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xfn-brainstorming
xfn-brainstorming /
Revision as of 09:34, 8 July 2007 by Tantek (talk | contribs) (added fan/follower example sites, add thoughts on mentor vs mentee)
XFN Brainstorming
This page is for brainstorming about various uses and details of XFN - The XHTML Friends Network, as well as collecting input for potential extensions.
1 XFN Brainstorming
1.1 Required Reading
1.2 Contributors
1.3 Extending family relationships
1.4 Simple Groups and Members
1.5 Fans and followers
1.6 Mentors and Mentees
Before participating in any XFN brainstorming please read and understand the following:
XFN intro
XFN background
XFN FAQ
XFN and other services
Tantek Çelik
CiaranMc
Extending family relationships
The XFN: Background page says:
We considered adding "grandparent," but in the end dropped the term because it seemed unlikely to be used in the near future. It may appear in future versions of XFN.
Presumably the assumption is that a grandparent won't have a website, but:
I think it's important in some situations to capture the age difference in a relationship in a way that @rel="kin" doesn't seem to.
Even if they don't maintain it themselves (or are deceased) there might be a URL that does a good job of representing a person.
Consider a site about one's family tree. It might have something like:
I can trace my family back to
<a href="http://en.wikipedia.org/wiki/William_I_of_England/">
William the conqueror.
In these cases it would be useful to have @rel="ancestor", and perhaps a corresponding @rel="descendant". -CiaranMc
Simple Groups and Members
A very simple extension to XFN could enable decentralized group membership. E.g.
rel="group". A person could link from their page to the page of a group that they belong to (e.g. their company, school, DJ collective etc.) and thus assert that they belong to that group.
rel="member". The web pages of groups could link to who they consider members and thus assert that person's membership.
The relationships could be required bi-directional in order to confirm group membership, that is, both the individual must link to the group with rel="group" and the group must link to the individiual with rel="member" in order for the membership to be considered "true".
See also Group Brainstorming.
-Tantek
Fans and followers
It's becoming a common aspect of many social networks that you have unreciprocated and non-friend-based connections to people. These connections are particularly noteworthy where you don't really ever expect to have your connections reciprocated, but instead are similar to the idea of "rel-muse".
I would propose adding "rel-fan" or "rel-follower" to the collection of XFN values -- as being something like a "contact" or a "muse" but having a different purpose within the realm of social networking. Again, given that this is showing up in social networks like Pownce (fan), Twitter (follower), and that these words are becoming common, I wonder if it wouldn't make sense to even ditch rel-muse in favor of rel-follower and rel-fan (the former implying some kind of positive social stalking and the latter a kind of amiable appreciation for someone's work).
This fan/follower designation seems sorely lacking from Flickr where everyone falls into either contact, friend or family... but in many cases, you just like someone's photos and want to be able to check in on them every now and again, similar to the way that people "follow" or "subscribe" to blog feeds... Someone who reads my blog feed could be considered a "follower" -- as in, "someone who follows my blog".
- Chris Messina
Examples (sites that have the concept of "fan" or "follower")
http://twitter.com/ (has followers vs friends)
http://upcoming.org/ (has fans vs friends)
http://pownce.com/ (has fans vs friends)
Tantek 02:34, 8 Jul 2007 (PDT)
Mentors and Mentees
Though seemingly rare, I personally have found use for rel="mentor" and inverse rel="mentee" (see wiktionary definitions: mentor, mentee). I don't have sufficient evidence to even consider proposing adding these to XFN, but I wanted to capture them here as a brainstorm while I look into using them personally and research examples in the wild.
XFN - The XHTML Friends Network
hCard
hCard brainstorming
Retrieved from "http://microformats.org/wiki/index.php?title=xfn-brainstorming&oldid=18212"


This 70th anniversary of the end of WWll brings together veterans of the war who fought in the military of the former Soviet Union including military and civilian survivors of the siege of Leningrad.
Helping to support the occasion will be RACH-C, represented by its president Olga Zatsepina, the Princess Diana Bagrationi Foundation, represented by its founder.
The highlight of the ceremony will be the presentation of special medals commissioned by the government of the Russian Federation presented by the Consulate General in NY.


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Home » 2015 Food Safety Summit encourages discussion with government officials
2015 Food Safety Summit encourages discussion with government officials
Event adds session about foodborne disease outbreaks
KEYWORDS Food Safety Summit / HACCP / USDA
The 2015 Food Safety Summit, which will take place April 28-30 in Baltimore, will continue its goal of "Providing Solutions for Today and Planning for Tomorrow" with focused sessions on the Food Safety Modernization Act (FSMA) updates, a full-day forum on integrating the nation's food safety system, a session on the 2014 foodborne outbreak and much more.
Right before the conference, show host BNP Media, the Troy, Mich.-based parent company of Beverage Industry, will offer pre-conference Hazard Analysis Critical Control Points (HACCP) and Seafood HACCP training on April 27. To kick off the event on April 28, The Association of Food and Drug Officials will present a full-day information-sharing forum to provide updates on the many efforts and projects in place to integrate the nation's food safety resources.
On April 29, Food Safety Summit will host its Keynote Session, featuring a panel of experts, including Donnie Temperley, vice president of operations at Hormel Foods; Keith Carango, senior vice president and chief operating officer of The Cheesecake Factory; and Charlean Gmunder, former vice president of manufacturing at Chiquita Brands, moderated by Will Daniels, former senior vice president of operations at Earthbound Farms.
On April 30, attendees can sit in on an open conversation with government officials from the U.S. Food and Drug Administration, U.S. Department of Agriculture, Association of Food and Drug Officials and Centers for Disease Control and Prevention.
In addition to these events, 2015 Food Safety Summit attendees will have the opportunity to experience the exhibit hall; a Hot Topics general session; workshops covering topics such as allergen and temperature controls, reducing risks, finance, consumer food safety education, traceability and transparency, foreign supplier verification, and social media; and a special session inspired by the foodborne disease outbreak at the 2014 Food Safety Summit that will look at outbreak investigations and preventing future outbreaks.
To learn more about or register for the 2015 Food Safety Summit, visit foodsafetysummit.com.
Food Safety Summit educates on food safety progress, certifies professionals
PepsiCo director of food safety to speak at Food Safety Summit
2017 Food Safety Summit expands
Food Safety Summit 2014 to focus on regulation
Beverage Quality and Safety
Big Food: Critical perspectives on the global growth of the food and beverage industry
Strategic Questions in Food and Beverage Management
Food and Beverage Cost Control, 7th Edition
Government Liaison Services Inc.

redpajama_set_name: RedPajamaCommonCrawl


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Joseph Polli Named AAPS President-Elect
Pharmaceutical scientist association announces upcoming term's board of directors.
Joseph W. Polli from GlaxoSmithKline has been elected to serve as president-elect of the American Association of Pharmaceutical Scientists (AAPS) and will begin a three-year term on the AAPS Board of Directors (as president-elect, president, and immediate past president) in November 2018 at the AAPS PharmSci 360 meeting in Washington, DC.
"My focus as president-elect will be to ensure that decisions from the AAPS Board of Directors drives member value, delivers the ongoing transformation of the association, and maintains the current fiscal stewardship, with a vision that AAPS will be prepared to serve and advance the capacity of the next generation of pharmaceutical scientists. It would be an honor to serve as the 2018–2019 president-elect," Polli noted in his election bulletin.
AAPS also announced that Douglas H. Sweet, Virginia Commonwealth University, was elected as a member-at-large and Mark J. Rose, CHDI Management, Inc. was elected to serve as treasurer.
Other members on the 2019 AAPS Board of Directors are Members-at-Large Reina Bendayan, University of Toronto; Allen C. Templeton, Merck & Co., Inc; Annette Bak, AstraZeneca; Bernd W. Meibohm, the University of Tennessee Health Science Center; and President Dale E. Wurster and Past President Christopher R. McCurdy.
Source: AAPS
OutsourcingBioBusinessManufacturingSupplier NewsManufacturing, BiologicsManufacturing, Drug ProductsContract Manufacturing, Finished Drug Product


The McCain Great Village Raffle is on and your empty packet of McCain Chips have never been so valuable. Pick up a promotional pack in stores and pop the code inside the pack into the form on the web site linked for your chance to win 1 of 28,515 Freebies worth �3 Million.
10,000 x opportunities to Adopt a Piglet.
Just head over to the McCain Great Village Raffle web site to enter your codes from your promotional packs.


"When I was young, which is like a million years ago, I made up my mind I was going to help people. You don't think for yourself when you have a large family. I've always been more interested in other people than myself and it seems like, when you are a nurse, they think that's what you should do – take care of everybody that comes along. So I did. There was always somebody to take care of. But then when I arrived to my own old age they were all gone. It's hard to lose all your family and friends. You'll see what I mean when you get to be an old lady.
I have lots of regrets. I don't think I did much for myself. I didn't accomplish very much with my life. I had lots of opportunities. I had a chance to have a job as a nurse traveling all over the world and I turned it down because I had to take care of my mom and dad. But most of the things you plan don't come true. At least it didn't for me.
When you are young you think everything should go your way I think… go to a dance and dance all night and all that stuff - and you think that's part of your life. But then, it doesn't last for long. It's not a forever thing. You have a different opinion of things as you get older.
Mostly if you want to write a thick book you could write about what I didn't do that I should have done but I didn't do it, no matter what it was. You know I drew a horse when I was in high school and I never could put a tail on it. I think it is still wondering around the family somewhere with this horse with no tail. And I couldn't do it. I tried and tried. I traced them and tried all different tails but it never came out right. Maybe he was born to be without a tail. I don't know."
Ena and I met at Vintage Golden Gate in San Francisco where she had been living for a number of years. Ena was always beautiful for our meetings – her hair was done, her nails painted and her jewelry pinned upon her ears and sweater. Ena is the kind of person who calls you "sweetie" and "darling" and makes you feel as though you have always known her. A nurse, Ena was a natural born caretaker; but reflecting back, she realizes that she never made the time and space to follow her own dreams. She was full of regret that she did not take the opportunities that she believed would have made her life more fulfilling and exciting. Even though we met several times, she could never understand why a young person like me wanted to interview her for this project. Ena died on February 20, 2016.


The manual can be downloaded to the computer in a PDF version that includes bookmarks, making it easy to study and orientation of the manual. To download the Hebrew version click here.
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Solano County, CA
Infected: sometime before 2011, details unknown
Diagnosed: 2014
Current health: deceased
I believe Andrew was killed by Lyme because our current medical and psychological system is happy to treat symptoms and never find the root cause of illness. –Scott G. (Andrew's Dad)
Unfortunately, Lyme disease is a very challenging illness. Far too many patients struggle for years with debilitating symptoms that are dismissed or misunderstood and frequently misdiagnosed. Below follows an emotional story shared by the father of a recently deceased Lyme patient, who struggled for years to be successfully diagnosed with Lyme.
"The story of my son Andrew Greer does not have a happy ending. Andrew was an amazing, one-of-a-kind person. He deeply cared for people. He was extremely athletic and bright and kind. People who met Andrew even briefly came away knowing they had met someone who was special, who listened and cared. People who knew Andrew well knew that this perception was no illusion. Andrew loved his three brothers and his parents deeply. He loved adventure — surfing in Bali, trekking in Nepal and in the Sierras, traveling to Argentina …
"Andrew's odyssey with Lyme began in 2010. He began having pain in his hips and went to a Doctor who said he would need hip surgery. Andrew decided against the surgery and opted to treat with physical therapy and nutrition. Two of his passions. The pain turned into crushing fatigue. Andrew used to workout like he was training for the NFL. Now, he was so fatigued he could barely move and his brilliant mind became foggy.
"He went to a Doctor who told him he had adrenal fatigue, and was put on a special diet and supplements. This condition turned into a feeling that his connective tissues were compromised, so he changed doctors and new blood tests were ordered. These tests showed evidence of parasites. He also began to see a psychiatrist for anxiety and depression. Andrew began having severe environmental sensitivities — so bad that he couldn't live indoors. He moved to Kauai and worked on an organic farm to try to heal. After returning from Hawaii, he finally found a doctor who was able to determine he was suffering from Lyme. By now Andrew was very suspicious of Doctors and he opted to only be treated with natural medicine.
"Last summer, the Lyme began to affect his mind in such a way that he felt that by eating he was harming people. He began to lose weight drastically. After unsuccessfully trying to get him into a Lyme-literate psychiatrist or psychologist we took him to the Stanford ER. When I told the ER doc that Andrew was suffering from chronic Lyme, the doctor said he didn't believe in chronic Lyme. Andrew ended up in the Psych unit at Stanford where he was given psych meds, and tested for number of things. They reluctantly tested him for Lyme even though I had given them the positive test results from his Lyme doctor. The test Stanford used came back negative which is not uncommon, so they just treated him for his psychological symptoms.
"Seeing that we were not going to get any help with his Lyme from Stanford, we pursued a more aggressive treatment from the doctor who had originally found he had Lyme. I think by this time Andrew was pretty sure he was never going to regain his old self and decided to end his life. He agonized over this decision for months and 2 days after Christmas he left this world.
"I believe Andrew was killed by Lyme because our current medical and psychological system is happy to treat symptoms and never find the root cause of illness. My hope is that organizations like Bay Area Lyme and ILADS are able to raise awareness and money to develop accurate tests and treatment for this terrible disease."
2 Comments on "Andrew G."
Trysten Walters says:
I am praying for your son. He's with the angels. I'm so incredibly sorry for your loss. I'm currently fighting Lyme undiagnosed and want to end my life every day because no one will listen to me. Your son was so strong and fought an almost impossible battle. That's beautiful. His story it's comfort and helps so many people. Thank you for sharing. God bless you.
So sorry for your losss and I feel you are right. It is a difficult disease to fight and you are 100% right about just treating symptoms instead of finding the cause. We got lucky to finally find a Lyme literate doctor, but went through the same things you are talking about before we found him. Most doctors here don't even believe in it, but the veterinarians will treat immediately. Hopefully this will change sooner rather than later. Until then, we will have to keep it in front of people.
Read More Lyme Stories
All Lyme Disease Stories
We're making Lyme disease easy to diagnose and simple to cure. Join us in finding a solution.


Meaning and definitions of labyrinthine, translation in Gujarati language for labyrinthine with similar and opposite words. Also find spoken pronunciation of labyrinthine in Gujarati and in English language.
What labyrinthine means in Gujarati, labyrinthine meaning in Gujarati, labyrinthine definition, examples and pronunciation of labyrinthine in Gujarati language.


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Exhibition Tour and Studio Visit: Sheffield
North Member Programme, Tours, Trip
S1 Artspace
120 Trafalgar Street
Sheffield, S1 4JT
Join us for a series of exclusive events in Sheffield. The day will include:
• A tour of Bloomberg New Contemporaries 2011 led by Director Rebecca Heald and Chair Sacha Craddock.
Established in 1949, this annual exhibition showcases the best work from artists still at, or just graduated from, art schools across the UK. The 40 participating artists have been selected by a panel including artists Pablo Bronstein, Sarah Jones and Michael Raedecker. This is the first time the show has visited Sheffield in over 20 years.
• A studio visit with artist Haroon Mirza. In his assemblages and sculptural installations made from furniture, household electronics, found video footage and existing artworks, Mirza explores the possibility of the visual and acoustic as one singular aesthetic form. Mirza won the Northern Art Prize in 2010, and was selected for the British Art Show 7 and awarded the Silver Lion as the most promising young artists at the Venice Biennale 2011.
• A behind-the-scenes visit to the 'works on paper' store for The Graves Gallery. Louisa Briggs, Senior Curator of Visual Art, will show a selection of key works, some of which have been acquired with the support of the Contemporary Art Society.
• And finally, a special buffet dinner hosted by Bloomberg New Contemporaries at Sheffield Cathedral.
This event is part of a series of events programmed by the Contemporary Art Society in the North East. Membership cost is £25 for New Members. This is the 3rd year of the pilot programme and we are currently offering programming until July 2012.
If you are not yet a member and would like to join, or to receive further information about the organisation and its activities, please contact Mark Doyle at mark@contemporaryartsociety.org or call 07891 880 498.


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BITS is a new generation Institute and a rare creation of MPCT in a new ripple of educational feats and excellence in India and abroad. In its chain of achievements, the Trust has started two Polytechnics one at Sarsa-Ghogra, Bhiwani, another at Paluwas (Maham Road), Bhiwani, B.Ed. College for Women in the year 2006 at Paluwas (Maham Road), Bhiwani. BITS International School, Bhiwani has also been started by the trust recently. Further, it plans to add new feathers of BITS Dental College and BITS College of Pharmacy, Bhiwani to impart Medical and Pharmacy at their door-step.
ITS located about 80 kms. from Delhi Boarder, 34 Kms. from Rohtak and 10 Kms from Bhiwani on Bhiwani-Rohtak main highway. The campus has been developed in an area of 100 acres in the scenic surrounding with well-developed computer centers, workshop, laboratories, classrooms, library, hostels, captive, power generator, playground banking and medical and telephonic facilities etc. all effort are being made to keep the students in good health and confort in an atmosphere chongenial to studies.


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History of Believers New Life Ministries
Pastor Ted Williams was sent by God, from Silsbee, Texas, to shepherd over a flock at Call Community Center C.O.G.I.C. in Call, Texas. Through seeking God's face for guidance to teach his people, He began to receive revelation knowledge about God's word. While praying and meditating this new found knowledge, Pastor Williams received the mandate from God to preach and teach the revealed word boldly and uncompromisingly. Knowing he would encounter opposition, because of the traditional and denominational mindsets of the people, Pastor Williams was hesitant to make the transition in his ministry method. But after much prayer and deliberation, He took the step of faith and began teaching the Word of Faith with revelation.
Consequently, with the change came much persecution. The word of faith was not readily accepted by the church congregation, because it was perceived as being new and different from the traditional and customary church doctrine. Despite the resistance, Pastor Williams continued to teach the word of faith.
On February 16, 2001, God spoke to Pastor Williams and instructed him to write a letter of resignation to Call Community Center C.O.G.I.C. It was decided that He could have his last service at Call Community Center on Sunday, February 18. This day had previously been proclaimed as a supernatural day, and indeed it was. There was a morning service at 9:30 am and an evening service at 6:00 p.m. As the congregation gathered for the services, the anointing was thick and the power of God was present. People from the surrounding areas came and were delivered, healed and set free.
Determined to follow God's mandate for his life, Pastor Williams pursued the vision of establishing a Word of Faith ministry. As a result, on February 20, 2001 Believers New Life Ministries Church International was established with approximately 40 members at its current location on Hwy 96, N in Kirbyville, TX where we are Growing People Every day!


Hiring? Toptal handpicks top digital project managers to suit your needs.
According to IDG's State of Digital Business Transformation, 89% of organizations adopted or have plans to adopt a digital-first strategy in 2018. The key technologies driving digital transformations in companies are big data/analytics, mobile, cloud, and APIs/embeddables.
More and more non-IT companies are restructuring their products and services around digital capabilities brought on by new technologies. Companies have to undergo a cultural shift and adapt Agile workflows to thrive in the new digital reality. Moreover, a digital transformation requires a lot of tactical level decision making in a constantly changing market. Project managers are some of the most important people in the organization for a successful digital transformation.
If at some point in the last five years you have been going through project manager job listings, you might have seen the role of a digital transformation PM. A lot of companies have digital transformation strategies and the term "digital transformation" is used in a lot of different situations, sometimes even being used interchangeably with "digitization" or "cloudification." Let's unpack this term to see what the different meanings behind it are.
20-30 years ago, digital transformation was essentially digitizing analog processes within companies. During that time, computers were becoming a mainstream tool to carry out work in the office. This meant that opportunities arose to make efficiency gains in many areas like internal communication, data storage, contract management, etc.
This form of digital transformation is still relevant today as technologies are constantly improving, and we see improvements being made even in digital-first companies like teams moving from email-based communication to tools like Slack or collaborative document editing with Google Docs. However, in today's terms, this is a narrow understanding of the term digital transformation, in which the synonyms like "digitization" and "cloudification" make sense.
For the rest of this article, when we talk about digital transformation, we will refer to the description in this section.
Redesigning the sales channels according to online user behavior.
Introducing software development to enhance existing products or services.
Capturing and utilizing data to create internal or customer-facing analytics.
Digital transformation presupposes the introduction of Agile practices. Becoming digital both allows and requires a company to be more responsive to customer needs, more proactive in gathering client feedback, and more adaptive to changing market conditions. Some companies provide very good examples of how they have restructured their businesses around digital capabilities in their markets.
Domino's is an American pizza restaurant chain, founded in 1960, with franchises in more than 85 countries. In the 2000s, the company was not doing too great as its stock hit an all-time low in 2008 at around $3. Around that time, the company started its digital transformation journey and identified itself as an "eCommerce company that happens to sell pizza" according to Kelly Garcia, Domino's SVP of eCommerce Development and Emerging Technologies.
Domino's adopted a mobile-first strategy and relied heavily on A/B testing to both drive digital product development and cut down costs at the franchise level. Most recently, they introduced a new platform called Domino's Anyware, which allows customers to order food not only on their mobile apps but also via SMS, Twitter, messaging platforms, smart speakers, and other means of communication.
Domino's was successful in its digital transformation and its stock price reflects that—in the period between 2010-2018, it has grown more than 3000% and has outpaced such juggernauts as Google, Amazon, and Apple. According to Kely Garcia, the company is currently looking at voice interfaces and conversational eCommerce to fuel their next period of growth.
John Deere was founded in 1837 and started off as a general repair shop and a manufacturer of agricultural tools such as shovels and pitchforks. It is now mostly associated with their tractors and other agricultural machinery, but the company has experienced an even more profound digital transformation than Domino's.
During the last several years, John Deere started transforming itself into a data company. That doesn't mean that they will stop producing tractors, but that their mid to long-term competitive advantage lies with providing data-enhanced capabilities to their customers. John Deere achieves this in two ways.
Firstly, the manufacturer is enhancing its machinery capabilities by using sensor and IoT technologies to deliver precision farming. By acquiring machine learning companies like Blue River Technology, John Deere can use computer vision and AI to distinguish between different plant growth stages, recognize weeds, and apply fertilizers and chemicals only when they are needed.
Secondly, all of their machines generate troves of data, which is synced to the cloud every 5 seconds. All of this data plugs into John Deere's Operations Center. The company has taken a platform view and opened the Operations Center to third parties, from small AgTech startups to large companies like DuPont.
All of these changes required John Deere to introduce Agile processes and to hire software developers and data scientists. The company has even opened an office in Silicon Valley. Most importantly, the people producing the machines have to work in tandem with the new technology units. "We work hand in hand. They know their machine and the job it does, we know the tech, and together we build this integration," according to Than Hartsock, Director for John Deere Precision Agriculture Solutions.
One might get the impression that digital transformation is something that happens at the board or executive levels with no substantial decision power for other people in the organization. That could not be further from the truth—project managers in particular play a vital role during a digital transformation.
Anand Swaminathan, a senior partner at McKinsey, describes the difference between a technology transformation versus a digital transformation and why PMs are relevant in the latter. If a company decides to introduce an enterprise resource planning (ERP) system for financial operations, that does not entail a fundamental change in how the company operates and how it interacts with clients. This is an example of a technological transformation, where the senior executives make the main decision and the rest of the affected employees have to adapt to a new reality.
In a digital transformation, top management outlines the vision (e.g., eCommerce company that happens to sell pizza) but the implementation of it lies with the "executive muscle" of the organization—that is, the project managers. As Swaminathan puts it: "You are now designing a fundamentally new set of experiences, products, and services for your customers." That puts a lot of power and decision making within the purview of the project manager.
Every company is different and will face different challenges. Here, we provide the most relevant ones, which are likely to affect most companies to some degree.
Customer needs are forgotten. Traditionally, companies work in siloed departments where each of them is responsible for a particular function within the company. The risk in such a setup is that the customers' interests are prioritized only at the highest levels of decision making. When it comes to actual work that the customers have to interface with (marketing material, customer support, product, etc.) employees start focusing more on the output rather than the outcome. The work becomes about creating a leaflet and not about conveying information, about closing support tickets and not helping customers.
Scarce feedback from clients. Stemming from the previous point, if customers needs are not prioritized, then likely feedback from them is also not sought out or properly captured when it does appear. This makes it much harder to figure out how to improve the product or service—especially so when you are trying to restructure everything around digital capabilities. Digital transformation even for a large enterprise is a startup scenario. It is full of unknowns and requires constant feedback from clients to provide the right solutions to the market.
Data is not used in decision-making. When you are creating custom software, it is much easier to capture and analyze data. Most companies have financial data but not a lot of usage statistics. This leads to decisions being made based on gut feeling. Using data to support one's decisions requires a different mindset and a new set of internal capabilities to have this data ready.
When we talk about digital transformation, we most often refer to companies like Domino's and John Deere, where the primary line of business is not related to IT. That is not to say that IT companies do not go over digital transformations. For example, in 2016, Google declared it will be moving from a mobile-first strategy to being AI-first. This is another form of digital transformation, but in this section, we will be looking at traditionally non-IT companies.
No project manager can singlehandedly make or break a digital transformation because it is a company-wide effort. Having said that, PMs can be effective in the scope of their responsibilities, which would definitely improve the chances of a successful transformation. Moreover, it can lead to better career opportunities within the company as the people who are most effective during the transformation are poised to be well-adapted for the new digital reality in the company.
Agile is currently the most widespread methodology of delivering digital projects, and it will inevitably become a key component of any digital transformation. Whether your company uses Scrum, Kanban, or any of the scaled Agile frameworks does not really matter. All of them adhere to the values outlined in the Agile Manifesto.
An effective PM should be able to communicate the principles of Agile to both their team and colleagues from other parts of the organization. You should be able to challenge the old modes of working and engage stakeholders in figuring out how to make the internal processes more agile.
While the previous section talked about being able to challenge the status quo, it is very important to recognize and respect the legacy processes currently in play. There are two main reasons for this advice.
Firstly and very pragmatically, habits don't change quickly and people, in general, don't like to change the way they are used to working. Even if you have some affirmation from senior leadership that the whole company has to become more agile it would not be wise to force someone. You are likely to face resistance and come into conflicts with your colleagues.
Secondly, not all teams should work fully or at all based on Agile principles. Agile is not a silver bullet, and this is even more apparent in non-IT companies. Different departments have different levels of responsibility and risk, and not all of them can behave as software teams would. Mistakes for the legal or finance teams can be much more costly and harder to roll back than a bug in a client-facing platform.
Consider yourself more of an Agile coach. Before rushing to change how a team is working, figure out what led to the creation of the current processes. Be humble, as there might be important reasons behind those decisions.
Take a good look at how your company interacts with clients now. And then review what exposure to clients you have yourself. Is it just customer support who are talking to users? Or just salespeople working with decision makers? Or, as a project manager, do you mostly interact with clients at the beginning and at the end of the project?
Even though it is perfectly possible to deliver projects without consulting with clients very often, many projects face problems of unmet or changing expectations when clients see the end result. While it might be hard to involve customers in the development process of non-IT products, digital opens up new capabilities. Being able to release software often allows a PM to engage the clients more and gather their feedback on a constant basis. This helps align requirements early on and avoid problems at the end of the project.
Digital opens up new ways for your company to interact with users. The most important characteristic is that users are able to access your product or service whenever they want and be able to achieve some goal almost instantly. A lot of traditional interactions make the customers wait: email reply from customer support, account setup from an account manager, etc.
If you have big volumes of repetitive customer support issues, then it's worth considering to create help pages or community-driven forums. Another option to explore is chatbots. With respect to account management, creating self-service systems will not only create more immediacy for the users but can also save time for your colleagues as some tasks are shifted to the users.
Digital transformation should not be glorified and applied in all and any circumstances. Most local businesses might only need some digital capabilities without overgoing a digital transformation to be successful. One clear example of this is UK bookshop chain Waterstones. In 2017, the company declared it was profitable again after a long period of poor results. It achieved this through a strategy of localization and differentiation against its digital competitors like Amazon. This is becoming more relevant as consumers are looking for authentic local and physical experiences that could counterbalance their digitally oversaturated lives.
Two characteristics of a product or service can be used to assess the need for a digital transformation. Firstly, where are the customers coming from? And secondly, how would you like your customers to interact with your business?
If the answer to either one of these questions is from the digital domain, your company is most likely going to benefit from the digital transformation.
Even if this question is never asked, most global businesses will be driven to become digital by the competition as future innovations come from digital technologies.
However, most local businesses like coffee shops, kiosks, and small retailers provide local services and don't need to think about digital channels in the same way that digital-first companies do. Secondly, the importance of the physical component in a product or service can also indicate if a digital transformation is inevitable. Dining at a high-end restaurant or buying flowers are very physical activities. Digital capabilities might improve them to a small degree, but that does not call for a full digital transformation.
Project managers are some of the most crucial people during a digital transformation as it requires both a cultural shift and ability to adapt to changing market conditions and new technologies. Effective PMs will use Agile frameworks to deliver their project and spread Agile values to other teams and departments. Changing market conditions and the ability to deploy working software often will require the PM to create feedback loops with clients. Lastly, reframing interactions with users will allow the company to remain competitive by creating immediate outcomes for users.
Digital transformation is a restructuring of products and services around digital capabilities. It can include redesigning the sales channels, introducing software development or capturing and analyzing customer data.
Digital transformation strategy outlines a plan of action to achieve a restructuring of products and services around digital capabilities.
Digital transformation is becoming critical for a lot of companies. According to IDG's State of Digital Business Transformation, 89% of organizations adopted or have plans to adopt a digital-first strategy in 2018.
How do you start a digital transformation?
A digital transformation can be started by analyzing the market to understand how digital capabilities have changed client behavior and then developing a strategy on how to restructure existing products and services to meet the new usage patterns.
Digital transformation is becoming more and more important as new digital technologies are developed. This changes how people search for information and make buying decisions. Many traditional businesses have to restructure their products and services around new digital capabilities to remain competitive.


text:
In Comparison: Dress Code
By Luke Mott '19
"I want my sweatpants back," yells Isabella Houle '19 from across the lawn of the Washington National Cathedral. Here at the Cathedral Close, dress codes are a controversial topic.
When discussing the issue of a dress code in education, people usually turn to studies and science that compare school dress and academic performance. Many studies argue that a dress code leads to academic prosperity. Many studies disprove such a link. There is no consensus on the matter. There is certainly no consensus on the Close.
At St. Albans, students must wear a blazer or sportcoat, a tie and a collared shirt, a belt, and solid-color pants or shorts. Turtlenecks are also acceptable. Instead of clothing requirements, NCS prohibits specific articles: leggings, yoga pants, pajamas, and sweatpants.
Some people enjoy their schools' dress codes. Nolan Musslewhite, a sophomore, loves the STA dress code. Eleanor Boomhower, an NCS freshman, says, "I like the dress code. It allows me to wear what I want. I don't really own sweatpants." Richard Davies-Van Voorhis, a freshman, enjoys the STA dress code because "it creates opportunities to emulate your own style while remaining within the tradition of formal dress, giving the student body an aura of gravitas."
Many more despise the codes. "Damn the dress code." Over the course of my research for this article, fourteen people screamed this or some profane variant at me. "I hate the dress code," says Sarah Muoio, an NCS freshman. "I don't own clothing that fits the dress code, not because I like to dress 'scandalously,' but because I happen to not own five pairs of denim non-ripped jeans." "What irritates me the most," reflects Katharine Boasberg, an NCS senior, "is trying to find shorts with a five-inch inseam, which very few companies produce." "The new dress code has cut my wardrobe in half," says Taliyah Emory-Muhammad, an NCS junior.
Most people are ambivalent about the dress code. Noah Kang, an STA junior, says he is "fine with the dress code," but he thinks "changes need to be made." Kang feels that sometimes STA students should be allowed to wear polo shirts and sweatshirts. "I appreciate there being boundaries," he says, "but those boundaries are often too strict." Zoé Contreras-Villalta, an NCS junior, says she thinks the dress code is "irrelevant to how [she] functions at school," adding, "I like jeans. I don't need pajamas in class." Mady Jones, an NCS senior, thinks that "either you should have a uniform or no dress code at all. You can't restrict some things [e.g., ripped jeans, leggings] but not others.
There are many opinions on the dress code, but, overall, most NCS girls want sweatpants. Most STA guys don't care.


text:
Judy Cornwell to Howard Da Silva
Robert Cuccioli Biography (1958-)
Born May 3, 1958, in Hempstead, NY. Addresses: Agent: HWA Talent Representatives, 36 East 22nd St., 3rd Floor, New York, NY 10010.
Hempstead, New York, United States
Stage Appearances
H.M.S. Pinafore, Broadway production, 1982
(As Bob Cuccioli) Professor Lawrence Lake/Sir Lancelot, A ConnecticutYankee, All Souls Fellowship Hall, 1986
(As Bob Cuccioli) Pontius Pilate, Jesus Christ Superstar, Paper Mill Playhouse, Millburn, NJ, 1987-1988
(As Bob Cuccioli) Count Danilo, The Merry Widow, Light Opera of Manhattan, New York City, 1988
(As Bob Cuccioli) Joe, Ankles Aweigh, Goodspeed Opera House, EastHaddam, CT, 1988-1989
(As Bob Cuccioli) Edward Rutledge, La cage aux folles, Paper MillPlayhouse, 1988-1989
(As Bob Cuccioli) Gaston, Gigi, Equity Library Theatre, New York City, 1989
(As Bob Cuccioli) Nathan Rothschild, The Rothschilds, American Jewish Theatre, New York City, 1990, then Circle in the Square Theatre-Downtown,New York City, 1990-1991
(As Bob Cuccioli) Tito, Lend Me a Tenor, Paper Mill Playhouse, 1990-1991
And the World Goes 'Round, Westside Theatre, New York City, 1991
Jud, Oklahoma, Paper Mill Playhouse, 1991-1992
Javert, Les miserables, Imperial Theatre, New York City, 1993-1995
Henry Jekyll/Edward Hyde, Jekyll & Hyde, Plymouth Theatre, NewYork City, 1997-1999
Archibald Craven, The Secret Garden, San Francisco, CA, 1999
Henry Lord, Dorian, Los Angeles Theater Center, Los Angeles, 1999
Guille, The Sons of Don Juan, San Jose Repertory Theater, San Jose, CA, 2000
Hero, Arci's Place, New York City, 2000
Sid Sorokin, The Pajama Game, The Pittsburgh Civic Light Opera, Pittsburgh, PA, 2000
Macheath "Mack the Knife," Threepenny Opera, Lucille Lortel Theatre, New York City, 2000
King Marchan, Victor/Victoria, Paper Mill Playhouse, 2000
Enter the Guardsman, Dimson Theatre, New York City, 2000
Joseph Surface, The School for Scandal, McCarter Theatre, Princeton, NJ, 2001
Mark Antony, Antony and Cleopatra, F.M. Kirby Shakespeare Theatre,Madison, NJ, 2000
Nicky Arnstein, Funny Girl, Paper Mill Playhouse, 2001
Jeff Moss, Bells Are Ringing, Benedum Center, 2001
A Little Night Music, Seattle, WA, 2001
Antony, Antony, Guthrie Theatre, Minneapolis, MN, 2002
Paul Berthalet, Carnival!, New Jersey Shakespeare Festival, 2002
Sky Masterson, Guys and Dolls, Bendedum Theatre, Pittsburgh, PA, 2002
Karl Streber, Temporary Help, Women's Project Theater, New York City, 2002
Also appeared in Senor Discretion; The Fantasticks; Pirates of Penzance; City of Angels; Phantom; 1776; andCarousel.
(As Bob Cuccioli) Lancelot du Lac, Camelot, U.S. and Canadian cities, 1985-1986
Also toured in Jekyll & Hyde, U.S. cities.
Interviewee, Broadway '97: Launching the Tonys, CBS, 1997
Aidan "The Phantom" Masters, "Nevermore," Baywatch, 1997
Paxton, "Heavy Metal," Sliders, Fox, 1999
Appeared in episodes of One Life to Live and All My Children.
John, Clear Target, 1997
Monroe Gordon, Celebrity, Miramax, 1998
John, Operation Delta Force 3: Clear Target (also known as Clear Target), Image Entertainment, 1998
The man, The Stranger, Fusion International, 1999
Sean Alford, Spoken in Silence, Evans & Turner Entertainment,1999
Butterfly Legend, 1999
Director and producer, Cliff Walk, 1999
Contributed to Jekyll & Hyde (Broadway cast recording) and And the World Goes 'Round.
Cliff Walk, 1999


This eye concentrate helps to refresh tired eyes and eye bags and attacks dark circles and powerfully reduce appearance of fine lines and wrinkles.
Directions: Apply suitable amount to cleansed eye contour with a gentle upward circular motion in the morning and evening.
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Note: You only need to read this document if you're using a customized or proprietary porting layer based on Pelion Device Management 1.2. If you are using the reference porting layers provided with later releases, you do not need to make any manual changes.
We've added many features and security enhancements since 1.2, which have implications for the PAL porting layer. This guide helps you make the adjustments required when upgrading to the current version.
Please see the minimum requirements configuration in the device requirements document.
Software One Time Programming (SOTP).
(D)TLS handshake supports (D)TLS renegotiation.


This addition and remodel brings modern amenities and efficiencies to a traditional Berkeley craftsman house built in 1909. The client, an avid cook and former professional baker, wanted a restaurant quality kitchen work-space and commercial grade appliances without sacrificing the warm feeling of the traditional house. The Douglas fir wood floor and ceiling details add warmth to the space, complemented by chalky whites and dark grays. A generous island grounds the room and becomes the focal point for baking and eating. The end panels of the kitchen island can be removed to allow for cooling racks. Light washes over the hand-plastered walls in the bathrooms.


text:
Series 1 Episode 1
Graphic scenes of surgery and full frontal nudity This episode is subtitled48 mins
The second programme meets a husband and wife couple with a combined weight of 52 stone, and a 21-year-old Mum whose life is maligned by her enormous J cup breasts.
Full frontal nudity, graphic scenes of surgery and intimate examinations This episode is subtitled48 mins
Dr Pixie comes face to face with three huge hernias, and Dr Christian meets Malissa Jones, who made headlines in 2008, for being the world's first teenager to undergo a gastric band operation.
Full frontal nudity and graphic scenes of surgery This episode is subtitled47 mins
The doctors deal with the impact obesity has on fertility, the largest man boobs Dr Pixie has ever seen, and excess hair caused by polycystic ovaries.
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text:
Q: Suppress asyncio runtime errors in Python on exit? I'm working on a discord bot using discord.py, and am trying to make the bot easy to kill without throwing up a bunch of errors to make it easier to work on further. I have tried all sorts of exception/error suppression methods, such as the Try/Except pass, but to no avail.
import discord,time
try:
    config = open('config.ini','r')
    botToken= config.readline()[7:]
    log_outfile = open('file','w')
    class Client(discord.Client):
        async def on_ready(self):
            print(time.asctime()[11:20] + '| Logged on as {0}'.format(self.user))
            log_outfile.writelines(time.asctime()[11:20] + '| Logged on as {0}\n'.format(self.user))
            log_outfile.flush()

        async def on_message(self, message):
            print(time.asctime()[11:20] + '| Message from {0.author} in server {0.guild} in channel {0.channel}: {0.content}'.format(message))

            log_outfile.writelines(time.asctime()[11:20] + '| Message from {0.author} in server {0.guild} in channel {0.channel}: {0.content}\n'.format(message))
            log_outfile.flush()

    botClient = Client()
    try:
        botClient.run(botToken)
    except TimeoutError:
        print('Connection timed out. Please ensure a stable connection for optimal bot functionality.')
    except discord.LoginFailure:
        print("That token didn't work. Try changing the token in config.ini")
        exit()
except KeyboardInterrupt:
    pass
    log_outfile.close()        ##I'm not sure if formatting is right since I just copy-pasted parts of my code so as to not reveal anything.

to which, when I ctrl + c, it outputs:
Exception ignored in: <function _ProactorBasePipeTransport.__del__ at 0x000001D08F202790>
Traceback (most recent call last):
  File "C:\Program Files\WindowsApps\PythonSoftwareFoundation.Python.3.9_3.9.3312.0_x64__qbz5n2kfra8p0\lib\asyncio\proactor_events.py", line 116, in __del__
    self.close()
  File "C:\Program Files\WindowsApps\PythonSoftwareFoundation.Python.3.9_3.9.3312.0_x64__qbz5n2kfra8p0\lib\asyncio\proactor_events.py", line 108, in close
    self._loop.call_soon(self._call_connection_lost, None)
  File "C:\Program Files\WindowsApps\PythonSoftwareFoundation.Python.3.9_3.9.3312.0_x64__qbz5n2kfra8p0\lib\asyncio\base_events.py", line 751, in call_soon
    self._check_closed()
  File "C:\Program Files\WindowsApps\PythonSoftwareFoundation.Python.3.9_3.9.3312.0_x64__qbz5n2kfra8p0\lib\asyncio\base_events.py", line 515, in _check_closed
    raise RuntimeError('Event loop is closed')
RuntimeError: Event loop is closed
Exception ignored in: <function _ProactorBasePipeTransport.__del__ at 0x000001D08F202790>
Traceback (most recent call last):
  File "C:\Program Files\WindowsApps\PythonSoftwareFoundation.Python.3.9_3.9.3312.0_x64__qbz5n2kfra8p0\lib\asyncio\proactor_events.py", line 116, in __del__
  File "C:\Program Files\WindowsApps\PythonSoftwareFoundation.Python.3.9_3.9.3312.0_x64__qbz5n2kfra8p0\lib\asyncio\proactor_events.py", line 108, in close
  File "C:\Program Files\WindowsApps\PythonSoftwareFoundation.Python.3.9_3.9.3312.0_x64__qbz5n2kfra8p0\lib\asyncio\base_events.py", line 751, in call_soon
  File "C:\Program Files\WindowsApps\PythonSoftwareFoundation.Python.3.9_3.9.3312.0_x64__qbz5n2kfra8p0\lib\asyncio\base_events.py", line 515, in _check_closed
RuntimeError: Event loop is closed
C:\Bot\Directory

Help?

redpajama_set_name: RedPajamaStackExchange


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text:
Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA
R. Stephen Lloyd, Charles W. Haidle, Roger R. Hewitt
Bleomycin-induced breakage of an isolated covalently closed circular DNA from bacteriophage PM2 was assayed fluorometrically after agarose gel electrophoresis and staining with ethidium bromide. When bleomycin-damaged DNA was assayed under neutral conditions, there was a decrease in the amount of Form I DNA and a simultaneous increase in both Forms II and III of DNA. However, when the damage was assayed under nondenaturing alkaline conditions, there was a greater decrease in the amount of Form I DNA and a corresponding increase in both Forms II and III DNA compared with neutral conditions. Approximately one alkaline-labile site was formed for every single-strand break introduced. The rate of formation of Form III DNA was found to be approximately twice as fast when measured under alkaline conditions compared with neutral condftions. Reaction of bleomycin-treated PM2 DNA with the Escherichia coil apurinic specific endonuclease IV demonstrated that the loss of Form I DNA was very similar to that observed with alkali treatment suggesting that the bleomycin-induced alkaline-labile damage is the result of base removal from the DNA helix. Similar results were obtained when the bleomycin-treated DNA was reacted with E. coli endonuclease III. However, no increase in double-strand breakage was observed with either endonuclease III or IV, which may reflect an inability of the endonuclease to cleave at a site of base loss across from a single-strand break or another lost base. Alkali treatment of purified Form I DNA which was pretreated with bleomycin revealed that some of the alkali-induced double-strand breaks arose from Form I molecules, suggesting that two alkaline-labile sites are formed across from each other. In addition, some Form II molecules produced by bleomycin treatment were converted to Form III molecules by non-denaturing alkaline conditions.
Dive into the research topics of 'Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA'. Together they form a unique fingerprint.
Bleomycin Medicine & Life Sciences 100%
Alkalies Medicine & Life Sciences 29%
Endonucleases Medicine & Life Sciences 19%
E coli NTH protein Medicine & Life Sciences 16%
Corticoviridae Medicine & Life Sciences 15%
Deoxyribonuclease IV (Phage T4-Induced) Medicine & Life Sciences 14%
DNA-(Apurinic or Apyrimidinic Site) Lyase Medicine & Life Sciences 11%
Lloyd, R. S., Haidle, C. W., & Hewitt, R. R. (1978). Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA. Cancer Research, 38(10), 3191-3196.
Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA. / Lloyd, R. Stephen; Haidle, Charles W.; Hewitt, Roger R.
In: Cancer Research, Vol. 38, No. 10, 10.1978, p. 3191-3196.
Lloyd, RS, Haidle, CW & Hewitt, RR 1978, 'Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA', Cancer Research, vol. 38, no. 10, pp. 3191-3196.
Lloyd RS, Haidle CW, Hewitt RR. Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA. Cancer Research. 1978 Oct;38(10):3191-3196.
Lloyd, R. Stephen ; Haidle, Charles W. ; Hewitt, Roger R. / Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA. In: Cancer Research. 1978 ; Vol. 38, No. 10. pp. 3191-3196.
@article{6f5bed2520214885a0a67139925905df,
title = "Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA",
abstract = "Bleomycin-induced breakage of an isolated covalently closed circular DNA from bacteriophage PM2 was assayed fluorometrically after agarose gel electrophoresis and staining with ethidium bromide. When bleomycin-damaged DNA was assayed under neutral conditions, there was a decrease in the amount of Form I DNA and a simultaneous increase in both Forms II and III of DNA. However, when the damage was assayed under nondenaturing alkaline conditions, there was a greater decrease in the amount of Form I DNA and a corresponding increase in both Forms II and III DNA compared with neutral conditions. Approximately one alkaline-labile site was formed for every single-strand break introduced. The rate of formation of Form III DNA was found to be approximately twice as fast when measured under alkaline conditions compared with neutral condftions. Reaction of bleomycin-treated PM2 DNA with the Escherichia coil apurinic specific endonuclease IV demonstrated that the loss of Form I DNA was very similar to that observed with alkali treatment suggesting that the bleomycin-induced alkaline-labile damage is the result of base removal from the DNA helix. Similar results were obtained when the bleomycin-treated DNA was reacted with E. coli endonuclease III. However, no increase in double-strand breakage was observed with either endonuclease III or IV, which may reflect an inability of the endonuclease to cleave at a site of base loss across from a single-strand break or another lost base. Alkali treatment of purified Form I DNA which was pretreated with bleomycin revealed that some of the alkali-induced double-strand breaks arose from Form I molecules, suggesting that two alkaline-labile sites are formed across from each other. In addition, some Form II molecules produced by bleomycin treatment were converted to Form III molecules by non-denaturing alkaline conditions.",
author = "Lloyd, {R. Stephen} and Haidle, {Charles W.} and Hewitt, {Roger R.}",
T1 - Bleomycin-induced Alkaline-labile Damage and Direct Strand Breakage of PM2 DNA
AU - Lloyd, R. Stephen
AU - Haidle, Charles W.
AU - Hewitt, Roger R.
N2 - Bleomycin-induced breakage of an isolated covalently closed circular DNA from bacteriophage PM2 was assayed fluorometrically after agarose gel electrophoresis and staining with ethidium bromide. When bleomycin-damaged DNA was assayed under neutral conditions, there was a decrease in the amount of Form I DNA and a simultaneous increase in both Forms II and III of DNA. However, when the damage was assayed under nondenaturing alkaline conditions, there was a greater decrease in the amount of Form I DNA and a corresponding increase in both Forms II and III DNA compared with neutral conditions. Approximately one alkaline-labile site was formed for every single-strand break introduced. The rate of formation of Form III DNA was found to be approximately twice as fast when measured under alkaline conditions compared with neutral condftions. Reaction of bleomycin-treated PM2 DNA with the Escherichia coil apurinic specific endonuclease IV demonstrated that the loss of Form I DNA was very similar to that observed with alkali treatment suggesting that the bleomycin-induced alkaline-labile damage is the result of base removal from the DNA helix. Similar results were obtained when the bleomycin-treated DNA was reacted with E. coli endonuclease III. However, no increase in double-strand breakage was observed with either endonuclease III or IV, which may reflect an inability of the endonuclease to cleave at a site of base loss across from a single-strand break or another lost base. Alkali treatment of purified Form I DNA which was pretreated with bleomycin revealed that some of the alkali-induced double-strand breaks arose from Form I molecules, suggesting that two alkaline-labile sites are formed across from each other. In addition, some Form II molecules produced by bleomycin treatment were converted to Form III molecules by non-denaturing alkaline conditions.
AB - Bleomycin-induced breakage of an isolated covalently closed circular DNA from bacteriophage PM2 was assayed fluorometrically after agarose gel electrophoresis and staining with ethidium bromide. When bleomycin-damaged DNA was assayed under neutral conditions, there was a decrease in the amount of Form I DNA and a simultaneous increase in both Forms II and III of DNA. However, when the damage was assayed under nondenaturing alkaline conditions, there was a greater decrease in the amount of Form I DNA and a corresponding increase in both Forms II and III DNA compared with neutral conditions. Approximately one alkaline-labile site was formed for every single-strand break introduced. The rate of formation of Form III DNA was found to be approximately twice as fast when measured under alkaline conditions compared with neutral condftions. Reaction of bleomycin-treated PM2 DNA with the Escherichia coil apurinic specific endonuclease IV demonstrated that the loss of Form I DNA was very similar to that observed with alkali treatment suggesting that the bleomycin-induced alkaline-labile damage is the result of base removal from the DNA helix. Similar results were obtained when the bleomycin-treated DNA was reacted with E. coli endonuclease III. However, no increase in double-strand breakage was observed with either endonuclease III or IV, which may reflect an inability of the endonuclease to cleave at a site of base loss across from a single-strand break or another lost base. Alkali treatment of purified Form I DNA which was pretreated with bleomycin revealed that some of the alkali-induced double-strand breaks arose from Form I molecules, suggesting that two alkaline-labile sites are formed across from each other. In addition, some Form II molecules produced by bleomycin treatment were converted to Form III molecules by non-denaturing alkaline conditions.
C2 - 80262


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Ishat Reza
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Prior to her legal career, Ishat was a Lead International Negotiator for the Government of Canada where she led bilateral negotiations on trade in goods, agriculture, safeguards, tariffs and technical barriers to trade, with countries in Asia, Latin America, the Caribbean, Europe and the Middle East.
Ishat Reza is a workplace investigator with a background in employment and human rights law. She specializes in discrimination, harassment and sexual violence claims, and conducts independent, thorough and timely investigations. Ishat also provides guidance to organizations on a wide range of institutional policies and programs. She is fair, thorough and service-oriented, and handles sensitive workplace issues with confidentiality, care and a trauma-informed approach.
Ishat began her legal career as a litigator at Torys LLP where she worked on diverse issues including employment law, human rights (such as disability legislation and sexual harassment cases), and equality rights and religious freedoms under the Canadian Charter of Rights and Freedoms. She has been a Member of the Law Society of Ontario since 2012, and holds LL.B. and B.C.L. degrees from McGill University, a Master of Arts from Harvard University and an Honours Bachelor of Arts degree with high distinction from the University of Toronto.
Prior to her legal career, Ishat was a Lead International Negotiator for the Government of Canada where she led bilateral negotiations on trade in goods, agriculture, safeguards, tariffs and technical barriers to trade, with countries in Asia, Latin America, the Caribbean, Europe and the Middle East. She also represented Canada at the World Trade Organization in Geneva during the Doha Development Round of negotiations.
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Ishat leverages her diverse experiences to provide a contextualized and well-rounded approach to her current workplace assessment and investigation work.


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More info on Steam donkey
Design and usage
Method of operation
Steam donkey: Wikis
Categories: Calaveras County, California > Eureka, California > Log transport > Logging > Steam power
12 x 14 Empire (?) Steam donkey in the UBC Malcolm Knapp Research Forest, Maple Ridge, BC Canada
Steam donkey, or donkey engine is the common nickname for a steam-powered winch, or logging engine widely used in past logging operations, though not limited to logging. They were also found in the mining, maritime, and nearly any other industry that needed a powered winch.
1 Design and usage
2 Method of operation
4 Other uses
Steam donkeys acquired their name from their origin in sailing ships, where the "donkey" engine was typically a small secondary engine used to load and unload cargo and raise the larger sails with small crews, or to power pumps. They were classified by their cylinder type – simplex (single-acting cylinder), or duplex (a compound engine); by their connection to the winches (or "drums") – triple-drum, double-drum, etc; and by their different uses: high-lead yarder, ground-lead yarder, loader, snubber, incline hoist, etc. A good deal of the cable-logging terminology derived from 19th century merchant sailing, as much of the early technology originated from that industry.
A logging engine comprised at least one powered winch around which was wound hemp rope or (later) steel cable. They were usually fitted with a boiler, and usually equipped with skids, or sleds made from logs, to aid them during transit from one "setting" to the next. The larger steam donkeys often had a "donkey house" (a makeshift shelter for the crew) built either on the skids or as a separate structure. Usually a water tank, and sometimes a fuel oil tank was mounted on the back of the sled. In rare cases, steam donkeys were also mounted on wheels. Later steam donkeys were built with multiple horizontally-mounted drums/spools, on which were wound heavy steel cable instead of the original rope.
Dolbeer "Logging Engine"
(Patent 256,553)
This describes the use of a steam donkey for logging operations. In the simplest setup, a "line horse" would carry the cable out to a log in the woods. The cable would be attached, and, on signal, the steam donkey's operator (engineer) would open the regulator, allowing the steam donkey to drag or "skid" the log towards it. The log was taken either to a mill or to a "landing" where the log would be transferred for onward shipment by rail, road or river (either loaded onto boats or floated directly in the water). Later a "haulback" drum was added, where a smaller cable could be routed around the "setting" and connected to the end of the heavier "mainline" to replace the line horse.
If a donkey was to be moved, one of its cables was attached to a tree, stump or other strong anchor, and the machine would drag itself overland to the next yarding location.
Steam donkey on display at Disney's California Adventure theme park
John Dolbeer, a founding partner of the Dolbeer and Carson Lumber Company in Eureka, California, invented the logging engine in that city[1] in August 1881. The patent (number: 256553) was issued April 18, 1882. On Dolbeer's first model, a 150-foot, 4½ inch manila rope was wrapped several times around a gypsy head (vertically mounted spool) and attached at the other end to a log.[2][3]
The invention of the internal-combustion engine led to the development of the diesel-powered tractor crawler, which eventually put an end to the steam donkey. Though some have been preserved in museums, very few are in operating order. A great number still sit abandoned in the forests, rusting in the spot where they dropped their fires not so long ago.
An operational steam donkey is on display and occasionally operated at Fort Humboldt State Historic Park in Eureka. A non-operational steam donkey accompanied by a plaque explaining the history of the machine is on permanent display at Grizzly River Run, an attraction at Disney's California Adventure. Another collection of steam donkeys is located at the Point Definance Park, Camp 6 Logging Museum located in Tacoma, Washington. The collection includes various steam donkeys, including one of the last very large ones built, and others at various stages of restoration.
On August 1, 2009 a Steam Donkey was officially unveiled at McLean Mill National Historic Site in Port Alberni, British Columbia. It is now the only commercially operating Steam Donkey in North America. Due to extreme fire risk, demonstrations of the donkey was not performed but the logs from previous test runs of the donkey that were loaded onto a truck were dumped into the McLean Mill millpond, representing the first steam-powered commercial logging operation in North America for decades. This machine continued to operate after R. B. Mclean shuttered the steam-powered McLean Mill site in 1965. It ran until 1972 and was abandoned on site. It was restored by the Alberni Valley Industrial Heritage Society in 1986 for Expo 86 and more recently was recertified for commercial use at McLean Mill. Agreements have been made with forest land owner Island Timberlands (owned by Brookfield Asset Managements) to log, mill, and sell, trees and lumber from the surroundings of McLean Mill.
Steam donkeys were also found to be useful for powering other machines such as pile drivers, slide-back loaders (also known as slide-jammers), and cherry-pickers (a sled-mounted crane used for loading logs, that a grading crew had cut down, onto railroad cars).
An auxiliary engine on a sailing craft (which does propel the vessel) is still sometimes informally known as "the donk".
Yarder – a larger steam-powered logging machine
Lidgerwood – manufacturer of steam-powered logging equipment
Geared steam locomotive – often used on forestry railways
^ History of Eureka, California - Timeline of Historically Significant Events
^ Wilma, David (March 1, 2003). "John Dolbeer invents the donkey engine and revolutionizes logging in August 1881.". HistoryLink.org. http://www.historylink.org/essays/output.cfm?file_id=5331. Retrieved 2007-02-27.
^ Richard L. Williams, The Loggers, (New York: Time-Life Books, 1976), 112-113; ISBN 0-8094-1527-5
The Anatomy of a Steam Donkey – (image)
Steam Donkeys
The Donkey Engine – Steam & Engine of Australia
Turtle Bay Exploration Park's Dolbeer Steam Donkey (video)
Steam Power – Pacific County Historical Society and Museum
University of Washington Libraries: Digital Collections:
Categories: Steam power | Logging | Log transport | Eureka, California
Up to date as of November 16, 2009
Steam Power
Darius Kinsey Photographs - ::: Darius Kinsey Photographs :::
Clark Kinsey Photographs - ::: Clark Kinsey Photographs Collection :::
University of Washington Libraries: Digital Collections - ::: UW Libraries Digital Collections :::
The Donkey Engine - Steam & Engine of Australia - The Donkey Engine
The Anatomy of a Steam Donkey
John Dolbeer invents the donkey engine and revolutionizes logging in August 1881. - HistoryLink.org- the Free Online Encyclopedia of Washington State History
(number: 256553) - LOGGING-ENGINE - Google Patent Search


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Authorities pledge clampdown on car clocking
https://english.radio.cz/authorities-pledge-clampdown-car-clocking-8297798#player=on
Photo: Ondřej Jánoška
Czech officials have pledged to crack down on the widespread practice of altering used cars' mileage. It is estimated that half of all second-hand vehicles sold are "clocked", costing customers dozens of billions each year. The Ministry of Industry and Trade now wants to make mileage manipulation a criminal offense.
An estimated 570,000 used cars were sold in the Czech Republic last year which means that for every new car, more than three pre-owned vehicles were sold. But experts warn that about half of them were "clocked", that is, their mileage was altered to get a higher price from the buyer. Industry and Trade Minister Jan Mládek outlined the scope of the problem at a news conference on Wednesday.
"Czech consumers are being cheated on a mass scale. They buy old cars at multiples of their real values. They lose billions of crowns every year on pre-owned cars which pose a threat to the environment as well as to the safety of their owners and other drivers on the road."
There are around 1,200 used cars dealerships in the Czech Republic which last year sold around 260,000 vehicles; the remaining cars were sold privately. But there are also at least 29 companies which publicly advertise that for a small fee, they will alter the cars' mileage so that the seller can get a better price, and dealers have a quicker turnover.
The practice can be punished using Czech anti-fraud legislation but officials say that no such case has ever been brought before court. Minister Mládek says that in cooperation with other government branches, he will push for new, stricter legislation to curb the practice.
Jan Mládek, photo: Filip Jandourek
"We need to make this a criminal offense so that people who do this could end up in prison. But we will also need to introduce other measures. For instance, authorized service stations should set up databases to provide alternative sources of information about the vehicles."
Consumer groups have welcomed the initiative. They say additional sources of information about second-hand cars are crucial as better-informed buyers are less likely to buy "clocked" cars. Zbyněk Veselý is the head of Sova, a Czech association of car owners.
"Plans to make car clocking a crime won't completely do away with the issue. But I expect that it will dramatically lower the frequency of the fraud which is now being publicly committed, and is advertised on the internet."
However, nearly half of all the used cars sold in the country last year went for 100,000 crowns or less. That makes some experts believe that car clocking will only become less frequent when Czechs are able to pay more for the cars in the first place.
Author: Jan Richter
Old cars must be dismantled in official scrap yards under new EU regulations
Used car dealers feeling crunch – daily


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This is the best product of blank media that I've ever used.


text:
Contact Lil
I started writing BOYS FOR BEGINNERS when I was 11. My best friend Kate was feeling down so I thought I would write her a story to cheer her up. I called it Gwynnie Goes Girlie, wrote it in pencil and did drawings to illustrate it too.
Writing a book takes a lot of hard work and discipline. I'm finding that now as an adult, and definitely found that as a girl. Unfortunately I never finished that original version; it was 41 pages and only made it as far as chapter 8.
But I never forgot the story. Years later I mentioned it to my agent she said I should try writing it. I went over to my parents' house, searched long and hard in their cobwebby attic, and found a brightly coloured Velcro file which contained the original manuscript!
The spelling was atrocious but it was so much more than I remembered. Everything that is in BFB comes from that original manuscript, it's just spelled correctly now… I hope.
A lot of the characters are a jigsaw of people I've known: from back when I was 11 and people in my life now.
Gwynnie was based on my best friend Kate. Kate was skinny, a tomboy who played football with the boys (we both were) and she never ever wore skirts. There was eventually a time when she "went girlie". However, I would say that now Gwynnie is more based on my own experiences at that age – learning to behave in a new way and getting it wrong. A lot!
Kate is still my best friend.
Paul is Gwynnie's best friend in the book. Back then he was based on a boy who I was friends with at school, called Paul. Paul supported Tottenham Hotspur and that's why Gwynnie supports Tottenham Hotspur. I met up with the real Paul recently – he hasn't changed a bit – except he's married with three children.
But Paul's personality is based on my close friend Tom. Being friends with a boy is very different from being friends with a girl; both are rewarding, but in their own way.
Gwynnie's Dad is sort of based on my dad: his hair is ginger but not frizzy; my dad doesn't like football that much; and he doesn't work in a sports shop. But he is as nice as Gwynnie's dad and he can be a bit gormless sometimes. The character is who my dad would be if my mum had died when my siblings and I were young. I think he would have got a lot of stuff wrong, but his heart would always have been in the right place.
Jenny is a girlie girl and a bit of a bitch. I think she was based on a girl at school who I was jealous of because she used to be a geek but then she grew boobs and her hair became longer and blonder and prettier and all the boys fancied her.
But I'm ashamed to say that Jenny is also based on me too – my worst side. I channel all my mean thoughts into the character of Jenny and she takes it from there. It's probably quite healthy.
© Lil Chase 2022 | Web Design by PIH


The impossibly seamless 'Cloud Gate' sculpture, more colloquially known as 'The Bean'. Located in Millennium Park, it may not be the most famous landmark in Chicago, but it was the one we wanted to visit first.
Chicago's high-rises sure are pretty.
Trees in alignment on the Chicago waterfront next to Lakeshore Drive.
With the city flanking Lake Michigan, one would expect Chicago to have a vibrant water-recreation scene, and indeed it does.
We are at the entrance of the Chicago river as it flows in from Lake Michigan and onwards snaking through downtown.
The incredibly scenic Chicago River. Touring the length on boat is highly recommended.
I definitely had 'The Dark Knight' flashbacks whilst on the Chicago River boat tour. Chicago is indeed Gotham city come to life.
It's unfair for Chicago to have a river running through its downtown. I mean, of course it's going to look gorgeous! It's an urban night-scape photographer's dream.
No baseball fan credential is complete without making the pilgrimage to Wrigley Field.
The view of the downtown loop as we made the stroll towards Soldier Field.
Chicago is so picturesque it's nearly unfair.
The clouds made this view even more perfect. What beauty.
The Buckingham Fountain located in Grant Park, one of the largest water fountains on the planet.
High-rise condos doesn't look/get better than these.
A cross-sectional view of Chicago from US Cellular Field. We were there attending a Chicago White Sox baseball game.
I took this shot at the same spot as previous, only this time the baseball game is over and it's well into the night. Oh Chicago you gorgeous thing.
Photos from Chicago, the beautiful city of Gotham.


"Laparoscopy for abdominal emergencies: evidence-based guidelines of th" by Stefan Sauerland, Ferdinando Agresta et al.
BACKGROUND: Emergency laparoscopic exploration can be used to identify the causative pathology of acute abdominal pain. Laparoscopic surgery also allows treatment of many intraabdominal disorders. This report was prepared to describe the effectiveness of laparoscopic surgery compared to laparotomy or nonoperative treatment.
METHODS: A panel of European experts in abdominal and gynecological surgery was assembled and participated in a consensus conference using Delphi methods. The aim was to develop evidence-based recommendations for the most common diseases that may cause acute abdominal pain.
RECOMMENDATIONS: Laparoscopic surgery was found to be clearly superior for patients with a presumable diagnosis of perforated peptic ulcer, acute cholecystitis, appendicitis, or pelvic inflammatory disease. In the emergency setting, laparoscopy is of unclear or limited value if adhesive bowel obstruction, acute diverticulitis, nonbiliary pancreatitis, hernia incarceration, or mesenteric ischemia are suspected. In stable patients with acute abdominal pain, noninvasive diagnostics should be fully exhausted before considering explorative surgery. However, diagnostic laparoscopy may be useful if no diagnosis can be found by conventional diagnostics. More clinical data are needed on the use of laparoscopy after blunt or penetrating trauma of the abdomen.
CONCLUSIONS: Due to diagnostic and therapeutic advantages, laparoscopic surgery is useful for the majority of conditions underlying acute abdominal pain, but noninvasive diagnostic aids should be exhausted first. Depending on symptom severity, laparoscopy should be advocated if routine diagnostic procedures have failed to yield results.
Sauerland, S., Agresta, F., Bergamaschi, R., Borzellino, G., Budzynski, A., Champault, G., … Neugebauer, E. A. M. (2006). Laparoscopy for abdominal emergencies: evidence-based guidelines of the European Association for Endoscopic Surgery. Surgical Endoscopy, 20(1), 14–29.