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Two more stabbings have been recorded in Gun-Control London.
The unnamed victim was attacked on Upper Clapton Road in Hackney, just across the road from a Shell petrol station.
Police and London Ambulance crews are on the scene.
In a statement, the Met Police said: "Police were called at 14.55 hours to reports that a male had been stabbed in Upper Clapton Road, E5.
Roads have been cordoned off in the area.
The man has been rushed to a hospital in East London.
It comes just one week after police were called to a fatal attack on the same road outside a Betfred bookies.
Earlier today a man was stabbed on a busy rush-hour train in East London.
Last month London took over New York City in murder rate.
Here are more articles on London's stabbing epidemic.


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Su Cheng shakes her head: "I really don't know about this. I have only been in Class A for two weeks…And I'm not really a scholar." Su Cheng said frankly. Perhaps, it was because of the change of class, that she no longer felt depressed and her mood relaxed, Su Cheng continued.
"I am not being modest, my classmates back then were also citizing me greatly for having bad grades."
Huang Yuqi didn't believe her: "Who doesn't know that the last one in the key class is the top student in the ordinary class."
"I am just stating facts."
Su Cheng: "What was your overall score in this monthly exam?"
When asked about the results, Huang Yuqi was feeling a little bit embarrassed: "I didn't do well in the exam, this time I fell off to the Top 75%."
"Congratulations, you have already surpassed the last one ranker from the class A."
"Really? Who was the last one in Class A this time?"
" "Huh?" Huang Yuqi stared at Su Cheng, "What was your rank?"
"Wow! How did you enter the key class before?"
"Turn around and go to Class A, because I couldn't keep up, I volunteered myself to change class."
Hearing Su Cheng's words, Huang Yuqi couldn't help but laugh: "Haha Fortunately, you changed class earlier, the key class is really not suitable for you."
After that, Huang Yuqi patted Su Cheng on the shoulder again: "But don't worry, we are both a scumbag, naturally I will not dislike you."
Su Cheng smiled friendly, but thought in her heart: She still has to work hard to become knowledgeable.
"Xiao Chengcheng." After exchanging a few words both of them became familiar to each other, Huang Yuqi even gave Su Cheng a new nickname.
"What's the matter on your face?" Huang Yuqi asked, looking at the mark on Su Cheng's face.
"I was injured before, this is just the scar and it proves that it is almost healed."
Back at the hospital, the ointment that the nurse gave Su Cheng was really effective. It took only a week, and it was now almost healed. Well, a lot of scabs have fallen off, revealing the new white skin underneath.
"That's good," Huang Yuqi nodded: "Hurry up, these scars have lowered your appearance." ——Looking carefully, Su Cheng is super beautiful, if there were no scars on her face, she may become one of the school grass.
Advance Chapters
S3YOC
IJWLHGRAR
MFBILWMA
Announcement: The novel IJWLHGRAR is finished. Next book to finish is My Fake Brother is in-love with me again, I think It will be able to finish it by June. As for Shrank to a 3-years-old child, will try to finish it by the end of the year this is pretty much long.
Next novel is Running Away with the sick Villain and Sweet Daily life with my Fool and Rich Husband
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Su Cheng shakes her head: "I really don't know about this. I have only been in Class A for two weeks...And I'm not really a scholar." Su Cheng said frankly. Perhaps, it was because of the change of class, that she no longer felt depressed and her mood relaxed, Su Cheng continued.
"I am not being modest, my classmates back then were also citizing me greatly for having bad grades."
Huang Yuqi didn't believe her: "Who doesn't know that the last one in the key class is the top student in the ordinary class."
"I am just stating facts."
Su Cheng: "What was your overall score in this monthly exam?"
When asked about the results, Huang Yuqi was feeling a little bit embarrassed: "I didn't do well in the exam, this time I fell off to the Top 75%."
"Congratulations, you have already surpassed the last one ranker from the class A."
"Really? Who was the last one in Class A this time?"
"Me".
" "Huh?" Huang Yuqi stared at Su Cheng, "What was your rank?"
"87%"
"Wow! How did you enter the key class before?"
"Turn around and go to Class A, because I couldn't keep up, I volunteered myself to change class."
Hearing Su Cheng's words, Huang Yuqi couldn't help but laugh: "Haha Fortunately, you changed class earlier, the key class is really not suitable for you."
After that, Huang Yuqi patted Su Cheng on the shoulder again: "But don't worry, we are both a scumbag, naturally I will not dislike you."
"Xiao Chengcheng." After exchanging a few words both of them became familiar to each other, Huang Yuqi even gave Su Cheng a new nickname.
"What's the matter on your face?" Huang Yuqi asked, looking at the mark on Su Cheng's face.
"I was injured before, this is just the scar and it proves that it is almost healed."
"That's good," Huang Yuqi nodded: "Hurry up, these scars have lowered your appearance." ——Looking carefully, Su Cheng is super beautiful, if there were no scars on her face, she may become one of the school grass.
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After rebirth, I just want to concentrate on raising my baby Vol. 1 Ch. 63
Doting On Wife Like It's His Life, The President Is Determined Not To Divorce Vol. 1 Ch. 48
Doting On Wife Like It's His Life, The President Is Determined Not To Divorce
The Only Person I Bow Down Is Her Vol. 1 Ch. 1
Her Little sweet lover Vol. 1 Ch. 2.1

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text:
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Heed the lessons of Iraq
Paul Heinbecker
Canada was on the right side of history in refusing to go to war in Iraq a decade ago. Three lessons stand out for me from the Iraqi experience.
The first lesson is that, especially in cases of war and peace, we have to make our own judgments and let the chips fall where they may. We should not march off to war out of misplaced loyalty to allies and fellow democracies, as urged by the official opposition of the day. Nor should we "go along to get along" out of exaggerated hopes of benefits or fears of costs on the part of business organizations, pundits and members of the military. In dissenting, it turned out we had nothing to fear but fear itself.
Dissent was the right judgment. I was Canada's ambassador to the United Nations at the time, and it was evident to me that war in Iraq would be a bloody and strategic error, and so it turned out. According to Iraqi Body Count, an independent organization that painstakingly tries to count deaths, at least 111,000 Iraqi civilians have died violently since the war began on March 19, 2003. Nearly 5,000 American soldiers and their allies in the "coalition of the credulous and the calculating" died as well, paying the ultimate price for transitory good relations with a soon-to-be-discredited Bush administration.
All told, more than 170,000 people have perished as a consequence of the Iraq war, and millions have fled the country, perhaps never to return. Nor, as apologists for the war argue, has Iraq become a normal, democratic country. It remains rent by sectarian and ethnic divisions; more than 4,500 Iraqi civilians alone were killed in 2012, according to Iraqi Body Count.
Strategically, the war was a major error. The vast treasure devoted to this enterprise by the United States contributed directly to the size of the deficit that has bedevilled governance in Washington and undermined American foreign policy. The U.S. recourse to war in 2003 as a first – not last – resort over the objections of most of the rest of the world in flagrant disregard of international law so damaged America's reputation that it will take generations to recover.
The loss of reputation also implies the loss of the ability to persuade others to follow. The war was thus the opposite of the success grotesquely still claimed by Dick Cheney, Tony Blair and their neo-con co-conspirators, and the U.S. is still paying for their delusions. Jean Chrétien was right to keep us out of it. Declining to participate was sound, principled foreign policy that enhanced Canada's standing internationally, including among the many Americans who consider the war a mistake.
The second lesson to draw is that one fiasco does not a norm make. Military intervention is sometimes indispensible, and in everyone's interests. Kosovo, Sierra Leone, Ivory Coast, Libya and Mali all qualify as successful international military interventions that saved countless lives. Syria is the most pressing current case for military intercession, despite the fear of making things worse – the diplomatic equivalent of the Hippocratic principle – and despite sheer intervention fatigue.
Four million Syrians have already fled their homes, half a million more have found refuge abroad, upward of 80,000 have been killed and 60,000 are thought to be held in Syrian prisons, subject to torture and disappearance. The infrastructure and cultural heritage of the country are being destroyed bomb by bomb, and neighbouring countries are progressively being destabilized by refugee flows.
Absent effective outside intervention, the crisis seems certain to widen and the destruction of the innocent to worsen. Such intervention need not mean Western boots on the ground; the creation of safe havens and "no fly" zones over those havens is a limited but viable alternative, as they were in Iraq in the years before the 2003 invasion. Intervention fatigue is nevertheless palpable in financially strapped and politically distracted Washington and Europe, and seems likely to stay that way. Others with the means, including Canada, need to accept a greater share of the lead.
The third lesson to draw from the Iraqi experience is that history can repeat itself if political leaders are brazen or incautious enough, senior officials feckless or ambitious enough, the media self-censoring or self-interested enough and populations inattentive or trusting enough.
The march to war in 2003 was replete with hyperbolic claims of the dangers posed by Iraq (the smoking gun that could be a mushroom cloud, according to Condoleezza Rice, George Bush's national security adviser), inflated and outright invented intelligence about Iraqi weapons of mass destruction (Dick Cheney's assertion on Meet the Press that Saddam Hussein had reconstituted his nuclear weapons, as well as Britain's "dodgy dossier" on Iraqi capability), misplaced loyalty (Colin Powell, the U.S. secretary of state, allowing himself to be used in the UN Security Council), hubris about the outcome and disregard of the wider consequences of war ("a cakewalk"), arbitrary deadlines (the fight had to be launched before the hot Iraqi summer) and a massive disregard for international law.
All of these warning signs are present in current attitudes toward Iran. The difference, let's hope, is that, this time, all concerned will remember the lessons of Iraq.
Paul Heinbecker, Canada's ambassador to the UN from 2000 to 2003, is a distinguished fellow at the Centre for International Governance Innovation and director of the Centre for Global Relations at Wilfrid Laurier University.
"History can repeat itself if political leaders are brazen or incautious enough, senior officials feckless or ambitious enough, the media self-censoring or self-interested enough and populations inattentive or trusting enough."
The opinions expressed in this article/multimedia are those of the author(s) and do not necessarily reflect the views of CIGI or its Board of Directors.
With a distinguished career in Canadian diplomacy — including posts as ambassador to Germany, permanent representative to the United Nations (UN) and adviser to various prime ministers, Paul Heinbecker is one of Canada's most experienced commentators on foreign policy and international governance. Paul is also the director of the Centre for Global Relations at Wilfrid Laurier University.
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Matt Gillan to leave the Pass at South Lodge hotel
31 March 2016 by Carol Millett
Chef Matt Gillan is to leave the Pass restaurant at the South Lodge hotel in Horsham, West Sussex, after a 10-year tenure which saw him retain a Michelin star for five years.
Gillan, who departs the Pass in April, has yet to reveal where he is headed.
Exclusive Hotels and Venues, which owns South Lodge, also declined to reveal who will replace Gillan as head chef.
Gillan joined the restaurant at the five-star country house hotel in 2006 and launched the Pass in 2008. During his time there, the Pass won and retained a Michelin star for five years, along with four AA rosettes.
Last year he appeared in the finals of BBC TV show Great British Menu, receiving straight 10 scores from both the chefs and judges Matthew Fort, Prue Leith, Oliver Peyton and guest judge Felicity Cloake for his main dish Teaching and Preaching.
Gillan said the decision to leave "hadn't been an easy one." He added: "South Lodge and the Exclusive team have given me an incredible platform to showcase my skills and creativity and I feel enormously privileged and proud to have achieved so much throughout my 10 years. I shall be very sad to say goodbye, but the time is now right for me to move on and I am looking forward to my next venture."
Exclusive Hotels and Venues managing director Danny Pecorelli said: "We are really proud of Matt and have enjoyed watching his raw talent and ambition develop over the years into the incredible chef he is today. Matt's experimental originality and playful showmanship has secured the Pass's reputation as a vibrant destination restaurant, so I've no doubt of his future success and wish him all the very best."
Exclusive Hotels and Venues has a track record for attracting award-winning talented chefs, including Matt Worswick at Pennyhill Park, Olly Rouse at Lainston House, Rob Potter at the Manor House and Steven Edwards, former head chef of the Camellia at South Lodge and winner of MasterChef: The Professionals in 2013.
Other hotels in the group include Lainston House near Winchester; the Manor House near Bath, Wiltshire and Pennyhill Park in Bagshot, Surrey.
The group also runs two venues - the Royal Berkshire in Ascot and Fanhams Hall in Ware, Hertfordshire - as well as the Manning Heath and Manor House golf clubs.
Exclusive Hotels Chef Academy open for applications >>
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Greater Manchester Mental Health NHS Foundation Trust (GMMH) is one of the leading mental health trusts in the UK. Serving a population of 1.2million people,...
Band 5 RGN - HMP Risley (Band 5) - Mental Health - Greater Manchester Mental Health NHS Foundation Trust
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Greater Manchester Mental Health NHS Foundation Trust–Manchester, City and Borough of Manchester
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Junior Locally Employed Doctor in Child and Adolescent Mental Health (MT03) - Child and Adolescent Mental Health - Manchester University NHS Foundation Trust
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An opportunity has arisen for an experienced occupational therapist to join the Salford Early Intervention Team as an OT care co-ordinator. The successful...
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Home Art Exhibition Continues: "Susan King-Chronicles of a Southern Feminist"
Art Exhibition Continues: "Susan King-Chronicles of a Southern Feminist"
Eleanor D. Wilson Museum 8009 Fishburn Dr, Roanoke, Virginia
King is known both for her writing and her skillful bookmaking. She began making books after she moved to Southern California in the 1970s to be part of the experimental Feminist Studio Workshop. She went on to become the studio director of the Women's Graphic Center at the Woman's Building, working closely with Judy Chicago and other pioneer feminist artists. She has since returned to her roots in Kentucky, and continues to create books and ephemera. Her work is in major collections including The Getty Center Research Institute Library, Bel Air; the Bibliothèque Nationale, Paris; the Museum of Modern Art Library in New York; and the Victoria and Albert Museum Library, London. Exhibit through April 8. Hours are Tuesday through Sunday from Noon-5 pm, with extended evening hours on Thursday until 8 pm.
Location Eleanor D. Wilson Museum 8009 Fishburn Dr, Roanoke, Virginia
Date & Time Apr 1, 2018


SCO delegation heads in Bishkek.
Prime Ministers from SCO member countries met in Bishkek, the capital of Kyrgyzstan, on November 2 and 3 to chart a course for future cooperation among members of the crucial Eurasian organization.
Prime Ministers of the Shanghai Cooperation Organization (SCO) states held the 15th meeting of the Council of Heads of Government in the Kyrgyz capital Bishkek, on November 2 and 3. During the two-day meeting, both in restricted and extended formats, the ministers discussed issues as high priorities for the SCO member-countries.
Key subjects on the agenda included prospects of boosting trade and economic cooperation between SCO members, mechanisms for financial support for project activities between 2012 and 2016, the list of projects for 2017-21, implementation of agreements reached by the Council of Heads of State during the June summit, in Tashkent, and enhancing regional security by jointly countering terrorism, extremism, separatism and illegal drug-trafficking.
Kyrgyz Prime Minister Sooronbay Zheenbekov presided over the meeting attended by all SCO Heads of Government, including Russian Prime Minister Dmitry Medevedev, Chinese Prime Minister Li Keqiang, Kazakh Prime Minister Bakhytzhan Sagintayev, Tajik Prime Minister Kohir Rasulzoda and Uzbek First Deputy Prime Minister Rustam Azimov. The Council of Heads of Government is the second highest body of the SCO, and holds meetings annually to charter the course of development of cooperation between in different fields.
The SCO was established in 2001to tackle regional terrorist threats and promote political, economic and cultural cooperation in the Eurasian region. Russia, China, Kyrgyzstan, Kazakhstan, Uzbekistan and Tajikistan are the founding SCO members. India and Pakistan have been admitted as members of the organization, while Belarus, Iran, Afghanistan and Mongolia have observer status in the grouping. Armenia, Azerbaijan, Nepal, Sri Lanka, Cambodia and Turkey are dialogue partners of the organization, while guests include the trade blocs of ASEAN, the CIS and Turkmenistan.
At the SCO summit in Tashkent in June 2016, India and Pakistan were admitted as full members. They are in the process of fulfilling various obligations in the organization's structures, and will attend the SCO summit in Astana (Kazakhstan) in June 2017.
The prime ministerial participants signed a total of 12 agreements and a joint communiqué at the end of the Bishkek meeting. The agreements comprised the decision to set up the SCO Development Bank, the report of the SCO Secretariat on the implementation of the programme of multilateral trade and economic cooperation, a list of activities for further development of projects within the SCO framework for the period 2017-21, action plan for implementation of the agreement between SCO members on scientific and technical cooperation for 2016-20, the SCO road development plan and the SCO budget for 2017.
This was the first time SCO leaders signed a list of long-term projects within the framework of the SCO, in the areas of trade and economy, finance and banking cooperation, infrastructural development, and environmental protection. Under the SCO road development plan, the countries that do not have access to the sea would be able to use other transport corridors.
"We support the initiative of China and Russia on the creation of the "Silk Road," Kyrgyz PM Zheenbekov said in his address. He said the SCO needed to provide funding for the different projects, because it was necessary to continue work to establish the SCO Bank and the SCO Development Fund. "We need a comprehensive plan of cooperation for the development of industry, trade and the provision of services," he added.
Russian PM Medvedev said that SCO member-countries are effectively cooperating and working together to accomplish a number of tasks, approved by the grouping.
"Despite the current situation and existing economic problems, one can say today that the values at the heart of the project to create the Shanghai Cooperation Organization, have been implemented, and that we work together to address a large number of internal and international tasks, including security matters, crime control, and certainly the accomplishment of topical economic projects relating to infrastructure," he said.
However, he noted that all the economic goals had not been achieved. "We have stated that there are goals we have yet to reach. There are economic tasks we have yet to address," Medvedev said.
Medvedev also drew attention to the need to focus efforts on creating conditions, facilitating the movement of goods, services, investments, and in reaching each other's and third country markets. He also said food and energy security should be the SCO's centre of attention.
Chinese Premier Li called upon the SCO to create a free trade zone to remove trade barriers among the members, to boost trade and economic cooperation. "We are open to cooperation and ready to discuss the creation of a free trade zone. This will help to remove trade barriers," he said. He also sought smooth coordination and dovetailing of development strategies among the members, citing the need to increase synergy between China's proposed "One Belt, One Road" (OBOR) plan and the Russia-led Eurasian Economic Union (EEU).
Andrei Denisov, Russia's Ambassador to China, said on October 31 that China's Silk Road Economic Belt has been adapted to Russia's Eurasian integration programme. "There has been a significant progress in determining the mechanism of interaction between the Eurasian integration project and the Silk Road concept," Denisov said in an interview to Tass.
The joint communiqué also said that initiatives proposed for regional economic cooperation, including China's OBOR plan, are conducive to seeking new models for international cooperation and further strengthening of SCO ties.
The participants also agreed that expanding and deepening cooperation among SCO members is in line with overall interests of the sustainable development of their economies, the communiqué said. They also exchanged views on regional security cooperation, in relation to the volatile situation after a resurgence of terrorist attacks by various radical Islamic groups, including the Islamic State (IS), especially in the Eurasian region.
M.J. Akbar, Minister of State for External Affairs, who represented India, said terrorism is the "single most significant threat" to peace and stability. He welcomed the clear view of the SCO on terrorism from its inception, reaffirming India's strong commitment to combat international terrorism, in all its forms and manifestations.
"We reiterate our strong commitment to combat this menace in all its forms and manifestations, and stress there can be no justification for acts of terror on any grounds whatsoever," he said. "We strongly believe that our fight against terrorism should not only seek to eliminate terrorists, and disrupt terrorist organizations and networks, but should also identify, hold accountable and take strong measures against states which encourage, support and finance terrorism, provide sanctuary to terrorists and terror groups, and falsely extol their virtues," Akbar said.
"We condemn in the strongest terms the recent barbaric terror attacks in the region," he said. Sartaj Aziz, Foreign Affairs Advisor to Pakistani Prime Minister Nawaz Sharif, also attended.
Akbar urged all countries to work to expedite adoption of the draft Comprehensive Convention on International Terrorism (CCIT) in the UNGA without any further delay.
The next annual SCO meet of the Council of Heads of Government will be held in Russia in 2017. Medvedev said he was glad to take on the baton to go ahead.


text:
Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis
K. Liu, Q. Z. Li, Y. Yu, C. Liang, S. Subramanian, Z. Zeng, H. W. Wang, C. Xie, X. J. Zhou, C. Mohan, E. K. Wakeland
Immunology - Microarray Core
Immunology - Administration
Genetic analyses of the lupus-prone NZM2410 mouse have identified multiple susceptibility loci on chromosome 7, termed Sle3 and Sle5. Both of these loci were contained within a large congenic interval, originally termed as Sle3 that strongly impacts a variety of myeloid and T-cell phenotypes and mediates fatal lupus nephritis when combined with Sle1. We have now produced two subcongenic strains, B6.Sle3 and B6.Sle5, carrying the Sle3 and Sle5 intervals separately and characterized their phenotypes as monocongenic strains and individually in combination with Sle1. Neither B6.Sle3 nor B6.Sle5 monocongenic strain develop severe autoimmunity; however, both of these intervals cause the development of severe glomerulonephritis when combined with Sle1. Thus, B6.Sle1Sle3 and B6.Sle1Sle5 exhibit splenomegaly, expansion of activated B and CD4+ T-cell populations and high levels of IgG and IgM autoantibodies targeting multiple nuclear antigens, intact glomeruli and various other autoantigens. In addition, B6.Sle1Sle3 mice also produced higher levels of IgA antinuclear autoantibodies, which were implicated in the development of IgA nephropathy. Our results indicate that Sle3 and Sle5 can independently complement with Sle1, through shared and unique mechanisms, to mediate the development of severe autoimmunity.
Genes and Immunity
https://doi.org/10.1038/sj.gene.6364426
Genetics(clinical)
10.1038/sj.gene.6364426
Dive into the research topics of 'Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis'. Together they form a unique fingerprint.
Lupus Nephritis Medicine & Life Sciences 100%
Autoimmunity Medicine & Life Sciences 80%
Autoantibodies Medicine & Life Sciences 75%
Nuclear Antigens Medicine & Life Sciences 53%
Chromosomes, Human, Pair 7 Medicine & Life Sciences 52%
T-Lymphocytes Medicine & Life Sciences 50%
Liu, K., Li, Q. Z., Yu, Y., Liang, C., Subramanian, S., Zeng, Z., Wang, H. W., Xie, C., Zhou, X. J., Mohan, C., & Wakeland, E. K. (2007). Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Genes and Immunity, 8(8), 634-645. https://doi.org/10.1038/sj.gene.6364426
Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. / Liu, K.; Li, Q. Z.; Yu, Y. et al.
In: Genes and Immunity, Vol. 8, No. 8, 12.2007, p. 634-645.
Liu, K, Li, QZ, Yu, Y, Liang, C, Subramanian, S, Zeng, Z, Wang, HW, Xie, C, Zhou, XJ, Mohan, C & Wakeland, EK 2007, 'Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis', Genes and Immunity, vol. 8, no. 8, pp. 634-645. https://doi.org/10.1038/sj.gene.6364426
Liu K, Li QZ, Yu Y, Liang C, Subramanian S, Zeng Z et al. Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. Genes and Immunity. 2007 Dec;8(8):634-645. doi: 10.1038/sj.gene.6364426
Liu, K. ; Li, Q. Z. ; Yu, Y. et al. / Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis. In: Genes and Immunity. 2007 ; Vol. 8, No. 8. pp. 634-645.
@article{ce1171ad8fe54b91a3014496e419b52e,
title = "Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis",
abstract = "Genetic analyses of the lupus-prone NZM2410 mouse have identified multiple susceptibility loci on chromosome 7, termed Sle3 and Sle5. Both of these loci were contained within a large congenic interval, originally termed as Sle3 that strongly impacts a variety of myeloid and T-cell phenotypes and mediates fatal lupus nephritis when combined with Sle1. We have now produced two subcongenic strains, B6.Sle3 and B6.Sle5, carrying the Sle3 and Sle5 intervals separately and characterized their phenotypes as monocongenic strains and individually in combination with Sle1. Neither B6.Sle3 nor B6.Sle5 monocongenic strain develop severe autoimmunity; however, both of these intervals cause the development of severe glomerulonephritis when combined with Sle1. Thus, B6.Sle1Sle3 and B6.Sle1Sle5 exhibit splenomegaly, expansion of activated B and CD4+ T-cell populations and high levels of IgG and IgM autoantibodies targeting multiple nuclear antigens, intact glomeruli and various other autoantigens. In addition, B6.Sle1Sle3 mice also produced higher levels of IgA antinuclear autoantibodies, which were implicated in the development of IgA nephropathy. Our results indicate that Sle3 and Sle5 can independently complement with Sle1, through shared and unique mechanisms, to mediate the development of severe autoimmunity.",
author = "K. Liu and Li, {Q. Z.} and Y. Yu and C. Liang and S. Subramanian and Z. Zeng and Wang, {H. W.} and C. Xie and Zhou, {X. J.} and C. Mohan and Wakeland, {E. K.}",
note = "Funding Information: We thank Dr Nicolai van Oers for critical reading of this manuscript. We also thank Dr Jose Casco for the management of the mouse colony. This work was supported by grants from the National Institutes of Health (PO1 AI 39824 to EK Wakeland) and Alliance for Lupus Research (EK Wakeland). K Liu was a recipient of National Institutes of Health National Research Service Award (5 F32 AR48058).",
doi = "10.1038/sj.gene.6364426",
journal = "Genes and Immunity",
T1 - Sle3 and Sle5 can independently couple with Sle1 to mediate severe lupus nephritis
AU - Liu, K.
AU - Li, Q. Z.
AU - Yu, Y.
AU - Liang, C.
AU - Subramanian, S.
AU - Zeng, Z.
AU - Wang, H. W.
AU - Xie, C.
AU - Zhou, X. J.
AU - Mohan, C.
AU - Wakeland, E. K.
N1 - Funding Information: We thank Dr Nicolai van Oers for critical reading of this manuscript. We also thank Dr Jose Casco for the management of the mouse colony. This work was supported by grants from the National Institutes of Health (PO1 AI 39824 to EK Wakeland) and Alliance for Lupus Research (EK Wakeland). K Liu was a recipient of National Institutes of Health National Research Service Award (5 F32 AR48058).
N2 - Genetic analyses of the lupus-prone NZM2410 mouse have identified multiple susceptibility loci on chromosome 7, termed Sle3 and Sle5. Both of these loci were contained within a large congenic interval, originally termed as Sle3 that strongly impacts a variety of myeloid and T-cell phenotypes and mediates fatal lupus nephritis when combined with Sle1. We have now produced two subcongenic strains, B6.Sle3 and B6.Sle5, carrying the Sle3 and Sle5 intervals separately and characterized their phenotypes as monocongenic strains and individually in combination with Sle1. Neither B6.Sle3 nor B6.Sle5 monocongenic strain develop severe autoimmunity; however, both of these intervals cause the development of severe glomerulonephritis when combined with Sle1. Thus, B6.Sle1Sle3 and B6.Sle1Sle5 exhibit splenomegaly, expansion of activated B and CD4+ T-cell populations and high levels of IgG and IgM autoantibodies targeting multiple nuclear antigens, intact glomeruli and various other autoantigens. In addition, B6.Sle1Sle3 mice also produced higher levels of IgA antinuclear autoantibodies, which were implicated in the development of IgA nephropathy. Our results indicate that Sle3 and Sle5 can independently complement with Sle1, through shared and unique mechanisms, to mediate the development of severe autoimmunity.
AB - Genetic analyses of the lupus-prone NZM2410 mouse have identified multiple susceptibility loci on chromosome 7, termed Sle3 and Sle5. Both of these loci were contained within a large congenic interval, originally termed as Sle3 that strongly impacts a variety of myeloid and T-cell phenotypes and mediates fatal lupus nephritis when combined with Sle1. We have now produced two subcongenic strains, B6.Sle3 and B6.Sle5, carrying the Sle3 and Sle5 intervals separately and characterized their phenotypes as monocongenic strains and individually in combination with Sle1. Neither B6.Sle3 nor B6.Sle5 monocongenic strain develop severe autoimmunity; however, both of these intervals cause the development of severe glomerulonephritis when combined with Sle1. Thus, B6.Sle1Sle3 and B6.Sle1Sle5 exhibit splenomegaly, expansion of activated B and CD4+ T-cell populations and high levels of IgG and IgM autoantibodies targeting multiple nuclear antigens, intact glomeruli and various other autoantigens. In addition, B6.Sle1Sle3 mice also produced higher levels of IgA antinuclear autoantibodies, which were implicated in the development of IgA nephropathy. Our results indicate that Sle3 and Sle5 can independently complement with Sle1, through shared and unique mechanisms, to mediate the development of severe autoimmunity.
U2 - 10.1038/sj.gene.6364426
DO - 10.1038/sj.gene.6364426
JO - Genes and Immunity
JF - Genes and Immunity


During these studies, my attention was drawn to the striking similarities in the properties of G-proteins with those of tubulin and actin, the major cytoskeletal elements in cells. For example, G-proteins, like actin and tubulin, are associated with the inner aspect of the surface membrane, adhering possibly both through intrinsic membrane proteins, such as receptors, and to membrane lipids. Of particular interest is the fact that all three types of multimeric proteins are subject to regulation by either GTP (G-proteins and tubulin) or ATP (actin) and their hydrolytic products (dinucleotides and Pi). Receptors regulate exchange of bound nucleotides (GDP with GTP) and act catalytically in the process. Similarly, the excursion of a single myosin molecule during muscle contraction along the chain of actin multimers is governed by the exchange of bound ADP with ATP and the hydrolysis of ATP to ADP and Pi. As stated previously, GTP-turnover (production of GDP+Pi) is essential for the rapid and sustained actions of hormones; release of bound Pi is the crucial rate-limiting process in the overall dynamics of signaling. The same is true for myosin/ actin interactions.
With these similarities in structure and regulation, G-proteins can be classified as part of the cytoskeletal matrix, with the primary functional difference that G-proteins serve as chemical signaling devices whereas tubulin and actin serve as mechano-signaling devices. The release of monomers from multimers is the basis for chemical signaling by G-proteins. Dynamic changes in the disaggregation-aggregation cycle of actin and tubulin multimers are also regulatory devices designed for regulating the interactions or movement between specialized components of cells. Based on evidence accumulated over the past decade, all three types of cytoskeletal proteins are connected in some manner to a variety of signaling systems that adhere to the cytoskeletal matrix, including heterotrimeric G-proteins, so-called small molecular weight G-proteins, protein kinases and phosphatases, and other proteins or systems that communicate between the surface membrane and the interior of cells. These components form web-like structures that possibly interact in a flickering manner in response to activation of membrane receptors, including those that are growth promoting.
This is particularly fascinating given the recent breakthroughs in understanding the functional basis of memory formation that point to a physical change in the shape of the synapse (i.e. a cytoskeletal response to a neural action potential) as well as some of the molecular machinery that keeps the synapse in this configuration. My next blog will dig into what is currently known about how memories are formed in more depth.


Calabria was greeted as a very special guest at the European pavilion during the ITB travel fair in Shanghai. The Italian region, newly certified by Welcome Chinese, received the acknowledgement from the hands of Li Zhongguang, vice president of the China Tourism Academy (CTA), the governmental body that officially supports the Certification.
MULTI-FACETED MARKETING - Calabria's efforts to attract Chinese outbound travelers, especially in view of the EU-China Tourism Year in 2018, doesn't end here. In the second half of June, a delegation of travel operators from Mainland China will visit this region in Southern Italy, gathering valuable information about tourist itineraries and experiences. In the meantime, campaigns on WeChat, Weibo and Qunar have been scheduled in order to support the link between the region and the Mandarin-speaking audience.
SYNERGIES AT THE TABLE - Calabria is also building bridges on the gastronomic side by promoting the culture of the chili pepper, a key ingredient in the culinary tradition of both countries. Calabrian food, culture and territory are all key topics that the region is committed to communicating in China, utilizing promotional activities to be developed in the future.


We work with suburbs and rural communities stakeholders involve in agriculture, distribution and marketing of agro-derivates. These stakeholders receive micro credits to finance their activities.
We help micro entrepreneurs on project financing management, book keeping, and auditing. Also, we build manual of procedure for them and carry out accounting training programs.
We do much of tax compliance and tax planning for micro-entrepreneurs and update them on recent finance law on a yearly basis.


Kristen's Concert Picks: Spring into March's Tunes!
March won't let February take the medal for best tunes without a fight! Spring Break's on its way, but with these shows to look forward to, you can party it up all month long. This is going to be amazing!
Athens' much buzzed about songstress is back to kick off our month with her truthful tunes. Enjoy!
Want to be able to say you knew them at the very beginning? The brand new band Groove Tangent rocks the stage for the first time with old favorites Doctor Squid on Thursday at the Melting Point. While Groove Tangent plans to introduce themselves with some awesome covers, they hope to become a fixture in the Athens music scene with their own original songs in the future.
Soft rock is the sound! With southern tunes and dark melodies flowing through her music, Madeline's show will certainly make your night.
After taking quite a hiatus from the music scene, the Winter Sounds return to share their delicious tunes this month with shows on both the 2nd and the 17th at Caledonia. With Today the Moon, Tomorrow the Sun, the 17th's show should be quite a treat for the ears.
WHAT A LINEUP! Several of our favorites will take over the 40 Watt to celebrate the release of Leaving Araby's latest CD. The sheer joy emanating from these bands will make this a most glee-filled night. You won't want to miss this show!
Bands, bands everywhere! The powerfully voiced Betsy Franck brings us an awesome mix of blues and southern rock for the Athens Music Collective Showcase Concert. Eight other bands are scheduled to play as well. Nice!
These guys may be young, but they sure know how to rock! Tealvox has been making a name for itself all over the place, and now you can check them out in their hometown for yourself.
Aman Amun, our favorite electronic soul-searching adventurer, brings his tunes to our yearning ears once more. He's also spreading the musical love at Farm 255 at 10 PM the next day during a Haiti Benefit concert. What wonderful news!
Wild rappers Deaf Judges are back to surprise us with their latest crazy show! What will they do this time? I can't wait to find out!
Oh, how I love them! Venice is Sinking will be here to soothe our troubled hearts with their lovely tunes near the end of March. What joy!
Once again, indie band Romanenko ends our month with their wonderfully dark sound. What a perfect finish!
Wow! These nights are sure to be unbelievable! And don't forget... even more awesome shows will certainly find their way onto this list as I hear about them. Know of a show you want everyone to check out? Comment below, and tell us all about it! See you downtown, my friends!


The Tannourine family restaurant features Lebanese and Mediterranean cuisine. We serve dishes that include an abundance of starches, fruits, vegetables, and meat. Lamb and poultry are highlights of our menu, and we prepare red meat sparingly.
We also offer fresh fish and seafood and purchase limited quantities to ensure that you receive the best of that day's catch. Most often you will find that our food is either grilled, baked or sautéed in olive oil; butter or cream is rarely used other than in the preparation of a few desserts.
Vegetables are eaten raw or pickled as well as cooked.
The cuisine of Lebanon does not boast an extensive list of sauces. Here at Tannourine we instead focus on the use of herbs, spices and especially the freshness of ingredients in the preparation of our savory dishes. The meals are full of robust earthy flavors and like most Mediterranean countries, much of what the Lebanese eat is governed by seasonal changes.
Join us for a meal that is good for the body and soul and savor the cuisines of Lebanon and the Mediterranean!
What is a "mezza?" Traditionally, throughout the Eastern Mediterranean, from Greek to Lebanon, dining on "meze" or "mezze" and "maza" -is a way of life that traces its roots to the beginning of recorded history. The tradition is deeply rooted and is an expression of something Greeks hold dear: socializing over a few plates of simple, delicious food, letting the wine or spirits flow and savoring the liberating, gratifying effects of the meal and drink together.
The word itself means "middle," as in "middle-of-the day," or between meals, because the mezza table is not routinely considered a setting for a full meal.
Usually known as little "tidbits" served on small plates to Westerners, these bites bear a striking resemblance to appetizers or tapas. But that is where the similarity ends. Unlike tapas, mezza is not intended to be bar snacks. On occasion a mezza can even be the entire dinner. Thus mezza dining is an experience shared throughout the Mediterranean, where small savory plates of food are enjoyed in a convivial atmosphere, where friends and family join in the sharing of food and drink; in a relaxing, pleasurable environment.