text:
package org.axonframework.sample.axonbank.myaxonbank;

import org.springframework.amqp.core.Binding;
import org.springframework.amqp.core.FanoutExchange;
import org.springframework.amqp.core.Queue;
import org.springframework.amqp.rabbit.connection.CachingConnectionFactory;
import org.springframework.amqp.rabbit.connection.ConnectionFactory;
import org.springframework.amqp.rabbit.core.RabbitAdmin;
import org.springframework.amqp.rabbit.transaction.RabbitTransactionManager;
import org.springframework.beans.factory.annotation.Autowired;
import org.springframework.beans.factory.annotation.Required;
import org.springframework.context.annotation.Bean;
import org.springframework.context.annotation.Configuration;
import org.springframework.core.env.Environment;

@Configuration
public class RabbitMQConfiguration {

    @Autowired
    private Environment env;

    @Bean
    ConnectionFactory connectionFactory() {
        CachingConnectionFactory cf =
            new CachingConnectionFactory(env.getProperty("spring.rabbitmq.host"));
        cf.setUsername(env.getProperty("spring.rabbitmq.username"));
        cf.setPassword(env.getProperty("spring.rabbitmq.password"));
        cf.setPort(Integer.parseInt(env.getProperty("spring.rabbitmq.port")));
        return cf;
    }

    @Bean
    Queue defaultStream() {
        return new Queue(env.getProperty("spring.application.queue"), true);
    }

    @Bean
    FanoutExchange eventBusExchange() {
        return new FanoutExchange(env.getProperty("spring.application.exchange"), true, false);
    }

    @Bean
    Binding binding() {
        return new Binding(env.getProperty("spring.application.queue"), Binding.DestinationType.QUEUE,
            env.getProperty("spring.application.exchange"), "*.*", null);
    }

    @Bean
    @Required
    RabbitAdmin rabbitAdmin() {
        RabbitAdmin admin = new RabbitAdmin(connectionFactory());
        admin.setAutoStartup(true);
        admin.declareExchange(eventBusExchange());
        admin.declareQueue(defaultStream());
        admin.declareBinding(binding());
        return admin;
    }

    @Bean
    RabbitTransactionManager transactionManager() {
        RabbitTransactionManager rabbitTransactionManager =
            new RabbitTransactionManager(connectionFactory());
        return rabbitTransactionManager;
    }
}

redpajama_set_name: RedPajamaGithub


Ever Wanted to Watch Kurt Russell Smash an Antique Martin Guitar?
For the music industry and especially guitar enthusiasts, Christmas 2015 was a smash hit.
"We were informed that it was an accident on set. We assumed that a scaffolding or something fell on it. We understand that things happen, but at the same time we can't take this lightly."
Martin collectively seemed like they were going to be cool about the whole situation at first... until they found out what really happened.
"You see, what had happened was..."
Quentin Tarantino released his next big movie on Christmas day, called the Hateful Eight. In this movie eight real tough cowboys, cops, criminals, and other Western types all cross paths in the worst of Winter during the Civil War.
The whole crew basically gets locked up in this general store while a storm blows over. Jennifer Jason Leigh's character is a fugitive who's been captured by Kurt Russell. The entire time, she's literally connected to Russel at the wrist with a set of handcuffs. He's constantly smacking her around and all of this brutal stuff. Teeth are coming out and all kinds of crazy Mortal Kombat fatalities.
But then she asks kindly to be unshackled so she can play and sing the Eight a little diddy on a guitar in the cabin. Kurt's like "Cool, we're bored, no harm, no foul." He releases her and she starts fingerpicking away.
And that day, the Grinch's heart grew a little bit larger.
The Martin Guitar Company, on the other hand, now has an icebox where their heart used to be.
"Yeah... you know that 140 year old guitar you guys loaned us out of your museum? You guys are so cool for having done that. Really, great guys over at Martin. Anyhow, we kind of had an accident and banged up the guitar a little bit. I mean... it's pretty much done for. Thanks in advance for your understanding and forgiveness."
I'm sure the Martin fellers were like "Well, what can you do? What's done is done and we don't cry over spilled milk. An accident in the name of art is one worth having." That was until they learned what really happened.
The actual historic Martin guitar as it was in their museum.
"All this about the guitar being smashed being written into the script and that somebody just didn't tell the actor, this is all new information to us. We didn't know anything about the script or Kurt Russell not being told that it was a priceless, irreplaceable artifact from the Martin Museum ... I don't think anything can really remedy this. We've been remunerated for the insurance value, but it's not about the money. It's about the preservation of American musical history and heritage."
Boak has also stated that Martin will no longer loan out their historical artifacts from their museum, for any reason.
Nobody wants these kind of things to happen, but Tarantino's films always capture real moments of magic and include them in the final cut of the movie. Remember when Leonardo DiCaprio shatters that cup in Django Unchained and he gets this crazy look on his face as his hand starts bleeding? That was real. You know what else was real?
The best part of this entire ordeal, beyond the smashing of one of the oldest acoustic guitars left on the planet, is the look in Jennifer Jason Leigh's face as she watched Russell do the deed.
"I hope they have some superglue in this cabin."
If I was Martin, I'd get the pieces of the guitar back and put THAT in the museum as an exhibit.


Jessica Alba is an American actress, model and businesswoman.
Jessica Marie Alba was born on April 28, 1981, in Pomona, California. At the age of 5, Alba knew she wanted to become an actress. At 11, her dreams began to look real when she won the grand prize of an acting competition in Beverly Hills, California. She then began to take free acting lessons which were the grand prize of the competition she had won.
Alba in 1994 received her debut film role in a feature film titled "Camp Nowhere". She then appeared in a number of independent films before branching into Television series. Her debut TV role was in Nickelodeon series "The Secret World of Alex Mack". Her other roles in TV would include "Flipper", "Brooklyn South", "Beverly Hills", "90210" among others.
Alba's Hollywood reputation surged when she starred in the romantic comedy "Never Been Kissed" (1999). But the big break came in 2000 when she was selected to star in James Cameron's Fox sci-fi series "Dark Angel". The series lasted two seasons and earned her a Golden Globe nomination. Alba has since gone ahead to establish herself as a Hollywood star. Some of her notable movies include; Honey (2003), Sin City (2005), Fantastic Four and its sequels, Good Luck Chuck (2007), Valentine's Day (2010) among others.
While Alba may be better known as a Hollywood actress, it is her remarkable business acumen that has earned her the multi-millionaire status. In 2011, Alba, in her search for safe, non-toxic products for herself and her baby, co-founded a nontoxic-household-goods startup called The Honest Company. The company which began as an e-commerce subscription service solely selling baby products have now expanded to include over a hundred other items.
In 2014, the company raised $70 million from a private equity firm to raise its valuation to $1 billion and in August 2015, after raising another $100 million, its valuation surged to $1.7 billion while Alba who owns 20% of the company saw her net worth equally rise to around $350 million. Thus, making her one of the richest entrepreneurs under 40.
The company also includes Honest Beauty, an 80-piece makeup and skin care line with a transparent ingredient list. The success of the company doesn't seem to be slowing down, and its IPO launch seems nearer by the day. On the other hand, Alba manages to keep her show business active.
Jessica is the daughter of Catherine Louisa (née Jensen) of Danish, Welsh, German, English, and French ancestry and Mark David Alba of Mexican descent. She got married to Cash Warren on May 19, 2008, but was first engaged to Michael Weatherly, her co-star who proposed to her on her twentieth birthday in 2001. The engagement was shortlived as in August 2003, they both announced that they have ended their relationship.
Alba now shares three children with Cash Warren. Her two daughters' names are Honor Marie Warren (born 2008) and Haven Garner Warren (born 2011) while her third child, a son Hayes Alba Warren was born on December 31, 2017. She released the news of their newborn on January 1, 2018, at the beginning of the new year. Alba was paid $1.5 million in 2008 to release the first photos of her first daughter on OK! Magazine.
The simple yet classy actress recently bought for herself and family a mega-mansion worth about $10 million. The mansion which is described as "East Coast-inspired Hamptons traditional" is located at Beverly Hills Post Office. The 1.85-acre property has a detached guest house and an 8,829-square-foot main house as well as a charming one-bedroom, one-bathroom guest cottage.
Jessica Alber's new place is right next to Real Housewives Of Beverly Hills' star Lisa Vanderpump's mansion known as Villa Rosa. It was purchased with the help of Alber's father, David Alba who is a real estate agent.
Owing to her gracious looks and well-maintained body, Jessica has received the attention from several publications listing her as one of the most beautiful and attractive celebrities. With her 5 ft 7in height, Jessica keeps a weight of 56kg (123.5 pounds). She maintains a body measurement of 34-24-34in which drives most of her male fans nuts.
In fact, a report emerged in 2010 about a 21-year-old Chinese girl who wanted to undergo a plastic surgery to look like Alba in order to win back an ex-boyfriend. Jessica frowned at this, urging the lady to not change her looks because of love.
Explaining how she maintains her natural beauty, the American model said it was possible with the help of good exercise, meditation and healthy eating. At the early hours of each day, the star goes for a spin class or hot yoga to keep fit. Her bra size is 34B and the size of shoe that fits her feet is 8.


text:
borovsky 298.88.(Photo by: Ariel Jerozolimski)
Behind the Lines: Out of comptroll
The new style of the Comptroller's Office has made remaining impartial much more difficult than usual.
'Of course [former commander Yaakov] Borovsky promised politicians favors in return for their support," the director of a large non-governmental organization (with high-level contacts in the government and legal establishment) told me this week. "He also asked us for help. But there was nothing strange about that. All the contenders for police inspector-general were doing the same thing. Why should he have been any different?" But the results of the investigation into whether or not Borovsky offered Likud politicians a deal (that if appointed, he would replace the team investigating charges of corruption against prime minister Ariel Sharon and his sons) are not that important. If he is found guilty, it will only prove what much of the public already suspects about law enforcement in this country: that investigations are more about personal ambition and political pressure than they are about the pursuit of truth and justice. The real question is how the scandal surrounding Borovsky will affect his present boss, State Comptroller Micha Lindenstrauss. You don't have to be a political analyst to understand why the story is only emerging now, two and a half years after Borovsky was passed over in favor of Moshe Karadi, who was not even seen as a candidate for top cop. Since the rumors surrounding Ehud Olmert's real estate dealings surfaced nine months ago, a war had been raging between Lindenstrauss and the prime minister. Lindenstrauss has repeatedly angered Olmert by not only being eager to investigate each new allegation of wrongdoing, but by notifying the press in the process. The two also managed to clash openly when Lindenstrauss refused Olmert's proposal to be in charge of investigating the response of civil authorities to the bombardment of the North during this summer's war, announcing instead that his own office would conduct an independent investigation into all aspects of the war. Borovsky is Lindenstrauss's special adviser on corruption in high places - in effect, the comptroller's right-hand man in the campaign to clean up public life in Israel. Borovsky countered the story of his alleged corruption by saying, "I never would have been accused if I weren't leading these probes into the prime minister's affairs." That the reporter who first revealed the story was Channel 1's diplomatic correspondent, Ayala Hasson, is indeed indicative. Hasson has enjoyed a particularly good relationship with the Prime Minister's Office since Sharon's tenure. She even admitted as much, when she said on the radio: "Of course, every source has his own interest in passing on information [to the media], but it's our job to follow these leads, no matter what." Whether or not Borovsky's lobbying for a desired job turns out to have been illegal, the investigation does pose a problem for Lindenstrauss. In more than three decades as a judge - from traffic court and beyond - he had ample opportunity to observe police work up close. As president of the Haifa District Court, he should have been closely acquainted with Northern District commander Borovsky and his old-school methods. Even if he wasn't aware of Borovsky's allegedly illegal political machinations, Lindenstrauss should have realized that by appointing him to the hitherto non-existent post of "corruption czar," he might be erecting a "glass house" around the comptroller's office - one easily susceptible to the throwing of stones. COMPARED TO leak-prone organizations such as the police, the State Comptroller's Office has always been a relatively impenetrable institution. Ironically, over the years, its refusal to comment on ongoing probes has served many journalists well. This is because the comptroller is required to pass preliminary reports on to the relevant ministries for comment. Once in the hands of these ministries, the reports were often leaked, allowing lucky reporters to publish the information and pass it off as the result of investigative journalism. Lindenstrauss, however, isn't prepared to relinquish the credit for the publication of such information. Upon assuming his post in July 2005, he made it clear that he saw the media as his partner in his "no compromise, no holds barred" battle against corruption. Though Lindenstrauss himself rarely gives interviews, Borovsky has talked to the press on a regular basis, always managing to drop interesting hints. LINDENSTRAUSS'S FOSTERING of a good relationship with the media and his deepening conflict with Olmert have created a unique dilemma for some reporters, who were not used to regarding the comptroller as a combatant. Journalists should be able to utilize leaks to maximum effect, but in this case, quite a few found themselves taking sides, not always out of choice. Journalism is all about biting the hand that feeds you and then coming back for more, but the new style of the Comptroller's Office has made remaining impartial much more difficult than usual. There have always been some journalists disposed toward the government and others with a confrontational agenda. More balanced reporters, however, are now having trouble assessing the validity of the mounting allegations of corruption against Olmert and other senior politicians, while accepting that there are considerable merits to the counter-accusation against Lindenstrauss: that he has been exhibiting no small degree of megalomania and overstepping his mandate. Last week's "professors' letter" has only further muddied the waters. Five leading experts on Israeli law and political science signed an open letter headlined: "Judge Micha Lindenstrauss is harming the order of government in Israel." The professors, all veteran academics with impeccable establishment credentials, castigated Lindenstrauss for the leaks from his office and for exceeding his mandate by intruding in criminal investigations. For one of the signatories, Herzliya Inter-Disciplinary Center president Amnon Rubinstein, this is only another in a series of blistering attacks against members of the legal establishment. Three months ago, he recommended that former chief justice of the Supreme Court, Meir Shamgar, be reappointed to his post - instead of giving it to Dorit Beinish - to enable a comprehensive reform of the judiciary and the restoration of its public stature. This week, in an interview with The Jerusalem Post, he called for an urgent overhaul of the Attorney-General's Office, in the wake of the growing scandal surrounding the Haim Ramon sexual harassment case. Such attacks haven't seemed to cause Lindenstrauss to swerve in his crusade. But then, he was never one to accept criticism. Four years ago, he spearheaded the judges' stiff opposition to the Bar Association's annual questionnaire that assesses their performance on the bench. He advocated support for the controversial decision on the judges' part to boycott all Bar Association events. Still, he can't be oblivious to what's been happening around him, particularly during the past two weeks. First there was the Borovsky scandal. Then the "professors' letter." Finally, on Monday, there was his report on campaign financing. Someone leaked in advance to the press that the report would cause serious damage to Vice Premier Shimon Peres, accused of receiving $320,000 in illegal donations from three foreign businessmen. But the hype was seen as unjustified when it transpired that the comptroller couldn't accuse Peres of anything worse than acting against the norm by using a loophole in the current laws. As serious as this may be, it wasn't illegal and it didn't live up to the high expectations raised by Lindenstrauss's circle. Media-management, it turns out, is trickier than it seems. Olmert, on the other hand, is a master of the craft. In a friendly interview with Channel 2's Yair Lapid, he deftly evaded questions on his feelings toward Lindenstrauss, while obliquely referring to the "professors' letter." FOR MONTHS it seemed as though the ugly atmosphere surrounding the mismanagement of the war and incessant allegations of corruption would bring the government down sooner than later. But the squabbling between Defense Minister Amir Peretz and Chief of Staff Dan Halutz over senior IDF appointments; Labor Party infighting over Avigdor Lieberman's joining the government; and now the comptroller controversy are causing public attention to move in other, more pressing directions. The tug-of-war between Olmert and Lindenstrauss might make many Israelis wish a pox on both of their houses, but that won't serve to clean the atmosphere. Whether or not the allegations against the prime minister are the result of an orchestrated smear campaign - as Olmert claimed this week - someone has to get to the bottom of the mess. But all participants in it - the courts, the attorney general, the state comptroller, the police and the media - seem to be doing everything in their power to lose credibility. anshel@ejemm.com

redpajama_set_name: RedPajamaCommonCrawl


text:
A Ribeira do Hospital é um curso de água português, localizado na freguesia açoriana de Santa Bárbara, concelho de Angra do Heroísmo, ilha Terceira, arquipélago dos Açores.

Este curso de água encontra-se geograficamente localizado na parte Oeste da ilha Terceira e tem a sua origem nos contrafortes do vulcão da Serra de Santa Bárbara, a maior formação geológica da ilha Terceira que se eleva a 1021 metros acima do nível do mar e faz parte de bacia hidrográfica gerada pela própria montanha e divide a freguesia de Santa Bárbara da freguesia das Cinco Ribeiras.

Ver também
 Lista de ribeiras de Portugal

Referências
 Mapa dos Açores, Série Regional, 5º Edição ISBN 978-989-556-071-4

Angra do Heroísmo
Hospital

redpajama_set_name: RedPajamaWikipedia


Network Rail performed its first drone survey last Friday on the southwestern rail route near Bournemouth, England. The drone made its first flight to survey a trespass hotspot, looking to record anyone risking their lives on the train tracks.
The specially designed drone is equipped with a high-tech heat sensitive 4k camera to spot changes in temperature. This helps to identify people and potential damage to the infrastructure. It will also allow inspections to be carried out by air without closing railway. Using a drone also means a reduction in the number of times engineers are sent onto the tracks. This improves safety.
The drone will fly up to 120 meters high at speeds of up to 50 miles per hour. The images it takes are displayed on the operator's screen and recorded directly to a USB drive so they can then be immediately transferred to British Transport Police and other authorities as necessary.


text:
Terrace é um município canadense da província de Colúmbia Britânica. Sua população, segundo o censo de 2001, era de 12.109 habitantes.

Ligações externas
 Site oficial do município
 Site de turismo de Terrace

Cidades da Colúmbia Britânica


text:
italian pasta food truck
Search Fee of Health Products Regulatory Authority database Notification of changes to the register of Brokers of finished medicinal products Appeal to a decision of the Authority of the HPRA (refundable if successful) 1.13 National Scientific Advice 1.14 Classification Quality or preclinical development only Clinical development only To support small and medium-sized enterprises (SME, <250 employees and 50 million euros annual . For scientific advice and protocol assistance: the cut-off point will be the date of validation of the request for advice. For more information, see fees payable to EMA. 5.Explanation for asterisks is missing4 The EMA has decided to waive all fees for scientific advice for academic researchers developing orphan medicines, to further encourage the development of treatments for rare diseases. Fees may vary in isolated cases. Regulatory agencies, including the Food and Drug Administration (FDA) and European Medicines Agency (EMA), and many health technology assessment (HTA) groups offer scientific advice, for a fee, to pharmaceutical manufacturers to elicit input on their clinical and economic evidence generation plans during the drug development process. Support to medicines innovation at National level National Competent Authorities (NCAs) responsible for key tasks, including − Authorisation and Good Manufacturing and Lab Practices − Clinical trial authorisation − ATMPs Hospital Exemption − Compassionate use − NCAs scientific advice (fees might apply) − NCA's Innovation Offices: specific schemes/services (fees might apply) It determines that scientific advice and scientific services for designated orphan medicines shall be provided by the EMA to SMEs free of charge. The parallel scientific advice (PSA) process . July 2021 . EMA - Academia fee waiver for scientific advice 23rd June 2020 The EMA is pleased to inform you about the decision to waive all fees for scientific advice for academic researchers developing orphan medicines, to further encourage the development of treatments for rare diseases. It should be noted that . European Commission) in all 28 member states of the EU • EEA countries (Iceland, Norway and Liechtenstein) also adopt the EC decision This fee is non-refundable and will be credited against the application fee, provided the application is received within the agreed time slot. Q&A. The sooner it can be shown that a new medicine works and is safe, the sooner it can be made available to patients; 1. To further encourage the development of treatments for rare diseases, EMA will waive all fees for scientific advice for academia developing orphan medicines. The EMA said it will provide the free advice to higher education . In contrast, in the US, the Food and Drug Administr. Scientific Advice and Dialogue with EMA during Drug Development. EMA scientific advice guidance document for further details. The labelling of questions is a guide , but does not prevent interested bodies . The academic sector plays an essential role in the development of innovative medicines, which can also benefit patients with rare diseases. This will give scientific advice from NICE in similar timelines to the European Medicines Agency (EMA) process. Some HTA bodies may charge fees for participating in the Parallel Consultation procedure. Numbers of scientific advice and protocol assistance requests to the EMA Source: EMA annual reports 2001, 2004, 2007, 2010, 2013, 2018 and 2019 5-11 It is worth noting that EMA does not offer scientific advice to the academia. Reductions apply for certain types of medicines and applicants, including a 75% fee reduction for medicines for orphan medicines and a 90% fee reduction for SMEs. Fee exemptions for certain administrative services (excluding parallel distribution). This sets MHRA apart from EMA, which offers discounted or free scientific advice as well as oth-er avenues of support for orphan drug developers. As of 1 January 2021, a waiver from scientific advice fees is available to UK based Small and Medium-Sized Enterprises as set out in the Human Medicines (Amendment etc.) The EMA mark is filed in the category of Computer Product, Electrical & Scientific Products.The legal correspondent for EMA trademark is David J. Byer, K&L GATES LLP, ONE LINCOLN STREET State Street . EMA typically charges fees ranging from €43,700-€87,600 ($48,430-$97,080) for scientific advice, though small- and medium-sized entities and orphan product developers are eligible for reduced fees. For more information, see fees payable to EMA. As of August 2021, these fees ranged from €44,400 to €89,000 (about $52,500 to $105,300), though fee reductions are available for orphan drugs and small businesses. Scientific Advice in IRIS. some. EMA: Scientific Advice, Fee Waivers, Faster Reviews Available for Export-Only Drugs February 14, 2017 The EMA detailed the resources available for drugmakers seeking approvals of drugs that are intended for markets outside the European Union in a three-page guideline. It should be highlighted in the subject heading that the submission concerns a request for scientific or procedural advice. • As with FDA, EMA Scientific Advice procedure is data driven and science-based • Complying with SA recommendations can increase chance of positive outcome • As global drug development becomes more complex, coordination of discussion between authorities is critical, but addressing their concerns is challenging EMA's scope and the fees it charges for this procedure are the same as for standard scientific advice. EMA has provided a catalyst to identify priority areas where regulatory requirements pose a challenge for academics and their networks. Scientific advice (SA) is a fee-based voluntary service conferred by regulatory agencies to companies seeking expert opinion while developing new medicinal products. Camargo is known for its expertise in the 505(b)(2) pathway. Example: for a multidisciplinary EMA scientific advice procedure, SMEs pay a fee of around 8,000 Euro instead of 80,000 Euro for non-SMEs. Active substance manufacturers: fees. Fee reductions are applicable on status. Emer Cooke, executive director of the European Medicines Agency, has offered some insights into how the agency's working may change following the COVID-19 pandemic, including the development of hybrid inspections. The request for advice should be submitted in electronic •Similar to EMA Scientific Advice Meeting Fees. Trademark Serial Number is a unique ID to identify the EMA mark in USPTO. This replaces the parallel advice service we delivered with the EMA. Other incentives provided specifically for the development of ATMPs include the following: a 65% fee reduction for a scientific advice request (or 90% for organizations registered with the EMA as micro-, small-, and medium-sized enterprises [SMEs]); and, also for SMEs, a 90% fee reduction for the ATMP certification procedure, which involves the . The EMA has since 2005 made efforts to develop its scientific advice as a service that pharmaceutical companies have to pay for (8,9). On 29 March 2006, the European Parliament adopted • The EMA operates a parallel Scientific Advice Service with the FDA on request. National scientific advice is, however, a faster and more readily available supplement to EMA's procedure and an offer to academic research groups. The costs can be found in the cost regulation of the Paul-Ehrlich-Institut (Section 8 (2)). A request for advice must be sent to the EMA if the marketing authorisation application has already been submitted to the centralised procedure. EMA provides scientific advice because: better designed studies are more likely to generate robust and complete data to show whether or not a medicine works and is safe. This application is open to both U.S.-based and . A common briefing document is used; each question can be addressed to the regulators or the HTABs alone, or to both. Their scientific research is often at the source of novel methodologies and innovative medicines . While the reduced fees and cost-reduced or free scientific advice is only for SMEs in the EEA, EMA and the US Food and Drug Administration do have a program to provide parallel scientific advice to sponsors. We note that the EMA already charges for providing scientific advice . • ~43% of major objections for SME applications are on clinical issues: - SA on Primary endpoints, statistics and comparator should be sought 11 Scientific Advice Working Party Incentives and Benefits • SME fee waiver available • PA for orphan drugs - no fee • Paediatric only developments - no fee • Advices are peer reviewed by . 108 demand from EMA Scientific Advice Office . The European Medicines Agency (EMA) charges fees for the services it provides. The fees, fee exemptions and definitions described in this explanatory note are based on Council Regulation (EC) No 297/95 of 10.02.1995 on fees payable to the European Medicines Agency1 and its 15 The EMA trademark was assigned a Serial Number # 87759200 - by the United States Patent and Trademark Office (USPTO). In its scientific advice the EMA has supported the Company's view to continue the development of efti in MBC in a Phase III clinical trial, based on clinical data presented in December 2020 at . parallel scientific advice from EMA and an HTA is that there is potential for conflicting regulatory versus affordability recommendations. There is no limit to the number of times a sponsor can request this service. The European Medicines Agency's hefty scientific advice fee has discouraged those in the academic sector from getting early regulatory advice on new medicines for rare diseases. EMA's Emer Cooke On The Future Of Rolling Reviews & The End Of Remote Meetings. The fees, fee exemptions and definitions described in this explanatory note are based on Council Regulation (EC) No 297/95 of 10.02.1995 on fees payable to the European Medicines Agency1 and its Another operating model is one whereby the regulators and payers/HTA agencies apply a fee for scientific advice. * ema - provides full fee waivers for scientific advice applications from developers of potential therapeutics or vaccines against coronavirus disease 1.Pre-submission consultations in veterinary Scientific Advice3. Depending on time and effort, the fee is on average between 2000-4000 € per Scientific Advice. The EU Regulatory Environment. are fee based and may present considerable preparation time and expense to the . To benefit from any fee incentives, the SME status has to be assigned by EMA's SME Office before a regulatory submission. Each disease affects only a small proportion of the population, often starting at birth or during infancy. We ran this together . Especially, fee reductions can be significant incentives for SMEs. The European Medicines Agency (EMA) will waive all fees for the provision of scientific advice to applicants from academia developing medicines for the treatment of rare diseases. While this might address their cost issues, it might not . Following our departure from the European Union, we're offering a new concurrent advice service. Free/reduced fee Joint Advice COMP and OOPD Free and reduced fee scientific advice and . Most EMA Scientific Advice is via written response • The exception to the rules is Paul Ehrlich Institute in Germany (biotech, gene, cellular therapies) with lead times of up to 6 -8 months. This EU Regulation is dated Jul. • Fees are another important point to keep in mind, especially EMA € 83,400. EMA) • 1 Review process with 2 independent primary reviewers (via . EMA and EUnetHTA 21 provide common templates which medicine developers should use to provide information and questions as part of the procedure. Center for Biologics Evaluation and Research SOPP 8001.6 Page 1 of 8 SOPP 8001.6: Procedures for Parallel Scientific Advice with European Medicines Agency (EMA) The academic sector plays an important role in the development of innovative medicines . Application for registration. 2.EEA/non-EEA important for SME fee reduction3. But, in a global pharmaceutical business, many clients are looking to develop drugs for both the US and EU markets. On 1 April 2018 general, non-pharmacovigilance fees payable to EMA by applicants and marketing-authorisation holders (MAH) increased 1.7%. the payment of fees to, and receipt of assistance from, the EMA by micro, small and medium-sized enterprises (SMEs). Explanatory note on general fees payable to the European Medicines Agency EMA/364453/2021 Page 2/86 1 Official Journal L35, 15.02.1995, p. 1 2 Official Journal L189, 27.06.2014, p. 112. EMA's scope and the fees charged for this procedure are the same as for standard scientific advice. essential scientific and technical competences required and appoint a c oordinator either from the CHMP or the SAWP who will be in charge of the procedure and a qualification team of experts based upon a proposal elaborated by the EMA scientific advice office in conjunction with the CHMP and SAWP Chairs. Scientific Advice3. FDA also offers reduced user fees to SMEs through the Small Business Designation. ation (FDA) makes advice procedure including the name and address of the applicant as well as the description of the product. Booking fees for DCP applications where Ireland is the RMS A booking fee of €1,000 is applicable to DCP applications where Ireland is the RMS and where commencement periods are pre-agreed. Number of joint early payer scientific advice procedures (EMA-HTA parallel, SEED, EUnetHTA) which involved either the G-BA and/or NICE 18 7 42 14 7 71 12 7 134 17 11 101 10 30 133 0 20 40 60 80 100 120 140 NICE EMA-HTA . For more information, see Fees payable to EMA. The fees apply to both initial and follow-up . Advice within the framework of DKTK and DZIF A European Medicines Agency pilot scheme offering tailored scientific advice on biosimilar development has been viewed by applicants as a "valuable opportunity" and the process will continue as part of regular operations, according to an agency report. EMA says that not every request will qualify for rapid advice and that it will still provide scientific advice within the standard timeframes for other requests. If considering more than 5 HTABs, . Fee reductions for scientific advice, scientific services and inspections (90% fee reduction). • CHMP endorses quality, pre-clinical and clinical development answers • COMP endorses Significant Benefit answers. EMA's scope and the fees charged for this procedure are the same as for standard scientific advice. The 1.7% increase applies to applicants' and marketing authorization holders' general fees payable to EMA. Scientific advice is an important tool in the medicine regulatory lifecycle (1, 2).The European Medicines Agency (EMA) began offering scientific advice in 1996 to provide guidance to medicine developers on all aspects of the development programme from quality of the manufacturing process, to non-clinical and clinical aspects including methodological issues. The agency acknowledged that its fees for protocol assistance present a hurdle for such institutions, but said it believes early interaction with them is important to promote new orphan drugs. EMA Fees See 1.7% Increase. European Medicines Agency (EMA) was established by EU Regulation 2309/93, where the goal of the EMA was to coordinate the evaluation of scientific data associated with the approval, manufacturing, and inspection of medicines in the EU ( 24 ). vice. Academics identified, through a targeted consultation, the fees payable to the EMA for scientific advice as a hurdle to be addressed as a priority. National healthy authorities charge per hour for time to review and meet. CHMP = Committee for Human Medicinal Products) • Single scientific opinion • 1 common Product Information • 1 EU-wide license (via . The EUnetHTA ED Secretariat can provide information on HTA associated fees. Why does EMA provide scientific advice? Fees for advice procedures regarding medicinal products for the treatment of the acute infectious disease COVID-19 are currently waived. September 28, 2020 2 minutes to read. SA allows early communication between the companies and the . European Medicines Agency. The agency previously announced it would fully waive fees for scientific advice to companies developing drugs or vaccines for COVID-19 (RELATED: EMA offers free scientific advice for . The European Medicines Agency (EMA) offers scientific advice to companies involved in developing medicinal products. £1,863. The EMA charges fees for scientific advice meetings depending on the scope of the advice. For instance, in The UK will continue to "offer incentives in the form of market exclusivity and full or partial refunds for marketing authorisation fees to encourage the de- About 85 percent of EMA's budget comes from fees and administrative charges paid by companies to support the agency's review of medicinal products. Enclosure to the cover letter is the application form. Fee waivers to incentivize academia-led innovation. If scientific advice has been previously sought from the European Medicines Agency (EMA), a new request concerning the same product should be first addressed to the EMA. It is still possible for non-EU SMEs to obtain the benefits of EMA scientific advice fee reduction without the cost of setting up an EU entity. 4.Are financial reference and contact points mandatory?4. During SA, regulatory experts respond to specific questions related to the development of a particular medicine. . This simple, low-cost activity can be completed in 6 weeks or less and can confer . essential scientific and technical competences required and appoint a c oordinator either from the CHMP or the SAWP who will be in charge of the procedure and a Qualification team of experts based upon a proposal elaborated by the EMA Scientific Advice Office in conjunction with the CHM P and SAWP Chairs. The European Medicines Agency has been told that its confidential discussions with drugmakers on their development plans for new medicines in exchange for fees presents a threat to the independence of pricing and reimbursement decisions. 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Publisher: Broomall, Penn. : Mason Crest Publishers, c2011.
Phys. Desc.: 48 p. : ill. (chiefly col.), col. maps ; 31 cm.
Publisher: North Mankato, Minn. : Capstone Press, c2012.
Publisher: Layton, Utah : G. Smith, Publisher, c2003.
Phys. Desc.: 1 online resource (190 p.) : ill.
Publisher: Seattle, WA : Mountaineers Books, c2001.
Phys. Desc.: 157 p. : ill., maps ; 22 cm.
Publisher: Prince Frederick, Md. : Recorded Books ; 2011, p1998.


It's been banned from the Buckingham Palace kitchen.
Queen Elizabeth II is a well-known food fanatic. As Travel + Leisure previously reported, the Queen is quite fond of chocolate biscuit cake — so much so that she refuses to travel even a short distance without a slice of it with her.
But it turns out, there is one ingredient the Queen despises so much it has been entirely banned from Buckingham Palace. And that loathed food is garlic.
According to Higgins, the garlic ban is so well-known that if a chef claims to have ever cooked for the Queen, he can check for a lack of garlic as a marker of authenticity.
Beyond garlic, Higgins also shared that the Queen is particular about the way food is prepared for her beloved corgis. In fact, it's a lesson Higgins said he learned the hard way after putting rabbit through a grinder, rather than hand-dicing the meat.
And Higgins, like chefs before him, verified that the Queen does indeed have a rather strong sweet tooth.
"The Queen really enjoyed mangoes. She could tell you how many mangos were in the fridge at Buckingham Palace," he said, adding that she has also been known to indulge in his chocolate mousse.
"Trust me. The plates were clean when they came back from the royal family," he said.


Sahloknir is a leveled dragon brought back from the grave by Alduin east of Kynesgrove. Depending on what type of dragon he is, he can breathe either fire or frost.
Sah Lok Nir translates to "Phantom Sky Hunt".
"I am Sahloknir! Hear my Voice and despair!"
"Thurri du hin sille ko Sovngarde!"
"Your Voice is strong … for a mortal."
"Dohaviin [sic], your Voice is no match for mine!"
"My lord Alduin requires your death. I am glad to oblige him."
"My Voice has been silent for too long!"
"I see that mortals have become arrogant while I slept."
If spoken to, he uses the same line of dialogue as other named dragons who have yet to be resurrected from a burial mound by Alduin: "Speak, if you have aught to say worth the listening."
He is unaffected by the Bend Will shout and cannot be ridden.
This page was last modified on 19 November 2016, at 17:08.


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Commanders' Ron Rivera To Match Donations Made In Honor Of Late Mother
By Jason Hall
Washington Commanders head coach Ron Rivera is vowing to match donations made in memory of his mother, Dolores Rivera, to St. Jude Children's Research Hospital following her death earlier this week.
Rivera, who had previously battled cancer and had lost his older brother to the disease, announced his intention to match donations of up to $100,000 toward a cure for childhood cancer, a special cause to his late mother.
"My family has dealt with a lot of cancer, but mom would say the worst is childhood cancer," Rivera tweeted along with a photo of himself alongside his late mother. "My mom had a beautiful life and she would want a child to have the same. If you click this link & donate, I will match up to $100,000 to St Jude Hospital."
The Commanders announced Dolores' death on Tuesday (November 1) after the head coach was reported to be absent from practice due to a "personal matter" concerning his mother.
"We are saddened to announce that Coach Rivera's mother Dolores passed away peacefully yesterday evening with her husband and family members by her side," the team said in a statement shared on its verified Twitter account.
"Coach Rivera is grateful he was able to spend two days with her last week. The Snyders and the entire Commanders family extend their heartfelt condolences to Coach Rivera and his family.
"The Rivera family would like to say thank you for the many kind thoughts and prayers they have received. Arrangements are pending, and we would ask everyone to please respect the family's privacy during this difficult time."
Ron Rivera underwent his final cancer treatment at a Virginia hospital in October 2020, just hours after the Commanders' 25-3 home victory against the Dallas Cowboys.
Rivera received his last round of chemotherapy and proton therapy, which concluded seven weeks of treatment after initially announcing he was diagnosed with lymph node cancer in August 2020.
Donations to St. Jude's made in memory of Dolores Rivers can be made through the charity's website.


text:
THE TRIBUNE SPECIALS
50 YEARS OF INDEPENDENCE
TERCENTENARY CELEBRATIONS
M A I N N E W S
Keep winning streak, Modi tells BJP
PM accuses Congress, Mulayam's SP of indulging in vote-bank politics
Vibha Sharma
Different and tough yardsticks are being applied to gauge the government's performance. Those who have not done anything for 60 years are asking for our account of 60 days.
Narendra Modi, prime minister
PM's view on WTO stand
Modi likened his government's recent stand at the WTO to the nuclear tests at Pokharan during former Prime Minister Atal Behari Vajpayee's regime
He said for the BJP, the country's prestige was more important than what the world thought of the party
New Delhi, August 9
As the BJP leadership heaped praise on its new president Amit Shah and the NDA government's 60-day achievements, the message for party delegates at the first National Council meeting after assuming power at the Centre was that the winning pace had to be maintained.
While Prime Minister Narendra Modi called Shah the Man of the Match, former BJP president Rajnath Singh referred to him as captain of the party's spectacular Lok Sabha win.
Modi led a veiled attack on the Congress, accusing it and the ruling Samajwadi Party in Uttar Pradesh of continuing to practise vote-bank politics to divide the society and not doing anything substantial for the country in the past 60 years. Shah made an appeal for a Congress-free India.
The outgoing BJP president Rajnath Singh said the BJP was the only cadre and ideology-based party in the country. "The Congress has neither ideology nor cadre," Singh said.
Modi's indirect attack on Congress vice president Rahul Gandhi for his comments that communal clashes in Uttar Pradesh were "artificially engineered" was followed by a direction to cadres "to play a crucial role in ensuring communal harmony and national unity so that the nation moves forward".
"Those who have suffered a massive defeat in the elections are still not able to desist from engaging in old vote-bank politics. They are engaged in disturbing the social fabric," he said.
"The BJP never accepts incidents (of violence) which are taking place in the country. Peace, unity and harmony are the pre-requisites for progress and there will be no compromise on this," he added. Gandhi, who stormed the Well of the Lok Sabha demanding a debate on the rising communal violence, termed violence in UP "artificially and deliberately engineered", triggering a war of words between the two parties, both accusing each other of indulging in "communal politics". Modi talked of how "different and tough yardsticks were being applied" to gauge BJP's performance. "Those who have not done anything for 60 years are asking for our account of 60 days", he said attacking the Congress again.
He likened his government's recent stand at the WTO to the nuclear tests at Pokharan during former Prime Minister Atal Behari Vajpayee's regime, saying for the BJP the country's prestige and the welfare of the poor were more important than what the world thought of the party.
Finance Minister Arun Jaitley tore into the Congress, alleging the rival party's policies were a "liability" when it was in power. Even as an Opposition it was attempting to "create obstacles" so that the NDA government cannot achieve progress, he said.


text:
How Old is
Your Cat?
Adult Cat
Select a stage on the timeline to view more content.
Give Your Kitten a Shot at Good Health
By Samantha Drake
Timely vaccinations are an important part of ensuring the health of your kitten. Kitten owners should bring their new pet to the veterinarian for its first round of shots, which will be followed by another set of vaccinations a few weeks later.
"Vaccines stimulate the kitten's immune system to make antibodies against infection. The diseases a kitten is vaccinated against are either potentially fatal or carry a high risk of infection," according to petMD. Previous vaccinations, age, and whether the kitten will go outside or not all factor into which vaccinations your kitten should receive.
Kittens younger than eight weeks should not be vaccinated because they are already being protected against disease by the natural antibodies in their mother's milk. Therefore, vaccinations may start as early as eight weeks old and are then given every three to four weeks until the kitten reaches 16 weeks old, petMD says.
Kittenhood is the time when cat owners are the most conscientious about vaccines. "We see excellent compliance for kittens in their first year of life," notes Dr. Sara Sprowls, a veterinarian at Glenolden Animal Hospital in Glenolden, Pa. But compliance with the vaccine schedules "declines dramatically after that."
Responsible kitten owners must be sure to fully comply with the applicable vaccine regimens to ensure the health of their pets.
Core Vaccines for Cats
The American Association of Feline Practitioners (AAFP) divides vaccinations into "core" and "non-core" groups. Core vaccines are necessities for most cats and include:
Feline panleukopenia (FPV)
Also known as feline distemper, the vaccine is typically given in two doses, three to four weeks apart. Booster shots are given a year later and then no more than every three years thereafter.
Feline herpesvirus-1 (FHV-1)
This is administered at the same time and frequency as the FPV vaccine.
Feline calicivirus (FCV)
Also given at the same time as FPV and FHV-1 vaccines and boosters.
The rabies vaccine can be given to kittens as young as eight weeks old, depending on the product. Vets must follow state or municipal laws regarding the frequency of rabies boosters, which may be annually or every three years.
Non-Core Vaccines for Cats
The administration of non-core vaccines largely depend on the whether the kitten will go outside or not. Non-core vaccines for cats include:
The vaccine is typically given in two doses, three to four weeks apart. Booster shots are given a year later and then annually for at-risk cats. The AAFP highly recommends the FeLV vaccination for kittens.
There is a debate over the necessity of leukemia vaccinations for all kittens. "It used to be recommended only for outdoor kitties," Dr. Sprowls says. But it will also protect indoor cats in the event they get out, she adds.
The first dose is given as early as eight weeks with two more doses given at two- to three-week intervals. Annual booster shots follow for cats with a sustained risk of infection. This includes cats living outdoors and cat not infected with FIV that live with FIV-infected cats. The vaccine does not protect against all strains of FIV, however.
Other non-core vaccinations include Feline Infectious Peritonitis, Chlamydophila felis, and Bordetella bronchiseptica are recommended only for kittens that may be at risk.
Image: Mike White / via Flickr
An increase in the number of bad white blood cells
Featuring Gio
Except for the point coloration and blue eyes, the Himalayan is quite similar to the Persian. In fact, it is sometimes referred to as a "Colorpoint Persian." It derives its...


text:
LOVE'S BEEN ROUGH ON ME
Love's Been Rough on Me is a 1997 album by the Matriarch of R&B, Etta James. Her versatility and powerful voice bridged the gap between rhythm and blues and rock and roll. All the songs on the album sound fresh and she really can rock in these blues-influenced country songs.
Including insert
Her legendary 1997 album, available on vinyl for the first time
More ETTA JAMES
1. The Rock
2. Cry Like A Rainy Day
3. Love's Been Rough On Me
4. Love It Or Leave It Alone
5. Don't Touch Me
1. Hold Me
2. If I Had Any Pride Left At All
3. I Can Give You Everything
4. I've Been Lovin' You Too Long
5. Done In The Dark
Love's Been Rough on Me is a 1997 album by the Matriarch of R&B, Etta James. Her versatility and powerful voice bridged the gap between rhythm and blues and rock and roll. All the songs on the album sound fresh and she really can rock in these blues-influenced country songs. It just comes straight out of her heart when she's singing about pain and the things she regrets. It's one those wonderful examples of an album from an artist who has been active in the music scene for many years. The album shows Etta James at her best, still blending multiple styles to one effective sound.
Love's Been Rough on Me is available on vinyl for the first time.
THE EXCITING WILSON PICKETT
STILL BILL
GANDHARVA (THE CELESTIAL MUSICIAN)
ALL 'N ALL
LAST DAYS AND TIME
WINTER-HARVEST
WUDA CUDA SHUDA


Stress management refers to a wide spectrum of techniques and psychotherapies aimed at controlling a person's levels of stress, especially chronic stress, usually for the purpose of improving everyday functioning.
Stress produces numerous symptoms which vary according to persons, situations, and severity. These can include physical health decline as well asdepression. According to the St. Louis Psychologists and Counselling Information and Referral, the process of stress management is one of the keys to a happy and successful life in modern society. Although life provides numerous demands that can prove difficult to handle, stress management provides a number of ways to manage anxiety and maintain overall well-being.


and application of flame retardant fields.
SFIL is extra light and flame retardant insulation.
SFIL KOREA CO., LTD. are looking for the Joint Venture Partner who might be set up the production facility.
partition, builk head ship, insulating concret forms and panel.
In advance high technology to be collaborated for mutual environmental business further comming.


Like most of us in clay, my first studio was the classroom. (Thank you Laney College) When I finally got my very own kiln. (a big Scutt) I went wild for a time, making works that would fill up the firing space. Never mind that I didn't yet have the craft aspect under my control. I made some good-looking faulty pieces. They remain, my "special children" who can't go out into the world for fear of falling apart.
I can't emphasize enough the value of a slow bisque..especially for me because I use paperclay and slam things together in unorthodox ways. Alas, this wasn't fired by me, but I put her back together.
I can do that because it's paperclay) and I am crossing my fingers that she makes the final firing OK.
I has been a busy summer. I had two openings in the past week. Coastal Eddy in Laguna Beach was the first on Aug 3 and Last night was at the Main Street Gallery in Pomona. Unofficially, I was also part of a opening at Bistango (a very upscale restaurant in Irvine) Suddenly, I am all over LA like suntan lotion.
Last night the Clay and Glass show opened in Healdsburg. Lots of variety and some wonderful work all round. I delivered my pieces on Monday. After a bit of drama with my vehicle, I was late getting there, but they were very gracious and helpful. Did I mention the heat??? You could fry eggs on the sidewalk.
Since that day I have been resting and doing little day trips. I went up to Mendocino to visit (my ) gallery (William Zimmer) and to take in the breathlessly beautiful Mendocino coast. I'm reminded how much I love Northern California.


text:
#News Filter#
Stats and Analysis
© Shaun Botterill/Getty Images
Matteo Berrettini falls short of reaching his first Grand Slam quarter-final.
Berrettini Asks Federer How Much He Owes For Wimbledon Lesson
ATP Staff
This article contains:
Match Reaction
Italian reflects after 74-minute loss in the fourth round
World No. 20 Matteo Berrettini is getting his wallet out.
After Roger Federer punched a forehand volley into the open court to complete his straight-sets victory, the Swiss congratulated the Italian on a strong grass-court season, leading Berrettini to come back with a witty response.
"I said, 'Thanks for the tennis lesson, how much do I owe you?'"
Federer lost only 11 service points in the match, cruising to victory after 74 minutes on the back of 24 winners. The 37-year-old made just five unforced errors in the match.
You May Also Like: Federer Moves To The Verge Of 100th Wimbledon Match Win
"I think for sure I didn't play my best match, but he was just too good for me today. He was playing good and I was kind of tight, also," Berrettini said. "Before the match I was ready for that stuff, and also when he started to play like this, for me, it was really tough to do anything.
"You can try to change something, but when he's playing like this, it's tough to change. You can change mentally but he's not going to change anything. I think it's going to be really helpful for my career."
It took Federer 17 minutes to win the opening set, as he did a good job of blocking the Italian's 130-plus mph serves back into play to get to neutral in rallies. And it seemed like once the eight-time champion gained the momentum, there was little Berrettini could do.
More From Manic Monday
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Pella Goes From 'Wanting To Cry' To Outlasting Raonic
"I wasn't feeling so good about my strokes, my serve, my forehand, backhand, everything. I wasn't feeling so good, so I didn't expect that. I expected to be tight, to be maybe not ready, but not like this," Berrettini said. "I was saying to myself that it was normal. For me, it was [my] first time on Centre Court against him. It's normal.
"The points were going really fast. Just serve and first shot... I was just playing and trying, but like I said, it was too good."
More stories like this in:


In any particular occupation having the right tool can save you time, money, efforts and therefore a small part of your life will be used for something else instead of doing something you've already accomplished. So the right tools are very important – at least this is my opinion.
I'm creating websites with Mobirise Web Builder from almost half of year – got aware of the existence of the project somewhere around the version 2.0 something and it's my best website builder ever. I like the simple and intuitive way things get done in the Website Builder environment. I also like the idea of getting the creation of a website available to the masses so anybody needing a website could create a great looking one.
Nevertheless my deeper sympathy to the Mobirise Free Website Builder I've always known that there is no such thing as blocks predefined EXACTLY to match ANY vision – these can be developed only by a team of flying Unicorns. No matter how universal and flexible blocks get created there always is additional tweaking through some custom CSS or HTML or a minor compromises and changes to the initial design – that's just the way it is. If I am sometimes uncertain how something would look best – how can someone at a distant location create something fitting exactly my unclear at the time vision?
Anyway – in time I have faced multiple tasks with Mobirise Builder and completed them nevertheless the lack of an exact block in the side panel. And these exact quests have evolved me as a person and a professional each time I got something done. Instead of complaining about some functionality or content blocks missing I was always asking myself – What can be done to improve things? And the results of my quests I've tried sharing through these articles. The solutions were not perfect but somehow managed to fill (at least for me) the gap in functionality and appearance within the native Mobirise blocks.
Maybe this gap gave a chance of multiple Third party Mobirise themes which had variety of blocks but unfortunately often lacked sometimes even basic customization features or acted in unexpected way sometimes. Trying some of them I even experienced the emerging of a horizontal scroll bar into what was supposed to be a Bootstrap powered responsive website! So even though I found figuring out these underwater stones quite refreshing I got to a conclusion that I can't trust such theme enough to go for a real life project with it. I decided what I do with Mobirise would rest on native Mobirise team products I could rely and on the results of my own efforts.
Time and versions passed away until recently I got aware of the existence of the Additional Blocks Pack for Mobirise Builder which we are going to explore today. In its more than fifty blocks I found most of the things I was ever needing for my projects alongside with a great source of inspiration within some blocks I didn't think about so far.
The Additional Blocks Pack combines new functionality and fresh unexpected appearances with very well thought customization options and swift performance in Builder. Before starting this article I draw them all out in a test project and carefully observed for sharp edges as usually when I explore a new product. It was a very pleasant surprise to discover there merely were any. Today we're going to take a detailed look at all of them, discuss the possible uses and appearances which can be achieved and eventually some small improvements which will help us making them almost perfect. So, let's begin.
The Additional blocks are organized fallowing the same logic the Native Mobirise Themes do.
First you've got Intro blocks combining different functionalities – subscriptions and feedback forms, video popups, and content with clever styled images. The last update also introduced some new expression ways with the typed effects and animated backgrounds. We've also got an impressive Ken burns slider and contact intro combining images, icons, a contact forma and even a Google Map in one block so it gets fully functionally and content loaded.
Then the features blocks come to take place. Among them you'll find multiple segmented layouts allowing you to showcase topics or items of equal significance or outline the importance of some for example with the number in a row or with some expressive icons and images. The multiple different predefined layouts impress with well thought control panels and flexible options. There also are some of the significant Intro blocks tweaked for presenting a content – fully packed with sizing and padding options.
Further you'll find my personal favorites – progress bars, countdown blocks, accordions, toggles and tabbed content blocks arranged in multiple ways. These are entirely new types of blocks to the native Mobirise theme giving tons of interactive functionality and visual pleasure. Nevertheless they are bright new they are also quite well thought and flexible as we'll see further.
And the jewel of the crown – the content slider. A brilliant thought – arranging content carrying elements into a slider giving the user to select the number of the blocks being displayed at one slide. I love this block! It is being called testimonials block but the truth is just like the testimonials block from the native Mobirise3 it can be successfully used for practically any type of content.
Lastly there is the additional footer block which can be useful if you would like to add some kind of simple mini navigation at the end of your pages.
It is important to note that unlike the native Mobirise Mobile Web Builder themes almost all of the blocks in the Additional Blocks Pack Extension are unique – you won't find a copy of the same block with different switches on in the properties panel.
These are actually the first ones the user will see and should be chosen and styled carefully. It is proven that too crowded or unattractive intro can directly push the users away. The Blocks Pack got you covered – all the intro blocks are quite balanced offering expression and functionality sharing space on screen without messing up with each other. What is really good to see is the various implements of something so far seen in Mobirise only by third party theme developers – we now have intros with forms, intros with colorful icons allowing to present various essential features and even combinations – of appealing captions and text, features with icons and a form aside. And since it's a Mobirise development – they all resize flawlessly without any unexpected behavior we often see in the third parties.
The customization options are crafted to provide the designer comfort speed and almost full control of the appearance. It shows a lot of thinking has been done here. What should be mentioned regarding intro blocks and forms in particular is the useful Dark/Light appearance dropdown, the color picker for form background color when needed alongside with the good beloved options to of reversing the layout or freely selecting the background and its overlay and parallax effect.
There are also some fresh and inspiring implements like a centered image with a caption and some text and an overlay layer spreading to the middle of the image – almost like a border revealing the real world from the one of talks and descriptions.
Another fresh approach is the video popup leaving the space clean and tidy from the embedded video's black rectangle leaving the user to pick when and if to call it out. Another benefit from this is video starts in a light box automatically taking the entire space when needed saving those annoying "full screen" clicks and the restart of the video in order to see what's been missed while clicking on full screen.
Let's spend a minute talking about icons. A few versions now I enjoy watching the getting more and more both in number and quality. The icons extension really did grow to be some kind of a Swiss Army Knife offering an appropriate symbolic image for almost any occasion. And this comes in combination with flexible and well thought control panel allowing you to customize each element to the appropriate appearance. This way the thousands of icons sitting there come to be the perfect addition for the intro blocks and most importantly – with their help can be implemented almost any kind of appearance.
To amaze your clients and please the eye even more near the end of the intro blocks stack there are some blocks utilizing movement as an expression mean in fresh and appealing way. I'm talking about the Title with typed effect, animated background and the "Kenburns" and Parallax slider.
Think of kitten watching ping pong match. Fallowing rapidly moving / changing things is a reflex coming from the times people had to pay attention at such in order to live a bit longer. So what a better way attracting your user's attention of some large captions being typed and deleted and retyped again – works like a magnet for the eye. We also have the "Let's see what comes next" element – it's becoming like a micro story told in just three changing words. Or looking at it from the angle of Messaging Era – becomes like some kind of a conversation – you see what the other guy's typing and retyping trying to figure out which one fits best. Magnetic and powerful block.
There is a small pebble underwater here – utilizing this block you should take count of the length of the words you use and the size of the text itself. Selecting too long words might cause overflowing to a next line which scrolling down the site will result a jumpy appearance every time the long word in the block gets typed. This might confuse and even frighten the user – the first time I mentioned this effect was when preparing for this article. I had all blocks drawn out, the resulting site previewed and it happened this way I had to do something else aside from my laptop. So here I am discussing something and with my peripheral vision I spot something on my screen appearing and going back up. It was the bottom of a block being pushed down on screen but remember I was doing something else and just spotted something dark coming out of my dark navbar - so I thought somebody got in and messes out with my files! It was quite an emotional moment.
So to spare your users this kind of moments – select the changing words and the caption size carefully and it will all be just brilliant.
Now let's take a look at the far more subtle effect used by the animated text background block. You've got the good golden content showcasing layout consisting of a caption text and image but hey, what's going on here – there is some text moving in the background giving the feeling of depth almost like the main content and the image float in the air or over calm water. And of course the user stops to see what's gracefully passing underneath. The block has a speed setting for the text movement – you can make it move quicker but my advice is – don't – you'll spoil the grace. Let it flow slowly calming the user, stopping him or her to just observe for a while. Combine this with a short or medium in length strong positive message and your users will thank you.
A little pebble here too – nevertheless there are image and video options for the background of the block you would want to stick with the solid color for now and this is for two reasons - it looks much cleaner and appealing this way and until probably the next update setting background different than solid disables the scrolling text option. My thoughts on this – I love many foods but don't mix them all in one pot – the best way this expression mean works is with solid background and maybe the image and video background options should be omitted. On the other hand what if a subtle moving gif or video comes for a background – almost still but just almost – wow, this could work great! So my final opinion is – please make the scrolling text available with image and video backgrounds and let the designer's conscious lead them.
Remember those occasions when you're creating something functional and beautiful and it's almost ready, just almost and the need of sharing it to the world kind of twirls inside your stomach but hey, it's not ready yet should wait a bit longer. Or for example when you want to point the user's attention to a great upcoming event and try pointing out its significance? This is what the countdown intro blocks are just perfect for. In them I see an approach showing all over the Blocks Pack – combining multiple cool features into one peace and this way utilizing the space much more efficiently, giving the user better experience and the web designer – freedom and ease.
The Intro blocks with countdown provide few appearances in order to meet different occasions. We've got a classical Title/ Subtitle/ Countdown / Subscribe form appearance, followed by an impressing combination of resizable image (which is initially meant to be company logo but as well could be a product mock-up or one of the thousand predefined icons for example) animated caption utilizing the typing and retyping effect we talked about, of course – some meaningful content, clean and subtle countdown block and a very pleasant way to display a subscribe form – with a single button sliding aside on hover revealing the subscribe form field. This collapsed form actually suits my taste quite a bit since nevertheless the subtle styling forms have always been taking too much of the space out there and let's face it – most of the times have been just passed away. This have always seemed like an awful waste of space and bother for the eye to me – an issue this approach totally solves.
So far we've discussed Intro blocks focused on the content with appealing images on the background mostly a bit dimmed from the overlay layer in order to obtain legibility for the content. The next intro block we're going to talk about utilizes the images and the effects applied to them as a standalone expression means – you've probably guessed it – it's the Ken burns & parallax slider. The subtle movement of the images adds the feeling of depth – it's almost like they really move out there through the window. In addition you've got the well-known content areas as Heading, body and buttons to insert some content along the beauty moving out there.
And finally from the segment of Intro blocks there are the outstanding blocks with a map and a contact form. To utilize the space most efficiently there also are some short content areas spiced with icons but due to the well thought Block Properties this is purely optional and again we have the choice for subtle or classical forms appearance.
When you want to do business in 2016, you need a web presence. More people do online research on a business than sometimes even word of mouth. Not everyone, however, is skilled at the coding, writing or general design of putting together a website. Is this an excuse to not be a part of the search process your customers, friends or the world in general uses? For those people, one option is Weebly. And, no there won't be any references to wobbling (and you know how old you are if you get the reference). An advantage that Weebly promotes is free website design. It's reported that they have over 12 million users that both professionally and personally use Weebly for designing sites for a variety of reasons for both the fact that you can build a website easily but also cheaply, or free!
If you know CSS, the coding language for building websites, you probably either aren't interested in using this or you're being lazy. The rest of us have some options and there are a wide variety of options for putting together webpage using the over 100 templates provided and you can customize these with their Build Editor that allows you to drag and drop these modules onto your page and it happens on your browser, in actual real time so you can see the results immediately and change things that you like or don't like. Because you don't have install anything onto your computer, even if you don't own a computer or if you're out in public at a library for example, you can build or update your contribution to the Internet without having IT skills of a college graduate or the typical genius kid down the block from you. Another benefit to Weebly is their assistance for web design in the form of the Site Planner. Yes, you could just randomly drag and drop the elements like text and video blocks onto your page but besides it not really looking all that aesthetic, perhaps it would have a better flow for visitors dropping in for the first or fortieth time. The Site Planner will work with you, based on how little or much help you want, to put together a page that will reflect your goals. This feature also helps you customize your text for Search Engine Optimization that works with major search engines and not get you red flagged for abuse.
Another major factor with our on the go society is a website that not only looks good on your home computer with the thirty inch monitor but on your mobile device. Weebly best free website builder works with the user to ensure that the site seen on a home laptop will be the same seen on a table or phone.
A nice bonus is that advertising isn't a forced issue. Typically, free websites have to pay the bills somehow and they tell you upfront, or you find out, that ads will be inserted as a trade-off. Weebly promises users that they can use their own ads, work with Google or have nothing without concerns of being surprised by ads for products or services the designer may be opposed to.
The prices aren't quite easy to find (you typically have to sign up for a free account) but you have the option of a Free, Starter, Pro and Business Accounts with prices of $3.29, $6.63 and $19.54 respectively for a monthly cost with support naturally increasing with the higher levels.
Is it worth it? You get quite a few perks for free with the aforementioned bonus of no forced advertising. If you know CSS then you obviously get more from it and of course if you're a paying customer you'll get more support and options but for someone who wants or needs an online presence, Weebly responsive menu gives you great features and a builder assistant that will help you put a great website together for your personal or business needs.


Twitter Charts... Stock Market Analysis You Can Use!
elcome to Twitter Charts... stock market analysis free for you!
"More Sideways Movement For S&P 500?"
"Illumina Inc. Grows Profits In Spite Of Market Sell-Off!"
"Oceaneering International Inc. Continues Meteoric Rise To Fresh 4-Year High!"
"Chesapeake Energy Corporation Meets Tough Elliott Wave Resistance"
"Energy Service Stocks Continue To Surge"
"Automotive Stocks Rev-Up In The New Year!"
"S&P 500 Prints Conflicting Patterns"
"Staples Slides On Retail Weakness!"
"THS Strong In Sluggish Market"
"Energy Service Sector Leads Market Lower"
"Market Hedgers Pile Into Gold!"
"Just How Bad Is This Recession?"
"Is This Rising STAR In Your Portfolio?"
"Bull In The Bear... Is The End Near?"
"All That Glitters Is Gold!"
"More Bank For Your Buck?"
"Who Benefits Under Chrysler Bankruptcy?"
"World Economy Begins Recovery? More Markets See Less Red."
Do you have a stock selection technique, method or example? Share it!
Your method or technique will appear on a Web page exactly the way you enter it here. You can wrap a word in square brackets to make it appear bold. For example [my method] would show as my method on the Web page containing your stock picking method.


When you're designing digital media projects, how you display your text is just as important as what it ultimately says. Using the wrong typography can alter your message dramatically, no matter what the words are saying. Make sure you're communicating clearly by giving your font selection thorough consideration. The right picks will make your finished piece compelling, eye-catching, and thoroughly engaging so you can leave your audience with the perfect impression.
As you're choosing typography, one of the first questions you'll find yourself facing is whether you want to go with a serif or sans serif font. If you're not familiar with these terms, serif fonts are those with little lines attached to the letters. Some people describe them as having "feet." These tiny embellishments are known as serifs. Sans serif fonts are those without these embellishments.
Times New Roman is a classic serif font. Some people believe that serif fonts are easier to read and recommend them for any large block of text. Sans serif fonts, then, are more commonly used for headings or shorter blocks of text. Sans serif fonts, such as Calibri, are also better for captions or other bits of small text. The lack of embellishments makes them easier to read in fine print.
While you should give some consideration to your choice of a serif or sans serif font, know there are no hard and fast rules. You'll find plenty of readable web pages with long blocks of sans serif text, which prove that either option is ultimately fine.
Display fonts are decorative fonts that have a playful twist. The fanciful typography used for many brand logos would be considered display fonts. Display fonts can be more difficult to read in a large block of text. However, they're ideal for headings or even subheadings. If you're creating an infographic or video, a display font is a good way to grab your viewer's attention. It also adds some personality to the piece as you highlight the title or an important heading.
If you're looking for a display font to use for the branded logo in your digital media design, you may want to consider investing in a more exclusive paid font. While there's a wealth of free fonts available online, choosing something that's widely available to the public can dilute your brand image. Paid fonts also tend to be higher in quality than your average free display font.
The weight of a font is essentially how thick it is. When you're considering weight for your typography, you need to balance it carefully with the graphics in your piece. Opposites attract in this area, and the right pairing will give you a stunning presentation. Offset a thick-lined heavy graphic with a lightweight font that has thin lines. If you're using a graphic with fine lines, a heavier font will accent the imagery nicely.
You should also alter the weight for headings versus body text or captions. While the more traditional approach is to use heavier typography for headings and a lighter font for the body, you can reverse this as well. Simply make sure you're distinguishing between heading levels in your design, particularly when you're using the same font for multiple purposes.
Readability is one of your prime concerns when you're choosing typography for digital media. If you're placing text over video, your viewers will have a limited amount of time to absorb what's written. In these instances, use the cleanest simplest font possible. The more text you have in a block, the simpler your font should be.
You can indulge in more decorative display fonts for headings, subheadings, or even a few highlighted words and phrases in an infographic or other graphic design. However, you should make sure even your most heavily embellished fonts are easy to read. Have a few sets of eyes look over your lettering to make sure there are no unintentional miscommunications because of a difficult typography pick.
Some believe typography has an emotional impact on the reader. There are some widely accepted associations that typically apply to particular types of font. Scripts are usually perceived as feminine, intimate, and earnest. Slick and modern sans serif fonts feel trendy. Bubbly fonts are playful and often childlike. Most serif fonts have a feeling of traditionalism and stability.
Highly stylized fonts can carry a broad range of emotions depending on their design. Fonts reminiscent of any highly recognizable brand will evoke many of the emotions associated with that company. This can be either positive or negative and will vary greatly depending on the audience you're targeting. If you're working with a highly decorative font, take time to consider the emotional associations that will accompany it. Make sure these are in line with your brand message.
Playing with typography is quite addictive once you dip your toe into the vast waters of decorative and design-driven options. Though you may fall in love with a dozen different fonts, it's important that you choose just two or three for your digital media project. Playing with an overabundance of fonts will leave your finished piece looking cluttered and confusing.
Make sure the fonts that you select look good not only independently but together as well. They don't need to match exactly, but they should complement each other. Bubbly childish typography will look out of place next to an elegant script. If you opt for a design font, pair it with a simpler classic for body text. Keep modern fonts together with other sleek modern options, and pair classic typography with similarly traditional picks. A simple yet eye-catching typography palette will keep your entire piece looking clean.
Give your typography careful consideration as you're building your digital media design. Test various fonts with different color combinations, graphic styles, and placement. Even a minor adjustment in orientation can have a major impact on an infographic. The right typography will make it all click and give you a flawless piece that's sure to resonate with your audience.


text:
Q: ¿Cómo obtener valor especifico de un Json Array en SqlServer? ¿Cómo puedo recorrer el objeto y obtener los valores específicos del json?
Este es el formato:
[{"NumberId":"123456789-0","CompanyName":"Team Leader","IdKey":"1867","Industry":"Home Supplies, Garden & Construction Materials"},
 {"NumberId":"123456789-0","CompanyName":"Team Leader","IdKey":"301782","Industry":"Business and Professional Services, Distribution lists"},
 {"NumberId":"123456789-0","CompanyName":"Team Leader","IdKey":"1875","Industry":"Indumentaria, Textiles y Accesorios"}]

Estoy usando este código, pero no me establece los valores en la variable @CompanyName (Me devuelve null).
 DECLARE @itemsJson VARCHAR(MAX) = (SELECT NumberId, CompanyName,[Key] AS IdKey, [Value] AS Industry FROM CompanyProfile  CROSS APPLY OpenJson(IndustryMainSector) WITH ([Key] varchar(10), [Value] varchar(1000)) FOR JSON AUTO);
              DECLARE @index INT = 0;
                          DECLARE @Cçcontador INT = 3;
              SELECT @itemsJson
              DECLARE @companyName VARCHAR(200);

              WHILE(@index < @contador)
                 BEGIN

                     SET @id = @index + 1 ;
                     SET @companyName = CONCAT('$.CompanyName[', @index ,']');
                     SET @companyName = (JSON_VALUE(@itemsJson, @companyName));
                     SELECT @companyname
                     SET @index = @index + 1;

                 END

A: El problema es que tienes el índice en el lugar incorrecto.
SET @companyName = CONCAT('$[', @index ,'].CompanyName');

También podrías tener todo en un solo resultado usando una tabla de números.
 DECLARE @itemsJson VARCHAR(MAX) = '[{"NumberId":"123456789-0","CompanyName":"Team Leader","IdKey":"1867","Industry":"Home Supplies, Garden & Construction Materials"},
 {"NumberId":"123456789-0","CompanyName":"Team Leader","IdKey":"301782","Industry":"Business and Professional Services, Distribution lists"},
 {"NumberId":"123456789-0","CompanyName":"Team Leader","IdKey":"1875","Industry":"Indumentaria, Textiles y Accesorios"}]';

WITH
E(n) AS(
    SELECT n FROM (VALUES(0),(0),(0),(0),(0),(0),(0),(0),(0),(0))E(n)
),
E2(n) AS(
    SELECT a.n FROM E a, E b
),
E4(n) AS(
    SELECT a.n FROM E2 a, E2 b
),
cteTally(n) AS(
    SELECT ROW_NUMBER() OVER(ORDER BY (SELECT NULL)) - 1 n
    FROM E4
)
SELECT JSON_VALUE(@itemsJson, cp.companyPath)
FROM cteTally
CROSS APPLY( SELECT CONCAT('$[', n ,'].CompanyName') AS companyPath) cp
WHERE n < 3;

redpajama_set_name: RedPajamaStackExchange