I've found that if we care for our people, they'll care for our clients. This belief is what powers Grant Thornton's culture.
A caring culture is woven through our firm. We began our culture journey 10 years ago, and we'll never stop. Everyone knows the conduct expected of him or her and how to live our values at all levels. We're very collegial, with leaders truly caring for our employees and leveraging culture concepts in everything we do.
Our culture makes it easier for younger professionals to approach our leaders for mentoring advice. I've enjoyed being a mentor to a number of employees seeking to adjust to life events or advance in their career. I believe strongly in this responsibility. It's also a way for me to give back to my early mentors who invested in me. My mentors were primarily a host of male leaders; I leveraged aspects of their style that resonated and blended them together to make me the leader I am today.
At the time I joined Grant Thornton, it was fairly rare to be a partner and a mom. I had to learn to be effective in both worlds. It was challenging and gratifying at the same time, and it couldn't have been done without the firm's supportive culture. I was empowered to build a rewarding career while being an engaged wife and mother.
The experience proved to me the value of being purposeful about inclusion. When I joined Grant Thornton in 2002, only 8% of partners were women. I became a member of a small team of female leaders who created the Women at Grant Thornton business resource group (BRG). Over the years, we've formulated programs that focus on recruiting, retaining and advancing women within the firm — making sure benefits are appropriate and include flexibility in work arrangements. We've made a lot of progress; now 20% of our partnership is female, which is consistent with our larger competitors.
With momentum gained in gender, I expanded our diversity efforts to include many forms of diversity. In addition, as part of the People and Culture leadership team, we led an exploration into our employees' experiences and perceptions where many employees named being part of a community as one of the reasons for their loyalty to the firm. I understand; it's essential to give employees opportunities to get involved and connect as they build a career. Women at Grant Thornton continues to be a vital connector, and our other BRGs have piqued employee interest and are gaining similar momentum.
Creating an intentional culture is a focus in organizational strategy, the practice I lead as a Grant Thornton partner. As I assist organization leaders in making change to achieve goals, I advise paying great attention to their people experience through the whole process and allowing plenty of time to socialize organizational change. Conducting a thoughtful change process is an important component of culture that I learned more about as a founding member of our firm's culture leadership team. If people's jobs will be impacted by a structural or policy change, we need to help them navigate the change, by being transparent and supporting them through the uncertainty.
Because of my experiences leading our culture journey and developing communities, I know that a healthy, high-performing culture and an inclusive environment drive strategic results. I assure clients that by investing in culture, as our firm has done, and appreciating diverse points of view, they'll realize their strategic priorities such as attracting and retaining valued employees. This is the mutually beneficial outcome we enjoy at Grant Thornton. It's why I encourage my clients, mentees and others to believe in the power of an intentionally shaped culture.


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Blog Access Bank Acquires Diamond Bank - What it Means
Access Bank Acquires Diamond Bank – What it Means
In Industry News, Music Business by Africa Music Law™ December 18, 2018 Leave a Comment
Nigeria's Access Bank has announced the merger and acquisition of its competitor Diamond Bank. From the outside looking in, it appeared the latter was healthy, but it was not and there were many telltale signs including a decision to abandon its international operating license, a Central Bank of Nigeria Fine of 250 Million Naira, non-performing loans and plunging share prices, chairman and non-executive director resignations, and the S & P downgrading the bank's ratings, all within this year.
So, in simple English, what does the new deal mean?
In the statement from Diamond Bank republished below, it means that the board of directors for Access and Diamond have approved the merger of the two banks. What is left is to get the approval of their respective shareholders. Once they obtain the approval, Diamond Bank will no longer exist and as it becomes part of Access Bank.
As a reminder for those needing the primer, a corporation is an independent entity that lasts in perpetuity. Its shareholders are those who contribute capital to the corporation. Its directors and officers help manage it. The board of directors specifically wield significant power and manage and supervise the business of the corporation. When a mergers and acquisitions transaction occurs like the one here, there are many ways to negotiate the deal, in this case, the transaction type is a merger.
Read the press statement from Diamond Bank below:
The Board of Diamond Bank Plc ("Diamond Bank") today announces that following a strategic review leading to a competitive process, the Board has selected Access Bank Plc ("Access Bank") as the preferred bidder with respect to a potential merger of the two banks ("the merger") that will create Nigeria and Africa's largest retail bank by customers.
The Board of Diamond Bank believes that the merger is in the best interest of all stakeholders including, employees, customers, depositors and shareholders and has agreed to recommend the offer to Diamond Bank's shareholders. Completion of the merger is subject to certain shareholder and regulatory approvals.
The proposed merger would involve Access Bank acquiring the entire issued share capital of Diamond Bank in exchange for a combination of cash and shares in Access Bank via a Scheme of Merger. Based on the agreement reached by the Boards of the two financial institutions, Diamond Bank shareholders will receive a consideration of N3.13 per share, comprising of N1.00 per share in cash and the allotment of 2 New Access Bank ordinary shares for every 7 Diamond Bank ordinary shares held as at the Implementation Date. The offer represents a premium of 260% to the closing market price of N0.87 per share of Diamond Bank on the Nigerian Stock Exchange ("NSE") as of December 13, 2018, the date of the final binding offer.
Immediately following completion of the merger, Diamond Bank would be absorbed into Access Bank and it will cease to exist under Nigerian law. The current listing of Diamond Bank's shares on the NSE and the listing of Diamond Bank's global depositary receipts on the London Stock Exchange will be canceled, upon the merger becoming effective.
Diamond Bank expects the transaction to complete in the first half of 2019.
Uzoma Dozie, the Chief Executive Officer of Diamond Bank, said: "The proposed combination with Access Bank will create one of Africa's leading financial institutions. There is a clear strategic rationale for the proposed merger and strong complementarities between the two institutions. While Diamond Bank has pioneered Nigeria's largest technology-led retail banking platform, Access Bank is one of Nigeria's leading full-service commercial banks. Consolidation in the Nigerian banking industry is an inevitable, natural progression in a sector where the gap between Tier 1 and Tier 2 banks has been widening and scale has become critical; where technology will disrupt the traditional business model while enabling broader financial inclusion.
The board of Diamond Bank believes that the proposed combination of the two operations provides an exciting prospect for all stakeholders in both businesses and will create a financial institution with the scale, strength, and expertise to capitalise on the significant opportunities in Nigeria and sub-Saharan Africa more broadly."
Herbert Wigwe, CEO of Access Bank, said: "Access Bank has a strong track record of acquisition and integration and has a clear growth strategy. Access Bank and Diamond Bank have complementary operations and similar values, and a merger with Diamond Bank, with its leadership in digital and mobile-led retail banking, could accelerate our strategy as a significant corporate and retail bank in Nigeria and a Pan-African financial services champion. Access Bank has a strong financial profile with attractive returns and a robust capital position with 20.1% CAR as at 30 September 2018. We believe that this platform, together with the two banks' shared focus on innovation, financial inclusion, and sustainability, can bring benefits to Access Bank and Diamond Bank customers, staff and shareholders."
Exotix Capital acted as international financial advisor to Diamond Bank, and Templars acted as Nigerian legal counsel.
This announcement contains inside information for the purposes of Article 7 of the Market Abuse Regulation (EU 596/2014) ("MAR") and is disclosed in accordance with Diamond Bank's obligations under Article 17 of MAR.

redpajama_set_name: RedPajamaCommonCrawl


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The 2018 Formula One is more than just a race. It's an experience.
By	orbitworldtravel
The FIA Formula One World Championships are about so more than just car racing. This epic extravaganza weaves its way through 21 countries over more than nine months, and features stunning panoramas, a super-charged atmosphere and, of course, the best-of-the-best in terms of racing royalty. Here you can rub shoulders with the glamorous and the wealthy, experience the cultures and cuisines of some of the world's most beautiful cities, and soak up the fume-fuelled frenzy that sums up this premier street circuit event.
Formula One racing has its roots in the European Grand Prix championships of the 1920's and 30's and is currently the highest class of single-seat auto racing sanctioned by the FIA. The FIA Formula One World Championships have been the premier form of racing since the inaugural season in 1950, and the season consists of a series of races known as Grand Prix held worldwide on purpose-built F1 circuits.
With seven world titles, Michael Schumacher has statistically been the greatest Grand Prix driver of all time, however, more recently, Michael Schumacher, Ayrton Senna and even our own Sir Jack Brabham have all graced the heralded walls of the event's unofficial Hall of Fame. With many of next year's drivers still to be contracted, die-hard fans will be thrilled to know that Australian Daniel Ricciardo is a certainty to gear-up for a stint with the Red Bull Racing team.
Formula One cars are the fastest road course racing cars in the world, can reach up to 375 kilometres an hour at top speed and are capable of a lateral acceleration of over five G's around corners (that's G-Force for the novices and that's super-fast!)
And while Europe is its traditional base, the sport's scope has expanded significantly and an increasing number of Grands Prix are held at a variety of other must-see destinations across the globe. International cuisine, diverse cultural experiences and the turbo-fuelled excitement of one of the world's most famous sporting events … what more could you want from a holiday?
2018 marks the 72nd season of Formula One motor racing and the 69th Formula One World Championship. The season kicks off with the Australian Grand Prix in downtown Melbourne on the 25th March, and concludes with the Abu Dhabi Grand Prix on the 25th November at the Yas Marina Circuit.
Along the way, the event traverses 21 countries including Spain, Monaco, France, Britain, Germany, Russia, Singapore, Japan, the US and Brazil, and features world-renowned teams including Scuderia Ferrai, Mercedes AMG Petronas Motorsport and the McLaren Honda Formula 1 team.
Given the majority of F1 circuits these days are located in or close to major cities, having a range of flight options is a given and also limits the chances of you having to pay an 'F1 surcharge'.
Your Orbit World Travel agent can also book an organised tour for you, where you'll have access to the best Grand Prix viewing tickets, circuit transfers, experienced tour guides and accommodation close to all of the F1 racing action. For car-mad enthusiasts, fantastic sightseeing packages are also on offer, which include captivating guided tours to some of the world's best car museums and motor manufacturing plants.
We can also organise access to comprehensive tour guides that cover all the Grand Prix events, and give you detailed information on circuit maps, event schedules and the best grandstands to view all of the action. Tour packages are the ideal way to ramp up your whirlwind F1 experience – your most difficult decision will really be which country (or countries) you choose to enjoy it in!
Combine your love of travel with your 'need for speed' with Orbit World Travel. We can help fine-tune your F1 experience by accessing the most cost-effective flights, offering a range of accommodation options and advising you on some of the best tour packages that will guarantee you make the most out of your fun-fuelled adventure.
Register now and one of our expert consultants will be in touch with you shortly to discuss all of your travel needs.
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After much attention swarmed over the court troubles of TaxMasters last week, many consumers are left questioning the legitimacy of tax debt relief services. Although TaxMasters is in trouble for mismanaging funds and allegedly scamming customers, there are plenty of reputable tax debt relief services available. The trick is knowing what to look for and how to go about resolving your tax debts.
TaxMasters was a key player for many years, providing one of the largest scaled tax debt relief operations in their area. Even though they advertised heavily on radio and television, consumers should not be automatically turned off by a company that has similar means of communicating with potential customers. The trouble most people encounter when attempting to resolve their debts is a lack of knowledge about their options.
Consumers should know that back taxes can be resolved directly with the IRS. There may not be a need to use the services of a third party company, but if additional help is desired consumers should consult with a tax attorney before deciding on how to proceed. Further, the programs offered by the IRS may also be claimed by certain third party companies. An Offer In Compromise or an installment plan is only legitimate if it is approved by the IRS. Anyone looking into one of these programs should ensure they always obtain written approval directly from the IRS and never assume a deal is negotiated on their behalf. Lastly, consumers should get to know the IRS better. Their website is full of helpful information that can better educate consumers about general tax information, laws and even ways to lower their tax liability.
Not all tax debts are the same, which means that different types of tax debt are resolved differently. While most people look for ways to resolve their debts directly with the tax assessor, there are certain programs available to help those who cannot afford to repay their debts in one lump sum.
Income tax debts are the most common type among taxpayers. They arise from large tax liability burdens and foreseen circumstances. While most people assume tax debts are not eligible for bankruptcy protection, some income tax debts may actually qualify.
In general, tax debts must meet the following conditions in order to be eligible for a debt discharge: (a) older than three years, (b) have a corresponding tax return filed with the IRS and (c) not be associated with fraud. The IRS also offers for taxpayers to resolve their debts through an installment plan or Offer in Compromise. These programs are used to help taxpayers that cannot afford to repay their debts quickly or in one payment.
Business tax debts, such as past due payroll taxes, are different than income taxes. Because these debts are important for maintaining business operations, owing the IRS business taxes can put the future of the company at risk. Tax liens, wage garnishments and seizure of operations are all steep consequences associated with business tax debts. However, the IRS does offer ways for businesses to get caught up on their tax debts and remain without consequences. Business owners may be able to negotiate a payment arrangement directly with the IRS.
Property taxes are also a cause for concern among taxpayers. Unlike personal taxes, back due property taxes can lead to liens against the property and, in some cases, foreclosure. Homeowners who are significantly delinquent on their property taxes may find that their homes are at risk of seizure. However, most property tax assessors also offer tax repayment programs that help the homeowner get caught up over a series of smaller payments.


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Firefighters Asking For Help Keeping Hydrants Clear of Snow
(ABC 6 News) -- With thousands of hydrants across the city, Rochester firefighters are asking people to help.
Fire trucks carry between 650 and 800 gallons of water, meaning crews need to find the water source within about three minutes. If hydrants are buried under the snow, their approximate location can be seen on a GPS tracker.
"If you have a 5 to 6 foot snow drift, we have pipe holes to try and narrow it donw, but it's a needle in a haystack, basically," said Capt. Ben Davis of the Rochester Fire Department.
Even once a hydrant is found, digging it out takes time, when every second counts.
According to the Minnesota State Fire Marshal, a fire doubles in size every minutes. The division sent out a few firefighters, set a timer, and showed just how long it can take to get to a buried hydrant.
By the end of the demonstration, more than three minutes had been spent shoveling before water could flow.
After last weekend's storm, Kasson firefighters say they spent hours freeing more than 100 hydrants, but with more than 700 hydrants in Kasson, crews there are calling on property owners to do their part.
And to help crews even more, you can get a hydrant marker installed.
"Especially maybe if we have a late night snow or something like that, people haven't had a chance to clear their hydrant, at least there is a flag sticking out of the snowbank, we know it's there; we're not just guessing," Davis said.
To get a hydrant marker install in Rochester, clear your hydrant three feet in all directions and call Rochester Public Utilities.
Hannah Tiede
Created: February 27, 2019 05:47 PM


I went on "Lowdown with Lowetide" on TSN 1260 Edmonton with my friend Allan Mitchell today to talk about Jimmy Vesey and his decision not to sign with the Nashville Predators after a stellar Harvard Crimson career. Instead, he'll focus on finishing his coursework and graduate with his Harvard classmates in the coming weeks. On August 15, if nothing changes, he'll then become a free agent and open to signing with any of the other (presumably) 29 teams.
Allan aka Lowetide is an Edmonton Oilers guy (obviously) but prior to that, he was a Boston Bruins fan in the great Big Bad Bruins days of Bobby and Phil, Gerry and Chief, EJ and Turk, Don Awrey and Ken Hodge… Eddie Westfall and Terrible Ted and…well- you get the idea. He keeps tabs on the B's and is kind enough to often times let me come on his show to be the voice that brings folks up to speed with the team.
Today, the focus was not on the B's but on a Boston guy- North Reading's own Jimmy Vesey. It's a relatively short segment- I have a much longer and more comprehensive podcast coming to the blog later on, but this should whet the whistle a bit.
My thanks again to Al and his producer, "Lieutenant Eric"- both good blokes who host a fine show for the nice people in Edmonton.


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Provider Relief Fund Update: Use of Funds Deadline, Portal Registration, Reporting Entities
On June 11, 2021, the Department of Health and Human Services (HHS) announced the Provider Relief Fund (PRF) portal will open for reporting on July 1, 2021. Any provider that received and retained payments exceeding $10,000 in aggregate on or before June 30, 2020, must use those funds by June 30, 2021, and complete the reporting process by September 30, 2021.
HHS promises to hold webinars, update and issue additional Frequently Asked Questions, and publish a detailed reporting portal user guide. However, HHS has not provided a date by which such guidance will be available.
The clock keeps ticking on the first deadline: use of funds by June 30, 2021. Despite pleas from members of Congress, trade associations, and provider organizations, HHS refused to extend this deadline for funds received before July 1, 2020.
One of the most common questions we're asked is whether assuming an obligation to make payment at a future time constitutes "use of funds." For example, we've heard from several organizations that want to use PRF dollars to make facility modifications to provide more appropriate care for potentially contagious individuals. Due to labor shortages and supply chain interruptions, however, it is not possible to complete the work by June 30, 2021.
To date, HHS has not squarely addressed this issue. Its guidance has used the terms "expense," "expenditure," and "use" interchangeably although each has a different meaning for accounting purposes. This has left some providers hesitant to commit PRF dollars to projects that will not be fully completed by June 30, concerned that HHS will demand recoupment of any amount paid after that date even if the provider had a contractual obligation to make such payment.
Our team has had several spirited discussions on this subject, doing our best to play devil's advocate. Based on HHS' guidance that providers "must follow their basis of accounting (e.g., cash, accrual, modified accrual) to determine expenses," we have concluded that a provider using an accrual method of accounting can include any amount it recognizes as an expense—even if payment is not due until after June 30—as an appropriate use of PRF dollars (provided, of course, the use of funds is attributable to coronavirus). For those providers operating on a cash basis, we are not as confident in our response, but we still believe HHS should conclude such use of funds is appropriate in these circumstances. In both cases, the provider should thoroughly document the reasons for the delay.
HHS' Provider Relief Fund FAQs address the use of funds and reporting requirements for providers having experienced changes in ownership both before and after having received PRF payments. Those providers that have been involved in such transactions should study this guidance carefully to determine parties' respective duties. Although the FAQs include multiple scenarios, one matter not addressed is the use of funds by and reporting for a tax identification number (TIN) that has ceased doing business. Hopefully, HHS will address this specific issue in subsequent reporting guidance.
The Provider Relief Fund portal has been open since January 15, 2021, but only for registration. We know many providers that have been waiting to complete the registration process, hoping for additional guidance from HHS regarding reporting entities. Given one will not be able to access the reporting screens without having first registered, now is the time to complete that process, incorporating the guidance on parent/subsidiary reporting options based on your reporting strategy.
Importantly, a parent entity reporting on behalf of its subsidiaries must submit a complete list of the subsidiary TINs delimited by commas. As explained in the June 11 Post-Payment Notice of Reporting Requirements, HHS will permit a parent entity to include its subsidiaries' General Distribution payments in its reporting, but a parent entity may not include its subsidiaries' Targeted Distribution payments. Instead, the original recipient of a Targeted Distribution must report on the use of funds under its own TIN, regardless of whether the original recipient subsequently transferred the payment.
HHS has updated the user guide and detailed FAQs regarding the registration process as of June 11. HHS warns the process will take at least 20 minutes and must be completed in one session (i.e., one cannot save partial information). The system will timeout after 15 minutes of inactivity, forcing the user to re-start the process from the beginning. The user guide includes screenshots detailing all information required to complete the registration process.
PYA's COVID-19 Task Force includes subject matter experts in regulatory compliance, accounting, audit, cost reporting, tax, operations, and strategy. We help health systems, hospitals, critical access hospitals, post-acute providers, and physician practices of all specialties navigate COVID-19 relief funding. Our team's numerous presentations and publications have delivered direction and insight for providers struggling with complex, confusing, and sometimes contradictory federal guidance.
As your organization prepares to register and report, PYA can help with:
Developing a defensible lost revenue calculation
Re-allocating targeted distributions
Interpreting and applying guidance regarding coronavirus-related expenses
Properly accounting for other coronavirus relief
Developing appropriate documentation in the event of future audit
Addressing coronavirus-related cost reporting issues
Understanding and preparing to meet Single Audit requirements
If you would like guidance related to the appropriate use of Provider Relief Funds, or for assistance with any matter related to COVID-19 relief, visit PYA's COVID-19 Hub, or contact one of our PYA executives below at (800) 270-9629.
HHS Releases Updated Provider Relief Fund Reporting Requirements; Sets September 30 Reporting Deadline for Most Recipients
PYA Short Course Webinar Series Provides Critical Information on the Consolidated Appropriations Act


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Top 50 In Global Pharma By 2025 -- Luye Pharma Group Announces "Whole Value Chain" Global Collaboration Strategy
PR Newswire Asia
HONG KONG, June 25, 2018 /PRNewswire/ -- On June 22nd in Hong Kong, Luye Pharma Group hosted a conference to unveil their Global Collaboration Strategy. Liu Dianbo, Chairman of Luye Pharma Group, said at the event, "Starting in 2019, Luye Pharma will gradually begin to enter into a period of harvest, with past work coming to fruition, the company plans to launch at least one new drug every year. At the same time, we are also making comprehensive plans for the company's development over the next five to ten years. We will pursue global partnerships in three strategic areas - global R&D, global manufacturing and global marketing, to ensure the company's goal of becoming one of the world's top fifty pharmaceutical companies by 2025."
The focus of the conference was on Luye Pharma's "Whole Value Chain Global Collaboration" strategy, proposed by Liu Dianbo. This is the first time that Luye Pharma has released their official global collaboration strategy to the public:
From innovation, R&D and manufacturing to marketing and distribution, Luye Pharma is committed to close collaboration with global business partners to best leverage the resource advantage of every party in the entire industry value chain, to better serve patients worldwide.
Jiang Hua, Vice President, Strategy & Business Development at Luye Pharma Group, also discussed the strategic thinking behind the company's recent acquisition of AstraZeneca's Central Nervous System (CNS) products, Seroquel (quetiapine fumarate, immediate release, IR) and Seroquel XR (extended release formulation) in 51 countries and regions. Mr. Simon Mellon, Consul for Trade and Investment at the British Consulate General in Guangzhou and Assistant Director for Life Sciences, Health and Social Care for South China at the Department for International Trade, as well as Mr. Chen Bing, Vice President of Alliances & Business Development at AstraZeneca also attended the conference.
Global R&D: Strengthen the advantages of four innovative technology platforms and make comprehensive plans for development of new tech areas
Luye Pharma has always been focused on the development and manufacturing of innovative drugs, and has set up R&D centers in Europe, the United States and China. To integrate its global R&D resources, Luye Pharma follows a strategy of independent R&D augmented by external collaboration. The company to date has developed four innovative technology platforms; advanced drug delivery systems, new antibodies, structurally optimized small molecules, and cell & gene therapy, in addition to multiple existing collaborative agreements with leading biotechnology companies.
Luye Pharma' s "advanced drug delivery systems" represent the company's unique competitive advantage in the R&D field, an area Luye has been relentlessly pursuing for many years. The company's microspheres, liposomes and transdermal drug delivery technologies are at an advanced international standard. Risperidone Extended Release Microspheres (LY03004), which was developed by Luye Pharma for the treatment of schizophrenia and bipolar disorder, has reached the NDA (new drug application) stage in the United States. Rotigotine Extended Release Microspheres (LY03003), indicated for Parkinson's disease, have begun Phase III clinical trials. "These new drugs will go on the market one by one, starting from 2019, in countries and regions around the world, something of a harvest period for Luye" said Jiang Hua. "In addition to independent research and development, we will also seek external collaboration to strengthen the four major existing innovative technology platforms and to facilitate our forward-looking deployment for the next generation of innovative drugs."
Since last year, Luye Pharma has been deploying its resources in multiple areas through a number of R&D collaboration projects, including novel target antibodies, protein drugs, immuno-oncology, cell therapy, and smart precision drug delivery systems. In August 2017, Luye Pharma acquired two monoclonal antibody drugs from Shandong Bo'an Biotechnology Co., Ltd. (LY01008 and LY06006), and obtained a "biological antibody technology" R&D platform. The two drugs have already started Phase III and Phase I clinical studies, respectively. At the end of 2017, Luye Pharma made an equity investment in Exicure Inc., a US-based biotechnology company. Exicure's SNA technology will synergize with Luye Pharma's established liposome and microsphere delivery technologies in discovering novel nucleic acid drugs for use in oncology and other areas of unmet needs. In the field of immuno-oncology, Luye Pharma has successively built strategic collaborations with three leading U.S. biotechnology companies - ABPRO, Excel Biopharm LLC and ELPIS BIOPHARM, to jointly develop novel bispecific antibodies, therapeutic antibodies for the next generation of immuno-oncology and CAR-T therapy, among others.
Global Market: To develop product pipelines with global competitiveness in core therapeutic areas
CNS, oncology, cardiovascular, and metabolism are Luye Pharma's four core therapeutic areas of long-term focus, with Luye making a series of systematic and sustainable plans aimed at developing these areas. With the acquisition of Acino's transdermal patch and implants business, as well as a number of new drugs independently developed by the company, Luye Pharma has been able to build a wealth of CNS product pipelines and therapeutic solutions. In addition to Risperidone Extended Release Microspheres (LY03004) and Rotigotine Extended Release Microspheres (LY03003), Ansofaxine Hydrochloride Extended Release Tablets (''LY03005'') for the treatment of depression have also entered into Phase III clinical trials. New drug development projects such as Rivastigmine Multi-day Transdermal Patch (30410) for the treatment of mild-to-moderate Alzheimer's disease is also progressing smoothly. The recently acquired Seroquel and Seroquel XR from AstraZeneca is another blockbuster added to Luye Pharma's CNS portfolio.
Seroquel and Seroquel XR are atypical anti-psychotic medicines with antidepressant properties. The main indications for Seroquel are the treatment of schizophrenia and bipolar disorder. Seroquel XR is also approved in some markets for major depressive disorder and generalized anxiety disorder. Because of their fast onset, good tolerability and high patient compliance, Seroquel series products are widely recognized by doctors and patients, and are currently marketed in more than 80 countries around the world, with the total number of prescriptions exceeding 10 million.
In accordance with the acquisition agreement, Luye Pharma will acquire the assets of Seroquel and Seroquel XR in 51 countries and regions including China, the United Kingdom, Brazil, Australia, Saudi Arabia, Mexico, Thailand, Argentina and Malaysia, as well as other countries and regions in Asia, Latin America, Africa, Oceania and Eastern Europe. The assets include marketing authorization, regulatory information, certain patents, relevant business materials and data, manufacturing know-how and sales networks, among others. In addition, AstraZeneca has agreed to grant exclusive, permanent, free and sub-licensable trademark licensing, along with other licensing rights, to Luye Pharma.
"In addition to our optimistic outlook about the business performance and growth potential of the Seroquel products, the deal was made to generate market synergy for Luye and to pave the way for the launch of other CNS products in global markets", said Jiang Hua.
Seroquel and Seroquel XR can complement Risperidone Extended Release Microspheres (LY03004) and Ansofaxine Extended Release Tablets (LY03005) in both domestic and overseas markets, as they can serve the same patient population and there is no exclusive competition when these drugs share channels and promotional resources. Seroquel and Seroquel XR can also contribute, with their readily available domestic and international commercial resources, to the launch and accessibility of new CNS drugs, such as Risperidone Extended Release Microspheres (LY03004) and Rotigotine Extended Release Microspheres (LY03003), as well as comprehensively enhance the global competitiveness of Luye Pharma's CNS portfolio.
"In the future, we hope to build and expand pipelines featuring global competitiveness in another three core therapeutic areas including oncology and cardiovascular, and we also look forward to continuing our comprehensive and in-depth strategic collaboration with our partners via out-licensing and in-licensing", Jiang Hua added.
Global Supply Chain: Covering upstream raw material procurement right through to patient supply
Luye Pharma is combining its seven global sites into a global manufacturing platform to tap the overseas markets, and hopes to graft the relatively mature local industrial chains into the global advanced supply chain via means including raw materials procurement and CMO partnerships. The goal is to establish a global supply chain network covering everything, from raw materials procurement right through to patient supply.
It is worth mentioning that as a result of the acquisition of Seroquel products, production technology for the two drugs will be transferred to Luye Pharma upon completion of the initial payment to AstraZeneca. The Seroquel series products, especially Seroquel XR, has a very advanced production processes. Luye Pharma plans to introduce these technologies to China shortly after the acquisition, which will also be the first time that the production technology for Seroquel XR comes to China. Shandong Luye Pharmaceutical Co., Ltd. will be the future production base for the global supply of the Seroquel series, not only strengthening the production capacity of new formulations, but also allowing for further alignment with the global production quality system.
"On its path of global development, Luye Pharma has been actively seeking the best M&A opportunities with respect to the different components in the entire value chain, such as R&D, production, and distribution. We look forward to working with our global partners to complement each other and achieve win-win collaborations. We also hope to tap into new and more sustainable growth drivers for the company through a variety of extensive development models and further enhancements to the company's core competitiveness in the global market," Liu Dianbo concluded.
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Forbidden City sparks fury after allowing pair to flout car ban


As the Internet of Things (IoT) expands toward 21 billion devices in 2020, the volume of location data, along with all other data types, will only increase.
The move toward a world of connected cars, smart devices, and intelligent sensors will create high-value markets focusing on spatial analysis and geo-analytics. After all, this is the key premise of IoT: linking devices, humans, and networks all together to give consumers more knowledge and control.
Let's remember that geo-analytics is not just the holy grail of our "Internet of everything" future. In the past couple of years, the insight value of location data has been extremely important to many other business verticals.
Take, for example, location-based targeting in advertising: Juniper Research predicts that revenue generated by location-based services will reach $43.3 billion by 2019.
This will drive the introduction of more intelligent devices, vehicles, and sensors that produce data at a much higher rate than we have ever seen; nearly all of that data generated will have a spatial element to it.
Today's market leaders are using geospatial analytics to draw location-based insights and optimize workflows, reduce costs, manage risk, and optimize the customer experience.
Financial services. Fraud detection is a billion-dollar problem in finance, affecting consumers and banks alike. Geospatial data can help financial institutions detect and prevent fraud by correlating spatial, temporal, and transactional data altogether using predictive analytics and anomaly-detection techniques.
Retail. In the age of omni-channel retailing and hyper-personalization, geospatial is the missing link that provides customers with a seamless and converged experience between offline channels (in-store purchases, smart tags) and online channels (web, mobile).
Adding geospatial analytics to the personalization across channel interactions can help retailers optimize their promotional activity based on customer locations.
Insurance. High quality geospatial data is critical to the insurance industry, as risk is often tied to location. Insurers can perform risk simulations against vast amounts of data to come up with the right risk model.
This helps insurers better estimate potential losses and help customers to purchase the correct amount of cover at the right price.
While the above applications of geospatial intelligence seem diverse by virtue of business vertical, they all share one common trait: the value of their generated data is perishable within seconds, if not less.
It goes without saying that, for location information to be valuable, it must be processed immediately. A financial services firm cannot effectively implement fraud-detection mechanisms based on location by having an insight-to-action time frame that exceeds minutes; it will suffer major financial losses if the data is not captured and acted upon immediately.
The emergence of IoT, mobile, and geo-analytics has driven most database vendors toward enabling geospatial analytics across their products. However, it is quite difficult to implement high-performance geospatial analytics on relational databases that were not built for these workloads.
We can't simply introduce another layer of abstraction to circumvent the impedance mismatch between relational databases and high-throughput geospatial data processing applications.
What we need is the ability to ingest, consume, and analyze billions of location data points and seamlessly execute continuous real-time queries against them to generate contextual insights at global scale.
In-memory computing is creating an opportunity for organizations to be highly competitive in processing fast data and streaming analytics at scale, while reducing the cost to design, build, deploy, and support complex data pipelines.
In particular, in-memory computing has the ability to fundamentally change the way geospatial intelligence is processed and consumed by providing real-time and continuously updated insight into everything that is happening in the field at low latency.
In a time of increasing data generation in the physical world, in-memory computing directly addresses the need for low-latency communication between the data center and the edge. Because in-memory computing consolidates the storage of data in RAM with the processing of business logic in the same runtime space, geospatial analysis with feedback to edge devices, at very high throughput, can be accomplished in milliseconds, as opposed to the minutes or hours it traditionally takes.
Data storage. In-memory data grids are graph-driven, which is a model better suited for geospatial data than are relational databases.
Performance. Memory is about 58,000 times faster than disk, so as geographic data is generated, insights can be extracted at millisecond and microsecond latencies.
While having the infrastructure that can capably deal with all of the data generated in a full-fledged geospatial scenario is crucial, of equal importance is having the ability to analyze it at millisecond latencies and turn it into something of value to both the consumer and the organization.
Here, in-memory geospatial analysis (geo-fencing, predictive modeling, equipment tracking) can connect insights into workflows and actions to trigger business outcomes, alerts, and machine-to-machine automation.
In-memory computing provides a new powerful paradigm for analyzing massive streams of geospatial data at millisecond scale and is the most appropriate fit for geospatial analytics. This is true just-in-time geospatial intelligence.


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Ladakh Tour 4 Days
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Destination Covered : Leh Ladakh
Highlights : Magnetic Hill, Gurudwara, Leh surroundings and Jeep safari to Pangong Lake on Indo-China border.
Day 1: Arrival Leh
Arrival Leh, Browse Ladakh representative will meet, greet, assist and transfer you to Hotel in Leh. Rest of the day free to acclimatize to the high altitude of Ladakh. In the evening take a walk to the local bazaar in Leh. Overnight at Hotel in Leh.
Day 2: Sightseeing around Leh (90 Kms round trip)
Day 02 : Sightseeing around Leh (90 Kms round trip)
Morning after breakfast visit Hall of Fame, Spituk Monastery and Kali Mata Temple, Magnetic Hill, Gurudwara Patthar Sahib and Confluence of Zanskar - Indus rivers. Return to Leh for lunch (on own). In the evening visit Leh Palace, Donkey Sanctuary and Shanti Stupa for beautiful sunset view. Dinner and overnight stay at the hotel in Leh.
Ladakh Hall of Fame : The Hall of Fame is a glorious museum constructed by the Indian Army. It is worth a visit for every citizen. You can see the memorabilia, eminent defense personalities with biographies, images and weapons used during the Kargil and other key strategic battles fought in Ladakh. And belongings of the enemy soldiers found at war site. All the martyr and the gallantry awards. Here's something that you will be proud of our defense personnel who sacrificed themselves so that we could live in peace.
Spituk Gompa : 8 Kms from Leh, it stands prominently on the top of hillock commanding a panoramic view of the Indus Valley for miles. Many icons of Buddha and fine Thankas are to be found in this 15th century Gompa. The Gompa also houses a collection of ancient masks, antique arms, and an awe-inspiring image of Mahakaal. The face of the Kali image is kept covered and is revealed only at the annual function at January every year.
Magnetic Hill : Defying the Law of gravity. This place is close to the Gurdwara Shri Patthar Sahib. It has been noticed that when a vehicle is parked on neutral gear on this metallic road the vehicle slides up-hill that's the Believe it or not of Ladakh!
Gurdwara Shri Patthar Sahib : Situated 25 miles from Leh, Gurudwara Pathar Sahib stands at the place where Guru Nanak, the founder of Sikh religion and the first guru, is believed to have vanquished a demon. According to legend, during his sojourn in Ladakh, Guru Nanak was attacked by a demon. The demon threw a large boulder on the guru as he sat at the base of a hill meditating. However, the rock became soft like molten wax and failed to cause any harm to the Sikh guru. The demon was in for a surprise when he found the Sikh guru unscathed. Bristling with fury, the demon tried to crush Guru Nanak by kicking the boulder with all his might. To his surprise, the demon's foot caused a deep impression in the boulder which had turned soft. Realizing that the man in front of him was no mortal soul, the demon underwent a transformation and stopped harassing the people. The boulder with the imprints of Guru Nanak Dev Ji and the foot of daemon still rests there. The gurudwara is maintained today by the Indian Army. It is a tradition for vehicles to stop and pay obeisance at the temple.
Conflence Of The Zanskar & Indus : On way to Sham Valley before Nimu village one can have this magnificent view of two rivers in wed-lock! In seasons they have different colors and flow and wildness.
Donkey Sanctuary : The sanctuary is situated just off the road leading to Khardungla Pass. The public is encouraged to visit the sanctuary and friendly signs will direct you to the sanctuary from the center of Leh. Once at the sanctuary, the artistic surprise awaiting you is well worth the effort. It is open to the public throughout the day and donations and juicy carrots are most welcome and used exclusively for improving the lives and welfare of these wonderful animals.
Leh Place : The Palace overlooks Leh town and is modeled on the Potala Palace in Lhasa, Tibet. The palace was built by King Sengge Namgyal in the 17th century, but was later abandoned when Dogra forces took control of Ladakh in the mid-19th century. The royal family moved to Stok Palace. Leh Palace is nine storeys high; the upper floors accommodated the royal family, the stables and store rooms were in the lower floors. The palace, a ruin, is currently being restored by the Archaeological Survey of India. The palace is open to the public and the roof provides panoramic views of Leh and the surrounding areas. The richest collection of jewellery, ornaments, Thangkas, ceremonial dresses, crowns, and centuries-old pieces of jewellery are kept here for public display. There are Chinese Thangka or sooth paintings which are more than 450 years old but still look new.
Shanti Stupa (Japanese Peace Pagoda) : Shanti Stupa/Japanese peace pagoda is build by a Japanese religious organization headed by Head monk Nakamura with the help from the organization and local people. It is situated at a hill top in Cahngspa village providing a bird eye view of the Leh town and the surrounding mountain peaks. Architecturally it has the Japanese touch with small clean rooms on the side for meditators and the main Japanese shrine at the entrance.
Day 3: Excursion to Pangong Lake (280 Kms round trip)
Morning after breakfast drive to to Pangong Lake on the Indo China border. Evening back to hotel in Leh for dinner and overnight.
The Pangong Lake : This route takes the visitor past the picturesque villages of Shey and Thiksey, and turns off the Indus valley by the side valley of Chemrey and Sakti. The Ladakh range is crossed by the Chang-la (18,000 feet / 5,475 M) which despite its great elevation is one of the easier passes, remaining open for much of the year even in winter, apart from periods of actual snowfall. Tangse, just beyond the foot of the pass, has an ancient temple.
But the main attraction of this circuit is the Pangong Lake, situated at 14,000 feet (4,267 M). A long narrow basin of inland drainage, hardly six to seven kilometers at its widest point to which foreigners are permitted, is only some seven km along the southern shore from the head of the lake, but it affords spectacular views of the mountains of the Changchenmo range to the north, their reflection shimmering in the ever-changing blues and greens of the lakes brackish water. Above Spangmik are the glacier and snow-capped peaks of the Pangong range.
Day 4: Airport Departure
Leave on time for Leh airport to board your flight to Delhi.
EP (No Meal)
Some Advance Percentage of total booking amount
Airfare/Transport fare to be paid full at one time in advance.
Upon cancellation, refund will be made after deducting the Retention Amount.
Retention Amount varies as per the number of days left before your package start date.
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The Human Environments Analysis Laboratory is a state-of-the-art, inter-disciplinary research and training environment which specializes in the production, evaluation, synthesis, dissemination and mobilization of evidence to support effective policies, programs and professional practice aimed at creating healthy and vibrant communities. We examine social and physical environments from the scale of entire regions down to the level of individual buildings or open spaces and their inhabitants. We specialize in community-based participatory research and applications of GIS for urban planning and public health.
The HEAL develops and connects highly-skilled researchers to create, disseminate, and mobilize knowledge for making healthy, thriving communities.


If you are looking for the "Raiders" hat or just a great hand made custom fedora the Adventurebilt is for you. In this age of mass produced product, it's hard to find something made with such care and attention to detail as the adventurebilt. The quality of his product is equal only to his great customer serves. I can't say enough about Steve Delk and his Adventurebilt fedora.


To paraphrase the character of Tevye in Fiddler on the Roof, "On the one hand it seems odd to pay to tribute to performers I never got to see perform; on the other hand, it does not seem fair to leave them off the list just because they performed before I was born; on the other hand, who am I to judge who was great or not, because as the good book says..." Wait, the good book does not say anything about this.
This section pays tribute to many of the legendary theatre performers. Some I have been fortunate enough to live, some I have seen on film, and some I wish I could have seen, but they all have contributed to the musical theatre.
Al Jolson: A veteran of vaudeville, he starred in Robinson Crusoe Jr., Sinbad, and Big Boy, among others, on Broadway. His blackface act was popular in its day and grew in disfavor when blackface became politically incorrect; however, as a Lithuanian Jew, Jolson had no love of prejudice and fought for black performers and playwrights on the Broadway stage. He starred in the first talking picture, the musical The Jazz Singer.
Alan Alda: Best known as Hawkeye on the TV show, MASH, but before that he was a Broadway actor in the musical The Apple Tree and was cast in at least 5 other shows. He performed in 5 more stage shows since 1992.
Angela Lansbury: A favorite of Stephen Sondheim, her musical credits include, Anyone Can Whistle, Mame, Dear World, Sweeney Todd, and in revivals of Gypsy and A Little Night Music. She, of course, has performed in a variety of plays, movies,and TV roles, most notably Murder She Wrote.
Ann Reinking: With supporting roles in Pippin and Caberet, she had leading roles in Over Here and Goodtime Charley before replacing Donna McKechnie in a Chorus Line and then Gwen Verdon in Chicago and his performed in many other musicals.
Audra McDonald: Having won 3 Tony Awards by the age of 28, including for her role in Ragtime, she has been working steadily on Broadway and in concert since 1994. Her latest role is in the revival of Porgy and Bess.
Barbara Cook: One of the most popular stars of the stage in the 1950's, she starred in Candide and The Music Man, and has continued to perform in a wide variety of musicals and concerts ever since.
Bebe Neuwirth: Best known as Lilith on the TV show Cheers, she has starred in revivals of Sweet Charity and Chicago. She has done a one woman cabaret shows that was entitled Bebe Neuwirth and played Morticia in The Addams Family.
Ben Vereen: A true triple threat, he starred in Pippin as the Leading Player and in Jesus Christ Superstar as Judas, and has performed in many other stage and screen musicals.
Bernadette Peters: While her movie and television appearances would be enough for a full career, she is beloved on Broadway. Her stage shows include Mack and Mabel, Sunday in the Park with George, Song and Dance, Into the Woods, and revivals of Annie Get Your Gun, Gypsy, On The Town, A Little Night Music, and most recently, Follies.
Bert Lahr: An actor, comedian, singer, and dancer, Bert Lahr came up in vaudeville and burlesque, he performed in at least 16 Broadway musicals. His shows include Hold Everything, Flying High, DuBarry Was a Lady, and George White's Music Hall Varieties. He is best known as The Cowardly Lion in the movie The Wizard of Oz.
Bill "Bojangles" Robinson: One of the great tap dancers of all time, Mr. Bojangles started dancing professionally as a child and came up through vaudeville. On Broadway, he starred in Blackbirds of 1928, The Hot Mikado, All In Fun, and Memphis Bound.
Bob Hope: From vaudeville to radio to movies to television, Bob Hope was one of the greatest entertainers in history. In the late 1920's through the mid 1930's, he performed on Broadway in shows that included Sideways of New York, Red Hot and Blue, Roberta, and the Ziegfeld Follies of 1936.
Bobby Van: A star of MGM movie musicals, he was on Broadway in the 1971 revival of No No Nanette, the 1954 revival of On Your Toes, as well as Alive and Kicking and Doctor Jazz.
Carol Burnett: As Princess Winifred in Once Upon A Mattress, Carol Burnett had a huge Broadway hit. Among her other musicals were Fade In Fade Out and Putting It Together. She became beloved across America with her TV hit The Carol Burnett Show that included Broadway style musical features. She continues to perform and has is also an author.
Carol Channing: Best known for her starring role in the original Broadway production of Hello Dolly, Carol Channing has performed on stage and screen for over half a century. She originated the role of Lorelei in the stage version of Gentlemen Prefer Blondes. Ms Channing won a Tony Award for Hello Dolly and was nominated for four other roles.
Chaim Topol: Often known simply by his last name, this Israeli actor starred as Tevye in the West End production of Fiddler on the Roof and then was nominated for an Oscar for the the role in the movie version. He later reprised the role in revivals on Broadway, the West End, and on tour.
Chita Rivera: Chita Rivera has had a long career on the stage, originating the roles of Anita in West Side Story, Rosie in Bye Bye Birdie, Velma Kelly in Chicago, Anna in The Rink, and Aurora in Kiss of the Spider Woman. She won Tony Awards for last two roles. Her screen credits include roles in Sweet Charity and Pippin.
Christine Ebersole: Tony Award as Dorothy Brock in the 2001 revival of 42nd Street and Edie in Grey Gardens.
Fanny Brice: A comedienne, singer and actress, she performed on film, radio, and the stage. The musical Funny Girl was (rather loosely) based on her life . She started in burlesque and appeared in nine years of the Ziegfeld Follies, as well as The Honeymoon Express and Nobody Home..
Gene Kelly: He was a starred on Broadway as Joey Evans in Pal Joey in 1940 and then the choreographer of Best Foot Forward before leaving Broadway to become a Hollywood legend. He returned to Broadway to direct Flower Drum Song.
Kristin Chenoweth: One of the most prolific actresses in recent years, she has starred in Wicked and a revival of Promises Promises, in addition to playing Sally in You're a Good Man Charlie Brown. She is also a veteran recording artist and has appeared on film and TV.
Lauren Bacall: Best known for her movie roles, especially those with her husband, Humphrey Bogart, she has acted in six Broadway plays, two of which were musicals. She starred in Applause as Margo Channing with a cast that included Ruby Keeler and Bonnie Franklin, among others.
W.C. Fields: An actor with great comedic skills, he started in as an juggler in vaudeville and also performed in silent and talking movies as well as radio. On Broadway, he was featured entertainer in the Ziegfeld Follies for six years and starred in the musical comedy Poppy.
Williams Daniels: Successful on stage and on TV, his Broadway musical credits include A Thousand Clowns and On A Clear Day You Can See Forever. His best role was as John Adams in 1776, first on stage and then in the movie version.
Yul Brynner: His best known role was as Mongkut, the king of Siam, in the King and I in both the Broadway and movie versions of the show, he acted from 1941 - 1985.
Zero Mostel: Best known for his original comic roles on Broadway as Tevye in Fiddler on the Roof and Pseudolus in A Funny Thing Happened on the Way to the Forum, he was also a mainstay of stage and screen in the 1960's and 70's.


This beautiful brick and stucco Tudor is located in the heart of the desirable Colonial Village neighborhood. Close to all the action - walking distance to ISU campus, Jack Trice and Hilton Coliseum. Beautiful attention to details - original hardwoods, marble tile foyer, original 1930's tile in excellent condition. Brand new kitchen with gas stove and Fisher & Paykel appliances for you to entertain guests and prepare gourmet meals. The wood burning fireplace adds warmth and charm to this 1930's gem. Three bedrooms, 1.5 bathrooms and a circular floor plan will draw you in. Main level also has a study/den with stone floor and French doors, with private entrance. Beautiful, fully enclosed backyard and patio; with 2-car detached garage. Do not miss this opportunity to own this gorgeous home!


In 2009, Tomi and Forrest Madden journeyed from their Montana home to Nebraska for the great Sandhill Crane migration in the Platte River Valley. Each year, the valley swells with hundreds of thousands of cranes. The Maddens watched countless beating wings fill the sky and heard a chorus of calls echo throughout the valley where the cranes find nourishment and protection en route to northern nesting grounds.
It was spring, and Forrest Madden was battling prostate cancer.
"Forrest loved the birds," said Tomi. "He had three weeks off of chemo treatments, so that's where we went." Twenty boxes of brightly-colored origami paper went with them.
During their Nebraska visit, Tomi folded and shaped 1,000 origami cranes, creating a brilliant mobile of reds, greens, blues and yellows. Cranes are a significant symbol in Japanese culture, Tomi's heritage. Traditionally, they represent hope, strength and bring luck that carries the promise of longevity, fidelity, prosperity or happiness. An ancient Japanese legend pledges that anyone who folds 1,000 origami cranes will be granted a wish, or will heal from injury or illness.
Tomi hung her mobile in Montana Cancer Center (MCC) at Missoula's St. Patrick Hospital where Forrest received treatment. Forrest's nurse at MCC was Teresa Snyder.
Tomi Madden fold paper cranes together.
Forrest passed away in August, 2011. Tomi volunteers at the hospital that cared for her husband. She and Teresa don't see each other as often as they used to, but when they do, they receive one another as old friends. Tomi's 1,000 cranes are still displayed just inside the doorway of the MCC's Treatment Center where they greet dozens of patients each day.
"People walk in and are immediately taken in by the color," said Teresa. "They can't help but touch it." The cranes invite conversation and consistently spark the story of Nebraska's wildlife-rich river valley, Japanese legend and healing.


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The DASH-Sodium study was conducted following the end of the original DASH study to determine whether the DASH diet could produce even better results if it were low in salt and also to examine the effects of different levels of sodium in people eating the DASH diet.[2] The researchers were interested in determining the effects of sodium reduction when combined with the DASH diet as well as the effects of the DASH diet when at three levels of sodium intake. The DASH-Sodium trial was conducted from September 1997 through November 1999. Like the previous study, it was based on a large sample (412 participants) and was a multi-center, randomized, outpatient feeding study where the subjects were given all their food.[12] The participants were adults with prehypertension or stage 1 hypertension (average systolic of 120 to 159 mm Hg & average diastolic of 80 to 95 mm Hg) and were randomly assigned to one of two diet groups.[10] The two randomized diet groups were the DASH diet and a control diet that mirrored a "typical American diet", and which was somewhat low in key nutrients such as potassium, magnesium and calcium. The DASH diet was the same as in the previous DASH study. After being assigned to one of these two diets, the participants were given diets that differed by 3 distinct levels of sodium content, corresponding to 3,000 mg, 2,400 mg or 1,500 mg/day (higher, intermediate or lower), in random order, for 30 consecutive days each.[10] During the two-week run-in phase, all participants ate the high sodium control diet. The 30-day intervention phase followed, in which subjects ate their assigned diets at each of the aforementioned sodium levels (high, intermediate and low) in random order, in a crossover design.[12] During the 30-day dietary intervention phase, each participant therefore consumed his or her assigned diet (either DASH or control) at all three sodium levels.[dubious – discuss]
When you're headed to the market, make sure to focus on the usual healthy fare, since you'll need at least a week's worth of food. But for the planned meals specifically, here's what you'll need to add to your 3-day military diet shopping list: 1 grapefruit, 4 slices of whole-wheat toast, 3 eggs, 2 cups of coffee, 11/2 cups tuna, 2 tbs peanut butter, 3 oz meat, 1 cup green beans, 2 bananas, 2 small apples, 2 1/2 cup vanilla ice cream, 1 cup cottage cheese, 10 saltine crackers, 2 hotdogs, 1 cup broccoli, 1/2 cup carrots, and 1 slice cheddar cheese. Chances are, you have a lot of this already in your kitchen.
On the South Beach Diet, there are good carbs and fats, and there are bad carbs and fats. The key to weight loss is choosing the best of each. That means lots of vegetables, fish, eggs, dairy, lean protein like chicken and turkey, whole grains and nuts. South Beach is lower in carbohydrates and higher in protein and healthy fats than the typical American diet.
Here we present a case of hyperglycemic ketoacidosis associated with a low carbohydrate diet. The South Beach Diet is a popular diet plan which primarily relies on the restriction of dietary carbohydrates to achieve weight loss [1]. Our patient strictly adhered to 10 to 15 grams of carbohydrate per day for 3 weeks prior to presentation and lost 16 pounds. He was following the most stringent form of this diet, namely that being the form in which total carbohydrate consumption is limited to less than 20 grams daily. On presentation, our patient was felt to be in diabetic ketoacidosis but, interestingly, the patient was subsequently euglycemic without therapy and, even after two years of follow up, remained asymptomatic and euglycemic.
The Military Diet's focus on small quantities of high-fat food might leave you feeling hungry, too. "This is allowing a very little bit of rich food," explains Gomer, noting that you'll still feel hungry despite indulging in ice cream each night. "It makes me frustrated because I could give people six times the amount of food [for the same amount of calories]," says Gomer.
Nine most popular diets rated by experts 2017 There is a wide variety of diets for losing weight, gaining weight, or living healthily. This article looks at nine of the most popular diets based on how many articles cover them, how popular they are, and how much feedback we receive about them. Diets include the ketogenic diet, the Zone diet, and the raw food diet. Read now
Sheila stakes out Boone's house while Joel goes undercover at Japopo's but Joel is recognized for writing a negative Yelp review. The proprietor agrees to give Joel their receipts if he writes a positive review. Sheila accidentally convinces Anne to investigate the recent murders herself and Joel encourages Sheila to end their friendship. Sheila and Joel voice concern for Abby before renting a second storage unit; one for Gary and the ball creature, and the other for a kill room. Ron finds Joel and Sheila at work and Joel persuades him to keep their secret. Principal Novak nearly gives Abby a month's detention but with Eric's intervention, she instead joins the Environmental Club. Abby meets a new boy, Sven. Sheila and Joel lure Boone to their storage unit. She kills him as well as his fellow Nazi friend. Abby ditches the Environmental Club for something more extreme, with Eric's support. Joel vents to Gary and writes a new review for Japopo's. At the restaurant, Ron meets with the couple from Goran's apartment, Marsha and Paul. They are looking for Serbian bile and information on the Hammonds. The man sports a ball creature tattoo on his arm.
Dairy has never been a staple of my diet. I eat cheese only occasionally, and I don't really crave it like many people do. Low-fat dairy plays a central role in reaping South Beach Diet results, and I was game to try out eating it for two weeks, but it just cemented for me that yogurt is bland and horrible—and in no way filling or satisfying. But what I really couldn't get down with were the cheese swaps.
In most zombie stories, the fact that Joel still loves Sheila after she turns would ultimately lead to his gory death. In Santa Clarita Diet, though, the invaders with their odd dietary customs aren't monsters. They're family. Even in the face of a zombie apocalypse, Joel and Sheila insist that caring for other people is what keeps us human. Even when we're zombies.
While the diet as a whole may not be as varied as your regular diet, it does include enough rich and nutritious foods that it should meet your body's basic needs. The diet only lasts three days, which means you'll soon be able to eat a greater variety of foods that will fill in the gaps you've missed while dieting. If you were to keep following the diet, repeating the 3-day cycle over and over, you'd run into serious nutritional deficiencies.
Get the idea? You need to include lots of fruit and vegetables in your diet. This really helps you feel full, without packing in the calories. As you can see in these two options, you can still add a few extra snacks or calories if you still feel hungry at meal or snack-time. You can always check your food's calories by using one of the various calorie calculators available online such as the one offered by WebMD. Also notice that the only included drink is coffee. Avoid sugary drinks, alcohol and soda, as these will add a lot of calories. Instead, drink plenty of water or herbal tea. If you find plain water too boring to drink- you can add a bit of lemon or try one of the many cucumber water recipes available in this post.
Hi Michele – it can be overwhelming at first, especially when all of the food arrives for the first time! Have you downloaded the South Beach Diet app yet? That has been the best way for me to keep track of menu planning and staying on track, so I would definitely get that if you haven't yet. You can find more info about it here: https://tracker.southbeachdiet.com – there is also a tab for their "PALM" site that can help keep things sorted too. Hope that helps!
None of this feels like a lesson, just like when Joel has to question his gender assumptions. First he assumes a police officer he hasn't met is male; then he vindictively refers to a bunch of clams as bitches (long story). He's quick to say that he admires sensitivity but they really don't have time for this – and that's true, but doesn't stop him from trying to speak inclusively about the clams from then on (just watch the show and it'll make sense!).
An important emphasis of the South Beach Diet is controlling hunger by eating before it strikes. To that end, the South Beach Diet includes three different phases. (3) Phase 1 is one week long and aims to "reset your body" to help burn fat and increase your metabolism, as well as reduce sugar and starch cravings. Phase 2 is for steady weight loss, where you add in good carbs to your diet. Phase 3 is the weight-maintenance phase, where you learn to maintain your new weight without deprivation or hunger, according to the South Beach Diet website.
Data from the Multiethnic Cohort study, which included black, Native Hawaiian, Japanese American, Latino, and white individuals, found that following a DASH-style diet significantly reduced the risk for colorectal cancer. The overall effect was greater in men than in women and was less strong among blacks compared with the other racial/ethnic groups.5
Sugar and processed carbohydrates should be limited, says Massey. That includes soda, candy, and other packaged or processed snacks, such as corn chips, potato chips, and the like. And while artificial sweeteners like those found in diet sodas won't necessarily spike your blood sugar in the same way as sugar, they could still have an effect on your blood sugar and even alter your body's insulin response, though more research is needed to confirm this.
Abby and Joel find another person from the Japopo's receipts who ordered the clam dish. Joel goes to stake out Colonel Ed Thune's house while Sheila attends a work meeting. To be consistent with a previous lie, Joel agrees to give Anne dance lessons. Abby tells Eric she has a date with Sven. Sheila's eye pops out at the meeting with Carl due to the frustration of not killing him. Joel goes to Ed's house undercover to confirm that Japopo's clams are the cause of the undead epidemic. Eric helps Sheila with her eye. Abby goes on a date with Sven but they don't connect. Joel questions Ed and searches his things. Sheila and Carl attend a meeting with an investor, who hates Carl's idea, prompting Sheila to offer her own. Carl berates Sheila, who accidentally bites off her own finger. The skin of Ed's hand slides off during a handshake, proving that he is undead. Joel kills Ed, who had already gone feral, as well as his ball creature. Abby tells Eric about her extreme plan to stop local fracking. Joel comes home to find Anne, but gets her to leave. Sheila shows Joel her mangled finger.
Categories: 2017 American television series debuts2010s American horror television series2010s American sitcoms2010s American black comedy television seriesEnglish-language television programsHorror comedy television seriesMurder in televisionNetflix original programmingSanta Clarita, CaliforniaTelevision series about familiesTelevision series about suburbiaTelevision series created by Victor FrescoTelevision shows set in Los Angeles County, CaliforniaZombies in television
Fresco came up with the premise from wanting to make "a family show with an interesting approach that we haven't seen before". The zombie angle also allowed Fresco to explore the concept of Narcissism stating that "the undead are the ultimate narcissists. They want what they want when they want it and will do anything to just have what they want and don't care about other people's needs" [13]
The Military 3-Day Diet plan is one of the most regimented diets that I've ever reviewed for Cooking Light. It's free to sign up, and participants can download the plan directly from militarydiet.com. The plan is a weekly cycle that includes a three-day meal plan, followed by 4 days off. You can repeat this cycle as many times as you need until your weight loss goal is met.
It seems beyond silly that phase one essentially equates eating a banana with eating a brownie, forbidding both even though they are clearly not the same whatsoever. But at the same time, you are allowed to have artificial sweeteners. And I did begin to crave the sugar-free chocolate syrup and the sugar substitute that I had in my so-necessary endless cups of coffee—and I still do today.
She's right. Before South Beach, my go-to afternoon snack was a pear or a banana. A medium pear contains around 100 calories, according to the USDA, and a medium banana has about the same. Since those were off-limits, my new snack became a low-fat cheese stick, which contains about 50 calories, and fourteen almonds, which come to about 85, per the USDA.
Here's the hard truth—the Military Diet is the quintessential definition of a "fad diet," and it's an eating plan that I would not recommend or advise anyone to follow. Not only does it provide inadequate nutrients, but the diet's food choices and food group servings do not follow the guidelines that research suggests to maintain health and prevent disease.
The South Beach Diet aims to be a lifelong eating plan that you adapt when you reach the maintenance period, which is phase 3. By this point, you have learned how to eat in a healthy way, meaning you can have occasional treats, like a slice of cake, but by using what you learned in phases 1 and 2, you keep yourself from veering too far off the plan.
Adherence to the DASH-style pattern may also help prevent the development of diabetes, as analyzed in a recent meta-analysis, and kidney disease as found in the Atherosclerosis Risk in Communities (ARIC) cohort that followed more than 3700 people who developed kidney disease. [8, 9] Dietary components of DASH that were protective in the ARIC cohort included a high intake of nuts, legumes, and low-fat dairy products. A high intake of red meat and processed meats increased kidney disease risk.
The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication or have a medical condition.
In 2008, Agatston published The South Beach Diet Supercharged, written with Joseph Signorile, a professor of exercise physiology; it included an interval training program.[21] A review for the Academy of Nutrition and Dietetics found that "Readers are likely to see success using this diet and fitness book. I recommend skipping the restrictive Phase One meal plans and instead follow the more balanced Phase Two diet. The simple 20-minute-a-day exercise program is a realistic and inexpensive approach to fitness."[21]
For people living with diabetes who want to learn more about how to make healthy food choices that fit their lifestyle and taste, it can be tough to make out fact from fiction with so much conflicting information in the media. The American Diabetes Association reviews the latest research looking at what is safe and works well for people at risk or living with diabetes. Studies show there are many different eating patterns that can be helpful in managing diabetes. In the long run, the eating pattern that you can follow and sustain that meets your own diabetes goals will be the best option for you.
From the whole wheat toast, you'll get plenty of carbohydrates, fiber, iron, Vitamin B-6, magnesium and calcium. You're probably familiar with most of these vitamins and minerals. Calcium of course is important for healthy bones and teeth. Magnesium is also found in the bones; but is needed too for creating protein. Iron plays an important role in blood, specifically, it carries oxygen in the body (2). That's why iron deficiencies can cause you to feel tired, as oxygen may move more slowly throughout your body. The peanut butter will fill you up with 8 grams of protein and healthy fats. Finally, both coffee and tea are full of antioxidants and caffeine to give you a kick start in energy. As a result, you can confidently choose either coffee or tea. If you want to obtain additional health benefits, try drinking green tea.
While the DASH diet includes solid nutrition recommendations, it can be hard for someone new to these recommendations to make food palatable. We are used to sugar and salt as the major "flavors" of our meals. To make the healthy foods in the DASH diet more appealing, be generous with herbs and spices. There are a number of salt-free spice blends that can be used for many recipes. Some options include
Pared down from the original two weeks to just seven days—a change made in 2017—Phase 1 is meant to jump-start your weight loss. The idea is to "transform your metabolism" with meals that are high in lean protein and low in carbs. At the same time, you begin to lose your cravings for sugar and refined starches—the same kinds of foods that may have piled on the pounds in the first place.
Adopting the general sheen of a family comedy lets Santa Clarita deliver lines about bile and dismemberment the way other TV families talk about household chores (when Joel misremembers Sheila's favorite appendage to eat, she gives him a classic "Do you even listen to me?"). The dissonance and irony beget comedy gold – the best laughs are always unexpected.
The Dietary Approaches to Stop Hypertension, or DASH, diet has been consistently ranked by US News & World Report as a top diet for heart health and weight loss, and it's no surprise why. Unlike fad diets that call for extreme calorie or food-group restrictions without scientific evidence that supports their efficacy, the DASH diet involves making manageable dietary changes that are flexible and rooted in proven nutritional advice.
Hi Ruthann – for the most part you'll just need to buy vegetables to eat alongside your South Beach meals. When first starting the program they recommend 5 servings of "non-starchy" vegetables per day. Here's a good guide to follow for getting started, including the types of veggies you will want to buy: https://palm.southbeachdiet.com/south-beach-living/what-do-i-eat-week-1/. You will also want to download their app, as that also really helps with meal planning. Best – NS
As for packaging, frozen veggies without sauce are just as nutritious as fresh, and even low-sodium canned veggies can be a good choice if you're in a pinch. Just be sure to watch your sodium intake to avoid high blood pressure, and consider draining and rinsing salted canned veggies before eating, per the ADA. If possible, opt for low-sodium or sodium-free canned veggies if going that route.
When Anne puts it all together, she tracks Joel and Sheila to the desert where they're attempting to eulogize Gary and send him off to the great real estate development in the sky. He has decided he wants to die, so they're trying to honor his wishes, but when it comes right down to it, they can't shoot him because he's their friend. And this marks the third time in the episode I cried.
^ Jump up to: a b c Emadian A, Andrews RC, England CY, Wallace V, Thompson JL (November 2015). "The effect of macronutrients on glycaemic control: a systematic review of dietary randomised controlled trials in overweight and obese adults with type 2 diabetes in which there was no difference in weight loss between treatment groups". The British Journal of Nutrition. 114 (10): 1656–66. doi:10.1017/S0007114515003475. PMC 4657029. PMID 26411958.
A 30-year-old Caucasian male without significant past medical history presented with a two day history of nausea, vomiting and diffuse abdominal pain. The patient denied use of any medications (prescription or nonprescription) or any illicit substances. He did admit to occasional ethanol ingestion stating that he consumed four alcoholic beverages (approximately 0.6 ounces ethanol each) the night prior to the onset of symptoms. The patient had a family history of diabetes mellitus type 2 on both the paternal and maternal side.
Heller says offering practical advice can make following the DASH plan easier and longer lasting. The DASH dietary pattern isn't for the short term, she says; it's for life. "If a plan can't be sustained," she says, "why go to the trouble of trying to follow it in the first place?" She offers the following suggestions to help clients and patients follow the DASH diet:
Thank you for taking such a responsible viewpoint in this article. I think so many people and websites nowadays are talking about these diets, like the military diet, as a great way to drop weight quickly, but without discussion the repercussions or downsides to them. I don't think a diet like this is healthy at all, and while it may be handy if you desperately need to drop a few pounds in a few days, I just don't think it's a healthy thing to do at all. I think it's far better to maintain a healthy lifestyle and healthy diet 24/7/365 instead.
But some pleasant news: When consumed in moderation and made with whole ingredients and without added sugar, fruit smoothies can be a good food for diabetes. Consider stocking your fridge with unsweetened frozen fruit so you can whip up one in a hurry for breakfast. Adding ingredients with protein, such as yogurt or a small amount of nut butter, will also help your body break down the carbohydrates more slowly, leading to less of a spike in blood sugar.
Because physical activity lowers your blood glucose, you should protect yourself against low blood glucose levels, also called hypoglycemia. You are most likely to have hypoglycemia if you take insulin or certain other diabetes medicines, such as a sulfonylurea. Hypoglycemia also can occur after a long intense workout or if you have skipped a meal before being active. Hypoglycemia can happen during or up to 24 hours after physical activity.
While there is no strict calorie counting with this healthy-eating plan, its restriction of many common foods in the American diet may make it more difficult for some people to follow, particularly over the long term, than other online diet plans. Fortunately, the South Beach Diet website offers beneficial tools to help you stay on track. You can log your daily meals and snacks to keep a close eye on your nutrition intake.
While the South Beach Diet focuses on healthy eating overall, some phases are pretty extreme, and its total elimination of refined carbs and white sugar makes it difficult for some people to follow. You may need to muster up major willpower to stick to the program and see significant long-term results. That said, the South Beach Diet provides the essential online tools – including tracking features and an active member community – to provide the encouragement and support you need to succeed.
The DASH diet and the control diet at the lower salt levels were both successful in lowering blood pressure, but the largest reductions in blood pressure were obtained by eating a combination of these two (i.e., a lower-salt version of the DASH diet). The effect of this combination at a sodium level of 1,500 mg/day was an average blood pressure reduction of 8.9/4.5 mm Hg (systolic/diastolic). The hypertensive subjects experienced an average reduction of 11.5/5.7 mm Hg.[10] The DASH-sodium results indicate that low sodium levels correlated with the largest reductions in blood pressure for participants at both pre-hypertensive and hypertensive levels, with the hypertensive participants showing the greatest reductions in blood pressure overall.
Then what is even more amazing is the resolution with Anne, which I should have seen coming but totally did not. Sheila tells Anne the truth and that, coupled with the fact that Anne's bullets have no effect on Sheila and seeing Gary's talking severed head, cause Anne to decide Sheila has "risen from the dead" and is doing God's work by "ridding the world of evil-doers." Which, I mean, is basically what the Hammonds are actually doing. It's just a little awkward and weird that Anne treats Sheila like the second coming of Jesus.
The Hammonds—husband Joel (Timothy Olyphant), wife Sheila (Drew Barrymore), and daughter Abby (Liv Hewson)—are a typical middle-class family living in suburban Santa Clarita, with Joel and Sheila working as real-estate agents for the same firm. While showing a house to potential buyers, Sheila throws up a great deal of vomit and a strange red ball of flesh. This causes them to lose the house's listing to their co-worker, the sleazy Gary West (Nathan Fillion). After vomiting, however, Sheila begins to show changes to her personality, becoming bolder and more impulsive. She exhibits physical changes as well, such as the lack of a heartbeat, thickening blood, and a strong craving for raw meat. Their neighbor's son Eric (Skyler Gisondo) suggests that Sheila may have become a zombie, a fact the family soon confirms. The Hammonds now face the challenge of having to keep Sheila fed on human flesh without alerting the authorities, especially their cop neighbors.


pampas2palms: Its too darn hot!
It's hot here in Palm Springs - VERY HOT! with temperatures exceeding 110F (that's 43C for my UK friends) on a daily basis, it's just too hot to be outside after an early breakfast. Garden work is restricted to a few quick jobs in early morning. Sadly there's not much of interest to report about my yard. On one occasion a couple of weeks ago, the temperature reached 121F (49C), almost touching the all-time record. The result has been a rather devastating amount of scorch and some losses. I don't recall so much damage last summer and not surprisingly, days over 110F already exceed last year's records. So if I were to write about my garden, it would be a sorry tale of woe and some rather miserable pictures of incinerated plants. Instead a little floral color of my own making!
Having to escape indoors for much of the day, I have been trying to paint on a daily basis. And as I haven't inflicted my painting on you recently, here are some of the newer ones. Inevitably there are lots of flowers!
However I've been trying to be adventurous and to paint different subjects and in a looser style. There have been quite a few hitting the failure pile - these are some of the better ones! Its been fun and challenging.
Beautiful pieces you have done there, and especially liking the stronger colour of this batch of paintings. Stay cool, and thank goodness for air conditioning!


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Good balance between star collection and the prices of items in the shop.
Control over your pandas is a little too left to chance.
One of the more unique 'how far can you travel' high score games to hit the app store, wrapped in solid presentation and a great balance between shop prices and currency collection.
Sometimes you feel ridiculous repeating the premises of some iPhone titles, but at least a lot of them seem to make sense, at least in their own strange universe. With Electric Tentacle, even its universe is an oddity. Animals shrunk to microscopic size, using electricity to travel through the highways and bi-ways of where ever you've been stuck, trying to escape the evil nanomachines. Keep in mind that this is a high score game based around seeing how far you can get before you head to the in-game shop to purchase upgrades with all the stars you've collected, only to try all over again.
Now the control scheme is a unique one, but remember that unique doesn't always mean good. Your pandas travel by electric current which is activated by touching the screen. The panda will then move towards that direction, and the further it has to travel, the more it will accelerate. Things get even hairier when you pick up another panda for the ride (and if two wasn't psychotic enough, try three)! Then the electric current travels in-between the pandas as well, and if you're not careful you'll lose one careening off the left or right of the screen. It's kind of like when you get multi-ball in a game of pinball and then immediately lose track of all your extra help. The trick to controlling your panda is a slow and subtle approach, of course to continue the pinball metaphor, once your pathways get tighter and tighter as the game goes on, you'll be bouncing off the ceiling and floor, and right into an enemy if not careful.
Throughout the experience, you'll be collecting stars that are used to upgrade your abilities and power-ups in the shop, but luckily you'll never be at want for currency through a nice balance of mission rewards, bonuses, and pricing.
With vibrant colors and a single if not fairly infectious backing track, Electric Tentacle is a lot of fun. The controls can be annoying but it's more due to the random nature of the levels, and the overwhelming feeling you get when more than one panda is introduced than any real problem with the design. Those looking for a new ad break game to pass the time would do well to give this a try.
You and your animal friends have been shrunk down to nano-size by the invaders and now you have to escape!
Tap the screen to zap a bolt of electricity which will drag your creatures toward it. Navigate through tricky obstacles and be careful to not get munched by the nasty enemies!
Electric Tentacle is a unique high score game, as you try and escape be sure to pick up your buddies...the more the merrier as you try collect stars and stay in one piece!
With that 'one more go' level of addictiveness, Electric Tentacle will keep you entertained for hours as you try beat that high score and win your crown!
* Fixed a bug that meant some people kept being asked to review the app even when they pressed 'no'. Sorry about that.
* Fixed a crash and some other small bugs.