Lyon Distilling Company Announces Expanded Distribution to Delaware & Connecticut – LYON DISTILLING CO.
ST. MICHAELS, MD (Feb. 9, 2018) – Lyon Distilling Company of St. Michaels, MD is proud to announce expanded distribution into Delaware and Connecticut.
After four years of success in Maryland & Washington, DC with a line of signature rums and ultra small-batch whiskies, Lyon Distilling Company is thrilled to expand distribution to neighboring states. In Delaware, Lyon rums are now available through Craft Wine & Spirits, their existing distributor in Washington, DC since 2016. In Connecticut, Lyon is forming a new distribution partnership with Highland Imports.
"Delaware is a natural next step for us – with the proximity of the distillery to the shore and the ever-increasing demand for artisan spirits in towns like Wilmington, Lewes, and all the beaches, we are so excited to provide these spirits aficionados with a truly unique and spectacular rum," said Jaime Windon, co-founder and president of Lyon Distilling Company.
As for the move north, co-founder and master distiller Ben Lyon originally hails from New England, and will be on the road this month personally promoting the rums throughout Connecticut, with a spotlight on those counties in the NY metro region. "With a total focus on artisan brands, Highland Imports was a perfect partner in our expansion to the Northeast," said Lyon. "I'm thrilled that we're now able to fulfill demand in a sophisticated market like Connecticut," he added.
Lyon Distilling Company is Maryland's premier craft distillery, committed to producing small-batch, authentic spirits by hand on the Eastern Shore in Saint Michaels, Maryland since 2013. Tours & tastings are offered daily at the distillery, as are bottle sales. Notably, Lyon self-distributes their spirits to retailers & restaurants throughout Maryland.
Lyon Distilling Company's flagship spirit is rum: double distilled in tiny batches, from a unique hybrid of American cane sugar & molasses, in classic pot stills. The signature series includes a dynamic and distinctive trio of White Rum, Dark Rum, and Sailors Reserve "reposado-style" Rum. Additionally, an overproof series – including a 151 Rum – a line of inspired liqueurs, experimental spirits, and seasonal releases of whiskey – Maryland Free State Rye Whiskey, American Malt Whiskey and New Make Corn Whiskey – are also available in limited quantities at the distillery.
Craft Wine & Spirits has distributed fine wines, handcrafted spirits and beverage-related supplies to retailers and restaurants throughout Washington, DC since 2012. Owners Raul Mejia and Shannon Crisp are thrilled to expand into Delaware this year, choosing Lyon Distilling Company as one of the select brands for the launch, and all look forward to continuing the existing relationship across DC & DE.
Highland Imports opened in 2011 with a mission to offer a portfolio comprised of artisan brands, private labels, and small batch producers. "We maintain close relationships with our other brands, and we've had our eye on Lyon Distilling for the last few years, so we're thrilled to add this as the only rum brand in the portfolio," noted President, Oliver MacKinnon. With the continued growth of Artisan spirits market share, Highland Imports is honored to represent Lyon Distilling Company in Connecticut. Highland Imports will launch with Lyon Dark Rum, and expand offerings the coming months.


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text:
Home » Sennder raises $160 million for European digital freight forwarding platform
Sennder raises $160 million for European digital freight forwarding platform
Six-year-old startup bought Uber Freight's European arm last year, now plans expansion to new European markets.
The majority owner of Uber Freight's European arm, a German digital freight forwarding startup called Sennder, has raised a $160 million venture capital round and plans to split the money between further developing its technology platform and expanding into new European markets, the firm said Wednesday.
The "series D" round came from the investment firms Accel, Lakestar, HV Capital, Project A, and Scania. It follows a busy year for the six-year-old firm; during 2020, Berlin-based Sennder merged with French competitor Everoad in June and then acquired Uber Freight's European business in September. Uber Freight's parent company, the ride-hailing pioneer Uber Technologies Inc., still holds a minority stake.
Of the money raised, Sennder plans to devote $100 million to advancing its technology, which is meant to the digitalize the European trucking sector, and it will keep the remaining $60 million "to drive an expansion into new European markets with a focus on strategic partnerships," the firm said.
Sennder's platform directly connects enterprise shippers with trucking companies, bringing greater transparency and efficiency to both carriers and shippers. In particular, the firm says it is well-positioned to connect small and mid-sized trucking companies with established shippers, providing them with access to loads. Sennder uses all that data to optimize route efficiency, reduce the environmental impact of road freight, and decrease the cost of transportation, the firm said.
"Just 18 months ago, we led Sennder's Series C fundraising," investor Christoph Schuh, Investment Partner at Lakestar, said in a release. "Ever since, Sennder has successfully demonstrated its ability to massively grow the business organically and via M&A. We are delighted to see Sennder now positioned as a leading pan-European digital freight-forwarder. Especially in these unprecedented times, Sennder shows how important digitization is for the logistics industry, paving the way for an efficient future."
Editor's note: This article was revised on January 14 to include the names of additional investment firms involved in the round.
sennder raises $160m in Series D financing ?? Today our headcount is over 800 employees across 7 international offices serving hundreds of customers across EU. This year, we will move over 1 million truckloads, making us Europe's leading digital road freight forwarder?? pic.twitter.com/6rD7Idj2xF
— sennder (@sennderLogistic) January 14, 2021
Trucking Digital Freight Matching
KEYWORDS Sennder Uber Freight
Logixboard raises $4.2 million to digitize the $2 Trillion global Freight Forwarding industry
Cloud logistics platform FarEye raises $100 million for Amazon-like delivery
Descartes pays $12 million to acquire British digital freight platform vendor


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> Are there any good lessons on all TSNet functions?
>  I am not looking forward to wading into this blind as a bat.
> So I did not even get off home plate.
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>> I really need to get my head around TSNet, so began experiments.
>>    a    nswer "File has been downloaded"
>> # but my first attempt to "get it" ... ran into this error.
>> Are there any good lessons on all TSNet functions?
>> I am not looking forward to wading into this blind as a bat.


text:
What Goes on in a Histology Lab and What It Means for Patients
Jamie Lee Hamann
Aug 18, 2022 7:06 PM EDT
A kidney glomerulus stained with standard Hematoxylin/Eosin stain
How I Became a Certified Histologist
Prior to a historic winter, the Reno winter of 2005, I found myself unemployed. I had finished my Bachelor's in Molecular Biology, had worked as a Medical Laboratory Technician in the military, and had worked as a Phlebotomist while at school.
The city was peppered with my resume for multiple positions, from Lab Assistant to Graveyard Phlebotomist. The job market at the time seemed dead, and I quickly approached desperation.
It was at this point I found a training program being offered at Washoe Medical Center. Their lab offered a two-year training course in the field of Histology, with a promise of certification.
I had taken one course in Histology at school that had centered primarily on tissue identification. I was not familiar with the technical skills needed to perform the job when I applied and was taken in as a trainee.
Since then, I have finished my training, achieved certification, worked in a few labs, and have been active in my field for many years now. The problem with my job is that almost no one has ever heard of Histology or what it entails, and almost no one seems to be familiar at all with the role of Histology in the diagnoses and treatment of disease.
The best way I could think to describe the process of Histology is to tell the story of a patient and follow this patient from the collection of a biopsy to the diagnosis and then to any treatment given by the patient's physician.
Pancreas after autolysis and putrefaction have occurred
Well-fixed pancreas tissue without autolysis or putrefaction
Betty woke up Saturday morning and moved into the restroom to get undressed for her shower. As she undressed, something unusual caught her eye: a mole. Had that been there the night before? Where did it come from? Betty decided to call and make an appointment with a dermatologist as soon as she could.
She made the appointment and the day came to see her dermatologist. He told her that it was probably nothing but wanted to get a punch biopsy of the mole and some surrounding skin. He performed the biopsy in the patient room in minutes and sent Betty home with a small bandage.
The specimen, or punch biopsy of mole and surrounding skin, had just started its journey into the world of Histology.
The first step in specimen preparation is fixation. Fixation is described as a process that stops the tissue from going through autolysis and putrefaction and stabilizes proteins and other cellular components so that they will not change through the Histological process (Carson, 2009).
Autolysis is the action of enzymes, after the cell has died, that continue to break up cellular components and dissolve waste (Carson, 2009). Putrefaction is the action of bacteria on dead cells that cause what is called postmortem decomposition (Carson, 2009).
Fixatives will stop all enzymatic activity in the cell, put to death any bacteria living near the cell, and cause what is called a cross-linking between proteins within the cell, creating a matrix that holds the cellular components in place (Carson, 2009).
The most common fixative used is 10% formalin, which is 37% formaldehyde (a gas if 100%) diluted in water. Other fixatives are used if there are specific cellular components that need attention; for instance, a Carnoy's Fixative is used primarily for RNA, DNA, or fat (Carson, 2009).
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Betty's dermatologist took the fresh punch biopsy and placed it into a small bottle of 10% formalin to be fixed for the Histology lab. The size of the tissue determines how long the fixation, or penetration, takes. Usually only a few hours with small biopsies.
The bottle is labeled and off it went to the next step in the process.
Cassettes tissue is trimmed in for processing.
By now, Betty's mole has been packaged up and delivered to a local Histology lab for further work.
The mole was checked in at the lab, and the patient data along with billing information was logged into a computer.
At this time, the mole finds itself in a line of fellow tissue, also placed in 10% Formalin, in a grossing room ready to be grossed by a Pathologist. Grossing is when the Pathologist examines the mole and dictates into a dictation device its size, color, general appearance, and if there are any abnormalities noticeable by the naked eye. Then the Pathologist trims down the tissue, or not in the case of the mole, and places the tissue into a cassette for a procedure called processing.
The end product of Histology is to have a slide made with a thin section of tissue. The tissue, even after fixation, is still not firm enough to obtain a thin section. The only way to ensure that the tissue can be cut into such a small section is to completely impregnate the tissue with a medium that is harder.
Most tissues are impregnated with Paraffin wax to harden and to hold the cellular components still for microtomy. This is called processing the tissue and is accomplished with three steps; dehydration, clearing, and infiltration (Sheehan,1987).
Dehydration commonly uses alcohol to displace and replace the water in the tissue. Clearing commonly uses a hydrocarbon like Xylene to remove the alcohol and to "clear" the tissue or change the refractive index of the tissue so the cells can be seen through a microscope. Infiltration is the replacement of the xylene with melted paraffin wax that will harden the tissue and makes the tissue ready to be cut (Sheehan,1987).
Processing takes around twelve hours, unless a rapid process is used, and is commonly done overnight for the technician/technologist to work on the following morning.
Betty's mole was placed into a cassette by a Pathologist, her information dictated, and the cassette placed into a processor to process overnight.
Embedding occuring at embedding center
Microtome with work area
Histology begins early in the morning. Histotechnicians/Histotechnologists must be present when the process is finished to move the tissue from the processor to what is called an embedding center.
Also, the pathologist like to have their slides made when they come into work around 8:00 am.
Anyway, back to the embedding center. An embedding center is a work area that includes a hot area to keep melted paraffin wax and stainless steel molds.
The molds are filled with melted wax, and the tissue is placed properly in the mold. After the tissue is placed in the mold, the mold is placed onto a cold plate to solidify. Once the wax in the mold is solidified, the molded wax is removed from the molds and taken to a microtomy area to be cut.
The block, or the molded wax, is then faced. Facing is removing excess wax from the block and cutting into the block until a nice smooth area of tissue is available for microtomy (Carson, 2009). The faced blocks are then placed onto an ice bath. The ice bath lowers the temperature of the wax and makes it easier to obtain a thin section. An example would be trying to cut a block of warm cheese into thin slices compared to a block of cold cheese into thin slices.
Microtomy is performed on a microtome. A 3-5 micron section is collected from the microtome in the form of a ribbon. To help the reader understand how thin the section is, 3 microns is also the same thickness as a red blood cell (Carson, 2009).
A ribbon of sections is removed carefully from the microtome and placed on a water bath set to 38 degrees C. The water bath removes any wrinkles from the sections and also spreads out the tissue for the next step (Carson, 2009).
Next, a section from the ribbon is picked up on a labeled slide and placed on a rack to dry. The slide with Betty's mole is now ready to be stained.
Automated Stainer.
After the slide has dried, either on the countertop for a while or in an oven, it is placed within an automated stainer that will stain the slide with a Hematoxylin and Eosin stain.
The first step in the automated stainer is to place the slide through xylenes and a series of alchohols to remove paraffin from the tissue. Then the slide is placed in water to remove the alcohol. At this time, the tissue on the slide is ready to meet a stain (Carson, 2009).
Hematoxylin and Eosin are the most common stain and counterstain used in modern histology labs.
Hematoxylin is extracted from logwood, or Haematoxylon Campechianum, as Hematein and is oxidized into a dye (Sheehan, 1987).
When a metallic mordant is added to Hematoxylin, the dye begins to have a stong affinity for nuclei and nuclear material, making the dye a nuclear stain. Nuclear stains are positively charged and cationic, which accounts for the affinity to amino acids. Hematoxylin stains blue (Carson, 2009).
Eosin is the common counterstain to Hematoxylin and stains cell plasma components. Eosin is negatively charged and anionic, which accounts for its affinity for positively charged cell plasma proteins. Eosin stains red or pink (Carson, 2009).
Once the slide is stained, it is covered with a glass coverslip to keep the stained area safe. The slide is then ready to be looked at under a microscope and examined by a pathologist.
The labs work with Betty's mole is over, and the slide with the mole is now sent to the Pathologist to examine.
The End Product
The slide made it onto a Pathologists microscope and is examined promptly. He examines all the cells to ensure that there are no abnormal cells present. He finishes up his report and sends it to the Dermatologist that had ordered the Histology work.
Later that week, the Dermatologist's office gets the results and calls Betty to let her know that not only was she able to get a mole removed, but the mole was benign, or not cancerous.
Betty was relieved and was able to sleep well since she had the mole removed two days earlier.
I still work in the field of Histology as an Histotechnologist. I love my work, and I am proud to be a part of the medical community. There is currently a shortage in the field of Histology, and I hope that this article may excite readers to consider it as an employment possibility.
The current certification agency is ASCP, American Society of Clinical Pathologists, and the requirement for a Histotechnician is an Associate Degree in Science, and for an Histotechnologist, it's a Bachelor's Degree in Science. Both require the candidate to sit down for a certification exam.
Sheehan DC, Hrapchak BB, Theory and Practice of Histotechnology, 1987, Battelle Press.
Carson F, Histotechnology a self-instructional text, 2009, American Society of Clinical Pathology.
This content is for informational purposes only and does not substitute for formal and individualized diagnosis, prognosis, treatment, prescription, and/or dietary advice from a licensed medical professional. Do not stop or alter your current course of treatment. If pregnant or nursing, consult with a qualified provider on an individual basis. Seek immediate help if you are experiencing a medical emergency.
Erik on February 18, 2015:
You're a real deep thkrnei. Thanks for sharing.
Jamie Lee Hamann (author) from Reno NV on January 23, 2013:
It is good to me, thank you for stopping by DDE. Jamie
Devika Primić from Dubrovnik, Croatia on January 23, 2013:
You have explained in detail of what your job entails, thanks for this information, sounds like you enjoy it too
Jamie Lee Hamann (author) from Reno NV on May 25, 2012:
Thank you Charles for reading this hub and taking the time to learn a little about my career field.
Charles Hilton on March 22, 2012:
Very informative and well written. I'd heard of histology before, now I know what it actually entails.
Up and over!
Jamie Lee Hamann (author) from Reno NV on March 04, 2012:
Gut Morgen Thomas! I hope never to have to explain my job again.
ThoughtSandwiches from Reno, Nevada on March 03, 2012:
Jamie...
So this is what you do all day at work? When this first scrolled down my feed I thought it said "History" ..as you know...I got excited...then i noticed it said "Histology" and thought you would like it...then I realized you wrote it. It's been that kind of a few days I fear...
Thanks for sharing your day and adding a link to Betty! I don't know that Betty actually has any moles...she won't let me close enough to find out...
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I'm not sure if you are talking about traditional composting or vermicomposting here.
To answer your question anyway!
Vermicomposting (primarily using composting worms to turn organic waste to compost) does NOT produce heat.
Heat is generated by the bacterial activity of waste breakdown in traditional composting. As heat is generated bad bacteria is killed off, but good thermophillic (heat loving) bacteria grows and carries on producing heat until most of the waste is broken down.
With a decrease in microbial activity the temperature cools back down and ta-da, there's your compost!
There are many reasons why a traditional composter does not heat up, but the most common is not having the right carbon:nitrogen ratio which should be about 30:1.
Gardeners may throw in a lot of woody material where microbes cannot quickly get into action. Adding more nitrogen based waste (grass clippings, food waste) can greatly increase the chance of your compost getting started.
In vermicomposting, things work a little differently.
Many people think worms literally gobble up chunks of organic waste. Worms only have a small opening for a mouth, and so as well as feeding on small pieces of food, it also relies on a diet of microbes which are working on the waste matter. As worms consumes microbes, the system doesn't heat up which is good otherwise you will have a bin full of cooked worms!
Back to your other questions about holes in the bottom of the bin and adding worms to compost.
I assume this is about a traditional composting bin.
There are two types of bases for cone shaped composting bins, a solid base with perforated holes and an open base.
They are both equally good for composting.
A solid perforated base is useful if you have problems with vermin as it helps to keep them out while at the same time allowing worms and other small useful critters in the surrounding soil to come in.
It is important to allow these creepy crawlies in as they are part of the chain in the composting process, so the more holes the better. Worms not only come into the compost bin to help with waste break down but they also move out into the surrounding soil aerating it, and distributes highly nutritious worm cast.
If your surrounding soil is poor and it doesn't seem like you have many worms around, you can add some worms into the system.
Yes, they will multiply, but because your composting bin will heat up, you will not have a constant boom of worms. Instead they will move into the surrounding soil and come back when conditions are right.
All in all, your soil will benefit!


text:
Chlöe Herington // composer, performer, collaborator
SCORES & OTHER
Chloe Herington
Not one, not two....but THREE new releases on the way!
It may have appeared quiet on the release front since the VÄLVĒ cycles ep and gigs haven't been happening due to lockdown but things have been quietly ticking away. I started writing an album based on recurring dreams in about 2006 (before VÄLVĒ was active under that name) and recording began in 2010. Then life and other projects took over. But lockdown has allowed me the time (and stripped me of excuses!) to get back to work on it and it is finally at the mastering stage. Huzzah! There will be a 'soft' release and then a proper launch when lockdown restrictions ease and we can have proper gigs. It's very different to the VÄLVĒ you may have heard before (as this is actually before) and features an array of glorious sounds from musicians such as Alex Ward, Kavus Torabi and Ivan Hussey.
VÄLVĒ in its current trio form has also been busy. We are releasing a triptych created individually during lockdown called 'transmissions' which will be available on bandcamp before the end of the summer. It's lo-fi and garden based. It will be accompanied by three corresponding videos.
Work has also continued with our debut full album - recordings of songs that have so far only existed live, new material and a re-work of 'lights'. News on that to follow in due course.
Ombrelle Concrète
Autumn/winter VÄLVĒ/solo gigs & news
Collaboration with Jonathan Baldock and Florence Peake


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A long-awaited historical retrospective on the influential 1982 New York University, Music in the Life of Man. This volume contains excerpts from the original unpublished papers, photographs of symposium participants, interviews with participants about their memories of the gathering, and analysis of the continuing significance of the symposium dialogues some 35 years after the event. A thorough description of the structure and processes of the symposium offer a model of how to organize a Music Therapy gathering with depth and relevance from the perspective of past present and future. Intensive collaboration is the theme. This book helps to identify the roots of Music Therapy dialogues Internationally. The work is dedicated to those important Music Therapy pioneers who attended the symposium and have since passed away.


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text:
Jianjun Zhang, MD, PhD
Department of Thoracic-Head & Neck Med Onc, Division of Cancer Medicine
About Dr. Zhang
Dr. Zhang obtained his MD and PhD degrees in China with numerous awards for achievement from Tongji Medical University and Chinese Academy of Medical Sciences and Peking Union Medical College, respectively. Between 2002 and 2008, he completed a Research Fellowship at Memorial Sloan Kettering. His research focused on cancer genomics, molecular biomarker discovery and experimental therapeutics. Following his Clinical Internship and Residency at Long Island Jewish Medical Center, Dr. Zhang joined MD Anderson Cancer Center in 2011 as a Clinical Fellow and later as a C.G. Johnson Advanced Scholar. Currently, Dr. Zhang is an Assistant Professor in the Department of Thoracic/Head and Neck Medical Oncology with a secondary appointment at the Department of Genomic Medicine. He is a physician-scientist, specializing in lung cancer medical oncology and with a lab investigating cancer genomics and immunogenomics of lung cancer. Dr. Zhang was selected for the T32 Ruth L. Kirschstein National Research Service Award Training Grant from 2012-2014. In 2013, he received the A. Lavoy Moore Endowment Fund Award. In 2015, he was awarded an ASCO Young Investigator Award and selected for the MD Anderson Physician Scientist Program and the Khalifa Scholar Award.
Meet Jianjun Zhang, M.D., Ph.D.
Can lung cancer be stopped before it starts?
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Study helps predict lung cancer patients' response to checkpoint blockade therapy
Associate Professor, Department of Thoracic/Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Professor, Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
The focus of Dr. Zhang's laboratory is to define modifications in genes that can cause a normal cell to become a cancer cell. Dr. Zhang is particularly interested in studying tumor heterogeneity, i.e. the cellular differences between tumors (inter-tumor heterogeneity) and within a tumor (intra-tumor heterogeneity), and its impact on a patient's immune system competence, response to therapy and clinical outcome. Currently, there are no reliable biomarkers to predict which lung cancer patients are at a higher risk of relapse following surgery. Dr. Zhang's work demostrates that tumor heterogeneity is an independent prognostic factor for disease-free survival. His lab is analyzing the genetic information of tumor samples obtained from early stage and metastatic lung cancer patients and correlating it with tumor development, progression, metastasis and drug resistance. By understanding changes that happen over time, Dr. Zhang's goal is to identify factors that predict how tumors respond to surgery and/or therapy and with this improve diagnosis, staging and treatment of lung cancer patients.
Dr. Zhang is a medical oncologist dedicated to improve the diagnosis and treatment of thoracic malignancies with a focus on lung cancer and its associated precancerous diseases. His major goals are to understand the cellular mechanisms underlying resistance to treatment, and to develop new biomarkers and novel treatment strategies for lung cancer patients. He dedicates time to patient care as well as to clinical and translational research. In the era of precision medicine, Dr. Zhang's work focuses on understanding the genetic information of patients diagnosed with lung cancer in order to identify genes that can be used to select the patients that will benefit the most from different treatment approaches. He actively participates in multiple clinical trials and leads translational efforts associated with many of these trials.
2002 Cancer Institute (Hospital), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, CHN, PHD, Oncology
1997 Tongji Medical University, Wuhan, CHN, MD, Medicine
2014-2015 Research Fellowship, Cancer Genomics, The University of Texas, MD Anderson Cancer Center, Houston, TX
2011-2014 Clinical Fellowship, Hematology and Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX
2009-2011 Clinical Residency, Internal Medicine, Long Island Jewish Medical Center, New Hyde Park, NY
2008-2009 Clinical Internship, Internal Medicine, Long Island Jewish Medical Center, New Hyde Park, NY
2002-2008 Research Fellowship, Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, NY
2014 Hematology
2014 Medical Oncology
2011 Internal Medicine
Faculty, The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 2018 - Present
Skoulidis F, Byers LA, Diao L, Papadimitrakopoulou VA, Tong P, Izzo J, Behrens C, Kadara H, Parra ER, Canales JR, Zhang J, Giri U, Gudikote J, Cortez MA, Yang C, Fan Y, Peyton M, Girard L, Coombes KR, Toniatti C, Heffernan TP, Choi M, Frampton GM, Miller V, Weinstein JN, Herbst RS, Wong KK, Zhang J, Sharma P, Mills GB, Hong WK, Minna JD, Allison JP, Futreal A, Wang J, Wistuba II, Heymach JV. Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles and therapeutic vulnerabilities. Cancer Discov 5(8):860-77, 2015. e-Pub 2015. PMID: 26069186.
Zhang J, Gold KA, Lin HY, Swisher SG, Xing Y, Lee JJ, Kim ES, William WN. Relationship between tumor size and survival in non-small cell lung cancer (NSCLC): an analysis of the Surveillance, Epidemiology, and End Results (SEER) registry. J Thorac Oncol 10(4):682-690, 2015. PMID: 25590605.
Zhang J, Fujimoto J, Zhang J, Wedge DC, Song X, Zhang J, Seth S, Chow CW, Cao Y, Gumbs C, Gold KA, Kalhor N, Little L, Mahadeshwar H, Moran C, Protopopov A, Sun H, Tang J, Wu X, Ye Y, William WN, Lee JJ, Heymach JV, Hong WK, Swisher S, Wistuba II, Futreal PA. Intra-tumor Heterogeneity in Localized Lung Adenocarcinomas Delineated by Multi-region Sequencing. Science 346(6206):256-259, 2014. PMID: 25301631.
Rotolo J, Stancevic B, Zhang J, Hua G, Fuller J, Yin X, Haimovitz-Friedman A, Kim K, Qian M, Cardó-Vila M, Fuks Z, Pasqualini R, Arap W, Kolesnick R. Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. J Clin Invest 122(5):1786-90, 2012. e-Pub 2012. PMID: 22466649.
Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R. Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood 114(17):3693-706, 2009. e-Pub 2009. PMID: 19666872.
Zhang J, Zafrullah M, Yang X, Yin X, Zhang Z, Fuks Z, Kolesnick R. Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. Cancer Biol Ther 7(9):1490-1495, 2008. e-Pub 2008. PMID: 18719367.
Jin X, Zhang J, Gao Y, Ding K, Wang N, Zhou D, Jen J, Cheng S. Relationship between mitochondrial DNA mutations and clinical characteristics in human lung cancer. Mitochondrion 7(5):347-353, 2007. e-Pub 2007. PMID: 17707697.
Rotolo JA, Zhang J, Donepudi M, Lee H, Fuks Z, Kolesnick R. Caspase-dependent and -independent activation of acid sphingomyelinase signaling. J Biol Chem 280(28):26425-26434, 2005. e-Pub 2005. PMID: 15849201.
Ch'ang HJ, Maj JG, Paris F, Xing HR, Zhang J, Truman JP, Cardon-Cardo C, Haimovitz-Friedman A, Kolesnick R, Fuks Z. ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med 11(5):484-490, 2005. e-Pub 2005. PMID: 15864314.
Zhang J, Zheng S, Gao Y, Rotolo JA, Xiao Z, Li C, Cheng S. A partial allelotyping of urothelial carcinoma of bladder in the Chinese. Carcinogenesis 25(3):343-247, 2004. e-Pub 2003. PMID: 14604888.
Zheng S, Zhang J, Di X, Xiao Z, Wang D, Li C, He Z, Han N, Guo S, Cheng S, Gao Y. [Loss of heterozygosity fine mapping of chromosome 17p13 in transitional cell carcinoma of human urinary bladder]. Zhonghua Yi Xue Za Zhi 82(3):161-3, 2002. PMID: 11953150.
Zhang J, Zheng S, Fan Z, Gao Y, Di X, Wang D, Xiao Z, Li C, An Q, Cheng S. A comparison between microsatellite analysis and cytology of urine for the detection of bladder cancer. Cancer Lett 172(1):55-58, 2001. PMID: 11595129.
An Q, Dong X, Zhang J, Huang J, Li L, Cheng S, Gao Y.. Studies on inactivation of p16/CDKN2 gene in non-small-cell lung cancer. Chin Journal Cancer 20(6):591-594, 2001.
Zhang J, Fan Z, Gao Y, Xiao Z, Li C, An Q, Cheng S. Detecting bladder cancer in the Chinese by microsatellite analysis: ethnic and etiologic considerations. J Natl Cancer Inst 39(1):45-50, 2001. PMID: 11136841.
Zhang J, Gold KA, Kim E. Sorafenib in Non-Small Cell Lung Cancer. Expert Opin Investig Drugs 21(9):1417-1426, 2012. e-Pub 2012. PMID: 22725255.
Title: The molecular and immune evolution in the progression of lung neoplasia to invasive adenocarcinoma
Funding Source: NIH/NCI
Zhang Laboratory
Department of Genomic Medicine
Department of Thoracic/Head & Neck Medical Oncology


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На́джм ад-Ди́н Абу́ Хафс У́мар ибн Муха́ммад аль-Насафи́ (; , Насаф — , ), также известный как На́джм ад-Ди́н ан-Насафи́ — исламский богослов, правовед ханафитского мазхаба, хадисовед, толкователь Корана.

Биография
Его полное имя: Наджм ад-Дин Абу Хафс Умар ибн Мухаммад ибн Ахмад аль-Насафи аль-Ханафи аль-Самарканди. Родился и жил в городе Насаф (ныне г. Карши в Узбекистане), который был одним из центром исламских наук Средней Азии. Вёл аскетичный образ жизни. Ан-Насафи приобретал знания у известных богословов своего времени, среди которых были Абу Мухаммада ан-Нухи ан-Насафи, Абуль-Иусра аль-Баздави и Абу Али ан-Насафи.

Он стал известным знатоком ханафитской правовой школы, хадисов, тафсира, литературы, языка и истории. Среди его учеников был Бурхануддин аль-Маргинани (ум. 1197 г.), автор знаменитого труда по ханафитскому фикху «аль-Хидайа».

Умер 2 декабря 1142 года в Самарканде.

Труды
Имам ан-Насафи является автором около ста трактатов и книг по различным отраслям исламских наук.

 «аль-Акыда ан-Насафийя» («Символ веры») — книга, в которой собраны воедино главные и основные положения суннитского вероучения с точки зрения ханафитов. Толкования к этому труду писал шейх ад-Даввани («Мелла Джаляль») (ум. 1501 г.), имам ат-Тафтазани (ум. 1390 г.), Курсави (ум. 1812 г.), Марджани («аль-Хикма аль-балига») (ум. 1889 г.) и другие богословы. Главным источником этой книги был труд Абул-Муина ан-Насафи (ум. в 1114 г.) «Табсират ал-адилла».
 «ал-Канд фи тарих улама Самарканд» — историческое произведение;
 «Китаб фи байан мазахиб ал-мутасаввифа» («Разъяснение суфийских толков»).
 «ат-Тайсир фи ат-Тафсир» — тафсир то есть комментария к Корану
 «ан-Нажах фи шарх китаб ахбар ас-Сихах» является комментариям к Сахих аль-Бухари

Фотогалерея

Примечания

Ссылки

Ханафиты
Матуридиты
Толкователи Корана

redpajama_set_name: RedPajamaWikipedia


text:
Instructional Materials in Multiculturalism
Below are the CLN "Theme Pages" which focus on specific topics within Multiculturalism. CLN's theme pages are collections of useful Internet educational resources within a narrow curricular topic and contain links to two types of information. Students and teachers will find curricular resources (information, content...) to help them learn about this topic. In addition, there are links to instructional materials (lesson plans) which will help teachers provide instruction in this theme.
Canadian Immigration Theme Page
Countries Theme Page
GenealogyTheme Page
Masks Theme Page
General Multiculturalism Resources
Here are a number of links to other Internet resources which contain information and/or other links related to Multiculturalism. Please read our disclaimer.
Ask Asia: Instructional Resources
Their "lesson plans" selection has lesson plans related to Asia, many of which include links to related readings, images, or classroom activities. There are also instructional materials (readings, downloadable images and maps), and links to other Asian resources. Additional resources on this page include bibliographies, reviews, and resource locators.
In this year long multidisciplinary unit, intermediate students find similarities and differences between cultures and research one specific country.
Comparative Civilizations 12
Here's a curriculum guide for a grade 12 course from British Columbia that "provides students with a range of experiences and skills that facilitate their understanding of, and sensitivity to, a variety of cultures."
A lesson plan for grade 10-12 students which is designed to help students increase their awareness of lifestyles, stereotyping, sexism, racism, and cultural diversity.
Intended for students in grades 7-10, the purpose of this 10-20 day eaching unit is to increase student awareness about Cultural Diversity in Canada, including the diversity of Canada's Native People. Activities include role-playing, creative writing, critical reading, analysis of data, and Internet use.
[The] Culture Concept
This unit plan uses four activities to introduce grade 7 students to the concept of culture and to help them acquire and organize information about people and culture.
Cultures around the World
Nine teaching units from IBM in which students use Internet resources to learn more about Cultures. One unit is for grades K-2 and the other is for grades 3-5. Teacher guides are available.
Cultures of our Nation
A grade K-4 lesson plan designed to be used daily for several months of the school year. It is intended to build self-esteem and allow students to become more aware of their rich cultures.
Foreign Language and Culture
A secondary school lesson plan to show students how the "culture of a country and the language must necessarily go together. Without the cultural aspects, much of the language usage is lost in everyday life within the country."
Holiday Lesson Plans
Lin and Don Donn have put together an extensive meta-collection of links to sites with lesson plans about holidays. This page of their collection (page 2) focuses on holidays celebrated in other countries and is a good way of supporting multiculturalism.
Learning for a Sustainable Future: Classroom Activities (LSF)
"Learning for a Sustainable Future is a Pan-Canadian nonprofit organization whose mandate is to work with educators from across Canada to integrate the concepts and principles of sustainable development into the curricula at all grade levels." This set of lesson plans deals with the concepts of human rights, human liberties, multiculturalism, and discrimination and can be used at the K-12 level.
Looking at Ourselves and Others
This global education web site is offered by World Wise Schools, a project sponsored by the US Peace Corps. Its intent is to help students define culture, develop global perspectives, and challenge assumptions. Lesson plans are organized by grade level (3-5, 6-9, and 10-12) and, within each grade level, there are several lessons targeted on each of the three objectives. Lesson plans contain an estimate of class time needed, materials, a statement of objectives, step-by-step procedures, debriefing exercises, and suggestions for extending the activity.
Multicultural Stories
This teaching unit from Queen's University has about a dozen lesson plans for middle school teachers. Students learn about the cultures and regions of Canada through reading, researching, writing, discussing, and reporting. Specific topics within the unit are a student autobiography, Canadian immigrants, multiculturalism across Canada, and First Nations.
RETANET: Resources for Teaching about the Americas
A searchable database of 65 lesson plans written by and for secondary teachers which deal with Latin America. The lesson plans incorporate the study of Latin America into various subjects, including Spanish, Social Studies, Science, Math, Art andLanguage Arts. Many lessons are cross-disciplinary and some integrate the Internet into the activities.
Note: The sites listed above all have lesson plans/activities for the Multiculturalism classroom teacher. For other resources in this subject area (e.g., curricular content or theme pages), click the "previous screen" button below. Or, click here if you wish to return directly to the CLN menu which will give you access to educational resources in all of our subjects.


In order to be fair I have to say this up front, I tend to dislike satellite speakers. These little speakers do not match the performance or frequency range of a full speaker containing a tweeter, mid range and woofer. Well, at least that was my attitude when I opened the box of Hsu Research's Ventriloquist VT-12 speaker set and the matching SFT-1 sub woofer. Now, after listening to them I seriously have to reconsider my long held opinion. These speakers, when properly set up and calibrated, provided a rich, full response over the entire audible spectrum. Add to this a price under $500 and you have a winning combination. I have not seen performance and affordability combined in such a small size. For a little icing on the cake this speaker system comes out of the box ready for 6.1 matrixed audio.
Usually a reviewer does not have to go into the theory behind a speaker system but then again this is no usual set of speakers. As noted, the typical satellite speaker is not very good at reproducing the entire spectrum of audio frequencies. Most disconcerting is the failure to address the all important range between 80 – 250 Hz. This black hole of sound is addressed in a novel manner by Hsu Research. Instead of connecting the front and rear speakers directly they are channeled through the center speaker. This center speaker contains a pair of 4" by 6" woofers that can handle the frequencies ignored by the satellite sets. This arrangement also takes much of the low end burden from the sub woofer; a common occurrence with satellite set ups, the VT-12 overall, makes considerable progress in filling this sonic hole providing a full rich sound.
While the installation of the VT-12 requires a couple of extras sets of cables it is not so overly complicated as to be a problem even for the most novice of home theater enthusiasts. Instead of connecting the front speakers directly to the receiver you run the wires first to the center speaker. From there wires go out to the fronts. To make this task as painless as possible all speakers in the VT-12 set have five way, gold plated binding posts. The actual step of connecting the wires was straight forward, once you get used to the extra wires that are required. Not only are the included instructions more specific than you usually find with speakers but there is excellent on line support to help with any problems you may encounter. Many people are already familiar with this type of wiring from their sub woofer where the front speakers come off the sub instead of through a direct connection. The difference here is the woofers of the VT-12 center speaker are better suited for the 80 to 250 Hz range than a normal sub woofer.
There is a growing interest in the new Dolby EX ad DTS ES seven channel audio formats. Included with the VT-12 is an additional satellite speaker for use as a rear center channel. If you have invested in a true seven channel receiver or amp then you can just connect the rear center speaker to the appropriate terminal. If you are still in the realm of six channel audio then the VT-12 simplifies added the seventh speaker. Basically, you connect the rear center speaker between the terminals for the normal rear speaker. You can only get matrixed sound from the rear center but most currently produced EX and ES audio tracks contained the matrix information.
While the VT-12 does not come with a sub woofer Hsu Research offers a wide variety as a separate purchase. They included their STF-1 sub woofer for the purpose of this review. The set up of the sub woofer is pretty much the same as with any such speaker.
What really separates the installation of the VT-12 from other surround speaker sets is the placement of the speakers is much more critical to the quality of sound. This is where the online support offered by Hsu Research comes in, knowing that their consumers may have some problems with getting the speakers positioned just right they have a very extensive form on their web page to obtain assistance. You enter the dimensions of your room, the make and model numbers for your equipment, where the doorways are, some preferences in listening and the audio sources you have and they will get back to you in a matter of days with a detailed list of instructions.
Placement is far more critical with these speakers than any other I have come across. I noticed while testing even small variations in where the speakers are set up will alter the audio characteristics a lot. It did help to make sure that if the center speaker is on top of your television it is angled slightly down. This seemed to help with creating the simulation of the lower frequencies coming from the small front and rear speakers.
The VT-12s came with two discs to help in calibration and testing. The first is a DVD-R that includes scenes from some well known Dolby EX films including Finding Nemo, Lord of the Rings: Fellowship of the Rings and Harry Potter. There is also a music disc with some incredible orchestral pieces on it. Once I set the speakers up according to the suggestions I received from the form on the web site the performance was far better than I could have imagined. The tone was rich and full, closing my eyes I thought the speakers where far larger than they actually are. The front speakers provided the usual separation of channels, as did the rears. The STF-1 sub woofer boomed into the room shaking the floor. In this entire manufacturer provided tests performed extremely well.
One note here, when I set up the speakers using my standard calibration discs, Video Essentials and Ultimate DVD Platinum, some of the effect was lost. It is best to stick with the advice of the experts here. Since it is free and fairly fast in response there is little or no problem with this approach. It appears that a normal calibration cannot take into account the novel approach of having the lower frequencies coming exclusively from the center channel. The VT-12 is very sensitive to even slight changes in the position. This may provide some problems in the initial set up and does somewhat restrict just where in your room you can place the speakers. Thankfully the support staff at Hsu is more than willing to help out.
Next I decided to test the system against my usual list of films. I concentrated on films with noteworthy use of low frequencies in the four main speakers. One criteria I like to use are films with a nice thunderstorm. When I listened to a venerable classic, Twister, I noticed that the rolling thunder effect was lost. With normal speakers capable of reproducing the low range the thunder appeared to move around the room. With the VT-12 system it seemed to remain located in the center of the room. I also noticed this with Terminator 2 during the scene when the terminator first appears. On a standard system the lightening crackles all around you, here it seemed more centered. Considering the cost and size of the speakers most will consider this a realistic tradeoff.
One very notable aspect of this system is the all important center speaker. The dialogue was noticeably cleaner; each word was understandable and stood out from the background music and effects. Too many systems provide only the bare minimum for the center channel speaker; here you get one that faithfully reproduces the full spectrum of sound.
Finally there is the addition of the rear center channel speaker. This little speaker did an excellent job of filling in the center rear of the audio field. It is important to remember that this is not a true, discrete channel but rather it is matrixed, derived from audio information contained in the two rear channels. Practically, this is not that important at this point in time. EX and ES titles represent only a fraction of the DVD presently released. Naturally, these discs did better at producing a realistic rear center sound. The VT-12 was capable of using the information on EX and ES discs to create a very convincing audio environment. Even with standard six channel DVDs the effect produced was notable. Logistically there are some problems with getting this seventh speaker properly placed in the room. If you have your couch up against a wall the rear speaker will wind up positioned almost directly over your head.
The Hsu VT-12 is an excellent solution for those that are looking for a compact set of speakers. It beats out any speakers of similar dimensions and price. The extra consideration of such exacting placement is worth it for the performance delivered. Initially the use of the term 'ventriloquist' made me think this was just another gimmick that would be disappointing, as it turns out that assessment was thankfully not true. The design and look of these speakers is top notch. While they can not compete with true full range speakers the money you save will buy a ton of DVDs for your collection. Hsu Research provides speakers that are small in size but huge in sound. Even when you consider the sub woofer is extra the cost is well within a realistic price range, especially consider the professional sound that is created. For people with small to medium size rooms this is a must have set.


Our school values 'Be Proud, Aim High, Work Hard, Be Nice, No Excuses' are at the centre of everything we do to maximise girls' progress, develop their character and promote their emotional health and well-being.
We are an oversubscribed girls school in East London. We can offer excellent opportunities for professional development and a great working environment.
We are looking for an ambitious, committed and caring professional to join our successful Modern Languages Department.
We have an enthusiastic and friendly team of dedicated staff who can help you develop.
We can offer a great working environment, staff wellbeing and professional development.
Our GCSE examination results are consistently very good and Ofsted described our students as 'quite rightly very proud of their school and their own excellent achievements' Ofsted February 2018.
Closing date: Friday 19th April 2019.
Please apply online on the school website.


Close to 20,000 Canadians provided their thoughts about our film HORIZON 360° – A Visual Symphony of Canada. Perhaps some of the most stirring responses were the ones that elicited some patriotic sentiment, some purpose-driven pride about Canada. In a country, where a key unifying quality is rooted in appreciating everybody's differences, it is heart-stirring the level of patriotic spirit and gratitude felt across all of our audiences for Canada after our screenings.
"WOW!!!! Proud to be Canadian" Jan.


On another note, I love the fact that I live between San Francisco and Los Angeles because it's perfect for meet ups. If you are doing any summer road trips and plan on being in the San Luis Obispo area let me know! We can get wine or ice cream!
I wish I lived on the West Coast because I'd totally ask for a meet up. i'd even pay for the ice cream!
hehe, isn't she lovely? But what is motoroil flavour... it's not rainbow, is it?
I am totally coming back next year hopefully! I have doubled my luggage almost with all the fabric I have bought! Eeeep! Thanks for the meet up it was super fun!
I actually live in your neck of the woods - I'm in Santa Barbara, but I worked in Santa Maria for years (for PCPA). I was excited to see another sewist on the Central Coast on Map the Sewintists! I've been doing some work in LA recently and had the pleasure of meeting up with some LA bloggers, it's too fun to talk in real life about sewing!


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Bayern Munich II: Regionalliga
Bayern Munich II secures win in final friendly of the season
Last test before the real deal starts...
By Frank Mo Jul 10, 2022, 12:00am CEST
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Photo by Ulrich Wagner/picture alliance via Getty Images
Bayern II's final friendly of the pre-season is complete, exactly one week before the competitive season starts. It's been nearly two months since Bayern II has played a competitive game and it will be so nice to finally have some Bavarian football back after such a break. How does anyone live without football?
The game was against FC Liefering, a side in the second division of Austrian Football, and Bayern II won convincingly with a 3-1 scoreline at the final whistle. Playing against a team like that and winning is quite impressive and is sure to be a morale boost for this very young side.
Yusuf Kabadayi (x2) and Mamin Sanyang scored, though the opponents managed to grab a goal as well through Karim Konate. Overall, with two wins and a draw, this pre-season has a big success for Bayern II and the excitement continues to grow for the upcoming Regionalliga season, in which Bayern II will look to secure promotion back into the 3. Liga.
Bayern Munich vs Eintracht Frankfurt: Gamethread and Live Blog


On PT Distinction your clients can add anything to their schedule, or move any pre scheduled item if you wish to allow it.
Adding items to the schedule means your clients can easily keep you up to date with any extra training sessions or an additional activity they do in the week. This lets you know what they've done and gives an accurate timeline to look back on.
Allowing your clients to move pre scheduled items around makes things a little bit more flexible for them. For example, if they've got a training session scheduled on a Sunday and they prefer to do it on the Saturday, they can just move it with no problems.
Here's how you set it up to allow your clients to move scheduled items around, and how it all works from your clients point of view.
To allow clients to move pre scheduled items, inside your trainer portal, click on Settings. In Settings, under "Allow Clients to Move Scheduled Items", select Yes and then Save.
That is now set up so that your clients can move items in their schedule.
From the clients side they login and select "My Schedule".
Inside their schedule, they'll see what they've got to do. If a client wants to move anything in their schedule they select the item and drag and drop. If they're on mobile, they click the item and select the option to move it.
To add to their schedule clients click on Add a Note. Set the time, then title and write in any details they wish to add.
Anything clients add or move will automatically update into their schedule inside your account as well. So you can check any details inside your trainer portal.


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Israel Biden Talks with Egypt's Sissi; Israel to Allow Humanitarian Aid into Gaza
Biden Talks with Egypt's Sissi; Israel to Allow Humanitarian Aid into Gaza
Monday, May 24, 2021 at 3:52 pm | י"ג סיון תשפ"א
CAIRO (Reuters/Hamodia) -
Egyptian President Abdel Fattah al-Sisi. (Reuters/Amr Abdallah Dalsh/File Photo)
Egypt's president discussed on Monday with U.S. President Joe Biden strengthening the Gaza ceasefire, urgent humanitarian aid to Gaza and international efforts to rebuild it, the Egyptian presidency spokesman said in a statement.
President Abdel Fatah al-Sisi and Biden discussed "developments of the Palestinian cause and ways to revive the peace process after the recent developments," the spokesman added.
Meanwhile, Israeli Defense Minister Benny Gantz announced on Monday night the partial reopening of the Kerem Shalom crossing to allow humanitarian items only into the Gaza Strip.
This will enable the delivery of medical equipment, food, medicine, and fuels for the private sector beginning on Tuesday.
Kerem Shalom will however, will remain closed for export until further notice.
In addition, it was decided to allow the transfer of patients for life-saving treatments, employees of international organizations and foreign journalists through the Erez crossing starting Tuesday.
It was also decided to open the Gaza coastal fishing area to 6 nautical miles, starting Tuesday 6:00 p.m.
Planning for Shemittah
IAF Responds to Rocket, Mortar Attacks in South
Report: Israel to Allow Cement Imports Into Gaza Again
State Comptroller Slams Israeli Home-Front Preparedness
Airport Authority Says El Al Delays Not Its Fault


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educator writer
Lowell, Massachusetts, United States
Instructor Washington University, St. Louis, 1957—1960. Assistant professor Baldwin-Wallace College, Berea, Ohio, 1960—1963, Fairleigh Dickinson University, Rutherford, New Jersey, 1963—1966. Lecturer University Edinburgh, Scotland, 1966—1967. Professor Eastern Michigan University, Ypsilanti, 1967—2001. Lecturer Peking University, 2006, Zhengzhou University, 2006, Chinese University Hong Kong, 2006.
Tsung-faung Soong
Yevheniia Yaroshynska
Jiang Jiang
Guy Gilbert
Mary Shanley
George Perkins Edit Profile
George Perkins, American writer, educator. Fellow Institute for Advanced Studies in the Humanities, University Edinburgh, 1981; Senior Fulbright scholar Australia Council for International Exchange of Scholars, 1989.
Perkins, George was born on August 16, 1930 in Lowell, Massachusetts, United States. Son of George Burton Perkins and Gladys Beatrice Jones.
AB, Tufts University, Medford, Massachusetts, 1953. Master of Arts, Duke University, Durham, North Carolina, 1954. Doctor of Philosophy, Cornell University, Ithaca, New York, 1960.
Instructor Washington University, St. Louis, 1957—1960. Assistant professor Baldwin-Wallace College, Berea, Ohio, 1960—1963, Fairleigh Dickinson University, Rutherford, New Jersey, 1963—1966. Lecturer University Edinburgh, Scotland, 1966—1967.
Professor Eastern Michigan University, Ypsilanti, 1967—2001. Lecturer Peking University, 2006, Zhengzhou University, 2006, Chinese University Hong Kong, 2006.
George Perkins has been listed as a notable writer, educator by Marquis.
Travel, tennis, literature, basketball.
Married Barbara Miller Perkins, May 9, 1964. Children: Laura, Suzanne, Alison.
George Burton Perkins
Gladys Beatrice Jones
Barbara Miller Perkins
Alison Perkins
Laura Perkins
Suzanne Perkins
Tufts University , Bachelor of Arts
Duke University , Master of Arts
Cornell University , Doctor of Philosophy
Fellow Institute for Advanced Studies in the Hu Fellow Institute for Advanced Studies in the Humanities, University Edinburgh, 1981. Senior Fulbright scholar Australia Council for International Exchange of Scholars, 1989.


SUMMARY: Axel Springer newspaper uses celebrities for multi-media campaign aimed at "outing" existing readers and encouraging new ones.
Bild has by far the biggest print-run of any European newspaper and is read by more than 11 million people every day. Readers value its clarity, conciseness, and inimitable style. What appears in Bild shapes public discussion.
But many readers will not admit to reading Bild. Our challenge: to bring Bild reading out of the closet!
That's why we made a campaign that takes the famous Bild slogan, "Bild Dir Deine Meinung!" (which translates to, "Form your own opinion!") and makes it its own.
The campaign addressed Bild's weaknesses: "confessor deficit" or the lack of self-confessed Bild readers. For this reason, we targeted opinion leaders to give their thoughts on Bild.
So Bild itself thus became the subject of statements that demonstrate, in a surprisingly, uncensored and open way, what these celebrities think of Bild. Our protagonists were, and should be, completely honest and make provocative or controversial judgments.
It was especially important for non-Bild readers, and those who dismiss it outright, that we surprised them with statements from people you would not normally associate with Bild, such as the German politicians Gregor Gysi and Hans-Dietrich Genscher, or the internationally successful fashion designer Wolfgang Joop.
Some celebrity statements referred to Bild.de (as with Bill Kaulitz, the lead singer of the band Tokio Hotel).
The campaign used moving images to bring the concept fully to life. The celebrities shared their personal opinion as an individual and used the strength of the spoken word. The power of the more controversial opinions, especially, became heightened through film. The immediacy and lack of manipulation contributed in particular to conveying credibility and authenticity.
In addition, a variety of visuals were developed for print and online to represent the entire gamut of opinions about Bild. At the same time, these media enabled us to target different groups through a variety of visuals and personalities.
The campaign shifted Bild's image. It has succeeded in giving a boost to the likeability of the Bild brand.
The "confessor campaign" had presence. Its awareness rating was unusually high. In addition, the campaign has managed to appeal to both readers and non-readers in a short space of time and to incite them to both think about Bild and talk about it themselves.
The relevance and content of the campaign of statements achieved a very high recognition rating.
The campaign was fixed in people's minds and correctly attributed to Bild. In addition, the campaign has helped to stabilize Bild's market share (print), to have an impact on sales and to win new readers for Bild.de.
Daniel Kießling is account manager at JVM (Jung von Matt), based in Hamburg, Germany. He can be reached at Daniel.Kiessling@JVM.DE.


Pakistan Police force is as important as Pakistan army, navy and air force same like these forces police force also plays same role in managing law and order situations. It is our police force who make it possible that we can live in peaceful society by controlling the crime levels and negative acts by some negative people.
Police forces give equal sacrifices as our other forces but unfortunately this force has been always neglected as compared to the other forces, it have not given same respect, status, facilities, accommodations and other benefits. Due to which corruption level has been more found in this force. It is necessary to provide all facilities to everyone so he or she can live his or her life easily and brae his/her daily expenses within his salary range. Our this force needs little bit attention than it can perform more efficiently which will our city and country environment batter crime rate will be reduce and citizens will live more satisfactory and peaceful life.
For more details and guidance about jobs in Pakistan police force, Navy. PAF, army, admissions or information from any field of life visit our website you will get all details here. stay in touch with us we will update you here with more latest details about jobs in Pakistan police force 2017 and 2018.


text:
Watt Street Bus Shelter
7th of December, 2021
The parish council would like to apologise for any inconvenience caused due to works connected with the installation of a new bus shelter at the Watt St junction with Whalley Road.
When the development at Victoria Mill was approved the developer - Skipton Properties- were bound by the planning consent to pay an amount of money to LCC for the improvement of this shelter. LCC surveyed the site and the parish council agreed to a Victorian type shelter being installed- at that point a timescale for installation was not given. When works commenced to remove the old shelter last week LCC had not advised the parish council this would be occurring at this time. The parish council had been reliably informed at the time the order was made by LCC that it would be advised of the start date. Despite emails with our contact asking for progress we have never been given a start date. It transpires our LCC contact was unaware works had commenced and he is very embarrassed to learn of this from the parish council, he immediately contacted the supplier which also installs and they responded as follows:
'There was a slight delay due to unforeseen circumstances. We have re programmed the installation for this Friday.'
The parish council is continuing to pursue this and will do all it can to ensure the shelter is available for use as soon as possible.


I noticed right at the beginning of the residency month that using only the subway and walking was going to kill my feet. We thought cycling is an answer for that. I have previously done sightseeing in many cities from Kyoto to Berlin by bike and found it a nice way to get to know the city. Biking in a much larger city like New York made me a bit nervous in the beginning, even though I knew that numerous procedures done in recent years makes it easier and safer to bike in NYC nowadays.
The change into a bike-friendly environment happened thanks to Janette Sadik-Khan, a former Transportation commissioner of New York City. As she tells herself, in just two years after she started in the job, they had created a 200-mile bike lane network in NYC, doubling the existing 220 miles of bike lanes. I didn't happen without resistance. One of the hottest arguments was about bringing a bike lane to Prospect Park West. Park Slope next to Prospect Park happens to be a nice and expensive neighbourhood. Prospect Park West on the other hand didn't seem heavily trafficked at all when we went there one Friday afternoon, one of the busiest rush hours of the week. Clearly the bike lane has not been the disaster opponents were expecting, even though a former 3-lane street was transformed to a 2-laner. Actually quite the opposite has happened, since the number of accidents has decreased and traffic flow has improved, as Jeff Speck tells in his book Walkable City.
In 2008, the vehicle lanes of one of the most prominent and central streets of NYC, Broadway, were narrowed down to make room for a bike lane. Simultaneously, a series of plazas were created in the corners where diagonal Broadway meets avenues from Times Square to Union Square. In some of these plazas all motored vehicle traffic is forbidden.
In action it seemed that the bike lanes and plazas slowed the motored traffic down a bit, but at the same time speeded up cycling tremendously. The sense of safety, which I very much appreciate, was better than in most streets of Helsinki. Plazas were cozy and popular places to sit down, even though they looked temporary (on purpose). It was actually hard to imagine Broadway how it must have looked like before the change.
Plaza and a Citi Bike station along Broadway.
Subway stations are usually about ten streets or roughly one kilometer apart, and they run effectively only towards downtown both in Manhattan and Brooklyn. Luckily New York City has a Citi Bike system since 2013 and we decided to give it a try.
Citi Bike was super easy to use and we found it affordable. You can choose between a 1-day pass, a 3-day pass or a yearly membership. You find the whole station map on their website. As usually in shared bike systems, you have to return the bike within a half an hour, but you can take as many rides as you want to. Citi Bikes are apparently popular in work commuting. During rush hour and near big workplaces Citi Bike stations were sometimes empty, but otherwise there was always a bike to rent.
We explored the city by bike several times. The combination of subway and Citi Bike worked seamlessly together and we didn't have to walk in the heat any more than necessary. Manhattan traffic culture was quite forgiving towards cyclists and car traffic was so slow that fears quickly disappeared. It felt different to cycle in less central areas of Brooklyn, where driver is still clearly the king.
All in all, New York City has succeeded making cycling a real, approachable option in commuting and moving in the city. This has happened in just a few years, and the walking environment has improved a lot at the same time. We have a bike boom in Finland as well, so let's keep it growing! If change is possible in NYC, it is possible anywhere!
Our second chance to meet local planners was at my current (and Laura's former) employer, WSP – Parsons Brinckerhoff's local office in NYC. The NYC office's history has its background in Parsons Brinckerhoff, which was founded in NYC in 1884 and merged with WSP group in 2014. PB has a long history of projects in NYC, as one of their early projects was NYC's original IRT subway line which was opened in 1904. So we got a chance to visit a company whose designs we had also experienced as users during our trip.
We crossed the Newport Bridge, which is designed by Parsons Brinckerhoff.
We had a casual meeting where we exchanged ideas about current urban planning and design topics in Finland and in the US and our approaches on design. The contexts and scales vary of course, but a lot of the issues behind our assignments are the same at the moment. We both have projects dealing with freeway removal, transit oriented design, walkability and street transformations. These are of course global trends, so it is not that big of a surprise. But since this was a meeting between two units within the same company, we didn't have to market ourselves.We could also talk about our daily practice and the difficulties in it openly. And surprisingly, a lot of the everyday challenges were so similar as well!
Besides the projects, the meeting was of course about cultural exchange within a global company. When you give or see presentations abroad it is not only interesting to see what is presented, but also how it is presented. We dare to say that we are at least decent presenters by Finnish standards, but we realized there's a lot to be learned from the way US professionals present their work. They present even the every-day projects with such a confidence that many times you would expect to see something really groundbreaking, yet you don't get the feeling of exaggeration. I think it just shows that they take the project seriously and do it with pride. There is something endearing in our way of being (too) humble in Finland when we talk about our work, but a pinch of self-confidence wouldn't hurt.
WSP-PB in NYC has a great midtown location which offered us a peak into the daily office life in those busy quarters. After seeing their work environment, we also got an invitation to see their after-work environment in a nearby restaurant. While the atmosphere in the initial meeting was already laid back and welcoming, it was also nice to see the ties loosen up a bit and get to know the people a bit more.
We arrived in New York City three days ago. The city is strikingly big! We took an airport train and subway from JFK to Harlem and Laura managed to sleep for quite a bit on the way – the trip through highly urban neighbourhoods took about 1,5 hours. We are both excited and anxious about the hugeness and endless stories of the city – how much can you even cover in only one month?
Our study program for this August includes four themes: urban regeneration, transforming streetscape, waterfront development and using public space bottom-up. In all of these we are interested in interfaces of different spaces, user groups or forms of development. We try to give you some insight on these topics while comparing our observations with our daily work.


text:
The Club is committed to being active in the community by hosting events on and off the field. Partnering with Major League Baseball and local charities, the Tigers execute various player programs, support educational programs, provide scholarship opportunities and honor the different cultures in baseball.
MLB Initiatives
The Detroit Tigers and Major League Baseball have partnered with ALS (amyotrophic lateral sclerosis) organizations nationwide to raise awareness about the disease. The initiative remembers the great Lou Gehrig who inspired so many with his outstanding on-field achievements and unparalleled strength of body, mind and character. As Baseball remembers the legend, the team honors all who have been touched by ALS, the disease that came to be named after the baseball great with an on-field ceremony.
To recognize April as Autism Awareness Month, the Detroit Tigers and Major League Baseball partnered with Jack's Place for Autism, a foundation started by Tigers broadcaster Jim Price and his wife Lisa. Jack's Place for Autism was recognized during a pregame ceremony at Comerica Park, in an effort to help raise awareness of individuals impacted by Autism Spectrum Disorder.
Going to Bat Against Breast Cancer
The Detroit Tigers hosted the 2017 Major League Baseball Honorary Bat Girl, Lisa Meyer from Houghton, MI, as selected through an online contest at tigers.com to recognize inspirational fans that have been affected by breast cancer and demonstrated a commitment to the cause. Lisa was one of 30 winners selected by MLB from many entries.
The Detroit Tigers provided complimentary game tickets for Lisa and her family, access to watch batting practice from the field and the opportunity to throw the ceremonial first pitch. Lisa also received a special Honorary Bat Girl jersey and a Louisville Slugger Pink Bat engraved with her name along with other breast health awareness items.
Major League Baseball and the Detroit Tigers teamed up to "Keep Dad In The Game" by dedicating Father's Day to the fight against prostate cancer.
The Detroit Tigers partnered with the Men's Health Foundation to invite 100 prostate cancer survivors on field to be recognized in a group recognition ceremony prior to the game. Nearly 500 tickets were donated to the Men's Health Foundation for the prostate cancer survivors and their families to attend the game.
A special day is dedicated to bring awareness about childhood cancer during Pediatric Cancer Awareness Month. In the United States, childhood cancer is the leading cause of death by disease in children aged 15 and under. MLB, in partnership with Stand Up To Cancer, is committed to eradicating the diseases that these brave young people face every day. The Tigers, in partnership with the Children's Leukemia Foundation, honored 16 patients with a pregame ceremony.
PLAY BALL is a MLB initiative that aims to give kids the opportunity to enjoy the game of baseball or softball in a fun environment by highlighting the many ways baseball and softball can be played while providing memorable experiences. PLAY BALL introduces young people to the sport who otherwise may not have the chance to experience it, offering healthy and active lifestyle options. The Tigers celebrated PLAY BALL with a kids only press conference, a middle school gym takeover, a Fox Sports Detroit Jr. announcer and a pregame on field clinic.
Inside Tigers Community


AHDB works with livestock farmers to promote disease prevention methods such as vaccination, biosecurity and improved management and housing to reduce the need for antibiotics on farms by preventing and eliminating disease. We encourage professionals, such as vets, to work closely with farmers in order to best manage animal health issues and to minimise the need for all medicines. We also believe that animal welfare is paramount and therefore continue to support the use of antibiotics and other veterinary medicines where necessary.
AHDB also supports the Responsible Use of Medicines in Agriculture Alliance (RUMA) in promoting responsible and prudent use of antibiotics in livestock and in helping the industry to progress animal health matters. AHDB has helped coordinate the Targets Task Force groups for sheep and beef, which identify meaningful objectives to reduce, refine or replace antibiotic use in all livestock sectors, while also supporting the Dairy Antimicrobial Stewardship Group led by the milk buyers.
And AHDB is working on behalf of the industry to provide independent data sets on antibiotic use in livestock production to enable trends to be identified and, ultimately, usage targets to be monitored. This currently includes an eMedicines Book (eMB) for the pork industry and we are currently considering the possibility of similar options for other livestock sectors. Other examples of AHDB's extensive programmes of work to improve animal health includes the Mastitis Control Plan in the dairy sector and AHDB Beef & Lamb is also working to promote the use of vaccination policies alongside good management practices and housing design to reduce cases of respiratory disease in beef cattle.


My awesome mate, Amir, will be launching his new publication, F A R I M A N I, this Saturday, March 1st at Printed Matter from 5 – 7pm. F A R I M A N I will showcase never before published contributions from artists, musicians and theorists alike, with original works by Slavoj Zizek, Felix Guattari, Olafur Eliasson, Amir Mogharabi, Sylvia Kolbowski, Fred Frith, Ikue Mori, Caroliner and many more. F A R I M A N I is a handsome pocket-sized (4 1/8 x 6 7/8 inch) journal published on a high quality matte finished paper.
Come to JCP this Saturday (before GAG!)—I have a new painting in the show... 625 West 27th, 6–8pm. FREE BEER!!
Or, we/I thought she was. I think it's some kind of art project?? I don't know but, I love all the reactions it has gotten—read the comments—they are worth making into an art project!
Hood by Air's Fall 2008 season is a mutation of rave, goth & hip hop. There were some awesome graphics on the clothes too created by Ezra (a.k.a. KINGDOM). The dude with the long hair was super hot! Bravo $hayne, Raul & the krew at Oak for putting on a fun show!
I kant wait for "OTTO; or up with dead people!" I am soo over rampant consumerism... Bruce LaBruce's latest existential zombie flick looks totally radd! My friend Christophe Chemin is in the film and made the awesome poster for it.
Telfar's new collection is soo awesome! I made this little video at the show last night at St. Mark's Church. Fatima did the music. It was totally sci-fi. I loved it!


text:
Indonesia sees China firms lead 'commitment' for $35bn nickel investments
Reuters | October 16, 2020 | 10:40 am Battery Metals Intelligence Asia China Nickel
Jakarta, Indonesia. (Stock image)
Indonesia expects to see investment in nickel processing, as well as petrochemicals, double to $35 billion by 2033, led by investors from China seeking to expand their businesses in Southeast's biggest economy.
Chinese steel and battery companies operating in Indonesia met with the country's Coordinating Minister for Maritime and Investment Affairs Luhut Pandjaitan during his recent visit to Yunnan province, the minister's spokesman Jodi Mahardi said.
Sign Up for the Battery Metals Digest
Among the projects discussed was a plan by China's Contemporary Amperex Technology Co Ltd (CATL) and Ningbo Lygend Mining Co to create an integrated lithium battery production facility, according to Jodi, who said it would be their largest such facility in the world.
Indonesia was the largest nickel ore exporter until it stopped exports in January to ensure there were enough raw materials for investors to use in the country
The companies, along with others including Tsingshan Holding Group and Delong Holdings, currently have around $16 billion invested in Indonesia and "made a commitment" to the minister to increase their collective investment to around $20.9 billion by 2024 and to around $35 billion by 2033, said Jodi.
"They will collaborate with investors from France, Japan, South Korea, Australia and other countries," Jodi said.
The companies are planning to expand their nickel processing capacity in Indonesia, as well as investing in petrochemicals and stainless steel, he added.
CATL, Ningbo Lygend and a Tsingshan representative declined to comment, while Delong Holdings could not immediately be reached.
Indonesia, a major nickel ore producer, is keen to expand as a nickel processing hub, starting from steel, to extracting battery grade chemicals from the ore, and eventually producing batteries for electric vehicles (EVs) and building EVs.
A group of Indonesian state-owned companies are planning to form a venture to make batteries for EVs, the chief executive of Mining Industry Indonesia said this week, and the new company would partner with Chinese and Korean firms on projects valued at $12 billion.
Indonesia was the largest nickel ore exporter until it stopped exports in January to ensure there were enough raw materials for investors to use in the country.
(By Tom Allard, Fransiska Nangoy, Tom Daly and Min Zhang; Editing by Ed Davies)
More Nickel News
Appian CEO on principles for mining investment
MINING.com Editor | January 13, 2021 | 12:29 pm
Cornish Metals to float shares in London


text:
using System;
using System.Collections.Generic;
using System.Linq;
using System.Web;
using Database.Models;

namespace WCF.Repository
{
    public interface IRepository
    {
        Tamagotchi Get(int id);

        List<Tamagotchi> GetAll();

        void Delete(Tamagotchi tamagotchi);

        void Update(Tamagotchi tamagotchi);

        void Create(Tamagotchi tamagotchi);

        bool SaveChanges();
    }
}

redpajama_set_name: RedPajamaGithub


text:
Q: Original Array value after modification var a = ["11", "22", "46", "22", "11", "55"];

console.log(a); // [ '11', '22', '46', '22', '11', '55' ]

// Calculates my values
var b = a.map(function(num) {
  return num.split('')
    .map(Number)
    .reduce(function(a, b) {
      return a + b;
    });
});
console.log(b); // [ 2, 4, 10, 4, 2, 10 ]

// Finds my biggest value
var c = 0;
for (var i = 0; i  c) {
    c = b[i];
  }
}
console.log(c); // 10

// Sorts my array
var d = b;
d.sort(function(a, b) {
  return a - b;
});
console.log(d); // [ 2, 2, 4, 4, 10, 10 ]

I am having a problem here. The var d tells me about these following arrays [ 2, 2, 4, 4, 10, 10 ]. They originally come from this array ["11","22","46","22","11","55"]. I am also sorting them out. So at the end in var d I am receiving two 10s at the end of my array. Let's say that d[4] originally came from a[2] and d[5] came from a[5]. How can I make the code tell me 10's original value from my first array. Let's say we get 2, 2, 4, 4, 10, 10. I want this last 10 from right side value to tell me it came from "55". Is there a way for me to do that?

A: On your a.map, make it return an object with a property containing the original value, and a property you want modified. In the following case, original will be the value that is to be untouched while value is the one you'll be working on. Further operations should work with value and preserve original.
a.map(function(num) {
  return {
    original: num,
    value: //stuff
  };
});

A: While the other solution from Joseph the Dreamer points to the right direction, lacks it the concrete wanted result of the question.
This proposal uses an array with objects and keeps the former sort order with pos and the wanted cobined number.
After sorting, you can access the last element and get the original value from the new array.

var a = ["11", "22", "46", "22", "11", "55"],
    b = a.map(function (aa, i) {
        return {
            value: aa,
            pos: i,
            number: aa.split('').map(Number).reduce(function (a, b) { return a + b }, 0),
        };
    });

b.sort(function (a, b) {
    return a.number - b.number;
});

document.write(b[b.length - 1].value);
document.write('
' + JSON.stringify(b, 0, 4) + '
');

function myfun(a) {
    var b = a.map(function (aa, i) {
            return {
                value: aa,
                pos: i,
                number: aa.replace(/-/g, '').split('').map(Number).reduce(function (a, b) { return a + b }, 0),
            };
        });

    b.sort(function (a, b) {
        return a.number - b.number;
    });
    return b;
}

document.write('
' + JSON.stringify(myfun(['1-2-3-4', '5-67-7-8', '2-3545-4-6-8-1', '3-3-4-1-3-4', "3-2-4-5-7", '2-3-4-5-7']), 0, 4) + '
');

redpajama_set_name: RedPajamaStackExchange