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New Marker for Triple-Negative Breast Cancer Shows Potential in Predicting Chemo Response
Anna Azvolinsky
Researchers have identified a marker of DNA damage that may be able to predict a patient's response to platinum-based chemotherapy agents such as cisplatin and carboplatin.
3D model of carboplatin (top) and cisplatin (bottom)
Platinum-based chemotherapy is widely used as systemic treatments for ovarian and lung cancers as well as other types of tumors. Unfortunately, there is no way to predict whether a patient will respond to chemotherapy.
The marker identified by researchers-telomeric allelic imbalance-has the potential to predict whether a patient with triple-negative breast cancer will respond to platinum-based chemotherapy.
The authors additionally found an inverse relationship between the level of telomere allelic imbalance and the tumor expression of BRCA1. The results, from a team at the Dana-Farber Cancer Institute in Boston, are published in Cancer Discovery, a journal of the American Association for Cancer Research.[1]
There are currently no targeted agents available for triple-negative breast cancer, a subtype of breast cancer that is a heterogeneous group of tumor types that expresses neither estrogen-receptor, progesterone-receptor, nor HER2. When discovered late, triple-negative breast cancer is typically aggressive and difficult to treat.
"We currently do not have any targeted therapies for patients with triple-negative breast cancer, so if these laboratory findings are confirmed and an assay is created to predict sensitivity to drugs that target defective DNA repair, it would be a major step forward," according to Andrea Richardson, MD, PhD, lead pathologist and assistant professor of medicine at the Dana-Farber Cancer Institute, and one of the study coauthors.
The Rationale and Results
The ability to repair DNA is one way to measure whether a particular tumor will be sensitive to chemotherapy agents. Tumor cells that have functional DNA-repair pathways will not accumulate DNA damage caused by chemotherapy to the same extent as cells that have impaired DNA-repair function.
The authors looked for genomic signatures of defective DNA repair in tissue culture and tumor cells and correlated the signatures to platinum chemotherapy sensitivity. They found that allelic imbalances near the ends of chromosomes, called telomeres, could predict sensitivity to cisplatin both in vitro and in primary tissue from patients with triple-negative breast cancer and serous ovarian cancer. These accumulated telomoric imbalances are likely an indication of impaired DNA-repair function, according to the authors.
The telomere allelic imbalance, "a genomic measure of unfaithfully repaired DNA," could identify cancer patients that are more likely to benefit from treatments that take advantage of a tumor cell's defective DNA repair, concluded the authors. Allelic imbalances in general are likely due to improper DNA double-stranded break repair during the replication cycle of tumor cells. Subtelomeric and telomeric regions are known sites in the genome that are more difficult to replicate, where single and double-stranded breaks are more likely to form.
The research also showed an inverse relationship between telomere allelic imbalance and BRCA1 expression in triple-negative breast cancer and serous ovarian cancers with no BRCA1 or BRCA2 mutations. Mutations in the BRCA genes cause defects in DNA repair. The protein products of these genes function in DNA repair, cell cycle checkpoints, and DNA replications. It is likely that lower BRCA1 activity contributes to impaired DNA repair, including telomere allelic imbalance.
The authors analyzed 2 clinical trials of women with triple-negative breast cancer in which the women were treated with cisplatin before surgery. The pathological response at the time of surgery was a way to assess the sensitivity of the tumor to platinum-based chemotherapy.
An assay to measure telomeric allelic imbalances is feasible, according to the authors. Formalin-fixed paraffin embedded tumor material can be readily used and algorithms can be used to measure the copy number and allelic imbalance in tumor cells-even in a low tumor cell sample.
1. Nicolai J. Birkbak, Zhigang C. Wang, Ji-Young Kim, et al. Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents. Cancer Discovery. 2012 Mar 22. [Epub ahead of print]
Triple-Negative Breast Cancer | Breast Cancer | Ovarian Cancer


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new york state senator
Todd Kaminsky
Chair of Environmental Conservation Committee
( D ) 9th Senate District
message senator
Kaminsky Statement Re: Signing Of Steven McDonald Memorial Highway Bill
(Rockville Centre, New York) -- Senator Todd Kaminsky released the following statement regarding the Governor's signing of a bill to name a portion of the Southern State Parkway in Nassau County the "Detective Steven McDonald Memorial Highway." (Chap.172)
"Few people possessed the courage and the capacity for forgiveness of Detective McDonald," said Senator Todd Kaminsky. "I consider it a great honor to have known him. A true hero, and Malverne resident, Steven embodied a grace that is, unfortunately, all too rare. Our children do not have to rely on superhero movies to learn about heroics -- they just need to learn about Detective McDonald."
Senator Kaminsky sponsored a resolution and bill, J.1963, honoring the life of Detective McDonald, and S6549, which both passed unanimously on June 7, 2017, in the presence of Detective McDonald's surviving family, including his wife, Mayor of Malverne, Patricia Ann Noris-McDonald, and son, NYPD Sgt. Conor McDonald, who visited Albany for the occasion.
Detective McDonald has been recognized as a national hero for his perseverance after gunshot wounds he received while serving as a member of the New York City Police Department left him paralyzed in July of 1986. His message of hope and forgiveness, most notably to the young man responsible for his wounds, continue to inspire people the world over.
Video of Senator Kaminsky's comments on the floor of the NYS Senate recognizing the McDonald Family and in support of the legislation can be viewed here. Photos attached.
Designates a portion of the state highway system in Nassau county as the "Detective Steven McDonald Memorial Highway"
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Le lac Agassiz était un immense lac proglaciaire occupant entre le  millénaire et le  la partie centrale du continent nord-américain. Postulée par William Keating en 1823, son origine glaciaire fut démontrée en 1879 par Warren Upham qui lui donna le nom du scientifique américano-suisse Louis Agassiz.

Histoire
Formé il y a  à , le lac couvrait une grande partie du Manitoba, la partie occidentale de l'Ontario, une partie du Minnesota, du Dakota du Nord et de la Saskatchewan. À son extension maximale, il mesurait plus de  de long sur plus  de large et atteignait une profondeur de 210 m. Il aurait couvert jusqu'à  km, soit 25 % de plus que la mer Caspienne actuelle.

Il y a , les glaciers reculèrent rapidement et le lac Agassiz rétrécit, mais couvrait encore les plaines au sud de la baie d'Hudson. Ses eaux ont commencé à déborder d'abord vers le Mississippi par l'intermédiaire de la rivière Minnesota, puis dans le fleuve Saint-Laurent. Soudainement, il y a environ , les eaux du lac se sont répandues dans la baie d'Hudson et, en quelques mois, presque tout le lac s'est vidé dans l'Atlantique Nord.

Certains chercheurs estiment que cet apport d'eau glaciaire a créé un refroidissement brutal à l'échelle mondiale, en diminuant la salinité de l'océan, contrariant ainsi la circulation thermohaline. Le Gulf Stream, qui réchauffe la façade orientale de l'océan Atlantique, aurait ainsi été contrarié, ce qui aurait engendré une baisse de température de 5 °C en Europe pour plusieurs siècles. Le rôle de la vidange du lac Agassiz dans ce refroidissement a cependant été minimisé, voire contesté.

Vestiges
Aujourd'hui, l'ancien lac a laissé quelques vestiges,
 le lac des Bois,
 le lac Manitoba,
 le lac Seul,
 le lac Winnipeg,
 le lac Winnipegosis ;

entre autres, mais aussi des vallées fertiles, comme celles de
 la rivière Rouge du Nord,
 la rivière Assiniboine,
 la rivière La Salle
 la rivière Seine.

Notes et références

Sources
  Pierre-André Bourque, Planète Terre : Le retrait des glaces wisconsiniennes, les Grands Lacs, la Mer de Champlain, et le fleuve Saint-Laurent

Articles connexes
 Glaciations quaternaires
 Inondations de Missoula
 Lac glaciaire Ojibway

Agassiz
Glaciologie
Inondation
Lac au Manitoba
Lac en Saskatchewan

Nommé en hommage à Louis Agassiz

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All About Yoga and the Civilisational Debate
Historian H G Rawlinson made a crucial observation in his study on Indian historical studies (1931) which not only continues to remain relevant in the current academic and civilisational discourse in India, but also seeks redress. "Under the system in vogue in most Indian universities," observed Rawlinson, "the student knows more about Julius Caesar or the Battle of Marathon than of Chandragupta or the teaching of Gautama. We employ lecturers to instruct our pupils in western ethics but we forget to encourage them to study the admirable sermons in stone of their own emperor Asoka, written as they were for the edification of the people at large. No student should be allowed to waste his time over Greek and Roman history, while remaining ignorant of what the Greek historians and the Chinese travellers have to tell him of his own country and her past."
It is perhaps this trait of wasting excessive time over Roman history that has led some "celebrated" Indian historians to argue that Yoga has a Greek or Roman origin or influence.
Interestingly, while some of our present day "ideologue historians" argue for a Greek origin of Yoga, the Indian or Bharatiya or Hindu or Vedic antiquity of yoga has been definitely established. For historians who seek to read and cite nothing beyond their own work and those of their ideological comrades, such findings have obviously escaped notice.
Veteran archaeologist B B Lal in his seminal work, The Sarasvati Flows On: the Continuity of Indian Culture (2002) and Michel Danino, in his exhaustive study, The Lost River: in the Trail of the Sarasvati (2010), have detailed origins of yoga and its continuum. Excavations at Harappan sites have thrown up several seals with figures seated in the "mulabandhasana". Danino observes that "a striking example from Harappa shows a man seated cross-legged with his hands joined in the traditional Indian namaste: an av erage Indian would be hard put to decide whether it was made 4,500 years ago or yesterday!"
But our historian-eminences hardly have time or possess the talent or inclination or training to look at the world the other way round—not search for Greece in India but rather look for India in Greece.
In an interesting study inspired by such a reversal of gaze, a forgotten oriental scholar E. Pococke did just that. In his study India in Greece: Truth In Mythology (1852), Pococke argued that India had in fact heavily influenced the evolution of Greek civilisation, culture and art. He confidently asserted that he has established that the "whole of Greece, from the era of the supposed god-ships of Poseidon and Zeus, down to the close of the Trojan war, as being Indian in language, sentiment, and religion, and in the arts of peace and war."
For various political reasons, Pococke's political patrons suppressed the work; it would certainly not serve their political strategy to generate a debate on the possibilities of a reverse colonisation.
Whether Pococke eventually succeeded in establishing his claim, or whether his historical study held ground is still open to debate, the circulation of his work would have undoubtedly been among the triggers that could have inspired us to reverse our gaze rather than imitate and regurgitate a certain line that only furthered theories of the mission-civilisatrice.
We were ready to, as Sri Aurobindo caustically noted, "make ourselves a sort of brown Englishmen, to throw our ancient culture into the dust-bin and put on the livery or uniform of the West".
The International Yoga Day on June 21 is an occasion to engage in a civilisational debate on India's contributions to the world and, more importantly, to throw off that shackling livery.
http://www.newindianexpress.com/magazine/voices/2015/jun/20/All-About-Yoga-and-the-Civilisational-Debate-772217.html


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A garment factory in Indonesia. The Apparel Impact Institute and Fashion for Good estimate that it will take a trillion dollars in global investment to decarbonize the industry.Photograph: Bloomberg/Getty Images
Alden Wicker
The Fashion Industry Could Reduce Emissions—if It Wanted To
It's common practice for apparel brands to hop from factory to factory in search of cost savings. Experts say this keeps companies hooked on fossil fuels.
The fashion industry is in the mood to commit lately.
In 2019, some of the largest fashion brands in the world put their names on science-based climate targets, saying they would reduce their greenhouse gas emissions 30 percent by 2030 in order to stay in line with a UN-endorsed pathway to keeping the climate from warming more than 1.5 degrees Celsius. Just a couple of years later, the Sustainable Apparel Coalition, which has over 130 brand members—including Amazon, Gap, H&M, Nike, and Under Armour—upped that target for its members to a 45 percent reduction in emissions by 2030. At the COP26 climate conference last week, 130 companies joined in an announcement that they would reach net-zero emissions no later than 2050.
But to reduce greenhouse gasses, fashion's climate fight hinges on another commitment: cleaner factories.
Forget swapping in energy-efficient light bulbs in retail stores—according to the World Resources Institute, 96 percent of a fashion brand's footprint is in its manufacturing supply chain. In other words, it's the factories (and to a lesser extent, farmers who grow cotton and raise sheep for wool and cows for leather) who will have to do the work so brands can reach these lofty, well-publicized goals.
Unfortunately, when it comes to factories, brands seem to have more commitment-phobia than a 24-year-old on Tinder.
"We're a migratory business," says Sanjeev Bahl, founder and chief executive of Saitex, the sustainable Vietnamese denim supplier. Like a digital nomad crypto bro, brands roam from factory to factory and country to country, looking for the facilities that can offer them the cheapest prices and the fastest turnaround.
During the pandemic, that fact became clear to the public. As the retail stores abruptly closed, brands and retailers ghosted their suppliers, breaking contracts, canceling orders, and asking for steep discounts or refusing to pay for orders that in some cases had already shipped. "You've seen what's happened pre- and post-Covid. Most factories, why would they invest [in low-carbon technology]?" Bahl says.
In fact, a study from The Climate Board released this month found no correlation between bold climate commitments from brands and actual carbon reductions. In order for the fashion industry to truly decarbonize, brands are going to have to stop being such flakes.
The fashion and climate experts I spoke to largely believe that the technology exists to halve the fashion industry's emissions in 10 years.
There are four big levers apparel retailers could pull to get there. One is switching factories from coal to renewable energy. Solar and wind are well-established and cost-effective sources. Rooftop solar alone can handle 10 to 20 percent of a factory's energy needs, and the rest can be bought from an offsite solar or wind farm.
"The barriers are mainly policy," says Michael Sadowski, a research consultant with WRI. As he and others pointed out, it's difficult to decarbonize when most fashion is made in countries that run on coal. For example, Vietnam, where a large portion of the world's fashion is made, doesn't allow businesses to purchase renewable energy generated offsite. But that could change as early as this year, with the Vietnamese government poised to approve a pilot power purchase agreement program.
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Figuring out how to decarbonize thermal energy—used for heating water and making steam—will be more difficult. According to AII's and Fashion for Good's forthcoming report, "Unlocking the Trillion-Dollar Fashion Decarbonisation Opportunity," just over half of fashion's manufacturing emissions come from the dyeing and finishing of material—called wet processing—and almost all of the industrial boilers that produce steam and hot water run on coal. The rest run on fossil gas. The United Nations Fashion Charter for Climate Action committed to stopping the use of coal by 2025, but Nike is the only brand that has taken real action in this area, by helping its footwear suppliers electrify all of their boilers.
Gary Cook, the global climate campaigns director at the advocacy organization Stand.Earth, says this particular puzzle could be solved by electrifying boilers, installing solar thermal systems, or using hydrogen made from renewable resources. These are all expensive propositions, though an H&M representative said by email that the company plans to test solar thermal in the near future. The denim supplier Saitex, which made its own commitment to becoming climate neutral by 2025, built a new boiler that burns industrial waste sludge as its fuel source. "It's expensive; it has a seven-year break-even point," Bahl says.
Some dry-processing technologies have also been invented for dyeing and finishing textiles—plasma, supercritical CO2, foam, or ultrasonic technology—that would drastically reduce the industry's reliance on boilers.
The second big carbon-saving switch for the fashion industry would be to move away from materials like polyester, nylon, and others derived from fossil fuels. Many of these alternative materials are exciting. Last month, we reported on AirCarbon, a carbon-negative leather-like material. There's also Fairbrics, which creates polyester out of captured carbon; Full Cycle, which creates bio-polymers out of organic waste; and Bloom by Algix, which uses algae harvested from lakes to create synthetic rubber.
The third lever would be shipping products across the world on boats using clean fuel. In this area, hydrogen fuel is showing promise as a more eco-friendly alternative to the dirty diesel ships currently use, and in October a small consortium of brands committed to using zero-carbon shipping fuels by 2040. (There are those commitments again.)
The fourth—powerful—way to reduce the industry's impact: Make less stuff. Brands of all sorts are experimenting with rental, repair, and resale services that promise to shift some of their revenue away from manufacturing goods in favor of providing fashion services.
So in theory, fashion could reach its ambitious targets. But when I asked experts if the fashion industry is on track to hit its 2030 goal, all I heard was, "No."
"The reality is, whether the technology is there or not, the demand doesn't exist," says Kurt Kipka, vice president at the Apparel Impact Institute, which was founded to help brands do this exact decarbonization work. Brands don't so much demand as "invite" and "encourage" a select few of their biggest suppliers to set emission reduction targets.
"I mean, I come from a climate background. So I really want 45 percent," says Vidhura Ralapanawe, the executive vice president for sustainability and innovation at Epic Group, a large Hong Kong-based apparel manufacturer. "I really would like to see more than a 45 percent reduction. But I don't see the conversations happening." He should know—before he worked in fashion, Ralapanawe was an independent climate researcher at Columbia University's Earth Institute, and he now sits on Sustainable Apparel Coalition's board. "You talk about the technology side. We haven't talked about the business model. Where are the incentives? How is the risk and reward shared between different partners in the value chain? We don't have a discourse around this, apart from, you know, standard catchphrases."
'Like Falling Off a Log'
Long before any of these whizbang technologies get implemented, emissions could be cut just by making other efficiency improvements, like upgrading machinery and insulating steam vents. It's not very sexy, but it's effective and—crucially—affordable.
"There are production efficiency improvements that are like falling off a log," says Linda Greer, global fellow at the Institute for Public and Environmental Affairs, a Chinese environmental research nonprofit. In 2007, she founded the National Resource Defense Council's Clean by Design program, which morphed into AII's program.
Factory owners are by and large happy to invest in efficiency improvements as long as they get a little help from brands with planning and logistics. "These folks are business owners, right? They're gonna save money," says Sadowski.
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In 2019, Adidas released a very detailed guidebook for factories seeking to reduce their energy usage, water usage, and waste. But few other brands have even made moves to help their manufacturing partners with these minor, affordable upgrades. According to a recent report from Planet Tracker, the average cost of lowering the footprint for a wet processing facility, where textiles are finished and dyed, is $455,000. Even though the factory would earn back that amount in less than two years, facilities have dragged their feet on such upgrades because they lack the know-how and access to bank loans.
"They can't even do the little stuff," says Greer of fashion brands. "If we saw an industry that was harvesting the low hanging fruit everywhere they could get it and then they were hitting the brick wall when it came to a technological barrier, then I would feel sympathetic." She would like to see fashion brands map out their supply chain, help suppliers accurately measure their emissions and energy usage, and then choose suppliers based on their environmental performance. "This is not rocket science at all," Greer says. "I mean, this is like, get a few sharp summer interns and pull them in for three months and have them go through this."
Instead, the fashion industry has been harping on the Circular Economy, a concept in which materials are recycled endlessly through the supply chain. You see gestures toward this in capsule collections of jeans made with 20 percent recycled cotton and the proliferation of products made with recycled water bottles. Here's the thing about that, though: In the short term, polyester made from recycled water bottles does have a lower carbon footprint. But once it's made into fashion, it can never be recycled again—the next stop for such apparel is the trash. Less than 1 percent of all clothing is currently recycled into new clothing. And nobody has actually done the calculations to confirm whether recycling polyester into polyester would lower our emissions—it's a pretty energy-intensive process.
Greer says these initiatives are like the limited-edition, heavily marketed capsule collections common in the fashion industry: "meant to catch your eye, and sort of cool and a little glittery. But if you really look hard at it, it's not gonna come to scale."
That's not to say absolutely nothing is being done. Both Stand.Earth and IPE rank companies on their climate commitments and actions—the latter focusing only on pollution in China—and a few brands consistently come out on top: Nike, Levi's, Adidas, Puma, and H&M. They're setting targets, calculating their emissions, and starting on projects to reduce them. Some of these companies are writing letters to the governments of coal-burning countries and saying they might move their manufacturing elsewhere if the countries don't modernize their grids.
But each brand in this tiny cabal gets at most a C+ from Stand.Earth for its efforts, and these companies represent no more than a couple percentage points of the world's volume of fashion being made. Katrin Ley, managing director at the Amsterdam-based accelerator Fashion for Good, says her team once did a back-of-the-envelope calculation that showed the top 200 global fashion brands account for less than 10 percent of the total volume of fashion being sold globally. "You have the Sheins of this world, you have lots of gray market non-brands that are also quite dominating," she says. Other big brands like DKNY and Roxy haven't taken any actions or made any pledges that indicate they think climate is even an issue. (They did not respond to requests for comment.)
Meanwhile, fashion's production is back up to pre-pandemic levels, and the push for newness has only increased as brands rush to catch up with the ultra-fast, ultra-cheap drops of the Chinese behemoth Shein. All those rental and repair programs being launched haven't made a dent.
"We have to reduce consumption," says Ralapanawe. "Even if we reduce the carbon intensity of individual products, just the fact that the number of products that we are going to make continues to increase, we will keep pulling up the emissions."
Who Will Pay for It?
The Apparel Impact Institute and Fashion for Good estimate that it will take a trillion dollars in global investment to decarbonize the industry. Their new report calls it an investment "opportunity," but brands are not exactly climbing over each other to get involved.
"Financial support? No, zero," Bahl says. "It's not the practice that brands give financial support to factories. The suppliers have to figure it out themselves."
The exception is H&M, which finances early stage innovation with investments in various innovative materials. An H&M representative also told WIRED that the company will soon start investing in bigger infrastructure projects and offer low-cost loans to suppliers. But Perkins of AII sees the money (hopefully) coming from multiple other places: traditional banks, development banks like the IFC and World Bank, private equity, and a little bit of philanthropy.
"The brands don't have the assets available to underwrite lending to all the facilities; that is the role of the bank," Perkins says. "What they can offer is stability around the relationship."
Ah, stability. If brands really wanted to do this, they would commit to long-term purchasing contracts with suppliers to support them throughout the seven-year-plus payback period when they invest in low-carbon technology. Banks know that garment manufacturing is risky, that an important brand can switch factories just like that the next year. A brand committing to a supplier relationship would ease bankers' minds. But while everyone agrees on this crucial step, nobody could point me to any official commitments from brands.
Kipka and Perkins pointed to Target's commitment (with AII) that 80 percent of its facilities have science-based emissions reduction targets; Walmart's recent closing of a green bond, which it says will fund sustainability projects in its operations and supply chain; and Puma's sustainability-related revolving credit. Levi's comes close by connecting its best-performing suppliers to IFC financing. These programs hint that brands are getting serious about helping their manufacturing partners modernize to meet climate targets. "We're feeling the acceleration," Perkins says.
But these scattershot incentives are not the paradigm shift we need. The answer seems to lie with governments in the countries that manufacture and buy fashion recognizing how important the fashion industry is to their climate goals and regulating accordingly. "You cannot leave it up to voluntary commitments," Ley says. "You need to have a stronger legislative framework that really levels the playing field." For what it's worth, H&M, Levi's, and Puma have indicated that they're open to new legislation on this, whether from nations that buy the clothing, nations that produce the clothing, or both.
"The simple answer is legislation, or the lack of it, and taxation, or the lack of it," Bahl says. "I've seen a lot of commitments made and not delivered. Even if you make a commitment, there's no real threat if you don't fulfill the commitments. You're not going to get sued—who's going to hold you accountable?"
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In the Hungarian National Gallery in Budapest there are two corresponding exhibitions, showcased almost simultaneously. Their juxtaposition makes a peculiar dialogue between the artworks of two painters of Jewish descent. They met only once, in Paris in 1937, for a brief conversation. Marc Chagall lived on and created for many years, while his interlocutor, the Hungarian painter Imre Ámos, died in the Second World War just a few years later. The exhibitions reveal how deeply ingrained in tradition and religion both artists were, and show the paths of their artistic development, which sometimes crossed and sometimes led separate tracks. Almost 40 of Chagall's paintings have been brought from France for the exhibition. Among them, an extraordinary piece – an enormous canvass titled Life (La vie), which left its museum in the southern town of Saint‑Paul de Vence for the very first time. All paintings by the Hungarian author come from the Hungarian National Gallery.


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Jennifer Robson & local author Laurie Petrou close out Grimsby Author Series 2018
Posted on April 26, 2018 April 26, 2018 by grimsbylibrary
Last Monday night we wrapped up the 2017-18 Grimsby Author Series with an inspiring evening featuring Grimsby's own buzzworthy literary talent Laurie Petrou, and bestselling historical fiction author Jennifer Robson. It was the last event of the regular season, but it was actually a night full of firsts for the series. It was our first time welcoming both authors to our stage, it was Laurie Petrou's first ever public reading of her first published novel, and she just happened to be our first ever local Grimsby author, too. Oh, and it was our first time ever having a craft beer vendor attend! As most of you know we usually have a local Niagara winery on hand to supply libations, but this Monday it was Bush Pilot Brewing Company who kept us refreshed. On one of the first more reasonably warm days of the year, it was lovely to have some ice cold Pengo Pally Saisons (brewed with Arctic herbs) for their inaugural night with us, and we couldn't think of a better way to mix things up!
Laurie Petrou
Local hearts were glowing with pride as Grimsby author Laurie Petrou took the stage for her debut Author Series appearance and first ever book reading. Having attended our events as a guest for years, it was only fitting that her first one should be with us! Laurie is one of the Niagara Region's most exciting up-and-coming talents and we are so privileged to have her living and working right here in our hometown. She was the winner of the Half the World Global Literati prize in 2016 for her at-the-time unpublished book. Earlier this year it was snapped up and published by Harper Collins Canada. The team at the Grimsby Library and Author Series couldn't be more delighted to support this local author with the release of her first novel.
Sister of Mine is a riveting and suspenseful family drama that has literary-thriller fans standing at attention. It starts with a shocking murder, but it's not a "whodunit". It's a "what happens next" tale. The substance of the story is really in the aftermath. What happens in the days, months and years after the event? How do the people involved keep such a terrible and damaging secret? How do our lives get twisted when our deepest bonds are pushed to their limits? Exploring the complexities of loyalty and sisterhood by reveal snapshots into the characters' past. Laurie writes a deeply compelling story that expertly awakens all five senses. From the first sentence, Sister of Mine hooks the reader and does not let go. It is a riveting page-turner from start to finish and is the work of a new master storyteller.
Jennifer Robson
Jennifer Robson's internationally bestselling books have been enduring favourites here at the Grimsby Library, and we were so happy to have the chance to welcome her to the Grimsby Author Series for the first time! An academic at heart, Jennifer has a passion for researching the past, and has an innate ability to make history come alive through perspectives that often get lost in time. It is the stories of women that interest her, and exploring what their lives were like against the backdrop of some of history's most exciting, dramatic and important moments. Her latest book Goodnight from London, accomplishes this objective perfectly.
The book follows Ruby Sutton, a reporter for an American magazine in 1940's wartime, who gets the chance to fly to London and report on the war first hand. Women reporting on the ground in this way was almost unheard of at the time, but this character exemplifies the type of person Jennifer loves to capture in her books. It is all the more poignant as the story of the main character is inspired by her own grandmother who was a reporter. Jennifer Robson knows how to deliver the goods, and her accurate portrayal of London during the Blitz, the aftermath of the bombings, and life in a besieged city told through the eyes of ordinary people is unmatched.
Door prizes were raffled off at the end of the night as well which included fabulous items from our sponsors Cole's Florists, Objects to Desire, Stacy Heidman of Steeped Tea, Elipsis Day Spa, Special Effects Art Shoppe, Theatre Aquarius, and Hamilton Philharmonic Orchestra. A big thank you to all of these contributors, and to The Peanut Mill, Forks Road Pottery and Bush Pilot Brewing Company for providing our guest speakers with their wonderful gifts.
Both authors answered a ton of questions from the audience after their talks from the audience and stayed after the raffles were drawn to sign copies of their books for an impressive lineup of fans. We'd like to send out a huge thank you to both Laurie and Jennifer for attending and closing out our sweet 16th season with style. Seeing as they both have new books in the works, we hope to see both cross our stage again soon!
Did you miss out on your chance to attend the regular season of the Grimsby Author Series? Well, you still have one more chance this June to go to an event! Check it out below:
At the Library w/ Paula McLain and Katherine Ashenburg
Doors: 6:30 PM / Event: 7 PM
Tickets: $20 each
The Grimsby Public Library is welcoming two award-winning, critically acclaimed authors late this spring for a special event of the Grimsby Author Series. Paula McLain and Katherine will be here on Friday, June 1 (doors at 6:30 PM) to speak about their latest works and sign books for fans. Snacks and a wine tasting from Peller Estates will be provided. Tickets are just $20 each, and are on sale now at the Library, or you can buy tickets online.
Buy tickets for our 3 Fall events this August. These will be held in September, October and November. Fall packages are $75 each.
No more full-season packages! The series will be split into 2 parts instead: Fall 2018 and Spring 2019. The lineup for the Spring 2019 season will be announced in the fall, tickets will go on sale before Christmas, and the events will be held in March, April and May. This allows us to invite authors who have new books being released in the spring, while avoiding the bad weather months of January and February.
Please contact the Library at 905-945-5142 for more info.
Our sponsors, benefactors and volunteers
Last but certainly not least we would like to thank all of our awesome volunteers, sponsors and benefactors for another amazing season! We 100% could not do it without you, and are so appreciative of all of our support and generosity throughout the years. We look forward to next season and working with you again!
← Meridian Comic Book Day at Grimsby Library in pictures
Phelps Homes Building Literacy Fair 2018 at the Library coming up June 8 →


Germination Test, Viability | AMM Seed Testing, Inc.
The laboratory germination test determines the germination potential of a seed lot by growing the seeds under carefully controlled conditions. Temperature, moisture, and light are all maintained at the optimum levels for germination. After the prescribed growth period, the seedlings are evaluated and the results are reported as percentage of germination. Only healthy seedlings that have all critical structures sufficiently developed and intact are counted as normal.
Seeds are tested in the lab using artificial growth media, such as germination paper, blotter paper, and/or creped cellulose paper. Sand or soil mixtures can also be used. These materials eliminate most of the variables caused by natural soils, such as organic matter, microbes, fungi, and other factors. It also allows for easier examination of the seedling structures.
Although crops are not usually grown under absolutely perfect conditions in the field or greenhouse, testing seeds under optimum conditions shows the maximum germination potential of a seed lot. It is also the best way to obtain consistent results which can be duplicated within the laboratory, or between different laboratories. It establishes a consistent value for the seed lot.


text:
// Copyright 2021 The Chromium Authors
// Use of this source code is governed by a BSD-style license that can be
// found in the LICENSE file.

/**
 * Tests for the <emoji-picker> Polymer component.
 */

GEN_INCLUDE([
  '//chrome/test/data/webui/polymer_browser_test_base.js',
]);

GEN('#include "ash/constants/ash_features.h"');
GEN('#include "content/public/test/browser_test.h"');

// This file bootstraps the other tests written in Javascript.
class EmojiPickerBrowserTest extends PolymerTest {
  /** @override */
  get browsePreload() {
    return 'chrome://emoji-picker';
  }

  /** @override */
  get featureList() {
    return {enabled: ['chromeos::features::kImeSystemEmojiPickerClipboard']};
  }
}

// Tests behaviour of <emoji-picker> component.
var EmojiPickerMainTest = class extends EmojiPickerBrowserTest {
  /** @override */
  get browsePreload() {
    return 'chrome://emoji-picker/test_loader.html?module=' +
        'chromeos/emoji_picker/emoji_picker_test.js&host=test';
  }
};

TEST_F('EmojiPickerMainTest', 'All', function() {
  mocha.run();
});

// Tests functionality of recently used storage.
var EmojiPickerStoreTest = class extends EmojiPickerBrowserTest {
  /** @override */
  get browsePreload() {
    return 'chrome://emoji-picker/test_loader.html?module=' +
        'chromeos/emoji_picker/emoji_picker_store_test.js&host=test';
  }
};

// TODO(https://crbug.com/1179762): Re-enable once flakiness is fixed.
TEST_F('EmojiPickerStoreTest', 'DISABLED_All', function() {
  mocha.run();
});

var EmojiPickerExtensionBrowserTest = class extends PolymerTest {
  /** @override */
  get featureList() {
    return {enabled: ['chromeos::features::kImeSystemEmojiPickerExtension']};
  }

  /** @override */
  get browsePreload() {
    return 'chrome://emoji-picker/test_loader.html?module=' +
        'chromeos/emoji_picker/emoji_picker_extension_test.js&host=test';
  }
};

TEST_F('EmojiPickerExtensionBrowserTest', 'All', function() {
  mocha.run();
});

var EmojiPickerExtensionEmojiTest = class extends PolymerTest {
  /** @override */
  get featureList() {
    return {enabled: ['chromeos::features::kImeSystemEmojiPickerExtension']};
  }

  /** @override */
  get browsePreload() {
    return 'chrome://emoji-picker/test_loader.html?module=' +
        'chromeos/emoji_picker/emoji_picker_extension_emoji_test.js&host=test';
  }
};

TEST_F('EmojiPickerExtensionEmojiTest', 'All', function() {
  mocha.run();
});

var EmojiPickerExtensionSymbolTest = class extends PolymerTest {
  /** @override */
  get featureList() {
    return {enabled: ['chromeos::features::kImeSystemEmojiPickerExtension']};
  }

  /** @override */
  get browsePreload() {
    return 'chrome://emoji-picker/test_loader.html?module=' +
        'chromeos/emoji_picker/emoji_picker_extension_symbol_test.js&host=test';
  }
};

TEST_F('EmojiPickerExtensionSymbolTest', 'All', function() {
  mocha.run();
});

var EmojiPickerExtensionEmoticonTest = class extends PolymerTest {
  /** @override */
  get featureList() {
    return {enabled: ['chromeos::features::kImeSystemEmojiPickerExtension']};
  }

  /** @override */
  get browsePreload() {
    return 'chrome://emoji-picker/test_loader.html?module=chromeos/' +
        'emoji_picker/emoji_picker_extension_emoticon_test.js&host=test';
  }
};

TEST_F('EmojiPickerExtensionEmoticonTest', 'All', function() {
  mocha.run();
});

var EmojiPickerExtensionSearchTest = class extends PolymerTest {
  /** @override */
  get featureList() {
    return {enabled: ['chromeos::features::kImeSystemEmojiPickerExtension']};
  }

  /** @override */
  get browsePreload() {
    return 'chrome://emoji-picker/test_loader.html?module=' +
        'chromeos/emoji_picker/emoji_picker_search_test.js&host=test';
  }
};

TEST_F('EmojiPickerExtensionSearchTest', 'All', function() {
  mocha.run();
});

var EmojiPickerTrieTest = class extends PolymerTest {
  /** @override */
  get featureList() {
    return {
      enabled: ['chromeos::features::kImeSystemEmojiPickerSearchExtension'],
    };
  }
  /** @override */
  get browsePreload() {
    return 'chrome://emoji-picker/test_loader.html?module=' +
        'chromeos/emoji_picker/emoji_picker_trie_test.js&host=test';
  }
};

TEST_F('EmojiPickerTrieTest', 'All', function() {
  mocha.run();
});

var EmojiPickerPrefixSearchTest =
    class extends EmojiPickerExtensionBrowserTest {
  /** @override */
  get browsePreload() {
    return 'chrome://emoji-picker/test_loader.html?module=' +
        'chromeos/emoji_picker/emoji_picker_prefix_search_test.js&host=test';
  }
};

TEST_F('EmojiPickerPrefixSearchTest', 'All', function() {
  mocha.run();
});

redpajama_set_name: RedPajamaGithub


text:
Home / Travel Guides / Vietnam / How to Spend 2 Weeks in Vietnam Sample Itinerary
How to Spend 2 Weeks in Vietnam Sample Itinerary
Surrounded by Laos, Cambodia and China is the country of Vietnam, an amazing destination in the heart of Southeast Asia. Ravaged by war multiple times, Vietnam is a country with a rich history as well as a past filled with turbulence. Despite that, however, it is a welcoming atmosphere where visitors can mingle with locals and experience everything from city life in places like Ho Chi Minh to rural life in smaller villages.
With this itinerary in hand, you can expect to get to know the best of Vietnam in 2 weeks time, including its biggest cities and landmarks, as well as see some of the most scenic views by train.
1. Ho Chi Minh City (3 nights)[SEE MAP]
Arguably the best place to start a trip through Vietnam is in Ho Chi Minh City, the former capital that is still commonly referred to as Saigon. After American troops left the city in 1975 during the Vietnam War, Ho Chi Minh City shrank in size, since many of the residents fled. In the decades since, the city has grown again, becoming the economic center of Vietnam. There are an endless number of ways to pass the time here, but some of the truly must-see attractions in Ho Chi Minh City include the Reunification Palace, the French colonial City Hall, the Notre-Dam Cathedral and the Saigon Skydeck in the Bitexco Financial Tower, which lets you enjoy breathtaking views over the expansive city below.
See also: Top Saigon Attractions
2. Cu Chi Tunnels (day trip from HCMC)[SEE MAP]
Exploring the Cu Chi Tunnels is an amazing experience and a great day trip from Ho Chi Minh City that helps to sum up the incredible hardship of war as well as the tenacity and strength of the Vietnamese people. This elaborate system of more than 240 km (150 miles) of tunnels was dug exclusively using bare hand and simple tools throughout the French occupation and later the Vietnam War. The residents of Cu Chi lived in these tunnels, which also gave American soldiers a wartime advantage. Today, guided tours are available that depart from Ho Chi Minh City and explore the tunnels of both Ben Dinh and Ben Duoc.
3. Nha Trang (2 nights)[SEE MAP]
Although Vietnam is closely associated with its recent wars, it is also home to beautiful beaches, some of which are found in Nha Trang. This coastal resort destination is the ultimate place to relax and unwind for a few days of your 2 weeks in Vietnam, and it boasts all kinds of outdoor recreation opportunities. In addition to soaking up the sun from the sand of Bai Dai Beach, you can admire the Yang Bay Waterfalls, hike to the Thap Ba Hot Springs and Mud Baths, take a sailing lesson, go surfing, rent a bicycle or go scuba diving.
4. Hoi An (2 nights)[SEE MAP]
If you're interested in the ancient history of Vietnam, its architecture and its people, then Hoi An is an amazing place to visit. Hoi An was once a port city in the Cham Kingdom, and it dates back to more than 2,000 years ago. The Old Town of Hoi An is the hub for historic landmarks, museums, and architecture, so don't miss out on seeing places like the Japanese Covered Bridge's Pagoda, the Quan Cong Temple, the Hoi An Museum of History and Culture and the Phung Hung House, which has been continuously inhabited by more than eight generations of the same family. Hoi An is a popular place to get custom shoes or suits made, so head to Hoang Dieu Street if that's what you're looking for as a souvenir.
See also: Top Tourist Attractions in Hoi An
5. Hue (1 night)[SEE MAP]
Hue was once the imperial capital of Vietnam, making it the home of several emperors in the 19th and early 20th centuries. On the banks of the Perfume River, Hue boasts countless architectural masterpieces and museums devoted to the history of the country. Start in the Imperial Citadel, or Dai Noi, to tour the sprawling complex made up of the Thái Hòa Palace, where the emperors had their coronations, the Trường Sanh Residence, a royal palace, and the Hue Jungle Crevice, a sad monument to the ravages of wartime. You can also tour several imperial tombs as well as a number of hot springs just outside the city limits.
See also: Top Hue Attractions
Hue to Hanoi: Overnight Train Journey
flickr/calflier001
There are plenty of ways to get around in Vietnam, but one of the best is the overnight sleeper train. The perfect journey is the one between Hanoi and Hue, which takes about 14 hours. The tickets are affordable whether you opt for a private compartment or a four-person bunk compartment, and the experience is a wonderful alternative to flying. Enjoy a dinner in Hue and then climb aboard, make a few friends and tuck yourself into bed. In the morning, sit by the window and watch the sunrise over the landscape of Vietnam before changing in the bathroom and heading out for a day of exploration in Hanoi.
6. Hanoi (1 night)[SEE MAP]
As Vietnam's capital, there is no end to the things worth seeing, doing and exploring in Hanoi. For your first night in the city, start by checking out two of the biggest museums: the Ho Chi Minh Museum and the Ho Chi Minh Mausoleum. These two landmarks are major attractions for visitors as well as the Vietnamese people. Then, make time to tour some of the many beautiful temples in Hanoi, which might include the Temple of Literature, which is more than 1,000 years old, the Ngoc Son Temple and the Bach Ma Temple.
Accommodation: Where to Stay in Hanoi
See also: Top Hanoi Attractions
7. Halong Bay (2 nights)[SEE MAP]
After your first night in Hanoi, head to Halong Bay for an escape from the hustle and bustle of the city. Ha Long Bay is perhaps the most popular destination in the country for those in search of breathtaking scenery, and it is easy to see why. Multiple islands pop out of the clear blue water, creating an almost other-worldly landscape. The best way to spend time in Halong Bay is to embark on an overnight cruise. These cruises include accommodation, food and drinks, and they will bring you to see iconic islands in the bay like Ban Sen and Cat Ba.
Hanoi (2 nights)
After soaking in the ethereal beauty of Halong Bay, head back to Hanoi to round out your stay in Vietnam. Hanoi is home to several wartime landmarks from the 1960s and 1970s, and you may be interested in seeing the Hoa Lo Prison, often referred to as the Hanoi Hilton, the Army Museum and the Downed Aircraft Memorial. Although Hanoi is a bustling city, there also plenty of green spaces like Hoan Kiem Lake and the Lenin Statue & Park. To experience some of Hanoi's heritage and artistic culture, make time for a traditional puppet show at the Thang Long Water Puppet Theater or a live performance of the Golden Bell Show.
Day 1: Arrive in Ho Chi Minh City, sleep in HCMC
Day 2: Explore Ho Chi Minh, sleep in HCMC
Day 3: Take Cu Chi Tunnels or Mekong Delta day trip, sleep in HCMC
Day 4: To Nha Trang, sleep in Nha Trang
Day 5: Explore Nha Trang, sleep in Nha Trang
Day 6: To Hoi An via Da Nang, sleep in Hoi An
Day 7: Explore Hoi An, sleep in Hoi An
Day 8: To Hue, sleep in Hue
Day 9: Explore Hue, overnight train to Hanoi, sleep in train
Day 10: Explore Hanoi, sleep in Hanoi
Day 11: To Halong Bay, take Halong Bay Cruise, sleep on boat
Day 12: Continue Halong Bay cruise, return to Hanoi
Day 14: Fly home
11 Best Things to do in Halong Bay, Vietnam
12 Best Places to Visit in Vietnam
25 Top Tourist Attractions in Vietnam
10 Days in Vietnam Tour: From South to North
10 Best Things to do in Sapa, Vietnam
Are These the Most Underrated Destinations in Vietnam?
10 Top Attractions in Ho Chi Minh City
12 Best Things to do in Nha Trang, Vietnam
10 Best Beaches in Vietnam
17 Best Cities to Visit in Vietnam
10 Best Vietnam Luxury Resorts


Do you ever wonder if what you're eating at local restaurants or the unmarked meat at a butcher shop is truly halal and how you can ask to find out where things are really coming from? Check out my latest video update where I address this issue and hopefully answer those questions with tips on how you can find out everything you need to know. I'd love your comments at the end of this post.
You can see more videos on the My Halal Kitchen You Tube channel.
Previous articleIs There a Link Between Sugar & Disease?


Christians, including many ministers, continue to perceive the "Church" as all Christians worldwide regardless of denomination or grouping. This is not true and never has been true. It should be obvious. The Lord teaches that there are actually two groups, not one. The first group is composed of all real Christians who have bowed the knee to the Lord Jesus and confess His Name, the Name above every name. The members of this group comprise His Community on the planet. This has always been the case from the beginning and has never changed.
The other group is comprised of Christians in name only. These are largely cultural Christians who have never surrendered to the Lord Jesus. They have never repented properly of their sins. They have never been born again as the Lord Jesus said all believers must be. They have never been filled with the Holy Spirit. Their hearts have never been circumcised unto God. They continue to live in the flesh and honor human leaders and human institutions rather than honor the Lord Jesus and His one Community or Kingdom.
There is only one King. There is only one Lord and Savior. Only one Man went to the cross and paid for our sins with His one and only perfect sacrifice. After He rose from the dead He said He possessed all authority in both heaven and earth. Those who follow Him are completely distinct from the people of this world. Those who do not follow Him but refer to themselves as Christians or are perceived as some form of Christian do not qualify. There is only one door into this Community and the Lord Jesus is that Door.
Thus, Christians should stop referring to the "Church" as a universal monolith made up of all "Christians." The real Church, His Community, is the one in which each member follows Him and obeys Him. It is in great shape and is doing great things in the earth. Massive progress has been made in this Community since the first century AD and great progress continues onward. The Lord is getting it done!
Therefore, there is Real Christianity and there is Unreal Christianity. There is the real Church and there is the fake church. The fake church is multi-denominational and is beset with multitudinous non-relatable factions. The real Church follows and obeys to the best of its ability the full curriculum of the Lord Jesus. The members thereof believe in all of His teachings. They do not pick and choose. They do not put one teaching above another or form a denomination based on particular teachings to the detriment of others.
Posted on September 23, 2018, in Current Events and tagged America, Book of Acts, Christianity, Church, Deception, Hidden Agenda, Lord Jesus, Real Christianity, The Great Awakening, Unreal Christianity. Bookmark the permalink.	5 Comments.
Amen!! The Bible says there are to be no divisions! I believe that to mean that not all denominations are Christian! Please correct me if that perception is wrong! Great post!!!
The parable about the weeds sown among the grain by the devil… We who truly believe can already see the holy angels remove the weeds from the harvest fields. And we know where they end up. True honesty glows with Heaven's Light. Thank you.
There will be separation between the real and the look-alikes, whether sheep and goats or real wheat and wild wheat. The Lord knows those who are His own.


text:
Browse Now . . .
Technology is an applied science, i.e., it translates the discoveries of theoretical science into practical application to man's life. As such, technology is not the first step in the development of a given body of knowledge, but the last; it is not the most difficult step, but it is the ultimate step, the implicit purpose, of man's quest for knowledge.
The Objectivist , Sept. 1969, 9
Nothing can raise a country's productivity except technology, and technology is the final product of a complex of sciences (including philosophy), each of them kept alive and moving by the achievements of a few independent minds.
"The Moratorium on Brains,"
The Ayn Rand Letter , I, 3, 5
The enemies of the Industrial Revolution—its displaced persons—were of the kind that had fought human progress for centuries, by every means available. In the Middle Ages, their weapon was the fear of God. In the nineteenth century, they still invoked the fear of God—for instance, they opposed the use of anesthesia on the grounds that it defies God's will, since God intended men to suffer. When this weapon wore out, they invoked the will of the collective, the group, the tribe. But since this weapon has collapsed in their hands, they are now reduced, like cornered animals, to baring their teeth and their souls, and to proclaiming that man has no right to exist—by the divine will of inanimate matter.
The demand to "restrict" technology is the demand to restrict man's mind. It is nature—i.e., reality—that makes both these goals impossible to achieve. Technology can be destroyed, and the mind can be paralyzed, but neither can be restricted. Whenever and wherever such restrictions are attempted, it is the mind—not the state—that withers away.
"The Anti-Industrial Revolution,"
Return of the Primitive: The Anti-Industrial Revolution , 285
If you consider, not merely the length, but the kind of life men have to lead in the undeveloped parts of the world—"the quality of life," to borrow, with full meaning, the ecologists' meaningless catch phrase—if you consider the squalor, the misery, the helplessness, the fear, the unspeakably hard labor, the festering diseases, the plagues, the starvation, you will begin to appreciate the role of technology in man's existence.
Make no mistake about it: it is technology and progress that the nature-lovers are out to destroy. To quote again from the Newsweek survey: "What worries ecologists is that people now upset about the environment may ultimately look to technology to solve everything . . . ." This is repeated over and over again; technological solutions, they claim, will merely create new problems.
Whom and what are [the ecological crusaders] attacking? It is not the luxuries of the "idle rich," but the availability of "luxuries" to the broad masses of people. They are denouncing the fact that automobiles, air conditioners and television sets are no longer toys of the rich, but are within the means of an average American worker—a beneficence that does not exist and is not fully believed anywhere else on earth.
What do they regard as the proper life for working people? A life of unrelieved drudgery, of endless, gray toil, with no rest, no travel, no pleasure—above all, no pleasure. Those drugged, fornicating hedonists do not know that man cannot live by toil alone, that pleasure is a necessity, and that television has brought more enjoyment into more lives than all the public parks and settlement houses combined.
What do they regard as luxury? Anything above the "bare necessities" of physical survival—with the explanation that men would not have to labor so hard if it were not for the "artificial needs" created by "commercialism" and "materialism." In reality, the opposite is true: the less the return on your labor, the harder the labor. It is much easier to acquire an automobile in New York City than a meal in the jungle. Without machines and technology, the task of mere survival is a terrible, mind-and-body-wrecking ordeal. In "nature," the struggle for food, clothing and shelter consumes all of a man's energy and spirit; it is a losing struggle—the winner is any flood, earthquake or swarm of locusts. (Consider the 500,000 bodies left in the wake of a single flood in Pakistan; they had been men who lived without technology.) To work only for bare necessities is a luxury that mankind cannot afford.
See also: Ecology/Environmental Movement; Economic Growth; New Left; Pollution; Science; Soul-Body Dichotomy.
Copyright © 1986 by Harry Binswanger. Introduction copyright © 1986 by Leonard Peikoff. All rights reserved. For information address New American Library.
Excerpts from The Ominous Parallels , by Leonard Peikoff. Copyright © 1982 by Leonard Peikoff. Reprinted with permission of Stein and Day Publishers. Excerpts from The Romantic Manifesto , by Ayn Rand. Copyright © 1971, by The Objectivist . Reprinted with permission of Harper & Row, Publishers, Inc. Excerpts from Atlas Shrugged , copyright © 1957 by Ayn Rand, The Fountainhead , copyright © 1943 by Ayn Rand, and For the New Intellectual , copyright © 1961 by Ayn Rand. Reprinted by permission of the Estate of Ayn Rand. Excerpts from Philosophy: Who Needs It , by Ayn Rand. Copyright © 1982 by Leonard Peikoff, Executor, Estate of Ayn Rand. Reprinted by permission of the Estate of Ayn Rand. Excerpts from "The Philosophy of Objectivism" lecture series. Copyright © 1976 by Leonard Peikoff. Reprinted by permission. Excerpts from Alvin Toffler's interview with Ayn Rand, which first appeared in Playboy magazine. Copyright © 1964. Reprinted by permission of Alvin Toffler. All rights reserved including the right of reproduction in whole or in part in any form. Used by arrangement with Plume, a member of Penguin Group (USA), Inc.
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So since the purpose of this blog is to detail life as a married couple, I figured I would start retrospectively with different (mostly boring, except for this one) events. So sit back, buckle your seat belts, and please keep all hands, arms, feet, and legs inside the vehicle at all times.
I'll back track a little before we got married to fill you in on why we got married, and moved to Texas in the first place. Kyle proposed to me on December 22, 2017. It was a dream and honestly my favorite day ever in life thus far. The love I felt that day outpouring from not only him, but all of our friends and family was just perfect. If I could relived that night a million times again I definitely would. After that, life was peachy. January was a tough month, my grandpa passed away which was the hardest thing I've had to go through in life thus far. We had gone to Amelia Island to say our last good byes to him and on the drive home Kyle and I were talking about our future. What we wanted it to look like. Naturally, his career path came up. At the time, he worked at a company doing a boring job where he was ridiculously bored. He needed to be challenged and I voiced that (quiiiite possibly a little to often, sorry babe!) to him. His ultimate goal was to work in sports. He had applied for many positions, and even interviewed for a few with local sports teams. But they didn't lead any where. I told him if he wanted to work in sports he would need to broaden his horizons and look in other areas of the country.
Toward the end of January, he started applying for jobs. He applied for a sales job with FC Dallas (a MLS team, if you're clueless about sports like I am), had two phone interviews with them the following week and was offered a job. It was a great opportunity for him. An opportunity for him to get to work in sports. The only catch was, it was in Dallas (iiiif you couldn't guess). So we discussed, and ultimately we decided we would want to move together. Which meant we'd have to either elope, or live together premaritally. We decided it would be in our best interest for our hearts to elope. Lots of research, tears, stress, and one extensive online course to skip the three day waiting period after you get a marriage license to get married, we were at February 16, 2018. I'll also mention, we only had two weeks to pack up our lives and move. We were doing the most spontaneous thing I've ever done. Noticing a pattern? Life lately has been full of new experiences.
That morning, we went to the courthouse with our families and said some vows written by the state of Florida, exchanged rings, kissed, I flashed my bum to everyone (yikes) and went on our merry way. Then we got in our cars, which were filled to the briiim, and got on the road for our nearly 18 hour journey. When we moved, I had no job, Kyle's uncle and aunt were gracious enough to let us stay with them for a couple weeks, but we had no apartment. No furniture. Nada. We were pretty much starting from scratch. It was and interesting adventure. I'll detail our apartment in a later post. I'm sure future me will enjoy it.
Luckily, we got settled, I found a job, we got an apartment, and we began life on our own. Its weird, I'll be completely honest. Sometimes I still feel like I'm 16 and sometimes wonder what I'm doing with my life. I think thats part of life though. If you're not confused about life in your twenties then what are you actually doing (no really, whats your secret??).
So in a nutshell, thats why we eloped. February 16, 2019 we'll do an actual ceremony, with a dress thats not from Francesca's and at a place a little nicer than the courthouse.


I started working on this blog yesterday evening, but for some reason the pictures took forever uploading and was finished around 2 in the morning so I decided posting this today, instead!
Yesterday was great! We went to a sushi place that we love, and had a coffee later. I took pictures of the sushi place because it's unlike anything we have in Norway. There are little plates of sushi in different colours moving around and you grab what you want. It's really cool. The different colours represent different prices and you stack the empty plates next to you and they count it and that's how they know how much you need to pay. I think that is so cool and totally different from any restaurant in Norway.
The sushi place is located right by Grafton Street, which is one of my favourite places in Dublin! Grafton Street has amazing shops and it's always full of life. In the evening it's really beautiful because the entire street is lit up.
I saw these in a Chanel window. They are perfect! One day I'll wear shoes like that!
Ken may look cool and tough, but I know a secret. He always prefers strawberry frappuccino with cream! Lol!
I got my usual latte:) Costa latte, is the best in town!


The gist: Researchers found promising results for a new lung cancer treatment in a clinical trial—a research study with volunteer patients. The immunotherapy treatment combines the drugs MEDI4736 and tremelimumab. It is meant to boost a patient's own immune system to fight cancer.
"Early results for a closely watched cancer drug combination from AstraZeneca that boosts the immune system show the cocktail is promising, though limited patient numbers mean the data is far from conclusive.
"The British drugmaker, which fended off a $118 billion takeover bid from Pfizer in May in part by talking up its cancer drug prospects, has high hopes for the combination of two experimental drugs known as MEDI4736 and tremelimumab.
"The company is still exploring a range of doses, so testing of the drugs in lung cancer is taking time to yield results and data on only two dozen patients was reported at the European Society for Medical Oncology (ESMO) congress on Saturday.
"Chief Executive Pascal Soriot had said earlier this month that the ESMO numbers would be limited.
"Still, researcher Scott Antonia of the Moffitt Cancer Center in Florida said the early signals were encouraging, both for safety and efficacy. 'It looks very, very promising, he said.
Calabrò L, Morra A, Fonsatti E, Cutaia O, et al. Lancet Oncology. Sept 10, 2013.
Monoclonal antibodies to cytotoxic T-lymphocyte antigen 4 (CTLA4) have therapeutic activity in different tumour types. We aimed to investigate the efficacy, safety, and immunological activity of the anti-CTLA4 monoclonal antibody, tremelimumab, in advanced malignant mesothelioma.
Although the effect size was small in our phase 2 trial, tremelimumab seemed to have encouraging clinical activity and an acceptable safety and tolerability profile in previously treated patients with advanced malignant mesothelioma.


The guests at a hotel on the Spanish island of Gran Canaria can now enjoy the sea view from the pool bar in all weathers thanks to a conservatory from weinor.
The owner of Bahia Blanca, an apartment complex in Puerto Rico in the south of the Spanish sunny island of Gran Canaria, wanted to redesign his swimming pool area. He got the idea to equip the pool bar with the Terrazza patio roof and sliding glass glazing elements from weinor from a local specialist retailer. This has been supplemented by a Sottezza underlay awning. The guests can now relax in an exterior area protected from wind and sunshine. Here they can relax for a long period in a pleasant atmosphere, enjoy their cool drinks and have a sensational view of the sea and the coastline.
DThe guests can react to the weather totally flexibly thanks to the w17-c sliding glass elements. If it gets windy and fresh in the evenings, the glass sliding doors can be pulled to really easily. So they are then sitting protected in a conservatory. The full-surface glazing without any vertical struts provides full transparency. If visitors to the pool want to smell the sea air again, they simply pull the elements open.
The Sottezza conservatory awning provides reliable sun protection. It is installed under the glass roof and can therefore be left retracted as long as you like, whatever the wind loads. The Glasoase also looks extremely homely thanks to the large coloured fabric areas. The high-quality, spinneret dyed fabric adds a stylish touch to the patio.
The owner of the residence is so satisfied that he is now planning to have a weinor Glasoase installed at the other side of the pool area. He also would like to equip some apartments with weinor awnings.


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TOKYO (10 p.m.)
Commentary / World
The Jan. 6 riot and the possessive white male
A sense of entitlement was on display when far-right rioters stormed the U.S. Capitol
A police officer detains a pro-Trump protester as mobs storm the U.S. Capitol during a rally to contest the certification of the 2020 U.S. presidential election results in Washington on Jan. 6, 2021. | REUTERS
by Jan-werner Mueller
PRINCETON, New Jersey – The investigation by the U.S. House Select Committee on Jan. 6 is still a long way from establishing a comprehensive record of the assault on the Capitol last year, so one should resist facile generalizations about the insurrectionists.
Ideally, the committee will uncover sufficient evidence to make criminal referrals to the Department of Justice for the lead conspirators, not just the foot soldiers.
Still, some basic statements about the rioters seem uncontroversial. For example, we know that many of those who attacked the seat of American democracy saw themselves as staunch defenders of the U.S. Constitution. Did they simply have their facts wrong?
One key to understanding the event lies in a phenomenon that characterizes far-right parties and movements across countries: the promise of restoring privileged status to white men who think that women, nature, and the machinery of democracy ultimately belong to them. The Capitol was "taken" by assailants who displayed an astonishing sense of entitlement, chanting slogans like, "Whose house? Our house!" Observers who remarked that the insurrectionists behaved almost like tourists misinterpreted what they saw. Tourists — especially God-fearing conservative ones — generally do not illegally seize, deface, defecate in, or outright destroy the sites they visit.
A deeper insight into the day's events comes from the German philosopher Eva von Redecker. Inspired by the medical phenomena of phantom pain and phantom limbs, she recently coined the term "phantom possession" to make sense of our era's new authoritarianism.
For centuries, white men in America were entitled to claim much — including human beings — as their personal property. The natural environment was there for the taking, and women were expected to provide sex and various forms of care in accordance with coverture (legal submission to the husband). That their reproductive capacities were subject to men's control went without saying.
The North American colonists seized territory that had first been declared terra nullius (land belonging to no one), even though there had in fact been many people there before. And while (white) women could not be bought and sold as property, coverture meant that women were effectively under men's control. It is worth remembering that in some Western democracies, wives could not accept employment without their husband's consent until the 1970s, and marital rape was not outlawed until the 1990s.
As the African American scholar W.E.B. Du Bois famously observed, the right to oppress certain groups long served as compensation for poorer whites who themselves suffered under some form of domination. A sense of relative superiority generated a "psychological wage," helping to keep the prevailing social structure intact.
Things have since changed. And though they have not changed fast enough (even Sweden still has a gender pay gap of at least 5%), the social transformation has been sufficient to generate the rage and resentment over phantom possessions that characterize far-right movements everywhere.
One hallmark of modern property is that you can generally do with it as you will. As the great 18th-century British jurist William Blackstone explained, property is "that sole and despotic dominion which one man claims and exercises over the external things of the world." And under the Code Napoleon, one perquisite of owning property was the right to abuse or even destroy it.
There is a psychological dimension to this legal idea: An act of destruction can be used to prove that something is one's own. This dynamic becomes horrendously clear when men decide to kill or disfigure the women they claim to love rather than tolerate their emancipation (which literally means an exit from property, from the Latin mancipium).
Viewed in this light, it is perhaps no surprise that most of the insurrectionists were men, many of whom donned military gear and pretended to engage in combat against supposed enemies of the U.S. Constitution. The man who put his feet up on a desk in House Speaker Nancy Pelosi's office was asserting "despotic dominion," seeking to make the phantom real.
As long as far-right acolytes assume that they are entitled to things that are in fact not theirs to own, it does little good to explain to them what democracy is really about, or to point out that they are attacking the very thing they claim to value. If U.S. democracy is not exactly as they conceive it — the exclusive possession of white men — they would rather destroy it than let it become responsive to majorities comprising people of color.
Of course, far-right politics is not entirely reducible to misogyny. The far right's constituency has always been a minority, so what matters most is whether far-right parties and politicians can form coalitions that will satisfy a broader set of groups. Donald Trump, for example, appealed to some segment of the wealthy who were looking for deregulation and tax breaks.
Nonetheless, as Shirin Ebadi and other female Nobel laureates note in a recent essay, "the foundational autocratic bargain" promises a "restoration of private privileges of men, and of economic and social elites, in exchange for tolerance of the erosion of democratic freedoms." It thus calls for a systematic assault on anything resembling female self-ownership, not least women's reproductive rights, which have been sharply curtailed in right-wing redoubts, most recently in Poland, Mississippi, and Texas.
In the grand scheme of things, it is tempting to interpret the far-right's rage as a sign that things ultimately are changing for the better. In this telling, it is the insurrectionists who constitute the "resistance," and theirs is a losing battle.
But those who have suffered under Trump, Brazilian President Jair Bolsonaro, and Poland's de facto leader, Jaroslaw Kaczynski, are still bearing the costs, as are the Jan. 6 terrorists' victims and their families. A full reversal of female and minority emancipation may be a far-right pipe dream, but further acts of destruction by white men seeking sole and despotic dominion are more than likely.
Jan-Werner Mueller, professor of politics at Princeton University, is a fellow at The New Institute, Hamburg. His most recent book is "Democracy Rules" (New York, Farrar, Straus and Giroux, 2021, London, Allen Lane, 2021.) © Project Syndicate, 2022.
U.S., Washington, Donald Trump, 2020 u.s. presidential election, Capitol riot


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The first trailer for Jurassic World: Fallen Kingdom features dinosaurs and erupting volcanos
'What could go wrong?'
By Andrew Liptak@AndrewLiptak Dec 7, 2017, 9:24pm EST
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Somehow, the thrill of watching dinosaurs eat people doesn't get old, which is one reason why we're getting a sequel to 2015's Jurassic World, Jurassic World: Fallen Kingdom. After a brief tease for the film at the end of November, Universal has released the first trailer for the film. Not only does it have plenty of dinosaur action, but there's also an exploding volcano.
Directed by A Monster Calls J.A. Bayona, the film is set after everyone escaped from the former theme park on Isla Nublar. The trailer opens with the park's former manager, Claire Dearing (played by Bryce Dallas Howard), catching up with Owen Grady (Chris Pratt), who's trying to convince him to come with her as she returns to the island. It seems that a volcano on the island has begun to erupt, and the dinosaurs that InGen brought to life are in danger of being wiped out.
Claire heads up a group dedicated to saving their creations, the Dinosaur Protection Group, and the plan seems to be to bring the dinosaurs off the island to safety. However, not everyone is on board with the idea: Jeff Goldblum, who reprises his role as mathematician Dr. Ian Malcolm, tells a governmental committee that "these creatures were here before us, and if we're not careful, they're gonna be here after us."
Jurassic World: Fallen Kingdom hits theaters on June 22nd, 2018.
Dinosaurs and volcanoes: all the news, trailers, and commentary for Jurassic World: Fallen Kingdom
Jurassic World: Fallen Kingdom has the exact same characters as Rampage
Jurassic World: Fallen Kingdom teaser confirms we still want dinosaurs to murder us
Next Up In Film


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Q: Exchange 2010 is sending emails from accounts that do not exist? All of a sudden, our exchange server has started sending out emails to .com.br addresses from accounts that do not exist in our organization. For example:
sadfjkh32@myorganization.com

sasdfsdkh4352@myorganization.com

sadhdf@myorganization.com

Please help.

A: You should review your recieve connector configuration to make sure you are not allowing someone to relay mail over your server.
Aditionally use the message tracking in esm and look for those emails.
Try to find the source IP address of those emails, meaning where they are generated.
Are they generating from an application server on your network. Maybe a scanner device, a pc...
As soon as you find the ip address you will have a better idea what is going on
Liran Zamir

redpajama_set_name: RedPajamaStackExchange


Watch this amazing video about the US Media and the Israeli-Palestinian Conflict.
Peace to all my REAL Jews!
hey Amir, you remember how you posted an article a while back about extremist salafees or what not and then retracted and subhanallaah….now this war, you see what I mean, little brother there are too many people hating on us muslims and we shouldnt be hating on each other. May Allaah bless your tears for your brothers and sisters and for the ummah. May Allaah accept our prayers and guide us to being true servants of Allaah.
May Allaah guide the people of Filisteen and Lebanon towards AL-Islaam and full submission to Allaah.
May Allaah cause people to stay away from the nightclubs that were prevalent in Lebanon, the free-mixing, promiscuity, the indecent clothes, the alcohol and may Allaah give hidaya to people of that region to follow islaam and to give up sins and likewise for us muslims in the rest of the world.
For no one is powerful, not the US, not the bani israel and they cannot do anything except that it is the Will of Allaah. And Allaah Wills whatsoever and it happens. For some it is a test of eemaan for others a punishment but in the end the reaction should be the same: to recognize our weaknesses, our sins and submit to the Creator. To not worship those that cannot do us any benefit and to remember constantly the One Who put us on this earth.
You are right. We should be united, but there are some extremist salafis who will not even unite with the majority. It is those that I still dislike and they are a burden to the movement to bring peace and justice for all.
those guys are khwarajee or deviants, they have deviated, they are the one's who killed 'Ali RA and thought they were more pious than the sahaabah. We all should read into our religion, do our research. The so called "salafees" are not salafees but in fact khwarajees, they have extreme ibaadah that impales the ibaadah of even the sahaaba and they make takfeer left and right and even based on major sins. Your labeling that extreme salafee is a misnomer highly, because the only person that thinks they are salafee is themselves and the kuffaar, the real salafees(ahem, like yours truely) have nothing to do with them and it damages my reputation and who I am and teh da'wah that I do when you call the likes of "THEM" salafees.
but no matter how many times I have said this, no one listens to what I am saying.
It is ok, we have more pressing issues at hand.
this made me sick to my stomach, but at the same time was the only remedy for my unrest..may Allah bless the Palestinians and strengthen them with a strong help, ameen. and may He also bless the righteous who fight against the occupation and injustice, and curse those who further it intentionally, ameen.


St. Columbkille Church was opened in 1921 in Los Angeles. The parish was formerly a mission from Holy Cross Church and extended to almost the southern extremity of the city. There was a building at the corner of 64th Street and Main, but a complete parish plant was finished in 1923 with a school, convent, and rectory. In 1936 the church and rectory were remodeled and re-dedicated. The Church was again remodeled in 1999 thanks to the efforts of parishioners and generous donors. Father Thomas O'Toole was the first pastor. Monsignor Timothy Galvin was pastor for twenty-six years between 1946 and 1972. Monsignor Michael Lenihan, an associate in 1964, was named pastor in 1972, followed by Father Jules Mayer, Fr. John Keese, Msgr. Timothy Dyer and Fr. Francis Mendoza. The current pastor is Fr. Ever Quintero. The parish, built originally for Irish and German immigrants evolved into an African-American community and in the 1980's became largely Latino. St. Columbkille is clustered/twinned with Nativity Church. Currently the parish is very active and offers various programs led by lay leaders. Programs include: family catechesis, religious education, confirmation, RCIA, RCIC, youth group, prayer groups, Movimiento Familiar Cristiano, St. Vincent de Paul Society, and more.
To schedule a baptism, wedding, quinceañera, funeral or other special Mass.


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Pressure on Uganda builds over anti-gay law
Human rights campaigners fear they just have "days" to stop Uganda from passing its Anti-Homosexuality Bill following the remarks of the country's parliamentary Speaker Rebecca Kadaga.
Online activist group Avaaz.org is looking to get 2,000,000 signatures for their petition.
On its website, the group says of the bill:
"We stopped this before: first, 800,000 of us forced Uganda's president to step in and silence the hate, when it returned with a vengeance, an amazing 1.2 million of us led a global outcry that stalled the anti-gay bill's final vote until time ran out. Now it's back and it's going to take an unprecedented wave of opposition to kill this bill for good."
Earlier this week, Hacktivists from online group Anonymous in the US released names and email addresses of Ugandan officials linked to Uganda's Committee on Legal and Parliamentary Affairs as an act of protest.
The committee has previously recommended that the bill should be passed by lawmakers and while the Ugandan government seems wary of giving it approval – there is widespread political support for it to be signed into law.
Clare Byarugaba, the co-ordinator of Uganda's Civil Society Coalition on Human Rights and Constitutional Law, said her organisation would challenge the law in the constitutional court.
International donors have threatened to cut off aid to Uganda if the country does not do more to protect the rights of gay people.
More: Africa, Africa, Anonymous, anti-gay law, anti-gay laws, Anti-Homosexuality Bill, Avaaz.org, Committee on Legal and Parliamentary Affairs, Hacktivists, homophobic law, human rights campaigners, Speaker Rebecca Kadaga, Uganda, Uganda


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Prince of Egypt World Premiere
Music and Lyrics by Stephen Schwartz and Book by Philip LaZebnik
By: Victor Cordell - Oct 21, 2017
http://forallevents.info/reviews/the-prince-of-egypt/
Moses (Diluckshan Jeyarantam), Ramses (Jason Gotay) as charioteers. All photos by Kevin Berne.
Cast as the burning bush.
Midianite princess Tzipporah (Brennyn Lark) and Moses (Diluckshan Jeyaratnam).
"A friend loveth at all times, and a brother is born for adversity," King Solomon from the book of Proverbs, the Bible.
From the opening pleas of the theme song "Deliver Us," the sweep of Stephen Schwartz's The Prince of Egypt fulfills expectations. A Biblical epic with powerful messages about belonging and becoming and a strong score that drives the plot line unfolds. This world premiere production possesses all the Broadway musical characteristics that should lead it to that destination. Director Scott Schwartz, son of Stephen, has guided plays on and off Broadway and at a laundry list of top regional theaters. He coordinates the creative elements into a spellbinding, cohesive whole.
The central storyline is that of Moses, told with the usual literary license taken by Hollywood and Broadway writers. In this case, the book for the musical is taken from the 1998 film of the same name, written by Philip LaZebnik. In The Prince of Egypt, Moses is found in the river rushes by Queen Tuya and is raised as a prince and the younger brother of Ramses, who in later (real) life would become Ramses II, perhaps the greatest pharaoh in Egyptian history. After a somewhat dissolute childhood, Moses would find that he had been a Hebrew foundling; would repudiate his royal heritage; and, in the Biblical rendering, would lead the Hebrew slaves to freedom. Along the way, many episodes from the Biblical book of Exodus are revealed.
Much of the narrative focuses on the two brothers raised in harmony but later faced with monumental challenges that would pit them against one another. Their loyalties and principles are tested in an unforgiving crucible that threatens to destroy them both. At a societal level, the play deals with the problems of peoples of different cultures and faiths and how they can live in peace. This applies not only to the Egyptians and Hebrews, but also the Midianites and other peoples of the region.
Kevin Depinet's splendid staging is simple, yet grand, in part because of the height of the stage's space. Mike Billings' filtered lighting in soft earth tones projected on the back wall creates a warm sense. The set is bare, but large styrofoam building blocks are moved about to represent everything from temple walls to the pharaoh's throne. As befits an epic, the ensembles become a dominant and moving element in the staging. Choreographer Sean Cheesman uses spectacular African-styled writhing and stomping dance and movement with thrashing limbs, expressive finger movement, and bent-forward torsos. But equally effective is how massings of human forms are used to decorate the stage, as well as the clever use of bodies as figurative chariots in a race between the brothers.
Schwartz's music is strongly idiomatic with an exotic, somewhat Middle Eastern motif. Each song on its own is melodious, but collectively there could be more distinctiveness among them. However, many of the lyrics are vital to the story telling and quite memorable.
Diluckshan Jeyaratnam, who leads a truly multi-ethnic cast, charms as Moses and displays great vocal skill throughout. Perhaps his most important turn is "Footprints in the Sand," when he admits that he has been a fool but hopes that he can rise above to make a lasting contribution. Jason Gotay is effective as the ever-conflicted Ramses who longs for Moses to remain as his brother, no matter what, as depicted in the wonderful duet that foretells their separate paths, "I Will Make it Right (Ramses' part) / No Power on Earth (Moses' part)." And perhaps the signature song from the play is the touching and beautiful Oscar-winning number about what miracles you can achieve "When You Believe."
The Prince of Egypt has its weaknesses. Many characters are one-dimensional, but it is difficult to cover so much ground without some short shrift. Biblical stories whiz by like a Ferrari on a freeway, and they are scrubbed of their didactic moralizing. But lest we forget, this is a musical entertainment for the many, not a Sunday School lesson for the few. One technical criticism is that because of the use of overhead speakers to project voices, sometimes the sound seems disembodied. Notwithstanding, musical lovers should find this a worthy entertainment.
"The Prince of Egypt," a world premiere based on the DreamWorks Animation Film with music and lyrics by Stephen Schwartz and book by Philip LaZebnik is produced by TheatreWorks and plays at Mountain View Center for the Performing Arts, 500 Castro Street, Mountain View, CA through November 5, 2017.
Courtesy of For All Events.


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Research Geophysics Position
Research Scientist in Earth and Planetary Sciences
The Department of Earth & Planetary Sciences at the University of California, Santa Cruz (UCSC) invites applications for a research scientist in geophysics as applied to industrial or societal problems. Under the direction of the Department Chair, the research scientist will build a program that is well-integrated with our basic science expertise in earthquakes, seismology and related disciplines. We are particularly interested in candidates who can expand our impact in geohazards. Potential fields of interest include rock mechanics and/or new geophysical observation methods.
The successful candidate should demonstrate broad applicability and a potential for external collaborations and/or industry sponsorship. Scientists in the *Professional Research* title series are individuals with mature research portfolios who normally serve as principal investigators on grants and develop a full research program. The position is funded at 50% through university funds and is envisioned as a career position with regular merit and promotion reviews.
The current geophysics group at UC Santa Cruz includes expertise in earthquake mechanics, seismology, structural geology, and geodynamics (see https://websites.pmc.ucsc.edu/~seisweb/ for more details). The group collaborates with the researchers working on hazards at the USGS Coastal Science Center and seeks to foster further connections there. The group also includes significant connections to community initiatives such as Subduction Zone in Four Dimensions (SZ4D) and Southern California Earthquake Center (SCEC) that can be strategically complemented by the successful candidate.
The research scientist will be expected to develop their own research program and work collaboratively with existing department members addressing Earth hazards. Science that is complementary to current efforts in the department and community initiatives such as SCEC and SZ4D is of particular interest. Engagement with the active tectonics efforts in the USGS Coastal Center in Santa Cruz is also encouraged.
Applicants with expertise in writing successful grant proposals, excellent interpersonal skills for cultivating collaborations, exceptional communication skills, and strong presentation skills, and/or innovative vision for collaborations are strongly encouraged to apply.
Review of applications will begin after Dec.21 and will continue until the position is filled. Please apply by this date for full consideration.
Application materials include cover letter, CV, research statement, list of publications, and diversity statement. Ph.D. is required.
For additional information and to apply, go to:
https://recruit.ucsc.edu/JPF01416
Questions concerning the application process should be sent to Heather Savage at hsavage@ucsc.edu.
This job was posted by a member of the IRIS community. For clarification or details about this position, please use the contact information found in the job posting itself.


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Enfortumab Vedotin Demonstrates Superior Efficacy versus Chemotherapy in Bladder Cancer
Bladder Cancer, In the Literature
Patients with advanced urothelial carcinoma and disease progression after treatment with platinum-based chemotherapy and PD-1 or PD-L1 inhibitors have limited treatment options. Enfortumab vedotin (Padcev), a Nectin-4–directed antibody and microtubule inhibitor conjugate, demonstrated an objective response rate (ORR) in more than 40% of patients with advanced urothelial carcinoma who had progression after previous treatment.
Maintenance Avelumab New Standard of Care for Advanced Bladder Cancer
August 2020, Vol 11, Special Issue: Payers' Perspectives in Oncology
Interim analysis of the phase 3 JAVELIN Bladder 100 clinical trial showed that maintenance therapy with the PD-L1 inhibitor avelumab (Bavencio) plus best supportive care significantly prolonged overall survival (OS) versus best supportive care alone in patients with advanced urothelial carcinoma whose disease did not progress with first-line platinum-based chemotherapy.
Adjuvant Atezolizumab Did Not Show Disease-Free Survival Benefit in High-Risk Urothelial Cancer
Adjuvant therapy with atezolizumab (Tecentriq) did not meet the primary end point of disease-free survival (DFS) in patients with muscle-invasive urothelial cancer (MIUC) at high risk for recurrence versus observation alone in the primary analysis of the IMvigor010 trial.
FDA Grants Priority Review to Keytruda for Patients with High-Risk, Non–Muscle-Invasive Bladder Cancer
By Yvette Florio Lane
Bladder Cancer, FDA Approvals, News & Updates, Immunotherapy
On December 2, 2019, Merck announced that the FDA has granted priority review for its supplemental biologics license application for the anti–PD-1 agent pembrolizumab (Keytruda).
Tecentriq (Atezolizumab) Receives New Indication for First-Line Treatment of Locally Advanced or Metastatic Urothelial Carcinoma
Bladder Cancer, FDA Approvals, News & Updates
2018 Third Annual Oncology Guide to New FDA Approvals
Urothelial carcinoma is the most common subtype of bladder cancer, accounting for more than 90% of bladder cancer diagnoses in the United States. In 2017, more than 79,000 bladder cancer cases were diagnosed in the United States, and more than 16,000 people died from this disease. The prognosis is favorable for patients with localized disease, with a 5-year relative survival rate of 78% for all stages of bladder cancer, which decreases to 5% for patients with distant disease.
Imfinzi (Durvalumab) a New PD-L1 Inhibitor Approved for the Treatment of Advanced or Metastatic Urothelial Cancer
Urothelial carcinoma is the primary subtype of bladder cancer, which is the sixth most common cancer in the United States. More than 79,000 cases of bladder cancer were estimated to be diagnosed, and nearly 17,000 people to die from this disease in 2017.
Atezolizumab Could Be Start of "Seismic Shift" in Metastatic Bladder Cancer Therapy
Bladder Cancer, Solid Tumors
August 2016, Vol 7, No 7, Special Issue: Payers' Perspectives in Oncology
Atezolizumab (Tecentriq) shows promise as primary therapy in patients with cisplatin-ineligible, locally advanced metastatic urothelial (bladder) cancer, according to data from the IMvigor210 study presented at ASCO 2016.
Hispanics More Likely than Caucasians to Develop Major Complications after Radical Cystectomy
By Rosemary Frei, MSc
November 2013, Vol 4, No 9
Vancouver, Canada—The odds of having a major complication after a radical cystectomy, which is performed as part of the treatment for bladder cancer, are higher for Hispanics than for Caucasians, researchers have found. They calculated that the rate of such complications was 23.53% for Hispanic Americans compared with 16.09% for Caucasian Americans.
Mutational Analysis Leads Search for New Treatments for Bladder Cancer
By Debra Wood, RN
Bladder Cancer, Genitourinary Cancers Symposium
April 2011, Vol 2, No 2