text:
'''
Finds the cheapest fares filed FROM a given city

Example:
    python destination_finder.py SFO -l 0 -hf 300 -n 1

Result:
    LAS  $66.20    B6       2016-04-12 to 2016-04-12
'''

import datetime
import json
import sys
import argparse
import random

sys.path.append('..')
import sabre_dev_studio
import sabre_dev_studio.sabre_exceptions as sabre_exceptions
import sabre_dev_studio.sabre_utils as sabre_utils

'''
requires config.json in the same directory for api authentication

{
	"sabre_client_id": -----,
	"sabre_client_secret": -----
}

'''

def read_config():
    raw_data = open('config.json').read()

    data = json.loads(raw_data)

    client_secret = data['sabre_client_secret']
    client_id = data['sabre_client_id']

    return (client_id, client_secret)

def set_up_client():
    # Read from config
    client_id, client_secret = read_config()
    sds = sabre_dev_studio.SabreDevStudio()
    sds.set_credentials(client_id, client_secret)
    sds.authenticate()
    return sds

def convert_date(d):
    if d is not None:
        return datetime.datetime.strptime(d, '%m-%d-%Y')
    else:
        return None

def parse_args(argv):
    city = sys.argv[1]
    try:
        point_of_sale = sys.argv[2]
    except:
        point_of_sale = 'US'
    return (city,point_of_sale)

def main():
    parser = argparse.ArgumentParser(description='Get destinations and fares given certain parameters.')
    parser.add_argument('origin', type=str, help='departure city code')
    parser.add_argument('-nu', '--no-unique', action='store_true',
                        help='will return duplicate cities in results', default=False)
    parser.add_argument('-n', '--num-results', type=int,
                        help='number of results to return', default=10)
    parser.add_argument('-s', '--sort-by', type=str,
                        help='which parameter to sort results by', default='price',
                        choices=['price', 'cpm', 'random'])
    parser.add_argument('-a', '--airline', type=str, nargs='*',
                        help='airline codes to search', default=None)
    parser.add_argument('-al', '--alliance', type=str,
                        help='airline alliance to search', default=None,
                        choices=['oneworld', 'star', 'skyteam'])
    parser.add_argument('-d', '--destination-city', type=str,
                        help='destination city code', default=None)
    parser.add_argument('-l', '--length-of-stay', type=int,
                        help='length of stay at destintation', default=[0], nargs='+')
    parser.add_argument('-pm', '--plus-or-minus', type=int,
                        help='if single length of stay is specified, searches within this margin (e.g. if length of stay is 3, and this value is 2, it\'ll search for length of stay values 1, 2, 3, 4, and 5)',
                        default=0)
    parser.add_argument('-cpm', '--cost-per-mile', type=float,
                        help='fare cost per mile', default=None)
    parser.add_argument('-ps', '--point-of-sale', type=str,
                        help='point of sale country', default=None)
    parser.add_argument('-lf', '--lowest-fare', type=int,
                        help='minimum fare to return', default=None)
    parser.add_argument('-hf', '--highest-fare', type=int,
                        help='maximum fare to return', default=None)
    parser.add_argument('-r', '--region', type=str,
                        help='region to search', default=None,
                        choices=['Africa',
                                 'Asia Pacific',
                                 'Europe',
                                 'Latin America',
                                 'Middle East',
                                 'North America'],
                        nargs='*')
    parser.add_argument('-t', '--theme', type=str,
                        help='region to search', default=None,
                        choices=['beach', 'disney', 'gambling', 'historic',
                                 'mountains', 'national-parks', 'outdoors',
                                 'romantic', 'shopping', 'skiing',
                                 'theme-park', 'caribbean'],
                        nargs='*')
    parser.add_argument('-c', '--country', type=str,
                        help='only returns results from this country code',
                        default=None)
    parser.add_argument('-dd', '--departure-date', type=str,
                        help='earliest departure date (MM-DD-YYYY)',
                        default=None)
    parser.add_argument('-rd', '--return-date', type=str,
                        help='earliest return date (MM-DD-YYYY)',
                        default=None)
    parser.add_argument('-edd', '--earliest-departure', type=str,
                        help='earliest departure date (MM-DD-YYYY)',
                        default=None)
    parser.add_argument('-ldd', '--latest-departure', type=str,
                        help='latest departure date (MM-DD-YYYY)',
                        default=None)
    args = parser.parse_args()

    client = set_up_client()

    # Map airline alliance to Sabre's unintuitive code
    if args.alliance:
        if args.alliance == 'star':
            alliance = '*A'
        elif args.alliance == 'oneworld':
            alliance = '*O'
        elif args.alliance == 'skyteam':
            alliance = '*S'

        # Look up airlines
        res = client.alliance_lookup(alliance)
        airline_data = res.alliance_info[0].airline_info
        airline_codes = map(lambda rd: rd.airline_code, airline_data)
        if args.airline:
            args.airline += airline_codes
        else:
            args.airline = airline_codes

    # Look up city
    city_resp = client.country_code_lookup(args.origin)

    if not city_resp:
        print("Invalid city/airport code.")
        sys.exit(0)

    if not args.point_of_sale:
        pos = city_resp
    else:
        pos = args.point_of_sale

    if len(args.length_of_stay) == 1 and args.plus_or_minus:
        los = args.length_of_stay[0]
        pm = args.plus_or_minus
        length_of_stay = list(range(max(los - pm, 0),
                                    los + pm))
    else:
        length_of_stay = args.length_of_stay

    try:
        resp = client.destination_finder(args.origin,
                                         destination=args.destination_city,
                                         length_of_stay=length_of_stay,
                                         point_of_sale=pos,
                                         departure_date=convert_date(args.departure_date),
                                         return_date=convert_date(args.return_date),
                                         latest_departure_date=
                                         convert_date(args.latest_departure),
                                         earliest_departure_date=
                                         convert_date(args.earliest_departure),
                                         min_fare=args.lowest_fare,
                                         max_fare=args.highest_fare,
                                         region=args.region,
                                         theme=args.theme,
                                         location=args.country,
                                         cost_per_mile=args.cost_per_mile)
    except sabre_exceptions.SabreErrorNotFound:
        print("No results found.")
        sys.exit(0)

    prices = []
    fares = resp.fare_info
    for fare in fares:
        if fare.lowest_fare != 'N/A':
            prices.append((fare.destination_location,
                           fare.departure_date_time,
                           fare.return_date_time,
                           fare.lowest_fare.fare,
                           fare.lowest_fare.airline_codes,
                           fare.price_per_mile))

    if args.sort_by == 'price':
        sorted_prices = sorted(prices, key = lambda x: x[3])
    elif args.sort_by == 'cpm':
        sorted_prices = sorted(prices, key = lambda x: x[5])
    else:
        sorted_prices = prices
        random.shuffle(sorted_prices)

    count = 0
    cities = {}
    for price in sorted_prices:
        if count >= args.num_results:
            break

        airlines = price[4]

        if not args.airline:
            airline_valid = True
        else:
            intersection_airlines = set(airlines).intersection(args.airline)
            airline_valid = len(intersection_airlines)

        if args.no_unique:
            uniqueness_valid = True
        else:
            uniqueness_valid = cities.get(price[0]) is None

        if airline_valid and uniqueness_valid:
            price_round = '%.2f' % price[3]
            cpm_round = '%.2f' % price[5]

            if args.sort_by == 'cpm' or args.cost_per_mile:
                fstring = "{0:4} ${1:8} {2:4} cpm    {3:10} {4} to {5}"
                out_str = fstring.format(price[0],
                                         price_round,
                                         cpm_round,
                                         ' '.join(airlines),
                                         price[1].split('T')[0],
                                         price[2].split('T')[0])
            else:
                fstring = "{0:4} ${1:8} {2:10} {3} to {4}"
                out_str = fstring.format(price[0],
                                         price_round,
                                         ' '.join(airlines),
                                         price[1].split('T')[0],
                                         price[2].split('T')[0])

            count += 1
            cities[price[0]] = True
            print(out_str)

    if count == 0:
        print("No results found.")

if __name__ == '__main__':
    main()

redpajama_set_name: RedPajamaGithub


text:
High-Dose Corticosteroid Therapy for Erlotinib-Induced Interstitial Lung Disease in Japanese Patient with Advanced Pancreatic Cancer
Masato Yoshioka1*, Go Watanabe1, Hiroshi Uchinami1, Norihito Ise1, Yasuhiko Nakagawa1, Kazuhiro Kudoh1, Ryo Morita2, Hideaki Andoh1 and Yuzo Yamamoto1
1Department of Gastroenterological Surgery and 2Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan
Department of Gastroenterological Surgery
Akita University Graduate School of Medicine
1-1-1 Hondo, Akita 010-8543, Japan
Received August 18th, 2014 – Accepted October 25th, 2014
Context Erlotinib is a selective epidermal growth factor receptor tyrosine kinase inhibitor used as a target therapy against non-small lung cancer and advanced pancreatic cancer. A regimen of erlotinib plus gemcitabine has been proven to prolong overall survival in the patient with advanced pancreatic cancer. In addition to common adverse effects, such as diarrhea, mucositis and skin rash (acne form eruptions), acute interstitial lung disease (ILD) has been reported as an infrequent but potentially fatal complication. We here report a case of a Japanese patient with erlotinib-induced ILD in whom high-dose corticosteroid therapy was successful. Case report A fifty five-year-old male with cancer of the head of the pancreas with multiple liver metastases started treatment with gemcitabine plus erlotinib. On the 13th day of erlotinib treatment, he had high fever. Chest computed tomography (CT) scan showed a diffuse ground-glass like infiltration of bothlungs. He was diagnosed with ILD, and high-dose corticosteroid therapy was started. Two weeks after the introduction of steroid therapy, the reticular shadow faded away on CT. He was successfully treated with corticosteroid for erlotinib-induced acute ILD although he died 6 months after the initiation of chemotherapy owing to disease progression. Conclusion we showed a case of a successfully treated Japanese patient of erlotinib-induced ILD. Because erlotinib-induced ILD would frequently occur in Japanese patients, closer attention to ILD should be paid for Japanese patients than in Western populations. If erlotinib-induced ILD occurs, a high-dose corticosteroid therapy would be a useful option of treatment.
Erlotinib; Gemcitabine; Lung Diseases, Interstitial; Pancreatic Neoplasms
Gemcitabine became a standard treatment for advanced pancreatic cancer since its superiority over fluorouracil was shown [1]. Since then, trials of many agents in combination with gemcitabine have failed to show survival improvement compared with gemcitabine alone [2, 3]. In contrast to these unsuccessful strategies, a regimen of erlotinib (Tarceva®, F. Hoffmann-La Roche AG, Basel, Switzerland) plus gemcitabine has been proven to prolong overall survival [4].
Erlotinib is a selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used as a target therapy against non-small lung cancer (NSCLC) and advanced pancreatic cancer [5, 6]. Erlotinib is well tolerated and carries fewer adverse effects than most cytotoxic drugs. Among these EGFR-TKI agents, including gefitinib and erlotinib, common dose-limiting toxicities are diarrhea, mucositis and skin rash (acne form eruptions).
In addition to these common adverse effects, acute interstitial lung disease (ILD) has been reported as an infrequent but potentially fatal complication [7]. Gefitinib- associated ILD reportedly occurs in approximately 1% of patients worldwide [8], but only a few case reports have been published with erlotinib [7, 9].
We here report a case of a Japanese patient with erlotinib- induced ILD in whom high-dose corticosteroid therapy was successful.
A fifty five-year-old male had been admitted to our hospital for pancreatic cancer. He was not a smoker and had no history of pulmonary disease. An abdominal computed tomography (CT) scan revealed a tumor measuring 30 mm in diameter at the head of the pancreas (Figure 1a) with multiple liver metastases (Figure 1b, 1c). He was treated with gemcitabine in combination with erlotinib. Gemcitabine was administered with a protocol of 1,000 mg/m2 weekly for 3 weeks followed by 1 week rest. Erlotinib was administered with a protocol of 100 mg/body every day. One week after starting erlotinib, he developed a skin rash-mainly affecting the face and neck-which was controlled by oral minocycline without worsening. On the 13th day of erlotinib treatment, he presented with a fever elevated up to 40 degrees. No clinical focus of infection was found. Vital signs were stable, white blood cell (WBC) count was within normal limits 6,400 μL-1; reference range: 0-9,000 μL-1, and C-reactive protein (CRP) was slightly elevated (1.98 mg/dl; reference range <0.1 mg/dl). On the next day, the high fever continued and WBC count elevated to 11,800 μL-1. CRP level was also elevated to 16.09 mg/ dl. The percentage of blood eosinophil was within normal limits (1%; reference range 2–6%). Serum KL-6 level was within normal limits (448 U/ml; reference range <499 U/ ml). Chest X-ray revealed reticular shadow in the bilateral lung fields. Chest CT scan showed a diffuse ground-glass like infiltration of both lungs without any sign of pulmonary edema or pleural effusions (Figure 2a, 2b). He was diagnosed with ILD, and a high-dose corticosteroid with an antibiotic agent therapy was introduced. Prednisolone was applied with an initial dose of 1,000 mg/day for 3 days and an antibiotic agent was also applied for 3 days. After that, the reticular shadow was reduced gradually on CT. Following a high-dose corticosteroid pulse therapy, prednisolone was applied for internal use with a dose of 60mg/day. Two weeks after the introduction of steroid therapy, the ILD faded away on CT (Figure 2c, 2d). The dose of corticosteroid was gradually decreased by half every 2 weeks. Corticosteroid therapy was continued for 10 weeks. For detection of allergic response against erlotinib and gemcitabine, drug-induced lymphocyte stimulation test (DLST) was performed 4 weeks after occurrence of ILD. The stimulation indices were 84% of the control in gemcitabine and 88% in erlotinib, and therefore judged as negative.
Figure 1. (a) Computed tomography (CT) imaging of the abdomen on admission. There is a tumor in the head of the pancreas (arrow), (b, c) CT shows multiple liver metastases (arrows).
Figure 2. (a, b) Chest computed tomography (CT) shows the onset of interstitial lung disease (ILD) on both lung fields, (c, d) ILD are faded out on chest CT two weeks after the introduction of steroid therapy.
Thereafter, he received chemotherapy with S-1, an oral fluoropyrimidine, administered at 80 mg/m2/day for 2 weeks followed by a 1 week rest. Six weeks after starting S-1 therapy, the tumor of the pancreas head was enlarged to 37 mm in diameter, suggesting that S-1 was ineffective. Although we could not rule out a possibility of gemcitabine as the cause of ILD, we again tried gemcitabine complying with the patient's strong desire. Before the administration of gemcitabine, we repeatedly explained the risk of recurrence of ILD and took an informed consent. After re- starting gemcitabine, ILD did not occur again. Gemcitabine was continued for 6 weeks, but the tumor further enlarged to 51mm in diameter. Six months after the initiation of first chemotherapy, he died of disease progression.
Human epidermal growth factor receptor type 1 (HER1/ EGFR) is over-expressed in many pancreatic tumors [10, 11] and associated with poor prognosis and disease progression [12, 13]. Blocking HER1/EGFR TK signaling decreases the growth and metastasis of human pancreatic tumor xenografts [14] and enhances anticancer effects of gemcitabine [15]. In gastrointestinal oncology, erlotinib is currently applied in combination with gemcitabine as a first-line therapy for advanced-stage pancreatic cancers [6]. In advanced pancreatic cancers, such as recurrence post surgery or inoperable situations, gemcitabine and S-1 are commonly used for chemotherapy against metastasis and chemoradiotherapy against locally advanced tumors; however, newly developing molecular-targeting drugs like erlotinib are strongly anticipated for their effect against pancreatic cancers. Although the precise mechanism of toxicity remains to be elucidated, impaired metabolism of erlotinib is assumed to aggravate erlotinib toxicity [16]. In humans, erlotinib is metabolized by cytochrome P450 enzymes, predominantly by CYP3A4 and to a lesser part by CYP1A2 and CYP1A1 [17]. The reactive intermediates formed during erlotinib metabolism are cellular oxidases, which may produce oxidative stress by modifying cellular proteins. The oxidative stress potentially contributes to the clinically observed toxicities [16, 17].
The phase III trial by the National Cancer Institute of Canada Clinical Trials Group, which led to approval of erlotinib in combination with gemcitabine for advanced pancreatic cancers, reported an incidence of ILD-like toxicities as 2.1% in the patients treated with erlotinib plus gemcitabine versus 0.4% in the patients treated with placebo plus gemcitabine [4]. There is no randomized controlled trial to guide the management of EGFR-TKI agent-induced ILD. Previous policy of management for EGFR-TKI agent-induced ILD was to discontinue this medication and to start oxygen therapy. However, several researchers indicated that a high-dose steroid treatment was effective in ILD caused by gefitinib [18].
With regard to the successful treatment by corticosteroid therapy for erlotinib-induced acute ILD in pancreatic cancer patients, there are only 2 case reports in the English literature thus far (Table 1). Boeck et al. reported the first case of successful treatment of ILD in a patient with metastatic pancreatic cancer [19]. This patient had taken gemcitabine plus erlotinib (150 mg daily) treatment within the phase III trial. In this report, because a severe skin rash had occurred after 2 weeks of treatment, erlotinib was temporally discontinued for 1 week. Thereafter, treatment had re-started with a reduced dose of 100 mg/ daily for erlotinib. Seven weeks after the initiation of chemotherapy, acute ILD had occurred. He was treated with a high-dose steroid (prednisolone) therapy with an initial dose of 900 mg/day for 3 days. A CT scan 7 days after introducing steroid therapy showed a complete recovery from ILD. Kundel et al. reported the second case [20]. This patient was treated with 1,000 mg/m2 gemcitabine weekly and 100 mg of erlotinib daily for pancreatic cancer and hepatic metastases. After 6 months of therapy, acute ILD had occurred. Following the corticosteroid therapy, a complete resolution of acute ILD was confirmed on CT scan. Unfortunately, the dose of corticosteroid was not stated in this report.
Concerning the susceptibility to EGFR-TKI drug-associated ILD with respect to race, ILD occurred only in 2.4% of pancreatic cancer patients who were treated with gemcitabine plus erlotinib according to Moore et al. [4]. On the other hand, in the similar study in Japanese patients by Okusaka et al. [21], ILD-like events occurred in 9 patients from 107 patients (8.5%). This higher incidence in Japanese patients is authenticated by the post-marketing surveillance of erlotinib in Japan, in which the incidence of ILD-like events was computed as 6.1% in 313 patients [22]. These two reports implied that the incidence of erlotinib-associated ILD is much higher in the Japanese population than Western populations. Similar difference of susceptibility is observed in gefitinib. According to the U.S. Food and Drug Administration (FDA) drug approval summary, the incidence of gefitinib-associated ILD was 2% in Japanese patients and about 0.3% in the United States patients [8]. Moreover, in the study of Takano et al., the incidence of gefitinib-induced ILD in Japanese patients was as high as 5.4% [23]. Concerning the difference of incidence in Japanese patients between the FDA summary and Takano's study, Takano gave his opinion that many ILD cases might not have been reported because a follow-up survey of all cases had not been conducted. Nevertheless, gefitinib-induced ILD also occurs more frequently in the Japanese population than the Western population. Taken together, Japanese patients might have a higher risk for the incidence of ILD toward EGFR-TKI drugs.
The mechanism of EGFR-TKI-induced ILD is still not elucidated. EGFR has important roles in the maintenance and repair of epithelial tissues by regulating cell migration, differentiation, proliferation and survival. EGFR is expressed in type II pneumocytes, which are responsible for recovery of normal alveolar architecture following alveolar injury. Higenbottam et al. postulated that inhibition of EGFR would partly reduce the pneumocyte capacity responding to lung injury [24]. Because the ILD in our patient occurred rapidly on the 13th day of erlotinib treatment, drug hypersensitivity was a possible mechanism. Although we failed to examine Ig-E levels, acute hypersensitivity reaction was very improbable. This was the first time the patient had ever received erlotinib and his blood eosinophil count did not alter at all during the course, remaining in the normal range. In relation to delayed hypersensitivity as well, the DLST result was negative. Therefore we deem that the allergic mechanism was unlikely in our patient. At present, the exact reason why ILD was induced by erlotinib in this patient is not uncovered but causal relationship between the ILD and erlotinib is strongly inferred from his clinical course.
In conclusion, we showed a case of a successfully treated Japanese patient of erlotinib-induced ILD. Because erlotinib-induced ILD would frequently occur in Japanese patients, closer attention to ILD should be paid for Japanese patients than in Western populations. If erlotinib-induced ILD occurs, a high-dose corticosteroid therapy would be a useful option of treatment.
Conflicting Interest
Authors declare to have no conflict of interest.
Burris HA 3rd, Moore MJ, Andersen J, et al. Improvement in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J ClinOncol. 1997; 15: 2403-2413. [PMID: 9196156]
Berlin JD, Catalano P, Thomas JP, et al. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J ClinOncol. 2002; 20: 3270-3275. [PMID: 12149301]
Rocha Lima CM, Green MR, Rotche R, et al. Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J ClinOncol. 2004; 22: 3776-3783. [PMID: 15365074]
Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advancer pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J ClinOncol. 2007; 25: 1960-1966. [PMID: 17452677]
Ray M, Salgia R, Vokes EE. The role of EGFR inhibition in the treatment of non-small cell lung cancer. Oncologist. 2009; 14: 1116-1130. [PMID: 19892771]
Senderowicz AM, Johnson JR, Sridhara R, et al. Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas. Oncology. 2007; 21: 1696-1706. [PMID: 18247017]
Liu V, White DA, Zakowski MF, et al. Pulumonary toxicity associated with erlotinib. Chest. 2007; 132: 1042-1044. [PMID: 17873198]
Cohen MH, Williams GA, Sridhara R, et al. FDA drug approval summary: gefitinib (ZD1839) (Iressa) tablets. Oncologist. 2003; 8: 303- 306. [PMID: 12897327]
Lai YC, Lin PC, Lai JI, et al. Successful treatment of erlotinib-induced acute hepatitis and acute interstitial pneuronitis with high-dose corticosteroid: a case report and literature review. Int J ClinPharmacolTher. 2011; 49: 461-466. [PMID: 21726497]
Fjällskog ML, Lejonklou MH, Oberg KE, et al. Expression of molecular targets for tyrosine kinase receptor antagonists in malignant endocrine pancreatic tumors. Clin Cancer Res. 2003; 9: 1469-1473. [PMID: 12684421]
Tobita K, Kijima H, Dowaki S, et al. Epidermal growth factor receptor expression in human pancreatic cancer: Significance for liver metastasis. Int J Mol Med. 2003; 11: 305-309. [PMID: 12579331]
Xiong HQ. Molecular targeting therapy for pancreatic cancer. Cancer ChemotherPharmacol. 2004; 54: S69-77. [PMID: 15316751]
Ueda S, Ogata S, Tsuda H, et al. The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas. 2004; 29: e1-e8. [PMID: 15211117]
Bruns CJ, Solorzano CC, Harbison MT, et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 2000; 60: 2926-2935. [PMID: 10850439]
Ng SS, Tsao MS, Nicklee T, Hedley DW. Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Mol Cancer Ther. 2002; 1: 777-783. [PMID: 12492110]
Li X, Kamenecka TM, Cameron MD. Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile. Drug MetabDispos. 2010; 38: 1238-1245. [PMID: 20382753]
Van Erp NP, Gelderblom H, Guchelaar HJ. Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009; 35: 692-706. [PMID: 19733976]
Kuo LC, Lin PC, Wang KF, et al. Successful treatment of gefitinib-induced acute interstitial pneumonitis with high-dose corticosteroid: a case report and literature review. Med Oncol. 2011; 28: 79-82. [PMID: 20087691]
Boeck S, Hausmann A, Reibke R, et al. Severe lung and skin toxicity during treatment with gemcitabine and erlotinib for metastatic pancreatic cancer. Anticancer Drugs. 2007; 18: 1109-1111. [PMID: 17704662]
Kunkel J, Loddenkemper C, Grozdanovic Z, et al. Interstitial lung disease under erlotinib plus gemcitabine for pancreatic carcinoma: a therapeutic dilemma. Pancreas. 2011; 40: 170-171. [PMID: 21160383]
Okusaka T, Furuse J, Funakoshi A, et al. Phase II study of erlotinib plus gemcitabine in Japanese patients with unresectable pancreatic cancer. Cancer Sci. 2011; 102: 425-431. [PMID: 21175992]
Chugai-pharm. Co. ltd.: Midterm report of all-patient investigation of pancreas cancer with erlotinib (brand name: Tarceva) in Japan. 2012 (in Japanese).
Takano T, Ohe Y, Kusumoto M, et al. Risk factors for interstitial lung disease and predictive factors for tumor response in patients with advanced non-small cell lung cancer treated with gefitinib. Lung Cancer. 2004; 45: 93-104. [PMID: 15196739]
Higenbottam T, Kuwano K, Nemery B, Fujita Y. Understanding the mechanisms of drug-associated interstitial lung disease. Br J Cancer. 2004; 91: S31-37. [PMID: 15340376]

redpajama_set_name: RedPajamaCommonCrawl


Old St. Mary's wishes everyone a very Happy New Year! May God's Blessings descend upon all the parishioners, supporters, and truly all people this upcoming new year.
Remember that New Year's is a Holy Day of Obligation. Masses will be December 31 at 10 pm and January 1 at 11 am. Be sure to get to Mass.


text:
Q: Is it grammatical to use "[verb]-ing an [object] by an [subject]"?
The story is about the stoning an innocent young woman for adultery by a group of radical religious hypocrites.

In the above sentence "radical religious hypocrites" is the subject who did the stoning. Is it correct grammatically use verb-ing followed by the subject? Or should it be "radical religious hypocrites' stoning of an innocent young woman"? Normally I would think that the noun following "-ing form by" is the instrument used to do the task (verb), rather than subject, e.g. "Opening the door by a key", "Sending a message by the phone" , and so on . Other examples I am skeptic of whose correctness include "reaching international ranks by hardworking athletes", "Opening new national developmental horizons by aerospace scientists", "importing a new class of SUVs by the government", "Watching porn by a frustrated guy", and so on.

A:
stoning of an innocent young woman for adultery by a group of radical religious hypocrites.

it is a gerund phrase as object of the preposition "about".
http://grammar.ccc.commnet.edu/grammar/phrases.htm

redpajama_set_name: RedPajamaStackExchange


text:
CNNI Simulcast
ALJAZAM (Al Jazeera)
Congressional Gold Medal Ceremony : CSPAN3 : February 22, 2015 9:00pm-10:02pm EST
operations team was formed in 1942 and helped liberate much of europe. both american and canadian veterans attended the event at the u.s. capitol. this program lasts about an hour. [applause] >> ladies and gentlemen, the speaker of the united states house of representatives, the honorable john boehner. [applause] >> ladies and gentlemen, good afternoon and welcome to the united states capitol. it's good to see all of you here today. since the days of the revolution, congress has awarded gold medals to express the people's appreciation for distinguished achievements. the first recipient was general george washington himself in march of 1776. today pursuant to house resolution 324 we will present a gold medal in honor of the first special service force. the force was activated in 1942 as an elite unit of 1800 american and canadian commandos. just how elite? well, for every man they lost, they killed 25. for every man they captured, they took 235. the force was so fierceless that the enemy dubbed them the devils and so effective today that our special forces refer to them as pioneers
operations team was formed in 1942 and helped liberate much of europe. both american and canadian veterans attended the event at the u.s. capitol. this program lasts about an hour. [applause] >> ladies and gentlemen, the speaker of the united states house of representatives, the honorable john boehner. [applause] >> ladies and gentlemen, good afternoon and welcome to the united states capitol. it's good to see all of you here today. since the days of the revolution, congress has...
Key Capitol Hill Hearings : CSPAN2 : February 3, 2015 10:00pm-12:01am EST
american and canadian commanders. just how elite? well, well, for every man they lost they killed 25. for every man they captured they took 235. the force was so fearless the enemy dubbed them the "devil's brigade" and so effective today our special forces refer to them as pioneers. these men represent the finest of the finest. today we bestow them -- the stowe on them our highest honor. let me thank all of you for being here. of course we are humbled to have with us some 42 veterans of the force please join me now in welcoming these great men to our hall. [applause] [applause] >> ladies and gentlemen please stand for the presentation of the colors the singing of the canadian and united states national anthem, and the retiring of the colors. ♪ ♪ ♪ ♪♪ ♪ ♪ ♪♪ ♪ ♪♪ ♪ ♪♪ ♪ ♪ ♪♪ ♪ ♪ ♪ ♪ ♪ ♪ ♪ ♪ ♪ ♪ ♪ ♪♪ ♪ [applause] ♪ ♪ ♪♪ ♪ ♪ >> ladies and gentlemen please remain standing as the chaplain of the united states senate gives the implication. >> let us pray. eternal god the heavens tell stories of your glory and the
american and canadian commanders. just how elite? well, well, for every man they lost they killed 25. for every man they captured they took 235. the force was so fearless the enemy dubbed them the "devil's brigade" and so effective today our special forces refer to them as pioneers. these men represent the finest of the finest. today we bestow them -- the stowe on them our highest honor. let me thank all of you for being here. of course we are humbled to have with us some 42 veterans...
Fault Lines : ALJAZAM : February 12, 2015 7:00am-7:31am EST
by ALJAZAM
canadian egyptian journalist who was our bureau chief in cairo at the time of his arrest in december, 2013. prior joining al jazeera he worked for the new york times c.n.n. and national committee of the red cross. the 40-year-old holds degrees from montreal's lasalle college and vancouver city university. he's an accomplished author. he's written a book about his time working as an interpreter and journalist in iraq and co written a book on the 2011 egyptian revolution. during his imprisonment in cairo, he got engaged to his girlfriend, and they hope to marry soon. >> mohamed fahmy's brother has been speaking to journalists after the court broke up. >> following everything, egyptian law and i'm sure he's bin vicinity indicated liable and complete vindicated when this case false apart completely. everything was possible. we wanted to keep ourselves not too excited and just expect, wanted to expect the worst but we got something so... >> already let's get reaction then from sean mccarthy, president of the canadian committee for word press freedom. he's on the line now from ottawa. can i get
canadian egyptian journalist who was our bureau chief in cairo at the time of his arrest in december, 2013. prior joining al jazeera he worked for the new york times c.n.n. and national committee of the red cross. the 40-year-old holds degrees from montreal's lasalle college and vancouver city university. he's an accomplished author. he's written a book about his time working as an interpreter and journalist in iraq and co written a book on the 2011 egyptian revolution. during his imprisonment...
Politics & Public Policy Today : CSPAN3 : February 3, 2015 2:00pm-4:01pm EST
special service force during world war ii. it was an american/canadian special operations unit formed in 1942. we expect to hear remarks from congressional leaders and two veterans. this is just getting under way. >> the honorable john boehner. >> ladies and gentlemen, good afternoon and welcome to the united states capitol. it's good to see all of you here today. since the days of the revolution, congress has awarded gold medals to express the people's appreciation for distinguished achievements. the first recipient was general george washington himself in march of 1776. today pursuant to house resolution 324 we will present a gold medal in honor of the first special service force. the force was activated in 1942 as an elite unit of 1800 american and canadian commandos. just how elite? well, for every man they lost they killed 25. for every man they captured, they took 235. the force was so fierceless that the enemy dubbed them the devils and so effective today that our special forces refer to them as pioneers. these men represent the finest of the finest. so, today we bestow them -- on
special service force during world war ii. it was an american/canadian special operations unit formed in 1942. we expect to hear remarks from congressional leaders and two veterans. this is just getting under way. >> the honorable john boehner. >> ladies and gentlemen, good afternoon and welcome to the united states capitol. it's good to see all of you here today. since the days of the revolution, congress has awarded gold medals to express the people's appreciation for...
Key Capitol Hill Hearings : CSPAN2 : February 5, 2015 6:00pm-8:01pm EST
service. service. an american canadian special operations unit formed in 19 82. we will here from readers about the house and senate and members of the special service force. >> since the days of the revolution congress has awarded gold medals to express the people's appreciation for distinguished achievements. the 1st recipient was gen. george washington himself in march 1776. today pursuant to house resolution 324 we will resolution 324 we will present a gold medal in honor of the 1st special service force. the force was activated in 1942 as an elite unit of 1800 american and canadian commanders. just how elite? well, well, for every man that they lost they killed 25. for for every man they captured they took 235. the force was so. was that the enemy dump them the devils, and devils, and so effective today that our special forces refer to them as pioneers. these men represent the finest of the finest. so today we bestow them -- bestow on them our highest honor. let me thank all of you for being here especially the ambassador, secretary, and all of our army leaders. of course, in
service. service. an american canadian special operations unit formed in 19 82. we will here from readers about the house and senate and members of the special service force. >> since the days of the revolution congress has awarded gold medals to express the people's appreciation for distinguished achievements. the 1st recipient was gen. george washington himself in march 1776. today pursuant to house resolution 324 we will resolution 324 we will present a gold medal in honor of the 1st...
Anderson Cooper 360 : CNNW : February 26, 2015 5:00pm-6:01pm PST
young recruit recruit. four canadians maybe more potentially in syria potentially part of the fight already and we learned today from the director of counterterrorism center more than 40 westerners have gone off to fight for isis so far. that total including 180 americans according to the director of national intelligence and possibly those young canadians. our paula is there. >> reporter: we know sometimes they were radicalized the families alerted local authorities first they were missing. i it became apparent in a few days they went to national security officials and went to the middle east likely trying to get to syria in the hopes of joining isis. and the fact remains, anderson that these families are frantic right now trying to figure out what actually happened to their children. >> so their exact location right now is not known. >> reporter: no and in fact security officials on the ground in turkey are trying to help canadian officials but as we just discussed, anderson there are many westerners right now that security authorities are trying to track, and it's a huge problem.
young recruit recruit. four canadians maybe more potentially in syria potentially part of the fight already and we learned today from the director of counterterrorism center more than 40 westerners have gone off to fight for isis so far. that total including 180 americans according to the director of national intelligence and possibly those young canadians. our paula is there. >> reporter: we know sometimes they were radicalized the families alerted local authorities first they were...
News : ALJAZAM : February 6, 2015 11:00pm-11:31pm EST
supreme court of canada granting canadians the rights she was denied. >> the nine justices have given federal and provincial governments a year to craft laws. after that the law will stand. >> this is a momentous day a historic day a day i think that we as canadians can celebrate. >> reporter: but others opposed the ruling including so-called dying with dignity bills that have passed in parliament. one doctor telling al jazeera last year it's her job to save lives not take them. >> they want to redefine our profession and want to institutionalize in quebec killing patients and calling it health care. >> highly charged debates four states vermont montana washington and oregon, allow some form of doctor assisted suicide. >> i will die upstairs in my bedroom that i share with my husband. with my mother and my husband by my side. >> last year, brittany maynard changed the face of there right to die in the u.s. maynard suffering from frequent seizures and stroke like symptoms died, weeks after she told the world she would take her life. >> if all my dreams came true i would somehow describ
supreme court of canada granting canadians the rights she was denied. >> the nine justices have given federal and provincial governments a year to craft laws. after that the law will stand. >> this is a momentous day a historic day a day i think that we as canadians can celebrate. >> reporter: but others opposed the ruling including so-called dying with dignity bills that have passed in parliament. one doctor telling al jazeera last year it's her job to save lives not take...
waiting to erupt across this oil, gas and fresh-water rich country. back in 2010, the canadian province of new brunswick granted a texas-based company, southwestern energy, licenses to explore for shale gas - in exchange for investment worth 47 million dollars. if shale gas extraction goes ahead, it will be a boon to new brunswick's struggling economy. the province anticipates it could generate over a thousand jobs and 1.5 billion dollars staunching the exodus of workers west to alberta's oil sands. >> to have that kind of revenue inflow and that kind of potential, it would have a dramatic impact on the province. in fact, on the studies we looked at just a few weeks ago indicates that shale gas development could actually double the economic growth rates in the province. >> three years later these were the images from new brunswick flashing across canadian television screens. royal canadian mounted police guns trained on first nations people, police cars sent up in flames. >> we seized a number of firearms from the encampments at the protest site. we also found explosive devices
waiting to erupt across this oil, gas and fresh-water rich country. back in 2010, the canadian province of new brunswick granted a texas-based company, southwestern energy, licenses to explore for shale gas - in exchange for investment worth 47 million dollars. if shale gas extraction goes ahead, it will be a boon to new brunswick's struggling economy. the province anticipates it could generate over a thousand jobs and 1.5 billion dollars staunching the exodus of workers west to alberta's oil...
CNNI Simulcast : CNNW : February 27, 2015 12:00am-1:01am PST
programming. >> several students at the school flew to the middle east to join isis. >> canadian officials say they are at least for two women and two men maybe more. they have opened this investigation because the families came to them saying the children were missing. now, canadian officials. they are in turkey. they are clear that that was likely their intend and you know security officials in canada saying that they believe that this problem will continue to grow they want them to really keep an eye on what their children are doing and if they are susceptible to being radicalized. officials say that in this case that didn't happen. >> so many young people are buying into the social media recruiting of this brutal brutal group. we will look at what makes isis so effective at persuading the young to sign up. >> it is a strange and curious situation. alking about that good morning to you. and tell us more about what they knew about him. >> good morning, natalie. good morning john. that is the question that many people have been asking. i'm going to show you if times of london. a
programming. >> several students at the school flew to the middle east to join isis. >> canadian officials say they are at least for two women and two men maybe more. they have opened this investigation because the families came to them saying the children were missing. now, canadian officials. they are in turkey. they are clear that that was likely their intend and you know security officials in canada saying that they believe that this problem will continue to grow they want them...
canadians who could be in syria and potentially part of the fight already. and we are learning that nearly 3400 westerners have gone off to fight for isis already. and now according to the director of the nashltional intelligence include those four canadians. paula newton is in ottawa helping to cover the story. what do we know about the teens? >> we know they were radicalize ed in the last four month, and the families were alerted that they were missing, and it is apparent that it was hand eded off to the national security officials, and that they had gone overseas to the middle east likely trying to get to syria in the hopes of joining isis. the fact remains, anderson, that the families are frantic to find out what happened to the children. >> their exact leication is not known? >> no, the officials on the ground in turkey are trying to help the families figure out what happened. but the fact is that there are many westerners that authorityies trying to track, and it is a huge problem, and the trail is cold. once they step over into syria, it is very difficult to find out what happened t
canadians who could be in syria and potentially part of the fight already. and we are learning that nearly 3400 westerners have gone off to fight for isis already. and now according to the director of the nashltional intelligence include those four canadians. paula newton is in ottawa helping to cover the story. what do we know about the teens? >> we know they were radicalize ed in the last four month, and the families were alerted that they were missing, and it is apparent that it was...
On the Record With Greta Van Susteren : FOXNEWSW : February 27, 2015 4:00pm-5:01pm PST
least four canadian teenagers on their way to join isis. chief intelligence correspondent catherine herridge joins us. born in canada. >> canadian authorities believe they left the province of quebec and traveled to turkey and presume that they are now in syria. three of the teenagers went to a community college in montreal quebec, where they recently shut down this islamic group or institute on the basis of hate speech. so you you start to see this pattern. they leave canada. they get to turkey, and then they effective lose track of them as they go into syrian territory. >> what is this islamic group in this university? do you know anything about them? >> just a little bit. they -- their front or their cover is that they are providing koranic teachings. clearly a pattern of incidence that caused the school it to terminate their lease. >> now on february 27th. left sometime in january. >> that's correct. >> have u.s. intelligence authorities monitoring them. canadian intelligence monitoring them or now just come under everyone's radar screen today? >> what's clear from our report so
least four canadian teenagers on their way to join isis. chief intelligence correspondent catherine herridge joins us. born in canada. >> canadian authorities believe they left the province of quebec and traveled to turkey and presume that they are now in syria. three of the teenagers went to a community college in montreal quebec, where they recently shut down this islamic group or institute on the basis of hate speech. so you you start to see this pattern. they leave canada. they get...
ABC World News Tonight : KGO : February 14, 2015 5:30pm-6:01pm PST
murderous misfits. abc's kendis gibson has more. >> reporter: tonight, we're learning this canadian mall was the target of a planned valentine's day blood bath. police identifying a 23-year-old american woman, coconspirator, now in custody. law enforcement in canada say lindsay souvannarath a resident of a wealthy chicago suburb plotted with two canadian men to kill as many people as possible. >> based on what we know so far, it would have been devastating. mass casualties were a real possibility. >> reporter: police in the canadian province moving quickly after a crimestoppers call tipped them off to the plot. with just hours to spare, authorities locked down the tiny halifax town of timberley. early friday morning, officers enter a home and find a 19-year-old dead of a self-inflicted gunshot wound. law enforcement recovering three long-barrel rifles. moments later, 2:00 a.m., police make two arrests at the halifax airport. that american woman just entering the country, and a 20-year-old suspect, identified today as a canadian resident, randall shepherd. >> this appeared to be a gr
murderous misfits. abc's kendis gibson has more. >> reporter: tonight, we're learning this canadian mall was the target of a planned valentine's day blood bath. police identifying a 23-year-old american woman, coconspirator, now in custody. law enforcement in canada say lindsay souvannarath a resident of a wealthy chicago suburb plotted with two canadian men to kill as many people as possible. >> based on what we know so far, it would have been devastating. mass casualties were a...
News : ALJAZAM : February 9, 2015 9:00am-9:31am EST
say the prosecutors have not yet met their side of the agreement. the canadian government has expressed disappointment over egypt's decision to keep mohamed fahmy behind bars. canada released a statement that they are deeply upset. canada calls for the immediate release of mr. fahmy. >> a member of the canadian senate said canada's prime minister needs to push harder for mohamed fahmy's freedom. >> i sit here outraged over what happened in cairo with mohamed fahmy. i've always thought from the get-go that the prime minister of this country should have intervened right away. we've been told over the last many months that there are back channels, front channels and so on and so forth but it should be the main channel and the main channel is the prime minister of this country. any other canadian journalist who would be caught in a peculiar circumstance such as this would have been released a long time ago. it is up to prime minister harp tore pick up a phone and to talk to president al sisi and to get action done. mohamed fahmy is an egyptian, but as he canadians the australian j
say the prosecutors have not yet met their side of the agreement. the canadian government has expressed disappointment over egypt's decision to keep mohamed fahmy behind bars. canada released a statement that they are deeply upset. canada calls for the immediate release of mr. fahmy. >> a member of the canadian senate said canada's prime minister needs to push harder for mohamed fahmy's freedom. >> i sit here outraged over what happened in cairo with mohamed fahmy. i've always...
Titans at the Table : BLOOMBERG : February 8, 2015 8:00am-8:31am EST
controversial canadian oil sands. >> the question here was, is this a chance to change our trajectory in terms of energy? is this a chance to change the way people think about it and the way the policies are shaped around energy? >> we caught up with steyer in the tiny town of mayflower, arkansas, where he was getting a look at the cleanup site from an estimated 5000 barrel oil spill. [splashing] >> here is some just off the top of the water. it's sticky. it's extremely sticky. >> very sticky. >> it smells awful. >> in march 2013, a shallow underground pipeline owned by exxonmobil burst, sending oil running down a mayflower residential street, as can be seen in this video. >> the smell is unbelievable. i mean, look. there's oil. >> the oil flowed down the street through a drainage ditch and emptied into a marshy area. the heavy crude had come from alberta, canada, thousands of miles away. >> what are the booms for? >> they are to soak in the oil. they are supposed to -- >> literally? >> yeah. literally -- >> that's what they're for? >> yes. they're supposed to repel water and soak in oil
controversial canadian oil sands. >> the question here was, is this a chance to change our trajectory in terms of energy? is this a chance to change the way people think about it and the way the policies are shaped around energy? >> we caught up with steyer in the tiny town of mayflower, arkansas, where he was getting a look at the cleanup site from an estimated 5000 barrel oil spill. [splashing] >> here is some just off the top of the water. it's sticky. it's extremely...
House Debate on Keystone XL Oil Pipeline : CSPAN : February 14, 2015 2:10pm-3:21pm EST
the playing field between u.s. producers shipping oil and canadian companies shipping oil, which is going to be exported from the united states perhaps after it's refined. and so, again, this will be a shift on the republican side of the aisle because you will be voting for language that says congress should approve a bill to ensure that all forms of oil are subject to the per barrel excise tax associated with the oil spill liability trust fund. which would be i think the first time the republican side has endorsed any sort -- well, no, there was the tax increase for inland waterway users buried in that bill in deals. but this will be the second time ics he have voted to increase a tax and i'm really thrilled to see that and the fact that we will be writing that in equity and the republicans will be endorsing something we've offered numerous times on the floor. the third thing which really isn't an improvement, is some senators stuck in language saying that when this foreign corporation takes american citizens' private property against their will they have to follow the constitution
the playing field between u.s. producers shipping oil and canadian companies shipping oil, which is going to be exported from the united states perhaps after it's refined. and so, again, this will be a shift on the republican side of the aisle because you will be voting for language that says congress should approve a bill to ensure that all forms of oil are subject to the per barrel excise tax associated with the oil spill liability trust fund. which would be i think the first time the...
Fox 29 News at 6PM : WTXF : February 15, 2015 6:00pm-7:01pm EST
the canadian maritime. in its wake bitter cold and wind all across the northeast. we have wind chill advisory out until 11:00 a.m. for the the whole delaware valley. air temperatures will challenge record lows but with the wind still gusting to 20 miles an hour by tomorrow morning it will feel like 15 to 20 below. you go to the higher elevations, we will go to where it is even colder namely in the pocono mountains carbon and monroe counties and lancaster county extending into central pennsylvania, that is a whipped chill warning that can feel as cold as 35 degrees below zero. it is presidents day tomorrow. good thing most kid are off from school and don't have to go to the bus stop but prepare for a brutally cold morning. temperatures right now only 15 in philadelphia. eleven in pottstown. two below is the air temperature at the top of mount pocono. the in the wind which have come down slight thely from earlier this morning we saw gusts to 54 miles an hour at the airport overnight. they are now still around 20 to 25 miles an hour sustain north and west of the city some higher gusts s
the canadian maritime. in its wake bitter cold and wind all across the northeast. we have wind chill advisory out until 11:00 a.m. for the the whole delaware valley. air temperatures will challenge record lows but with the wind still gusting to 20 miles an hour by tomorrow morning it will feel like 15 to 20 below. you go to the higher elevations, we will go to where it is even colder namely in the pocono mountains carbon and monroe counties and lancaster county extending into central...
CNNI Simulcast : CNNW : February 14, 2015 2:00am-3:01am PST
. >>> canadian authorities track a woman with foufl tie to isis traveling to iraq and syria. up next what clues she may have left mind for investigators back in toronto. >>> and the latest on the investigation into the arguech teen president and her potential coverup of a bombing. that's coming up later. not only safely whitens teeth, but also restores enamel. lose the nerves and get a healthier whiter smile that you'll love. listerine® healthy white™. power to your mouth™! everyone loves the way dark clothes make them feel... and no one wants that feeling to fade. that's why there's woolite darks. without harsh ingredients, it keeps darks vibrant for over 30 washes. so your love for dark clothes doesn't have to fade. for the love of darks. woolite darks. let me get this straight... [ female voice ] yes? lactaid® is 100% real milk? right. real milk. but it won't cause me discomfort. exactly because it's milk without the lactose. and it tastes? it's real milk! come on, would i lie about this? [ female announcer ] lactaid. 100% real milk. no discomfort. >>> welcome back to our viewers
. >>> canadian authorities track a woman with foufl tie to isis traveling to iraq and syria. up next what clues she may have left mind for investigators back in toronto. >>> and the latest on the investigation into the arguech teen president and her potential coverup of a bombing. that's coming up later. not only safely whitens teeth, but also restores enamel. lose the nerves and get a healthier whiter smile that you'll love. listerine® healthy white™. power to your...
America Tonight : ALJAZAM : February 19, 2015 10:00pm-10:31pm EST
threat. thousands of americans, canadians too, have left home to join violent groups overseas. i.s.i.l. and al qaeda among them. it's a growing concern for our communities, and for the families of these lost boys a real heartbreak as sheila macvicar found in calgary. so they come into your house and hask you questions. -- arriving you questions. >> i said "i don't know why you are asking questions, damien is not in the country, he's in egypt to study, these not here he's not a concern." that's when they said "yes he's a concern. we have been watching him for a couple of years. we suspect he's gone to syria, not egypt." . >> reporter: when she figured out what was going on gaudreau attempted to reach out to her son. it was too late. >> he said he couldn't come home. he finally found a purpose in life. he found where he belonged. he wasn't coming home. that was going to be his new home, and he hope pd he could stay in -- hoped he could stay and he wouldn't be in contact. >> reporter: gaudreau never heard from damien again, he is was killed. >>> fast-forward canadian lawmakers are taking
threat. thousands of americans, canadians too, have left home to join violent groups overseas. i.s.i.l. and al qaeda among them. it's a growing concern for our communities, and for the families of these lost boys a real heartbreak as sheila macvicar found in calgary. so they come into your house and hask you questions. -- arriving you questions. >> i said "i don't know why you are asking questions, damien is not in the country, he's in egypt to study, these not here he's not a...
The Daily Show With Jon Stewart : COM : February 18, 2015 6:24pm-6:57pm PST
by COM
been stalled for six years at the canadian border awaiting the president's approval. >> jon: oh! poor lonely pipeline! i don't know why the oil doesn't just go around america this way and just sneak in from the mexican side. apparently, we don't even patrol that area! (laughter) but obviously the keystone pipeline is an incredibly contentious issue. i imagine the new congress is gonna want to put an issue like this on ice for a bit and start small with some other less divisive legislation. >> first item up in the new senate will be the keystone xl pipeline. >> i can confirm for you that if this bill passes this congress the president wouldn't sign it. >> jon: gonna be a fun two years! (laughter) well, first thing we're gonna do is poke you in the chest! well, i can assure you the president will break your (bleep) fingers. (laughter) so here we go. we have an impasse. keystone pipeline, it's been lasting over half a decade! i've gotta tell you, for something to get this contentious, to last this long, it has got to be some special pipeline. i assume the first of its kind. >> canada alr
been stalled for six years at the canadian border awaiting the president's approval. >> jon: oh! poor lonely pipeline! i don't know why the oil doesn't just go around america this way and just sneak in from the mexican side. apparently, we don't even patrol that area! (laughter) but obviously the keystone pipeline is an incredibly contentious issue. i imagine the new congress is gonna want to put an issue like this on ice for a bit and start small with some other less divisive...
News : ALJAZAM : February 10, 2015 9:00am-9:31am EST
jazeera. >> the canadian government is calling for the immediate release of mohamed fahmy the al jazeera journalist and canadian citizen has been in jail in egypt for 409 days, along with his producer, bar mohammad. the junior foreign minister tweeted prime minister harper has personally raised the case of mohamed fahmy with the highest level of the egyptian leadership. canadian officials raised the case of mohamed fahmy with egyptian officials 15 times in the last nine days. we understand this is an upsetting time for the family, we continue to call for mohamed fahmy's immediate release. the two are accused of supporting the outlawed muslim brotherhood, charges they and al jazeera deny. their earlier conviction had been thrown out. two face retrial on thursday. a third al jazeera journalist, peter greste has been unconditionally released. >> india's common man party has swept the delhi state elections. the anti corruption party won 67 out of 70 seats. the ruling b.j.p. which won the national elections last year took the remaining three. we have more now on what the new party is
jazeera. >> the canadian government is calling for the immediate release of mohamed fahmy the al jazeera journalist and canadian citizen has been in jail in egypt for 409 days, along with his producer, bar mohammad. the junior foreign minister tweeted prime minister harper has personally raised the case of mohamed fahmy with the highest level of the egyptian leadership. canadian officials raised the case of mohamed fahmy with egyptian officials 15 times in the last nine days. we...
News : ALJAZAM : February 8, 2015 12:00am-12:31am EST
long-time curfew hours before a series of deadly bombings >>> canadians fight a downhill battle for the right to go tobogganing. >>> the u.s. says it is deeply disappointed at nigeria's decision to postpone elections due to violence in the north-east of the country. the presidential election and the government races held on the 14th and 28th february will now happen six weeks later. we have more after the announcement was made. >> the head of nigeria's election commission said he was ready and able to conduct the polls. security chiefs said they could not guarantee the safety of voters, in particular in areas affected by boko haram. >> if the security of personnel, voters election observers, and election materials cannot be guaranteed the life of didn't young men and women, as prospects for free fair, credible and peaceful elections will be affected. consequently the commission decided to delay the elections. the national elections - presidential and national assembly are now to hold on march 28th, 2015. >> reporter: people have been protesting a delay in voting. outside the elector
long-time curfew hours before a series of deadly bombings >>> canadians fight a downhill battle for the right to go tobogganing. >>> the u.s. says it is deeply disappointed at nigeria's decision to postpone elections due to violence in the north-east of the country. the presidential election and the government races held on the 14th and 28th february will now happen six weeks later. we have more after the announcement was made. >> the head of nigeria's election...
Titans at the Table : BLOOMBERG : February 14, 2015 1:00pm-1:31pm EST
at the xl keystone pipeline proposal. >> he believes building the pipeline will escalate canadian oil. >> the question here was, is this a chance to change our trajectory? in terms of energy. is this a chance to change the way people think about it in the way the policy is shaped around energy? >> we caught up with him in arkansas where he was getting a look at the cleanup of an oil spill. here is some just off the top of the water. it's sticky. it's extremely sticky. >> very sticky. >> it smells awful. >> in march, 2013, a shallow underground pipeline owned by exxon mobil burst, sending oil down a residential street, as you see in this video. >> the smell is unbelievable. look, there is oil. >> the oil flowed down the street through a drainage ditch. it m.d. into a marshy area -- it emptied into a marshy area. the crews had come from alberta, canada, thousands of miles away. for.at are the booms >> they are to soak in the oil. they are supposed to. >> literally? >> literally. they are supposed to soak in water. >> steyer had come to mayflower together ammunition for what may be t
at the xl keystone pipeline proposal. >> he believes building the pipeline will escalate canadian oil. >> the question here was, is this a chance to change our trajectory? in terms of energy. is this a chance to change the way people think about it in the way the policy is shaped around energy? >> we caught up with him in arkansas where he was getting a look at the cleanup of an oil spill. here is some just off the top of the water. it's sticky. it's extremely sticky....
KPIX 5 News at 5pm : KPIX : February 18, 2015 5:00pm-5:31pm PST
dominant one. and then one off the canadian coastline. the one to our north is taking over. it's does we'll have less onshore flow and more of a north wind. you would think cold with the north wind but this time of year sometimes a north wind just dries us out, less cloud cover, more sunshine making us warmer back in the 70s on friday and saturday. then we get a surge of canadian air. we have been talking about a storm system that will miss us to the east but the counterclockwise flow around it will drag down cool canadian air from the 70s to the low to mid-60s. sunday you will notice a 10- degree drop in afternoon temperature even though you get the same amount of sunshine. tonight low cloud cover does come back but with the sun coming out even earlier tomorrow we'll be a couple of degrees warmer. watch out for the king tides with tidal flooding this is earlier today. this would be near aquatic park in san francisco. tides running anywhere from two to three feet higher than normal because we're at a new moon and the moon is closer to us this time of year. the final king tide wil
dominant one. and then one off the canadian coastline. the one to our north is taking over. it's does we'll have less onshore flow and more of a north wind. you would think cold with the north wind but this time of year sometimes a north wind just dries us out, less cloud cover, more sunshine making us warmer back in the 70s on friday and saturday. then we get a surge of canadian air. we have been talking about a storm system that will miss us to the east but the counterclockwise flow around...
The Daily Show With Jon Stewart : COM : February 26, 2015 1:04am-1:36am PST
shooting in cuba. we didn't know how long we were going to stay. and immediately canadians, those damn canadians you all know what i'm talking about. the scourge of the world. no the the can neighborhoods started canadian tourists are there and tourists from europe -- >> isn't that the weird part. you go through this thing, you might get killed. you can't get in you have to show your papers. meanwhile, people from the entire rest of the world have been going there forever and are just like "oh hey." >> yeah, but it is a completely different world. it is a world that is frozen in time. my concept of this was i just want to go and meet the people. obviously, it's a politically challengerred situation, but i want to go and do my by-now tired stchick for these people and see if it is amuse glg they seemed to be quite taken. >> i learned to dance there. i learned to -- >> what dance did you learn? >> the rumba. the erotic rumba. >> jon: i think that's actually a vacuum cleaner. i'm pretty sure that's-- >> apparently it's both. apparently it is both. i learned-- i went to a rum factory, beca
shooting in cuba. we didn't know how long we were going to stay. and immediately canadians, those damn canadians you all know what i'm talking about. the scourge of the world. no the the can neighborhoods started canadian tourists are there and tourists from europe -- >> isn't that the weird part. you go through this thing, you might get killed. you can't get in you have to show your papers. meanwhile, people from the entire rest of the world have been going there forever and are just...
toronto. >> it is as canadian as winter itself. all you need is a toe back toboggan and a snow-covered hill and you're off. it's a family affair. >> spending time with the kids, having a good time. going fast. you guys ready? >> yes. >> one two three. >> maybe so, but here in hamilton sliding down a hill like this is illegal. several years ago the city lost a lawsuit brought by a man who broke his back while toboggan tobogganing. the local bye law is to prevent that from happening again. >> we have close to 500 parks some of which present an optimism environment for tobogganing, i.e. they have hills. it's an un uncontrollable situation for us. >> there is a growing backlash led by local musician laurel cole who wrote a protest song ♪ you can't poe toboggan any more ♪ ♪ you can't go out and play ♪ >> i think it's a bigger issue than that. i think it's a culture that we have to stand for and we have to stand for our rights. we choose to slide down hills. as the song says. >> there is no denying tobogganing is risky. two young canadians have died already this winter in acc
toronto. >> it is as canadian as winter itself. all you need is a toe back toboggan and a snow-covered hill and you're off. it's a family affair. >> spending time with the kids, having a good time. going fast. you guys ready? >> yes. >> one two three. >> maybe so, but here in hamilton sliding down a hill like this is illegal. several years ago the city lost a lawsuit brought by a man who broke his back while toboggan tobogganing. the local bye law is to prevent...
Forensic Files : CNNW : February 1, 2015 12:30am-1:01am PST
very proud to be a part of that, quite frankly >>> a small canadian farm town made national news when a woman claimed she was raped by her own doctor. dna tests proved the doctor was innocent. the victim insisted the dna test was wrong. what does a high school graduate know that the world's top scientists do not? nestled along canada's beautiful southwestern prairie is the tiny town of kipling, saskatchewan. the population is so sparse, the farm animals outnumber the residents. in a town this size, everyone knows one another. >> it's a fairly quiet farming community with little crime. we may have up to five or six sexual assaults a year and break and enters, but fairly small in scope of criminal code work. >> this is the story of one of those alleged sexual assault cases. it took place on halloween night in 1992. depending on whose story you believe, it was either a night of lies and trickery or an unfortunate misunderstanding. a woman we'll call candy was working at this gas station. her boyfriend stopped by. they got into an argument. >> i am not dealing with you anymore. >> candy d
very proud to be a part of that, quite frankly >>> a small canadian farm town made national news when a woman claimed she was raped by her own doctor. dna tests proved the doctor was innocent. the victim insisted the dna test was wrong. what does a high school graduate know that the world's top scientists do not? nestled along canada's beautiful southwestern prairie is the tiny town of kipling, saskatchewan. the population is so sparse, the farm animals outnumber the residents. in a...
. the canadian government is calling for the immediate release of fahmy, the al jazeera journalist and canadian citizen has been in jail in egypt 409 with producer mohamed and the foreign minister tweeted prime minister harper personally raised the case of mohamed fahmy but the highest level of egyptian leadership and canadian officials raised the case of mohamed 15 times in the last 9 days and went on this is an upsetting time for the family and continue to call for mohamed mohamed's immediate release and accused of supporting the out lawed muslim brotherhood and they and al jazeera deny and thrown out and the two-phased retrial on thursday and peter greste has been unconditionally released. plus more to come on al jazeera including another air strip used by drugs, trafficics blown up in honduras but it probably won't be long until it's repaired. and in sport extreme cold temperatures are forcing competitors out in the yukon ultra race. ♪ ♪ hello again and let's have a look at the top stories here at al jazeera, pro-russia forces in eastern ukraine say they surrounded the town
. the canadian government is calling for the immediate release of fahmy, the al jazeera journalist and canadian citizen has been in jail in egypt 409 with producer mohamed and the foreign minister tweeted prime minister harper personally raised the case of mohamed fahmy but the highest level of egyptian leadership and canadian officials raised the case of mohamed 15 times in the last 9 days and went on this is an upsetting time for the family and continue to call for mohamed mohamed's immediate...
American History TV : CSPAN3 : February 15, 2015 3:27pm-4:01pm EST
responsibility. they had the royal canadian mounted police escort us about 25 miles, and then we'd go ahead of the procession. at every stoplight, they would pull their cars in front of the traffic and allow us to go through. they did that for us until we got to this place. again on a cliff overlooking the water where we respectfully and appropriately returned our ancestors into the womb of our mother earth. one of the reasons i was asked to come, the karl may museum in germany -- by no we are probably short on time, but they again have ancestral remains in their possession. we requested for repatriation, and it was like dÉjÀ vu all over again, comments being made about the truck backing up to the door of the museum and us cleaning and taking everything that they had. those fears are unfounded as our recent history has shown us. now we are educating them. we are trying to show them that those fears are unfounded. we will be working with them in the near future to work on bringing ancestors home from across the great ocean. miigwich. [applause] >> we do have a few minutes left. first, some
responsibility. they had the royal canadian mounted police escort us about 25 miles, and then we'd go ahead of the procession. at every stoplight, they would pull their cars in front of the traffic and allow us to go through. they did that for us until we got to this place. again on a cliff overlooking the water where we respectfully and appropriately returned our ancestors into the womb of our mother earth. one of the reasons i was asked to come, the karl may museum in germany -- by no we are...
impinged on canadians rights. john terret reports. >> for lee carter, the ruling brings some closure. her mother kay suffered from the dedegenerative disease als. she ask somewhat vindicated. >> this is a case of real people with serious illnesses who through change in law can achieve peace and comfort in knowing they have a choice. >> striking down a 22 year ban on doctor assisted suicide. the nine justices have given federal and provincial governments a year to craft a new law responding to the ruling. failing that the ban will stand. canadian are politician stephen fletcher praised the news. >> this is a momentous day a day we as canadians can celebrate. >> others opposed the marry one doctor telling al jazeera last year it was her job to save lives not take them. >> they want to redefine our profession and want to institute in quebec killing and calling it health care. >> other countries here at home and in the u.s., four states, vermont, montana washington and oregon allow some form of doctor-assisted suicide. >> i will die upstairs in my bedroom i share with my husband with my
impinged on canadians rights. john terret reports. >> for lee carter, the ruling brings some closure. her mother kay suffered from the dedegenerative disease als. she ask somewhat vindicated. >> this is a case of real people with serious illnesses who through change in law can achieve peace and comfort in knowing they have a choice. >> striking down a 22 year ban on doctor assisted suicide. the nine justices have given federal and provincial governments a year to craft a new...
News : ALJAZAM : February 10, 2015 12:00pm-12:31pm EST
has postponed all league matches indefinitely. >>> the canadian government is calling for the immediate release of mohammed fahmy, the al jazeera journalist and canadian citizen has been in jail in cairo for 409 days. along with producer baher -- mohammed fahmy. canadian officials raised the case of baher mohamed 15 times in the last nine days. we continue to call for mohammed fahmy immediate release. they are accused of supporting the outlawed muslim brotherhood. charges they and al jazeera deny. a third al jazeera journalist peter has been released and is now back home in australia. >>> still ahead on the news hour aid for the victims of syria's war, the u.n. chief talks to us about efforts to raise money. >>> celebrations in delhi, as an anti corruption party wins state elections in a huge setback for the prime minister. more on that. stay with us. ♪ >> the stream, >> your digital community >> you pick the hot topics and express your thoughts the stream it's your chance to join the conversation only on al jazeera america ♪ >>> welcome back. a reminder of the headlines h
has postponed all league matches indefinitely. >>> the canadian government is calling for the immediate release of mohammed fahmy, the al jazeera journalist and canadian citizen has been in jail in cairo for 409 days. along with producer baher -- mohammed fahmy. canadian officials raised the case of baher mohamed 15 times in the last nine days. we continue to call for mohammed fahmy immediate release. they are accused of supporting the outlawed muslim brotherhood. charges they and al...
News : ALJAZAM : February 7, 2015 2:00pm-2:31pm EST
as canadian as, well, winter itself. all you need is a toboggan and a snow-covered hill and you're off. it's probably the most popular pastime in this land and it's a family affair. >> having a good time. going fast. you guys ready. ready, one two three. >> maybe so, but here in hamilton sliding down a hill like this is illegal. several years ago the city lost a lawsuit brought by a man who broke his back while tobogganing. the local bye law is an attempt to prevent that from happening again. >> we have close to 500 parks in the city of hamilton. some of which present an optimum environment for tobogganing i.e. they have hills. it's basically an un uncontrollable consideration for us. >> there is a growing backlash by musician laura cole who wrote a song "you can't toboggan in the hammer any more ohio ♪ you're not supposed to run and play ♪ >> she says it's about much more than restricting winter fun. >> i think it's a bigger issue than that. i think it's something as a culture that we have to stand for and we have to stand for our rights. we choose to slide down hills as the s
as canadian as, well, winter itself. all you need is a toboggan and a snow-covered hill and you're off. it's probably the most popular pastime in this land and it's a family affair. >> having a good time. going fast. you guys ready. ready, one two three. >> maybe so, but here in hamilton sliding down a hill like this is illegal. several years ago the city lost a lawsuit brought by a man who broke his back while tobogganing. the local bye law is an attempt to prevent that from...
. >> ready one two three. >> and canadians fight a downhill battle for the right to go at that bog unking. >>> now for the first time in more than 10 years residents of baghdad are being allowed to go out past midnight. right now a nighttime curfew which has been in place in the iraqi capital since 2004, is being lifted as the government tries to normalize life in the city. four neighborhoods in baghdad have also been declared did he mel terrized zones. meaning even people authorizedded to carry weapons will be prohibited from doing so in those areas. the government says it will be removing concrete blast walls and barricades which have blocked the streets. but it still faces significant security problems. earlier a bomb killed at least 40 people in the city n. a moment we hope to speak to our correspondent in baghdad. in the meantime, though, in spite gains in yes rents weeks by kurdish per peshmerga forces mosul is still under isil control. but they have a new plan to try to recapture mows ill. the city is strategic because of its proximity to the mosul dam which controls most the water
. >> ready one two three. >> and canadians fight a downhill battle for the right to go at that bog unking. >>> now for the first time in more than 10 years residents of baghdad are being allowed to go out past midnight. right now a nighttime curfew which has been in place in the iraqi capital since 2004, is being lifted as the government tries to normalize life in the city. four neighborhoods in baghdad have also been declared did he mel terrized zones. meaning even people...
. the canadian government is is callings for immediate release of mohamed fahmy. canadian official raised the case of mohamed fahmy with egyptian officials 15 times in the last nine days. we understand this is an upsetting timing for the family, we continue to call for mohamed fahmy's immediate release. >>> while fahmy and baher mohamed have been accused of supporting the outlawed muslim brotherhood, something they deny. the two-phase retrial this thursday a third al jazeera journalist peter greste has been released unconditionally. >>> the united nations envoy to syria is in town for talks with the government. seeking a truce for the biggest city in the country aleppo. moalem says he plans to push for a freeze in fighting to get aid into the city. at the height of clashes between rebel forces and competing groups. force he made it clear that damascus will not be accepting foreign ground troops in the fight against i.s.i.l. >> i clearly say that we are keen in defending syria's sovereignty. the syrian arab army is carrying out its mission with courage. >> said to have retain areas
. the canadian government is is callings for immediate release of mohamed fahmy. canadian official raised the case of mohamed fahmy with egyptian officials 15 times in the last nine days. we understand this is an upsetting timing for the family, we continue to call for mohamed fahmy's immediate release. >>> while fahmy and baher mohamed have been accused of supporting the outlawed muslim brotherhood, something they deny. the two-phase retrial this thursday a third al jazeera journalist...
Early Start With John Berman and Christine Romans : CNNW : February 27, 2015 2:00am-3:01am PST
about the new york men accused of terror plots. the canadian teens who may be on their way to help isis and the new videos isis is releasing in iraq destroying ancient artifacts for the cameras. team coverage breaking down the big story starts now. i'm christine romans. it is friday february 27th. 5:00 a.m. in the east. john berman has the morning off. a dying prognosis this morning. the fbi counterterrorism official testifying to lawmakers that america is in his words, losing the battle to stop islamist militants from spreading their message online. >> foreign terrorists have direct access to the united states. they know they cannot travel so they put out an effective propaganda message in social media and platforms saying if you can't come to syria, do something in the u.s. or western countries. >> u.s. director of national intelligence james clapper on capitol hill thursday painting the equally grim picture. pamela brown has more on that. >> reporter: good morning, christine. with jihadi john isis high profile recruit, unmasked this morning, they are focusing on new followers he
about the new york men accused of terror plots. the canadian teens who may be on their way to help isis and the new videos isis is releasing in iraq destroying ancient artifacts for the cameras. team coverage breaking down the big story starts now. i'm christine romans. it is friday february 27th. 5:00 a.m. in the east. john berman has the morning off. a dying prognosis this morning. the fbi counterterrorism official testifying to lawmakers that america is in his words, losing the battle to...
WJLA (ABC)
Good Morning America : WJLA : February 14, 2015 7:00am-8:01am EST
by WJLA
holiday dedicated to love. kendis gibson is here with more. >> reporter: canadian authorities say they avoided a massacre, just hours away from taking place. two canadians and one american who are allegedly obsessed with death and mass killing planning to make this a bloody valentine's day. this is the scene where police thwarted a deadly public attack. a 23-year-old female from an upscale chicago suburb along with three men from halifax, nova scotia, planning to storm a canadian mall with fire arms. >> a 19-year-old male and a 23-year-old geneva illinois female, had access to fire arms. it was their intention to go to a public venue in the halifax region on february 14th with the goal of opening fire, to kill citizens, and then themselves. >> reporter: officers received tip about the woman who traveled from the united states to nova skosh scotia canada. >> had they been able to carry out their intentions, the possibility for a large loss of life was definitely there. >> reporter: a potentially horrific valentine's day avoided. and get this we learn overnight that the 19-year-old
holiday dedicated to love. kendis gibson is here with more. >> reporter: canadian authorities say they avoided a massacre, just hours away from taking place. two canadians and one american who are allegedly obsessed with death and mass killing planning to make this a bloody valentine's day. this is the scene where police thwarted a deadly public attack. a 23-year-old female from an upscale chicago suburb along with three men from halifax, nova scotia, planning to storm a canadian mall...
missing canadian teens on the way to help isis and the videos isis is releasing in iraq. team coverage starts right now. good morning. welcome to "early start." i'm christine romans. it is friday february 27th. 4:00 a.m. in the east. john berman has the morning off. we are learning more about the british accented voice that the world has come to know as jihadi john. beyond the nickname believed to be mohammed emwazi. a privileged upbringing in london and a bright middle class future. at the top of the list of questions, why? was it mistreatment by authorities or was he on path to terrorism earlier? we have isa soares live in london with the latest. what are we learning about jihadi john? >> reporter: good morning, christine. the first question many people are asking is how is it possible he was able to evade authorities who had been in contact with him more than a dozen times who had known him for six years. newspapers are asking shocking defense of jihadi john. if i show you the daily telegraph, mi 5 londoners allow jihadi john to slip the net. they questioned him in 2009 whe
missing canadian teens on the way to help isis and the videos isis is releasing in iraq. team coverage starts right now. good morning. welcome to "early start." i'm christine romans. it is friday february 27th. 4:00 a.m. in the east. john berman has the morning off. we are learning more about the british accented voice that the world has come to know as jihadi john. beyond the nickname believed to be mohammed emwazi. a privileged upbringing in london and a bright middle class future....


Lowest Prices for the best trailer spindles from Redline. Agricultural Spindle, 1-3/4" x 5" Stub, 3K part number AS3000F can be ordered online at etrailer.com or call 800-298-8924 for expert service.
Agricultural Trailer Spindle comes complete with nut and washer.
Overall length of spindle: 10"
Today we're going to be taking a look at part number AS3000F. This is Redline's Agricultural Spindle. It's going to offer a capacity of 3,000 pounds. You can see what all it comes with here, I have it all lay down on our table. You're going to get a washer, the cutter pin, the castle nut, and a spindle. All three of these parts right here are going to be used to hold the hub assembly on to the spindle.
Bearings and seals are going to be sold separately but we're going to go over some measurements that will assist you in choosing the correct bearings and seals. You can see that this is a round spindle, again, it's going to have the 3,000 pound capacity.	If we take a measurement of the stub length, it's going to give us a measurement of 5". The overall length, measuring from edge to edge is going to measure right at 10". Next measurements that I'm going to go over, these are measures in hundredths 00:01:10 of an inch. We're going to be using a digital caliper to get our exact readings.
First one's going to be the stub diameter. This portion back here, that's going to be 1.75. The next one's going to be the grease seal. That's going to be 1.75 as well. The next one's going to be inner bearing surface.
It's going to be 1.5. next one's going to be the outer bearing surface. It's going to be 1.25 and then the next one is going to be the threaded portion. That's going to be .75, which would also be 3/4 of an inch.	That's going to do it for today's review of part number AS3000F. This is Redline's Agricultural Spindle.
Do you have a question about this Trailer Spindle?
I wish we did, but we do not carry any 10k rated trailer spindles. The highest we have is a 6k spindle like part # AS3000F. This is an agricultural spindle that could work well on your hay wagon as long as you didn't need more than a 6k capacity. Otherwise we do carry 10k rated hubs, (see link to the right), if you can find the spindles elsewhere.
Although the outer bearing of the # AKIHUB-655-6-K hub assembly will fit, the inner bearing will be too large. Instead, you'll need the Complete Agricultural Hub Assembly, # AH30660FCOMP, which is designed to fit the agricultural spindle # AS3000F. I've attached a couple of review videos for you to check out.
For a spindle that fits the hub part # 8-213-5UC1 you'd want the part # 52655IEU which comes with the 5,200 lb hub you mentioned and the correct matching spindle for you to install. The hub you mentioned will not fit the agricultural spindle you mentioned due to the difference in seal dimensions.
In all honesty it really just boils down to how they were manufactured and what bearings and grease seal are typically found on those axles/spindles. It also may have to do with the part # R50642 being a standard application while the part # AS3000F is geared more towards agricultural applications. Either way, Redline has tested and approved these spindles for the capacities that you references.
The only capacities we have for the two spindles you mentioned is the capacity of them if they are used as they are intended on a trailer axle. The part # AS3000F is for a 6,000 lb axle so it has a 3,000 lb capacity and the # R50642 is intended for a 5,000 lb axle so it has a 2,500 lb capacity.
We do not carry a AS6000F spindle. We do carry the # AS3000F which may be what you meant to type. I attached a pic of it's dimensions.
The spindle you mentioned has a 5,000 lb axle rating so it would not be the correct spindle. We do carry a 6k spindle but it's for agricultural hubs and isn't the correct measurements you need. It's part # AS3000F. The hub you mentioned part # AKIHUB-655-6-K is a 6k hub though so it would work well.
Highest quality trailer spindles for the best price.
Most detailed, accurate trailer spindle information available.


text:
Cockburnspath railway station served the village of Cockburnspath, Berwickshire, Scotland from 1846 to 1951 on the East Coast Main Line.

History
The station opened on 22 June 1846 by the North British Railway. The station building was one-storey and was on a H plan. The station closed on 18 June 1951.

References

External links

Disused railway stations in the Scottish Borders
Former North British Railway stations
Railway stations in Great Britain opened in 1846
Railway stations in Great Britain closed in 1951
1846 establishments in Scotland
1951 disestablishments in Scotland

redpajama_set_name: RedPajamaWikipedia


text:
Permanent Vacation (Album)
Aerosmith studio album
March - May 1987
Label (s)
Format (s)
CD, LP, MC
Genre (s)
Hard rock , blues rock
Title (number)
Vocals, keyboards , harmonica , percussion : Steven Tyler
Guitar: Joe Perry
Guitar: Brad Whitford
Bass: Tom Hamilton
Drums, percussion: Joey Kramer
Studio (s)
Little Mountain Sound Studios, Vancouver (Canada)
Permanent Vacation is the ninth studio album by the US hard rock band Aerosmith . It was released on Geffen Records in August 1987 . Dude (Looks Like a Lady) was released as the lead single, followed by Angel and Rag Doll as further singles .
3 Title List
The album can be seen as a turning point or comeback for Aerosmith following the success of the cover version of Walk This Way by Run-DMC in 1986. It was recorded for the first time with Bruce Fairbairn in the Little Mountain Studios in Vancouver , where the following albums were to be created. In addition, external songwriters such as Desmond Child and Jim Vallance worked for the band for the first time. A cover version of I'm Down was recorded by the Beatles .
According to the certifications, the album sold at least nine million times. It reached number eleven on the Billboard 200 . On the Allmusic.com site , John Franck and Eduardo Rivadavia praised the "mostly outstanding" songwriting . As an overall rating, they certified Permanent Vacation "a guaranteed number of incredible tracks for any time and place" (a guaranteed number of incredible tracks for always and everywhere). However, the successor Pump was rated as even stronger. They awarded four out of five stars. The editors of Rock Hard magazine put the album at 139th place in their list of 500 albums in 2007. Marcus Schleutermann wrote that the band had reported back with a "clap of thunder", he spoke of a "milestone" in the band's history. Only the somewhat "confused end" with the cover I'm Down and the instrumental The Movie was criticized .
Heart's Done Time ( Desmond Child , Perry) - 4:42
Magic Touch (Perry, Tyler, Jim Vallance ) - 4:37
Rag Doll ( Holly Knight , Perry, Tyler, Vallance) - 4:25
Simoriah (Perry, Tyler, Vallance) - 3:22
Dude (Looks Like a Lady) (Child, Perry, Tyler) - 4:24
St. John (Tyler) - 4:10
Hangman Jury (Perry, Tyler, Vallance) - 5:33
Girl Keeps Coming Apart (Perry, Tyler) - 4:13
Angel (Child, Tyler) - 5:08
Permanent Vacation (Tyler, Whitford) - 4:49
I'm Down ( Lennon / McCartney ) - 2:20 ( The Beatles Cover)
The Movie [instrumental] (Hamilton, Kramer, Perry, Tyler, Whitford) - 4:04
Permanent Vacation at Allmusic (English)
^ A b John Franck, Eduardo Rivadavia: Review Permanent Vacation on allmusic.de
↑ Rock Hard (Ed.): Best of Rock and Metal, Heel-Verlag, Königswinter 2007, ISBN 3-89880-517-4 , p. 166
Steven Tyler • Joe Perry • Tom Hamilton • Brad Whitford • Joey Kramer
Raymond Tabano • Jimmy Crespo • Rick Dufay
Aerosmith (1973) • Get Your Wings (1974) • Toys in the Attic (1975) • Rocks (1976) • Draw the Line (1977) • Night in the Ruts (1979) • Rock in a Hard Place (1982) • Done with Mirrors (1982) • Permanent Vacation (1987) • Pump (1989) • Get a Grip (1993) • Nine Lives (1997) • Just Push Play (2001) • Honkin 'on Bobo (2004) • Music from Another Dimension! (2012)
Dream On • Walk This Way • Amazing • Crazy • Nine Lives • I Don't Want to Miss a Thing
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