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Home›Viewpoint›Britain Rolls Red Carpet for Butcher of Yemen
Britain Rolls Red Carpet for Butcher of Yemen
Saudi Arabia's new crown prince Mohammed bin Salman will arrive in London on 7th of March for a three-day state visit during which he will meet with Prime Minister Theresa May, government officials and the royal family.
His full schedule has not been made public, but the prince is expected to join the Queen for dinner at Windsor Castle, before heading to No. 10 for a meeting with the PM.
The talks are aimed at strengthening defence, security and economic ties between the UK and Saudi Arabia, but "given how little we know about him and how important our relations with Saudi Arabia are held to be, it is fair to say that breaths are being held on both sides", the Times reports.
Demonstrations are set to take place outside Downing Street, with campaigners calling on May to challenge Prince Mohammed on human rights abuses and to suspend arms sales to Saudi Arabia.
Saudi Arabia and the UK will sign a series of agreements when the kingdom's crown prince Mohammed bin Salman visits London this week, in deals that diplomats said could be worth more than $100bn.
Among several other important roles, the 32-year-old is the country's defence minister. He is widely understood to be the driving force behind the Kingdom's forays into Yemen; where it backs the exiled government over the Iranian-supported Houthi rebels.
The humanitarian crisis in Yemen is a place where eight million people are on the brink of famine. The situation is now so dire it is being referred to as "Saudi's Vietnam".
A cholera outbreak that has already affected 900,000 is expected to flare up again, as the lack of fuel shuts off water and sewage systems. Twenty million people, more than two-thirds of the population, are in urgent need of humanitarian supplies.
British sales of military equipment to Saudi Arabia topped £1.1bn in the first half 2017, with government data showing a spike in sales since the spring.
The statistics from the Department for International Trade (DIT) show the UK sold £836m of arms and military hardware to Saudi Arabia between April and June 2017; up from £280m between January and March.
Saudi Arabia – which the UK PM Theresa May is currently visiting as one of her first trips after triggering the formal Brexit process in March – has purchased arms including air-to-air missiles, aircraft components and sniper rifles. The sales also include anti-riot gear, ballistic shields and body armour.
Britain has directly aided Saudi Arabia to murder people in Yemen. British made bombs and weapons have destroyed a country that was already one of the poorest in the world.
Blood stained hands are nothing new for Britain. However, the audacity of a state visit for one of the architects, such as bin Salman, is truly colonial arrogance.
Arms deals will be refreshed. Discussions on more trade deals post-Brexit will take place as well as more fine wining and dining. The Saud family has a dark relationship with Britain and it is not likely to be affected by the deaths of children in Yemen. It has never affected these relationships in the past- in fact, it only strengthens them.
It is a damning indictment, that the Saudi Kingdom with the British government, have inflicted terrible pain on the Muslims of Yemen.
Treachery is the heritage of the Saud family and each generation is raised upon it, right from when Ibn Saud was handed Makkah and Madinah by British colonial forces.
There is only one solution to Yemen and that is to challenge the colonial agenda of the West in that land via the reestablishment of the Khilafah Rashidah.
Only when the rulers of the Arab world are removed and the Ummah has a just leader that applies the rulings of Allah, will all people gain protection from the malicious design of brutal vultures.
"Indeed the Imam is a shield, behind whom you fight and you protect yourself with, so if he orders by taqwa and is just then he has reward for that, and if he orders by other than that then it is against himself." [Muslim]
TagsBritainColonialismMohammed bin SalmanSaudi ArabiaYemen
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Theresa May Visits Middle East with Vestiges of Empire
The colonialists celebrations in destroying the Khilafah are coming to an end


The SFW Newsletter is online now! Issue No. 1 shows a year full of highlights and events since the public presentation of the project as well as major milestones and upcoming events and activities.
Issue No. 2 is full of highlights, presentations and events as well and documents the progress of the model factories.
In this article, published in the IIC Journal of Innovation (March 2019 edition) you can read everything about it.


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Q: Automatic VBA Time Stamp when Copying and pasting Im new to VBA and was wondering if anyone can help me.
i have created this code which automatically adds a timestamp to a specific row when a cell is edited. However, if i want to paste in a load of data into the sheet, only the first row gets the timestamp, instead of every row.
can anyone help me?
thank you
Below is the current code used;
Private Sub Worksheet_Change(ByVal Target As Range)

Dim MyTableRange As Range
Dim myUpdatedRange As Range

Set MyTableRange = Range("A2:J150")

If Intersect(Target, MyTableRange) Is Nothing Then Exit Sub

Set myUpdatedRange = Range("K" & Target.Row)

myUpdatedRange.Value = Now()

End Sub

A: Target contains all cells that where modified. Simply loop over all cells in target will give you every single cell that was modified:
Dim cell As Range
For Each cell In Target
   ...
Next

As you want to put only one timestamp per row, you can limit the loop to all cells of the first column of Target:
Dim cell As Range
For Each cell In Target.Columns(1).Cells
    Cells(cell.Row, "K") = Now
    ' or, if you prefer:
    ' Range("K" & cell.Row) = Now
Next

A: A Worksheet Change: A Simple Time Stamp
Option Explicit

Private Sub Worksheet_Change(ByVal Target As Range)
    On Error GoTo ClearError

    Dim srg As Range: Set srg = Range("A2:J150")

    Dim irg As Range: Set irg = Intersect(srg, Target)
    If irg Is Nothing Then Exit Sub

    Dim drg As Range: Set drg = Intersect(irg.EntireRow, Columns("K"))

    Application.EnableEvents = False

    drg.Value = Now

SafeExit:
    If Not Application.EnableEvents Then Application.EnableEvents = True

    Exit Sub
ClearError:
    Debug.Print "Run-time error '" & Err.Number & "': " & Err.Description
    Resume SafeExit
End Sub

redpajama_set_name: RedPajamaStackExchange


text:
Contact: Bob Considine (609) 292-2994
Caryn Shinske (609) 984-1795
CAMDEN, TRENTON AND SECAUCUS JOIN DEP EFFORTS TO COMBAT ILLEGAL DUMPING
STATE'S "DON'T WASTE OUR OPEN SPACE" PROGRAM YIELDS 34 MORE ARRESTS; NEW MOBILE APP NOW AVAILABLE TO REPORT ILLEGAL DUMP SITES
(15/P67) TRENTON – Looking to build on the successes of the Department of Environmental Protection's crackdown on illegal dumping on state recreational properties, three New Jersey cities have partnered with the state's "Don't Waste Our Open Space" program to combat unlawful dumping in their own communities, DEP Commissioner Bob Martin announced today.
In addition to these partnerships with Camden, Trenton and Secaucus, DEP's "Don't Waste Our Open Space" initiative has yielded another 34 arrests for illegal dumping in state parks and wildlife management areas this year, totaling 62 enforcement actions since the program was launched in April, 2014.
A new mobile application has also been launched as part of the program, allowing visitors of state recreational areas to report dumping sites and the contents of the trash found at these locations so DEP can address the debris and launch an investigation.
"We hope getting more people to become aware of illegal dumping and to take action will help act as a deterrent for those who think they get away with a crime that directly impacts the environment, wildlife and people who enjoy the outdoors," Commissioner Martin said. "We want illegal dumpers to know that there will be consequences for their actions."
The "Don't Waste Our Open Space" program is a coordinated effort involving a host of DEP programs, including Parks, Fish & Wildlife, Solid Waste, Water Resources, State Forestry Services and the Natural Lands Trust. Investigations of illegal dump sites on state properties, including a few involving motion-sensor camera discoveries, are conducted by State Park Police, Division of Fish & Wildlife's Conservation Officers and DEP's Compliance & Enforcement.
All activities are posted on www.stopdumping.nj.gov, which serves as a hub for the program.
DEP has also introduced the "Don't Waste Our Open Space" program to municipalities and several local and county law enforcement entities in an effort to bring more attention to the issue of illegal dumping. Earlier this year, the cities of Camden, Trenton and Secaucus launched their own illegal dumping initiatives, based on the methods and successes of the state program. With direction and assistance from DEP's program, the municipalities are already seeing results.
"The city of Camden is very excited about strengthening our partnership with DEP to combat illegal dumping in our city," Camden Mayor Dana Redd said. "Inclusion of Camden in DEP's Illegal Dumping Program will fortify the ongoing efforts of Camden Metro Police, the city, and the Camden Collaborative Initiative partners to identify and prosecute dumpers who are illegally discarding wastes on our streets, residences, businesses and public spaces."
"Forging this important partnership with the DEP will better enable our town to combat illegal dumping through both enforcement and education," said Secaucus Mayor Michael Gonnelli. "The town of Secaucus looks forward to combining efforts with the DEP to protect our environment, natural resources and the beauty of our community."
"A partnership with the DEP to combat illegal dumping in Trenton is a win-win relationship," Trenton Mayor Eric Jackson added. "Not only does it strengthen our ability to keep our city clean, it exemplifies my administration's commitment to transforming our city by executing a governance strategy formed by collaboration, communication, innovation and transparency."
While partnering with the municipalities, the "Don't Waste Our Open Space" program continues to heavily enforce illegal dumping on state lands. Last month, DEP's Solid Waste Enforcement filed a Notice of Civil Administrative Penalty Assessment of $63,000 against Dennis Jenkins and Leardee Fortenberry, both of Franklin Township, for multiple violations of the Solid Waste Management Act found at a large dumpsite at D&R Canal State Park in Franklin.
"We will continue to seek maximum penalties for illegal dumping in our state parks and on our recreational properties," Commissioner Martin said.
Some recent enforcement actions in the illegal dumping crackdown include:
Jefferson Oliveira, 44, of Hammonton was charged with illegal dumping and transportation of solid waste after an investigation of a dump site in the Atsion section of Wharton State Forest led to a company owned by Oliveira called Solid Concrete Walls in Berlin. State Park Police Detective Brian Calloway, Officer Andrew Hambleton and Officer John Kline investigated.
Mitchell Storozynsky, 50, of Pemberton was charged with illegal dumping after household debris was found at Brendan Byrne State Forest. Calloway and Hambleton investigated.
Bill Howell, of Washington, DC, was charged with illegal dumping and dumping of solid waste after an investigation of a relative's household debris at Kittatinny State Park. Detective Steven Franzone and Officer Andrew Cockerham investigated.
Mark Sperbeck, 55, of Blackwood was charged with abandonment of a vessel and illegal disposal of solid waste after Calloway and Officer Sean Samson investigated a discarded boat near the Paradise Lakes campground in Wharton State Forest.
Christopher Platt, 21, of Millville was charged with illegal transportation and dumping of solid waste after auto parts and household debris were found at Belleplain State Forest in Dennis. Detective Calloway and Officer Patrick Kelly investigated.
Jodie Ballard, 64, of Princeton was charged with illegal dumping after his household trash was found dumped at the Millstone Aqueduct in Plainsboro. Officer Joseph Jackson investigated after receiving an anonymous tip. Plainsboro Police Department assisted. Ballard pled guilty and was fined $2,500.
Kevin Mitchell, 53, and Diane Mitchell, 57, of Bridgeton, were charged with illegal dumping after household waste found at Stow Creek State Park. Calloway investigated.
Joseph Protzo, 50, of Bushkill, Pa. was charged with illegal dumping after household and construction debris were found on Burnt Meadow Road in Ringwood State Park. Detective Franzone investigated.
Matthew Judson, 51, of Hackettstown was charged with illegal dumping after an investigation of two piles of household debris found in Stephens State Park, off of Waterloo Valley Road. Franzone investigated.
Marta Garay, 38, of Pemberton was charged with illegal transport and dumping of solid waste after household debris and several boxes of books were found at Double Trouble State Park in Lacey. Calloway and Officer Jeffrey Winter investigated.
Lucas W. Anderson, 18, of Highland Lakes was charged with illegal dumping after construction debris was found in Hamburg Mountain Wildlife Management Area in Vernon. Anderson pled guilty in municipal court and paid a $1,000 fine. Lt. Steven Sutton from Division of Fish and Wildlife's Bureau of Law Enforcement investigated.
Joshua Ganter, 39, of Hackettstown was charged with a second offense of illegal dumping of tree clippings at Rockport Wildlife Management Area in Hackettstown. Ganter pled guilty to the charges and paid a $750 fine. Conservation Officer Jordan Holmes investigated.
Thomas Ziniewicz, 43, of Newton was charged with illegal dumping after contents of a Recreational Vehicle were found at Paulinskill River Wildlife Management Area. Ziniewicz pled guilty in municipal court and paid a $506 fine.
Christopher Both, 19, and Adam Klein, 19, both of Allentown, were charged with illegal dumping after depositing 38 paint cans at Assunpink Wildlife Management Area. Both pled guilty and each paid a $625 fine. Conservation Officer Shannon Martiak investigated.
Lamar Langston, 32, of Cape May was charged with illegal dumping after 10 garbage bags of household debris were found at Cape Island Wildlife Management Area. Conservation Officer Craig James investigated.
William E. Wright, 21, of Petersburg is charged with illegal dumping after three large construction debris piles were found in two locations of Peaslee Wildlife Management Area in Cumberland County. Officer James investigated.
A new mobile application, which can be accessed on smart phones at https://njwebmap.state.nj.us/DEPStopDumping allows park visitors who come across illegal dump sites to anonymously report its location, the size and type of the dump, as well as a picture of the debris. Once the site is reported, DEP investigators will work to find the responsible party.
For additional instructions on how to use the mobile application, visit: www.nj.gov/dep/stopdumping/instructions.htm
The "Don't Waste Our Open Space'' program incorporates strict enforcement of illegal dumping practices, while raising awareness of the problem through outreach and education. Strategically deployed motion-sensor cameras have been set up in select state parks and wildlife management areas to help nab violators. Information on arrests and charges filed in connection with illegal dumping will be posted on www.stopdumping.nj.gov.
Illegal dumping, which includes everything from unlawful disposal of construction debris and old TVs and computers to the dumping of car parts and tires-- and even entire vehicles -- has been a growing problem in the state's vast natural holdings in all 21 counties in recent years.
Nearly all of the state's more than 170 publicly owned tracts, including state parks, state forests, wildlife management areas, marinas, and natural lands and preserves, have been impacted by illegal dumping. These lands account for 813,000 acres of state-preserved open space.
For more information on state parks, forests and wildlife areas, visit www.nj.gov/dep/parksandforests/and www.nj.gov/dep/fgw/.
Last Updated: August 6, 2015

redpajama_set_name: RedPajamaCommonCrawl


"I DISCOVERED THROUGH LEADERSHIP@VANTAGE THE SKILLS TO COMMUNICATE EFFECTIVELY AND TO HANDLE CONFLICT IN A POSITIVE WAY"
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Thabile's track record shows that she is a committed and motivated individual with good relationships with people from diverse backgrounds and that she exists to make a difference in the world. Thabile is the General Manager at Scope Leadership Development and Youth Leader at Every Nation in Rosebank, Johannesburg.
Sergé have completed numerous certified courses related to the teaching and training industry, have more than 20 years of experience in the industry and have proven to be a teacher who captivates audiences and inspires transformational action in their lives. He served on numerous boards, training teams and operational teams across various industries and in various cultural contexts and therefore adds immense value to LEADERSHIP@VANTAGE.
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When Hennie was requested to serve on the Board of LEADERSHIP@VANTAGE he committed without hesitation because of his belief in the youth of South Africa and because of his passion to develop their skills, knowledge and experience.
Noxolo Kahlana holds various degrees in social development, sustainability and leadership development. She is passionate about Economic Development Strategy and execution thereof; Small and Medium Enterprises support and incubation; Supply chain transformation (B-BBEE); Economic Development support on Renewable energy projects development (REIPPP); Sustainability reporting and energy efficiency programs. Her areas of specialty in business relates to Stakeholder relations management, business development, Socio-Economic Project management, projects monitoring and evaluation, monitoring systems development.
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I vaguely remember a song, from the late 60's I think, it was called Jam Up and Jelly Tight. Don't even remember what it was about, it just had one of these catchy melodies with lyrics that get stuck in your brain and drive you insane.
Jam Up and Jelly Tight. My my my baby, you're outta sight.
They used to say those kind of things back then, "outta sight." Now they say things like "hecka tight."
This is how boring and pathetic my world has become, doing what I can to stretch out this tight tight arm, and then these things come to me, and I add to my suffering by getting a song stuck in my head that I never really liked in the first place.
Jelly tight. I have been doing the eency weency spider exercise, letting my fingers do the walking. I don't think it's helping much.
Last night, I had my robe on while writing my blog, I was sitting on my bed. It occurred to me, why do I have my robe cinched so so tight? I loosened the bow and untied it.
Oh. Wasn't my robe at all. This tightness is INSIDE. It feels as if I should be able to loosen it, like something is around me, and I should be able to loosen it. It hasn't loosened yet.
I'm sleeping more, slept several hours last night, woke up early, then fell asleep and slept a few hours more. I've been hoping and hoping for more sleep, and this morning, when I got out of bed after 11 a.m., I felt guilty. It was weird. Like I was supposed to be doing something else or supposed to be somewhere.
I have that feeling often lately, like I am supposed to be somewhere, I just can't remember where. I only know when I get that feeling and look at the clock, that was the time I was supposed to be there. And now I'm late.
I have never not worked. Not since I got my worker's permit at 15 and a half. I have never in my life been off of work this long.
Recovery and healing is my job right now. I hope it's working. I've always been a good employee. How will I know if I'm doing a good job? How do I measure that? Will I get a review? Will I eventually get promoted to wellness?
My world seems so small right now, cause it is, so small and focused on what my body has to say. Everyday.
Feels like these doggie girls and I wait for the boys to come home, that is when the day starts, and the house comes alive again, filled with the sound of them.
When I ask Robin how his day was, he says "Adequate." That is his newest thing. It makes me laugh.
I like making him laugh. You don't know this about me. I can imitate the Elmo voice. I can sing Elmo's song, about Elmo's world, and it makes Robin laugh. He also loved when I did that when he was a baby. Except the one time, I sang so loud, only a couple of words in, his lip quivered and he cried, I scared the baby poop out of him.
This recovery thing requires great patience, diligence and spirit. It is slow slow tedious work. I know at some point I will turn a corner and will start feeling better physically. I don't know how people with chronic illness or those confined to a wheel chair or with other types of physical disabilities cope with all those continual limitations.
I am finding it a real challenge to live in a world that is so small, so much of it spent in my head.
The tree in our front yard is breathtaking beautiful right now, all shades of moss green to burnt orange. The spectrum of color is spectacular, all on this one tree, all for us, every year. There are so many dry and crisp leaves all over the lawn and the flagstone path leading to the front door.
I crunched leaves today. I stepped and crunched. Crunch. Crunch. Crunch.
Have you crunched some leaves yet this Fall?


Recently, we experienced a rare bug in which some brands reported that issues marked in Publish to "Include in Subscription" did not retain the setting after publishing, which led to subscribers not getting the issue. The bug was resolved on 11/13, however some action may still be necessary to ensure all of your customers receive the proper entitlements.
If you published an issue between 10/22 and 11/13 and have noticed a significantly lower download count or a significant uptick in customers complaining of not getting the issue, please let us know at support@magplus.com right away and we can manually restore the entitlements.
*If you have received an email from the Mag+ Support Team regarding this matter and have already responded, no further action is needed on your part.
We apologize for this inconvenience and thank you for your patience as we work to restore the proper entitlements for your customers.


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BeiGene Announces the Approval in China of BLINCYTO® (Blinatumomab) for Injection for Adult Patients with Relapsed or Refractory B-Cell Precursor Acute Lymphoblastic Leukemia (ALL)
BEIJING & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Dec. 7, 2020-- BeiGene, Ltd. (NASDAQ: BGNE; HKEX: 06160), a commercial-stage biotechnology company focused on developing and commercializing innovative medicines worldwide, today announced that the China National Medical Products Administration (NMPA) has approved BLINCYTO® (blinatumomab) for injection for the treatment of adult patients with relapsed or refractory (R/R) B-cell precursor acute lymphoblastic leukemia (ALL). The biologics license application (BLA) had been submitted by Amgen and received priority review by the Center for Drug Evaluation (CDE) of the NMPA. Developed by Amgen and licensed to BeiGene in China under a strategic collaboration commenced earlier this year, this is the first approval for BLINCYTO in China and BeiGene's first product licensed from Amgen to be newly approved. With this approval, BLINCYTO has become the first bispecific immunotherapy approved in China.
"This approval of BLINCYTO provides us with an opportunity to offer adult patients in China with relapsed or refractory B-cell precursor ALL the first approved immunotherapy treatment for their disease. BLINCYTO is the first immunotherapy to demonstrate superior overall survival versus chemotherapy, more than doubling patients' chances for survival, when used in first salvage R/R ALL in studies outside of China," commented Xiaobin Wu, Ph.D., General Manager of China and President of BeiGene. "We are working to ensure BLINCYTO is available to patients in China as soon as possible. Our commercial organization of more than 1,500 people in China is excited to add BLINCYTO to our product portfolio, which now includes six approved cancer treatments."
The approval of BLINCYTO was based on results from the Phase 3 trial (NCT03476239) in China evaluating the efficacy and safety of BLINCYTO in adult patients with Philadelphia-negative R/R B-cell precursor ALL. Results of the interim analysis of 67 patients showed that the efficacy results in Chinese subjects were generally consistent with those in the global and Japan studies in subjects with Philadelphia-negative R/R ALL. The complete response/complete response with partial recovery of blood cells (CR/CRh) rate within two cycles of BLINCYTO treatment (the primary endpoint) was 47.8% (32 of 67 subjects; 95% CI: 35.4, 60.3). The median overall survival time was 9.6 months (95% CI: 6.4, not estimable). The safety profile observed for Chinese subjects in this study was consistent with that observed in the global studies evaluating BLINCYTO in R/R ALL. No new safety risks were identified based on these interim analyses of adverse events in Chinese subjects.
"Our collaboration with BeiGene is advancing Amgen's oncology pipeline for patients with significant unmet medical needs. We are confident the approval of BLINCYTO in China has the potential to make a meaningful difference to adult patients with R/R B-cell precursor acute lymphoblastic leukemia," said My Linh Kha, Vice President & General Manager, Amgen Japan Asia-Pacific (JAPAC). "We are deeply committed to continuing to bring therapeutic options to treat debilitating cancers for patients in China, while also actively supporting the Government's focus on healthy aging through innovative products and initiatives designed to prevent chronic diseases, such as cardiovascular disease and fragility fracture."
About Acute Lymphoblastic Leukemia (ALL)
Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a rapidly progressing cancer of the blood and bone marrow that occurs in both adults and children1. ALL accounts for approximately 20% of all adult leukemia, and in China there were an estimated 82,607 new cases of leukemia in 20182,3. In children, the relapse rate of ALL is nearly 10%, while in adults the relapse rate is closer to 50%4.
About BLINCYTO® (blinatumomab)
BLINCYTO is a bispecific CD19-directed CD3 T cell engager (BiTE®) immuno-oncology molecule that binds specifically to CD19 expressed on the surface of cells of B-lineage origin and CD3 expressed on the surface of T cells.
BiTE molecules are a type of immuno-oncology therapy being investigated for fighting cancer by helping the body's immune system to detect and target malignant cells. The modified molecules are designed to engage two different targets simultaneously, thereby juxtaposing T cells (a type of white blood cell capable of killing other cells perceived as threats) to cancer cells. BiTE immuno-oncology molecules help place the T cells within reach of the targeted cell, with the intent of allowing T cells to inject toxins and trigger the cancer cell to die (apoptosis). BiTE immuno-oncology therapies are currently being investigated for their potential to treat a wide variety of cancers.
BLINCYTO was granted breakthrough therapy and priority review designations by the U.S. Food and Drug Administration and is approved in the U.S. for the treatment of:
relapsed or refractory B-cell precursor ALL in adults and children.
B-cell precursor ALL in first or second complete remission with minimal residual disease (MRD) greater than or equal to 0.1% in adults and children. This indication is approved under accelerated approval based on MRD response rate and hematological relapse-free survival. Continued approval for this indication may be contingent upon verification and description of clinical benefit in the confirmatory trials.
In the European Union (EU), BLINCYTO is indicated as monotherapy for the treatment of:
adults with Philadelphia chromosome negative CD19-positive relapsed or refractory B-precursor acute lymphoblastic leukemia (ALL).
adults with Philadelphia chromosome negative CD19-positive B-precursor ALL in first or second complete remission with minimal residual disease (MRD) greater than or equal to 0.1%.
paediatric patients age 1 year or older with Philadelphia chromosome-negative CD19-positive B-precursor ALL which is refractory or in relapse after receiving at least two prior therapies or in relapse after receiving prior allogeneic hematopoietic stem cell transplantation.
In China, BLINCYTO is indicated for the treatment of adult patients with relapsed or refractory B-cell precursor ALL.
Important U.S. Safety Information
WARNING: CYTOKINE RELEASE SYNDROME and NEUROLOGICAL TOXICITIES
Cytokine Release Syndrome (CRS), which may be life-threatening or fatal, occurred in patients receiving BLINCYTO®. Interrupt or discontinue BLINCYTO® and treat with corticosteroids as recommended.
Neurological toxicities, which may be severe, life-threatening or fatal, occurred in patients receiving BLINCYTO®. Interrupt or discontinue BLINCYTO® as recommended.
BLINCYTO® is contraindicated in patients with a known hypersensitivity to blinatumomab or to any component of the product formulation.
Cytokine Release Syndrome (CRS): CRS, which may be life-threatening or fatal, occurred in 15% of patients with R/R ALL and in 7% of patients with MRD-positive ALL. The median time to onset of CRS is 2 days after the start of infusion and the median time to resolution of CRS was 5 days among cases that resolved. Closely monitor and advise patients to contact their healthcare professional for signs and symptoms of serious adverse events such as fever, headache, nausea, asthenia, hypotension, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased total bilirubin (TBILI), and disseminated intravascular coagulation (DIC). The manifestations of CRS after treatment with BLINCYTO® overlap with those of infusion reactions, capillary leak syndrome, and hemophagocytic histiocytosis/macrophage activation syndrome. If severe CRS occurs, interrupt BLINCYTO® until CRS resolves. Discontinue BLINCYTO® permanently if life-threatening CRS occurs. Administer corticosteroids for severe or life-threatening CRS.
Neurological Toxicities: Approximately 65% of patients receiving BLINCYTO® in clinical trials experienced neurological toxicities. The median time to the first event was within the first 2 weeks of BLINCYTO® treatment and the majority of events resolved. The most common (≥ 10%) manifestations of neurological toxicity were headache and tremor. Severe, life‐threatening, or fatal neurological toxicities occurred in approximately 13% of patients, including encephalopathy, convulsions, speech disorders, disturbances in consciousness, confusion and disorientation, and coordination and balance disorders. Manifestations of neurological toxicity included cranial nerve disorders. Monitor patients for signs or symptoms and interrupt or discontinue BLINCYTO® as outlined in the PI.
Infections: Approximately 25% of patients receiving BLINCYTO® in clinical trials experienced serious infections such as sepsis, pneumonia, bacteremia, opportunistic infections, and catheter-site infections, some of which were life-threatening or fatal. Administer prophylactic antibiotics and employ surveillance testing as appropriate during treatment. Monitor patients for signs or symptoms of infection and treat appropriately, including interruption or discontinuation of BLINCYTO® as needed.
Tumor Lysis Syndrome (TLS), which may be life-threatening or fatal, has been observed. Preventive measures, including pretreatment nontoxic cytoreduction and on-treatment hydration, should be used during BLINCYTO® treatment. Monitor patients for signs and symptoms of TLS and interrupt or discontinue BLINCYTO® as needed to manage these events.
Neutropenia and Febrile Neutropenia, including life-threatening cases, have been observed. Monitor appropriate laboratory parameters (including, but not limited to, white blood cell count and absolute neutrophil count) during BLINCYTO® infusion and interrupt BLINCYTO® if prolonged neutropenia occurs.
Effects on Ability to Drive and Use Machines: Due to the possibility of neurological events, including seizures, patients receiving BLINCYTO® are at risk for loss of consciousness, and should be advised against driving and engaging in hazardous occupations or activities such as operating heavy or potentially dangerous machinery while BLINCYTO® is being administered.
Elevated Liver Enzymes: Transient elevations in liver enzymes have been associated with BLINCYTO® treatment with a median time to onset of 3 days. In patients receiving BLINCYTO®, although the majority of these events were observed in the setting of CRS, some cases of elevated liver enzymes were observed outside the setting of CRS, with a median time to onset of 19 days. Grade 3 or greater elevations in liver enzymes occurred in approximately 7% of patients outside the setting of CRS and resulted in treatment discontinuation in less than 1% of patients. Monitor ALT, AST, gamma-glutamyl transferase, and TBILI prior to the start of and during BLINCYTO® treatment. BLINCYTO® treatment should be interrupted if transaminases rise to > 5 times the upper limit of normal (ULN) or if TBILI rises to > 3 times ULN.
Pancreatitis: Fatal pancreatitis has been reported in patients receiving BLINCYTO® in combination with dexamethasone in clinical trials and the post-marketing setting. Evaluate patients who develop signs and symptoms of pancreatitis and interrupt or discontinue BLINCYTO® and dexamethasone as needed.
Leukoencephalopathy: Although the clinical significance is unknown, cranial magnetic resonance imaging (MRI) changes showing leukoencephalopathy have been observed in patients receiving BLINCYTO®, especially in patients previously treated with cranial irradiation and antileukemic chemotherapy.
Preparation and administration errors have occurred with BLINCYTO® treatment. Follow instructions for preparation (including admixing) and administration in the PI strictly to minimize medication errors (including underdose and overdose).
Immunization: Vaccination with live virus vaccines is not recommended for at least 2 weeks prior to the start of BLINCYTO® treatment, during treatment, and until immune recovery following last cycle of BLINCYTO®.
Risk of Serious Adverse Reactions in Pediatric Patients due to Benzyl Alcohol Preservative: Serious and fatal adverse reactions including "gasping syndrome," which is characterized by central nervous system depression, metabolic acidosis, and gasping respirations, can occur in neonates and infants treated with benzyl alcohol-preserved drugs including BLINCYTO® (with preservative). When prescribing BLINCYTO® (with preservative) for pediatric patients, consider the combined daily metabolic load of benzyl alcohol from all sources including BLINCYTO® (with preservative) and other drugs containing benzyl alcohol. The minimum amount of benzyl alcohol at which serious adverse reactions may occur is not known. Due to the addition of bacteriostatic saline, 7-day bags of BLINCYTO® solution for infusion with preservative contain benzyl alcohol and are not recommended for use in any patients weighing < 22 kg.
The most common adverse reactions (≥ 20%) in clinical trial experience of patients with MRD-positive B-cell precursor ALL (BLAST Study) treated with BLINCYTO® were pyrexia (91%), infusion-related reactions (77%), headache (39%), infections (pathogen unspecified [39%]), tremor (31%), and chills (28%). Serious adverse reactions were reported in 61% of patients. The most common serious adverse reactions (≥ 2%) included pyrexia, tremor, encephalopathy, aphasia, lymphopenia, neutropenia, overdose, device related infection, seizure, and staphylococcal infection.
The most common adverse reactions (≥ 20%) in clinical trial experience of patients with Philadelphia chromosome-negative relapsed or refractory B-cell precursor ALL (TOWER Study) treated with BLINCYTO® were infections (bacterial and pathogen unspecified), pyrexia, headache, infusion-related reactions, anemia, febrile neutropenia, thrombocytopenia, and neutropenia. Serious adverse reactions were reported in 62% of patients. The most common serious adverse reactions (≥ 2%) included febrile neutropenia, pyrexia, sepsis, pneumonia, overdose, septic shock, CRS, bacterial sepsis, device related infection, and bacteremia.
Adverse reactions that were observed more frequently (≥ 10%) in the pediatric population compared to the adults with relapsed or refractory B-cell precursor ALL were pyrexia (80% vs. 61%), hypertension (26% vs. 8%), anemia (41% vs. 24%), infusion-related reaction (49% vs. 34%), thrombocytopenia (34% vs. 21%), leukopenia (24% vs. 11%), and weight increased (17% vs. 6%).
In pediatric patients less than 2 years old (infants), the incidence of neurologic toxicities was not significantly different than for the other age groups, but its manifestations were different; the only event terms reported were agitation, headache, insomnia, somnolence, and irritability. Infants also had an increased incidence of hypokalemia (50%) compared to other pediatric age cohorts (15-20%) or adults (17%).
Dosage and Administration Guidelines
BLINCYTO® is administered as a continuous intravenous infusion at a constant flow rate using an infusion pump which should be programmable, lockable, non-elastomeric, and have an alarm.
It is very important that the instructions for preparation (including admixing) and administration provided in the full Prescribing Information are strictly followed to minimize medication errors (including underdose and overdose).
Please see full Prescribing Information and medication guide for BLINCYTO at www.BLINCYTO.com.
About BeiGene
BeiGene is a global, commercial-stage biotechnology company focused on discovering, developing, manufacturing, and commercializing innovative medicines to improve treatment outcomes and access for patients worldwide. Our 4,700+ employees in China, the United States, Australia, Europe, and elsewhere are committed to expediting the development of a diverse pipeline of novel therapeutics. We currently market two internally discovered oncology products: BTK inhibitor BRUKINSA® (zanubrutinib) in the United States and China, and anti-PD-1 antibody tislelizumab in China. We also market or plan to market in China additional oncology products licensed from Amgen Inc., Celgene Logistics Sàrl, a Bristol Myers Squibb (BMS) company, and EUSA Pharma. To learn more about BeiGene, please visit www.beigene.com and follow us on Twitter at @BeiGeneUSA.
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 and other federal securities laws, including statements regarding the commercialization and potential benefits of BLINCYTO®; and BeiGene's plans and expectations for the commercialization of its and Amgen's other oncology products and pipeline assets. Actual results may differ materially from those indicated in the forward-looking statements as a result of various important factors, including BeiGene's ability to demonstrate the efficacy and safety of its drug candidates; the clinical results for its drug candidates, which may not support further development or marketing approval; actions of regulatory agencies, which may affect the initiation, timing and progress of clinical trials and marketing approval; BeiGene's ability to achieve commercial success for its marketed products and drug candidates, if approved; BeiGene's ability to obtain and maintain protection of intellectual property for its technology and drugs; BeiGene's reliance on third parties to conduct drug development, manufacturing and other services; BeiGene's limited operating history and BeiGene's ability to obtain additional funding for operations and to complete the development and commercialization of its drug candidates; the impact of the COVID-19 pandemic on the Company's clinical development, commercial and other operations, as well as those risks more fully discussed in the section entitled "Risk Factors" in BeiGene's most recent quarterly report on Form 10-Q, as well as discussions of potential risks, uncertainties, and other important factors in BeiGene's subsequent filings with the U.S. Securities and Exchange Commission. All information in this press release is as of the date of this press release, and BeiGene undertakes no duty to update such information unless required by law.
BLINCYTO® and BiTE® are registered trademarks of Amgen Inc.
1 Mayo Clinic. Acute lymphocytic leukemia. https://www.mayoclinic.org/diseases-conditions/acute-lymphocytic-leukemia/symptoms-causes/syc-20369077
2 Baljevic M, Jabbour E, O'Brien S, Kantarjian HM (2016). "Acute Lymphoblastic Leukemia".
3 Global Cancer Observatory. https://gco.iarc.fr/today/data/factsheets/populations/160-china-fact-sheets.pdf
4 Leukaemia Care. Relapse in Acute Lymphoblastic Leukaemia (ALL). https://media.leukaemiacare.org.uk/wp-content/uploads/Relapse-in-Acute-Lymphoblastic-Leukaemia-ALL-Web-Version.pdf
Craig West
ir@beigene.com
Liza Heapes or Vivian Ni
media@beigene.com
Source: BeiGene, Ltd.
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BeiGene, Ltd. ("BeiGene") is a commercial-stage biotechnology company focused on developing and commercializing innovative molecularly-targeted and immuno-oncology drugs for the treatment of cancer.
BeiGene has a broad portfolio consisting of six internally-developed, clinical-stage, drug candidates, including three late-stage clinical drug candidates, zanubrutinib (BTK inhibitor), tislelizumab (PD-1 antibody), and pamiparib (PARP inhibitor). BeiGene has also in-licensed six drugs and drug candidates, including three marketed drugs in China ABRAXANE®, REVLIMID® and VIDAZA® under an exclusive license from Celgene Corporation, and two clinical-stage drug candidates with development and commercialization rights in China and other selected countries in the Asia-Pacific region.
BeiGene was established in Beijing in 2010 and listed on the U.S. NASDAQ Global Select Market in February 2016. As of February 27, 2019, the Company had a global team of over 2,200 employees. BeiGene operates as a fully-integrated global biotechnology company with broad capabilities, both in China and globally, spanning research, clinical development, manufacturing and commercialization.
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The Gym Store LLC highest bidder for FHI/Busy Body assets, plans 8-10 SoCal stores
The Gym Store LLC, a group led by majority investor Jeff Partrick, entered the highest bid for the assets of the remaining Busy Body stores of Fitness Holdings International at a court auction on Aug. 11. Held in the U.S. District Court, Central District of California, the court auction was the culmination of the Ch. 11 bankruptcy reorganization filed in October 2008 by Fitness Holdings International (FHI), which owned and operated Busy Body Home Fitness and Omni Fitness.
The Gym Store LLC, a group led by majority investor Jeff Partrick, entered the highest bid for the assets of the remaining Busy Body stores of Fitness Holdings International at a court auction on Aug. 11.
Held in the U.S. District Court, Central District of California, the court auction was the culmination of the Ch. 11 bankruptcy reorganization filed in October 2008 by Fitness Holdings International (FHI), which owned and operated Busy Body Home Fitness and Omni Fitness. Click here to read an Oct. 21, 2008, SNEWS® story, "Omni/Busy Body Home parent FHI files Ch. 11 reorganization for entire group, plans sale of stores."
Down from its peak of 114 stores, FHI has 20 stores remaining in California and one in Alaska. The winning bid for the business assets, not including store leases, was $550,000, with three bidders participating in the court auction that lasted about 30 minutes.
Partrick, CEO of Hoist Fitness, won the auction when the last bidder, Brandon Sugimoto, FHI's director of financial analysis, bowed out at $545,000. SNEWS sources said Sugimoto sat in the court hearing with FHI President/COO Kenton Van Harten and Busy Body retail manager Blair Gannam. Sugimoto had entered an opening bid proposal of $200,000 with the court on July 29, 2009. Click here to see a July 31, 2009, SNEWS story, "FHI employee is proposed buyer for Busy Body assets: $200,000 offer, with bidding open."
The third bidder was a group operating under the name "Green Giraffe" whose group bowed out at about $515,000.
Southern California operating asap
Partrick told SNEWS he and his management group plan to operate eight to 10 retail stores in Southern California from Los Angeles down to San Diego, maintaining the Busy Body Home Fitness name. He stressed the operation is a completely separate and independent company from Hoist Fitness. The deal should be done and paperwork signed to finalize the purchase by Aug. 14, he said, and stores will open "virtually immediately" under their management.
"We're still making arrangements," he said, noting how quickly the deal came together in the last few weeks. "Obviously, I've been aware of the situation, but until recently, it looked as if the current owners were going to put something together."
Since the leases were not part of the purchase, Partrick said negotiations are on the fast-track.
"We're still in the process of negotiations with some of the landlords," he said. "We're hoping to execute leases on the exact same stores" as Busy Body's current locations.
Dave Silva, a former Busy Body district manager who opened OC Gym Equipment in Newport Beach in November 2008, will merge his store into the new company and, per Partrick, will be director of store operations for the retail venture. Yossi Shimony, CEO of Pronto Installation, will take on logistics and warehousing.
"This company, meaning the company we just purchased, has a lot of great employees and a lot of great staff, and they just need the resources," Partrick said. "In the last year with the bankruptcy, they've been handcuffed. Once we take off the handcuffs and release the resources, we're going to have a great company here again."
He said they will begin interviewing the former and current FHI/Busy Body staff. At this time, he named Hoist, Octane and PaceMaster as signed suppliers with Life Fitness being likely.
Ironically, FHI had acquired in November 2003 a chain of nine Fitness Warehouse stores in Southern California, owned by Partrick and the other Hoist owners. Click here to see that Nov. 10, 2003, SNEWS story, "Busy Body snaps up Fitness Warehouse, grows to 48." That was the third of nine acquisitions for the company between 2002 and 2005 after FHI bought stores in a court auction after the former Busy Body's bankruptcy in 2001.
And Northern California?
Of the 20 stores remaining in California as of Aug. 12, 2009, eight of those are in Northern California. SNEWS learned that Scott Egbert, owner of Chicago Home Fitness, Utah Home Fitness and other "home fitness" operations, will be taking over those assets from Partrick.
"Jeff bought the assets, and I'm purchasing the Northern California assets from Jeff," Egbert told SNEWS as he was boarding a plane on Aug. 12 for Northern California from Southern California where he sat in on the auction.
He is in the process of talking to landlords and visiting stores this week, he said. Other details were not yet available as to his plans.
Meanwhile, the suit filed May 21, 2009, by the unsecured creditors committee against FHI that charged breach of duties and fraud is still moving ahead. (Click here to read a May 22, 2009, SNEWS story on that case.) Defendants Kenton Van Harten and lender Pacific Western Bank have filed briefs asking the court to dismiss the case. In addition, the court approved on Aug. 10 a payment of $555,000 to its bankruptcy financial advisor Kibel Green.
As negotiations go into high-speed in different parts of the country to finalize store sales and openings, Partrick expressed confidence about the retail operation quickly getting up to speed.
"At the end of the day, our goal is to have all the stores by Oct. 1 freshened up and stocked with our go-forward vendors," he said. "I think we're going to be successful."
--Therese Iknoian
SNEWS® View: It seems it was clear to vendors that leaving the populous Golden State without a solid retail operation run by those they know wasn't an option. We don't doubt the conversations started quickly and moved at light speed -- at the Health & Fitness Business Expo last week, we saw a number of the various players in the deal pow-wowing. The transition will likely be nearly seamless with the deal to be sealed by Aug. 14, and most of the operations probably never closing. That means it will be seamless to consumers, too, which is the best scenario since closures would mean yet more egg on the face of the fitness industry if any customers end up paying for but not getting equipment. Knowing the ambiance, professionalism and décor of the former Fitness Warehouse stores, we suspect these new operations could actually bring new levels of trust to the consumer and will lay the groundwork for growing sales as the economy seems to be hinting at a turnaround. That all seems like good news.
--SNEWS® Editors
It's a done deal: The Gym Store owns Busy Body assets, re-opens SoCal stores; NorCal separate operation
The last vestiges of the former Busy Body Home Fitness company as it was run by Fitness Holdings International have been sold to The Gym Store LLC. The Gym Store is a company fueled by a group of private investors lead by Jeff Partrick, majority investor and the CEO of Hoist ...read more
FHI employee is proposed buyer for Busy Body assets: $200,000 offer, with bidding open
An employee of Busy Body-owner Fitness Holdings International has proposed to buy all remaining assets of the bankrupt retail business, offering $200,000 in cash. The buyer, Brandon Sugimoto, has been FHI's director of financial analysis since May 2005 and, per court documents ...read more
FHI asks bankruptcy court to approve liquidation of all remaining Busy Body stores
In a motion filed by Busy Body Home Fitness owner Fitness Holdings International, the court has been asked to approve going-out-of-business sales at all remaining stores and for the business to shut down by the end of July. On July 6, a hearing on the motion was set for July 14, ...read more
Omni/Busy Body Home parent FHI files Ch. 11 reorganization for entire group, plans sale of stores
In what must seem like déjà-vu for long-timers in the fitness industry, Fitness Holdings International filed for Chapter 11 bankruptcy reorganization Oct. 20 for its entire group of retail holdings, east and west, a little more than seven years after the Busy Body Home Fitness ...read more
LA Gym name to disappear, stores becoming Busy Body Home Fitness
The LA Gym retail name will disappear as of this week, officially being turned into additional Busy Body Home Fitness stores by parent of both, Fitness Holdings International. "As we look at how we're going to grow the company, it doesn't make sense to have both brands," Kenton ...read more
Busy Body parent FHI nabs LA Gym, will leave brand as-is
Despite saying in May that the company "had Southern California covered," Busy Body's parent Fitness Holdings International has done it again: This time, buying LA Gym Equipment in a deal that will leave the new holding with its own brand and name. "They saw value in LA Gym and ...read more
FHI to gut business: Omni to close out, Busy Body sliced, what's next?
On the evening of Feb. 23, when the Omni Fitness website home page changed to a stark scream of 50 percent to 90 percent off all inventory, the writing was on the wall. That morning, several insiders told SNEWS®, the district's employees had been called to a surprise conference ...read more
Omni/Busy Body Home parent FHI notes liabilities of $28.8 million in court documents
In statements of financial affairs required by the courts in bankruptcy cases, Fitness Holdings International has said it has liabilities of $28,791,811 but assets of only $23,480,884. Of those liabilities, $18.8 million are to its bank as a secured creditor, according to 418 ...read more
The FHI/Busy Body bankruptcy: Gaining perspective with history and a peek at the future -- Part 1
In the first part of this story, SNEWS will take you through a review of the history behind Busy Body with perspective on the first incarnation and the building of the second incarnation that eventually ended in a late 2008 bankruptcy. In our second part on Feb. 15, we'll review ...read more


Throughout the decades, there have been several inspirational individuals in professional sports who broke through social barriers. We can go back to 1947 when legendary Jackie Robinson became the first African American major league baseball player. Since then, Major League baseball and other professional sports have slowly worked to become very diverse with race and ethnicities from all over the world. On February 23rd 2014, a new social barrier was broken when 35-year-old Jason Collins became the first openly gay man to sign a North American professional sports league contract.
The signing was a significant step to encourage and welcome more openly gay athletes. "Today Jason Collins tore open the last remaining closet in America," said Brian Ellner, a founding member of Athlete Ally, a nonprofit that raises awareness about homophobia in sports, in an interview for the New York Times. "This is a piece of history, an important point on the continuum toward justice and a moment to celebrate." Many men within professional sports do not reveal or otherwise discuss their sexuality, and prefer not to publicize it. That being said, no matter what the makeup of an athlete is, it should never change the decision if he or she should be selected for a sports team.
"Its just the media making a big deal. Male, female, black, white, gay, or straight it doesn't matter. When you set foot into any locker room only one thing matters: winning. Can this guy help us win? And the answer is yes. That should be the only thing that matters. If a teammate or coach has a problem with a homosexual teammate or player, then they are disgracing the sport and are in the wrong business," said senior Manhattanville basketball player Jack Bramswig. Clearly the motive for the Nets wasn't just because he was homosexual, but in the need for Jason Collins.


After college basketball was left with no undefeated teams remaining, Michigan State earned top honors while Kentucky and UNC dropped out of the top 10 and Oklahoma and Texas Tech climbed the rankings.
It's been two weeks since our last power rankings after taking last week off due to the holiday break. Since then, six of our top-10 teams have lost, including No. 1 Villanova, and college basketball is now left with zero unbeaten teams. Because of the two-week break, the new rankings will take all games since the last edition into account (and list them under 'last week'), which for most teams means both its final nonconference game(s) and the start of conference play.
The Spartans take this spot over Duke (yes, even despite their mid-November loss to the Blue Devils) by the slimmest of margins. Michigan State has been feasting on lower competition for the last month, but things are about to change as it resumes Big Ten play with a visit from Maryland on Thursday and a trip to Columbus this weekend. Will Cassius Winston continue his incredibly hot shooting into the New Year? The sophomore has improved markedly so far in 2017–18, including connecting on 59.5% of his three-point tries in December.
Playing in just their second game since their loss to Boston College, the Blue Devils survived a tough test from Florida State over the weekend. Duke relied heavily on its starters and Marvin Bagley once again produced a monster stat line with 32 points and 21 rebounds on 13-of-17 shooting. At 100–93, the game was a shootout, which might be the way the Blue Devils are going to win many of their games in the ACC right now. They've given up at least 1.0 points per possession (PPP) in all seven games against top-100 opponents, but their top-ranked offense is remarkably strong and efficient, and they're controlling the offensive boards better than anyone in the country in rebounding 43.0% of their misses. Against FSU, they had a whopping 23.
Saturday was a day to forget for the Wildcats, who got absolutely annihilated defensively in a surprising 101–93 loss to Butler. The Bulldogs scored 1.40 PPP, the highest mark a team has had against Villanova since Virginia posted 1.43 back on Dec. 19, 2015. Butler has been 'Nova's kryptonite of late, having won three straight now in the series (it's also one of just three teams to have beaten the Wildcats since the start of the 2016–17 season). On Saturday, Butler nailed 15 of its 22 three-point tries to help spring the upset despite Villanova having a strong offensive game of its own. The outing put a notable dip into 'Nova's overall adjusted defensive efficiency ranking (now 25th), and it's got two tough defensive tests up next in visits from Marquette and Xavier.
The Sun Devils became the last team to fall from the ranks of the unbeaten with a loss at Arizona late Saturday night. Despite an off night from nearly everyone not named Tra Holder, ASU nearly pulled off a comeback in Tucson. Even with the strides made in their frontcourt, the Sun Devils couldn't stop Deandre Ayton, and a poor shooting night from both inside and outside the arc doomed them. The Wildcats now have a leg up on ASU in the Pac-12 race, which already looks like it's going to be a two-team battle. That means even though it's only played one conference game, Arizona State's margin of error now is likely slim if it wants to challenge for the Pac-12 regular-season title, something it has never won.
The Musketeers have won their last six games by an average of just 5.3 points, which depending on your perspective could be a bubble waiting to burst or evidence that this team knows how to close out tight games (or…both?). One thing that helps in close games is free throws, which is an area that Xavier has improved in significantly. Last season, the team shot just 68.8% from the charity stripe, but it's up to 78.9% in 2017–18, the sixth-best mark in the country. The Musketeers didn't have their best night at the line against Butler, hitting just 24 of 37, but all but two of their points in the final five minutes came from there as they moved to 3–0 to open Big East play.
Don't look now, but the Boilermakers have quietly crept up to No. 3 on KenPom.com, which is eight spots higher than they ever reached last year when they still had Caleb Swanigan. Their thorough handling of Butler a few weeks ago looks even better after the Bulldogs knocked off Villanova, putting them in good position as they get ready to resume conference play. Like the Pac-12, the Big Ten already has a feeling of a two-team race between Purdue and Michigan State. The Spartans are the nation's top-ranked team and still the conference favorite, but don't overlook the Boilermakers and the many ways they can beat you.
The Sooners have continued their surprising march to an 11–1 start, most recently knocking off previously undefeated TCU on the road. Oklahoma now has two road wins over teams that were ranked in the top 10 when it happened (the other was Wichita State), and it will get even more opportunities as Big 12 play heats up. And while Trae Young has continued to post stellar numbers in his freshman season, he's not the only reason for Oklahoma's success. In its last four games, sophomore Kameron McGusty has started to turn it on, posting four straight games of double-figure scoring (his previous season-high was nine) and tying his career-high with 22 in the win over the Horned Frogs.
The Mountaineers got conference play started by picking up two solid road wins, which is always crucial in the Big 12. They did it despite uncharacteristically turning the ball over 18 times in both games, something that's a little easier to get away with when you force miscues at the rate that WVU does. It now has a big showdown with Oklahoma this weekend in what should be a track meet, as the Sooners rank fifth in average tempo and West Virginia ranks 24th. Oklahoma has taken pretty good care of the ball this season, but Trae Young has been susceptible to turnovers at times and the Mountaineers will need to exploit that.
After its in-state rival grabbed all the positive headlines out of the Pac-12 in the first two months of the season, Arizona reminded everyone why it was the preseason favorite in the conference with a gutsy home win over the Sun Devils to open league play. The Wildcats got another big game from both Deandre Ayton and Allonzo Trier, though Ayton's career-high six turnovers (including a particularly poor one in the final two minutes) were a reminder of his youth. Ayton's control of the boards (he had 19 of Arizona's 40) was a key factor, with five of his six offensive rebounds keeping possessions alive that either he or a teammate eventually scored on.
The Cavaliers hung on to edge Boston College by one in their ACC opener thanks to Ty Jerome, who scored a career-high 31 points in the 59–58 win—or 53% of their points on the day. Like it does against so many teams, UVA made the Eagles play at their pace, holding the game to just 61 possessions (for context, BC's upset win over Duke featured 74). Virginia will need more of the same when it faces two top-35 offenses next in Virginia Tech and UNC.
On Tuesday night, the Red Raiders did something they'd never done before in 17 previous tries: they beat Kansas at Allen Fieldhouse. Texas Tech led from wire-to-wire in an impressive 12-point win, which featured five players hitting double figures. Before that, they opened Big 12 play with a 25-point win over Baylor (who was without Jo Lual-Acuil). The Raiders played one of the weakest nonconference schedules in the country, but they're quickly proving they're a legit player in the loaded Big 12—and perhaps even a serious threat to win it.
Immediately after they rose into the top-five in our last power rankings two weeks ago, the Tar Heels went out and lost to…Wofford? It was one of the shockers of the season so far, but UNC made sure it didn't snowball with a solid performance against Ohio State in New Orleans. Luke Maye has cooled off a bit after his torrid start, mainly due to struggling inside the arc, where he's shot 10 of 31 over the last three games. North Carolina has two big road tests up next, including at the nation's most adjusted efficient defense in Virginia. After the way it struggled back in November against a similarly-elite defense in Michigan State, this is an opportunity to either show growth or start a negative trend.
The Wildcats got through their trio of late nonconference tests at 2–1, which considering their immense youth (under all that talent) can be considered a success. Their 90–61 win over rival Louisville in response to the UCLA loss was particularly impressive, but it was even more important that they didn't suffer a letdown against Georgia on New Year's Eve. Now, though, Kentucky must do something it has yet to do all season: play a true road game. LSU won't pose the toughest environment as the Wildcats' freshmen get their feet wet, but a weekend trip to Knoxville will serve as a solid barometer.
The Pirates got a scare from a short-handed St. John's team, but Desi Rodriguez was there to save the day with a jumper in the final 15 seconds that sealed the win. He finished with 23 points, the sixth time this season he's reached the 20-point plateau—and all six came against Power 5 opponents. Seton Hall went 6–0 in those games, with Rodriguez scoring 12 and 15 in its two losses. Over the last two seasons, the Pirates have gone 12–3 when Rodriguez scores 20 or more—and 19–4 when he scores at least 17. It's hard to overstate the senior's importance.
In its one-point home loss to Oklahoma, TCU shot better from outside the arc than inside it, where it went just 22 of 55. It was blocked 10 times on the day and sophomore Jaylen Fisher had the least efficient game of his career, scoring no points and turning it over three times. So how did the Horned Frogs respond against Baylor, a team with a better block rate and similar two-point defense as the Sooners? Quite well. Fisher recovered with a 15-point outing on 5-of-7 shooting and TCU shot 54.1% on twos and was blocked just four times. The Frogs nearly squandered a second-half lead but pulled it together in overtime for the road win.
It's the dawn of a new era for Wichita State as it started its first-ever AAC slate with a road win over UConn. And in good news for the Shockers (and probably bad news for opponents), Markis McDuffie is finally back. He's still being eased in, having logged nine and 16 minutes in his first two games, but his presence once he gets back up to speed could be a pivotal and stabilizing factor for Wichita, which doesn't face what's likely its biggest challenger for the American crown, Cincinnati, until Feb. 18.
Let's go back to Dec. 23 for a second. On a trip to Hawaii for the Diamond Head Classic, the Hurricanes suffered a dismal offensive outing against New Mexico State, resulting in their first loss of the season. Miami scored just 54 points on 0.79 PPP, shot 2 of 18 from three and just 34.0% overall and turned it over 14 times, all ugly numbers. It was clearly an off night—and came over 4,000 miles from home two days before Christmas, but the 'Canes offense overall ranks 68th in the country in efficiency, so there's room for improvement there.
The Bearcats have now held five of their six opponents since their loss to Xavier to below 1.0 PPP, a good sign considering how much of a staple their defense is. Offensively, Cincinnati has been a very balanced team; per KenPom.com, it has five different players taking at least 21% of shots when on the floor—but no one taking more than 23.9%. Having that kind of balance can be advantage, but a lack of a go-to guy can also sometimes be costly in close games, of which Cincinnati hasn't played many of yet this season.
The Zags took a tough two-point loss at San Diego State before Christmas in which they failed to score 1.0 PPP for just the second time this season. Gonzaga let a win get away despite the fact that the Aztecs shot just 36.1% from the field and got outrebounded. Sixteen turnovers and six missed free throws hurt the Bulldogs, but all three of their losses on the season so far are respectable (San Diego State is ranked No. 51 in RPI and No. 55 on KenPom.com). It's hard to glean too much out of the Zags' first two WCC wins over Pacific and Santa Clara, nor from its upcoming schedule until a Jan. 18 date with Saint Mary's.
The Aggies had the biggest fall of anyone from two weeks ago after starting SEC play 0–2. A&M looked like a legitimate national threat a month ago—and it still can be—but it's hurting right now due to suspensions and a key injury. J.J. Caldwell, D.J. Hogg and T.J. Starks were all suspended for a win over Buffalo (Caldwell was also previously suspended four games to open the season), with leading scorer Hogg being suspended an additional two games against Alabama and Florida. That was especially consequential given the injury to Admon Gilder, who's missed the last four contests. On the court, you can't take a full picture from the Aggies' back-to-back double-digit losses because of who they were missing, but they clearly can't afford to keep running into trouble off of it.
The Tigers took care of business in their ACC opener and now get a BC team that beat Duke and took Virginia down to the wire. One of the reasons for the Tigers' early success so far this season has been the improvement of Donte Grantham, who's made a nice jump as a senior. The forward has upped his scoring from 7.3 ppg a year ago to 14.6 and his rebounding from 4.3 per game to 6.5. Most notably, his shooting has improved from 38.3% from the floor to 60.7%, with his effective field-goal percentage going from 46.4% to 66.8%, which is currently the 35th-best mark in the country. The biggest difference for Grantham has been his play at the rim, where he's making an astounding 88.3% of his shots as compared to 55.4% last year, per Hoop-Math. And unlike last year, half of his shot attempts are now coming at the rim rather than from three.
Yes, yes, it's only January 3 and the Jayhawks have 17 conference games left. But it honestly might not be too soon to start wondering if their incredible Big 12 regular-season title streak is in jeopardy. Kansas didn't lead once in a loss on its home floor to Texas Tech Tuesday night, dropping a second game this season at Allen Fieldhouse for the first time since…2006–07. That year, the Jayhawks went on to win 14 straight after that second loss, but don't expect a repeat. Until it gets Silvio De Sousa and Billy Preston on the court, KU is undermanned and undersized and often very reliant on perimeter shooting. When those shots are falling, like they did in its recent road win over Texas, good things can happen. When they're not, like they weren't against the Red Raiders, it's a hard thing to overcome for a team that ranks dead last in the country in free-throw rate.
The Mustangs have been flirting with cracking the top 25 of these power rankings for a while now, and finally get the nod this week. After beating UCF to start AAC play, SMU has four top-80 wins, most notably its win in the Bahamas over Arizona, which will only grow in value. One interesting thing benefitting the Mustangs right now is that they lead the country in defensive free-throw percentage, where opponents are shooting just 63.2%. It's something SMU has little-to-no control over, and if that starts to swing it could make a difference in close games, especially since it hits just 67.3% as a team itself from the charity stripe.
The Gators' roller-coaster season is back on the upswing after starting SEC play 2–0, including a 17-point road win over a short-handed Texas A&M team. Even though the Aggies were without two starters, Florida showed what makes it so dangerous by knocking down 17 threes (on 60.7% shooting), with five different players hitting at least two. When the Gators' "Big Three" on the perimeter are hitting from deep, they're hard to beat. Consider this: in UF's four losses, Jalen Hudson, Chris Chiozza and Egor Koulechov shot a combined 16 for 52 (30.8%) from three. In the Gators' five wins against teams from the top seven conferences, the trio went 43 for 72 (59.7%) from beyond the arc.
It's time to start talking about Auburn. The Tigers' season got off to an inauspicious start before its opener was even played when assistant Chuck Person was one of the coaches indicted in the college basketball FBI probe, but it hasn't seemed to affect their on-court play. Since an early neutral-court loss to Temple, Auburn has reeled off 11 straight wins. And while many of those weren't overly impressive—its win over Middle Tennessee was its best entering SEC action—it made a statement by beating Tennessee in Knoxville Tuesday night. The SEC looks quite deep this year thanks to several teams currently playing better than expected, but the Tigers may be able to make some noise.
1. Gonzaga: The Zags stumbled at San Diego State but remain on top here on the strength of their overall résumé.
2. Saint Mary's: The Gaels are on an eight-game win streak and got an important win over BYU over the weekend to remain in place to challenge Gonzaga in the WCC.
3. Nevada: The loss to San Francisco to close out nonconference play was a bit of a head-scratcher, but the Wolf Pack are still the favorite right now in a strong Mountain West.
4. New Mexico State: The Aggies notched an impressive win over Miami in Hawaii, but couldn't pull off the double in a five-point loss to USC.
5. Missouri State: With Wichita State having moved on to the AAC, the Bears are looking like the favorite in the Missouri Valley.


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Roster projection 3.0
We're getting closer to a regular team
By Ethan Witte@ethan_witte Mar 8, 2021, 8:00am EST
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Now that we've gone through about a week's worth of games, it's as good a time as any to try and project what the initial roster for Opening Day is going to look like. Some injuries, some hot starts to the games have changed things a little bit with perhaps one surprise addition to this list.
Catcher
J.T. Realmuto, Andrew Knapp
There shouldn't be much of a surprise here. Realmuto is going to be ready for the first series, but even if he's not, he won't be gone long enough to make this worth changing. Anything that has him missing time is just a hot take waiting to be noticed.
There might have been some idea that maybe, somehow, some way, Jeff Mathis might sneak on the roster ahead of Knapp as a defense first option that the pitchers would love to throw to, but that doesn't take into account that the team genuinely loves Knapp. The pitchers love throwing to him, his teammates love his personality, so there isn't a reason to get rid of him for the single digit wRC+ Mathis.
Rhys Hoskins, Jean Segura, Didi Gregorius, Alec Bohm, Brad Miller, C.J. Chatham
Again, no changes here. The infield is set and the backups haven't been beaten out thus far by anyone in camp, so this should be the group that heads north. Chatham might have been a victim if the team decided to go with a big bullpen, but with Girardi's desire to stick with 13 men in the bullpen means he has a good chance of sticking.
Andrew McCutchen, Scott Kingery, Bryce Harper, Roman Quinn, Odubel Herrera
Ah, here is where the fun begins.
Obviously, Adam Haseley would've been the leading candidate to start and get the lion's share of a platoon. His injury and the subsequent missing of time means he won't be ready to return until right during the week of the first games. With minor league options available and alternate site being planned for minor leaguers, it's probably safe to assume that unlike Realmuto, Haseley's injury will mean he'll begin in the minor leagues.
That leaves room for someone to take a spot and that brings us to Herrera.
Thus far, he has been playing well this spring. He's hitting for power and playing a good defense. He's competing directly with Mickey Moniak for a spot and the team's probable desire to give Moniak consistent at bats gives Herrera a leg up. The reports and redemption stories about Herrera give the situation a feel of preparing the fanbase for his return. With Haseley's injury, someone is going to have to grab that fifth outfielder's spot and it just seems like the stars are aligning for Herrera to come back.
Of course, there is the issue of his needing a 40-man spot and what happens when Haseley comes back, but for now, we won't worry about that for now.
Starting pitching
Aaron Nola, Zack Wheeler, Zach Eflin, Chase Anderson, Matt Moore
Alright, the fourth and fifth spot in the rotation is a battle. Anderson and Moore are fighting with Vince Velasquez and the loser probably goes to the bullpen. Anderson's hammer curveball the other day was truly something to behold, but of course we can't project him into the spot because of one pitch. Instead, it's just the feeling that the guaranteed money they are receiving by an incoming leadership group will win the day when it comes to picking who might pitch every fourth and fifth day will influence the decision to a point.
Relief pitching
Hector Neris, Jose Alvarado, Conner Brogdon, Archie Bradley, Jojo Romero, Tony Watson, Brandon Kintzler, Vince Velasquez
The biggest battles of the spring are for the bullpen spots and many of them have been up to the task. There have been a lot of swings and misses from those battling for a job, which is amazing because last year's lot weren't able to generate those swings and misses.
What's interesting will be that some of the guys who are doing well - Sam Coonrod, Hector Rondon, David Hale - aren't here on this list. Hale feels like the first one up to be DFA'd in order to get a spot open for Herrera, while Coonrod can be optioned to minor league camp and Rondon might be a candidate for the taxi squad. This is still the position to watch in the coming weeks for the most changes that might happen.
The taxi squad is an interesting spot. The rules state that with the five players on it, one of them must be a catcher. That seems to leave Mathis as traveling with the team often since they'll want Rafael Marchan to play regularly. Two of them seem to be locked for relievers, meaning Rondon and maybe another NRI that the team can carry since the taxi squad guys don't have to count toward the 40-man roster. That would also mean someone like Matt Joyce or Travis Jankowski or Ronald Torreyes would be in the running for the other two spots. Ideally the taxi squad would be veterans who are used to bench roles and don't necessarily need regular playing time in order to be effective. All of this will probably change in a few weeks anyway.


Thank you for coming out each and every Saturday to the most talked about party in paterson. Ladies free and bottles $70 before 11. For guestlist you must text BESO to the number 555999. For more information please feel free to contact us at 2019200089.


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News: Giant crater may lie under Antarctic ice
http://space.newscientist.com/article/dn9268
that in the time of Pliny tradition pretended to be the product of the foam of a quantity of serpents, grouped and interlaced together. This egg has been the origin of a crowd of superstitions, which, up to a century ago, were in vogue in Cornwall, Wales, and the mountains of Scotland; they continued to carry these balls of glass, called serpent stones, to which they attributed particular virtues."
Druidesses of Gaul had a sanctuary on the Isle of Sena, Finisterre. Druidism in France was condemned as late as 658, by the Council of Nantes; and, later on, by the Capitularies of Charlemagne. Renan supposed that Druidism remained a form exclusively national. Justin's remark, that "the Greek colony of Marseilles civilized the Gauls," may help to explain how Gaulish Druids knew Greek, and how some French writers traced Druidism to the Phocians of Southern Gaul. Then, again, we have Ammianus Marcellinus saying, "The Druids were formed into fraternities as the authority of Pythagoras decreed." Cæsar, in his account of Gaulish Druids, had clearly in his mind his own country's faith. They were like his own augurs, and their Archdruid was his pontifex maximus.
D'Arbois de Jubainville, in his account of Irish Mythology, has, of course, references to the Druids. He lays emphasis on the difference between those of Gaul and those of our islands. The judicial authority was vested in the Filé. These need not, like the Druids proper celebrate sacrifices. He traces the word file, a seer, from the same root as the Breton givelout, to see.
The French author records that Polyhistor, Timagenus, Valerius Maximus, and others wrote of the north-western men holding Pythagorean doctrines; but he adds, that while a second birth was regarded by the Pythagoreans as a punishment of evil, it was esteemed by the others as a privilege of heroes.


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text:
Wantirna College
VIC Wantirna College All Secondary 1980 1394 Wantirna Feature
Address Harold Street, Wantirna VIC 3152
Web Site www.wantirnacollege.vic.edu.au
Wantirna College, located in Wantirna, Victoria, is a state-government school founded in 1980 when the surrounding area was developed from fruit orchids into housing estates. The school services the general suburb of Wantirna and parts of Wantirna South and Bayswater. Today, approximately 1500 students are enrolled and over 100 staff are employed. The school offers education for students studying years seven to ten, as well as the Victorian Certificate of Education for students in years 11 and 12.
Click here to find school catchment area / boundaries.
to be filled
Contact Wantirna College to request Local Enrolment information.
Contact Wantirna College to request International Enrolment information.


Thanks everyone that submitted links to your work on our two calls for art!
We've been keeping tabs on everyone that submitted and we'll be giving you the ultimate lineup for both shows later this week!
Thanks again to everyone that submitted! We're super excited to put these shows together! We'll be contacting our final list of artists shortly and will be posting names of everyone that made it in!
Keep a look out for the list of exhibiting artist for these shows in a future post or two!
Thanks again for sharing your work and getting the word out!
We'll have more collaborative shows coming up - keep a look out!
This will certainly upgrade your collection once again to the Hard disk. Official Site Which are no more readily available on the iTunes application shop.
so, finally we are at the end. really good that you share such useful information with us.


The Premier League leaders triumphed 2-0 in the first leg and are firm favourites to reach the semi-final, where they will face either Barcelona or Manchester United.
Porto were thrashed 5-0 at home by Jurgen Klopp's side at the last-16 stage last season, while they have never before overturned a two-goal first-leg deficit in the competition.
Conceicao admits they will be facing a formidable test, but he is relishing the chance to go toe-to-toe with the five-time champions of Europe.
"There is no greater motivation than to be competing in a quarter-final and to make a historical turnaround," he told a news conference on Tuesday. "I like the way Liverpool play. Sometimes, they are the best team in the world.
"We have a two-goal deficit to make up against a very strong team who are quick on the break. Getting the attacking balance right is fundamental.
"The technical team will establish the game plan, then it's up to the players to put it into action. They are responsible for everything good that has happened so far.
"We have to work for defensive organisation and we are 100 per cent focused and aware of what our opponents are doing. It is not difficult to analyse Liverpool, but it is difficult to counteract because they have so much individual and collective quality. They're great!"
Midfielder Hector Herrera says vengeance for last year's emphatic defeat is not on the players' minds as they aim to beat Liverpool in a European match for the first time.
"There is no desire for revenge," he said. "Last year's result is in the past. We have a great opportunity to continue to make history and we do not want to waste this opportunity. In the first leg, I saw that we can hurt a team like Liverpool.
"They have the advantage, but I believe in the ability we have as players and as a team. I am very confident, and I believe we can get a good result and continue to keep our Champions League dream alive."


The home automation system is a tool for controlling your home devices and communication devices as well. For instance, you already bought your laptop, installed your backyard watering system, and subscribed your pay-TV, but what are the equipments that you will utilize to get these things connected.
You will need interfaces like switches and remote controls for controlling various devices in your home. Different devices need different hubs for setting up connections. You will need multi-zone controls, video modulators, and distribution panels for audio distribution. You will need an interface card for your network and a router for every computer for setting up LAN.
You need to learn the basics by understanding each equipment description used in making your home automation possible.
1. Wiring closet. It is an enclosed small room specifically designed for keeping jumbled wirings and provides easy access when necessary. The best location for a wiring closet is the front space of your home so that external wiring (cables used on pay-TV) can be also kept. All input devices are set up in one location, a hub. This location can get messy due to the wirings different direction.
2. Patch Panel. The brain of the hub which controls every cable in your home. Take for instance, cable X is connected to speaker Y to Z stereo. Cable functions can be changed using the patch panel by unplugging one socket and patching or plugging it back into another. Make sure that you label the cables clearly.
3. Connectors. Connectors have various types depending on what the wirings require. Outlets also vary. Cables for your speakers may also use several sockets and plugs. Take this into consideration when laying wall sockets and cables. As much as possible, it provides you with flexibility. Likewise, don't forget installation of ample power outlets.
4. Keypads and touch screens. Touch screen controls are the most expensive and intuitive types of interface while keypads provides a more simple way of communication with your gadgets.
5. Smart switches. The flexible and simple ways of initiating control is through smart switches panels which can also change dynamically. This advanced system is integrated with both entertainment and lights. It provides dimming lights options or increasing audio volumes. However, the switch used must be the same.
6. Remote controls. Universal remote control can operate televisions, air conditioners, blinds, and lights. But this equipment is very expensive because of its multiple controls. Simpler controller is another good option because it performs different tasks and eliminates the use of separate controls.
7. Computer software. Home automation can functions with the use of a software installed on a PDA (personal digital assistant) or PC (personal computer). Home controls can be done through a secure, special webpage. It means that your heating system and other devices can be turned off wherever you are.
8. Impedance matching system. This fixes problems concerning sound qualities (degradation impedance). Multiple connections of speakers on a single amplifier are possible however it reduces the amplifier's overall power.
9. Multi-zone control systems. This works like patch panels in your hub systems. You can accept feeds from different audio sources and send it to specified amplifiers located anywhere in your house.
10. Distribution panel. This can spilt video feeds anywhere in your home. This component serves as the video hub of your network. A TV signal which is fed on the distribution panel can be send to all the televisions in the house. Amplifying the output is needed because splitted signals display weaker results.
11. Modulator. It manages the inputted feeds from different devices producing videos such as a DVD player, VCR, pay-TV receiver, and security camera. The modulator selects the input channeled on your distribution panel. Multi-channeled distribution panel and modulators send feeds to various rooms from various devices simultaneously.
12. Router. This is important whether you are setting up a wireless or cabled LAN (local area network). It accesses you to the Internet and network from the different locations in your house. All computers, printer, modems, and related peripherals connected to the router can communicate with each other.
13. Network interface cards. NIC connected to the routers also allows network communications in your house.
Learning the different equipment for your home automation systems is a fun experience.


How is the New User Notification (Email verification) called?
Home>Topics>How is the New User Notification (Email verification) called?
Home › Forums › Pie-Register 2.0 Support › How is the New User Notification (Email verification) called?
This topic contains 2 replies, has 2 voices, and was last updated by Pie Register 4 years, 3 months ago.
However, I also use One-all's Social Login plugin so people can login/register with Facebook. I would like to hack their plugin to call the new user notification functions in Pie Register, but cannot quite work out which functions are used by Pie register to perfomr its magic!
Can anyone help me on this please? Support?
variables to make it working.