text:
Year Twelve Topic One Essay
1. Distinguish between inertial and non-inertial frames of reference.
Frames of reference are coordinate systems or objects with respect to which we take measurements. (1)
A non-inertial frame of reference is one that is accelerating with fictitious or inertial forces. In these frames observers have to predicate the existence of these 'forces' to maintain the validity of Newton's laws.
An inertial frame of reference is one that is moving with constant velocity or is it at rest, holding Newton's first law of Inertia. No frame is more correct then another, however, some are simpler. An example could be the stars.(2)
2. Analyse the changing acceleration of a rocket during launch in ...view middle of the document...
Hence the forces on the astronauts increase. The g-forces increase as minimal friction occurs when the density of the atmosphere decreases with the increasing height of the rocket. (5)
3. Discuss the importance of Newtons law of universal gravitation in understanding and calculating the motion of satellites
Simplistically Newton's Law of Universal Gravitation is that an object attracts every other object in the universe and the two factors that determine the force of the attraction are:
1. The mass of each of the two objects
2. The distances between their centres of mass.
Represented mathematically by:
where, F = force of attraction between objects
G = universal gravitational constant (which is equal to 6.67 x 10-11 N m2 kg-2)
m1 = mass of object 1
d = distance between their centres of mass. (6)
Gravitation provides the centripetal force that produces the circular motion that is the satellite's orbit around a planet. Therefore, it can be said that:
Gravitational force = Centripetal force
A planet revolving around the sun in a circular orbit or radius r, the centripetal force is provided by the gravitational attraction between the planet and the sun. If the mass of the planet is m and the mass of the sun is M, then:
The following expressions can be derived, from the relationships described in the information above:
The second equation describes the relationship between the radius of an orbit and the period for any (and all) satellites, natural and artificial, orbiting the earth and planets and comets orbiting the sun. It is also Kepler's third law known as Keplers Law of Periods a necessary consequence of Newton's Law of Universal Gravitation. (7)
4. Describe how the slingshot effect provides greater speed for space probes
The slingshot effect is also known as a planetary swing by or a gravity-assist manoeuvre. It is performed to achieve an increase in speed and/or a change of direction.
A spacecraft is aimed close to a planet. As it approaches, the spacecraft is caught by the gravitational field of the planet, and swings around it. The speed acquired is then sufficient to throw the spacecraft back out again, away from the planet. By controlling the approach, the outcome of the manoeuvre can be manipulated.
As the probe approaches a planet it is accelerated by the gravitational attraction of the planet, causing it to speed up relative to the planet. As the probe passes the planet, its speed is reduced ,however, relative to the sun, its speed has increased. The probe picks up angular momentum from the planet as it loses an equal amount. (8)
5. Outline the features of the aether model for the transmission of light
The ancient Greeks spoke of the earth as being surrounded by water, then air and...
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Read Margaret's own account of surviving "flesh-eating disease"
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Q: Why is this program inserting the values in the message table everytime the page gets reloaded? This is the code for a simple chatting system using php, mysql, html, css and javascript. The problem with this code is the everytime the user enters a message and pressed the send button, the message gets send and the value is inserted into the message table but when we refresh the page, the same message again and the message is again inserted into the database. I've tried to manage the architecture but the problem doesn't solve.
Here is my code.

<link rel="stylesheet" type="text/css" href="chat.css">
</link>

<?php
session_start();
include 'ConnectionPDO.php';
//include_once 'chat.html';
$_SESSION["person"]=$_GET["person"];
if(isset($_SESSION['username'])){

if(isset($_POST['btn'])){
     $message=$_POST['msg'];
     $person=$_GET['person'];
    try {
    $stmt = $dbh->prepare("INSERT INTO `messages` (`id`, `sendby`, `sento`, `date/time`, `seen`, `active`, `message`) VALUES (NULL, ?, ?, CURRENT_TIMESTAMP, 'No', 'No', ?)");
    $stmt->bindParam(1,$_SESSION['username']);
    $stmt->bindParam(2,$person);
    $stmt->bindParam(3,$message);
    $stmt->execute();
        if($stmt) {
            echo "
";
            echo "Message sent!";
        }
    }
    catch (PDOException $e) {
        echo $e->getMessage();
    }

    }
}else{

}
?>

<?php
$_SESSION["person"]=$_GET["person"];

try {
        $stmt2 = $dbh->prepare("select * from `messages` where (`sendby`=? AND `sento`=?) OR (`sendby`=? AND `sento`=?)");
        $stmt2->bindParam(1, $_SESSION['username']);
        $stmt2->bindParam(2, $_SESSION["person"]);
        $stmt2->bindParam(3, $_SESSION["person"]);
        $stmt2->bindParam(4, $_SESSION['username']);
        $stmt2->execute();

        while($row=$stmt2->fetch()) {
         $sento= $row['sendby'];
         $message= $row['message'];
         $time= $row['date/time'];
         echo $sento;
        echo "
";
        echo $message;
        echo "
";
        echo $time;
        echo "
";
        echo "
";
        }
    }
    catch (PDOException $e) {
        echo $e->getMessage();
    }

?>

<form method="post">
<input type="text" name="msg" placeholder="Enter your message here" id="msg">

<input type="submit" value="Send" name="btn" id="btn">
</form>

A: This happens when your front end(HTML, CSS) and backend(PHP and MySQL/PDO queries) On the same page. Better you can use front end to insert the details and send it to the backend in other PHP files and redirect the result status to front end file by ajax/header/cookies etc.

redpajama_set_name: RedPajamaStackExchange


The heart was supposed to leave the plane in Seattle.
Don't get too excited about Lyft and Southwest working together.
Save during your perfect trip this summer.
This kind of accident is "almost unheard of."
"All Americans are entitled to peacefully exercise their religious beliefs."
The airline had been using back-up systems around the country to check in travelers.
A Southwest Airlines flight aborted takeoff at Chicago's Midway International Airport late Wednesday night due to a mechanical issue, the airline said.
Plane tickets for under $100? If that deal seems too good to be true, that's because it is.
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We talked to Southwest's CMO Kevin Krone about the company's recent rebrand and the state of marketing in 2015.
Southwest canceled at least 80 flights as a result.
Injuries from falling luggage may be more common than you think.
Southwest has now completely absorbed the carrier.
The airline is expanding its international routes, beginning in October 2015.
A woman gave birth on a Southwest Airlines flight on Tuesday, prompting the crew to divert the flight from its original destination, Phoenix, to Los Angeles.
JetBlue's decision to charge for bags is an opportunity for Southwest.
The service will be free on Wi-Fi enabled flights.
For one, an opportunity to grow. For the other, an experiment.
Southwest is now flying internationally to destinations in Mexico and the Caribbean.
Southwest Airlines ranks near the bottom of airlines' on-time arrivals, but it's working on improving its performance by the end of the year.


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Former First Lady Nancy Reagan dies at 94 in California
March 11, 2016 Category: Week In Review Posted by: Philadelphia Sun Staff
ABOVE PHOTO: Nancy Reagan (s_bukley / Shutterstock.com)
By Christopher Weber
LOS ANGELES — Nancy Reagan, the helpmate, backstage adviser and fierce protector of Ronald Reagan in his journey from actor to president – and finally during his 10-year battle with Alzheimer's disease, has died. She was 94.
The former first lady died last Sunday at her home in the Bel-Air section of Los Angeles of congestive heart failure, assistant Allison Borio told The Associated Press.
Her best-known project as first lady was the "Just Say No" campaign to help kids and teens stay off drugs.
In announcing his Alzheimer's diagnosis in 1994, Reagan wrote, "I only wish there was some way I could spare Nancy from this painful experience." Ten years later, as his body lay in state in the U.S. Capitol, Mrs. Reagan caressed and gently kissed the flag-draped casket.
She met Ronald Reagan in 1950, when he was president of the Screen Actors Guild and she was seeking help with a problem: Her name had been wrongly included on a published list of suspected communist sympathizers. They discussed it over dinner, and she later wrote that she realized on that first blind date "he was everything that I wanted."
They wed two years later, on March 4, 1952. Daughter Patti was born in October of that year and son Ron followed in 1958. Reagan already had a daughter, Maureen, and an adopted son, Michael, from his marriage to actress Jane Wyman.
Former first lady Barbara Bush dies at age 92 The Reagan I remember Reagan was no friend of Blacks

redpajama_set_name: RedPajamaCommonCrawl


There were civilians standing around, there was no one firing at the American soldiers, and at least two people had cameras. There may have been people armed, as are many in the United States, but this does not create the license to fire on people. That is one violation of the Geneva Conventions - targeting civilians who do not pose a threat, not for military necessity.
The second and third possible violations of the laws of war are evident in the scene on the tape when the van attempts to rescue the wounded, and a later scene of a U.S. tank rolling over a body on the ground. The soldiers shot the rescuer and those in the van, another possible violation of the Geneva Conventions - preventing the rescue. Third, when the wounded or dead man was lying on the ground, a U.S. tank rolled over him, effectively splitting him in two. If he was dead, that amounted to disrespecting a body, another violation of the Geneva Conventions.
Steiber explained that during his basic training for the military, "We watched videos celebrating death," and said that his commanders would "pull aside soldiers who'd not deployed, and ask us if somebody open fired on us in a market full of unarmed civilians, would we return fire. And if you didn't say 'yes' instantly, you got yelled at for not being a good soldier. The mindset of military training was one based on fear, and the ability to eliminate any threat."
Marjorie Cohn, a professor at Thomas Jefferson School of Law and immediate past president of the National Lawyers Guild, is the deputy secretary general for external communications of the International Association of Democratic Lawyers, and the U.S. representative to the executive committee of the American Association of Jurists. See www.marjoriecohn.com.


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TI Home > Semiconductors > Amplifiers > Operational amplifiers (op amps) > Precision op amps (Vos<1mV) >
TLC27L9 (ACTIVE) Quad Precision Single Supply Micropower Operational Amplifier
LinCMOS Precision Quad Operational-Amplifiers datasheet (Rev. C)
Recommended alternative parts
OPA4241 - The device has SIMILAR FUNCTIONALITY but is not functionally equivalent to the compared device. For wider supply range(2.7V-36V), lower offset voltage (250µV max), and lower drift(0.4µV/°C), upgrade to OPA4241.
The TLC27L4 and TLC27L9 quad operational amplifiers combine a wide range of input offset voltage grades with low offset voltage drift, high input impedance, extremely low power, and high gain.
These devices use Texas instruments silicon-gate LinCMOSTM technology, which provides offset voltage stability far exceeding the stability available with conventional metal-gate processes.
The extremely high input impedance, low bias currents, and low-power consumption make these cost-effective devices ideal for high-gain, low- frequency, low-power applications. Four offset voltage grades are available (C-suffix and I-suffix types), ranging from the low-cost TLC27L4
(10 mV) to the high-precision TLC27L9 (900 uV). These advantages, in combination with good common-mode rejection and supply voltage rejection, make these devices a good choice for new state-of-the-art designs as well as for upgrading existing designs.
In general, many features associated with bipolar technology are available on LinCMOSTM operational amplifiers, without the power penalties of bipolar technology. General applications such as transducer interfacing, analog calculations, amplifier blocks, active filters, and signal buffering are easily designed with the TLC27L4 and TLC27L9. The devices also exhibit low voltage single-supply operation and ultra-low power consumption, making them ideally suited for remote and inaccessible battery-powered applications. The common-mode input voltage range includes the negative rail.
A wide range of packaging options is available, including small-outline and chip-carrier versions for high-density system applications.
The device inputs and outputs are designed to withstand -100-mA surge currents without sustaining latch-up.
The TLC27L4 and TLC27L9 incorporate internal ESD-protection circuits that prevent functional failures at voltages up to 2000 V as tested under MIL-STD-883C, Method 3015.2; however, care should be exercised in handling these devices, as exposure to ESD may result in the degradation of the device parametric performance.
The C-suffix devices are characterized for operation from 0°C to 70°C. The I-suffix devices are characterized for operation from -40°C to 85°C. The M-suffix devices are characterized for operation from -55°C to 125°C.
The D package is available taped and reeled. Add R suffix to the device type (e.g., TLC27L9CDR).
Trimmed Offset Voltage:
TLC27L9...900 uV Max at 25°C,
VDD = 5 V
Input Offset Voltage Drift...Typically
0.1 uV/Month, Including the First 30 Days
Wide Range of Supply Voltages Over
Specified Temperature Range:
0°C to 70°C...3 V to 16 V
-40°C to 85°C...4 V to 16 V
-55°C to 125°C...4 V to 16 V
Single-Supply Operation
Common-Mode Input Voltage Range Extends Below the Negative Rail (C-Suffix, I-Suffix Types)
Ultra-Low Power...Typically 195 uW
at 25°C, VDD = 5 V
Output Voltage Range includes Negative Rail
High Input Impedance...1012 Typ
ESD-Protection Circuitry
Small-Outline Package Option Also Available in Tape and Reel
Designed-In Latch-Up Immunity
LinCMOS is a trademark of Texas Instruments Incorporated.


How do you follow a genuine drug breakthrough, a cure for hepatitis C? Andrew McConaghie visits Gilead's headquarters near San Francisco to hear how the company plans to sustain its huge success.
Gilead has enjoyed unprecedented, stratospheric success since the launch of its hepatitis C (HCV) drug Sovaldi in December 2013.
That's because Sovaldi and its follow-up Harvoni offer that rare thing, an outright cure. The drugs have transformed the outlook for people with HCV, with almost all of the 600,000 patients treated so far able to look forward to a life free of the disease.
Around half of those who have received the drug are in the US; ex-Baywatch star Pamela Anderson recently became the most high profile case, declaring herself cured (though not saying whether it was a Gilead or rival product) after living with the disease for more than a decade.
The numbers treated so far are just the tip of the iceberg – an estimated 185 million people worldwide are infected with the virus, which slowly and silently ravages the liver for years, symptoms often only emerging once the disease is advanced. If it remains undetected, the individual can develop fibrosis and cirrhosis, and may eventually need a liver transplant.
Previous drug regimens took months of treatment, with many patients failing to clear the virus completely, but Sovaldi and Harvoni have changed the outlook completely. Followed closely by rival direct-acting antivirals (DAAs) from AbbVie, Merck and Janssen, the drugs now offer a cure to more than 90 per cent of patients (depending on their genotype) within as little as eight weeks.
Although it will be decades away, the global elimination of HCV is now a realistic prospect.
The enormous success of its HCV drugs has equally transformed Gilead, making it one of the world's most valuable companies. The Sovaldi/Harvoni franchise is set to become the biggest-selling product in the world this year, with forecast 2015 sales of $18 billion.
HCV patients' gain has been payers' pain, however. The high cost of the drugs has created a huge problem for healthcare systems around the world, and the firm has been forced to offer substantial discounts on its prices, particularly in the US, where Sovaldi costs $84,000 for a course of treatment, or $1,000 per pill.
However even this pushback from payers has only tempered the firm's growth slightly. Revenues rocketed to $8.21 billion for the third quarter, up an exceptional 38 per cent compared to the same period last year.
This puts the company on track to earn more than $30 billion for the full year, pushing it up the industry rankings and likely to overtake 'big pharma' stalwarts GlaxoSmithKline (GSK) and AstraZeneca.
There are clear signs, however, that the explosive increase in Sovaldi and Harvoni sales is now slowing, with sales actually slipping back slightly between Q2 and Q3 this year. Inevitably, investors are hungry for more growth, and are asking what the firm can do to maintain its stellar performance.
Many investors would welcome Gilead spending its spare billions on buying another big pharma or biotech company – chief executive John Martin paid out $11 billion to snap up Sovaldi (sofosbuvir) and the company which discovered it, Pharmasset, in 2012.
Martin and his team have shown themselves adept at spotting golden opportunities in M&A and in-licensing, such as Sovaldi, over the years. But acquisitions alone can't be relied on to sustain a company, which means the in-house R&D team must develop its own breakthroughs.
The company's research chief is Norbert Bischofberger and he and his team are ambitious to keep pushing on to the next big challenge – and re-orientate their R&D focus when necessary.
Illustrating this point is a bold declaration from Bischofberger that Gilead has already ceased drug discovery in HCV and in HIV therapeutics – as there is nothing more to be done.
He explained that the company had looked at how to shorten treatment time for HCV even further – down to six weeks – but found that cure rate dipped below the 90 per cent threshold, and said anything less was now deemed not acceptable.
The firm's HCV research drug discovery team moved on to hepatitis B (hep B) a year-and-a-half ago, aiming to improve treatment, and ultimately find a cure.
Similarly, Gilead has stopped its HIV treatment discovery programme because there is little room for improvement, with these teams instead pursuing the holy grail – a cure for HIV.
Gilead feels it has the best-placed R&D team to achieve this feat. So is a cure is possible?
"I think we are far away, but I think it is possible," stated Bischofberger, adding that he had never thought a HCV cure would come so quickly.
HIV treatment has been the core of Gilead's 25-year success, and where it first employed a strategy of canny treatment combinations discovered in-house, and those discovered externally.
This approach helped it overtake then-market-leader GSK in around 2007, with drugs such as Viread, Truvada and Atripla (the latter a joint venture with Merck and Bristol-Myers Squibb [BMS]) now forming the backbone of HIV treatment around the world. These drugs have become market leaders, by taming the once-deadly HIV, turning the virus infection into a chronic disease, treatable with a single daily combination pill.
But an outright cure still evades Gilead and its rivals in the space, most notably ViiV (GSK's joint venture with Pfizer and Shinogi). One reason why current therapies can't cure HIV is that antiretrovirals cannot kill off the virus entirely – it evades elimination by hiding inside cells called CDF lymphocytes.
Bischofberger explained that the challenge is to eliminate these cells without causing an immune catastrophe.
Gilead's leading candidate for a cure, GS-9620, uses a tactic known as 'kick and kill', in which these latent cells are stimulated into an active mode. The theory is that the immune system can then recognise the infected cells and kill them.
After promising signs in animal studies, the drug is now in phase I trials, with initial results expected in the first half of 2016.
GS-9620 is also being investigated as part of a cure strategy for hep B, a virus that also evades detection by the immune system. Animal studies suggest the drug could provide a 'functional cure' for the disease, which, if translated into humans, would be an enormous breakthrough.
The company is also developing another compound, GS-4774, a therapeutic vaccine which stimulates a T-cell response to the hep B virus.
Hep B is an even bigger problem worldwide than hepatitis C – there are an estimated 350 million chronic patients globally, versus 150 million with HCV, according to the World Health Organisation.
In commercial terms, however, hep B is likely to be less lucrative: a greater proportion of hep B patients are in the developing world, where profit margins would be smaller for any company developing a cure.
On the other hand, the drugs could require a longer treatment time than Sovaldi and Harvoni, resulting in more sustained revenues.
While sofosbuvir didn't originate from Gilead, the firm's researchers did discover and develop ledipasvir, the NS5A inhibitor which combines with sofosbuvir to produce Harvoni.
The Harvoni combination has shown itself to be best in class, despite competition from Merck, AbbVie and Janssen. Now all that remains in HCV – at least in R&D terms – is to extend these cure rates and simplified regimens to patients with the most advanced disease or most hard-to-treat of the six different 'genotypes' of the disease.
Gilead recently re-confirmed its dominance in HCV treatment with data from a new fixed-dose combination of sofosbuvir and a next-generation NS5A inhibitor, velpatasvir (GS-5816). New trial results were presented at the annual meeting of the American Association for the Study of Liver Diseases, this year held in San Francisco, just a few miles from its headquarters in Foster City.
Across the six different genotypes in HCV, the relatively rare genotype 3 is now the most hard to treat and the most aggressive. But the new combination has shown high cure rates even in these patients.
By being 'pan-genotypic' the new combination would also do away with the need to test patients for their genotype. This would be a huge step forward in the developing world particularly.
These advances set Gilead up for a decade or more of continued growth in developed markets, with healthcare systems now under pressure to give the drugs to more diagnosed patients, and to uncover more undiagnosed sufferers.
At the same time, Gilead will face continued pressure on its prices, and will have to show further leadership in helping patients in emerging markets get fair access to the drugs.
Talking about the emerging science in Gilead's pipeline and in the wider scientific world, Bischofberger displays an irrepressible interest in all fields of medicine, not just his specialist areas, having written a paper on Alzheimer's diagnosis recently.
Sketching out different viruses like old friends (or rather old adversaries) on the whiteboard, Bischofberger jumps from one exciting scientific idea to the next with dizzying speed.
This buzz from new ideas is in the Californian air. Gilead's location in the San Francisco Bay area makes it part of perhaps the most ambitious and innovation-driven ecosystem in the world – Silicon Valley, home to innovators such as tech giants Google, Apple, Facebook and electric car pioneers Tesla, not to mention Genentech and Amgen and a host of biotech start-ups.
Asked about how new technologies might revolutionise drug discovery and healthcare, Bischofberger doesn't get starry-eyed about the potential – he makes it clear that 'the sky's the limit' thinking isn't helpful for drug researchers who, he says, work best when they have a single, well-defined problem to solve.
Nevertheless, he cites a number of emerging areas which have huge potential.
He casually mentions a recent meeting with Andrew Conrad, head of Google's Life Sciences division, saying they had discussed the potential of data derived from wearables, next-generation diagnostics and health monitors.
Bischofberger wouldn't say if Gilead is planning to work with Google, but clearly this is the 'disruptive' approach that rivals are investigating – Novartis and Sanofi are already working with the tech giant on miniature wearable monitors in diabetes.
Despite this enthusiasm for new approaches and tech links, Gilead's Foster City has few of the off-the-wall workplace novelties seen at tech firms, such as the bowling alley and beach volleyball at Google's headquarters in Mountain View. Collaborative working is in the air, however: drug development teams have rigged up an Xbox in one area of Gilead's continually-expanding facility, allowing teams to scrutinise and discuss 3-D models of new molecules, waving their hands to change the movement-activated screen.
Otherwise, there is no 'secret' to the company's success – researchers say Gilead has always worked in small-scale teams, with chemists and biologists working on a variety of projects, helping them to transfer insights and solutions from one project to another. Above all, researchers say dedication, good science and, just as importantly, good luck, are all needed to develop a medicine successfully.
He says other areas are also exciting. The microbiome – the native 'friendly bacteria' in the human gut – plays a huge role in regulating health, with numerous companies developing drugs which restore a healthy microbiome, and could thereby treat a wide range of conditions.
Most major pharma companies are engaged in oncology R&D, such are the scientific and commercial opportunities for new cancer treatments.
Gilead is no exception, but unlike in HIV and HCV, it is just a fledgling oncology business, certainly compared to the current leaders such as Roche, Novartis, Merck and BMS.
Chronic lymphocytic leukaemia (CLL) drug Zydelig is Gilead's lead cancer treatment, but this looks set to remain second best next to AbbVie/Janssen's rival treatment Imbruvica, which is easily outstripping it in revenues.
Commenting on the difference between cancer research and virology, Bischofberger says the field is far less predictable.
There is huge excitement in the field around new immunotherapy drugs, led by BMS's Opdivo and Merck's Keytruda, but Gilead doesn't have a direct stake in this field.
However one of the most eye-catching molecules in Gilead's pipeline is GS-5745, currently being investigating in a startling range of indications: gastric cancer and solid tumours, plus no fewer than four inflammation/respiratory settings – ulcerative colitis, Crohn's disease, COPD and rheumatoid arthritis.
The drug inhibits MMP9, an enzyme which plays a key role in the immune system. Bischofberger says there are no other companies with such a drug in their pipelines, adding that it could represent 'a substantial market'.
While oncology will be an important area, virology and the liver are clearly areas where Gilead will seek to maintain a lead.
The firm is developing GS-5374, a therapeutic treatment for Ebola – recently supplying the investigational drug on a compassionate use basis to treat the British nurse Pauline Cafferkey, whose Ebola infection had returned.
Cafferkey has now recovered from her second life-threatening episode. Bischofberger says Gilead knows it will never make money on the drug, but points out that it represents its commitment to global public health, particularly in the developing world.
A condition which is very much a disease of the developed world – and also potentially hugely lucrative – is Nonalcoholic Steatohepatitis (NASH).
A chronic liver disease characterised by inflammation and excessive fat accumulation in the liver, the condition can lead to progressive fibrosis, cirrhosis and liver failure, and is predicted to become the main reason for liver transplants by 2020.
NASH is estimated to affect 10 to 20 per cent of people in the developed world, and therefore represents a huge, untapped market for the company which can develop an effective treatment – analysts forecasting annual sales of $35-40 billion by the 2020s.
Gilead has two NASH candidates in phase II development, simtuzumab and GS-4997, but it is certainly keeping its eyes open for more promising candidates emerging from outside its own labs – the tactic which worked so well in HCV and HIV.
In January, Gilead in-licensed a new treatment from Phenex Pharmaceuticals, a private German biotech developing drugs called farnesoid X receptor agents.
Meanwhile, two biotech firms, Intercept and Genfit are seen as the firms most likely to reach the market first, but doubts about the efficacy of their candidates mean no-one, including Gilead, has yet swooped to acquire them.
Bischofberger concludes that there are "myriad external possibilities" and it seems certain that Gilead will make a move some time in the near future. The company will need to maintain its mix of good judgement and good luck to maintain its success.
However, asking it to repeat, or even surpass, the superlative story of Sovaldi and Harvoni may prove impossible, at least in commercial terms.
But, while investors might grumble at lower profits, developing a cure for HCV and HIV would put beyond question Gilead's reputation as one of pharma's most successful innovators.
Please note this article was updated on 30th November to include amended pipeline drug names – GS-5745 had been incorrectly listed as GS-5816 and GS-4997 was identified as GS-4887.


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يقدم 540 on Great South Motel خدمات لا غبار عليها وكل أشكال اللياقة وحسن الضيافة اللازمة لإسعاد ضيوفه. يمكن لضيوف الفندق الاستمتاع بالميزات التالية على أرض الفندق: تسجيل وصول/خروج سريع, تخزين الأمتعة, واي فاي في المناطق العامة, صف السيارات, التوصيل من وإلى المطار .
تعكس غرف الفندق البالغ عددها 38 المنتشرة في 1 طوابق جواً من الدفء والألفة.خدمات عصرية مثل تلفزيون بشاشة مسطحة, اتصال لاسلكي بالإنترنت, غرف لغير المدخنين, تدفئة, مكتب موجودة في بعض الغرف المختارة. كما أن مجموعة الخدمات الواسعة الموجودة في الفندق لضمان راحتك تترك لك الكثير من الخيارات لقضاء وقتك أثناء فترة إقامتك. مهما كانت أسبابك لزيارة أوكلاند، فإن 540 on Great South Motel هو الخيار الأفضل لإقامة مثيرة وممتعة.
على النزلاء الذين يستخدمون انتقالات المطار الخاصة بالموتيل، الاتصال بالموتيل مباشرة بعد الوصول في صالة الوصول العامة.
Needs aircon in rooms. Very hot and had to have fan on but was to noisy to sleep with.
It was not a good experience. Arrived 11.00pm to our Room after long trip and wanting to sleep. Room next to ours was party HQ for a group of travellers. We could hear every word said which was loud due to effects of alcohol. The swearing and crude jokes weren't appreciated either. The party lasted until after 1.00pm and they were up early banging the empty beer bottles as they cleaned up.
most expensive motel I have stayed in here or overseas and was very shabby threadbare carpet broken toilet seat shower ran warm water 10 seconds and then cold, shower head had to be held as would flop down and in, facing the wall, the room smelt strongly.
Room is fine but staff are not helpful AT ALL!
We had booked and paid for the room in advance through Agoda. When we arrived they did not have a record of us staying so it was lucky I had the Agoda confirmation. Though the male staff member was fantastic with helpful advice this was one of the few positives. The rooms furnishings were old and faded. The rubbish bin in the kitchen and bathroom was extremely small. The bathroom looked new but had lino on the floor which went part way up the wall with a plastic cheap shower placed in the corner. Heating and cooling was via a small portable heater and a floor fan. The kitchen and bathroom were dirty. The bedroom door did not shut fully. There was a pillow menu. Upon trying to arrange the selection with room service it appeared the female staff member was unhelpful and upon delivering the pillows was obviously not happy with being asked to do so. In fact upon trying to order we were asked how many pillows we already had as it seemed the pillow menu was for cosmetic value only. The room was noisy from traffic noises and people running up and down on the floor above. The room lacked any sound proofing. I have read many good reviews about this place and felt let down. The room was a three star at the best and for the price if you expected three star quality this may have been acceptable. The male staff member was the saving grace of this motel.


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The interpretation of george orwells animal farm in regards to the russian revolution
The Reich's war industries succeeded in raising tank production from in to in ; and the Wehrmacht doubled the number of its armored divisions to twenty-one though at the price of reducing the number of tanks per division by a third. At the heart of this new "left" are leaders that are co-opted voices, pseudo-intellectuals who destroy the words and empty of content of key concepts in a way that the alienation of the masses demonstrate at the language itself, thus preventing putting a real name to social process and things, and to identify the social phenomena.
By examining the attitudes of both the higher and the lower echelons of the army, this book will attempt to gage the degree to which the Wehrmacht constituted an integral part of state and society in the Third Reich.
Above the cops, the prosecutors, and the judiciary we have the true ruling class: Orwell shows Old Major in a sympathetic light - Old Major is seen as having good intentions but too much of a naive idealism to realise that not all animals share the same public-spiritedness that he has.
If we end up with a new Cold War -- and the risk is becoming a real one -- it won't be a small thing. After Jones and his wife are forced from the farm, the animals look forward to a society where all animals are equal and live without the threat of oppression.
Petro March 5, at 7: It is impossible to change wet clothing. It is the courage of the desperate [writes the chronicler of the GD], trying to defend what has already been won, the fear of falling alive into the hands of the enemy, and the instinct of self-preservation, which are the reasons for the willingness of the men fighting in the East to make this sacrifice.
Essentially Orwell wanted to save Socialism from Communism. Not only will you not be prosecuted or even lose your job, the inspectors will scrub your name from the report and, according to the article, the person in charge of the investigation will "slow roll" the eventual release of the report until you switch jobs.
National Socialist propaganda had long worked on the traditional repugnance and fear of the German toward the Russian.
And the fact is that they are not wrong in this perception: Here again the failure of technology resulted in tremendous misery. Orwell himself confessed in a letter written in "I have never met a genuine working man who accepted Marxism". It is like the relationship between schoolchildren, when a bully see a threat on the school yard and acts preemptively.
Although the Reich actually produced a growing number of war machines, the vast majority of German combat troops lived and fought in conditions of the utmost primitiveness. When considering the title for the novel Orwell mentioned in a letter that he was considering "The Last Man in Europe" - a clear indication that he saw Winston Smith as the last true free thinker in Europe.
Deny the little child that wants everything for himself. Was it a haven from the regime or an exceptionally effective school of National Socialism? Chapter 4 discusses the extent to which years of premilitary and army indoctrination distorted the soldiers' perception of reality.
Jones and Napoleon are as bad as each other - both exploit the animals for his own benefit: Today the whole neoliberal globalization system of capitalism is in danger by the depletion of the natural resources. This policy meant that not only were troops trained and grouped into units together, but also that the wounded could expect to rejoin their old comrades once they recovered.
Orwell saw his role as a writer to be the objective conscience of a society - he was trying to express the truth as he saw it.
Yet while the "primary groups" did more or less disappear, the army fought with far greater determination and against far greater odds than at any other time in the past.
Nor was this step sufficient to make up for the growing manpower gaps in the East. His two greatest anti-totalitarian novels—Animal Farm and —form the basis of his reputation. In fact, Russia is very un-exceptional in its pragmatic realization that to uphold these principles is not a matter of naive idealism, but a sound realistic policy goal.
In the world of there has been no improvement in the living standards of the average person since Here is a part of discussion from Kremlin Stooge that touch this theme in relation to Skolkovo techno-park.
As we shall see, this process had a major impact on the character, self-perception, and conduct of the Wehrmacht. Similarly, the Third Reich raised aircraft production from 12, in to 40, in There are certainly among our ranks those who fight for the idea of National Socialism, and others who fight for the Fatherland, that spot on the map for which risking one's life remains self-evident.
But perhaps the good news for the critics is precisely that Russia is not about to go away. As John Drury noted in his comment to U. This kind of "primary group," however, is in some respects the precise opposite of the one presented in the original theory, for it is very much the product not merely of social ties, but of ideological internalization, whereby humanity is divided into opposing groups of "us" and "them.
So the worries will live on, too, as will the sublimated wish to efface Russia. They have effectively infinite resources. Privatization of most govt.
Some countries, such as the United States, chose a more efficient manpower policy which treated soldiers as individuals to be sent wherever needed, rather than to a specific unit where they might have already formed, or were expected to develop personal ties.
Indeed, German soldiers had no trouble noting the importance of both. They act as a pack of dogs. Nor was the division's logistical situation much better, especially after the supply column of the Panzer regiment was wiped out in a Soviet tank raid.The Russian government simply does not understand that Washington regards Russian appeals to diplomacy, law, facts, evidence, as signs of extreme weakness and lack of confidence.
Washington and its puppet states do not need any facts. 8 days ago · The great Milton Friedman was a consultant for the Prime Minister of India. Friedman was looking out of a window in the PM office and noticed hundreds of men digging a trench with shovels and inquired why they didn't use backhoes.
It makes a very convincing case that the Saudi Government was involved in an act of war against the United States. Not simply terrorism — remember, the Pentagon, a military target, was one of the locations hit.
The other intended target for the plane that went down in PA was the Capitol. Download-Theses Mercredi 10 juin An m of the central sociology in Orwell's' Nineteen Eighty-Four',' Animal Farm' and' means to Catalonia'.
pub on George Orwell's homosexual gentleman. George Orwell a comfortable sister? A asceticism of John Newsinger' Orwell's Politics'. The response to the information from the FBI, he recalled, was "shock and horror." After a few weeks, the bureau asked him for information on his sources and their reliability and .
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Online payments also mean you can stress less. Have all the comforts of home in a great location when you live at Sterling Glen. Our community is just down the street from a variety of shopping and dining including Dempster's Sports Pub & Restaurant and Crossroads Plaza shopping center. Close to home you can enjoy the outdoors at Creek Island Park and along the banks of North Branch Rancocas Creek. Just a five minute drive away, downtown Mount Holly boasts a variety of local employers and is the home of the Burlington County Government offices. Pursue your education close to home at Rowan College's Mount Holly campus and take advantage of our proximity to Highway 206, Interstate 295, and the New Jersey Turnpike. Enjoy living less than 15 minutes from Joint Base McGuire-Dix-Lakehurst, making it easy for our enlisted residents to get to work.
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5 MINUTES WITH. DAVID MACK!
FROM THE MAN HIMSELF: David Mack is the creator, author and artist of KABUKI, now published through the ICON imprint..
Mack's work has garnered nominations for two 1999 International Eagle Awards in the categories of Favorite Comic Artist (Painted), and Best Cover Art of the Year (Painted), the Eisner Awards in the category of Best Painter, and both the Harvey and Kirby awards in the category of Best New Talent, as well as other awards and nominations. KABUKI, has earned David international acclaim for its innovative storytelling, painting techniques, and page design. It is available in seven different languages in addition to well over a million copies of KABUKI Comics, Paperbacks, and Hardcovers in print in the U.S. alone. Mack has toured and exhibited throughout, Europe, Asia, and America. He was the first American to be nominated for Germany's most prestigious Max-Und-Moritz award in the category of best imported comic.
David did not attend a specialized art school, but earned a full scholarship to a University for five years. There, he studied multiple disciplines in art and academics, including World History, Anatomy & Physiology and the Japanese Language. He graduated with a BFA in Graphic Design and a Minor in English. His books have been the subject of under-graduate and graduate university coursed in Art and Literature, and listed as required reading. His work has been studied in graduate seminars at USC and hung in the Los Angeles Museum of Art.
In addition to the writing and cover art for Daredevil, and writing and painting the KABUKI Comic Books, David has also written the treatment for the KABUKI Film which is in pre-production with Fox Animation, a division of Twentieth Century Fox. Along with writing duties, his film credits will include Visual Designer, Creative Consultant, and Co-Producer.
Mack has illustrated and designed jazz and rock albums including work for Paul McCartney) for both American and Japanese labels, and worked as a designer for companies in Hong Kong.
KABUKI #1 LIMITED EDITION ALEX MALEEV COVER - SIGNED BY DAVID MACK
DF: How has the transition been from Image to ICON?
DAVID MACK: It has exceeded all of our expectations. Everyone involved in the transition have been great to work with. And Bendis, Oeming and I are very grateful to our readers. Both the new ones and those that have been with us from the beginning.
DF: What is the schedule of Kabuki moving forward?
DAVID MACK: I'll continue to do publish Kabuki at Marvel ICON bi-monthly like I always have before. All six volumes of Kabuki continue to be available from Image in paperback and hardcover.
DF: Will you be doing any more work on Daredevil? Any other Marvel projects in the works?
DAVID MACK: I don't have any immediate plans to return to Daredevil. I will continue to do some writing for some other Marvel projects in the future.
DF: What does the immediate future hold for Kabuki? Long term?
DAVID MACK: The current Kabuki storyline, "The Alchemy" will be a fairly long story. At least 8 issues, maybe longer. I have the next several Kabuki storylines already written. And I will also be doing storylines of each of the other Noh Agents. Tigerlily or Siamese will probably be the next to have their stories told.
DF: Who are your biggest artistic influences? Who influences your writing?
DAVID MACK: My mother has been my biggest creative influence. She was a first grade school teacher so she always had art supplies for me to use, and she was always creating artistic ways to teach her students. A lot of the things I learned as a child from my mother are creative principles that I use everyday in my writing and artwork.
DF: What's your dream assignment at DC? Marvel?
DAVID MACK: I'd like to eventually do a Batman story at DC. I'd enjoy working on a Sandman story with Neil Gaiman. I will definitely do another Marvel project with Brian Michael Bendis. I'd like to make a Marvel hardcover collection of all the Daredevil and Alias covers that I've made.
Our selection of comics by David Mack can be found here and we highly recommend checking out his work on Kabuki.
We'll be back next week with another installment of 5 Minutes With. !


If you're in the position to minister to children, I'd love to give you something.
This 5 day free VBS curriculum teaches children from all backgrounds the story of creation, sin, and redemption, bringing the good news of the Cross into focus in a simple allegory that they can all understand.
I believe there is a gap in learning in so many of our children, primarily because our nation has moved to being largely un-churched. Where in years past, most everyone had spent their Sundays learning the story of the bible and our good God, and understood sin and Christ's work through years of teaching, many young people today don't have that learning or knowledge. They don't have the background narrative. They hear the words "cross," and "Christ," and "salvation," and "sin," but they don't have a reference. It doesn't make sense.
They don't understand where we come from- they don't understand the sovereignty of God, they don't understand the gravity of their sin and so the wonderful work of salvation that Christ did is not recognized as the amazing gift that it is.
That's where this story comes in.
In five days, with joyful, welcoming, and yet solemn words, the story of the Gospel -from the beginning- is laid out clearly for children and all listeners.
Drawing on the five colors of the wordless book, the allegory of the King and the Kingdom illustrates simply Creation, The Fall, the Ministry of Christ, the Crucifiction, the Message of Salvation, and the call to grow in Christ.
With games, crafts, decorations, and even snacks to cement the message, and the Word of God proclaimed through memory verses and songs, I pray that this curriculum will be a catalyst for revival in your church.
The free vacation bible school curriculum is organized in sections. Feel free to use the drama alone for ministry.
I am especially honored to release it for small groups, as I've seen first hand the struggle it is to lead groups on a tight budget. But if your group is in the position to donate in return for my labor, I would be very grateful.
I hope that this is a useful resource for you and that it blesses the children that you minister to with your program. I'd love messages or photos of your group using it!
If you know of any groups who might like this curriculum, please pin the image below or share the link. God bless you!


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Campaigners Seek Arrest of Former CIA Legal Chief over Pakistan Drone Attacks
July 16th, 2011 - by admin
Peter Beaumont / The Guardian – 2011-07-16 00:45:32
http://www.guardian.co.uk/world/2011/jul/15/cia-usa
LONDON (July 15, 2011) — Campaigners against US drone strikes in Pakistan are calling for the CIA's former legal chief to be arrested and charged with murder for approving attacks that killed hundreds of people.
Amid growing concern around the world over the use of drones, lawyers and relatives of some of those killed are seeking an international arrest warrant for John Rizzo, until recently acting general counsel for the American intelligence agency.
Opponents of drones say the unmanned aircraft are responsible for the deaths of up to 2,500 Pakistanis in 260 attacks since 2004. US officials say the vast majority of those killed are "militants". Earlier this week 48 people were killed in two strikes on tribal regions of Pakistan. The American definition of "militant" has been disputed by relatives and campaigners.
The attempt to seek an international arrest warrant for Rizzo is being led by the British human rights lawyer Clive Stafford Smith of the campaign group Reprieve, and lawyers in Pakistan. The lawyers are also building cases against other individuals, including drone operators interviewed or photographed during organised press facilities.
A first information report, the first step in seeking a prosecution of Rizzo in Pakistan, will be formally lodged early next week at a police station in the capital, Islamabad, on behalf of relatives of two people killed in drone strikes in 2009. The report will also allege Rizzo should be charged with conspiracy to murder a large number of Pakistani citizens.
Now retired, Rizzo, 63, is being pursued after admitting in an interview with the magazine Newsweek that since 2004 he had approved one drone attack order a month on targets in Pakistan, even though the US is not at war with the country.
Rizzo, who was by his own admission "up to my eyeballs" in approving CIA use of "enhanced interrogation techniques", said in the interview that the CIA operated "a hit list". He also asked: "How many law professors have signed off on a death warrant?"
Rizzo has also admitted being present while civilian operators conducted drone strikes from their terminals at the CIA headquarters in Virginia.
Although US government lawyers have tried to argue that drone strikes are conducted on a "solid legal basis", some believe the civilians who operate the drones could be classified as "unlawful combatants".
US drone strikes were first launched on Pakistan by George Bush and have been accelerated by Barack Obama.
Much of the intelligence for the attacks is supplied either by the Pakistani military or the ISI, the country's controversial intelligence agency.
Both have blocked journalists and human rights investigators from visiting the tribal areas targeted, preventing independent verification of the numbers killed and their status.
While Stafford Smith of Reprieve estimates around 2,500 civilian deaths, others say the number is closer to 1,000. US sources deny large numbers of civilian deaths and say only a few dozen "non-combatants" have been killed.
While killing civilians in military operations is not illegal under international law unless it is proved to be deliberate, disproportionate or reckless, Stafford Smith believes the nature of the US drone campaign puts it on a different legal footing.
"The US has to follow the laws of war," he said. "The issue here is that this is not a war. There is zero chance, given the current political situation in Pakistan, that we will not get a warrant for Rizzo. The question is what happens next. We can try for extradition and the US will refuse.
"Interpol, I believe, will have to issue a warrant because there is no question that it is a legitimate complaint."
The warrant will be sought on the basis of two test cases. The first centres on an incident on 7 September 2009 when a drone strike hit a compound during Ramadan, brought by a man named Sadaullah who lost both his legs and three relatives in the attack.
The second complaint was brought by Kareem Khan over a strike on 31 December 2009 in the village of Machi Khel in North Waziristan which killed his son and brother.
Both men allege Rizzo was involved in authorising the attack. The CIA refused to comment on the allegations.
The pursuit of Rizzo will further damage US-Pakistani relations, which are already under severe strain following years of drone attacks and the killing of Osama bin Laden in May. Last week the US suspended $800m (£495m) in military aid to Pakistan.
The US launch its first drone strike against a target in Pakistan in 2004, the only one for that year. Last year there were 118 attacks after Obama expanded their use in 2009, while 2011 has so far seen 42.
The use of drones has been sharply criticised both by Pakistani officials as well as international investigators including the UN's special rapporteur Philip Alston who demanded in late 2009 that the US demonstrate that it was not simply running a programme with no accountability that is killing innocent people.


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Jennifer Lopez Reveals Who's Going to Walk Her Down the Aisle During Wedding to Alex Rodriguez
16th Sep 2019 | Source: msn.com
Jennifer Lopez's kids will be a big part of her wedding to Alex Rodriguez.
ET's Nischelle Turner was exclusively with the multi-hyphenate in Miami on Thursday, as she surprised fans at a screening of her new film,Hustlers. While speaking about her upcoming nuptials with Rodriguez, Lopez revealed that her 11-year-old son, Max, will walk her down the aisle.
"Of course," gushed the actress, who shares Max and his twin sister, Emme, with her ex, Marc Anthony.
Who's walking her down the aisle is one of the only things Lopez has nailed down about the upcoming event. As she told ET, she can't even confirm Rodriguez's recent comments that it'll be a "long flight" away.
"He's just saying things," she shared. "We're talking about it, but we don't have any firm plans... and we're talking about a lot of places [to get married in], but I don't know yet."
The actress hasn't even picked a time to tie the knot. "We can't narrow it down yet," she revealed.
For now, Lopez is basking in the success of Hustlers -- which has already been earning rave reviews and awards buzz.
"There's a lot of buzz, which is exciting and all the girls have been working hard promoting it and getting it out there. People seem to be really interested, so that's fun," she said.
"It feels amazing [to get personal recognition too]," Lopez added. "You know, I'm looking at some of these reviews and thinking like, 'OK!' and feeling like I already won. It's amazing. I'm not really thinking about anything else except kind of living in the moment and feeling really happy that people are loving it."
The "On the Floor" singer was especially excited to surprise Miami audiences at the screening.
"I've always loved [this city]," she said. "I did my second movie here many, many, many years ago and even then I knew. I was like, 'I'm going to live here.' I just had a kinship with it. It was just a connection that I had with this city from the first time I did the movie called Blood and Wine here with Jack Nicholson many years ago. Right then I knew. And it's so funny now, me and my kids live here."
The Rock's father dies at 75
Kylie Jenner surprises fan with USD200K
Tracee Ross teases 'Girfriends' reunion


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Shaktimaan: Minnal Murali's Basil Joseph to direct the desi superhero movie? Find out
Ever since Sony Pictures announced a live-action movie of India's most famous superhero, Shaktimaan, the fans have been going crazy over it. While the project is still in the planning stage and the makers are working on ensembling a worthy...
Not Black Adam, Dwayne Johnson was to make DCEU debut in Suicide Squad, Find out more
After years of hard work, anticipation and manifestation, Dwayne Johnson starrer Black Adam finally released with its yearning to change the hierarchy of power in the DCEU. With the movie getting mostly positive responses from the early screenings and first-day...
Teaser of Shah Rukh Khan starrer Pathan to unveil on his birthday; Read more
The King of Bollywood, Shah Rukh Khan, has been away from the silver screen for years and he is all geared up to break his self-imposed sabbatical with the keenly-anticipated action-thriller Pathan. While the first-look images and sneak-peeks into...
Jr. NTR and Ram Charan to attend premieres in Tokyo as RRR gears up for release in Japan
Filmmaker SS Rajamouli's recent release RRR featuring Jr. NTR and Ram Charan lived up to the expectations of its hype and the makers are currently running campaigns for Oscars 2023. RRR has been submitted in 15 categories for consideration and...
It's a schedule wrap for Sam Bahadur, Vicky Kaushal shares pictures with the team
Last year, filmmaker Meghna Gulzar and URI actor Vicky Kaushal announced a collaboration for a biopic based on the life and times of Field Marshal Sam Manekshaw, one of India's greatest war heroes. The team began filming the keenly-anticipated...
Shah Rukh Khan and John Abraham starrer Pathaan to get a sequel? Here's what we know
Indian actor Shah Rukh Khan has been on a self-imposed sabbatical for years and he is finally ready to greet his fans with the keenly anticipated spy thriller Pathaan. Helmed by Siddharth Anand, the movie adds to YRF's spy universe...
Mani Ratnam on reuniting with Shah Rukh Khan for a movie: I'll go and ask him
One of India's most acclaimed filmmakers, Mani Ratnam, and Shah Rukh Khan had joined hands for the romantic thriller movie, Dil Se, which completed 24 years last month. While the movie failed to gain the recognition that it deserved,...
Scoop: Shah Rukh Khan's Jawan earns 250 crore rupees before its theatrical release; Read more
Shah Rukh Khan is undoubtedly one of the greatest actors the Indian film industry has ever produced and the megastar enjoys a gigantic fan following across the globe. However, after the box office failure of his last release Zero, SRK...
Ajay Devgn and Sidharth Malhotra starrer Thank God gets banned in Kuwait
The Hindi-language fantasy comedy, Thank God, has been the talk of the town lately after the release of its trailer. The first look at the Indra Kumar directorial received a mixed response from the audience for its satire comedy and...
Sidharth Malhotra to film new schedule of action thriller Yodha in Manali
Following the spectacular performance in the biographical war film Shershaah, Indian actor Sidharth Malhotra is all prepped for another soldier character as he reunited with filmmaker Karan Johar for Yodha. Sidharth will begin filming a new schedule for the action thriller...
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The Mass Spectrometry Platform aims to ensure that Novo Nordisk Foundation Center for Protein Research (CPR) retains world-leading mass spectrometry technology in-house, to provide technical support and maintenance for the Proteomics Program, and to provide analytical proteomics support for CPR research groups.
Advanced mass spectrometry-based proteomics is a key technology to Novo Nordisk Foundation Center for Protein Research (CPR) at the University of Copenhagen.
To ensure that the proteomics technologies maintained at the highest international levels, and made available for internal research groups, we have established a proteomics support platform.
The platform has access to the latest generation Orbitrap mass analyzers, the Q Exactive HF-x and Orbitrap Fusion Lumos mass spectrometers which provide unprecedented accuracy, speed and sensitivity.
Mass Spectrometry offers workshops on liquid chromatography and mass spectrometry's latest technological developments and maintenance to researchers of the department. It also participates in teaching master and PhD students as well as summer school participants.


Magenta is committed to supporting a fair and ethical workplace for all of our colleagues.
Currently Magenta is 100% female, but diversity is important to us. We will always employ the most suitable person for each job role, irrespective of gender and monitor diversity on applications, however, we are passionate about encouraging more women into our profession, which is generally still predominately male.
The history of Magenta and its owner managers demonstrates its strong roots supporting gender equality and the progression of females in the financial planning profession.
Magenta was formed by directors Julie Lord and Gretchen Betts in 2016. Between them they have over 40 years financial planning experience.
Julie ran her own business for 17 years, championing the development of women in the business and some of those employees now work at Magenta. She hired Gretchen in 2012 while working for a larger wealth management company and they have worked closely together ever since, with Gretchen taking on the role of MD at Magenta when they established the business together.
At Magenta we believe that the skill and empathy women can bring to our profession is largely undervalued, both in the number of women who are encouraged to enter the profession and by inequality of pay. We want to ensure that we are part of any movement that is working towards changing this.
Our target is to maintain representation of women in senior management roles in Magenta of at least 50% at all times. We have put clear measures in place to help us maintain this.
Establishing (and publishing) our business values, both at Firm and Team level, in a language that reflects our corporate style and includes empowerment, respect, kindness and communication.


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Tag: Paralympics
Author claimes1Posted on August 11, 2017 December 12, 2018 Categories Disability Horizons, InterviewsTags Author, Campaigner, Charity, Disability, Disability Horizons, Diversity, fundraising, interview, Matt Hampson, Parallel London, Paralympics, Rugby, SCI, Spinal Cord Injury, Sport, Tetraplegic, Wheelchair life1 Comment on Interview | Matt "Hambo" Hampson
Interview | Samantha Renke
Actress, TV Presenter & Disability Campaigner
Here I interview actress, presenter and disability campaigner Samantha Renke. She reveals all about growing up with a disability and her dreams of becoming an actress despite brittle bone disease. She also discusses her involvement with Parallel London 2017.
Here is the link to the interview, originally posted by Disability Horizons.
Parallel London
The 3rd September sees the return of Parallel London, a mass-participation race for people of all abilities. Feature writer Carrie Aimes speaks to disabled actress Sam Renke, ambassador for Parallel London, about why the event is so important and why you should get involved.
Despite her disability, 31 year-old Samantha Renke moved to London five years ago to pursue her long-held dream of becoming an actress. Now a familiar face to many, she has since starred in an award-winning film, music videos, webisodes as well as the popular Maltesers television advert. The former teacher is also a columnist, disability campaigner and charity worker.
As if all this is not enough to keep her busy, Samantha was recently appointed ambassador for Parallel London. Here, we learn more about the rising star and her involvement with Parallel London, the world's first fully-inclusive, fully accessible mass-participation event.
1. Would you please tell us a little about yourself, your disability and how it affects you?
I was born in Germany to a German mother and British father. We moved to the UK when I was a baby. I studied French, German, Sociology and European Studies at the University of Lancaster before completing my PGCE in Secondary Education at the University of Cumbria.
Following this, I worked as a high school teacher for a number of years. I was also a trustee for the Brittle Bone Society for 6 years, supporting people with my condition, Osteogenesis Imperfecta (brittle bones).
I am a full time wheelchair user and my bones break very easily. I've had around 200 fractures starting in my mother's womb! I get fatigue and have some breathing difficulties. I do have a PA to help me with day-to-day tasks, which is my saving grace and allows me to live my life to the fullest.
After moving to London in 2012, my debut role was playing Alice Gardiner, a mischievous disabled girl who absconds to London in the film Little Devil. I won best actress and the film won Best Film in the Diversity of Arts category at the LA Diversity Film Festival. From there, I got an agent at Visable People and have appeared in a number of projects since.
I still love my charity work and I am patron of Head2Head, a multi-sensory theatre group. I am also affiliated with some other well-known charities, such as SCOPE. I love writing and have a regular column in Posability magazine and write regular blogs for the Huffington Post.
Maltesers TV Advert
2. People may know you best from the popular Maltesers TV adverts, which aired during the Paralympics. Why did you want to be part of that, and what response did you receive?
I think it's any actor's dream to be part of a national commercial as it's certainly great exposure. More than that, I knew the concept was revolutionary and I felt so excited about the positive impact the advert would have.
Apart from some online trolling, the response has been phenomenal. Every day, without fail, when I leave my flat in East London I am recognised. People want my autograph and selfies. The lovely thing is that my disability is not the reason people stare at me now.
3. You're a celebrity who happens to have a disability. What does this mean to you, and what challenges have you faced?
I always loved drama at school and attended a number of after-school drama clubs. However, one of my teachers took me to one side and told me not to get my hopes up of being cast in an acting role. I suppose at that time, 15 years ago, she had a point – the representation of disability within the media was non-existent. Nevertheless, this was heart-breaking to hear and I dropped all of my classes.
But after being a teacher for a couple of years, I knew I wanted to pursue my passion again. I hope my story encourages more people who have disabilities to get involved in TV, film and presenting. I'd like to think that when I have my own family, my children will follow their dreams, no matter what anyone else says.
4. You were recently made an Ambassador for Parallel London. How did you come to be involved with this event?
My amazing friend Daniel White and his daughter Emily, who run the awesome blog the Department of Ability, introduced me to the Parallel team and the rest is history. It is a total love affair!
5. Can you tell us more about what Parallel London is and what it means for disabled people?
Parallel London is a fully-inclusive and accessible fun run and free family festival held at the iconic Queen Elizabeth Olympic Park. Open to all ages and abilities, there are no cut-off times and no barriers to involvement.
Parallel's inaugural event took place on 4 September 2016. We hosted over 3,000 participants, of which, 41% declared themselves as having a disability. 5,500 people attended our family festival showcasing all different types of inclusive and accessible attractions. This year it is being held on the 3rd September.
6. Why is it so important to you to be involved with such an event?
Being part of a team and having people around you who love and support you for you is so important. As a child I did not get involved in anything as much as I would have liked, and this left me feeling isolated a lot. Parallel is all-inclusive, no matter what your ability. I think this is just amazing.
7. Is there any insider information you, as ambassador, can exclusively reveal to Disability Horizons readers?
Expect some surprises! I'm going to be getting my burlesque on with the amazing Folly Mixtures and their all-inclusive Burlexercise master class. So get your feather bowers ready.
My good friend Stephen Dixon from Sky News will also be at the event presenting for Sky and hosting with yours truly. He has told me that, regardless of the weather, he will be wearing his short shorts!
8. How can we all get involved with Parallel London?
Parallel London is taking place at Queen Elizabeth Olympic Park on the 3rd September. There's a 10km, 5km, 1km, 100m and the Super Sensory 1km walk, cycle, push or run – whatever you want to do. It's for all ages and abilities and everybody can be running side-by-side. You can get sponsorship for any charity or cause that matters to you – so why not give it a go?!
For more information on Parallel London visit www.parallellondon.com. You can also find out all the latest information about the event by following Parallel London on Twitter.
Author claimes1Posted on July 21, 2017 December 12, 2018 Categories Disability Horizons, InterviewsTags Brittle Bones, Campaigner, Celebrity, Charity, Disability, Disability Horizons, Diversity, Girl Power, interview, Parallel London, Paralympics, Samantha Renke, Sport, Wheelchair life, WomenLeave a comment on Interview | Samantha Renke


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package org.camunda.bpm.engine.impl.form;

import java.io.Serializable;
import java.util.ArrayList;
import java.util.List;

import org.camunda.bpm.engine.form.FormData;
import org.camunda.bpm.engine.form.FormField;
import org.camunda.bpm.engine.form.FormProperty;

/**
 * @author Tom Baeyens
 * @author Daniel Meyer
 */
public abstract class FormDataImpl implements FormData, Serializable {

  private static final long serialVersionUID = 1L;

  protected String formKey;
  protected String deploymentId;
  protected List<FormProperty> formProperties = new ArrayList<FormProperty>();

  protected List<FormField> formFields = new ArrayList<FormField>();

  // getters and setters //////////////////////////////////////////////////////

  public String getFormKey() {
    return formKey;
  }
  public String getDeploymentId() {
    return deploymentId;
  }
  public List<FormProperty> getFormProperties() {
    return formProperties;
  }

  public void setFormKey(String formKey) {
    this.formKey = formKey;
  }

  public void setDeploymentId(String deploymentId) {
    this.deploymentId = deploymentId;
  }

  public void setFormProperties(List<FormProperty> formProperties) {
    this.formProperties = formProperties;
  }

  public List<FormField> getFormFields() {
    return formFields;
  }
  public void setFormFields(List<FormField> formFields) {
    this.formFields = formFields;
  }
}

redpajama_set_name: RedPajamaGithub


text:
package com.itfvck.wechatframework.api.pay.protocol.report;

/**
 * 测速上报请求对象
 *
参考开发文档

 *

 * Created by xuwen on 2015-12-13.
 */
public class ReportRequest {

    private String appid ;
    private String mch_id ;
    private String device_info;
    private String nonce_str;
    private String sign;
    private String interface_url;
    private int execute_time_;
    private String return_code;
    private String return_msg;
    private String result_code;
    private String err_code;
    private String err_code_des;
    private String out_trade_no;
    private String user_ip;
    private String time;

    public String getAppid() {
        return appid;
    }

    public void setAppid(String appid) {
        this.appid = appid;
    }

    public String getMch_id() {
        return mch_id;
    }

    public void setMch_id(String mch_id) {
        this.mch_id = mch_id;
    }

    public String getDevice_info() {
        return device_info;
    }

    public void setDevice_info(String device_info) {
        this.device_info = device_info;
    }

    public String getNonce_str() {
        return nonce_str;
    }

    public void setNonce_str(String nonce_str) {
        this.nonce_str = nonce_str;
    }

    public String getSign() {
        return sign;
    }

    public void setSign(String sign) {
        this.sign = sign;
    }

    public String getInterface_url() {
        return interface_url;
    }

    public void setInterface_url(String interface_url) {
        this.interface_url = interface_url;
    }

    public int getExecute_time_() {
        return execute_time_;
    }

    public void setExecute_time_(int execute_time_) {
        this.execute_time_ = execute_time_;
    }

    public String getReturn_code() {
        return return_code;
    }

    public void setReturn_code(String return_code) {
        this.return_code = return_code;
    }

    public String getReturn_msg() {
        return return_msg;
    }

    public void setReturn_msg(String return_msg) {
        this.return_msg = return_msg;
    }

    public String getResult_code() {
        return result_code;
    }

    public void setResult_code(String result_code) {
        this.result_code = result_code;
    }

    public String getErr_code() {
        return err_code;
    }

    public void setErr_code(String err_code) {
        this.err_code = err_code;
    }

    public String getErr_code_des() {
        return err_code_des;
    }

    public void setErr_code_des(String err_code_des) {
        this.err_code_des = err_code_des;
    }

    public String getOut_trade_no() {
        return out_trade_no;
    }

    public void setOut_trade_no(String out_trade_no) {
        this.out_trade_no = out_trade_no;
    }

    public String getUser_ip() {
        return user_ip;
    }

    public void setUser_ip(String user_ip) {
        this.user_ip = user_ip;
    }

    public String getTime() {
        return time;
    }

    public void setTime(String time) {
        this.time = time;
    }

    @Override
    public String toString() {
        return "ReportRequest{" +
                "appid='" + appid + '\'' +
                ", mch_id='" + mch_id + '\'' +
                ", device_info='" + device_info + '\'' +
                ", nonce_str='" + nonce_str + '\'' +
                ", sign='" + sign + '\'' +
                ", interface_url='" + interface_url + '\'' +
                ", execute_time_='" + execute_time_ + '\'' +
                ", return_code='" + return_code + '\'' +
                ", return_msg='" + return_msg + '\'' +
                ", result_code='" + result_code + '\'' +
                ", err_code='" + err_code + '\'' +
                ", err_code_des='" + err_code_des + '\'' +
                ", out_trade_no='" + out_trade_no + '\'' +
                ", user_ip='" + user_ip + '\'' +
                ", time='" + time + '\'' +
                '}';
    }
}


text:
"I have listened to Sofronitsky, Gilels, Richter and Ashkenazy – great Scriabin players all. Young Matthieu Idmtal has the potential to join that lofty group." – The American Record Guide
"He plays with high sensitivity, with flair and imagination, and most of all, with a lot of poetry." – Radio Klara
"Belgian pianist Matthieu Idmtal creates a wonderfully colorful and profound universe that not only surprised me, but even more completely captivated me. His great technical vocabulary leads to an interpretation that combines a refined sound with penetrating expressiveness in a sublime way." – Opus Klassiek
It is clear that Matthieu Idmtal has become an established name on national and international stages.
Press and public have witnessed his distinctive musical personality, and have praised his highly sensitive interpretations.
As a prize winner of more than 15 international competitions, Matthieu Idmtal has been a guest at the main Belgian stages such as Bozar, Flagey, Handelsbeurs, De Bijloke, De Singel, Concertgebouw Brugge, Philharmonie de Liège,… and made part of international festivals such as the Klara Festival, Festival Musiq'3, Les Sommets du Classique (Switzerland), Musicales and Côte Chalonnaise (France), Les Sommets Musicaux de Gstaad (Switzerland), Festival Musical d'Arcangues (France), Les Festivals de Wallonie, Midis-Minimes, Brussels Piano Festival, Podium Jonge Musici,…
In recent years, Matthieu Idmtal has established himself as a leading interpreter of the music of Alexander Scriabin, and gave several recitals entirely dedicated to the Russian composer.
He often performed for the European Scriabin Society, and was praised for his emotional intensity and deeply poetic and personal interpretations.
In September 2018 his first solo-CD appeared containing two major piano cycles of Alexander Scriabin, and very quickly received high critical acclaim such as: 'This is definitely one of the better Scriabin CD's of the last ten years' (De Muze) or,
'In a sublime way, he joins the beauty of sound with expression. His playing contains a variated and colourful toucher, supple phrasing, a natural rubato, pricesly elaborated dynamics, and a contagious imagination. Idmtal is a poet at the piano.' (Magazine Stretto).
The CD received five star reviews by national radio station Radio Klara, and prestigious music magazines such as Classica.
Last seasons, Idmtal gave solo recitals and concerts with orchestra in Belgium, Italy, the Netherlands, France, Germany, Great Britain, Switzerland, Latvia and Spain.
In addition to his solo concerts, he is a sought-after partner to play chamber music and won multiple awards in pianduo and piano/violin formations.
Such awards include top prizes at competitions as the 'Youth 'n Classic Prize' (Belgium), 'Concorso Internationale San Cristoforo' (Italy), or the press- and publicprize at the International 'Chamber Music Competition Almere' (Netherlands).
In 2017, Matthieu Idmtal became 'Supernova', a prize given by the Belgian music critics, programmors, and classical music radio stations. The award would offer a concert tour through the whole country with his violin partner, Maya Levy.
In the end of 2016, they recorded their first CD containing the complete violin sonatas of E. Grieg, which received unanimous positive reactions in the press.
The repertoire of Matthieu Idmtal ranges from the baroque period till music of nowadays, but he has always had a particular attention to (Post-) Romantic music, with Frédéric Chopin and Alexander Scriabin as main composers.
His affinity with the former made him create the 'Brussels Chopin Days': an international concert series dedicated to F. Chopin, of which Matthieu Idmtal is the artistic director since 2013.
He also makes a point of bringing lesser known works into the spotlights, and has interest in jazz music.
His experience makes him a regular guest to give masterclasses, as well as being jurymember in national and international music competitions.
Matthieu Idmtal feels an endless gratitude to his teachers Frima Nakimovitch, Maria Andreeva, and Vitaly Samoshko, and is thankful for every inspiring and marking musical encouter that influenced him to be the musician he is today.


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text:
Ocean City's Gillian's Wonderland Pier Faces Auction, $8M in Debt
Gillian's Wonderland Pier
One of the cornerstones of the Ocean City Boardwalk, Gillian's Wonderland Pier is facing a possible bank auction after defaulting on $8 million in mortgage debt, according to a report by NBC10 Philadelphia.
Gillian's, the 91-year-old, third generation family amusement pier at 6th Street on the Ocean City Boardwalk is owned by Ocean City Mayor Jay Gillian and his wife, Michelle.
According to Ted Greenberg's report on NBC10, court records in state Superior Court's Office of Foreclosure show that the Gillians owe First Priority Bank about $8 million in mortgage debt On Wonderland Pier.
Judge Michael J. Blee ordered Jan. 21 that the property be put up for auction in order to satisfy the debt.
In a statement, Gillian told NBC10 that he had found new financing and that the venerable amusement pier would not be going up for auction and would be open as usual for summer 2021.
"I want to reassure our loyal guests that Wonderland Pier will be open for business, as usual, for the 2021 season. Like many business across the nation, Gillian's Wonderland Pier was deeply affected by the COVID-19 shutdown and restrictions. But we have secured financing, and we look forward to another WONDERful summer in America's Greatest Family Resort."
NBC10 points out that bank records show the financial troubles date back to 2019, prior to the pandemic business slowdown. Gillian told NBC10 that 2019 was a "soft year" for the amusement pier.
Sunday night, Mayor Gillian posted this Facebook message announcing that Gillian's Wonderland Pier would be open for business in the summer of 2021.
KEEP READING: Get answers to 51 of the most frequently asked weather questions...
Filed Under: Gillian's Wonderland Pier, Ocean City, Ocean City Mayor Jay Gillian
Categories: AC, Community, Lifestyle, Lite Rock Morning Show, New Jersey News, News, South Jersey News


Who is Alex Rodriguez dating Now Alex Rodríguez EX Girlfriends List Wife? The answer of this major question as well as brief history of her past relationships love is briefly describes. From a period of time Alex dating with latest girlfriend Trroie Wilson. She is beautiful hottest celebrity and both are very happy in their life. On the other hands he also becomes good relation with their ex wife is known to be Cynthia Scurtis and both met to each other in 2001 at a gym in Miami and Cynthia is so beautiful and hottest girl and she having graduate degree in psychology. Alex falling in love with his ex wife and decided to getting married in 2002 and Cynthia becomes baby mama of Alex daughter and both don't becomes having long time relation in their life and Cynthia getting divorce in April, 2008. Alex wants to become their new girlfriend Torrie Wilson of the year 2011. Wilson is also model, actress, fitness competitor and also retired professional wrestler and former WWE Dive. She is well known due to WWE (World Wrestling Entertainment) and becomes world champion wrestling and also well performs in Raw and Smack Down. Alex stated their baseball career from their high school and becomes first time entry drafted in first overall selection in MLB draft of the year 1993 and after that he becomes first debut in the major leagues in 1996.
Who is Alex Rodríguez Dating Now Alex Rodríguez EX Girlfriends List Wife Detail Picture are given in gallery.
Alex and his girlfriend Wilson becomes lovely and physically fit couple and mostly spends time to each other at the weekend. Alex is also having good relation of their ex wife due to their daughter because his daughter need to mother love. Alex Rodriguez is a third baseman player and shortstop and played for New York Yankees of MLB. He is only man that's won a lot of awards and titles including MVP (Most Valuable Player), three American league, Silver Slugger award and two Gold Glove awards. He has also scandal among media due to some worst action with longtime exotic dancer in evening of the year 2007. So it's a major thing for all fans that who is Alex Rodríguez dating now and second thing is Alex Rodríguez EX Girlfriends List Wife because he has number of pretty girls collection in her love box.


Create a hockey clothing brand thats fun!
andrewGg brauchte ein neues Logo Design und hat einen Wettbewerb auf 99designs gestartet.
2 Gewinner wurden aus 33 Designs von 8 Designern ausgewählt.
Let the game have flow.
Looking at online selling of hockeyhare.com clothing for ages between 8 to 25. A cartoon style rabbit playing hockey with long hair coming out of the back of his helmet would be an ideal logo.