You need to read this post if you are experiencing any pain or discomfort from the long days in the office.
Musculoskeletal injuries are rampant in the workplace.
One of the most common complaints from office workers are injuries known as repetitive stress injuries (R.S.I.) and the main cause of these injuries is an in-effective, poorly adjusted workstation set-up.
Your Work-station at a desk job usually includes your chair, desk, computer monitor, keyboard, mouse, phones and filling.
At work most people simply use the computer that was assigned to them when they first started at their job without thinking of how it should be set up ergonomically.
Maybe you also just plopped down in the chair without recognizing there could be some adjustments to better fit your body and needs.
Each body is different, with different angles, torso length, arm lengths, etc.
It is imperative that you have your desk set up properly to avoid muscle tension, headaches, eye-strain, and injury.
Here are the top 10 tips to consider when "fitting" your body to your desk computer.
You DON'T NEED A FANCY CHAIR!
a) Sit in a chair with a seat that allows for 2-3 inches of space between your knees and the edge of the seat.
b) Your knees should be at a 90 degree angle.
c) Both feet should be able to be placed flat on the floor or on a foot-rest, if your legs are too short to touch the floor. You don't have to keep both feet on the floor the entire time, it's best to change placement as often as possible. You can even sit with legs crossed, or under you — just mix it up!
d) Your lumbar curve should be supported preferably by your own back strength, but you can also use the seat or supplemental padding following the curves of your spine along your low back.
e) Set arm-rests low or remove them completely so that while working, elbows are free and shoulders relaxed.
a) Place keyboard so elbows are at a 90-100 degree angle.
b) Use a wrist support to keep your wrist off the desk or keyboard tray. Wrists should be parallel to flat surface, slightly elevated and straight, without fingers higher or lower than wrist.
a) Set monitor so that eyes are level with the top of the screen for a 15″ monitor and 1/4 of the way down from top of the glass on a monitor 17″ or larger.
b) Eye distance from screen should be 12-24″ and no more than one arm's length away.
Some suggest lowering the monitor and keeping it angled at about 45 degrees, so your head is upright, but your eyes are looking down. This keeps more of your eyeball covered by your eye lid to prevent eye dryness and also keeps your head in a neutral position.
You can play with both options to see what feels and works best for your desk set-up.
a) Place mouse on the same level as close to the keyboard as possible.
b) When possible move your entire arm, not just your wrist.
a) When working from paper, use a document holder rather than laying it on the desk.
b) Keep the document as close to you as possible, either at eye level or directly in front of you, just below the monitor.
c) If you're doing a lot of reading from an external document, switch the placement of it often so you're not always turning only too one side.
a) If you use the phone frequently you must use a head set or a speaker phone. This is especially true if you type or write while on the phone.
b) If you are not using a headset hold the receiver to your ear. Do not cradle receiver between chin and shoulder.
c) Place the phone just to the left side of your desk if you are right handed and to the right side if you are left handed.
d) Place the phone close but it is not bad to move and have to extend your reach to use it, to get more movement.
e) Be sure cords are out of the way, so you're not wrestling with them!
a) Remove precariously perched items from your work area. If you are afraid you'll knock something over, you may mal-adjust your body accordingly.
c) Notice and make appropriate changes if you always turn to one side or the other to talk with people or reach into a drawer.
d) Maintain enough clearance under desk for legs to move easily and often.
a) Hold your head centered above your torso – not forward.
b) Sit up tall with or without lumbar support.
c) Keep shoulders relaxed and down.
This means every time you hit the 'save' command, do a few shoulder circles, neck stretches, or shake your arms. This should only take a few seconds and not be an interruption to your work.
b) Every 15-20 minutes get up, even if its just for 60 seconds to move and stretch. This allows the blood to circulate and eases muscle tension.
c) Use a kitchen timer or software to remind you to move, get up, or change tasks.
Don't go out and buy anything new until you know what you need. All those fancy, expensive chairs may not be necessary or fit you properly!
Start by determining what, if any thing, is adjustable at your workstation. Most chairs, monitors, and keyboard trays can be lifted or lowered, though most desk heights are not adjustable.
I always recommend starting with your keyboard tray and chair in tandem.
Place the seat of your chair at the proper height for your knees so they are at a 90 degree angle. Sit up straight and place your hands on the keyboard. Are your elbows at a 90 degree angle?
If you are a tall person, and your chair is set correctly, you may find your keyboard tray too low. If so, you can either raise your keyboard tray to a higher position or place your keyboard and mouse up onto the desktop. If you do move your keyboard up on the desktop you may need to raise your monitor. Many stores sell all sorts of nifty monitor supports that not only raise your computer, but provide additional storage space underneath for stamps, papers, etc.
If you are a shorter person, begin with finding the correct angle for your elbows. Once you know where that placement of your elbows should be, raise your chair so that your elbows are in this correct alignment. A footrest is necessary to elevate your feet so your knees are at the 90 degree angle.
Once your chair and keyboard fit you correctly, you can now begin to raise or lower your monitor so the top of the screen is at eye level. Move your monitor close enough to you so you don't have to lean in or press your head forward to see the screen.
Adjust your phone, document holder, files, etc., so they are in the right places to be able to access easily and ergonomically.
Once in this new ergonomic alignment, you should feel less pain and be more productive.
With the right set-up, you can enjoy your new work station, be more productive, cut down on work comp or time off for recovery and be rewarded with years of comfortable work!
To learn more about ergonomics and to see how we can educate employees at your company CLICK HERE!
I would like to thank you for sharing this amazing content with us. The most informative point in the content is 'Posture to Maintain'. In today's world, we need to have a proper posture while working, as bad posture causes several cardiovascular problems.
Thanks for the comment. We know posture is important because of the strain we often have on specific areas of our body if we're slouching with our heads forward or shoulders elevate.
HOWEVER, we should be most aware of the importance of movement, rather than staying static. Even if we are sometimes in 'poor posture', the key is to change positions frequently to activate muscles and stretch and change the gravitational forces pulling on our structure.


text:
Top cities between Dalyan and Mantua
Best stops along Dalyan to Mantua drive
40 Best Stops Between Dalyan and Mantua
How long is the drive from Dalyan to Mantua?
The direct drive from Dalyan to Mantua is 1617 mi (2602 km), and should have a drive time of 23 hrs 30 mins in normal traffic.
If you're going on a road trip from Dalyan to Mantua, we did the research for you and compiled some great stops along the way — with Istanbul, Venice, Salzburg, Padua, Ravenna, Belgrade, Trieste, Ljubljana, Zagreb, and Sofia and top places to visit like Hagia Sophia and The Blue Mosque, or the ever-popular A1 Travertines of Pamukkale.
The top cities between Dalyan and Mantua are Istanbul, Venice, Salzburg, Padua, Ravenna, Belgrade, Trieste, Ljubljana, Zagreb, and Sofia. Istanbul is the most popular city on the route — it's 8 hours from Dalyan and 16 hours from Mantua.
Istanbul is a major city in Turkey that straddles Europe and Asia across the Bosphorus Strait. Its Old City reflects cultural influences of the many empires that once ruled here. In the Sultanahmet district, the open-air, Roman-era Hippodrome was for centuries the site of chariot races, and Egyptian obelisks also remain. The iconic Byzantine Hagia Sophia features a soaring 6th-century dome and rare Christian mosaics.
15 minutes off the main route, 31% of way to Mantua
Sofia is the capital of the Balkan nation of Bulgaria. It's in the west of the country, below Vitosha Mountain. The city's landmarks reflect more than 2,000 years of history, including Greek, Roman, Ottoman and Soviet occupation. Medieval Boyana Church has 13th-century frescoes. Built by the Romans in the 4th century, St. George Rotunda Church has medieval and Ottoman decoration dating to the 10th century.
9% as popular as Istanbul
10% as popular as Istanbul
Zagreb, Croatia's northwestern capital, is distinguished by its 18th- and 19th-century Austro-Hungarian architecture. At its center, Upper Town is the site of the Gothic, twin-spired Zagreb Cathedral and 13th-century St. Mark's Church, with a colorfully tiled roof. Nearby is pedestrian-friendly Tkalčićeva Street, lined with outdoor cafes. Lower Town has the main square, Ban Jelačić, plus shops, museums and parks.
Salzburg is an Austrian city on the border of Germany, with views of the Eastern Alps. The city is divided by the Salzach River, with medieval and baroque buildings of the pedestrian Altstadt (Old City) on its left bank, facing the 19th-century Neustadt (New City) on its right. The Altstadt birthplace of famed composer Mozart is preserved as a museum displaying his childhood instruments.
2 hours off the main route, 84% of way to Mantua
Ljubljana is Slovenia's capital and largest city. It's known for its university population and green spaces, including expansive Tivoli Park. The curving Ljubljanica River, lined in outdoor cafes, divides the city's old town from its commercial hub. Ljubljana has many museums, including the National Museum of Slovenia, displaying historic exhibitions, and the Museum of Modern Art, home to 20th-century Slovene paintings and sculptures.
Trieste is the capital city of the Friuli Venezia Giulia region in northeast Italy. A port city, it occupies a thin strip of land between the Adriatic coast and Slovenia's border on the limestone-dominated Karst Plateau. Italian, Austro-Hungarian and Slovenian influences are all evident in its layout, which encompasses a medieval old city and a neoclassical Austrian quarter.
1 hour off the main route, 93% of way to Mantua
The top stops along the way from Dalyan to Mantua (with short detours) are Hagia Sophia, Grand Canal, and St. Mark's Square. Other popular stops include The Blue Mosque, Plitvice Lakes National Park, and Fortress Hohensalzburg.
A1 Travertines of Pamukkale
20190 Pamukkale/Denizli, Turkey
Museum with glittering mosaics of Biblical scenes in vast, domed former Byzantine church and mosque.
Sultan Ahmet, Ayasofya Meydanı No:1, 34122 Fatih/İstanbul, Turkey
https://muze.gen.tr/muze-detay/ayasofya
The Blue Mosque
Well-known site, also known as the Blue Mosque, built in 1616 & containing its founder's tomb.
Sultan Ahmet, Atmeydanı Cd. No:7, 34122 Fatih/İstanbul, Turkey
http://www.sultanahmetcamii.org/tr/
Basilica Cistern
Huge underground Roman water source held up with 336 marble columns covering 9,800 sq. meters.
Alemdar, Yerebatan Cd. 1/3, 34110 Fatih/İstanbul, Turkey
http://yerebatansarnici.com/
Ephesus Ancient Theatre
Acarlar, 35920 Selçuk/İzmir, Turkey
Old Nessebar
ulista "Ivan Aleksandar" 11" 8231, 8231 Staria Grad, Nessebar, Bulgaria
Cathedral Saint Aleksandar Nevski
Iconic Bulgarian Orthodox church with Neo-Byzantine architecture & an underground museum.
pl. "Sveti Aleksandar Nevski", 1000 Sofia Center, Sofia, Bulgaria
http://www.cathedral.bg/
Weddings & cliff diving are popular at this ancient arched bridge over the Neretva River.
Stari Most, Mostar 88000, Bosnia & Herzegovina
http://www.tourguidemostar.com/
Nature reserve with walking trails, waterfalls & riverboat trips, plus monastic & castle ruins.
Lozovac, Croatia
http://www.npkrka.hr/
National park known for lakes, alpine forests, waterfalls & caves, plus hiking trails.
http://www.np-plitvicka-jezera.hr/
Sea Organ
Large experimental musical instrument mounted beneath a staircase & played by the waves on the sea.
Obala kralja Petra Krešimira IV, 23000, Zadar, Croatia
https://www.getyourguide.com/discovery/zadar-l1328/?partner_id=EPQA423&utm_medium=affiliate&placement=menu-bar&cmp=Orgulje&utm_force=0
Museum of Broken Relationships
Coffee store
Museum in a baroque palace displaying personal objects from former lovers along with brief synopses.
Ćirilometodska ul. 2, 10000, Zagreb, Croatia
http://www.brokenships.com/
Altstadt Salzburg
Busy Altstadt, the old town, centers on Getreidegasse, a narrow, pedestrian street with shops selling folk costumes and antiques. Mozart's Birthplace has exhibits on the composer's early life. The Domquartier includes the domed 1600s Salzburg Cathedral and the baroque Residence, with art by Rembrandt and Rubens. A steep path and a funicular lead to Hohensalzburg Fortress, with several museums and city views.
5020 Salzburg, Austria
Fortress Hohensalzburg
Huge 11th-century fortress complex on a hilltop with views over city to the Alps & museums.
Mönchsberg 34, 5020 Salzburg, Austria
https://www.salzburg-burgen.at/de/festung-hohensalzburg/
Pragser Wildsee
Picturesque lake in the mountains with climbing opportunities & a nearby historic hotel with dining.
39030 Prags, South Tyrol, Italy
Best of categories in Mantua
Other eats
DinnerLunch
Trendy restaurants
Other popular drives from Dalyan
Dalyan to
Can I drive from Dalyan to Mantua?
Yes! You can drive from Dalyan to Mantua.
How far is Mantua from Dalyan by car?
The drive from Dalyan to Mantua is 1617 miles (2602 km).
How long does it take to drive from Dalyan to Mantua?
Driving from Dalyan to Mantua should take you 23 hrs 30 mins in normal traffic. Check out How far is Dalyan to Mantua by car for more details.
How much would gas cost from Dalyan to Mantua?
Gas from Dalyan to Mantua would cost around $133 to $311 USD, depending on your vehicle's fuel efficiency.
Where should I stop on the way from Dalyan to Mantua?
You could check out Hagia Sophia and The Blue Mosque, or the always popular A1 Travertines of Pamukkale!
What are the best cities to visit between Dalyan and Mantua?
People love visiting Istanbul, Venice, and Salzburg, among others.
What's the weather like in Dalyan?
Weather in Dalyan in January
Weather in Dalyan in February
Weather in Dalyan in March
Weather in Dalyan in April
Weather in Dalyan in May
Weather in Dalyan in June
Weather in Dalyan in July
Weather in Dalyan in August
Weather in Dalyan in September
Weather in Dalyan in October
Weather in Dalyan in November
Weather in Dalyan in December
Planning a trip to Mantua?

redpajama_set_name: RedPajamaCommonCrawl


According to Wikipedia, the term non-binary or genderqueer "is a catch-all category for gender identities that are not exclusively masculine or feminine — identities which are outside the gender binary and cisnormativity. Genderqueer people may express a combination of masculinity and femininity, or neither, in their gender expression." Growing up, I was exposed to the idea of he or she. It wasn't until my 30's that I learned about the community of people who had a preference in the they/them pronoun. I imagine for some, the idea of not identifying as feminine or masculine, or possibly identifying as both is a foreign concept. Times have changed. We are stepping into an age where people are boldly and unapologetically declaring who they are and it no longer fits into cookie-cutter gender norms.
Being misgendered is something that happens quite often in the non-binary community. Although Tamilia's preference is to be addressed with a they/them pronoun, often times extra energy is put into explaining why they should not be addressed as she and her, despite the physical appearance.
New York City has proposed a third gender on the birth certificate, available to those who do not identify as male or female. "This proposal will allow transgender and non-conforming New Yorkers to live with the dignity and respect they deserve, and make our city fairer," said Mayor Bill de Blasio. Progress. Finally a community of people can feel included in what the rest of world has felt privileged to.


Tax or economic performance substantially differing from similar businesses.
Low transparency of tax affairs.
Large, one-off or unusual transactions,including transfer or shifting of wealth.
A history of aggressive tax planning.
Tax outcomes inconsistent with the intent of tax law.
Choosing not to comply or regularly taking controversial interpretations of the law.
Lifestyle not supported by after-tax income.
Treating private assets as business assets.
Non-arm's length transactions involving companies associated with members and SMSFs that may be intended to improperly redirect dividends to the SMSF.
Another area of focus is the incorrect claiming of franking credits or not applying appropriate governance to a franking credit balance.
Looking for tax or SMSF compliance advice, contact one of our advisers today.


text:
Q: C# JSON I cannot deserialize doubles. I get "Not a valid integer error" So I was trying to deserialize weather data but it doesn't work.
It just gives me an error:

"21.43 Not a valid integer"

Here's my code:
WebRequest request = HttpWebRequest.Create("https://api.openweathermap.org/data/2.5/weather?q=Budapest&APPID=CENSURED");
WebResponse response = request.GetResponse();
StreamReader reader = new StreamReader(response.GetResponseStream());

string Weather_JSON = reader.ReadToEnd();
MessageBox.Show(Weather_JSON);
RootObject myWeather = Newtonsoft.Json.JsonConvert.DeserializeObject<RootObject>(Weather_JSON)
double temp = myWeather.main.temp;
label2.Text = label2.Text + temp;

I've also tried using:
RootObject myWeather = Newtonsoft.Json.JsonConvert.DeserializeObject<RootObject>(Weather_JSON, new JsonSerializerSettings(){ Culture = System.Globalization.CultureInfo.InvariantCulture });

A: What is your RootObject's properties?
Weather value shouldn't be integer make it double, float or decimal

A: If you do not wish to change the dataType of Root.main.temp, then convert it to a double.
For example:
double temp = Double.TryParse(myweather.main.temp)
Note this method potentially throws an exception which you should handle.

A: 1 First of all, you have to deserialize your JSON object into an appropriate C# object with the help of Quick Type
You just paste ur json object into the left side textbox. It will automatically convert ur JSON data into a C# object. hahahaha. Easy, right?
Suppose, this my url: https://samples.openweathermap.org/data/2.5/weather?q=London,uk&appid=b6907d289e10d714a6e88b30761fae22
this is your JSON data after deserialize:
using System;
using System.Collections.Generic;

using System.Globalization;
using Newtonsoft.Json;
using Newtonsoft.Json.Converters;

public partial class Welcome
{
    [JsonProperty("coord")]
    public Coord Coord { get; set; }

    [JsonProperty("weather")]
    public List<Weather> Weather { get; set; }

    [JsonProperty("base")]
    public string Base { get; set; }

    [JsonProperty("main")]
    public Main Main { get; set; }

    [JsonProperty("visibility")]
    public long Visibility { get; set; }

    [JsonProperty("wind")]
    public Wind Wind { get; set; }

    [JsonProperty("clouds")]
    public Clouds Clouds { get; set; }

    [JsonProperty("dt")]
    public long Dt { get; set; }

    [JsonProperty("sys")]
    public Sys Sys { get; set; }

    [JsonProperty("id")]
    public long Id { get; set; }

    [JsonProperty("name")]
    public string Name { get; set; }

    [JsonProperty("cod")]
    public long Cod { get; set; }
}

public partial class Clouds
{
    [JsonProperty("all")]
    public long All { get; set; }
}

public partial class Coord
{
    [JsonProperty("lon")]
    public double Lon { get; set; }

    [JsonProperty("lat")]
    public double Lat { get; set; }
}

public partial class Main
{
    [JsonProperty("temp")]
    public double Temp { get; set; }

    [JsonProperty("pressure")]
    public long Pressure { get; set; }

    [JsonProperty("humidity")]
    public long Humidity { get; set; }

    [JsonProperty("temp_min")]
    public double TempMin { get; set; }

    [JsonProperty("temp_max")]
    public double TempMax { get; set; }
}

public partial class Sys
{
    [JsonProperty("type")]
    public long Type { get; set; }

    [JsonProperty("id")]
    public long Id { get; set; }

    [JsonProperty("message")]
    public double Message { get; set; }

    [JsonProperty("country")]
    public string Country { get; set; }

    [JsonProperty("sunrise")]
    public long Sunrise { get; set; }

    [JsonProperty("sunset")]
    public long Sunset { get; set; }
}

public partial class Weather
{
    [JsonProperty("id")]
    public long Id { get; set; }

    [JsonProperty("main")]
    public string Main { get; set; }

    [JsonProperty("description")]
    public string Description { get; set; }

    [JsonProperty("icon")]
    public string Icon { get; set; }
}

public partial class Wind
{
    [JsonProperty("speed")]
    public double Speed { get; set; }

    [JsonProperty("deg")]
    public long Deg { get; set; }
}

public partial class Welcome
{
    public static Welcome FromJson(string json) => JsonConvert.DeserializeObject<Welcome>(json, QuickType.Converter.Settings);
}

public static class Serialize
{
    public static string ToJson(this Welcome self) => JsonConvert.SerializeObject(self, QuickType.Converter.Settings);
}

internal static class Converter
{
    public static readonly JsonSerializerSettings Settings = new JsonSerializerSettings
    {
        MetadataPropertyHandling = MetadataPropertyHandling.Ignore,
        DateParseHandling = DateParseHandling.None,
        Converters =
        {
            new IsoDateTimeConverter { DateTimeStyles = DateTimeStyles.AssumeUniversal }
        },
    };
}

 public static async void RefreshDataAsync()
        {
                //check for internet connection
                if (CheckForInternetConnection())
                {
                    string uri = "https://samples.openweathermap.org/data/2.5/weather?q=London,uk&appid=b6907d289e10d714a6e88b30761fae22";

                    try
                    {
                        HttpResponseMessage response = await App.client.GetAsync(uri);
                        try
                        {
                            response.EnsureSuccessStatusCode();
                            var stringContent = await response.Content.ReadAsStringAsync();
                            welcome = Welcome.FromJson(stringContent);

                            FetchDataHelper.FetchUserData(welcome.User, UserModel_Data);
                            User_Data = welcome.User;
                        }
                        catch
                        {
                            return;
                        }
                    }
                    catch
                    {
                        //cannot communicate with server. It may have many reasons.
                        return;
                    }
                }
        }

After getting "welcome". You can show ur data!
Note: Don't copy and paste my code. Its just prototype. You have to paste your code in your project.

redpajama_set_name: RedPajamaStackExchange


A Guide On Cybercrime – What Is It And How To Protect Your Assets From Cyber Thieves?
Cybercrime isn't a new term if you're an avid web user and follower. A lot of people and companies suffer great losses done by hackers. The attacks can be done to extort ransom or they can be of a more personal nature like leaking confidential data and stealing private security information. However, whatever the case is, cybercriminals keep coming up with more and more dangerous ways to harm web users. In fact, even technological marvels like Google have been affected by hackers, leaving the security of millions vulnerable. It shows the magnitude of cybertheft. Keeping all such sensitive things in mind, the US government cybersecurity advisors lay out a number of ways that companies can follow to protect their assets.
How Can Companies Protect Their Assets From Cyber Snoopers?
Cybertheft is equally as dangerous as burglary. It is because hackers can steal almost everything – data, money, personal pictures and videos, and security information of clients, customers, and employees – if they gain access to your surveillance system. And the vulnerabilities that hackers exploit also carry solutions to strengthen the internal security system. Read through to learn more!
To conclude, hacking can be avoided if you are careful enough to not entertain buggy emails and phishing websites.
Windows 10 Home Key: Installation, Activation And Flexibility!


text:
Peter Benedict Kronheimer (born 1963) is a British mathematician, known for his work on gauge theory and its applications to 3- and 4-dimensional topology. He is William Caspar Graustein Professor of Mathematics at Harvard University and former chair of the mathematics department.

Kronheimer's early work was on gravitational instantons, in particular the classification of hyperkähler 4-manifolds with asymptotical locally Euclidean geometry (ALE spaces), leading to the papers "The construction of ALE spaces as hyper-Kähler quotients" and "A Torelli-type theorem for gravitational instantons."  He and Hiraku Nakajima
gave a construction of instantons on ALE spaces generalizing the Atiyah–Hitchin–Drinfeld–Manin construction. This constructions identified these moduli spaces as moduli spaces for certain quivers (see "Yang-Mills instantons on ALE gravitational instantons.") He was the initial recipient of the Oberwolfach prize in 1998 on the basis of some of this work.

Kronheimer has frequently collaborated with Tomasz Mrowka from the Massachusetts Institute of Technology. Their collaboration began at the  Mathematical Research Institute of Oberwolfach, and their first work developed analogues of Simon Donaldson's invariants for 4-manifolds with a distinguished surface.  They used the tools developed to prove a conjecture of John Milnor, that the four-ball genus of a -torus knot is .   They then went on to develop these tools further  and established a structure theorem for Donaldson's polynomial invariants using Kronheimer–Mrowka basic classes.  After the arrival of Seiberg–Witten theory their work on embedded surfaces culminated in a proof of the Thom conjecture—which had been outstanding for several decades.  Another of Kronheimer and Mrowka's results was a proof of the Property P conjecture for knots.  They developed an instanton Floer invariant for knots which was used in their proof that Khovanov homology detects the unknot.

Kronheimer attended the City of London School. He completed his DPhil at Oxford University under the direction of Michael Atiyah. He has had a long association with Merton College, the oldest of the constituent colleges of Oxford University, being an undergraduate, graduate, and full fellow of the college.

Besides his research articles, his writings include a book, with Simon Donaldson, on 4-manifolds, and a book with Mrowka on Seiberg–Witten–Floer homology, entitled "Monopoles and Three-Manifolds".  This book won the 2011 Doob Prize of the AMS.

In 1990 he was an invited speaker at the International Congress of Mathematicians (ICM) in Kyoto. In 2018 he gave a plenary lecture at the ICM in Rio de Janeiro, together with Tomasz Mrowka. In 2023 he was awarded the Leroy P. Steele Prize for Seminal Contribution to Research.

Kronheimer's PhD students have included Ian Dowker, Jacob Rasmussen, Ciprian Manolescu, and Olga Plamenevskaya.

References

External links
 Peter Kronheimer's home page at Harvard University

Living people
1963 births
20th-century British mathematicians
21st-century British mathematicians
Harvard University faculty
Fellows of Merton College, Oxford
Alumni of Merton College, Oxford
Fellows of the Royal Society
Whitehead Prize winners
International Mathematical Olympiad participants
Topologists
British mathematicians

redpajama_set_name: RedPajamaWikipedia


text:
Ardelyx's ambition to revolutionise kidney treatment
Catherine Longworth
A therapy to treat hyperphosphatemia is moving closer to the market after years of development by California-based company Ardelyx. The company's lead candidate Tenapanor is a targeted, small molecule therapy currently under FDA review.
As the pandemic surged this year, the disruption of healthcare systems posed a significant challenge for patients receiving kidney care.
While strict measures for infection control were introduced around the world in dialysis centers, COVID-19 still proved catastrophic for many with kidney disease according to Ardelyx CEO, Mike Raab.
As the co-founder of the biopharma company, Raab has been focusing on advancing patient care for kidney disease since 2009. "Patients who undergo dialysis are some of the most fragile. They can be going into a facility three times a week and God forbid, if someone has COVID-19, the chance of it spreading is significant," he told pharmaphorum. "We must remember with kidney failure; these are patients who can also be hypertensive or diabetic. They have lots of co-morbidities and are significantly at risk for COVID-19."
Although the number of patients on dialysis is more than 600,000 in the USA alone, the scale of kidney disease is sometimes forgotten, he said. "One of the examples I like to give to help people understand the magnitude of the problem is the opioid epidemic which has been a major area of focus in the United States."
"Elimination is critical, given what impact it has on these patients. Historically what has been used as a treatment is phosphorous binders that work somewhat like a sponge and absorb the phosphorus, then are excreted in the faeces. The problem is you need to take handfuls of this material for it to work, and it has been this way since the 1970s."
"Last year we lost just under 70,000 people due to opioid overdose and we lost almost 120,000 people on dialysis in the same year. The mortality rate for these patients is extraordinarily high which is not always understood."
In the US, dialysis care is available to all through Medicare, irrespective of age. The policy goes back to the early 1970s when Richard Nixon administration put comprehensive coverage in place. "The law means that all people with kidney failure on dialysis ultimately are covered by the government. It's actually the only universal healthcare that we have in the US, but it's for an organ, not for a person."
The lead candidate
Hyperphosphatemia is a nearly universal condition for patients with chronic kidney disease (CKD) on dialysis, and a major risk factor for cardiovascular morbidity and mortality. The current treatment for elimination is phosphate binders that work like a sponge absorbing the excess phosphorus, which is then excreted in the faeces.
Raab co-founded Californian company Ardelyx in 2007 after working for years at Genzyme, the developer of phosphate binder Renagel (sevelamer hydrochloride).
Ardelyx aim is to develop and commercialise small molecule therapeutics to treat cardio-renal, GI, and metabolic diseases. The company's lead candidate, Tenapanor, is a targeted, small molecule therapy under FDA review for the control of serum phosphorus in adult patients with chronic kidney disease (CKD) on dialysis.
"The idea when we started Ardelyx was to really look at a novel way of managing serum phosphorus in patients on dialysis," said Raab. "When your kidneys fail, you can no longer eliminate phosphorus from your body. In today's world with processed food, there is a massive amount of phosphorus that comes into all our bodies from what we eat."
"The problem is you need to take handfuls of phosphate binders for it to work, and it has been this way since the 1970s."
Ardelyx's therapy Tenapanor instead targets the surface of the gut where absorption takes place and inhibits sodium hydrogen exchanger 3 (NHE3). This results in a conformational change of the epithelial cell junctions, thereby significantly reducing paracellular uptake of phosphate at the primary pathway of phosphate absorption.
The therapy consists of two tiny pills about the size of a tic-tac which are taken each day. "What we hope is with these smaller pills there is the potential for better efficacy and in the long-term better outcomes for these patients," said Raab. "It's a long project, something that came from a simple idea and is now likely to become reality for these patients."
Clinical & regulatory activity
The company has conducted three Phase 3 clinical trials evaluating the efficacy and safety of Tenapanor for the control of serum phosphorus in adult patients with CKD on dialysis: two monotherapy trials (BLOCK and PHREEDOM) and one dual mechanism trial (AMPLIFY). All trials have met their primary endpoints.
This year, alongside Japanese partner Kyowa Kirin Co., Ltd., Ardelyx presented data at the American Society of Nephrology's (ASN) virtual Kidney Week, from two Phase 2 studies evaluating the efficacy and safety of the therapy in Japanese patients on hemodialysis.
"The studies showed that you could decrease the pill burden on those patients by 80% when you added Tenapanor to their regimen. What we're seeing across the board is that Tenapanor, for a large percentage of patients, can be used as monotherapy, meaning you no longer need binders. You then see a significant number of patients benefiting from a small amount of adjunctive binder use."
According to Raab, the two branded binders currently on the market are not viewed as competition to Tenapanor due to being legacy technologies. While Ardelyx awaits FDA approval for Tenapanor, it is moving forward with regulatory approval internationally and has filed documents with the European Medicines Agency (EMA).
"We've done a number of trials with European subjects, and we need to determine from the EMA if this data is sufficient for approval in the European Union. That's going to be an important thing for us in 2021," explained Raab.
In addition, the company is looking towards other territories as its commercial strategy evolves. "We have a fantastic partnership in Japan, which is a very sizable dialysis market and then a sizable partnership with Fosun Pharma in China, and Knight Pharmaceuticals in Canada. We are seeing all this as a significant global opportunity to help patients, not just in the United States but throughout the world."
Ardelyx
Tempanor
Patient experiences are evolving. How can pharma keep up?


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The Force Of Destiny Tickets
The Force of Destiny Tickets London Coliseum, London
We're sorry, it looks like we no longer have tickets for this event
About The Force of Destiny
From the opening notes of its famous overture, you'll be drawn into The Force of Destiny's powerful score as it follows the entwined destinies of the central characters.
The youthful lovers Leonora and Alvaro have no idea that their feelings for each other will unleash a devastating chain of events as fate takes its inescapable grip on everyone's lives
The Force of Destiny Performance Dates & Times
The Force of Destiny is not available to book, please sign up to our newsletter for updates and offers on forthcoming and available shows.
The Force of Destiny Customer Reviews
Sung in English with lyrics projected above the stage.
Where is The Force of Destiny?
St Martin's Lane London WC2N 4ES
Nearest Bus stop: 24, 29, 176 / 6, 9, 11, 13, 15, 23, 87, 91, 139
Parking: Q-Park: Chinatown (5mins) / Other: St Martin's Lane Hotel (1min)
Nearest Night Bus: 24, 176, N5, N20, N29, N41, N279 / 6, 23, 139, N9, N15, N11, N13, N21, N26, N44, N47, N87, N89, N91, N155, N343, N551
(3mins) Take Cranbourn Street until St Martin's Lane, where you head right until you reach the theatre.


World's largest technology provider hosting company Godaddy has expanded their service with Godaddy cloud hosting. It launches 4th generation web hosting that uses a cloud environment. Godaddy Cloud Servers allow users total control over cloud storage, bandwidth, CPU capacity, and server configuration. But after few time they stopped Godaddy Cloud web hosting service. After then Godaddy starts a business web hosting that known as Data Center on Demand business hosting. It provides high-quality services at a reasonable price. Now, it has been taken the wraps off cloud servers and cloud applications. That will help a company to build, test and scale cloud solutions on Go daddy's infrastructure.
Does Godaddy have cloud storage?
Yes, it has online cloud storage, without any storage limit. So, one can make online backups of large files like videos, photos etc. There is no limit of storage on how many files you can store. And working with online file storage is easy and intuitive that you can use any time stored files when you are using cloud storage.
A lot of additional benefits, users could get with this cloud hosting GoDaddy service.
Godaddy gives 99.9% guaranteed uptime, so could get automatically back-up your data without any downtime.
Provide private networking to maintain secure communication and protocols among user servers.
Supports operating system as Ubuntu 14.04, CentOS 6 & 7, Fedora 23, Debian 8 and Arch Linux.
It can assign multiple permanent IPs to a single server flexible when required.
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Godaddy cloud servers are integrated with cloud applications. This partnership provides one-click installation around 120 applications. Godaddy cloud servers have come with a competition among Amazon and other providers. The newest cloud service of Godaddy is available in 26 languages in 44 countries.


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Ctenoides ales, communément nommé Lime électrique, est une espèce de mollusques bivalves marins de la famille des Limidae.

La Lime électrique est présente dans les eaux tropicales de la zone centrale de l'Indo-Pacifique, soit de l'Indonésie à l'archipel de Palaos en passant par la Nouvelle-Calédonie.

Son nom vernaculaire est lié au phénomène d'"arc électrique" visible lorsque le bivalve est observé. Toutefois selon le L. Dougherty, ce phénomène n'est absolument pas lié à la bioluminescence mais est simplement issu de la réflexion de la lumière ambiante (soleil, torche…) sur les tissus hautement réflectifs de la bordure externe du manteau de l'animal.

Galerie

Notes et références

Liens externes

Limidae


This list falls under the Professionals category which contains a variety of specialist and skilled fields, be they legislative, design orientated, or based on specialist skills and education. For additional lists like this, such as Vets, CPA, or Interior Designers; simply place your search term in the search bar, or navigate using the categories menu on the side of this page.
The accountants list is a broad list that can be utilised for a number of general, and speciality fields; aside from your general business to business (inventory management, first aid/health services, et cetera), there are a number of speciality services that the accounting industry utilises: these include architects, compliance specialists, and fire safety technicians to name a few.


Telstra today announced a major step forward in the development of the Internet of Things (IoT) in Australia with the successful deployment of Narrowband technology in its IoT Network.
Telstra now offers Narrowband coverage in major Australian cities and many regional towns. This is in addition to the around three million square kilometres of Cat M1 IoT coverage Telstra turned on in 2017. Through the Telstra IoT Network, Telstra is the only carrier in Australia and one of the first carriers in the world to offer both Narrowband and Cat M1 IoT technologies.
"These devices will be the centrepiece of the Internet of Things, which involves enabling everyday objects to send and receive data and will transform the way we all live and work in the years ahead.
"This new capability has been delivered as part of our Networks for the Future program, which is a key pillar in the up to $3 billion capital investment Telstra is making over and above business as usual to transform the way we serve customers, digitise our operations, meet the growing demand for data and lay the groundwork for 5G and IoT.
"We've embraced both Cat M1 and Narrowband to give our customers, particularly our enterprise customers in industries like transportation and logistics, mining, manufacturing and agriculture, the opportunity to choose which technology best suits their needs.
"Cat M1 is well suited to applications with data in the 100s of kilobits per second with extended range and long battery life, such as a personal health monitor or a device used to measure vehicle performance. Narrowband is better suited to applications sending even smaller amounts of data and operating with an even longer battery life, such as a moisture sensor or livestock tracking device," said Ms Denholm.
Telstra also announced it had entered into a Smart City partnership with the Tasmanian State Government, the Federal Government, several local Councils and the University of Tasmania to develop and trial new IoT solutions and drive the uptake of IoT in Launceston. Under the agreement an IoT lab will be established in Launceston and Telstra will support the creation of a Tasmanian Agritech Start-up Accelerator.
"For Australia to take advantage of the opportunities offered by IoT technologies like Narrowband we need a vibrant local ecosystem involving technology companies, start-ups, universities and government collaborating on new products and solutions. We are very pleased to be working with all levels of government in Tasmania to leverage our network investments and innovation to establish Launceston as a leading Smart City," said Ms Denholm.
Media contact: Steve Carey General Manager Media, media@team.telstra.com.


It's a sad fact of life, but unfortunately, not all bingo sites have the longevity to outlast the competition. For all the new bingo sites being launched, there's another elsewhere that's giving up the ghost. On this page, we'll give a fitting home to all the sites that have gone the way of the dodo.
Sites (and occasionally whole bingo networks) close for a number of reasons, but usually, it mainly comes down to one thing – profitability. If a site isn't getting punters through the door, and more importantly, offering them an excellent service when they get there, then sites won't stay open too long.
Some bingo networks won't carry sites that fail to supply players to the network pool. In a couple of cases we've seen entire networks die too, although that is more of a rare occurrence than a closing site. Listed below are sites that have closed during our watch.
If you've wound up here after clicking a site link to an external site, then its because that site has closed but we've kept the page live for reference purposes.
Bingo Bonuses & Codes – Info on sign up bonuses for new players.
Online Bingo Reviews – Get info on sites we've tested on your behalf.
July 2011 – Following the phone hacking scandal and the closure of the News Of The World, NOTW Bingo has shut its doors. All players have been transferred to its sister site, Sun Bingo.


I don't know that I am the most risk-taking consultant in the history of the world. Maybe it's just because I am still pretty new at the whole consulting thing, but I guess overall I wonder how much I dare to do risky things.
I can think of one solid example, however: Tuesday I had a session with a client who wanted to brainstorm ideas for her argumentative paper. All the prompt said was "find a topic related to women and then make an argument." Not even kidding--it was so vague. We begain brainstorming and the more we started talking, the more information I found myself adding from my personal background. (Necessary background info: I am an English Major and one of my cognates (I like to think of them as mini-minors) is Women's Studies.) I shared some information, statistics, trends, etc. that I've been taught in my classes, and not only did my client appreciate it, I think it really helped her brainstorming.
I'm not saying that my personal background was crucial to the session, or that I imparted some wisdom that will now guide her to a beautiful and thoughtful thesis. Not at all. But I could have just as easily not noted some things I know about women's rights; I could have just let her talk and not helped her out to the maximum. Maybe it's wimpy, but I think it's something like a risk.


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Controversial Jesuit supports a film about the LGBT community that conflicts with church teachings
Jan 30, 2021 Honey Shortle
a church
Photo: PAP / Jakub Kaczmarczyk
The new movie, which directly questions church teachings about homosexuality, gets full support from controversial Jesuit Father James Martin SJ, author of the pro-gay book Building a Bridge, and The Father. Brian Massengel, active gay.
A Jesuit – editor-in-chief of America Magazine and advisor to the Vatican Department of Communications – posted an abusive picture of Our Lady of Chistuchua on his Twitter account a week ago, defending the right of the gay community to use this symbol, because, as he explains, it contains very few such icons. In his opinion, the colors of the rainbow were added to the Czstochowa icon with respect.
'Wonderfully made'
The latest film "Exquisitely Made", directed by Jewish director Yuval David, who is a homosexual "marries" another man, Catholic Mark McDermott, was appreciated by Father Martin. The film revolves around Catholic members belonging to sexual minorities who feel rejected and excluded from participating in their religion due to their sexual orientation and gender identity.
>>> What does the church really say about homosexuality?
Described as "a complete documentary that explores the challenges and aspirations of LGBTQ + Catholics," it features interviews with Catholic LGBTQ + leaders, including Father Martin and Father. Messengel. David admitted that he interviewed the "heroic nun" Sister Jenin Gramick, who has served LGBTQ people since 1977. "Co-founder of the Pseudo-Catholic Organization, the Ministry of New Roads received a warning in 1991 from the Vatican to stop working with homosexuals because it" does not transmit With sincerity the clear and consistent teachings of the Catholic Church "regarding" the essential evil of homosexual acts and the objective disturbance of homosexuality ".
See also The beginning of the school year. Fixed education in schools. Health Minister Adam Nidzelsky
>>> United States of America: "Discovery" will release "Francesco" this Palm Sunday
Photo by pixabay.com
Father Martin: Jesus used to go to gays
In the film, Father Martin reiterates his previous belief that "if Jesus lived today, in the flesh, on earth, he will first go to homosexuals." As for Jesus, there is no difference between us and them. "There is only us."
Father Martin, who believes that the requirement that bachelors live in a clean way is not binding on homosexuals, faced much criticism after January 19 of this year. He posted on his Twitter account a modified photo of the painting Lady Chestuchova, depicting Mary and her son with a rainbow-colored halo. A columnist signed the photo, stating: "The LGBT community has very few of these photos. No wonder they added their own symbol, rainbow, respectfully, to their beloved mother's picture."
A priest who many accuse him of preaching the so-called "How very appropriate is it to cry because her son suffers every time a gay person is persecuted" wrote a priest who many accuse. homogeneous.
Honey Shortle
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The World Cup qualifiers are not at PGE Narodowy. A change of location was necessary – Poland national football team – Sport Wprost
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The modernization of the railway station in Rozwadów . is approaching
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There's plenty of NFL news, so Zach and Jake dive into it and help you prepare for your fantasy football drafts. They also discuss Jim Tomsula's beer advice that will change your life (46:00) and rate the top-10 stadium foods for this NFL season (51:37). Also, we're not finished with you, Bills Mafia!
Use promo code 'FlurrySports' for free $3 entry!


Andy has over 20 years experience in handling professional liability claims in the Lloyd's and London insurance market. He began his career in 1994 as a claims broker at Minet (now Aon) focussing on the Big 6 accountants firms and law firms. In 2001, he moved to Wellington Syndicate 2020 to become a claims underwriter on the professional liability portfolio. 2 years later, he then moved to Liberty Mutual as a senior claims underwriter in their professional liability claims unit. In 2005, he joined Brit as a senior claims adjuster focussing on all forms of professional lines, financial institutions and directors & officers liability in the US. During his time at Brit, he was made the Professional Lines Claims Manager responsible for a team handling all forms of professional liability on a global basis. Andy joined Pioneer in May 2014 as Head of Professional Lines working closely with the underwriting teams.


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How To Find Someone's Snapchat Password
admin@freephonespysoftware.com
3 ways to obtain the Snapchat password of someone else's Snapchat password
As quickly Snapchat has expanded in the current world, it has become very accessible to anyone with an iPhone to utilize the popular social media app. Snapchat is available to teenagers which is a danger to their growth. As an adult, you'll be concerned about your kid's safety on Snapchat and would like to know how to find the Snapchat password. By getting your kid's Snapchat password, you can either block them out of Snapchat or look at their Snapchat activity to make sure they're not doing anything illegal. In this article, we will tell you different ways on how to get someone's Snapchat password.
Part 1. 2 Methods to Get Snapchat Password [No Surveys1 Method to Get Snapchat Password (No Survey)
Part 2. Part 2. Common Way to Get Snapchat Passwords of Others [using Survey– Part 2]
Part 1. Two Ways to Get Snapchat Password for Someone [No Survey]
Method 1. The Most Effective Method to Get Snapchat Password of Someone Without Human Verification
Snespy requires you to fill out surveys. This will require you to divulge sensitive information. So, a safer way will be to use FreePhoneSpy to spy on people's Snapchat without telling them. FreePhoneSpy allows you to track your phone's activity. If you're looking to find out how to obtain the Snapchat password in order to spy on their Snapchat or other social media accounts, there's no need for all the hassle when you're using FreePhoneSpy. It is only compatible with Android devices since they support the Keylogger feature as well as Snapchat spying. Furthermore, using FreePhoneSpy to spy on Snapchat Snapchat spy is more secure than hacking the password of someone's Snapchat using fake and unreliable tools.
Why Recommend this? Snapchat Password Hacker:
FreePhoneSpy allows you to spy on Snapchat and other social media activities.
– It is possible to hack the call logs and contacts of the target.
FreePhoneSpy Snapchat spy software can also be utilized to monitor messages in text that were sent or received on the device being targeted.
It is possible to check your history on your browser as well as the local information for the desired.
Keyloggers in FreePhoneSpy can assist you in cracking the Snapchat password for your Snapchat account.
Method 2. SnapHackMaster – Get the person's Snapchat password
SnaphackMaster allows you to quickly access the account of someone else's Snapchat account and retrieve their password. The tool is completely free , and you don't need to fill out any forms for hacking Snapchat password. The online tool is also free and doesn't need you to fill out surveys. It is available for both Android and iPhone to hack Snapchat. Follow the below steps for how to obtain the user's Snapchat password by using SnapHackMaster.
Step 1: Go to http://www.snaphackmaster.com/ and then click on Hack Snapchat button.
Step 2: Now , enter the Snapchat username and password of the target. Select what you want to hack, such as chat logs, passwords or chat history.
Step 3: Choose the media content that you wish to download. Also, select the date from which you'd like to download Snapchat logs
Step 4: Select whether you'd like to download these files in a Zip file, or in a single file. Click the "I I Agree to Continue" button and then wait for the Snapchat account password hacker's process to begin.
Part 2. The Common Way to Get Someone's Snapchat Password [with Survey]
Snespy is the most well-known method used by people to hack into someone's Snapchat password. Snespy is an online tool which allows users to hack Snapchat accounts at no cost, requires you to complete several surveys before you can access the Snapchat password. There's a different online Snapchat hacking tool, like Snapch or heyblink that works the same as Snespy to hack someone's Snapchat password. If you want to hack someone's Snapchat password, follow these steps using Snespy.
Here are some easy ways to obtain the Snapchat password
Step 1. Go to http://snespy.com/online/ in a web browser. Log in with the username and password for the target individual.
Step 2. Step 2.
Snapchat is the fastest-growing social media platform. Every day millions of snaps and photos are shared on Snapchat. Teenagers are spending the majority of their time on Snapchat or other social media platforms, parents want to know how they can get an individual's Snapchat password so they can log into their kid's Snapchat account and check their Snapchat activities. Below we've discussed several methods to spy on someone else's Snapchat activities. In all of the ways, FreePhoneSpy is the most trustworthy tool to track an individual's Snapchat or to get their password.
Visit this website to know more about How To Find Someone's Snapchat Password at: freephonespy.net/hack-snapchat-messages-without-phone/
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Hack Snapchat Pictures with The Most Easiest Way Are you seeking ways to hack Snapchat pictures? There are many methods to hack Snapchat images. Snapchat is a social media app that allows you to post photos and engage...
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Today I have my last day of law school class ever. I went straight from college to law school, so I've been in school for the past 22 years straight. It's crazy for me to realize that I will never take another class in school again. It's been a whirl-wind last few weeks, and it will continue to be a whirl-wind until finals are over and graduation rolls around. In the past few weeks my classmates have realized that we won't all be together for very much longer, so we've been trying to cram in as much fun, social outings as we can while still juggling starting to study for finals. Some of us are sticking around the Durham area for the summer to study for the Bar Exam, while some of us are going home for the summer or moving to our new cities a few months early. After consistently being in school for the last 22 years, I'm looking forward to entering the working world this fall.
One of my closest law school friends and I decided to do a little photo shoot to commemorate the last day of classes. The law school sign is a favorite spot to take pictures, but somehow I had made it three years without any pictures with the sign, so I needed to rectify that. It was the perfect spring day for a photo shoot. The temperature was in the mid 70's and there was a light breeze. I had on my favorite spring jacket, my scalloped trench coat from Draper James, but I really didn't need it, it was so nice out. I love the scallop details around the waistline and the 3/4 length sleeves on this jacket. It's perfect for spring and early fall.
My chambray top is also from Draper James, I love their spring line this year. They have lots of timeless silhouettes and classic fabrics. This top is so soft and comfortable, the chambray material is great. I love that the ruffled sleeves add a bit of fun and feminine flair to an otherwise simple top, and the high v-neck is perfect for wearing a pendant necklace with it. I paired the top with white jeans, but it would also look great with black pants, or patterned shorts or a skirt. It's such a versatile top that goes with pretty much everything besides blue denim.
I'm obsessed with the white jeans that I'm wearing. They're from the Loft and they're the signature curvy fit. The Loft's curvy fit is great for anyone with an hourglass figure. I had when pants that fit in the thighs and hips end up gaping a ton at the waist, or when pants that fit in the waist are squeezing the life out of my thighs. These pants are designed to fix that problem, and they do a great job. The fit my waist and hips with no gaping or squeezing. They're also a thick enough material that you can't see through the white denim at all. I hate when you can see the outline of the pockets through white pants, and these don't show anything.
My favorite part of this outfit though, was my earrings. I've said before that I find Kate Spade's novelty lines to be pretty hit or miss, but I absolutely love these bee earrings. They're perfect for spring and summer. When I was considering buying them I showed them to my fiance and he told me that I should get them and where them "whenever we're drinking on a roof or patio this summer." They're so whimsical and fun, but the colors are neutral enough that you can wear them with a lot of different outfits.


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Marc Camille Chaimowicz
Pendulum Polaroids, 2000
Marc Camille Chaimowicz, Pendulum Polaroids, 2000
Marc Camille Chaimowicz, Pendulum Polaroids, 2000, Polaroid photographs
Pendulum Polaroids is part of a body of work, the Pendulum Project, developed during the artist's visiting fellowship at the Maison Française, Oxford in 1997. The title of the work alludes to a state of perpetual movement between one place and another and reflects the artist's dual citizenship, based in Camberwell, London, and Dijon, France.
The work is composed of 143 Polaroid photographs taken over a two-week period in London and Paris. Photographed in quick succession, the images convey the fluidity of movement of the flaneur, capturing incidental details of city life that shift in and out of focus. Arranged in various configurations, collectively the work conveys aspects of formal and cultural correspondence and difference.
Polaroid photographs
56 sets, 143 images
PT2068 – PT2076
Purchased through the Contemporary Art Society Special Collection Scheme with Lottery funding from Arts Council England, 2001


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Partial Resuscitative Endovascular Balloon Occlusion of the Aorta in Swine Model of Hemorrhagic Shock
Rachel M. Russo, Lucas P. Neff, Christopher M. Lamb, Jeremy W. Cannon, Joseph M Galante, Nathan F. Clement, J. Kevin Grayson, Timothy K. Williams
Trauma, Acute Care Surgery, & Surgery Critical Care
Background Complete resuscitative endovascular balloon occlusion of the aorta (C-REBOA) increases proximal mean arterial pressure (MAP) at the cost of distal organ ischemia, limiting the duration of intervention. We hypothesized that partial aortic occlusion (P-REBOA) would maintain a more physiologic proximal MAP and reduce distal tissue ischemia. We investigated the hemodynamic and physiologic effects of P-REBOA vs C-REBOA. Study Design Fifteen swine were anesthetized, instrumented, splenectomized, and subjected to rapid 25% blood volume loss. They were randomized to C-REBOA, P-REBOA, or no intervention (controls). Partial REBOA was created by partially inflating an aortic balloon catheter to generate a 50% blood pressure gradient across the balloon. Hemodynamics were recorded and serum makers of ischemia and inflammation were measured. After 90 minutes of treatment, balloons were deflated to evaluate the immediate effects of reperfusion. End organs were histologically examined. Results Complete REBOA produced supraphysiologic increases in proximal MAP after hemorrhage compared with more modest augmentation in the P-REBOA group (p < 0.01), with both groups significantly greater than controls (p < 0.01). Less rebound hypotension after balloon deflation was seen in the P-REBOA compared with C-REBOA groups. Complete REBOA resulted in higher serum lactate than both P-REBOA and controls (p < 0.01). Histology revealed early necrosis and disruption of duodenal mucosa in all C-REBOA animals, but none in P-REBOA animals. Conclusions In a porcine hemorrhagic shock model, P-REBOA resulted in more physiologically tolerable hemodynamic and ischemic changes compared with C-REBOA. Additional work is needed to determine whether the benefits associated with P-REBOA can both extend the duration of intervention and increase survival.
Journal of the American College of Surgeons
https://doi.org/10.1016/j.jamcollsurg.2016.04.037
Balloon Occlusion
Hemorrhagic Shock
Russo, R. M., Neff, L. P., Lamb, C. M., Cannon, J. W., Galante, J. M., Clement, N. F., ... Williams, T. K. (2016). Partial Resuscitative Endovascular Balloon Occlusion of the Aorta in Swine Model of Hemorrhagic Shock. Journal of the American College of Surgeons, 223(2), 359-368. https://doi.org/10.1016/j.jamcollsurg.2016.04.037
Partial Resuscitative Endovascular Balloon Occlusion of the Aorta in Swine Model of Hemorrhagic Shock. / Russo, Rachel M.; Neff, Lucas P.; Lamb, Christopher M.; Cannon, Jeremy W.; Galante, Joseph M; Clement, Nathan F.; Grayson, J. Kevin; Williams, Timothy K.
In: Journal of the American College of Surgeons, Vol. 223, No. 2, 01.08.2016, p. 359-368.
Russo, RM, Neff, LP, Lamb, CM, Cannon, JW, Galante, JM, Clement, NF, Grayson, JK & Williams, TK 2016, 'Partial Resuscitative Endovascular Balloon Occlusion of the Aorta in Swine Model of Hemorrhagic Shock', Journal of the American College of Surgeons, vol. 223, no. 2, pp. 359-368. https://doi.org/10.1016/j.jamcollsurg.2016.04.037
Russo RM, Neff LP, Lamb CM, Cannon JW, Galante JM, Clement NF et al. Partial Resuscitative Endovascular Balloon Occlusion of the Aorta in Swine Model of Hemorrhagic Shock. Journal of the American College of Surgeons. 2016 Aug 1;223(2):359-368. https://doi.org/10.1016/j.jamcollsurg.2016.04.037
Russo, Rachel M. ; Neff, Lucas P. ; Lamb, Christopher M. ; Cannon, Jeremy W. ; Galante, Joseph M ; Clement, Nathan F. ; Grayson, J. Kevin ; Williams, Timothy K. / Partial Resuscitative Endovascular Balloon Occlusion of the Aorta in Swine Model of Hemorrhagic Shock. In: Journal of the American College of Surgeons. 2016 ; Vol. 223, No. 2. pp. 359-368.
@article{db644b0e33ef44df97e84f564ebd4469,
title = "Partial Resuscitative Endovascular Balloon Occlusion of the Aorta in Swine Model of Hemorrhagic Shock",
abstract = "Background Complete resuscitative endovascular balloon occlusion of the aorta (C-REBOA) increases proximal mean arterial pressure (MAP) at the cost of distal organ ischemia, limiting the duration of intervention. We hypothesized that partial aortic occlusion (P-REBOA) would maintain a more physiologic proximal MAP and reduce distal tissue ischemia. We investigated the hemodynamic and physiologic effects of P-REBOA vs C-REBOA. Study Design Fifteen swine were anesthetized, instrumented, splenectomized, and subjected to rapid 25{\%} blood volume loss. They were randomized to C-REBOA, P-REBOA, or no intervention (controls). Partial REBOA was created by partially inflating an aortic balloon catheter to generate a 50{\%} blood pressure gradient across the balloon. Hemodynamics were recorded and serum makers of ischemia and inflammation were measured. After 90 minutes of treatment, balloons were deflated to evaluate the immediate effects of reperfusion. End organs were histologically examined. Results Complete REBOA produced supraphysiologic increases in proximal MAP after hemorrhage compared with more modest augmentation in the P-REBOA group (p < 0.01), with both groups significantly greater than controls (p < 0.01). Less rebound hypotension after balloon deflation was seen in the P-REBOA compared with C-REBOA groups. Complete REBOA resulted in higher serum lactate than both P-REBOA and controls (p < 0.01). Histology revealed early necrosis and disruption of duodenal mucosa in all C-REBOA animals, but none in P-REBOA animals. Conclusions In a porcine hemorrhagic shock model, P-REBOA resulted in more physiologically tolerable hemodynamic and ischemic changes compared with C-REBOA. Additional work is needed to determine whether the benefits associated with P-REBOA can both extend the duration of intervention and increase survival.",
author = "Russo, {Rachel M.} and Neff, {Lucas P.} and Lamb, {Christopher M.} and Cannon, {Jeremy W.} and Galante, {Joseph M} and Clement, {Nathan F.} and Grayson, {J. Kevin} and Williams, {Timothy K.}",
doi = "10.1016/j.jamcollsurg.2016.04.037",
journal = "Journal of the American College of Surgeons",
T1 - Partial Resuscitative Endovascular Balloon Occlusion of the Aorta in Swine Model of Hemorrhagic Shock
AU - Russo, Rachel M.
AU - Neff, Lucas P.
AU - Lamb, Christopher M.
AU - Cannon, Jeremy W.
AU - Galante, Joseph M
AU - Clement, Nathan F.
AU - Grayson, J. Kevin
AU - Williams, Timothy K.
N2 - Background Complete resuscitative endovascular balloon occlusion of the aorta (C-REBOA) increases proximal mean arterial pressure (MAP) at the cost of distal organ ischemia, limiting the duration of intervention. We hypothesized that partial aortic occlusion (P-REBOA) would maintain a more physiologic proximal MAP and reduce distal tissue ischemia. We investigated the hemodynamic and physiologic effects of P-REBOA vs C-REBOA. Study Design Fifteen swine were anesthetized, instrumented, splenectomized, and subjected to rapid 25% blood volume loss. They were randomized to C-REBOA, P-REBOA, or no intervention (controls). Partial REBOA was created by partially inflating an aortic balloon catheter to generate a 50% blood pressure gradient across the balloon. Hemodynamics were recorded and serum makers of ischemia and inflammation were measured. After 90 minutes of treatment, balloons were deflated to evaluate the immediate effects of reperfusion. End organs were histologically examined. Results Complete REBOA produced supraphysiologic increases in proximal MAP after hemorrhage compared with more modest augmentation in the P-REBOA group (p < 0.01), with both groups significantly greater than controls (p < 0.01). Less rebound hypotension after balloon deflation was seen in the P-REBOA compared with C-REBOA groups. Complete REBOA resulted in higher serum lactate than both P-REBOA and controls (p < 0.01). Histology revealed early necrosis and disruption of duodenal mucosa in all C-REBOA animals, but none in P-REBOA animals. Conclusions In a porcine hemorrhagic shock model, P-REBOA resulted in more physiologically tolerable hemodynamic and ischemic changes compared with C-REBOA. Additional work is needed to determine whether the benefits associated with P-REBOA can both extend the duration of intervention and increase survival.
AB - Background Complete resuscitative endovascular balloon occlusion of the aorta (C-REBOA) increases proximal mean arterial pressure (MAP) at the cost of distal organ ischemia, limiting the duration of intervention. We hypothesized that partial aortic occlusion (P-REBOA) would maintain a more physiologic proximal MAP and reduce distal tissue ischemia. We investigated the hemodynamic and physiologic effects of P-REBOA vs C-REBOA. Study Design Fifteen swine were anesthetized, instrumented, splenectomized, and subjected to rapid 25% blood volume loss. They were randomized to C-REBOA, P-REBOA, or no intervention (controls). Partial REBOA was created by partially inflating an aortic balloon catheter to generate a 50% blood pressure gradient across the balloon. Hemodynamics were recorded and serum makers of ischemia and inflammation were measured. After 90 minutes of treatment, balloons were deflated to evaluate the immediate effects of reperfusion. End organs were histologically examined. Results Complete REBOA produced supraphysiologic increases in proximal MAP after hemorrhage compared with more modest augmentation in the P-REBOA group (p < 0.01), with both groups significantly greater than controls (p < 0.01). Less rebound hypotension after balloon deflation was seen in the P-REBOA compared with C-REBOA groups. Complete REBOA resulted in higher serum lactate than both P-REBOA and controls (p < 0.01). Histology revealed early necrosis and disruption of duodenal mucosa in all C-REBOA animals, but none in P-REBOA animals. Conclusions In a porcine hemorrhagic shock model, P-REBOA resulted in more physiologically tolerable hemodynamic and ischemic changes compared with C-REBOA. Additional work is needed to determine whether the benefits associated with P-REBOA can both extend the duration of intervention and increase survival.
U2 - 10.1016/j.jamcollsurg.2016.04.037
DO - 10.1016/j.jamcollsurg.2016.04.037
JO - Journal of the American College of Surgeons
JF - Journal of the American College of Surgeons
10.1016/j.jamcollsurg.2016.04.037


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A year after losing their son to leukemia, the Gilkey family finds solace in memories - and a fund for future research.
Most nights Laura Gilkey stays up a few minutes past midnight.
That's when Facebook changes its feed, to include a memory from that day in a previous year. It's a chance for Gilkey to virtually re-connect with her son, Benjamin Gilkey. He's affectionately known as Benji — and through more than two years battling leukemia, Benji the Brave. Benji Gilkey died Feb. 11, 2017, less than two months after he turned 9 years old.
The Benjamin Gilkey Fund for Innovation Pediatric Research has hosted multiple fundraisers and events in the past year. Including donations outside events, the fund has raised nearly $300,000.
An upcoming fundraising event for the fund is the 2018 Johns Hopkins All Children's Hospital Invitational "Pack the Tent." The event, hosted by Cathy and Eric Kobren, is scheduled for Monday, Feb. 19 at the Concession Golf Club in east Manatee County, 7700 Lindrick Lane, Bradenton.
At the event, noted British golfer Tony Jacklin will join Michael and Laura Gilkey, whose son, Benjamin, died from leukemia in 2017, in sharing their Johns Hopkins All Children's Hospital stories. The event begins at 6 p.m. Tickets are $175 a person and $1,400 for a table of eight. For information, contact Brittany Fox at 770-551- 0300 or [email protected].
Those wishing to donate to the fund can do so online, at giveto.hopkinsallchildrens.org/benjamingilkeyfund.
Those memories could be a black and white profile photo of just Benji, hair flowing with a wide smile. Some are goofball posed photos in a hospital room.
One is a video of Tampa Bay Buccaneers players visiting children in Johns Hopkins All Children's Hospital in St. Petersburg.
But Gilkey does more than look back. She also looks forward, partially for the Benjamin Gilkey Fund for Innovation Pediatric Research she and her family launched in Benji's honor. Laura Gilkey, 41, also looks forward for her husband, Michael Gilkey, 43, and the couple's 13-year-old son, Banyan.
Laura Gilkey, by promoting and supporting the fund, and through an uncommonly raw blog (benjaminthebrave.com/blog) where she writes, also has been thrust into the spotlight in Sarasota. While the Gilkeys are far from the only family in Sarasota — or anywhere else — to lose a child to illness, her graceful blog posts have resonated with people locally and nationwide. Gilkey has heard from hundreds, if not thousands, of people on the blog.
Benji's diagnosis and treatment evolved over more than two years. It started as a common childhood cancer, Pre-B Cell Acute Lymphoblastic Leukemia. During treatment, the family and doctors discovered he had a rare predisposition for Constitutional Mismatch Repair Deficiency, which was essentially responsible for the leukemia. There's only been some 150 reported cases of Constitutional Mismatch Repair Deficiency.
Benji's school, Southside Elementary, where he was in third grade, rallied around the Gilkey family during the years he was sick. In an odd twist, the school had a second student battling cancer, first-grader Avery Rann, around the same time Benji was in his fight. Avery Rann died May 11. She was 7 years old.
Avery Rann's father, Russ Rann, says the school's network of support was a comfort during a difficult time. A Sarasota native who only moved his family to the Southside district a few years ago, says it was divine intervention that brought his family there. Support included meal trains, ribbons on trees and just random acts of comfort for the whole family. Laura Gilkey says her family also benefited from the extended support at Southside.
Memories of Benji for Laura Gilkey remain fresh at Southside. Soon after Benji died, on her way to drop some papers off, she recalls, she walked past another mom. The mom burst into tears seeing Gilkey, standing on the sidewalk in front of the school. "It's really hard for people to know what to say," Gilkey said.
Benji kept his wide smile even as he went through chemotherapy.
Such as the time, around last Christmas, when the family found an ornament that reminded them of Benji. Michael and Laura Gilkey fought back tears. Bayan smiled, thinking of his brother.
The Benjamin Gilkey Fund for Innovation Pediatric Research also keeps Gilkey busy. The target: research in the fields of genetic predispositions, immunotherapy and toxicity to chemotherapy, all factors in Benji's cancer. It has raised more than $280,000 through Feb. 1, and the first proposal for a research study is currently under review at the hospital.


For his work using high-resolution synchrotron-based tomography techniques to develop a fundamental understanding of the mechanical and multifunctional design of biological materials.
For outstanding contributions in developing phase-retrieval methods and applying phase-contrast in vivo microtomography to probe embryonic development.
For outstanding structural and functional studies of the influenza virus envelope glycoprotein hemagglutinin (HA) to understand how our immune system can broadly neutralize the virus through interaction with the HA and prevent viral fusion.
For furthering understanding of itinerant magnetism and for contributions to the study of quantum matter at high pressure using synchrotron x-ray diffraction.
For applying challenging surface and coherent x-ray scattering techniques to understanding the structure and dynamics of liquid metal surfaces and quantum states in condensed matter systems.
2006 Wendy L. Mao For applying novel x-ray techniques that permit the study of light-element speciation at high pressure and for innovative experimental approaches to studying mineral physics at conditions of the Earth's deep interior.
of basaltic glasses in deep ocean environments.


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