization. Some of the students working on this effort in the Simocko lab are shown above: From left to right: Paul Abarquez, Sandy Rosa, Alexis Sarabia, Andrew Pham, Melvina Lu, Natsu Okuda, Bryan Chin (front), Josh Chen (back), Hamdy Yahya.
Students in the MARC, RISE, LSAMP and CoSRaTS programs presented their biomedical research at the Annual Biomedical Research Conference for Minority Students held in Tampa, Florida in November 2016.
Congratulations, Graduates!
The chemistry department congratulates our 65 graduates in the 2015-2016 year! In addition to 7 master's students, we had 9 students graduate with a B.A., 9 with a B.S., and 40 with a B.S. with an emphasis in biochemistry.
Professor Miller Conrad Awarded an NIH Grant to Investigate Resistance in Pseudomonas aeruginosa
Prof. Laura Miller Conrad was awarded an NIH SC3 Grant to investigate and block antibiotic resistance in Pseudomonas aeruginosa. The bacterium is the leading gram-negative cause of secondary infections in hospitals. Few treatments successfully clear the infection and resistant strains are increasingly encountered. One class of last-resort drugs currently used are cationic antimicrobial peptides (CAPs) like colistin and polymyxin B. Alarmingly, CAP-resistant strains have also been encountered, threatening the efficacy of these life-saving treatments.
The positively-charged CAPs enter the bacterial cell by electrostatic attraction to the negatively-charged outer membrane of P. aeruginosa, followed by disruption of the membrane. Once inside, the drug binds intracellular targets, killing the bacterium. In resistant strains, P. aeruginosa modifies its outer membrane to become less negatively charged, preventing uptake of the antibiotic. With the grant, the Miller Conrad lab will aim to inhibit a biosynthetic enzyme in the modification pathway, forcing the bacterium to maintain a negatively-charged outer membrane and to remain susceptible to CAP treatment. A successful inhibitor could be used in a combination therapy with the CAP antibiotic. Ken Choi and Sarah Matthews shown above are among the students working on the project.
Professor Rascón, Jr. Awarded an NIH Grant to Study Aedes aegypti Midgut Proteases
Prof. Alberto A. Rascón, Jr. was awarded an SC3 research grant from the NIH. The project will investigate the role midgut proteases play during the blood meal digestion process in the virus-carrying Aedes aegypti mosquito. The mosquito specifically feeds on humans to obtain the nutrients needed for the egg laying process, and it is this blood-feeding behavior that facilitates the spread of blood-borne pathogens including Yellow fever, Dengue fever, Chikungunya, and the Zika virus, which has recently emerged in the Americas. At the moment, the only way to minimize pathogen transmission is through mosquito (vector) control. Current strategies include the use of insecticides, which have proven effective in reducing the mosquito population and slowing down pathogen transmission. However, there has been an increase in Ae. aegypti mosquito resistance to available insecticides and with increasing world population, global warming, urbanization, and the lack of other effective mosquito control strategies, the mosquito population will continue to grow. As a result, we will likely experience higher incidences of Dengue, Chikungunya, and Zika infections. The strategy being investigated in the Prof. Rascón, Jr. lab is to target the proteolytic enzymes involved in the blood meal protein digestion process, which should have a negative affect on egg development, reduce the mosquito population, and hence reduce pathogen transmission.
Students and Faculty Attend ABRCMS
A group of SJSU students and faculty attended the Annual Biomedical Research Conference for Minority Students in Seattle on November 11-14, 2015. At this conference students can present scientific research they have performed with faculty. The students are participants in the MARC, RISE, LSAMP and CoSRaTS programs housed in the College of Science. Five students received awards for their presentations. MARC students Jessica Ballin (Psychology) and Rebecca Sandoval (Psychology) presented research performed during the summer at the University of Illinois, Urbana Champaign and University of Michigan, respectively. Awardees from the RISE program presented work done with faculty at SJSU. These students are Fauna Yarza (Biological Sciences, Professor Elizabeth Skovran), Elvia Silva (Biological Sciences, Professor Tzvia Abramson) and Adrian Riives (Chemistry, Prof. Gilles Muller).
Chemistry Department Receives Equipment Donations
Two mass spectrometers were donated to the department this fall, giving students experience with state of the art equipment. The Prof. Joseph Pesek's research group received a Perkin-Elmer liquid chromatography/mass spectrometry (LC/MS) instrument donation for use by CHEM 55L students. A new gas chromatography/mass spectrometry (GC/MS) instrument was donated by the Santa Clara Valley Water District and will be used in Prof. Roger Terrill's CHEM 155 class. This is the second donation from SCVWD - the first was an inductively coupled plasma-optical emission spectrometer system (ICP-OES).
Professor Kelly Receives NSF Grant to Develop a Visualization Framework for Chemical Reactions
Prof. Resa Kelly was awarded a $265,924 grant from the National Science Foundation – Division of Undergraduate Education - IUSE Program to design effective strategies to develop and present molecular visualizations that support student learning in General Chemistry. The framework will present students with a video of experimental evidence followed by animations in variance to each other. The student will be charged with critiquing the animations in connection to the experimental evidence to decide how the animations are similar to or different from the evidence and each other. Ultimately, they will be asked to reflect on the accuracy of each animation. The understanding and insights revealed through this endeavor, regarding how visualizations can enhance student success, will be of significant value to educators across a wide range of scientific disciplines, from biology, to earth sciences, to physics and more.
Professor Muller Leads Research Seminars in Japan
Prof. Gilles Muller was invited by the Japan Society for the Promotion of Science (JSPS) to visit several Japanese universities (Osaka City University, Osaka University, Toyama University, Tsukuba University, Nara Institute of Science and Technology, Kinki University and Kwansei Gakuin University) in June 2015 to participate in educational and scientific discussions and to lead lectures and research seminars. Internationally recognized for his work in promoting excellence in research and for successful mentoring of high school, undergraduate, and graduate students, Prof. Muller is one of the few researchers in the world studying circularly polarized luminescence. During his month-long visit, Prof. Muller also shared the mission of his research group which is to facilitate and increase undergraduate research as a teaching and mentoring tool at SJSU.
Professor Pesek and Dr. Matyska-Pesek Receive Grants from Brazilian Government
Prof. Joseph Pesek received a grant from the Brazilian government agency (CNPg) associated with Ministry of Science and Technology and Dr. Maria Matyska-Pesek received a grant from Brazilian government agency (CAPES) linked to Ministry of Education. Grants are devoted to development of new separation methods for analysis of different food products, impurities in food, main components and monitoring the changes in food after food processing. Both researchers spent two weeks in Brazil at the Federal University in Pelotas this summer.
For older news, check out our News Archive.


Regulation (EC) No 668/2008 is replaced by Regulation EU No 1035/2011 of 17 October 2011 laying down common requirements for the provision of air navigation services.
The ensure that working methods and operating procedures of the air navigation service providers comply with the relevant ICAO standards.
Working methods and operating procedures of providers of communication, navigation and surveillance services shall comply with Annex 10 - Aeronautical Communications, Volumes I to V respectively.
This page was last edited on 11 September 2017, at 07:51.


Yesterday, for an unexpected treat, I decided to take the boys out to lunch at Swiss Chalet. As the three of us approached the restaurant entrance, we met up with an elderly couple who were moving quite slowly and struggling with opening the heavy door. I smiled at them and moved to take the door handle from the gentleman (who was walking with a cane), but he cheerfully insisted he hold the door for me and the boys instead. Once we were all inside, the man and his wife began a friendly conversation with us, asking Noah and Will if they had had a nice Christmas and if Santa had been good to them. The man then asked to shake the boys' hands and wish them a happy new year, and when Will shook his hand, the man said jovially, "Oh, look what fell!". He had slipped a hard wrapped candy into Will's palm with his handshake, and he proceeded to do the same for Noah and I when he shook our hands and wished us all the best in 2012. This elderly couple was so sweet and kind to all of us, and chatting with them started our lunch off on a happy note.
Once he pulled some little papers with jokes on them (the kind you get in Christmas crackers) from his pocket and entertained the boys with his enthusiastic telling of riddles. At the end of our lunch, the man told me with a gentle smile what clever boys I had, and that he was glad for the mix-up with their friends, because talking with us had really helped make his day. I'd be lying if I said I wasn't moved by his genuine, heartfelt sentiments, or that I didn't feel the same way myself. The boys and I all agreed that we were really glad we had decided to go out for lunch on that particular day.
Several hours later, I was thinking about the events of the lunch hour and I realized that our experience had gone against everything I have taught Noah and Will about personal safety. Like many parents today, I have repeatedly told my boys that they should not talk to strangers, nor should they ever take candy from someone they don't know. (For the record, I did tell the boys afterwards that we were throwing out the candies the man had given us because we didn't know the person they had come from, to which Will very seriously replied, "Yes, and anyway, who knows how long that candy might have been in his pocket. That man was VERY old!".) I thought about how I maybe should have handled things differently to send a consistent message to the boys, but in my heart it felt sad to think that we might have just ignored these two kind people. We live far from most of our extended family, and the boys rarely have opportunities to interact with people from much older generations. The delight in both the boys' and the old man's eyes as they spoke with each other showed me that there was a real human connection made between them, and I was forced to face the complex truth that sometimes, a stranger is just a sweet 80-something year old man in Swiss Chalet who carries candies and Christmas cracker jokes in his pocket and tells you that your boys remind him of his own two sons when they were young long ago.
Experiences like these remind me that parenting is tricky business sometimes. While it would be nice to be able to clearly explain to the boys the differences between good and bad, right and wrong, in simple black and white terms, the truth is, sometimes in between there are some really lovely shades of gray.


The device routes Video / Audio from 5 different input sources to your single HDMI display unit. Controllable by the buttons on the switch or by the remote control to select an input signal source.
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Suitable for monitors which have a seperate/detachable monitor cable.
Remote or manual (by button) select HDMI input signal.
For computer / Camera with mini HDMI output connects to your monitor / TV / projector which is HDMI connection.
Source signal: HDMI to destination signal: VGA + Audio for VGA monitor / projector etc.


text:
Executive Director and Co-Founder
Falcon Petroleum Limited
Audrey N Joe-Ezigbo is a serial entrepreneur with 20years business and entrepreneurial experience. A lover of academics and firm believer in personal development, Audrey holds several Master's degrees and executive certifications in the areas of Finance, Marketing, Business Administration, and Leadership from amongst others the University of Nigeria, and the prestigious Lagos Business School and Harvard Business School. She is a dynamic Speaker, a Facilitator and highly experienced Trainer on various facets of management, entrepreneurship, and business strategy.
ENTERPRISE: Audrey co-founded Falcon Petroleum Limited with her husband in 1994 and serves as Executive Director, Commercial Operations with principal accountabilities in the areas of Finance, Business Development, and Commercial Strategy. Falcon Petroleum, an ISO 9001:2008 certified company, is a wholly indigenous leading provider of Engineering, Procurement & Construction (EPC), Pipeline Construction and Maritime Support services to the Nigerian Oil & Gas industry. Falcon Petroleum is also one of the three licensed Local Distribution Companies (LDC's) operating within Nigeria's domestic gas sector, with responsibility for design, development, operation and management of Natural Gas pipeline distribution network & supply infrastructure within the Ikorodu Natural Gas Distribution zone. As a testimonial of its great strides in the gas industry, Falcon Petroleum Limited has received several recognitions and awards over the years for the company's role in facilitating the commercial and industrial exploitation of the abundant reserves of Natural Gas on the domestic front in Nigeria. Audrey is also Managing Director and principal strategist of Falcongaz Limited, a company which she also co-founded with her husband in 2003 and which is renowned within the Oil & Gas and other non-allied service sectors for its expertise in the provision of Engineering Construction, Project Management, and Technical Maintenance Services which satisfy global engineering and safety standards.
Audrey Joe-Ezigbo sits as Chairperson and as a member of the Boards of several corporations. She has served for several years in different capacities on the Executive Council of the Nigerian Gas Association, the umbrella association for professionals and businesses involved in the Nigerian gas industry.
COMMITMENT TO WOMEN DEVELOPMENT: Audrey gives of herself in service to society, humanity and womenfolk in particular through various avenues including her roles as Co-Founder and Member, Board of Advisors Woman Act Now (WAN) Nigeria Chapter, a non-profit organization set up to provide affordable mentoring and coaching to women, thereby helping them to live, learn and launch their dreams. She is a member of the International Women's Society (IWS) a non-profit socio-philanthropic society committed to improving the lives and culture of women worldwide. Audrey served on the Executive Committee of IWS as the Programs Secretary until November 2013, receiving an award for exemplary service during her stay in office. She is also a member, Women in Management, Business & Public Service (WIMBIZ) - a non-profit professional association with the mandate to act as the catalyst to elevate the profile and empower women in these areas.
MENTORING & PEOPLE DEVELOPMENT: An encourager by nature, Audrey's personal mission is to add value to the lives of everyone who she meets. She is particularly passionate about mentoring early-stage and growth phase entrepreneurs towards moving their lives and business potentials to greater heights of achievement. She therefore gives of her time freely in service as a mentor on the formal Mentoring programs of Lagos Business School (LBS), Women in Management, Business & Public Service WIMBIZ, Apostles in the Market Place (AiMP), and on the Federal Government of Nigeria's Youth Enterprise With Innovation in Nigeria (YouWiN!) women's enterprise development & mentoring program. She also readily lends herself to sharing her knowledge and experience as a speaker and facilitator for various establishments including the Lagos Business School and Fate Foundation.
WRITER & PUBLISHED AUTHOR: A prolific writer and author, Audrey Joe-Ezigbo has two published books "Uniquely Woman" and "Double Impact" to her credit. She anchors the Parenting page of Today's Woman (TW) magazine, a leading Nigerian lifestyle magazine. She runs an inspirational, self-development, faith-based blog for women - Uniquely Woman (http://uniquely-woman.blogspot.com) which is designed to guide women towards their full understanding of themselves, guiding them into intentionally fulfilling their aspirations and potentials.
Audrey Joe-Ezigbo is very happily married to Joe - her business partner of 20years and best friend of 24years, and they are blessed with four exceptional children.


text:
Q: Store references to self I am trying to create a network of nodes in Rust, where I want every node in the network to be aware of every other connected node. I thought that this could be done with weak Rc's, like this:
use std::cell::Cell;
use std::cell::RefCell;
use std::rc::Rc;
use std::rc::Weak;

struct Node {
    name: String,
    known_nodes: Rc<RefCell<Vec<Weak<Node>>>>,
}

impl Node {
    fn connect_to_network(&mut self) {
        self.known_nodes
            .borrow_mut()
            .push(Rc::downgrade(&Rc::new(*self)));
    }
}

fn main() {
    let known_nodes = Rc::new(RefCell::new(Vec::new()));
    let node_one = Node {
        name: "node1",
        known_nodes: known_nodes.copy(),
    };
    node_one.connect_to_network();
    let node_two = Node {
        name: "node2",
        known_nodes: known_nodes.copy(),
    };
    node_two.connect_to_network();
}

This however yields

cannot move out of borrowed content

at:
self.known_senders.borrow_mut().push(Rc::downgrade(&Rc::new(*self)));

Because *self is moved out of borrowed content in the &Rc::new(*self).
Any ideas, on how each node can keep track of all the other nodes in the network?

A: You should separate your node and your network, because your network must take the ownership of your node to create an Rc (or at least, it must take an already created Rc). Here is a better design that achieves what you want:
use std::rc::Rc;
use std::rc::Weak;
use std::cell::RefCell;

#[derive(Debug)]
struct Node {
    name: String,
}

#[derive(Default, Debug)]
struct Network {
    nodes: Rc<RefCell<Vec<Weak<Node>>>>,
}

impl Network {
    fn add_node(&mut self, node: Node) -> Rc<Node> {
        let node = Rc::new(node);
        self.nodes.borrow_mut().push(Rc::downgrade(&node));

        node
    }
}

fn main() {
    let mut network = Network::default();
    let node_1 = Node { name: "node_1".into() };
    let node_2 = Node { name: "node_2".into() };

    let _node_1 = network.add_node(node_1);
    let _node_2 = network.add_node(node_2);
}

If you want to store a reference to self, you can do this:
use std::cell::RefCell;
use std::rc::Rc;
use std::rc::Weak;

type MutableNode = Rc<RefCell<Node>>;
type Network = Rc<RefCell<Vec<Weak<RefCell<Node>>>>>;

struct Node {
    name: String,
    others: Network,
}

impl Node {
    fn new(name: String) -> MutableNode {
        let node = Rc::new(RefCell::new(Node {
            name,
            others: Rc::new(RefCell::new(Vec::new())),
        }));
        {
            let tmp = node.borrow();
            tmp.others.borrow_mut().push(Rc::downgrade(&node));
        }

        node
    }

    fn add_node(&mut self, name: String) -> MutableNode {
        let others = self.others.clone();
        let node = Rc::new(RefCell::new(Node { name, others }));
        self.others
            .borrow_mut()
            .push(Rc::downgrade(&node));

        node
    }

    fn len(&self) -> usize {
        self.others.borrow().len()
    }
}

fn main() {
    let node_0 = Node::new("node_0".into());
    let node_1 = node_0.borrow_mut().add_node("node_1".into());
    let node_2 = node_0.borrow_mut().add_node("node_2".into());

    assert_eq!(node_0.borrow().len(), 3);
    assert_eq!(node_1.borrow().len(), 3);
    assert_eq!(node_2.borrow().len(), 3);
}

A: Rc::new(value:T) consume the value.Your function only borrow it, so you can't call Rc::new(*self)
I would recommend you to create a Network struct like the above answer. Or you can wrap your node in Rc<RefCell<Node>> like this:
use std::cell::RefCell;
use std::rc::Rc;
use std::rc::Weak;

#[derive(Debug)]
struct Node {
    name: String,
    known_nodes: Rc<RefCell<Vec<Weak<RefCell<Node>>>>>,
}

impl Node {
    fn connect_to_network(&mut self,ref_to_self: Weak<RefCell<Node>>) {
        self.known_nodes
            .borrow_mut()
            .push(ref_to_self);
    }
}

fn main() {
    let known_nodes = Rc::new(RefCell::new(Vec::new()));
    let node_one = Rc::new(RefCell::new(Node {
        name: "node1".into(),
        known_nodes: known_nodes.clone(),
    }));
    node_one.borrow_mut().connect_to_network(Rc::downgrade(&node_one));
    let node_two = Rc::new(RefCell::new(Node {
        name: "node2".into(),
        known_nodes: known_nodes.clone(),
    }));
    node_two.borrow_mut().connect_to_network(Rc::downgrade(&node_two));
    println!("{:?}",known_nodes.borrow()[0].upgrade());
    println!("{:?}",known_nodes.borrow()[1].upgrade());
    drop(node_one);
    drop(node_two);
    println!("{:?}",known_nodes.borrow()[0].upgrade());
    println!("{:?}",known_nodes.borrow()[1].upgrade());
}

Which in this case you don't really need connect_to_network function, you can just add each Weak<RefCell<Node>> to known_nodes directly
If you want the code to look cleaner, you can introduce a new type alias to Rc<RefCell<Node>> like this
struct Node {
    name: String,
    known_nodes: Rc<RefCell<Vec<Weak<RefCell<Node>>>>>,
}

type RcNode = Rc<RefCell<Node>>;

trait Connectable {
    fn connect_to_network(&self);
}

impl Connectable for RcNode {
    fn connect_to_network(&self){
        let node = self.borrow_mut();
        node.known_nodes.borrow_mut().push(Rc::downgrade(self));
    }
}

so then you can call
let node_one:RcNode = Rc::new(RefCell::new(Node {
    name: "node1".into(),
    known_nodes: known_nodes.clone(),
}));
node_one.connect_to_network();


Treyarch brings back zombies for Call of Duty: Black Ops III with Shadows of Evil, a survival coop experience set in the 40s which stars Jeff Goldblum, Heather Graham, Neal McDonough, and Ron Perlman.
all these co-op modes and split screen options. seems while halo is dropping the staple feature of their frachise, call of duty has swooped in and picked up the slack...awesome.
CoD kiddies will lap this up. Wish it would go to PS4 exclusively! Split screen too? Man i havent split screened since N64!! This is the future! This is next gen!
Why PS4 exclusively? I don't understand people's need to spread hate and create divisiveness. What advantage do YOU get from it being PS4 exclusive? (There's NO advantage to PS4 exclusive for Activision, since they're in the business of making money and more platforms = more money).
He's an Xbox fan and somehow this would improve his life.
And celebrating the death of split screen? What's next? 1080p is too many pixels.
A PS4 owning XBOX fan... get it right!
Cod has always been split screen...in multiplayer. Far as I'm aware the campaign still isn't?
I'm surprised this year's Hardened Edition does NOT include the season pass.
This actually makes the whole game for me. Looks fun!
Campaign is...first time since WAW...and it is a glorious return!
A glorious return indeed.. all the raging power of my ps4 driving 60fps split screen with no loss of visual fidelity! Plus we wont have to play online with CoDs 90% userbase of squeeky kids whose balls havent dropped! PS4 lead platform.. its ok to love CoD now.. right?
Given the fact its giving me features i want, its certainly the better option this year, yes. :) it helps that AW was the first time COD has been good since COD4. Woooo!
As much as i've tried to like AW & be open-minded, it was still an exhausting one-dimensional Michael Bay'esque experience. Nothing felt believable but a literal piece of props.
I honestly didn't expect you to be so excited either. This may sound like 'just another CoD rant' but i've tried hard to enjoy it.
Excited is a bit of a stretch. I'm just looking forward to it more so then i have any COD since COD4. Ghosts was garbage and just felt phoned in. but AW felt different to play, and MP mixed up a lot thanks to the exo suits. Mainly though it's the options avaliable for each mode... solo, online, split screen for pretty much every mode on the disc, as it really should be.


In the future, we will experience some very diverse nutritional needs from the elderly. Nevertheless, some nutritional needs can be generalised. Get the great research coverage made by INCluSilver.
As part of the INCluSilver project, which aims to improve the health of the "silver generation",the University of Surrey has made a literature review on the research within the area of nutrition for the elderly. This research is thefirst step to be taken in the process of developing personalised nutrition for the silver population.
Vitamin C is good for people with a low level of vitamin C in their body.
Low vitamin E intake is related to poor health.
The elderly should increase their folate intake only when their folate level is low and their B12 level high, not when their folate level is high.
Intake of omega-3 fatty acids has a positive effect on health.
Intake of monounsaturated fatty acids leads to positive health benefits.
Read more about each member of our distinguished panel of experts here.


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By definition, throat-singing is when a single vocalist produces at least two distinct tones, or overtones, at the same time by manipulating the resonance in the mouth, larynx and pharynx – like human bagpipes.
To anyone who has seen a throat-singing performance — as this video shows — it's magically mesmerizing.
These human bagpipes of Tuvan throat-singers can individually or simultaneously sound like wind, river waters, birds, and even camels.
Sygyt, the brightest style, sounds a bit like bird whistling, with underlying buzzing created by changing the tongue, lips, and palate.
Khoomei, a softer style with slightly muffled tones, is reminiscent of the wind.
Borbannadyr, a style producing a very low, growling sound – similar to the cries of a camel.
It takes more than vocal chords to make this music. It also requires moving the tongue, jaw and lips, with each variation producing a new tone.
Tuva is a tiny autonomous area of Russia, tucked between southern Siberia and Mongolia. Historically semi-nomadic, Tuvans share a cultural heritage with Mongolia, their religions based in Tibetan Buddhism and shamanism. Many Tuvans still tend herds of yaks, sheep, and reindeer, and live in yurts in the summertime. Surrounded by those sounds of nature, Tuvans replicate them in their throats.
Even former Russian Federation President Boris Yeltsin couldn't figure out how these Tuvans sing. When master throat-singer Kongar-ol Ondar sang for him in 1994, President Yeltsin insisted on peeking inside his mouth to see if there was something sneaky going on – like a secret device – making that music.
Where Can I Hear Throat-Singing?
Throat-singing is performed in Mongolia and in the South Siberian regions of Tuva and Buryatia, all part of a rich cultural oral tradition. Kongar-ol Ondar, the "Liberace of Tuvan music" and the singer whose mouth was checked out by President Yeltsin, has been featured in Rose Bowl parades, performed at the Grand Ole Opry, and recorded with Willie Nelson and Frank Zappa. Female Tuvan throat-singers are growing in popularity as well.