Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A : Implications for Protein Deacylase Drug Development.
In: Journal of Medicinal Chemistry. (15 November 2018) .
Pharmacological modulation of the CO₂/HCO₃⁻/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.
In: Pharmacology & Therapeutics. Vol. 190 (October 2018) . - pp. 173-186.
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
In: Cell Death & Disease. Vol. 9 (24 September 2018) Issue 10 . - p. 996.
Potent and Selective Inhibitors of Human Sirtuin 5.
In: Journal of Medicinal Chemistry. Vol. 61 (12 March 2018) Issue 6 . - pp. 2460-2471.
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.
In: Nature Communications. Vol. 8 (15 November 2017) . - Article number 1513 (13 Seiten).
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
In: Proceedings of the National Academy of Sciences of the United States of America. Vol. 114 (6 June 2017) Issue 23 . - E4676-E4685.
Synthetic Glycoforms Reveal Carbohydrate-Dependent Bioactivity of Human Saposin D.
In: Angewandte Chemie International Edition. Vol. 56 (2 June 2017) Issue 19 . - pp. 5252-5257.
Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
In: PLoS Biology. Vol. 15 (5 April 2017) Issue 4 . - e1002601.
A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.
In: Science. Vol. 355 (24 March 2017) Issue 6331 . - pp. 1312-1317.
Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2 : Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
In: Journal of Medicinal Chemistry. Vol. 60 (23 March 2017) Issue 6 . - pp. 2344-2360.
Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.
In: Journal of Medicinal Chemistry. Vol. 60 (9 March 2017) Issue 5 . - pp. 1928-1945.
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
In: PLoS Biology. Vol. 15 (3 March 2017) Issue 3 . - e2000374.
In: Angewandte Chemie International Edition. Vol. 56 (19 January 2017) Issue 4 . - pp. 1007-1011.
In: Molecular and Cellular Endocrinology. Vol. 458 (2017) . - pp. 57-67.
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.
In: Nature Chemical Biology. Vol. 12 (October 2016) Issue 10 . - pp. 838-844.
Using mitochondrial sirtuins as drug targets : disease implications and available compounds.
In: Cellular and Molecular Life Sciences : CMLS. Vol. 73 (August 2016) Issue 15 . - pp. 2871-2896.
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
In: Cell Chemical Biology. Vol. 23 (21 July 2016) Issue 7 . - pp. 849-861.
Bithionol potently inhibits human soluble adenylyl cyclase through binding to the allosteric activator site.
In: The Journal of Biological Chemistry. Vol. 291 (9 March 2016) . - pp. 9776-9784.
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.
In: Journal of Medicinal Chemistry. Vol. 59 (5 January 2016) Issue 4 . - pp. 1471-1491.
In: Scientific Reports. Vol. 6 (2016) . - p. 22643.
Recombinant Preparation, Biochemical Analysis, and Structure Determination of Sirtuin Family Histone/Protein Deacylases.
In: Methods in Enzymology. Vol. 573 (2016) . - pp. 183-208.
The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters.
In: ChemBioChem. Vol. 16 (November 2015) Issue 16 . - pp. 2337-2347.
New insights into the structure and mechanism of iodothyronine deiodinases.
In: Journal of Molecular Endocrinology. Vol. 56 (21 September 2015) Issue 2 . - R37-R52.
Thyroid hormones - From Crystal Packing to Activity to Reactivity.
In: Angewandte Chemie International Edition. (11 September 2015) .
A Novel Continuous Assay for the Deacylase Sirtuin 5 and Other Deacetylases.
In: Journal of Medicinal Chemistry. (8 September 2015) .
The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.
In: ChemMedChem. Vol. 10 (January 2015) Issue 1 . - pp. 69-82.
Proteinase K improves quantitative acylation studies.
In: Proteomics. Vol. 15 (January 2015) Issue 1 . - pp. 44-47.
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
In: Nature Communications. Vol. 6 (2015) . - p. 6263.
Structure, mechanism, and regulation of soluble adenylyl cyclases : similarities and differences to transmembrane adenylyl cyclases.
In: Biochimica et Biophysica Acta : Molecular Basis of Disease. Vol. 1842 (December 2014) Issue 12 . - pp. 2535-2547.
Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution.
In: The FEBS Journal. Vol. 281 (September 2014) Issue 18 . - pp. 4151-4164.
New assays and approaches for discovery and design of Sirtuin modulators.
In: Expert Opinion on Drug Discovery. Vol. 9 (February 2014) Issue 2 . - pp. 183-199.
Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism.
In: Acta Crystallographica Section D. Vol. 69 (August 2013) Issue 8 . - pp. 1423-1432.
SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase.
In: Molecular Cell. Vol. 50 (6 June 2013) Issue 5 . - pp. 686-698.
In: Bioscience Reports. Vol. 33 (2013) Issue 3 . - pp. 395-404.
Identification of a haem domain in human soluble adenylate cyclase.
In: Bioscience Reports. Vol. 32 (October 2012) Issue 5 . - pp. 491-499.
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.
In: Journal of Molecular Biology. Vol. 416 (17 February 2012) Issue 2 . - pp. 271-286.
A molecular mechanism for direct sirtuin activation by resveratrol.
In: PLoS One. Vol. 7 (2012) Issue 11 . - e49761.
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.
In: PLoS One. Vol. 7 (2012) Issue 9 . - e45098.
Structures, substrates, and regulators of Mammalian sirtuins : opportunities and challenges for drug development.
In: Frontiers in Pharmacology. Vol. 3 (2012) Issue 16 . - p. 16.
In: The Journal of Biological Chemistry. Vol. 286 (2 September 2011) Issue 35 . - pp. 30423-30432.
Structure-based development of novel sirtuin inhibitors.
In: Aging. Vol. 3 (September 2011) Issue 9 . - pp. 852-872.
Crystal structure of the GAF-B domain from human phosphodiesterase 5.
In: Proteins. Vol. 79 (May 2011) Issue 5 . - pp. 1682-1687.
Emerging mitochondrial signaling mechanisms in physiology, aging processes, and as drug targets.
In: Experimental Gerontology. Vol. 46 (2011) Issue 2-3 . - pp. 174-177.
The mitochondrial apoptosis pathway and p66Shc : a regulatory redox enzyme or an adapter protein snuggling around?
In: Cell Cycle. Vol. 9 (15 November 2010) Issue 22 . - pp. 4425-4426.
The Lifespan-Regulator p66Shc in mitochondria : redox enzyme or redox sensor?
In: Antioxidants & Redox Signaling. Vol. 13 (1 November 2010) Issue 9 . - pp. 1417-1428.
Dietary restriction : standing up for sirtuins.
In: Science. Vol. 329 (27 August 2010) Issue 5995 . - pp. 1012-1013.
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia.
In: Biochimica et Biophysica Acta : Proteins and proteomics. Vol. 1804 (August 2010) Issue 8 . - pp. 1658-1665.
CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans.
In: PLoS Pathogens. Vol. 6 (2010) Issue 11 . - e1001193.
Carbonic anhydrase inhibitors : Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
In: Bioorganic & Medicinal Chemistry. Vol. 17 (1 July 2009) Issue 13 . - pp. 4503-4509.
Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc.
In: Aging. Vol. 1 (February 2009) Issue 2 . - pp. 254-265.
Structure and inhibition of the CO2-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.
In: Journal of Molecular Biology. Vol. 385 (30 January 2009) Issue 4 . - pp. 1207-1220.
Crystal structure of the guanylyl cyclase Cya2.
In: Proceedings of the National Academy of Sciences of the United States of America. Vol. 105 (14 October 2008) Issue 41 . - pp. 15720-15725.
In: Journal of Molecular Biology. Vol. 382 (10 October 2008) Issue 3 . - pp. 790-801.
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
In: Bioorganic & Medicinal Chemistry Letters. Vol. 18 (15 September 2008) Issue 18 . - pp. 5066-5070.
Human metastasis regulator protein H-prune is a short-chain exopolyphosphatase.
In: Biochemistry. Vol. 47 (9 September 2008) Issue 36 . - pp. 9707-9713.
Structure-based development of novel adenylyl cyclase inhibitors.
In: Journal of Medicinal Chemistry. Vol. 51 (14 August 2008) Issue 15 . - pp. 4456-4464.
Activation of the lifespan regulator p66Shc through reversible disulfide bond formation.
In: Proceedings of the National Academy of Sciences of the United States of America. Vol. 105 (15 April 2008) Issue 15 . - pp. 5705-5709.
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility.
In: Oncogene. Vol. 27 (20 March 2008) Issue 13 . - pp. 1853-1864.
Domain mapping on the human metastasis regulator protein h-Prune reveals a C-terminal dimerization domain.
In: Biochemical Journal. Vol. 407 (15 October 2007) Issue 2 . - pp. 199-205.
Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array : evidence for a second binding site on monomeric actin.
In: Journal of Molecular Biology. Vol. 366 (23 February 2007) Issue 3 . - pp. 745-755.
Molecular details of cAMP generation in mammalian cells : a tale of two systems.
In: Journal of Molecular Biology. Vol. 362 (29 September 2006) Issue 4 . - pp. 623-639.
In: Eukaryotic Cell. Vol. 5 (January 2006) Issue 1 . - pp. 103-111.
A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen.
In: The Journal of Biological Chemistry. Vol. 280 (9 September 2005) Issue 36 . - pp. 31754-31759.
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment.
In: Nature Structural & Molecular Biology. Vol. 12 (January 2005) Issue 1 . - pp. 32-37.
Crystal structure of the putative adapter protein MTH1859.
In: Journal of Structural Biology. Vol. 148 (November 2004) Issue 2 . - pp. 251-256.
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization.
In: Journal of Molecular Biology. Vol. 328 (16 May 2003) Issue 5 . - pp. 985-994.
Determinants of enzymatic specificity in the Cys-Met-metabolism PLP-dependent enzymes family: crystal structure of cystathionine gamma-lyase from yeast and intrafamiliar structure comparison.
In: Biological Chemistry. Vol. 384 (March 2003) Issue 3 . - pp. 373-386.
Mutational analyses of the p35-caspase interaction. A bowstring kinetic model of caspase inhibition by p35.
In: The Journal of Biological Chemistry. Vol. 278 (14 February 2003) Issue 7 . - pp. 5455-5461.
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.
In: Metabolism. Vol. 51 (August 2002) Issue 8 . - pp. 981-988.
Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?
In: Human Molecular Genetics. Vol. 11 (1 January 2002) Issue 1 . - pp. 93-105.
Crystal structure of transcription factor MalT domain III: a novel helix repeat fold implicated in regulated oligomerization.
In: Structure. Vol. 9 (November 2001) Issue 11 . - pp. 1051-1060.
In: Journal of Molecular Biology. Vol. 311 (24 August 2001) Issue 4 . - pp. 789-801.
Contributions of the individual domains in human La protein to its RNA 3'-end binding activity.
In: The Journal of Biological Chemistry. Vol. 276 (20 July 2001) Issue 29 . - pp. 27188-27196.
Crystal structure of paprika ferredoxin-NADP+ reductase. Implications for the electron transfer pathway.
In: The Journal of Biological Chemistry. Vol. 276 (23 March 2001) Issue 12 . - pp. 9253-9263.
In: Biochemistry. Vol. 39 (11 July 2000) Issue 27 . - pp. 7910-7919.
In: Proceedings of the National Academy of Sciences of the United States of America. Vol. 97 (11 April 2000) Issue 8 . - pp. 3856-3861.
X-ray structure of MalY from Escherichia coli: a pyridoxal 5'-phosphate-dependent enzyme acting as a modulator in mal gene expression.
In: The EMBO Journal. Vol. 19 (1 March 2000) Issue 5 . - pp. 831-842.
A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors.
In: Molecular microbiology. Vol. 35 (February 2000) Issue 4 . - pp. 765-776.
In: Biological Chemistry. Vol. 380 (October 1999) Issue 10 . - pp. 1237-1242.
In: Journal of Molecular Biology. Vol. 290 (30 July 1999) Issue 5 . - pp. 983-996.
Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration.
In: The Journal of Biological Chemistry. Vol. 274 (30 April 1999) Issue 18 . - pp. 12675-12684.
Construction and characterization of the direct piezoelectric immunosensor for atrazine operating in solution.
In: Biosensors and Bioelectronics. Vol. 12 (1997) Issue 1 . - pp. 19-27.
Structural rearrangements on HIV-1 Tat (32-72) TAR complex formation.
In: FEBS Letters. Vol. 384 (22 April 1996) Issue 3 . - pp. 255-259.
Compilation of tRNA sequences and sequences of tRNA genes.
In: Nucleic Acids Research. Vol. 24 (1 January 1996) Issue 1 . - pp. 68-72.
Crystallographic studies on carbonic anhydrases from fungal pathogens for structure-assisted drug development.
This list was generated on Fri Apr 19 08:50:52 2019 CEST.


text:
Dungeons & Dragons Online Forums > Focused Discussions & Feedback > Suggestions & Ideas > Voice statements for non-microphone players
View Full Version : Voice statements for non-microphone players
Angelus_dead
Repeating a perennially good suggestion from before DDO was launched. Note that many multiplayer action games implement this idea almost exactly (the Battlefield 1942 series, for example). For various reasons, not everyone can use a microphone at all times. The ability to make a small number of audible statements with keystrokes or mouse clicks would be a big help. Here's an example of one way to do it.
1. Get a few actors to record short speech samples. Because these may be heard in every dungeon, they'll need to be higher-quality work than some of the recent DM narration has been.
2. Players can select the voice set for each character in the options menu, constrained by race and gender.
3. A keybind opens the voice statement menu. Capslock or tilde could be a good default.
4. When the voice menu is open, pressing keys from 1-0 either plays a voice sample, or opens another menu.
5. Here are some useful voice statements and their number assignments. Notice that they are generally in opposing pairs, so they're easier for players to learn.
Main List: 1 Yes, 2 No, 3 Go, 4 Stop, 5 Help, 6 Done, 7 Attack, 8 Retreat, 9 Trap, 0 Secondaries
Secondary List: 1 Enemy, 2 Goal, 3 Where?, 4 Follow Me, 5 Great, 6 Oh No, 7 Thanks, 8 Oops, 9 Hello, 0 Goodbye
6. Optionally these messages can also show up in the text chat log, for the benefit of players who have sound off. They could also cause a small highlight on the player's map blip or character name.
7. For better results, limit the rate of sending these statements to avoid stuck-key situations and similar problems. For example, you have 4 charges of voice statements which regenerate one per 30 seconds, or faster when you have zero.
8. For profitability, create "premium" voice schemes for sale in the DDO Store that sound more distinctive (and impressive) than the default ones.
Xaearth
My recently run over by a vacuum cleaner headset says /signed. :(
Ninetoes
I would pay 20000000000.03 TP's to be able to have, on-demand, a voice clip of Dave Arneson saying "That didn't work, pull the other lever!" in that hillarious, monotone voice he uses for NPC voices in Thernal.
donfilibuster
Orratti
I'd swear they do that on purpose.
Oh, I forgot "Wait" and "Ready". They should be stuffed in there too... And of course there's gotta be "HEAL ME"
oberon131313
I like this. I also think that since we are using a hotkey to open the menu, having the options dragable to the hotbars, similar to how teleport options can be dragged, would make this system even easier to use.
I also like the limit with regen, as that will prevent griefing through the use of this system.
Razcar
Marvellous idea. Would be a great addition to the game.
SirAggravator
I liked the idea for hotkeys for different commonly used phrases.
CoX had this and one of the keys was Battlecry which you could set e.g. "Evil doers beware!"
Often I'd end up hitting the wrong key though and get "Stop" , "Yes" , and all my commands muddled :/
I personally wouldn't like the audible voice thingy as I think it will get messy and then you
may miss who said what if the voices are limited to a few sound sets. I'd end up reading the party chat
just to confirm (which I don't mind doing anyway).
Trillea
No, for one reason...
Could you imagine the mayhem if one of the clips added was "Share plz"
:eek::p
QuantumFX
Because these may be heard in every dungeon, they'll need to be higher-quality work than some of the recent DM narration has been.
WRONG! Some of us WANT to have a gameshow host ingame voice! Or at the very least people want the VERY distinctive "Somebody help me! PLEASSSSEEE!" available for female warforged that need a heal/repair.
katana_one
As a non-mic player, I find the idea interesting. Since my main is a ranger/rogue I can see myself getting a lot of use out of the "TRAP! Oh my god didn't you hear me don't run forward yet you idiot wow that has to hurt!" sound bite.
manumase
get Jo Brand and Stephen Fry for it (stephen fry voiced reaver in fable 2 (amazing how i know that and hate fable and elder scrolls), and jo brand maybe someone just us british that are sad enough to watch QI to know), maybe alan davies for characters starting under 10 int ^^ (yeh i love QI too much)
nah i agree with the idea of signing, i cant have a mic with where i live, (would just get broken by other people)
/signed
Unfortunately open to abuse with spam spam yes spam no no spam yes spamming. Do you really want some noob spamming 'heal me' x100 while you let their gimp ass die? :)
To add to the suggestions, I would love to be able to create macros/bind the existing commands!
The game currently have some good emotes such as /point and /stop, though are difficult to type in quick enough. Being able to bind some of these to a key would make them immensely more useful. Those who are more social naturally will love the extra expressiveness that you get with all the other fun ones you have.
The /alias command does not cut it, and most of the guts for this already seems to be in chat system already.
If we could bind keys to pre-defined emotes, macros, or canned text, then I would be glad.
Tumarek
... Stephen Fry ...
He would be awesome... just listened to an Audiobook read by him. But he probably is a very pricey speaker :(
/signed by the way. Would love my dwarf to be able to shout at those lazy ass elfes :)
CSFurious
i have a mic but it is not a headset so i often do not bother to use it
being able to hit a key in the middle of play would be a great addition to my gameplay
+1 rep
As opposed to them yelling it in voice chat instead?
Unfortunately open to abuse with spam spam yes spam no no spam yes spamming.
Did you actually read the suggestion?
Lordress
A good idea, and many would benefit from it. Hope it comes to light. If nothing else, at least just a "Trap, don't move" key. Nothing against those who can't/don't use voice, but a rogue who has to type trap and wait for the rest of the group to read/see it..well, it's fun to say the least. *laughs*
This in some form, would be great.
~Chopstix, Vodkka, Colleena, and Holychet~
BalanceFx
things like trap!!! Wait up, let's move, there's a fire reaver in the library! Etc. Would be most awesome
Shaamis
Umm............
You DO know he is no longer on this Plane of Existence. ........right?
stainer
A "Oh, here is that shard you were looking for. It is in mah pack. Lolz" option would be great too!
I can only get behind this if we use the Diablo II voice clips.
This is yours.
This is for you.
Time to die!
Umm......
You DO know that he already recorded that Particular Audio Clip and it's in game already in Threnal. ...............right?
Tejoncito
Nice idea, it can be better if we can have specific audio clips for specific dungeons like:
Tempest Spine: Who got the runes??!!
Necro III: Dont kill the silver flame!!!
Gwylans Stand: That chest has TRAPS...
FauxSho
<Flashback to Savage and Savage2>
/Arnold voice
"You're mine now!"
"Let me talk to your mother."
</Flashback>
/Akbar voice
"It's a trap!"
"It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!" "It's a trap!"
/squelch
ArichValtrahn
Left 4 Dead has this feature. It can be handy but people spam the **** out of it in that game. Of course, we have easy squelches here so I dont see that as a problem.
Tharlak
rimble
Yeah, I like. I only really used something like this way back in the day when I was into Counter-Strike, but even in a crazy fast-paced game like that you get really good at banging out the voice commands real quick. z-1-4 (or whatever), doesn't even take a full second.
Mockduck
Yes, I enjoy laughing maniacally in LFD to the point that people wonder what's wrong w/ me...
Still, I was just going to say that this kind of easy system of "stop!" "wait!" "trap!" and such might be perfect for DDO.
DoctorWhofan
I would add "standby for further intsruction" SO people will stop and wait for stradagy to be typed out. My biggest problem I have in TS runs.
Deathseeker
Another great idea A_D..../signed.
Let me suggest a third row of commonly needed phrases...
1. "Remove your damn curse so I can heal you"
2. "Is anyone else getting lag?"
3. "Haste would be nice" (auto speaks every 3 min)
4. "brb wife aggro"
5. "have to log, wife aggro"
6. "Check out my backstab damage on this portal!"
7. Shroud specific - "Is he dead yet? Im still showing him at 90% health"
8. "Someone rez the rogue"
9. "Everyone let the caster drop firewall, we'll stay back until the quest is complete"
10. "That's what she said"
You need the "Trap!" one, the "TRAP!!", the "TRAAAP!!!" and the "TRAP TRAP TRAP TRAP!!!!11".
I vote for the phrase "I need to buy a mike"
Arlith
Absolutely!! This is just what we need. the noob barbarian running ahead of the party, around the corner spamming the "hjeal me" key.
Sweetsoul86
I think a lot of you that are talking about it being a spam problem seem to have missed this part of the OP which is actually a great idea. I use a mic but on occasions where my neck is bothering me and I don't want to wear my huge headset I just don't talk because for the most part typing while I try to heal really doesn't help anyone.
Borror0
I think a lot of you that are talking about it being a spam problem seem to have missed this part of the OP which is actually a great idea.
Even if that was not part of his suggestion "spamming" voice chat is already possible: you just hold push to talk and spout nonsense continually.
It's not like it would create a new problem or like there was not already a solution to it (ie /ignore).
You mean. "HJEEL MEEE" of course.
Therilith
Need a dispenser here!
Jerevon
I like this. I'd like to be bale to create my own sound files and upload them.

redpajama_set_name: RedPajamaCommonCrawl


text:
package com.defano.hypertalk.ast.model.specifier;

import com.defano.hypertalk.ast.model.enums.Owner;
import com.defano.hypertalk.ast.model.enums.PartType;
import com.defano.hypertalk.exception.HtNoSuchPartException;
import com.defano.wyldcard.part.card.CardModel;
import com.defano.wyldcard.part.finder.FindInCollectionSpecifier;
import com.defano.wyldcard.part.model.PartModel;
import com.defano.wyldcard.runtime.ExecutionContext;

import java.util.List;
import java.util.stream.Collectors;

/**
 * Specifies a button, field, card or background part by cardinal number. For example, 'card 14' or 'button 2'
 */
public class PartNumberSpecifier implements FindInCollectionSpecifier {

    private final PartType type;
    private final Owner layer;
    private final int number;
    private final boolean marked;

    public PartNumberSpecifier(Owner layer, PartType type, int number, boolean marked) {
        this.layer = layer;
        this.number = number;
        this.type = type;
        this.marked = marked;

        if (marked && type != PartType.CARD) {
            throw new IllegalStateException("Bug! Can only find marked cards; other parts disallowed.");
        }
    }

    @Override
    public PartModel findInCollection(ExecutionContext context, List<PartModel> parts) throws HtNoSuchPartException {
        List<PartModel> foundParts = parts.stream()
                .filter(p -> getType() == null || p.getType() == getType())
                .filter(p -> getOwner() == null || p.getOwner() == getOwner())
                .filter(p -> !marked || ( ((CardModel) p).isMarked(context) || p.equals(context.getCurrentCard().getPartModel())))
                .collect(Collectors.toList());

        int partIndex = (int) getValue() - 1;

        if (partIndex >= foundParts.size() || partIndex < 0) {
            throw new HtNoSuchPartException("No " + getHyperTalkIdentifier(context) + " found.");
        } else {
            return foundParts.get(partIndex);
        }
    }

    @Override
    public Object getValue() {
        return number;
    }

    @Override
    public Owner getOwner() {
        return layer;
    }

    @Override
    public PartType getType() {
        return type;
    }

    @Override
    public String getHyperTalkIdentifier(ExecutionContext context) {
        if (layer == null) {
            return type.toString().toLowerCase() + " " + number;
        } else if (type == null) {
            return getOwner().name().toLowerCase() + " part " + number;
        } else {
            return getOwner().name().toLowerCase() + " " + type.toString().toLowerCase() + " " + number;
        }
    }

    @Override
    public String toString() {
        return "PartNumberSpecifier{" +
                "type=" + type +
                ", layer=" + layer +
                ", number=" + number +
                '}';
    }

    @Override
    public boolean equals(Object o) {
        if (this == o) return true;
        if (o == null || getClass() != o.getClass()) return false;

        PartNumberSpecifier that = (PartNumberSpecifier) o;

        if (number != that.number) return false;
        if (type != that.type) return false;
        return layer == that.layer;
    }

    @Override
    public int hashCode() {
        int result = type != null ? type.hashCode() : 0;
        result = 31 * result + (layer != null ? layer.hashCode() : 0);
        result = 31 * result + number;
        return result;
    }
}

redpajama_set_name: RedPajamaGithub


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Department of Dance Receives Gift for Student Scholarships and Artistic Performances
KENNESAW, Ga. (Jun 15, 2020) — Kennesaw State University Department of Dance has received a donation of $541,000 from the Yunek family.
The Eleo Pomare–Glenn Conner Dance Endowment will be used to begin the KSU Choreographic Residency Program to bring two nationally curated choreographers to the Department of Dance to create two world premieres, beginning next summer. The annual choreographic residency honors the late benefactors who were luminaries of the dance world.
The gift from Jay and Debra Yunek, the Eleo Pomare–Glenn Conner Dance Endowment, honors their late uncle, Glenn Conner, and his partner and choreographer Eleo Pomare. Pomare, who passed away in 2008, was known for developing innovative choreography that deals with social inequality and injustice. The funds will be used to promote and preserve Pomare's legacy through the cultivation of new choreographic voices. Ivan Pulinkala, dean of the College of the Arts and the founder of KSU Dance, announced the major gift at the opening of the student dance performance "Slang" at the KSU Dance Theater in Marietta.
"We are grateful to the Yunek's for their generous donation to KSU Dance in honor of Glenn and Eleo," said Pulinkala. "The KSU Choreographic Residency will help support the careers of emerging choreographers nationally and give our students a unique experience of collaborating with professionals in the field."
Combined with a previous gift received in 2018, the Yunek family has given almost $1 million to support dance at KSU.
Through the generosity of the Yunek family, emerging choreographers will have the opportunity to develop their unique artistic voice. The KSU Choreographic Residency Program will provide each chosen choreographer with a $6,000 honorarium to support their housing, travel and living expenses during the four-week residency and performance, as well as a budget to produce an original choreographic work.
KSU Dance will create a summer course in which students accepted by audition will have the opportunity to work with one of the nationally curated choreographers. Both works will be produced at the end of the summer in the state-of-the-art KSU Dance Theater, allowing the choreographer to premiere his or her work and create a promotional video for future commissioning purposes.
A screening committee of university and community professionals will annually review the work of emerging choreographers from a national pool of applicants to select two individuals for the four-week KSU Choreographic Residency Program.
Kennesaw State University Magazine
Theatre and Performance Studies professor receives award for innovative research work
Scholarship Endowment Established in Honor of Late KSU Alumnus


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Godrej retail brand India Circus eyes Rs 300 crore revenue in FY20
Godrej & Boyce's retail brand India Circus is expecting nearly 10 times growth, to clock a revenue of Rs 300 crore by 2020, a top official said Tuesday. "Our current revenue is Rs 35 crore and we are working towards achieving a Rs 300 crore revenue by 2020 and Rs 700 crore by 2025
The investment being put into the India Circus business by Godrej Interio is upwards of Rs 50-100 crore annually. Mehta said the company is planning to grow its online and offline businesses at a rapid pace to drive the growth.
Godrej Industries Q3 PAT jumps over two-fold to Rs 121.28 crore
Godrej Locks aims to be a Rs 1000-cr company by FY22
Lalit Hotels, Godrej rank among 32 multinationals to endorse UN's LGBTI standards at work
GST effect: Pay more to buy home appliances from today
Weekend Online Deals: Flipkart, Amazon offers heavy discounts on ACs, refrigerators, others
Godrej & Boyce's retail brand India Circus is expecting nearly 10 times growth, to clock a revenue of Rs 300 crore by 2020, a top official said Tuesday. "Our current revenue is Rs 35 crore and we are working towards achieving a Rs 300 crore revenue by 2020 and Rs 700 crore by 2025," India Circus founder and Executive Director Krsnaa Mehta told PTI. The home decor, design and lifestyle brand India Circus was launched as a private label in 2012 by Mehta. Godrej acquired the business in two phases, first picked up 51 per cent stake in December 2015 and then in September 2018 acquired 100 per cent, to draft it in the portfolio of Godrej Interio.
The investment being put into the India Circus business by Godrej Interio is upwards of Rs 50-100 crore annually. Mehta said the company is planning to grow its online and offline businesses at a rapid pace to drive the growth. Its online business contributes 60 per cent and offline adds 40 per cent. "Currently we have 5 stores in total, 2 in Mumbai, 1 each in Chennai, Bengaluru and Kolkata. We are looking at a company owned, the company operated and franchise model to expand our presence across cities. Our aim is to have 40 stores by 2020, which is almost over 1 store per month," he said, adding that the company delivers to 10,000 pincodes across the country.
Each offline store requires a minimum investment of at least Rs 50-60 lakh, he added. It is also looking at deepening its presence in the international market.
"We have retailed in Mauritius, Singapore and Qatar (National Museum of Qatar) and are also selling in the European continent via the Westwing Group, which is a Euro 254 million group in the continent. We will be globally accessible online to our entire consumer base and global offline stores are definitely a part of our 5-year-plan... We are also looking at being globally accessible by 2020 with stores in London, Hong Kong, New York City and many more," he said.
India Circus licenses its designs to Future Group, Bombay Dyeing, Clay Craft India and Marshalls Wallcovering and its licensed designs/products are retailed out of all outlets and multi-brand outlets of these brands. "Licensing and royalties is one of the clearest whitespace for us. We want omni-channel presence. Currently we are looking at market places and premium partnerships with online players like Amazon, Myntra, Jabong, Pepperfry and other players in the space," he said. He further said the company sees a huge demand in corporate gifting, making it an inorganic growth opportunity.
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KTS Grill Cleaner will be here in Mid_June!!!
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Mobile phones and wireless networks (wi-fi) may be convenient but brain cancer isn't. Exposure to microwave radiation at cell phone and wi-fi levels causes irreversible DNA damage that can lead to cancer. Now that you know, what will you do?
While drinking cow's milk increases the risk of cancer, heart disease, osteoporosis and host of other illnesses, low-fat and nonfat milk consumption specifically increases the risk of prostate cancer.
Another study has shown the obvious - taking exercise, drinking moderately, eating sufficient fruit and vegetables and not smoking can add as much as 14 years to your life, a study has found.
It doesn't require a great deal of intelligence to understand that a vegetarian diet is better for human health and the planet. However, a UK study shows that intelligent children are more likely to become vegetarians later in life.
Until a few months ago, the production of crop-based fuels in Germany was supported with generous subsidies - not any more.


I completed building prusa i3 rework. I dont have an inductive proximity sensor.
I calibrate the bed manualy.
I have calibrated four corners of the bed with paper. The middle of the bed is lower then the corners.
When i try to print something the parts close to edges are good but the center is too far to nozzle and the filamen does not stick to bed.
is there anything i can do without a proximity sensor?
When I first expedience this problem I did the best I could of setting a happy medium between the points. Using 5 Points four corners and center bed on my 220 X 270mm bed.
Which seemed to work adequately, but soon learned that the need of a capacitive / inductive proximity sensor or a BL-Touch greatly enhances the 3D Printer.
Found I could Print on Vinyl Transfer Paper Tape or Blue Painters tape and if would adhere with a greater Z-Nozzle variance.
If you have configured and flashed your own firmware most have a way of setting a manual bed leveling without a Proximity sensor in the configuration file.
What 3D Printer Controller firmware are you currently using.
The bed is 0.8mm stainless steel and looks like it is flat.
I have blue painters tape on it. I cant find why the center of the bed is lower than the edges.
I can not give you an answer as to why your 0.8mm stainless steel bed appears to be lower in the center of the bed.
I can however give you information on how to setup your Marlin to compensate for this 0.8mm stainless steel bed appearing to be lower in the center of the bed.
Read this article on Mesh Bed Leveling.
The more information you provide the easier it will become to answer correctly!
Edited 3 time(s). Last edit at 06/17/2018 09:32AM by Roberts_Clif.
Thank you. I didnt know that i can make manual mesh leveling without a proximity sensor.
I ll share the results.
Alternately,put a sheet of borosilicate glass on the bed.
I started bed leveling, ı adjusted 5x5 (25) points. I hearded the beeep from lcd. I save them to eeprom.
On menu bed leveing is "on"
I started to print bed level bech square.
Chek the bed level menu on lcd and the bed leveling is "off"
Edited 1 time(s). Last edit at 06/22/2018 05:12PM by serdar415.
Now that you got it working remember, where to come when you need information.
Come and Read all the posts here there is a lot to learn. An the more you learn the better your 3D Prints will become.
Edited 2 time(s). Last edit at 06/23/2018 08:49AM by Roberts_Clif.
I had a similar problem with my MK3 heated bed even with using 4mm glass, the glass bent with the clips.
This is good information to know.


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Our highly-experienced staff will take care of all the details. All veterans' families will be relieved of the burden of completing and filing the necessary paperwork to receive veterans' burial benefits. We will obtain the flag to drape the casket, the grave marker, and arrange military honors at burial in the cemetery of your choice-- including burial at the local national cemetery, should that be the desire of your family. We can also assist you in processing the paperwork for the military burial at sea option.
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snowy's tatting: Be still my beating heart!
My christmas present to myself this year was this pair of beautiful shuttles. They are from the shuttle shop.
My first project with them was Sadie's heart from Teri Dusenbury's site, and it has proved quite a complicated pattern, I have had to restart twice and even now there are a couple of mistakes I have ignored. Originally it was for a colleague who retires on the 31st January and who collects hearts, but I think I will have to start again. I'm not sure about my choice of thread, perhaps a solid colour would be less distracting?
Edit: I am posting the finished heart.
lovely shuttles, and from this standpoint the tatting looks great!
The shuttles are very pretty and I agree with Sherry. From here, the tatting looks great!
..."but this is not in any way to suggest that anyone has to go over and make flattering comments, it's just in case you might want to!"
The finished heart is so beautiful! I absolutely love it.
It's hard to say if a solid colour would look better of not. The shading is subtle and doesn't detract from the heart, but the only way you'll know for sure which you like best is to tat another heart in a solid colour and look at them side by side. An extra heart is never "a bad thing" because you can always find a use for it.
The finished heart looks delightful, the varigated colour suits it very well and I adore the shuttles.
Now that's interesting! (The nurse comment you left on my blog) I think there must be something in our makeup that compliments caring with creating....maybe???
I think your heart is beautiful! I love my shuttles from the Shuttle Shop! In fact I love all my hand crafted shuttles! Somehow, they make tatting more enjoyable!


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From Causes
Responsible Travel: The Bliss in Ignorance and the Pain in Information
"Is that because of us?" was Nix's question after telling her how I ended up not scratching anything off my bucket list when I visited Chiang Mai, Thailand. Nix Nicolas is a co-founder of Save Philippine Seas (SPS). "Yes," I replied with an unblinking stare. The month before, I found myself reluctant to try some…
Abandoned Dreams and New Found Being
A bittersweet smile cut across my face earlier as I browsed photos of my friends from the Foreign Service on Facebook. Four years ago, I was with them preparing for the series of the toughest exams, providing moral support to one another, sharing stories of excitement, fears, and dreams. While I am happy for them…
Skydive For Life
Skydive For Life. What is it, eh? Let's just say that my former co-worker Elvin Uy has always wanted to try skydiving but would not have enough courage to skydive just for the sake of. So let's put some cause into his dream adventure. We'll give him enough ego boost but on the way down, we'll be able to help him help a cancer patient via Cancer Warriors Foundation.
Support the Campaign for the 'Rare Diseases Act of the Philippines'
Last month, I had the pleasure and honor of being invited into the home of Philippine Society for Orphan Disorders President Cynthia Magdaraog for a very important social media project. Although I have been a social media specialist for two years already, this project has got to be the most ambitious yet the most "worth-it." The goal is to gather 500,000 signatures to rally lawmakers in passing Senate Bill 3087 or the Rare Diseases Act of the Philippines. All these signatures should be in by February 26, 2011, in time for the World Rare Diseases Day. It's a noble cause…


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Home News We're helping raise £10K for Police Officer told he can't drive again
We're helping raise £10K for Police Officer told he can't drive again
Two Cleveland Police Officers husband and Wife are appealing for help after PC Andrew Bradley has been told he can no longer drive after being confined to a wheelchair.
In February 2008 Andrew was diagnosed with Multiple Sclerosis. In September 2011 he had to inform the Road Policing Unit where he worked that he felt he could no longer carry out front line duties for the safety of himself and others. Since then, his condition has deteriorated and he is now confined to a power wheelchair 99% of the time. Luckily he still has his job, albeit at a desk in the intelligence office.
On Thursday 4th August 2016, he had a driving assessment with North East Driving Mobility to see if he could continue driving our private automatic family car. Unfortunately he was told that his current ability to drive the car was poor and was told not to drive until he had a car adapted to his needs.
This would involve a 'drive from wheelchair car' and a joystick steering system due to the tiredness he suffers in his hands and arms. The joystick steering system alone costs £40,000 so quite understandibly Motability want us to pay a certain amount towards it. We have been informed this will be a minimum of £10,000 due to having two young children and needing the space for pushchairs too.
Andrews wife Ailsa is now hoping to raise some money so her husband can continue to work telling Police Hour "We do not have this kind of money and are appealing for help in order to raise the funds for my husband to keep his independence.
"I am organising a one day 100 mile bike ride and other colleagues are trying to help me as much as they can. I would be ever so grateful if you could find it in your hearts to make a donation to my Justgiving page no matter how small it is."
Please dig deep and support the police family https://crowdfunding.justgiving.com/Andrews-car
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Posted on July 5, 2020 by Matt
'To the sounds of cricket bows'
In three days time, there will be international cricket again.
A few weeks ago, I wrote that it seemed almost a sure thing that something would cause the administrators to cancel the match, or even the series. But England is marching on, despite all the health warnings to the contrary, and unless it has been kept a deep, dark secret, no players or coaches or staff have tested positive for COVID from either side. In fact, there is little talk of the virus at all in the build up to the games. The talk on the back pages is mostly squad selection and the like. No mention of the lockdown, or the virus that has killed nearly 45,000 people in the United Kingdom.
(For comparison' sake, the Rose Bowl which will host the first Test has a capacity of 15,000. So the number deaths is equivalent to a packed Rose Bowl three times over. Chilling.)
No matter what the toll, though, the band is playing on, and it looks like we will have meaningful cricket again come Wednesday. Meaningful cricket, but cricket played under the most extraordinary circumstances. A global pandemic that has sickened 11 million and killed over 500,000. (Everyone single of those numbers represents a person with a family, please bear that mind before tweeting any "the virus is a hoax" nonsense.) And on top of the pandemic there is the worst economic catastrophe since the Great Depression. And on top of that, a worldwide call for racial justice, with protests erupting in nearly ever corner of the globe following the murder of George Floyd not 15 minutes from my house.
But. This will be the 285th Test match between England and The West Indies, dating all the way back to 1928. And so the two teams have played each other under extraordinary circumstances before. Maybe not quite as extraordinary, but it would be hubris to say that our times were the only interesting times.
They played 14 times in the 1930s, for instance. When the Great Depression was raging all over the world. Included in those 14 games was a match in Kingston in 1933, just seven months after the 1932 Bahamas hurricane, one of only a handful of category five storms to hit the region. And those 14 included a match at the Oval in August of 1939, the last England cricket match before the second World War, just a year and a month before the Blitz would begin.
And then the two teams wouldn't play each other again until January of 1948 in Bridgetown. Nearly a decade. If that is not an extraordinary circumstance, I don't know what is. The two teams meeting again on that little island after years of war and death and darkness. What does that look like? Probably about the same as it looked before the war, maybe just a little quieter, a little sadder, a little more melancholy, but also tinged with relief, a relief that the cricket is back. And then when the game started, I bet the war was all but forgotten, at least for a moment or two. Which is of course what we all hope will happen next week in Southampton.
Even after that catastrophic event in global history, the two teams met under cirucmstances far from ordinary. There was the wave of independence in the Carribean following the War, as country after country freed itself from the bonds of English imperialism. Jamaica and Trinidad & Tobago in 1962. The Bahamas in 1966. Grenada in 1974. Dominica in 1976. St. Lucia and St. Vincent in 1979. Antigua & Barbuda in 1981. St. Kitts & Nevis in 1983. The West Indies and England played 40+ Test matches over the course of those years of independence, and surely there was at least a hint of difference and change and shadow cast over the grounds as the games were played.
The two teams have been playing Test cricket against each other for nearly a century. A century that has seen monumental amounts change. The enormity of that change is impossible to quantify. To say the world was different in 1928 than it is now is one of the most profound understatements one could make. The two worlds are unrecognizable to each other. So much has happened in the last 92 years that 1928 feels like it must have happened on another planet. A World War. Independence. Revolutions. Hurricanes. Famine. Freedom. To put it in some sort of perspective, the West Indian cricketers that day in 1928 at Lord's were only 94 years removed from the end of slavery in their home nations, which is only two years longer than we in 2020 are removed from that Test match.
All of this is to say that these two teams have always, in one way or another, played under extraordinary circumstances. In 1928, West Indian cricketers had great-grandparents who were slaves. In 2020, a pandemic is burning through the world. Nothing has changed, everything has changed. But there is still cricket. And the first ball on Wednesday will be bizarre, sad and melancholy. After an over or two, though, as the game settles into itself, we will forget about how the world is on fire, and we will only know the cricket. And I think that is just fine. Cricket has proven itself over and over since 1877 that it is a survivor, that it soldiers on, that it has known extraordinary circumstances, and ordinary circumstances, and it is still here, still entertaining, still making us forget about life, if just for a while.
I am not a huge believer in the "IMPORTANCE OF SPORT" that you have probably read in articles over the last few months. That sport needs to come back to heal our nations, our societies. I think it would have been okay to wait until next year, and that would have been safer and fine. There was no reason to rush it back. We will heal with or without these little games. What sport does do, however, is show our resliliency, our ability to adapt to new conditions, and just do what we've always done. And games like cricket — with long, international histories — are better than other games at doing so. Time is vast and wide, and cricket has seen so much of it, and yet it continues, and looks more or less the same.
1928 and 2020 are worlds apart. But they both saw England play the West Indies in a few games of cricket. No amount of extraordinary shifting change can take that away from us. And it's a reminder that everything will, probably, be okay.
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The Who's Roger Daltrey Expects To Lose His Voice
John R Kennedy
Roger Daltrey, pictured in 2018. Tabatha Fireman / Getty Images
The Who's Roger Daltrey figures he'll have to stop singing around his 80th birthday.
"Obviously within the next five years I think my voice will go," the rock star told Billboard. "Age will get it in the end."
Daltrey, who is on tour this year, insisted his voice "is still there at the moment." That's good news for fans in Canada because The Who's Moving On! Tour comes to Toronto's Scotiabank Arena on Sept. 3 and Vancouver's Rogers Arena on Oct. 21.
"I mean, we're obviously coming to the twilight of our live career, and I'm glad we're getting to do something like this before it's over," Daltrey said of the tour.
In May, the singer complained about pot-smoking fans at a concert in New York City.
"I gotta tell you, all the ones smoking grass down front here, I'm totally allergic to it," Daltrey said. When the crowd laughed, he added: "I'm not kidding.
"Whoever it is down there, you f**ed my night and you made me really… I'm allergic to that s**t and my voice just goes [sound]. It sucks up. So f**k you!"
WATCH: Jennifer Lopez, Cardi B Star In 'Hustlers' Trailer
The movie opens in September.
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The singer-songwriter will play Osheaga in Montreal.
Harry Styles In Talks For 'Little Mermaid' Role: Report
The singer could be cast as Prince Eric in the remake.


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'The Amazing Spider-Man 2' Viral Marketing Teases More Villains
by Rob Frappier
– on Oct 14, 2013
Since San Diego Comic-Con this past summer, it's been pretty clear that The Amazing Spider-Man 2 is setting up the eventual appearance of the Sinister Six. In fact, the news has been all but confirmed by Paul Giamatti, who is playing the supervillain Rhino in the movie.
But if the movie's viral marketing is any indication, there may even more villains set to enter the Spider-Man movie universe, including some interesting lesser known characters.
A new article at the faux news website The Daily Bugle discusses the stock performance of Oscorp and a number of interesting developments at the company. Sharp-eyed Spidey fans will recognize several sly references to bad guys in the news.
Here's a snippet of the article:
Despite the assault on Oscorp Tower two weeks ago and the revelation that disgruntled Oscorp employee, Dr. Curt Connors, was responsible for the attack, Oscorp's stock has climbed four points.
Oscorp spokesman Douglas Menken provided some details from the meeting, including that the construction on the prototype alternative energy power plant, complete with hydroelectric tower, is on schedule for completion within the next year.
Other highlights included a preview of a flight harness for the military and significant advancements in robotics by the head of the engineering division, Spencer Smythe.
Did you catch all of the references? If not, we can help. The most recognizable reference is probably the mention of a "flight harness." I don't know about you, but those words bring to mind one guy: The Vulture. The Vulture is one of the more memorable Spider-Man villains and was even going to be played by John Malkovich in Sam Raimi's aborted Spider-Man 4. Presumably, if The Vulture ever makes it into the ASM movie universe, he will either be an employee of Oscorp or steal the technology from the company.
The "prototype alternative energy power plant, complete with hydroelectric tower" could be talking about the villain Hydro-Man. Hydro-Man gained the power to turn into and manipulate water after he was accidentally knocked from a cargo ship by Spider-Man into the ocean during the test of a, you guessed it, "powerful experimental generator."
Finally, there's Spencer Smyth, the head of Oscorp's engineering division. In the comics, Smyth is the creator of a series of robots called the "Spider-Slayers," which are designed specifically to hunt down Spider-Man.
It's unclear whether any of these characters will actually appear in The Amazing Spider-Man 2, though it isn't beyond the realm of possibility. One intriguing thought is that Office star B.J. Novak will play Smyth. After all, when Novak first joined the film, many fans speculated he'd be playing Alastair Smyth (the son of Spencer Smyth).
Colm Feore's role is still undefined, so it's possible that he could play The Vulture (as was rumored when he first joined the film). However, this conflicts somewhat with previous images that seem to suggest Feore's character will be involved with the Ravencroft Institute.
In any case, the continued references to villains both major and minor definitely gives credence to Marc Webb's comments that The Amazing Spider-Man 4 will be more than just a Spider-Man movie. At the current rate they're piling on bad guys, Spidey will have to team up with somebody to keep his head above water. Who will it be? I'll leave that for you to debate in the comments.
What do you think of these references? Will any of these characters actually end up in the movie or is this just some viral marketing fan for Spider-Man fanboys?
The Amazing Spider-Man 2 is out in theaters on May 2nd, 2014.
Source: The Daily Bugle
Tags: spider-man, the amazing spider-man, the amazing spider-man 2
Super Size Me 2 Trailer & Poster Focus On World's Most Consumed Animal


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Mindfulness Based Cognitive Therapy
MBCT
The MBCT Programme
Posted on 2 September 2007 4 April 2020 by phyllis
Segal, Teasdale and Williams collaborated in the development of MBCT. Together they have written about their research in Mindfulness-based Cognitive Therapy for Depression: A new approach to preventing relapse (Guilford, 2013), The Mindful Way Workbook (Guilford, 2014), and together with Jon Kabat Zinn, The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Guilford, 2007).
Zindel Segal
Dr. Zindel Segal is the Distinguished Professor of Psychology in Mood Disorders at the University of Toronto Scarborough and a Senior Scientist in the Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health. His research has helped to characterize psychological markers of relapse vulnerability to affective disorder. Among the books he has authored are Interpersonal Process in Cognitive Therapy,Cognitive Vulnerability to Depression, and Mindfulness-Based Cognitive Therapy for Depression: A new approach for preventing relapse. Awarded the Douglas Utting Prize for significant contributions to the understanding and treatment of depression and the Hope Award by the Mood Disorders Association of Ontario, he continues to advocate for the relevance of mindfulness-based clinical care in psychiatry and mental health.
John Teasdale
John Teasdale has worked as a research scientist, funded by the Medical Research Council, first in the Department of Psychiatry, University of Oxford, then in the Cognition and Brain Sciences Unit, Cambridge. His research has investigated basic psychological processes and the application of that understanding to the relief of emotional disorders. For many years, this research involved the exploration of cognitive approaches to understanding and treating major depression, and he was one of the pioneers of cognitive therapy research in the United Kingdom. More recently, the findings of earlier research have been applied to the development and evaluation of mindfulness-based cognitive therapy. He has received a Distinguished Scientist Award from the American Psychological Association, and has been elected Fellow of both the British Academy and the Academy of Medical Sciences. He is currently retired, pursuing personal interests in practising and teaching meditation and mindfulness training.
Mark Williams is Emeritus Professor of Clinical Psychology and Emeritus Fellow of Linacre College, University of Oxford, and was Founding Director of the Oxford Mindfulness Centre (2008-2013). The main focus of his work has been to understand how best to prevent serious clinical depression and suicide. His books include Mindfulness-based Cognitive Therapy for Depression: A new approach to preventing relapse (Guilford, 2013) with Z. Segal and J.D. Teasdale; The Mindful Way Workbook (Guilford, 2013); Mindfulness: A Practical Guide to Finding Peace in a Frantic World (London, Piatkus, 2011), with Danny Penman, Cry of Pain: understanding suicide and self harm (Piatkus, 2014), and Mindfulness and the Transformation of Despair: working with people at risk of suicide (New York, Guilford, 2015), with M. Fennell, T. Barnhofer, R.Crane, and S. Silverton. Now retired, he continues his research (focussing currently on mindfulness training in young people), to teach mindfulness to teachers-in-training across the world, and to explore, with colleagues, how mindfulness and compassion might most authentically be cultivated in evidence-based public policy. He is a Fellow of the British Academy and of Academy of Medical Sciences, and an honorary Canon of Christchurch Cathedral, Oxford.
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Anterior Approach to Hip Replacement, Orthopedic Knee Surgery medical centers in Vienna, Austria
Anterior Approach to Hip Replacement, Orthopedic Knee Surgery, Vienna, Austria
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DNA blood test spots cancers in seemingly cancer-free women, but also produces false alarms
Blood containing DNA shed by cancer cells may reveal hidden tumors.
TEK IMAGE/Science Source
By Jocelyn Kaiser Apr. 28, 2020 , 1:40 PM
Detecting many kinds of cancers early, with a simple blood test for DNA shed by tumor cells, is a seductive prospect. Such tests, often called liquid biopsies, are now stepping out of the lab. This week a pioneering real-world study confirms some of their promise—and highlights a potential drawback that may soon confront physicians, regulators, and the public: a small but not insignificant number of alarming but false detections.
In the first trial of such a test in a large, general population, instead of in groups with known tumors or at high risk of cancer, researchers screened nearly 10,000 women with CancerSEEK, an assay for circulating tumor DNA developed at Johns Hopkins University. It detected 26 previously unknown tumors, they report online in Science and at a virtual session of an American Association for Cancer Research meeting today.
Observers say the results are promising, but leave key questions unanswered. "I'm very impressed with this paper. They did all the right things. But it does not mean the assay should be put on the market and sold," says breast cancer researcher Daniel Hayes of the University of Michigan, Ann Arbor. It's not yet clear that the early warnings saved the women's lives. And 101 of the women who had a positive test and received followup imaging turned out not to have cancer; 22 of them underwent fruitless invasive tests such as an endoscopy.
The earlier cancer is detected, the better—but not always, as some tumors may never grow enough to need any treatment. And false alarms can lead to needless anxiety and unnecessary procedures. Such concerns fuel debates over the frequency and worth of existing screening methods such as mammograms and colonoscopies, and the concerns are amplified for cancer blood tests because they promise to make it easy to screen millions of healthy people.
To explore those issues with an early version of CancerSEEK, the Geisinger Health System in Pennsylvania recruited women between the ages of 65 and 75 who had no known cancer history. CancerSEEK pulls circulating DNA from a blood sample and looks for mutations in 16 genes known to drive the growth of various cancers. It combines this information with established protein biomarkers for some cancers. If a woman's test was positive, an expert panel decided whether she should get a second blood test to confirm the initial finding and rule out molecular changes in her blood that might have fooled the first test. If the positive test appeared real, the woman was invited to undergo full-body imaging.
Mixed signals
One-year follow-up results of the DETECT-A study of nearly 10,000 women, ages 65 to 75.
Initial blood test 9911
Cancers detected with blood test 26
Cancers detected with standard screening 24
Cancers detected with neither approach 46
Total cancers detected 96
Imaging based on false blood test 101
Invasive diagnostics after false blood test 22
Lennon et al.
During participants' first year in the study, dubbed DETECT-A, the Hopkins test picked up 10 types of cancer in 26 women, roughly double the number found with conventional screening. Seven of the cancers, such as ovarian, have no approved screening test and are often deadly because they are rarely found early. Seventeen of the 26 women had early-stage cancers that had not spread far, beyond nearby muscle and lymph nodes. Most of the 26 had surgery or are undergoing treatment and 12 are in remission, suggesting they did benefit from the test.
The DETECT-A study "makes great strides in its approach," says ovarian cancer researcher David Huntsman of the University of British Columbia, Vancouver. But more data attesting to an overall survival benefit from testing are needed, he and others stress, before the blood test should be approved for widespread use.
The 101 false positives is a modest number given the scale of the study, Huntsman and Hayes say. But the test also had false negatives. Conventional screening over the DETECT-A study's first year of follow-up found breast, lung, and colon cancers in 24 women whose CancerSEEK test was negative. Tumors in 46 more women became apparent through symptoms or other reasons. The Hopkins team views its test, which it has continued to improve, as "additive and complementary" to standard screening, says Nickolas Papadopoulos, who led the study with Kenneth Kinzler and Bert Vogelstein.
Some public health experts have worried that if a blood test were available, people might shun these other, proven screens. But participating in the study didn't deter the women from continuing mammograms. And in a follow-up survey completed by nearly 6900 women, only 0.3% said they regretted participating in the study, including only one of 120 with a false positive or negative result. The DETECT-A study "suggests that multicancer blood-based screening is safe and feasible," says oncologist Minetta Liu of the Mayo Clinic.
Liu is part of an academic group running studies of another blood test, developed by the biotech Grail, which looks at patterns of methyl groups on cell-free DNA to detect cancers. In a March paper in the Annals of Oncology and at the virtual cancer meeting, Grail shared the latest results from a study that enrolled 15,000 people, some with newly diagnosed cancer and others with no evidence of the disease. Its test for 50 cancers had a detection rate of 44% for early- to midstage cancer and also determined the site of the known cancer in 93% of cases, which could reduce the need for full-body imaging. In December 2019, the company launched PATHFINDER, a prospective study of 6200 people—all older than 50 and 70% at elevated risk for cancer. "This is an important next step toward the commercialization of our test," says Grail spokesperson Kelsey Grossman.
As for when CancerSEEK might reach the clinic, a startup company called Thrive owns the rights to further develop the test. It raised $110 million last year and is planning a large followup trial designed to earn regulatory approval. Questions persist about how officials and expert groups that set screening guidelines, such as the U.S. Preventive Services Taskforce, will weigh early cancer detection tests. Will decade-plus studies that show survival benefits be required, for example, as they were for other screening methods such as mammograms and lung scans for smokers? Or can proxies, such as data showing the tests find more early cancers than existing screening methods, satisfy the various groups? "That is what everybody in the field is grappling with now," Papadopoulos says.
source: sciencemag.org
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New China H7N9 bird flu cases 'signal potential winter epidemic'
A breeder covers his face as he sits behind his chickens, which according to the breeder are not infected with the H7N9 virus, in Yuxin township, Zhejiang province, in this April 11, 2013 file photo. Fresh human cases in eastern China of a deadly new strain of bird flu signal the potential for "a new epidemic wave" of the disease in coming winter months, scientists said on Thursday. -- FILE PHOTO : REUTERS
Oct 25, 2013, 6:18 am SGT
http://str.sg/Zmum
LONDON (REUTERS) - Fresh human cases in eastern China of a deadly new strain of bird flu signal the potential for "a new epidemic wave" of the disease in coming winter months, scientists said on Thursday.
The strain, known as H7N9, emerged for the first time in humans earlier this year and killed around 45 of the some 135 people it infected before appearing to peter out in China During the summer.
But a new case in October in a 35-year-old man from China's eastern Zhejiang province shows that the virus "has re-emerged in winter 2013" and "indicates a possible risk of a larger outbreak of H7N9 this winter," according to Chinese researchers writing in the online journal Euro surveillance.
Flu experts around the world have been warning that despite the marked drop off in cases during the summer months, the threat posed by H7N9 bird flu has not passed.
Mr Ab Osterhaus, a leading virologist based at the Erasmus Medical Centre in the Netherlands who has been tracking the virus, told Reuters earlier this month: "We're bracing for what's going to happen next."
The first scientific analysis of probable transmission of the new flu from person to person, published in the British Medical Journal in August, gave the strongest proof yet that it can jump between people and so could potentially cause a human pandemic.
And another study published in August identified several other H7 flu viruses circulating in birds that "may pose threats beyond the current outbreak".
In a detailed analysis of the 35-year-old man's case, scientists from the Zhejiang Provincial Centre for Disease Control and Prevention said it differed from previous ones in that it was a severe case in a younger patient "with no obvious underlying diseases and no obvious recent direct contact with live poultry".
Most laboratory-confirmed cases in the past had been people over the age of 60, many of whom said they'd had recent exposure to poultry, generally at live bird markets.
The case of the 35-year-old man, plus another H7N9 infection confirmed just a day ago, suggest the virus "has apparently continued to circulate in an animal reservoir during the summer", the researchers said.
The second October case is a 67-year-old man with no underlying disease whose work included transporting and selling poultry.
The researchers said that based on China's experience in the spring, when there were 30 cases in March and 88 in April, the best approach now would be to maintain enhanced and expanded surveillance in human and animal populations to make sure any new cases of H7N9 are picked up and diagnosed swiftly.
"In particular, enhanced surveillance in poultry would be helpful if it can identify the H7N9 virus and inform early control measures before human infections occur," the Chinese scientists said.
"Hygiene campaigns and closure of live poultry markets can reduce the risk of severe cases and deaths."


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Factor Analysis in Marketing Research
Home > What We Do > Research Methods > Statistical Techniques > Factor Analysis in Marketing Research
Factor analysis in marketing research aims to describe a large number of variables or questions by using a reduced set of underlying variables, called factors.
To find out more about factor analysis and how it can help your business
What is factor analysis in marketing research?
Factor analysis explains a pattern of similarity between observed variables. Questions which belong to one factor are highly correlated with each other; unlike cluster analysis, which classifies respondents, factor analysis groups variables.
There are two types of factor analysis in marketing research: exploratory and confirmatory. Exploratory factor analysis is driven by the data, i.e. the data determines the factors. Confirmatory factor analysis, used in structural equation modelling, tests and confirms hypotheses.
Factor analysis in market research is often used in customer satisfaction studies to identify underlying service dimensions, and in profiling studies to determine core attitudes. For example, as part of a national survey on political opinions, respondents may answer three separate questions regarding environmental policy, reflecting issues at the local, regional and national level. Factor analysis can be used to establish whether the three measures do, in fact, measure the same thing.
It can also prove to be useful when a lengthy questionnaire needs to be shortened, but still retain key questions. Factor analysis indicates which questions can be omitted without losing too much information.
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The research was thoroughly conducted and all the project objectives were exceedingly met.


text:
Phlebotomist 2 - VUMC Diagnostic TVC Phlebotomy Laboratories
Health Analytics & Data Manager
Rosslyn, Virginia
Laboratory Research Assistant
Indiana University Purdue University Indianpolis - IUPUI
Indianapolis, Indiana,
Administrative Laboratory Assistant, Molecular & Cell Biology (4723C) - 29701
Phlebotomist 2 , MCE - VUMC $2,000.00 Signing Bonus & Employee Referral Program
Senior Data Manager (Data Engineer)
Oncologist / Hematologist
PostDoctoral Associate in Biophysics and Structural Biology
Laboratory Assistant 1, Molecular & Cell Biology (9605C) - 29693
Genetic Counselor - OB/GYN - Mineola and Hempstead
Mineola/NY/USA
HD Payroll/Personnel Tech
Quality Assurance Lead Technician (Research Compliance Assistant)
Research Technician I/II - Kiem Lab
To apply, follow the employer's instructions.
To apply, follow the
employer instructions.
Location: Nationwide
Internal Number: 2781688
School of Medicine, Stanford, California, United States
Job Code: 4732
Employee Status: Regular
Grade: H
The Byers Eye Institute at Stanford University School of Medicine is searching for a bioinformatician with expertise in the analysis of genome-wide datasets related to gene expression. While reporting directly to the Chairman Dr. Jeffrey L. Goldberg, the applicant will collaborate with faculty in the Department who are performing projects in the field of Vision Research requiring bioinformatics expertise. The Research Engineer will contribute to project design, acquisition of data, interpretation, and publication of
About Stanford University
Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 12000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu. Stanford is an equal empl...oyment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford also welcomes applications from others who would bring additional dimensions to the University's research, teaching and clinical missions.
Connections working at Stanford University
https://careers.ashg.org/jobs/16121334/research-engineer


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Theater, Architecture, Livability : Toronto, City That Works, Basks in Its 'Golden Age'
By KENNETH FREED
TORONTO —
A television crew shooting a series supposedly set in a typical American city found that the streets here were too clean, so they spread around some synthetic garbage to lend authenticity to the scene. But then the crew members took a break and returned to find that Toronto's ever-present street cleaners had swept in and cleaned it all up.
The story reflects one of the most attractive aspects of this city of 3 million people. It is clean--so clean that litterers are often advised by people who catch them that "we don't do that here."
Toronto is also very safe. Thirty-seven homicides were committed here last year, in contrast with 887 in Los Angeles--and all but four of them were solved. The general crime rate is among the lowest in the world's major cities.
Economic Disparities, Too
Toronto is also rich, so rich as to cause concern that the gap between rich and poor is getting out of hand.
And Toronto is diverse, cosmopolitan, growing, dynamic and, if not beautiful in the sense that Paris is beautiful, nonetheless pleasing to the eye. People live in the city center, and it is as lively at night as at noon. Even the weather is far from fearsome: Omaha is colder in January than Toronto.
All this and more leads Jane Jacobs, a prominent urban expert, to call Toronto "the city that works," and Mayor Art Eggleton to proclaim the lakeside metropolis "North America's supercity enjoying its golden age."
By virtually all accounts, these labels are accurate--for the moment and on the surface. But judging from the clogged traffic, the lack of rental property and the extraordinary cost of housing, Toronto may be in danger of choking on its own success. In the mayor's assessment, it comes too close to wallowing in smugness and complacency and becoming "a rich man's town."
'Toronto the Good'
To understand this, one has to look back. Until the early 1970s, Toronto was considered by many to be dull and conservative, a stultifying backwater. It was known as "Hogtown" because of its stockyards, and "Toronto the good" because of laws so restrictive that cocktail lounges were prohibited and public transportation was shut down on Sundays.
Montreal was Canada's social, fashion and entertainment center, and it far surpassed Toronto as a financial and business hub. Vancouver was livelier and, with its nearby mountains and stunning beaches, was deemed more beautiful.
Then, in the early 1970s, a number of events combined with new political leadership to create a new Toronto--a city far different from what it had been before.
Montreal, divided by controversy over the effort to create a new, French-speaking country out of Quebec, lost many important businesses and financial institutions and a large part of its English-speaking population. The beneficiary was Toronto.
New Breed of Politician
At the same time, government policy at the federal level and here in the province of Ontario led to the creation of new industries--triggering growth in employment, population, investment and wealth and the emergence of Toronto as the cultural and entertainment center of Canada.
After decades of conservative, even reactionary, local government, a new breed of politician took over, led by then-Mayor David Crombie. The policy was to develop the city center, to create an extensive public transportation system and to encourage diverse and affordable residential neighborhoods.
The results have been dramatic.
Within walking distance of Bay and King streets, the hub of what might be compared to Los Angeles' financial district, thousands of people at every economic level live in attractive housing.
Entertainment-Oriented City
The downtown area is also the site of many new and well-designed office towers, including a complex designed by the renowned architect Ludwig Mies van der Rohe, new and refurbished concert halls, theaters and restaurants. Nearby, construction is under way on a domed stadium for the Toronto Blue Jays, one of the most successful major-league baseball franchises.
There are enough theaters so that a new play can be seen almost every week of the year. The local version of "Cats" was considered equal to the Los Angeles, New York and London productions. The city boasts a symphony orchestra, a permanent opera troupe and the National Ballet Company.
Torontonians attend more movies, on a per-capita basis, than the people of New York or Los Angeles. Moreover, Toronto is now the world's No. 3 film and television production center.
There are an estimated 40 distinct ethnic groups among the population of 3 million, providing five separate Chinatowns and large Italian, Portuguese and Greek neighborhoods. And there is little of the racism and violence found in many U.S. cities.
Respect for Authority
The subways, streetcars and buses run on time, and they are clean, quiet, comfortable and safe. The entire metropolitan area is safe. A woman can walk just about anywhere at night without fear. What little organized crime there is consists, for the most part, of gambling.
Much of the credit for all this can be given to a large (7,000 members) and efficient police force, a tradition of respect for authority, and a national social welfare policy that mitigates poverty and class resentment.
"I attribute this divergence from the American experience to the ghettoization of Harlem in New York in 1904," said James Lemon, a historian and urban geographer at the University of Toronto. "We in Toronto have never had that type of segregation and racial problem, at least not to the same extent."
Beyond the relatively low level of crime, mob and otherwise, Toronto has never been burdened by official corruption or even the drawbacks of political patronage.
Well-Designed City
Instead, according to historian and city archivist Victor L. Russell, "we've always had a democratically run city with professional civil servants providing good municipal services."
Lemon attributes these qualities to tradition built on the attitudes of the somber and sober English and Scottish settlers and on a "sense of restraint that came about, in part, from viewing what was going on" in the United States.
Mayor Crombie and his successors worked to prevent the city center from being abandoned, but they also used the public transportation system to promote downtown-like areas of office buildings, department stores and smaller retail shops throughout the city. The result is a balance that puts most residents within walking distance of nearly everything they want or need, often including their places of work.
These outlying areas, like nearly all parts of Toronto, are clean. The government spends almost $8.5 million a year on sanitation, more than double the outlay for that purpose in Detroit, the nearest American metropolis.
Crowded but Clean
In addition, tens of millions of dollars are spent on street maintenance. Traffic problems are commonplace in the summer months, but the streets are smooth and clean.
All this is paid for by the people, who according to a recent public opinion poll are overwhelmingly willing to give up even more in taxes to continue and expand those services.
"There is little doubt," archivist Russell said, "that our civic government has been spectacular and has always done things for the public. In fact, it has threatened the private sector by taking away business when it didn't or wouldn't serve the public interest."
But now Toronto faces the possibility that its very success is leading to a lessening--if not the destruction--of what makes it what it is.
"We are increasingly being segregated into rich and poor," City Councilman Jack Layton said. "It is a golden age--if the measure is gold."
Problem of Homeless
Last year, he said, "there was a record in the value of building permits, but at the same time more food banks were opened and more people were living in the streets than any time since the Depression (of the 1930s)."
Layton and other city officials estimate that there are 10,000 homeless people in the city, spending their nights on the streets or in shelters for transients.
"Over the last 10 years, we have lost 10,000 housing units," Layton said, "while at the same time we have vacant office space equal to 10,000 apartments. Of 10,000 housing units authorized for new harbor-front development, only 400 apartments are reserved for lower-income families. Something has gone wrong. . . . The single greatest problem we face is the division of wealth."
Underlying his point is that in a city where only 40% of the householders own their homes, less than 1% of rental units are available at any given time. This has meant high prices for all types of housing. The few rental units that go on the market are expensive; a one-bedroom apartment commonly rents for $1,000 a month.
Exorbitant House Prices
Houses are more expensive. The price of the average three-bedroom house is over $200,000, and slightly larger houses often bring well over $500,000.
The situation got so serious last spring that real estate dealers put up houses for auction, fixing the asking price as the minimum bid.
"The real Achilles' heel for Toronto," historian Lemon said, "is the cost of real estate. We've got to get more housing at a reasonable price, or we are in danger of losing the social mix that has made Toronto a livable city."
Another threat to the general atmosphere of prosperity and livability, according to Mayor Eggleton, "is smugness and complacency."
Both are much in evidence. To read the Toronto newspapers and listen to many influential residents, Toronto has surpassed New York, Los Angeles and London as a cultural center.
Still Lacks Excitement
Although live theater is everywhere, most plays close after short runs and they seldom go elsewhere. The most successful Canadian playwrights work in the United States.
The symphony performs in an inadequate hall and is, according to critics, far from first-rate; they say it is surpassed by the renowned Montreal Symphony. The opera is considered conservative and old-fashioned.
And if many movies are made on location here, nearly all are made by Americans. American film makers find Toronto attractive because its lack of identifiable character enables them to adapt it to American scripts.
With its insular self-consciousness, Toronto still lacks the excitement and European style of Montreal, and the warmth, beauty and easy informality of Vancouver.
Barry Callagahan, a leading Canadian writer and critic, says that "Toronto is to world-class cities what one critic said about Somerset Maugham--it's right down in the first row of the second rank."


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John Calvin puts forward a very simple reason why love is the greatest gift: "Because faith and hope are our own: love is diffused among others." In other words, faith and hope benefit the possessor, but love always benefits another. In John 13:34–35 Jesus says, "A new command I give you: Love one another. As I have loved you, so you must love one another. By this everyone will know that you are my disciples, if you love one another." Love always requires an "other" as an object; love cannot remain within itself, and that is part of what makes love the greatest gift.
Americans Have Become Dramatically More Concerned About Immigration
By Support, January 4 in Political Conservative News
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Den: Christian
By Jason Hopkins -
A significantly higher percentage of Americans have listed immigration as an issue that they hope the federal government will work to address in 2019.
Forty-nine percent of Americans have chosen immigration as a top priority. The numbers are a far climb from the same poll last year where only 27 percent of respondents singled out immigration as a top concern. Such an increase indicates President Donald Trump's rhetoric on illegal immigration, and the current battle in Congress, is grabbing the nation's attention.
The recently-released survey — conducted by the Associated Press-NORC Center for Public Affairs Research — asked respondents to choose which issues they hoped the government would solve this year, allowing them to pick up to five different categories. The "economy/economic issues" grabbed a commanding lead, with 62 percent of respondents listing it as a problem. "Immigration" tied with "health care" for second place.
Unsurprisingly, the priority Americans take on immigration varies among partisan affiliation.
Sixty-Five percent of Republican respondents chose immigration as one of their top five concerns, whereas only 37 percent of Democrats did the same thing. However, both parties saw marked increases over the past year. With 42 percent of Republicans and 20 percent of Democrats listing immigration as a top issue when the survey was conducted in December 2017.
"We waste too many resources with illegal aliens," David Hoyt, a registered Republican living in Iowa and a retired school superintendent, told the Associated Press. "If people want to come here, let's have them do it legally. I don't understand why people don't understand the word 'illegal.'"
Since entering the Oval Office, Trump has remained vocal about addressing illegal immigration on the country's southern border. The federal government is currently under a "shutdown" as congressional Democrats and the White House continue to spar over proposed funding for a wall on U.S.-Mexico border. Trump has indicated that he is willing to let the government shutdown remain in place for months — even years — until Democrats relent on spending for a border wall.
"Without borders, I've said it many times, we don't have a country. I hope it doesn't go on even beyond a few more days. It really could open very quickly," the president told reporters on Friday.
Actions taken by the American public also indicate a surge in concern over illegal immigration. A GoFundMe page asking for donations to pay for Trump's border wall has so far accumulated over $18 million from more than 300,000 donors — numerous donors have given $10,000 or more.
The AP-NORC survey reached 1,067 adults and was conducted between Dec. 13 and 16. The poll has a margin-of-error of 4.1 percentage points.
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