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Published September 24, 2022 6:38am EDT
Philadelphia police release disturbing surveillance footage in murder of Temple University grad
Philadelphia police said Everett Beauregard, 23, was the victim of an 'unprovoked murder' when he was shot and killed while walking home
By Elizabeth Pritchett | Fox News
Fox News Flash top headlines for September 23
The city of Philadelphia is offering a $20,000 reward for information that leads to the arrest and conviction of the person responsible for killing 23-year-old Everett Beauregard on Thursday.
Beauregard was fatally shot in the 400 block of North 35th Street around 12:30 a.m. Thursday after attempting to return home from a friend's event in south Philadelphia, FOX 29 reported.
He got off a train in the area of 34th and Market streets before walking the rest of the way to his apartment.
Police said surveillance video showed the suspect lingering in the area for more than an hour around 11:21 p.m. before coming into contact with Beauregard.
PHILADELPHIA GIRL GRAZED BY STRAY BULLET TO HEAD AS DOZENS OF SHOTS RING OUT NEAR TEMPLE UNIVERSITY
The Philadelphia Police Department is offering a $20,000 reward for information leading to the arrest and conviction of the person responsible for killing 23-year-old Everett Beauregard.
In the video, the suspect walks past Beauregard before turning around and firing at him from behind. Police said he was struck one time in the back of his neck, severing his spinal cord and causing him to collapse on the sidewalk.
The video then shows the shooter fire another shot at Beauregard while running away.
Surveillance footage captures the suspect in the fatal shooting of 23-year-old Everett Beauregard walking down the street. (Philadelphia Police Department)
FOX 29 said Philadelphia police initially thought the shooting was an attempted robbery, but are now calling it an "unprovoked murder."
SUSPECTED GUNMAN STALKS PHILADELPHIA TEEN GIRL MOMENTS BEFORE DEADLY SHOOTING IN NEW VIDEO
Beauregard was a recent graduate of Temple University. The school released a statement later in the day that said they are "deeply saddened" by his death.
U.S. Rep. Brendan Boyle also commented on the tragedy Friday on Facebook, stating that Beauregard worked as his campaign intern during the 2018 election season.
"I am heartsick to learn the senseless epidemic of gun violence has struck a member of my team, our former campaign intern Everett Beauregard," Boyle wrote. "Everett worked for my campaign during the 2018 election season. He made great contributions to our electoral victory that year. He was a nice, well liked, and purposeful young man with a bright future ahead of him. We will truly miss him and we grieve along with his family and friends during this difficult time."


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The state will organise a call to restructure the management of the Estonian Development Fund's investment portfolio. Both Estonian and foreign bidders are free enter. There are plans to hand over the management of the portfolio from the investment company SmartCap to a new private fund which will continue to keep custody of the state's investments into the current portfolio and will make follow-up investments into the portfolio. Teams with a potential conflict of interest in fund management may be excluded from the call.
In August 2014, the council of the Estonian Development Fund decided to restructure the investment activity of the Development Fund. Ville Jehe, the Chairman of the Council of the fund, said that the Estonian venture capital market has developed rapidly in the last few years due to the activity of SmartCap which was created as an affiliate of the Development Fund. Jehe remarked that considering the current development phase of the venture capital market, the state's role should change and it should concentrate on the shortcomings that the private sector cannot handle.
"The development of the market has reached a stage where there are enough private fund management companies and the state itself no longer needs to provide a fund management service," explained Jehe. From now on, SmartCap's investment strategy will center on funds that finance the activities of accelerators. A procurement was recently announced to find partners for accelerators.
Lehar Kütt, the Director of KredEx, said that the state has to ensure that the current portfolio is managed according to best market practice. "In cooperation with the European Investment Bank, we will announce a call to find a new private fund management company that will continue to manage the state's portfolio investments in rapidly developing companies and will keep making follow-up investments," explained Kütt.
Antti Perli, Member of the Board of SmartCap, emphasized that this is not a sale. In order to restructure the management of investments, a decision has been made not to privatise the assets or outsource the portfolio management service, but to transfer the portfolio and liabilities to a separate fund that will be founded and managed by a new private fund management company. The participation of individuals with a potential conflict of interest in fund management may be restricted. The fund management company chosen in the contest should invest its own finances to the new fund and manage it according to market conditions. Proceeds from previous sales of shares (exits) and companies from which SmartCap will exit before December 31, 2016 will not be transferred.
The fund managed by the private fund management company will continue investing activities based on the existing principles – it will invest in the equity of companies and investments can only be made together with private investors. The risk diversification conditions will also remain the same – up to 10% of the finances may be invested in one company, in exceptional cases this number may rise to 25%. All the candidates can propose the management fee themselves. Perli added that because the fund is currently in the phase of exiting from investments, the fee rate is dependent on the acquisition costs of the managed assets and that it should decrease in the course of the exits. Potential fund management companies can also propose the size of the own contribution.
The detailed terms of the call will be published on the website of SmartCap and based on the current plan, this should take place in the middle of June.
The first step in finding a new fund management company is the submission of applications, this round will take place from the middle of June till the middle of July. In this phase, the candidates will be judged based on their previous activity and experience. Under the direction of the European Investment Bank, a selection committee will be formed. It will be made up of three independent experts and will make the first decision based on the past history of the candidates by August. Qualified candidates will make it through to the second round where they will become thoroughly acquainted with the portfolio and assets and present their visions. By October, the selection committee will make a decision on the winner for which they will consider the candidates' vision for the future. It will be followed by the last stage – technical negotiations with the fund management company that won the contest and the creation of the fund.
The new fund should start operations on January 1, 2017. At the moment, there are 15 companies in the portfolio of the Development Fund and SmartCap. By the start of 2017, the fund should have approximately 10 million Euros of uninvested finances which can be used for follow-up investments in current portfolio companies.


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Gene Editing Market Size Estimation, COVID-19 Impact Analysis, Future Trends, Key Insights and Application By 2023
Market Research Future Releases
Impact of COVID-19 on Gene Editing Market Size, Growth, Share Analysis By Methods (Crispr, Talen, Zfn, Antisense Technology And Others), Applications (Plant Genetic Engineering, Animal Genetic Engineering, Gene Therapy, Microorganisms Genetic Engineering), By End User (Biotechnology, Pharmaceutical, Contract Research Organization) – Global Forecast Till 2023
Gene Editing Market Overview
Gene editing, genome editing, or genome engineering is a type of genetic engineering in which the gene of a particular organism is modified, added, or deleted for treatment of particular diseases. Early methods of gene editing have led to the insertion of the genome sequence within the cell such as homologous recombination. The global gene editing market report compiled by Market Research Future (MRFR) takes a look at various methods and its future potential for the period of 2018 to 2023 (forecast period).
The global gene editing market is predicted to expand at 18.30% CAGR during the forecast period. It can thrive by modifying the DNA of livestock to increase their immunity or defenses against certain bacteria. Gene-editing therapies on animals and their approval from regulatory bodies can bode well for the market. Furthermore, prevalence of cancer, hemophilia, HIV, and sickle cell anemia will drive the demand in the global market.
Applications in pet breeding, allergy-free foods, biodiesel, and others can drive the technological usage of CRISPR-Cas9. The use of gene editing techniques to remove mutations in DNA of companion animals and improve their overall health will be lucrative for manufacturers in the coming years. Prevalence of lactose intolerance and celiac disease is bound to spur the need for such technologies and drive the production of allergen-free foods.
Request a Free Sample Copy at: https://www.marketresearchfuture.com/sample_request/707
Strict regulations pertaining to the technology and adverse public perception may restrain the global gene editing market growth.
Gene Editing Market Segmentation
The global gene editing market is segmented on basis of methods, applications, and end users.
Based on methods, the gene editing market is segmented as Antisense technology, ZFN, CRISPR, TALEN, and others.
On the basis of application, the gene editing market segmented as gene therapy, plant genetic engineering, animal genetic engineering, and microorganism's genetic engineering.
On the basis of end users, the market is segmented into contract research organizations, biotechnology, and pharmaceuticals.
Gene Editing Market Regional Analysis
On the regional basis, the gene editing market is segmented into Americas, Europe, Asia Pacific (APAC), and Middle East and Africa (MEA).
The Americas are predicted to dominate the market owing to developments in drug discovery, investments in drugs and vaccines, rise in research studies, and mushrooming of the biotechnology sector. The increase in research expenditure, incidence of chronic diseases, and use of stem cells are major drivers of the market. The U.S., in particular, will drive the market growth till 2023. Sale of do-it-yourself (DIY) genetic engineering kits can lead to research at home and create interest among budding scientists. However, the ban on the sale of such kits may hamper its growth.
APAC, on the other hand, is likely to display the fastest growth rate during the forecast period owing to funds invested in public research organizations to further research in biotechnology. Establishment of gene editing companies and increased spending on research and development can fuel the market growth. Production of generic drugs and presence of contract research organizations will bode well for the global gene editing market.
Gene Editing Market Competition Outlook
Horizon Discovery Group plc, New England Biolabs, Inc., Sangamo Biosciences, Inc., Lonza Group Ltd., OriGene Technologies, Inc., Thermo Fisher Scientific, Inc., Transposagen Biopharmaceuticals, Inc., GenScript USA Inc., Integrated DNA Technologies, Inc., and Sigma-Aldrich Corporation are premier biotechnology companies in the global gene editing market. Sharing of technology, mergers and acquisitions, and partnerships are on the rise in the market. Recently, Horizon Discovery Group has decided to share a customized version of the CRISPR technology with its partners for the development of cell therapies.
Gene Editing Industry News
The Wyss Institute for Biologically Inspired Engineering at Harvard University and Cytosurge AG have decided to collaborate on introducing multiple edits of the DNA of single cells in CRISPR technology. This can drive forward the applications of cell lines in biopharmaceutical, pharmaceutical, and clinical sectors.
scope of study
assumptions & limitations
2 research methodology
macroeconomic indicators
TOC Continue………………….
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NOTE: Our team of researchers are studying Covid19 and its impact on various industry verticals and wherever required we will be considering covid19 footprints for a better analysis of markets and industries. Cordially get in touch for more details.
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At Market Research Future (MRFR), we enable our customers to unravel the complexity of various industries through our Cooked Research Report (CRR), Half-Cooked Research Reports (HCRR), & Consulting Services. MRFR team have supreme objective to provide the optimum quality market research and intelligence services to our clients.
Akash Anand
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redpajama_set_name: RedPajamaCommonCrawl


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VINOD KHOSLA
Chip Somodevilla / Getty
OCCUPATION: Co-founder of Sun Microsystems, biofuel venture capitalist
PRO: His massive, vanguard investment in green tech pushed former partners at leading venture capital firm Kleiner Perkins Caufield & Byers to invest more than $270 million in the sector and hire Nobel Prize–winner Al Gore as an active partner.
CON: A team from Brazil's Labor Ministry found "degrading" living conditions for 133 sugarcane workers employed by Brenco, an ethanol company whose investors include former President Clinton — and Khosla.
Next KRISTIN HALVORSEN


System Center 2012 Configuration Manager uses site system roles to support operations at each site. Computers that host the Configuration Manager site are named site servers, and computers that host the other site system roles are named site system servers. The site server is also a site system server.
Site system servers within the same site communicate with each other by using server message block (SMB), HTTP, or HTTPS, depending on the site configuration selections that you make. Because these communications are unmanaged and can occur at any time without network bandwidth control, review your available network bandwidth before you install site system servers and configure the site system roles.
At each site, you can install available site system roles on the site server or install one or more site system roles on another site system server. Configuration Manager does not limit the number of site system roles that you can run on a single site system server. However, Configuration Manager does not support site system roles from different sites on the same site system server. Additionally, Configuration Manager supports some site system roles only at specific sites in a hierarchy, and some site system roles have other limitations as to where and when you can install them.
Configuration Manager uses the Site System Installation Account to install site system roles. You specify this account when you run the applicable wizard to create a new site system server or add site system roles to an existing site system server. By default, this account is the local system account of the site server computer, but you can specify a domain user account for use as the Site System Installation Account. For more information about this account, see the Site System Installation Account in the Technical Reference for Accounts Used in Configuration Manager topic.
With Configuration Manager SP1, you can configure a proxy server on each site system server for use by all site system roles installed on that computer. This is not a new site system role, but a configuration for site system server computers.
There is a new site system role, the certificate registration point. This new site system role requires IIS and works in conjunction with a policy module plugin for the Network Device Enrollment Service server role for Active Directory Domain Services that runs on Windows Server 2012 R2. This solution provides certificate enrollment for devices that Configuration Manager manages.
For more information, see Introduction to Certificate Profiles in Configuration Manager in the Assets and Compliance in System Center 2012 Configuration Manager guide.
When you install a site, several site system roles automatically are installed on the servers that you specify during Setup. After a site is installed, you can install additional site system roles on those servers or on additional computers that you decide to use as site system servers. The following sections identify the default site system roles and the optional site system roles that are available in Configuration Manager.
When you install a Configuration Manager site, several default site system roles are automatically installed for the site. These site system roles are required for the core operation of each site and although some default site system roles can be moved to other servers, they cannot be removed from the site. Additionally, some default site system roles are installed on additional site system servers when you install optional site system roles.
The default site system roles are described in the following table.
The site server role is automatically installed on the server from which you run Configuration Manager Setup when you install a central administration site or primary site. When you install a secondary site, the site server role is installed on the server that you specify as the secondary site server.
Site systems are computers that provide Configuration Manager functionality to a site. Each site system hosts one or more site system roles. Most site system roles are optional, and you install them only if you have to use them for specific management tasks. Other site system roles are automatically installed on a site system and cannot be configured.
This role is assigned during Configuration Manager site installation or when you add an optional site system role to another server.
Any site system that runs the SMS Executive service also installs the component site system role.
This role is required to support other roles, such as a management point, and it is installed and removed with the other site system roles.
This role is always assigned to the site server when you install Configuration Manager.
The site database server is a computer that runs a supported version of Microsoft SQL Server, and it stores information for Configuration Manager sites, such as discovery data, hardware and software inventory data, and configuration and status information.
Each site in the Configuration Manager hierarchy contains a site database and a server that is assigned the site database server role. You can install SQL Server on the site server, or you can reduce the CPU usage of the site server when you install SQL Server on a computer other than the site server. Secondary sites can use SQL Server Express instead of a full SQL Server installation.
The site database can be installed on the default instance of SQL Server or on a named instance on a single computer that is running SQL Server. It can be installed on a named instance on a SQL Server cluster.
Typically, a site system server supports site systems roles from a single Configuration Manager site only; however, you can use different instances of SQL Server on clustered or non-clustered servers running SQL Server to host the database for different Configuration Manager sites. For this configuration, you must configure each instance of SQL Server to use different ports.
This role is installed when you install Configuration Manager.
The SMS Provider is the interface between the Configuration Manager console and the site database. This role is installed when you install a central administration site or primary site. Secondary sites do not install the SMS Provider. You can install the SMS Provider on the site server, the site database server (unless the site database is hosted on a clustered instance of SQL Server), or on another computer. You can also move the SMS Provider to another computer after the site is installed, or install multiple SMS Providers on additional computers. To move or install additional SMS Providers for a site, run Configuration Manager Setup, select the option Perform site maintenance or reset the Site, click Next , and then on the Site Maintenance page, select the option Modify SMS Provider configuration.
The SMS Provider is only supported on computers that are in the same domain as the site server.
Optional site system roles are site system roles that are not required for the core operation of a Configuration Manager site. However, by default, the management point and distribution point, which are optional site system roles, are installed on the site server when you install a primary or secondary site. Although these two site system roles are not required for the core operation of the site, you must have at least one management point to support clients at those locations. After you install a site, you can move the default location of the management point or distribution point to another server, install additional instances of each site system role, and install other optional site system roles to meet your business requirements.
The optional site system roles are described in the following table.
A site system role that provides software information to the Application Catalog website from the Software Library.
A site system role that provides users with a list of available software from the Application Catalog.
A site system role that connects to Microsoft to download Asset Intelligence catalog information and upload uncategorized titles so that they can be considered for future inclusion in the catalog. This site system role can only be installed on the central administration site or a stand-alone primary site. For more information about planning for Asset Intelligence, see Prerequisites for Asset Intelligence in Configuration Manager.
A site system role that communicates with a server that runs the Network Device Enrollment Service to manage device certificate requests that use the Simple Certificate Enrollment Protocol (SCEP).
The certificate registration point must not be installed on the same server that runs the Network Device Enrollment Service.
A site system role that contains source files for clients to download, such as application content, software packages, software updates, operating system images, and boot images. You can control content distribution by using bandwidth, throttling, and scheduling options. For more information, see Planning for Content Management in Configuration Manager.
A site system role that helps you monitor client installation and identify the clients that are unmanaged because they cannot communicate with their management point.
A site system role that provides policy and service location information to clients and receives configuration data from clients.
You must install at least one management point at each primary site that manages clients, and at each secondary site where you want to provide a local point of contact for clients to obtain computer and user polices.
A site system role that Configuration Manager uses to accept the Endpoint Protection license terms and to configure the default membership for Microsoft Active Protection Service.
A site system role that manages Configuration Manager enrollment requests from mobile devices and Mac computers.
A site system role that provisions and configures Intel AMT-based computers for out of band management.
A site system role that integrates with SQL Server Reporting Services to create and manage reports for Configuration Manager. For more information, see Planning for Reporting in Configuration Manager.
A site system role that integrates with Windows Server Update Services (WSUS) to provide software updates to Configuration Manager clients. For more information, see Planning for Software Updates in Configuration Manager.
A site system role that stores user state data when a computer is migrated to a new operating system. For more information about storing user state when you deploy an operating system, see How to Manage the User State in Configuration Manager.
A site system role that validates Configuration Manager Network Access Protection (NAP) policies. It must be installed on a NAP health policy server.
A site system role that was introduced in Configuration Manager SP1 that uses Microsoft Intune to manage mobile devices in the Configuration Manager console.
During normal operation, several Configuration Manager site system roles require connections to the Internet. Typically, this connection is made in the system context of the computer where the site system role is installed and cannot use a proxy configuration for typical user accounts. When a proxy server is required to complete a connection to the Internet, you must configure the computer to use a proxy server. For Configuration Manager with no service pack, you must manually configure the proxy server for the system context outside of Configuration Manager. Beginning with Configuration Manager SP1, you can use the Configuration Manager console to configure each site system server to use a proxy server. This proxy server configuration is used by each applicable site system role that is installed on that computer. For example, a software update point might connect to Microsoft to download updates, and with Configuration Manager SP1 when you use a cloud-based distribution point, the primary site server that manages the cloud-based distribution point must connect to Windows Azure.
This site system role connects to Microsoft and will use a proxy server configuration on the computer that hosts the Asset Intelligence synchronization point.
When you use a cloud-based distribution point, the primary site that manages the cloud-based distribution point must be able to connect to Windows Azure to provision, monitor, and distribute content to the distribution point.
If a proxy server is required for this connection, you must configure the proxy server on the primary site server. You cannot configure a proxy server on the cloud-based-distribution point in Windows Azure.
For more information see the Configure Proxy Settings for Primary Sites that Manage Cloud Services section in the Install and Configure Site System Roles for Configuration Manager topic.
This site system role connects to an Exchange Server and will use a proxy server configuration on the computer that hosts the Exchange Server connector.
This site system role can require connections to Microsoft Update to download patches and synchronize information about updates. With Configuration Manager with no service pack you can configure proxy server settings for the active software update point. With Configuration Manager SP1, proxy server options are only available for the software update point when there is already a proxy configured for the site system server.
For more information about proxy servers for software update points, see the Proxy Server Settings section in the Configuring Software Updates in Configuration Manager topic.
This site system role connects to Microsoft Intune and will use a proxy server configuration on the computer that hosts the Microsoft Intune connector.
Beginning with Configuration Manager SP1 you can configure the proxy server for a site system server when you install a site system role by using the Add Site System Roles Wizard or the Create Site System Server Wizard. After you have installed a site system server, you can configure a proxy server by editing the properties for the site system server. Each site system server supports only a single proxy server configuration. If you configure a new proxy server when you install site system role or edit the site system server properties, the new proxy server configuration replaces the previously configured proxy server for that site system server.
The proxy server configuration is shared by all site system roles that run on a computer. There is no support for individual site system roles that run on the same computer to use different proxy server configurations. If you require different site system roles to use different proxy servers, you must install the site system roles on different site system server computers.
A proxy server must be configured on the site system server that hosts the software update point before you can select either option. The proxy server is only used for the specific options you select.
Because each site system server supports a single proxy server configuration, if you add a new site system role to a computer and specify a different proxy server configuration than is already configured, the new replaces the previous proxy server configuration. Similarly, after you configure a proxy server for a site system server, if you edit the properties of the site system and change the proxy server configuration, this new configuration replaces the previous proxy server configuration.
For procedures about configuring the proxy server for site system roles, see the Install and Configure Site System Roles for Configuration Manager topic.
Before you install site system roles, identify the site types that can or cannot support specific site system roles, and how many instances of each site system role you can install at a site or across a hierarchy.
You can install some site system roles at only the top-level site in a hierarchy. A top-level site can be a central administration site of a multi-primary site hierarchy or a stand-alone primary site if your hierarchy consists of a single primary site with one or more secondary child sites.
Additionally, some site system roles support only a single instance per hierarchy. However, most site system roles support multiple instances across the hierarchy and at individual sites.
Use the following table to identify the site system roles that you can install at each type of site in a System Center 2012 Configuration Manager hierarchy, and whether the site system role provides functionality for its site only, or for the entire hierarchy. You can install any supported site system role on the site server computer or on a remote site system server at a central administration site or primary site. At a secondary site, only the distribution point is supported on a remote site system server.
1 Configuration Manager supports only a single instance of this site system role in a hierarchy.
2 By default, when you install a secondary site, a management point and a distribution point are installed on the secondary site server.
3 This role is required to support clients in Configuration Manager. Secondary sites do not support more than one management point and this management point cannot support mobile devices that are enrolled by Configuration Manager. For more information about the site system roles that support clients in Configuration Manager, see Determine the Site System Roles for Client Deployment in Configuration Manager.
4 When your hierarchy contains a central administration site, install a software update point at this site that synchronizes with Windows Server Update Services (WSUS) before you install a software update point at any child primary site. When you install software update points at a child primary site, configure it to synchronize with the software update point at the central administration site.
5 Prior to System Center 2012 R2 Configuration Manager, all site system roles at a secondary site must be located on the site server computer. The only exception is the distribution point. Secondary sites support installing distribution points on the site server computer and on remote computers. Beginning with System Center 2012 R2 Configuration Manager, the state migration point can also be installed on the site server computer or on a remote computer, and can be co-located with a distribution point.
Use the following table to help you decide where to install the site system roles.
When the Application Catalog supports client computers on the Internet, as a security best practice, install the Application Catalog website point in a perimeter network and the Application Catalog web service point on the intranet.
Configuration Manager supports a single instance of this site system role in a hierarchy and only at the top-level site in the hierarchy.
Configuration Manager supports multiple instances of this site system role at each primary site or central administration site. In this scenario, clients are non-deterministically assigned to one of the certificate registration points, to help load balance certificate requests. However, a single certificate registration point can provide functionality to an entire hierarchy.
Each certificate registration point requires access to a separate instance of a Network Device Enrollment Service. You cannot configure two or more certificate registration points to use the same Network Device Enrollment Service.
If a user enrolls mobile devices by using Configuration Manager and their Active Directory account is in a forest that is untrusted by the site server's forest, you must install an enrollment point in the user's forest so that the user can be authenticated.
When you support mobile devices on the Internet, as a security best practice, install the enrollment proxy point in a perimeter network and the enrollment point on the intranet.
If you install clients by using client push installation, the first fallback status point that is installed for the site is automatically assigned to clients.
If you have two fallback status points in the site so that one fallback status point accepts client connections from the Internet (for example, it is in a perimeter network), and the other fallback status point accepts client connections on the intranet only, assign the Internet-based clients to the Internet-based fallback status point.
You cannot install a System Center 2012 Configuration Manager management point on a server that has a Configuration Manager 2007 client installed. You must first uninstall the Configuration Manager 2007 client.
Install this site system to support out of band management for Intel AMT-based computers. In Configuration Manager, this site system must be installed in a primary site that also contains the enrollment point.
The out of band service point cannot provision AMT-based computers in a different forest.
Install this site system in the central administration site to synchronize with Windows Server Update Services and in all primary sites that use the Software Updates feature. Also consider installing a software update point in secondary sites when data transfer across the network is slow.
Install this site system role in either a primary site or a secondary site. Consider installing a state migration point in secondary sites when data transfer across the network is slow.
Install this site system role in the central administration site and at any primary site.
A reporting services point installed in a primary site rather than a central administration site can display data from that primary site only.
Install this site system role in primary sites and secondary sites to distribute software to clients by using Background Intelligent Transfer Service (BITS), Windows BranchCache, multicast for operating system deployment, and streaming for application virtualization.
When the distribution point is offline or in sleep mode from a power management policy, for example, software deployments might fail.
The site database server is a computer that runs a supported version of Microsoft SQL Server that stores information for Configuration Manager sites. Each site in a System Center 2012 Configuration Manager hierarchy contains a site database and a server that is assigned the site database server role. For central administration sites and primary sites, you can install SQL Server on the site server, or you can install SQL Server on a computer other than the site server. For secondary sites, you can use SQL Server Express instead of a full SQL Server installation; however, the database server must be co-located with the site server.
You can install the site database on the default instance of SQL Server, a named instance on a single computer running SQL Server, or on a named instance on a clustered instance of SQL Server.
Typically, a site system server supports site system roles from only a single Configuration Manager site; however, you can use different instances of SQL Server, on clustered or non-clustered servers running SQL Server, to host a database from different Configuration Manager sites. To support databases from different sites, you must configure each instance of SQL Server to use unique ports for communication.
To successfully configure a SQL Server installation for use as a Configuration Manager site database server, ensure that the following required SQL Server configurations are specified. Also, be familiar with the optional configurations and planning for service principal names (SPNs), database server location planning, and how to modify the database configuration after a site has completed installation.
Before you specify a computer to host the site database for any site, ensure that it meets the prerequisites for database servers. Before installing SQL Server, you must be familiar with the Configurations for the SQL Server Site Database section of the Supported Configurations for Configuration Manager topic.
At a central administration site and at primary sites, you can co-locate the database server on the site server, or place it on a remote server. At secondary sites, the database server is always co-located on the secondary site server.
If you use a remote database server computer, ensure the intervening network connection is a high-availability, high-bandwidth network connection. This is because the site server and some site system roles must constantly communicate with the SQL Server that is hosting the site database.
The amount of bandwidth required for communications to the database server depends upon a combination of many different site and client configurations; therefore, the actual bandwidth required cannot be adequately predicted.
Each computer that runs the SMS Provider and that connects to the site database increases network bandwidth requirements.
The computer that runs SQL Server must be located in a domain that has a two-way trust with the site server and all computers running the SMS Provider.
You cannot use a clustered SQL Server for the site database server when the site database is co-located with the site server.
A Service Principal Name (SPN) for the Configuration Manager site database server must be registered in Active Directory Domain Services for the SQL Server service account. The registered SPN lets SQL clients identify and authenticate the service by using Kerberos authentication.
When you configure SQL Server to use the local system account to run SQL Server services, the SPN is automatically created in Active Directory Domain Services. When a local domain user account is in use, you must manually register the SPN for the account. Without registering the SPN for the SQL Server service account, SQL clients and other site systems are not able to perform Kerberos authentication, and communication to the database might fail.
Running the SQL Server service by using the local system account of the computer running SQL Server is not a SQL Server best practice. For the most secure operation of SQL Server site database servers, configure a low-rights domain user account to run the SQL Server service.
For information about how to register the SPN when you use a domain user account, see How to Manage the SPN for SQL Server Site Database Servers in this documentation library.
After you install a site, you can manage the configuration of the site database and site database server by running Setup on a central administration site server or primary site server. It is not supported to manage the database configuration for a secondary site.
For more information about modifying the site database configuration, see Modify the Site Database Configuration in this documentation library.
By default, Configuration Manager generates alerts when free disk space on a site database server is low. The defaults are set to generate a warning when there is 10 GB or less of free disk space, and a critical alert when there is 5 GB or less of free disk space. You can modify these values or disable alerts for each site.
In the Administration workspace, expand Site Configuration, and then click Sites.
Select the site that you want to configure and open that site's Properties.
In the site's Properties dialog box, select the Alert tab, and then edit the settings.
Click OK to close the site properties dialog box.
The SMS Provider is a Windows Management Instrumentation (WMI) provider that assigns read and write access to the Configuration Manager database at a site. The SMS Admins group provides access to the SMS Provider and Configuration Manager automatically creates this security group on the site server and on each SMS Provider computer. You must have at least one SMS Provider in each central administration site and primary site. These sites also support the installation of additional SMS Providers. Secondary sites do not install the SMS Provider.
The Configuration Manager console, Resource Explorer, tools, and custom scripts use the SMS Provider so that Configuration Manager administrative users can access information that is stored in the database. The SMS Provider does not interact with Configuration Manager clients. When a Configuration Manager console connects to a site, the Configuration Manager console queries WMI on the site server to locate an instance of the SMS Provider to use.
The SMS Provider helps enforce Configuration Manager security. It returns only the information that the administrative user who is running the Configuration Manager console is authorized to view.
When each computer that holds an SMS Provider for a site is offline, Configuration Manager consoles cannot connect to that site's database.
Use the following sections in this topic to plan for the SMS Provider. For information about how to manage the SMS Provider, see Manage the SMS Provider Configuration for a Site.
The computer must be in a domain that has a two-way trust with the site server and the site database site systems.
The computer cannot have a site system role from a different site.
The computer cannot have an SMS Provider from any site.
The computer must run an operating system that is supported for a site server.
The computer must have at least 650 MB of free disk space to support the Windows Automated Installation Kit (Windows AIK) components that are installed with the SMS Provider. For more information about Windows AIK and the SMS Provider, see the Operating System Deployment Requirements for the SMS Provider section in this topic.
Beginning with Configuration Manager SP1, the Windows ADK replaces the Windows AIK. For more information, see Prerequisites For Deploying Operating Systems in Configuration Manager topic in the Deploying Software and Operating Systems in System Center 2012 Configuration Manager guide.
Each SMS Provider supports simultaneous connections from multiple requests. The only limitations on these connections are the number of server connections that are available on the SMS Provider computer, and the available resources on the SMS Provider computer to service the connection requests.
After a site is installed, you can run Setup on the site server again to change the location of an existing SMS Provider, or to install additional SMS Providers at that site. You can install only one SMS Provider on a computer, and a computer cannot install an SMS Provider from more than one site.
Use the following table to identify the advantages and disadvantages of installing an SMS Provider on each supported location.
The SMS Provider does not use the system resources of the site database computer.
This location can provide better performance than an SMS Provider located on a computer other than the site server or site database computer.
The SMS Provider uses system and network resources that could be dedicated to site server operations.
The SMS Provider does not use site system resources on the site server.
This location can provide the best performance of the three locations, if sufficient server resources are available.
The SMS Provider uses system and network resources that could be dedicated to site database operations.
This location is not an option when the site database is hosted on a clustered instance of SQL Server.
SMS Provider does not use site server or site database computer resources.
This type of location lets you deploy additional SMS Providers to provide high availability for connections.
The SMS Provider performance might be reduced due to the additional network traffic that is required to coordinate with the site server and the site database computer.
This server must be always accessible to the site database computer and all computers with the Configuration Manager console installed.
This location can use system resources that would otherwise be dedicated to other services.
To view the locations of each SMS Provider that is installed at a site, view the General tab of the site Properties dialog box.
The SMS Provider operates independently of the display language of the computer where it is installed.
When an administrative user or Configuration Manager process requests data by using the SMS Provider, the SMS Provider attempts to return that data in a format that matches the operating system language of the requesting computer. The SMS Provider does not translate information from one language to another. Instead, when data is returned for display in the Configuration Manager console, the display language of the data depends on the source of the object and type of storage.
Objects that Configuration Manager creates are stored in the database by using support for multiple languages. The object is stored by using the languages that are configured at the site where the object is created when you run Setup. These objects are displayed in the Configuration Manager console in the display language of the requesting computer, when that language is available for the object. If the object cannot be displayed in the display language of the requesting computer, it is displayed in the default language, which is English.
Objects that an administrative user creates are stored in the database by using the language that was used to create the object. These objects display in the Configuration Manager console in this same language. They cannot be translated by the SMS Provider and do not have multiple language options.
You will have a large number of administrative users that run a Configuration Manager console and connect to a site at the same time.
You will use the Configuration Manager SDK, or other products, that might introduce frequent calls to the SMS Provider.
You want to ensure high availability for the SMS Provider.
When multiple SMS Providers are installed at a site and a connection request is made, the site non-deterministically assigns each new connection request to use an installed SMS Provider. You cannot specify the SMS Provider location to use with a specific connection session.
Consider the advantages and disadvantages of each SMS Provider location and balance these considerations with the information that you cannot control which SMS Provider will be used for each new connection.
For example, when you first connect a Configuration Manager console to a site, the connection queries WMI on the site server to non-deterministically identify an instance of the SMS Provider that the console will use. This specific instance of the SMS Provider remains in use by the Configuration Manager console until the Configuration Manager console session ends. If the session ends because the SMS Provider computer becomes unavailable on the network, when you reconnect the Configuration Manager console the site will non-deterministically assign an SMS Provider computer to the new connection session. It is possible to be assigned to same SMS Provider computer that is not available. If this occurs, you can attempt to reconnect the Configuration Manager console until an available SMS Provider computer is assigned.
When the computer is a member server, the SMS Admins group is created as a local group.
When the computer is a domain controller, the SMS Admins group is created as a domain local group.
When the SMS Provider is uninstalled from a computer, the SMS Admins group is not removed from the computer.
Before a user can make a successful connection to an SMS Provider, their user account must be a member of the SMS Admins group. Each administrative user that you configure in the Configuration Manager console is automatically added to the SMS Admins group on each site server and to each SMS Provider computer in the hierarchy. When you delete an administrative user from the Configuration Manager console, that user is removed from the SMS Admins group on each site server and on each SMS Provider computer in the hierarchy.
After a user makes a successful connection to the SMS Provider, role-based administration determines what Configuration Manager resources that user can access or manage.
You can view and configure SMS Admins group rights and permissions by using the WMI Control MMC snap-in. By default, Everyone has Execute Methods, Provider Write, and Enable Account permissions. After a user connects to the SMS Provider, that user is granted access to data in the site database based on their role-based administrative security rights as defined in the Configuration Manager console. The SMS Admins group is explicitly granted Enable Account and Remote Enable on the Root\SMS namespace.
Each administrative user who uses a remote Configuration Manager console requires Remote Activation DCOM permissions on the site server computer and on the SMS Provider computer. Although you can grant these rights to any user or group, as best practice, grant them to the SMS Admins group to simplify administration. For more information, see the Configure DCOM Permissions for Remote Configuration Manager Console Connections section in the Manage Site and Hierarchy Configurations topic.
The structure of the SMS Provider is defined by the WMI schema. Schema namespaces describe the location of Configuration Manager data within the SMS Provider schema. The following table contains some of the common namespaces that are used by the SMS Provider.
The SMS Provider, which is extensively used by the Configuration Manager console, Resource Explorer, Configuration Manager tools, and scripts.
Provides the location of the SMS Provider computers for a site.
Location inventoried for WMI namespace information during hardware and software inventory.
Configuration Manager client configuration policies and client data.
Location of inventory reporting classes that are collected by the inventory client agent. These settings are compiled by clients during computer policy evaluation and are based on the client settings configuration for the computer.
For Configuration Manager with no service pack, the Windows AIK installs as a component of the SMS Provider. Beginning with Configuration Manager with SP1, you must manually install the Windows ADK on a computer before you can install the SMS Provider.
The Windows AIK or Windows ADK installation can require up to 650 MB of free disk space on each computer that installs the SMS Provider. This high disk space requirement is necessary for Configuration Manager to install the Windows PE boot images.
Configuration Manager site system roles that require Microsoft Internet Information Services (IIS) also require a website to host the site system services. By default, site systems use the IIS website named Default Web Site on a site system server. However, you can use a custom website that has the name of SMSWEB. This option might be appropriate if you must run other web applications on the same server and their settings are either incompatible with Configuration Manager, or you want the additional resilience of using a separate website. In this scenario, these other applications continue to use the default IIS website, and Configuration Manager operations use the custom website.
When you run other applications on a Configuration Manager site system, you increase the attack surface on that site system. As a security best practice, dedicate a server for the Configuration Manager site systems that require IIS.
You can use custom websites on all primary sites. When you use a custom website at a site, all client communications within the site are directed to use the custom website named SMSWEB on each site system instead of the default website on IIS. Additionally, site system roles that use IIS but do not accept client connections, such as the reporting services point, also use the SMSWEB website instead of the default website. For more information about which site systems require IIS, see Supported Configurations for Configuration Manager.
Before you configure a Configuration Manager site to use a custom website, you must manually create the custom website in IIS on each site system server that requires Internet Information Services (IIS) at that site. Because secondary sites are automatically configured to use a custom website when you enable this option on the parent site, you must also create a custom website in IIS on each secondary site system server that requires IIS.
If you enable custom websites for one site, consider using custom websites for all sites in your hierarchy to ensure that clients can successfully roam within the hierarchy.
When you create a custom website, you must assign port numbers to the custom website that differ from the port numbers that the default website uses. The default website and the custom website cannot run at the same time if both sites are configured to use the same TCP/IP ports.
After the site system roles are reinstalled, verify that the TCP/IP ports configured in IIS for the custom website match the client request ports for the site.
For information about how to configure ports for client communication, see How to Configure Client Communication Port Numbers in Configuration Manager.
Although you can select or clear the check box to use a custom website at any time, if possible, configure this option as soon as the site is installed to minimize any disruptions to service continuity. When you make this site configuration change, plan for the site system roles that are automatically uninstalled and reinstalled with the new website and port configuration. You must also plan to manually uninstall and reinstall any site system roles that are not automatically reinstalled to use the new website and port configuration.
When you change from using the default website to use a custom website, Configuration Manager does not automatically remove the old virtual directories. If you want to remove the files that Configuration Manager used, you must manually delete the virtual directories that were created under the default website.
If you change the site option to use a custom website, clients that are assigned to the site must be configured to use the client request port that matches the new website port. For information about how to configure ports for client communication, see How to Configure Client Communication Port Numbers in Configuration Manager.
Create the custom web site in IIS for each site system server that requires IIS in the primary site and any child secondary sites.
Name the custom website SMSWEB.
Configure the custom website to respond to the same port that you configure for Configuration Manager client communication.
For each custom website or default website that uses a custom folder, place a copy of the default document type that you use into the root folder that hosts the website. For example, on a Windows Server 2008 R2 computer with default configurations, iisstart.htm is one of several default document types available. You can find this file in the root of the default website, and then place a copy of this file (or a copy of the default document type you use) into the root folder that hosts the SMSWEB custom website. For more information about default document types, see Default Document <defaultDocument> for IIS.
When you change from using the default website and use a custom website, Configuration Manager adds the client request ports that are configured on the default website to the custom website. Configuration Manager does not remove these ports from the default website, and the ports are listed for both the default and custom website. IIS cannot start both websites when they are configured to operate on the same TCP/IP ports, and clients cannot contact the management point.
Use the information in the following procedures to help you configure the custom websites in IIS.
The following procedures are for Internet Information Services (IIS) 7.0 on Windows Server 2008 R2. If you cannot use these procedures because your server has a different operating system version, refer to the IIS documentation for your operating system version.
On the computer that runs the Configuration Manager site system, click Start, click Administrative Tools, and then click Internet Information Services (IIS) Manager.
In the Internet Information Services (IIS) Manager console, in the Connections pane, right-click the Sites node to select Add Web Site.
In the Add Web Site dialog box, enter SMSWEB in the Site name box.
SMSWEB is the required name for Configuration Manager custom websites.
In the Physical path box, specify the physical path to use for the website folder.
Specify the protocol and custom port for this website.
- After you create the website, you can edit it to add additional website bindings for additional protocols.
- When you configure the **HTTPS** protocol, you must specify a **SSL certificate** before you can save the configuration.
Click OK to create the custom website.
Place a copy of the default document type you use into the root folder that hosts the custom website.
In the Internet Information Services (IIS) Manager, edit the Bindings of the IIS website that has the duplicate ports (Default Web Site). Remove the ports that match the ports that are assigned to the custom website (SMSWEB).
Restart the SMS_SITE_COMPONENT_MANAGER service on the site server.


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Posted on December 9, 2021 by Paul Mirengoff in 2020 Presidential Election, Freedom, January 6, Media Bias
Dems investigate funder of election protest rally
Julie Fancelli, the subject of a Washington Post drive-by attack, has contributed millions of dollars to charity through a family foundation. She also contributes generously to conservative political candidates.
In late December of last year, she made substantial contributions to groups sponsoring and promoting the January 6 protest rally in Washington, D.C. The money apparently was used to pay travel and hotel expenses for some of the pro-Trump protesters.
Fancelli had said she did not want Trump to "step down" from the presidency and wanted Congress to overturn Joe Biden's election victory. However, she also says she didn't expect the January 6 protest to turn violent and does not support the violence that occurred.
The Washington Post's lengthy hit piece on Fancelli provides no reason for disbelieving her. Nor am I aware of any.
Yet, Fancelli is under attack by House Democrats for her financial contributions in furtherance of the protest. Rep. Bennie Thompson, chairman of the committee investigating the events of January 6, says he believes that Fancelli "played a strong role" in helping to finance" the rally. The Mississippi partisan adds, "we're trying to follow the money."
But why? Fancelli had every right to contribute money to protesters.
The protests were misguided and, in my view, sought the wrong result given the vote counts and the disposition of challenges thereto. So what? Americans have a constitutional right to protest on behalf of misguided causes that seek wrong results. Left-wingers do it all the time.
Similarly, Americans have the right to support misguided protests financially, without having to worry about being investigated by Congress. If not, we no longer live in a free country.
Kamala Harris promoted a fund that bailed out BLM protesters after they had engaged in unlawful conduct. One of them was charged with attempted murder for shooting at police officers. Another was charged with looting three different stores.
If Democrats are going to investigate Fancelli for supporting protesters before they did anything unlawful, maybe Republicans should investigate Harris if (as seems likely) they regain control of the House in January 2023.
It isn't just Bennie Thompson and his partisan crew that's trying to make trouble for Fancelli. The Washington Post is, as well.
And it's doing so disingenuously. The headline of its story about Fancelli is "Low-profile heiress who 'played a strong role' in financing Jan. 6 rally is thrust into spotlight."
But it's the Washington Post that's doing the "thrusting." Until the Post published its report, virtually no one knew that Fancelli is being investigated by Thompson's committee. Few had any idea who she is. Now readers of the Post's article know not only who Fancelli is, but which candidates she contributes money to and, indeed, a potted history of her adult life.
Moreover, the title of the print edition of the story says that Fancelli funded "Jan. 6," not the "Jan. 6 rally." The Post thus invited readers to believe she funded the violence that occurred that day. This is what people, especially readers of the Post, think of when they see "Jan. 6."
It's good that the Post provided a less misleading title in the internet version of the story. But it still misled those who read the paper edition.
More insidious is the premise of the Post's story — that there's something troubling, and maybe worthy of investigating, when someone contributes money to a protest rally. Any American who believes in freedom surely agrees with GOP fundraiser Caroline Wren. She told the Post:
The funding behind the First Amendment rally at the White House Ellipse was entirely lawful and consistent with the rights Ms. Fancelli has as an American citizen.
Unfortunately, this quotation does not appear until well into the Post's article. But it's all that needed to be said about the matter and, in fact, should really go without saying.


Social media firms that breach "responsibility of care" legal guidelines designed to maintain kids protected on-line might face prison investigation and limitless fines, below proposals because of be outlined by the NSPCC.
Corporations that don't introduce measures to guard kids from hurt comparable to sexual abuse, bullying and self-harm might be prosecuted for a breach of their responsibility of care, if laws prompt by the youngsters's charity is accepted into legislation.
Corporations should appoint named executives to be personally answerable for upholding responsibility of care, The Daily Telegraph reported. If they're discovered to be in breach of the foundations, they might be banned from directorial roles for as much as 15 years, in keeping with present disqualification guidelines.
The NSPCC's head of on-line youngster security Andy Burrows mentioned laws is required to maintain kids protected.
"Except we've regulation that's able to defending kids in the way in which we all know is critical, then we'll see additional tragedies with kids coming to hurt," he instructed the newspaper.
A brand new class of remedies for ladies going via the menopause is ready to scale back numbers of debilitating sizzling flushes by as a lot as three quarters in a matter of days, a trial has discovered.
Analysis from Oxford College discovered that multiple million further individuals affected by psychological well being issues would profit from being prescription drugs and criticised "ideological" causes docs use to keep away from doing so.
The household of a youngster who died from flu has urged individuals to not delay going to A&E if they're frightened about their signs. Melissa Whiteley, an 18-year-old engineering scholar from Hanford in Stoke-on-Trent, fell sick at Christmas and died in hospital a month later.
The Authorities has pledged to evaluation tens of 1000's of circumstances the place girls have been given dangerous vaginal mesh implants.
The NHS shall be requested to go additional to forestall the deaths of sufferers in its care as a part of a "zero suicide ambition" being launched right this moment.
Human trials have begun with a brand new most cancers remedy that may prime the immune system to eradicate tumours. The therapy, that works equally to a vaccine, is a mix of two current medication, of which tiny quantities are injected into the stable bulk of a tumour.
1000's of cervical most cancers screening outcomes are below evaluation after failings at a laboratory meant some girls had been incorrectly given the all-clear. Numerous girls have already been instructed to contact their docs following the identification of "procedural points" within the service supplied by Pathology First Laboratory.
Most breast most cancers sufferers don't die from their preliminary tumour, however from secondary malignant growths (metastases), the place most cancers cells are in a position to enter the blood and survive to invade new websites. Asparagine, a molecule named after asparagus the place it was first recognized in excessive portions, has now been proven to be a vital ingredient for tumour cells to achieve these migratory properties.
A report variety of nursing and midwifery positions are at present being marketed by the NHS, with greater than 34,000 positions at present vacant, in response to the newest knowledge. Demand for nurses was 19 per cent larger between July and September 2017 than the identical interval two years in the past.
CBD has a broadly reverse impact to delta-9-tetrahydrocannabinol (THC), the primary lively part in hashish and the substance that causes paranoia and anxiousness.
The paper discovered that there have been 45,000 extra deaths within the first 4 years of Tory-led efficiencies than would have been anticipated if funding had stayed at pre-election ranges.
On this trajectory that would rise to just about 200,000 extra deaths by the top of 2020, even with the additional funding that has been earmarked for public sector providers this yr.
Tobacco and alcohol firms might win extra simply in courtroom circumstances such because the latest battle over plain cigarette packaging if the EU Constitution of Elementary Rights is deserted, a barrister and public well being professor have mentioned.
New analysis has discovered that infants born to fathers below the age of 25 or over 51 are at larger threat of creating autism and different social problems. The research, performed by the Seaver Autism Heart for Analysis and Remedy at Mount Sinai, discovered that these kids are literally extra superior than their friends as infants, however then fall behind by the point they hit their teenage years.
Commuters who swap their automotive or bus go for a motorcycle might minimize their threat of creating coronary heart illness and most cancers by nearly half, new analysis suggests – however campaigners have warned there may be nonetheless an "pressing want" to enhance street situations for cyclists.
Biking to work is linked to a decrease threat of creating most cancers by 45 per cent and heart problems by 46 per cent, in response to a research of 1 / 4 of one million individuals.
Strolling to work additionally introduced well being advantages, the College of Glasgow researchers discovered, however to not the identical diploma as biking.
Vaping has been given an emphatic thumbs up by well being specialists after the primary long-term research of its results in ex-smokers.
Tens of millions of persons are placing themselves in danger by cooking their rice incorrectly, scientists have warned.
An injectable contraceptive gel that acts as a 'reversible vasectomy' is a step nearer to being provided to males following profitable trials on monkeys.
Girls who work at evening or do irregular shifts might expertise a decline in fertility, a brand new research has discovered.
The Japanese authorities has introduced measures to restrict the quantity of extra time workers can do – in an try to cease individuals actually working themselves to loss of life.
A fifth of Japan's workforce are prone to loss of life by overwork, often known as karoshi, as they work greater than 80 hours of extra time every month, in response to a authorities survey.
It's well-known that hypertension is a threat issue for dementia, so the outcomes of a brand new research from the College of California, Irvine, are fairly stunning. The researchers discovered that individuals who developed hypertension between the ages of 80-89 are much less more likely to develop Alzheimer's illness (the most typical type of dementia) over the subsequent three years than individuals of the identical age with regular blood stress.
Scientists in a brand new research present that the primary indicators of Parkinson's might be stopped. The UCL research continues to be in its analysis interval however the group are 'excited'. Right this moment's Parkinson's medication handle the signs of the illness however finally don't cease its development within the mind.
A brand new research exhibits that ingesting alcohol three to 4 days per week might scale back the chance of diabetes. Wine was discovered to be simplest in decreasing the chance because of the chemical compounds that stability blood sugar ranges.
Final week, Instagram introduced it will ban graphic pictures of self-harm from its platform after the daddy of a youngster who took her personal life mentioned the social community "helped kill my daughter".
Molly Russell died in 2017 aged 14. Her household discovered materials regarding despair and suicide after they checked out her Instagram account after her loss of life.
Well being Secretary Matt Hancock praised the photo-sharing service's determination however mentioned there may be "extra to do" to maintain the location protected.
Talking after a gathering with the app's bosses final week, Mr Hancock mentioned: "What occurred to Molly Russell is each father or mother's fashionable nightmare. I'm glad Instagram have dedicated to me that they may now take down graphic self-harm and suicide content material. I will maintain working to make the web protected for all.
The Samaritans function a round the clock freephone service 365 days a yr for individuals who need to speak in confidence. They are often contacted by cellphone on 116 123 or by visiting samaritans.org.


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NATIONAL SLALOM, GIANT SLALOM & TEAM EVENT TITLES AWARDED
Calgary, Alta. (March 24, 2018) – RED Mountain Resort and its volunteers continued to battle tough weather conditions for the 2018 Sport Chek National Championships. Snow dumped down all day for the men's slalom and ladies' giant slalom national championship races.
Valérie Grenier (Mont-Tremblant, Que.) defended her giant slalom national title for the second year in a row, winning by 0.10 and Erik Read (Calgary, Alta.) was named the men's slalom national champion for the third time in his career.
Grenier made up time on her second run after sitting in fourth-place after her first run. Grenier won the second run by .44 seconds.
"I'm happy I could make up time today and it was a nice surprise to be on the podium!" said Grenier.
Joining Grenier on the podium were fellow National Team athletes, Candace Crawford (Toronto, Ont.) and Erin Mielzynski (Collingwood, Ont.), making it the second podium in as many days for both Crawford and Mielzynski.
"It feels good to grab two podiums at Nationals in two days," said Crawford. "I would've liked to have caught Val [Grenier] but I know my skiing was there in the tough conditions. I'm happy with the way I skied and charged through the rough day. It was a good race to end the season on."
"It's pretty cool to stand on the podium in GS today without having skied that much volume this year," said Mielzynski. "I think every run here got better and better. The conditions were tough but everyone battled through and it was a lot of fun. It's great to be on the podium beside my teammates at Nationals and I'm really happy to be here."
Katie Fleckenstein (Green Mountain Valley School) is the U19 ladies' giant slalom champion. Joining her on the podium was Sydney Mason (Craigleith Ski Club) in second-place and Alyssa Hill (Team Panorama) in third-place.
"It was a little wild out there today," said Fleckenstein. "Both runs had low visibility and it was bumpy but I guess that's when I ski the best – it was fun! I love it out here getting to ski with all my friends. It's been great."
On the men's side, the Read brothers went one and two with older brother Erik Read finishing in first-place and Jeffrey Read (Calgary, Alta.) finishing 1.64 seconds back in second-place. Rounding out the men's slalom national podium was Jack (James) Crawford (Whistler, B.C./ Toronto, Ont.).
"We've had all sorts of weather in Rossland and today we had some snow thrown at us," said Erik Read. "Trevor [Philp] threw down a great first run so I knew I had to have a great second run to catch him. Unfortunately he went out but I'm really happy to be National Champ. I think the National Championships are really important in Canada so I'm super happy to have the title today. It's really great to be racing with some of the younger guys who are bringing new and great energy into ski racing."
"Racing Erik [Read] here is like the good old days chasing him down the track," said Jeffery Read. "It was great to have him as a pace-setter. It's always nicer when I beat him but I couldn't catch him today!"
Declan McCormack (Whistler Mountain Ski Club) was crowned the U19 men's slalom national champion. Asher Jordan (Whistler Mountain Ski Club) finished in second-place and Jamie Casselman (Team Panorama) finished in third-place.
"This is my first National Champs so it's really cool to be here," said McCormack. "It's really well put together and I'm happy to be here. I'm happy with how today went and it's been a great season."
The second annual National Championship Team Event race was also held today. It was stiff competition and heated battles against the provinces. Each provincial team selected one national team athlete, one Canada Ski cross athlete and two provincial and/or club-level athletes.
Alberta One Team took the top spot today. Made up of Erik Read, Abby McEwen, Georgia Burgess and Liam Wallace, the Albertans battled it out round after round to be victorious. Ontario One Team made up of Erin Mielzynski, Kevin Drury, Sydney Mason and Karl Kuus finished in second-place and Alberta Two Team made up of Jeffrey Read, Ashleigh Alexander, Cassidy Gray and Trent McCarthy, finished in third-place
Ladies' 2018 Sport Chek National Giant Slalom Championships Podium
1 – Valérie Grenier - CAN
2 – Candance Crawford – CAN
3 – Erin Mielzynski - CAN
Ladies' U19 2018 Sport Chek National Giant Slalom Championships Podium
1 – Katie Fleckenstein – Green Mountain Valley School
2 – Sydney Mason – Craigleith Ski Club
3 – Alyssa Hill – Team Panorama
Men's 2018 Sport Chek National Slalom Championships Podium
1 – Erik Read – CAN
2 – Jeff Read – CAN
3 – Jack (James) Crawford - CAN
Men's U19 2018 Sport Chek National Slalom Championships Podium
1 – Declan McCormack - Osler Bluff Ski Club
2 – Asher Jordan - Whistler Mountain Ski Club
3 – Jamie Casselman - Team Panorama
Team Event 2018 Sport Chek National Slalom Championships Podium
1 – Alberta One
2 – Ontario One
3- Alberta Two


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Archive for the 'Health Care Stocks' Category
Amylin Pharmaceuticals, Inc. (AMLN) soars on news of rejection of Bristol-Myers takeover bid
Shares of diabetes drug maker Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN) were up more than 50 percent from Tuesday's closing price in morning trading on Wednesday after Bloomberg reported that Amylin rebuffed an unsolicited takeover bid from pharma giant Bristol-Myers Squib Co. (NYSE: BMY) for $3.5 billion, or $22 a share.
According to data provided by Yahoo Finance, shares of AMLN touched a high of $23.50 on Wednesday, up from Tuesday's closing price of $15.39.
Reuters reported that Amylin has been considered a possible takeover target for quite some time. Spokeswomen for Bristol-Myers and Amylin refused to comment, Reuters reported.
"Bristol as an acquirer makes sense," Robyn Karnauskas, an analyst with Deutsche Bank in New York, wrote in a note to clients today, Bloomberg reported. "Amylin could be worth up to $31 a share based on expense synergies. However, Bristol is financially disciplined."
There have been 16 acquisitions more than $1 billion of biotech companies in Amylin's peer group in the past five years, according to data compiled by Bloomberg. The average disclosed size was $8 billion, with an average premium of 35 percent, the Bloomberg data show.
Tags: AMLN, Biotech Stocks, bmy, Deutsche Bank, mergers and acquisition
Posted in Health Care Stocks | 1 Comment »
Chelsea Therapeutics International Ltd. (CHTP) rises on FDA nod for Northera
Shares of Charlotte-based drug maker, Chelsea Therapeutics International Ltd. (Nasdaq: CHTP) were up as much as 69 percent from Thursday's closing price on Friday after it was announced that the U.S. Food and Drug Administration voted in favor of recommending Chelsea's neurological drug, Northera, for approval.
Chelsea Therapeutics shares touched a high of $4.09 on Friday, up from Thursday's closing price of $2.41.
"We believe our clinical data demonstrates the significant symptomatic benefit of Northera treatment across a broad range of Neurogenic OH symptoms," said Chelsea Therapeutics' CEO Dr. Simon Pedder in a statement. "Since no other treatment has been proven to alleviate the symptoms of neurogenic OH or improve patients' ability to carry out activities of daily living, we continue to believe Northera could fill this unmet need for patients with Parkinson's disease, MSA, PAF and other neurologic diseases. We are pleased by today's panel vote and we look forward to continuing to work with the FDA in advance of the March 28, 2012 PDUFA action date."
Northera is the lead investigational agent in Chelsea's pipeline, and has has been studied in two Phase III clinical trials for the treatment of symptomatic neurogenic orthostatic hypotension in patients with primary autonomic failure — a group of diseases that includes Parkinson's disease, multiple system atrophy (MSA) and pure autonomic failure (PAF). Droxidopa is a synthetic catecholamine that is directly converted to norepinephrine (NE) via decarboxylation, resulting in increased levels of NE in the nervous system, both centrally and peripherally.
Chlesea Therapeutics submitted a New Drug Application (NDA) for Northera in September 2011. The drug was previously granted Orphan Drug Designation, which is granted by the FDA to treatments for rare diseases and disorders.
Tags: CHTP, Penny Stocks
Posted in Health Care Stocks | No Comments »
Inhibitex Inc INHX shares more than double on buyout news
Shares of hepatitis C drug developer Inhibitex, Inc. (Nasdaq: INHX) were up more than 140 percent from Friday's closing price in morning trading on Monday after it was announced over the weekend that pharmaceutical giant Bristol-Myers Squibb (NYSE: BMY) made a $26 a share cash to acquire Inhibitex.
The $26 cash offer for Alpharetta-based Inhibitex represents a 163 premium to Friday's closing price of $9.87.
"The acquisition of Inhibitex builds on Bristol-Myers Squibb's long history of discovering, developing and delivering innovative new medicines in virology and enriches our portfolio of investigational medicines for hepatitis C," said Lamberto Andreotti, chief executive officer, Bristol-Myers Squibb in a January 7 press release. "There is significant unmet medical need in hepatitis C. This acquisition represents an important investment in the long-term growth of the company."
Inhibitex's lead hepatitis C asset is INX-189, an oral nucleotide polymerase (NS5B) inhibitor in Phase II development that has exhibited potent antiviral activity, a high barrier to resistance and pan-genotypic coverage.
"The addition of Inhibitex's nucleotide polymerase inhibitor to our own promising portfolio, which includes other direct-acting antivirals, brings additional options to develop all-oral regimens with better cure rates, shorter duration of therapy and lower toxicity than the current standard of care," said Elliott Sigal, M.D., Ph.D., executive vice president, chief scientific officer and president, R&D, Bristol-Myers Squibb said in a statement.
The transaction is expected to be dilutive to earnings for Bristol-Myers Squibb through 2016, with an expected impact on earnings per share of approximately $0.04 in 2012 and approximately $0.05 in 2013, the January 7 press release stated.
About Inhibitex, Inc. (Nasdaq: INHX)
Inhibitex, Inc. is a biopharmaceutical company focused on developing products to prevent and treat serious infectious diseases. The Company's clinical-stage pipeline includes two Phase 2 development programs for which it has retained all future rights: INX-189, a nucleotide polymerase inhibitor in development for the treatment of chronic HCV infections, and FV-100, a nucleoside analogue in development for the treatment of shingles-associated pain. The Company also has additional HCV nucleotide polymerase inhibitors in preclinical development and has licensed the use of its proprietary MSCRAMM® protein platform to Pfizer for the development of a staphylococcal vaccine, which is currently being evaluated in a Phase 1/2 clinical trial.
For additional information about the Company, please visit www.inhibitex.com.
Tags: acquisition, bmy, Inhibitex, INHX
Fonar Corp. (FONR) shares soar as Q1 net income increases 360 percent
Shares of MRI company Fonar Corp. (Nasdaq: FONR) were up as much as 26 percent from Monday's closing price in morning trading on Tuesday after the company reported a 360 percent increase in first quarter earnings driven by an increase in management and service revenue, and a decrease in costs and expenses, offset by a decrease in product sales.
Fonar's net income for the first quarter of fiscal 2012 increased to $1.8 million, from $363,0000 a year earlier. Basic earnings per common share increased 257% to $0.25 per share during the first fiscal quarter of fiscal 2012 as compared to $0.07 per common share for the first fiscal 2011 quarter ended September 30, 2010. In addition, the diluted earnings per common share increased 243% to $0.24 per share during the first fiscal quarter of fiscal 2012 as compared to $0.07 per common share for the first fiscal 2011 quarter ended September 30, 2010.
Total revenues rose 11 percent to $9.6 million, compared to $8.7 million for the same period last year. Total operating costs and expenses decreased 5 percent to $7.8 million, from $8.3 million a year ago. Fonar's product sales in the quarter ended September 30, 2011 dropped to $1.8 million, from $2.7 million a year ago. Service and repair revenue increased to $2.9 million in the quarter, from $2.7 million a year ago, and revenues from management and other fees increased to $4.9 million, from $3.3 million a year ago.
""Over the last six quarters we have a net profit of $4.9 million," said Dr. Raymond Damadian, Fonar's Chairman and CEO in a November 15 press release. "This is due to changes that we have had to make including a focus on the management of our ten UPRIGHT® MRI imaging centers and some difficult cost reductions. While sales are not as robust as in prior years, we believe sales of the UPRIGHT® Multi-Position™ MRI will increase as the U.S. economy continues its recovery. This is because the UPRIGHT® MRI has huge value in medicine when it comes to diagnosing the spine. As time goes on, more and more physicians and patients recognize this. The discovery that an interrupted CSF flow causes MS is a valuable discovery and one that will immensely help those poor souls afflicted with the symptoms of MS as well as FONAR tremendously."
Tags: earnings news, FONR
Posted in Health Care Stocks, Penny Stocks, Technology Stocks | No Comments »
Anika Therapeutics, Inc. (ANIK) soars after Q3 results
Thursday, November 3rd, 2011
Shares of Anika Therapeutics, Inc. (Nasdaq: ANIK) were up as much as 28 percent from Wednesday's closing price, in morning trading on Thursday after the Bedford-based company announced third quarter revenue and profit increases, over the same period a year ago.
Shares touched an intraday high of $7.75, up from Wednesday's closing price of $6.04.
For the three months ended September 30, 2011, Anika Therapeutics reported revenue of $18.5 million, a 33 percent increase over revenue of $13.9 million reported in the same quarter last year. Operating income for the third quarter of 2011 increased to $4.8 million, up from $2.1 million in the same period a year ago. Net income rose to $3 million, or 22 cents per diluted share, up from $1.2 million or 9 cents per diluted share last year.
"Fueled by 35% growth in product revenue and continued operational streamlining, this was an excellent quarter for Anika," said Charles H. Sherwood, Ph.D., president and chief executive officer in a November 2 press release. "Our product revenue growth was driven by strong U.S. and international sales of Orthovisc, as well as increased shipments of our ophthalmic products and the advanced wound care products from Anika S.r.l. that we have added to our dermal franchise, highlighted by Hyalomatrix®. In addition to contributing to our top-line growth, Anika S.r.l. continued to reduce its net loss in the third quarter."
Headquartered in Bedford, Mass., Anika Therapeutics, Inc. develops, manufactures and commercializes therapeutic products for tissue protection, healing, and repair. These products are based on hyaluronic acid (HA), a naturally occurring, biocompatible polymer found throughout the body. Anika's products range from orthopedic/joint health solutions led by Orthovisc, a treatment for osteoarthritis of the knee, to surgical aids in the ophthalmic and anti-adhesion fields. The company also offers aesthetic dermal fillers for the correction of facial wrinkles. Anika's Italian subsidiary, Anika S.r.l, provides complementary HA products in orthopedic/joint health and anti-adhesion, as well as therapeutics in new areas such as advanced wound treatment and ear, nose and throat care. Anika S.r.l.'s regenerative tissue technology advances Anika's vision to offer therapeutic products that go beyond pain relief to protect and restore damaged tissue.
Tags: ANIK, earnings
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Following Links are various ministries recommended by As It Reads.
Disclaimer: While we at As It Reads recommend the following sites as further resources on the subject of Trinity, the views, opinions and beliefs of any link provided below, do not necessarily agree with everything that we believe. Furthermore, one particular website's view on any particular belief should not be regarded as a standard for the rest of the believers who rejects the teachings of Trinity. Therefore, please use these resources at your own discretion. Please feel free to contact us if you have any questions or concerns on any of the following links and what they believe. God bless!


text:
Naomi Berger
Associate Scenic Supervisor
Naomi Berger was attending New York University School of the Arts (now Tisch School of the Arts) as a lighting design student when she met Oliver Smith, who opened up the world of scenic design to her. She became his student and later had the honor of assisting Smith on such masterworks as Hello, Dolly! and West Side Story. While at NYU, Naomi met fellow student Rosaria Sinisi. Over the years, the two have worked together in various design capacities. After leaving the theater world, Naomi became a graphic designer and brand expert, always keeping the lessons she learned from Smith foremost in her mind. She was delighted when Rosaria asked her to assist in re-envisioning Oliver Smith's iconic 1956 My Fair Lady scenery. Naomi views this project as an attempt to pay tribute to both Oliver Smith, an extraordinary man who continues to have a profound influence on her life, and to her lifelong friendship with Rosaria Sinisi.
Image © AL HIRSCHFELD, reproduced by arrangement with Hirschfeld's exclusive representative, the MARGO FEIDEN GALLERIES LTD, NEW YORK. alhirschfeld.com
Associate Scenic Supervisor –


text:
Q: Gnome shell: automating windows and placement First off, sorry if this isn't the best formed question. I've tried to research the best part of the stack to focus on, but I'm still not 100% sure I've got it.
So, I'll explain the outcome I'm after:
On Ubuntu 20.04 (GNOME Shell 3.36.9 / Xorg) I have a window configuration I set up every morning (for our company stand up): one Firefox window snapped to the right column with a URL open, and one snapped to the left column with another URL.
I understand how to open a URL in a browser, but the thing I want to automate is a little different:

*

*Open a new browser window in a new workspace (ideally at the top of the workspaces)

*Snap that window to the right

*Open another new browser window in the same workspace, snapped left

*Have both browser windows open the URLs I'm after

*Bonus points for opening them in the Firefox containers I use, but I appreciate that's a Firefox issue, not a Gnome one.

Ideally this would be something I can script using bash or python.
My question is: is this sort of thing even possible? What APIs or tooling should I be looking at, or are there projects that do this sort of thing already? It seems like a useful thing to have, as everyone must have a set of common window setups they want to save.
My lack of understanding of the Gnome ecosystem is making this hard to search for.

A: You can manipulate windows using wmctrl and xdotool, and in addition, daemons such as devilspie and devilspie2 allow you to define rules for specific windows. When a window is created that matches your criteria, these tools can automatically manipulate them, i.e. resize and position them, and move them to a different workspace. You will mist likely need to be logged in on the Xorg server (default prior to Ubuntu 21.04). They may not work, or at least be limited, under Wayland.
wmctrl and xdotool
If you only need to set up a configuration at login, you can work with wmctrl and xdotool. With wmctrl, you can move to a different workspace, then have your script launch an application. xdotool may then be most suited to "search" the window and resize and place it. It features a --sync option that causes the command to wait until the window is effectively created.
devilspie or devilspie2
devilspie2 is a successor of devilspie that uses a different syntax (Lua) in the configuration file. With these tools, you define rules in which you state what should happen with a window that matches certain criteria. As soon as such window is created, devilspie will manipulate it according to the instructions, i.e., resize and position it, move it to a different workspace, ...
Thus, you could define rules for the specific Firefox windows you want to place during startup. When the windows are created by an autostarter or by a script you run on startup, devilspie will manipulate them automatically as they are created.

redpajama_set_name: RedPajamaStackExchange