text:
package com.hubspot.singularity.scheduler;

import io.dropwizard.db.DataSourceFactory;

import java.util.concurrent.TimeUnit;

import org.apache.mesos.Protos.TaskState;
import org.junit.Assert;
import org.junit.Test;

import com.google.common.base.Optional;
import com.google.inject.Inject;
import com.hubspot.singularity.SingularityRequestHistory.RequestHistoryType;
import com.hubspot.singularity.SingularitySchedulerTestBase;
import com.hubspot.singularity.SingularityTask;
import com.hubspot.singularity.data.history.SingularityRequestHistoryPersister;
import com.hubspot.singularity.data.history.SingularityTaskHistoryPersister;

public class HistoryPersisterTest extends SingularitySchedulerTestBase {

  @Inject
  protected SingularityRequestHistoryPersister requestHistoryPersister;
  @Inject
  protected SingularityTaskHistoryPersister taskHistoryPersister;
  @Inject
  protected SingularityCleaner cleaner;

  @Test
  public void testRequestPurging() {
    initRequest();

    configuration.setDeleteStaleRequestsFromZkWhenNoDatabaseAfterHours(7);

    requestHistoryPersister.runActionOnPoll();

    Assert.assertTrue(!requestManager.getRequestHistory(requestId).isEmpty());

    requestManager.deleteRequest(request, user);

    requestManager.deleteHistoryParent(requestId);

    requestManager.activate(request, RequestHistoryType.CREATED, System.currentTimeMillis() - TimeUnit.HOURS.toMillis(3), Optional.<String> absent());
    requestManager.cooldown(request, System.currentTimeMillis() - TimeUnit.HOURS.toMillis(2));

    requestHistoryPersister.runActionOnPoll();

    Assert.assertTrue(!requestManager.getRequestHistory(requestId).isEmpty());

    configuration.setDeleteStaleRequestsFromZkWhenNoDatabaseAfterHours(1);

    requestHistoryPersister.runActionOnPoll();

    Assert.assertTrue(requestManager.getRequestHistory(requestId).isEmpty());
  }

  @Test
  public void testTaskPurging() {
    initRequest();
    initFirstDeploy();

    SingularityTask taskOne = launchTask(request, firstDeploy, System.currentTimeMillis() - TimeUnit.HOURS.toMillis(3), 1, TaskState.TASK_RUNNING);
    SingularityTask taskTwo = launchTask(request, firstDeploy, System.currentTimeMillis() - TimeUnit.HOURS.toMillis(3), 2, TaskState.TASK_RUNNING);

    taskHistoryPersister.runActionOnPoll();

    Assert.assertTrue(taskManager.getTaskHistory(taskOne.getTaskId()).isPresent());
    Assert.assertTrue(taskManager.getTaskHistory(taskTwo.getTaskId()).isPresent());

    configuration.setDeleteTasksFromZkWhenNoDatabaseAfterHours(1);

    taskHistoryPersister.runActionOnPoll();

    Assert.assertTrue(taskManager.getTaskHistory(taskOne.getTaskId()).isPresent());
    Assert.assertTrue(taskManager.getTaskHistory(taskTwo.getTaskId()).isPresent());

    statusUpdate(taskOne, TaskState.TASK_FINISHED, Optional.of(System.currentTimeMillis() - TimeUnit.HOURS.toMillis(2)));

    taskHistoryPersister.runActionOnPoll();

    Assert.assertTrue(taskManager.getTaskHistory(taskOne.getTaskId()).isPresent());
    Assert.assertTrue(taskManager.getTaskHistory(taskTwo.getTaskId()).isPresent());

    cleaner.drainCleanupQueue();

    taskHistoryPersister.runActionOnPoll();

    Assert.assertTrue(!taskManager.getTaskHistory(taskOne.getTaskId()).isPresent());
    Assert.assertTrue(taskManager.getTaskHistory(taskTwo.getTaskId()).isPresent());
  }

  @Test
  public void testPurgingDoesntApplyIfDatabasePresent() {
    initRequest();
    initFirstDeploy();

    requestManager.deleteRequest(request, user);

    requestManager.deleteHistoryParent(requestId);

    requestManager.activate(request, RequestHistoryType.CREATED, System.currentTimeMillis() - TimeUnit.HOURS.toMillis(3), Optional.<String> absent());

    configuration.setDatabaseConfiguration(new DataSourceFactory());

    configuration.setDeleteStaleRequestsFromZkWhenNoDatabaseAfterHours(1);

    requestHistoryPersister.runActionOnPoll();

    Assert.assertTrue(!requestManager.getRequestHistory(requestId).isEmpty());
  }

}


text:
Mal de Meleda
Mal de Meleda is a rare skin disorder that begins in early infancy. Affected individuals have a condition known as palmoplantar keratoderma, in which the skin of the palms of the hands and soles of the feet becomes thick, hard, and callused. In mal de Meleda, the thickened skin is also found on the back of the hands and feet and on the wrists and ankles. In addition, affected individuals may have rough, thick pads on the joints of the fingers and toes and on the elbows and knees. Some people with mal de Meleda have recurrent fungal infections in the thickened skin, which can lead to a strong odor. Other features of this disorder can include short fingers and toes (brachydactyly), nail abnormalities, red skin around the mouth, and excessive sweating (hyperhidrosis).
Mal de Meleda is a rare disorder; its prevalence is unknown. The disorder was first identified on the Croatian island of Mljet (called Meleda in Italian) and has since been found in populations worldwide.
Mal de Meleda is caused by mutations in the SLURP1 gene. This gene provides instructions for making a protein that interacts with other proteins, called receptors, and is likely involved in signaling within cells. Studies show that the SLURP-1 protein can attach (bind) to nicotinic acetylcholine receptors (nAChRs) in the skin. Through interaction with these receptors, the SLURP-1 protein is thought to be involved in controlling the growth and division (proliferation), maturation (differentiation), and survival of skin cells.
Mutations in the SLURP1 gene lead to little or no SLURP-1 protein in the body. It is unclear how a lack of this protein leads to the skin problems that occur in mal de Meleda. Researchers speculate that without SLURP-1, the activity of genes controlled by nAChR signaling is altered, leading to overgrowth of skin cells or survival of cells that normally would have died. The excess of cells can result in skin thickening. It is unclear why skin on the hands and feet is particularly affected.
Learn more about the gene associated with mal de Meleda
SLURP1
Genetic Testing Registry: Acroerythrokeratoderma
Foundation for Ichthyosis and Related Skin Types: Palmoplantar Keratodermas
acroerythrokeratoderma
keratosis palmoplantaris transgrediens of Siemens
Meleda disease
transgrediens palmoplantar keratoderma of Siemens
Health Information from MedlinePlus (1 link)
Health Topic: Skin Conditions
Centre for Arab Genomic Studies (PDF)
MalaCards: mal de meleda
Orphanet: Mal de Meleda
Foundation for Ichthyosis and Related Skin Types
Resource List from the University of Kansas Medical Center: Dermatology and Genetics
Arredondo J, Chernyavsky AI, Webber RJ, Grando SA. Biological effects of SLURP-1 on human keratinocytes. J Invest Dermatol. 2005 Dec;125(6):1236-41.
Chimienti F, Hogg RC, Plantard L, Lehmann C, Brakch N, Fischer J, Huber M, Bertrand D, Hohl D. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda. Hum Mol Genet. 2003 Nov 15;12(22):3017-24. Epub 2003 Sep 23.
Eckl KM, Stevens HP, Lestringant GG, Westenberger-Treumann M, Traupe H, Hinz B, Frossard PM, Stadler R, Leigh IM, Nürnberg P, Reis A, Hennies HC. Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates. Hum Genet. 2003 Jan;112(1):50-6. Epub 2002 Oct 19.
Favre B, Plantard L, Aeschbach L, Brakch N, Christen-Zaech S, de Viragh PA, Sergeant A, Huber M, Hohl D. SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda. J Invest Dermatol. 2007 Feb;127(2):301-8. Epub 2006 Sep 28.
Fischer J, Bouadjar B, Heilig R, Huber M, Lefèvre C, Jobard F, Macari F, Bakija-Konsuo A, Ait-Belkacem F, Weissenbach J, Lathrop M, Hohl D, Prud'homme JF. Mutations in the gene encoding SLURP-1 in Mal de Meleda. Hum Mol Genet. 2001 Apr 1;10(8):875-80.
Reviewed: November 2014

redpajama_set_name: RedPajamaCommonCrawl


What do investors want to see in company tax disclosures?
In this Investor view, we share some insights from recent discussions with shareholders, investors and analysts that can help companies consider the key messages they need to convey in their tax reporting.
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text:
#FightCOVID19 Let's Fight Coronavirus Together!
Home COVID-19 2020 nearly Earth's hottest year on record as global warming continues
2020 nearly Earth's hottest year on record as global warming continues
"Whether one year is a record or not is not really that important – the important things are long-term trends."
Overall, Earth's average temperature has risen more than 2 degrees since the 1880s, NASA said.
Until the world reduces emissions down to net-zero, the planet will continue to warm.
Global warming didn't take the year off in 2020: The planet was near record hot again last year, climate groups announced Thursday.
While NASA said that 2020 essentially tied with 2016 as the Earth's warmest year on record, other groups, such as the National Oceanic and Atmospheric Administration, said it was the second-warmest year.
"Whether one year is a record or not is not really that important – the important things are long-term trends," said NASA climate scientist Gavin Schmidt. "The last seven years have been the warmest seven years on record, typifying the ongoing and dramatic warming trend," he said.
Also, according to NOAA, 2020 was the 44th consecutive year (since 1977) with global temperatures above the 20th-century average.
NOAA and NASA measurements go back to 1880.
"With these trends, and as the human impact on the climate increases, we have to expect that records will continue to be broken," Schmidt, who is director of NASA's Goddard Institute for Space Studies, said.
The burning of fossil fuels such as oil, natural gas and coal releases greenhouse gases such as carbon dioxide and methane into the Earth's atmosphere, causing the globe to warm to levels that cannot be explained by natural causes.
"We're in a position where we're pushing the climate system out of the bounds that it's been in for tens of thousands of years, if not millions of years," Schmidt said.
And although carbon emissions were down in 2020 due to the global COVID-19 pandemic, they continue to accumulate in the atmosphere. The amount of warming the world experiences is based on our total emissions since pre-industrial times, rather than our emissions in 2020, according to Zeke Hausfather, a climate scientist and director of climate and energy at the Breakthrough Institute in California.
In fact, surprisingly, the pandemic may have added ever so slightly to last year's warming, as people were driving less. This reduced the short-term aerosol pollution that acts as a cooling agent by reflecting heat.
More:2020 was an extreme year for Earth's temperatures. But was it the hottest on record? It depends.
"What matters for the climate is not the leaderboard of individual years," Hausfather tweeted Thursday. "Rather, it is the long-term upward trend in global temperatures driven by human emissions of greenhouse gases. Until the world reduces emissions down to net-zero, the planet will continue to warm."
The previous record warm year, 2016, received a significant boost from a strong El Niño. The lack of a similar assist from El Niño this year is evidence that the background climate continues to warm due to greenhouse gases, Schmidt said. La Niña, a natural cooling of Pacific Ocean water that was present toward the end of 2020, tends to lower the global temperature, while El Niño does the opposite.
"It is rather remarkable that a La Niña year could match the warmth of one of the strongest El Niños on record just a few years ago – illustrating the powerful impact that human greenhouse gas emissions are having on global temperatures," Hausfather wrote on the Carbon Brief website.
Last year's exceptional heat "is yet another stark reminder of the relentless pace of climate change, which is destroying lives and livelihoods across our planet," United Nations Secretary-General António Guterres said in a statement.
World Meteorological Organization Secretary-General Petteri Taalas, in a statement in December, said that "2020 has, unfortunately, been yet another extraordinary year for our climate. We saw new extreme temperatures on land, sea and especially in the Arctic."
"Wildfires consumed vast areas in Australia, Siberia, the U.S. West Coast and South America, sending plumes of smoke circumnavigating the globe," he said. "We saw a record number of hurricanes in the Atlantic, including unprecedented back-to-back Category 4 hurricanes in Central America in November. Flooding in parts of Africa and Southeast Asia led to massive population displacement and undermined food security for millions," Taalas added.
In the U.S., we smashed the record for the number of weather disasters that cost at least $1 billion with 22 of them in 2020, including hurricanes, wildfires, tornadoes and a Midwest derecho.
Contributing: The Associated Press
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As a Maple Grove and Osseo Auto Repair company, Accurate Auto & Tire Services has been conveniently providing quality car care in Osseo, Minnesota to surrounding areas since 1998. Jim Cox the owner has been in the vehicle service, repair and fleet maintenance field since 1967 when he was 12 years old. Prior to Accurate Auto Jim worked with FedEx in fleet maintenance, City of Brooklyn Center fleet maintenance, Taystee Bread fleet maintenance and retail service & repair… "We know how to maintain a safe, reliable and cost effective vehicle".
Accurate Auto & Tire Services is a ASE Blue Seal Certified auto repair center. We are able to provide the benefits of an established national entity with warrantied repair being a certified NAPA AutoCare center while maintaining the personal touch of a family owned business. We understand that your vehicle is a major investment, and that is why we care for each customer's vehicle as if it were our own. Our staff is trained to listen and find out what the customer expectations are, then deliver on them.
Please come by and visit our clean and professional shop in Osseo, Minnesota and meet your autocare professionals.
First Time Visitor to Accurate Auto & Tire Services? Save $10 on any service! Please call for an appointment. Not valid with any other offer.
All senior citizens ages 60 and older will receive 2% off all service and repair. Mention you saw this on our website when you come into our neighborhood location!


text:
People with disabilities now have police backing in protection of rights
By Rosemary Ogbonnaya
National Commission for Persons With Disabilities and the Nigeria Police have formed an alliance that will see to the compliance and enforcement of the 2018 Act prohibiting the discrimination of Persons With disabilities.
Speaking at the launch of the special desk for Persons with disabilities held at the Police force headquarters, the Executive Secretary National Commission for Persons With Disabilities, Mr. James David Lalu announced that Persons with disabilities now have the full support of men and Officers of the Nigeria Police in the protection of their rights and dignity.
While expressing gratitude to the Inspector General of Police Mr Alkali Usman Bab…
[1:52 AM, 1/11/2022] My boss: Ortom felicitates with Tambuwal at 56
Benue State Governor, Samuel Ortom has felicitated with his Sokoto State counterpart, Aminu Waziri Tambuwal on his 56th birthday.
Governor Ortom in a goodwill message to Tambuwal described him as a diligent, focussed and a result-oriented political leader.
The Governor said Tambuwal has demonstrated immense capacity for leadership both as the Speaker of the House of Representatives and as Governor of Sokoto State.
Ortom also noted that as Chairman of the Peoples Democratic Party (PDP) Governors Forum, "Tambuwal has brought togetherness, loyalty and healthy competition between and amongst PDP governors and the party in general."
He noted that Tambuwal is a forefront political leader who has brought his immense political sagacity, panache, dexterity and vibrancy into the Nigerian political space.
He said Tambuwal is one of the political leaders who has unshakable believe in the sanctity of the unity of Nigeria, stressing that "Tambuwal remains a detribalised Nigerian. His commitment to the reinvigoration of the PDP and the welfare of the citizens are worthy of commendation.
"I commend his efforts and urge him to uphold these rear attributes that has brought him this far in his political career. I wish him long life, wisdom, peace and good health in the years ahead."
While reiterating his confidence in the Nigeria Police, he also said that the desk offices will serve as quick response units which will handle any form of discrimination or abuse against PWDs in any part of the country.
In her keynote address, the Hon. Minister, Federal Ministry of Humanitarian Affairs, Disaster Management and Social Development, Hajia Sadia Umar Farouq who was represented by the Permanent Secretary of the Ministry Dr. Nura Alkali reiterated the Ministry's commitment to the welfare of Persons With Disabilities.
She used the platform to urge the Nigeria Police to inculcate the disability curriculum into the police Institute scheme so as to have inclusivity and visibility of PWDs in societal affairs.
Speaking further, Hajia Farouq mentioned that the 2018 Act prohibiting the discrimination of Persons With Disabilities will be "mere statements if not accompanied with enforcement"
The Inspector General of Police, Usman Alkali Baba in his speech, reassured Persons with Disabilities of the NPF's commitment to protecting not just the lives and properties of persons with disabilities but, giving maximum cover to them against social abuse.
He further said that there is an urgent need to de-stereotyping the mindset of the populace from neglect and dehumanizing attitude towards Persons With Disabilities.
Alkali underpinned that Disability Desk Offices will be operating as focal centers domiciled at the force headquarters in order to continue to bridge the gap between the police and PWDs.
The Chairman, Joint National Association of Persons With Disabilities,JONAPWD, Comrade Abubakar Aliu Usman also expressed absolute gratitude to the Nigeria Police for partnering with the National Commission for Persons With Disabilities to give the entire community of Persons with Disabilities the protection of their fundamental rights as provided by the 2018 Act.
He said the slogan" Police is your friend" has become a reality by the synergy established today.
The high point of the event was the unveiling of the Logo signifying partnership between the Nigeria Police and the National Commission for Persons With Disabilities.
Tags: backing, people, Police, protection, rights
UN begins talks in Sudan to resolve post-coup crisis
Ortom felicitates with Tambuwal at 56


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I strongly believe "first impression is the best impression" so will try my [login to view URL] me i can do my best for you in specified time period.


This [intensive historic resource] survey is just amazing!!!! You have done such a complete job. It is a wonderful piece of work. You have set it in context so well. Thanks for your wonderful work!!!
Thank you so very much for your historical recounting of the Van Benschoten Farm... It has given me a greater sense of pride and appreciation of your work and the Van Benschotens. I feel that I am truly part of this magnificent piece of history. I am convinced now more than ever that we definitely contracted the best person possible for this noble historical effort.
I just finished reading the nomination for National Historic Register and I am, well, moved. Your work on this is extraordinary. This is the first time that I have been exposed to a nomination and had no idea the level of detail involved. And, really, Neil, of course your expertise is significant and the attention to detail by backing up facts with documentation is expected, but your observations and interpretation of Samuel Harrison is fantastic.
I want to extend a very heartfelt thanks to you both for the tremendous job you did on the preparation of our Historic Preservation Plan. I am very proud of our Plan and a large part of its success was due to the extra effort that you both gave to this job. Many thanks again for the outstanding job.
The historic survey update conducted by Larson Fisher Associates for the Village of Cobleskill was grant project funded by the Preservation League of New York State highlighted in the organization's 2003 Annual Report. In describing the importance of the project, Cobleskill Historic District Review Commission member Debbie Yoder was quoted: "We use the survey at every meeting...it allows us to better educated the public about Cobleskill's wonderful buildings."
Neil Larson joined the nonprofit board of The Woodstock Guild of Craftsmen, Inc. in 1995. He was invited to join because of his deep love of the history of the Hudson Valley, his professional experience in architectural preservation and appreciation of the importance of the 1902 Byrdcliffe Art Colony...He serves on the Property Committee and Chairs the Collections Sub-Committee where he plays an important role in directing the conservation of our now growing collection of paper, paintings, furniture and historic objects...Thank goodness that Neil Larson came along when he did and brought the world of preservation and its standards to our attention. The Woodstock Guild is deeply indebted to Neil.
Dear Neil: Thank you for assisting us in one of the best New York Folk Lore Society forums we have had in years. We appreciate the kind donation of your time to educate scholars and enthusiasts from the region. I hope this is the beginning of a long collaboration in presenting the material culture of New York State.
As a property owner in Rockland County for 30 years, I certainly appreciated what you had to say in your article "GE, EPA & PCBs" [in the February 2003 issue of Planning Magazine]. Thank you !.
Whereas the Cider mill Friends in their attempt to save the mill have successfully secured listing of the Kimlin Cider Mill, on of the oldest cider mills in America, on the New York State and National Registers of Historic Places...does hereby honor and commend the volunteers of the Cider Mill Friends in support of their good work.
Thank you for the National Register nomination that you submitted for the Samuel Harrison House in Pittsfield. MHC staff has completed the preliminary review process. This is a fine nomination; it substantially enriches our understanding of the building type and its primary occupant, and could serve both as a model for future nominations and as a guide for future interpretations of the property itself.
Thank you for an outstanding presentation of the Town of Millville, specifically the National Register Main Street District. You have painted a graphic picture of the area; your written descriptions are clear and detailed and they do present a visual picture of the district. You have written another important chapter in our town's history. Thank you, Neil!
Several years ago, when the town of Mamakating wanted to learn how much of the D & H Canal still existed, their condition, location and who owned them, it hired Larson Fisher Associates. Neil and Jill produced an inventory of every land parcel the canal had once crossed, assessed its condition, determined the ownership, located it on today's maps and produced a wealth of additional information, maps and photographs at a very reasonable cost. This inventory gave us a blueprint of what to do to develop two miles of the towpath trail and started one of our major projects in motion. We would highly recommend their work to any community.


Blows my mind how many people I encounter that have never heard of The Jayhawks. Growing up I thought everyone knew the lyrics to "Sister Cry." I adopted them early upon raiding my older brothers CD tower in his room. One summer afternoon in the mid-90s I went snooping around and tucked in between the Black Crowe's "Amorica" and Green Day's "Dookie" – I pulled out The Jayhawks – Hollywood Town Hall. That was it. It fed me and lead me down the road of Wilco, Golden Smog and more.
The boys are back it with their latest release "Back Roads and Abandon Motels." Like the past, there is an evolution in their sound but maintains that little something that made me fall in love with them on that fateful afternoon in '95.
For those who are just getting into the boys from MPLS, think Crosby Still Nash meets Wilco or at times, The Beatles meet Steve Earle. Either way, let's take you on a little journey. Strap in and catch up.
Plus, let's be real. How many bands after 30 years could still get up and jam outdoors in the middle of a Minnesota winter? The Jayhawks. That. Is. Who.


text:
Is the Lisa Frank Hotel a Knockoff?
Is the Lisa Frank Hotel a Knockoff of This Apartment?
Designer Amina Mucciolo shared a very similar apartment—in the same development—two years ago.
By Hadley Keller Published: Jun 9, 2020
Studio Mucci
UPDATE, 6/9/2020: Nearly 8 months after designer Amina Mucciolo called out Lisa Frank for opening a hotel that looked suspiciously like her viral apartment, the company has issued a public response via an odd Instagram caption that uses the current buzz around the Black Lives Matter movement to criticize Mucciolo, a creative of color.
Below a graphic that (somewhat ironically) reads "Please support and love one another," the brand addressed Mucciolo's claims, which had resurfaced recently in light of increased conversations on racial inequity in design. The statement includes this paragraph:
"While all of the country was spending time reflecting, learning, listening, and taking action during Blackout Tuesday, we were disappointed to hear of an opportunistic individual taking that moment to focus attention on herself, for her own personal benefit, by repeating her false accusations that we have stolen artwork and designs from her. Over the past months, we have silently forgiven her need to deflect blame away from her own failures by perpetuating this false narrative; however, we owe it to our fans to speak out this one time to address these lies."
Mucciolo, for her part, stands by her claims, and has garnered a large group of supporters who have even donated to a GoFundMe on her behalf.
ORIGINAL STORY, 10/19/2019: Designer Amina Mucciolo will tell you she has a unique style. So would any of her friends who visited the creative's delightfully colorful Los Angeles apartment, any of her nearly 40,000 Instagram followers who have seen peeks of the space, and readers who enjoyed a tour of it on Apartment Therapy two years ago. Dubbed "Cloudland," the home is a funhouse of unexpected color pairings and pattern—a reflection of Mucciolo's personal style. "Like any space I live in, it has to look like and feel like me," she says. Which is why Mucciolo was surprised to open her phone one day and see the internet flooded with what looked like slightly off images of it, but was actually a Hotels.com-sponsored Lisa Frank suite.
Cloudland, Studio Mucci's Los Angeles apartment.
"People were tagging me and sending it to me, and I was just in shock," Mucciolo tells House Beautiful. Indeed, looking at the photos side by side is telling: Similar color-block cabinets, similar use of stuffed toys as decor, even eerily similar teal-colored coffeemaker. And it just so happens that the Lisa Frank Suite is in a building by the same developer, just across the street from Mucciolo's Los Angeles apartment—the Los Angeles apartment whose owner had been mysteriously trying to evict Mucciolo since August.
Mucciolo in her apartment.
"In August, they refused our rent," the designer says of the building, where she's been living since 2016. Refusing rent is illegal in Los Angeles, but the building is alleging Mucciolo hasn't paid and is therefore attempting to evict her. Mucciolo has been working with a lawyer to fight the eviction (they have a trial set for the end of this month), which she thought seemed out of the blue—until the Lisa Frank suite was unveiled.
"I believe I'm being evicted because of the Lisa Frank hotel," the designer said on Twitter, where many other creatives rushed to offer words of support. Hotels.com, for its part, replied that "this flat was curated with Lisa Frank's signature prints," and told House Beautiful that they didn't ask anyone to move or leave their homes as a result of the collaboration.
I believe I'm being evicted because of the Lisa Frank hotel. Our landlord refused payment & wanted us out before the launch. The LF hotel is in our development. It is VERY similar to our home that I designed in 2017. I think they were trying to get rid of the competition… me. pic.twitter.com/sKD48yurpk
— Amina Mucciolo (@StudioMucci) October 13, 2019
Of course, any designer knows that a style comes across in much more than a few specific prints, and to Mucciolo, the similarity is the example of the kind of risk independent designers take by sharing their work.
"I have an older brother who was always concerned about me sharing," she says. "We don't have an agent—it's just us sharing our work, so to share it like this, I did it because I thought that other people would benefit, so to have someone steal my work and profit from it when I'm financially struggling is such a devastating blow. It makes you feel so vulnerable."
As she tells me this, Mucciolo is understandably emotional—she pauses several times as she speaks through tears. One of the reasons the situation is so hurtful, she says, is because this isn't her first interaction with Lisa Frank.
A screen shot of an Instagram exchange between Mucciolo and Lisa Frank, provided by Mucciolo.
"In 2018, Lisa Frank—or whoever runs the Instagram account—started reaching out to me," the designer recalls. This was shortly after Cloudland had gone viral online, amping up Mucciolo's own internet presence. The Lisa Frank account sent her several DMs, commented on posts of her apartment, and even shared some of her work—in posts it has since deleted.
Despite its reputation for rainbows and smiling characters, Lisa Frank (both as a person and a company) has a less than gleaming reputation. In 2013, Jezebel ran a piece titled Inside the Rainbow Gulag, a scathing look at workplace practices at the company.
A Studio Mucci post shared on Lisa Frank's Facebook page.
"I hadn't heard any of that negative stuff," Mucciolo says. So, when she garnered the attention for the brand—whose bold color and pattern she, unsurprisingly, loved—"I was just so flattered. I thought it was so cool that you know, she likes my work. It was something that felt very validating. So to then have this..."
House Beautiful reached out to Lisa Frank through Instagram (the brand has no website) for comment, and received the following response: "Say our partners who managed the project hotels.com are handling all comments to press"—with an email address for Hotels.com.
A representative for Hotels.com issued the following statement: "Hotels.com and Lisa Frank collaborated to create a two-week, pop-up room using the famed artist's iconic look. No tenants were asked to move or leave their homes because of this temporary promotion."
To Mucciolo, though, the connections are just too odd to be coincidental—and the damage has already been done, both financially and emotionally. "It's just so frustrating to see something from your own imagination—maybe people don't recognize every detail—but to see things from your own mind interpreted and covered with corporate branding is just so sad," she says. "It's all surreal—I can't really believe this is happening."
Hadley Keller
Hadley Keller is House Beautiful's digital director. She oversees all digital content for the brand as well as working on the print magazine. She has covered covering design, interiors, and culture for 10 years in New York. She served as Associate Market Editor, Design Reporter, and News Editor for Architectural Digest and AD PRO before joining House Beautiful. Hadley is a staunch maximalist and vocal opponent of the Open Floor Plan.
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text:
HCVF
Hedvig Catharina von Fersen
Swedish noble
Mother: Hedvig Catharina Lillie
Father: Magnus Julius De la Gardie
Spouse: Axel von Fersen the Elder
Children: Axel von Fersen the YoungerHedvig Eleonora von FersenSophie PiperFabian Reinhold von Fersen
Not to be confused with Hedvig Catharina De la Gardie (1695–1745)
Hedvig Catharina von Fersen, née De la Gardie (Stockholm, 20 May 1732–Stockholm, 24 April 1800) was a Swedish noble. She was the daughter of the General and riksråd count Magnus Julius De la Gardie and the political salonist Hedvig Catharina Lilje, and sister of scientist Eva Ekeblad.
She married the riksråd count Axel von Fersen the Elder in 1752. Hedvig Catharina was the heir of Löfstad Castle, and her marriage thereby strengthened both the social and economic position of her spouse. She became the mother of Hedvig Eleonora von Fersen (1753–1792), Hans Axel von Fersen (1755–1810), Sophie von Fersen (1757–1816), and Fabian Reinhold von Fersen (1762–1818).
Through her marriage, she became the matriarch of one of the most powerful noble families in Sweden and a riksrådinna (spouse of a riksråd), securing her a position in the very elite of the Swedish aristocracy, and socialized in the circles of the royal court: Queen Louisa Ulrika once referred to her and Eva Ekeblad as her only true friends. Despite her position, however, there are no mentions of her ever having played a political role, despite this being fashionable for women of her status during the age of liberty. She is sometime mentioned in passing in contemporary diaries and letters, such as in 1774, when her relative count Claes Julius Ekeblad mention in his correspondence to Brita Horn, that her spouse, Axel von Fersen the Elder, had recently been succeeded as the lover of Eva Löwen by her son, Hans Axel von Fersen, and that his aunt Hedvig Catharina von Fersen "has been affected enough by this to cry - she, who never hesitate to separate a man from his wife."
In the 1760s, the Crown prince, (the future Gustav III of Sweden), was rumoured to be in love with her. In 1764, Prince Gustav had the habit of walking on the roof terrace on the Royal Palace because he wanted to make contact with her and see her when she showed herself on the roof of the Fersen Palace every day at four; he sent her flowers and asked for meetings in the park of Karlberg Palace. It is not likely that the relation went further than this; Hedvig's attitude to the attention was described as "somewhat amused, somewhat quite dismissive". After 1772, when her spouse was made riksråd (councillor of state), she was known at court as riksrådinna, the feminine equivalent, and thereby given a high status. She was described as a close friend of Gustav III during his first years as a monarch: she belonged to the intimate circle of debate-partners with whom he stayed up late at night discussing, and he found her intelligent and cultivated. During his cultural reforms in replacing the French language with Swedish in culture life, such as at the opera and theatre, she was one he asked for advice; at the première of the Swedish language opera Zaire (1774), she was the only one of the women at court to contradict him regarding his reform by saying that the Swedish word for "darling" was inferior to its French equivalent.
In 1774, Hedvig Catharina von Fersen was assigned by Gustav III with the task to meet the bride of his brother Prince Charles, Hedvig Elisabeth Charlotte of Holstein-Gottorp, on her arrival to Sweden. She left for Wismar in Swedish Pomerania in May with a retinue containing the four appointed ladies-in-waiting to the princess, two male courtiers and her own daughter, Sophie von Fersen. She hosted the formal receptions for local dignitaries, welcomed the princess in July and organised the festivities when Charlotte was married by proxy to Charles, represented by the Swedish governor count Carl Otto von Höpken, and the ceremony when Charlotte took leave of her court from Eutin and changed it for her new Swedish court. It was said that "she maneuvered herself through the difficulties with fine tact and sense". She finally escorted princess Charlotte to Sweden proper for her next wedding in Stockholm. Charlotte became acquainted with her daughter Sophie during this meeting, and remained closely attached to the Fersen family.
The relationship between Hedvig Catharina von Fersen and Gustav III was damaged during a court scandal in February 1777. von Fersen refused her daughter, Sophie von Fersen, to attend a rehearsal of the ballet Le carneval de Venice. This was an amateur performance consisting of members of the royal court which was staged by the king in honor of his mother. Because of a confusion of the time, Sophie von Fersen would have been forced to wait dressed in her evening gown in the royal antechamber in the company of professional ballet dancers, which her mother considered to be shameful of her noble status. This refusal created a scandal at court, and a formal reconciliation was not made until princess Charlotte managed to mediate in the affair.
The relationship of the von Fersen family and the royal house was to become strained with time, especially during the crisis of 1789, when her spouse became arrested as one of the leaders of the nobility in opposition to the king's Union and Security Act.
Hedvig had the church of Ljung rebuilt and donated a collection of historical coins to it, which are still preserved there, in 1796. She was buried in the same church. She was widowed in 1794, and died six years later.


text:
Q: Export emails to PST I have this code from How can I create an Outlook PST file using .Net? but this simply exports no data inside. Anyone can assist me?
Const BACKUP_PST_PATH As String = "C:\backup.pst"

Dim oFolder As Outlook.MAPIFolder = Nothing
Dim oMailbox As Outlook.MAPIFolder = Nothing

Dim app As New Outlook.Application()
Dim ns As Outlook.NameSpace = app.GetNamespace("MAPI")
Try
    //if the file doesn not exist, outlook will create it
    ns.AddStore(BACKUP_PST_PATH)
    oFolder = ns.Session.Folders.GetLast()
    oMailbox = ns.PickFolder()

    For Each f As Outlook.Folder In oMailbox.Folders
        If f.DefaultItemType <> Microsoft.Office.Interop.Outlook.OlItemType.olMailItem And f.FolderPath <> oFolder.FolderPath Then
            f.CopyTo(oFolder )
        End If
    Next

    ns.RemoveStore(oFolder)

Catch ex As Exception
    ns.RemoveStore(oFolder)
    IO.File.Delete(BACKUP_PST_PATH)
    Throw ex
End Try

redpajama_set_name: RedPajamaStackExchange


text:
Hamlet by William Shakespeare
Act I, Scenes 1–2 Summary and Analysis
Act II, Scenes 1–2 Summary and Analysis
Act III, Scenes 1–2 Summary and Analysis
Act IV, Scenes 1–4 Summary and Analysis
Act V, Scene 1 Summary and Analysis
The Ghost of King Hamlet
Rosencrantz and Guildenstern
Hamlet, Prince of Denmark
Framing Ophelia: Representation and the Pictorial Tradition
Grinning Death's-Head: Hamlet and the Vision of the Grotesque
Hamlet (Vol. 35)
Hamlet and A Matter Tender and Dangerous
Hamlet and the Scottish Succession
Hamlet's Ear
Mourning and Misogyny: Hamlet, The Revenger's Tragedy, and the Final Progress of Elizabeth I, 1600-1607
Nobler in the Mind: The Dialect in Hamlet
The 'Heart of My Mystery': Hamlet and Secrets
The First Quarto of Hamlet: Reforming Widow Gertred
The Last Mystery
What do Polonius's admonitions, beginning "And these few precepts," to Laertes and Ophelia in Act I, Scene iii, suggest about court life, and is it good advice?
Some of the most familiar quotations in the English language are found in Polonious's advice to Laertes and are considered good advice, among them, (1) "Neither a borrower nor a lender be" and (2) "To thine own self be true." He also advises his son (3) to be friendly but not overly so and (4) to listen more than speak.
As for Ophelia, she is harshly advised to "tender herself more dearly" when she confesses to her father Hamlet's affection (1.3.115). Polonius is afraid she will sleep with him, though Ophelia protests that "he has importuned me in an honorable fashion" (1.3.119-120).
As for what is says...
(The entire section contains 319 words.)
What advice do both Polonius and Laertes give to Ophelia in Hamlet, act 1, scene 3?
Is Polonius's advice to Laertes good in Act I, Scene iii?
What advice does Polonius give to Laertes in "Hamlet"?
In Hamlet, what advice does Polonius give Laertes?
Is the advice Polonius offers Laertes trustworthy? Polonius sometimes appears bumbling and...
zumba96 | Student
Towards Ophelia he basically tells her to be careful with Hamlet as nothing good will come out of it. It is not wise to continue meeting with him and he does not want his honor to be ruined. His daughter's honor as well, but firstly he does not want HIS honor to be ruined. As for Laertes, what he is trying to say becomes utterly confusing. Do this but not this. This but definitely not this. There are so many juxtaposing factors in this speech it is unsure what he wants him to fully do. But as Laertes goes to Paris he wants to keep him in check and give "good advice". The main 4 things he meant for Laertes was
1) don't borrow money but don't lend it either
2) Be true to yourself
3) Be friendly but don't be too friendly
4) Listen more then you speak
Why does Hamlet tell Ophelia to go "to a nunnery" and what does he give as his reason?
At the end of Act 3, Scene 3, why didn't Hamlet kill Claudius when he had the chance?
In act 1, scene 3, of Hamlet, what is Polonius's advice to Laertes?
Explain the significance of Hamlet's soliloquy in Act 2, scene 2, of William Shakespeare's...
How many soliloquies are there in Hamlet?
Hamlet Summary
Hamlet Themes
Hamlet Characters
Hamlet Analysis
Hamlet Annotated Text
Hamlet Quiz
Hamlet Lesson Plans


AT&T MOBILITY, LLC; CITY OF DALLAS, TEXAS; and ALAN JARVIS, Individually, Defendants.
Defendants AT&T Mobility, LLC, the City of Dallas, Texas, and Alan Jarvis move pursuant to Fed.R.Civ.P. 37(c)(1) to strike the late designation of expert witnesses by plaintiff Thomas Landell Davidson ("Davidson") and to prevent these witnesses from testifying in any hearing or at trial. Davidson has not responded to the motion. For the reasons that follow, the court grants the motion in part and denies it in part.
The scheduling order in this case required that the parties designate expert witnesses and otherwise comply with Rule 26(a)(2) by October 10, 2017. On December 19, 2017, two months after the deadline, Davidson filed his designation of expert witnesses and designation of potential witnesses. On January 1, 2018 Davidson filed his first amended designation of potential witnesses. Among these three documents, Davidson designates as experts eleven medical professionals and two employees of the law firm that represents him. According to the designations, these experts will testify "regarding the medical treatment of the Plaintiff" and "the reasonable and necessary attorneys' fees incurred by the Plaintiff, " respectively. P. Desig. of Expert Witnesses 1. Davidson did not move for leave or seek to modify the scheduling order before belatedly filing these expert designations.
[i]f a party fails to provide information or identify a witness as required by Rule 26(a) or (e), the party is not allowed to use that information or witness to supply evidence on a motion, at a hearing, or at a trial, unless the failure was substantially justified or is harmless.
Rule 37(c)(1). In evaluating whether a violation of Rule 26 is substantially justified or harmless, the court examines four factors: (1) the importance of the evidence; (2) the prejudice to the opposing party of including the evidence; (3) the possibility of curing such prejudice by granting a continuance; and (4) the explanation for the party's failure to disclose. Hoffman v. L & M Arts, 2013 WL 81578, at *1-2 (N.D. Tex. Jan. 8, 2013) (Fitzwater, J.). "Implicit in Rule 37(c)(1) is that the burden is on the party facing sanctions to prove harmlessness." Current v. Atochem N. Am., Inc., 2001 WL 36101282, at *2 (W.D. Tex. Sept. 18, 2001); see also Companion Prop. & Cas. Ins. Co. v. Opheim, 92 F.Supp.3d 539, 544 (N.D. Tex. 2015) (Fish, J.) ("Because [the party facing sanctions] failed to demonstrate that its failure to designate Bourneuf as an expert witness was either 'substantially justified or . . . harmless, ' . . . the court must exclude the relevant paragraphs of the declaration from evidence."); Red Dot Bldgs. v. Jacobs Tech., Inc., 2012 WL 2061904, at *3 (E.D. La. June 7, 2012) ("Exclusion of the evidence is mandatory and automatic unless the party demonstrates substantial justification or harmlessness.").
Defendants maintain that they will be prejudiced by the delay required to prepare for the late-designated expert witnesses, in addition to the increased legal costs. Because Davidson has not responded to the motion to strike, he has not demonstrated that his failure to comply with Rule 26(a) was substantially justified or harmless. Moreover, Davidson has made no other attempt to explain his late expert designations, either through seeking leave of court or otherwise. The court therefore grants the motion to strike as to all experts except the law firm witnesses who will testify concerning attorney's fees and nontaxable expenses.
Although Davidson has not responded to defendants' motion, the court declines to exclude his witnesses on attorney's fees and related nontaxable expenses, despite the failure to timely designate them.
This court has typically treated the designation of attorney's fee experts differently from other experts. In most instances, as in the present case, Rule 54(d) provides that attorney's fees are decided by the court on motion filed after the entry of judgment. Attorneys who represent parties against whom such fees are sought are not surprised by expert testimony because they can usually expect that opposing counsel will attempt to prove his attorney's fees and because they are themselves experts on the subject. Because the matter is handled by motion and usually decided on affidavits, the court can cure any prejudice that a party may face from a tardy designation by continuing submission of the attorney's fee issue if the party needs additional time to obtain its own expert.


Fill a windshield washer reservoir only with special liquid intended for a washer or clear water. It is dangerous to use the low-freezing cooling liquid as windscreen washer liquid. At hit of cooling liquid on a windshield visibility through glass will worsen that can lead to the road accident. Do not include a washer. previously without having warmed up a windshield. Do not fill in cold season a washer reservoir with simple water. It is dangerous to use washer liquid which freezes at a negative temperature of air in cold season. Liquid of a washer can freeze on a windshield and is sharp worsen review conditions. You can get into the accident.
Press the lever towards yourself to include a washer of a windshield (fig. 1.73). The washer will give liquid on a windshield while the lever keeps in the pressed situation.
If the control lever a screen wiper is in the provision of "OFF" (is switched off) or "INT" (a faltering operating mode) (option A) "/AUTO" (an automatic operating mode) (option B), then at inclusion of a washer the screen wiper will continuously work until the lever is not released.


You might have noticed my absence (or not 😁) for the past few days. It's because I haven't been feeling so good lately. I've been feeling lethargic and all I was able to do is lie down and hope that I'll get better. I blame it all on the unpredictable weather. Really. 😁 2 years in France and I still can't seem to adjust to the cold. I miss the tropic especially now that it's summer over in the Philippines and everyone I know seems to be enjoying the sun. I'm kinda homesick, I guess. On the bright side, I did manage to get a bit of reading done in between eating and sleeping and after a few days of being tied to the bed, I'm feeling so much better.
So, anyway, I'm back now for a wrap-up from last month. I've got to say, it looks like I got my mojo back. Not only when it comes to reading, (hey, I managed to squeeze in 8 books!) but also blogging-wise. Not so much blog post but still kinda regular. Slowly getting there. 😁 Anyhow, let's get to the monthly recap, yeah?
It was really hard to choose a favorite because I happened to read great books last month that I give most a 4 and above rating. In the end, I'll go with the clever yet dark The Camera Lies.
Me too not feeling great lately, all I do is just lie down and read at turtle speed. My reasons are different but feeling damn tired. Happy reading!
I have fallen behind on my Goodreads challenge as well because of a slump I was in in February I think I am currently 4 or 5 books behind schedule of reaching my goal of 100. Like you said though we still have plenty of time to get back on track.
Thank you! My slump lasted about two weeks. Once March 1st hit I was reading and it felt so good to be reading something.
Glad to see you back posting, sorry to hear that you are homesick though. So far I am doing well with my reading challenges, but I mainly set low ones because I don't want to put too much pressure on myself. I used to set mine a lot higher and it took the fun out of reading. I ended up speed reading everything and not really reading, if that makes sense?


text:
Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips
R. D Emmanuele Di Villa Bianca, R. Sorrentino, F. Roviezzo, C. Imbimbo, A. Palmieri, G. De Dominicis, F. Montorsi, G. Cirino, V. Mirone
IRCCS Ospedale San Raffaele
Apomorphine is used in the erectile dysfunction therapy and its action has been ascribed to the stimulation of central dopamine receptor. At the present stage, very little is known about the peripheral action of apomorphine on human corpus cavernosum (HCC). We have investigated the peripheral action of apomorphine and the role of dopamine receptors in HCC. We here demonstrate that both D1 and D2 receptors were expressed in the HCC, D1 receptors were two-fold more abundant than D2 and that both receptors were mainly localized on the smooth muscle cell component. Apomorphine in vitro exerted an anti-α1 adrenergic activity in human cavernosal strips since it prevented contraction induced by phenylephrine (PE), but not by U46619 or endothelin. Apomorphine elicited endothelium-independent and concentration-dependent relaxation of the strips contracted by PE, U46619 or endothelin. The EC50 values (μM) for apomorphine, in the presence and absence of endothelium, were 51.0 ± 16 and 16.0 ± 14, 120 ± 19 and 150 ± 18, 59.0 ± 15 and 140 ± 50 on PE-, U46619- or endothelin-induced contraction, respectively. Selective dopamine receptor agonist A-68930 (D1-like), but not quinpirole (D2-like), caused concentration-dependent relaxation of the cavernosal strips, which was partially prevented by endothelium removal or by treatment with an inhibitor of nitric oxide (NO) synthase. In conclusion, we show that (1) apomorphine has a peripheral relaxant direct effect as well as an antiadrenergic activity, (2) HCC possesses more D1-like (D1 and D5) than D2-like (D2, D3 and D4) receptors, (3) both D1- and D2-like receptors are mainly localized on smooth muscle cells and (4) the relaxant activity is most probably mediated by D1-like receptor partially through NO release from endothelium.
International Journal of Impotence Research
https://doi.org/10.1038/sj.ijir.3901293
Human corpus cavernosum
10.1038/sj.ijir.3901293
Dive into the research topics of 'Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips'. Together they form a unique fingerprint.
Apomorphine Medicine & Life Sciences 100%
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Medicine & Life Sciences 47%
Endothelins Medicine & Life Sciences 41%
Phenylephrine Medicine & Life Sciences 39%
Adrenergic Antagonists Medicine & Life Sciences 29%
Dopamine Receptors Medicine & Life Sciences 27%
Human Activities Medicine & Life Sciences 24%
Di Villa Bianca, R. D. E., Sorrentino, R., Roviezzo, F., Imbimbo, C., Palmieri, A., De Dominicis, G., Montorsi, F., Cirino, G., & Mirone, V. (2005). Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips. International Journal of Impotence Research, 17(2), 127-133. https://doi.org/10.1038/sj.ijir.3901293
Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips. / Di Villa Bianca, R. D Emmanuele; Sorrentino, R.; Roviezzo, F. et al.
In: International Journal of Impotence Research, Vol. 17, No. 2, 03.2005, p. 127-133.
Di Villa Bianca, RDE, Sorrentino, R, Roviezzo, F, Imbimbo, C, Palmieri, A, De Dominicis, G, Montorsi, F, Cirino, G & Mirone, V 2005, 'Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips', International Journal of Impotence Research, vol. 17, no. 2, pp. 127-133. https://doi.org/10.1038/sj.ijir.3901293
Di Villa Bianca RDE, Sorrentino R, Roviezzo F, Imbimbo C, Palmieri A, De Dominicis G et al. Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips. International Journal of Impotence Research. 2005 Mar;17(2):127-133. doi: 10.1038/sj.ijir.3901293
Di Villa Bianca, R. D Emmanuele ; Sorrentino, R. ; Roviezzo, F. et al. / Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips. In: International Journal of Impotence Research. 2005 ; Vol. 17, No. 2. pp. 127-133.
@article{8056f1e83ffa4c78ab86d4e3482a5f6e,
title = "Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips",
abstract = "Apomorphine is used in the erectile dysfunction therapy and its action has been ascribed to the stimulation of central dopamine receptor. At the present stage, very little is known about the peripheral action of apomorphine on human corpus cavernosum (HCC). We have investigated the peripheral action of apomorphine and the role of dopamine receptors in HCC. We here demonstrate that both D1 and D2 receptors were expressed in the HCC, D1 receptors were two-fold more abundant than D2 and that both receptors were mainly localized on the smooth muscle cell component. Apomorphine in vitro exerted an anti-α1 adrenergic activity in human cavernosal strips since it prevented contraction induced by phenylephrine (PE), but not by U46619 or endothelin. Apomorphine elicited endothelium-independent and concentration-dependent relaxation of the strips contracted by PE, U46619 or endothelin. The EC50 values (μM) for apomorphine, in the presence and absence of endothelium, were 51.0 ± 16 and 16.0 ± 14, 120 ± 19 and 150 ± 18, 59.0 ± 15 and 140 ± 50 on PE-, U46619- or endothelin-induced contraction, respectively. Selective dopamine receptor agonist A-68930 (D1-like), but not quinpirole (D2-like), caused concentration-dependent relaxation of the cavernosal strips, which was partially prevented by endothelium removal or by treatment with an inhibitor of nitric oxide (NO) synthase. In conclusion, we show that (1) apomorphine has a peripheral relaxant direct effect as well as an antiadrenergic activity, (2) HCC possesses more D1-like (D1 and D5) than D2-like (D2, D3 and D4) receptors, (3) both D1- and D2-like receptors are mainly localized on smooth muscle cells and (4) the relaxant activity is most probably mediated by D1-like receptor partially through NO release from endothelium.",
keywords = "Apomorphine, cAMP, Dopamine receptors, Human corpus cavernosum",
author = "{Di Villa Bianca}, {R. D Emmanuele} and R. Sorrentino and F. Roviezzo and C. Imbimbo and A. Palmieri and {De Dominicis}, G. and F. Montorsi and G. Cirino and V. Mirone",
doi = "10.1038/sj.ijir.3901293",
journal = "International Journal of Impotence Research",
T1 - Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips
AU - Di Villa Bianca, R. D Emmanuele
AU - Sorrentino, R.
AU - Roviezzo, F.
AU - Imbimbo, C.
AU - Palmieri, A.
AU - De Dominicis, G.
AU - Montorsi, F.
AU - Cirino, G.
AU - Mirone, V.
N2 - Apomorphine is used in the erectile dysfunction therapy and its action has been ascribed to the stimulation of central dopamine receptor. At the present stage, very little is known about the peripheral action of apomorphine on human corpus cavernosum (HCC). We have investigated the peripheral action of apomorphine and the role of dopamine receptors in HCC. We here demonstrate that both D1 and D2 receptors were expressed in the HCC, D1 receptors were two-fold more abundant than D2 and that both receptors were mainly localized on the smooth muscle cell component. Apomorphine in vitro exerted an anti-α1 adrenergic activity in human cavernosal strips since it prevented contraction induced by phenylephrine (PE), but not by U46619 or endothelin. Apomorphine elicited endothelium-independent and concentration-dependent relaxation of the strips contracted by PE, U46619 or endothelin. The EC50 values (μM) for apomorphine, in the presence and absence of endothelium, were 51.0 ± 16 and 16.0 ± 14, 120 ± 19 and 150 ± 18, 59.0 ± 15 and 140 ± 50 on PE-, U46619- or endothelin-induced contraction, respectively. Selective dopamine receptor agonist A-68930 (D1-like), but not quinpirole (D2-like), caused concentration-dependent relaxation of the cavernosal strips, which was partially prevented by endothelium removal or by treatment with an inhibitor of nitric oxide (NO) synthase. In conclusion, we show that (1) apomorphine has a peripheral relaxant direct effect as well as an antiadrenergic activity, (2) HCC possesses more D1-like (D1 and D5) than D2-like (D2, D3 and D4) receptors, (3) both D1- and D2-like receptors are mainly localized on smooth muscle cells and (4) the relaxant activity is most probably mediated by D1-like receptor partially through NO release from endothelium.
AB - Apomorphine is used in the erectile dysfunction therapy and its action has been ascribed to the stimulation of central dopamine receptor. At the present stage, very little is known about the peripheral action of apomorphine on human corpus cavernosum (HCC). We have investigated the peripheral action of apomorphine and the role of dopamine receptors in HCC. We here demonstrate that both D1 and D2 receptors were expressed in the HCC, D1 receptors were two-fold more abundant than D2 and that both receptors were mainly localized on the smooth muscle cell component. Apomorphine in vitro exerted an anti-α1 adrenergic activity in human cavernosal strips since it prevented contraction induced by phenylephrine (PE), but not by U46619 or endothelin. Apomorphine elicited endothelium-independent and concentration-dependent relaxation of the strips contracted by PE, U46619 or endothelin. The EC50 values (μM) for apomorphine, in the presence and absence of endothelium, were 51.0 ± 16 and 16.0 ± 14, 120 ± 19 and 150 ± 18, 59.0 ± 15 and 140 ± 50 on PE-, U46619- or endothelin-induced contraction, respectively. Selective dopamine receptor agonist A-68930 (D1-like), but not quinpirole (D2-like), caused concentration-dependent relaxation of the cavernosal strips, which was partially prevented by endothelium removal or by treatment with an inhibitor of nitric oxide (NO) synthase. In conclusion, we show that (1) apomorphine has a peripheral relaxant direct effect as well as an antiadrenergic activity, (2) HCC possesses more D1-like (D1 and D5) than D2-like (D2, D3 and D4) receptors, (3) both D1- and D2-like receptors are mainly localized on smooth muscle cells and (4) the relaxant activity is most probably mediated by D1-like receptor partially through NO release from endothelium.
KW - Apomorphine
KW - cAMP
KW - Dopamine receptors
KW - Human corpus cavernosum
U2 - 10.1038/sj.ijir.3901293
DO - 10.1038/sj.ijir.3901293
JO - International Journal of Impotence Research
JF - International Journal of Impotence Research


text:
Q: How to add more than one relationship in the Core Data? I am trying to add song into multiple playlist. I am using this code below, but when I use this function it keeps overriding the old relationship with other playlist. Example, I add SongA to playlist(A) and I call this function again and add SongA to playlist(B), the SongA in playlist(A) is gone.
open class func addToRelationships(_ identifier : String, playlistName : String){
    print("Adding Relationship to the Song and the Playlist")
    let selectedPlaylist = getPlaylist(playlistName)
    let selectedSong = getSong(identifier)
    //add song reference to songs relationship (in playlist entity)
    let playlist = selectedPlaylist.mutableSetValue(forKey: "songs")
    playlist.add(selectedSong)
    //add playlist reference to p laylists relationship (in song entity)
    let inPlaylists = selectedSong.mutableSetValue(forKey: "playlists")
    inPlaylists.add(selectedPlaylist)
    save()
}

I am currently using this for the Core Data.


So Fashionably Frugal: Eensy Weensy Haul: The Tote Bag I chose!
Eensy Weensy Haul: The Tote Bag I chose!
I said I'd tell you what bag I'd choose this year for college! It took me a while because I ended up hating my first pick, which was the Feed for Target bag. I decided that I needed a tote bag because I tote so much art supplies around with me! Luckily, when I went recently to Target for school supplies I found the perfect bag!
Here's everything I bought that day. I call it an eensy weensy haul because, well...compared to hauls I've seen on YouTube, this is nothing! But I got some fun stuff that I think is worth sharing with you!!
1) Aztec Woven Tote (Target $24.99)- Looks a lot more expensive than it is in my opinion. Beautiful colors and a fake leather handle. It seems to be very sturdy and easy to clean, which is a plus for me!
2) Fabric Covered Thumbtacks (Target)- They are too cute for words! & I got the last one!
4) Heart Post-Its (Staples)- I have a Post-It addiction like no other. I absolutely couldn't resist this one!
5)Washi Tape- Striped (Target), Pink (Wal-Mart)- Another addiction of mine. I like to put them on my school notebooks. They are a great way to add a unique touch to your things!
6) Nutella To Go- I'm a health nut, and this definitely isn't super healthy. But I heard it's delicious and I wanted to give it a try! Why not, right?
7)Mead Notebook- Target- Really small, cute and flexible. Being an art student, I don't take much notes. It's all about drawing. So, notebooks are barely needed.
The Best Oversized Sweaters Under $60!
Back to College : School Bags For Under $55!


Now you can have it all: Lifestyle, luxury, location and limited tax liability. Without doubt Castillo Caribe is one of the finest beachfront estate homes in the world offering every luxury for modern day life with all the lifestyle options one would expect from the Cayman Islands. Although the Cayman Islands enjoy year round sunshine and a temperate climate, this benefit is eclipsed in most people's eyes by the Islands' offshore status.


Kim Ha-na no longer sleeps or eats and is haunted by the voice of her 17-year-old brother, calling frantically to tell her the ferry he was aboard with more than 300 classmates and staff from his high school on the outskirts of Seoul was sinking.
More than 50 people are now known to have died and 252, mostly children, an presumed dead in the upturned hull of the stricken vessel that capsized off the southwestern tip of the Korean Peninsula on Wednesday.
Since then, Kim and hundreds of other relatives have spent 24 hours a day waiting helplessly for news in makeshift accommodation at a gymnasium in the port city of Jindo, the centre of the rescue operation.
They live and grieve together, packed into the floor space on narrow, thin mattresses, taking to a communal microphone to vent their hopes and their anger at government officials over the seemingly slow pace of the rescue and patchy information.
Kim`s brother, Dong-hyup, was one of 339 pupils and teachers from Danwon High School on an annual outing to the subtropical island of Jeju, making up most of the 476 passengers and crew.
``He called me at 8 a.m., saying the ship is sinking. Then I lost him,`` Kim, a 22-year-old student, told Reuters.
The Sewol ferry took more than two hours to sink in calm waters on a well-travelled 400 km (300-mile) route from the mainland South Korean port of Incheon to Jeju, a journey of 13-and-a-half hours.
The gym has become a focal point for anger and fading hope.
It was also the scene of one more tragic death. Kang Min-gyu, 52, the Vice Principal of Danwon High School, went missing on Thursday and was later found hanged with his belt from a pine tree outside the gymnasium.
Kang left a heart-rending two-page suicide note that was partly released by police in which he said he could not live while the fate of 200 others was unknown.
Professional care is available on site, there is free Internet and medicines as well as shampoo and soap, but South Korean officials have struggled to cope with the overwhelming tragedy.
Officials took DNA swabs from relatives on Saturday, adding to the foreboding that what had been billed as a rescue mission has become an operation to recover and identify bodies.
``It is a group trauma, not just for parents here but for people across the country. It`s not going to be over in one or two months. It is leaving a big scar,`` said a 48-year-old member of a team of counsellors at the gym, surnamed Yoon.
She declined to give her full name. Many Koreans often do not wish to see their full names used in media commenting on sensitive issues.
There`s no escape from the tragedy. Endless TV news and footage from the rescue is played on four huge television screens that relay information to the hundreds grieving inside the gym.
When relatives obtained underwater footage of the rescue taking place in the murky, tidal waters around the Sewol after divers said they had seen bodies, coastguard officials were jeered by those watching.
President Park Geun-hye was heckled by some when she visited the site on Thursday, a rare occurrence in a hierarchical country where respect for authority still counts for a lot.
The microphone set up on a stage is now used more to give voice to frustration and anger than for expressing any hope, and channels the rising emotions of those waiting largely in fear.
``It will be a miracle if they are alive. I just want to hug my child`s body,`` a father said from the stage to applause from other waiting relatives.
At other times, they grab at the collars of the coastguards trying to explain that they are doing the best to find the missing.
Often they just weep, looking at pictures of lost sons or daughters on their cellphones.


When it comes to graphical options Rise of the Tomb Raider has plenty to mess around with, providing full AA options and a large variety of in-Game settings, offering not just Nvidia made but also AMD made graphical effects.
This game supports high resolutions and high refresh rates, which will definitely please us PC gamers and gives us enough options that anyone with modern hardware should be able to achieve a stable 60FPS with a dedicated GPU.
On the Nvidia side we have their HBAO+ Ambient occlusion option and on the AMD side we have PureHair. Being an Nvidia partnered title this game has not heavily advertised it's PureHair feature, but at it's core is the latest version of AMD's TressFX, delivering the realistic hair we love with a much lower performance impact.
The game's graphical options can be modified both inside and outside of the game, allowing you to change your game settings easily and with little fuss.
On the controls side of things this game supports full mouse and keyboard key rebinding, allowing PC gamers to modify their controls to their liking, which is always a great thing to see. This game also has full support for PC controllers, giving them that control option if they prefer it, though we were sadly not able to rebind the controllers preset controls.
Below we have the game settings that we used to play the game, moving from the games Low to Very high presets and then moving beyond the games highest presets to what we call the games Highest settings.
This leaves us with 6 different sets of graphical detail options to test. You can see the presets below and can see screenshots comparing these settings and benchmark data for these settings on the following pages. These graphical options will all be tested with no AA.
An interesting set of results, nice to know at 1440p my 980Ti will do really well! Hopefully itll scale really well in SLI!


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At the bottom right, notice the "Give" button has a new friend called "Log in." That's because we have a new system in place called Fellowship One. Through it, we can share contact information, find people with common interests, and a whole bunch of other stuff we haven't even figured out yet.
It's fully customizable– you'll only share information you want to share. And you can choose different privacy settings for different groups of people. For example, you might want to let people in your Everyday Group see your phone number and mailing address, but share only your email address with everyone else.
If you've filled out a Connect Card in our service, then we've entered your information already and signing up with be a breeze. You'll just need to change your privacy settings so that others can see whatever part of your profile you'd like to make public (by default, all your info is hidden). You can also update your profile and keep your info current so you don't miss any important church communications future.


Posted by Lboogie Nyg Williams on June 22, 2014. Brought to you by facebook.
Don't go there. Don't go there. Don't go there.
Posted by by Mike Q at Insider Pages on May 31, 2012. Brought to you by Insider Pages.
Posted on September 02, 2016. Brought to you by yellowise.


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Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies.
Emerging Risk Factors Collaboration None., Wormser D., Kaptoge S., Di Angelantonio E., Wood AM., Pennells L., Thompson A., Sarwar N., Kizer JR., Lawlor DA., Nordestgaard BG., Ridker P., Salomaa V., Stevens J., Woodward M., Sattar N., Collins R., Thompson SG., Whitlock G., Danesh J.
BACKGROUND: Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease. METHODS: We used individual records from 58 cohorts to calculate hazard ratios (HRs) per 1 SD higher baseline values (4.56 kg/m(2) higher BMI, 12.6 cm higher waist circumference, and 0.083 higher waist-to-hip ratio) and measures of risk discrimination and reclassification. Serial adiposity assessments were used to calculate regression dilution ratios. RESULTS: Individual records were available for 221,934 people in 17 countries (14,297 incident cardiovascular disease outcomes; 1.87 million person-years at risk). Serial adiposity assessments were made in up to 63,821 people (mean interval 5.7 years [SD 3.9]). In people with BMI of 20 kg/m(2) or higher, HRs for cardiovascular disease were 1.23 (95% CI 1.17-1.29) with BMI, 1.27 (1.20-1.33) with waist circumference, and 1.25 (1.19-1.31) with waist-to-hip ratio, after adjustment for age, sex, and smoking status. After further adjustment for baseline systolic blood pressure, history of diabetes, and total and HDL cholesterol, corresponding HRs were 1.07 (1.03-1.11) with BMI, 1.10 (1.05-1.14) with waist circumference, and 1.12 (1.08-1.15) with waist-to-hip ratio. Addition of information on BMI, waist circumference, or waist-to-hip ratio to a cardiovascular disease risk prediction model containing conventional risk factors did not importantly improve risk discrimination (C-index changes of -0.0001, -0.0001, and 0.0008, respectively), nor classification of participants to categories of predicted 10-year risk (net reclassification improvement -0.19%, -0.05%, and -0.05%, respectively). Findings were similar when adiposity measures were considered in combination. Reproducibility was greater for BMI (regression dilution ratio 0.95, 95% CI 0.93-0.97) than for waist circumference (0.86, 0.83-0.89) or waist-to-hip ratio (0.63, 0.57-0.70). INTERPRETATION: BMI, waist circumference, and waist-to-hip ratio, whether assessed singly or in combination, do not importantly improve cardiovascular disease risk prediction in people in developed countries when additional information is available for systolic blood pressure, history of diabetes, and lipids. FUNDING: British Heart Foundation and UK Medical Research Council.
Age Factors, Blood Pressure, Body Mass Index, Cardiovascular Diseases, Cholesterol, Cholesterol, HDL, Diabetes Mellitus, Female, Humans, Male, Middle Aged, Obesity, Abdominal, Proportional Hazards Models, Prospective Studies, Risk Assessment, Sex Factors, Smoking, Systole, Waist Circumference, Waist-Hip Ratio


Schools chief Sherri Ybarra has parted ways with her communications director two weeks after winning re-election.
Former communications director Allison Westfall's last day on the job was Tuesday, State Department of Education spokeswoman Kris Rodine confirmed late Wednesday morning.
Westfall had served as Ybarra's communications director since Feb. 13, 2017.
In a brief telephone interview Wednesday, Rodine did not offer any explanation for Westfall's abrupt departure, saying the SDE has a policy of not commenting on personnel matters.
Human Resources Director Suzy Nesbella informed the SDE staff of the staffing change Tuesday afternoon, according to a memo obtained by Idaho Education News.
Westfall also serves as chairwoman of the Nampa School Board.
Prior to joining Ybarra's SDE, Westfall served as director of community relations for the Nampa School District. Before that, from January 1998 to July 2006, Westfall was the public information officer for the SDE under former Superintendent of Public Instruction Marilyn Howard.
Westfall's departure represents another leadership shakeup at the SDE. Westfall had appeared near the top of Ybarra's organizational leadership chart.
On Aug. 17, Ybarra's former chief policy adviser Duncan Robb resigned.
In July, Ybarra's former Chief Deputy Superintendent Pete Koehler retired.
Peter McPherson succeeded Koehler. Robb's position remains unfilled, Rodine said Wednesday.
Ybarra had offered Robb's job to Will Goodman, but he accepted and then backed out before his planned Sept. 17 start date.
Westfall's departure means Ybarra has two key staff vacancies in the weeks leading up to the 2019 legislative session — the communications director and chief policy officer positions.
Ybarra has not said how she will handle the open communications director position. Rodine said any calls from education stakeholders will be forwarded to Scott Phillips next week.
Moving forward, Rodine said she still expects to serve as the primary contact for the news media.
On Nov. 6, Ybarra was re-elected to a four-year term.


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Rosie Pope, the creative force behind Rosie Pope Maternity and Rosie Pope Baby, shares her top ten tips for new parents!
While you're breastfeeding, there are nutrients your body needs to stay strong, energetic and keep that precious milk supply flowing.


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Water Desalination Investing
So Long, and Thanks for All the Water
Written by Keith Kohl
California is in a drought, and that makes no sense at all.
Why? Because it's a coastal state. It's right next to the biggest body of water on the planet: the Pacific Ocean.
In fact, there is more water than land on our planet. No one should be in a drought ever, right?
This is flawed logic, of course, because all of the water on this planet can't solve a drought crisis if that water is unusable.
And salty seawater is exactly that.
97% of the water on Earth is ocean water that we can't use for much of anything. To make it usable, the water has to be desalinated — cleared of all that salt.
But there's a bit of a dilemma...
Hold the Salt, Please
So far, desalination technology hasn't gotten very much attention because the U.S. — along with the rest of the world — has freshwater sources called aquifers.
These aquifers are deep underground and hold massive amounts of fresh water, which get filtered through layers of Earth, leaving it cleared of salt and sediment, ready to use.
And this would be all well and good, no need to look into desalination at all, except...
We're depleting those aquifers entirely too quickly:
Here you can see that the majority of major aquifers on Earth are in depletion phases, meaning they aren't being refilled as quickly as they need to be for sustainability.
We are running out of readily usable water.
Which means investment in desalination is going to have to pick up, and fast.
Last month I listed all the places the U.S. government will be investing in water. Roughly $280 million will be earmarked toward the water industry by 2017.
Of that, approximately $5.8 million will be going to the Bureau of Reclamation for desalination and purification research, $25 million will go to the Department of Energy to improve desalination technology, and another $20 million will be aimed right at desalination tech for energy applications.
That's nearly 20% of the water budget going into desalination alone.
And it's only getting more important...
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For the past few weeks, Luke Burgess, Christian DeHaemer, and I have been looking into ways to make you money on the increasingly troubling U.S. water crisis.
Desalination will be one of the biggest interests in the sector moving forward, and to get you started in that direction, check out Consolidated Water Co. Ltd. (NASDAQ: CWCO).
The company is already established in the water market as one of the biggest in the desalination game. It designs, develops, and operates both plants and water distribution systems.
And even with all that, it's still pretty small.
The company has 20 water plants that produce 26 million gallons of clean water per day. These plants are located in the Cayman Islands, the Bahamas, the British Virgin Islands, Belize, and Bali, Indonesia.
All places with clear access to ocean water just waiting to be freshened up.
Better yet, CWCO is entering the market in North America, specifically in northern Mexico and southern California, where the drought has hit the hardest.
Already the company is taking part in building a plant in Rosarito, Mexico, which will process 100 million gallons of water per day. It's set to be in production in 2017.
And although this could be a great small-cap opportunity to dig into before the market catches onto the water crisis that's developing worldwide, it's certainly not the only opportunity out there... not by a long shot.
Truth is, there's another hidden gem out there that's trading at a nice discount. More importantly, I want you to see how lucrative these water investments are firsthand, which is why I'm bundling up all of my research for you into a single investment report that will be in your hands soon.
Meanwhile, we'll dive even deeper into the ongoing water crisis over the coming weeks.
Keith Kohl
@KeithKohl1 on Twitter
A true insider in the energy markets, Keith is one of few financial reporters to have visited the Alberta oil sands. His research has helped thousands of investors capitalize from the rapidly changing face of energy. Keith connects with hundreds of thousands of readers as the Managing Editor of Energy & Capital as well as Investment Director of Angel Publishing's Energy Investor. For years, Keith has been providing in-depth coverage of the Bakken, the Haynesville Shale, and the Marcellus natural gas formations — all ahead of the mainstream media. For more on Keith, go to his editor's page.
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Energy and Capital editor Keith Kohl takes a closer look at the lithium revolution and why it could be the deathblow for oil.
Clean Water Supply Crisis
Energy and Capital editor Luke Burgess takes a look at the massive capital investment that will be needed to avoid a full-blown global water crisis.
Water Technology Investments
Energy and Capital editor Luke Burgess explores water technology investments and takes a look at one water stock he thinks has an interesting edge on the market.
Water Engineering and Consulting Stocks
Energy and Capital editor Luke Burgess offers readers a new water infrastructure play that could be well positioned to take advantage of $5 billion in Canadian government spending over the next two years.
Hydrogen Fuel Cells: The Downfall of Tesla?
Lithium has been the front-runner in the battery technology market for years, but that is all coming to an end. Elon Musk is against them, but Jeff Bezos is investing heavily in them. Hydrogen Fuel Cells will turn the battery market upside down and we've discovered the tiny company that is going to make it happen.
To learn everything about the battle set to shakeup the battery market and receive more insights from the minds at Energy & Capital, simply enter your e-mail address below. Forward-thinking investors believe this oppotunity will be one for the history books. See why today!
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Spine Fusion- This is a surgery that is performed to associate together individual vertebrae within the spine. When the vertebrae have a problem, the doctor may advise this procedure to eradicate the movement that exists within that area of the spine.
Lumbar disc replacement- This procedure is considered by doctors as unsafe compared to cervical disc replacement surgery. This is a new treatment option for some types of low back pain.
Lumbar discectomy- A discectomy is a procedure that involves the removal of a herniated disc from the spinal canal that causes the nerve pressure. A certain fragment of the normal spinal disc is expected to be dislodged when a disc herniation exists.
Foramenotomy- This is performed to relieve nerve pressure by pinching the nerve with more than just herniated disc. This procedure removes a part of the bone and some tissues that compress the nerve as it gets out from the spinal column.
Laminectomy- This is performed to relieve spinal cord pressure. This is usually used to treat conditions like spondylolisthesis and spinal stenosis.
Complications of spine surgery are always a risk and this must be considered carefully before deciding to have a surgical procedure.
Risks of Local Anesthetics- There are a lot of spine surgeries that are done under local anesthetic. This involves performing the whole procedure amid consciousness of the patient. Local anesthetic enables surgeries to be performed with less risk of paralysis.
Risks of General Anesthetic- General anesthetic involves the performance of a surgical procedure while the patient is unconscious. There a few patients who are allergic to some anesthetics. In rare cases, a patient can go into anaphylactic shock or even die. It is likely for general anesthetic to cause lung problems. It may lead to pulmonary infections and even pneumonia. This anesthetic increases heart attack risks as well as embolism and stroke.
Infections/Complications of Spine Surgery– Any surgical procedure carries a risk. Some infections might occur in the skin or in some deeper level of the wounds created during the surgery. A procedure that utilizes bone grafts out of a cadaver to reinforce a fusion is very prone to infections. When the spinal canal is infected, the patient will become sick or even die.
Spinal Fluid Leaks-There is a possibility of a dural tear in any procedures done within the spine. A leak will occur when there is a membrane puncture or rupture that covers the spinal cord. Though most leaks of spinal fluid can be corrected, those that are not corrected need an additional corrective surgery.
Nerve Damage-Nerve damage may cause a decreased sensation and body movement which may affect the functioning of the heart and lungs as well.
Paralysis-This is a major spine surgery risk. This may happen when a spinal cord injury is infected.
A spinal instability spine fusion is a predictable procedure. But, a multi-level lumbar degenerative disc disease fusion surgery may not be successful in alleviating pain after surgery.
A lumbar disc herniation discectomy that causes leg pain is also predictable. However, a lumbar disc herniation discectomy that causes lower back pain may not be successful.
This makes it important to stick to highly successful operations to ensure preoperative identification of an anatomic lesion that is to be corrected during the surgery.
Furthermore, failed spine surgery can be treated by a combination of selective endoscopic discectomy, laser disc decompression, intradiscal infiltration, differential provocative discography and intraforaminal steroids infiltration.
Next, visit the Spine Surgery Center of Excellence, a site devoted entirely to spine surgery and spine treatments.


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Hodgkin's lymphoma (Hodgkin's disease)
Sectionsfor Hodgkin's lymphoma (Hodgkin's disease)
Find a doctor whose last name begins with the letter I I
active Find a doctor whose last name begins with the letter T T
Last Name Initial: T
Ayalew Tefferi, M.D.
Myeloproliferative disorders, Chronic myelogenous leukemia, Chronic lymphocytic leukemia
Carrie A. Thompson, M.D.
Cancer survivorship program, Hodgkin lymphoma, Non-Hodgkin's lymphoma
Han W. Tun, M.D.
Bone marrow transplant, Lymphoma, Chronic lymphocytic leukemia
Mayo Clinic is an international leader in Hodgkin's lymphoma research. The Hematologic Malignancies Program conducts research related to Hodgkin's lymphoma and other blood and bone marrow cancers.
Developing and doing clinical trials for more-effective and less-toxic treatments for all forms of lymphoma
Studying quality of life in people with lymphoma
Studying who is more likely to have a relapse of lymphoma and why
Mayo Clinic Cancer Center is one of a handful of U.S. facilities that received a National Cancer Institute Specialized Program of Research Excellence (SPORE) grant for lymphoma research.
See a list of publications by Mayo Clinic authors on Hodgkin's lymphoma on PubMed, a service of the National Library of Medicine.
Hodgkin's lymphoma (Hodgkin's disease) care at Mayo Clinic
Hodgkin's vs. non-Hodgkin's lymphoma: What's the difference?
Bone marrow biopsy
Mayo Clinic Cancer Center


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Suspect arrested in Bellmawr for sexual assault
Matt Flowers
@CP_MFlowers
BELLMAWR – A Missouri man is facing charges for allegedly kidnapping and sexually assaulting his estranged girlfriend, authorities said Wednesday.
Jose C. Amaya-Vasquez, 30, of Kansas City, Missouri, kidnapped the 27-year-old mother of his child at knifepoint in Kansas City Saturday, according to the Camden County Prosecutor's Office.
He is also accused of sexually assaulting the victim at a vacant house in Missouri, a motel in Ohio and a motel in Bellmawr. Their 2-year-old daughter was present with them during the alleged crimes, authorities said.
Amaya-Vasquez was arrested in Bellmawr early Tuesday morning after detectives in Kansas City received cellphone evidence that aided them in determining the victim was at the Super 8 Motel on the 300 block of the South Black Horse Pike and alerted Bellmawr Police.
It is believed he had been passing through New Jersey with the victim and their child on the way to New York City, authorities said.
When Bellmawr Police responded to the motel, the victim opened the door and officers learned Amaya-Vasquez had fled through a tile ceiling, authorities said. Police observed the suspect outside and chased him into a wooded area. The suspect managed to climb a tree before he was found by police and taken into custody.
Amaya-Vasquez is being held at the Camden County Jail in lieu of $400,000 bail.


Mounted in an 18k white gold low square setting are eight lovely marquise emeralds surrounding a black onyx quatrefoil with a gorgeous bezel set diamond positioned in the center. Radiant white diamonds outline the edges of the ring truly enhancing the contrasting colors of the jet black onyx and the fresh green emeralds. This ring is a size 6.5 with 0.50 carats in diamond weight (VS1, I/J) and can be resized one or two sizes larger or smaller.