text:
Europe/India/Near East USA Asia
Bachem AG Bachem Americas, Inc. Bachem Japan K.K.
Hauptstrasse 144 3132 Kashiwa Street Ueno Bldg, 8F
4416 Bubendorf - Switzerland Torrance, CA 90505 - USA 1-9-10 Nihonbashi-Horidome cho, Chuo-ku
Tel +41 58 595 2021 Tel +1 888 422 2436 Tokyo 103-0012 - Japan
Fax +41 58 595 2040 Tel +1 888 4BACHEM Tel +81 3 6661 0774
Email sales.ch@bachem.com Fax +1 310 539 9428 Email sales.jp@bachem.com
E-mail sales.us@bachem.com
| Online Shop
Technological Capabilities
Analytical Data Sheet (ADS)
Bachem App
Peptide Calculator
Peptide Content Calculator
New Product Alerts
Peptide Trends November 2020
Peptide Trends October 2020
Oligonucleotide Trends September 2020
Peptide Trends September 2020
Peptide Trends July 2020
Peptide Trends June 2020
Peptide Trends May 2020
Peptide Trends April 2020
Peptide Trends March 2020
Peptide Trends February 2020
Oligonucleotide Trends January 2020
Peptide Trends January 2020
Glossary & Abbreviations
PEPTIDE TRENDS AUGUST 2018
MEET US AT IMAP 2018
The 8th International Meeting on Antimicrobial Peptides (IMAP 2018) will take place in Edinburgh, UK on September 2 – 4, 2018. IMAP 2018 will cover both the antimicrobial activity of peptides as well as their role in regulation and modulation of the immune system.
Bachem's offer for research of the immune defense system comprises a broad choice of AMPs peptides and fragments including LL-37, Cecropins and Defensins. Our large selection of research peptides is available from stock. Our distribution centers in the US and in Europe allow fast delivery worldwide. With our record of accomplishment in custom synthesis projects, the high quality of our peptides for research and development projects and our capacity to upscale the production of simple and modified peptides, we are the Pioneering Partner for Peptides.
We are excited to meet with you, learn your needs for Antimicrobial Peptides and discuss how Bachem can assist to advance your research.
We invite you to drop by our booth or to contact us to schedule a meeting at the IMAP 2018.
PSEUDOPROLINE DIPEPTIDES
The synthesis of very long peptides and «difficult sequences» by chemical means still poses a challenge to the peptide chemist. The difficulties encountered during such syntheses usually are due to the aggregation of the resin-bound peptide. Proline residues disrupt such ordered structures efficiently. Temporary proline mimics can be readily obtained from serine and threonine by oxazolidine or from cysteine by thiazolidine («pseudoproline») formation. Both 2,2-dimethyloxazolidines and -thiazolidines are smoothly cleaved by trifluoroacetic acid and thus suitable for Fmoc-SPPS. Disruption of serine- and / or threonine-containing aggregates is achieved as well by introducing depsipeptide («O-acyl isopeptide») bonds into the peptide backbone. The resulting isopeptide is rearranged yielding the desired sequence in slightly basic solution.
Stepwise Fmoc-SPPS may become very difficult or even fail if the resin-bound peptide aggregates. Unfortunately, the predictions of «difficult sequences» based on an assumed propensity of the sequence to form β-sheets are not very reliable, with the exception that such aggregates cannot be formed in the vicinity of proline. The induction of a cis-amide bond by proline disrupts β-sheets as well as α-helices.
The aggregation of serine-, threonine- or cysteine-containing peptides during Fmoc-SPPS can thus be efficiently prevented by introducing the Fmoc-protected oxazolidines or thiazolidines, which can be obtained from these amino acids and aldehydes or ketones (Fig. 1).
These heterocycles have been appropriately termed pseudoprolines. The pseudoproline approach, originally developed by Manfred Mutter et al. at EPFL Lausanne, usually employed the serine and threonine derivatives, as the oxazolidines were cleaved more readily by acids than the thiazolidines. In the meantime, thiazolidine cleavage conditions suitable for standard Fmoc-SPPS have been developed. The incorporation of cysteine pseudoproline derivatives facilitated the synthesis of cysteine-rich peptides, which will also benefit from milder deprotection conditions. The acid lability of both types of heterocycle can be fine-tuned by the choice of substituents at the 2-position. The isopropylidene group of the oxazolidine (X = O, R', R'' = CH3) proved to be the best choice for Fmoc-SPPS, as the cycle is opened readily yielding serine (R = H) or threonine (R = CH3) during the final cleavage with TFA. Both isopropylidene (X = S, R', R'' = CH3) and benzylidene (X = S, R' = 2,4-Dimethoxyphenyl, R'' = H) derivatives have been used for incorporating cysteine, as the rings can be cleaved by TFA. The main drawback of this approach is the difficult coupling of the following amino acid to the hindered heterocycle. To circumvent this, Fmoc pseudoproline dipeptides were introduced (Fig. 2).
The coupling of these building blocks represents the most straightforward method to incorporate pseudoprolines The «preventive» insertion of such moieties is highly recommended when synthesizing long peptides lacking prolines (Fig. 3).
The repeated inclusion of pseudoproline units during the elongation of the peptide will improve the overall coupling efficiency, even if aggregation does not pose a severe problem. A considerable number of syntheses of long or «inaccessible» peptides, which succeeded only due to the insertion of pseudoprolines in appropriate positions, has been published since the introduction of these derivatives. Difficult peptides as IAPP or RANTES could be synthesized following standard Fmoc-SPPS protocols after evaluation of the required number and optimal position of the oxazolidine moieties to be inserted. As with Fmoc amino acid derivatives, couplings can be accelerated by microwave irradiation. Pseudoproline dipeptides show their high versatility as building blocks not only during the SPPS of long and difficult peptides. When synthesizing short peptides, a distinctly purer crude product may be obtained by incorporating merely a single pseudoproline unit. The heterocycles are left intact when cleaving fully protected peptide fragments from SASRIN or 2-chlorotrityl resin with diluted TFA and their presence markedly increases the solubility of the cleavage products. Accordingly, the purification and coupling of the fragments as well as the modification of partially protected peptides in solution are facilitated by insertion of pseudoproline moieties.
As fragments containing a C-terminal proline, fragments with a C-terminal pseudoproline can be coupled with minimal concomitant racemization. Hence pseudoproline dipeptides may establish additional possibilities in convergent peptide synthesis. The incorporation of an oxazolidine moiety greatly facilitates cyclizations of serine- or threonine-containing peptides, disulfide bridge formations, as well as head-to-tail cyclizations. The increased tendency to cyclize is due to the presence of a temporary cis-amide bond in the molecule.
Even though cysteine occurs only rarely in peptides and proteins, far less often than serine and threonine, the incorporation of cysteine pseudoproline is highly attractive due to the peculiar properties of the amino acid. Postma and Albericio showed that on-resin macrocyclization of cysteine-containing peptides proceeds more smoothly if Cys(Trt) is replaced by a cysteine pseudoproline. They also observed that cysteine 2,2-dimethylthiazolidines are opened during the final cleavage with TFA/TIS/H2O (95:2.5:2.5), cleavage duration and temperature depend on the nature of the subsequent amino acid. As their oxazolidine counterparts, cysteine pseudoprolines facilitate end-to end cyclization. The option of desulfurizing the amino acid may add alanine to the choice of amino acids allowing insertion of a pseudoproline dipeptide. Cysteine derivatives are notorious for their propensity for racemization when activated. Use of the appropriate thiazolidine dipeptides allows avoiding this risk, an advantage worth considering when synthesizing multiple disulfide bridge-containing peptides or anchoring cysteine to carriers.
If its thiazolidine ring is left intact, 2,2-dimethylthiazolidin-4-carboxylic acid (Me2Thz), conveniently introduced as pseudoproline dipeptide, acts as a highly effective cis-proline mimic. An analog of the cyclopeptide phakellistatin 19 containing three Me2Thz residues replacing proline, all of them incorporated by coupling pseudoproline dipeptides, showed enhanced activity. For synthesizing peptides containing this proline surrogate the standard TFA-labile lateral protecting groups may have to be replaced by highly acid-labile moieties such as Mtt (His), Trt (Ser) or OPp (Glu).
Isoacyl Dipeptides
A major disadvantage of the pseudoproline approach cannot be left unmentioned: The solubilizing effect of the oxazolidine moiety is lost when deblocking the peptide with TFA. Albeit the quality of the crude product may be vastly improved, further purification will be tedious due to its low solubility.
The N-O shift, a notorious side reaction during HF cleavage, turned out to be the key to the solution of this dilemma. This acid-catalyzed rearrangement involving the hydroxyl moiety of serine or threonine residues can be smoothly reversed by keeping the peptide in a slightly basic medium (Fig. 4).
As the N-O shift, i.e. O-isoacyl peptide formation, causes a disruption of the secondary structure, it is accompanied by an increase in solubility. At first, this type of depsipeptide was obtained by Fmoc-SPPS involving on-resin esterification of the subsequent Fmoc-amino acid to the free hydroxyl moiety of an N-terminal Boc-serine/threonine followed by elongation of the peptide. Low conversions, concomitant racemization, and diketopiperazine formation during the subsequent SPPS cycle are the main drawbacks of this straightforward approach. The recently introduced Fmoc O-acyl dipeptides help to overcome these problems (Fig. 5), though diketopiperazine formation is not affected by the method chosen for introducing the ester bond (incorporation of more base-labile Bsmoc Nα-protection at this position helps to reduce the extent of this side-reaction).
As pseudoproline dipeptides, O-acyl dipeptides turned out to be versatile building blocks for the synthesis of difficult peptides such as β-amyloid (1-42), which indeed showed an improved solubility and reduced propensity for fibril formation, and insulin, where isoacyl dipeptides were inserted in both A- and B-chain. Peptides containing O-acyl bonds to serine or threonine may act as soluble prodrugs, hence they have also been termed «switch peptides» (Fig. 6).
β-elimination of O-acyl dipeptides during activation has been described by Coin et al. If this side reaction poses a problem pseudoproline dipeptides should be incorporated in place of the isoacyl dipeptide to disrupt the aggregated structure.
Product Monograph Pseudoproline Dipeptides
DE-RISKING THE PROCESS OF PEPTIDE MANUFACTURE
The quality of a material produced by a manufacturing process depends entirely on the process itself, and the robustness built into that process during the development lifecycle. For a number of years, many companies have been looking towards the Quality by Design (QbD) approach to process development to ensure this robustness, and Bachem is no exception. Bachem, the world's longest established and largest manufacturer of Peptide APIs, prides itself on the quality and consistency of peptide API produced for customers. One of the lynchpins of this success has been derived from FDA guidance on QbD approaches and Quality Risk Management.
The International Committee for Harmonization (ICH) defines QbD as follows:
«A systematic approach to development that begins with predefined objectives and emphasizes product and process understanding and control, based on sound science and quality risk management.» This provides a framework for us as a contract manufacturer, in collaboration with customers, to gain product and process understanding for the manufacture of Peptide API with clear goals having been defined:
Gain as deep understanding as possible of the process starting at the earliest possible stage
Partner with customers at every point during development (intended use drives the quality requirements of the final product)
Gain full understanding of relationship between every stage of the process and the final product
Finalize a commercial process delivering the best quality of material for the intended use
These goals can be achieved, in principle, by a forward-thinking approach, commencing with an ongoing systematic review of the entire manufacturing process, and all elements therein. Such a review allows the proactive identification of emerging and/or potential risks to every step of the process based on the development stage, the experience gained so far of that specific process as well as prior knowledge of similar processes. Once risks have been identified, there follows the possibility to mitigate those risks, again in a proactive manner, to end up with the best process for the material required.
Further to this, ICH guideline Q11 «Development and Manufacture of Drug Substances» recommends an enhanced approach to manufacturing process development incorporating elements such as prior knowledge and targeted experimentation to identify material attributes and process parameters that could affect drug substance Critical Quality Attributes (CQAs). Using these principles, the functional links connecting material attributes and process parameters to CQAs can be determined. This enhanced approach, combined with ICH guideline Q9 «Quality Risk Management», an appropriate control strategy can be established for the manufacturing process for later phase clinical trials, process validation and filing.
During process development, a control strategy is required to ensure that potential risks to the manufacturing process, and indeed the CQAs of the material emerging from that process, are minimized to an acceptable level for process validation and filing. Failure to establish such a control strategy can have profound impact on the quality of the material, leading to potential batch failures and in the worst cases even compromising patient safety. Introduction of a Quality Risk Management system at the appropriate time during development ensures that risks are identified and minimized, and such events do not take place.
A sensible control strategy is defined by the characterization of the manufacturing process. Process characterization is performed as a multi-step activity which comprises risk assessment, followed by work-packages and experiments designed to allow mitigation of risks emerging from the assessment. This iterative process is focused on Process Validation (PV, otherwise known as Process Performance Qualification or PPQ) readiness, as once the pre-PPQ manufacturing campaign has started, the process is effectively «locked» in its final form.
Process characterization, as stated in the previous paragraph, requires a risk assessment and mitigation process. The first step of this is naturally identification of process risks. There are a number of ways of approaching the identification and assessment of risks in a manufacturing process. Bachem has previously explored a number of these and has selected the concept of FMEA or «Failure Modes and Effects Analysis» as the method of choice.
FMEA is defined as «a systematic procedure for the analysis of a process or system to identify the potential failure modes, before they occur, and their potential causes and effects on that system performance». The manufacture of peptides falls under «process» in this definition, and hence the principles of FMEA can be applied as a systematic analysis of the manufacturing of a peptide API to identify risks, or failure modes. Once this has taken place, they can be characterized as far as possible, and steps can be taken to mitigate those risks or failure modes should they be considered potentially damaging to the ability of the process to produce peptide API of the appropriate quality. In an ideal world, FMEA would identify every risk, and work-packages could be developed to mitigate those risks entirely. The real world dictates a more pragmatic approach, and so the goal falls more into the realms of evaluating the available process knowledge (depending on the manufacturing experience and clinical phase). From there, a list of manufacturing risks can be generated, and those risks can be prioritized according to impact on Critical Process Parameters (CPPs) and therefore CQAs. The final stage is to use this list to guide the efforts and resources to focus on priorities for work-packages and other activities for further process characterization activities to bring the manufacturing process closer to validation (or PPQ) readiness.
Figure 1 Quality risk management (ICH Q9) – risks must first be identified and assessed, following which a control strategy can be developed to reduce risks to an acceptable level for process validation and filing.
FMEA as a concept drives the understanding of risks and their impacts. The term «Failure Modes» itself holds as an inherent meaning the concept of risks, or «what could go wrong». The «Effects» naturally refers to the impact of something going wrong, and «Analysis» attempts to define or quantify the likelihood and potential impact of an adverse event taking place during manufacturing. In the context of a peptide manufacturing process, the failure modes or risks have potential impact on CQAs of the API material emerging from the process, and thus have potential to impact patient safety, hence a robust methodology is needed to identify such risks.
Bachem applies FMEA by undertaking a systematic review of the entire manufacturing process, looking for risks or failure modes at every single step. Synthetic peptide manufacture typically follows 4 stages:
Solid phase peptide synthesis (peptide chain built on a solid support)
Cleavage of the peptide chain from the solid support
Purification of the peptide chain
Isolation of the final API (usually by lyophilization).
Each stage requires comprehensive Batch Production Records in order to create a repeatable process. Together the 4 sets of batch documentation provide a line-by-line description of the overall manufacturing from start to finish. The Batch Production Record templates (known within Bachem as Master Batch Production Records or MBPRs) provide the basis for the FMEA.
The first stage of the FMEA is familiarization with the process as it exists. As suggested in the previous paragraph, this depends heavily on the MBPRs, as well as any other prior knowledge that may exist, such as process development reports, as well as knowledge held by the manufacturer. This, and the rest of the FMEA process, is carried out as a team effort, with all technical, quality and analytical aspects of manufacturing being represented. It is at this stage that subject matter experts are also drawn into the workflow, as the insight they offer is invaluable.
The next stage is to set up the FMEA into a meaningful medium for the risk assessment proper. Bachem performs this by setting up a table in Excel, listing every process parameter as a separate item. In essence this means that every line in a MBPR is listed as a separate line in the table. Following this comes the population of the table. Each line is populated with data collected from numerous sources, including the executed batch production records from previous manufactures, process development reports and other batch data and know-how. Once the template table has been completed, the risk assessment itself can progress. It should be noted that once the risk assessment is completed, the outcome and relevant information are compiled in a report.
Risk of an adverse event taking place on a single process parameter, or process step, depends on a knowledge of the operating ranges of that parameter. In general, a «set point» or ideal operating point is required, around which appropriate operating ranges can be configured. The characterized range, as the name suggests, is the operating range of parameters that have been actively measured during process development or through prior knowledge. The proven acceptable range also depends on prior knowledge or direct measurement, and is the range of operation within which the risk to CPPs or CQAs have been proven to be acceptable. Finally, the normal operating range (generally much tighter than the proven acceptable range) which defines the optimal working range of a parameter designed to allow minimal risk of impact on CPPs and CQAs. As part of Bachem's approach to minimizing risk, normal operating range is usually defined as a calculated proportion of proven acceptable range (see Fig. 2).
Figure 2 Parameters established and used in FMEA.
The assessment of risks for each process parameter should be systematic and meaningful, as well as objective and standardized. Bachem has developed a risk rating system that allows such a standardized approach, while incorporating the element of risk identification (the «what could go wrong»). A score is assigned to each of three elements based on the outcome of the assessment. Those elements are severity of effect (or excursion) on the final drug substance (or CQA), the likelihood of occurrence of the effect (or excursion) and finally the probability of detection of an excursion should it have occurred. The framework for assigning scores to these elements is summarized in Table 1.
Score Severity (S) of effects on final DS Likelihood of Occurence O) Probability of Detection (D) (IPCs and release testing)
5 Severe Frequent Absolutely uncertain
4 Major Likely Remote
3 Moderate Occasional Moderate
2 Minor Unlikely High
1 Insignificant Remote Almost certain
The scoring for each category is assigned as a team effort, incorporating the input from subject matter experts, based on the concepts of the operating ranges as described earlier in this article. It should be noted that the team effort generally incorporates input and/or comprehensive discussions with our clients, as desired. The output is designed to be an objective risk assessment that provides a meaningful measure of the impact of operating range excursions, constrained by the pragmatic measures of likelihood of an excursion and the possibilities to detect such an excursion should it exist.
Combining the 3 scores, it is possible to define a risk classification. Bachem follows a system of assigning a Risk Prioritization Number (RPN), which is based on a simple calculation of:
RPN = Severity x Occurrence x Detection
The RPN can then be used to drive decisions around the mitigation strategies for any individual parameter (process step, or line of the MBPR).
Bachem takes a conservative approach to the assignment of RPNs, in this context, to provide a manufacturing process that is as stable, robust and risk-free as possible. The scoring system is summarized in Table 2.
Table 2 Risk classification and mitigation measures according to Risk Prioritization Number (RPN). Colours used in this table are those used in the FMEA document itself for clarity and ease of interpretation.
For a complete mitigation-free approach, the scoring is very low. The scoring range where further investigation or active mitigation is required covers more than 90% of the scoring range. The outcome of this is that there is almost a statistical guarantee that each process step will be actively assessed based on risk. The scoring categories are labelled in the Excel FMEA table with colors (as shown in Table 2) which also makes a straightforward overview of process steps where mitigation measures are recommended or required.
The final part of the overall FMEA process is the mitigation stage – after all, identification of risk is merely an academic exercise without the ability to use the information gained. Risk mitigations, knowledge gaps and process improvements can be actively pursued based on the outcomes of the FMEA. The characterization score can be used to focus the resources based on the severity of the risk, or the ability to detect the outcome of that risk.
Risk mitigation and plugging knowledge gaps generally requires experimentation, or at the very least a reliance on prior knowledge. Process Characterization is a series of experiments, generally emerging from the output of the FMEA, which varies operational process parameters in a systematic way in order to determine the impacts of such excursions on drug substance quality (CQA) and process performance parameters (CPPs). Bachem, as a CMO, relies heavily on the input and experience of customers in the compilation of process characterization experiments, and indeed this part of the risk mitigation is performed in close collaboration with our clients. The process characterization work is split into work-packages of a defined scope, designed to address specific risks emerging from the FMEA assessment. The outcomes of the work-packages provide the confidence that the process is de-risked and suitable to proceed to process validation. Data generated from work-packages are documented in reports to benefit the current process, but also potential future processes, and also to provide a customer a comprehensive overview of the risk mitigation undertaken.
Examples of risk mitigation specifically related to peptide manufacture are of course many and varied, however a few are captured below:
Stage 1 (SPPS)
Influence of starting materials on final impurity profile
additional IPC
Stage 2 (TFA cleavage)
Hold times and temperatures for intermediate solutions
Stage 3 (Purification)
Influence of residual solvents (e.g. IPE, ACN) on purification (typically preparative HPLC)
Stage 4 (Ion exchange, final isolation of DS)
Impact of e.g. reduction of free AcOH in freeze drying step
Control over water uptake of DS during final packaging
Lyophilization cycle and maximum batch scale
In summary, the FMEA approach to risk assessment and mitigation is a proven method of risk identification, assessment and characterization, based on the QbD approach. These are enshrined in ICH guidelines Q8, Q9 and Q11, which exist only to push API manufacturing processes towards greater robustness, and material quality suitable for the intended application. The FMEA itself provides a deep and comprehensive overview of risks at every step of the process, and allows work-packages to be constructed (with input from subject matter experts and customers) that eliminate or constrain those risks. Risk assessment is essentially a mandatory part of an API development lifecycle, and the FMEA approach provides a systematic approach, with the intention of proceeding to a successful process validation, launch and commercial supply of API.
FDA Guidance for Industry «Process Validation: General Principles and Practices (R1)»
ICH Harmonised Tripartite Guideline «Pharmaceutical Development Q8 (R2)»
ICH Harmonised Tripartite Guideline «Quality Risk Management Q9»
ICH Harmonised Tripartite Guideline «Development and Manufacture of Drug Substances (Chemical Entities and Biotechnological/Biological Entities) Q11»
MEET BACHEM: NEIL HARRISON, GROUP LEADER PURIFICATION
PT: What is your official job title at Bachem?
Neil: Group Leader Purification, Bachem UK
PT: How long have you been with Bachem?
Neil: I started working for Peninsula Labs Europe in November 1989, which was acquired by Bachem in 1999. Therefore, I have been here for 28 years!
PT: Briefly, what do you do at Bachem?
Neil: As Group Leader of Purification, I am responsible for the Purification Department at BUK. As a group, we purify over a hundred different synthetic peptides every month.
PT: What do you like to do outside of work?
Neil: I like spending time outside, anything from gardening, walking, cycling, fishing, skiing etc.
PT: What makes a perfect day for you?
Neil: Strolling along a beach in Barbados.
PT: What do you like most about your job?
Neil: Having purified peptides for 28 years, the best thing about my job is the constant change. Technology is constantly improving, allowing for the manufacture of increasingly difficult and complex peptides.
PT: What do you do for fun?
Neil: I enjoy travelling a lot, especially for European city breaks. I also enjoy finding and drinking different craft beers. Sometimes, I am able to enjoy both of these at the same time.
PT: What is your preferred peptide?
Neil: I never would have thought I would say this, but Amyloid β-Peptides. They are easily the most difficult group of peptides that we have tried to produce. But through many incremental improvements in synthesis, cleavage and purification, we can know manufacture many analogues for Alzheimer's research.
PT: Thank you very much Neil.
PEPTIDE HIGHLIGHTS
Interesting news about peptides in basic research and pharmaceutical development:
Potential malaria killer designed by Australian researchers-University of Queensland
New target is an apparent triple threat to pneumonia-Augusta University
After breathing new life into old mice, senescence startup Cleara bags cash to move toward the clinic-FierceBiotech
Researchers create matchmaking service, for peptides and antibiotics-Science Daily
Bachem peptides and biochemicals are widely cited in research publications. Congratulations to all our customers with recent publications!
J. Han et al.
Lithocholic acid-based peptide delivery system for an enhanced pharmacological and pharmacokinetic profile of xenopus GLP-1 analogs.
Molecular Pharmaceutics 15, 2840-2856 (2018)
R. Roy et al.
Absolute quantitation of glycoforms of two human IgG subclasses using synthetic Fc peptides and glycopeptides.
Journal of the American Society for Mass Spectrometry 29, 1086-1098 (2018)
C.Y. Zamora et al.
Design, solid-phase synthesis and evaluation of enterobactin analogs for iron delivery into the human pathogen Campylobacter jejuni.
Bioorganic & Medicinal Chemistry (2018)
T. Zimmermann et al.
Preparation of enzyme-activated thapsigargin prodrugs by solid-phase synthesis.
Molecules 23, (2018)
© 2009-2021 avenit AG, Internetagentur - All rights reserved
| General Conditions
| Legal Statement


text:
Interview with Australian Writer Zenobia Frost
June 13, 2014 June 13, 2014 / Zenobia Frost
Blogger Geosi Gyasi interviewed me for his blog, Geosi Reads:
Credit: Raw Bones
Brief Biography: Zenobia Frost is an Australian writer and editor whose debut poetry collection, The Voyage, was released in 2009. Zenobia (Brisbane) is the assistant editor of Cordite Poetry Review. Her work has been published in Voiceworks, Overland, Southerly, The Lifted Brow and Rave Magazine. Zenobia was shortlisted in the 2013 Overland Judith Wright Poetry Prize and won second place in the 2013 John Marsden Prize for Young Australian Writers. Her debut collection, Salt and Bone, is forthcoming from Walleah Press.
Geosi Gyasi: Between Page and Stage, which one is your first love?
Zenobia Frost: Page, I think. Writing poetry was how I learned to be happy with my own company. I can fiddle with one line or one piece of punctuation for hours on end. Sometimes, when I write a new poem, I'm excited to wake up the next morning just to see it with fresh…
Blog, Interview, Poetry
geosi gyasi, interview, Poetry, zenobia frost
← Poem: "Varuna"
Ruckus! (and a poem) →

redpajama_set_name: RedPajamaCommonCrawl


text:
More articles about: basketball
NBA Watch: Knicks Succumb to Hornets on MLK Day, 97-87
It was a stellar Monday showdown at Madison Square Garden.
NEW YORK - The New York Knicks welcomed the Charlotte Hornets to Madison Square Garden Monday afternoon (Tuesday in Manila) for a Martin Luther King Day matinee showdown. With personalities such as Knicks legend Walt Frazier, New York City Mayor Eric Adams ...
Basketball Star and Actor Maoi Roca Dies
Maoi Roca, a basketball star who played in the UAAP and the MBA and then went on to find fame as a comedic actor, has passed away. He was 47 years old.The news was reported by Spin.ph and expressions of sympathy and ...
NBA Watch: Chicago Survives Brooklyn in Duel of Beasts of the East
Inside the matchup between the current two top teams of the NBA's Eastern Conference.
NEW YORK - The Brooklyn Nets, playing the second of a back-to-back and the last of a four-game home stand at Barclays Center before they depart on a five-day road trip, faced off against the Chicago Bulls Saturday night in a tussle ...
NBA Watch: Here's What Happened at the Season's First Game Between the Brooklyn Nets and the New York Knicks
It's the Battle of the Boroughs.
NEW YORK—The Brooklyn Nets hosted the visiting New York Knicks earlier this week in front of a packed Barclays Center crowd. Only it didn't seem like a home game for the BK squad with blue and orange taking over a significant portion of ...
'Shock the Game' With This Blacktop Battle Ready Basketball Shoe From Anta
The Tyler Durden of basketball shoes.
Alex Caruso is, hands down, one of the NBA's most exciting players. After thrilling the fans of Los Angeles the past four years, the Carushow is moving to the Windy City this season after the Chicago Bulls signed the 27-year-old guard to ...
WATCH: Revisiting The Infamous Gilas Pilipinas-Australia Brawl
The lowest point in Philippine basketball history.
The year is 2018.Our national basketball team, Gilas Pilipinas, was poised to make another run to qualify for the 2019 FIBA Basketball World Cup.Five years prior, in the 2014 World Cup, Gilas shocked the world by providing scintillating performances game after game. The ...
Nike's Filipino-Designed Giannis Immortality Is a Sneaker Fit for the Greek Freak
Try this on for size.
Our favorite Filipino Nike footwear designer Kevin Reyes' latest project presented him with the opportunity to work with yet another of the NBA's biggest names in Giannis Antetokounmpo of the Milwaukee Bucks. The Nike Giannis Immortality, set to release in Summer 2021, is ...
Go Retro With the New Balance BB550
The colorful basketball sneaker first made an appearance in the '80s.
We are slowly catching sight of the light at the end of the really long tunnel we've been in for over a year now. With the world slowly opening up again and more of us gradually seeing some semblance of normalcy little ...
First Jordan Store in the Philippines Opens in BGC
It's also the largest Jordan Store in Southeast Asia.
The first Jordan store in the Philippines is finally opening in December and it couldn't have come at a better time. Because the Philippines is one of the most basketball-obsessed countries in the world, it only makes sense that we're getting one ...


text:
Tacoma's Murray Morgan Bridge. Photo by itsbooyer via CC.
Murray Morgan Bridge to Close for $1.4 Million Upgrade
The historic Murray Morgan Bridge in Tacoma will close to traffic from July 9 through August 17 so Tacoma Power can upgrade power lines attached to the bridge. The $1.4 million project will support economic development and help carry more electricity to downtown Tacoma's Central Business District.
During the project, Tacoma Power will extend cables from the East F Substation across the bridge and connect them with the existing underground distribution system near Cliff Avenue in downtown Tacoma. The work will be completed by up to five wire crews trained in high angle rescue safety.
The bridge will reopen for Maritime Fest from July 26-29. Starting August 18 and continuing through the end of September, the bridge will be open to a single lane of traffic. Throughout the closure, boats that need the bridge lifted will still be able to pass, given they provide the standard two-hour notice.
Find alternate driving routes on Tacoma Power's website.
VA Announces Economic Success Event for Military Community
SPSCC Creates Small Business Loan Fund to Help Current and Former Students
UW Tacoma Center for Urban Waters Receives $330,000 Grant
Gig Harbor Completes $9M Harbor Hill Drive Extension


An accused nanny killer wept as he told a court his girlfriend killed their home help - and then told him to throw her body on the garden bonfire.
Sophie Lionnet, 21, was tortured and killed by Ouissem Medouni, 40, and Sabrina Kouider, 35, at their £900,000 Wimbledon home.
The couple interrogated Ms Lionnet in the bath, holding her head under water until she admitted sleeping with Kouider's ex boyfriend Mark Walton - who was a founding member of Boyzone, the Old Bailey has heard.
Her body was found by firemen on the garden bonfire two days later.
Kouider sobbed in court as her former lover blamed her, while Medouni claims he was fast asleep when Kouider drowned Ms Lionnet in the bath.
He says she begged him not to call the police and said: 'We'll burn her'.
Medouni told the jury: 'So Sabrina woke me up, it was probably around 1.30am. She said Sophie doesn't breathe.
'I woke up straight away and she was going to the bathroom so I was following her and I saw Sophie.
Kouider sobbed: 'What have I done,' the court heard.
'I was shocked to see her like that,' said Medouni.
He said he dragged the nanny out of the bath laid her on the floor and desperately tried to save her life with started CPR.
Kouider burst into tears and begged Medouni not to call the police, the court heard.
'I remained silent after that,' said Medouni.
Kouider wept throughout today's court proceedings as Medouni gave his account of the murder.
'I should have called the police,' he said.
He said the following day he bundled the nanny's body in a suitcase while the couple discussed what to do with her.
Eventually they agreed to set her body ablaze on the bonfire.
Medouni said: 'She took a shower and she shaved herself and she told me it's for cleaning, to clean her sin.
Medouni and Kouider, both of Wimbledon Park Road, Southfields, southwest London, each deny murder, but admit perverting the course of justice by burning the body.


J.J. and guest co-host Marissa sit down with St. Louis filmmakers Lacey Turner and Justin Holmes. Lacey and Justin explain how they started working together some years ago. They give insight on the culture of the film industry in St. Louis and how they are extending opportunities to others as doors open for them. Lacey and Justin talk about their upcoming premier of "The Greatest Stories Never Told" and how they feel about the Black Panther movie!
Be sure to catch their showcase of "The Greatest Stories Never Told" at the St. Louis Galleria on 3/15/18 from 6p-8p and the premiere of "The Lou" at 24:1 Theatre (St. Louis) on 3/25/18 at 9:30am.


Insurance Management Company's (IMC) has over 50 years of experience insuring contractors and we are well versed in the unique insurance and risk management exposures and challenges of the construction industry. We assist our clients in various aspects of the construction business, from contract inception to final completion.
Our client's construction experiences include: conventional power plants, cooling tower construction, waste-to-energy facilities, major pipeline installations, street and road construction and reconstruction, general commercial construction and trade specialties.
The importance and complexity of the various additional insured requirements often requested in construction contracts.
IMC is not your typical small town, family owned insurance agency, but rather a sophisticated, service intensive company that gives any large broker a run for their money. They have made a difference in limiting our exposures via tighter controls which allows us to focus much more on the daily micro and macro challanges of running the business.


the final sermons for Strength to Love, a volume of his most best-known homilies. King had begun working on the sermons during a fortnight in jail in July 1962. While behind bars, he spent uninterrupted time preparing the drafts for works such as "Loving Your Enemies" and "Shattered Dreams," and he continued to edit the volume after his release. A Gift of Love includes these classic sermons, along with two new preachings. Collectively they present King's fusion of Christian teachings and social consciousness, and promote his prescient vision of love as a social and political force for change.


text:
Rothesay Castle
Rothesay Castle Photo - User:Supergolden - Wikipedia - lic. under CC BY 2.5
Location: Rothesay, Isle of Bute, Scotland.
Notes: Rothesay Castle is a ruined castle in Rothesay, the principal town on the Isle of Bute, in western Scotland. Located at NS086646, the castle has been described as "one of the most remarkable in Scotland", for its long history dating back to the beginning of the 13th century, and its unusual circular plan. The castle comprises a huge curtain wall, strengthened by four round towers, together with a 16th-century forework, the whole surrounded by a broad moat. Built by the Stewart family, it survived Norse attacks to become a royal residence. Though falling into ruin after the 17th century, the castle was repaired by the Marquess of Bute before passing into state care in the 20th century. Following a long period of neglect, the 2nd Marquess of Bute employed 70 men to excavate the ruins, clearing large amounts of rubbish from the castle in 1816-17. But it was not until the 1870s that the ruins were stabilised. The 3rd Marquess, a keen restorer of historic buildings, embarked upon a series of repairs and restorations, following surveys and advice from his regular architect William Burges. His "restorations" continued until 1900, and include the clearing and shaping of the moat, as well as the red sandstone additions to the forework, which reinstated the hall roof while significantly altering the character of the building. In 1961 Rothesay Castle was given to the state, and is now a Scheduled Ancient Monument, in the care of Historic Scotland. The castle is open to visitors year round. Fine views can be seen from the top of the walls over the town and back towards the mainland.
How To Get To Rothesay Castle (Map):
Rothesay Castle Links:
Rothesay Castle On Wikipedia
Rothesay Castle � site information from Historic Scotland


BATTLE lines are being drawn in the fight to save Kingswinford's world famous glass museum from council closure.
Outrage about plan's to shut the Broadfield House site has united campaigners across the political divide, who say the tourist attraction must remain open.
Dudley South's Labour MP, Ian Pearson, threw his support behind the campaign to stop closure of the centre and moving its collection to Wordsley's Red House Glass Cone.
Mr Pearson said: "Closing Broadfield House and moving its collection would do considerable damage to the borough's deserved reputation as an internationally important centre for the study and appreciation of glass.
"The Red House Cone is a fantastic site, but so is Broadfield House.
"I will be putting all the pressure I can on the council to reconsider this ill-conceived budget cut."
Kingswinford South Tory councillor David Blood also vowed to oppose the closure plan, which the council's cabinet has already approved as part of this year's budget proposals to save borough museums £120,000 a year.
He added: "To move Broadfield House's collection to Stuart Crystal would be a major calamity.
"I don't think my residents would ever forgive me if I went along with it."
Dudley Council looks set to approve the closure on March 2, two days before the next select committee meeting to discuss the plan.
The Friends of Broadfield House met with council officials on Tuesday January 20 to call for a delay in the closure, planned for March 2010, while a new centre to house the collection is built.
Barbara Beadman, chairman of the Friends group, said: "They seem to have lost the plot in terms of our glass heritage.
"I don't think the decision should be made, It would be a travesty if it is.


The internet is a magical place where people from all over the world can connect with each other, unfettered from geographical limitations. It's where families who live on different continents can stay in touch, strangers in faraway cities can fall in love, and Jim Carrey and Italian fascist dictator Benito Mussolini's granddaughter can get into a feud.
The comedian-turned-political cartoonist (best known for films such as Dumb and Dumber, The Mask, Ace Ventura: Pet Detective and Ace Ventura: When Nature Calls) first angered Alessandra Mussolini (best known for being Benito Mussolini's granddaughter) when he posted one of his drawings on Saturday. It depicted her grandfather and his mistress, Claretta Petacci, strung up by their feet after they were executed by firing squad in 1945. "If you're wondering what fascism leads to, just ask Benito Mussolini and his mistress Claretta," Carrey wrote.
Alessandra then spent the rest of the day having a full-on Twitter meltdown, chiding Carrey for not drawing various historical American atrocities, and responding to critics.


Coping with back pain can be extremely stressful for anyone who has it. This reduces the mobility and gives you a nagging pain whenever you try to relax. However, you can now relax well with the help of a well-designed chair that has been specially made to relieve back pain.
Generally speaking, back pain is caused due to sitting for long periods on a desk and not exercising. This weakens the muscles as they do not get the stimulation that is needed.
While sitting down, you can get instant relief from your back pain. However, this means that you must be sitting in the right posture to ensure you can relax in the best way. For this, you need a chair that can help you get into this right posture. Here are some of the chairs that can help you do this.
Such chairs are powered by electricity. With these chairs, you can sit in the best position that you feel good in with a tilt of the chair either in the forward or backward position. This chair allows you to sit in a relaxing position so as to ensure alleviation of pain from the back, neck and joints.
Many recliner chairs allow you to almost lie completely flat with its footrest standing up and its backrest lowering so that you can sit in a relaxing position. Due to the extreme comfort it gives, such chairs are installed at many high profile cinemas for a unforgettable cinematic experience. You too can use these chairs in your living rooms to relax and watch your favourite movies while munching on popcorn or other snacks.
A recliner chair is one which only moves backwards to rest your back. It does not raise your legs. Despite this, recliner chairs are one of the best ways to relieve your back pain. You can get one for your home through which you can relax yourself thoroughly after a hard day at work. In fact, these chairs are also ideal for those who have mobility issues. They can be one way in which you can relax your muscles when they need to be relaxed the most. In fact, these recliner chairs are the best options for you if you want a piece of furniture that helps you to relax at home whenever needed.
If you need to buy such chairs, you can choose from manually operated to motorised ones depending on your requirements.
In the market, you can also get heat and massage chairs which give a whole new level of comfort and relaxation to you after a hard day at work. These chairs are ideal for those with constant back pain, mobility or circulation problems. These are an addition to the features offered by riser recliner and recliner chairs currently available in the market.
For those of you who crave to get comfort after a hard day of work or relaxation from nagging back pain, there is no doubt that Recliner Chairs In The UK and elsewhere are the best option for you. You can choose one based on your preferences and your budgetary constraints. Believe us, this will be one of the best investments you have ever made for yourself.


text:
Bell Boys in the city
September 5, 2014 1 min read
Cunard Bell Boys will take to the streets of Liverpool this weekend for their first official outing ahead of the line's 175th anniversary next year.
To mark the three Queens visit to the city in 2015 the bell boys will be in and around the crowds down at The Strand as the Tour of Britain cycle race takes to the roads on Sunday 7 September.
Liverpool City Council's cabinet member for culture and tourism, Councillor Wendy Simon, said: "It will be great to see the traditional bell boys in the city this weekend.
"The smart uniform and clean cut appearance shows just how much pride Cunard takes in their service, past and present.
"I hope that by having the bell boys on parade, we can really get locals interested in what will be one of our biggest maritime events the city has ever seen, when three of Cunard's largest ships will grace the river Mersey.
"It's going to be a marvellous weekend and one which I am sure will bring the crowds out in force, so get the date in your diary and don't miss it!"
Cunard Director Angus Struthers said: "Cunard's bell boys have become synonymous with tip-top service and our long maritime heritage. They will be the first to herald what we expect to be an outstanding series of events for Cunard in Liverpool next year."
From 24-26 May 2015, Liverpool will play host to the three largest Cunard ships ever built in an historic three-day event.
Queen Mary 2 will arrive on Sunday 24 May and stay overnight at the Cruise Liner Terminal, berthed in sight of the Cunard Building.
On Monday 25 May, Queen Elizabeth and Queen Victoria will sail into the city and all three ships will line up on the River Mersey. Queen Mary 2 will then sail out of Liverpool, as Queen Elizabeth berths at the landing stage where she will remain until she departs late that night.
Queen Victoria will be anchored in the Mersey throughout the day and evening, and will then take the berth when Queen Elizabeth sets sail.
Queen Victoria will set sail on Tuesday 26 May.
Health pioneers "meet" at new Liverpool hotel


Amy graduated from Purdue University, with a bachelor of science degree in management. She joined the Einterz team in 2012 and quickly found a passion for assisting clients that have an immediate need for veterans or Medicaid benefits. During this time, she has worked with families, home care agencies, assisted living facilities, and nursing homes throughout the state of Indiana to obtain benefits for hundreds of clients.
Based on her own family experience of helping to care for a loved one with Alzheimer's disease, she has sensitivity to the needs of clients experiencing any form of dementia. Amy will use her experience to help you face the unique financial and emotional challenges you will encounter when any form of long-term care is needed. Her goal is to protect as many of your assets as legally possible while getting your loved one the maximum benefit of quality care possible.
Ann graduated with honors from Hillsdale College with a Bachelor in Arts in English in 1994. She graduated in the top 26% of her class from Indiana University School of Law-Indianapolis with a Doctorate in Jurisprudence in 1997 and was admitted to practice law in Indiana at both state and federal courts the same year. Ann concentrated her practice in defense litigation and appeals in the Indianapolis area for many years until joining Einterz Law in 2014 and specializing in Elder Law and estate planning.
Ann developed her desire to assist the elderly and their families and caregivers based on her own experience helping her family care for her grandmothers, one of whom suffered Alzheimer's disease and lived with her and her family, and the other diagnosed with dementia. Ann's father is an Air Force veteran and served during the Vietnam War. Her main professional objective is to educate her clients about estate planning and asset preservation and help them achieve their goals and stay in control.


text:
Chronicles Main Menu Introduction to Chronicles An introduction to Chronicles with detailed information about the project Super Nintendo Entertainment System Release SNES Release's Opening Page Playstation Re-Release Opening page for Playstation re-release Nintendo Dual System Re-Release Opening Page of the Nintendo Dual System re-release Mobile iOS and Android Re-Release Opening Page of Mobile iOS and Android re-release Traversals and Interviews Documentation The documentation used for the traversals and Interviews Author and Contributors' Bios The bios of those who authored and produced Pathfinders Madeleine Philbrook 793490c7e41f4e0efe523b50970c1632a02f214b Nouspace Publications | Washington State University Vancouver
History and Features of Chrono Trigger Mobile iOS and Android Re-Release
1 2015-06-28T01:26:00-07:00 Dene Grigar ae403ae38ea2a2cccdec0313e11579da14c92f28 5497 21 History and features of Chrono Trigger Mobile iOS and Android re-release plain 2015-09-18T06:10:08-07:00 Madeleine Philbrook 793490c7e41f4e0efe523b50970c1632a02f214b
Shortly following the 2011 Wii Virtual Console re-release of the original Super Nintendo Entertainment System (SNES) release, plans to migrate Chrono Trigger to mobile devices arose, with Japan receiving a cellphone release via the i-mode distribution service on August 25 of that same year. Later, an iOS version compatible with contemporary versions of iPod, iPad, and iPhone devices was released on December 8, 2011, along with an Android version introduced on October 29, 2012. A new website was launched as well, showcasing a new video game trailer along with information concerning the story, characters, and worlds.
These iterations of Chrono Trigger were, as Square Enix co. establishes, based on the Nintendo Dual Screen (NDS) re-release with graphics "optimized especially for the iPhone/iPod touch."1 The game — although missing the "Arena of the Ages" multiplayer mini-game — features the new ending "Beyond Time's Eclipse," as well as the "Dimensional Vortex" and the "Lost Sanctum" areas developed for the NDS. What is most striking however, is the absence of the PlayStation (PS) cutscenes previously introduced in the Final Fantasy: Chronicles compilation — a decision that upset returning players.
A feature new to mobile devices, is the ability to "Bookmark" your progress, which creates a temporary save file upon quitting the game. This was a welcome improvement, since the original nature of relying upon save points located in particular areas was not ideal for the mobile gaming experience (which typically involves shorter moments of gameplay in comparison). However, this system was not without its qualms. When you restart the game, "you're returned to the entrance of whatever location you were in and, typically, all the enemies respawn" and the "Bookmark" function is not available during in-game plot animations or battles.2
In addition to this, the need to connect to the Internet in order to authenticate the legitimacy of the video game is frustrating and limiting to those who are not able to find an appropriate Internet connection. This is especially true for mobile devices, in which the typical owner is in transit when operating on said device. On top of this, there are abrupt moments where the game needs to download extra content before you can progress through the game. These actions by Square Enix co. — although justified — still convey an anti-piracy message to consumers that some may find rude and incriminating, not to mention constraining.
Furthermore, with the migration to mobile devices, the affordances of touch-screen controls that allow you to handle interactions simply by tapping on places of interest and the introduction of "an unanchored d-pad that lets you control movement from wherever you rest your thumb," theoretically should allow for more streamlined gameplay, but unfortunately, even this control-scheme suffered from lack of mobile optimization.3 Reviews describe that the "movement sensitivity is far too high," in the end causing you to "overshoot your mark."3 This issue results in fighting feeling "less intuitive" and ultimately tougher for the player — however, that said, menu navigation for shops, conversations, and status screens are arguably more fluid and responsive than ever before, due to the presence of large menu buttons and the introduction of a more legible font.2
Visuals and animations — although described as "optimized" — also took a turn for the worst, with numerous customer reviews detailing the prevalence of "graphical glitches" that cause sprites to "flicker" and "square boxes around sprites" to appear.4 A lack of sprite animation is also noted, and due to a "lack of retina support," the up-scaled visuals are poor in comparison to all previous installments of Chrono Trigger.5 The music and sound effects also received poor reviews, with players complaining about audio quality, and as one review laments, "instruments that used to sound almost orchestral have been reduced to bleeps and bloops."6
However, it should be noted that Square Enix co. has continually updated the mobile re-release on both iOS and Android devices since the beginning, with iOS version 1.0.5 being released the latest on September 18, 2014 (which now allows support for iOS8), and earlier versions overwriting many of the graphical concerns listed above.
In fact, issues with certain versions of iOS and Android have been reported throughout the history of these mobile iterations — with the most notorious being Android 4.3 (which ultimately affected many applications on the Google Play Store).7 Due to the nature of these ever-evolving software systems, it is no wonder that this re-release was plagued the most by versioning — not just in operating system support, but also with regard to variable screen and device size. Requirements also establish that older obsolete versions of hardware and software are no longer compatible for playing the latest iteration of Chrono Trigger. On the Apple App Store, requirements state that the video game is "compatible with iPhone 4s or later" and "requires iOS 7.0 or later," while the Google Play Store requires Android 2.2 and later, along with the specification that Chrono Trigger cannot be launched on devices running Android 4.4 with Android RunTime (ART) enabled."[1][8] In fact, iPad optimization has never been fully accomplished. Ultimately, these limitations reflect the fast pace of digital technological innovation and show that even within the mobile application market, obsolete hardware and software is just as prevalent an issue.
[1] "Chrono Trigger." Apple App Store. Square Enix, 08 Dec. 2011. Web. 06 Aug. 2015.
[2] Matar, Joe. "Chrono Trigger Review: The Best RPG of the Past, Present, and Possibly Future." Hardcore Droid. Vandelay Industries, n.d. Web. 06 Aug. 2015.
[3] Haske, Steve. "Chrono Trigger Review." Mac Life. Future US, 01 Sept. 2012. Web. 06 Aug. 2015.
[4] "Bad App Reviews for Chrono Trigger." Bad App Reviews. Andy McSherry, 09 Nov. 2012. Web. 06 Aug. 2015.
[5] "Chrono Trigger Review." Slide to Play. TrouserMac Industries, 12 Dec. 2011. Web. 06 Aug. 2015.
[6] "Bad App Reviews for Chrono Trigger." Bad App Reviews. Andy McSherry, 26 April. 2013. Web. 06 Aug. 2015.
[7] Villhaver. "Square Enix's Android Software Failure." Giant Bomb. GameSpot, 5 Jan. 2014. Web. 6 Aug. 2015.
[8] "Chrono Trigger." Google Play. Google, 29 Oct. 2012. Web. 06 Aug. 2015.
This page has paths:
1 2015-06-28T01:26:00-07:00 Dene Grigar ae403ae38ea2a2cccdec0313e11579da14c92f28 Mobile iOS and Android Re-Release Madeleine Philbrook 7 Opening Page of Mobile iOS and Android re-release plain 2015-09-18T06:09:49-07:00 Madeleine Philbrook 793490c7e41f4e0efe523b50970c1632a02f214b
1 2015-06-28T01:26:00-07:00 History and Features of Chrono Trigger Mobile iOS and Android Re-Release 21 History and features of Chrono Trigger Mobile iOS and Android re-release plain 2015-09-18T06:10:08-07:00
1 2015-06-28T01:26:01-07:00 Player Traversal of the Chrono Trigger Mobile iOS and Android Re-Release 7 A collection of video files of a player interview of the Chrono Trigger mobile iOS and Android re-release plain 2015-09-18T06:10:16-07:00 January 31, 2014 1280x720 MPEG-4 Movie; H.264, AAC (codecs) Bly's Interview; Bly's Readers' Traversals & Interviews Digital Preservation with a focus on Electronic Literature Dene Grigar and Stuart Moluthrop (Co-Principal Investigators); Aaron Wintersong (Videographer); Shelley Jackson (Author/Participant) en-US Bill Bly's Traversal. (2014) [Video File]. Video File 1280x720 MPEG-4 Movie; H.264, AAC (codecs) 2015 United States of America (C,V,O,English,U,N); Pre-web (circa 1986-1995) Madeleine Brookman (Video Editor) Bly's Interview; Bly's Readers' Traversals & Interviews Researchers; Academics; Students; Teachers; Professors; Electronic Literature Enthusiasts 40:36
1 2015-06-28T01:26:00-07:00 Player Interview of the Chrono Trigger Mobile iOS and Android Re-Release 6 A collection of video files of the a player interview of the Chrono Trigger mobile iOS and Android re-release plain 2015-09-18T06:10:26-07:00 January 31, 2014 1280x720 MPEG-4 Movie; H.264, AAC (codecs) Bly's Traversal; Bly's Readers' Traversals & Interviews Digital Preservation with a focus on Electronic Literature Dene Grigar and Stuart Moluthrop (Co-Principal Investigators); Aaron Wintersong (Videographer); Shelley Jackson (Author/Participant) en-US Bill Bly's Interview. (2014) [Video File]. Video File 1280x720 MPEG-4 Movie; H.264, AAC (codecs) 2015 United States of America (C,V,O,English,U,N); Pre-web (circa 1986-1995) Madeleine Brookman (Video Editor) Bly's Traversal; Bly's Readers' Traversals & Interviews Researchers; Academics; Students; Teachers; Professors; Electronic Literature Enthusiasts 1:13:23
1 2015-06-28T01:26:01-07:00 Findings Concerning the Chrono Trigger Mobile Re-Release 9 This is the page for summarizing findings concerning the Chrono Trigger mobile re-release plain 152135 2015-09-18T06:10:33-07:00
This page references:
1 2015-07-01T15:06:29-07:00 Chrono Trigger Mobile Android Gameplay Screenshot 1 Chrono Trigger Mobile Android gameplay screenshot media/screen520x924.jpeg plain 2015-07-01T15:06:29-07:00
1 2015-07-01T16:39:40-07:00 Chrono Trigger Mobile iOS Trailer 1 Chrono Trigger mobile iOS trailer plain 2015-07-01T16:39:40-07:00
1 2015-07-01T13:59:33-07:00 Robo Screenshot 1 Robo screenshot media/chrono-trigger-nintendo-ds-042.jpg plain 2015-07-01T13:59:33-07:00
1 2015-07-01T15:05:57-07:00 Chrono Trigger Mobile iOS Gameplay Screenshot 1 Chrono Trigger Mobile iOS gameplay screenshot media/screen520x924 (1).jpeg plain 2015-07-01T15:05:57-07:00


text:
Home About Us Reports Articles Book Reviews Contact Us
Dorset County Museum, Dorchester
The Dorset County Museum was first established in 1845 by poet William Barnes and other notable local figures. The current museum building dates back to 1881 and was built on the site of the Old George Inn.
In 2018 we were invited to conduct a period of research ahead of the multi million pound refurbishments currently in progress. Our 3 nights of research were concluded within days of the doors closing on this current chapter of the museum.
A report of our findings is available including areas that we have been the last to ever document. It's been a privilege to spend time in these areas and preserve their detail for all time.
As a team we look forward to continued involvement with Dorset County Museum for many years to come.
More information about tomorrow's museum can be found here.
Contact us for more information about this report.
The Dorset Paranormal Research Team | Based in Thomas Hardy's Wessex, we are a non-profit making team focused on the study of spontaneous anomalous phenomena and ghost research | Applying rational enquiry into paranormal claims | Contact us for all enquiries.
© 2020 The Dorset Paranormal Research Team all rights reserved
Website produced by Cirrus Design Studio Dorset


The fastest, thinnest cyanoacrylate (CA) glue; sets in 10-20 seconds, viscosity similar to water allows it to wick into porous material to provide extra reinforcement in the substrate material. If you fly your planes we suggest you buy the package of 2. Put 1 bottle on your workbench and take 1 bottle into the field so you can make quick repairs. Each bottle 1/4 oz.
Medium viscosity with exceptional strength and gap filling capabilities. Sets in 15-45 seconds. Each bottle 1/4 oz.
Thick viscosity provides maximum gap filling and strength for high stress areas and laminations. 1-2 minute set time allows for repositioning. 1/2 oz. bottle.
Dave's glue of choice for applying tissue paper. Goes on blue, dries clear. .29 oz.
Dave's favorite for applying canopies and other vacuum-molded parts to your model; dries clear and stays flexible. 2 oz. bottle.
Accelerator for use with CA glues. Position and glue pieces then spray with Jet SET for an instant bond. Non-aerosol pump spray. This product cannot be shipped internationally or express. 2 oz. bottle.
SP-100 are Extra spray pumps for our accelerator.
Pro TIPS slip inside the spout for precise application of CA glues. To install, remove the spout from the bottle and cut down the tip so that the opening is large enough to slip the Pro TIP through from the inside. Feed the Pro TIP through from the inside so that the cone-shaped part fits snugly into the base of the spout and seals it off. A Pro TIP has the same diameter from its base to the tip, so that if it clogs and you have to cut it down, it will still apply the glue just as precisely. Each box comes with 12 Pro TIPS.
These TIPS are fine bore, clog resistant nozzle extensions for precise CA application. Tips are cut on an angle and release 1 drop at a time. Jet TIPS fit INSTANT, SUPER, or SLOW glues. Box of 6.
The Jet PAK includes 12" of capillary tubing, 5 TIPS, and 1 spare cap which fits all sizes of Jet CA glues.
Super Solvent is a debonder and cleaner for any CA glue. Super Solvent does not contain acetone. It works faster and is more pleasant to use than acetone-based debonders. This product cannot be shipped internationally or express. 2 oz. bottle.


The Publican Awards, in association with Sky, have been held now for the past 6 years and within that time is has become the biggest event in the pub industry's calendar. The Awards celebrate the achievements of the leading pub companies across a range of categories that reflect the products and services on offer across the British Pub Estate; it's basically the pub equivalent of the Oscars.
CPL Training sponsored the event this year and they will continue to do so for the next two years. More than 1,100 people attended the 2013 ceremony held at the Grosvenor House Hotel on London's Park Lane, which was hosted by comedian and TV star Rob Brydon. The Awards have previously been held by the likes of Jimmy Carr, Alan Car and Justin Lee Collins.
Daniel Davies, CEO of the CPL Training Group and one of the judges from the night, said: "The Publican Awards is always a great event to be a part of; it gives people the opportunity to network with key industry pubco figures and build invaluable relationships with them. It also gives people the chance to launch new brands and to become associated with a leading corporate event. Plus, it's always good fun and supplies great food and drink! I'm already looking forward to next year's awards."
CPL would just like to say congratulations to everyone who was nominated at the Awards and good luck for 2014!


text:
Sex is the second extended play (EP) by English band the 1975. It was released on 19 November 2012 by Dirty Hit. A modified version was released in the US on 1 January 2013 by Dirty Hit and Polydor Records. The band produced the EP alongside Michael Coles, Robert Coles and Mike Crossey. They drew musical inspiration from Sigur Rós, Brian Eno and filmmaker John Hughes while thematically focusing on the passage of time. Prior to the record's debut, a music video for "Sex" was released.

An ambient rock-influenced rock, R&B, electro, pop and emo record, Sex is musically divided into two halves. Its first half is characterised by its ethereal compositions which draw from electropop, while the second half is informed by an extensive use of guitars. The record's lyrics incorporate themes of love, sex and drugs. Upon release, the EP received generally mixed reviews from contemporary music critics, who praised the exploration of various genres but felt the record suffered from a lack of cohesion.

Development and release

In January 2012, the 1975 was formed by singer Matthew Healy, drummer George Daniel, guitarist Adam Hann and bassist Ross MacDonald, who had played music together since 2002. After being rejected by all major record labels, artist manager Jamie Osborne discovered the band and signed them to his label Dirty Hit. The 1975 began a process of releasing three extended plays (EP) leading to their debut album. In August of the same year, the band released their debut EP, Facedown, to critical success. To aid in developing the follow-up record, Sex, the 1975 approached Mike Crossey, who provided additional production and mixing on "Sex" and "You". In addition to working with producers Michael and Robert Coles, the band self-produced "Intro/Set3".

Regarding the creative process behind Sex, Healy said: "We were planning on putting out [the EPs] with absolutely no intention of them being accepted in the way they have. We kind of got used to being in really underground bands - where the world of mainstream radio and media just seems so genuinely far away." The 1975 drew inspiration from Sigur Rós, ambient musician Brian Eno and filmmaker John Hughes. The singer noted that his affection for ambient music stems from the genre's use in movies, which he enjoyed at a young age, saying it "commands you how to feel without the use of words". Discussing the overall theme of the EPs, Healy said they were focused on sex, love, drugs and fear, while also noting: "The songs on Sex are all about passing moments. Moments that we don't analyse at the time – only to understand them retrospectively." A music video for "Sex" was released on 5 October 2012, while the EP was released by Dirty Hit on 19 November 2012. A different version of Sex containing a modified tracklist was released in the US on 1 January 2013 by Dirty Hit and Polydor Records.

Composition

Music and lyrics
Exploring ambient rock concepts, Sex combines rock, R&B, electro, pop and emo music, while the lyrics deal with themes of love, sex and drugs. Writing for Hit the Floor Magazine, Amy Jones said that in contrast to Facedown, Sex contains a "slightly darker [and] more foreboding" tone, while Paste writer Shaina Pearlman observed "equal parts ethereal and synth pop" throughout the record. Amanda Koellner of Consequence identified two distinct sounds within Sex. She described the first as recalling the "intricate electropop" of Passion Pit's "more mellow songs". Koellner wrote that "Sex" marks the EP's sonic shift from a "companionless headphone" record to the "centre of a party", characterised by "traditional" guitar-heavy compositions. DIYs Martyn Young shared this opinion and said the EP is "arbitrar[ily] split between the first two overtly electronic hazy pop songs and the second two "more straightforward traditional guitar tracks". QRO Magazine writer Robin Sinhababu noted that Sex is composed of four different styles of British emo.

Songs

"Intro/Set3", an electronic, R&B and pop slow jam, opens Sex with "glitching" layers instruments and effects, electronic synth beats and tiered vocals which utilise a "cut up vocal effect". The song gradually builds until reaching a plateau in its mid-section. A "hazy" and "futuristic" 1990s-style electronic, R&B and pop slow jam, "Undo" contains electronic synths and elements of chillwave, indie and acoustic. "Sex" is an indie rock, indie pop and emo-rock song. Drawing from pop-punk, Britpop and power pop, the production features minimal synths and a post-rock-influenced middle eight. Lyrically, the song is about spontaneous sexual intercourse ("But if we're gonna do anything we might as well just fuck") while Healy repeats the hook: "She's got a boyfriend anyway".

Incorporating elements of shoegaze, "You" is a guitar-heavy ballad that begins with gentle and quiet distorted guitars as Healy sings: "You're a liar / At least all of your friends are". As the song continues to build, subtle drums are added at the 40-second mark while Healy sings the hook: "It takes a bit more than you". Thematically, Healy said the track was inspired by the dissolution of his social group, noting it represents "that moment when you realise, [']Oh, that was a bit of a waste of time--but fuck it, I'm actually just as happy as I was before so no harm done[']". "Milk" is a hidden track that occupies the final two minutes and twelve seconds of "You". It is a guitar-heavy pop rock and indie song containing elements of electro and shoegaze, while the lyrics deal with drugs and sex. "Head.Cars.Bending (George Daniel Remix)" is an electronic and dance song that incorporates elements of UK garage. The song's original version was later released on the 1975's third EP, Music for Cars (2013).

Critical reception
Awarding Sex a score of 9 out of 10, Amy Jones commended the EP's musical diversity and its development of the 1975's signature sound, asserting the record shows promise for the band's debut album. In addition to praising the title track as a highlight from the EP, she wrote: "Every track on this is incredible and shows off the band's spectrum of talents with ease and simplicity." Pearlman lauded the diversity of genres on Sex, writing that while it did not appear entirely cohesive at first, repeated listens helped the EP "[come] together remarkably well". She was particularly favourable toward the second half of the record, writing that the 1975 excel on pop-oriented songs such as "Sex" and "You", the latter of which she deemed as "undoubtedly the standout". Norman Fleischer of Nothing but Hope and Passion praised the variety of styles present on the EP and deemed the title track an "obvious hit single", writing that the band "stick[s] up to the expectations" set by fellow Manchester musicians.

Martyn Young awarded Sex three out of five stars; asserting that while the record showed "a great deal of promise"—with the exception of "You", which he opined ends the EP on a disappointing note—he struggled to understand "exactly who [t]he 1975 are", owing to the band's "wildly fluctuating" sound. Amanda Koellner gave Sex a grade of C−. She commended the 1975's exploration of different styles and called the EP a "fun listen with lots to offer". However, she felt it was "apparent that The 1975 are still searching for their sound" and criticised the transition from the first half of the record to the second, comparing it to "an accidental click of the shuffle button". In a negative review, Robin Sinhababu gave the EP a score of 3.5 out of 10. Despite praising the "dynamic" sound of "You", she called Healy a nuisance and criticised the record's overtly sexual nature, saying the singer "whines melodramatically about all kinds of things, from the irrelevant to the trivial".

Track listing

Later digital editions of Sex replace the 19 minutes of silence with just under 3 minutes; this version is 9:52 in length and "Milk" begins at 7:36.

Notes
  signifies an additional producer
 On the standard version, "Sex" is alternatively titled "Sex - EP Version"
 "Head.Cars.Bending (George Daniel Remix)" is alternatively titled "Head.Cars.Bending (The 1975 Remix)"

References

2012 EPs
The 1975 EPs
Vagrant Records albums
Rock EPs
Contemporary R&B EPs
Electro albums by English artists
Pop music EPs
Emo EPs

redpajama_set_name: RedPajamaWikipedia


While there might be other factors in your decision, total cost, ease of installation, and reliability are among the most important to consider.
First let's consider what's about the same. Energy savings between new and retrofit are the same. Rebates for new fixtures tend to be higher than for the retrofits. New LED high bays have come down in price in recent years while the efficiency has gone up. So, the difference in price between new or retrofit is negligible. Get a quote.
Really, the most important costs to consider are the installation costs. The time it takes your electrician(s) to install will likely be the biggest difference in the total cost of the project. That's why ease of installation is an important aspect.
Unlike outdoor parking lot fixtures, new high bay fixtures typically take one person to install, it's nearly as simple as removing the old fixture and completely replacing it with the new one. Whereas a retrofit high-bay may take two people because you must remove the ballast and the time that it takes to physically perform the work can be 2-3 times longer than a new replacement. Multiply that by the number of fixtures and you may have a significant difference in cost.
So, if ease of installation is your primary concern, choose new LED high-bays.
New high-bays or retrofits from MyLEDLightingGuide provide reliable light. They all come with at least 5-year warranties. They use the same, reliable drivers – Mean Well, Inventronics, or Philips.
So, where do the reliability differences begin? They are mostly in the existing fixture.
Evaluate the condition of the current fixtures. Are the lenses yellow? Is there rust? How durable are they? If their condition is not good enough to last another 5-10 years, then consider buying new. The new high-bay fixtures MyLEDLightingGuide offers are rugged but compact. They have an epoxy coating to make them tougher. They don't need reflectors and you have choices in optics and features.
If your current fixtures have a custom design and they are in good condition, or you just like the look of them better than the new available options, then retrofitting may be a good choice for you.
Overall, when we consider the total cost, ease of installation, and reliability, purchasing new LED high-bays is the better option.


text:
thelineup
'Grease':
Attention Soul Patrol. Here's a chance to see American Idol winner Taylor Hicks up close and personal - he performs the part of Teen Angel in Grease, the perennial crowd-pleaser set in the 1950s. Hicks will only appear during the first week of the run, Tuesday-Feb.8. The musical runs Tuesday-Feb. 15 at the France-Merrick Performing Arts Center, 12 N. Eutaw St. Showtimes vary. Tickets cost $22-$67. Call 410-547-7328 or go to france-merrickpac.com.
Mary Carole McCauley
'Unraveling the Nest':
Unraveling the Nest, a series of prints by artist Debra Rubino, runs through Feb. 22 at Stevenson University, 1525 Greenspring Valley Road in Stevenson. The artist will talk about her work at noon Tuesday. Go to stevenson.edu.
Edward Gunts
'Band of Outsiders':
Jean-Luc Godard and John Waters share a love for the dance craze called the Madison. Waters made it a centerpiece of Hairspray, and Godard asked Claude Brasseur, Sami Frey and Anna Karina to perform their own version of it in his oddly humorous and tender film noir, Band of Outsiders. The charming movie plays at noon Saturday ($6) and 7 p.m. Monday ($8) at the Charles Theatre, 1711 N. Charles St. Call 410-727-3456 or go to thecharles.com.
Michael Sragow
Roy Ayers:
After James Brown, Roy Ayers is the most-sampled artist in hip-hop. Throughout his 40-plus years of recording, the legendary vibraphonist and singer-songwriter has pushed the sonic boundaries of jazz, R&B;, funk and pop. His visionary, brilliantly syncopated '70s classics help set the musical template for hip-hop and neo-soul. Ayers performs at 8 and 10 tonight through Saturday at Blues Alley, 1073 Wisconsin Ave. N.W. in Washington. Tickets cost $35. Call 202-337-4141 or go to bluesalley.com.
Rashod D. Ollison
de Ryke and Schlosberg:
Fans of song recitals, and those leery of them, should find much to enjoy when engaging baritone Ryan de Ryke, accompanied by excellent pianist Daniel Schlosberg, explores works by the great British composer Vaughan Williams and others. The recital is at 8 p.m. tomorrow at An die Musik, 409 N. Charles St. Tickets are $12 and $15. Call 410-385-2638 or go to andiemusiklive.com.
Model Train Show :
Take the kids to see the model trains at the Great Scale Model Train Show this weekend at the Maryland State Fairgrounds. See operating model layouts and browse 750 tables of merchandise. The show runs 9 a.m.-4 p.m. Saturday and 10 a.m.-4 p.m. Sunday at the fairgrounds, 2200 York Road, Timonium. Admission is $9 per person or $18 per family; kids younger than 15 are admitted free. Show your hand stamp from Saturday and get in free Sunday. Call 410-730-1036 or go to gsmts.com.
Kate Shatzkin


text:
APA Style Help Center
Visual Guide
Citing References in Text
References Page
APA Style Guide
Citation and formatting assistance for research papers written in APA Style.
One Author
Two to Five Authors
Six Authors or More
Multiple Sources
Personal Communication
Secondary Citation
Paraphrased
Direct Quotation
No Page Numbers
(Author, Year, Location)
(Abel, 2015, p. 10)
Start with the author's last name, or, if there isn't one, with the title. The in-text citation should lead directly to the citation in the Reference list.
The in-text citation immediately follows the idea (Abel, 2015) without waiting for the end of the sentence.
You might also use the author in your narrative, in which case you need not repeat it in the parentheses. You will still have the date if you are paraphrasing or summarizing (2015) or date and page number for a direct quote (2005, p. 10). According to Abel, there is no need to worry (2015, p. 10).
For more information, see the Publication Manual of the American Psychological Association, p. 174
(Author, Author, Author, Author, & Author, Date, Location)
Five authors or less should all be cited in the parentheses. They should all remain in the order that they appear on the title page.
"Test anxiety strongly correlated with the perceived imbalance between efforts spent and rewards received" (Hahn, Kropp, Kirschstein, Rucker & Muller-Hilke, 2017, p. 1).
If you cite it another time, you can use the first author, et al.
"Test anxiety is higher before oral than before written exams" (Hahn et al., 2017, p. 9).
For more information, see the Publication Manual of the American Psychological Association, p. 175
(Author, et al., date, location)
Six or more authors, use et al. even for the first in-text citation. Et al. means "and others."
(Franco, et al, 2015, p. 12).
(Corporate Author, date, location)
Use the full name of the corporation as given on the title page.
(Pew Research Center, 2015, para. 4)
Corporate author commonly known by an acronym – Use the full name the first time but give the acronym in brackets
(American Psychological Association [APA], 2016).
If you cite it another time, just use the acronym
(APA, 2016).
(Title, date, location)
No author, use the first word or words in the citation. If it is an article title, use plain font.
(Bipolar, 2015, p. 17).
If the source is a book and title is in italics, use italics here as well
(Merck, 2016, p. 342)
For more information, see the Publication Manual of the American Psychological Association, p. 176-177
You could have several citations within the same sentence.
Zika virus prevention may include vaccination (Lowy, 2015), pesticide use (Pepin & Penn, 2017), or elimination of standing water (Likas, et al, 2016).
Or you might have several references within the same parentheses.
Scientists agree that prevention is the key to eliminating the Zika virus (Likas, et al, 2016; Lowy, 2015; Pepin & Penn, 2017).
For more information, see the Publication Manual of the American Psychological Association, pp. 175 & 177-178
(Name, personal communication, date)
Personal communication such as an interview, email, or telephone conversation will have an in-text citation but will not appear in the References list. Only items that can be retrieved appear in the list. Use the person's initials as well as surname.
(J. Bond, personal communication, April 1, 2010).
(as cited in Author, date, location)
Secondary citation is when you are quoting an author who quoted another source.
It is always preferable to go directly to the original source when possible. If you cannot locate the original source, give credit indirectly. Your in-text citation will still lead to the appropriate item in the reference list.
Ben Franklin wrote that "It was in everyone's interest to be virtuous if he wished to be happy in this world," (as cited in Dillon, 2009, p. 41).
The Federal Bureau of Investigation reports that 23.5% of the 511 officers were killed while making an arrest (as cited in Evans, 2016, p. 79).
Paraphrased – when you use your own words to express an author's ideas, it is still best to give page numbers. If there are no page numbers, count the paragraphs and give the paragraph number. If there is a section title, give that as well.
The pay gap between men and women is less among ages 25-34 (Brown, A., 2017, para. 3)
However, there are times when that is not feasible, such as when summarizing the author's premise.
The pay gap between men and women is is narrowing but still persists (Brown, A., 2017).
If you use the author's name in your narrative, start the in-text citation with the date.
According to Brown, the pay gap between men and women aged 25-34 has decreased to 10% (2017, para. 3).
A direct quotation is when you use the exact words from your source.
If the quotation is fewer than forty words, put it in quotation marks. The in-text citation will follow the quotation marks even if it is in the middle of a sentence.
The Mongols had the resources to conquer much of Europe and Asia because "they enjoyed an unprecedented, and yet-to-be-repeated, 15-year run of bountiful rains and mild weather" (Smith, 2014, para. 2), yielding an abundance of resources.
If the quotation is forty words or more, format it as a block of text 1/2 inch in from the left margin. The in-text citation will come at the end of the block quote.
New research by tree-ring scientists from Columbia University's Lamont-Doherty Earth Observatory and West Virginia University may have uncovered the reason why an obscure band of nomadic Mongol horsemen was able to sweep through much of Asia in a few meteoric decades 800 years ago, conquering everything in their path: They enjoyed an unprecedented, and yet-to-be-repeated, 15-year run of bountiful rains and mild weather on the normally cold and arid steppes (Smith, 2014, para. 2).
For more information, see the Publication Manual of the American Psychological Association, pages 92 and 170-172.
If there is a page number, use it.
(Torpey, 2015, p. 57)
No page number – Use a section name and count paragraphs.
(Torpey, 2017, Associate's degree, Table 1)
(Torpey, 2017, Bachelor's degree, para. 2)
No section name – count paragraphs.
(Torpey, 2017, para. 3)
For more information, see the Publication Manual of the American Psychological Association, pp. 171-172.
Reference Citation Examples
This page is from the APA Style LibGuide created by your LSC-Kingwood Librarians.
<< Previous: Information & Resources
Last Updated: Nov 8, 2021 4:32 PM
URL: https://kwlibguides.lonestar.edu/respiratory-therapy
Subjects: Health Occupations


If a cool, fresh look is what you want in the bedroom then the Petworth door in Legno Linen is the perfect choice for you. This crisp, unfussy design will make even the cosiest of rooms look spacious, and the clean, bright colour adds light. This door can be created in any size you need, so no need to worry if you've got a room with awkward angles. Our made-to-measure service gives you a custom-built feel for a fraction of the cost.
The Petworth door is one of our handleless options and this makes it ideal for a minimalist bedroom. The door has a plain front with a simple cut-out along one edge for easy opening. This look is repeated on the drawer front with the cut-out along the upper edge of the drawer front. You'll save money on the purchase of handles, and what's more, these doors are incredibly easy to look after and keep clean.
The colour of Legno Linen is ideal for the Petworth bedroom door. The simplicity of the door's design allows the fresh, crisp white colour to take centre-stage, while the woodgrain finish adds a touch of texture and rustic charm. This painted-wood effect is easy to accessorise - so whether you want a modern monochrome look, or something a little more luxurious, you'll have no problem pairing this door with your choice of soft furnishings. The Petworth handleless bedroom door in Legno Linen is the ideal partner for your bedroom decor.


The larynx is the voicebox. It is in the neck, above the windpipe (trachea) and in front of the gullet (oesophagus). The windpipe is the tube that takes air to and from the lungs. The gullet is the tube that food goes down when you eat. The larynx is tube-shaped and about 5cm (2in) long.
The larynx allows the air you breathe to reach your lungs. It has a flap of skin at the top, called the epiglottis. This directs food and liquid down the gullet and prevents food and drink from going into the windpipe when you swallow. The larynx contains the two vocal cords, which vibrate together when air passes between them to produce the sound of your voice.
The front of the larynx can be seen or felt as the lump in the front of the neck known as the Adam's apple.
subglottis – the area below the vocal cords that connects to the windpipe.


text:
Rule Title: COMPLAINT
24.26.680 COMPLAINT (REPEALED)
History: 39-31-104, MCA; IMP, 39-31-406, MCA; NEW, Eff. 6/4/74; AMD, 1993 MAR p. 3026, Eff. 1/1/94; AMD, 2010 MAR p. 2841, Eff. 12/10/10; AMD, 2018 MAR p. 1602, Eff. 8/11/18; REP, 2020 MAR p. 2422, Eff. 12/25/20.
24-26-353 12/25/2020 Current History: 39-31-104, MCA; IMP, 39-31-406, MCA; NEW, Eff. 6/4/74; AMD, 1993 MAR p. 3026, Eff. 1/1/94; AMD, 2010 MAR p. 2841, Eff. 12/10/10; AMD, 2018 MAR p. 1602, Eff. 8/11/18; REP, 2020 MAR p. 2422, Eff. 12/25/20.
24-26-336 8/11/2018 12/25/2020 History: 39-31-104, MCA; IMP, 39-31-406, MCA; NEW, Eff. 6/4/74; AMD, 1993 MAR p. 3026, Eff. 1/1/94; AMD, 2010 MAR p. 2841, Eff. 12/10/10; AMD, 2018 MAR p. 1602, Eff. 8/11/18.
24-16-248 12/10/2010 8/11/2018 History: 39-31-104, MCA; IMP, 39-31-406, MCA; NEW, Eff. 6/4/74; AMD, 1993 MAR p. 3026, Eff. 1/1/94; AMD, 2010 MAR p. 2841, Eff. 12/10/10.


text:
Q: .gitignore still tracking files even if I tried to ignore them, why? I have the following directory structure in a project:
.
├── application
│   ├── ... <more folders & files goes here>
├── config
├── cronjobs
│── ... <more folders & files goes here>
├── oneview_symfony
│   ├── app
│   ├── bin
│   ├── src
│   ├── tests
│   ├── var
│   ├── vendor
│   └── web
├── .gitignore

I am trying to ignore some files and folders and this are the rules I have in my .gitignore file:
oneview_symfony/app/cache/*
oneview_symfony/app/logs/*
!oneview_symfony/app/cache/.gitkeep
!oneview_symfony/app/logs/.gitkeep

oneview_symfony/app/spool/*

oneview_symfony/var/cache/*
oneview_symfony/var/logs/*
oneview_symfony/var/sessions/*
!oneview_symfony/var/cache/.gitkeep
!oneview_symfony/var/logs/.gitkeep
!oneview_symfony/var/sessions/.gitkeep

oneview_symfony/app/config/parameters.yml
oneview_symfony/app/config/parameters.ini

oneview_symfony/app/bootstrap.php.cache
oneview_symfony/var/bootstrap.php.cache
oneview_symfony/bin/*
!oneview_symfony/bin/console
!oneview_symfony/bin/symfony_requirements
oneview_symfony/vendor/*

oneview_symfony/web/bundles/
oneview_symfony/web/uploads/
oneview_symfony/app/phpunit.xml
oneview_symfony/phpunit.xml
oneview_symfony/build/

oneview_symfony/web/css/
oneview_symfony/web/js/

Having the info above if I run git status I am still seeing files under oneview_symfony/vendor/, why? What I am missing?
Output example for the command above:
    ...
    new file:   oneview_symfony/vendor/zendframework/zendframework1/resources/languages/pt_BR/Zend_Validate.php
    new file:   oneview_symfony/vendor/zendframework/zendframework1/resources/languages/ru/Zend_Validate.php
    new file:   oneview_symfony/vendor/zendframework/zendframework1/resources/languages/sk/Zend_Captcha.php
    new file:   oneview_symfony/vendor/zendframework/zendframework1/resources/languages/sk/Zend_Validate.php
    new file:   oneview_symfony/vendor/zendframework/zendframework1/resources/languages/sr/Zend_Validate.php
    new file:   oneview_symfony/vendor/zendframework/zendframework1/resources/languages/uk/Zend_Validate.php
    modified:   oneview_symfony/web/.htaccess

Changes not staged for commit:
  (use "git add <file>..." to update what will be committed)
  (use "git checkout -- <file>..." to discard changes in working directory)

A: You have already added these files into your git repo and/or staged the changes.
To remove them from the repo, you can run git rm -r --cache <folder-to-ignore> to remove them from the git cache. (Make sure to include the --cache flag so that it doesn't delete the actual files too!)
If you've simply staged the files, you can instead run git reset to unstage them, and they should stop appearing in the changes list if they've been added to the .gitignore correctly.

redpajama_set_name: RedPajamaStackExchange


Among the numerous tree-planting programs the company supports through funding and volunteerism, this fall Entergy sponsored an energy-saving tree giveaway program in partnership with the Arbor Day Foundation. Entergy customers were encouraged to sign up to receive a free tree and help improve their community. By planting trees in the right places, homeowners can effectively shade their homes and save money on their energy bills each month. In addition, planting the right types of trees helps communities large and small improve energy efficiency, provides protection from damaging wind gusts, and creates cleaner air, water and carbon benefits.
Entergy has a longstanding partnership with The Arbor Day Foundation. In 2018, the organization recognized Entergy for the 13th year as a "2018 Tree Line USA" in honor of its commitment to proper tree pruning, planting and care in the company's service area.


He enjoys being able to get Showtime to add exciting technology dimensions to the current Indian Government's initiatives in several fields.
A deeply Christian upbringing and a solid grounding in Christian values embedded through one of India's best-known Catholic schools of the time, St Columba's in Delhi and inspired by the Irish Christian Brothers who ran the school and three maternal uncles who were Catholic priests might well have seen a young impressionable Michael opt to join a religious order very early in life! If it had not been for his father insisting that he put off his decision till he finished College. A degree in Economics from the venerable St Stephen's College followed and opened up a whole, new world from which it seems Michael never looked back!
"I certainly didn't realize at that time that my Dad – a strict, no-nonsense, honest Government servant – would have such a great influence in changing the course of my life!". But I must admit that even today, it is those Christian values and a deep faith in God that is the driving force of my life!!!
After a formative 5 years at the Usha Sales unit of the Shriram Group acknowledged then as the finest management training program in the corporate world that led to a providential career-direction into the exciting world of advertising, the entrepreneurial bug had already seemed to have embedded itself in Michael. And December 1979 saw Michael launch his own advertising agency, Maadhyam, with a strong backing from consumer-durable and realty major, DLF where he had done a brief stint after his assignment at Usha and tractor-major Eicher Goodearth with whom he had developed a great working relationship and respect for, during another stint that he took on with a medium-sized advertising agency to learn the agency ropes before he branched out on his own. Maadhyam soon built a reputation as a boutique agency that actually played a major role in the marketing and branding of what is still the country's largest real estate development, DLF City! With some truly path-breaking campaigns for an industry that had never seen professional marketing efforts of such consequence. Maadhyam, in fact, actually built the gold standard for real estate marketing not just in India but to non-resident Indians located all over the world. Over the years, Maadhyam added blue-chips like the world's largest motorcycle manufacturer, Hero Honda and international airline major, KLM to build an impressive profile. A profile that interested agency conglomerates enough to enable Michael to exit at a time when he decided it was time to move on to another more exciting medium of communication and entertainment.
It was no wonder then that Showtime became the agency of choice for the corporate world. It launched every 2-wheeler for Hero and almost every new car that hit the Indian roads, beginning from the small-car trio – the Hyundai Santro, the Daewoo Matiz and the Tata Indica in the late 90s to the whole range of models that came out of these stables over the early part of this century to the entire Fiat range, the Volkswagen Polo and Vento and a whole set of ultra-luxury sedans and SUVs for BMW. Showtime also worked extensively with the Tata Group – the Taj Hotels for whom the 100 Years of the Taj event was a game-changing signature event, Tata Motors, TCS and Tata Global Beverages for whom the Starbucks launch in India was another landmark event remembered fondly even today. Michael also worked closely with the Confederation of Indian Industry (CII) to take Brand India across the world through signature events at the WEF in Davos every year since 2006, the Hannover Messe and India@60 in New York where Showtime did a nerve-wrangling 42 events in 3 days across the city.
Michael has now passed on the Showtime baton to his son, Avik who is adding new dimensions to his father's path-breaking endeavors. Michael himself now plans to devote a lot of his time to give back to the industry, by playing a larger role in the apex event industry body he helped found, particularly in building relationships with design and management institutes to develop specific skill-building courses and initiatives, that could make it future-ready for the digital century that the event world is still coming to terms with.
He is also enjoys being able to get Showtime to add exciting technology dimensions to the current Indian Government's initiatives in several fields. The pivotal role played by Showtime in driving India's presence at the recent Climate Change Summits in Paris and Marrakesh and closer home in the Startup India initiative have only whetted his appetite and he hopes to make a major contribution in other critical Government endeavors soon. He is also active in supporting CSR initiatives that Showtime should and could contribute meaningfully to today. A recent experience of working for a project for the differently-abled community run with the support of the Tata Trusts and his mentor from the time he worked with him, Mr. RK Krishna Kumar, the erstwhile Managing Director of Tata Hotels, and his wife, Ratna has had a deep and abiding impact on him and he hopes he can extend this kind of support to many more similar initiatives.
Took Brand India across the world through signature events at the WEF in Davos every year since 2006.
Landmark event – Starbucks launch in India.