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Home NATIONAL Sen.Abaribe Makes Demands As Nigeria Security Forces Crackdown on Separatist Group
Sen.Abaribe Makes Demands As Nigeria Security Forces Crackdown on Separatist Group
The Senate Minority Leader, Enyinnaya Abaribe, on Tuesday, condemned the alleged killings of Igbo youths in Emene, Enugu State, last Sunday, by some security operatives.
He said the killings of the Igbo have given room to wide suspicion of a sinister motive.
He also warned that the labelling of every Igbo group as terrorists and the incessant killings of their youths by the security operatives has become one too many and is no longer acceptable to his people.
Abaribe stated this in a statement issued in Abuja by his Media Adviser, Uchenna Awom, titled 'Abaribe condemns Igbo youths' killings in Enugu'.
He demanded the setting up of a judicial panel of Inquiry by the Governor of Enugu State, Ifeanyi Ugwuanyi.
The judicial panel, according to Abaribe, would help to unravel the truth in the assertions of both the security and other groups on what really happened.
The senator noted that it was "disheartening that security operatives seem to derive pleasure at any slight whim to unleash mayhem, using the most lethal weapons against unarmed Igbo youths at every turn."
"Such unsavoury, brutal and hateful resort to extreme repression, demean Nigeria's democratic ethos and even question her unity," he said.
Part of the statement read, "We are in a democracy where every agency of government, particularly the security apparatchik must adhere strictly to rules of engagement with regards to dealings with the civil populace in such a manner that will be in conformity with international best practices.
"The last time I checked, Nigerians still enjoy the freedom to associate freely. Nobody has told us that the Igbo youths meeting last Sunday was a gathering meant to launch an attack on anybody.
"Who will they attack and for what? What informed the police and DSS deployment to the venue of the meeting?
"Incontrovertible reports suggest very strongly that the killings were ignited when the security operatives stormed the venue of that peaceful meeting, not that the youths marched to anywhere to attack anybody.
"These are the issues that should be addressed at the panel," Abaribe said.
The Minority Leader further said it was most worrisome that the people would no longer gather peacefully in their own country without being dispersed forcefully or be branded terrorists for no just cause.
The lawmaker said he would not want to believe that the wide card labeling of every Igbo youth group as terrorists is a cover to achieve a predetermined plot.
He said, "Let it not be that we now have an army of occupation in South East, working clandestinely to create fears and state of anomie in a region that has remained perhaps the most peaceful in the country."
He, however, advised the youths to remain calm and not to resort to any form of reprisals, or succumb to provocations that could tempt them to take laws into their own hands.
"We await the official reaction of the Enugu State governor on the matter," he concluded.
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As part of the Better Local Care vanguard project to support professionals working to provide specialist care closer to home, Southern Health NHS Foundation Trust, South Central Ambulance Service (SCAS) and care home staff are working together to look at the reasons why care homes make calls to emergency services and finding ways to reduce these. Staff from Southern Health's multidisciplinary care home team, together with a SCAS paramedic identified the top 20 care homes in Fareham, Gosport and south east Hampshire who were high users of 999 but the patients were not being admitted. By focusing on these care homes, they were able to identify areas where they could make a difference.
Keeping residents as well as possible by ensuring any ailments or conditions are dealt with minimal delay prevents them from developing more complex health care needs which may require admission to hospital. Care home staff received training on fall prevention, seating positions, pressure ulcers, urinary infections, hydration and nutrition and advised how to recognise earlier signs of these issues which would have an effect on health.
The Multidisciplinary care home team, which includes registered mental health nurse, senior occupational therapist, community matron and healthcare workers, worked with the homes to assess and treat residents without the need for a GP referral, ensuring those who need the service received it when they needed it most, often preventing conditions getting worse and needing further treatment.
The pilot also highlighted the benefits of care homes by contacting a duty GP via the direct line to a GP, by-passing reception, which staff could call with any urgent concerns about a particular resident.
They have also worked closely with SCAS to make end of life care plans robust enough to be acted upon by all healthcare workers, including instructions for Do Not Resuscitate and to ensure the wishes of the patient are adhered to.
The pilot has resulted in a significant reduction in both the number of calls to 999 (by some 39.1%) and the number of residents admitted to hospital of some 22.3%. At one particular care home between July and September, 18 calls were made, of which 10 resulted in admission to A&E; October and December the same care home made only 5 calls of which 3 were admitted to A&E; showing both a reduction in callouts, but also that those calls which were made, were more likely to require admission which meant the callout was the right decision to make on those occasions.
Janine Harriman, Community Matron for SHFT care homes team explains that "by working more closely with care homes we have been able to better understand the issues and work with them to rectify, providing training, support and therapy in a more joined up, timely manner. It has had a very positive impact not only on the residents who we provide care for but also to the staff who support those residents".
Brook Lane Rest Home is involved in this pilot and is delighted with the impact it has had not only on the residents, but also on staff. Like many other homes, they previously relied on calling 999 for emergency help with residents and GP referrals to therapy services meant residents had to wait a few weeks before treatment, when often they needed that care sooner. Both issues have been addressed via training for staff and direct access to the occupational therapist, without the need for a GP referral.
Plans to evaluate the pilot are currently underway with the prospect of rolling this model out across more care homes in the area.
This pilot is part of the Better Local Care vanguard project to support professionals working to provide specialist care closer to home.


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Q: Speed of gravitational waves vs speed of light I own an educational YouTube channel on physics and astronomy. I am currently working on a gravitational waves video extension to my "How Fast Is It" video book on relativity theory. I have a question on the speed of gravitational waves. I understand that the field equations show that it is equal to the speed of light. My question goes one level deeper. My audience knows that the speed of light is fixed by two key characteristics of 'empty space' namely permittivity and permeability. The speed of a gravitational wave would be related to the elasticity of 'empty space'.  Is it just a coincidence that these give the same result, or is there a deeper physics in play here?

A: A better way to think of it is "speed of causality". That's the fastest any cause-and-effect will spread over space.
With nothing to cause it to go slower, changes to electric and magnetic fields will occur at that speed. No coincidence that changes to spacetime (causing gravity) propigate at the same speed.
You really need to show how Minkowski spacetime results in such a speed limit as a basic principle. It's not a speed limit in the usual sense; it's a deep principle of what speed is.

A: Nonsense. Maxwell derived his electromagnetic equations, with $\epsilon_0$ and $\mu_0$, and those quantities were known. The fact that his equations led to the speed of electromagnetic waves to be, in terms of $\epsilon_0$ and $\mu_0$, equal to the approximately then known speed of light is a big part of what led Maxwell to conclude that light is electromagnetic.
No coincidence, light is electromagnetic and those entities define the speed of propagation of electromagnetic waves.
See Jackson or any other good electromagnetism textbook for the derivations.
Btw, it's not about units. $\mathbf{E}$ and $\mathbf{B}$ are simply used to define forces, and the values of those were known, so $\epsilon_0$ and $\mu_0$ were also approximately known.
Finally, it's gravitational wave speed also because Einstein got GR (general relativity) through a (mind blowing) generalization of special relativity to an arbitrary frame of reference, with gravitation equivalent to acceleration (equivalence principle). SR (special relativity) included $c$, the speed of light, as the maximum speed possible, achieved by zero mass particles. GR had to reduce to SR in a local inertial frame, so it also had to include the same $c$. GR waves reduce to a Lorentzian wave equation with $c$, in the weak field limit. Also in a local inertial frame.
Theoretically it all adds up, there's isn't any other way if GR is true. The way it might not be totally true, with respect to gravitational waves going at a speed different (and necessarily slower than ) $c$ is if the graviton (the presumed quanta carrying the gravitational radiation or force) is a non-zero mass particle. Based on measurements of gravitational effects in the solar system it is known the mass of the presumed graviton is zero to about 1 part in (and here I am not sure I have the correct number, but it is to great accuracy) maybe about $10^{15}$ or $10^{18}$. The eLISA satellites to be launched in a few (2-3?, see Wikipedia on it) years will measure it even better by seeing if there is any delays between different frequencies of the gravitational waves they will see - it'll have orders of magnitude more accuracy, it's interferometer baselegs are 1 million Kms compared to the 5 Kms of LiGO which recently detected gravitational waves.

A: Not really. The "speed of light" has very little to do with light; it is built into the actual geometry of spacetime independent of what matter fills it.
In particular, $\epsilon_0$ and $\mu_0$ don't tell us anything physical about the vacuum; looking at the (simplified) expressions
$$E = \frac{1}{4\pi \epsilon_0} \frac{q}{r^2}, \quad B = \frac{\mu_0}{4\pi} \frac{I \times \hat{r}}{r^2}$$
we see that $\epsilon_0$ and $\mu_0$ just define the units of the electric and magnetic fields. We can (and often do) change their definitions; for example, in Gaussian units, we set $1/4\pi \epsilon_0 \to 1$.

An edit to address the comment: light and gravitational waves travel at the "speed of light" because they obey the relativistic wave equation,
$$\partial^2 \phi = (\partial_t^2 - \partial_x^2) \phi = 0.$$
You can't write this second-order differential equation in terms of two first-order differential equations in a natural way; you have to make an arbitrary choice. For example, let's consider the simpler case of the harmonic oscillator, $\partial_t^2 x = -\omega^2 x$. We can rewrite this equation as
$$y = \alpha \partial_t x, \quad x = -\frac{\omega^2}{\alpha} \partial_t y$$
by introducing the intermediate quantity $y$. Then you could say $\alpha$ is the "resistance to motion" while $\omega^2/\alpha$ is the "restoring force". But these quantities are totally meaningless because $\alpha$ is arbitrary. Splitting the electromagnetic field into electric and magnetic fields and introducing the constants $\epsilon_0$ and $\mu_0$ is exactly the same.

A: Existing answers correctly bring in the fact that the speed commonly indicated by the symbol $c$ is primarily about geometry of spacetime and the notion of causality, or what is the difference between temporal and spatial separation. Only secondarily does it have anything to do with electromagnetic phenomena. But nevertheless, electromagnetic influences do propagate at $c$ in vacuum (relative to anything nearby), so one might ask whether this is a coincidence, before even coming to the issue of gravitational waves. In other words we have three speeds to consider:

*

*$c_{\rm s}$ the speed appearing in the formula for invariant spacetime interval:
$$
ds^2 = -c_{\rm s}^2 dt^2 + dx^2 + dy^2 + dz^2
$$

*$c_{\rm L}$ the speed appearing in Maxwell's equations:
$$
c_{\rm L}^2 \nabla \times {\bf B} = \epsilon_0^{-1} {\bf j} + \frac{\partial {\bf E}}{\partial t}
$$

*$c_{\rm gw}$ the speed appearing in the Einstein field equation of general relativity, which, in the weak field limit and Lorenz gauge, can be written
$$
\left(-\frac{1}{c_{\rm gw}^2}\frac{\partial^2}{\partial t^2} + \nabla^2\right) \bar{h}_{ab}
=  -\kappa\left( T_{ab} + t_{ab} \right)
$$
where $\kappa$ is a constant proportional to $G$.

So now the question is, is it a coincidence that $c_{\rm s} = c_{\rm L} = c_{\rm gw}$,
and what does this tell us about the properties of spacetime?
First, it is no coincidence that $c_{\rm s} = c_{\rm gw}$. These are precisely the
same quantity, the same aspect of the geometry of spacetime.
Next, to explain why it is that $c_{\rm L} = c_{\rm s}$ one cannot really do much better than saying that this is the way the equations come out. But one can add a little. In any field theory we have learned to expect that the equations do not bring in unnecessary baggage, and Maxwell's equations are about as simple as they could possibly be while respecting the principle of relativity and the kind of spacetime geometry we have (i.e. one with a finite $c_{\rm s}$). If they brought in some other speed then they would have to become quite a lot more complicated, and there would have to be a new physical quantity associated with the fields---something like mass, for example.
An observation which is relevant to some astronomical observations is that since the region between stars and galaxies is not a perfect vacuum (it has a few hydrogen atoms and other stuff floating around), it has a refractive index very very slightly different from 1, so light propagates across the universe at a speed very very slightly different from $c_{\rm s}$. Gravitational waves, on the other hand, interact with this very diffuse gas much less, so their speed is in practice closer still to $c_{\rm s}$ (if someone would care to place a number on this so as to improve this answer, please do).
Finally, what does this tell us about spacetime. I guess one thing one might like to note is that it is hard in practice to do stuff that introduces significant amounts of curvature into spacetime: very large masses and motions are required to generate gravitational waves of significant strain amplitude. In this sense spacetime is sometimes said to be very "stiff".

A: Let us begin with an article: https://doi.org/10.1007/s11467-019-0913-4
This is one among the articles which refer to a time delay of 1.7 seconds in observing a gamma ray burst following an observation for gravitational waves.   That is, gravitational waves were observed first and then light rays (gamma-ray-burst) were observed after 1.7 seconds from a collision of two neutron stars which are about some billion light years distance from our earth.  Even if we begin with the assumption that incidents for both observations happened simultaneously at stars, then we find that speed of gravitational waves should be greater than the speed of light rays of gamma-ray-burst.  Since no energy wave in "vacuum" can exceed speed of light in "vacuum", then we can conclude that the gravitational waves were released first and the light waves were released second.  Elementary numerical calculations also show that the difference 1.7 seconds in reaching earth from a billion light years distance place does not make any significant difference between speed of gravitational waves and speed of light rays.  So, the speed of gravitational waves should be equal to the speed of light rays, and the event of occurrence for gravitational waves happened first and the event of occurrence of light rays happened second (at the place of stars).  So, no deep physics and no deep mathematics are involved in the conclusion that the speed of gravitational waves is equal to the speed of light rays in vacuum.  I like to add some more things without giving a reference for basic principles (to avoid "self-promotion").

*

*When two self rotating neutron stars come closer the magnetic fields of the stars are disturbed and energy waves are released from the magnetic fields.  These waves are gravitational waves.  Since they are from magnetic fields, they are of electromagnetic wave type.  So, speed of gravitational waves is equal to the speed of electromagnetic waves in vacuum.

*After 1.7 seconds collision happens.  During this collision, gamma rays, X-rays, ultra-violet rays, visible light rays and infra red rays may be released.

These two things are also acceptable reasons for calculating the speed of gravitational waves and for the delay 1.7 seconds.  These reasons mentioned above are consequences of a fundamental question: Why should we accept the earlier "standard" reasons for creation of gravitational waves?

redpajama_set_name: RedPajamaStackExchange


Carbon County Stations 7, 1 and 2 were dispatched at 12:22 for an apartment building fire at 226 Delaware Avenue.
Indian River County (FL) Sheriff's Office deputies rescue woman from burning wreckage of a collision between a septic truck and car on March 23, 2016.
On March 8th, 2016, Stockton Firefighters responded to reports of a structure fire in the area of Roosevelt and Pilgrim. Fire crews arrived on scene to find fire in a boarded-up residence, in a structure that had recently previously burned.
Best of the Rest: Firefighter Saves His Son, Station Duties, Wearing "The Purse", and more!
Here are some articles to keep you up-to-date on what is going on in the fire service. Best of the Rest: Firefighter Saves His Son, Station Duties, Wearing "The Purse", and more!
A family of three and their dog escaped safely Tuesday night after their 126-year-old house in Upper Augusta Township was gutted by a raging fire. Helmet Cam Video of the fire.
17 Years… Make it Matter!
There have been highs and lows to my career. Probably not much out of the ordinary for many firefighters...and yet I wouldn't change a thing. The last 17 years... the experiences, the calls, the firehouse life, and the people who I have served with is what makes up 1/3 of my life. It is my history that I hold near and dear to my heart.


POMERO SUPPLY CHAIN MANAGEMENT IN PRACHINBURI.
Supply chain managementis a concept thatusesdepartment, information, technologyactivitiesand resourcestogetherfor themaximum potential and reducethe total costof producinga minimumof organizationsto managethe whole system, from upstream to downstream. This will increase efficiency throughout the manufacturing process to the consumer to create a sustainable competitive advantage.
The currentproblemsare severedroughtincreases.EspeciallyPrachinburiAffectthe cultivation offruits, especially grapefruit. Make damage grapefruit. Output is not as expected. There was no shortage of grapefruit in both domestic and foreign.In addition, thearea to growgrapefruithas decreasedsteadily asthe floodsof the past. As a result, grapefruit is not enough demand in the market.Because of this, the farmers have no concept of the integration of the agency to produce grapefruit is very efficient and quality to customer expectations.
วชิราคม, ธนพัฒน์. การจัดการโซ่อุปทานส้มโอ จังหวัดปราจีนบุรี. Journal of Logistics and Supply Chain Management Ramhkamhaeng, [S.l.], v. 3, n. 1, oct. 2016. ISSN 2351-0722. Available at: <http://ojs.ru.ac.th/index.php/Logistic/article/view/53>. Date accessed: 20 apr. 2019.


Resume Summaries: In or Out?
A resume summary is a short statement that typically goes at the top of the resume to pinpoint your skills and highlight parts of the rest of your resume. Resume summaries typically describe who you are as a professional, what skills you possess, and where you would like to go with your skills. A resume summary can be called many different names, but profiles, resume statements, career statements, personal profile statements, and a summary of qualifications are all different names for the same thing. A resume summary should essentially illuminate how your skills and experience fit together to work well with the organization for which you're applying. It should also seek to make your resume stand out among other applicants.
Some career experts say that resume summaries are a must, while others say they are outdated and can be a detriment to the prospective employee when poorly written. Since not all career experts agree on whether or not you should create a resume summary, it's likely that not all employers have the same preferences on resume summaries either.
In the past, most people had objective statements on their resumes rather than summaries, but it's important to note that they are not the same thing. An objective statement's purpose is to describe to the potential employer what the applicant's desired position is and what their personal goals are for attaining a job. This has become an outdated practice because these days, employers know what job you're applying for, and therefore, the objective just takes up space on your resume. If you're going to have a header section that orients the employer to your resume, make sure you write a version of a resume summary that tells the employer what you bring to the table rather than telling the employer what you want. This is why most career experts say if you're going to have some sort of profile, make it a gripping summary rather than an objective statement.
Some experts say that a summary helps center the rest of your resume. Since resumes are often just nicely formatted lists of your accomplishments, creating a resume summary helps orient the reader toward the skills and experiences that are well suited for the position you're applying for and gives them the key takeaways you want them to have.
The standard size of a resume is one page, and some people argue that having a resume summary just takes up precious space and limits the accomplishments you can list to really prove your qualifications.
The whole goal of your resume is to grab the attention of the prospective employer, and while your accomplishments may not automatically jump out among the rest of the stack, having a catchy, action-oriented summary can do just that. It also can help show that you know how to articulate yourself and write well.
If you have to submit a cover letter with your application, then chances are whatever goes in your resume summary has already been conveyed in the cover letter. When in doubt, leave the summary out if you're already required to submit a cover letter.
Some employers spend less than 10 seconds reading a resume, and if they do that, they are likely to read the first few things on the resume and move on. For some, this means that resumes with resume summaries that effectively advertise the applicants are the ones who make the cut and the ones who don't get thrown out. This can also help if you have spotty experiences, because it can make you stand out among candidates with better credentials but poor self-promotion on their resume.
Because many people in the past have used resume summaries to make themselves stand out when they aren't necessarily qualified or have the right experiences for the job, many employers have started to view resume summaries as a way of making yourself look good or filling your resume when you aren't actually qualified. This is especially true for candidates looking for entry-level positions.
So, Should You Put a Summary on Your Resume?
The truth is, whether you add a summary to your resume or not is a matter of personal preference. There are certainly both pros and cons of doing it, but it's impossible to know what the preferences are going to be of each prospective employer. If you're already submitting a cover letter, you should consider leaving the summary off; other than that, it's all about making the choice that seems best for the job you're applying for.
Some career experts suggest that resume summaries are best for professionals with an abundance of experience to really highlight their main career experiences and their self-definition as a professional. If you're looking for an entry-level job or an internship, on the other hand, a resume summary may simply look like you're trying to cover up your lack of experience.
If you decide to include a resume summary, here's a tip: bullet points are in and paragraphs are out. Try to highlight your skills or create a professional persona by adding bullets that describe who you are and what you do, for example, "graduated at the top of the class in political science," or "extensive experience implementing community-based programs for various nonprofits," or "over two years experience volunteering with local women's shelters." Make your summary skim-able and aim to write exactly what you want the prospective employer to take away from your resume about you as a candidate.
Should I Put That On My Resume?


France and Portugal, together with other European countries,are witnessing the emergence of citizen initiatives and forms of collective organization as alternatives to current spatial planning practices. By bringing together senior and young researchers from these two countries around the transition to more sustainable societies,this project explores two analytical lenses: the "alternative" and the "common".
This last concept points to the underlying principle of both the collective activity of individuals in building more sustainable societies and the governance processes that encompass such activity (Dardot and Laval 2014). Articulating innovatively concepts around the social ecological transition both in cities and in peri-‐urban and rural areas, this two-‐year project promotes field trips and workshops in both countries and a final conference to be held in Paris. The project aims to consolidate the theoretical-methodological and interdisciplinary training of students to facilitate future insertion in the scientific labor market.


text:
"Elvis (...I Remember)" is a song by Australian rock band The Screaming Jets. The song was released in June 1997 as the lead single from the band's fourth studio World Gone Crazy (1997). The song peaked at number 71 on the ARIA Charts.

Track listing
 "Elvis (...I Remember)" – 3:54
 "Sense" – 3:21
 "Silence Lost" – 4:20
 "Fortunate Son" – 2:31

Charts

Release history

References

1997 songs
1997 singles
Songs about Elvis Presley
The Screaming Jets songs

redpajama_set_name: RedPajamaWikipedia


text:
Death toll rises after landslide at Myanmar mine
Published: Friday, 24 December 2021 08:18
At least three people have been killed and an estimated 50 remain missing after a landslide at a jade mine in the remote Hpakant area of Kachin state, Myanmar on 22 December.
Many were swept into a lake below by the landslide of mining waste, prompting a desperate search by volunteers and workers aboard rubber boats. The missing are feared dead.
Deadly landslides and other accidents are common in Hpakant, the centre of Myanmar's secretive jade industry. In a landslide last weekend, media reported at least six people were killed. In July 2020, more than 170 people died in one of the worst disasters in Hpakant after mining waste also collapsed into a lake.
Myanmar produces 90% of the world's jade.
Myanmar jade mine accident
Eleven rescued, ten killed in China gold mine collapse...
Mountainside collapse at Chinese mine leaves 10 dead...
Newmont ranked as Top Miner in FORTUNE's 2018 List of World's Most Admired Companies...

redpajama_set_name: RedPajamaCommonCrawl


On November 6th, Ohioans will wake up to one of the strongest economies they've ever experienced.
On November 6th, Ohioans will decide whether to continue on this strong economic path or to reverse course. We already know that Richard Cordray has promised to flip Republican economic policies and that his plans would require raising taxes.
Let's keep Ohio's economic future bright on November 6th by electing Mike DeWine and the entire Republican ticket!
When you head to the polls on Tuesday, don't forget to take your Republican slate card with you! Print it here.


For many years, Master Lin Hsien-tsung searched for a key to unlock the shackles of the mind. He traveled all over the world to find a method or technique that could solve Mankind's problems and release potential. The quest for such a key took teacher Lin to Australia and the United States, where he studied Western science and processes of the mind, but he still could not find an effective way to break through. He also read extensively,from psychology, philosophy science, quantum physics, and mind sciences, to classics of various religious sects and factions.
Finally, he saw a light after studying Buddhism for decades. From concepts of the Consciousness-Only school, he developed the technique that can completely remove deep obstacles in the human mind - "Consciousness-Only Deep Communication". So far, he has completed nearly ten-thousand successful cases, helping others to improve their lives, and revealing the mysteries of human life.


I have setup a opensips 2.3 on a new server and I'm getting ghost calls into my system. How do I stop these ghost call? The opensips server is brand new. the install is clean and nothing has been touched after the initial simple residential script setup. What can I do to defend myself from these ghost calls.
You can set client to use random port instead of standard 5060.
But a better way is to set the client to only allow your required domain, if possible.
iptables, fail2ban and ip authentication if your users have static ips.
+1 for iptables, fail2ban and ip authentication. Configure you log properly and have fail2ban ban IPs failing to authenticate.
User authentication at SIP level as well.
My understanding of ghost calls is that they go directly via the client through a loophole in the IP range rather than through the SIP server itself. In this case, server-based solutions don't seem likely to work?
Do you mean a client is using SIP/RTP to make a call direct to backend servers and bypassing the opensips proxy? Or somehow just using RTP without SIP to bypass the opensips proxy?
In a ghost call, there is no RTP -- only the INVITE. If you answer a ghost call, there will be no response. Usually, an IP scanner named 'SipVicious' directly sends the INVITE to your client, so your server may not come into play at all.
Thank you all for your reply's I will learn how to implement fail2ban integration in a VM environment and then commit it to the production server.
You might need to do a Wireshark trace and find out if the calls originate externally into the system.
If you are in an open DMZ with the router, that could be just the start of your problems.
I then had a couple of dozen automated break in attempts trying to access the system.
You need to pay a lot of attention to the system logs otherwise you may not even notice.
Go over your router very carefully and restrict everything you do not need exposed.
Port 5060 is a very popular target with automated robots, use another port if your able to.
Is there a way to change opensips port ? Whenever I try it doesn't even start.
In addition to iptables/fail2ban you should inspect the useragent that the packets come from, most of them will come from sip vicious or friendly scanner etc, you can block them with iptables and/or with drop() in opensips, this will stop the scanner right away because he won't get any replies so he will just move on.
Is there any documentation I could read to understand the process you just described?
Another approach is sending 200 ok and then exit().
Sending a 200 ok will notify the hacker that a sip server exists on the IP/port, simply ignoring the request is best.
thank you, i added this to my opensips.cfg file and it started successfully. Lets see if it works.


text:
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        <groupId>cn.edu.ruc.iir</groupId>
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                        <phase>package</phase>
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redpajama_set_name: RedPajamaGithub


text:
The Settlers II
Game » consists of 4 releases. Released Jan 25, 1998
Settlers II is a real time strategy game released by Blue Byte Software in 1997. It is the second in a long line of Settler games but is considered by many as the best in the series as the following games moved away from its unique type of gameplay.
Compared to modern games, It moves at a relatively slow pace and its gameplay differs greatly from other Real time strategy games.
One of the main differences between settlers and other Real time strategy games is that units are not directly controlled by the player but instead they automatically complete tasks assigned, such as building structures or gathering resources. These units or 'serfs' can only travel along set roads between structures. There is a serf for each stretch of road and each road is denoted by a flag at each end. Resources are carried between these road networks using a kind of 'serf-chain' system, by which workers carry resources from one flag to another along their stretch of road. Only military Units may move freely across the map. Although these are also not directly controlled by the player but instead can be ordered to attack enemy military structures, a task in which they then carry out automatically.
The player Starts out with only a headquarters and a small area of land on which to build on. This area of building land can be Increased through the construction of military structures such as barracks, guard houses, watchtowers and fortresses. ( Fortresses increasing the area the largest amount while barracks the smallest). Resources are gathered Through the construction of special buildings. Such as the Quarry or Fishery. Once constructed a specialized worker automatically gathers resources from the surrounding area. The main resources are food, rock, lumber and ores which can be used to building more buildings and units or used to create specialized resources such as beer and weaponry to produce soldiers and Coins to increase the soldiers rank.
Soldiers are used to take over enemy structures and reduce their building area. The player can send any amount of available soldiers to an enemy military structures where the soldiers must defeat all enemy soldiers housed in the building ( higher rank soldiers have a higher hit rate and health). If the player's units defeats all housed soldiers then the military structure is taken over by the player and all non-military structures are burned. An enemy faction is destroyed when the player can defeat all soldiers housed inside that enemies headquarters. Once defeated the headquarters disappears and all serfs are left to wonder around the map until they slowly die ( very dramatic). A player wins a game when all enemy factions have been destroyed. Settlers can be played in both a campaign mode or a through a standalone scenario created by the player.
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Valhalla Hills
Lethis - Path of Progress
Majesty 2: Battles of Ardania
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The largest non-profit hospice in Nevada, Nathan Adelson Hospice, has finalized the acquisition of Las Vegas Solari Hospice Care, an end-of-life healthcare organization previously owned by HealthCare Partners Nevada, LLC. The acquisition is the result of a long-standing relationship between HealthCare Partners and Nathan Adelson. Carole Fisher, president and CEO of the hospice indicated a hope to continue exploring strategic relationships and partners that ensure sustainability.
According to a report conducted by Applied Analysis, Nevada's mining industry has posted significant increases in the production of gold and copper over the past 12 months. In fact, the increase has been the fastest recorded in recent history. Additional results of the analysis included information on the economic input of mining. For example, the industry supports over 28,000 jobs in Nevada and the state's 119 active mine operators paid nearly $92 million last year through the state's net proceeds of minerals tax.
Nevada Attorney General Adam Laxalt has launched an "AG for a Day" tour in an effort to take state government directly to the people of Nevada's communities. Laxalt, along with members of his staff, will present on topics including open government, trends in consumer fraud, taxation and local government finance among others. The tour runs until mid-October across the state and began in Fallon last month.
The Cleveland Clinic Lou Ruvo Center for Brain Health has partnered with the University of Nevada, Las Vegas (UNLV) to offer the first Master of Healthcare Interior Design Program in North America. The post-professional program is part of the School of Architecture and provides students with a cross-disciplinary and research-driven education that focuses on the design of healthcare environments for those living with neurodegenerative diseases.


Dense-growing, small evergreen shrub valued for its large trusses of showy flowers. Thrives in cooler regions but some protection from winter wind is helpful. Very effective in foundation plantings or as an accent. Dense foliage makes good foundation planting or hedge. May be planted as a single accent or grouped in islands around the edges of sparsely canopied trees. Ideal for separating driveways or front yards. Plant where it gets enough sun to backlight the flowers, which will make the gorgeous color 'pop'.


Eardrop is a 7 letter word which starts with the letter E and ends with the letter P for which we found 2 definitions.
(n.) A pendant for the ear; an earring; as a pair of eardrops.
(n.) A species of primrose. See Auricula.


Home / random / SELAMAT HARI IBU!
"No status on med soc, no photo upload. but trust me, i love you mom."
same goes to me, but at least, we appreciate our mom in our own ways. no social media, but deep in our heart, she's still the best mom!


Last year Jen Weber of Your Wedding by Jen and I created Cincinnati's first alternative wedding expo, Love+Bash. If you read my blog regularly I am sure you know all about it. :) Because we were so excited to be bringing something so unique to Cincinnati we decided to have a contest to go with it. I love to shoot alternative/offbeat weddings. I asked couples to send me their wedding ideas/love story and I would chose one to shoot for free and Jen would offer them full planning. Tons of other amazing vendors got on board and we ended up with a wedding giveaway worth almost $10,000. I got some really awesome entries, it was tough choosing a winner.
Courteney and Drew's story really stood out to me. It wasn't just the fact that they are planning a carnival themed wedding with rides, a concession stand, and all of the fun games you see at a carnival. This did sound pretty amazing to me, Umm I want to take pictures on a carousel. It was also the love story Courteney sent in with her entry. It was so sincere and heartfelt. She admitted she thought Drew was a tool in the beginning, I loved her honesty. She talked about all of the sweet things he did to win her over and prove her wrong. He encouraged and supported her before he even got a first kiss. She talked about how positive he is and how eventually a friendship blossomed into love. The story was about 5 pages long, but I enjoyed reading every bit of it. Needless to say I found my winners.
I have really enjoyed getting to know Courteney and Drew through their planning process. They are a blast to be around. I cannot wait to work with some of my favorite vendors on their wedding in May! Your Wedding by Jen planning/event design, Marti's Floral Designs on flowers/event design, and the super talented Kristen of Five Dot Design is in charge of all of the paper goods, this will be a wedding to remember for sure!
For Courteney and Drew's engagement session they wanted to do something unique so we headed to the Cincinnati Zoo. We got VIP access to some of the animals thanks to Drew's good friend Travis, who happens to be one of my first clients ever! Small world!!
p.s. For those of you wondering, Love+Bash 2012 is in the works...stay tuned!


text:
Q: Probability the number of coins coming up heads I throw a coin $n$ number of times.

1) What's the probability of the number of times of coming up tails is divisible
  by $4$?
2) What's the probability that it's not divided by number $4$?

My reasoning is to tackle by going one by one.

A: $$\left(\frac12\right)^n \sum \binom n k [0\le k\le n][k\equiv 0\pmod 4]$$


text:
Mary Trump says President 'is not going to get better and he is without question going to get worse'
July 18, 2020 July 18, 2020 4 min read Kelechi Ephraim
President Donald Trump's niece Mary Trump — a psychologist whose recently published book criticizes the President and his family — asserted Friday that her uncle's childhood is affecting his ability to govern in a crisis.
"Donald is a psychologically deeply damaged man, based on his upbringing and the situation with his parents," she told CNN's Chris Cuomo on Friday on "Cuomo Prime Time."
"He is not going to get better and he is without question going to get worse," she added.
The stinging assertion is another blistering comment from one of Trump's family members who has been interviewed often this week after her book, "Too Much and Never Enough: How My Family Created the World's Most Dangerous Man," went on sale. The book paints the President in an unflattering light and traces his governing style back to his childhood.
When asked if the President was known among family members as someone who didn't tell the truth, Mary Trump asserted that he "does on some levels know what he's doing" and pointed to issues such as not wearing a mask. She said her uncle is not anti-science but will ignore facts in order to spin his preferred narrative.
"I think one of the reasons he's sort of unraveling a bit now is because what he's always done in the past, that used to work, isn't really working as effectively anymore, so it has him scrambling a bit," she said.
"Knowing, not knowing; educated, not educated as you say — ultimately it is irrelevant," Mary Trump added. "Just as in the grand schemes of things — although I think it's extremely useful in some ways to understand his psychology — it's irrelevant compared to what he's doing, that's what we need to focus on."
Trump, after days of silence about her, called her "a mess" earlier on Friday and alleged that she wrote "untruthful things."
In a series of tweets Friday, he accused her of breaking an unspecified law and lambasted her for criticizing his parents who, he added, "couldn't stand her!"
Mary Trump, in turn, asserted that she was legally in the right.
"I never had Donald's tax returns in my possession, so I could not have revealed them to anybody," she told Cuomo.
She and her grandmother "were very close," she said. "I really loved (my grandmother) and believe that she loved me. My grandfather, I don't think was really, had real positive feelings towards anybody except perhaps Donald."
She called the assertion that she was a mess "an attack he hurls, predominantly, I think, about women."
"Honestly, I'm in very good company," she added. "I believe he's said the same thing about Nancy Pelosi, and I'm fine with that."
She has faced litigation from Robert Trump, the President's brother, who argued in court that the book violated a confidentiality agreement related to Fred Trump's estate. But a New York judge ultimately allowed its release. It sold a staggering 950,000 copies by the end of its first day on sale, publisher Simon & Schuster said Thursday.
Mary Trump has made damning allegations against the President in recent TV appearances, including claiming she's heard Trump use racial slurs. The White House has denied her claims.
In the series of tweets Friday, Trump also had choice words for John Bolton, calling his former national security adviser a "lowlife dummy." Bolton recently published a book about his time in the White House and called the President "naive and dangerous"
The President wrote: "I am the ultimate member of The Book of the Month Club. First I have lowlife dummy John Bolton, a war mongering fool, violating the law (he released massive amounts of Classified Information) and an NDA in order to build badly needed credibility and make a few dollars, which will all end up going to the government anyway."
"Many books have been written about me, some good, some bad. Both happily and sadly, there will be more to come!," the President wrote, in conclusion.
Fauci implores state and local leaders to 'be as forceful as possible' with mask orders
Ibadan Killings: 50-yr-old herbalist gives me N500 anytime I kill my victims – 19-year-old confesses
Wilford Brimley, 'Cocoon' actor who appeared in Quaker Oats commercials, dies at 85
A surfer was bit by a shark in Florida's Volusia County, marking its fourth attack this year
Courteney Cox is returning to the big screen for a fifth 'Scream' movie
4 thoughts on "Mary Trump says President 'is not going to get better and he is without question going to get worse'"
Edna Ekiyor
July 18, 2020 at 11:08 pms
This could be true because that man enhh
Ebenu Excellent
July 19, 2020 at 12:00 ams
This one is a family issue
July 19, 2020 at 1:17 pms
Why is Mary trump making this publicly
Let them resolve this case


text:
CityLand Sponsors
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Search results for "Open Space"
Residents Prevent Development in Fight Over Open Space
Court Decisions • Open Space • Upper West Side, Manhattan
Park West Village superblock on the Upper West Side of Manhattan. (808 Columbus Ave, center). Image Credit: Google Maps.
Appellate Division finds that Buildings improperly issued construction permit for nursing home after misinterpreting the zoning resolution. Park West Village is a complex located on a superblock bounded by West 100th Street to the north, West 97th Street to the south, Columbus Avenue to the east, and Amsterdam Avenue to the west on the Upper West Side of Manhattan. The complex was built in the 1950s and 1960s as part of a federally subsidized middle-income urban renewal project, and includes residential buildings, a parking lot, a school, a church, a public library, a health center, and commercial buildings. Three original 16-story residential buildings remain on the eastern portion of the superblock at 784, 788, and 792 Columbus Avenue. The Park West Village buildings all exist on the same zoning lot. (more…)
Tags : Court Decisions, NYC Zoning Resolution, open space ratio (OSR), open space requirements, Park West Village, residential zoning
Comment on Peyton v. NYC BSA
Commentary • Court Decisions • Upper West Side, Manhattan
Part of Park West Village. Image Credit: Google Maps
On December 17, 2020, by a 4-3 decision and over a strong dissent, the Court of Appeals reversed the decision of the Appellate Division in Peyton v. NYC Board of Standards and Appeals, 2020 N.Y. Slip Op. 07662. The decision is an unseemly show of deference to the Board of Standards and Appeals, a body that is widely viewed as captive to the real estate industry, on a pure question of law as to which no deference is owed. The City Council should follow the lead of the U.S. Congress, which, in the Dodd-Frank Act, legislated a less deferential standard of review for certain actions of an agency widely deemed captive to the industry it is supposed to regulate. (more…)
Tags : Board of Standards and Appeals, Court Decisions, guest commentary
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What does Queen Anne/Fremont/Ballard, University/Montlake, Downtown/Pioneer Square, Madison Park/Columbia City, Capitol Hill, Greenwood/Wallingford, Belltown/Pike Place, Bellevue/Kirkland have in common? Savor Seattle Dinner at 8 that is! From September 1-30, on Sunday through Thursday nights, one can have a starter, main dish and dessert for $20 at any of the participating restaurants. Now that's something to look forward to.


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Samsung Galaxy S9+ spotted on Geekbench database
The Samsung Galaxy S9's bigger sibling, the Galaxy S9+ has been spotted on the database of Geekbench, confirming some of the previous rumored specs.
The Galaxy S9+ carries the model number G965U1, and as per the benchmarks will feature Qualcomm's Snapdragon 845 processor, 6GB RAM and ship with Android Oreo.
The device gets a score of 2422 and 8351 in single-core and multi-core test, which is 27 and 31 percent (respectively) higher than Snapdragon 835. This means Snapdragon 845 is going to be a powerful chip for a high-end Android device. However, these scores do not beat iPhone X's Apple A11 Bionic chip. The Galaxy S9+ will also get a variant powered by Samsung's in-house Exynos chip as well.
Previous leaks have suggested that Galaxy S9+ will have 6.2-inch Super AMOLEd Infinity dislay and dual-rear camera. The smaller Galaxy S9 is said to have 5.7-inch display, 4GB RAM and single camera.
According to the latest reports, the Galaxy S9/S9+ will be unveiled at MWC 2018 in February, and hit the stores in March.
Samsung Galaxy S9+ spotted on Geekbench database Reviewed by Kaiser on 12/20/2017 02:50:00 PM


For additional $110.00 you can choose an optional Acrylic cover for 12x12" (30x30cm) and 12x16" (30x41cm) books.
The price includes first 20 pages (10 leaves). You can have up to 160 pages (80 leaves) in your Premium Hard Cover photo book. Additional pages are available in increments of 2 (1 leaf).


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ASEAN and its Future
ASEAN – 50 years on
ASEAN, also known as the Association of Southeast Asian Nations, formed in 1967 as a security arrangement among five states (Indonesia, Malaysia, the Philippines, Singapore, and Thailand), to preserve regional peace, has morphed into an ambitious integration project taking in 10 nations (Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Vietnam).
Back in 1991, the Asean bloc accounted for just 1.7 per cent of the global economy. Today, they have doubled that share to 3.5 per cent, or 6.1 per cent if measured using purchasing power parity. Over the same period, Asean's share of the global population also increased, but by much less, from 8.3 per cent to 8.6 per cent. This process of economic catch-up is steadily bringing Asean's economic weight into line with its demographic weight.
Of course, the region's change and development can be measured in countless other ways. Consider urbanisation. Back in 1991, the region's urban population stood at 143 million (just under a third). Today, Asean has 306 million urban dwellers (nearly half the population). Or, look at technology, Internet penetration has risen from zero to 250 million users, and continues to climb, with another 100 million users expected to connect in the next three years.
The Economies
The Asian narrative is usually bookended by its two largest economies, India and China. Often overlooked is the middle region, the 600 million people of South-east Asia, or Asean.
Because of its relatively fragmented markets, its linguistic, cultural and religious diversity, as well as geographic dispersion across both landlocked and archipelagic nations, many investors have tended to bypass investment opportunities in Asean companies.
What they may not realise is that precisely for these reasons, there is more likely to be an overvaluation of large Indian and Chinese corporates, and underestimation of the oligarchic and opaque governance in these economies.
Economic growth in the Asean 5 – Indonesia, Malaysia, the Philippines, Thailand and Vietnam – will exceed 5 per cent for the next decade, compared with 3 per cent in North Asia. South-east Asia's entire workforce is still growing, while that of North Asia is already contracting.
Asean medium-sized corporates that have become successful regionally have done so with little support from their governments. Asean medium-caps are therefore very competitive, lean and able to manoeuvre deftly in the Asian landscape.
With economic integration across the South-east Asian economies rapidly growing, not due to (rather ineffective) Asean intergovernmental cooperation but because of their own business communities, the potential for Asean corporate growth is more underestimated than in its two larger neighbours.
While the good news is that the economies within ASEAN might see a bonanza of new jobs, the challenge remains that without bold reforms, people will lack the skills to fill these positions.
The World Economic Forum's Human Capital Index reveals how effectively countries are developing and deploying their human capital. Among the indicators used is a survey that asks CEOs to assess the ease of finding skilled employees in their economy. Business leaders in Myanmar, Cambodia, Laos, Thailand and Vietnam all report acute talent shortages, ranking in the bottom half of the 124 countries surveyed. Indonesia, Philippines and Singapore rank 37th, 35th and 20th, respectively. Malaysia, in fourth place, ranks highest on this indicator among the ASEAN countries.
Another challenge is that the very successful model of export-led, labour-intensive and natural resource-dependent growth, which propelled South-east Asian from poverty to wealth in a few decades, will be threatened by what the World Economic Forum calls Revolution 4.0, or what others call the Fourth Industrial Revolution. This disruptive change will be marked by revolutions in genetic engineering, robotics and artificial intelligence, nanotechnology and biotechnology. Computers and the Internet age will be ancient history.
One example of this disruptive change: The International Labour Organisation predicts that robots will replace 85 per cent of the workers in the Vietnamese textile and garment industry over the next two decades. That may seem like a long time, but possibly not nearly long enough for an entire industry and country to transform itself and its economic models.
Asean business leaders are well aware of possibly falling into what has been dubbed "premature deindustrialisation", where economies just on the verge of large-scale industrialisation – Indonesia and Vietnam, for example – are overtaken by post-industrial robotics which are so inexpensive and productive that they can even replace a workforce which is still cheap by developed-world standards, but already expensive and inefficient by robot standards.
To overcome this, Asean economies need to innovate with even newer ways of producing and marketing, as well as creating new "things" for consumers. But it is not happening fast enough.
As for Singapore, it is an economy in transition, somewhat of a hybrid between a quite competitive, productive and sophisticated export platform and a somewhat low-skilled and low-cost domestic economy. Singapore is also a hybrid – being one of the most open and free-market economies in the world, but led by government-dominated corporates and guided by carefully planned and executed road maps for strategic industrial clusters.
Having attained developed economy and high labour cost status many years ago, Singapore's economic future depends on relentless innovation at the corporate level and reinvention at the national level.
Traditional development paths for countries are changing, from export-based manufacturing to providing digital services, with big implications for the future of jobs. Education will have to become digital focused, in order to equip the young with the skills they need in a modern economy.
After several centuries of civilisational decline, Asia is ascendant. It will be a long cycle, punctuated by periodic bursting asset bubbles and economic cycles, but the trend is sustainable and palpable. Long overlooked by its larger and more homogeneous neighbours, South-east Asia is uniquely placed to benefit disproportionately from these trends. But the dangers are equally apparent as disruptive change can unexpectedly stall its rise. South-east Asian thought leaders must rise to both the opportunities as well as the challenges.
Keynote Speech: Ho Kwon Ping, Executive chairman of Banyan Tree Holdings, 2017
New Straits Times, Justin Wood, 2016
TIME, Saadia Zahidi, 2016
Jonathan Khoo, Managing Partner Singapore
Why can't Japanese win Indians and Chinese?
Mid-career talent acquisitions in Japan


text:
Low Vitamin D breaks down muscle by interferring with protein - Editorial Nov 2013
Is Vitamin D a Key Factor in Muscle Health?
Endocrinology November 1, 2013 vol. 154 no. 11 3963-3964
Marie-Laure Kottler
Centre Hospitalier Universitaire de Caen, Department of Genetics, Reference Center for Rare Disorders of Calcium and Phosphorus Metabolism Caen, F-14000, France; UCBN, Caen, F-14032; and Institut National de la Santé et de la Recherché Médicale, U1075, Caen, F-14032, France
Address all correspondence and requests for reprints to: Marie-Laure Kottler M.D., Ph.D., Head Centre Hospitalier Universitaire de Caen Genetics, Avenue Georges Clemenceau, Caen, France F-14033. E-mail: kottler-ml at chu-caen.fr.
Historically, vitamin D is viewed as fundamental to bone mineralization. However, it is well established that muscle strength and muscle mass are important determinants of bone density, bone geometry, and fracture risk. Vitamin D therefore plays a key role in bone metabolism not only through its direct effects on osteoblasts, calcium absorption by the intestines, but also through its effects on muscle fiber size and muscle function (1,–,3).
Vitamin D may influence muscle physical function in 2 ways:
indirectly through calcium-related effects and
directly via its role in muscle cell regulation.
On a cellular level, a variety of mechanisms by which vitamin D impacts upon the function of skeletal muscle have been elucidated. These can be broadly divided into genomic effects that arise from the binding of the nuclear receptor (NR) (vitamin D receptor [VDR]), and nongenomic effects.
In its biologically active form 1,25(OH)2 D binds to VDR, which is a ligand-dependent nuclear transcription factor (4). VDR is heterodimerized with retinoid X receptor (RXR) and the complex activates positive vitamin D response element genes transcription. This increases synthesis of proteins related to several pathways in muscle functions, including Ca2+-binding proteins, such as calmodulin and calbindin D-9K. It also results in an increase in synthesis of other muscle cytoskeletal proteins important for muscle function and trophicity, namely IGF-binding protein-3, thereby inducing muscle hypertrophy. However, in some tissues, RXR levels are greater than VDR levels (5). Therefore, changes in VDR levels are rate limiting for VDR/RXR-mediated target gene expression. Coimmunoprecipitation analyses have also demonstrated direct binding of VDR with c-src under the influence of 1,25(OH)2 D, which mediates the stimulation of muscle growth and differentiation by its subsequent effects on MAPK-signaling pathways (6).
Cellular 1,25(OH)2 D also elicits fast-acting responses that cannot be explained by activation of the slow nuclear VDR genomic pathway that requires hours for protein synthesis. This response is believed to be mediated by the activation of a plasma membrane-associated VDR that stimulates several interacting second-messenger pathways that transmit the signal to the cytoplasm (7). However, a cross talk between 1,25(OH)2 D activation of the plasma-membrane-bound VDR and the nuclear VDR action can exist.
Both types affect Ca2+ handling and muscle cell proliferation and differentiation.
The presence of VDR in muscle has been reported on the basis of immunohistochemistry and detection of VDR mRNA by RT-PCR (7), but these results are subject to challenge due to the experimental conditions (8). Differences in the expression of VDR through the various stages of muscle differentiation may have accounted for these discrepancies.
Deletion of VDR in mice (VDR knockout [KO] mouse model) has provided valuable insights into the biologic function of the vitamin D endocrine system. VDRKO mice present with abnormal skeletal muscle development and deregulated expression of myoregulatory transcription factors (9). These mice display atrophy of type I and II muscle fibers. These changes were observed in VDRKO mice on high-calcium diet, suggesting that the absence of VDR was the predominant cause rather than systemic biochemical changes.
A positive association between vitamin D status and muscle function has been observed in rodent models or in humans.
Vitamin D deficiency impairs excitation-contraction coupling in skeletal muscle leading to impairment in muscle-force generation. In a rat model, a decrease in sarcoplasmic reticulum that impairs the rate of Ca2+ uptake as well as the amount of Ca2+ release in response to an action potential has been described. Expression of myogenic factors was down-regulated, suggesting a decrease in muscle mass.
In humans, muscle weakness in vitamin D-deficient individuals is often described, and biopsies of skeletal muscle in adults show similar type II (fast twitch) muscle fiber atrophy (2).
The precise mechanisms by which vitamin D impairs muscle differentiation, fiber size, and muscle function are unclear.
The paper published in this issue of Endocrinology by Bhat and colleagues (14) is thus an important contribution to this field.
The authors used a vitamin D-deficient rat model supplemented with either calcium or vitamin D to examine whether muscle wasting is due to an increased protein degradation or a decreased protein synthesis or both. They studied the 3 different proteolytic pathways described in the skeletal muscle, namely the ATP-dependent ubiquitin proteasome pathway (UPP), the lysosomal pathway, and the calpaïn pathway.
Substantial observations over the past 5 years support the notion that the ubiquitin–proteasome system plays a role in NR-mediated transcriptional regulation at least through the traditional role in proteolysis of NR and NR cofactor complexes (10). Accordingly, VDR is degraded by the UPP. Elegant studies have shown that vitamin D stabilizes its NR and inhibits degradation by the 26S proteasome (11, 12).
Degradation of cellular proteins via the UPP is a highly complex and tightly regulated process. Proteins targeted for degradation by the 26S proteasome are tagged by ubiquitin moieties with the help of a cascade of 3 enzymes, namely E1, E2, and E3 (10).
In this paper, the authors showed that muscle wasting in vitamin D-deficient rats is due to increased muscle protein breakdown despite food intake similar to vitamin D-sufficient rats. They found an increase of muscle atrophy markers while the expression of the proteasome subunit genes such as the 20S catalytic unit of the 26S proteasome and E2-ubiquitin-conjugating enzyme, was increased. The coordinated up-regulation of enzyme activities, gene and protein expression of various components of the UPP, suggests a major role for vitamin D in this pathway.
These changes were reversed by vitamin D rehabilitation and partially corrected by calcium alone.
The expression of lysosomal enzymes genes and calpaïn enzyme genes was not affected, suggesting that the UPP was the major pathway involved in muscle protein degradation in vitamin D deficiency.
In fasting and presumably in other disease states, muscles play an important role in providing the organism with precursors for hepatic gluconeogenesis or for new protein synthesis. In atrophying rat skeletal muscles, inhibitors of the proteasome reduce the accelerated proteolysis (13).
The data presented in this paper suggest that vitamin D could have a function in preventing proteolysis to mobilize amino acids from dispensable muscle proteins.
Thus, in addition to its role in calcium homeostasis, vitamin D could be an important factor in the balance between protein synthesis and degradation that determines whether muscles hypertrophy or atrophy.
The better understanding of mechanisms of vitamin D action in muscle highlights the significance of maintaining optimal levels of vitamin D and calcium for good muscle health.
1. Boland R . Role of vitamin D in skeletal muscle function. Endocr Rev. 1986;7:434–448. Abstract/FREE Full Text
2. Hazell TJ, DeGuire JR, Weiler HA . Vitamin D: an overview of its role in skeletal muscle physiology in children and adolescents. Nutr Rev. 2012;70:520–533.
3. Girgis CM, Clifton-Bligh RJ, Hamrick MW, Holick MF, Gunton JE . The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev. 2013;34:33–83. Abstract/FREE Full Text
4. Haussler MR, Whitfield GK, Haussler CA, et al . The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res. 1998;13:325–349.
5. Fisher GJ, Talwar HS, Xiao JH, et al . Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. J Biol Chem. 1994;269:20629–20635. Abstract/FREE Full Text
6. Buitrago C, Vazquez G, De Boland AR, Boland RL . Activation of Src kinase in skeletal muscle cells by 1,25-(OH2)-vitamin D3 correlates with tyrosine phosphorylation of the vitamin D receptor (VDR) and VDR-Src interaction. J Cell Biochem. 2000;79:274–281.
7. Buitrago C, Boland R . Caveolae and caveolin-1 are implicated in 1α,25(OH)2-vitamin D3-dependent modulation of Src, MAPK cascades and VDR localization in skeletal muscle cells. J Steroid Biochem Mol Biol. 2010;121:169–175. CrossRefMedline
8. Wang Y, DeLuca HF . Is the vitamin d receptor found in muscle? Endocrinology. 2011;152:354–363. Abstract/FREE Full Text
9. Endo I, Inoue D, Mitsui T, et al . Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology. 2003;144:5138–5144. Abstract/FREE Full Text
10. Glickman MH, Ciechanover A . The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev. 2002;82:373–428. Abstract/FREE Full Text
11. Peleg S, Nguyen CV . The importance of nuclear import in protection of the vitamin D receptor from polyubiquitination and proteasome-mediated degradation. J Cell Biochem. 2010;110:926–934.
12. Li XY, Boudjelal M, Xiao JH, et al . 1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin. Mol Endocrinol. 1999;13:1686–1694. Abstract/FREE Full Text
13. Tawa NE Jr., Odessey R, Goldberg AL . Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles. J Clin Invest. 1997;100:197–203.
14. Bhat, Kalam R, SYH Qadri S, Madabushi S, Ismail A . Vitamin D Deficiency-Induced Muscle Wasting Occurs through the Ubiquitin Proteasome Pathway and Is Partially Corrected by Calcium in Male Rats. Endocrinology. 2013;154:4018–4029.
Muscle in VitaminDWiki title,
Protein aids muscle gain – meta-analysis March 2018
Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT Aug 2014
Vitamin D and bicarbonate perhaps synergistically reduce muscle loss – June 2013
Sarcopenia (muscle loss) and Vitamin D
MRI of elderly skeletal muscle lacking vitamin D – April 2014
Vitamin D provides faster recovery after muscle overuse – April 2013
Muscle cells differentiate into fat cells if there is low vitamin D in petrie dish – April 2013
Elderly lost extra half pound of leg and arm muscle mass if low vitamin D (6 years) – Oct 2014
Overview Sports and vitamin D which has the following summary
Athletes are helped by vitamin D by:
Faster reaction time
Far fewer colds/flus during the winter
Less sore/tired after a workout
Fewer micro-cracks and broken bones
Bones which do break heal much more quickly
Increased VO2 and exercise endurance Feb 2011
Indoor athletes especially need vitamin D
Professional indoor athletes are starting to take vitamin D and/or use UV beds
Olympic athletes have used UV/vitamin D since the 1930's
The biggest gain from the use of vitamin D is by those who exercise less than 2 hours per day.
Reduced muscle fatigue with 10,000 IU vitamin D daily
Muscle strength improved when vitamin D added: 3 Meta-analysis
Reduced Concussions
See also: Sports and Vitamin D category
Loss of muscle strength –sarcopenia – one of the suspects is vitamin D – Aug 2012 which has the following graphic
16142 visitors, last modified 01 Jan, 2019,
Overview Muscles and Vitamin D Sarcopenia (muscle loss) and Vitamin D Low muscle mass at least 2X more likely if low Vitamin D (Korea, all ages) – Dec 2020 Seniors gained 0.3 kg of muscle in 6 weeks with 800 IU and Leucine protein – Aug 2017 Vitamin D provides faster recovery after muscle overuse – April 2013 Vitamin D supplementation improves muscle strength in healthy adults – meta-analysis of 6 RCT Aug 2014 Muscle problems are both treated and avoided by Vitamin D – April 2018 Protein aids muscle gain – meta-analysis March 2018 Overweight senior women with low vitamin D were 12X more likely to be weak – Feb 2018 Elderly lower limb muscle strength improved with Vitamin D supplementation - Meta-analysis Oct 2013 Active vitamin D increased fractional rate of protein synthesis in chickens by 3X – March 2015 Elderly lost extra half pound of leg and arm muscle mass if low vitamin D (6 years) – Oct 2014 Vitamin D and bicarbonate perhaps synergistically reduce muscle loss – June 2013 MRI of elderly skeletal muscle lacking vitamin D – April 2014
Seniors 345 Sports and Vitamin D 246
Overview Muscles and Vitamin DSarcopenia (muscle loss) and Vitamin DLow muscle mass at least 2X more likely if low Vitamin D (Korea, all ages) – ...Seniors gained 0.3 kg of muscle in 6 weeks with 800 IU and Leucine protein – ...Vitamin D provides faster recovery after muscle overuse – April 2013Vitamin D supplementation improves muscle strength in healthy adults – meta-a...Muscle problems are both treated and avoided by Vitamin D – April 2018Protein aids muscle gain – meta-analysis March 2018Overweight senior women with low vitamin D were 12X more likely to be weak – ...Elderly lower limb muscle strength improved with Vitamin D supplementation - ...Active vitamin D increased fractional rate of protein synthesis in chickens b...Elderly lost extra half pound of leg and arm muscle mass if low vitamin D (6 ...Vitamin D and bicarbonate perhaps synergistically reduce muscle loss – June 2013MRI of elderly skeletal muscle lacking vitamin D – April 2014


Alan Gell, a popular auto journalist, was present at the Ride-N-Drive special media at the FC Dallas Toyota soccer stadium, the place where the manufacturer was introducing the all new Sienna, Yaris and Camry. The special guest during the event was Phi Phung, customer sales manager at the Harman Automotive that specializes in sound systems for both Lexus and Toyota vehicles. The company specialized under varied name plates like Harman, Lexicon, Mark Levinson, Revel, Infinity, Kardon, JBL, and AKG. The duo discusses all the latest innovations installed in the Toyota 2015 Camry. It comes with grand new exteriors minus the roof panel.


Each year the color experts at the Pantone Color Institute select a color of the year. For 2017, the choice color is named Greenery, Pantone 15-0343. It is a yellow-green hue which is meant to invoke feelings of rebirth and the coming of spring.
Our juxtaposed mood board features aluminum finishes brought together in unexpected ways. Contrasting aluminum finishes and breaking them up with bright beads.
Over the last year, two finishes or combinations of finishes on aluminum have gotten the most attention from our customers. They are the two most requested samples from our pattern library.


Chemists at the University of Helsinki have created a method of using nanofibers and thin-film biomaterials as orthopedic scaffolds to help regenerate bones and to help implants settle into their new home.
The nanofibers are made of electrospun hydroxyapatite, a naturally occuring mineral form of calcium apatite. The team developed a new, needleless twisted wire, method for creating them.
The materials produced using the new technique can promote new tissue growth and help the healing process along. They are biodegradable and would exit the body after some time, and so won't need to be explanted in a separate procedure.
New processes were developed for various biomaterials and their properties were thoroughly characterized. A method to convert CaCO3 nanostructures to nanocrystalline hydroxyapatite (HA) by treatment in phosphate solution was used to prepare HA thin films and fibers from atomic layer deposited (ALD) and electrospun CaCO3, respectively. HA fibers were also fabricated conventionally by annealing electrospun composite fibers that incorporated Ca and P precursors. Biocomposite fibers of HA nanoparticles and polylactic acid (nHA/PLA) were directly electrospun. These different nanofibers are highly interesting for bone scaffolds owing to their high surface area and the structural similarity to the fibrous nanostructure found in bone. However, conventional electrospinning is limited by its modest production rate. A needleless twisted wire electrospinning (NTWE) setup was developed to increase the production rate and was studied for the preparation of HA fibers for the bone scaffolds. Solution blow spinning (SBS) and electroblowing (EB) of HA were studied as other upscaling alternatives.


text:
See also: endoplasmic reticulum , Erbium
("ER" is also a: user.)
cooled by Jack
(place) by DaVinciLe0 Sun Apr 02 2000 at 8:40:28
acronym for Emergency Room. NBC's treatment specializes in more reality than TV usually gives and many rotating steadycam shots. Of course there's still a bit of soap opera as well, which is understandable seeing all of the beautiful people on the cast. To name a few:
George Clooney, Noah Wyle, Anthony Edwards, Julianna Margulies, Eriq LaSalle, Gloria Reuben, William H. Macy, Laura Innes, Alex Kingston, ... and a bunch more. That's what I could come up with off the top of my head.
(thing) by d_goddard Mon Sep 25 2000 at 4:04:53
A filler word, such as "um" and "uh", but more common in typed communication. Used almost like an emoticon in chat and other informal net communications. Often used to indicate sarcastic content, as in "Windows is, er, not exactly a secure OS".
(idea) by Thomas Miconi Thu Oct 26 2000 at 19:50:32
This one might be called "ER, or how the French discovered that some Americans do have a brain after all."
Okay, so before to downvote me to abyssal levels, sit back and relax, and read on.
First, let me describe the background: we're somewhere around the mid-90s, and French tv programmes are filled with American crap of the 80s. When I say crap, I really mean crap - at that time, Johnny Depp's character in "21 Jump Street" was the most prominent intellectual figure I can think of. Our natural conclusion went along the lines of "dirty yankees ruining our magnificient culture with their stupid, dumbing shit, what else would you expect from cultureless cow boys" (but here this is the most frequent conclusion of about any debate in which the US are involved).
Needless to say, those "crappy tv series" that everybody hated so much reached Himalayan audience levels among our oh-so-brilliant-and-cultivated fellow citizens (how do you think I know that Johnny Depp played in 21 Jump Street ?).
Of course, some of us already knew that American tv programmes might be very good indeed (because they had been able to see Seinfeld, Twin Peaks, etc. on cable tv, which was quite rare at the time), and that only the greed and risk-averseness of our own TV networks had led to that situation. But all in all, the result was the same : to 95% of the French population, "american tv series" was synonymous to "commercial piece of shit", and was used as such in everyday conversation.
And then there was ER. Ouch ! For the first time, the majority of us were able to see an american tv show where real characters, with real stories, real personalities and real feelings, led real lives in an (almost) realistic environment. The complex psychological descriptions were especially surprising for us - many of us were sincerely convinced than only in a french film could such a thing be found, and Hollywood had done little to change our minds on that subject.
All in all, the broadcasting of ER on a (state-owned !) french television channel has done more against stereotypes anc cliches on this side of the atlantic ocean than any other documentary/fiction/whatever tv programme. This contribution to transatlantic mutual understanding may be an unexpected effect, but will certainly not be the least important one.
(thing) by wonko Sat Apr 20 2002 at 22:24:00
ER began as a collaboration between Steven Spielberg and Michael Crichton. Their initial goal was to come up with a movie based on the doctors and events in a hospital emergency room, to be directed by Spielberg. However, things didn't quite go as planned and the project was dropped. Spielberg directed a movie adaptation of Michael Crichton's Jurassic Park instead.
Crichton kept at it, though, and his plan for a movie evolved into a plan for a television series, which he came to believe would be a much more fitting way of telling an ongoing, continuous story. Warner Brothers produced the show and NBC picked it up in 1994. The show instantly shot up to number one in the ratings.
Eight years later, ER is still one of the most popular shows on television, consistently ranking first in its timeslot. It also holds the distinction of being one of the most realistic, well-written, well-acted and (perhaps not coincidentally) expensive shows on TV. The cast has gone through many changes since the first episode, but even though only two original cast members remain (with one leaving the show this season) ER is every bit as good as (if not better than) the day it first aired.
It's also no coincidence that the show has boosted the careers of many, many people. George Clooney went from a relative unknown to an international superstar almost overnight, as did (to a lesser extent) Noah Wyle, Ming-Na Wen, and Julianna Margulies. In addition to actors, ER has spawned several other big names. Director Mimi Leder got her start directing episodes of China Beach and, later, ER. Quentin Tarantino even directed an episode, although his career was already well-established.
All in all, this show has some of the highest production values on television, and is probably responsible for the recent bombardment of high quality TV -- something that I don't think anyone's complaining about.
(thing) by teleny Mon Jan 09 2006 at 23:03:47
It might help some American folks that "er" alone in British English isn't to be pronounced like the last syllable of "maker" but like the last mumble of "butter", rather like the American "uh", but utterly different than "Ah."
Noah Wyle Ming-Na Wen Emergency Room George Clooney
Laura Innes Six Feet Under Dawn was a lucky time to give birth Julianna Margulies
Dawson's Creek The West Wing Code Blue William H. Macy
Scrubs Shooting yourself in the head for fun and profit Lactated Ringer's Injection Anthony Edwards
endoplasmic reticulum How to treat brain injuries CBC TM
Tom Irwin Mimi Leder Long Island College Hospital Ralph Fiennes
The Dying Words of Stonewall Jackson
How to give a hug
Why the Borg have such terrible fashion sense


text:
CEBP Focus Archive
Disparities Collection
Which Risk Model to Use? Clinical Implications of the ACS MRI Screening Guidelines
Elissa M. Ozanne, Brian Drohan, Phil Bosinoff, Alan Semine, Michael Jellinek, Claire Cronin, Frederick Millham, Dana Dowd, Taryn Rourke, Caroline Block and Kevin S. Hughes
Elissa M. Ozanne
Authors' Affiliations: University of California, San Francisco, California; Division of Surgical Oncology, Massachusetts General Hospital; Harvard Medical School; Tufts University School of Medicine, Boston; and Newton-Wellesley Hospital, Newton, Massachusetts
Brian Drohan
Phil Bosinoff
Alan Semine
Authors' Affiliations: University of California, San Francisco, California; Division of Surgical Oncology, Massachusetts General Hospital; Harvard Medical School; Tufts University School of Medicine, Boston; and Newton-Wellesley Hospital, Newton, MassachusettsAuthors' Affiliations: University of California, San Francisco, California; Division of Surgical Oncology, Massachusetts General Hospital; Harvard Medical School; Tufts University School of Medicine, Boston; and Newton-Wellesley Hospital, Newton, Massachusetts
Michael Jellinek
Claire Cronin
Frederick Millham
Dana Dowd
Taryn Rourke
Caroline Block
Kevin S. Hughes
Authors' Affiliations: University of California, San Francisco, California; Division of Surgical Oncology, Massachusetts General Hospital; Harvard Medical School; Tufts University School of Medicine, Boston; and Newton-Wellesley Hospital, Newton, MassachusettsAuthors' Affiliations: University of California, San Francisco, California; Division of Surgical Oncology, Massachusetts General Hospital; Harvard Medical School; Tufts University School of Medicine, Boston; and Newton-Wellesley Hospital, Newton, MassachusettsAuthors' Affiliations: University of California, San Francisco, California; Division of Surgical Oncology, Massachusetts General Hospital; Harvard Medical School; Tufts University School of Medicine, Boston; and Newton-Wellesley Hospital, Newton, Massachusetts
DOI: 10.1158/1055-9965.EPI-12-0570 Published January 2013
Correction: Which Risk Model to Use? Clinical Implications of the ACS MRI Screening Guidelines - June 9, 2013
The American Cancer Society (ACS) guidelines define the appropriate use of MRI as an adjunct to mammography for breast cancer screening. Three risk assessment models are recommended to determine if women are at sufficient risk to warrant the use of this expensive screening tool, however, the real-world application of these models has not been explored. We sought to understand how these models behave in a community setting for women undergoing mammography screening. We conducted a retrospective analysis of 5,894 women, who received mammography screening at a community hospital and assessed their eligibility for MRI according to the ACS guidelines. Of the 5,894 women, 342 (5.8%) were eligible for MRI, but we found significant differences in the number of eligible women identified by each model. Our results indicate that these models identify very different populations, implying that the ACS guidelines deserve further development and consideration. Cancer Epidemiol Biomarkers Prev; 22(1); 146–9. ©2012 AACR.
Revision received September 14, 2012.
Accepted October 12, 2012.
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Date: 18th July 2017 at 8:17am
Written by: VitalRovers
No, I'm not going all musical, which I'm sure 'getting to know you' is, I'm merely referring to Peter Whittingham and his comments regarding getting to know his new teammates better during Blackburn's recent tour.
Whittingham, who became the first signing of the Tony Mowbray era, has reflected on Rovers' week in Austria and the hard work put in on the training pitch will pay off along with the benefits of getting to know his new colleagues too.
An important period ahead of the upcoming season, Whittingham told the Official Website this, along with 'a lot of running', can be central to the campaign ahead.
'It's really good to meet the boys, spend time with them, and getting to know people who you are hopefully going to be spending time playing with this season. It's massive to be with everyone and getting to know people. That, and a lot of running. It's been a tough week, I don't think anyone will be denying that, it's been really hard in aspects, and the game was bit of a relief.'
Adding: 'For me as a newcomer getting to integrate with the whole of the squad was great. It's been tough the running, it doesn't get easier as you get older, but it needs to be done and we're ready for the season now.'
With the formalities of getting to know your new teammates, along with their good (and bad) habits, after working on the fitness the next stage will be tactical and adapting during a game situation as Rovers move closer to the League One campaign.
He said: 'Early doors it's about fitness, getting the lungs back and see how you're getting on. As the pre-season progresses it's about how you are going to adapt to certain situations and results.'


text:
Privacy Policy and Terms of Useclocktower2019-12-20T03:44:48+00:00
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2018 is the Year of the Beet!
This heavy duty 100% cotton Gardener's apron, made for chefs, is ideal for gardeners. Images are fun and whimsical and washable. Deep pockets allow easy carrying of small tools, gloves or your cell phone into the garden. This is one of Donna's favourite garden accessories. One size fits all with adjustable neck. Only available here on this website!