text:
Q: Replace largest value in a row with a specific number and replace all other values in that same row based on that largest value using dplyr I have a data frame consisting of questionnaire data, with each column representing one item on the questionnaire.
The data looks something like the following:
df <- data.frame(Q1a = c(3, 2, 5, 6, 9), Q1b = c(2, 0, -2, 0, 9), Q2a = c(1, 4, 7, 2, 4),
             Q2b = c(0, 0, -1, 0, 0), Q3a = c(5, 7, 2, 0, 9), Q3b = c(-2, -2, 3, 6, 9),
             Q4a = c(5, 2, 4, 9, 0), Q4b = c(0, 0, -2, -2, -2))

Each questionnaire item has two versions (a, b). I want to select all the items that possess a "b" suffix. For those columns with a "b" suffix, I want to divide the number of cells with a value of -2 against the total number of non-blank and non-NA in that particular column. I want to repeat the above procedure for all columns. I managed to accomplish it with the following code:
test <- df %>%
  select(ends_with("b")) %>%
  mutate_all(funs(round(sum(. == -2)/sum(. != "" | . != NA)*100,
                        digits = 2)))

As there is no "group_by" equivalent that I know of that works on columns instead of rows, the same results are repeated in every row of the above output. I have managed to remove the rows with the repeated information with slice, using the following code:
test <- df %>%
  select(ends_with("b")) %>%
  mutate_all(funs(round(sum(. == -2)/sum(. != "" | . != NA)*100,
                        digits = 2))) %>%
  slice(1)

With the above output, I want to continue my dplyr pipe by replacing the largest value in that row with the value of 1, and all other values as a percentage of the largest value.
What I have is the following:

The output I want is:

My two questions are:
1). Is there a group_by equivalent that works on columns? If so, I wouldn't have to use slice in such a clumsy manner.
2). Could someone help me complete my dplyr pipe to the output that I want? I am not sure how to proceed from there.
Thanks!

A: first, gather your data in long format, then filter NA and 0-values.
Than you can group and summarise.
library(tidyverse)
df %>%
  select(ends_with("b")) %>%
  gather() %>%
  filter( !value == 0 | is.na( value ) ) %>%
  group_by( key ) %>%
  summarise( output = round( 100 * length( value[value == -2] ) / n(), digits = 1 ) )

# # A tibble: 4 x 2
# key   output
# <chr>  <dbl>
# 1 Q1b     33.3
# 2 Q2b      0
# 3 Q3b     40
# 4 Q4b    100

Please note that the outcome of Q3b differs from your desired output. Are you sure the desired output is correct?

A: It's always preferable to work on data in long format. But if 3000+ columns are there in data.frame and OP wants work on data in wide format itself then one solution can be to use dplyr::summarise_all instead of mutate_all as used by OP:
library(dplyr)

df %>%
  select(ends_with("b")) %>%
  summarise_all(funs(round(sum(. == -2)/sum(!is.na(.))*100,
                        digits = 2))) %>%
  mutate(maxV = max(.)) %>%
  mutate_all(funs(100*./maxV)) %>%
  select(-maxV)

#     Q1b Q2b   Q3b Q4b
# 1 33.33   0 66.67 100


text:
Home > Blog > Paris Agreement: Getting Closer to "Entering into Force" this Year
Paris Agreement: Getting Closer to "Entering into Force" this Year
by Eliza Northrop - July 28, 2016
Solar panels in Baleia, Brazil. Photo by Riosolar/Wikimedia Commons
Over the past two months, Cameroon, Brazil, Iran and Ukraine took important steps domestically to formally join the Paris Agreement, following the 20 countries that have already done so (Peru joined on July 26). If an additional 23 other nations follow through on their promises to join this year, countries representing about 54 percent of global emissions will have joined the Agreement, putting "entry into force" well within reach. The Paris Agreement takes effect once 55 Parties representing at least 55 percent of global emissions join.
What Recent Actions Have Countries Taken to Join the Paris Agreement?
Before countries officially join the Agreement by submitting their "instruments of ratification, acceptance or approval" to the UN Secretary General, they must complete whatever domestic approval processes are required by their national constitutions and laws. Cameroon, Brazil, Iran and Ukraine recently completed these steps:
Cameroon's National Assembly approves ratification: On June 10th, members of Cameroon's bicameral National Assembly adopted the bill authorizing the President of the Republic, Paul Biya, to join the Paris Agreement. Although Cameroon accounts for only 0.45 percent of total greenhouse gas emissions, once it deposits its instrument of ratification, it would be the second African country to formally join the Agreement, following Somalia.
Brazil's House of Representatives unanimously approves joining: The House of Representatives (the lower house of Brazil's bicameral National Congress) unanimously approved the country joining the Paris Agreement on July 12th. Next, it will go to the Senate, where if approved by an absolute majority, it will take the form of a legislative decree. Legislative decrees are the last formal step required, but in accordance with custom it is likely a further Decree of Promulgation will be issued by Brazil's Acting President Temer. This process could be completed this year, enabling Brazil to deposit its instrument of ratification and formally join the Paris Agreement. Brazil is the world's seventh-largest emitter, and accounts for 2.48 percent of total global emissions.
Iran's Cabinet of Ministers ratifies the Agreement: Iran's Cabinet, headed by President Hassan Rouhani, ratified the Paris Agreement on July 13th and sent it for final approval to the Majles, Iran's unicameral legislative body. Once it receives the approval of the Maijles, the requisite instrument must be signed by the President and deposited with the UN. Iran accounts for 1.3 percent of total global emissions.
Ukraine adopts law to ratify: On July 14th, 279 members of Ukraine's unicameral legislature, the Verkhovna Rada, voted to adopt a law ratifying the Paris Agreement. All that remains is for the country to deposit its instrument of ratification. Ukraine accounts for 1.04 percent of emissions.
Crossing the 55 Percent Threshold
Even with the addition of these four nations, as well as the 20 nations that already joined and the 23 that have publicly committed to join this year—including major emitters like China, United States, Mexico, Canada and Australia–the world would still be 1.05 percent short of the 55 percent threshold.
So where could the remainder come from?
In addition to those that have committed to join this year, a number of other large emitters have sent positive signals in national statements of their intent to join in a timely manner. These include India, Russia, Japan, Saudi Arabia and New Zealand. If a combination of these countries were to join this year, we would easily exceed the 55 percent of emissions needed for the Agreement to take effect. Explore the Paris Agreement Tracker to identify different possible combinations to reach this threshold.
Furthermore, if the 55/55 threshold is reached by October 7th of this year, the first meeting of the Parties to the Paris Agreement would be held in conjunction with COP22 in Marrakech in November. Parties would then need to determine a process for adopting the key procedures and guidelines to implement the Paris Agreement.
Such rapid entry into force would continue the momentum created at Paris last year, help spur early implementation, and reinforce the global commitment to building a zero-carbon, climate-resilient future.
Tags: cop21, paris agreement, climate change, international climate policy, UNFCCC
Paris Agreement Takes First Steps Forward at Bonn Climate Talks
What's Next? EU, US and Colombia Show They're Moving Forward with the Paris Agreement
Carbon Capture and Storage: Prospects after Paris
6 Climate Milestones Since COP21 in Paris
After COP21: 7 Key Tasks to Implement the Paris Agreement

redpajama_set_name: RedPajamaCommonCrawl


text:
Bailey Whitney, Columbia Basin, Women's Soccer
BAILEY WHITNEY
COLUMBIA BASIN • FRESHMAN • MIDFIELDER
Warden High School • Warden, WA
Whitney tallied an assist in sixth-ranked CBC's 2-1 win over Wenatchee Valley and the game winning goal in a 1-0 victory over seventh-ranked Yakima Valley to help the Hawks improve to 12-1-2 on the season.
"Bailey has been a strong force in the center of the park for us this season thus far," said Hawks head coach Omar Anderson. "She got an assist to open the scoring midweek and a game winner on Saturday. She is strong in the air and technically sound. Bailey plays a quiet game but possesses a big presence for the Hawks in midfield."


text:
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India, my Love|Jul 23, 2011 2:34 PM| by: guest
Nalanda and the Pursuit of Science
(This is a transcription of Dr. Amartya Sen's keynote address at the 98th Indian Science Congress in Chennai.)
The subject of this talk is Nalanda and the pursuit of science, but before I go into that rather complex issue, I must say something about Nalanda itself, since it is still an obscure entity for most people in the world. Since the university is being, right now, re-established under a joint Asian initiative, the fact that Nalanda was a very ancient university is becoming better known. But how does it compare with other old universities in the world?
Well, what is the oldest university in the world? In answering this question, one's mind turns to Bologna, initiated in 1088, to Paris in 1091, and to other old citadels of learning, including of course Oxford University which was established in 1167, and Cambridge in 1209. Where does Nalanda fit into this picture? "Nowhere" is the short answer if we are looking for a university in continuous existence.
Nalanda was violently destroyed in an Afghan attack, led by the ruthless conqueror, Bakhtiyar Khilji, in 1193, shortly after the beginning of Oxford University and shortly before the initiation of Cambridge. Nalanda University, an internationally renowned centre of higher education in India, which was established in the early fifth century, was ending its continuous existence of more than seven hundred years as Oxford and Cambridge were being founded, and even compared with the oldest European university, Bologna, Nalanda was more than six hundred years old, when Bologna was born. Had it not been destroyed and had it managed to survive to our time, Nalanda would be, by a long margin, the oldest university in the world. Another distinguished university, which did not stay in existence continuously either, viz. Al-Azhar University in Cairo, with which Nalanda is often compared, was established at a time, 970 AD, when Nalanda was already more than five hundred years old.
That is enough vaunting of age (as you know, in India we take age quite seriously), and I hope you have got the point: we are talking about the oldest university in the world by a long margin, that is, if we do not insist on continuous existence. The university is being re-started right now, and since I happen to have the difficult task of chairing its interim governing body, I am finding out how hard it is to re-establish a university after an 800 year hiatus. But we are getting there. This meeting here gives me an opportunity to recollect the pursuit of science in old Nalanda which will inspire and guide our long-run efforts in new Nalanda. I say long run, because mainly for cost reasons – indeed entirely for cost reasons – we cannot start the science faculties immediately (physical and biological sciences cost much more money than the humanities and the social sciences do). The recollection – and more challengingly, assessment – of the scientific tradition in old Nalanda are important right now, partly because we have to start thinking about the long run (even as we try to raise money for initiation and expansion), but also because a scientific attitude and disciplined thought are important for the entire conception of new Nalanda, including the teaching of – and research in – humanities (such as history, languages and linguistics, and comparative religion), as well as the social sciences and the world of practice (such as international relations, management and development, and information technology).
Let me identify a few questions about the pursuit of science in Nalanda. First, was the old Nalanda sufficiently large to be a factor in whatever pursuit it might have been championing? Was it not merely a drop in an ocean of superstition and ignorance that some people see as the characteristic feature of the Indian old world: you only have to read James Mill's "History of India," which was obligatory reading for all British civil servants sent off to run the Raj, to see how firm and politically important this conception of the past was in keeping modern India in check.
Well, Nalanda was an old centre of learning that attracted students from many countries in the world, particularly China and Tibet, Korea and Japan, and the rest of Asia, but a few also from as far in the west as Turkey. Nalanda, a residential university, had at its peak 10,000 students, studying various subjects. Chinese students in particular, such as Xuanzang and Yi Jing in the seventh century, wrote extensively on what they saw and what they particularly admired about the educational standards in Nalanda. Incidentally, Nalanda is the only non-Chinese institution in which any Chinese scholar was educated in the history of ancient China.
It is also important to recognise that while Nalanda was very special, it was still a part of a larger tradition of organised higher education that developed in that period in India – in Bihar in particular. In addition to Nalanda, there were in the vicinity other such institutions, such as Vikramshila and Odantapuri. Indeed, Xuangzang wrote about them too, even though he himself studied in Nalanda. There was a larger social culture to which Nalanda belonged, and this is important to recollect in thinking about the tradition of Nalanda.
The second question to ask is the difficult one about the room for science in what was after all a religious institution. Nalanda was a Buddhist foundation, as were Vikramshila and Odantapuri, and surely the central focus of these institutions were studies of Buddhist philosophy and practice. The point to remember here is that by the nature of the philosophy of Buddha, whose focus of preaching was on enlightenment (the name given to Gautama, viz Buddha, itself means "enlightened"), there was a basic epistemic and ethical curiosity in the tradition of intellectual Buddhism that sought knowledge in many different fields. Some of the fields were directly related to Buddhist commitments, such as medicine and healthcare; others went with the development and dissemination of Buddhist culture, such as architecture and sculpture; and still others linked Buddhist intellectual queries with interest in analytical discipline.
Let me comment briefly on the last – not specifically with reference to Nalanda, but as a way of understanding better the Buddhist intellectual impact. One of the connections on which evidence of intellectual connections between China and India is plentiful is the impact of Buddhists in general, and of adherents of Tantric Buddhism in particular, on Chinese mathematics and astronomy in the seventh and eighth centuries, in the Tang period. Yi Jing, who was a student of Nalanda, and to whom I referred earlier, was one of many translators of Tantric texts from Sanskrit into Chinese. Tantrism became a major force in China in the seventh and eighth centuries, and had followers among Chinese intellectuals of the highest standing. Since many Tantric scholars had a deep interest in mathematics (perhaps connected, at least initially, with Tantric fascination with numbers), Tantric mathematicians had a significant influence on Chinese mathematics as well.
Indeed, as Joseph Needham notes, "the most important Tantrist was I-Hsing (+672 to +717), the greatest Chinese astronomer and mathematician of his time." Needham goes on to remark that "this fact alone should give us pause, since it offers a clue to the possible significance of this form of Buddhism for all kinds of observational and experimental sciences." Yi Xing (or I-Hsing, to use Needham's spelling), who was in fact never a student of Nalanda, but belonged to a tradition of which Nalanda was one of the results, was fluent in Sanskrit. (I request the audience to be careful of the distinction between Yi Xing, the mathematician, and Yi Jing, the intellectual trained in Nalanda, who was, among other things, interested in medicine.) As a Buddhist monk, Yi Xing was familiar with the Indian religious literature, but he had acquired a great expertise also on Indian writings on mathematics and astronomy. Despite his own religious connection, it would be a mistake to assume that Yi Xing's mathematical or scientific work was somehow motivated by religious concerns.
As a general mathematician who happened to be also a Tantrist, Yi Xing dealt with a variety of analytical and computational problems, many of which had no particular connection with Tantrism or Buddhism at all. The combinatorial problems tackled by Yi Xing included such classic ones as "calculating the total number of possible situations in chess." Yi Xing was particularly concerned with calendrical calculations, and even constructed, on imperial order, a new calendar for China.
Calendrical studies in which Indian astronomers located in China in the eighth century, along with Yi Xing, were particularly involved, made good use of the progress of trigonometry that had already occurred in India by then (going much beyond the original Greek roots of Indian trigonometry). The movement east of Indian trigonometry to China was a part of a global exchange of ideas that also went West around that time. Indeed, this was also about the time when Indian trigonometry was having a major impact on the Arab world (with widely used Arabic translations of the works of Aryabhata, Varahamihira, Brahmagupta and others), which would later influence European mathematics as well, through the Arabs (Gherardo of Cremona would make the first Latin translation of Arab mathematical texts that reported on Indian work in 1150, just before the time when Nalanda would come to its sudden end).
It is this general intellectual animation, including animation in analytical and scientific questions, that we have to appreciate in interpreting what was going on in old Nalanda. I take the liberty of mentioning here that it is not, of course, unique to Nalanda that as a religious foundation, it nevertheless pursued general intellectual and scientific studies the products of which were of great interest also to people who were not religious, or did not share the religion of the foundations involved. Isaac Newton was religious – indeed very mystically oriented – and while he revolutionised the nature of physics, mathematics and optics, he had no problem with his (and, as it happens, mine and Venky Ramakrishnan's) college's (that is Trinity's) the-then religiosity, and did not raise the kind of questions about compatibility that some later Trinity-men, like Henry Sidgwick, would with powerful arguments. The mixture of religion and science was by no means unique to Nalanda, and to illustrate with another example, it was the Christian university of Padua – one of the earliest of the extant universities in the world – that produced Galileo Galilee. (I was, incidentally amused when, while receiving an honorary doctorate at Padua, I heard Paul Ricoeur, another recipient, chastising the University of Padua for not standing up sufficiently for Galileo. Ricoeur's arguments were impeccable, though it seemed a little unfair to blame the current Rector of Padua for Padua's lack of support for Galileo.) To what extent such conflict arose in Nalanda, I do not know, but as more documents come to light, we may well find out whether there were tensions in the relation between science and religion in Nalanda. What is, however, absolutely clear is that this Buddhist foundation made much room for the pursuit of analytical and scientific subjects within the campus of Nalanda University.
A third question concerns the subjects that were actually taught in Nalanda. Here we do have a problem, since the documents in Nalanda were indiscriminatingly burnt by Bakhtiyar and his conquering army. We have to rely therefore of the accounts of students of Nalanda who wrote about what they had seen, and given the reticence of Indians to write about history (a subject of interest in itself), we have to rely mostly on the accounts of outsiders who did not share that reticence, such as Xuangzang and Yi Jing. We do know that among the subjects taught, and on which there was on-going research, were medicine, public health, architecture, sculpture, and astronomy, in addition to religion, history, law and linguistics.
What about mathematics? As it happens the Chinese chroniclers from Nalanda, such as Yi Jing and Xuangzang, were not involved in mathematical studies. Those in China who were deeply involved in Indian mathematics, such as Yi Xing, did not train in Nalanda. There may have been others, in India or China or elsewhere, from Nalanda who were involved in mathematics (a subject that was flourishing in India in this period) and whose documents have been lost. However, we do know, from Indian accounts, that logic was a subject that was taught in Nalanda, and my guess is that eventually evidence would emerge on this part of the curriculum in Nalanda as well.
Further indirect evidence in the direction of the presence of mathematics in Nalanda curriculum was the inclusion of astronomy in Nalanda. Xuangzang comments on that, and refers elegantly to the observational tower that seemed to rest among the cloudy fog high up, and provided an eye-catching sight in the Nalanda campus. In that period the progresses in Indian and Chinese astronomy were closely linked with developments with mathematics, particularly trigonometry. Indeed, all the Indian experts that the Chinese brought to China for astronomical work were mathematicians (one of these Indian mathematicians became the Director of the official Board of Astronomy of China in the 8th Century). We do not know enough about the ancestry of the Indian mathematicians who went to China to decide whether any of them had Nalanda connections, but we do know that from early fifth century Kusumpur, in nearby Pataliputra (Patna), was the place where the mathematicians doing front-line innovative work on the subject were congregating.
I end with two final remarks. The first one concerns an aspect of the intellectual life of Nalanda that emerges powerfully from the accounts we do actually have about Nalanda from Chinese as well as Indian scholars. The faculty and the students in Nalanda loved to argue, and very often held argumentative encounters. I have discussed elsewhere how deep this argumentativeness is in Indian intellectual history, but I want to add here that it is a part of the scientific tradition as well, to seek arguments and defences, refusing to accept positions and claims on grounds of faith. There were plenty of organised argumentative matches going on in Nalanda, and this too fits, in a very general way, into the scientific connections of Nalanda.
The final remark concerns the passion for propagating knowledge and understanding what Nalanda stood for. This was one reason for its keenness to accept students from abroad. Xuangzang as well as Yi Jing mentions the warm welcome they received as they arrived in Nalanda from China. Indeed, Xuangzang used this commitment in an argument with the faculty in Nalanda when he was asked – and pressed – to stay on as a faculty member in Nalanda, after he had completed his studies. He mentioned his commitment, and here he invoked Buddha himself, to spread enlightenment "to all lands." He asked the rhetorical question: "Who would wish to enjoy it alone, and to forget those who are not yet enlightened?" If the seeking of evidence and vindication by critical arguments is part of the tradition of science, so is the commitment to move knowledge and understanding beyond locality. Science has to fight parochialism, and Nalanda was firmly committed to just that.
Dr. Amartya Sen
(Dr. Amartya Sen, who won the Nobel Prize in Economics in 1998 and was awarded the Bharat Ratna in 1999, is Professor of Economics and Philosophy at Harvard University in the U.S. and chairman of the Interim Governing Board of Nalanda University.)
Tags: ancient india, education
Author: guest
© Copyright 2021 — Next Future Magazine. All Rights Reserved Designed by


text:
Q: Can I create multiple dynamic carts with Highcharts First, sorry for my bad english.
I can create DBCont number charts in different div dynamicly. Like this:
 $(function() {
    $(document).ready(function() {
        Highcharts.setOptions({
            global: {
                useUTC: false
            }
        });

        for (var g = 0; g <= DbCount; g++)
        {
            var $container = $('

').appendTo(document.body);
            new Highcharts.Chart({
                chart: {
                    renderTo: $container[0],
                    type: 'areaspline',
                    marginRight: 10,
                    zoomType: 'x',
                    spacingRight: 20,
                    events: {
                        load: function() {
                            var series = this.series[0];
                            var series2 = this.series[1];
                            setInterval(function() {
                                var x = (new Date()).getTime(),
                                        y1 = UsageGrafik[g],
                                        y2 = UsageGrafik2[g];
                                if (y1 > 120 || y2 > 120 || isNaN(y1) || isNaN(y2)) {
                                    y1 = 1;
                                    y2 = 1;
                                }
                                series.addPoint([x, y1], false, true);
                                series2.addPoint([x, y2], true, true);
                            }, 5000);
                            ....

You can see this is a dynamic chart.
My problem is setInterval(function()) sections are same for all charts. So all charts have  same graphics. Because UsageGrafik[] array is change every 5 seconds in same page with ajax.
Basicly, i want create multiple charts with different setInterval(function()) section. Or another solution. Thank you

A: It's caused by closures. You have two options:

*

*wrap creating chart into function: (function(g) { new Highcharts.Chart(...) })(g)

*move out setInterval from definition:
    new Highcharts.Chart({
        chart: {
            myIndex: g
            renderTo: $container[0],
            events: {
                load: updateChart
            }
        },
        ...
    });

    function updateChart(e) {
                    var series = this.series[0];
                    var series2 = this.series[1];
                    var g = this.userOptions.chart.myIndex;
                    setInterval(function() {
                        var x = (new Date()).getTime(),
                                y1 = UsageGrafik[g],
                                y2 = UsageGrafik2[g];
                        if (y1 > 120 || y2 > 120 || isNaN(y1) || isNaN(y2)) {
                            y1 = 1;
                            y2 = 1;
                        }
                        series.addPoint([x, y1], false, true);
                        series2.addPoint([x, y2], true, true);
                    }, 5000);
                    ....
     }

redpajama_set_name: RedPajamaStackExchange


text:
The Daily Dirt: Inside the Corcoran "hack"
Oct.October 03, 2019 11:15 AM
By Kathryn Brenzel
Pam Liebman (Illustration by Chari Tsevis)
Companies typically keep broker splits under wraps. A recent leak offered a rare look into how one of the city's biggest firms pays its brokers.
Last month documents detailing broker splits, marketing budgets and gross commission income were leaked to every Corcoran Group agent. Reporters E.B. Solomont and Erin Hudson took a deeper look at the materials, which Corcoran claimed had been hacked and were inaccurate. (The reporters kept names out of it and focused on the numbers.)
There are a few major takeaways from the report. Brokers at the firm take home 45 percent to 85 percent of the firm's fee, which is based on sales price. According to the leaked data, the average split company-wide was 60.3 percent.
One-third of Corcoran's gross commissions came from only 37 of its 1,239 brokers. Crucially, the leaked documents show some of the perks Corcoran has offered to agents. Marketing budgets range from $2,000 to $120,000, and seven agents had access to discretionary funds ranging from $5,000 to $275,000. There's also an extra bonus, dubbed "Normandy Advance Payment," which is offered to new agents to make up for any business they lost at their old firm by moving to Corcoran. The highest of these bonuses was $500,000.
Such benefits are critical for retaining agents and keeping them from being recruited away by other firms in an industry rife with poaching. In 2018, Corcoran gained 372 agents but lost 380. The firm lost 97 agents to Compass alone between the end of 2017 and the end of 2018.
The three pages of "hacked" documents provide insight into the health of Corcoran and how it manages its agents. (Corcoran, which has referred to the leak as a "criminal incident" and is investigating the matter, didn't comment on a specific aspect of the report but called TRD's publication of the information "irresponsible.")
A-Rod is now focusing on a contact sport: real estate.
The retired Yankees' star founded Miami-based A-Rod Corp. in 2003 and has since purchased more than 15,000 apartments across the U.S., Katherine Kallergis reports. He's now getting more involved in South Florida and New York. His first buy in the city came in June, when he partnered with Barbara Corcoran to acquire an apartment building in the East Village. He — along with broker Adam Modlin and Stonehenge CEO Ofer Yardeni — are in contract to buy a 100-plus-unit apartment building at 340 East 51st Street. The partners are also working to raise $500 million to leverage roughly $1 billion worth of multifamily real estate purchases in the city over the next 18 months.
The former infielder said he and fiancée, Jennifer Lopez, are not looking for another apartment in New York after selling their pad at 432 Park Avenue. The couple do, however, talk business.
"Jennifer loves residential real estate. I love commercial real estate," he said. "So we make a good team there."
What we're thinking about next: What sort of changes will be made to the expiring J-51 program? Send a note to [email protected]
Residential: The priciest residential closing recorded on Wednesday was for a condo unit at 550 West 29th Street in Chelsea, at $3.1 million.
Commercial: The most expensive commercial closing of the day was for a warehouse at 46-06 57th Avenue in Maspeth, at $260.5 million.
The largest new building filing of the day was for a 14,277-square-foot apartment building at 1329 Morris Ave in Concourse. Propco Holdings filed the permit application.
The priciest residential listing to hit the market Wednesday was for a townhouse at 154 West 11th Street in Greenwich Village, at $8 million. Douglas Elliman's Bettina Gochman Schriver has the listing. — Research by Mary Diduch
A thing we've learned…
Someone made sex toys inspired by Hudson Yards. Are we surprised? No. Scandalized? No. Upset we didn't think of it first? Yes!
Design firm Wolfgang & Hite developed pink silicone versions of many buildings in the Related Companies' megadevelopment, including a butt plug shaped like Thomas Heatherwick's the Vessel, Dezeen reports. Thank you to the late architecture critic Ada Louise Huxtable for pointing out in 2008 that a pair of skyscrapers looked "in profile, alarmingly like sex toys," forever validating criticisms of boringly phallic designs.
Thank you also to Christian D'Angelo, who commented on TRD's Instagram about the story and made me cackle at my desk: "Let me know when 56 Leonard is available." Hey, Wolfgang & Hite, get on it!
Top stories from our other markets:
Forever 21's bankruptcy filing and the fast-fashion retailer's plan to shutter scores of stores nationwide has left mall landlords with millions of dollars in outstanding lease payments and millions of square feet of empty space. It now costs the L.A.-based retailer about $450 million to occupy its stores, which span 12.2 million square feet.
Seizing on the rental market boom in Chicago, developer Jim Stoller is moving forward with a plan to convert a single-room occupancy hotel in Uptown into a mixed-use apartment building. The proposal would turn the 161-unit SRO into an 80-unit rental complex.
More than $7.4 billion worth of industrial properties have traded in Los Angeles and neighboring markets this year and if that pace continues, 2019 will set a record for investment sales. Through August, sales volume has climbed 5.5 percent year over year across Greater L.A., the Inland Empire, and Orange County.
Kushner Companies is making its first big real estate play in Fort Lauderdale. The company, led by Charles Kushner, Nicole Kushner Meyer and Laurent Morali, is under contract to purchase three properties for $49 million across the street from the Virgin Trains station in downtown Fort Lauderdale's Himmarshee District.
— Compiled by Alexi Friedman
CorcoranDaily Dirt
Corcoran to shut down office in building partly owned by Barbara Corcoran
Welcome to Queens: Corcoran opens first borough outpost
Corcoran begins new lead-gen push via Facebook ads
And the resi "deal of the year" winners are…
Sign up for our fan-favorite newsletter, The Daily Dirt!
Judge rejects Realogy's bid to force $400M sale of Cartus
Corcoran exposes Bespoke's little black book in Hamptons legal battle
TRD Quarantine Cribs: Take a tour of Cathy Franklin's whiskey distillery & home


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Interview with Rebecca Harper. In today's world, the intersection of home and academic literacies often is non-existent. Yet, individuals practice sophisticated literacy skills on a daily basis. Unfortunately, these are often overlooked in lieu of traditional literacy practices. As a literacy professor, reading and writing are Rebecca Harper's areas of expertise, but she learned more from literacy tasks in real life than in courses taken during her doctoral program. Join her for a lecture in real world literacy as she shares what pinball, her mother's eulogy, and ESPN taught her about literacy and how it transformed literacy practices. Harper is and assistant professor of literacy in the Department of Advanced Studies and Innovation at Augusta University. She received her Ph.D. in Language and Literacy from the University of South Carolina. She is the author of "Content Area Writing that Rocks (and Works!)"."
Activism, Education, Health
Rebecca Harper, education, literacy
Interview with Dwayne Estes. Mr. Estes serves as executive director for SGI. For ten years Dwayne has served as Professor of Biology at APSU and was promoted to Full Professor in 2015. Grassland loss is the single greatest conservation issue currently facing eastern North American biodiversity. Southern grasslands are nearly extinct and the species that depend on them are fading fast. The Southeastern Grasslands Initiative (SGI) is a collaboration of leaders in international biodiversity conservation led by the Austin Peay State University Center of Excellence for Field Biology, in partnership with the Botanical Research Institute of Texas, North Carolina Botanical Garden, and Roundstone Native Seed. SGI seeks to integrate research, consultation, and education, along with the administration of grants, to create innovative solutions to address the multitude of complex issues facing Southeastern grasslands, the most imperiled ecosystems in eastern North America.
Activism, Environment, Global Development, Health, Philanthropy, Science
environment, conservation, ecosystem, dwayne, estes
Timothy McCarthy | Clinton School Presents
Interview with Timothy Patrick McCarthy. Timothy McCarthy is an award-winning scholar, educator, and public servant. He holds a joint faculty appointment in Harvard's undergraduate honors program in History and Literature, the Graduate School of Education, and the John F. Kennedy School of Government, where he is Core Faculty and Director of Culture Change & Social Justice Initiatives at the Carr Center for Human Rights Policy. Dr. McCarthy is also founding Faculty Convener of the Carr Center's Emerging Human Rights Leaders Program. A historian of politics and social movements, slavery and abolition, the art and literature of protest, media culture, and human rights, Dr. McCarthy is the author or editor of five books with the New Press, including The Radical Reader: A Documentary History of the American Radical Tradition (2003), Prophets of Protest: Reconsidering the History of American Abolitionism (2006), and Stonewall's Children: Living Queer History in the Age of Liberation, Loss, and Love(forthcoming). Dr. McCarthy is the host and director of A.R.T. of Human Rights, a regular public series, co-sponsored by the Carr Center and the American Repertory Theater, that brings academics, artists, and activists together to explore the relationship between art and social change. A frequent media commentator, Dr. McCarthy is featured in several documentary films, has appeared on NPR, BBC, CBS News, Air America, Bloomberg Radio, Al Jazeera, Democracy Now!, HuffPost Live, and Big Think, and has published essays in The Daily Beast, Salon, Boston Globe, Huffington Post, and The Nation.
Activism, Civil Rights, Human Rights, Education
timothy mccarthy, human rights
Nadine Strossen | Clinton School Presents
Interview with Nadine Strossen. Mrs. Strossen is Professor of Constitutional Law at New York Law School and the first woman national President of the American Civil Liberties Union, where she served from 1991 through 2008. HATE dispels misunderstandings plaguing our perennial debates about "hate speech vs. free speech," showing that the First Amendment approach promotes free speech and democracy, equality, and societal harmony. We hear too many incorrect assertions that "hate speech" — which has no generally accepted definition – is either absolutely unprotected or absolutely protected from censorship. Rather, U.S. law allows government to punish hateful or discriminatory speech in specific contexts when it directly causes imminent serious harm. Yet, government may not punish such speech solely because its message is disfavored, disturbing, or vaguely feared to possibly contribute to some future harm. Citing evidence from many countries, this book shows that "hate speech" laws are at best ineffective and at worst counterproductive. Their inevitably vague terms invest enforcing officials with broad discretion, and predictably, regular targets are minority views and speakers. Therefore, prominent social justice advocates in the U.S. and beyond maintain that the best way to resist hate and promote equality is not censorship, but rather, vigorous "counterspeech" and activism.
Activism, Human Rights, Law, Policy
nadine, strossen, law, first amendment, hate speech, activism
Jonathan Friesen | Clinton School Presents
Interview with Jonathan Friesen. Jonathan Friesen is an author, speaker, and youth writing coach from Mora, Minnesota. His first young adult novel, "Jerk, California," received the ALA Schneider Award. His recent books include "Unfolding" and "Both of Me."
Activism, Youth, Sports
jonathan friesen, sports, coach, coaching, author
Ellen Hart | Clinton School Presents
Interview with Ellen Hart, world-class runner and lawyer. Mrs. Hart is known for her incredible athletic and professional achievements while going public about her battles with bulimia. As an undergraduate student-athlete at Harvard, Hart earned eight varsity letters while competing in basketball, soccer, and track and field. She placed third to qualify in the 10K in the 1980 Olympic Trials and went on to break the world record in 20K and the United States record in 30K. Hart earned her juris doctor from the University of Colorado Law School. She was an attorney with the Denver firm of Morrison and Foerster from 1988-90 and served as Executive Director of the Community Action Program at the University of Denver from 1990-92. Hart was married to Federico Peña, the former mayor of Denver, United States Secretary of Transportation, and United States Secretary of Energy. She helped start the Eating Disorder Foundation while giving lectures and speaking publicly about her personal experiences. A movie about her life, "Dying to be Perfect: The Ellen Hart Peña Story," was released in 1996.
Activism, Health, Law, Lifestyle
ellen, hart, law, runner, running, olympic, marathon
Emily Crane Linn | Clinton School Presents
Interview with Emily Crane Linn, Executive Director of Canopy Northwest Arkansas, for NPR affiliate KUAR on Clinton School Presents, a weekly dialogue of distinguished guests that visit the Clinton School of Public Service in Little Rock, Arkansas. Nikolai DiPippa, Clinton School Director of Public Programs, sat down with Emily Crane Linn, Executive Director of Canopy Northwest Arkansas, a resettlement center that provides refugees with everything they need to build a new life: from a place to live and language classes to counselors and babysitters. They help refugees learn English, put together a resume, evaluate their degree, and prepare for the American workforce.
Activism, Civil Rights, Education, Economy, Global Development, Human Rights, Immigration, International Relations, Law, Lifestyle, Philanthropy, Policy, Politics, Poverty, Public Service, Race
Ryan Hampton | Clinton School Presents
Interview with Ryan Hampton for NPR affiliate KUAR on Clinton School Presents, a weekly dialogue with the distinguished guests that visit the Clinton School of Public Service in Little Rock, Arkansas. Nikolai DiPippa, Clinton School Director of Public Programs, sat down with Ryan Hampton, a recovery advocate. Nearly three years into recovery from a decade-long heroin addiction, Ryan Hampton is a prominent, leading face and voice of addiction and is changing the national dialog about addiction through social media. With content that reaches over 1 million people a week, Ryan has the largest following of any person in the addiction and recovery space.
He was part of the core team that released the first-ever Surgeon General's report on addiction and was singled out by Forbes as a top social media entrepreneur in the recovery movement. Ryan connects a vast network of people who are passionate about ending the drug epidemic in America. His writing on recovery and addiction related issues regularly go viral in online journals such as HuffPo and The Hill.
Activism, Health
Dan Zak | Clinton School Presents
Interview with Dan Zak, a reporter for the Washington Post, for NPR affiliate KUAR on Clinton School Presents, a weekly dialogue of distinguished guests that visit the Clinton School of Public Service in Little Rock, Arkansas. Nikolai DiPippa, Clinton School Director of Public Programs, sat down Dan Zak, author of Almighty: Courage, Resistance, and Existential Peril in the Nuclear Age. In his book, Zak writes about a book about nuclear weapons, the activists who resist them, and the bureaucracy that maintains them.
Activism, Energy, Environment, History, Policy, Security
Janine D'Anniballe | Clinton School Presents
Interview with Dr. Janine D'Anniballe, Director of Trauma Services at Mental Health Partners for NPR affiliate KUAR on Clinton School Presents, a weekly dialogue of distinguished guests that visit the Clinton School of Public Service in Little Rock, Arkansas. Nikolai DiPippa, Clinton School Director of Public Programs, sat down with Dr. Janine D'Anniballe. She's been dedicated to the prevention, treatment and training of sexual assault issues for the past eighteen years. She is the Director of Trauma Services at Mental Health Partners in Boulder Colorado. Previously, she was the Executive Director of Moving to End Sexual Assault Rape Crisis Center in Boulder Colorado.
Activism, Gender, Health, Policy, Politics, Security


Are you, or someone you know, suffering the loss of a child through abortion? A Day of Prayer & Healing for women and men who have experienced abortion will be held on Saturday, October 13, 2018 from 9 am – 5 pm. You are not alone. There is hope.
For more information and confidential registration, please contact Tara at EnteringCanaanBR@yahoo.com or 256-568-6004. All inquiries are confidential. Sponsored by the Catholic Diocese of Baton Rouge – Office of Marriage, Family and Respect Life.


You may be entitled to a reward for reporting health care fraud. Hubbard Law Firm P.C. can help.
Health care fraud costs taxpayers billions of dollars a year.
Medical fraud raises taxes and medical costs for regular Americans. With so many medical claims submitted every day, the government alone cannot make sure health care providers follow the rules. It depends on all of us to report Medicare, Medicaid, & pharmaceutical fraud and offers generous whistleblower incentives and whistleblower protections in return.
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Anyone with non-public information about a health care provider or pharmaceutical company defrauding the government can be a Medicare or Medicaid whistleblower.
Such whistleblowers are most frequently employees in the health care industry, and can include nurses, pharmacists, EMTs, pharmaceutical marketing representatives, and many other types of healthcare professionals. But anyone can be a whistleblower, employee or not.
Because the government relies on you to save taxpayers money, it offers whistleblower incentives and protections for anyone who comes forth with information about Medicare, Medicaid, or Pharmaceutical fraud under The False Claims Act. Qui Tam is a provision of the Act that allows citizens to bring fraud cases in the name of the government.
Here are some types of Medicare & Medicaid fraud and examples of recent whistleblower cases.
A whistleblower attorney can help you determine whether you have a case and can guide you through the steps that need to be taken. If you have information about Medicare, Medicaid, or Pharmaceutical fraud, call 1-877-255-2676 today or contact us.
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For help determining whether you have a health care whistleblower case, call 1-877-255-2676 today or contact us.


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ED Summons to Chidambaram's Wife: Why the Madras HC Got it Wrong
Ashish Goel Updated: 30.06.18
Opinion 7 min read
The Madras High Court, in a judgment delivered on 24 April 2018, ruled that the Enforcement Directorate (ED) was right in seeking senior advocate (and wife of Congress leader P Chidambaram) Nalini Chidambaram's personal appearance in connection with the Saradha scam at the central investigating agency's office in Kolkata.
Also Read : ED summons Chidambaram's wife Nalini in Saradha chit fund
Ms Chidambaram had filed a writ petition in the court challenging the ED summons issued to her on multiple grounds, including, importantly, that the summons were issued in blatant disregard to section 160 of the Code of Criminal Procedure (CrPC), which exempts a woman from being investigated at any place other than her place of residence (Chennai in this case).
The court in its ruling, invoked American jurist Ronald Dworkin's theory of 'constructive interpretation' to conclude that in today's India, "women are standing at par with men in all walks of life" and, therefore, the sex-based exemption enumerated in the proviso to section 160 cannot be granted in a routine manner and must instead be guided by the facts and circumstances of a given case.
However, the judgment is legally wrong, disingenuous, and compromises essential civil liberties in the pursuit of alleged state interest, that wasn't compelling enough.
Also Read : Nalini Chidambram Summoned for ED Probe in Saradha Chit Fund Scam
HC Has Misread the Act & CrPc
The Additional Solicitor General (ASG) appearing for the ED contended the exemption stipulated in the proviso to section 160 cannot be applied to economic offences being investigated under a special law, namely, the Prevention of Money Laundering Act ("Act"), which embodies its own mechanisms regarding investigation and arrest. In particular, the ASG noted that a conjoint reading of sections 71 and 65 of the Act coupled with section 5 of the CrPC makes it categorical that the provisions of the CrPC shall apply only to the extent that they are not in conflict, or otherwise inconsistent, with the explicit provisions of the Act relating to investigation and other proceedings.
The court agreed with the ASG thus: "Section 65 [of the Act] categorically enumerates that the provisions of the CrPC shall apply in so far as they are not inconsistent with the provisions of the Act. Therefore, the intention of the legislature is that certain provisions enumerated in the Act to be applied strictly and scrupulously with reference to the offences committed under the Act. In such circumstances, no person can claim any privilege or advantage from and out of the procedures contemplated under the CrPC. Even section 65 [of the Act] speaks about investigation. Therefore, in respect of the investigation, the CrPC need not be applied…"
The court's reading of the provisions of the Act and the CrPC is severely misplaced.
According to Section 4 of the CrPC, all offences shall be investigated, inquired into, tried, and otherwise dealt with in accordance with the Code – subject only to the condition that a special law applies and regulates such investigation.
In other words, only if there is an inconsistency between the provisions of the Act and the CrPc will that Act apply.
In the context of Section 160, the court constructed a mythical inconsistency where none existed – it said that the Act allows investigating officers to require the personal appearance of persons if felt necessary, whereas the CrPC exempts women from personal appearance. While at first glance this position may seem correct, in reality, there is no conflict or inconsistency between the provisions of the Act and the CrPC so far as the place of investigation of women is concerned.
It is correct that the Act does not stipulate any exemption from personal appearance to women for the purpose of investigation, but it is equally true that the Act does not specifically require personal appearance of women either – it only sets out a general procedure for investigation.
Once the Act is silent with regard to certain procedure like where to investigate a woman, one cannot but take recourse to the CrPC. In such a situation, the concession granted to women in the proviso to section 160 must apply in respect of offences investigated under the Act.
Judicial Lawmaking
In his book Law's Empire, Dworkin notes that judges, while deciding "hard cases", must view law as integrity, that is, propositions of law are true if they figure in or follow from the principles of justice, fairness, and procedural due process that provide the best constructive interpretation of the community's legal practice. Unlike what the court would have us believe, Chidambaram's case is far from being a "hard" case – it is a case involving simple facts and application of unambiguous legal provisions.
The court agreed with Chidambaram that the proviso to section 160 confers a privilege on certain persons, including women, with a view to avoiding personal inconvenience or hardship to such persons.
However, it also said that such a privilege is not absolute and can be awarded only in "genuine" cases. The court describes "genuine" cases to mean cases involving "sick" and "bedridden" women, who are "incapable" of travelling long distances to participate in investigation proceedings. The court read the words "no woman shall be required" as employed in the proviso to section 160 to mean "not required only in certain circumstances and not always."
First of all, "incapacity" is not a pre-condition to availing the benefit of the exemption – if that was what the legislature intended, it would have categorically stated so in as many words. Next, Dworkin's theory of constructive interpretation would have come to the ED's rescue had there been a dire need to – and justification for – insisting upon the personal appearance of Ms Chidambaram. The ED did not place any material on record to show that Ms Chidambaram's personal appearance was needed or justified due to some exigent reasons, not did it place materials to show that investigation at her residence is impractical or will otherwise stifle the course of investigation.
Compromising Civil Liberties
The court said that Ms Chidambaram, being a senior lawyer with an active and lucrative practice in the Supreme Court and in state High Courts, cannot be said to be incapable of attending or participating for the effective investigation of the case. The court's views are worth noting: "When the women Flying Officers of the Indian Air-Force are able to perform on par with their male colleagues, then this Court is of an opinion that in no circumstances with reference to the current day developments of our great Nation, women can never be underestimated or blindly considered as vulnerable. May be in certain circumstances in certain areas, women are vulnerable, however, not in all circumstances in all areas."
Importantly, in the present case, the constitutionality of the proviso to section 160 was not in question and it was not right for the court to read the proviso down without testing its constitutionality.
The court did not judicially review whether or not the proviso bears any connection with remedying the historical and structural subordination of women in India. For instance, the court did not cite any empirical evidence, or any evidence at all, to show that women, or working women for that matter, do not face violence, abuse or harassment at the hands of male investigating officers.
Specifically, the court could have used this case as an opportunity to examine if the proviso to section 160 simply reinforces a sexual stereotype (and therefore unconstitutional under Article 15(1)) or protects women from a historical or existing wrong (and therefore saved by Article 15(3)).
Given that affirmative action is constitutionally permissible, it would be hard to argue that a law which seeks to tackle potential abuse and harassment of female witnesses at the hands of male investigating officers is unconstitutional (especially in view of the minuscule number of women police stations and dearth of women police personnel). But that is a legal and constitutional question of law to engage with.
Courts Have Turned Constitution on Its Head
In any event, the CrPC does not exempt women from being witnesses or from being investigated at all – women, just like men, are equally answerable to investigating officers and must fully cooperate with them, failing which they would be subject to the same fate that men are otherwise subject to. The court was not right in making sweeping statements, sans reasons, that effectively re-write laws and impede upon essential civil liberties.
Articles 14 and 15(1) of the Constitution of India give us an opportunity to move away from gender stereotypes.
It is hard to be bound by the notions that women are not competent to personally appear for investigations and must be investigated within the safe corners of their homes. But it is equally true that the four groups for whom the concession in section 160 is meant for – aged, women, children and disabled – are groups who are indisputably vulnerable in our society. What section 160 does is creates a veil of safety for this group of people.
Indian courts have upheld statutory laws on criminal defamation and criminal contempt over free speech, laws criminalising homosexuality over democratic principles of equality and dignity of life, and laws aimed at tackling black money over right to privacy and liberty. That is the tragedy of our democracy today. Constitutional courts, who were once the torchbearers of our libertarian constitutional conscience, have lately, on several occasions, turned the Constitution on its head and have failed to strike an optimal balance between essential civil liberties and state interest.
(The writer is a lawyer and legal academic. He tweets at @ashish_nujs. This is an opinion piece and the views expressed above are the author's own. The Quint neither endorses nor is responsible for the same)
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The jury watched all submitted movies, scored them based on the assessment criteria talked about on this blog. We saw many clouds, plenty of keys and great heroes.
K12Blueprint is a good, free useful resource for know-how in training. There are toolkits with info and assets for developing and deploying know-how initiatives, information on selecting the best gadget for your schools, software program and apps, curriculum, information, analysis, and blogs from educators and edtech leaders. The info and sources are well timed, relevant and straightforward to use.
Another problem is the lack of a very good analysis system for teachers. A lot of teachers who aren't doing an excellent job could really care about their students. Without an effective analysis system, teachers really have no approach of realizing whether they're effective or not. About half of all lecturers depart educating within 5 years. As a end result, there are numerous inexperienced teachers in school rooms.
In this case, Agee should yield to motive, if not compassion, and use his discretion to modify the expulsion or yield to the statutory definition of a firearm to scale back the extent of Laney's offense. Role playing games (RPGs) usually use cube, many different types of die (not just six-sided) and have a good amount of math involved; Dungeons and Dragons is probably the best known RPG.
I do not necessarily agree with the conclusion of the Atlantic article that college students ought to keep away from dearer ivy league faculties though. I know individuals who have gone to these kinds of colleges and so they have a nook office with a secretary a couple of years out of faculty. So, I suppose these elite colleges pay for themselves, if you happen to select a serious that is in demand within the work world. Degrees for these schools can lead to 30% to forty% higher wage proper out of school and a larger likelihood of discovering a job, even throughout a recession.


Zeotap, mobile data platform after meeting the stringent prerequisites for establishing, implementing, maintaining and continually enhancing an information security management system (ISMS) as set forward by the International Organization for Standardization (ISO), has announced that it has been recertified for ISO/IEC 27001. Zeotap decided on this recertification to keep on assuring customers and accomplices that they can direct their business with the organization under the total affirmation of world-driving information security and protection controls.
Moreover, Zeotap embraced an extra rigorous security evaluation for the aspects of its business that make utilization of cloud services and was awarded the STAR Silver (second most elevated amount) by the Cloud Security Alliance (CSA) a free, non-benefit confirmation body. The CSA certification is just allowed on the precondition of an effective ISO confirmation and can be viewed as a supplemental layer of security.
Both certifications entail a meticulous audit in which not only technological safeguards and monitoring are assessed, but also the security of office premises, communication safeguards, quality of leadership and management and the degree to which employees are educated on the topic. zeotap was ISO-recertified in May 2018 and CSA-certified in April 2018. The process was administered by BSI. You can view the ISO certification here and CSA here.
"We frequently receive queries on our privacy and security controls from business partners, especially larger enterprise clients from industries such as telecoms. These globally-recognised certifications establish credibility and convey our commitment to ensuring our systems are second to none," he added.
In India, zeotap counts more than 200 million data profiles from relationships with three of the five largest telecom operators in the country. The company's marquee clients include the major media agencies and more than 40 of the top 100 global brands.


Then a friend showed him a syllabus for a graduate course at Harvard in East Asian Studies, and his interest in foreign cultures was piqued. It was China which hooked him in the end. Cohen had read Pearl Buck's The Good Earth, but that was about it; now he wanted to find out more, and at Harvard he "came under the spell of renowned China historian John King Fairbank," a stroke of supreme good luck for the young student. Cohen never looked back, and more than sixty years later the institute named for his old professor has published this remarkable memoir.
Paul Cohen may not have been born to history, but largely through his work a new interest in, together with a new approach to Chinese history, was born.
The biggest problem for historians of the past is that they have never themselves experienced the material about which they write, unless, of course, they were directly involved in recent events and chose to write about them. For all the others, though, there is often a wide disparity between what people at the time experienced and how the historian following on their heels interprets their experiences.
When it comes to writing about disparate cultures such as China from a Western perspective, historians are presented with a further difficulty, namely from whose point of view can they write? If we write about China, how to we shift the center from our own cultural background to a more "China-centered" perspective? Westerners might understand the Taiping Rebellion as having been led by a crazy, xenophobic, religious fanatic calling himself "God's Chinese Son", but a Chinese historian may well see the event as an attempt on the part of the Chinese to regain cultural significance in the face of what they perceived as Western imperialist designs. And what those who lived through the event (on both sides) thought about it presents yet another point of view. Other historical events, such as the Indian Mutiny, the Mahdist War in Sudan or West Indian slave uprisings raise the same or similar questions.
These observations explain why Paul Cohen (born 1934), one of the most distinguished historians of China alive today, decided to entitle his book A Path Twice Traveled.
He began publishing books about China with China and Christianity: The Missionary Movement and the Growth of Chinese Antiforeignism 1860-1870 (1963) and is still very much active today after nearly sixty years of scholarship. There is no doubt of his profound impact on the way China is now viewed by a new generation of Western historians.
This book, engagingly-written and profound, not only gives us the scholarly side of the man, but could also serve as an introduction to Cohen's work, as he discusses each of what he considers his major books and offers up interesting thoughts about the art of writing history from various perspectives. Cohen is on occasion disarmingly self-critical about what he does, giving us, for example, a chapter entitled "Limits of the China-Centered Approach", and spends a fair amount of time discussing in sometimes amusing details the problems he had with prospective publishers who often shied away from his new approaches. His enthusiasm and love for the historian's craft is what carries this book so far away from a dull academic memoir that a reader may be forgiven for forgetting that it's written by a man with such vast knowledge and profoundly serious purpose.
As a reviewer, I have often lately praised academics for writing accessibly; Paul Cohen is one of the best of them. It's important, too, for general readers to get to know more about the people who write history, and finding those that are passionately and engagingly involved in what they do and are able to express it in writing goes a long way to achieving this. Once historians have demonstrated enthusiasm, genuine love for the subject and a sincere desire to convey those feelings about history to others, readers are more likely to read what they write; all great historians from Thucydides to Gibbon to Paul Cohen himself knew that.
Cohen's method is threefold— looking at "event, experience, and myth." History isn't just a chronological series of facts to be analyzed, but it is also intimately connected with the myths that are sometimes created around these facts and the experiences of the people who lived through the history, hence the importance of "story" in his methodology, and he presents a number of stories in the book to illustrate this point. For Cohen, then, the historian has two paths to follow, based on what the word "history means," and for him it is "what happened then—what took place in the past," and "how historians view the past now." Hence A Path Twice Traveled.
This is not the place to lay out Cohen's methodology in detail, and in any case he himself does it far better than any paraphrasing could. The personality of the writer as he reveals himself in his memoir is what keeps one reading reading; it was as if he were speaking directly from the page. Cohen never shies away from discussing disappointments and even failures when it is useful to do so, giving the impression of a man whose mind is constantly evolving, never stuck in academic rigor or obfuscating theory.
the unspoken concerns and agendas of the historian … the approaches tried and later abandoned, that characterize our work but remain hidden from view.
historians must be polyglot, conversant in the language of the present but also, to the extent humanly possible, in the language of the past. And it is our need to move back and forth between these two utterly different realms.
Posted in Non-Fiction, Reviews and tagged Biography, China, Memoir. Bookmark the permalink.


text:
/*
 * fgetline.h: Utility function to read a complete line of text
 * from a file, allocating memory for it as large as necessary.
 */

/*
 * Read an entire line of text from a file. Return a dynamically
 * allocated buffer containing the complete line including
 * trailing newline.
 *
 * On error, returns NULL.
 */
char *fgetline(FILE *fp);

redpajama_set_name: RedPajamaGithub


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If you're missing teeth, smiling might be something you'd rather not do. Your black hole in your mouth is bothering you when you look in the mirror. There is a solution to take all of your social and dental fears away. The solution can be a dental implant.
An implant is an artificial tooth "root" surgically placed in your mouth. It is made of metallic (titanium) and bone-like ceramic. The implants eventually fuse with your bone to support a crown, bridge, or full denture.
You may be considering an implant for yourself. Here are some things to consider as you make your decision. If you have healthy gums you are a good candidate. You also need to have enough bone to support and implant. If you have a chronic illness like diabetes and leukemia it can interfere with the healing process of an implant. Smoking can double the risk of losing an implant altogether. Long-term steroid use, osteoporosis and other diseases that affect the bones can increase the risk of early failure of implants.
When you think of the season of fall, change comes to mind. It's a season when the leaves change, and maybe it's time for a dental change for you. A dental implant can make you feel more comfortable in social situations. Smiling without hesitation is something that none of us ever want to take for granted. Losing a tooth (or multiple teeth) can be traumatizing. Thanks to dental implants, you don't have to live with an incomplete smile.
At Lakewood Dental Trails, we'd love to discuss the long-term advantages of a dental implant with you. Call to schedule an appointment with us, and get on your way to getting your full smile back.


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Obituaries / Bernie Paul Fry
Bernie Paul Fry
From Richland, WA | Born in Weiser ID
Fri, March 18, 2022, 1:00 pm
http://www.eventsatsunset.com/
Sat, March 19, 2022, 11:00 am
Sat, March 19, 2022, 12:00 pm
Bernie Paul Fry passed away March 12th 2022 in Richland Washington. He was born on April 25th 1931 in Weiser Idaho to George Franklin & Ona Ann (Kerns) Fry. His family moved to Seaside Oregon where he attended school, graduating in 1949. Times were tough. As a student, he sold newspapers and worked as a janitor at the school. During this time, his sister Stella sent him a letter telling him about the gospel which lead to his professing to live his life for God. This purpose remained a priority throughout his life.
In 1952, Bernie met Dorothy Lulow through her friend (Pat Daniel). They corresponded while he served as a medic in Korea. They married April 3, 1954 in Seattle. The newlyweds made their first home in a 20 foot trailer in Oreck California. Bernie worked as a logger. Later, Bernie and Dorothy moved to Seattle where he became a commercial electrician. He worked on many jobs around Seattle including the Space Needle! He wisely waited to tell Dorothy about that dangerous job until after it was finished! Bernie worked in the trade for many years until retirement.
In 1968 Bernie and Dorothy built a home in Edmonds where they raised their three busy boys Steve, David, and Michael.
Bernie was a caregiver. He went to the nursing home where his mother-in-law was to feed her meals several times a day. He cared for Dorothy after her debilitating stroke for many many years. In 2012 Bernie decided it was time to move to assisted living. He and Dorothy moved to Brookdale Richland. After her death he became known as "the greeter" who helped new residents feel welcome and settle into their new environment. He would help others even when he could barely get around himself! He always had a joke to tell! We will miss you Bernie.
Bernie was preceded in death by his parents George Franklin and Ona Ann (Kerns)Fry , his wife Dorothy, siblings Paul, Erma, Ann, Thelma, Jean. He is survived by his sister Stella McDonald, brother, John Fry, sons Steve (Christie) of Richland WA. , David (Keiko) Tucson AZ. , Mike (Julie) Yakima WA., five grandchildren Justin (Britney), Andrew, Jenna, Katrien, and Madelyn, and 2 great grandchildren Henry and Murphy. He also is survived by many cousins, nieces and nephews.
In lieu of flowers please consider supporting Teepa Snows -Positive Approach to Care (Dementia) https://teepasnow.com/about/support-pac/
Bernie and Dorothy Fry were very special people. Always kind and welcoming. Glad to hear they finish their lives faithful and were Godly examples.
I met Bernie when my mother moved to Brookdale. He always had a smile on his face. I enjoyed many conversations with him over the years. It was apparent that he had lived a good life and loved his family very much.
Karen Neumayer
We were neighbors and friends in Edmonds to Bernie and Dorothy and their three boys. Our friendship spanned more than 50 years. In all that time we raised our families and shared many busy, bustling , happy years of dinner dates, meetings, conventions, birthdays, graduations, marriages, and then the joys of grandchildren. In 2002 , Dorothy had a debilitating stroke. As her caregiver, Bernie continued to be the same smiling, uncomplaining person that saw opportunities to help others. Throughout his life, he went the extra miles. We feel blessed to have had his gracious influence in our lives.
Don and Sandi Scholl
We got acquainted with Bernie and Dorothy in Seattle and so enjoyed them and admired his care for her. He will definitely be missed.
Pat Dimzoff


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Katie Breathwick 1am - 4am
Symphony No.9 in D minor Opus 125 (1) Ludwig Van Beethoven Download 'Symphony No.9 in D minor Opus 125 (1)' on iTunes
Maxim Vengerov Home
Watch Maxim Vengerov's exclusive at-home concert for Classic FM
26 March 2020, 10:44 | Updated: 27 March 2020, 17:19
Watch Maxim Vengerov's exclusive at-home concert for Classic FM. Picture: Classic FM
By Rosie Pentreath
@rosiepentreath
In the video below, Classic FM's Artist in Residence performs a special concert from a living room in Russia – for all of us working from home, self-isolating or looking after the family.
Violinist Maxim Vengerov, Classic FM's Artist in Residence, gave an exclusive online concert from a living room in Russia on Thursday (26 March), for all of us quarantined at home – watch below.
Tchaikovsky: Piano Trio, Op.50
Maxim Vengerov, violin
Boris Andrianov, cello
Peter Laul, piano
–– Intermission ––
Mozart: Violin Sonata No. 32 in B-Flat Major
Schubert: Fantasy in C major
Video: Nicolai Proleev
Announced as Classic FM's first ever solo Artist in Residence at the beginning of 2020, Vengerov aims with his Classic FM online concert 'to reach everyone at home' – especially those looking for a moment of beauty, inspiration and clarity through great music to bring light to their day. The concert features chamber works by Tchaikovsky, Mozart and Schubert.
"I am so thrilled to be Classic FM's first solo Artist in Residence," Vengerov said at the time it was announced he would be joining Classic FM. "Working so closely with Classic FM, sharing all my exciting projects with their audiences, means a lot to me."
Read more: some of the best classical music you can stream online >
Classic FM's Artist in Residence, Maxim Vengerov. Picture: Classic FM
Read more: Maxim Vengerov presents a series of exclusive violin masterclass videos for Classic FM >
Joined by cellist Boris Andrianov and pianist Peter Laul, he performs Tchaikovsky's Piano Trio, Mozart's Violin Sonata No.32 and Schubert's Fantasy in C Major.
The concert was available to watch live here at 2pm on Thursday 26 March, and can be watched above until further notice.
Please note that it includes a short intermission of 10 minutes between Vengerov's performance of the Tchaikovsky and the Mozart, to allow time for resetting the living room stage!
Maxim's performance – and the idea of giving a concert out of his home – comes very much from the heart, at a tough time when people are turning to music for support and a feeling of connection with others.
Maxim Vengerov News
See more Maxim Vengerov News
'Music education empowers kids' – violinist Maxim Vengerov
Song by Prince Albert performed at Buckingham Palace by Royal College of Music students and alumni
Maxim Vengerov to start residency in Oxford
Maxim Vengerov Pictures
See more Maxim Vengerov Pictures
Maxim Vengerov at 40: Ten facts about the great violinist


"It takes 20 years to build a reputation and five minutes to ruin it. If you think about that, you'll do things differently," Warren Buffet once said.
In this era of high-speed internet, however, it can take just seconds to ruin a company's reputation. Neglecting to properly manage your online presence can jeopardize customer trust, harming your brand and your business. Here are some online reputation killers you need to steer clear of at all costs.
Selecting the wrong person to handle your online content can be a deal breaker for many businesses, causing a serious reputation risk. Think about it—the person in charge of your social media accounts is responsible for speaking on your brand's behalf. It is vital that whoever is creating your content follows strict company guidelines, producing high-quality content that is professional and appropriate each and every time.
Ignoring or deleting negative comments can quickly come back to haunt a company, turning a good reputation bad, really quickly. If customers feel that you're dismissing their concerns and not taking them seriously, they may post damaging complaints about your business across a wide spectrum of platforms, leaving you with an unwelcome reputation impression that can be almost impossible to recover from. It is always a good idea to reply to customers as quickly as you can. By opening up the lines of communication, you could transform a complaint into a customer service opportunity, creating a positive learning experience for everyone.
Allowing yourself to be tagged in questionable photos can have serious consequences to you and your company. All it takes is just one humiliating picture or inappropriate video to annihilate your online reputation. To avoid suffering a similar fate that has plagued so many high-profile people, business owners should conduct themselves accordingly whenever cameras are present.
As tempting as it might be, exaggerating the truth or being flat out dishonest can quickly and irreparably destroy your professional reputation. Whether it's to build your traffic, increase subscribers, or attract customers, there is always a risk that lying will catch up with you, reducing your online reputation to rubble. At all times, it is best to represent yourself accurately online by being upfront and transparent.
Putting these practices into action will go a long way to helping you maintain a positive public image. For comprehensive online management tips, contact us today.


Every time I use a certain public bathroom, I am reminded of something I need to share to prepare my family and friends for when I grow older.
Hard as I try, I have a difficult time pressing the handles on a particular set of toilets. Always I dare not leave the evidence of my having used the facility, and so I repeatedly try, with all my might, to get the toilets to flush completely.
And every time I struggle thusly, I am reminded of a true story I heard at a long-term care nursing convention.
Seems as if a family was particularly grossed out when their elderly relative, whom they graciously sprang from a nursing home for a holiday visit, neglected to flush the toilet.
Not wanting to embarrass their relative, but totally disgusted, the family confronted the long-term care facility administrator.
The administrator smiled, recalling how often that same complaint was registered by other resident-springing families.
Message to loving friends and relatives: when I am older and greyer and you spring me for a visit, judge not if I forget to flush. Not flushing is not necessarily a sign of dementia or slovenliness. My daily toilet digs just might be higher-tech than yours.
Oh, and same with the faucets. If I let them continue running, please remember that mine just might turn off on their own. Love ya!
What anticipatory-explanations might you like to offer friends and relatives?
This entry was posted in Family, Retirement, Seniors. Bookmark the permalink.
Reminds me of when I have walked into doors in public, expecting them to open for me automatically. It's an interesting dichotomy of automation versus elimination of services in today's world…. Toilets flush, yet we need to pump our own gas and check out our own products. I was at a store yesterday and only self-service check- out. So even in retirement, what new skills will we need to be learning, as we can forget others?
Thank you so much, Pat, for reading/commenting. As always, great observations; great ending question!!! Guess truth is even if an old dog is put out to pasture these days, he better be able to learn new tricks. Good thing we can!!…Especially with our bright outer circle to help us stay informed and vital. God bless you! Hope all is well. Peace!


This entry was posted on viernes, diciembre 13th, 2013 at 12:42 pm	and is filed under Carpe Diem, celebración, Dimensión, Dionisio Gutiérrez, Elizabeth Hammerlin, Jorge H. López, Juan Ignacio Ardón, Luis Figueroa, Navidad, televisión. You can follow any comments to this entry through the RSS 2.0 feed. Both comments and pings are currently closed.


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#20 Midfielder - UCLA
Hometown: Tokyo, Japan
High School: Aoyamagakuin
Major: Unknown
2017 UCLA 20 3 6 0 0 0 0 - 0
01/29/2017 Cal State Long Beach W 10-9 0 1 0 0 0
02/04/2017 @ UC Santa Barbara L 1-10 0 0 0 0 0
02/11/2017 @ UNLV L 6-15 0 0 0 0 0
02/19/2017 Oregon State L 2-14 0 0 0 0 0
02/18/2017 Stanford L 4-11 0 0 0 0 0
02/25/2017 @ San Diego State L 8-14 0 0 0 0 0
02/26/2017 @ UC Irvine W 12-2 1 1 0 0 0
03/05/2017 @ Chapman L 2-18 0 0 0 0 0
03/11/2017 Dominican L 8-14 1 1 0 0 0
04/02/2017 Claremont L 7-13 0 0 0 0 0
04/13/2017 @ USC L 7-17 0 1 0 0 0


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T.J.'s Takeaways From Thursday at the Chili Bowl Nationals
_Top Features, Blog, T.J.'s Takeaways
CJ Leary (Serena Dalhamer photo)
By T.J. Buffenbarger
(January 13, 2022) — Another night of racing at the 2022 Chili Bowl Nationals and another thrilling program from start to finish. The excitement of Thursday's preliminary program provided a better boost than caffeine to plow through another night of takeaways from the racing program.
Rarely do you see the action during multiple day events in our sport crescendo with the on-track action seemingly getting better as the event going on. This year's edition of the Chili Bowl Nationals appears to be on that trajectory.
The only question I had after Thursday night's feature was, "How does the racing keep getting better as the week goes on this year?"
After what was a bit of a lack luster feature Monday (although following a stellar VIROC event) the feature racing at the Tulsa Expo Center has been excellent. I'm not sure what the track crew discovered between Monday and the rest of the week, but they should keep doing it as the on-track action has seemingly improved every night.
That point was capped off with the thrilling final laps with Christopher Bell, Tanner Thorson, and C.J. Leary's thrilling race for the win on Thursday.
The interesting part of Thursday's feature was watching the top and bottom lanes shift from being dominant during different times of the feature. The past two nights have shown moments where finding the right lane at the right time was a crucial part of the main event, but not making one line so dominant that it takes over the entire event.
If Saturday's finale has some of the aspects of the past two preliminary nights, we are all in for a treat.
While the race for the lead was good, the Buckwalter family managed to grab pieces of the spotlight as well.
Steve Buckwalter and his crew's thrash to overcome a very hard hit to the right rear of their racing with the turn one concrete wall to make the feature and finish 13th was remarkable. The amount of damage Steve's car suffered in that crash would have made it easy to throw in the towel and compete in some early letter mains on Saturday.
Steve's crew would not hear of it and not only made repairs, but got the car good enough for Steve to work some on track magic and possibly gain his crew some more rest on Saturday.
Tim Buckwalter also got in on the fun after starting 20th coming out of nowhere to finish fourth in the main event. Tim drove a smooth, steady race and somehow avoided a lot of the carnage on his way to earning hard charger honors Thursday.
The performance of Alex Bowman Racing has been eye opening this week during the Chili Bowl Nationals. Not only did Bowman increase his effort to three cars for this year's Chili Bowl including returning to the drivers seat himself, the team that primarily focuses their midget car effort to Tulsa has produced a breakout effort.
After Bowman looked sporty on Monday scoring a ninth-place finish in the feature, a fourth-place effort by Jake Swanson on Tuesday, and Leary's podium finish on Thursday ABR appears to be putting themselves in the conversation to be Chili Bowl contenders for victories in future years.
Now the question becomes can ABR get their entries into the finale on Saturday through some of the later alphabet mains.
Chili Bowl Nationals
T.J.'s Takeaways
Tulsa Expo Raceway


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Q: after install hhvm , find no folder of hhvm in /usr/share folder After install nginx and hhvm , in /usr/share folder can not find any hhvm folder so I can not run this command "sudo /usr/share/hhvm/install_fastcgi.sh" get an error : sudo /usr/share/hhvm/install_fastcgi.sh
Please help. Thanks in advance.

A: Please could you provide any details about your install process? I've just made an installation via ubuntu packages and I can find that file on my PC
ls -lrth /usr/share/hhvm/
total 16K
-rwxr-xr-x 1 root root 4,5K jul 19 20:02 uninstall_fastcgi.sh
-rwxr-xr-x 1 root root 5,6K jul 19 20:02 install_fastcgi.sh

The command to install hhvm on a Ubuntu distro is below:
sudo apt-get update
sudo apt-get install hhvm

Hope it helps. Best regards.
Javi


1. "Couldn't decode the image. decoder error 29: first chunk is not the header chunk"
If you are getting this error message in OpenGL/Metal Projects, the settings in Xcode is preventing the loading of png images.
You may get an error while opening/running the project demos. The most common issue I have seen is the "No such file or directory...xxxx-Prefix" error.
In Xcode, go to new->file->PCH File. Name the PCH file: 'NameOfProject-Prefix' where "NameOfProject" is the name of the demo you are trying to open. In the OpenGL demo projects, I usually named the projects as "openglesinc."
Make sure the file is saved within the 'NameOfProject' folder.
This should fix any issues you may have while opening the demo.
If you are getting additional errors, please contact me.


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Q: Restrict firebase database to make new nodes using firebase rules How can i restrict database to make any new nodes(from an app) in the database using firebase rules.
My database looks like this

A: I hope you have wrote rule for all the existing nodes in database, after that write the following rule for preventing creation of new nodes from android app or any other integration
  "rules": {
    "Articles": {
        ".read": //rules that you want to write
        ".write": //rules that you want to write
    }
    "Categories": {
        ".read": //rules that you want to write
        ".write": //rules that you want to write
    }
    .
    .
    //rules for other nodes in your database
    .
    .
    "$NewNode":{
        //This rule will prevent from creating new nodes
        ".read": false,
        ".write": false
    }
  }
}


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Kiev Check-In
What's New in Kiev – June 2017
What's New in Kiev
Fountains on Maidan
Photo provided by the Press-service of Kiev City State Administration
On May 1st, 2017, the Kiev City Council was proud to present a new light and music water fountain complex on Maidan Nezalezhnosti whose water jets rose up to 35 meters high!
The fountains will run every day except Monday from 11 a.m. until 11 p.m. until September 30th, 2017. The backlight will turn on daily after dark whereas light music performances will be held twice a week on Friday and Saturday in the evening.
For three years the Kiev Fountains on Maidan Nezalezhnosti were still; During their reconstruction, new networks were set and granite elements changed along with the installation of an automatic audio system.
Velodrome was Opened after Reconstruction
Photo provided by @velodrome.kiev
On May 20, the Mayor of Kiev, Vitali Klitschko, officially opened the Kyiv Velodrome in 58 Bogdana Khmelnytskogo Str. (Kiev city center) after nearly 10 years of reconstruction! Built in 1912, it is one of the oldest bicycle tracks in Europe. Here you can find spaces for cycling under the open sky, a variety of gyms, boxes for storing your bike, underground parking, and cafeteria.
At the opening celebration, there was a magnificent laser-light show, a 3D video installation, colorful circus performances with the participation of professional acrobats, dancers, mimes, and singers. The real culmination of the event – a large-scale dance flashmob accompanied by famous music hits that was an amazing way to relaunch Kyiv Velodrome!
One SIM card for 229 countries!
International telecom company Drimsim is launching a SIM card in the Ukraine that can work in 229 countries worldwide! The card costs EUR 10 with an average price of 1-2 euro cents for 1 megabyte and around 35 euro cents for 1 minute of GSM conversation.
The SIM card operates via a smartphone app available for Android and iOS devices. Through the mobile application, you can check each country's mobile tariffs, remaining cash on your sim card as well as get online support 24 hours a day.
Copyright © 2015-2016 KievCheckIn.com. All rights reserved. Terms of Use


Kali Uchis and Jorja Smith have announced a joint tour. The aptly named "Kali & Jorja" Tour kicks off April 28 with a show at the Anthem in Washington, D.C., and will take the duo across North America. Other cities on the schedule include Boston, Philadelphia, NYC, Houston, Vancouver, Chicago, and more. Check out the full itinerary below.
Jorja Smith was recently nominated for the Grammy Award for Best New Artist, her first-ever nomination. She's touring behind her debut album Lost & Found, released last year. Kali is touring behind her own debut, Isolation, also released in 2018.


The use of genetically modified cells for therapeutic purposes is an increasing trend that shows great promise. The major hurdle in genetic modification of human cells is the delivery of the gene-of-interest into the cell. Currently, viral vectors are most commonly used for ex vivo genetic modification of human cells but there's very little information about the intracellular immune response pathways triggered by viral vector entry. With the help of advancing next generation sequencing technologies, genome-wide loss-offunction screens have the capacity to produce crucial data to enlighten several unknowns and characterize function of genes comprehensively. The CRISPR/Cas9 system was recently adapted into genome-wide screens and shows great potential in characterizing complex phenotypes. In this study, we used the efficient and high throughput genome editing ability of CRISPR/Cas9 system to discover NK cell resistance mechanisms to lentiviral gene delivery. NK cells are part of innate immune system that act as a first line of defense against viruses. Using NK cells as an immunotherapy agent is not a new idea but genetic modification of NK cells using lentiviral vectors is a very tough task due to its fully armed nature against viral agents. In order to reveal which antiviral pathways become triggered in NK cells during viral vector entry to the cell, we used Genome-scale CRISPR Knock-Out Libraries(GeCKO). Using a controlled experiment setup; we were able to identify candidate pathways like RIG-I/MDA5 type I interferon secretion and also Toll like receptor (TLR) related pathways that may block virus entry as well as mechanisms that are used by lentiviral vectors to manipulate host cells. Also several genes, like S100A12, I BCL10 and APOB were shown significantly changed during viral vector entry, which implicate some novel pathways in NK cells against lentiviral vectors. Mapping these pathways is the first step in the venture of overcoming the intracellular defense mechanisms against gene delivery vectors. Identification and manipulation of these pathways could lead to a dramatically increased delivery rate of the transgene, making gene therapy protocols safer and more effective. This may have broad technical applications in order to improve the efficiency of genetic modification of a wide variety of cell types.
Yükseköğretim Kurulu Tez Merkezi Tez No: 478687.
NK Cells. -- Lentiviral vectors. -- Antiviral immunity. -- GeCKO library. -- CRISPR. -- NGS. -- NK Hücreleri. -- Lentiviral vektörler. -- Antiviral bağışıklık. -- GeCKO kütüphanesi.


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Slater nears historic landmark OK
Official designation could help land significant funding for Albany tourist site
ALBANY -- Just in time for Memorial Day, the USS Slater museum ship has cleared a significant hurdle in its quest to be named an official historic landmark by the National Park Service.
Leaders of the Destroyer Escort Historical Museum -- the nonprofit that maintains the Slater -- were in Washington, D.C., to receive the news Tuesday that the Park Service's landmarks advisory committee had voted unanimously to approve its application.
U.S. Sen. Kirsten Gillibrand's office released a letter Friday the Democrat sent to Paul Loether, chief of the National Register of Historic Places and National Historic Landmarks Program, urging him to look favorably on the Slater's application as it moves through the Park Service.
"While berthed in the Hudson River, the USS Slater has become a very popular destination," Gillibrand wrote, "and achieving this designation has the potential to greatly enhance tourism and economic activity in the surrounding area."
The World War II-era destroyer escort has been a fixture of the Albany waterfront for 14 years, during which time it has been refurbished to approximate its original condition. After the war, the Slater was handed off to the Greek navy, where it was in service for four decades.
Tim Rizzuto, executive director of the museum, said a final decision was likely in 2012.
As with many government processes, the machinery can move slowly. One of the advisory board's members jokingly told Rizzuto, "Don't run out and get the plaque."
While landmark status doesn't come with any federal commitment of funds, "When you apply for grants, being able to check that box can give you a leg up," Rizzuto said, adding "Preservation money has really dried up over the past few years."
The Slater spends the worst part of the winter berthed on the Rensselaer side of the Port of Albany. Rizzuto said a bulkhead that would deflect ice away from the Slater and its portion of the seawall and allow it to remain in its current location permanently would cost in the neighborhood of $700,000.
Rizzuto said the Slater attracts around 15,000 visitors a year.
There are more than a 130 designated historic landmarks in upstate New York. In the Capital Region, they range from Fort Crailo in Rensselaer to Nott Memorial on the Union College campus in Schenectady.
For information on visiting the USS Slater, visit http://www.ussslater.org/
The Slater recently received its permanent charter from the state Board of Regents, which determines what entities can claim status as museums.
Reach Seiler at 454-5619 or cseiler@timesunion.com.